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Sample records for program ibm pc

  1. Mathematics Programming on the Apple II and IBM PC.

    Science.gov (United States)

    Myers, Roy E.; Schneider, David I.

    1987-01-01

    Details the features of BASIC used in mathematics programming and provides the information needed to translate between the Apple II and IBM PC computers. Discusses inputing a user-defined function, setting scroll windows, displaying subscripts and exponents, variable names, mathematical characters and special symbols. (TW)

  2. Hands-on program of IBM-PC training at Los Alamos National Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Lier, R.H.

    1985-01-01

    Since December 1983, the Laboratory has offered introductory courses of IBM-PC training. A comprehensive needs assessment was conducted and a nine-course module of classes was designed and implemented. Forty classes were completed in the one-year period. The target group includes the novice computer user in the scientific, management, administrative, and secretarial personnel groups. The development, needs assessment, course implementation and design, course evaluations, and future direction of computer training will be discussed. Lab-automation, robotics, design of the lab and office and the impact of computer on society will be discussed briefly.

  3. ICAN - INTEGRATED COMPOSITE ANALYZER (IBM PC VERSION)

    Science.gov (United States)

    Murthy, P. L.

    1994-01-01

    , macromechanics, and laminate analysis including the hygrothermal response of fiber composites. ICAN output includes the various ply and composite properties, composite structural response, and composite stress analysis results with details of failure. Output can be tailored to specific needs by choosing the appropriate options. Two machine versions of ICAN are available. The IBM 370 series version (LEW-14468) is written in FORTRAN IV for the IBM 370 series computers running OS/TSS. The IBM PC version (LEW-15592) is written in FORTRAN 77 for use on the IBM PC series computers running MS-DOS and Microsoft FORTRAN 5.1. The IBM 370 version requires 3.5Mb of memory for execution. No sample executable is provided. For the IBM PC version, a sample executable, along with sample input and output data, is included on the distribution medium. Although the included executable requires a math coprocessor, the ICAN source can be recompiled into an executable which does not require a math coprocessor. The standard distribution medium for the IBM 370 version of ICAN is a 9-track 1600 BPI magnetic tape in EBCDIC CARD IMAGE format. The standard distribution medium for the IBM PC version is one 5.25 inch 360K MS-DOS format diskette. The contents of the diskette are compressed using the PKWARE archiving tools. The utility to unarchive the files, PKUNZIP.EXE, is included. ICAN was developed in 1986 and the IBM PC version was released in 1992.

  4. Accounting, from rock to standards IBM PC

    OpenAIRE

    Hora, Michal

    2016-01-01

    This paper focuses on the historical evolution of computing tools from ancient antiquity to the personal computer, the IBM PC standard. It describes the first computing devices, the first mechanical calculating machines to store data. It has also captured the dramatic development of calculating machines in the second half of the twentieth century.

  5. IBM PC/IX operating system evaluation plan

    Science.gov (United States)

    Dominick, Wayne D. (Editor); Granier, Martin; Hall, Philip P.; Triantafyllopoulos, Spiros

    1984-01-01

    An evaluation plan for the IBM PC/IX Operating System designed for IBM PC/XT computers is discussed. The evaluation plan covers the areas of performance measurement and evaluation, software facilities available, man-machine interface considerations, networking, and the suitability of PC/IX as a development environment within the University of Southwestern Louisiana NASA PC Research and Development project. In order to compare and evaluate the PC/IX system, comparisons with other available UNIX-based systems are also included.

  6. CLIPS - C LANGUAGE INTEGRATED PRODUCTION SYSTEM (IBM PC VERSION)

    Science.gov (United States)

    Riley, G.

    1994-01-01

    The C Language Integrated Production System, CLIPS, is a shell for developing expert systems. It is designed to allow artificial intelligence research, development, and delivery on conventional computers. The primary design goals for CLIPS are portability, efficiency, and functionality. For these reasons, the program is written in C. CLIPS meets or outperforms most micro- and minicomputer based artificial intelligence tools. CLIPS is a forward chaining rule-based language. The program contains an inference engine and a language syntax that provide a framework for the construction of an expert system. It also includes tools for debugging an application. CLIPS is based on the Rete algorithm, which enables very efficient pattern matching. The collection of conditions and actions to be taken if the conditions are met is constructed into a rule network. As facts are asserted either prior to or during a session, CLIPS pattern-matches the number of fields. Wildcards and variables are supported for both single and multiple fields. CLIPS syntax allows the inclusion of externally defined functions (outside functions which are written in a language other than CLIPS). CLIPS itself can be embedded in a program such that the expert system is available as a simple subroutine call. Advanced features found in CLIPS version 4.3 include an integrated microEMACS editor, the ability to generate C source code from a CLIPS rule base to produce a dedicated executable, binary load and save capabilities for CLIPS rule bases, and the utility program CRSV (Cross-Reference, Style, and Verification) designed to facilitate the development and maintenance of large rule bases. Five machine versions are available. Each machine version includes the source and the executable for that machine. The UNIX version includes the source and binaries for IBM RS/6000, Sun3 series, and Sun4 series computers. The UNIX, DEC VAX, and DEC RISC Workstation versions are line oriented. The PC version and the Macintosh

  7. SPP: Student Problem Package on the IBM-PC. User's Guide, Version 1.0.

    Science.gov (United States)

    Harnisch, Delwyn L.; Romy, Neil

    This is a user's guide to the Student-Problem Package (SPP), a software package for the IBM-PC that provides three sub-programs for analyzing item response patterns. These analyses are based on student-problem (S-P) curve theory. The SPP User's Guide provides: (1) a brief introduction to response pattern analysis; (2) an overview of the…

  8. User's manual for levelized power generation cost using an IBM PC

    Energy Technology Data Exchange (ETDEWEB)

    Fuller, L.C.

    1985-06-01

    Programs for the estimation of levelized electric power generation costs using the BASIC interpreter on an IBM PC are described. Procedures for light-water reactor plants and coal-fired plants include capital investment cost, operation and maintenance cost, fuel cycle cost, nuclear decommissioning cost, and levelized total generation cost.

  9. CLIPS - C LANGUAGE INTEGRATED PRODUCTION SYSTEM (IBM PC VERSION WITH CLIPSITS)

    Science.gov (United States)

    Riley, , .

    1994-01-01

    The C Language Integrated Production System, CLIPS, is a shell for developing expert systems. It is designed to allow artificial intelligence research, development, and delivery on conventional computers. The primary design goals for CLIPS are portability, efficiency, and functionality. For these reasons, the program is written in C. CLIPS meets or outperforms most micro- and minicomputer based artificial intelligence tools. CLIPS is a forward chaining rule-based language. The program contains an inference engine and a language syntax that provide a framework for the construction of an expert system. It also includes tools for debugging an application. CLIPS is based on the Rete algorithm, which enables very efficient pattern matching. The collection of conditions and actions to be taken if the conditions are met is constructed into a rule network. As facts are asserted either prior to or during a session, CLIPS pattern-matches the number of fields. Wildcards and variables are supported for both single and multiple fields. CLIPS syntax allows the inclusion of externally defined functions (outside functions which are written in a language other than CLIPS). CLIPS itself can be embedded in a program such that the expert system is available as a simple subroutine call. Advanced features found in CLIPS version 4.3 include an integrated microEMACS editor, the ability to generate C source code from a CLIPS rule base to produce a dedicated executable, binary load and save capabilities for CLIPS rule bases, and the utility program CRSV (Cross-Reference, Style, and Verification) designed to facilitate the development and maintenance of large rule bases. Five machine versions are available. Each machine version includes the source and the executable for that machine. The UNIX version includes the source and binaries for IBM RS/6000, Sun3 series, and Sun4 series computers. The UNIX, DEC VAX, and DEC RISC Workstation versions are line oriented. The PC version and the Macintosh

  10. An IBM 370 assembly language program verifier

    Science.gov (United States)

    Maurer, W. D.

    1977-01-01

    The paper describes a program written in SNOBOL which verifies the correctness of programs written in assembly language for the IBM 360 and 370 series of computers. The motivation for using assembly language as a source language for a program verifier was the realization that many errors in programs are caused by misunderstanding or ignorance of the characteristics of specific computers. The proof of correctness of a program written in assembly language must take these characteristics into account. The program has been compiled and is currently running at the Center for Academic and Administrative Computing of The George Washington University.

  11. AMPS/PC - AUTOMATIC MANUFACTURING PROGRAMMING SYSTEM

    Science.gov (United States)

    Schroer, B. J.

    1994-01-01

    The AMPS/PC system is a simulation tool designed to aid the user in defining the specifications of a manufacturing environment and then automatically writing code for the target simulation language, GPSS/PC. The domain of problems that AMPS/PC can simulate are manufacturing assembly lines with subassembly lines and manufacturing cells. The user defines the problem domain by responding to the questions from the interface program. Based on the responses, the interface program creates an internal problem specification file. This file includes the manufacturing process network flow and the attributes for all stations, cells, and stock points. AMPS then uses the problem specification file as input for the automatic code generator program to produce a simulation program in the target language GPSS. The output of the generator program is the source code of the corresponding GPSS/PC simulation program. The system runs entirely on an IBM PC running PC DOS Version 2.0 or higher and is written in Turbo Pascal Version 4 requiring 640K memory and one 360K disk drive. To execute the GPSS program, the PC must have resident the GPSS/PC System Version 2.0 from Minuteman Software. The AMPS/PC program was developed in 1988.

  12. A user-friendly, menu-driven, language-free laser characteristics curves graphing program for desk-top IBM PC compatible computers

    Science.gov (United States)

    Klutz, Glenn

    1989-01-01

    A facility was established that uses collected data and feeds it into mathematical models that generate improved data arrays by correcting for various losses, base line drift, and conversion to unity scaling. These developed data arrays have headers and other identifying information affixed and are subsequently stored in a Laser Materials and Characteristics data base which is accessible to various users. The two part data base: absorption - emission spectra and tabulated data, is developed around twelve laser models. The tabulated section of the data base is divided into several parts: crystalline, optical, mechanical, and thermal properties; aborption and emission spectra information; chemical name and formulas; and miscellaneous. A menu-driven, language-free graphing program will reduce and/or remove the requirement that users become competent FORTRAN programmers and the concomitant requirement that they also spend several days to a few weeks becoming conversant with the GEOGRAF library and sequence of calls and the continual refreshers of both. The work included becoming thoroughly conversant with or at least very familiar with GEOGRAF by GEOCOMP Corp. The development of the graphing program involved trial runs of the various callable library routines on dummy data in order to become familiar with actual implementation and sequencing. This was followed by trial runs with actual data base files and some additional data from current research that was not in the data base but currently needed graphs. After successful runs, with dummy and real data, using actual FORTRAN instructions steps were undertaken to develop the menu-driven language-free implementation of a program which would require the user only know how to use microcomputers. The user would simply be responding to items displayed on the video screen. To assist the user in arriving at the optimum values needed for a specific graph, a paper, and pencil check list was made available to use on the trial runs.

  13. CLIPS 6.0 - C LANGUAGE INTEGRATED PRODUCTION SYSTEM, VERSION 6.0 (IBM PC VERSION)

    Science.gov (United States)

    Donnell, B.

    1994-01-01

    COOL (that is, a rule can pattern match on objects created using COOL). CLIPS 6.0 provides the capability to define functions, overloaded functions, and global variables interactively. In addition, CLIPS can be embedded within procedural code, called as a subroutine, and integrated with languages such as C, FORTRAN and Ada. CLIPS can be easily extended by a user through the use of several well-defined protocols. CLIPS provides several delivery options for programs including the ability to generate stand alone executables or to load programs from text or binary files. CLIPS 6.0 provides support for the modular development and execution of knowledge bases with the defmodule construct. CLIPS modules allow a set of constructs to be grouped together such that explicit control can be maintained over restricting the access of the constructs by other modules. This type of control is similar to global and local scoping used in languages such as C or Ada. By restricting access to deftemplate and defclass constructs, modules can function as blackboards, permitting only certain facts and instances to be seen by other modules. Modules are also used by rules to provide execution control. The CRSV (Cross-Reference, Style, and Verification) utility included with previous version of CLIPS is no longer supported. The capabilities provided by this tool are now available directly within CLIPS 6.0 to aid in the development, debugging, and verification of large rule bases. COSMIC offers four distribution versions of CLIPS 6.0: UNIX (MSC-22433), VMS (MSC-22434), MACINTOSH (MSC-22429), and IBM PC (MSC-22430). Executable files, source code, utilities, documentation, and examples are included on the program media. All distribution versions include identical source code for the command line version of CLIPS 6.0. This source code should compile on any platform with an ANSI C compiler. Each distribution version of CLIPS 6.0, except that for the Macintosh platform, includes an executable for the

  14. Research on the IBM Grant Program's Impact on Teacher Preparation.

    Science.gov (United States)

    Bitter, Gary G.; Pryor, Brandt W.

    Technology is not often a factor in classroom activities because teachers are untrained in its use. In 1990, International Business Machines (IBM) contributed over 30 million dollars' worth of workstations, networking hardware and software, IBM courseware, cash, and training to prompt 144 selected teacher preparation programs to integrate…

  15. JKPLOT version 2.00: A device-independent plotting system written in QuickBasic for an IBM PC

    Science.gov (United States)

    Kork, J.O.

    1994-01-01

    Version 2.0 of JKPLOT is a simple, device-independent plotting system that can provide a base for building plotting facilities tailored to the needs of geologists. The programs were written in Microsoft QuickBasic for use on equipment compatible with an IBM personal computer. The system provides subroutines and functions for plotting in both 2 and 3 dimensions with the capability for making scaled plots with annotated axes. Plot output can be directed to the PC screen, an Epson printer, any HPGL pen plotter, or an HP laser printer. The user's documentation and program diskettes of the JKPLOT system are available from U.S. Geological Survey Open File Services. ?? 1994.

  16. International Border Management Systems (IBMS) Program : visions and strategies.

    Energy Technology Data Exchange (ETDEWEB)

    McDaniel, Michael; Mohagheghi, Amir Hossein

    2011-02-01

    Sandia National Laboratories (SNL), International Border Management Systems (IBMS) Program is working to establish a long-term border security strategy with United States Central Command (CENTCOM). Efforts are being made to synthesize border security capabilities and technologies maintained at the Laboratories, and coordinate with subject matter expertise from both the New Mexico and California offices. The vision for SNL is to provide science and technology support for international projects and engagements on border security.

  17. Optimizing The Performance of Streaming Numerical Kernels On The IBM Blue Gene/P PowerPC 450

    KAUST Repository

    Malas, Tareq

    2011-07-01

    Several emerging petascale architectures use energy-efficient processors with vectorized computational units and in-order thread processing. On these architectures the sustained performance of streaming numerical kernels, ubiquitous in the solution of partial differential equations, represents a formidable challenge despite the regularity of memory access. Sophisticated optimization techniques beyond the capabilities of modern compilers are required to fully utilize the Central Processing Unit (CPU). The aim of the work presented here is to improve the performance of streaming numerical kernels on high performance architectures by developing efficient algorithms to utilize the vectorized floating point units. The importance of the development time demands the creation of tools to enable simple yet direct development in assembly to utilize the power-efficient cores featuring in-order execution and multiple-issue units. We implement several stencil kernels for a variety of cached memory scenarios using our Python instruction simulation and generation tool. Our technique simplifies the development of efficient assembly code for the IBM Blue Gene/P supercomputer\\'s PowerPC 450. This enables us to perform high-level design, construction, verification, and simulation on a subset of the CPU\\'s instruction set. Our framework has the capability to implement streaming numerical kernels on current and future high performance architectures. Finally, we present several automatically generated implementations, including a 27-point stencil achieving a 1.7x speedup over the best previously published results.

  18. Implementation of a General Finite Element Code on an IBM PC Compatible Microcomputer.

    Science.gov (United States)

    1984-09-01

    l-r,0 ?CC.’j\\ WR1TE(#,’( APA )k’ PRICESSIN:G 9BLCY’ v, BLO-C 1,17 APPENDIX E MEF PROGRAM LISTINGS 4 The orogram listings for MEF are provided belowe...2,-30) (Vi :), ,!=-i, D- 2030 FORMATO )’ fl).iX,7E12.5) 40) CONTINUE C---- READ NODE CARDS 50 READ (MI, 1020) (’AV() 14=!,L16) 164 1020 tX FORM NEQ 00

  19. IBM 5150 computer

    CERN Multimedia

    1981-01-01

    IBM’s first personal computer arrived nearly 10 years after others companies, but instantly legitimized the market. IBM introduced its PC in 1981. IBM equipped the model 5150 with a cassette port for connecting a cassette drive. The first IBM PC ran on a 4.77 MHz Intel 8088 microprocessor. The PC came equipped with 16 kilobytes of memory, expandable to 256k. The PC came with one or two 160k floppy disk drives and an optional color monitor. The price tag started at $1,565, which would be nearly $4,000 (about €3,400) today.

  20. Linear circuit analysis program for IBM 1620 Monitor 2, 1311/1443 data processing system /CIRCS/

    Science.gov (United States)

    Hatfield, J.

    1967-01-01

    CIRCS is modification of IBSNAP Circuit Analysis Program, for use on smaller systems. This data processing system retains the basic dc, transient analysis, and FORTRAN 2 formats. It can be used on the IBM 1620/1311 Monitor I Mod 5 system, and solves a linear network containing 15 nodes and 45 branches.

  1. A performance evaluation of the IBM 370/XT personal computer

    Science.gov (United States)

    Dominick, Wayne D. (Editor); Triantafyllopoulos, Spiros

    1984-01-01

    An evaluation of the IBM 370/XT personal computer is given. This evaluation focuses primarily on the use of the 370/XT for scientific and technical applications and applications development. A measurement of the capabilities of the 370/XT was performed by means of test programs which are presented. Also included is a review of facilities provided by the operating system (VM/PC), along with comments on the IBM 370/XT hardware configuration.

  2. Flexible input, dazzling output with IBM i

    CERN Document Server

    Victória-Pereira, Rafael

    2014-01-01

    Link your IBM i system to the modern business server world! This book presents easier and more flexible ways to get data into your IBM i system, along with rather surprising methods to export and present the vital business data it contains. You'll learn how to automate file transfers, seamlessly connect PC applications with your RPG programs, and much more. Input operations will become more flexible and user-proof, with self-correcting import processes and direct file transfers that require a minimum of user intervention. Also learn novel ways to present information: your DB2 data will look gr

  3. Programming portlets from JSR 168 to IBM WebSphere portal extensions

    CERN Document Server

    Bernal, Joey; Lynn, Ron; Marston, Cayce; Memon, Usman

    2012-01-01

    Portals have evolved from simple Web applications with multiple links to an enterprise application delivery platform that serves composite applications. In a world where organizations are gearing up with service-oriented architecture (SOA) strategies and re-working existing apps to fit the Web 2.0 programming model, portals are strategic infrastructure components on every CIO's radar. As companies move toward SOA, portlets become an even hotter topic. Portlets provide the user interface for these services. IBM's unwavering commitment to open standards such as Java Specification Request (JSR 16

  4. WINDOW 4. 0: Program description. A PC program for analyzing the thermal performance of fenestration products

    Energy Technology Data Exchange (ETDEWEB)

    1992-03-01

    WINDOW 4.0 is a publicly available IBM PC compatible computer program developed by the Windows and Daylighting Group at Lawrence Berkeley Laboratory for calculating total window thermal performance indices (e.g. U-values, solar heat gain coefficients, shading coefficients, and visible transmittances). WINDOW 4.0 provides a versatile heat transfer analysis method consistent with the rating procedure developed by the National Fenestration Rating Council (NFRC). The program can be used to design and develop new products, to rate and compare performance characteristics of all types of window products, to assist educators in teaching heat transfer through windows, and to help public officials in developing building energy codes. WINDOW 4.0 is a major revision to WINDOW 3.1 and we strongly urge all users to read this manual before using the program. Users who need professional assistance with the WINDOW 4.0 program or other window performance simulation issues are encouraged to contact one or more of the NFRC-accredited Simulation Laboratories. A list of these accredited simulation professionals is available from the NFRC.

  5. IBM eile, täna ja homme / Kalle Kose

    Index Scriptorium Estoniae

    Kose, Kalle

    2007-01-01

    Infotehnoloogiafirma IBM arengust. Lisatud joonised: PC tootjate turuosad (1984-2004); IBM-i käive segmentide lõikes (2000-2005); IBM-i käive kvartaalselt. Vt. ka lk.13: IBM püstitas patentide rekordi

  6. National Support Center: A Service of IBM.

    Science.gov (United States)

    Exceptional Parent, 1990

    1990-01-01

    This article describes (1) IBM's National Support Center for Persons with Disabilities, a clearinghouse of information about adaptive devices, software, and support groups helping disabled persons use IBM computers; (2) special IBM products, including the Screen Reader, SpeechViewer, and PhoneCommunicator; and (3) an IBM-sponsored program whereby…

  7. ICAN - INTEGRATED COMPOSITE ANALYZER (IBM 370 VERSION)

    Science.gov (United States)

    Murthy, P. L.

    1994-01-01

    , macromechanics, and laminate analysis including the hygrothermal response of fiber composites. ICAN output includes the various ply and composite properties, composite structural response, and composite stress analysis results with details of failure. Output can be tailored to specific needs by choosing the appropriate options. Two machine versions of ICAN are available. The IBM 370 series version (LEW-14468) is written in FORTRAN IV for the IBM 370 series computers running OS/TSS. The IBM PC version (LEW-15592) is written in FORTRAN 77 for use on the IBM PC series computers running MS-DOS and Microsoft FORTRAN 5.1. The IBM 370 version requires 3.5Mb of memory for execution. No sample executable is provided. For the IBM PC version, a sample executable, along with sample input and output data, is included on the distribution medium. Although the included executable requires a math coprocessor, the ICAN source can be recompiled into an executable which does not require a math coprocessor. The standard distribution medium for the IBM 370 version of ICAN is a 9-track 1600 BPI magnetic tape in EBCDIC CARD IMAGE format. The standard distribution medium for the IBM PC version is one 5.25 inch 360K MS-DOS format diskette. The contents of the diskette are compressed using the PKWARE archiving tools. The utility to unarchive the files, PKUNZIP.EXE, is included. ICAN was developed in 1986 and the IBM PC version was released in 1992.

  8. Cost-benefit study of consumer product take-back programs using IBM's WIT reverse logistics optimization tool

    Science.gov (United States)

    Veerakamolmal, Pitipong; Lee, Yung-Joon; Fasano, J. P.; Hale, Rhea; Jacques, Mary

    2002-02-01

    In recent years, there has been increased focus by regulators, manufacturers, and consumers on the issue of product end of life management for electronics. This paper presents an overview of a conceptual study designed to examine the costs and benefits of several different Product Take Back (PTB) scenarios for used electronics equipment. The study utilized a reverse logistics supply chain model to examine the effects of several different factors in PTB programs. The model was done using the IBM supply chain optimization tool known as WIT (Watson Implosion Technology). Using the WIT tool, we were able to determine a theoretical optimal cost scenario for PTB programs. The study was designed to assist IBM internally in determining theoretical optimal Product Take Back program models and determining potential incentives for increasing participation rates.

  9. WINDOW 4.0: Program description. A PC program for analyzing the thermal performance of fenestration products

    Energy Technology Data Exchange (ETDEWEB)

    1992-03-01

    WINDOW 4.0 is a publicly available IBM PC compatible computer program developed by the Windows and Daylighting Group at Lawrence Berkeley Laboratory for calculating total window thermal performance indices (e.g. U-values, solar heat gain coefficients, shading coefficients, and visible transmittances). WINDOW 4.0 provides a versatile heat transfer analysis method consistent with the rating procedure developed by the National Fenestration Rating Council (NFRC). The program can be used to design and develop new products, to rate and compare performance characteristics of all types of window products, to assist educators in teaching heat transfer through windows, and to help public officials in developing building energy codes. WINDOW 4.0 is a major revision to WINDOW 3.1 and we strongly urge all users to read this manual before using the program. Users who need professional assistance with the WINDOW 4.0 program or other window performance simulation issues are encouraged to contact one or more of the NFRC-accredited Simulation Laboratories. A list of these accredited simulation professionals is available from the NFRC.

  10. NASIS data base management system - IBM 360/370 OS MVT implementation. 4: Program design specifications

    Science.gov (United States)

    1973-01-01

    The design specifications for the programs and modules within the NASA Aerospace Safety Information System (NASIS) are presented. The purpose of the design specifications is to standardize the preparation of the specifications and to guide the program design. Each major functional module within the system is a separate entity for documentation purposes. The design specifications contain a description of, and specifications for, all detail processing which occurs in the module. Sub-modules, reference tables, and data sets which are common to several modules are documented separately.

  11. CONTOUR. BLACKBOX: a contour mapping program. [In FORTRAN for IBM computers

    Energy Technology Data Exchange (ETDEWEB)

    Malon, D.M.

    1975-10-01

    CONTOUR.BLACKBOX is an AMD-implemented revision of a non-Argonne contouring program. It handles up to 7500 data points, and, with several control cards specifying input--output parameters, produces an appropriately formatted contour map. 6 figures.

  12. IBM 3705 Communications Controller

    CERN Multimedia

    1972-01-01

    The IBM 3705 Communications Controller is a simple computer which attaches to an IBM System/360 or System/370. Its purpose is to connect communication lines to the mainframe channel. It was a first communications controller of the popular IBM 37xx series.

  13. Menu-Driven Solver Of Linear-Programming Problems

    Science.gov (United States)

    Viterna, L. A.; Ferencz, D.

    1992-01-01

    Program assists inexperienced user in formulating linear-programming problems. A Linear Program Solver (ALPS) computer program is full-featured LP analysis program. Solves plain linear-programming problems as well as more-complicated mixed-integer and pure-integer programs. Also contains efficient technique for solution of purely binary linear-programming problems. Written entirely in IBM's APL2/PC software, Version 1.01. Packed program contains licensed material, property of IBM (copyright 1988, all rights reserved).

  14. IBM 3380 E

    CERN Multimedia

    1985-01-01

    In 1985 IBM announced a double density version. The Extended Capability Models of the 3380 (3380 E) having 5.04 gigabytes per chassis, that is, two 1.26 gigabyte actuators on two hard disk assemblies in one chassis.

  15. IBM model M keyboard

    CERN Multimedia

    1985-01-01

    In 1985, the IBM Model M keyboard was created. This timeless classic was a hit. IBM came out with several varients of the model M. They had the space saver 104 key which is the one most seen today and many international versions of that as well. The second type, and rarest is the 122 key model M which has 24 extra keys at the very top, dubbed the “programmers keyboard”. IBM manufactured these keyboards until 1991. The model M features “caps” over the actual keys that can be taken off separately one at a time for cleaning or to replace them with colored keys or keys of another language, that was a very cost effective way of shipping out internationally the keyboards.

  16. Implementation of NASTRAN on the IBM/370 CMS operating system

    Science.gov (United States)

    Britten, S. S.; Schumacker, B.

    1980-01-01

    The NASA Structural Analysis (NASTRAN) computer program is operational on the IBM 360/370 series computers. While execution of NASTRAN has been described and implemented under the virtual storage operating systems of the IBM 370 models, the IBM 370/168 computer can also operate in a time-sharing mode under the virtual machine operating system using the Conversational Monitor System (CMS) subset. The changes required to make NASTRAN operational under the CMS operating system are described.

  17. On IBM's Millennial Puzzle

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 5; Issue 10. On IBM's Millennial Puzzle. A Sarangarajan. Classroom Volume 5 Issue 10 October 2000 pp 81-89. Fulltext. Click here to view fulltext PDF. Permanent link: http://www.ias.ac.in/article/fulltext/reso/005/10/0081-0089. Author Affiliations.

  18. IBM Brazil: and environmental modern view

    Energy Technology Data Exchange (ETDEWEB)

    Cremonesi, Valter [IBM Brasil, Industria, Maquinas e Servicos Ltda., Rio de Janeiro, Rj (Brazil)

    1993-12-31

    Information of practical experiences on Environmental Affairs at IBM Brazil plant and branch offices is presented, with a modern view of the mission, resources, support, waste management, monitoring programs, recycling, energy conservation, partners programs, nature preservation 2rograms, recognitions and image. (author). 4 figs., 2 tabs.

  19. IBM SPSS Modeler cookbook

    CERN Document Server

    McCormick, Keith

    2013-01-01

    This is a practical cookbook with intermediate-advanced recipes for SPSS Modeler data analysts. It is loaded with step-by-step examples explaining the process followed by the experts.If you have had some hands-on experience with IBM SPSS Modeler and now want to go deeper and take more control over your data mining process, this is the guide for you. It is ideal for practitioners who want to break into advanced analytics.

  20. IBM announces global Grid computing solutions for banking, financial markets

    CERN Multimedia

    2003-01-01

    "IBM has announced a series of Grid projects around the world as part of its Grid computing program. They include IBM new Grid-based product offerings with business intelligence software provider SAS and other partners that address the computer-intensive needs of the banking and financial markets industry (1 page)."

  1. Lexicography for IBM

    Science.gov (United States)

    Engh, Jan

    In 1984, IBM and the University of Oslo set up a joint project, probably the first project of its kind in Norway. Its aim was to develop Norwegian language resources for IBM application software - for PCs, midrange computers, and mainframes. The primary objective: to create a “base dictionary” module that would drive language sensitive functions. The technology was based on simple character sequence recognition; its great asset being high compaction and rapid access to correct data. The module was to be built on documented linguistic forms. The dictionary should cover the general part of the vocabulary, and a broad coverage module was created for Norwegian Bokmål. Later, one module for Nynorsk was developed as well. At that stage, however, the project had become a regular IBM project. In the following years, other linguistic functions were added and eventually, the result served as the foundation for a grammar and for machine translation. The project was terminated because of the corporate financial crisis of the late 1980s. Later, the dictionaries were transferred to the University of Oslo. They are now an integral part of the basic infrastructure for Norwegian academic computational linguistics.

  2. Determining the degree of powder homogeneity using PC-based program

    Directory of Open Access Journals (Sweden)

    Đuragić Olivera M.

    2010-01-01

    Full Text Available The mixing of powders and the quality control of the obtained mixtures are critical operations involved in the processing of granular materials in chemical, metallurgical, food and pharmaceutical industries. Studies on mixing efficiency and the time needed for achieving homogeneity in the powder mashes production have significant importance. Depending on the characteristic of the materials, a number of methods have been used for the homogeneity tests. Very often, the degree of mixing has been determined by analyzing images of particle arrays in the sample using microscopy, photography and/or video tools. In this paper, a new PC-based method for determining the number of particles in the powder homogeneity tests has been developed. Microtracers®, red iron particles, were used as external tracer added before mixing. Iron particles in the samples of the mixtures were separated by rotary magnet and spread onto a filter paper. The filter paper was sprayed with 50% solution of ethanol for color development and the particles counted where the number of spots presented the concentration of added tracer. The number of spots was counted manually, as well as by the developed PC program. The program which analyzes scanned filter papers with spots is based on digital image analyses, where red spots were converted through few filters into a black and white, and counted. Results obtained by manual and PC counting were compared. A high correlation was established between the two counting methods.

  3. The GF11 project at IBM

    Science.gov (United States)

    Sexton, James C.

    1990-08-01

    The GF11 project at IBM's T. J. Watson Research Center is entering full production for QCD numerical calculations. This paper describes the GF11 hardware and system software, and discusses the first production program which has been developed to run on GF11. This program is a variation of the Cabbibo Marinari pure gauge Monte Carlo program for SU(3) and is currently sustaining almost 6 gigaflops on 360 processors in GF11.

  4. IBM 3480 tape cartridge

    CERN Multimedia

    1984-01-01

    The 3480 tape format is a magnetic tape data storage format developed by IBM. The cartridge contains a single reel. IBM’s 3480 cartridge tape system sought to replace the traditional reels of magnetic tape in the computer center. Because of their speed, reliability, durability and low media cost, these tapes and tape drives are still in high demand. A hallmark of the genre is transferability. Tapes recorded with one tape drive are generally readable on another drive, even if the tape drives were built by different manufacturers.

  5. Summary inside IBM's historic turnaround

    CERN Document Server

    2014-01-01

    This work offers a summary of the book "WHO SAYS ELEPHANTS CAN'T DANCE? Inside IBM's Historic Turnaround" by Louis Gerstner.In nine years as the chairman and CEO of International Business Machine Corporation (IBM), Louis Gerstner brought about a dramatic change in the company's fortunes. When he took charge, IBM was on the verge of extinction as the victim of rapid changes in the computer industry. However, instead of breaking up IBM as most analysts were suggesting, Gerstner and his management team turned the company around and restored it to a position of power and influence within the indu

  6. Cost-Estimation Program

    Science.gov (United States)

    Cox, Brian

    1995-01-01

    COSTIT computer program estimates cost of electronic design by reading item-list file and file containing cost for each item. Accuracy of cost estimate based on accuracy of cost-list file. Written by use of AWK utility for Sun4-series computers running SunOS 4.x and IBM PC-series and compatible computers running MS-DOS. The Sun version (NPO-19587). PC version (NPO-19157).

  7. Directions in parallel programming: HPF, shared virtual memory and object parallelism in pC++

    Science.gov (United States)

    Bodin, Francois; Priol, Thierry; Mehrotra, Piyush; Gannon, Dennis

    1994-01-01

    Fortran and C++ are the dominant programming languages used in scientific computation. Consequently, extensions to these languages are the most popular for programming massively parallel computers. We discuss two such approaches to parallel Fortran and one approach to C++. The High Performance Fortran Forum has designed HPF with the intent of supporting data parallelism on Fortran 90 applications. HPF works by asking the user to help the compiler distribute and align the data structures with the distributed memory modules in the system. Fortran-S takes a different approach in which the data distribution is managed by the operating system and the user provides annotations to indicate parallel control regions. In the case of C++, we look at pC++ which is based on a concurrent aggregate parallel model.

  8. IBM KELOMPOK USAHA SOUVENIR SABLON DIGITAL

    Directory of Open Access Journals (Sweden)

    Maria Krisnawati

    2015-02-01

    Full Text Available Targets to be achieved through IbM is on aspects of production and management. Aspects of the production which increased the production technology of making souvenirs, increasing capacity in the field of design through the program Corel Draw and Adobe Photoshop as well as consolidation of production procedures with due regard to health and safety work management. Management aspects namely on financial management, financial management hold good with regular bookkeeping, through marketing management produces forms of promotion through various media. Market network expansion and facilitate consumer access to order products.Through HR management can improve the training of human resources, the provision of entrepreneurial motivation and self empowerment. IbM implemented through phases 1 Preparation ; 2 Stage Assessment ; 3 The Plan or Program Activity; 4 Phase Action Plan ; 5 Implementation Phase or activity ; and 6 Evaluation Phase . It is expected to be implemented through the stages can help solve problems and realize the needs of partners.

  9. 8-inch IBM floppy disk

    CERN Multimedia

    1971-01-01

    The 8-inch floppy disk was a magnetic storage disk for the data introduced commercially by IBM in 1971. It was designed by an IBM team as an inexpensive way to load data into the IBM System / 370. Plus it was a read-only bare disk containing 80 KB of data. The first read-write version was introduced in 1972 by Memorex and could contain 175 KB on 50 tracks (with 8 sectors per track). Other improvements have led to various coatings and increased capacities. Finally, it was surpassed by the mini diskette of 5.25 inches introduced in 1976.

  10. The Program Manager’s Support System (PMSS). An Executive Overview and Descriptions of Functional Modules

    Science.gov (United States)

    1989-05-01

    50 Program Office Organization and Staffing Module 50 Expert Systems for Acquisition Strategies 51 Procurement Document Generator Module 51...PC; Z-248 50 trade-off analysis Program Office Organization PROS Develop PMO organization Prototype IBM-PC; Z-248 50 and Staffing charts, on board...prototype moduie. It requires a color graphics card. Program Office Organization and Staffing (PROS) Module The Program Office Organization and Staffing

  11. Microcomputer programs for particulate control: section failure; baghouse; plume opacity prediction; and in-stack opacity calculator. Software

    Energy Technology Data Exchange (ETDEWEB)

    Sparks, L.E.

    1985-09-01

    IBM-PC usable versions of several computer models useful in particulate control are provided. The models were originally written for the TRS-80 Model I-III series of microcomputers and have been translated to run on the IBM-PC. The documentation for the TRS-80 versions applies to the IBM-PC versions. The programs are written in FORTRAN and are provided in both source (FORTRAN) and executable form. Some small machine language routines are used to format the screen for data entry. These routines limit the programs to IBM-PC and close clones. The minimum hardware requirements are 256K IBM-PC or close clone, a monochrome monitor, and a disk drive. A printer is useful but not required. The following computer programs are provided in the four-disk package: (1) ESP section failure model, (2) GCA/EPA baghouse model, (3) Plume opacity prediction model, and (4) In-stack opacity calculator. All the models are documented in EPA report Microcomputer Programs for Particulate Control, EPA-600/8-85-025a (PB86-146529). The models provide useful tools for those involved in particulate control.

  12. Description of a multi-university education and collaborative care child psychiatry access program: New York State's CAP PC.

    Science.gov (United States)

    Kaye, D L; Fornari, V; Scharf, M; Fremont, W; Zuckerbrot, R; Foley, C; Hargrave, T; Smith, B A; Wallace, J; Blakeslee, G; Petras, J; Sengupta, S; Singarayer, J; Cogswell, A; Bhatia, I; Jensen, P

    2017-09-01

    Although, child mental health problems are widespread, few get adequate treatment, and there is a severe shortage of child psychiatrists. To address this public health need many states have adopted collaborative care programs to assist primary care to better assess and manage pediatric mental health concerns. This report adds to the small literature on collaborative care programs and describes one large program that covers most of New York state. CAP PC, a component program of New York State's Office of Mental Health (OMH) Project TEACH, has provided education and consultation support to primary care providers covering most of New York state since 2010. The program is uniquely a five medical school collaboration with hubs at each that share one toll free number and work together to provide education and consultation support services to PCPs. The program developed a clinical communications record to track information about all consultations which forms the basis of much of this report. 2-week surveys following consultations, annual surveys, and pre- and post-educational program evaluations have also been used to measure the success of the program. CAP PC has grown over the 6years of the program and has provided 8013 phone consultations to over 1500 PCPs. The program synergistically provided 17,523 CME credits of educational programming to 1200 PCPs. PCP users of the program report very high levels of satisfaction and self reported growth in confidence. CAP PC demonstrates that large-scale collaborative consultation models for primary care are feasible to implement, popular with PCPs, and can be sustained. The program supports increased access to child mental health services in primary care and provides child psychiatric expertise for patients who would otherwise have none. Copyright © 2017. Published by Elsevier Inc.

  13. Basic program relates tube wall thickness and pressure

    Energy Technology Data Exchange (ETDEWEB)

    Ganapathy, V.

    1985-11-01

    A computer program, written in BASIC, which calculates safe tube pressures and necessary wall thickness is discussed. Two examples of this process are given. Computer input lists and results are presented. The program is compatible with IBM PC and similar units.

  14. Work with Apple's Rhapsody Operating System which Allows Simultaneous UNIX Program Development, UNIX Program Execution, and PC Application Execution

    CERN Document Server

    Summers, D; Cremaldi, L M; Sanders, D; Summers, Don; Riley, Chris; Cremaldi, Lucien; Sanders, David

    2001-01-01

    Over the past decade, UNIX workstations have provided a very powerful program development environment. However, workstations are more expensive than PCs and Macintoshes and require a system manager for day-to-day tasks such as disk backup, adding users, and setting up print queues. Native commercial software for system maintenance and "PC applications" has been lacking under UNIX. Apple's new Rhapsody operating system puts the current MacOS on a NeXT UNIX foundation and adds an enhanced NeXTSTEP object oriented development environment called Yellow Box. Rhapsody simultaneously runs UNIX and commercial Macintosh applications such as word processing or spreadsheets. Thus a UNIX detector Monte Carlo can run for days in the background at the same time as a commercial word processing program. And commercial programs such as Dantz Retrospect are being made available to make disk backup easy under Rhapsody. Apple has announced that in 1999 they intend to be running Rhapsody, or MacOS X as it will be called in the co...

  15. The Impact of IBM Cell Technology on the Programming Paradigm in the Context of Computer Systems for Climate and Weather Models

    Energy Technology Data Exchange (ETDEWEB)

    Zhou, Shujia; Duffy, Daniel; Clune, Thomas; Suarez, Max; Williams, Samuel; Halem, Milton

    2009-01-10

    The call for ever-increasing model resolutions and physical processes in climate and weather models demands a continual increase in computing power. The IBM Cell processor's order-of-magnitude peak performance increase over conventional processors makes it very attractive to fulfill this requirement. However, the Cell's characteristics, 256KB local memory per SPE and the new low-level communication mechanism, make it very challenging to port an application. As a trial, we selected the solar radiation component of the NASA GEOS-5 climate model, which: (1) is representative of column physics components (half the total computational time), (2) has an extremely high computational intensity: the ratio of computational load to main memory transfers, and (3) exhibits embarrassingly parallel column computations. In this paper, we converted the baseline code (single-precision Fortran) to C and ported it to an IBM BladeCenter QS20. For performance, we manually SIMDize four independent columns and include several unrolling optimizations. Our results show that when compared with the baseline implementation running on one core of Intel's Xeon Woodcrest, Dempsey, and Itanium2, the Cell is approximately 8.8x, 11.6x, and 12.8x faster, respectively. Our preliminary analysis shows that the Cell can also accelerate the dynamics component (~;;25percent total computational time). We believe these dramatic performance improvements make the Cell processor very competitive as an accelerator.

  16. IBM SmartCloud essentials

    CERN Document Server

    Schouten, Edwin

    2013-01-01

    A practical, user-friendly guide that provides an introduction to cloud computing using IBM SmartCloud, along with a thorough understanding of resource management in a cloud environment.This book is great for anyone who wants to get a grasp of what cloud computing is and what IBM SmartCloud has to offer. If you are an IT specialist, IT architect, system administrator, or a developer who wants to thoroughly understand the cloud computing resource model, this book is ideal for you. No prior knowledge of cloud computing is expected.

  17. IBM KELOMPOK USAHA SOUVENIR SABLON DIGITAL

    Directory of Open Access Journals (Sweden)

    Maria krisnawati

    2015-12-01

    Full Text Available Kegiatan IbM dilaksanakan pada kelompok souvenir sablon digital di Desa Sidodadi dan Karanglo Kecamatan Tawangnangu Kabupaten Karanganyar. Kegiatan ini bertujuan untuk: 1 meningkatkan motivasi wirausaha mitra; 2 meningkatkan pemahaman mitra tentang perencanaan bisnis dan manajemen usaha; 3 meningkatkan kemampuan SDM dalam teknik produksi dan pemasaran; serta 4 mengembangkan jejaring kewirausahaan pemuda untuk menopang pengembangan ekonomi kreatif. Target yang akan dicapai melalui IbM adalah pada aspek produksi dan manajemen. Aspek produksi, yaitu meningkatnya teknologi produksi pembuatan souvenir, meningkatnya kemampuan dalam bidang desain melalui program corel draw dan Adobe photoshop serta pemantapan prosedur produksi dengan memperhatikan kesehatan dan keselamatan kerja. Aspek manajemen, yaitu pada manajemen keuangan, mengadakan pengelolaaan keuangan yang baik dengan pembukuan yang teratur, melalui manajemen pemasaran menghasilkan bentuk-bentuk promosi melalui berbagai media, perluasan jaringan pasar dan mempermudah akses konsumen memesan produk. Melalui manajemen SDM dapat meningkatkan kemampuan SDM dengan pelatihan, pemberian motivasi wirausaha dan pemberdayaan diri.Kegiatan IbM dilaksanakan melalui tahapan 1 Tahap Persiapan; 2 Tahap Assesment; 3 Tahap Perencanaan Program atau Kegiatan; 4 Tahap Pemformulasian Rencana Aksi; 5 Tahap Pelaksanaan (Implementasi Program atau Kegiatan; serta 6 Tahap Evaluasi. Diharapkan melalui tahapan yang akan dilaksanakan dapat membantu menyelesaikan permasalahan dan memenuhi kebutuhan mitra.Kata kunci : IbM, pelatihan, pembinaan, pendampingan, souvenir, sablon digital.

  18. Performing data analysis using IBM SPSS

    CERN Document Server

    Meyers, Lawrence S; Guarino, A J

    2013-01-01

    This book is designed to be a user's guide for students and other interested readers to perform statistical data analysis with IBM SPSS, which is a major statistical software package used extensively in academic, government, and business settings. This book addresses the needs, level of sophistication, and interest in introductory statistical methodology on the part of undergraduate and graduate students in social and behavioral science, business, health-related, and education programs.  Each chapter covers a particular statistical procedure and has the following format: an example pr

  19. Making IBM's Computer, Watson, Human

    Science.gov (United States)

    Rachlin, Howard

    2012-01-01

    This essay uses the recent victory of an IBM computer (Watson) in the TV game, "Jeopardy," to speculate on the abilities Watson would need, in addition to those it has, to be human. The essay's basic premise is that to be human is to behave as humans behave and to function in society as humans function. Alternatives to this premise are considered…

  20. Data Discovery with IBM Watson

    Science.gov (United States)

    Fessler, J.

    2016-12-01

    BM Watson is a cognitive computing system that uses machine learning, statistical analysis, and natural language processing to find and understand the clues in questions posed to it. Watson was made famous when it bested two champions on TV's Jeopardy! show. Since then, Watson has evolved into a platform of cognitive services that can be trained on very granular fields up study. Watson is being used to support a number of subject domains, such as cancer research, public safety, engineering, and the intelligence community. IBM will be providing a presentation and demonstration on the Watson technology and will discuss its capabilities including Natural Language Processing, text analytics and enterprise search, as well as cognitive computing with deep Q&A. The team will also be giving examples of how IBM Watson technology is being used to support real-world problems across a number of public sector agencies

  1. CARES/PC - CERAMICS ANALYSIS AND RELIABILITY EVALUATION OF STRUCTURES

    Science.gov (United States)

    Szatmary, S. A.

    1994-01-01

    when the maximum likelihood technique is used. CARES/PC is written and compiled with the Microsoft FORTRAN v5.0 compiler using the VAX FORTRAN extensions and dynamic array allocation supported by this compiler for the IBM/MS-DOS or OS/2 operating systems. The dynamic array allocation routines allow the user to match the number of fracture sets and test specimens to the memory available. Machine requirements include IBM PC compatibles with optional math coprocessor. Program output is designed to fit 80-column format printers. Executables for both DOS and OS/2 are provided. CARES/PC is distributed on one 5.25 inch 360K MS-DOS format diskette in compressed format. The expansion tool PKUNZIP.EXE is supplied on the diskette. CARES/PC was developed in 1990. IBM PC and OS/2 are trademarks of International Business Machines. MS-DOS and MS OS/2 are trademarks of Microsoft Corporation. VAX is a trademark of Digital Equipment Corporation.

  2. Ibm BAGI GURU DAN SISWA SMU SETIA BUDI SEMARANG

    OpenAIRE

    Adhi Kusmantoro; Agus Nuwolo

    2016-01-01

    Dalam dunia industri ada beberapasistem yang digunakan dalam mengoperasikan sistem pengendalielektromagnetik, antara lain sistem pengoperasian secara manual, semi otomatisdan otomatis.Tujuan pengabdian masyarakat di SMU Setia Budi Semarang adalah untuk memberikan kemampuan penggunaan software EKTS dan menambah pengetahuan atau wawasan teknik pengendali listrik di industri yang sedang berkembang dan banyak dipakai. Metode pelaksanaan kegiatan program Iptek bagi Masyarakat (IbM) yang digunakan ...

  3. Guide to VAX, CDC, and IBM 3090 Third Edition

    Energy Technology Data Exchange (ETDEWEB)

    Parsa, Zohreh [Brookhaven National Lab. (BNL), Upton, NY (United States)

    1987-05-01

    This guide was originally edited for the users of DUA0: [PARSA1] Accelerator Physics programs directory. In response to a large number of requests from a broader audience the previous edition is updated, and new sections on IBM 3090 and Network and Communications have been added. (This is a collection of notes and definitions from guides, reference manuals, and help files).

  4. The PC graphics handbook

    CERN Document Server

    Sanchez, Julio

    2003-01-01

    Part I - Graphics Fundamentals PC GRAPHICS OVERVIEW History and Evolution Short History of PC Video PS/2 Video Systems SuperVGA Graphics Coprocessors and Accelerators Graphics Applications State-of-the-Art in PC Graphics 3D Application Programming Interfaces POLYGONAL MODELING Vector and Raster Data Coordinate Systems Modeling with Polygons IMAGE TRANSFORMATIONS Matrix-based Representations Matrix Arithmetic 3D Transformations PROGRAMMING MATRIX TRANSFORMATIONS Numeric Data in Matrix Form Array Processing PROJECTIONS AND RENDERING Perspective The Rendering Pipeline LIGHTING AND SHADING Lightin

  5. Integrated Building Management System (IBMS)

    Energy Technology Data Exchange (ETDEWEB)

    Anita Lewis

    2012-07-01

    This project provides a combination of software and services that more easily and cost-effectively help to achieve optimized building performance and energy efficiency. Featuring an open-platform, cloud- hosted application suite and an intuitive user experience, this solution simplifies a traditionally very complex process by collecting data from disparate building systems and creating a single, integrated view of building and system performance. The Fault Detection and Diagnostics algorithms developed within the IBMS have been designed and tested as an integrated component of the control algorithms running the equipment being monitored. The algorithms identify the normal control behaviors of the equipment without interfering with the equipment control sequences. The algorithms also work without interfering with any cooperative control sequences operating between different pieces of equipment or building systems. In this manner the FDD algorithms create an integrated building management system.

  6. IBM KELOMPOK TANI LIDAH BUAYA

    Directory of Open Access Journals (Sweden)

    Sri Rahayu Prastyaningsih

    2017-04-01

    Full Text Available The cultivation of aloe vera plants began since residents in Pekanbaru know of the benefits of aloe vera plant. The group of Lidah Buaya Kita was formed in January 2014 in the District Rumbai, Pekanbaru City, Riau Province. The first time, farmers only sell seedling and leaves of aloe vera, then they make crackers and tea from leaves its own garden, where product of crackers and tea  can add value to the business as one of  product processed of the aloe vera plant. Partners also requested training for make drinks aloe vera. The aims of this IBM (1 make drinks aloe vera (2 techniques of processing crackers use machine flour mixer (3 Products get permits from the Dinas Kesehatan (4 analyze the nutrients and chemical of crackers and tea product  (5 Make packaging of drinks, crackers and tea aloe vera (6 the promotion and marketing of aloe vera products (7 business analysis of product.IbM was implemented in 2016. Our Patners was aloe vera farmers in (1 RW 02 kelurahan Lembah Damai (2 RW 04 kelurahan Lembah Sari. The result of our IbM was (1 the partner be able to make a drink aloe vera. (2 partners have cup sealer and  flour mixer machine to support their production. (3 partner has the brand, license P-IRT and test nutrient/chemical content (4 the partner is able to package the aoe vera  product and ready for market (5 partners can promote aloe vera product.The cultivation of aloe vera plants began since residents in Pekanbaru know of the benefits of aloe vera plant. The group of Lidah Buaya Kita was formed in January 2014 in the District Rumbai, Pekanbaru City, Riau Province. The first time, farmers only sell seedling and leaves of aloe vera, then they make crackers and tea from leaves its own garden, where product of crackers and tea  can add value to the business as one of  product processed of the aloe vera plant. Partners also requested training for make drinks aloe vera. The aims of this IBM (1 make drinks aloe vera (2 techniques of

  7. IBM Sametime 852 Administration Guide

    CERN Document Server

    Davis, Gabriella; Duff, Thomas

    2011-01-01

    The IBM Lotus Sametime 8.5.2 Administration Guide uses a practical, no-nonsense approach to give you the essential information you need. Using realistic scenarios, you learn how to configure and maintain your environment to meet your needs and take advantage of the flexibility offered in Sametime 8.5.2. If you are responsible for installing and administering Sametime 8.5.2, then this book is for you. If you're completely new to Sametime administration, this book will serve as your roadmap. If you're making the jump from a prior version of Sametime, then you'll see how Sametime 8.5.2 differs an

  8. PC Pricer

    Data.gov (United States)

    U.S. Department of Health & Human Services — The PC Pricer is a tool used to estimate Medicare PPS payments. The final payment may not be precise to how payments are determined in the Medicare claims processing...

  9. Economic-Analysis Program for a Communication System

    Science.gov (United States)

    Chamberlain, R. G.

    1986-01-01

    Prices and profits of alternative designs compared. Objective of Land Mobile Satellite Service Finance Report (LMSS) program is to provide means for comparing alternative designs of LMSS systems. Program is Multiplan worksheet program. Labels used in worksheet chosen for satellite-based cellular communication service, but analysis not restricted to such cases. LMSS written for interactive execution with Multiplan (version 1.2) and implemented on IBM PC series computer operating under DOS (version 2.11).

  10. A PC program for estimating measurement uncertainty for aeronautics test instrumentation

    Science.gov (United States)

    Blumenthal, Philip Z.

    1995-01-01

    A personal computer program was developed which provides aeronautics and operations engineers at Lewis Research Center with a uniform method to quickly provide values for the uncertainty in test measurements and research results. The software package used for performing the calculations is Mathcad 4.0, a Windows version of a program which provides an interactive user interface for entering values directly into equations with immediate display of results. The error contribution from each component of the system is identified individually in terms of the parameter measured. The final result is given in common units, SI units, and percent of full scale range. The program also lists the specifications for all instrumentation and calibration equipment used for the analysis. It provides a presentation-quality printed output which can be used directly for reports and documents.

  11. A PC program to optimize system configuration for desired reliability at minimum cost

    Science.gov (United States)

    Hills, Steven W.; Siahpush, Ali S.

    1994-01-01

    High reliability is desired in all engineered systems. One way to improve system reliability is to use redundant components. When redundant components are used, the problem becomes one of allocating them to achieve the best reliability without exceeding other design constraints such as cost, weight, or volume. Systems with few components can be optimized by simply examining every possible combination but the number of combinations for most systems is prohibitive. A computerized iteration of the process is possible but anything short of a super computer requires too much time to be practical. Many researchers have derived mathematical formulations for calculating the optimum configuration directly. However, most of the derivations are based on continuous functions whereas the real system is composed of discrete entities. Therefore, these techniques are approximations of the true optimum solution. This paper describes a computer program that will determine the optimum configuration of a system of multiple redundancy of both standard and optional components. The algorithm is a pair-wise comparative progression technique which can derive the true optimum by calculating only a small fraction of the total number of combinations. A designer can quickly analyze a system with this program on a personal computer.

  12. IBM USAHA KREATIF KELUARGA MISKIN (GAKIN

    Directory of Open Access Journals (Sweden)

    Titiek Ambarwati

    2016-11-01

    Full Text Available Kreativitas masyarakat di Kelurahan Gading Kasri terutama ibu rumah tangga, dan remaja putri putus sekolah kurang dalam menciptakan kegiatan kelompok yang dapat menghasilkan pendapatan, sehingga penting dijadikan mitra kegiatan pengabdian kepada masyarakat. Tujuan yang di diharapkan dari program IbM Usaha Kreatif Keluarga Miskin di Kelurahan Gading Kasri Kecamatan Klojen Malang adalah meningkatkan pengetahuan intrapreneurship dalam pengelolaannya bagi kedua mitra sasaran, meningkatkan kemampuan manajerial, dan memiliki kemandirian dan mampu bekerjasama dengan prinsip saling menguntungkan dengan pihak lain. Metode yang digunakan adalah pelatihan dan pendampingan secara berkelanjutan. Hasil kegiatan pengabdian ini adalah, bahwa mitra kerja merasakan bahwa kegiatan pengabdian ini dapat meningkatkan kualitas produk usaha kreatif sehingga dapat dijadikan sebagai mata pencaharian sambilan melainkan dapat dijadikan sebagai mata pencaharian utama atau lahan berwirausaha. Bertambahnya pengetahuan mitra kerja mengenai pola dan mode pakaian, sehingga usaha jasa jahitnya sebagai mata pencaharian dapat dikembangkan dan pelanggannya semakin meningkat. Dan Meningkatnya ketrampilan pengelolaan manajemen usaha yang lebih profesional mulai pengelolaan manajemen sumberdaya manusia, manajemen produksi, pengelolaan sistem administrasi, serta manajemen pemasaran.

  13. PC Based Display for Sonar Applications: A Design Experience

    OpenAIRE

    G. Miny; Anney Morris; M.A. Jayendran; A. Unnikrishnan

    1994-01-01

    An attempt was made to standardise the hardware and the software used for the sonar display systems. The idea of standardise hardware suggested itself in using an IBM-compatible PC AT which configures with an Intel 80386 CPU and a standard VGA display adapter card. The software consists of Intel assembly procedures embedded in a PASCAL (turbo 4.0) environment.

  14. The IBM i Programmer's Guide to PHP

    CERN Document Server

    Olen, Jeff

    2012-01-01

    This is the first book to comprehensively address PHP and how it can-and should-be deployed on the IBM i. With this IBM i-specific point of view, the authors examine how to transfer skills from a green screen environment to the Web, become intimately familiar with PHP's commonly used features, and help start down the road of highly interactive Web-based application development. For decades, the green screen has been the ubiquitous interface into an organization's data. But with the advent of HTML, the Internet, and the browser, combined with the end user's existing familiarity with the Web,

  15. Graphics Gems III IBM version

    CERN Document Server

    Kirk, David

    1994-01-01

    This sequel to Graphics Gems (Academic Press, 1990), and Graphics Gems II (Academic Press, 1991) is a practical collection of computer graphics programming tools and techniques. Graphics Gems III contains a larger percentage of gems related to modeling and rendering, particularly lighting and shading. This new edition also covers image processing, numerical and programming techniques, modeling and transformations, 2D and 3D geometry and algorithms,ray tracing and radiosity, rendering, and more clever new tools and tricks for graphics programming. Volume III also includes a

  16. GNE mutations in an American family with quadriceps-sparing IBM and lack of mutations in s-IBM.

    Science.gov (United States)

    Vasconcelos, Olavo M; Raju, Raghavan; Dalakas, Marinos C

    2002-12-10

    Analysis for GNE mutations was performed in an American, non-Iranian Jewish, family with quadriceps-sparing inclusion body myopathy (QS-IBM) and in 11 patients with sporadic IBM (s-IBM). Two novel nonallosteric site missense mutations were found in the QS-IBM kinship. No mutations were identified in s-IBM patients. After 8 years of follow-up and severe disease progression, the quadriceps muscle in the QS-IBM patient remains strong despite subclinical involvement documented with repeat MRI and muscle biopsy.

  17. A MAP fixed-point, packing-unpacking routine for the IBM 7094 computer

    Science.gov (United States)

    Robert S. Helfman

    1966-01-01

    Two MAP (Macro Assembly Program) computer routines for packing and unpacking fixed point data are described. Use of these routines with Fortran IV Programs provides speedy access to quantities of data which far exceed the normal storage capacity of IBM 7000-series computers. Many problems that could not be attempted because of the slow access-speed of tape...

  18. Miks IBM müüb kroonijuveeli? / Valdo Randpere

    Index Scriptorium Estoniae

    Randpere, Valdo, 1958-

    2004-01-01

    Kuna konkurents on väga tihe, siis IBM loobub väikese marginaaliga personaalarvutite ärist ning keskendub serveritele ja keerukatele ärilahendustele. Lisa: IBM müüb personaalarvutite divisjoni hiinlastele

  19. Hazardous Waste Cleanup: IBM Corporation, Former in Owego, New York

    Science.gov (United States)

    The corrective action activities at the facility are conducted by IBM Corporation, therefore IBM is listed as the operator of the Part 373 Hazardous Waste Management (HWM) Permit for corrective action. Lockheed Martin Corporation owns the facility and is l

  20. PC-SEAPAK - ANALYSIS OF COASTAL ZONE COLOR SCANNER AND ADVANCED VERY HIGH RESOLUTION RADIOMETER DATA

    Science.gov (United States)

    Mcclain, C. R.

    1994-01-01

    incompatibilities between the MVP-AT image board and ZENITH computers. Also, the MVP-AT image board is not necessarily compatible with 486-based systems; users of 486-based systems should consult with Matrox about compatibility concerns. Other PC-SEAPAK requirements include a Microsoft mouse (serial version), 2Mb RAM, and 100Mb hard disk space. For data ingest and backup, 9-track tape, 8mm tape and optical disks are supported and recommended. PC-SEAPAK has been under development since 1988. Version 4.0 was updated in 1992, and is distributed without source code. It is available only as a set of 36 1.2Mb 5.25 inch IBM MS-DOS format diskettes. PC-SEAPAK is a copyrighted product with all copyright vested in the National Aeronautics and Space Administration. Phar Lap's DOS_Extender run-time version is integrated into several of the programs; therefore, the PC-SEAPAK programs may not be duplicated. Three of the distribution diskettes contain DOS_Extender files. One of the distribution diskettes contains Media Cybernetics' HALO88 font files, also licensed by NASA for dissemination but not duplication. IBM is a registered trademark of International Business Machines. MS-DOS is a registered trademark of Microsoft Corporation. HALO88 is a registered trademark of Media Cybernetics, but the product was discontinued in 1991.

  1. The Early Overseas Activities of IBM in Japan

    OpenAIRE

    吉沢, 正広; 田中, 雅章; Masahiro, YOSHIZAWA; Masaaki, TANAKA; 愛知学院大学; 鈴鹿短期大学; / SUZUKA JUNIOR COLLEGE

    1998-01-01

    The purpose of this paper is to examine how IBM entered into prewar Japan and ran its wholly-owned subsidiary thereafter. Before examining something noted above, this paper surveys the process of formation of IBM and then traces its early overseas activities. Turning to the initial contacts between Japan and IBM, at first IBM carried out its mere export trade to Japan through Morimura and then Kurosawa. IBM then established its wholly-owned subsidiary, Japan Watson,in Japan to expand the busi...

  2. IBM, Elsevier Science, and academic freedom.

    Science.gov (United States)

    Bailar, John C; Cicolella, Andre; Harrison, Robert; LaDou, Joseph; Levy, Barry S; Rohm, Timothy; Teitelbaum, Daniel T; Wang, Yung-Der; Watterson, Andrew; Yoshida, Fumikazu

    2007-01-01

    Elsevier Science refused to publish a study of IBM workers that IBM sought to keep from public view. Occupational and environmental health (OEH) suffers from the absence of a level playing field on which science can thrive. Industry pays for a substantial portion of OEH research. Studies done by private consulting firms or academic institutions may be published if the results suit the sponsoring companies, or they may be censored. OEH journals often reflect the dominance of industry influence on research in the papers they publish, sometimes withdrawing or modifying papers in line with industry and advertising agendas. Although such practices are widely recognized, no fundamental change is supported by government and industry or by professional organizations.

  3. IBM Watson Analytics: Automating Visualization, Descriptive, and Predictive Statistics.

    Science.gov (United States)

    Hoyt, Robert Eugene; Snider, Dallas; Thompson, Carla; Mantravadi, Sarita

    2016-10-11

    We live in an era of explosive data generation that will continue to grow and involve all industries. One of the results of this explosion is the need for newer and more efficient data analytics procedures. Traditionally, data analytics required a substantial background in statistics and computer science. In 2015, International Business Machines Corporation (IBM) released the IBM Watson Analytics (IBMWA) software that delivered advanced statistical procedures based on the Statistical Package for the Social Sciences (SPSS). The latest entry of Watson Analytics into the field of analytical software products provides users with enhanced functions that are not available in many existing programs. For example, Watson Analytics automatically analyzes datasets, examines data quality, and determines the optimal statistical approach. Users can request exploratory, predictive, and visual analytics. Using natural language processing (NLP), users are able to submit additional questions for analyses in a quick response format. This analytical package is available free to academic institutions (faculty and students) that plan to use the tools for noncommercial purposes. To report the features of IBMWA and discuss how this software subjectively and objectively compares to other data mining programs. The salient features of the IBMWA program were examined and compared with other common analytical platforms, using validated health datasets. Using a validated dataset, IBMWA delivered similar predictions compared with several commercial and open source data mining software applications. The visual analytics generated by IBMWA were similar to results from programs such as Microsoft Excel and Tableau Software. In addition, assistance with data preprocessing and data exploration was an inherent component of the IBMWA application. Sensitivity and specificity were not included in the IBMWA predictive analytics results, nor were odds ratios, confidence intervals, or a confusion matrix

  4. EXPLOSION AIRBLAST PROGRAM "BLASTO", FOR WEATHER-DEPENDENT PREDICTIONS ON A PERSONAL COMPUTER

    OpenAIRE

    Reed, J.

    1990-01-01

    An airblast prediction program for explosions, called BLASTO has been written for use with IBM-PC (or compatible) computers, to produce overpressure-distance curves for a variety of interactive input conditions. Several common units are allowed for each input, but calculation and output are in SI metric units. Explosion yield (chemical or nuclear) and ambient atmospheric pressure are used to generate a referenced 'Standard' overpressure-distance curve. Explosives may be point charges at any h...

  5. Demonstration ofentanglement assisted invarianceon IBM's quantum experience.

    Science.gov (United States)

    Deffner, Sebastian

    2017-11-01

    Quantum entanglement is among the most fundamental, yet from classical intuition also most surprising properties of the fully quantum nature of physical reality. We report several experiments performed on IBM's Quantum Experience demonstrating envariance - entanglement assisted invariance. Envariance is a recently discovered symmetry of composite quantum systems, which is at the foundational origin of physics and a quantum phenomenon of pure states. These very easily reproducible and freely accessible experiments on Quantum Experience provide simple tools to study the properties of envariance, and we illustrate this for several cases with "quantum universes" consisting of up to five qubits.

  6. IBM SPSS statistics 19 made simple

    CERN Document Server

    Gray, Colin D

    2012-01-01

    This new edition of one of the most widely read textbooks in its field introduces the reader to data analysis with the most powerful and versatile statistical package on the market: IBM SPSS Statistics 19. Each new release of SPSS Statistics features new options and other improvements. There remains a core of fundamental operating principles and techniques which have continued to apply to all releases issued in recent years and have been proved to be worth communicating in a small volume. This practical and informal book combines simplicity and clarity of presentation with a comprehensive trea

  7. Ibm BAGI GURU DAN SISWA SMU SETIA BUDI SEMARANG

    Directory of Open Access Journals (Sweden)

    Adhi Kusmantoro

    2016-06-01

    Full Text Available Dalam dunia industri ada beberapasistem yang digunakan dalam mengoperasikan sistem pengendalielektromagnetik, antara lain sistem pengoperasian secara manual, semi otomatisdan otomatis.Tujuan pengabdian masyarakat di SMU Setia Budi Semarang adalah untuk memberikan kemampuan penggunaan software EKTS dan menambah pengetahuan atau wawasan teknik pengendali listrik di industri yang sedang berkembang dan banyak dipakai. Metode pelaksanaan kegiatan program Iptek bagi Masyarakat (IbM yang digunakan adalah metode pelatihan yang dibagi dalam tiga tahap, yaitu pelatihan secara teori, pelatihan menggunakan softawre EKTS dan beberapa rancangan pengendali motor listrik, dan tahap evaluasi dalam kegiatan awal sampai dengan akhir. Dalam kegiatan pengabdian masyarakat di SMU Setia Budi Semarang telah dibuat pengendali start stop, pengendali motor berurutan, dan pengendali membalik putaran motor listrik. ?é?á Kata Kunci : EKTS, motor listrik, kontaktor magnet

  8. Program for the thermal design and simulation of the operation of a steam condenser for thermal and nuclear power stations and its application to the condenser at the Cofrentes nuclear power station

    Energy Technology Data Exchange (ETDEWEB)

    Garcia Bartual, R.; Pallares Huici, E.

    A program is being developed for an IBM-PC or AT computer based on a calculation system which synthesises the heat transfer process which takes place in the steam condensors at conventional thermal power stations. The program incorporates a useful tool capable of representing characteristic operating curves for a given condensor. Describes its application to the steam condenser at the Cofrentes nuclear power station. 4 refs., 5 tabs., 8 figs.

  9. ALPS - A LINEAR PROGRAM SOLVER

    Science.gov (United States)

    Viterna, L. A.

    1994-01-01

    Linear programming is a widely-used engineering and management tool. Scheduling, resource allocation, and production planning are all well-known applications of linear programs (LP's). Most LP's are too large to be solved by hand, so over the decades many computer codes for solving LP's have been developed. ALPS, A Linear Program Solver, is a full-featured LP analysis program. ALPS can solve plain linear programs as well as more complicated mixed integer and pure integer programs. ALPS also contains an efficient solution technique for pure binary (0-1 integer) programs. One of the many weaknesses of LP solvers is the lack of interaction with the user. ALPS is a menu-driven program with no special commands or keywords to learn. In addition, ALPS contains a full-screen editor to enter and maintain the LP formulation. These formulations can be written to and read from plain ASCII files for portability. For those less experienced in LP formulation, ALPS contains a problem "parser" which checks the formulation for errors. ALPS creates fully formatted, readable reports that can be sent to a printer or output file. ALPS is written entirely in IBM's APL2/PC product, Version 1.01. The APL2 workspace containing all the ALPS code can be run on any APL2/PC system (AT or 386). On a 32-bit system, this configuration can take advantage of all extended memory. The user can also examine and modify the ALPS code. The APL2 workspace has also been "packed" to be run on any DOS system (without APL2) as a stand-alone "EXE" file, but has limited memory capacity on a 640K system. A numeric coprocessor (80X87) is optional but recommended. The standard distribution medium for ALPS is a 5.25 inch 360K MS-DOS format diskette. IBM, IBM PC and IBM APL2 are registered trademarks of International Business Machines Corporation. MS-DOS is a registered trademark of Microsoft Corporation.

  10. FREQFIT: Computer program which performs numerical regression and statistical chi-squared goodness of fit analysis

    Energy Technology Data Exchange (ETDEWEB)

    Hofland, G.S.; Barton, C.C.

    1990-10-01

    The computer program FREQFIT is designed to perform regression and statistical chi-squared goodness of fit analysis on one-dimensional or two-dimensional data. The program features an interactive user dialogue, numerous help messages, an option for screen or line printer output, and the flexibility to use practically any commercially available graphics package to create plots of the program`s results. FREQFIT is written in Microsoft QuickBASIC, for IBM-PC compatible computers. A listing of the QuickBASIC source code for the FREQFIT program, a user manual, and sample input data, output, and plots are included. 6 refs., 1 fig.

  11. Training in the Workplace: An IBM Case Study. Contractor Report.

    Science.gov (United States)

    Grubb, Ralph E.

    International Business Machines Corporation's (IBM) efforts to develop a corporate culture are associated with its founder, Thomas J. Watson, Sr. From the start of his association with the company in 1914, the importance of education was stressed. The expansion of the education and training organization paralleled IBM's 75-year growth. In January…

  12. Hazardous Waste Cleanup: IBM Corporation in Dayton, New Jersey

    Science.gov (United States)

    The IBM facility is located at 431 Ridge Road on a 66-acre parcel in a mixed residential and industrial section of Dayton, South Brunswick Township, Middlesex County, New Jersey. IBM's manufacturing plant was constructed in 1956 and used until 1985 for

  13. Dynamics of Innovation at IBM, 1945-1953

    DEFF Research Database (Denmark)

    Heide, Lars

    The paper explores the use of sociotechnical network and sensemaking theory in early early innovation of computer technology at IBM to improve the understanding of the dynamics in innovation processes through the study of individuals’ contributions in a large company. It complements Actor Network...... Theory by Karl E. Weick’s sensemaking and studies innovation processes through narratives. This approach supplements the literature’s institutional focus and provides more focus on the technology’s use and limitations on innovations. In the mid-1940s, IBM was reluctant to engage in computer innovation......, IBM did not have its blinds down and provided resources for several groups of engineers exploring substituting electromechanical elements by electronic elements. Simultaneously, IBM engineers and IBM customers challenged the company to engage in computer innovation and production and they used...

  14. 76 FR 174 - International Business Machines (IBM), Global Sales Operations Organization, Sales and...

    Science.gov (United States)

    2011-01-03

    ... Employment and Training Administration International Business Machines (IBM), Global Sales Operations...; International Business Machines (IBM), Global Sales Operations Organization, Sales and Distribution Business..., applicable to workers of International Business Machines (IBM), Global Sales Operations Organization, Sales...

  15. 75 FR 60141 - International Business Machines (IBM), Global Technology Services Delivery Division, Including On...

    Science.gov (United States)

    2010-09-29

    ... Employment and Training Administration International Business Machines (IBM), Global Technology Services... of International Business Machines (IBM), Global Technology Services Delivery Division, Greenville... International Business Machines (IBM), Global Technology Services Delivery Division, including on-site leased...

  16. Establishing a communications link between two different, incompatible, personal computers: with practical examples and illustrations and program code.

    Science.gov (United States)

    Davidson, R W

    1985-01-01

    The increasing need to communicate to exchange data can be handled by personal microcomputers. The necessity for the transference of information stored in one type of personal computer to another type of personal computer is often encountered in the process of integrating multiple sources of information stored in different and incompatible computers in Medical Research and Practice. A practical example is demonstrated with two relatively inexpensive commonly used computers, the IBM PC jr. and the Apple IIe. The basic input/output (I/O) interface chip for serial communication for each computer are joined together using a Null connector and cable to form a communications link. Using BASIC (Beginner's All-purpose Symbolic Instruction Code) Computer Language and the Disk Operating System (DOS) the communications handshaking protocol and file transfer is established between the two computers. The BASIC programming languages used are Applesoft (Apple Personal Computer) and PC BASIC (IBM Personal computer).

  17. An Amphibious Ship-To-Shore Simulation for Use on an IBM PC (Personal Computer)

    Science.gov (United States)

    1984-09-01

    Test • Have/Serial # £§is Carrier 12£§ Number Carriers Pest Sched helo #1/#1 10 CH-46 2 R-1 Sck€d helo #1/#2 10 CH-4 6 2 R...is no reason at this point to discount the output of SHIPSHOR. C. SIHSITIVITY ANALISIS 1. General The purpose of sensitivity analysis

  18. Biomimicry 1: PC.

    Science.gov (United States)

    Cumberland, D C; Gunn, J; Malik, N; Holt, C M

    1998-01-01

    The surface properties of stents can be modified by coating them, for example with a polymer. Phosphorylcoline (PC) is the major component of the outer layer of the cell membrane. The haemo- and biocompatibility of a PC-containing polymer is thus based on biomimicry, and has been confirmed by several experiments showing much reduced thrombogenicity of PC-coated surfaces, and porcine coronary artery implants showing no sign of adverse effect. Clinical experience with the PC-coated BiodivYsio appears favourable. The PC coating can be tailored for take up and controlled elution of various drugs for stent-based local delivery, a property which is being actively explored.

  19. Uporaba orodja poslovne inteligence IBM Watson za predvidevanje prodaje

    OpenAIRE

    Stojić, Igor

    2016-01-01

    Diplomska naloga obravnava uporabo orodja IBM Watson in njegovo poslovno vrednost, ki jo ima v okviru oblikovanja napovedi prihodnje prodaje produktov. V teoretičnem delu podrobneje opredeljuje napovedovanje in smoter le-tega. V okviru empiričnega dela pa je bila izvedena primerjava uporabe ERP sistemov SAP in IBM Watson, pri čemer je bil dosledno prikazan postopek oblikovanja napovedi, tako s SAP kot tudi z IBM Watson, s slednjim pa tudi identificiran parameter, ki vpliva na prodajo nekateri...

  20. OPMILL - MICRO COMPUTER PROGRAMMING ENVIRONMENT FOR CNC MILLING MACHINES THREE AXIS EQUATION PLOTTING CAPABILITIES

    Science.gov (United States)

    Ray, R. B.

    1994-01-01

    OPMILL is a computer operating system for a Kearney and Trecker milling machine that provides a fast and easy way to program machine part manufacture with an IBM compatible PC. The program gives the machinist an "equation plotter" feature which plots any set of equations that define axis moves (up to three axes simultaneously) and converts those equations to a machine milling program that will move a cutter along a defined path. Other supported functions include: drill with peck, bolt circle, tap, mill arc, quarter circle, circle, circle 2 pass, frame, frame 2 pass, rotary frame, pocket, loop and repeat, and copy blocks. The system includes a tool manager that can handle up to 25 tools and automatically adjusts tool length for each tool. It will display all tool information and stop the milling machine at the appropriate time. Information for the program is entered via a series of menus and compiled to the Kearney and Trecker format. The program can then be loaded into the milling machine, the tool path graphically displayed, and tool change information or the program in Kearney and Trecker format viewed. The program has a complete file handling utility that allows the user to load the program into memory from the hard disk, save the program to the disk with comments, view directories, merge a program on the disk with one in memory, save a portion of a program in memory, and change directories. OPMILL was developed on an IBM PS/2 running DOS 3.3 with 1 MB of RAM. OPMILL was written for an IBM PC or compatible 8088 or 80286 machine connected via an RS-232 port to a Kearney and Trecker Data Mill 700/C Control milling machine. It requires a "D:" drive (fixed-disk or virtual), a browse or text display utility, and an EGA or better display. Users wishing to modify and recompile the source code will also need Turbo BASIC, Turbo C, and Crescent Software's QuickPak for Turbo BASIC. IBM PC and IBM PS/2 are registered trademarks of International Business Machines. Turbo

  1. Users guide for the ANL IBM SP1

    Energy Technology Data Exchange (ETDEWEB)

    Gropp, W.; Lusk, E.; Pieper, S.C.

    1994-10-01

    This guide presents the features of the IBM SP1 installed in the Mathematics and Computer Science Division at Argonne National Laboratory. The guide describes the available hardware and software, access policies, and hints for using the system productively.

  2. Training IBM Watson using Automatically Generated Question-Answer Pairs

    OpenAIRE

    Lee, Jangho; Kim, Gyuwan; Yoo, Jaeyoon; Jung, Changwoo; Kim, Minseok; Yoon, Sungroh

    2016-01-01

    IBM Watson is a cognitive computing system capable of question answering in natural languages. It is believed that IBM Watson can understand large corpora and answer relevant questions more effectively than any other question-answering system currently available. To unleash the full power of Watson, however, we need to train its instance with a large number of well-prepared question-answer pairs. Obviously, manually generating such pairs in a large quantity is prohibitively time consuming and...

  3. IBM Watson Analytics: Automating Visualization, Descriptive, and Predictive Statistics

    OpenAIRE

    Hoyt, Robert Eugene; Snider, Dallas; Thompson, Carla; Mantravadi, Sarita

    2016-01-01

    Background We live in an era of explosive data generation that will continue to grow and involve all industries. One of the results of this explosion is the need for newer and more efficient data analytics procedures. Traditionally, data analytics required a substantial background in statistics and computer science. In 2015, International Business Machines Corporation (IBM) released the IBM Watson Analytics (IBMWA) software that delivered advanced statistical procedures based on the Statistic...

  4. 39 CFR 501.16 - PC postage payment methodology.

    Science.gov (United States)

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false PC postage payment methodology. 501.16 Section 501.16 Postal Service UNITED STATES POSTAL SERVICE POSTAGE PROGRAMS AUTHORIZATION TO MANUFACTURE AND DISTRIBUTE POSTAGE EVIDENCING SYSTEMS § 501.16 PC postage payment methodology. (a) The PC Postage customer is...

  5. PC-based tele-audiometry.

    Science.gov (United States)

    Choi, Jong Min; Lee, Haet Bit; Park, Cheol Soo; Oh, Seung Ha; Park, Kwang Suk

    2007-10-01

    A personal computer (PC)-based audiometer was developed for interactive remote audiometry. This paper describes a tele-audiometric system and evaluates the performance of the device when compared with conventional face-to-face audiometry. The tele-audiometric system is fully PC-based. A sound card featuring a high-quality digital-to-analog converter is used as a pure-tone generator. The audiometric programs were developed based on Microsoft Windows in order to maximize usability. Audiologists and their subjects can use the tele-audiometry system as one would utilize any PC application. A calibration procedure has been applied for the standardization of sound levels in the remote system. The performance of this system was evaluated by comparing PC-based audiometry with the conventional clinical audiometry system for 37 subjects. Also, performance of the PC-based system was evaluated during use at a remote site. The PC-based audiometry system estimated the audiometric threshold with an error of less than 2.3 dBSPL. Only 10.7% of the results exhibited an error greater than 5 dBSPL during use at a remote site. The PC-based tele-audiomerty showed acceptable results for use at a remote site. This PC-based system can be used effectively and easily in many locations that have Internet access but no local audiologists.

  6. Can IBMs tell us why most larvae die in the sea? Model sensitivities and scenarios reveal research needs

    Science.gov (United States)

    Peck, Myron A.; Hufnagl, Marc

    2012-05-01

    Biophysical individual-based models (IBMs) are the only tools that can provide estimates of spatial and temporal changes in mortality rates of marine fish early life stages as well as the various processes that contribute to those changes. Given the increasing use of these models, one must ask the question: How much faith can we have in their estimates? We briefly review mortality processes acting on marine fish early life stages and how IBMs have been used to estimate those processes. Next, we provide a summary of the sensitivity analyses and scenario results conducted in 50 studies that provided estimates of: 1) advection-based losses from drift modeling, 2) mortality due to starvation from foraging and growth modeling, and/or 3) modeled mortality due to predators. We illustrate how IBM estimates of larval distribution and survival can be sensitive to assumptions regarding the magnitude and timing of mortality by performing drift model simulations for Atlantic herring ( Clupea harengus) larvae in the North Sea. Despite the growing number of studies applying IBMs, less than 25% reviewed here included formal sensitivity analyses of parameters. Our literature review indicated a need for biological research on 1) larval swimming behavior including cues for movements, 2) foraging parameters such as larval visual field estimates, and 3) parameters associated with growth physiology including assimilation efficiency and energy losses due to active metabolism. Ontogenetic changes in those factors are particularly relevant to examine for modeling activities. Methods also need to be developed for depicting predator encounter in a dynamic way (e.g., based upon predator-prey overlap). High priority should be given to developing (and funding) research programs that not only construct and apply IBMs but also that measure the aspects of larval behavior and physiology as well as aspects of the larval environment needed to parameterize them. Coupling these research activities will

  7. Leo II PC

    Data.gov (United States)

    Kansas Data Access and Support Center — LEO II is a second-generation software system developed for use on the PC, which is designed to convert location references accurately between legal descriptions and...

  8. The web server of IBM's Bioinformatics and Pattern Discovery group.

    Science.gov (United States)

    Huynh, Tien; Rigoutsos, Isidore; Parida, Laxmi; Platt, Daniel; Shibuya, Tetsuo

    2003-07-01

    We herein present and discuss the services and content which are available on the web server of IBM's Bioinformatics and Pattern Discovery group. The server is operational around the clock and provides access to a variety of methods that have been published by the group's members and collaborators. The available tools correspond to applications ranging from the discovery of patterns in streams of events and the computation of multiple sequence alignments, to the discovery of genes in nucleic acid sequences and the interactive annotation of amino acid sequences. Additionally, annotations for more than 70 archaeal, bacterial, eukaryotic and viral genomes are available on-line and can be searched interactively. The tools and code bundles can be accessed beginning at http://cbcsrv.watson.ibm.com/Tspd.html whereas the genomics annotations are available at http://cbcsrv.watson.ibm.com/Annotations/.

  9. IBM SP high-performance networking with a GRF.

    Energy Technology Data Exchange (ETDEWEB)

    Navarro, J.P.

    1999-05-27

    Increasing use of highly distributed applications, demand for faster data exchange, and highly parallel applications can push the limits of conventional external networking for IBM SP sites. In technical computing applications we have observed a growing use of a pipeline of hosts and networks collaborating to collect, process, and visualize large amounts of realtime data. The GRF, a high-performance IP switch from Ascend and IBM, is the first backbone network switch to offer a media card that can directly connect to an SP Switch. This enables switch attached hosts in an SP complex to communicate at near SP Switch speeds with other GRF attached hosts and networks.

  10. IBM WebSphere Application Server 80 Administration Guide

    CERN Document Server

    Robinson, Steve

    2011-01-01

    IBM WebSphere Application Server 8.0 Administration Guide is a highly practical, example-driven tutorial. You will be introduced to WebSphere Application Server 8.0, and guided through configuration, deployment, and tuning for optimum performance. If you are an administrator who wants to get up and running with IBM WebSphere Application Server 8.0, then this book is not to be missed. Experience with WebSphere and Java would be an advantage, but is not essential.

  11. Generalized Information Architecture for Managing Requirements in IBM?s Rational DOORS(r) Application.

    Energy Technology Data Exchange (ETDEWEB)

    Aragon, Kathryn M.; Eaton, Shelley M.; McCornack, Marjorie Turner; Shannon, Sharon A.

    2014-12-01

    When a requirements engineering effort fails to meet expectations, often times the requirements management tool is blamed. Working with numerous project teams at Sandia National Laboratories over the last fifteen years has shown us that the tool is rarely the culprit; usually it is the lack of a viable information architecture with well- designed processes to support requirements engineering. This document illustrates design concepts with rationale, as well as a proven information architecture to structure and manage information in support of requirements engineering activities for any size or type of project. This generalized information architecture is specific to IBM's Rational DOORS (Dynamic Object Oriented Requirements System) software application, which is the requirements management tool in Sandia's CEE (Common Engineering Environment). This generalized information architecture can be used as presented or as a foundation for designing a tailored information architecture for project-specific needs. It may also be tailored for another software tool. Version 1.0 4 November 201

  12. SHOOT GROWTH1 maintains Arabidopsis epigenomes by regulating IBM1.

    Directory of Open Access Journals (Sweden)

    Vincent Coustham

    Full Text Available Maintaining correct DNA and histone methylation patterns is essential for the development of all eukaryotes. In Arabidopsis, we identified SHOOT GROWTH1 (SG1, a novel protein involved in the control of gene methylation. SG1 contains both a Bromo-Adjacent Homology (BAH domain found in several chromatin regulators and an RNA-Recognition Motif (RRM. The sg1 mutations are associated with drastic pleiotropic phenotypes. The mutants degenerate after few generations and are similar to mutants of the histone demethylase INCREASE IN BONSAI METHYLATION1 (IBM1. A methylome analysis of sg1 mutants revealed a large number of gene bodies hypermethylated in the cytosine CHG context, associated with an increase in di-methylation of lysine 9 on histone H3 tail (H3K9me2, an epigenetic mark normally found in silenced transposons. The sg1 phenotype is suppressed by mutations in genes encoding the DNA methyltransferase CHROMOMETHYLASE3 (CMT3 or the histone methyltransferase KRYPTONITE (KYP, indicating that SG1 functions antagonistically to CMT3 or KYP. We further show that the IBM1 transcript is not correctly processed in sg1, and that the functional IBM1 transcript complements sg1. Altogether, our results suggest a function for SG1 in the maintenance of genome integrity by regulating IBM1.

  13. SHOOT GROWTH1 maintains Arabidopsis epigenomes by regulating IBM1.

    Science.gov (United States)

    Coustham, Vincent; Vlad, Daniela; Deremetz, Aurélie; Gy, Isabelle; Cubillos, Francisco A; Kerdaffrec, Envel; Loudet, Olivier; Bouché, Nicolas

    2014-01-01

    Maintaining correct DNA and histone methylation patterns is essential for the development of all eukaryotes. In Arabidopsis, we identified SHOOT GROWTH1 (SG1), a novel protein involved in the control of gene methylation. SG1 contains both a Bromo-Adjacent Homology (BAH) domain found in several chromatin regulators and an RNA-Recognition Motif (RRM). The sg1 mutations are associated with drastic pleiotropic phenotypes. The mutants degenerate after few generations and are similar to mutants of the histone demethylase INCREASE IN BONSAI METHYLATION1 (IBM1). A methylome analysis of sg1 mutants revealed a large number of gene bodies hypermethylated in the cytosine CHG context, associated with an increase in di-methylation of lysine 9 on histone H3 tail (H3K9me2), an epigenetic mark normally found in silenced transposons. The sg1 phenotype is suppressed by mutations in genes encoding the DNA methyltransferase CHROMOMETHYLASE3 (CMT3) or the histone methyltransferase KRYPTONITE (KYP), indicating that SG1 functions antagonistically to CMT3 or KYP. We further show that the IBM1 transcript is not correctly processed in sg1, and that the functional IBM1 transcript complements sg1. Altogether, our results suggest a function for SG1 in the maintenance of genome integrity by regulating IBM1.

  14. Elementary? Question Answering, IBM's Watson, and the Jeopardy ...

    Indian Academy of Sciences (India)

    IAS Admin

    In this article, we start with John McCarthy's definition of. Artificial Intelligence and describe select approaches to its sub-areas: natural language processing and question answer- ing. We then outline the challenge that IBM Research under- took to build Watson, a question-answering computer system that would compete at ...

  15. Software Process Improvement Journey: IBM Australia Application Management Services

    Science.gov (United States)

    2005-03-01

    See Section 5.1.2) - Client Relationship Management ( CRM ) processes-specifically, Solution Design and Solution Delivery - Worldwide Project Management ...plex systems life-cycle management , rapid solutions development, custom development, package selection and implementation, maintenance, minor...CarnegieMellon ___ Software Engineering Institute Software Process Improvement Journey: IBM Australia Application Management Services Robyn Nichols

  16. Hazardous Waste Cleanup: IBM Corporation in Poughkeepsie, New York

    Science.gov (United States)

    This site covers approximately 423 acres, two-thirds of which is occupied by a manufacturing complex with more than 50 buildings. The land use in the area is a mix of industrial, commercial and residential. IBM is located approximately six miles south of t

  17. Bus and Tag Terminators for IBM system/360

    CERN Multimedia

    Control units were connected to the channels with "Bus and Tag" cable pairs. The bus cables carried the address and data information and the tag cables identified what data was on the bus. There were three general types of bus-and-tag cables produced by IBM.

  18. Elementary? Question Answering, IBM's Watson, and the Jeopardy ...

    Indian Academy of Sciences (India)

    http://www.ias.ac.in/article/fulltext/reso/019/03/0222-0241. Keywords. John McCarthy; artificial intelligence; natural language processing; question answering system; IBM; DeepQA; Watson; Jeopardy!; quiz show. Author Affiliations. Raman Chandrasekar1. ProQuest 501 North 34th Street Suite 300, Seattle, WA 98103, USA ...

  19. Excimer laser ablation of polyimide: a 14-year IBM perspective

    Science.gov (United States)

    Brannon, James H.; Wassick, Thomas A.

    1997-05-01

    IBM introduced the first commercial high-end mainframe computer system incorporating laser ablation technology in 1991. This milestone was the culmination of nearly a decade of scientific, engineering, and manufacturing effort. Extensive research and development on 308 nm laser ablation of polyimide lead to the first IBM prototype ablation tool in 1987 for the production of via-holes in thin film packaging structures. This prototype, similar to step and repeat photolithography systems, evolved into full-scale manufacturing tools which utilize sophisticated beam shaping, beam homogenizing, and projection optics. But the maturity of this technology belies the fact that the scientific understanding of the laser ablation process is still far from complete. This paper briefly reviews the engineering and scientific accomplishments, both within and external to IBM, that lead to the commercial utilization of the laser ablation process. Current technical tissues are discussed, in addition to alternative IBM applications of polyimide ablation. The paper concludes by discussing the relative merits of excimer vs. solid-state lasers, and how each may impact future manufacturing technology.

  20. IBM to help CERN build massive data grid to understand origins of the Universe

    CERN Multimedia

    2003-01-01

    "IBM and the European Organization for Nuclear Research (CERN) have announced that IBM is joining the CERN openlab for DataGrid applications to collaborate in creating a massive data-management system built on grid computing" (1 page).

  1. 76 FR 21033 - International Business Machines (IBM), Sales and Distribution Business Unit, Global Sales...

    Science.gov (United States)

    2011-04-14

    ... workers of International Business Machines (IBM), Sales and Distribution Business Unit, Global Sales... Employment and Training Administration International Business Machines (IBM), Sales and Distribution Business Unit, Global Sales Solution Department, Off-Site Teleworker in Centerport, New York; Notice of...

  2. 76 FR 54800 - International Business Machines (IBM), Software Group Business Unit, Quality Assurance Group, San...

    Science.gov (United States)

    2011-09-02

    ... Business Machines (IBM), Software Group Business Unit, Quality Assurance Group, San Jose, California... Employment and Training Administration International Business Machines (IBM), Software Group Business Unit, Quality Assurance Group, San Jose, California; Notice of Negative Determination on Reconsideration On...

  3. Building the perfect PC

    CERN Document Server

    Thompson, Robert Bruce

    2006-01-01

    This popular Build-It-Yourself (BIY) PC book covers everything you want to know about building your own system: Planning and picking out the right components, step-by-step instructions for assembling your perfect PC, and an insightful discussion of why you'd want to do it in the first place. Most big brand computers from HP, Dell and others use lower-quality components so they can meet their aggressive pricing targets. But component manufacturers also make high-quality parts that you can either purchase directly, or obtain through distributors and resellers. Consumers and corporations

  4. IBM Programming Support Packages for NSW (National Software Works)

    Science.gov (United States)

    1980-11-15

    TSO userid under which this session is logged on. * JONLINE/NOJONLIN enables or disables the " online " destination for log data. If this destination is...A type of "CALL" will never be returned from PCEXAM for an agressive introverted process. For a passive introverted process, only the first message...and completed, so it does not remain pending. A type of "LOG" will never be returned from PCEXAM for an agressive introverted process. For a passive

  5. 76 FR 32231 - International Business Machines (IBM), Sales and Distribution Business Unit, Global Sales...

    Science.gov (United States)

    2011-06-03

    ... Business Machines (IBM), Sales and Distribution Business Unit, Global Sales Solution Department, off-site... and location is International Business Machines (IBM), Sales and Distribution Business Unit, Global... totally or partially separated from IBM, Sales and Distribution Business Unit, Global Sales Solution...

  6. 76 FR 5832 - International Business Machines (IBM), Software Group Business Unit, Optim Data Studio Tools QA...

    Science.gov (United States)

    2011-02-02

    ... Employment and Training Administration International Business Machines (IBM), Software Group Business Unit... at International Business Machines (IBM), Software Group Business Unit, Optim Data Studio Tools QA... IBM employees working on the relevant product within the Data Studio Tools QA on a part-time basis and...

  7. Beware the PC Police.

    Science.gov (United States)

    Cheney, Lynne V.

    1992-01-01

    Decries the prevalence of "racism,""sexual harassment," and "speciesism" labels applied to supposed violators of "political correctness" (PC). When freedom of speech on college campuses is held hostage to political correctness, K-12 education is bound to be affected. This new brand of McCarthyism cheapens…

  8. IbM Pengendalian Hama Terpadu (PHT pada Tanaman Sayuran di Kota Tomohon

    Directory of Open Access Journals (Sweden)

    Christina L. Salaki

    2017-03-01

    Full Text Available An integrated pest control on vegetables crops in the fields,  is one of the control method to suppress the insect pest population , therefore farmer do not depend on the chemical controls that have negative effect both on the environment and human as well as animal.  The science and technology program for communities [IbM] aim to get a package of integrated pest control technology that is enviromentally friendly and it is derived from Indonesian microbial resources to support sustainable agriculture system .  To achieve  the goal, the program  implemented  through counseling, plot demonstration and field work.  These activities provided motivation  to farmers to be able to use biological agents combined with culture control to suppress population of insect pest and vegetables through the extension activities and the plot  demonstrations.  The IbM activity gave benefit to farmers by transfer knowledge through extension methods on how to get and use biopesticides with its theory and it can be directly practiced by farmers in the form of a plot demonstrations.

  9. [Neutrophil chemiluminescence using the Luminometer-1251 device and the Lumograf program].

    Science.gov (United States)

    Borunov, E V; Shchepetkin, I A; Cherdyntsev, E S; Cherdyntseva, N V

    1993-01-01

    Luminometer-1251 device in complex with the IBM-PC type computer was used to record the neutrophilic chemiluminescence response. Luminol-dependent chemiluminescent response of human neutrophils treated with phorbol-12-myristate-13-acetate in concentrations from 0.5 to 100 nM was examined over a 5 h incubation period. The results were computer-processed using an authors' program Lumograf. The suggested method may be used to record and process the data of long-coursing processes of chemiluminescence in a large series of samples.

  10. Instructions for using SOW Pk program

    Energy Technology Data Exchange (ETDEWEB)

    Magnoli, D.E.

    1989-06-01

    PKSOW is a Fortran program developed at Lawrence Livermore National Laboratory to calculate the probability of kill (P{sub k}) of a submarine-launched ASW nuclear standoff weapon. The calculation can be done for a broad spectrum of conditions: the user specifies weapon characteristics (yield, depth of burst), target localization and course and speed errors, target evasion tactics, target damage specifications, and safe standoff parameters. Output from the program includes a table of Pk at various standoff ranges for each of several yields. This version of PKSOW has been adapted to run on the IBM PC using MS/DOS. The output from the program may be used with MS CHART to produce plots of Pk vs standoff range.

  11. IBM techexplorer and MathML: Interactive Multimodal Scientific Documents

    Science.gov (United States)

    Diaz, Angel

    2001-06-01

    The World Wide Web provides a standard publishing platform for disseminating scientific and technical articles, books, journals, courseware, or even homework on the internet; however, the transition from paper to web-based interactive content has brought new opportunities for creating interactive content. Students, scientists, and engineers are now faced with the task of rendering the 2D presentational structure of mathematics, harnessing the wealth of scientific and technical software, and creating truly accessible scientific portals across international boundaries and markets. The recent emergence of World Wide Web Consortium (W3C) standards such as the Mathematical Markup Language (MathML), Language (XSL), and Aural CSS (ACSS) provide a foundation whereby mathematics can be displayed, enlivened, computed, and audio formatted. With interoperability ensured by standards, software applications can be easily brought together to create extensible and interactive scientific content. In this presentation we will provide an overview of the IBM techexplorer Hypermedia Browser, a web browser plug-in and ActiveX control aimed at bringing interactive mathematics to the masses across platforms and applications. We will demonstrate "live" mathematics where documents that contain MathML expressions can be edited and computed right inside your favorite web browser. This demonstration will be generalized as we show how MathML can be used to enliven even PowerPoint presentations. Finally, we will close the loop by demonstrating a novel approach to spoken mathematics based on MathML, DOM, XSL, ACSS, techexplorer, and IBM ViaVoice. By making use of techexplorer as the glue that binds the rendered content to the web browser, the back-end computation software, the Java applets that augment the exposition, and voice-rendering systems such as ViaVoice, authors can indeed create truly extensible and interactive scientific content. For more information see: [http://www.software.ibm

  12. IBM DB2 97 Advanced Application Developer Cookbook

    CERN Document Server

    Saraswatipura, Mohankumar

    2012-01-01

    This cookbook has recipes written in a simple, easy to understand format with lots of screenshots and insightful tips and hints. If you are an IBM DB2 application developer who would like to exploit advanced features provided by DB2 to design and implement high quality applications, then this book is for you. This book assumes you have a basic understanding of the DB2 application development.

  13. Installation and implementation of PC COSYMA; PC COSYMAn kaeyttoeoenotto ja soveltaminen

    Energy Technology Data Exchange (ETDEWEB)

    Rossi, J. [VTT Energy, Espoo (Finland). Nuclear Energy

    1995-12-01

    COSYMA is a probabilistic reactor accident consequence assessment model developed in the 1980`s by the research institutes of the EC countries, primarily by NRPB and KfK. In 1993 a simplified version of the program was released to be implemented on a PC. In the study the PC COSYMA program was applied to calculate as the end points nuclide concentrations, doses received, numbers of health effects, areas affected by countermeasures and other results related to countermeasure strategies. Some results are compared with the results obtained by the ARANO program developed by VTT Energy (Technical Research Centre of Finland) to quarantee proper interpretation of the application. (15 refs.).

  14. Correlation of muscle biopsy, clinical course, and outcome in PM and sporadic IBM.

    Science.gov (United States)

    Chahin, Nizar; Engel, Andrew G

    2008-02-05

    To correlate muscle biopsy findings with prebiopsy and postbiopsy clinical course and response to therapy in polymyositis (PM) and sporadic inclusion body myositis (IBM). Existence of pure PM has recently been questioned; subsequently, the definition and criteria for diagnosing PM were debated. Patient records, follow-up information, and muscle biopsies were analyzed in 107 patients whose biopsies were initially read as PM and IBM. The patients fell into three groups by combined biopsy and clinical criteria: PM, 27 patients; IBM, 64 patients; PM/IBM, 16 patients with biopsy diagnosis of PM but clinical features of IBM. For the three groups, the respective mean periods from disease onset to end of follow-up were 5.9, 8.5, and 9.6 years. Another autoimmune disease was present in 4 of 27 PM, 8 of 64 IBM, and 1 of 16 PM/IBM cases. An autoimmune serologic marker occurred in one-third of each group. Nineteen PM patients had no associated autoimmune disease or marker. Nonnecrotic fiber invasion by mononuclear cells appeared in all IBM, 17 of 27 PM, and 13 of 16 PM/IBM patients. The density of both invaded fibers and cytochrome-c oxidase-negative fibers was higher in IBM and PM/IBM than in PM. Immunotherapy improved 22 of 27 PM patients but had only transient beneficial effects in 2 of 32 IBM and 1 of 14 PM/IBM patients. 1) Sixteen of 43 patients (37%) with biopsy features of polymyositis (PM) had clinical features of inclusion body myositis (IBM). 2) Absence of canonical biopsy features of IBM from clinically affected muscles of IBM patients challenges biopsy criteria for IBM, or the IBM markers appear late in some patients, or their distribution in muscle is patchy and restricted compared with that of the inflammatory exudate. 3) The muscle biopsy is a reliable instrument in the diagnosis of PM and IBM in close to 85% of the patients. Errors of diagnosis in the remaining 15% can be avoided or reduced by combined evaluation of the clinical and pathologic findings.

  15. Bill Lang's contributions to acoustics at International Business Machines Corporation (IBM), signal processing, international standards, and professionalism in noise control engineering

    Science.gov (United States)

    Maling, George C.

    2005-09-01

    Bill Lang joined IBM in the late 1950s with a mandate from Thomas Watson Jr. himself to establish an acoustics program at IBM. Bill created the facilities in Poughkeepsie, developed the local program, and was the leader in having other IBM locations with development and manufacturing responsibilities construct facilities and hire staff under the Interdivisional Liaison Program. He also directed IBMs acoustics technology program. In the mid-1960s, he led an IEEE standards group in Audio and Electroacoustics, and, with the help of James Cooley, Peter Welch, and others, introduced the fast Fourier transform to the acoustics community. He was the convenor of ISO TC 43 SC1 WG6 that began writing the 3740 series of standards in the 1970s. It was his suggestion to promote professionalism in noise control engineering, and, through meetings with Leo Beranek and others, led the founding of INCE/USA in 1971. He was also a leader of the team that founded International INCE in 1974, and he served as president from 1988 until 1999.

  16. A PC Controlled Filter

    Directory of Open Access Journals (Sweden)

    M. Van Looy

    1998-12-01

    Full Text Available In this paper we present a switched capacitor filter design using the SC22324 1C, which is fitted with an E2PROM. It contains four digitally programmable switched-capacitor filter sections, in order to obtain different responses. The SC22324 also contains the on-chip RAM. We'd like to explain, how could the on-chip RAM controlled via a PC. In this way the chip may be used afterwards with a menu where the user may select the wanted parameters.

  17. Approximate Quantum Adders with Genetic Algorithms: An IBM Quantum Experience

    Directory of Open Access Journals (Sweden)

    Li Rui

    2017-07-01

    Full Text Available It has been proven that quantum adders are forbidden by the laws of quantum mechanics. We analyze theoretical proposals for the implementation of approximate quantum adders and optimize them by means of genetic algorithms, improving previous protocols in terms of efficiency and fidelity. Furthermore, we experimentally realize a suitable approximate quantum adder with the cloud quantum computing facilities provided by IBM Quantum Experience. The development of approximate quantum adders enhances the toolbox of quantum information protocols, paving the way for novel applications in quantum technologies.

  18. Driving the Power of AIX Performance Tuning on IBM Power

    CERN Document Server

    Milberg, Ken

    2009-01-01

    A concise reference for IT professionals, this book goes beyond the rules and contains the best practices and strategies for solid tuning methodology. Tips based on years of experience from an AIX tuning master show specific steps for monitoring and tuning CPU, virtual memory, disk I/O, and network components. Also offering techniques for tuning Oracle and Linux structures that run on an IBM power system-as well as for the new AIX 6.1-this manual discusses what tools are available, how to best use them to collect historical data, and when to analyze trends and results. The only comprehensive,

  19. Handbook of univariate and multivariate data analysis with IBM SPSS

    CERN Document Server

    Ho, Robert

    2013-01-01

    Using the same accessible, hands-on approach as its best-selling predecessor, the Handbook of Univariate and Multivariate Data Analysis with IBM SPSS, Second Edition explains how to apply statistical tests to experimental findings, identify the assumptions underlying the tests, and interpret the findings. This second edition now covers more topics and has been updated with the SPSS statistical package for Windows.New to the Second EditionThree new chapters on multiple discriminant analysis, logistic regression, and canonical correlationNew section on how to deal with missing dataCoverage of te

  20. Demonstration of entanglement assisted invariance on IBM's Quantum Experience

    Science.gov (United States)

    Deffner, Sebastian

    Quantum entanglement is among the most fundamental, yet from classical intuition also most surprising properties of the fully quantum nature of physical reality. We report several experiments performed on IBM's Quantum Experience demonstrating envariance - entanglement assisted invariance. Envariance is a recently discovered symmetry of composite quantum systems, which is at the foundational origin of physics and a purely quantum phenomenon. These very easily reproducible and freely accessible experiments on Quantum Experience provide simple tools to study the properties of envariance, and we illustrate this for several cases with ``quantum universes'' consisting of up to five qubits.

  1. Approximate Quantum Adders with Genetic Algorithms: An IBM Quantum Experience

    Science.gov (United States)

    Li, Rui; Alvarez-Rodriguez, Unai; Lamata, Lucas; Solano, Enrique

    2017-07-01

    It has been proven that quantum adders are forbidden by the laws of quantum mechanics. We analyze theoretical proposals for the implementation of approximate quantum adders and optimize them by means of genetic algorithms, improving previous protocols in terms of efficiency and fidelity. Furthermore, we experimentally realize a suitable approximate quantum adder with the cloud quantum computing facilities provided by IBM Quantum Experience. The development of approximate quantum adders enhances the toolbox of quantum information protocols, paving the way for novel applications in quantum technologies.

  2. A dysphagia study in patients with sporadic inclusion body myositis (s-IBM).

    Science.gov (United States)

    Murata, Ken-Ya; Kouda, Ken; Tajima, Fumihiro; Kondo, Tomoyoshi

    2012-08-01

    The nature of the swallowing impairment in patients with sporadic inclusion body myositis (s-IBM) has not been well characterized. In this study, we examined ten consecutive s-IBM patients using videofluoroscopy (VF) and computed pharyngoesophageal manometry (CPM). The patients were divided into two groups: patients with complaint and without complaint of dysphagia. VF results indicated pharyngeal muscle propulsion (PP) at the hypopharyngeal and upper esophagus sphincter (UES) in all s-IBM patients. Patients without complaint of dysphagia showed a mild degree of PP, whereas a severe form of PP was observed in patients with complaint of dysphagia. CPM revealed that negative pressure during UES opening was not observed in the s-IBM patients with complaint of dysphagia. Incomplete opening and PP at the UES were observed in all s-IBM patients. These results indicate that the dysphagic processes occur subclinically in s-IBM patients who may not report swallowing impairments.

  3. Software Defined Radio Datalink Implementation Using PC-Type Computers

    National Research Council Canada - National Science Library

    Zafeiropoulos, Georgios

    2003-01-01

    The objective of this thesis was to examine the feasibility of implementation and the performance of a Software Defined Radio datalink, using a common PC type host computer and a high level programming language...

  4. International Business Machines (IBM) Corporation Interim Agreement EPA Case No. 08-0113-00

    Science.gov (United States)

    On March 27, 2008, the United States Environmental Protection Agency (EPA), suspended International Business Machines (IBM) from receiving Federal Contracts, approved subcontracts, assistance, loans and other benefits.

  5. Effect of system workload on operating system reliability - A study on IBM 3081

    Science.gov (United States)

    Iyer, R. K.; Rossetti, D. J.

    1985-01-01

    This paper presents an analysis of operating system failures on an IBM 3081 running VM/SP. Three broad categories of software failures are found: error handling, program control or logic, and hardware related; it is found that more than 25 percent of software failures occur in the hardware/software interface. Measurements show that results on software reliability cannot be considered representative unless the system workload is taken into account. The overall CPU execution rate, although measured to be close to 100 percent most of the time, is not found to correlate strongly with the occurrence of failures. Possible reasons for the observed workload failure dependency, based on detailed investigations of the failure data, are discussed.

  6. Centro de cálculo IBM - Francfort (Alemania Federal

    Directory of Open Access Journals (Sweden)

    Apel, Beckert, Becker, Arquitectos

    1972-03-01

    Full Text Available This centre comprises a tall building, of approximately square cross section, and a 10 m high rectangular block. The first one houses the offices, and the second contains an IBM computer and accessories. The structure is of reinforced concrete for the vertical members, and ribbed flooring slabs for the horizontal ones. The external enclosing medium consists of precast concrete elements, and large glazed surfaces. The are features of ornamental significance, such as the indoor helicoidal stairs of unfaced concrete, and the slab covered square, with its garden and artificial lake areas. Parking space is provided in the basements.El complejo se compone de: — un rascacielos con planta sensiblemente cuadrada y 38 m de altura, y — un bloque rectangular, más bajo, de 9,90 m de alto. El primero alberga las oficinas, y el segundo se destina a cubrir todas las exigencias que se derivan del funcionamiento de un ordenador IBM. Su estructura, a base de núcleos verticales de hormigón armado, forjados nervados y cerramientos compuestos de piezas de hormigón, prefabricadas, con grandes zonas acristaladas. Hay motivos ornamentales, como la escalera helicoidal interior, de hormigón visto, y la plaza enlosada, con estanques y jardineras. Aparcamiento en el sótano.

  7. Edificio "IBM avenida de América" Madrid

    Directory of Open Access Journals (Sweden)

    Gayarre, Salvador

    1991-06-01

    Full Text Available The very actual subject of the "smart builgings", as those that incorporate Information technologie elements to be able for the avanced services performances, is the theme of this work about the IBM building in Madrid, that has been thought to help the persons that work behind it or that have any relations hip with the enterprise. The main architectural characteristics systems and services are described, including perspectives and drawings to make easier the comprehension of the proyect.

    El tema muy actual de los "edificios inteligentes", es decir, los que incorporan elementos de las Tecnologías de la Información que los capaciten para la prestación de servicios avanzados, es tratado en el presente artículo referido a un magnífico edificio madrileño, concebido para ayudar al individuo, tanto a las personas que trabajan en él como a aquellas que mantienen relación con IBM España. Se sintetizan en el artículo las características arquitectónicas del edificio y se describen los sistemas y servicios más importantes, incluyéndose las plantas y perspectivas que permiten al lector tener una idea del conjunto.

  8. Repairing and Upgrading Your PC

    CERN Document Server

    Thompson, Robert

    2009-01-01

    Repairing and Upgrading Your PC delivers start-to-finish instructions, simple enough for even the most inexperienced PC owner, for troubleshooting, repairing, and upgrading your computer. Written by hardware experts Robert Bruce Thompson and Barbara Fritchman Thompson, this book covers it all: how to troubleshoot a troublesome PC, how to identify which components make sense for an upgrade, and how to tear it all down and put it back together. This book shows how to repair and upgrade all of your PC's essential components.

  9. 76 FR 1990 - Airworthiness Directives; Pilatus Aircraft Ltd. Models PC-6, PC-6-H1, PC-6-H2, PC-6/350, PC-6/350...

    Science.gov (United States)

    2011-01-12

    ... PC- 6 Aircraft Maintenance Manual (AMM) Chapter 5 limitations which have included the same repetitive... inspections, in the latest revision of the PC-6 AMM, the replacement procedures for the fittings were included... PC- 6 Aircraft Maintenance Manual (AMM) Chapter 5 limitations which have included the same repetitive...

  10. 75 FR 62005 - Airworthiness Directives; Pilatus Aircraft Ltd. Models PC-6, PC-6-H1, PC-6-H2, PC-6/350, PC-6/350...

    Science.gov (United States)

    2010-10-07

    ... PC- 6 Aircraft Maintenance Manual (AMM) Chapter 5 limitations which have included the same repetitive... inspections, in the latest revision of the PC-6 AMM, the replacement procedures for the fittings were included... PC- 6 Aircraft Maintenance Manual (AMM) Chapter 5 limitations which have included the same repetitive...

  11. Optimizing the performance of streaming numerical kernels on the IBM Blue Gene/P PowerPC 450 processor

    KAUST Repository

    Malas, Tareq Majed Yasin

    2012-05-21

    Several emerging petascale architectures use energy-efficient processors with vectorized computational units and in-order thread processing. On these architectures the sustained performance of streaming numerical kernels, ubiquitous in the solution of partial differential equations, represents a challenge despite the regularity of memory access. Sophisticated optimization techniques are required to fully utilize the CPU. We propose a new method for constructing streaming numerical kernels using a high-level assembly synthesis and optimization framework. We describe an implementation of this method in Python targeting the IBM® Blue Gene®/P supercomputer\\'s PowerPC® 450 core. This paper details the high-level design, construction, simulation, verification, and analysis of these kernels utilizing a subset of the CPU\\'s instruction set. We demonstrate the effectiveness of our approach by implementing several three-dimensional stencil kernels over a variety of cached memory scenarios and analyzing the mechanically scheduled variants, including a 27-point stencil achieving a 1.7× speedup over the best previously published results. © The Author(s) 2012.

  12. Scientific Programming in Fortran

    Directory of Open Access Journals (Sweden)

    W. Van Snyder

    2007-01-01

    Full Text Available The Fortran programming language was designed by John Backus and his colleagues at IBM to reduce the cost of programming scientific applications. IBM delivered the first compiler for its model 704 in 1957. IBM's competitors soon offered incompatible versions. ANSI (ASA at the time developed a standard, largely based on IBM's Fortran IV in 1966. Revisions of the standard were produced in 1977, 1990, 1995 and 2003. Development of a revision, scheduled for 2008, is under way. Unlike most other programming languages, Fortran is periodically revised to keep pace with developments in language and processor design, while revisions largely preserve compatibility with previous versions. Throughout, the focus on scientific programming, and especially on efficient generated programs, has been maintained.

  13. Investigasi Serangan Malware Njrat Pada PC

    Directory of Open Access Journals (Sweden)

    Devi Rizky Septiani

    2016-12-01

    Full Text Available Malware merupakan salah satu bentuk dari kejahatan komputer yang terjadi pada sebuah sistem jaringan komputer, malware Njrat termasuk jenis Trojan horse. Trojan adalah salah satu jenis malware yang ikut berkembang di dalamnya, yang memungkinkan attacker masuk ke dalam sistem tanpa diketahui oleh pemilik. Penggunaan trojan saat ini lebih ke arah kejahatan dunia maya (cyber crime, salah satu dari malware yang sangat berbahaya karena besarnya dampak kerugian yang ditimbulkan, mulai dari pencurian data penting sampai mengubah hak akses pada PC korban. Sasaran terbanyak penybaran trojan adalah pengguna sistem operasi windows. Penyebaran trojan ini dilakukan dengan metode social engineering, yaitu teknik yang menggunakan kelemahan manusia, sehingga user tanpa curiga langsung mengeksekusi sebuah program yang tidak dikenal.  Aktivitas malware berkaitan erat dengan  performa PC dan juga aktifitas network pada system computer. Penelitian ini bertujuan untuk mengetahui cara kerja malware Njrat dan melakukan investigasi terhadap performa pada system computer. Metodologi yang digunakan dynamic analysis dengan melakukan analisa malware pada suatu sistem dan melihat aktivitas atau proses yang diaktifkan oleh malware tersebut. Dampak perubahan yang terjadi pada PC Target terlihat pada performa masing-masing PC yang telah disisipkan malware. Kata kunci            Malware, Njrat, System computer

  14. 78 FR 35321 - Solicitation for a Cooperative Agreement-IBM Instructional Guide and Assessment Tool Development

    Science.gov (United States)

    2013-06-12

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF JUSTICE National Institute of Corrections Solicitation for a Cooperative Agreement--IBM Instructional Guide and... reference the project by the ``NIC Opportunity Number'' (13JD04) and title in this announcement, ``IBM...

  15. Pengembangan Sistem Informasi Geografis Berbasis Node.JS untuk Pemetaan Mesin dan Tracking Engineer dengan Pemanfaatan Geolocation pada PT IBM Indonesia

    Directory of Open Access Journals (Sweden)

    RACHMAT FAJRIN

    2017-09-01

    Full Text Available PT IBM memiliki banyak klien di Indonesia, ini membuat persebaran produk (dalam hal ini mesin atm yang semakin meluas di wilayah Indonesia. Hal ini memicu PT IBM untuk menempatkan engineer dibanyak wilayah untuk memenuhi kebutuhan services dan maintenance. Untuk itu dalam penelitian ini dikembangkan sebuah sistem informasi geografis untuk pemetaan mesin dan tracking engineer dengan pemanfaatan geolocation yang bertujuan untuk menampilkan peta digital beserta lokasi mesin dan engineer di seluruh Indonesia, yang akan memudahkan PT IBM dalam pemberian tugas kepada engineer untuk services dan maintenance ke lokasi mesin terdekat. Sistem ini dibangun menggunakan beberapa software open source yaitu, Node.JS dan Express.JS yang merupakan server-side javascript web platform, Handlebars untuk template engine, MySQL sebagai database storage, Postman yang berfungsi sebagai API (Application Program Interface testing, Google Maps API untuk implementasi peta digital dan juga Firebase Cloud Messaging (FCM untuk platform mengirim notifikasi dari web ke device engineer.Pengembangan Sistem Informasi Geografis Berbasis Node.JS untuk Pemetaan Mesin dan Tracking Engineer dengan Pemanfaatan Geolocation pada PT IBM Indonesia

  16. Software Reviews. Programs Worth a Second Look.

    Science.gov (United States)

    Schneider, Roxanne; Eiser, Leslie

    1989-01-01

    Reviewed are three computer software packages for use in middle/high school classrooms. Included are "MacWrite II," a word-processing program for MacIntosh computers; "Super Story Tree," a word-processing program for Apple and IBM computers; and "Math Blaster Mystery," for IBM, Apple, and Tandy computers. (CW)

  17. Using NetMaster to manage IBM networks

    Science.gov (United States)

    Ginsburg, Guss

    1991-01-01

    After defining a network and conveying its importance to support the activities at the JSC, the need for network management based on the size and complexity of the IBM SNA network at JSC is demonstrated. Network Management consists of being aware of component status and the ability to control resources to meet the availability and service needs of users. The concerns of the user are addressed as well as those of the staff responsible for managing the network. It is explained how NetMaster (a network management system for managing SNA networks) is used to enhance reliability and maximize service to SNA network users through automated procedures. The following areas are discussed: customization, problem and configuration management, and system measurement applications of NetMaster. Also, several examples are given that demonstrate NetMaster's ability to manage and control the network, integrate various product functions, as well as provide useful management information.

  18. Multivariate methods and forecasting with IBM SPSS statistics

    CERN Document Server

    Aljandali, Abdulkader

    2017-01-01

    This is the second of a two-part guide to quantitative analysis using the IBM SPSS Statistics software package; this volume focuses on multivariate statistical methods and advanced forecasting techniques. More often than not, regression models involve more than one independent variable. For example, forecasting methods are commonly applied to aggregates such as inflation rates, unemployment, exchange rates, etc., that have complex relationships with determining variables. This book introduces multivariate regression models and provides examples to help understand theory underpinning the model. The book presents the fundamentals of multivariate regression and then moves on to examine several related techniques that have application in business-orientated fields such as logistic and multinomial regression. Forecasting tools such as the Box-Jenkins approach to time series modeling are introduced, as well as exponential smoothing and naïve techniques. This part also covers hot topics such as Factor Analysis, Dis...

  19. Unloading at Cointrin Airport of the IBM 709 computer

    CERN Document Server

    CERN PhotoLab

    1960-01-01

    CERN's first computer, a huge vacuum-tube Ferranti Mercury, was installed in building 2 in 1958. With its 60 microsecond clock cycle, it was a million times slower than today's big computers. The Mercury took 3 months to install and filled a huge room, even so, its computational ability didn't quite match that of a modern pocket calculator. "Mass" storage was provided by four magnetic drums each holding 32K x 20 bits - not enough to hold the data from a single proton-proton collision in the LHC. It was replaced in 1960 by the IBM 709 computer, seen here being unloaded at Cointrin airport. Although it was taken over so quickly by transistor equipped machines, a small part of the Ferranti Mercury remains. The computer's engineers installed a warning bell to signal computing errors - it can still be found mounted on the wall in a corridor of building 2.

  20. Homomorphic encryption experiments on IBM's cloud quantum computing platform

    Science.gov (United States)

    Huang, He-Liang; Zhao, You-Wei; Li, Tan; Li, Feng-Guang; Du, Yu-Tao; Fu, Xiang-Qun; Zhang, Shuo; Wang, Xiang; Bao, Wan-Su

    2017-02-01

    Quantum computing has undergone rapid development in recent years. Owing to limitations on scalability, personal quantum computers still seem slightly unrealistic in the near future. The first practical quantum computer for ordinary users is likely to be on the cloud. However, the adoption of cloud computing is possible only if security is ensured. Homomorphic encryption is a cryptographic protocol that allows computation to be performed on encrypted data without decrypting them, so it is well suited to cloud computing. Here, we first applied homomorphic encryption on IBM's cloud quantum computer platform. In our experiments, we successfully implemented a quantum algorithm for linear equations while protecting our privacy. This demonstration opens a feasible path to the next stage of development of cloud quantum information technology.

  1. Migrating the CERN PS control system to IBM workstations

    CERN Document Server

    De Metz-Noblat, N

    1995-01-01

    The workstations used within the control system of the CERN PS accelerator complex are not produced any more. We had therefore to review the software primary used as user interface and we achieved a port to IBM workstations. We are also preparing the maintenance of this code for the next ten years with minimal staff. This implies a clear separation between general computing facilities, control system developments, and operation. In order to share our experience, we will try to summarize various aspects of this migration: - system installation principles used to speed-up error recovery time and long-term maintenance costs, - problems correlated with the coexistence of two different platforms during migration, - software problems due to the platform and operating system changes, - hidden dependencies from a specific manufacturer.

  2. IBM system/360 assembly language interval arithmetic software

    Science.gov (United States)

    Phillips, E. J.

    1972-01-01

    Computer software designed to perform interval arithmetic is described. An interval is defined as the set of all real numbers between two given numbers including or excluding one or both endpoints. Interval arithmetic consists of the various elementary arithmetic operations defined on the set of all intervals, such as interval addition, subtraction, union, etc. One of the main applications of interval arithmetic is in the area of error analysis of computer calculations. For example, it has been used sucessfully to compute bounds on sounding errors in the solution of linear algebraic systems, error bounds in numerical solutions of ordinary differential equations, as well as integral equations and boundary value problems. The described software enables users to implement algorithms of the type described in references efficiently on the IBM 360 system.

  3. Investigation of triaxiality in 54122-128Xe isotopes in the framework of sdg-IBM

    Science.gov (United States)

    Jafarizadeh, M. A.; Ranjbar, Z.; Fouladi, N.; Ghapanvari, M.

    In this paper, a transitional interacting boson model (IBM) Hamiltonian in both sd-(IBM) and sdg-IBM versions based on affine SU(1, 1) Lie algebra is employed to describe deviations from the gamma-unstable nature of Hamiltonian along the chain of Xe isotopes. sdg-IBM Hamiltonian proposed a better interpretation of this deviation which cannot be explained in the sd-boson models. The nuclei studied have well-known γ bands close to the γ-unstable limit. The energy levels, B(E2) transition rates and signature splitting of the γ -vibrational band are calculated via the affine SU(1,1) Lie algebra. An acceptable degree of agreement was achieved based on this procedure. It is shown that in these isotopes the signature splitting is better reproduced by the inclusion of sdg-IBM. In none of them, any evidence for a stable, triaxial ground state shape is found.

  4. GAUSSIAN BEAM LASER RESONATOR PROGRAM

    Science.gov (United States)

    Cross, P. L.

    1994-01-01

    In designing a laser cavity, the laser engineer is frequently concerned with more than the stability of the resonator. Other considerations include the size of the beam at various optical surfaces within the resonator or the performance of intracavity line-narrowing or other optical elements. Laser resonators obey the laws of Gaussian beam propagation, not geometric optics. The Gaussian Beam Laser Resonator Program models laser resonators using Gaussian ray trace techniques. It can be used to determine the propagation of radiation through laser resonators. The algorithm used in the Gaussian Beam Resonator program has three major components. First, the ray transfer matrix for the laser resonator must be calculated. Next calculations of the initial beam parameters, specifically, the beam stability, the beam waist size and location for the resonator input element, and the wavefront curvature and beam radius at the input surface to the first resonator element are performed. Finally the propagation of the beam through the optical elements is computed. The optical elements can be modeled as parallel plates, lenses, mirrors, dummy surfaces, or Gradient Index (GRIN) lenses. A Gradient Index lens is a good approximation of a laser rod operating under a thermal load. The optical system may contain up to 50 elements. In addition to the internal beam elements the optical system may contain elements external to the resonator. The Gaussian Beam Resonator program was written in Microsoft FORTRAN (Version 4.01). It was developed for the IBM PS/2 80-071 microcomputer and has been implemented on an IBM PC compatible under MS DOS 3.21. The program was developed in 1988 and requires approximately 95K bytes to operate.

  5. 77 FR 19719 - Whirlpool Corporation Including On-Site Leased Workers From Career Solutions TEC Staffing, IBM...

    Science.gov (United States)

    2012-04-02

    ... Solutions TEC Staffing, IBM Corporation, TEK Systems Penske Logistics, Eurest, Canteen, Kelly Services, Inc...-site leased workers from Career Solutions TEC Staffing, IBM Corporation, TEK Systems, Penske Logistics...

  6. Commodity clusters: Performance comparison between PC`s and workstations

    Energy Technology Data Exchange (ETDEWEB)

    Carter, R.; Laroco, J.; Armstrong, R.

    1996-03-01

    Workstation clusters were originally developed as a way to leverage the better cost basis of UNIX workstations to perform computations previously handled only by relatively more expensive supercomputers. Commodity workstation clusters take this evolutionary process one step further by replacing equivalent proprietary workstation functionality with less expensive PC technology. As PC technology encroaches on proprietary UNIX workstation vendor markets, these vendors will see a declining share of the overall market. As technology advances continue, the ability to upgrade a workstations performance plays a large role in cost analysis. For example, a major upgrade to a typical UNIX workstation means replacing the whole machine. As major revisions to the UNIX vendor`s product line come out, brand new systems are introduced. IBM compatibles, however, are modular by design, and nothing need to be replaced except the components that are truly improved. The DAISy cluster, for example, is about to undergo a major upgrade from 90MHz Pentiums to 200MHz Pentium Pros. All of the memory -- the system`s largest expense -- and disks, power supply, etc., can be reused. As a result, commodity workstation clusters ought to gain an increasingly large share of the distributed computing market.

  7. Towards high performance computing for molecular structure prediction using IBM Cell Broadband Engine--an implementation perspective.

    Science.gov (United States)

    Krishnan, S P T; Liang, Sim Sze; Veeravalli, Bharadwaj

    2010-01-18

    RNA structure prediction problem is a computationally complex task, especially with pseudo-knots. The problem is well-studied in existing literature and predominantly uses highly coupled Dynamic Programming (DP) solutions. The problem scale and complexity become embarrassingly humungous to handle as sequence size increases. This makes the case for parallelization. Parallelization can be achieved by way of networked platforms (clusters, grids, etc) as well as using modern day multi-core chips. In this paper, we exploit the parallelism capabilities of the IBM Cell Broadband Engine to parallelize an existing Dynamic Programming (DP) algorithm for RNA secondary structure prediction. We design three different implementation strategies that exploit the inherent data, code and/or hybrid parallelism, referred to as C-Par, D-Par and H-Par, and analyze their performances. Our approach attempts to introduce parallelism in critical sections of the algorithm. We ran our experiments on SONY Play Station 3 (PS3), which is based on the IBM Cell chip. Our results suggest that introducing parallelism in DP algorithm allows it to easily handle longer sequences which otherwise would consume a large amount of time in single core computers. The results further demonstrate the speed-up gain achieved in exploiting the inherent parallelism in the problem and also elicits the advantages of using multi-core platforms towards designing more sophisticated methodologies for handling a fairly long sequence of RNA. The speed-up performance reported here is promising, especially when sequence length is long. To the best of our literature survey, the work reported in this paper is probably the first-of-its-kind to utilize the IBM Cell Broadband Engine (a heterogeneous multi-core chip) to implement a DP. The results also encourage using multi-core platforms towards designing more sophisticated methodologies for handling a fairly long sequence of RNA to predict its secondary structure.

  8. BASIC program estimates steam flow in blowoff lines

    Energy Technology Data Exchange (ETDEWEB)

    Ganapathy, V.

    1985-07-01

    This article provides in detail the computer program designed to estimate steam blowing of pipelines, performed to remove such things as mill scale and debris. Too high a steam flow results in pipe erosion, while too low a flow may not adequately clean the lines. The general procedure is to operate the boiler at a pressure that will produce the required flow when the steam is allowed to escape to the atmosphere through the pipelines being cleaned. Under these conditions, usually, sonic velocity is achieved at the pipe exit and the usual formula which relates flow to pressure drop is not applicable. The program provided can be run directly on the IBM PC or equivalent systems.

  9. 75 FR 62002 - Airworthiness Directives; Pilatus Aircraft Ltd. Models PC-6, PC-6-H1, PC-6-H2, PC-6/350, PC-6/350...

    Science.gov (United States)

    2010-10-07

    ... Maintenance Manual (AMM) of PC-6 B2-H2 and B2-H4 models does not include a Chapter 04 in the Airworthiness Limitations Section (ALS). For PC-6 models other than B2-H2 and B2- H4, no ALS at all is included in the AMM. With the latest Revision 12 of the AMM, a new Chapter 04 has been introduced in the AMM for PC-6 B2-H2...

  10. 76 FR 5467 - Airworthiness Directives; Pilatus Aircraft Ltd. Models PC-6, PC-6-H1, PC-6-H2, PC-6/350, PC-6/350...

    Science.gov (United States)

    2011-02-01

    ... Maintenance Manual (AMM) of PC-6 B2-H2 and B2-H4 models does not include a Chapter 04 in the Airworthiness Limitations Section (ALS). For PC-6 models other than B2-H2 and B2- H4, no ALS at all is included in the AMM. With the latest Revision 12 of the AMM, a new Chapter 04 has been introduced in the AMM for PC-6 B2-H2...

  11. NASTRAN data generation of helicopter fuselages using interactive graphics. [preprocessor system for finite element analysis using IBM computer

    Science.gov (United States)

    Sainsbury-Carter, J. B.; Conaway, J. H.

    1973-01-01

    The development and implementation of a preprocessor system for the finite element analysis of helicopter fuselages is described. The system utilizes interactive graphics for the generation, display, and editing of NASTRAN data for fuselage models. It is operated from an IBM 2250 cathode ray tube (CRT) console driven by an IBM 370/145 computer. Real time interaction plus automatic data generation reduces the nominal 6 to 10 week time for manual generation and checking of data to a few days. The interactive graphics system consists of a series of satellite programs operated from a central NASTRAN Systems Monitor. Fuselage structural models including the outer shell and internal structure may be rapidly generated. All numbering systems are automatically assigned. Hard copy plots of the model labeled with GRID or elements ID's are also available. General purpose programs for displaying and editing NASTRAN data are included in the system. Utilization of the NASTRAN interactive graphics system has made possible the multiple finite element analysis of complex helicopter fuselage structures within design schedules.

  12. Issues Identified During September 2016 IBM OpenMP 4.5 Hackathon

    Energy Technology Data Exchange (ETDEWEB)

    Richards, David F. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2017-03-15

    In September, 2016 IBM hosted an OpenMP 4.5 Hackathon at the TJ Watson Research Center. Teams from LLNL, ORNL, SNL, LANL, and LBNL attended the event. As with the 2015 hackathon, IBM produced an extremely useful and successful event with unmatched support from compiler team, applications staff, and facilities. Approximately 24 IBM staff supported 4-day hackathon and spent significant time 4-6 weeks out to prepare environment and become familiar with apps. This hackathon was also the first event to feature LLVM & XL C/C++ and Fortran compilers. This report records many of the issues encountered by the LLNL teams during the hackathon.

  13. Adoption of open source software in business models: a Red Hat and IBM case study

    CSIR Research Space (South Africa)

    Munga, N

    2009-10-01

    Full Text Available and defence to healthcare and life sciences, to media and entertainment. The lists of both offerings and clients are extensive. After 10 years of exposure and experience, open source has had a significant impact on the way that IBM carries out its business... more effectively [17]. IBM's first open source spin out came from a pre-production Research and Development project beginning in early 1996. Two IBM researchers developed a prototype Java compiler that was more efficient than Sun's industry standard...

  14. TABLE AND CHAIRS CRAFTSMAN IBM IN BULADU VILLAGE GORONTALO DISTRICT

    Directory of Open Access Journals (Sweden)

    Ayuddin Ayuddin

    2017-04-01

    Full Text Available The Gorontalo Community still rely on tables and chairs furniture made from rattan, but along with the time, tables and chairs from rattan is already becoming obsolete, one reason is growing furniture design that more convincing than other materials such as wood and aluminum. The society Devotion (IBM will provide re-design solutions for a table and chairs made from rattan by considering three main concepts, namely efficiency, aesthetic, and functional. With this concept can produce tables and chairs that are more innovative, powerful, and has a higher aesthetic so that it becomes a product of superior competition. Specific targets to be achieved is the increase: 1 knowledge and skills about designing tables and chairs from rattan using three concepts, namely efficiency, aesthetic, and functional, 2 increased revenue artisans from rattan tables and chairs. In addition to these targets, also the administrative improvement craftsmen and marketing management. The method used is the training and assistance directly to the artisans of the strategies and techniques in the manufacture of tables and chairs made of rattan. The results are expected to be an increase in the sale price so that the welfare of artisans tables and chairs to be better in the future.

  15. Transfer Of Baffle Data Between Macintosh PC And APART

    Science.gov (United States)

    Wise, Timothy D.; Ely, Philip A.

    1989-04-01

    Opto-mechanical systems which are entered into APART for straylight analysis frequently start out as models on a mechanical drafting program such as ANVIL. A translator, described elsewhere, has been coded in FORTRAN which will create the commands for a program one input file in APART based on an existing mechanical model in ANVIL. Having established this link, it is desirable to transfer the resulting opto-mechanical model to a personal computer (PC) for the purpose of report generation. Even more interesting is the ability to modify this model on the PC or to originate a completely new model on the PC for uplink to ANVIL. Using the program CADMOVER, we have effected two way transfers between a VAX computer and an Apple MacIntosh computer. Examples of this activity are provided.

  16. IBM Eesti loodab ELiga liitumisest tulu lõigata / Annika Matson

    Index Scriptorium Estoniae

    Matson, Annika, 1976-

    2003-01-01

    Maailma juhtiva infotehnoloogiafirma IBM Eesti tütarettevõte näeb Eesti liitumises Euroopa Liiduga endale uusi võimalusi Euroopa turul, eriti dokumendihalduse valdkonnas. Diagramm: IBMi aktsia viimased kolm aastat

  17. Mathematical analysis for the performance assessment of space communication parameters, IBM-360 version

    Science.gov (United States)

    Grayson, L.

    1972-01-01

    Development of equations to determine communication capability of pulse or digital transmission link is discussed. Equation specifies probability detection error for one-way transmission. Analysis is conducted on IBM 360 computer using FORTRAN 4.

  18. PC Tutor. Bericht uber ein PC-gestutzes Tutorensystem = PC Tutor. Report on a Tutoring System with Personal Computer. ZIFF Papiere 75.

    Science.gov (United States)

    Fritsch, Helmut

    A project was conducted to increase as well as to professionalize communication between tutors and learners in a West German university's distance education program by the use of personal computers. Two tutors worked on the systematic development of a PC-based correcting system. The goal, apart from developing general language skills in English,…

  19. User's manual for the Gaussian windows program

    Science.gov (United States)

    Jaeckel, Louis A.

    1992-01-01

    'Gaussian Windows' is a method for exploring a set of multivariate data, in order to estimate the shape of the underlying density function. The method can be used to find and describe structural features in the data. The method is described in two earlier papers. I assume that the reader has access to both of these papers, so I will not repeat material from them. The program described herein is written in BASIC and it runs on an IBM PC or PS/2 with the DOS 3.3 operating system. Although the program is slow and has limited memory space, it is adequate for experimenting with the method. Since it is written in BASIC, it is relatively easy to modify. The program and some related files are available on a 3-inch diskette. A listing of the program is also available. This user's manual explains the use of the program. First, it gives a brief tutorial, illustrating some of the program's features with a set of artificial data. Then, it describes the results displayed after the program does a Gaussian window, and it explains each of the items on the various menus.

  20. Why not make a PC cluster of your own? 2.State of the Art of PC Cluster and Basic Knowledge of Its Introduction

    Science.gov (United States)

    Himeno, Ryutaro; Shigetani, Takayuki; Kurokawa, Motoyoshi

    A PC cluster is no longer for enthusiasts but has become a cost effective computing platform ready to use. The largest problem for users is to modify their existing serial programs to parallel programs using the MPI. This modification is rather easy when the PC cluster is small, and the performance of the program shows high. This report describe basic knowledge and cost of introducing the PC cluster. We measured its performance by a Poisson benchmark test with several variations and report the results, too. We also mention the bottle neck of the performance and its solution.

  1. PC Based Linear Variable Differential Displacement Measurement Uses Optical Technique

    Directory of Open Access Journals (Sweden)

    Tapan Kumar MAITI

    2007-07-01

    Full Text Available PC based linear variable differential displacement (LVDD measurement with optical approach has been presented. The technique is a good blending of both hardware and software and is basically an alternative method of linear variable differential transformer (LVDT. A visual basic (VB programming is used for this PC based measurement. Here the voltage output and the displacement of the reflector can be studied and stored continuously. Theoretical predictions are supported by experimental results. This technique can be used for the measurement of some non-electrical parameters e.g. force, torque and liquid level etc.

  2. Data Mining and Knowledge Discover - IBM Cognitive Alternatives for NASA KSC

    Science.gov (United States)

    Velez, Victor Hugo

    2016-01-01

    Skillful tools in cognitive computing to transform industries have been found favorable and profitable for different Directorates at NASA KSC. In this study is shown how cognitive computing systems can be useful for NASA when computers are trained in the same way as humans are to gain knowledge over time. Increasing knowledge through senses, learning and a summation of events is how the applications created by the firm IBM empower the artificial intelligence in a cognitive computing system. NASA has explored and applied for the last decades the artificial intelligence approach specifically with cognitive computing in few projects adopting similar models proposed by IBM Watson. However, the usage of semantic technologies by the dedicated business unit developed by IBM leads these cognitive computing applications to outperform the functionality of the inner tools and present outstanding analysis to facilitate the decision making for managers and leads in a management information system.

  3. Description of mixed symmetry states in 96Ru using IBM-2

    Science.gov (United States)

    Zhang, DaLi; Mu, ChengFu

    2017-04-01

    We have investigated the properties of low-lying states in 96Ru within the framework of the neutron-proton interacting boson model (IBM-2), with special attention paid to the characteristics of the mixed symmetry states. By considering the relative energy of d proton boson to be different from that of neutron boson, the level energies and M1, E2 transition strengths have been calculated. The IBM-2 calculation is consistent with the experimental data of 96Ru both quantitatively and qualitatively. Particularly, the strong M1 transition between the 42 + and 41 + states has been reproduced nicely. The calculated results show that the M1 transition strength of B( M1; 42 + → 41 +) in 96Ru can be described successfully by the IBM-2.

  4. Quantitative analysis and IBM SPSS statistics a guide for business and finance

    CERN Document Server

    Aljandali, Abdulkader

    2016-01-01

    This guide is for practicing statisticians and data scientists who use IBM SPSS for statistical analysis of big data in business and finance. This is the first of a two-part guide to SPSS for Windows, introducing data entry into SPSS, along with elementary statistical and graphical methods for summarizing and presenting data. Part I also covers the rudiments of hypothesis testing and business forecasting while Part II will present multivariate statistical methods, more advanced forecasting methods, and multivariate methods. IBM SPSS Statistics offers a powerful set of statistical and information analysis systems that run on a wide variety of personal computers. The software is built around routines that have been developed, tested, and widely used for more than 20 years. As such, IBM SPSS Statistics is extensively used in industry, commerce, banking, local and national governments, and education. Just a small subset of users of the package include the major clearing banks, the BBC, British Gas, British Airway...

  5. Molecular treatment effects of alemtuzumab in skeletal muscles of patients with IBM.

    Science.gov (United States)

    Schmidt, Karsten; Kleinschnitz, Konstanze; Rakocevic, Goran; Dalakas, Marinos C; Schmidt, Jens

    2016-04-16

    Mechanisms of inflammation and protein accumulation are crucial in inclusion body myositis (IBM). Recent evidence demonstrated that intravenous immunoglobulin failed to suppress cell-stress mediators in IBM. Here we studied the molecular changes in skeletal muscle biopsies from patients with IBM before and after treatment with alemtuzumab. Relevant inflammatory and degeneration-associated markers were assessed by quantitative-PCR and immunohistochemistry in repeated muscle biopsy specimens from patients with IBM, which had been treated in a previously published uncontrolled proof-of-concept trial with alemtuzumab. There were no significant changes of the mRNA expression levels of the pro-inflammatory chemokines CXCL-9, CCL-4, and the cytokines IFN-γ, TGF-β, TNF-α, and IL-1β. Similarly, the degeneration-associated molecules ubiquitin, APP and αB-crystallin did not substantially change. Although no overall beneficial treatment effect was noted except for a 6-month stabilization, some patients experienced a transient improvement in muscle strength. In such responders, a trend towards reduced expression of inflammatory markers was noted. In contrast, the expression remained unchanged in the others who did not experience any change. The expression levels of IL-1β and MHC-I correlated with the positive clinical effect. By immunohistochemistry, some inflammatory mediators like CD8, CXCL-9, and MHC-I were downmodulated. However, no consistent changes were noted for ubiquitin, nitrotyrosin and β-amyloid. Alemtuzumab showed a trend towards downregulation of the expression of some inflammatory molecules in skeletal muscle of IBM patients but has no effect on several crucial markers of cell stress and degeneration. The data are helpful to explain the molecular treatment effects of future lymphocyte-targeted immunotherapies in IBM.

  6. A Rare Case of Sporadic Inclusion Body Myositis (s-IBM).

    Science.gov (United States)

    Acharya, Sourya; Shukla, Samarth; Kitey, Pritum; Khan, Shameem; Mahajan, S N

    2016-01-01

    Sporadic inclusion body myositis (s-IBM) is an acquired inflammatory myopathy. Clinical presentation is variable. The usual presentation is progressive weakness and atrophy of the arms and leg muscles, especially of the quadriceps femoris which is invariably affected. It is classified under inflammatory myopathies, along with polymyositis and dermatomyositis. We present a case of s-IBM who presented with gradually progressive quadriparesis with characteristic quadriceps wasting and weakness in neck flexors. Electromyography revealed myopathic potential and muscle biopsy revealed features of inclusion body myositis.

  7. Analysis list: Pc [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Pc Adult,Cell line,Embryo + dm3 http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/targ...et/Pc.1.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/target/Pc.5.tsv http://dbarchive.biosciencedbc.jp.../kyushu-u/dm3/target/Pc.10.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/colo/Pc.Adult.tsv,http://dbarchive.bioscience...dbc.jp/kyushu-u/dm3/colo/Pc.Cell_line.tsv,http://dbarchive.bioscience...dbc.jp/kyushu-u/dm3/colo/Pc.Embryo.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/dm3/colo/Adult.gml,http://dbarchive.bioscience

  8. SI PC104 Performance Test Report

    Energy Technology Data Exchange (ETDEWEB)

    Montelongo, S

    2005-12-16

    The Spectral Instruments (SI) PC104 systems associated with the SI-1000 CCD camera exhibited intermittent power problems during setup, test and operations which called for further evaluation and testing. The SI PC104 System is the interface between the SI-1000 CCD camera and its associated Diagnostic Controller (DC). As such, the SI PC104 must be a reliable, robust system capable of providing consistent performance in various configurations and operating conditions. This SI PC104 system consists of a stackable set of modules designed to meet the PC104+ Industry Standard. The SI PC104 System consists of a CPU module, SI Camera card, Media converter card, Video card and a I/O module. The root cause of power problems was identified as failing solder joints at the LEMO power connector attached to the SI Camera Card. The recommended solution was to provide power to the PC104 system via a PC104+ power supply module configured into the PC104 stack instead of thru the LEMO power connector. Test plans (2) were developed to test SI PC104 performance and identify any outstanding issues noted during extended operations. Test Plan 1 included performance and image acquisition tests. Test Plan 2 verified performance after implementing recommendations. Test Plan 2 also included verifying integrity of system files and driver installation after bootup. Each test plan was implemented to fully test against each set of problems noted. Test Plan presentations and Test Plan results are attached as appendices. Anticipated test results will show successful operation and reliable performance of the SI PC104 system receiving its power via a PC104 power supply module. A SI PC104 Usage Recommendation Memo will be sent out to the SI PC104 User Community. Recommendation memo(s) are attached as appendices.

  9. Data acquisition techniques using PC

    CERN Document Server

    Austerlitz, Howard

    1991-01-01

    Data Acquisition Techniques Using Personal Computers contains all the information required by a technical professional (engineer, scientist, technician) to implement a PC-based acquisition system. Including both basic tutorial information as well as some advanced topics, this work is suitable as a reference book for engineers or as a supplemental text for engineering students. It gives the reader enough understanding of the topics to implement a data acquisition system based on commercial products. A reader can alternatively learn how to custom build hardware or write his or her own software.

  10. IBM, CERN join to create a data-intensive management system

    CERN Multimedia

    2003-01-01

    "IBM, White Plains, N.Y., has agreed to collaborate with the European Organization for Nuclear Research's (CERN), Geneva, Switzerland, openlab for a DataGrid project. The aim is to develop a vast data-management system based on Grid computing to investigate the origins of the universe (1/2 page).

  11. Integrating Closed-loop Supply Chains and Spare Parts Management at IBM

    NARCIS (Netherlands)

    M. Fleischmann (Moritz); J.A.E.E. van Nunen (Jo); B. Graeve

    2002-01-01

    textabstractEver more companies are recognizing the benefits of closed-loop supply chains that integrate product returns into business operations. IBM has been among the pioneers seeking to unlock the value dormant in these resources. We report on a project exploiting product returns as a source of

  12. Letter from Hong Kong: A Report on Chinese Food, Fake Apples, and IBM's Asian Strategy.

    Science.gov (United States)

    Immel, A. Richard

    1984-01-01

    Notes that microcomputer use in Hong Kong's small business community does not reflect the growth of its high-tech electronics industry and discusses IBM's influence in Hong Kong and Asia, the counterfeiting of Apple microcomputers and software, and why Apple currently has no recourse. (MBR)

  13. Correspondence between phenomenological and IBM-1 models of even isotopes of Yb

    Science.gov (United States)

    A. Okhunov, A.; I. Sharrad, F.; Anwer, A. Al-Sammarraie; U. Khandaker, M.

    2015-08-01

    Energy levels and the reduced probability of E2- transitions for ytterbium isotopes with proton number Z = 70 and neutron numbers between 100 and 106 have been calculated through phenomenological (PhM) and interacting boson (IBM-1) models. The predicted low-lying levels (energies, spins and parities) and the reduced probability for E2- transitions results are reasonably consistent with the available experimental data. The predicted low-lying levels (gr-, β1- and γ1- band) produced in the PhM are in good agreement with the experimental data compared with those by IBM-1 for all nuclei of interest. In addition, the phenomenological model was successful in predicting the β2-, β3-, β4-, γ2- and 1+ - band while it was a failure with IBM-1. Also, the 3+- band is predicted by the IBM-1 model for 172Yb and 174Yb nuclei. All calculations are compared with the available experimental data. Supported by Fundamental Research Grant Scheme (FRGS) of Ministry of Higher Education of Malaysia (FRGS13-074-0315), Islamic Development Bank (IDB) (36/11201905/35/IRQ/D31, 37/IRQ/P30)

  14. Hazardous Waste Cleanup: IBM Corporation-TJ Watson Research Center in Yorktown Heights, New York

    Science.gov (United States)

    IBM Corporation -TJ Watson Research Center is located in southern Yorktown near the boundary separating the Town of Yorktown from the Town of New Castle. The site occupies an area of approximately 217 acres and adjoins land uses are predominantly residenti

  15. A controlled study of intravenous immunoglobulin combined with prednisone in the treatment of IBM.

    Science.gov (United States)

    Dalakas, M C; Koffman, B; Fujii, M; Spector, S; Sivakumar, K; Cupler, E

    2001-02-13

    To investigate whether the combination of intravenous immunoglobulin (IVIg) with prednisone improves muscle strength and alters endomysial inflammation in patients with sporadic inclusion body myositis (s-IBM). In a previous controlled trial in s-IBM, IVIg did not significantly improve strength in spite of modest benefits in some muscle groups. The possibility that prednisone may have a synergistic effect with IVIg prompted another controlled trial. Thirty-six patients with biopsy-proven IBM were randomized to receive IVIg or placebo monthly for 3 months. Before infusions, all patients were started on high-dose prednisone for 3 months. Primary outcome measures were differences in the 1) Quantitative Muscle Strength (QMT) testing; and 2) modified Medical Research Council (MRC) scores, between the patients randomized to IVIg + prednisone compared with those randomized to placebo + prednisone. Repeated open muscle biopsies were performed at random in 24 patients to determine changes in the number of autoinvasive T cells and necrotic muscle fibers. Nineteen patients were randomized to IVIg + prednisone and 17 to placebo + prednisone. No significant change was noted in muscle strength, assessed by QMT and MRC, from baseline to the 2nd, 3rd, or 4th month after treatment between the two groups. The number of necrotic fibers was reduced in the IVIg randomized group (p IBM. Endomysial inflammation was significantly reduced after treatment, but the reduction was not of clinical significance.

  16. Using IBMs to Investigate Spatially-dependent Processes in Landscape Genetics Theory

    Science.gov (United States)

    Much of landscape and conservation genetics theory has been derived using non-spatialmathematical models. Here, we use a mechanistic, spatially-explicit, eco-evolutionary IBM to examine the utility of this theoretical framework in landscapes with spatial structure. Our analysis...

  17. Hazardous Waste Cleanup: IBM Corporation, Former in Hopewell Junction, New York

    Science.gov (United States)

    IBM's facility is located in Hopewell Junction, New York, bordered on the north by U.S. Route 52, to the east by County Highway 27, and to the south by U.S. Route 84. There is an unnamed creek next to the surrounding open fields to the west. The 592-acre

  18. IBM-i ja Lenovo juhid külastasid Eestit

    Index Scriptorium Estoniae

    2006-01-01

    8.-9. maini 2006. a. viibisid Tallinnas IBM-Lenovo Alliance'i viitsepresident Simon L. Porter ja Lenovo Soome regiooni juhataja Jukka Mäntylä, kes kohtusid kohaliku IT-pressiga ning esitlesid Tallinna Botaanikaaia Palmimaja seminarikeskuses mõlema firma uudiseid

  19. A framework for WRF to WRF-IBM grid nesting to enable multiscale simulations

    Energy Technology Data Exchange (ETDEWEB)

    Wiersema, David John [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Univ. of California, Berkeley, CA (United States); Lundquist, Katherine A. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Chow, Fotini Katapodes [Univ. of California, Berkeley, CA (United States)

    2016-09-29

    With advances in computational power, mesoscale models, such as the Weather Research and Forecasting (WRF) model, are often pushed to higher resolutions. As the model’s horizontal resolution is refined, the maximum resolved terrain slope will increase. Because WRF uses a terrain-following coordinate, this increase in resolved terrain slopes introduces additional grid skewness. At high resolutions and over complex terrain, this grid skewness can introduce large numerical errors that require methods, such as the immersed boundary method, to keep the model accurate and stable. Our implementation of the immersed boundary method in the WRF model, WRF-IBM, has proven effective at microscale simulations over complex terrain. WRF-IBM uses a non-conforming grid that extends beneath the model’s terrain. Boundary conditions at the immersed boundary, the terrain, are enforced by introducing a body force term to the governing equations at points directly beneath the immersed boundary. Nesting between a WRF parent grid and a WRF-IBM child grid requires a new framework for initialization and forcing of the child WRF-IBM grid. This framework will enable concurrent multi-scale simulations within the WRF model, improving the accuracy of high-resolution simulations and enabling simulations across a wide range of scales.

  20. Research center Juelich to install Germany's most powerful supercomputer new IBM System for science and research will achieve 5.8 trillion computations per second

    CERN Multimedia

    2002-01-01

    "The Research Center Juelich, Germany, and IBM today announced that they have signed a contract for the delivery and installation of a new IBM supercomputer at the Central Institute for Applied Mathematics" (1/2 page).

  1. Demystifying Virtual Communities of Practice: A Case Study of IBM

    Science.gov (United States)

    Kok, Ayse

    2010-01-01

    The purpose of this proposed research study is to empirically explore the nature of virtual communities of practice (CoP) in a global organisation within the context of its International Corporate Volunteer (ICV) Program. This study investigates whether and how the use of virtual CoP evolves and becomes embedded within this organization. Following…

  2. IESIP - AN IMPROVED EXPLORATORY SEARCH TECHNIQUE FOR PURE INTEGER LINEAR PROGRAMMING PROBLEMS

    Science.gov (United States)

    Fogle, F. R.

    1994-01-01

    IESIP, an Improved Exploratory Search Technique for Pure Integer Linear Programming Problems, addresses the problem of optimizing an objective function of one or more variables subject to a set of confining functions or constraints by a method called discrete optimization or integer programming. Integer programming is based on a specific form of the general linear programming problem in which all variables in the objective function and all variables in the constraints are integers. While more difficult, integer programming is required for accuracy when modeling systems with small numbers of components such as the distribution of goods, machine scheduling, and production scheduling. IESIP establishes a new methodology for solving pure integer programming problems by utilizing a modified version of the univariate exploratory move developed by Robert Hooke and T.A. Jeeves. IESIP also takes some of its technique from the greedy procedure and the idea of unit neighborhoods. A rounding scheme uses the continuous solution found by traditional methods (simplex or other suitable technique) and creates a feasible integer starting point. The Hook and Jeeves exploratory search is modified to accommodate integers and constraints and is then employed to determine an optimal integer solution from the feasible starting solution. The user-friendly IESIP allows for rapid solution of problems up to 10 variables in size (limited by DOS allocation). Sample problems compare IESIP solutions with the traditional branch-and-bound approach. IESIP is written in Borland's TURBO Pascal for IBM PC series computers and compatibles running DOS. Source code and an executable are provided. The main memory requirement for execution is 25K. This program is available on a 5.25 inch 360K MS DOS format diskette. IESIP was developed in 1990. IBM is a trademark of International Business Machines. TURBO Pascal is registered by Borland International.

  3. Ada Compiler Validation Summary Report: Certificate Number: 881216N1. 10013, Alsys Limited, AlsyCOMP 013, Version 4.1, IBM PC/AT/IBM 9370 Model 90

    Science.gov (United States)

    1988-12-16

    identifies behaviour that is implementation-dependent but permitted by the Ada Standard. Six classes of tests are uggd-- These tests are designed to...determine that the implementation-dependent behaviour is allowed by the Ada Standard Testing of this compiler was conducted by The National Computing... nonconformities to the Ada Standard other than those presented. Copies of this report are available to the public from: Ada Information Clearinghouse

  4. GOC: General Orbit Code. [In FORTRAN for IBM 360

    Energy Technology Data Exchange (ETDEWEB)

    Maddox, L.B.; McNeilly, G.S.

    1979-08-01

    GOC (General Orbit Code) is a versatile program which will perform a variety of calculations relevant to isochronous cyclotron design studies. In addition to the usual calculations of interest (e.g., equilibrium and accelerated orbits, focusing frequencies, field isochronization, etc.), GOC has a number of options to calculate injections with a charge change. GOC provides both printed and plotted output, and will follow groups of particles to allow determination of finite-beam properties. An interactive PDP-10 program called GIP, which prepares input data for GOC, is available. GIP is a very easy and convenient way to prepare complicated input data for GOC. Enclosed with this report are several microfiche containing source listings of GOC and other related routines and the printed output from a multiple-option GOC run.

  5. xdamp Version 3: An IDL{reg_sign}-based data and image manipulation program

    Energy Technology Data Exchange (ETDEWEB)

    Ballard, W.P.

    1998-05-01

    The original DAMP (DAta Manipulation Program) was written by Mark Hedemann of Sandia National Laboratories and used the CA-DISSPLA{trademark} (available from Computer Associates International, Inc., Garden City, NY) graphics package as its engine. It was used to plot, modify, and otherwise manipulate the one-dimensional data waveforms (data vs. time) from a wide variety of accelerators. With the waning of CA-DISSPLA and the increasing popularity of Unix{reg_sign}-based workstations, a replacement was needed. This package uses the IDL{reg_sign} software, available from Research Systems Incorporated in Boulder, Colorado, as the engine, and creates a set of widgets to manipulate the data in a manner similar to the original DAMP and earlier versions of xdamp. IDL is currently supported on a wide variety of Unix platforms such as IBM{reg_sign} workstations, Hewlett Packard workstations, SUN{reg_sign} workstations, Microsoft{reg_sign} Windows{trademark} computers, Macintosh{reg_sign} computers and Digital Equipment Corporation VMS{reg_sign} and Alpha{reg_sign} systems. Thus, xdamp is portable across many platforms. The author has verified operation, albeit with some minor IDL bugs, on personal computers using Windows 95 and Windows NT; IBM Unix platforms; and DEC alpha and VMS systems; HP 9000/700 series workstations; and Macintosh computers, both regular and PowerPC{trademark} versions. Version 3 adds the capability to manipulate images to the original xdamp capabilities.

  6. HOTSPOT Health Physics codes for the PC

    Energy Technology Data Exchange (ETDEWEB)

    Homann, S.G.

    1994-03-01

    The HOTSPOT Health Physics codes were created to provide Health Physics personnel with a fast, field-portable calculation tool for evaluating accidents involving radioactive materials. HOTSPOT codes are a first-order approximation of the radiation effects associated with the atmospheric release of radioactive materials. HOTSPOT programs are reasonably accurate for a timely initial assessment. More importantly, HOTSPOT codes produce a consistent output for the same input assumptions and minimize the probability of errors associated with reading a graph incorrectly or scaling a universal nomogram during an emergency. The HOTSPOT codes are designed for short-term (less than 24 hours) release durations. Users requiring radiological release consequences for release scenarios over a longer time period, e.g., annual windrose data, are directed to such long-term models as CAPP88-PC (Parks, 1992). Users requiring more sophisticated modeling capabilities, e.g., complex terrain; multi-location real-time wind field data; etc., are directed to such capabilities as the Department of Energy`s ARAC computer codes (Sullivan, 1993). Four general programs -- Plume, Explosion, Fire, and Resuspension -- calculate a downwind assessment following the release of radioactive material resulting from a continuous or puff release, explosive release, fuel fire, or an area contamination event. Other programs deal with the release of plutonium, uranium, and tritium to expedite an initial assessment of accidents involving nuclear weapons. Additional programs estimate the dose commitment from the inhalation of any one of the radionuclides listed in the database of radionuclides; calibrate a radiation survey instrument for ground-survey measurements; and screen plutonium uptake in the lung (see FIDLER Calibration and LUNG Screening sections).

  7. The business value of DB2 for z/OS IBM DB2 analytics accelerator and optimizer

    CERN Document Server

    Campbell, John; Li, Ruiping; Parekh, Surekha; Purcell, Terry

    2013-01-01

    Celebrating the 30th anniversary of the first release of DB2, this book highlights the important milestones, capabilities, and impacts of the database management software for IBM's mainframe operating system. Special focus is given to IBM DB2 Analytics Accelerator, covering the key design and operational aspects that enable IBM DB2 for z/OS clients to benefit from faster performance, reduced CPU usage, and lower costs. The second half of the book discusses performance enhancements and cost-saving measures in the version 10 release and is rich with hints and tips for a successful upgrade. A spe

  8. Virtual reality exposure therapy: 150-degree screen to desktop PC.

    Science.gov (United States)

    Tichon, Jennifer; Banks, Jasmine

    2006-08-01

    Virtual reality exposure therapy (VRET) developed using immersive or semi-immersive virtual environments present a usability problem for practitioners. To meet practitioner requirements for lower cost and portability VRET programs must often be ported onto desktop environments such as the personal computer (PC). However, success of VRET has been shown to be linked to presence, and the environment's ability to evoke the same reactions and emotions as a real experience. It is generally accepted that high-end virtual environments (VEs) are more immersive than desktop PCs, but level of immersion does not always predict level of presence. This paper reports on the impact on presence of porting a therapeutic VR application for schizophrenia from the initial research environment of a semi-immersive curved screen to PC. Presence in these two environments is measured both introspectively and across a number of causal factors thought to underlie the experience of presence. Results show that the VR exposure program successfully made users feel they were "present" in both platforms. While the desktop PC achieved higher scores on presence across causal factors participants reported they felt more present in the curved screen environment. While comparison of the two groups was statistically significant for the PQ but not for the IPQ, subjective reports of experiences in the environments should be considered in future research as the success of VRET relies heavily on the emotional response of patients to the therapeutic program.

  9. QTL Mapping of Low-Temperature Germination Ability in the Maize IBM Syn4 RIL Population.

    Science.gov (United States)

    Hu, Shuaidong; Lübberstedt, Thomas; Zhao, Guangwu; Lee, Michael

    2016-01-01

    Low temperature is the primary factor to affect maize sowing in early spring. It is, therefore, vital for maize breeding programs to improve tolerance to low temperatures at seed germination stage. However, little is known about maize QTL involved in low-temperature germination ability. 243 lines of the intermated B73×Mo17 (IBM) Syn4 recombinant inbred line (RIL) population was used for QTL analysis of low-temperature germination ability. There were significant differences in germination-related traits under both conditions of low temperature (12°C/16 h, 18°C/8 h) and optimum temperature (28°C/24 h) between the parental lines. Only three QTL were identified for controlling optimum-temperature germination rate. Six QTL controlling low-temperature germination rate were detected on chromosome 4, 5, 6, 7 and 9, and contribution rate of single QTL explained between 3.39%~11.29%. In addition, six QTL controlling low-temperature primary root length were detected in chromosome 4, 5, 6, and 9, and the contribution rate of single QTL explained between 3.96%~8.41%. Four pairs of QTL were located at the same chromosome position and together controlled germination rate and primary root length under low temperature condition. The nearest markers apart from the corresponding QTL (only 0.01 cM) were umc1303 (265.1 cM) on chromosome 4, umc1 (246.4 cM) on chromosome 5, umc62 (459.1 cM) on chromosome 6, bnl14.28a (477.4 cM) on chromosome 9, respectively. A total of 3155 candidate genes were extracted from nine separate intervals based on the Maize Genetics and Genomics Database (http://www.maizegdb.org). Five candidate genes were selected for analysis as candidates putatively affecting seed germination and seedling growth at low temperature. The results provided a basis for further fine mapping, molecular marker assisted breeding and functional study of cold-tolerance at the stage of seed germination in maize.

  10. Survivability enhancement study for C/sup 3/I/BM (communications, command, control and intelligence/battle management) ground segments: Final report

    Energy Technology Data Exchange (ETDEWEB)

    1986-10-30

    This study involves a concept developed by the Fairchild Space Company which is directly applicable to the Strategic Defense Initiative (SDI) Program as well as other national security programs requiring reliable, secure and survivable telecommunications systems. The overall objective of this study program was to determine the feasibility of combining and integrating long-lived, compact, autonomous isotope power sources with fiber optic and other types of ground segments of the SDI communications, command, control and intelligence/battle management (C/sup 3/I/BM) system in order to significantly enhance the survivability of those critical systems, especially against the potential threats of electromagnetic pulse(s) (EMP) resulting from high altitude nuclear weapon explosion(s). 28 figs., 2 tabs.

  11. Solar energy system performance evaluation: seasonal report for IBM System 3, Glendo, Wyoming

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-06-01

    The IBM System 3 Solar Energy System was designed by the Federal Systems Division of IBM in Huntsville, Alabama to provide 46% of the space heating and 80% of the domestic hot water (DHW) for a 1078 square foot retrofit of an existing building used as a residence at the Glendo Reservoir State Park Ranger Station. The system consists of fourteen Sunworks Model LA1001A flat plate liquid collectors (294 square feet), a 1000 gallon hot water storage tank, a 65 gallon electric domestic hot water tank, pumps, heat exchangers, controls, and associated plumbing. Water is the heat transfer medium for this closed volume, passive drain down system. A gas furnace is used for auxiliary space heating energy. The system which became operational in October 1978 has five modes of operation. Performance data for the year of 1979 are presented and assessed.

  12. IbM HIMPAUDI KECAMATAN KALIWUNGU KENDAL DALAM RANGKA PENYUSUNAN PERANGKAT PEMBELAJARAN KURIKULUM 2013

    Directory of Open Access Journals (Sweden)

    Agung Prasetyo

    2016-10-01

    Full Text Available Rendahnya motivasi guru dalam menyusun perangkat pembelajaran Kurikulum 2013 (K13 menjadi landasan bagi tim IbM untuk melaksanakan kegiatan pelatihan. Selama ini sebagian besar guru-guru disekolah hanya melakukan penyusunan perangkat pembelajaran sebagaimana yang mereka pahami. Melalui kegiatan IbM pelatihan Penyusunan Perangkat Pembelajaran K-13 bagi guru-guru PAUD se-Kecamatan Kaliwungu, Setelah kegiatan pelatihan para guru tidak dilepas begitu saja, tetapi  dilanjutkan dengan pendampingan  dan  pemantauan  selama  kegiatan  pembelajaran  dan  implementasi  Kurikulum 2013 berlangsung, sehingga keraguan dan kebingungan itu dapat terjawab. Dari hasil pendampingan dan pemantauan dapat menjadi bahan evaluasi bagi semua pihak untuk perbaikan dikegiatan pembelajaran, dan selanjutnya digunakan sebagai penyempurnaan.   Kata Kunci: Penyusunan, Perangkat Pembelajaran Kurikulum 13, Guru PAUD

  13. Simulation Technology Research Division assessment of the IBM RISC SYSTEM/6000 Model 530 workstation

    Energy Technology Data Exchange (ETDEWEB)

    Valdez, G.D. (Applied Methods, Inc., Albuquerque, NM (USA)); Halbleib, J.A.; Kensek, R.P.; Lorence, L.J. (Sandia National Labs., Albuquerque, NM (USA))

    1990-11-01

    A workstation manufactured by International Business Machines Corporation (IBM) was loaned to the Simulation Technology Research Division for evaluation. We have found that these new UNIX workstations from IBM have superior cost to performance ratios compared to the CRAY supercomputers and Digital's VAX machines. Our appraisal of this workstation included floating-point performance, system and environment functionality, and cost effectiveness. Our assessment was based on a suite of radiation transport codes developed at Sandia that constitute the bulk of our division's computing workload. In this report, we also discuss our experience with features that are unique to this machine such as the AIX operating system and the XLF Fortran Compiler. The interoperability of the RS/6000 workstation with Sandia's network of CRAYs and VAXs was also assessed.

  14. George E. Pake Prize Lecture: Physical Sciences Research at IBM: Still at the Cutting Edge

    Science.gov (United States)

    Theis, Thomas

    2015-03-01

    The information technology revolution is in its ``build out'' phase. The foundational scientific insights and hardware inventions are now many decades old. The microelectronics industry is maturing. An increasing fraction of the total research investment is in software and services, as applications of information technology transform every business and every sector of the public and private economy. Yet IBM Research continues to make substantial investments in hardware technology and the underlying physical sciences. While some of this investment is aimed at extending the established transistor technology, an increasing fraction is aimed at longer-term and possibly disruptive research - new devices for computing, such as tunneling field-effect transistors and nanophotonic circuits, and new architectures, such as neurosynaptic systems and quantum computing. This research investment is a bet that the old foundations of information technology are ripe for reinvention. After all, today's information technology devices and systems operate far from any fundamental limits on speed and energy efficiency. But how can IBM make risky long-term research investments in an era of global competition, with financial markets focused on the short term? One important answer is partnerships. Since its early days, IBM Research has pursued innovation in information technology and innovation in the ways it conducts the business of research. By continuously evolving new models for research and development partnerships, it has extended its global reach, increased its impact on IBM's customers, and expanded the breadth and depth of its research project portfolio. Research in the physical sciences has often led the way. Currently on assignment to the Semiconductor Research Corporation.

  15. Engineering PFLOTRAN for Scalable Performance on Cray XT and IBM BlueGene Architectures

    Energy Technology Data Exchange (ETDEWEB)

    Mills, Richard T [ORNL; Sripathi, Vamsi K [ORNL; Mahinthakumar, Gnanamanika [ORNL; Hammond, Glenn [Pacific Northwest National Laboratory (PNNL); Lichtner, Peter [Los Alamos National Laboratory (LANL); Smith, Barry F [Argonne National Laboratory (ANL)

    2010-01-01

    We describe PFLOTRAN - a code for simulation of coupled hydro-thermal-chemical processes in variably saturated, non-isothermal, porous media - and the approaches we have employed to obtain scalable performance on some of the largest scale supercomputers in the world. We present detailed analyses of I/O and solver performance on Jaguar, the Cray XT5 at Oak Ridge National Laboratory, and Intrepid, the IBM BlueGene/P at Argonne National Laboratory, that have guided our choice of algorithms.

  16. Integrating Closed-loop Supply Chains and Spare Parts Management at IBM

    OpenAIRE

    Fleischmann, M.; van Nunen, J.A.E.E.; Graeve, B.

    2002-01-01

    textabstractEver more companies are recognizing the benefits of closed-loop supply chains that integrate product returns into business operations. IBM has been among the pioneers seeking to unlock the value dormant in these resources. We report on a project exploiting product returns as a source of spare parts. Key decisions include the choice of recovery opportunities to use, the channel design, and the coordination of alternative supply sources. We developed an analytic inventory control mo...

  17. Descriptive study of the even-even actinide nuclei 230 - 234Th isotopes using IBM-1

    Science.gov (United States)

    Al-Dahan, N.

    2017-06-01

    The nuclear structure of the actinide even-even thorium isotopes from A=230-234 have been investigated within the framework of the Interacting Boson Model (IBM-1). Predictions are given for the excited state energies for the ground state, β and γ-bands, the transition probabilities between these states, the rotational moment of inertia, and the energy staggering in the γ-band energies. The results of these calculations are compared with the experimental data on these isotopes.

  18. Performance of the AMS Offline software on the IBM Blue Gene/Q architecture

    Science.gov (United States)

    Choutko, V.; Egorov, A.; Shan, B. S.

    2017-10-01

    The Alpha Magnetic Spectrometer (AMS) is a high energy physics experiment installed and operating on board the International Space Station (ISS) since May 2011 and expected to last beyond 2024. The details of porting the AMS software to the IBM Blue Gene/Q Architecture are discussed. The performance of the AMS reconstruction and simulation software in that architecture is evaluated and compared to the performance obtained on Intel based architecture.

  19. OpenZika: An IBM World Community Grid Project to Accelerate Zika Virus Drug Discovery

    OpenAIRE

    Ekins, Sean; Perryman, Alexander L.; Horta Andrade, Carolina

    2016-01-01

    The Zika virus outbreak in the Americas has caused global concern. To help accelerate this fight against Zika, we launched the OpenZika project. OpenZika is an IBM World Community Grid Project that uses distributed computing on millions of computers and Android devices to run docking experiments, in order to dock tens of millions of drug-like compounds against crystal structures and homology models of Zika proteins (and other related flavivirus targets). This will enable the identification of...

  20. DNA methylation in an intron of the IBM1 histone demethylase gene stabilizes chromatin modification patterns.

    Science.gov (United States)

    Rigal, Mélanie; Kevei, Zoltán; Pélissier, Thierry; Mathieu, Olivier

    2012-06-29

    The stability of epigenetic patterns is critical for genome integrity and gene expression. This highly coordinated process involves interrelated positive and negative regulators that impact distinct epigenetic marks, including DNA methylation and dimethylation at histone H3 lysine 9 (H3K9me2). In Arabidopsis, mutations in the DNA methyltransferase MET1, which maintains CG methylation, result in aberrant patterns of other epigenetic marks, including ectopic non-CG methylation and the relocation of H3K9me2 from heterochromatin into gene-rich chromosome regions. Here, we show that the expression of the H3K9 demethylase IBM1 (increase in BONSAI methylation 1) requires DNA methylation. Surprisingly, the regulatory methylated region is contained in an unusually large intron that is conserved in IBM1 orthologues. The re-establishment of IBM1 expression in met1 mutants restored the wild-type H3K9me2 nuclear patterns, non-CG DNA methylation and transcriptional patterns at selected loci, which included DNA demethylase genes. These results provide a mechanistic explanation for long-standing puzzling observations in met1 mutants and reveal yet another layer of control in the interplay between DNA methylation and histone modification, which stabilizes DNA methylation patterns at genes.

  1. The web server of IBM's Bioinformatics and Pattern Discovery group: 2004 update.

    Science.gov (United States)

    Huynh, Tien; Rigoutsos, Isidore

    2004-07-01

    In this report, we provide an update on the services and content which are available on the web server of IBM's Bioinformatics and Pattern Discovery group. The server, which is operational around the clock, provides access to a large number of methods that have been developed and published by the group's members. There is an increasing number of problems that these tools can help tackle; these problems range from the discovery of patterns in streams of events and the computation of multiple sequence alignments, to the discovery of genes in nucleic acid sequences, the identification--directly from sequence--of structural deviations from alpha-helicity and the annotation of amino acid sequences for antimicrobial activity. Additionally, annotations for more than 130 archaeal, bacterial, eukaryotic and viral genomes are now available on-line and can be searched interactively. The tools and code bundles continue to be accessible from http://cbcsrv.watson.ibm.com/Tspd.html whereas the genomics annotations are available at http://cbcsrv.watson.ibm.com/Annotations/.

  2. The web server of IBM's Bioinformatics and Pattern Discovery group: 2004 update

    Science.gov (United States)

    Huynh, Tien; Rigoutsos, Isidore

    2004-01-01

    In this report, we provide an update on the services and content which are available on the web server of IBM's Bioinformatics and Pattern Discovery group. The server, which is operational around the clock, provides access to a large number of methods that have been developed and published by the group's members. There is an increasing number of problems that these tools can help tackle; these problems range from the discovery of patterns in streams of events and the computation of multiple sequence alignments, to the discovery of genes in nucleic acid sequences, the identification—directly from sequence—of structural deviations from α-helicity and the annotation of amino acid sequences for antimicrobial activity. Additionally, annotations for more than 130 archaeal, bacterial, eukaryotic and viral genomes are now available on-line and can be searched interactively. The tools and code bundles continue to be accessible from http://cbcsrv.watson.ibm.com/Tspd.html whereas the genomics annotations are available at http://cbcsrv.watson.ibm.com/Annotations/. PMID:15215340

  3. Production of IL-6 by human myoblasts stimulated with Abeta: relevance in the pathogenesis of IBM.

    Science.gov (United States)

    Baron, P; Galimberti, D; Meda, L; Scarpini, E; Conti, G; Cogiamanian, F; Scarlato, G

    2001-11-13

    To determine whether amyloid-beta protein (Abeta) can induce the production of proinflammatory cytokines by cultured normal muscle cells. Sporadic inclusion body myositis (IBM) is characterized by the presence of rimmed vacuoles and fibrillary inclusions of Abeta in muscle fibers, and often inflammatory cells. Endomysial expression of proinflammatory molecules has suggested an ongoing immune process, but the site of sensitization and the mechanisms that trigger an inflammatory reaction is unknown. The authors used Northern blot analysis and specific immunoassays to study the expression and secretion in cell-free supernatants of tumor necrosis factor-alpha (TNFalpha), interleukin-1beta (IL-1beta), and interleukin-6 (IL-6) by purified human myoblasts and C2C12 mouse skeletal muscle cells incubated with Abeta[1-42] or Abeta[25-35] peptides. Nonstimulated muscle cells produced detectable IL-6, whereas secretion of IL-1beta and TNFalpha was absent. Incubation with Abeta peptides increased IL-6 production, whereas TNFalpha and IL-1beta levels remained undetectable. Northern blot analysis of Abeta-stimulated human myoblasts revealed an increase in IL-6 mRNA expression. Cultured muscle cells increase the constitutive production of IL-6 in response to local deposition of Abeta in sporadic IBM. IL-6 could be a CD8(+) proliferation and differentiation agent, an autocrine proteolysis-inducing factor of damaged myotubes, and a proliferation-stimulating agent for satellite cells to replace the destroyed myofibers in IBM.

  4. IBM BAGI TUTOR PAUD ANAK BANGSA VI KELURAHAN TANDANG SEMARANG

    Directory of Open Access Journals (Sweden)

    Tarcisia Sri Suwarti

    2016-10-01

    Full Text Available Pendidikan anak usia dini (PAUD adalah jenjang pendidikan sebelum jenjang pendidikan dasar yang merupakan suatu upaya pembinaan yang ditujukan bagi anak sejak lahir sampai dengan usia enam tahun agar anak memiliki kesiapan dalam memasuki pendidikan lebih lanjut. Kelurahan Tandang, Semarang memiliki 14 kelompok PAUD yang masing-masing memiliki mayoritas tutor ibu rumah tangga yang kurang memiliki bekal pengetahuan dalam pengelolaan PAUD. Dilihat dari sisi lain, anak-anak usia dini pada era sekarang sedikit banyak telah mengenal berbagai teknologi modern yang mendukung mereka untuk mengenal dunia di sekitarnya termasuk  penggunaan fitur emoticon yang terdapat dalam teknologi modern seperti handphone. Oleh karena itu, untuk mengimbangi  perkembangan  pengetahuan  siswanya,  para  tutor  PAUD  Anak  Bangsa  VI  di Kelurahan Tandang, Semarang perlu dibekali teknik-teknik pengajaran PAUD secara khusus dalam hal  teknik  pengajaran  kosakata  bahasa  kepada  siswa  melalui  media  emoticon  sehingga  bisa menarik minat siswa untuk memperluas kosakata bahasa mereka. Berkenaan dengan hal ini, tim pelaksana  memberikan  pelatihan  berupa  pembekalan  yang  berisi  tentang  teori  dan  teknik pengajaran kosakata bahasa dengan menggunakan media emoticon. Dalam pembekalan tersebut, tim juga menyediakan fasilitas mengajar berupa media gambar emoticon dengan tampilan yang menarik.   Setelah   dilakukan   pelatihan   tersebut,   selanjutnya   peserta   mulai   diajak   untuk mempraktekan teknik mengajar tersebut kepada siswa PAUD yang dibimbingnya. Luaran yang telah dicapai dalam program pengabdian kepada masyarakat ini adalah produk pengabdian berupa emoticon card,   para tutor PAUD dapat memahami teori mengenai teknik pengajaran kosakata bahasa kepada siswa PAUD, para tutor PAUD dapat langsung menerapkan teknik pengajaran kosakata bahasa dengan menggunakan media emoticon kepada siswa didiknya, sehingga para

  5. PC floor systems for microelectronics manufacturing buildings

    Science.gov (United States)

    Hong, Kappyo; Lee, Seongsoo; Kwon, Yunhan; Chun, Homin; Cho, Kwangsu; Kim, Sijun

    2010-03-01

    Because a PC(Precast Concrete) system has to follow the transportation rules for transporting PC units and be designed to the specifications of the tools and equipment on site, designing long-span PC systems for microelectronics manufacturing facilities can be troublesome due to complications in transporting, lifting and handling the PC units. To resolve these problems that can occur in long span and heavy weight PC designs, this study proposes two types of long-span PC floor systems that practically use the traditional Gerber beam concept. In the proposed systems, long-span (17.4m) girders or beams are segmented into appropriate lengths using the Gerber system for easy delivery and lifting. Moreover, these systems provide the ability to optimally design massive units by controlling the location of hinge points. On the other hand, because continuous long-span girders or beams are segmented into the Gerber system's hinge points, these systems may generate structural stability problems during construction. Consequently, this study experimentally examines the structural performance of stress transfer mechanism in panel zones and the construction stability of PC units for columns and girders during assembly.

  6. A PC-based discrete event simulation model of the Civilian Radioactive Waste Management System

    Energy Technology Data Exchange (ETDEWEB)

    Airth, G.L. [Hands-on GPSS Training, Corvallis, OR (United States); Joy, D.S.; Nehls, J.W. [Oak Ridge National Lab., TN (United States)

    1991-12-31

    A System Simulation Model has been developed for the Department of Energy to simulate the movement of individual waste packages (spent fuel assemblies and fuel containers) through the Civilian Radioactive Waste Management System (CRWMS). A discrete event simulation language, GPSS/PC, which runs on an IBM/PC and operates under DOS 5.0, mathematically represents the movement and processing of radioactive waste packages through the CRWMS and the interaction of these packages with the equipment in the various facilities. This model can be used to quantify the impacts of different operating schedules, operational rules, system configurations, and equipment reliability and availability considerations on the performance of processes comprising the CRWMS and how these factors combine to determine overall system performance for the purpose of making system design decisions. The major features of the System Simulation Model are: the ability to reference characteristics of the different types of radioactive waste (age, burnup, etc.) in order to make operational and/or system design decisions, the ability to place stochastic variations on operational parameters such as processing time and equipment outages, and the ability to include a rigorous simulation of the transportation system. Output from the model includes the numbers, types, and characteristics of waste packages at selected points in the CRWMS and the extent to which various resources will be utilized in order to transport, process, and emplace the waste.

  7. LMSS SERVICES FINANCIAL REPORT PROGRAM

    Science.gov (United States)

    Chamberlain, R. G.

    1994-01-01

    The objective of this Services Finance Report program is to provide a means for comparing alternative designs of LMSS systems or other services systems. This program is actually a Multiplan worksheet. The labels used in the worksheet were chosen for a satellite-based cellular communication service (LMSS - Land Mobile Satellite System) but the analysis is not restricted to such cases. A comprehensive financial model is used to calculate a 'figure of merit' which can be used to compare effects of equipment and operating costs, pricing strategy, and customer demand for different systems. The program also calculates the price that a company would have to charge customers to meet all its expenses and make a specified profit. A price estimate can be obtained for almost any service which is heavily dependent on capital investment and which has operating costs that depend on the amount of service sold. The economic analysis has two main components: supplier finances and customer finances. Supplier finances include amortization, interest, insurance, taxes, and operating and maintenance expenses. Customer finances include usage rate, subscription fees, equipment costs, and estimated traffic. Prices can defined as real or nominal to account for effects of escalation and inflation, and the profits can be regulated or unrestricted This program is written for interactive execution with Multiplan (version 1.2) and has been implemented on an IBM PC series computer operating under DOS (version 2.11). The LMSS worksheet has a space requirement of approximately 38K of 8 bit bytes. This worksheet was developed in 1984.

  8. Extensive set of macros for structured programing in OS/360 assembly language (STRCMACS)

    Science.gov (United States)

    Barth, C. W.

    1975-01-01

    Development of consistent assembly language structured programming techniques has been enhanced by use of assembly macros developed for structured programing. Set of macros was written for IBM OS/360 Assembly language.

  9. Do the Pc+ pentaquarks have strange siblings?

    Science.gov (United States)

    Lebed, Richard F.

    2015-12-01

    The recent LHCb discovery of states Pc+(4380 ), Pc+(4450 ), believed to be c c ¯u u d pentaquark resonances, begs the question of whether equivalent states with c c ¯→s s ¯ exist, and how they might be produced. The precise analogue to the Pc+ discovery channel Λb→J /ψ K-p , namely, Λc→ϕ π0p , is feasible for this study and indeed is less Cabibbo suppressed, although its limited phase space suggests that evidence of a s s ¯u u d resonance Ps+ would be confined to the kinematic end-point region.

  10. Metal Detector By Using PIC Microcontroller Interfacing With PC

    Directory of Open Access Journals (Sweden)

    Yin Min Theint

    2015-06-01

    Full Text Available Abstract This system proposes metal detector by using PIC microcontroller interfacing with PC. The system uses PIC microcontroller as the main controller whether the detected metal is ferrous metal or non-ferrous metal. Among various types of metal sensors and various types of metal detecting technologies concentric type induction coil sensor and VLF very low frequency metal detecting technology are used in this system. This system consists of two configurations Hardware configuration and Software configuration. The hardware components include induction coil sensors which senses the frequency changes of metal a PIC microcontroller personal computer PC buzzer light emitting diode LED and webcam. The software configuration includes a program controller interface. PIC MikroCprogramming language is used to implement the control system. This control system is based on the PIC 16F887 microcontroller.This system is mainly used in mining and high security places such as airport plaza shopping mall and governmental buildings.

  11. Linear-Algebra Programs

    Science.gov (United States)

    Lawson, C. L.; Krogh, F. T.; Gold, S. S.; Kincaid, D. R.; Sullivan, J.; Williams, E.; Hanson, R. J.; Haskell, K.; Dongarra, J.; Moler, C. B.

    1982-01-01

    The Basic Linear Algebra Subprograms (BLAS) library is a collection of 38 FORTRAN-callable routines for performing basic operations of numerical linear algebra. BLAS library is portable and efficient source of basic operations for designers of programs involving linear algebriac computations. BLAS library is supplied in portable FORTRAN and Assembler code versions for IBM 370, UNIVAC 1100 and CDC 6000 series computers.

  12. Implementation and Performance Modeling of Deterministic Particle Transport (Sweep3D on the IBM Cell/B.E.

    Directory of Open Access Journals (Sweden)

    Olaf Lubeck

    2009-01-01

    Full Text Available The IBM Cell Broadband Engine (BE is a novel multi-core chip with the potential for the demanding floating point performance that is required for high-fidelity scientific simulations. However, data movement within the chip can be a major challenge to realizing the benefits of the peak floating point rates. In this paper, we present the results of implementing Sweep3D on the Cell/B.E. using an intra-chip message passing model that minimizes data movement. We compare the advantages/disadvantages of this programming model with a previous implementation using a master–worker threading strategy. We apply a previously validated micro-architecture performance model for the application executing on the Cell/B.E. (based on our previous work in Monte Carlo performance models, that predicts overall CPI (cycles per instruction, and gives a detailed breakdown of processor stalls. Finally, we use the micro-architecture model to assess the performance of future design parameters for the Cell/B.E. micro-architecture. The methodologies and results have broader implications that extend to multi-core architectures.

  13. Management and transmission of DICOM files using PC to PC multicasting methodology.

    Science.gov (United States)

    Kim, I K; Kwon, G B; Choi, W K; Cho, H; Kwak, Y S

    2001-01-01

    The PACS system built and used in hospitals nowadays has quite significant overload on its central server because of both treatment of very large data and full management of medical images. We suggest a distributed communication and management methodology using PC to PC multicasting strategy for efficient management of medical images produced by DICOM modalities. It is absolutely necessary for reducing strict degradation of PACS system due to large size of medical images and its very high transport rates. DICOM PC to PC component is composed a service manager to execute requested queries, a communication manager to take charge of file transmission, and a DICOM manager to manage stored data and system behavior. Each manager itself is a component to search for requested file by interaction or transmit the file to other PCs. Distributed management and transformation of medical information based on PC to PC multicasting methodology will enhance performance of central server and network capacity reducing overload on them.

  14. Large program implementation on minicomputers

    CERN Document Server

    Fonti, L

    1980-01-01

    A method is described to fit a very large program (usually executed on very big mainframes, like a CDC 7600 or IBM 370/168) on a 16-bit minicomputer with memory management support. The method outlined is fully general, even if references are made to a specific example: the implementation of the CERN program HYDRA on a PDP 11/70. (2 refs).

  15. A Three-Dimensional Transonic, Potential Flow Computer Program, Its Conversion to IBM Fortran and Utilization

    Science.gov (United States)

    1983-12-01

    8217 «-H co«» omro rococo >r>o inr* uoocMcoo^ooin^rmoooroh-ro^cnp-co^cof-cTtro ^Hv»>Ot-»>>»>j"(oromr^>-isOcoooo^H>f coroooococoofoco OX«,<D<yi^’t|Tl...oooooooooooooooooooooo Om*T rococo cMvom-j-votn HVOOOC^OH oucnr-ficM**" >-i<M>rcM>r<J, oo »r o^co oooo r-st sj- oo ^ vO vj» Is» vO o» m ro...I I I I I I I I I I I I I I I I m fM co o CM »-4 co in -4" CM m r-t co o m r* »* <x> o >!• m o OCO^CMCO>f rOCOCO *00>>TOCM’HfO rH^O^rvOCO co,Mcooco

  16. Department of Defense (DOD) renewables and energy efficiency planning (REEP) program manual

    Energy Technology Data Exchange (ETDEWEB)

    Nemeth, R.J.; Fournier, D.; Debaillie, L.; Edgar, L.; Stroot, P.; Beasley, R.; Edgar, D.; McMillen, L.; Marren, M.

    1995-08-01

    The Renewables and Energy Efficiency Planning (REEP) program was developed at the US Army Construction Engineering Research Laboratories (USACERL). This program allows for the analysis of 78 energy and water conservation opportunities at 239 major DOD installations. REEP uses a series of algorithms in conjunction with installation specific data to estimate the energy and water conservation potential for entire installations. The program provides the energy, financial, pollution, and social benefits of conservation initiatives. The open architecture of the program allows for simple modification of energy and water conservation variables, and installation database values to allow for individualized analysis. The program is essentially a high-level screening tool that can be used to help identify and focus preliminary conservation studies. The REEP program requires an IBM PC or compatible with a 80386 or 80486 microprocessor. It also requires approximately 4 megabytes of disk space and at least 8 megabytes of RAM. The system was developed for a Windows environment and requires Microsoft Windows 3.1{trademark} or higher to run properly.

  17. Diagnostic report acquisition unit for the Mayo/IBM PACS project

    Science.gov (United States)

    Brooks, Everett G.; Rothman, Melvyn L.

    1991-07-01

    The Mayo Clinic and IBM Rochester have jointly developed a picture archive and control system (PACS) for use with Mayo's MRI and Neuro-CT imaging modalities. One of the challenges of developing a useful PACS involves integrating the diagnostic reports with the electronic images so they can be displayed simultaneously. By the time a diagnostic report is generated for a particular case, its images have already been captured and archived by the PACS. To integrate the report with the images, the authors have developed an IBM Personal System/2 computer (PS/2) based diagnostic report acquisition unit (RAU). A typed copy of the report is transmitted via facsimile to the RAU where it is stacked electronically with other reports that have been sent previously but not yet processed. By processing these reports at the RAU, the information they contain is integrated with the image database and a copy of the report is archived electronically on an IBM Application System/400 computer (AS/400). When a user requests a set of images for viewing, the report is automatically integrated with the image data. By using a hot key, the user can toggle on/off the report on the display screen. This report describes process, hardware, and software employed to integrate the diagnostic report information into the PACS, including how the report images are captured, transmitted, and entered into the AS/400 database. Also described is how the archived reports and their associated medical images are located and merged for retrieval and display. The methods used to detect and process error conditions are also discussed.

  18. The study of structure in 224–234 thorium nuclei within the framework IBM

    Directory of Open Access Journals (Sweden)

    Lee Su Youn

    2017-01-01

    Full Text Available An investigation has been made of the behaviour of nuclear structure as a function of an increase in neutron number from 224Th to 234Th. Thorium of mass number 234 is a typical rotor nucleus that can be explained by the SU(3 limit of the interacting boson model(IBM in the algebraic nuclear model. Furthermore, 224−232Th lie on the path of the symmetry-breaking phase transition. Moreover, the nuclear structure of 224Th can be explained using X(5 symmetry. However, as 226−230Th nuclei are not fully symmetrical nuclei, they can be represented by adding a perturbed term to express symmetry breaking. Through the following three calculation steps, we identified the tendency of change in nuclear structure. Firstly, the structure of 232Th is described using the matrix elements of the Hamiltonian and the electric quadrupole operator between basis states of the SU(3 limit in IBM. Secondly, the low-lying energy levels and E2 transition ratios corresponding to the observable physical values are calculated by adding a perturbed term with the first-order Casimir operator of the U(5 limit to the SU(3 Hamiltonian in IBM. We compared the results with experimental data of 224−234Th. Lastly, the potential of the Bohr Hamiltonian is represented by a harmonic oscillator, as a result of which the structure of 224−234Th could be expressed in closed form by an approximate separation of variables. The results of these theoretical predictions clarify nuclear structure changes in Thorium nuclei over mass numbers of practical significance.

  19. The study of structure in 224-234 thorium nuclei within the framework IBM

    Science.gov (United States)

    Lee, Su Youn; Lee, Young Jun; Lee, J. H.

    2017-09-01

    An investigation has been made of the behaviour of nuclear structure as a function of an increase in neutron number from 224Th to 234Th. Thorium of mass number 234 is a typical rotor nucleus that can be explained by the SU(3) limit of the interacting boson model(IBM) in the algebraic nuclear model. Furthermore, 224-232Th lie on the path of the symmetry-breaking phase transition. Moreover, the nuclear structure of 224Th can be explained using X(5) symmetry. However, as 226-230Th nuclei are not fully symmetrical nuclei, they can be represented by adding a perturbed term to express symmetry breaking. Through the following three calculation steps, we identified the tendency of change in nuclear structure. Firstly, the structure of 232Th is described using the matrix elements of the Hamiltonian and the electric quadrupole operator between basis states of the SU(3) limit in IBM. Secondly, the low-lying energy levels and E2 transition ratios corresponding to the observable physical values are calculated by adding a perturbed term with the first-order Casimir operator of the U(5) limit to the SU(3) Hamiltonian in IBM. We compared the results with experimental data of 224-234Th. Lastly, the potential of the Bohr Hamiltonian is represented by a harmonic oscillator, as a result of which the structure of 224-234Th could be expressed in closed form by an approximate separation of variables. The results of these theoretical predictions clarify nuclear structure changes in Thorium nuclei over mass numbers of practical significance.

  20. Operating a Geiger-Muller Tube Using a PC Sound Card

    Science.gov (United States)

    Azooz, A. A.

    2009-01-01

    In this paper, a simple MATLAB-based PC program that enables the computer to function as a replacement for the electronic scalar-counter system associated with a Geiger-Muller (GM) tube is described. The program utilizes the ability of MATLAB to acquire data directly from the computer sound card. The signal from the GM tube is applied to the…

  1. Distributed pC++ Basic Ideas for an Object Parallel Language

    Directory of Open Access Journals (Sweden)

    François Bodin

    1993-01-01

    Full Text Available pC++ is an object-parallel extension to the C++ programming language. This paper describes the current language definition and illustrates the programming style. Exampies of parallel linear algebra operations are presented and a fast Poisson solver is described in complete detail.

  2. Benchmark Tests on the New IBM RISC System/6000 590 Workstation

    Directory of Open Access Journals (Sweden)

    Harvey J. Wasserman

    1995-01-01

    Full Text Available The results of benchmark tests on the superscalar IBM RISC System/6000 Model 590 are presented. A set of well-characterized Fortran benchmarks spanning a range of computational characteristics was used for the study. The data from the 590 system are compared with those from a single-processor CRAY C90 system as well as with other microprocessor-based systems, such as the Digital Equipment Corporation AXP 3000/500X and the Hewlett-Packard HP/735.

  3. X-linked Emery-Dreifuss muscular dystrophy with lamin A deficiency and IBM inclusions.

    Science.gov (United States)

    Fidzianska, A; Niebrój-Dobosz, I; Madej-Pilarczyk, A; Duong, N T; Wehnert, M

    2010-01-01

    The study demonstrates a 12-year-old patient with progressive proximal muscle weakness, joint contractures, rigidity of the neck, and absence of emerin and lamin A in the muscle nuclei, which is caused by intronic mutation IVS3-27del18 (c.266-27del18) in the emerin gene. The most surprising finding was the appearance of IBM-like inclusions in euchromatin, as well as aberrant nuclei. It may be speculated that altered expression of the emerin-lamin complex and modification of the nuclear matrix leads to formation of tubulofilamentous structures in the presented case.

  4. COMPPAP - COMPOSITE PLATE BUCKLING ANALYSIS PROGRAM (UNIX VERSION)

    Science.gov (United States)

    Smith, J. P.

    1994-01-01

    The Composite Plate Buckling Analysis Program (COMPPAP) was written to help engineers determine buckling loads of orthotropic (or isotropic) irregularly shaped plates without requiring hand calculations from design curves or extensive finite element modeling. COMPPAP is a one element finite element program that utilizes high-order displacement functions. The high order of the displacement functions enables the user to produce results more accurate than traditional h-finite elements. This program uses these high-order displacement functions to perform a plane stress analysis of a general plate followed by a buckling calculation based on the stresses found in the plane stress solution. The current version assumes a flat plate (constant thickness) subject to a constant edge load (normal or shear) on one or more edges. COMPPAP uses the power method to find the eigenvalues of the buckling problem. The power method provides an efficient solution when only one eigenvalue is desired. Once the eigenvalue is found, the eigenvector, which corresponds to the plate buckling mode shape, results as a by-product. A positive feature of the power method is that the dominant eigenvalue is the first found, which is this case is the plate buckling load. The reported eigenvalue expresses a load factor to induce plate buckling. COMPPAP is written in ANSI FORTRAN 77. Two machine versions are available from COSMIC: a PC version (MSC-22428), which is for IBM PC 386 series and higher computers and compatibles running MS-DOS; and a UNIX version (MSC-22286). The distribution medium for both machine versions includes source code for both single and double precision versions of COMPPAP. The PC version includes source code which has been optimized for implementation within DOS memory constraints as well as sample executables for both the single and double precision versions of COMPPAP. The double precision versions of COMPPAP have been successfully implemented on an IBM PC 386 compatible running

  5. PC interfacing using Centronics, RS232 and game ports

    CERN Document Server

    An, Pei

    1998-01-01

    The main links with your PC and the outside world are the centronic port, used for connecting the printer, the RS232 port, used for the mouse, and the games port for a joystick. This book explores how these input/output (I/O) ports can be put to use through a range of other interfacing applications. This is especially useful for laptop and palmtop PCs which cannot be fitted with internal I/O cards. A novel approach is taken by this book, combining the hardware through which the ports can be explored, and the software programming needed to carry out a range of experiments.Circuits are p

  6. Training HBCU Faculty and Students in Prostate Cancer (PC) Research: Signal Transduction and Receptor-Inhibitor Interactions in the Progress of PC

    National Research Council Canada - National Science Library

    Wiese, Thomas E; Klassen, R. B

    2008-01-01

    .... One new project has been developed and is involving students. (3) To establish a long-term collaborative relationship between Xavier University and the TCC in PC research. XU faculty in the program are now members of the Tulane Cancer Center and involved in weekly seminars and focus group meetings.

  7. Training HBCU Faculty and Students in Prostate Cancer (PC) Research: Signal Transduction and Receptor-Inhibitor Interactions in the Progress of PC

    National Research Council Canada - National Science Library

    Wiese, Thomas E; Klassen, R. B

    2007-01-01

    .... One new project has been developed and is involving students. (3) To establish a long-term collaborative relationship between Xavier University and the TCC in PC research. XU faculty in the program are now members of the Tulane Cancer Center and involved in weekly seminars and focus group meetings.

  8. A PC based seismic data transcription system

    Energy Technology Data Exchange (ETDEWEB)

    Suh, Sang Yong; Chung, Bu Heung; Jang, Seong Hyung [Korea Institute of Geology Mining and Materials, Taejon (Korea, Republic of)

    1997-12-01

    Old seismic data recorded on magnetic tapes is often difficult to read because of the tape sticking problem known as the `sticky syndrome`. It has to be transcribed to other suitable media using dedicated multiple systems during the whole project years. The first system requirement is the capability of reading gapless magnetic tape, which is peculiar to the old seismic data tapes. The second requirement would be the availability of storage devices with compact and huge capacity. The system must be cheap enough compared to the total cost of the data being transcribed. We introduce a PC based seismic data transcribing system. The system is equipped with an tape drive which can handle 800, 1600, 3200, and 6250 BPI densities. Well known storage devices such as 8mm Exabyte, 4mm DDS-2, and the SCSI CD recorder, are selected for the output devices. These output media should provide more durability, compactness, and portability than the original. Linux is chosen for the operating system. Unfortunately, the Linux, like other Unix systems, is subject to the limit in maximum i/o block size. The maximum block size of the SCSI tape driver is fixed to 32 KB, which is far less than the requirements in SEG-A, B, and C seismic tapes. A kernel patch is written to extend such a limit up to 2048 KB. Input and output programs are written to handle the tape data in variable block mode. A unique disk file format is designed to preserve the IBG(inter-block gap) within the disk copy. A utility program is also provided to manipulate the disk copy and to convert to SU(Seismic Unix) compatible SEG-Y file. Of the total two months of the transcription period, we spend most of the time in reading the sticky magnetic tapes. The seismic tapes had to be `baked` to dry out the moisture before reading. It took nine days to burn the all 85 diskettes. Writing two sets of 8mm Exabytes took only one day. It is considered that 8mm Exabyte can be the optimum output media for the main seismic data storage

  9. Peak Pc Prediction in Conjunction Analysis: Conjunction Assessment Risk Analysis. Pc Behavior Prediction Models

    Science.gov (United States)

    Vallejo, J.J.; Hejduk, M.D.; Stamey, J. D.

    2015-01-01

    Satellite conjunction risk typically evaluated through the probability of collision (Pc). Considers both conjunction geometry and uncertainties in both state estimates. Conjunction events initially discovered through Joint Space Operations Center (JSpOC) screenings, usually seven days before Time of Closest Approach (TCA). However, JSpOC continues to track objects and issue conjunction updates. Changes in state estimate and reduced propagation time cause Pc to change as event develops. These changes a combination of potentially predictable development and unpredictable changes in state estimate covariance. Operationally useful datum: the peak Pc. If it can reasonably be inferred that the peak Pc value has passed, then risk assessment can be conducted against this peak value. If this value is below remediation level, then event intensity can be relaxed. Can the peak Pc location be reasonably predicted?

  10. Arabidopsis EDM2 promotes IBM1 distal polyadenylation and regulates genome DNA methylation patterns.

    Science.gov (United States)

    Lei, Mingguang; La, Honggui; Lu, Kun; Wang, Pengcheng; Miki, Daisuke; Ren, Zhizhong; Duan, Cheng-Guo; Wang, Xingang; Tang, Kai; Zeng, Liang; Yang, Lan; Zhang, Heng; Nie, Wenfeng; Liu, Pan; Zhou, Jianping; Liu, Renyi; Zhong, Yingli; Liu, Dong; Zhu, Jian-Kang

    2014-01-07

    DNA methylation is important for the silencing of transposons and other repetitive elements in many higher eukaryotes. However, plant and mammalian genomes have evolved to contain repetitive elements near or inside their genes. How these genes are kept from being silenced by DNA methylation is not well understood. A forward genetics screen led to the identification of the putative chromatin regulator Enhanced Downy Mildew 2 (EDM2) as a cellular antisilencing factor and regulator of genome DNA methylation patterns. EDM2 contains a composite Plant Homeo Domain that recognizes both active and repressive histone methylation marks at the intronic repeat elements in genes such as the Histone 3 lysine 9 demethylase gene Increase in BONSAI Methylation 1 (IBM1) and is necessary for maintaining the expression of these genes by promoting mRNA distal polyadenylation. Because of its role in maintaining IBM1 expression, EDM2 is required for preventing CHG methylation in the bodies of thousands of genes. Our results thus increase the understanding of antisilencing, genome methylation patterns, and regulation of alternative RNA processing by intronic heterochromatin.

  11. New coupling limits, dynamical symmetries and microscopic operators of IBM/TQM

    Science.gov (United States)

    Paar, V.

    1985-01-01

    A new particle-core basis having approximate supersymmetric (SUSY) features associated with SU(3) dynamical symmetry is introduced. The SUSY and CO-SUSY limits of IBFM/PTQM appear for the characteristic intermediate coupling strengths Γ/δ=±(Γ/δ)SUSY. The CO-SUSY limit is a truncated analog of the Stephens rotation-aligned scheme. A paradox was found in the relation of the SUSY and truncated strong coupling (TSC) limits to the strong coupling limit of the Bohr-Mottelson model. Microscopic dyson and Holstein-Primakoff realizations of RPA collective quadrupole phonon operators are explicitly constructed. Employing this mapping procedure in conjunction with the leading RPA diagrams, various operators of IBM/TQM, IBFM/PTQM have been derived in the particle-hole channel: E2 operator, one-particle transfer operator, two-particle transfer operator etc. In addition to the standard terms, this derivation gives in the same diagrammatic order the additional terms also. A new model was introduced for the odd-odd nuclei in the framework of IBM/TQM. For the SU(3) core the truncated analog of Gallagher-Moszkowski bands appears as the approximate SUSY pattern, of the same intrinsic structure as in the odd-even system. The idea of boson-fermion dynamical symmetry and supersymmetry is extended to odd-odd nuclei and hypernuclei.

  12. Influence of wall motion on particle sedimentation using hybrid LB-IBM scheme

    Science.gov (United States)

    Habte, Mussie A.; Wu, ChuiJie

    2017-03-01

    We integrate the lattice Boltzmann method (LBM) and immersed boundary method (IBM) to capture the coupling between a rigid boundary surface and the hydrodynamic response of an enclosed particle laden fluid. We focus on a rigid box filled with a Newtonian fluid where the drag force based on the slip velocity at the wall and settling particles induces the interaction. We impose an external harmonic oscillation on the system boundary and found interesting results in the sedimentation behavior. Our results reveal that the sedimentation and particle locations are sensitive to the boundary walls oscillation amplitude and the subsequent changes on the enclosed flow field. Two different particle distribution analyses were performed and showed the presence of an agglomerate structure of particles. Despite the increase in the amplitude of wall motion, the turbulence level of the flow field and distribution of particles are found to be less in quantity compared to the stationary walls. The integrated LBM-IBM methodology promised the prospect of an efficient and accurate dynamic coupling between a non-compliant bounding surface and flow field in a wide-range of systems. Understanding the dynamics of the fluid-filled box can be particularly important in a simulation of particle deposition within biological systems and other engineering applications.

  13. Quantitative trait loci mapping of metal concentrations in leaves of the maize IBM population.

    Science.gov (United States)

    Zdunić, Zvonimir; Grljušić, Sonja; Ledenčan, Tatjana; Duvnjak, Tomislav; Simić, Domagoj

    2014-06-01

    Characterizing concentrations of several beneficiary and toxic metals in maize leaves is of importance for ionomic studies and for silage production. The intermated B73 × Mo17 maize population (IBM) was evaluated for concentrations of eight metals (cadmium - Cd, copper - Cu, iron - Fe, potassium - K, magnesium - Mg, manganese - Mn, strontium - Sr and zinc - Zn) in ear-leaf to map quantitative trait loci (QTL) with 2161 molecular markers across the genome. QTL analysis revealed nine significant QTLs for concentrations of Cd, Cu, Fe, K, Mg and Sr combined over two environments. Median resolution for the QTL interval was less than 1 cM on a regular F2 map, which is a big improvement compared with the prior mapping (8 cM). The highest LOD scores of 15.52 and 15.31 were detected for K and Cd concentrations, respectively, explaining more than 20 percent of the phenotypic variance. No QTLs were found to be colocalized. QTL mapping in the IBM population did not confirm our earlier QTL results demonstrating considerable QTL ×genetic background interaction. The only exception is confirmation of the major QTL for Cd accumulation on chromosome 2. Our results could facilitate further genetic and physical mapping of genes for metal accumulation in maize. © 2014 The Authors.

  14. IbM PENYUSUNAN PENILAIAN AUTENTIK BAGI GURU SEKOLAH DI PONPES DARUL FIKRI BAWEN

    Directory of Open Access Journals (Sweden)

    Joko Siswanto

    2015-09-01

    Full Text Available Abstract Low motivation of teachers in implementing authentic assessment becomes the basis for IbM team to carry out extension activities. Authentic assessment has actually been around a long time, but this issue arose when the curriculum was launched in 2013. During this time, most of the teachers at school in the field only make an assessment test course, not many people touched assessment tests that are written. Through activities of IbM Authentic Assessment Preparation Training for Teachers of Pesantren Darul Fikri Bawen, participants are expected to conduct a written assessment, performance assessment, product assessment projects, portfolio assessment, and manage the mark using computer-based process. Prior to socialization, teachers must first take pretest and post test. Pre test shows an average score of 89.65 while the average of post-test scores shows 97.6. During the activities, the participants felt helped and gave a positive response to organized similar activities. Keywords: Preparation, Assessment Authentic, Darul Fikri Boarding School Teacher

  15. DVD player for the PC environment

    Science.gov (United States)

    Horne, Caspar; Bheda, Hemant; Srivinasan, Partha

    1998-10-01

    The DVD read-only disk provides high quality storage of audio visual contents, and is especially suitable for the storage of movie contents. Stand-alone consumer playback devices are already available on the market, and wide-spread use of DVD ROM is expected for the PC market, as PC peripheral. In the PC environment, the majority of MPEG1 based layers, such as Video CD players, are software players. Performance of such players is indistinguishable from hardware-based players. However, DVD player that using software only remains a challenging task. To tackle this problem we will describe a DVD player that is based on a new architecture, that allows high quality playback of DVD material. The architecture allows software only playback, as well as hardware assisted DVD playback, while adding little to the total system cost.

  16. Tablet PC Support of Students' Learning Styles

    Directory of Open Access Journals (Sweden)

    Shreya Kothaneth

    2012-12-01

    Full Text Available In the context of rapid technology development, it comes as no surprise that technology continues to impact the educational domain, challenging traditional teaching and learning styles. This study focuses on how students with different learning styles use instructional technology, and in particular, the tablet PC, to enhance their learning experience. The VARK model was chosen as our theoretical framework as we analyzed responses of an online survey, both from a quantitative and qualitative standpoint. Results indicate that if used correctly, the tablet PC can be used across different learning styles to enrich the educational experience.

  17. Scalable rendering on PC clusters

    Energy Technology Data Exchange (ETDEWEB)

    WYLIE,BRIAN N.; LEWIS,VASILY; SHIRLEY,DAVID NOYES; PAVLAKOS,CONSTANTINE

    2000-04-25

    This case study presents initial results from research targeted at the development of cost-effective scalable visualization and rendering technologies. The implementations of two 3D graphics libraries based on the popular sort-last and sort-middle parallel rendering techniques are discussed. An important goal of these implementations is to provide scalable rendering capability for extremely large datasets (>> 5 million polygons). Applications can use these libraries for either run-time visualization, by linking to an existing parallel simulation, or for traditional post-processing by linking to an interactive display program. The use of parallel, hardware-accelerated rendering on commodity hardware is leveraged to achieve high performance. Current performance results show that, using current hardware (a small 16-node cluster), they can utilize up to 85% of the aggregate graphics performance and achieve rendering rates in excess of 20 million polygons/second using OpenGL{reg_sign} with lighting, Gouraud shading, and individually specified triangles (not t-stripped).

  18. Digitally-controlled PC-interfaced Boost Converter for Educational Purposes

    DEFF Research Database (Denmark)

    Ljusev, Petar; Andersen, Michael A. E.

    2004-01-01

    This paper describes implementation of a simple digital PID control algorithm for a boost converter using a cheap fixed-point 8-bit microcontroller. Serial communication to a PC server program is established for easier downloading of compensator parameters and current and voltage waveform...... acquisition. At the end, client program is presented which uses TCP/IP connection for operating the digitally controlled boost converter over Internet. The aim of this cheap and flexible PC-interfaced boost converter bench is predominantly educational, to allow students to synthesize different digital...

  19. Determination of the zero in the Two theta angle and the wavelength in the neutron diffractometer for the Cyber computer of the ININ and for the IBM compatible microcomputers; Determinacion del cero en el angulo Dos teta y la longitud de onda en el difractometro de neutrones para la computadora Cyber del ININ y para microcomputadoras compatibles con IBM

    Energy Technology Data Exchange (ETDEWEB)

    Macias B, L.R

    1991-05-15

    The objective of this work consists on determining the calibration in the angular parameters and the neutron wavelength used in the neutron diffractometer of the TRIGA Mark III reactor, through some readings in that a well-known sample is used by means of a Fortran computer program that is used in the CYBER computer of the ININ in Mexico, and/or in micro computers compatible with IBM. The program was also designed to determine the zero of the 2 {theta} angle of the goniometer of the diffractometer. The generated data were proven by means of well-known data of the Powder Diffraction File of the Joint Committee on Powder Diffraction Standards (JCPDS). (Author)

  20. A PC based thin film dosimeter system

    DEFF Research Database (Denmark)

    Miller, A.; Hargittai, P.; Kovacs, A.

    2000-01-01

    A dosimeter system based on the Riso B3 dosimeter film, an office scanner for use with PC and the associated software is presented. The scanned image is analyzed either with standard software (Paint Shop Pro 5 or Excel) functions or with the computer code "Scanalizer" that allows presentation...

  1. An Automation Interface for Kappa PC

    DEFF Research Database (Denmark)

    Hartvig, Susanne C

    1999-01-01

    The reports documents an automation interface for Kappa PC. The automation interface can be used to embed Kappa applications in 32-bit Windowsapplications.The interface includes functions for initialising Kappa, for loading an application, for settingvalues, for getting values, and for stopping...

  2. Brugervejledning til pc-programmet STLRAMME

    DEFF Research Database (Denmark)

    Buhelt, M.

    Pc-programmet STLRAMME supplerer SBI-anvisning 187, 'Simple stålrammebygninger. Dimensionering og udførelse'. Programmet kan anvendes til dimensionering af stålrammebygninger med andre mål end dem, der er medtaget i anvisningens tabeller; men det erstatter kun stålramme- og åsetabellerne, ikke an...

  3. PC-1D installation manual and user's guide

    Energy Technology Data Exchange (ETDEWEB)

    Basore, P.A.

    1991-05-01

    PC-1D is a software package for personal computers that uses finite-element analysis to solve the fully-coupled two-carrier semiconductor transport equations in one dimension. This program is particularly useful for analyzing the performance of optoelectronic devices such as solar cells, but can be applied to any bipolar device whose carrier flows are primarily one-dimensional. This User's Guide provides the information necessary to install PC-1D, define a problem for solution, solve the problem, and examine the results. Example problems are presented which illustrate these steps. The physical models and numerical methods utilized are presented in detail. This document supports version 3.1 of PC-1D, which incorporates faster numerical algorithms with better convergence properties than previous versions of the program. 51 refs., 17 figs., 5 tabs.

  4. OpenZika: An IBM World Community Grid Project to Accelerate Zika Virus Drug Discovery.

    Directory of Open Access Journals (Sweden)

    Sean Ekins

    2016-10-01

    Full Text Available The Zika virus outbreak in the Americas has caused global concern. To help accelerate this fight against Zika, we launched the OpenZika project. OpenZika is an IBM World Community Grid Project that uses distributed computing on millions of computers and Android devices to run docking experiments, in order to dock tens of millions of drug-like compounds against crystal structures and homology models of Zika proteins (and other related flavivirus targets. This will enable the identification of new candidates that can then be tested in vitro, to advance the discovery and development of new antiviral drugs against the Zika virus. The docking data is being made openly accessible so that all members of the global research community can use it to further advance drug discovery studies against Zika and other related flaviviruses.

  5. OpenZika: An IBM World Community Grid Project to Accelerate Zika Virus Drug Discovery.

    Science.gov (United States)

    Ekins, Sean; Perryman, Alexander L; Horta Andrade, Carolina

    2016-10-01

    The Zika virus outbreak in the Americas has caused global concern. To help accelerate this fight against Zika, we launched the OpenZika project. OpenZika is an IBM World Community Grid Project that uses distributed computing on millions of computers and Android devices to run docking experiments, in order to dock tens of millions of drug-like compounds against crystal structures and homology models of Zika proteins (and other related flavivirus targets). This will enable the identification of new candidates that can then be tested in vitro, to advance the discovery and development of new antiviral drugs against the Zika virus. The docking data is being made openly accessible so that all members of the global research community can use it to further advance drug discovery studies against Zika and other related flaviviruses.

  6. Numerical simulation of 'X-wing' type biplane flapping wings in 3D using the Immersed Boundary Method (IBM)

    NARCIS (Netherlands)

    Tay, W.B.; Van Oudheusden, B.W.; Bijl, H.

    2013-01-01

    The numerical simulation of a “X-wing” type biplane flapping wings, has been performed in 3D using the Immersed Boundary Method (IBM). This “X-wing” type flapping configuration draws its inspiration from Delfly [1], a family of ornithopters developed by the Delft University of Technology, as shown

  7. Position paper on the potential and scope of collaboration between IBM - Big Green Innovations and the climate and water communities

    NARCIS (Netherlands)

    Loon, van A.F.; Lanen, van H.A.J.; Vellinga, P.

    2007-01-01

    A major concern for companies and governments is the robustness of their activities and investments in view of a changing climate. The water sector is in need of technological innovations to be able to cope with the effects of changing climate on the water system. IBM is searching for a way to

  8. PC12 differentiation on biopolymer nanostructures

    Science.gov (United States)

    Cecchini, Marco; Bumma, Giorgia; Serresi, Michela; Beltram, Fabio

    2007-12-01

    The study of nervous system regeneration and axonal outgrowth control are relevant in several research areas, like neurophysiology or biomedical engineering. Among the elements that control neuron dynamics, the host substrate topography is a key parameter in determining cell differentiation. We present time-lapse experiments to analyze the differentiation dynamics of PC12 cells on nanopatterned biocompatible substrates. 200 nm depth gratings were fabricated on tissue-culture polystyrene substrates by nanoimprint lithography; different linewidths and pitches were compared down to 500 nm and 1000 nm, respectively. PC12 cells were cultured on these substrates and, following NGF administration to the medium, body morphology, cell movement and neuritogenesis were monitored at different time periods. In addition to demonstrating guided differentiation, our studies show complex time variations in body morphology and axon length, and guided cell movement. We show unstable synaptic connections and cell-body polarization, and the competition between topographical guidance and cell-cell interactions.

  9. PC12 polarity on biopolymer nanogratings

    Energy Technology Data Exchange (ETDEWEB)

    Cecchini, M; Ferrari, A; Beltram, F [Scuola Normale Superiore and NEST-CNR-INFM, Pisa (Italy); Scuola Normale Superiore and Italian Institute of Technology, Pisa (Italy)], E-mail: m.cecchini@sns.it

    2008-03-15

    Cell differentiation properties are strongly entangled with the morphology and physical properties of the extracellular environment. A complete understanding of this interaction needs artificial scaffolds with controlled nano-/micro-topography. We induced specific topographies by nanoimprint lithography (NIL) on tissue culture polystyrene (TCPS) dishes substrates and, using light microscopy and high-magnification scanning-electron-microscopy, quantitatively compared the changes in PC12 differentiation phenotype induced by the periodicity of the nanopatterns. This analysis revealed that nanogratings reduce the number of neurites produced by PC12 cells upon treatment with NGF and that neuronal bipolarity correlated with an increased stretching of the cell body and a reduced length of the cell neuronal protrusions.

  10. Pc3 pulsations during variable IMF conditions

    Directory of Open Access Journals (Sweden)

    U. Villante

    1999-04-01

    Full Text Available Pc3 geomagnetic field fluctuations detected at low latitude (L'Aquila, Italy during the passage of a high velocity solar wind stream, characterized by variable interplanetary magnetic field conditions, are analyzed. Higher frequency resonant fluctuations and lower frequency phenomena are simultaneously observed; the intermittent appearance and the variable frequency of the longer period modes can be well interpreted in terms of the variable IMF elements; moreover their polarization characteristics are consistent with an origin related to external waves propagating in antisunward direction. A comparison with simultaneous observations performed at Terra Nova Bay (Antarctica provides additional evidence for a clear relationship between the IMF and Pc3 pulsations also at very high latitudes.Key words. Magnetospheric physics (MHD waves and instabilities; solar wind · magnetosphere interactions

  11. Pc3 pulsations during variable IMF conditions

    Directory of Open Access Journals (Sweden)

    U. Villante

    Full Text Available Pc3 geomagnetic field fluctuations detected at low latitude (L'Aquila, Italy during the passage of a high velocity solar wind stream, characterized by variable interplanetary magnetic field conditions, are analyzed. Higher frequency resonant fluctuations and lower frequency phenomena are simultaneously observed; the intermittent appearance and the variable frequency of the longer period modes can be well interpreted in terms of the variable IMF elements; moreover their polarization characteristics are consistent with an origin related to external waves propagating in antisunward direction. A comparison with simultaneous observations performed at Terra Nova Bay (Antarctica provides additional evidence for a clear relationship between the IMF and Pc3 pulsations also at very high latitudes.

    Key words. Magnetospheric physics (MHD waves and instabilities; solar wind · magnetosphere interactions

  12. PC Based wireless stepper motor control

    OpenAIRE

    Jamal, Omar; Khan, Shahnawaz; Abideen, Zainul

    2013-01-01

    This project is about making an embedded system in order to control different functionalities of a stepper motor. The main functions of this stepper motor are to control the speed and direction. The whole hardware consists of two parts. One is the transmitter side and the other side is the receiver side. The transmitter side consists of PC, Encoder, a microcontroller and RF (Radio Frequency) transmitter. On the receiver side there is an RF receiver, a decoder, a microcontroller, a motor drive...

  13. Data of evolutionary structure change: 1A54A-1PC3B [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1A54A-1PC3B 1A54 1PC3 A B --------EASLTGAGATFPAPVYAKWADTYQKET-GNK...Chain> 1PC3 B 1PC3...CA 355 LEU CA 306 GLY CA 308 GLY CA 333 1PC3... B 1PC3B TVDFPAVP...ne> ALA CA 404 ASN CA 326 1PC3

  14. Outsourcing e geração de valor na indústria de computadores pessoais (PCs: estudo de múltiplos casos The disruption of the Brazilian Personal Computer (PC industry: a multiple case study

    Directory of Open Access Journals (Sweden)

    Fernando José Barbin Laurindo

    2003-12-01

    Full Text Available Apesar de o conceito de computador pessoal (personal computer - PC ter surgido nos anos 70, essa indústria realmente deslanchou somente após o lançamento do IBM PC, em 1981. Por meio de uma agressiva estratégia de outsourcing, a IBM rapidamente conquistou o mercado, mas esta estratégia também causou perda de competências internas para seus principais parceiros, Intel e Microsoft, bem como outros revendedores autônomos. No Brasil, atualmente, a indústria de PCs está relegada à montagem de kits importados e também à manufatura das etapas finais do processo de produção de componentes, com pouco valor agregado localmente. Após o término da reserva de mercado, marcado pela súbita abertura aos concorrentes externos, houve desmantelamento da indústria brasileira de PCs e de semicondutores, nos elos de maior valor agregado dessa cadeia. Para obter inserção nas cadeias globais, as empresas brasileiras precisam atingir qualificação nos critérios de desempenho, a fim de participar dos processos de outsourcing. Este artigo visa, por meio de um aparato teórico que relaciona aspectos de outsourcing, inovação, valor e evolução da indústria de PCs, a investigar os impactos desses aspectos na competitividade da indústria de PCs do Brasil e as repercussões para seu crescimento e inserção no mercado global. A abordagem metodológica adotada foi estudo de múltiplos casos, com os seguintes critérios de seleção: diferentes papéis na cadeia de valor, grau de verticalização, principal mercado visado e tamanho da empresa.Although the personal computer (PC appeared in the seventies, this industry really boomed only after IBM launched its PC, in 1981. Through an aggressive outsourcing strategy, IBM rapidly conquered the market, but this strategy also caused lost of internal competences to its main partners, Intel and Microsoft and also to autonomous vendors. Many PC manufacturers have appeared since then. In Brazil, nowadays, PC

  15. Guest Foreword by Lord Phillips KG PC

    Directory of Open Access Journals (Sweden)

    Nicholas A. Phillips

    2012-04-01

    Full Text Available The Rt Hon The Lord Phillips of Worth Matravers KG PC, President of the Supreme Court of the United Kingdom of Great Britain and Northern Ireland Ambition and excellence. Those two words epitomize Qatar. Under the leadership of his Highness the Emir, this small State has set out to make an impact on the world that belies its size. Ambitious was the plan to have an international broadcasting station. Ambitious was the plan to build from scratch a Museum of Islamic Art. Ambitious was the bid – the successful bid to host the World Cup in 2022. Ambitious is the bid to stage the Olympic Games in 2020. Qatar not merely has ambitions, it realizes its ambitions. And when it does so it is not enough to say that the result is ‘world class’, for Qatar sets out to be a world leader in whatever it puts its hand to. Excellence is the norm. Al Jazeera has established itself as the broadcasting station of choice for many throughout the world. The Doha Museum of Islamic Art is recognized as being second to none. In addition, the scale and standard of development in Doha itself is setting new standards of excellence in the fields of architecture and civil engineering. Thus when Qatar focuses its energies on education and the law, high achievements are expected. I shall have the honour of helping to achieve those expectations when I succeed Lord Woolf as President of Qatar’s new and impressive Civil and Commercial Court. The College of Law at Qatar University is already achieving excellence in the field of legal education. So, naturally, all expect great things of this new International Review of Law and I am delighted to have been invited to welcome it by this foreword. The range of the first edition is both international and topical. Those countries that have experienced the turbulence of the Arab Spring are settling new constitutions, and other countries are bent on constitutional reform designed to avoid such turbulence. So an erudite article on

  16. BUFCALC: A Program for the Calculation of Buffers of Specified pH, Ionic Strength, and Buffer Capacity.

    Science.gov (United States)

    Lambert, William J.

    1990-01-01

    Reviewed is a computer software package for IBM personal computers. The theoretical background and functions including several examples are discussed. The algorithm used in computation by the program is given. (CW)

  17. CASKS (Computer Analysis of Storage casKS): A microcomputer based analysis system for storage cask design review. User`s manual to Version 1b (including program reference)

    Energy Technology Data Exchange (ETDEWEB)

    Chen, T.F.; Gerhard, M.A.; Trummer, D.J.; Johnson, G.L.; Mok, G.C. [Lawrence Livermore National Lab., CA (United States)

    1995-02-01

    CASKS (Computer Analysis of Storage casKS) is a microcomputer-based system of computer programs and databases developed at the Lawrence Livermore National Laboratory (LLNL) for evaluating safety analysis reports on spent-fuel storage casks. The bulk of the complete program and this user`s manual are based upon the SCANS (Shipping Cask ANalysis System) program previously developed at LLNL. A number of enhancements and improvements were added to the original SCANS program to meet requirements unique to storage casks. CASKS is an easy-to-use system that calculates global response of storage casks to impact loads, pressure loads and thermal conditions. This provides reviewers with a tool for an independent check on analyses submitted by licensees. CASKS is based on microcomputers compatible with the IBM-PC family of computers. The system is composed of a series of menus, input programs, cask analysis programs, and output display programs. All data is entered through fill-in-the-blank input screens that contain descriptive data requests.

  18. Synthesis of high-purity phthalocyanines (pc): High intrinsic conductivities in the molecular conductors H[sub 2](pc)I and Ni(pc)I

    Energy Technology Data Exchange (ETDEWEB)

    Thompson, J.A.; Murata, K.; Miller, D.C.; Stanton, J.L.; Broderick, W.E.; Hoffman, B.M.; Ibers, J.A. (Northwestern Univ., Evanston, IL (United States))

    1993-08-04

    The authors show that one can prepare M(pc)I crystals, M = [open quotes]H[sub 2][close quotes] and Ni, with remarkably improved charge-transport properties by carefully avoiding impurities in the preparation of the M(pc) precursors. The purest H[sub 2](pc) (<60 ppm free-radical impurities) was prepared by a melt method in quartz and Teflon vessels while very pure Ni(pc) (170-250 pm) could only be obtained by metalation of the pure H[sub 2](pc). Template syntheses of Ni(pc) result in impure material and are to be discouraged for applications requiring very pure M(pc) materials. H[sub 2](pc)I and Ni(pc)I synthesized from the high-purity precursors remain metallic down to ca. 3 K, a far lower temperature than ever before observed. At this temperature the conductivities exhibit maximum values that are ca. 30-fold greater than at room temperature, not 5-7-fold as seen before, with absolute values of [sigma] [approximately] (1-2) [times] 10[sup 4] [Omega][sup [minus]1] cm[sup [minus]1]. The study of a series of Ni(pc)I compounds prepared from Ni(pc) parent materials exhibiting a range of purity levels further shows a strong correlation between the charge-transport properties and the level of paramagnetic impurities in the macrocycle precursor. However, the maximum conductivity appears to saturate at the lowest impurity concentrations, which suggests that the behavior exhibited by the best materials prepared are representative for the first time of the limiting, intrinsic charge-transport properties of H[sub 2](pc)I and Ni(pc)I. A full structure report for H[sub 2](pc)I-1 is presented also. The structure consists of metal-over-metal stacks of partially oxidized H[sub 2](pc) groups surrounded by linear chains of triiodide anions. H[sub 2](pc)I crystallizes with two formula units in the tetragonal space group D[sub 4h][sup 2]-P4/mcc with a = 13.931 [angstrom], c = 6.411 [angstrom], and V = 1244.2 [angstrom][sup 3] (T = 108 K).

  19. Personal Computer-less (PC-less) Microcontroller Training Kit

    Science.gov (United States)

    Somantri, Y.; Wahyudin, D.; Fushilat, I.

    2018-02-01

    The need of microcontroller training kit is necessary for practical work of students of electrical engineering education. However, to use available training kit not only costly but also does not meet the need of laboratory requirements. An affordable and portable microcontroller kit could answer such problem. This paper explains the design and development of Personal Computer Less (PC-Less) Microcontroller Training Kit. It was developed based on Lattepanda processor and Arduino microcontroller as target. The training kit equipped with advanced input-output interfaces that adopted the concept of low cost and low power system. The preliminary usability testing proved this device can be used as a tool for microcontroller programming and industrial automation training. By adopting the concept of portability, the device could be operated in the rural area which electricity and computer infrastructure are limited. Furthermore, the training kit is suitable for student of electrical engineering student from university and vocational high school.

  20. PC-based car license plate reader

    Science.gov (United States)

    Hwang, Chung-Mu; Shu, Shyh-Yeong; Chen, Wen-Yu; Chen, Yie-Wern; Wen, Kuang-Pu

    1992-11-01

    A car license plate reader (CLPR) using fuzzy inference and neural network algorithm has been developed in Industrial Technology Research Institute (ITRI) and installed in highway toll stations to identify stolen cars. It takes an average of 0.7 seconds to recognize a car license plate by using a PC with 80486-50 CPU. The recognition rate of the system is about 97%. The techniques of CLPR include vehicle sensing, image grab control, optic pre- processing, lighting, and optic character recognition (OCR). The CLPR can be used in vehicle flow statistics, the checking of stolen vehicles, automatic charging systems in parking lots or garage management, and so on.

  1. Securing your PC and protecting your privacy.

    Science.gov (United States)

    Schloman, Barbara F

    2004-10-22

    Working in a networked information environment brings new opportunities for getting and sharing information. Regrettably, these benefits of the Internet are challenged by forces that would interfere to satisfy their own profit or malevolent motives. Your networked computer can be infected by viruses, worms, or Trojan horses or infiltrated by spyware, adware, or pop-ups. Without being aware of the dangers and taking precautionary steps, your PC is susceptible to being compromised and your privacy invaded. This column will highlight some of the dangers and offer basic steps for securing your computer and protecting your privacy.

  2. Evaluation of FPGA to PC feedback loop

    Science.gov (United States)

    Linczuk, Pawel; Zabolotny, Wojciech M.; Wojenski, Andrzej; Krawczyk, Rafal D.; Pozniak, Krzysztof T.; Chernyshova, Maryna; Czarski, Tomasz; Gaska, Michal; Kasprowicz, Grzegorz; Kowalska-Strzeciwilk, Ewa; Malinowski, Karol

    2017-08-01

    The paper presents the evaluation study of the performance of the data transmission subsystem which can be used in High Energy Physics (HEP) and other High-Performance Computing (HPC) systems. The test environment consisted of Xilinx Artix-7 FPGA and server-grade PC connected via the PCIe 4xGen2 bus. The DMA engine was based on the Xilinx DMA for PCI Express Subsystem1 controlled by the modified Xilinx XDMA kernel driver.2 The research is focused on the influence of the system configuration on achievable throughput and latency of data transfer.

  3. Determination of performance characteristics of scientific applications on IBM Blue Gene/Q

    Energy Technology Data Exchange (ETDEWEB)

    Evangelinos, C. [IBM Research Division, Cambridge, MA (United States); Walkup, R. E. [IBM, Yorktown Heights, NY (United States). Thomas J. Watson Research Center; Sachdeva, V. [IBM Research Division, Cambridge, MA (United States); Jordan, K. E. [IBM Research Division, Cambridge, MA (United States); Gahvari, H. [Univ. of Illinois, Urbana-Champaign, IL (United States). Computer Science Dept.; Chung, I. -H. [IBM, Yorktown Heights, NY (United States). Thomas J. Watson Research Center; Perrone, M. P. [IBM, Yorktown Heights, NY (United States). Thomas J. Watson Research Center; Lu, L. [IBM, Yorktown Heights, NY (United States). Thomas J. Watson Research Center; Liu, L. -K. [IBM, Yorktown Heights, NY (United States). Thomas J. Watson Research Center; Magerlein, K. [IBM, Yorktown Heights, NY (United States). Thomas J. Watson Research Center

    2013-02-13

    The IBM Blue Gene®/Q platform presents scientists and engineers with a rich set of hardware features such as 16 cores per chip sharing a Level 2 cache, a wide SIMD (single-instruction, multiple-data) unit, a five-dimensional torus network, and hardware support for collective operations. Especially important is the feature related to cores that have four “hardware threads,” which makes it possible to hide latencies and obtain a high fraction of the peak issue rate from each core. All of these hardware resources present unique performance-tuning opportunities on Blue Gene/Q. We provide an overview of several important applications and solvers and study them on Blue Gene/Q using performance counters and Message Passing Interface profiles. We also discuss how Blue Gene/Q tools help us understand the interaction of the application with the hardware and software layers and provide guidance for optimization. Furthermore, on the basis of our analysis, we discuss code improvement strategies targeting Blue Gene/Q. Information about how these algorithms map to the Blue Gene® architecture is expected to have an impact on future system design as we move to the exascale era.

  4. Solar energy system performance evaluation: seasonal report for IBM System IA, Huntsville, Alabama

    Energy Technology Data Exchange (ETDEWEB)

    1980-05-01

    The analysis used is based on instrumented system data monitored and collected for at least one full season of operation. The long-term field performance of the installed system is reported. The Solar Energy System, Sims Prototype System 1A, was designed by IBM to provide 50 to 60% of the space heating and domestic hot water (DHW) preheating load to a 2000 square foot floor space single faily residence in the Huntsville area. The load design temperature inside the building was to be maintained at 70 degrees fahrenheit with auxiliary energy for heating supplied by an electric heat pump assisted by an electric resistance strip heater. Auxiliary energy for domestic hot water is from a conventional 20-gallon DHW storage tank. The solar energy system, uses air as the heat transport medium, has a 720 square foot Solar Energy Products Collector Array, a 22-ton rock storage located within the office building, a pump, heat exchanger, air handler, pre-heat tank, fan and associated plumbing. The system has five different modes of operation.

  5. Intelligent Bioreactor Management Information System (IBM-IS) for Mitigation of Greenhouse Gas Emissions

    Energy Technology Data Exchange (ETDEWEB)

    Paul Imhoff; Ramin Yazdani; Don Augenstein; Harold Bentley; Pei Chiu

    2010-04-30

    Methane is an important contributor to global warming with a total climate forcing estimated to be close to 20% that of carbon dioxide (CO2) over the past two decades. The largest anthropogenic source of methane in the US is 'conventional' landfills, which account for over 30% of anthropogenic emissions. While controlling greenhouse gas emissions must necessarily focus on large CO2 sources, attention to reducing CH4 emissions from landfills can result in significant reductions in greenhouse gas emissions at low cost. For example, the use of 'controlled' or bioreactor landfilling has been estimated to reduce annual US greenhouse emissions by about 15-30 million tons of CO2 carbon (equivalent) at costs between $3-13/ton carbon. In this project we developed or advanced new management approaches, landfill designs, and landfill operating procedures for bioreactor landfills. These advances are needed to address lingering concerns about bioreactor landfills (e.g., efficient collection of increased CH4 generation) in the waste management industry, concerns that hamper bioreactor implementation and the consequent reductions in CH4 emissions. Collectively, the advances described in this report should result in better control of bioreactor landfills and reductions in CH4 emissions. Several advances are important components of an Intelligent Bioreactor Management Information System (IBM-IS).

  6. The genetic basis of natural variation for iron homeostasis in the maize IBM population.

    Science.gov (United States)

    Benke, Andreas; Urbany, Claude; Marsian, Johanna; Shi, Rongli; Wirén, Nicolaus von; Stich, Benjamin

    2014-01-09

    Iron (Fe) deficiency symptoms in maize (Zea mays subsp. mays) express as leaf chlorosis, growth retardation, as well as yield reduction and are typically observed when plants grow in calcareous soils at alkaline pH. To improve our understanding of genotypical variability in the tolerance to Fe deficiency-induced chlorosis, the objectives of this study were to (i) determine the natural genetic variation of traits related to Fe homeostasis in the maize intermated B73 × Mo17 (IBM) population, (ii) to identify quantitative trait loci (QTLs) for these traits, and (iii) to analyze expression levels of genes known to be involved in Fe homeostasis as well as of candidate genes obtained from the QTL analysis. In hydroponically-grown maize, a total of 47 and 39 QTLs were detected for the traits recorded under limited and adequate supply of Fe, respectively. From the QTL results, we were able to identify new putative candidate genes involved in Fe homeostasis under a deficient or adequate Fe nutritional status, like Ferredoxin class gene, putative ferredoxin PETF, metal tolerance protein MTP4, and MTP8. Furthermore, our expression analysis of candidate genes suggested the importance of trans-acting regulation for 2'-deoxymugineic acid synthase 1 (DMAS1), nicotianamine synthase (NAS3, NAS1), formate dehydrogenase 1 (FDH1), methylthioribose-1-phosphate isomerase (IDI2), aspartate/tyrosine/aromatic aminotransferase (IDI4), and methylthioribose kinase (MTK).

  7. The IBM HeadTracking Pointer: improvements in vision-based pointer control.

    Science.gov (United States)

    Kjeldsen, Rick

    2008-07-01

    Vision-based head trackers have been around for some years and are even beginning to be commercialized, but problems remain with respect to usability. Users without the ability to use traditional pointing devices--the intended audience of such systems--have no alternative if the automatic bootstrapping process fails. There is room for improvement in face tracking, and the pointer movement dynamics do not support accurate and efficient pointing. This paper describes the IBM HeadTracking Pointer, a system which attempts to directly address some of these issues. Head gestures are used to provide the end user a greater level of autonomous control over the system. A novel face-tracking algorithm reduces drift under variable lighting conditions, allowing the use of absolute, rather than relative, pointer positioning. Most importantly, the pointer dynamics have been designed to take into account the constraints of head-based pointing, with a non-linear gain which allows stability in fine pointer movement, high speed on long transitions and adjustability to support users with different movement dynamics. User studies have identified some difficulties with training the system and some characteristics of the pointer motion that take time to get used to, but also good user feedback and very promising performance results.

  8. Acquisition of Vallent by IBM: An insight into the Change Management Model and its feasibility in Cross Nation Scenario

    OpenAIRE

    Fatehpuria, Nidhi

    2008-01-01

    One of the biggest challenge facing today’s organizations involves change management as the ultra-competitive market place requires leaders to often try to alter the way they do business. To successfully transform the organizations to meet their goals would entail strong leadership to bring about the change together with employees that understand and are motivated to undergo the change. In this research, my objective is to investigate specifically the change management at IBM after the acquis...

  9. Development of a transgenic early flowering pear (Pyrus communis L.) genotype by RNAi silencing of PcTFL1-1 and PcTFL1-2.

    Science.gov (United States)

    Freiman, Aviad; Shlizerman, Lyudmila; Golobovitch, Sara; Yablovitz, Zeev; Korchinsky, Raia; Cohen, Yuval; Samach, Alon; Chevreau, Elisabeth; Le Roux, Pierre-Marie; Patocchi, Andrea; Flaishman, Moshe A

    2012-06-01

    Trees require a long maturation period, known as juvenile phase, before they can reproduce, complicating their genetic improvement as compared to annual plants. 'Spadona', one of the most important European pear (Pyrus communis L.) cultivars grown in Israel, has a very long juvenile period, up to 14 years, making breeding programs extremely slow. Progress in understanding the molecular basis of the transition to flowering has revealed genes that accelerate reproductive development when ectopically expressed in transgenic plants. A transgenic line of 'Spadona', named Early Flowering-Spadona (EF-Spa), was produced using a MdTFL1 RNAi cassette targeting the native pear genes PcTFL1-1 and PcTFL1-2. The transgenic line had three T-DNA insertions, one assigned to chromosome 2 and two to chromosome 14 PcTFL1-1 and PcTFL1-2 were completely silenced, and EF-Spa displayed an early flowering phenotype: flowers developed already in tissue culture and on most rooted plants 1-8 months after transfer to the greenhouse. EF-Spa developed solitary flowers from apical or lateral buds, reducing vegetative growth vigor. Pollination of EF-Spa trees generated normal-shaped fruits with viable F1 seeds. The greenhouse-grown transgenic F1 seedlings formed shoots and produced flowers 1-33 months after germination. Sequence analyses, of the non-transgenic F1 seedlings, demonstrated that this approach can be used to recover seedlings that have no trace of the T-DNA. Thus, the early flowering transgenic line EF-Spa obtained by PcTFL1 silencing provides an interesting tool to accelerate pear breeding.

  10. Data of evolutionary structure change: 1A54A-1PC3A [Confc[Archive

    Lifescience Database Archive (English)

    Full Text Available 1A54A-1PC3A 1A54 1PC3 A A --------EASLTGAGATFPAPVYAKWADTYQKET-GNK...A 378 PHE CA 440 GLN CA 487 PHE CA 535 1PC3... A 1PC3A LYS CA 277 ASN CA 192 1PC3 A 1PC3A LSKQDPEGWGK

  11. Pc promoter from class 2 integrons and the cassette transcription pattern it evokes.

    Science.gov (United States)

    da Fonseca, Érica Lourenço; dos Santos Freitas, Fernanda; Vicente, Ana Carolina Paulo

    2011-04-01

    Integrons are considered expression systems due to the presence of Pc promoters that drive gene cassette transcription. The role and configurations of Pc are well known in class 1 integrons; however, this region has not yet been identified in class 2 integrons. This study aimed to characterize the Pc promoter from class 2 integrons and to determine the effect of gene cassette position on transcription driven by this promoter. The class 2 cassette arrays from Klebsiella pneumoniae and Vibrio cholerae strains were determined by sequencing. Transcription analyses were performed by real-time RT-PCR and relative quantification was carried out by comparing the transcripts of each normalized gene inserted in the integron to each other. The resistance profile was determined by the disc diffusion method. The class 2 Pc promoter was characterized by 5' rapid amplification of cDNA ends and promoter prediction programs. Sequence analysis revealed the presence of the dfrA1-sat2-aadA1-ybeA and sat2-aadA1-ybeA arrangements in K. pneumoniae and V. cholerae strains, respectively. Real-time RT-PCR showed that the transcription of the first cassettes was higher than that of distal ones in wild-type and recombinant strains. All strains were resistant, indicating cassette expression. The Pc promoter of class 2 integrons (-35 TTTAAT |16 bp| -10 TAAAAT) was determined based on in silico analyses and on the transcription start site sequence of the class 2 integron cassette array. The Pc from class 2 integrons was characterized for the first time and the cassette position effect on transcription was demonstrated.

  12. Sporadic-inclusion body myositis (s-IBM) is not so prevalent in Istanbul/Turkey: a muscle biopsy based survey.

    Science.gov (United States)

    Oflazer, P Serdaroglu; Deymeer, F; Parman, Y

    2011-06-01

    In a muscle biopsy based study, only 9 out of 5450 biopsy samples, received from all parts of greater Istanbul area, had typical clinical and most suggestive light microscopic sporadic-inclusion body myositis (s-IBM) findings. Two other patients with and ten further patients without characteristic light microscopic findings had referring diagnosis of s-IBM. As the general and the age-adjusted populations of Istanbul in 2010 were 13.255.685 and 2.347.300 respectively, the calculated corresponding 'estimated prevalences' of most suggestive s-IBM in the Istanbul area were 0.679 X 10(-6) and 3.834 X 10(-6). Since Istanbul receives heavy migration from all regions of Turkey and ours is the only muscle pathology laboratory in Istanbul, projection of these figures to the Turkish population was considered to be reasonable and an estimate of the prevalence of s-IBM in Turkey was obtained. The calculated 'estimated prevalence' of s-IBM in Turkey is lower than the previously reported rates from other countries. The wide variation in the prevalence rates of s-IBM may reflect different genetic, immunogenetic or environmental factors in different populations.

  13. Pachyonychia congenita with late onset (PC tarda

    Directory of Open Access Journals (Sweden)

    A Sravanthi

    2016-01-01

    Full Text Available Pachyonychia congenita is a rare type of ectodermal dysplasia further classified into 4 types. Cutaneous manifestations seen in most of the cases of Pachyonychia congenita include palmoplantar keratoderma, follicular hyperkeratosis, wedge shaped nails, oral leukokeratosis and woolly hair. A 25-year-old male presented to us with thickened nails and scanty scalp hair. On examination, we noticed hyperkeratotic plaques over both the soles, palmoplantar hyperhidrosis and yellowish discoloration, wedging with subungual hyperkeratosis of all the nails. Follicular hyperkeratotic papules and steatocystoma multiplex were also observed over the scalp and face. The patient had history of natal teeth and on dental examination, lower central incisors were absent. All cutaneous changes in our case had manifested first in the 2nd decade except for natal teeth. All the above features suggested the diagnosis of pachyonychia congenita with late onset (PC tarda, which is an infrequently reported rare variant.

  14. Pathway Controlled Penetration (PcP)

    Energy Technology Data Exchange (ETDEWEB)

    Knight, Earl E. [Los Alamos National Laboratory; Rougier, Esteban [Los Alamos National Laboratory; Zubelewicz, Aleksander [Los Alamos National Laboratory

    2012-08-29

    The technical approach employs advanced computational simulation tools to demonstrate how current assets can destroy RWK-RFI-12-0001's HDBT, a tunnel complex with two portals built into the base of a granite mountain. The granite over layer is assumed to be 60 meters thick over both portals and 80 meters over the facility's mission space. Key S&T is the completed development of a highly innovative viscoplastic fracture material model, 3D parallel gas-fracture capabilities into FDEM, and a stochastic handling of the material properties. Phase I - Develop and validate code simulation tools: (1) develop, incorporate and validate AZ-Frac material model for granite; and (2) Develop and incorporate gas-driven-fracture modeling into LANL's FDEM MUNROU code; (3) Develop and incorporate stochastic features into FDEM modeling. Phase II - Conduct PcP analysis on above HDBT: (1) Acquire HDBT design data, develop simulation model; and (2) Evaluate and select most promising defeat alternative. Phase III - Deliver code, train Service target analysts, and conduct simulations against real world HDBTs. PcP uses advanced computer simulations to enhance HDBT functional defeat efforts. Newly developed material models that account for fractural energy coupled with the finite discrete element methodology (FDEM) will provide targeting packages that will create penetration avenues for current or future lethality options. This novel computational approach requires full 3D geologic and structure characterization as well as significant high performance computing capabilities. The goal is to distinctively alter the targeting paradigm by leveraging critical DoD assets along with insitu geologic strata. In other words, assets will utilize underground rock structure to their benefit by creating rubbilization zones that will allow pathway controlled penetration.

  15. SIOB: a FORTRAN code for least-squares shape fitting several neutron transmission measurements using the Breit--Wigner multilevel formula. [For IBM-360/91

    Energy Technology Data Exchange (ETDEWEB)

    de Saussure, G.; Olsen, D. K.; Perez, R. B.

    1978-05-01

    The FORTRAN-IV code SIOB was developed to least-square fit the shape of neutron transmission curves. Any number of measurements on a common energy scale for different sample thicknesses can be simultaneously fitted. The computed transmission curves can be broadened with either a Gaussian or a rectangular resolution function or both, with the resolution width a function of energy. The total cross section is expressed as a sum of single-level or multilevel Breit--Wigner terms and Doppler broadened by using the fast interpolation routine QUICKW. The number of data points, resonance levels, and variables which can be handled simultaneously is only limited by the overall dimensions of two arrays in the program and by the stability of the matrix inversion. In a test problem seven transmissions each with 3750 data points were simultaneously fitted with 74 resonances and 110 variable parameters. The problem took 47 min of CPU time on an IBM-360/91, for 3 iterations. 3 figures, 2 tables.

  16. Computer Program NIKE

    DEFF Research Database (Denmark)

    Spanget-Larsen, Jens

    2014-01-01

    FORTRAN source code for program NIKE (PC version of QCPE 343). Sample input and output for two model chemical reactions are appended: I. Three consecutive monomolecular reactions, II. A simple chain mechanism...

  17. Mixing of MnPc electronic states at the MnPc/Au(110) interface

    Science.gov (United States)

    Gargiani, Pierluigi; Lisi, Simone; Avvisati, Giulia; Mondelli, Pierluigi; Fatale, Sara; Betti, Maria Grazia

    2017-10-01

    Manganese-phthalocyanines form assembled chains with a variety of ordered super-structures, flat lying along the Au(110) reconstructed channels. The chains first give rise to a ×5 symmetry reconstruction, while further deposition of MnPc leads to a ×7 periodicity at the completion of the first single layer. A net polarization with the formation of an interface dipole is mainly due to the molecular π-states located on the macrocycles pyrrole rings, while the central metal ion induces a reduction in the polarization, whose amount is related to the Mn-Au interaction. The adsorption-induced interface polarization is compared to other 3d-metal phthalocyanines, to unravel the role of the central metal atom configuration in the interaction process of the d-states. The MnPc adsorption on Au(110) induces the re-hybridization of the electronic states localized on the central metal atom, promoting a charge redistribution of the molecular orbitals of the MnPc molecules. The molecule-substrate interaction is controlled by a symmetry-determined mixing between the electronic states, involving also the molecular empty orbitals with d character hybridized with the nitrogen atoms of the pyrrole ring, as deduced by photoemission and X-ray absorption spectroscopy exploiting light polarization. The symmetry-determined mixing between the electronic states of the Mn metal center and of the Au substrate induces a density of states close to the Fermi level for the ×5 phase.

  18. Characteristics of CoPc/CdS hybrid diode device

    Indian Academy of Sciences (India)

    Ag contact metal deposited on CoPc by e-beam evaporation and glass/ITO/CdS/ CoPc/Ag structures were fabricated. Rectification ratio, ideality factor, barrier height and junction parameters of the devices were determined. It is shown that device has diode characteristics with the ideality factor (n) of 4.8, rectification ratio of ...

  19. The response effect of pheochromocytoma (PC12) cell lines to ...

    African Journals Online (AJOL)

    The toxicity of oxidized multi-walled carbon nanotubes (o-MWCNTs) are of utmost concern and in most in-vitro studies conducted so far are on dendritic cell (DC) lines with limited data on PC12 cell lines. Objectives: We focused on the effect of o-MWCNTs in PC12 cells in vitro: a common model cell for neurotoxicity.

  20. Transforming PC Power Supplies into Smart Car Battery Conditioners

    Science.gov (United States)

    Rodriguez-Ascariz, J. M.; Boquete-Vazquez, L.

    2011-01-01

    This paper describes a laboratory project consisting of a PC power supply modification into an intelligent car-battery conditioner with both wireless and wired networking capabilities. Adding a microcontroller to an average PC power supply transforms it into a flexible, intelligent device that can be configured and that is suitable to keep car…

  1. PrPC from stem cells to cancer

    Directory of Open Access Journals (Sweden)

    Séverine eMartin-Lannerée

    2014-09-01

    Full Text Available The cellular prion protein PrPC was initially discovered as the normal counterpart of the pathological scrapie prion protein PrPSc, the main component of the infectious agent of Transmissible Spongiform Encephalopathies. While clues as to the physiological function of this ubiquitous protein were greatly anticipated from the development of knock-out animals, PrP-null mice turned out to be viable and to develop without major phenotypic abnormalities. Notwithstanding, the discovery that hematopoietic stem cells from PrP-null mice have impaired long-term repopulating potential has set the stage for investigating into the role of PrPC in stem cell biology. A wealth of data have now exemplified that PrPC is expressed in distinct types of stem cells and regulates their self-renewal as well as their differentiation potential. A role for PrPC in the fate restriction of embryonic stem cells has further been proposed. Paralleling these observations, an overexpression of PrPC has been documented in various types of tumours. In line with the contribution of PrPC to stemness and to the proliferation of cancer cells, PrPC was recently found to be enriched in subpopulations of tumour-initiating cells. In the present review, we summarize the current knowledge of the role played by PrPC in stem cell biology and discuss how the subversion of its function may contribute to cancer progression.

  2. Development Of A Multi-Channel Personal Computer (Pc) Based ...

    African Journals Online (AJOL)

    Development Of A Multi-Channel Personal Computer (Pc) Based Data Logger. ... Journal of Science and Technology (Ghana) ... PC (Personal Computer) based instrumentation is getting more attention because of three technological enhancements; increasing reliability of PCs, steadily decreasing cost of hard drive space ...

  3. IBM Software Defined Storage and ownCloud Enterprise Editon - a perfect match for hyperscale Enterprise File Sync and Share

    CERN Multimedia

    CERN. Geneva

    2014-01-01

    IBM Software Defined Storage, in particular the technology offering codenamed Elastic Storage (based on GPFS technology) has proven to be an ideal match for Enterprise File Sync and Share (EFSS) solutions that need highly scalable storage. The presentation will provide insight into the integration of Elastic Storage with the ownCloud Enterprise Edition (based on Open Source technology) software that showed impressive scalability and performance metrics during a proof-of-concept phase of an installation that is supposed to serve 300000 users when fully deployed.

  4. IBM mainframe security beyond the basics : a practical guide from a z/OS and RACF perspective

    CERN Document Server

    Dattani, Dinesh D

    2013-01-01

    Rather than rehashing basic information-such as command syntax-already available in other publications, this book focuses on important security and audit issues, business best practices, and compliance, discussing the important issues in IBM mainframe security. Mainframes are the backbone of most large IT organizations; security cannot be left to chance. With very little training available to the younger crowd, and older, more experienced personnel retiring or close to retiring, there is a need in mainframe security skills at the senior level. Based on real-life experiences, issues, and soluti

  5. FROM THE LEWIS AND CLARK EXPEDITION TO IBM, DELL, AND SOUTHWEST AIRLINES: TEACHING HISTORY AND LEADERSHIP TO BUSINESS STUDENTS

    Directory of Open Access Journals (Sweden)

    Jeffrey J. Matthews

    2006-01-01

    Full Text Available History is not a tomb of dead facts but a resource that can inform and improve everyday decision making. Experience as an analytical tool is invaluable for solving problems in changing and competitive environments. “From the Lewis and Clark Expedition,” which coincides with the National Lewis & Clark Bicentennial Commemoration (2003—2006, demonstrates how contemporary business concepts of visionary leadership, systematic planning, and organizational climate were instrumental to the success of Thomas Jefferson's “Corps of Discovery” and shows how a mastery of these concepts contributed to the successes of the pioneering US corporations IBM, Southwest Airlines, and Dell.

  6. User`s guide and documentation manual for ``PC-Gel`` simulator

    Energy Technology Data Exchange (ETDEWEB)

    Chang, Ming-Ming; Gao, Hong W.

    1993-10-01

    PC-GEL is a three-dimensional, three-phase (oil, water, and gas) permeability modification simulator developed by incorporating an in-situ gelation model into a black oil simulator (BOAST) for personal computer application. The features included in the simulator are: transport of each chemical species of the polymer/crosslinker system in porous media, gelation reaction kinetics of the polymer with crosslinking agents, rheology of the polymer and gel, inaccessible pore volume to macromolecules, adsorption of chemical species on rock surfaces, retention of gel on the rock matrix, and permeability reduction caused by the adsorption of polymer and gel. The in-situ gelation model and simulator were validated against data reported in the literature. The simulator PC-GEL is useful for simulating and optimizing any combination of primary production, waterflooding, polymer flooding, and permeability modification treatments. A general background of permeability modification using crosslinked polymer gels is given in Section I and the governing equations, mechanisms, and numerical solutions of PC-GEL are given in Section II. Steps for preparing an input data file with reservoir and gel-chemical transport data, and recurrent data are described in Sections III and IV, respectively. Example data inputs are enclosed after explanations of each input line to help the user prepare data files. Major items of the output files are reviewed in Section V. Finally, three sample problems for running PC-GEL are described in Section VI, and input files and part of the output files of these problems are listed in the appendices. For the user`s reference a copy of the source code of PC-GEL computer program is attached in Appendix A.

  7. Photovoltaic properties of SnCl{sub 2}Pc films and SnCl{sub 2}Pc/pentacene heterostructures

    Energy Technology Data Exchange (ETDEWEB)

    Lutsyk, P.; Vertsimakha, Ya. [Institute of Physics, National Academy of Sciences of Ukraine, Prosp. Nauky 46, 03028 Kyiv (Ukraine); Misiewicz, J.; Podhorodecki, A. [Institute of Physics, Wroclaw University of Technology, Wyb. S. Wyspianskiego 27, 50-370 Wroclaw (Poland)

    2007-01-05

    The optical and photovoltaic properties of dichlorotin phthalocyanine (SnCl{sub 2}Pc) films and SnCl{sub 2}Pc/pentacene (Pn) heterostructures (HS) have been studied. Weak bands at 1.35, 1.52 and 2.05eV have been found in absorption and modulated photoreflectance spectra of SnCl{sub 2}Pc films. These bands can be caused by the formation of charge transfer states. The low concentration of recombination centers of charge carriers has been formed on a free surface of SnCl{sub 2}Pc films. This concentration essentially decreases at air evacuation before vacuum deposition of a Pn layer. Therefore, interface with an insignificant recombination rate of charge carriers is formed for SnCl{sub 2}Pc/Pn HS. (author)

  8. Image Registration Algorithm For A PC-Based System

    Science.gov (United States)

    Nutter, Brian S.; Mitra, Sunanda; Krile, Thomas F.

    1988-01-01

    Image registration algorithms are essential for subtractive analysis of sequential images. Discrepancies in lighting, image orientation, and scale must be minimized before effective subtraction of two images can occur. We have successfully implemented computationally intensive algorithms for registration, which include illuminance normalization and magnification correction, in a PC-based image processing system. A homomorphic filter in the spatial domain is used to reduce the illumination variations in the images. A modified sequential similarity detection technique is used to derive the minimum error factor associated with each combination of translation, magnification, and rotation variations. Each variation of the test image is masked with one of three masks, and the squares of the pixel intensity differences are summed for every test image. An adaptive threshold is used to decrease the time required for a misfit by aborting the test image under consideration when its summation exceeds the value of the previous best fit summation. After the best fit parameters are obtained, they are used to register the images so that the images can be subtracted. The difference image is subjected to further image enhancement operations. The execution time of the image registration algorithm has been reduced through use of a hybrid program written in C and Assembly languages. Applications of the registration algorithms in analysis of fundus images will be presented.

  9. Run-09 pC polarimeter analysis

    Energy Technology Data Exchange (ETDEWEB)

    Alekseev, I.; Aschenauer, E.; Atoyan, G.; Bazilevsky, A.; Gill, R.; Huang, H.; Lee, S.; Li, X.; Makdisi, Y.; Morozov, B.; Nakagawa, I.; Svirida, D.; Zelenski, A.

    2010-08-01

    Analysis of PC polarimeter data at {radical}s = 200 and 500 GeV from Run9 is presented. Final polarization results, fill-by-fill, for blue and yellow beams, as to be used by RHIC experiments (in collisions) are released and collected in http://www4.rcf.bnl.gov/cnipol/pubdocs/Run09Offline/. Global relative systematic uncertainties {delta}P/P (to be considered as correlated from fill to fill) are 4.7% for 100 GeV beams, and 8.3% (12.1%) for blue (yellow) 250 GeV beams. For a product of two beam polarizations P{sub B} {center_dot} P{sub Y} (used in double spin asymmetry measurements) the relative uncertainty {delta}(P{sub B} {center_dot} P{sub Y})/(P{sub B} {center_dot} P{sub Y}) 8.8% for 100 GeV beams and 18.5% for 250 GeV beams. For the average between two beam polarization (P{sub B} + P{sub Y})/2 (used in single spin asymmetry measurements, when data from two polarized beams are combined) the relative uncertainty is 4.4% for 100 GeV beams and 9.2% for 250 GeV beams. Larger uncertainties for 250 GeV beams relate to significant rate related systematic effects experienced in the first part of Run9 (due to thicker targets used and smaller trans. beam size at higher beam energy).

  10. Cancer mortality in IBM Endicott plant workers, 1969-2001: an update on a NY production plant.

    Science.gov (United States)

    Clapp, Richard W; Hoffman, Kate

    2008-04-28

    In response to concerns expressed by workers at a public meeting, we analyzed the mortality experience of workers who were employed at the IBM plant in Endicott, New York and died between 1969-2001. An epidemiologic feasibility assessment indicated potential worker exposure to several known and suspected carcinogens at this plant. We used the mortality and work history files produced under a court order and used in a previous mortality analysis. Using publicly available data for the state of New York as a standard of comparison, we conducted proportional cancer mortality (PCMR) analysis. The results showed significantly increased mortality due to melanoma (PCMR = 367; 95% CI: 119, 856) and lymphoma (PCMR = 220; 95% CI: 101, 419) in males and modestly increased mortality due to kidney cancer (PCMR = 165; 95% CI: 45, 421) and brain cancer (PCMR = 190; 95% CI: 52, 485) in males and breast cancer (PCMR = 126; 95% CI: 34, 321) in females. These results are similar to results from a previous IBM mortality study and support the need for a full cohort mortality analysis such as the one being planned by the National Institute for Occupational Safety and Health.

  11. The genetic basis of flecking and its relationship to disease resistance in the IBM maize mapping population.

    Science.gov (United States)

    Vontimitta, Vijay; Olukolu, Bode A; Penning, Bryan W; Johal, Gurmukh; Balint-Kurti, P J

    2015-11-01

    In this paper, we determine the genetic architecture controlling leaf flecking in maize and investigate its relationship to disease resistance and the defense response. Flecking is defined as a mild, often environmentally dependent lesion phenotype observed on the leaves of several commonly used maize inbred lines. Anecdotal evidence suggests a link between flecking and enhanced broad-spectrum disease resistance. Neither the genetic basis underlying flecking nor its possible relationship to disease resistance has been systematically evaluated. The commonly used maize inbred Mo17 has a mild flecking phenotype. The IBM-advanced intercross mapping population, derived from a cross between Mo17 and another commonly used inbred B73, has been used for mapping a number of traits in maize including several related to disease resistance. In this study, flecking was assessed in the IBM population over 6 environments. Several quantitative trait loci for flecking were identified, with the strongest one located on chromosome 6. Low but moderately significant correlations were observed between stronger flecking and higher disease resistance with respect to two diseases, southern leaf blight and northern leaf blight and between stronger flecking and a stronger defense response.

  12. Cancer mortality in IBM Endicott plant workers, 1969–2001: an update on a NY production plant

    Directory of Open Access Journals (Sweden)

    Hoffman Kate

    2008-04-01

    Full Text Available Abstract Background In response to concerns expressed by workers at a public meeting, we analyzed the mortality experience of workers who were employed at the IBM plant in Endicott, New York and died between 1969–2001. An epidemiologic feasibility assessment indicated potential worker exposure to several known and suspected carcinogens at this plant. Methods We used the mortality and work history files produced under a court order and used in a previous mortality analysis. Using publicly available data for the state of New York as a standard of comparison, we conducted proportional cancer mortality (PCMR analysis. Results The results showed significantly increased mortality due to melanoma (PCMR = 367; 95% CI: 119, 856 and lymphoma (PCMR = 220; 95% CI: 101, 419 in males and modestly increased mortality due to kidney cancer (PCMR = 165; 95% CI: 45, 421 and brain cancer (PCMR = 190; 95% CI: 52, 485 in males and breast cancer (PCMR = 126; 95% CI: 34, 321 in females. Conclusion These results are similar to results from a previous IBM mortality study and support the need for a full cohort mortality analysis such as the one being planned by the National Institute for Occupational Safety and Health.

  13. A Conceptual Framework for the Electronic Performance Support Systems within IBM Lotus Notes 6 (LN6 Example

    Directory of Open Access Journals (Sweden)

    Servet BAYRAM

    2005-10-01

    Full Text Available A Conceptual Framework for the Electronic PerformanceSupport Systems within IBM Lotus Notes 6 (LN6 Example Assoc. Prof. Dr. Servet BAYRAM Computer Education & Instructional Technologies Marmara University, TURKEYsbayram@marmara.edu.tr ABSTRACT The concept of Electronic Performance Support Systems (EPSS is containing multimedia or computer based instruction components that improves human performance by providing process simplification, performance information and decision support system. EPSS has become a hot topic for organizational development, human resources, performance technology, training, and educational development professionals. A conceptual framework of EPSS is constructed under five interrelated and interdependent domains for educational implications. The domains of the framework are online collaboration, cost-effectiveness, motivation, service management, and performance empowering. IBM Lotus Notes 6 (LN6 is used as an example application tool to illustrate the power of this framework. The framework describes a set of relevant events based upon deductive analyses for improving our understanding of the EPSS and its implications on education and training. The article is also pointed out that there are some similarities between the EPSS’ and the LN6’s specific features within this conceptual framework. It can provide some guidelines and benefits to researchers, educators, and designers as well.

  14. Centro de investigaciones I.B.M., en las proximidades de Niza

    Directory of Open Access Journals (Sweden)

    Breuer, Marcel

    1964-06-01

    Full Text Available In order to fit in with the landscape and also meet the local building regulations, this Centre was planned as a two storey building, lifted above the ground by columns, whose height varies between 4.29 and 7.92 m, according to the ground slope. The building planform is in the shape of a double Y, and has, among others, the advantages of making it possible to provide natural illumination to all the rooms, reduce the maximum distance of the most distant parts of the building from the vertical communications, and avoid that one wing of the building shall interrupt the view of the other parts of it. GENERAL ORGANISATION. The ground floor is taken up with the mechanical equipment, porter's lodge, and other services. The other levels provide room for the scientific research laboratories, study rooms, washing rooms, along the northern and western wings; and administrative offices, staff rooms, cafeteria, kitchen and stores along the southern and eastern wings. At the centre there is an exhibition hall, visible from the main entrance hall, and a full set of IBM machines, in working order, are displayed. The folded roof structure is noteworthy. It is circular in shape, and was initially planned as a car and bicycle garage, but now serves as a lecture hall. It is located near the entry ramp, and consists of prefabricated slabs, assembled around a central prestressed ring.Con el fin de respetar el paisaje, así como también los deseos del Municipio—el cual se oponía a una construcción en altura o de aspecto comercial que no se integrase en aquél—, se adoptó para este Centro una solución a base de una edificación de dos plantas, separada del suelo por soportes, cuya altura varía de 4,29 a 7,92 m, según el desnivel del terreno. La planta, en forma de doble «Y», que presenta la edificación ofrece, entre otras ventajas, la de permitir la iluminación natural de todos los locales, reducir las distancias de las dependencias extremas respecto de

  15. Annual review in automatic programming

    CERN Document Server

    Goodman, Richard

    2014-01-01

    Annual Review in Automatic Programming, Volume 4 is a collection of papers that deals with the GIER ALGOL compiler, a parameterized compiler based on mechanical linguistics, and the JOVIAL language. A couple of papers describes a commercial use of stacks, an IBM system, and what an ideal computer program support system should be. One paper reviews the system of compilation, the development of a more advanced language, programming techniques, machine independence, and program transfer to other machines. Another paper describes the ALGOL 60 system for the GIER machine including running ALGOL pro

  16. CERN Physics Screen Saver: Help LHC tracking studies on your PC

    CERN Multimedia

    2004-01-01

    Many PC users are familiar with screensavers such as SETI@home and FightAIDS@home. These screensavers take advantage of times when your PC is idle to do useful computing on a particular scientific problem. SETI@home, which analyses radio-astronomy data for signs of extraterrestrial intelligence, has been downloaded by over 5 million people. Similar programs are now sold commercially, and installed in major corporations to provide extra computing power at low cost. CERN 's IT Department is interested in evaluating this sort of technology for the future. Most of the scientific computing challenges that the LHC experiments are facing will require access to large amounts of storage, and cannot be run on individual PCs. However, there are exceptions. A program called SixTrack, which simulates particles traveling around the LHC to study the stability of their orbits, can fit on a single PC and requires relatively little input or output. SixTrack, which was developed by Frank Schmidt of the AB Department, produces r...

  17. The Upper- to Middle-Crustal Section of the Alisitos Oceanic Arc, (Baja, Mexico): an Analog of the Izu-Bonin-Marianas (IBM) Arc

    Science.gov (United States)

    Medynski, S.; Busby, C.; DeBari, S. M.; Morris, R.; Andrews, G. D.; Brown, S. R.; Schmitt, A. K.

    2016-12-01

    The Rosario segment of the Cretaceous Alisitos arc in Baja California is an outstanding field analog for the Izu-Bonin-Mariana (IBM) arc, because it is structurally intact, unmetamorphosed, and has superior three-dimensional exposures of an upper- to middle-crustal section through an extensional oceanic arc. Previous work1, done in the pre-digital era, used geologic mapping to define two phases of arc evolution, with normal faulting in both phases: (1) extensional oceanic arc, with silicic calderas, and (2) oceanic arc rifting, with widespread diking and dominantly mafic effusions. Our new geochemical data match the extensional zone immediately behind the Izu arc front, and is different from the arc front and rear arc, consistent with geologic relations. Our study is developing a 3D oceanic arc crustal model, with geologic maps draped on Google Earth images, and GPS-located outcrop information linked to new geochemical, geochronological and petrographic data, with the goal of detailing the relationships between plutonic, hypabyssal, and volcanic rocks. This model will be used by scientists as a reference model for past (IBM-1, 2, 3) and proposed IBM (IBM-4) drilling activities. New single-crystal zircon analysis by TIMS supports the interpretation, based on batch SIMS analysis of chemically-abraded zircon1, that the entire upper-middle crustal section accumulated in about 1.5 Myr. Like the IBM, volcanic zircons are very sparse, but zircon chemistry on the plutonic rocks shows trace element compositions that overlap to those measured in IBM volcanic zircons by A. Schmitt (unpublished data). Zircons have U-Pb ages up to 20 Myr older than the eruptive age, suggesting remelting of older parts of the arc, similar to that proposed for IBM (using different evidence). Like IBM, some very old zircons are also present, indicating the presence of old crustal fragments, or sediments derived from them, in the basement. However, our geochemical data show that the magmas are

  18. 2010 ME70 Workshop (PC1003, EK60)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The third leg of the 2010 SEAMAP Reeffish Survey, PC 1003, was originally scheduled as an experimental multibeam sonar workshop. However, on July 12, 2010, FSV...

  19. Single-event upset in advanced PowerPC microprocessors

    Science.gov (United States)

    Irom, F.; Swift, G. M.; Farmanesh, F.; Millward, D. G.

    2002-01-01

    Proton and heavy-ion single-event upset susceptibility has been measured for the MotorolaPowerPC7400. The results show that this advanced device has low upset susceptibility, despite the scaling and design advances.

  20. CoPc and CoPcF16 on gold: Site-specific charge-transfer processes

    Directory of Open Access Journals (Sweden)

    Fotini Petraki

    2014-04-01

    Full Text Available Interface properties of cobalt(II phthalocyanine (CoPc and cobalt(II hexadecafluoro-phthalocyanine (CoPcF16 to gold are investigated by photo-excited electron spectroscopies (X-ray photoemission spectroscopy (XPS, ultraviolet photoemission spectroscopy (UPS and X-ray excited Auger electron spectroscopy (XAES. It is shown that a bidirectional charge transfer determines the interface energetics for CoPc and CoPcF16 on Au. Combined XPS and XAES measurements allow for the separation of chemical shifts based on different local charges at the considered atom caused by polarization effects. This facilitates a detailed discussion of energetic shifts of core level spectra. The data allow the discussion of site-specific charge-transfer processes.

  1. Epitaxial growth and electronic properties of well ordered phthalocyanine heterojunctions MnPc/F{sub 16}CoPc

    Energy Technology Data Exchange (ETDEWEB)

    Lindner, Susi; Mahns, Benjamin; Treske, Uwe; Knupfer, Martin [IFW Dresden, P.O. Box 270116, D-01171 Dresden (Germany); Vilkov, Oleg [Center for Physical Methods of Surface Investigation, St. Petersburg State University, Ulyanovskaya Str. 1, St. Petersburg 198504, Russia and Institute of Solid State Physics, University of Technology Dresden, Zellescher Weg 16, D-01062 Dresden (Germany); Haidu, Francisc; Fronk, Michael; Zahn, Dietrich R. T. [Physics Department/Semiconductor Physics, Chemnitz University of Technology, Reichenhainer Str. 70, D-09126 Chemnitz (Germany)

    2014-09-07

    We have prepared phthalocyanine heterojunctions out of MnPc and F{sub 16}CoPc, which were studied by means of X-ray absorption spectroscopy. This heterojunction is characterized by a charge transfer at the interface, resulting in charged MnPc{sup δ} {sup +} and F{sub 16}CoPc{sup δ} {sup −} species. Our data reveal that the molecules are well ordered and oriented parallel to the substrate surface. Furthermore, we demonstrate the filling of the Co 3d{sub z{sup 2}} orbital due to the charge transfer, which supports the explanation of the density functional theory, that the charge transfer is local and affects the metal centers only.

  2. Case Study: IBM Watson Analytics Cloud Platform as Analytics-as-a-Service System for Heart Failure Early Detection

    Directory of Open Access Journals (Sweden)

    Gabriele Guidi

    2016-07-01

    Full Text Available In the recent years the progress in technology and the increasing availability of fast connections have produced a migration of functionalities in Information Technologies services, from static servers to distributed technologies. This article describes the main tools available on the market to perform Analytics as a Service (AaaS using a cloud platform. It is also described a use case of IBM Watson Analytics, a cloud system for data analytics, applied to the following research scope: detecting the presence or absence of Heart Failure disease using nothing more than the electrocardiographic signal, in particular through the analysis of Heart Rate Variability. The obtained results are comparable with those coming from the literature, in terms of accuracy and predictive power. Advantages and drawbacks of cloud versus static approaches are discussed in the last sections.

  3. Salinomycin Exerts Anticancer Effects on PC-3 Cells and PC-3-Derived Cancer Stem Cells In Vitro and In Vivo

    Directory of Open Access Journals (Sweden)

    Yunsheng Zhang

    2017-01-01

    Full Text Available Salinomycin is an antibiotic isolated from Streptomyces albus that selectively kills cancer stem cells (CSCs. However, the antitumor mechanism of salinomycin is unclear. This study investigated the chemotherapeutic efficacy of salinomycin in human prostate cancer PC-3 cells. We found that cytotoxicity of salinomycin to PC-3 cells was stronger than to nonmalignant prostate cell RWPE-1, and exposure to salinomycin induced G2/M phage arrest and apoptosis of PC-3 cells. A mechanistic study found salinomycin suppressed Wnt/β-catenin pathway to induce apoptosis of PC-3 cells. An in vivo experiment confirmed that salinomycin suppressed tumorigenesis in a NOD/SCID mice xenograft model generated from implanted PC-3 cells by inhibiting the Wnt/β-catenin pathway, since the total β-catenin protein level was reduced and the downstream target c-Myc level was significantly downregulated. We also showed that salinomycin, but not paclitaxel, triggered more apoptosis in aldehyde dehydrogenase- (ALDH- positive PC-3 cells, which were considered as the prostate cancer stem cells, suggesting that salinomycin may be a promising chemotherapeutic to target CSCs. In conclusion, this study suggests that salinomycin reduces resistance and relapse of prostate tumor by killing cancer cells as well as CSCs.

  4. The impact of Internet and PC addiction in school performance of Cypriot adolescents.

    Science.gov (United States)

    Siomos, Konstantinos; Paradeisioti, Anna; Hadjimarcou, Michalis; Mappouras, Demetrios G; Kalakouta, Olga; Avagianou, Penelope; Floros, Georgios

    2013-01-01

    In this paper we present the results of a cross-sectional survey designed to ascertain Internet and personal computer (PC) addiction in the Republic of Cyprus. This is a follow-up to a pilot study conducted one year earlier. Data were collected from a representative sample of the adolescent student population of the first and fourth grades of high school. Total sample was 2684 students, 48.5% of them male and 51.5% female. Research material included extended demographics and an Internet security questionnaire, the Young's Diagnostic questionnaire (YDQ), the Adolescent Computer Addiction Test (ACAT). Results indicated that the Cypriot population had comparable addiction statistics with other Greek-speaking populations in Greece; 15.3% of the students were classified as Internet addicted by their YDQ scores and 16.3% as PC addicted by their ACAT scores. Those results are among the highest in Europe. Our results were alarming and have led to the creation of an Internet and PC addiction prevention program which will focus on high-school professor training and the creation of appropriate prevention material for all high-schools, starting immediately after the conclusion of the pan-Cypriot survey, focusing especially on those areas where the frequency of addictive behaviors will be highest.

  5. Autophagy Regulates Colistin-Induced Apoptosis in PC-12 Cells

    Science.gov (United States)

    Zhang, Ling; Zhao, Yonghao; Ding, Wenjian; Jiang, Guozheng; Lu, Ziyin; Li, Li; Wang, Jinli

    2015-01-01

    Colistin is a cyclic cationic polypeptide antibiotic with activity against multidrug-resistant Gram-negative bacteria. Our recent study demonstrated that colistin induces apoptosis in primary chick cortex neurons and PC-12 cells. Although apoptosis and autophagy have different impacts on cell fate, there is a complex interaction between them. Autophagy plays an important role as a homeostasis regulator by removing excessive or unnecessary proteins and damaged organelles. The aim of the present study was to investigate the modulation of autophagy and apoptosis regulation in PC-12 cells in response to colistin treatment. PC-12 cells were exposed to colistin (125 to 250 μg/ml), and autophagy was detected by visualization of monodansylcadaverine (MDC)-labeled vacuoles, LC3 (microtubule-associated protein 1 light chain 3) immunofluorescence microscopic examination, and Western blotting. Apoptosis was measured by flow cytometry, Hoechst 33258 staining, and Western blotting. Autophagosomes were observed after treatment with colistin for 12 h, and the levels of LC3-II gene expression were determined; observation and protein levels both indicated that colistin induced a high level of autophagy. Colistin treatment also led to apoptosis in PC-12 cells, and the level of caspase-3 expression increased over the 24-h period. Pretreatment of cells with 3-methyladenine (3-MA) increased colistin toxicity in PC-12 cells remarkably. However, rapamycin treatment significantly increased the expression levels of LC3-II and beclin 1 and decreased the rate of apoptosis of PC-12 cells. Our results demonstrate that colistin induced autophagy and apoptosis in PC-12 cells and that the latter was affected by the regulation of autophagy. It is very likely that autophagy plays a protective role in the reduction of colistin-induced cytotoxicity in neurons. PMID:25645826

  6. RECOG-SIZE: Pattern recognition code RECOG-ORNL. [In FORTRAN IV for IBM 360

    Energy Technology Data Exchange (ETDEWEB)

    Begovich, C. L.; Larson, N. M.

    1977-05-01

    RECOG-ORNL is a general-purpose pattern recognition code that is an ORNL modification of the program RECOG, written and implemented at Lawrence Livermore Laboratory. The code contains various pattern recognition methods for data analysis, preprocessing and display of data, plus unsupervised and supervised learning. The algorithms used and the input data required are described for each available option. A sample run is included. An auxiliary program that calculates the array sizes needed for a data set is also listed. 2 figures, 12 tables.

  7. Empirically modelled Pc3 activity based on solar wind parameters

    Directory of Open Access Journals (Sweden)

    B. Heilig

    2010-09-01

    Full Text Available It is known that under certain solar wind (SW/interplanetary magnetic field (IMF conditions (e.g. high SW speed, low cone angle the occurrence of ground-level Pc3–4 pulsations is more likely. In this paper we demonstrate that in the event of anomalously low SW particle density, Pc3 activity is extremely low regardless of otherwise favourable SW speed and cone angle. We re-investigate the SW control of Pc3 pulsation activity through a statistical analysis and two empirical models with emphasis on the influence of SW density on Pc3 activity. We utilise SW and IMF measurements from the OMNI project and ground-based magnetometer measurements from the MM100 array to relate SW and IMF measurements to the occurrence of Pc3 activity. Multiple linear regression and artificial neural network models are used in iterative processes in order to identify sets of SW-based input parameters, which optimally reproduce a set of Pc3 activity data. The inclusion of SW density in the parameter set significantly improves the models. Not only the density itself, but other density related parameters, such as the dynamic pressure of the SW, or the standoff distance of the magnetopause work equally well in the model. The disappearance of Pc3s during low-density events can have at least four reasons according to the existing upstream wave theory: 1. Pausing the ion-cyclotron resonance that generates the upstream ultra low frequency waves in the absence of protons, 2. Weakening of the bow shock that implies less efficient reflection, 3. The SW becomes sub-Alfvénic and hence it is not able to sweep back the waves propagating upstream with the Alfvén-speed, and 4. The increase of the standoff distance of the magnetopause (and of the bow shock. Although the models cannot account for the lack of Pc3s during intervals when the SW density is extremely low, the resulting sets of optimal model inputs support the generation of mid latitude Pc3 activity predominantly through

  8. A microcomputer program for energy assessment and aggregation using the triangular probability distribution

    Science.gov (United States)

    Crovelli, R.A.; Balay, R.H.

    1991-01-01

    A general risk-analysis method was developed for petroleum-resource assessment and other applications. The triangular probability distribution is used as a model with an analytic aggregation methodology based on probability theory rather than Monte-Carlo simulation. Among the advantages of the analytic method are its computational speed and flexibility, and the saving of time and cost on a microcomputer. The input into the model consists of a set of components (e.g. geologic provinces) and, for each component, three potential resource estimates: minimum, most likely (mode), and maximum. Assuming a triangular probability distribution, the mean, standard deviation, and seven fractiles (F100, F95, F75, F50, F25, F5, and F0) are computed for each component, where for example, the probability of more than F95 is equal to 0.95. The components are aggregated by combining the means, standard deviations, and respective fractiles under three possible siutations (1) perfect positive correlation, (2) complete independence, and (3) any degree of dependence between these two polar situations. A package of computer programs named the TRIAGG system was written in the Turbo Pascal 4.0 language for performing the analytic probabilistic methodology. The system consists of a program for processing triangular probability distribution assessments and aggregations, and a separate aggregation routine for aggregating aggregations. The user's documentation and program diskette of the TRIAGG system are available from USGS Open File Services. TRIAGG requires an IBM-PC/XT/AT compatible microcomputer with 256kbyte of main memory, MS-DOS 3.1 or later, either two diskette drives or a fixed disk, and a 132 column printer. A graphics adapter and color display are optional. ?? 1991.

  9. PC based temporary shielding administrative procedure (TSAP)

    Energy Technology Data Exchange (ETDEWEB)

    Olsen, D.E.; Pederson, G.E. [Sargent & Lundy, Chicago, IL (United States); Hamby, P.N. [Commonwealth Edison Co., Downers Grove, IL (United States)

    1995-03-01

    A completely new Administrative Procedure for temporary shielding was developed for use at Commonwealth Edison`s six nuclear stations. This procedure promotes the use of shielding, and addresses industry requirements for the use and control of temporary shielding. The importance of an effective procedure has increased since more temporary shielding is being used as ALARA goals become more ambitious. To help implement the administrative procedure, a personal computer software program was written to incorporate the procedural requirements. This software incorporates the useability of a Windows graphical user interface with extensive help and database features. This combination of a comprehensive administrative procedure and user friendly software promotes the effective use and management of temporary shielding while ensuring that industry requirements are met.

  10. Towards one PC for systems with different security levels

    Science.gov (United States)

    Kleidermacher, David N.; Zimmer, Joerg

    Companies and organisations caring about the protection of critical data or critical systems have long struggled with the burden of maintaining separate computers. Commercial grade operating systems and virtualization solutions such as Windows, Linux, and VMware are unsuitable for security assurance to the high levels required for this kind of application sharing on a single PC platform. Custom solutions have failed to gain acceptance as cost containment pressures favour commercial, off-the-shelf (COTS) platforms. In addition, common PC hardware has had serious security limitations that prevent even a high assurance software solution from achieving the required domain separation. The hope for a truly high assurance, multi-level secure PC is coming closer to reality by virtue of recent innovations, both in software and hardware.

  11. Wind tunnel test on PC cable-stayed bridge; PC shachokyo no taifu seino shiken

    Energy Technology Data Exchange (ETDEWEB)

    Kubo, Y. [Kyushu Inst. of Technology, Kitakyushu (Japan). Faculty of Engineering

    1997-05-30

    This paper describes the wind tunnel test on a PC cable-stayed bridge. The aerodynamic force that acts on a building is represented by the drag that works in the wind direction, the lift that works perpendicularly to the wind direction, and the aerodynamic moment that causes rotation. In the measurement of wind load, a girder is partially extracted in the wind tunnel and set in a three-component balance, and the drag, lift, and aerodynamic moment are measured using a strain meter while blowing the wind. In a wind tunnel experiment, the similarity on Reynolds number, field number, rigidity, hydraulic force, structural attenuation, and reduced wind velocity is required. However, the wind velocity in the actual bridge uses the same air as that in an experiment. The similarity rule on the Reynolds is not thus satisfied. It is necessary to cause no self-excited vibration (galloping and flutter) as wind-resistant performance and suppress the eddy excitation to less than the allowable amplitude. Moreover, the three-dimensional experiment using an elastic model is conducted in addition to the two-dimensional experiment using a rigid model. In the three-dimensional experiment, various vibration modes that occur in the actual bridge appear. 12 refs., 15 figs.

  12. Feature of extradosed PC bridge and its design; Daihenshin keburu PC kyo no tokucho to sono sekkei

    Energy Technology Data Exchange (ETDEWEB)

    Komiya, M. [Japan Bridge and Structure Institute Inc., Tokyo (Japan)

    1997-03-31

    A PC bridge with the eccentricity of the external cable increased by protruding the deviated member to the outside of the beam for more effective use of the external cable is called a `PC bridge with tendons of large eccentricity.` The extradosed bridge of main beam/cable joint type is a PC bridge with the external cable arranged via a tower-shaped eccentric member provided at the intermediate support, and resembles morphologically a cable stayed bridge having a very low tower. There are two types of extradosed bridges, i.e. a type with concrete coated external cable (cable stayed slab bridge) and the other with non-coated external cable (external cable stayed bridge). Features, structural planning and designing of the general external cable stayed bridge are shown. The features are the possession of intermediate characteristics of those of the PC beam bridge and the PC cable stayed bridge from the viewpoints of structural property, workability, economic efficiency, and scenic property. Outline of the plan, selection of structural data, design of the external cable, and structural characteristics in the ultimate state are discussed. 19 refs., 18 figs., 15 tabs.

  13. Realizing broad-bandwidth visible wavelength photodiode based on solution-processed ZnPc/PC71BM dyad

    Science.gov (United States)

    Zafar, Qayyum; Fatima, Noshin; Karimov, Khasan S.; Ahmed, Muhammad M.; Sulaiman, Khaulah

    2017-02-01

    Herein, we demonstrate a solution-processed visible wavelength organic photodiode (OPD) using donor/acceptor dyad of zinc phthalocyanine (ZnPc) and [6,6]-phenyl-C71-butyric-acid methyl ester (PC71BM), respectively. The synergic absorption profiles of both ZnPc and PC71BM moieties have been exploited to realize broader (350 and 800 nm) and consistent absorption spectrum of the photoactive film. The optimum loading ratio (by volume) of D/A dyad has been estimated to be 1:0.8, via quenching phenomenon in ZnPc photoluminescence spectrum. The performance of the OPD has been evaluated by detecting the photocurrent density with respect to varied illumination levels (0-150 mW/cm2) of impinging light at different reverse bias conditions. Under identical reverse bias mode, the photocurrent density has shown significant upsurge as the incident intensity of light is increased; ultimately leading to the significantly higher responsivity (162.4 μA/W) of the fabricated diode. The light to dark current density ratio (Jph/Jd) of the device at 3 V reverse bias has been calculated to be ∼20.12. The transient photocurrent density response of the fabricated OPD has also been characterized at -4 V operational bias under switch ON/OFF illumination. The measured response and recovery time for the fabricated OPD are ∼200 and 300 ms, respectively.

  14. Physical and Mechanical Characteristics of Kevlar Fiber-Reinforced PC/ABS Composites

    OpenAIRE

    Kuljira Sujirote; Parkpoom Lorjai; Sarawut Rimdusit; Sunan Tiptipakorn

    2012-01-01

    In this research, the composites between polycarbonate (PC) and acrylonitrile-butadiene-styrene (ABS) alloy and Kevlar fiber were prepared. The flexural and tensile properties of PC/ABS alloy and its composites were determined using a universal testing machine. The synergistic behavior of flexural modulus was observed for all regions of PC contents, while the synergism of flexural strength and tensile strength were found in some PC contents. It was found that the optimum weight ratio of PC:AB...

  15. The Local White Dwarf Population: The 25 pc Sample

    Science.gov (United States)

    Holberg, Jay B.; Sion, E. M.; Oswalt, T. D.

    2011-01-01

    Currently the most complete sample of white dwarf stars comes from the local white dwarf population within 20 pc, which is believed to be 80 percent complete. This sample contains some 132 degenerate stars. We hope to effectively double the number of known local white dwarfs by extending the sample boundary to 25 pc, while still maintaining a high level of completeness. We discuss plans for extending the local sample and some of the studies that will be possible with this enlarged population. This work was funded in part by NSF Grant AST-1008845.

  16. Data Communication PC/NaI-borehole probe (Hardware & Software)

    DEFF Research Database (Denmark)

    Madsen, Peter Buch

    Development of new hard- & software to a NaI borehole probe on a PC. Save data from the probe each 10'th sec, handle the data from the probe and make calculations every 10'th sec and show the results on the monitor.......Development of new hard- & software to a NaI borehole probe on a PC. Save data from the probe each 10'th sec, handle the data from the probe and make calculations every 10'th sec and show the results on the monitor....

  17. Ada (Trade Name) Compiler Validation Summary Report: Alsys Inc., AlsyCOMP 019, V3.0.1, IBM PC At Host, Intel iSBC 286/14 Target.

    Science.gov (United States)

    1988-06-19

    language constructs and that it identifies and rejects illegal language constructs. The testing also identifies behaviour that is implementation dependent...the implementation-dependent behaviour is allowed by the Ada Standard Testing of this compiler was conducted by NCC under the direction of the AVF...accurate and complete, or that the subject compiler has no nonconformities to the Ada Standard other than those presented. Copies of this report are

  18. TS-SRP/PACK - COMPUTER PROGRAMS TO CHARACTERIZE ALLOYS AND PREDICT CYCLIC LIFE USING THE TOTAL STRAIN VERSION OF STRAINRANGE PARTITIONING

    Science.gov (United States)

    Saltsman, J. F.

    1994-01-01

    TS-SRP/PACK is a set of computer programs for characterizing and predicting fatigue and creep-fatigue resistance of metallic materials in the high-temperature, long-life regime for isothermal and nonisothermal fatigue. The programs use the total strain version of the Strainrange Partitioning (TS-SRP). The user should be thoroughly familiar with the TS-SRP method before attempting to use any of these programs. The document for this program includes a theory manual as well as a detailed user's manual with a tutorial to guide the user in the proper use of TS-SRP. An extensive database has also been developed in a parallel effort. This database is an excellent source of high-temperature, creep-fatigue test data and can be used with other life-prediction methods as well. Five programs are included in TS-SRP/PACK along with the alloy database. The TABLE program is used to print the datasets, which are in NAMELIST format, in a reader friendly format. INDATA is used to create new datasets or add to existing ones. The FAIL program is used to characterize the failure behavior of an alloy as given by the constants in the strainrange-life relations used by the total strain version of SRP (TS-SRP) and the inelastic strainrange-based version of SRP. The program FLOW is used to characterize the flow behavior (the constitutive response) of an alloy as given by the constants in the flow equations used by TS-SRP. Finally, LIFE is used to predict the life of a specified cycle, using the constants characterizing failure and flow behavior determined by FAIL and FLOW. LIFE is written in interpretive BASIC to avoid compiling and linking every time the equation constants are changed. Four out of five programs in this package are written in FORTRAN 77 for IBM PC series and compatible computers running MS-DOS and are designed to read data using the NAMELIST format statement. The fifth is written in BASIC version 3.0 for IBM PC series and compatible computers running MS-DOS version 3.10. The

  19. IBM i5iSeries Primer Concepts and Techniques for Programmers, Administrators, and System Operators

    CERN Document Server

    Forsythe, Kevin; Holt, Ted; Pence, Doug

    2012-01-01

    This comprehensive, 35-chapter book is the ultimate resource and a "must-have" for every professional working with the i5/iSeries. It is perfect for novice and intermediate programmers as well as for system administrators and operators. In simple, straightforward style, the authors explain core i5/iSeries concepts and show you step by step how to perform a wide variety of essential functions. The book includes sections on installation, operations, administration, system architecture, programming, the Internet, and troubleshooting. These sections are organized in free-standing style so you d

  20. Quality assessment of platelet concentrates prepared by platelet rich plasma-platelet concentrate, buffy coat poor-platelet concentrate (BC-PC and apheresis-PC methods

    Directory of Open Access Journals (Sweden)

    Singh Ravindra

    2009-01-01

    Full Text Available Background: Platelet rich plasma-platelet concentrate (PRP-PC, buffy coat poor-platelet concentrate (BC-PC, and apheresis-PC were prepared and their quality parameters were assessed. Study Design: In this study, the following platelet products were prepared: from random donor platelets (i platelet rich plasma - platelet concentrate (PRP-PC, and (ii buffy coat poor- platelet concentrate (BC-PC and (iii single donor platelets (apheresis-PC by different methods. Their quality was assessed using the following parameters: swirling, volume of the platelet concentrate, platelet count, WBC count and pH. Results: A total of 146 platelet concentrates (64 of PRP-PC, 62 of BC-PC and 20 of apheresis-PC were enrolled in this study. The mean volume of PRP-PC, BC-PC and apheresis-PC was 62.30±22.68 ml, 68.81±22.95 ml and 214.05±9.91 ml and ranged from 22-135 ml, 32-133 ml and 200-251 ml respectively. The mean platelet count of PRP-PC, BC-PC and apheresis-PC was 7.6±2.97 x 1010/unit, 7.3±2.98 x 1010/unit and 4.13±1.32 x 1011/unit and ranged from 3.2-16.2 x 1010/unit, 0.6-16.4 x 1010/unit and 1.22-8.9 x 1011/unit respectively. The mean WBC count in PRP-PC (n = 10, BC-PC (n = 10 and apheresis-PC (n = 6 units was 4.05±0.48 x 107/unit, 2.08±0.39 x 107/unit and 4.8±0.8 x 106/unit and ranged from 3.4 -4.77 x 107/unit, 1.6-2.7 x 107/unit and 3.2 - 5.2 x 106/unit respectively. A total of 26 units were analyzed for pH changes. Out of these units, 10 each were PRP-PC and BC-PC and 6 units were apheresis-PC. Their mean pH was 6.7±0.26 (mean±SD and ranged from 6.5 - 7.0 and no difference was observed among all three types of platelet concentrate. Conclusion: PRP-PC and BC-PC units were comparable in terms of swirling, platelet count per unit and pH. As expected, we found WBC contamination to be less in BC-PC than PRP-PC units. Variation in volume was more in BC-PC than PRP-PC units and this suggests that further standardization is required for preparation of BC-PC

  1. Conceptual Design of Oxygen-Based PC Boiler

    Energy Technology Data Exchange (ETDEWEB)

    Andrew Seltzer; Zhen Fan

    2005-09-01

    {sub 2} rich stream for sequestration. FW has developed a conceptual design of an O{sub 2} fired boiler to determine overall plant performance and economics. Five subtasks were conducted: (1) a literature review, (2) a system design and analysis, (3) a low NOx burner design and analysis, (4) a furnace and heat recovery area design analysis, and (5) an economic analysis. The objective of the literature search is to locate any data/information relevant to the Oxygen-Based PC Boiler conceptual design. The objective of the system design and analysis task is to optimize the PC boiler plant by maximizing system efficiency within practical considerations. Simulations of the oxygen-fired plant with CO{sub 2} sequestration were conducted using Aspen Plus and were compared to a reference air-fired 460 MW plant. Flue gas recycle is used in the O{sub 2}-fired PC to control the flame temperature. Parametric runs were made to determine the effect of flame temperature on system efficiency and required waterwall material and thickness. The degree of improvement on system efficiency of various modifications including hot gas recycle, purge gas recycle, flue gas feedwater recuperation, and recycle purge gas expansion were investigated. The selected O{sub 2}-fired design case has a system efficiency of 30.6% compared to the air-fired system efficiency of 36.7%. The design O{sub 2}-fired case requires T91 waterwall material and has a waterwall surface area of only 65% of the air-fired reference case. The objective of the low NOx burner design and analysis task is to optimize the burner design to ensure stable ignition, to provide safe operation, and to minimize pollutant formation. The burners were designed and analyzed using the Fluent CFD computer program. Four burner designs were developed: (1) with no OFG and 65% flue gas recycle, (2) with 20% OFG and 65% flue gas recycle, (3) with no OFG and 56% flue gas recycle and (4) with 20% OFG and 56% flue gas recycle. A 3-D Fluent simulation was

  2. Molecular cloning and expression of prohormone convertases PC1 and PC2 in the pituitary gland of the bullfrog, Rana catesbeiana.

    Science.gov (United States)

    Yaoi, Yuichi; Suzuki, Masakazu; Tomura, Hideaki; Kikuyama, Sakae; Tanaka, Shigeyasu

    2003-09-01

    We cloned cDNAs encoding PC1 and PC2 from a cDNA library constructed for the anterior pituitary gland of the bullfrog (Rana catesbeiana) and sequenced them. The bullfrog PC1 cDNA consisted of 2972 base pairs (bp) with an open reading frame of 2208 bp and encoded a protein of 736 amino acids, including a putative signal peptide of 26 amino acids. The protein showed a high homology to R. ridibunda PC1 (95.1%) and mammalian PC1 (72.6%). The bullfrog PC2 cDNA consisted of 2242 bp with an open reading frame of 1914 bp and encoded a protein of 638 amino acids, including a putative signal peptide of 23 amino acids. This protein showed a high homology to R. ridibunda PC2 (95.5%) and mammalian PC2 (84.8%). The catalytic triad of serine proteinases of the subtilisin family was found at Asp-168, His-209, and Ser-383 in the PC1 protein and at Asp-167, His-208, and Ser-384 in the PC2 protein. In situ hybridization staining revealed that PC2 mRNA was detected in corticotrope cells of the tadpoles, but not in those of the adults. In the adult, only PC1 mRNA was detected in the pars distalis but both PC1 and PC2 mRNAs were detected in the pars intermedia. The data also showed that PC1 mRNA was expressed in gonadotrope cells.

  3. Charge transfer at F{sub 16}CoPc and CoPc interfaces to Au

    Energy Technology Data Exchange (ETDEWEB)

    Lindner, Susi; Treske, Uwe; Grobosch, Mandy; Knupfer, Martin [IFW Dresden (Germany)

    2011-12-15

    We analyze the electronic properties of the interfaces between cobalt phthalocyanine (CoPc), as well as fluorinated cobalt phthalocyanine (F{sub 16}CoPc), and an Au(100) single-crystal using X-ray photoemission spectroscopy and valence band ultraviolet photoemission spectroscopy. Our data demonstrate that for the monolayers of both materials a charge transfer occurs from the substrate to the center of the organic molecules resulting in a central Co(I) ion. This leads to the conclusion that this effect essentially is fluorination- and ligand-independent. (orig.)

  4. Application of sPC-SAFT and group contribution sPC-SAFT to polymer systems-Capabilities and limitations

    DEFF Research Database (Denmark)

    Tihic, Amra; von Solms, Nicolas; Michelsen, Michael Locht

    2009-01-01

    PC-SAFT model, with and without GC. The reported results contribute to a better understanding of the applicability of the sPC-SAFT model to binary polymer mixtures, and identify both models as good predictive tools for several industrial applications. Limitations are also identified and discussed....... predictive capability of the model demonstrates satisfactory description of the fluid behaviour of several polymer systems, including both vapour-liquid equilibria and liquid-liquid equilibria. This work continues the systematic study on phase behaviour of polymer systems with the two versions of the s...

  5. Porphyrin-phthalocyanine nanorods (P-PcNR) formed by ...

    African Journals Online (AJOL)

    ... tetra {2,(3)-(2-mercaptopyridine) phthalocyaninato}(MTSPyPc). The transmission electron microscope (TEM) images of the colloid suspension of the aggregate confirmed formation of nanorods while their electron spectra showed that the molecules formed J-aggregation. Keywords: Porphyrin, Phthalocyanine, Nanorods, ...

  6. Level of personal computer (PC) tablet penetration among ...

    African Journals Online (AJOL)

    This study was designed to find out level of Personal Computer (PC) tablet penetration among undergraduate students of university of Ilorin, Ilorin, Nigeria. Random sampling technique was adopted to select 200 students from selected Faculties in University of Ilorin. The questionnaire were administered, collected and ...

  7. Comparison between a newly developed PC-based Doppler ...

    African Journals Online (AJOL)

    Objectives. To determine the accuracy of the resistance index (RI) of flow velocity waveforms of the umbilical artery measured using a newly developed PC-based continuous wave Doppler device (Umbiflow) with regard to systematic and random variations when compared with a commercial standard (Vasoflow). Design.

  8. Privacy Impact Assessment for the PC Label System

    Science.gov (United States)

    The PC Label System collects contact information for individuals with an interest in EPA's Region 1. Learn how this data will be collected in the system, how it will be used, access to the data, the purpose of data collection, and record retention policies

  9. A PC-based Workstation for Robotic Discectomy

    Science.gov (United States)

    Casadei, C.; Fiorini, P.; Martelli, S.; Montanari, M.; Morri, A.

    1998-01-01

    Ths paper describes a PC-based controller for robot-assisted minimally invasive surgery. The development is motivated by the need of reducing the exposure of operating room personnel to X-rays during surgical procedures such as percutanrous discectomy.

  10. Photodynamic inactivation of Candida albicans by BAM-SiPc.

    Science.gov (United States)

    So, Cheung-Wai; Tsang, Paul W K; Lo, Pui-Chi; Seneviratne, C J; Samaranayake, Lakshman P; Fong, Wing-Ping

    2010-05-01

    Photodynamic therapy is a treatment that combines the use of three non-toxic components, viz. photosensitiser, light and oxygen to cause localised oxidative photodamage. In the present study, the antifungal effect of the photosensitiser, BAM-SiPc, an unsymmetrical bisamino phthalocyanine, was investigated. BAM-SiPc was effective in photo-inactivating Candida albicans in a dose-dependent manner. The cell viability as determined by the clonogenic assay was reduced to c. 10% at 0.02 micromol l(-1) BAM-SiPc with a total fluence of 12 J cm(-2) at a cell density of 10(7) cells ml(-1). A short incubation time of 5-15 min was sufficient to allow the photosensitiser to exert its optimal antifungal activity. Microscopical analysis showed that BAM-SiPc was effectively internalised by the fungal cells. Photodynamic treatment led to an increase in the intracellular reactive oxygen species level and disturbed the membrane integrity of the fungal cells.

  11. A compulation program for numerical filtering

    Directory of Open Access Journals (Sweden)

    V. GUERRIERI

    1968-06-01

    Full Text Available A computation program, written in FORTRAN IV
    language, for numerical filtering of time series is described. It was tested
    with an IBM 7094/7040 DCS computer.
    The numerical filtering operation allows to extract or suppress in a
    time series prefixed frequency waves indipendently by the change of phases
    and wideness with which they can appear

  12. Microscopic description of the even-even 140-148Ba isotopes using BM, IBM and IVBM

    Science.gov (United States)

    Ahmed, Imad M.; Flaiyh, Ghaith N.; Kassim, Huda H.; Abdullah, Hewa Y.; Hossain, I.; Sharrad, Fadhil I.

    2017-02-01

    A description of the even-even Ba isotopes for A = 140 to 148 in framework of Bohr-Mottelson model, interacting boson model and interacting vector boson model are carried out. The E-GOS curve ( E γ/ I and the ratio between the energies of the ( I + 2) and ( I) states ( r( I + 2)/ I) as a function of the spin ( I have been drawn to determine the property of the ground-state band. The positive ground-state band of 140-148Ba has been calculated using Bohr-Mottelson model, interacting boson model and interacting vector boson model, while the negative-parity band of 140-148Ba has been calculated using Bohr-Mottelson model and interacting vector boson model only. The reduced transition probabilities B( E2) of these nuclei were calculated. The parameters of the best fit to the measured data are determined. The potential energy surfaces (PESs) to the IBM Hamiltonian have been obtained using the intrinsic coherent state.

  13. Quantitative Trait Locus Analysis for Deep-Sowing Germination Ability in the Maize IBM Syn10 DH Population.

    Science.gov (United States)

    Liu, Hongjun; Zhang, Lin; Wang, Jiechen; Li, Changsheng; Zeng, Xing; Xie, Shupeng; Zhang, Yongzhong; Liu, Sisi; Hu, Songlin; Wang, Jianhua; Lee, Michael; Lübberstedt, Thomas; Zhao, Guangwu

    2017-01-01

    Deep-sowing is an effective measure to ensure seeds absorbing water from deep soil layer and emerging normally in arid and semiarid regions. However, existing varieties demonstrate poor germination ability in deep soil layer and some key quantitative trait loci (QTL) or genes related to deep-sowing germination ability remain to be identified and analyzed. In this study, a high-resolution genetic map based on 280 lines of the intermated B73 × Mo17 (IBM) Syn10 doubled haploid (DH) population which comprised 6618 bin markers was used for the QTL analysis of deep-sowing germination related traits. The results showed significant differences in germination related traits under deep-sowing condition (12.5 cm) and standard-germination condition (2 cm) between two parental lines. In total, 8, 11, 13, 15, and 18 QTL for germination rate, seedling length, mesocotyl length, plumule length, and coleoptile length were detected for the two sowing conditions, respectively. These QTL explained 2.51-7.8% of the phenotypic variance with LOD scores ranging from 2.52 to 7.13. Additionally, 32 overlapping QTL formed 11 QTL clusters on all chromosomes except for chromosome 8, indicating the minor effect genes have a pleiotropic role in regulating various traits. Furthermore, we identified six candidate genes related to deep-sowing germination ability, which were co-located in the cluster regions. The results provide a basis for molecular marker assisted breeding and functional study in deep-sowing germination ability of maize.

  14. The Redox-Active Chromium Phthalocyanine System: Isolation of Five Oxidation States from Pc(4-) Cr(I) to Pc(2-) Cr(III).

    Science.gov (United States)

    Zhou, Wen; Thompson, John R; Leznoff, Clifford C; Leznoff, Daniel B

    2017-02-16

    The preparation and structural characterization of a series of chromium phthalocyanine complexes with multiple metal and ring oxidation states were achieved using PcCr(II) (1) (Pc=phthalocyanine) or PcCr(II) (THF)2 (1⋅THF2 ) as starting materials. The reaction of soluble 1⋅THF2 with Br2 or I2 gave the PcCr(III) halide complexes PcCrX(THF) (X=I/I3 , Br; 3, 4, respectively). Treatment of 1 with 0.5 equivalent of PhIO or air generated the dinuclear [PcCr(THF)]2 (μ-O) (5), whereas the addition of one equivalent of AgSbF6 to 1 resulted in oxidation to THF-solvated octahedral [PcCr(III) (THF)2 ]SbF6 (6). The reduction of 1 with three sequential equivalents of KEt3 BH resulted in the isolation of [K(DME)4 ][Pc(3-) Cr(II) ] (7), [K(DME)4 ]2 [Pc(4-) Cr(II) ] (8) and [K6 (DME)4 ][Pc(4-) Cr(I) ]2 (9), respectively. The reduced products are deep purple in colour, with visible absorption maxima between 500-580 nm. The ring-reduced complexes 7 and 8 are monomeric, whereas 9 is a 1D chain of dinuclear [PcCr]2 units with intercalated K(+) cations and supported by Cr-Cr interactions of 2.988(2) Å. Addition of four equivalents of KC8 resulted in the demetallated product PcK2 (DME)4 (10), which has a 1D chain structure. The isolation and structural characterization of new PcCr complexes spanning five oxidation states, including rare examples of crystalline reduced Pc-ring species emphasizes the broad redox activity and stability of phthalocyanine-based complexes. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  15. AmbCare--A Relational Database for Implementing a Community Pharmacy Ambulatory Care Teaching Program: A Descriptive Report.

    Science.gov (United States)

    Magarian, Edward O.; Peterson, Charles D.

    1995-01-01

    An IBM-compatible information storage and retrieval software program was developed to support an eight-week community pharmacy ambulatory care clerkship for entry-level Doctor of Pharmacy students. The program helps evaluate and identify patients for health and medication problems, perform patient risk-factor assessment, monitor drug therapy,…

  16. Sample problems for the novice user of the AMPX-II system. [For generating coupled multigroup neutron--gamma libraries, in FORTRAN IV for IBM 360/91

    Energy Technology Data Exchange (ETDEWEB)

    Ford, W.E. III; Roussin, R.W.; Petrie, L.M.; Diggs, B.R.; Comolander, H.E.

    1979-01-01

    Contents of the IBM version of the APMX system distributed by the Radiation Shielding Information Center (APMX-II) are described. Sample problems which demonstrate the procedure for implementing AMPX-II modules to generate point cross sections; generate multigroup neutron, photon production, and photon interaction cross sections for various transport codes; collapse multigroup cross sections; check, edit, and punch multigroup cross sections; and execute a one-dimensional discrete ordinates transport calculation are detailed. 25 figures, 9 tables.

  17. Artificial intelligence in neurodegenerative disease research: use of IBM Watson to identify additional RNA-binding proteins altered in amyotrophic lateral sclerosis.

    Science.gov (United States)

    Bakkar, Nadine; Kovalik, Tina; Lorenzini, Ileana; Spangler, Scott; Lacoste, Alix; Sponaugle, Kyle; Ferrante, Philip; Argentinis, Elenee; Sattler, Rita; Bowser, Robert

    2018-02-01

    Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease with no effective treatments. Numerous RNA-binding proteins (RBPs) have been shown to be altered in ALS, with mutations in 11 RBPs causing familial forms of the disease, and 6 more RBPs showing abnormal expression/distribution in ALS albeit without any known mutations. RBP dysregulation is widely accepted as a contributing factor in ALS pathobiology. There are at least 1542 RBPs in the human genome; therefore, other unidentified RBPs may also be linked to the pathogenesis of ALS. We used IBM Watson ® to sieve through all RBPs in the genome and identify new RBPs linked to ALS (ALS-RBPs). IBM Watson extracted features from published literature to create semantic similarities and identify new connections between entities of interest. IBM Watson analyzed all published abstracts of previously known ALS-RBPs, and applied that text-based knowledge to all RBPs in the genome, ranking them by semantic similarity to the known set. We then validated the Watson top-ten-ranked RBPs at the protein and RNA levels in tissues from ALS and non-neurological disease controls, as well as in patient-derived induced pluripotent stem cells. 5 RBPs previously unlinked to ALS, hnRNPU, Syncrip, RBMS3, Caprin-1 and NUPL2, showed significant alterations in ALS compared to controls. Overall, we successfully used IBM Watson to help identify additional RBPs altered in ALS, highlighting the use of artificial intelligence tools to accelerate scientific discovery in ALS and possibly other complex neurological disorders.

  18. METHANE de-NOX for Utility PC Boilers

    Energy Technology Data Exchange (ETDEWEB)

    Bruce Bryan; Serguei Nester; Joseph Rabovitser; Stan Wohadlo

    2005-09-30

    The overall project objective is the development and validation of an innovative combustion system, based on a novel coal preheating concept prior to combustion, that can reduce NO{sub x} emissions to 0.15 lb/million Btu or less on utility pulverized coal (PC) boilers. This NO{sub x} reduction should be achieved without loss of boiler efficiency or operating stability, and at more than 25% lower levelized cost than state-of-the-art SCR technology. A further objective is to ready technology for full-scale commercial deployment to meet the market demand for NO{sub x} reduction technologies. Over half of the electric power generated in the U.S. is produced by coal combustion, and more than 80% of these units utilize PC combustion technology. Conventional measures for NOx reduction in PC combustion processes rely on combustion and post-combustion modifications. A variety of combustion-based NO{sub x} reduction technologies are in use today, including low-NO{sub x} burners (LNBs), flue gas recirculation (FGR), air staging, and natural gas or other fuel reburning. Selective non-catalytic reduction (SNCR) and selective catalytic reduction (SCR) are post-combustion techniques. NO{sub x} reduction effectiveness from these technologies ranges from 30 to 60% and up to 90-93% for SCR. Typically, older wall-fired PC burner units produce NO{sub x} emissions in the range of 0.8-1.6 lb/million Btu. Low-NO{sub x} burner systems, using combinations of fuel staging within the burner and air staging by introduction of overfire air in the boiler, can reduce NO{sub x} emissions by 50-60%. This approach alone is not sufficient to meet the desired 0.15 lb/million Btu NO{sub x} standard with a range of coals and boiler loads. Furthermore, the heavy reliance on overfire air can lead to increased slagging and corrosion in furnaces, particularly with higher-sulfur coals, when LNBs are operated at sub-stoichiometric conditions to reduce fuel-derived NOx in the flame. Therefore, it is desirable

  19. Frequency of autoantibodies and correlation with HLA-DRB1 genotype in sporadic inclusion body myositis (s-IBM): a population control study.

    Science.gov (United States)

    Rojana-Udomsart, Arada; Bundell, Christine; James, Ian; Castley, Alison; Martinez, Patricia; Christiansen, Frank; Hollingsworth, Peter; Mastaglia, Frank

    2012-08-15

    The frequency of myositis-associated and myositis-specific autoantibodies (AAb) was compared in 51 s-IBM patients and a population control group. Non-organ specific AAb (ANA, anti-Ro52, anti-Ro60, anti-La, anti-RNP) but not anti-thyroid peroxidase, anti-tissue transglutaminase or myositis-specific antibodies, were more frequent in s-IBM patients, and 14/51 (27%) had another autoimmune disease (Sjögren's syndrome, thyroiditis, psoriasis, vitiligo). The presence of AAb did not correlate with carriage of HLA-DRB1*0301, but there was a negative correlation between ANA/anti-Ro52 and carriage of HLA-DRB1*1301. The findings in this cohort confirm that patients with sIBM do not show evidence of a muscle-specific humoral immune process but have an increased frequency of non-organ specific AAb and other autoimmune disorders. Copyright © 2012 Elsevier B.V. All rights reserved.

  20. High-resolution HLA-DRB1 genotyping in an Australian inclusion body myositis (s-IBM) cohort: an analysis of disease-associated alleles and diplotypes.

    Science.gov (United States)

    Rojana-udomsart, Arada; James, Ian; Castley, Alison; Needham, Merrilee; Scott, Adrian; Day, Timothy; Kiers, Lynette; Corbett, Alastair; Sue, Carolyn; Witt, Campbell; Martinez, Patricia; Christiansen, Frank; Mastaglia, Frank

    2012-09-15

    We performed high-resolution (4-digit) HLA-DRB1 genotyping in an Australian cohort of 105s-IBM patients and 189 controls. Our findings showed that whilst the strongest association was with the HLA-DRB1*03:01 allele and the HLA-DRB1*03:01/*01:01 diplotype, HLA-DRB1*01:01 and HLA-DRB1*13:01 are also risk alleles. A number of other alleles, HLA-DRB1*04:01, *04:04, *07:01, *09:01, *11:01 and *15:01, as well as the HLA-DRB1*03:01/*04:01 and HLA-DRB1*03:01/*07:01 diplotypes were reduced in s-IBM cases and may be protective. The HLA-DRB1*03:01 and HLA-DRB1*13:01 alleles also appear to have an influence on the age at onset of the disease and severity of muscle weakness. Our findings indicate that the influence of HLA-DRB1 in s-IBM is complex and that epistatic interactions at the HLA-DRB1 locus contribute both to disease susceptibility and to the clinical phenotype. Copyright © 2012 Elsevier B.V. All rights reserved.

  1. Mapping of QTL for resistance to the Mediterranean corn borer attack using the intermated B73 x Mo17 (IBM) population of maize.

    Science.gov (United States)

    Ordas, Bernardo; Malvar, Rosa A; Santiago, Rogelio; Sandoya, German; Romay, Maria C; Butron, Ana

    2009-11-01

    The Mediterranean corn borer or pink stem borer (MCB, Sesamia nonagrioides Lefebvre) causes important yield losses as a consequence of stalk tunneling and direct kernel damage. B73 and Mo17 are the source of the most commercial valuable maize inbred lines in temperate zones, while the intermated B73 x Mo17 (IBM) population is an invaluable source for QTL identification. However, no or few experiments have been carried out to detect QTL for corn borer resistance in the B73 x Mo17 population. The objective of this work was to locate QTL for resistance to stem tunneling and kernel damage by MCB in the IBM population. We detected a QTL for kernel damage at bin 8.05, although the effect was small and two QTL for stalk tunneling at bins 1.06 and 9.04 in which the additive effects were 4 cm, approximately. The two QTL detected for MCB resistance were close to other QTL consistently found for European corn borer (ECB, Ostrinia nubilalis Hübner) resistance, indicating mechanisms of resistance common to both pests or gene clusters controlling resistance to different plagues. The precise mapping achieved with the IBM population will facilitate the QTL pyramiding and the positional cloning of the detected QTL.

  2. 23rd April 2008 - Nobel Prize in Physics 1987 J. G. Bednorz visiting the LHC tunnel at Point 1 with IBM Zurich Research Laboratory colleagues guided by L. Bottura, N. Catalan Lasheras and Y. Papaphilippou.

    CERN Multimedia

    Maximilien brice

    2008-01-01

    23rd April 2008 - Nobel Prize in Physics 1987 J. G. Bednorz visiting the LHC tunnel at Point 1 with IBM Zurich Research Laboratory colleagues guided by L. Bottura, N. Catalan Lasheras and Y. Papaphilippou.

  3. Sistem Akuisisi Data Multiplatform Berbasis PC dengan Tampilan Hasil di Twitter

    Directory of Open Access Journals (Sweden)

    Arief Hendra Saptadi

    2015-12-01

    Full Text Available Computer or Personal Computer (PC based data acquisition system had enabled the measurement of physical parameters, not only to display and store them in the computer but also to send them to a website. Twitter as one of web services for social media that provides the facility to display 140-character length of text status has been deemed sufficient for the purpose of displaying the latest data and is accessible through available Application Programming Interface (API. The purpose of this research is to design a PC-based data acquisition system which is capable to conduct measurement, storage and transmission of data to the web service via Twitter API. The proposed system was consisted of LM35 temperature sensor to measure room temperature, Arduino Nano microcontroller and a data acquisition application in PC to display and store data in a Comma-Separated Values (CSV file. Based on test results for processes involving Analog to Digital Converter (ADC, the obtained error is 3.71% for voltage value and the average difference between measured values and displayed ones is 0.01 V. Average error for temperature measurement is 5.13% and the difference between measured values and the displayed ones is 1.34°C. Built application had produced an adequate display of interface and fulfilled all required functionalities. Average response time of Twitter API to Choreo is 0.18 s while average time to transmit data from application to Twitter is 2.15 s or 11.75 times longer. In later development, LM35 should be replaced with a more precise sensor. The occurrence of randomness in measurement results could be minimized by adding an active filter circuit between sensor and microcontroller.

  4. PC and monitor night status: Power management enabling and manual turn-off

    Energy Technology Data Exchange (ETDEWEB)

    Nordman, Bruce; Meier, Alan; Piette, Mary Ann

    1998-07-30

    While office equipment accounts for about 7 percent of commercial building energy use, this reflects considerable energy savings from the use of automatic power management. Most of these savings were gained through the use of low-power modes that meet the criteria of the U.S. EPA's Energy Star program. Despite this success, there are large amounts of additional savings that could be gained if all equipment capable of power management use were enabled and functioning. A considerable portion of equipment is not enabled for power management at all, enabled only partially, or is enabled but prevented from functioning. Additional savings could be gained if more equipment were turned off at night manually. We compiled results from 17 studies from the office equipment literature addressing PCs and monitors. Some factors important for annual energy use, such as power levels, have been documented elsewhere and are not covered. We review methods for estimating office equipment use patterns and energy use, and present findings on night status--power management and manual turn-off rates. In early studies, PC power management was often found to function in 25 percent or less of the Energy Star compliant units (10 percent of all PCs). However, recent assessments have found higher rates, and we estimate that for Energy Star models, 35 percent of PC CPUs and 65 percent of PC monitors are enabled for power management. While the data lack statistical rigor, they can be used to estimate the magnitude of current and potential power management savings, which we did for major types of office equipment. The data also make clear that the topic of enabling rates, and the factors which influence them, deserve greater scrutiny.

  5. High Performance Object-Oriented Scientific Programming in Fortran 90

    Science.gov (United States)

    Norton, Charles D.; Decyk, Viktor K.; Szymanski, Boleslaw K.

    1997-01-01

    We illustrate how Fortran 90 supports object-oriented concepts by example of plasma particle computations on the IBM SP. Our experience shows that Fortran 90 and object-oriented methodology give high performance while providing a bridge from Fortran 77 legacy codes to modern programming principles. All of our object-oriented Fortran 90 codes execute more quickly thatn the equeivalent C++ versions, yet the abstraction modelling capabilities used for scentific programming are comparably powereful.

  6. Evaluation of Manual Spelling, Observational and Incidental Learning Using Computer-Based Instruction with a Tablet PC, Large Screen Projection, and a Forward Chaining Procedure

    Science.gov (United States)

    Purrazzella, Kimberly; Mechling, Linda C.

    2013-01-01

    The study employed a multiple probe design to investigate the effects of computer-based instruction (CBI) and a forward chaining procedure to teach manual spelling of words to three young adults with moderate intellectual disability in a small group arrangement. The computer-based program included a tablet PC whereby students wrote words directly…

  7. Tablet PC Enabled Body Sensor System for Rural Telehealth Applications

    Directory of Open Access Journals (Sweden)

    Nitha V. Panicker

    2016-01-01

    Full Text Available Telehealth systems benefit from the rapid growth of mobile communication technology for measuring physiological signals. Development and validation of a tablet PC enabled noninvasive body sensor system for rural telehealth application are discussed in this paper. This system includes real time continuous collection of physiological parameters (blood pressure, pulse rate, and temperature and fall detection of a patient with the help of a body sensor unit and wireless transmission of the acquired information to a tablet PC handled by the medical staff in a Primary Health Center (PHC. Abnormal conditions are automatically identified and alert messages are given to the medical officer in real time. Clinical validation is performed in a real environment and found to be successful. Bland-Altman analysis is carried out to validate the wrist blood pressure sensor used. The system works well for all measurements.

  8. Performance Evaluation of a Multipurpose Bare PC Gateway

    DEFF Research Database (Denmark)

    Tsetse, Anthony; Appiah-Kubi, Patrick; Loukili, Alae

    2015-01-01

    . Different solutions (6to4 tunneling, IVI translation, NAT64, DNS64 etc.), have being proposed but these are all standalone systems. In this paper we discuss the design,implementation and performance evaluation of a multipurpose Bare PC Gateway which incorporates Network Address translation (NAT), 6to4...... tunneling and IVI translation in a single “box” using Bare Machine Computing Paradigm. Experimental testing of the designed system shows our single point integrated system performs well using various measurement metrics as throughput, response time, connection time, jitter etc. in a LAN environment. Our...... results indicate a relatively better performance (18%-45%) of the Bare PC gateway compared to a Linux gateway (running the functionalities as standalone systems). We believe the proposed solution could easily scale to wide area networks and also provide a cost efficient solution...

  9. Flexible missile autopilot design studies with PC-MATLAB/386

    Science.gov (United States)

    Ruth, Michael J.

    1989-01-01

    Development of a responsive, high-bandwidth missile autopilot for airframes which have structural modes of unusually low frequency presents a challenging design task. Such systems are viable candidates for modern, state-space control design methods. The PC-MATLAB interactive software package provides an environment well-suited to the development of candidate linear control laws for flexible missile autopilots. The strengths of MATLAB include: (1) exceptionally high speed (MATLAB's version for 80386-based PC's offers benchmarks approaching minicomputer and mainframe performance); (2) ability to handle large design models of several hundred degrees of freedom, if necessary; and (3) broad extensibility through user-defined functions. To characterize MATLAB capabilities, a simplified design example is presented. This involves interactive definition of an observer-based state-space compensator for a flexible missile autopilot design task. MATLAB capabilities and limitations, in the context of this design task, are then summarized.

  10. PC analysis of stochastic differential equations driven by Wiener noise

    KAUST Repository

    Le Maitre, Olivier

    2015-03-01

    A polynomial chaos (PC) analysis with stochastic expansion coefficients is proposed for stochastic differential equations driven by additive or multiplicative Wiener noise. It is shown that for this setting, a Galerkin formalism naturally leads to the definition of a hierarchy of stochastic differential equations governing the evolution of the PC modes. Under the mild assumption that the Wiener and uncertain parameters can be treated as independent random variables, it is also shown that the Galerkin formalism naturally separates parametric uncertainty and stochastic forcing dependences. This enables us to perform an orthogonal decomposition of the process variance, and consequently identify contributions arising from the uncertainty in parameters, the stochastic forcing, and a coupled term. Insight gained from this decomposition is illustrated in light of implementation to simplified linear and non-linear problems; the case of a stochastic bifurcation is also considered.

  11. Pocket PC-based portable gamma-ray spectrometer

    Directory of Open Access Journals (Sweden)

    Kamontip Ploykrachang

    2011-04-01

    Full Text Available A portable gamma-ray spectrometer based on a Pocket PC has been developed. A 12-bit pipeline analog-to-digitalconverter (ADC associated with an implemented pulse height histogram function on field programmable gate array (FPGAoperating at 15 MHz is employed for pulse height analysis from built-in pulse amplifier. The system, which interfaces withthe Pocket PC via an enhanced RS-232 serial port under the microcontroller facilitation, is utilized for spectrum acquisition,display and analysis. The pulse height analysis capability of the system was tested and it was found that the ADC integralnonlinearity of ±0.45% was obtained with the throughput rate at 160 kcps. The overall system performance was tested usinga PIN photodiode-CsI(Tl crystal coupled scintillation detector and gamma standard radioactive sources of Cs-137 andCo-60. Low cost and the compact system size as a result of the implemented logical function are also discussed.

  12. DIFFERENTIAL MODULATION OF CATECHOLAMINES BY CHLOROTRIAZINE HERBICIDES IN PHEOCHROMOCYTOMA (PC12) CELLS IN VITRO

    Science.gov (United States)

    Differential modulation of catecholamines by chlorotriazine herbicides in pheochromocytoma (PC12) cells in vitro.Das PC, McElroy WK, Cooper RL.Curriculum in Toxicology, University of North Carolina, Chapel Hill 27599, USA.Epidemiological, wildlife, and lab...

  13. Efficient Techniques for Formal Verification of PowerPC 750 Executables Project

    Data.gov (United States)

    National Aeronautics and Space Administration — We will develop an efficient tool for formal verification of PowerPC 750 executables. The PowerPC 750 architecture is used in the radiation-hardened RAD750...

  14. Programming Languages

    Indian Academy of Sciences (India)

    Author Affiliations. V Rajaraman1 2. IBM Professor of Information Technology, Jawaharlal Nehru Centre for Advanced Scientific Research, Bangalore 560012, India; Hon.Professor, Supercomputer Education & Research Centre Indian Institute of Science, Bangalore 560012, India ...

  15. Hardware/Software Expansion of Display Terminal and CPU

    Science.gov (United States)

    Adams, B. R.

    1986-01-01

    IBM PC coupling used to expand capabilities of expensive specialpurpose system. IBM PC was interfaced to Tektronix CP1151 computer through teletype port of Tektronix 4010-1 computer display terminal. Electronic interface built to provide isolation, level shifting, and signal inversion between IBM PC RS-232 port and 4010-1 terminal teletype port. Modifications to 4010-1 terminal made to increase teletype rate from 110 to 9,600 baud. Software for both computers developed to give control of DPO system to IBM PC and provide data/program file exchange between two computers. Coupling demonstrates utilization of low-cost microcomputer hardware and software to expand capabilities of expensive special-purpose computer systems.

  16. Development of educational PC software for visually impaired children

    OpenAIRE

    Holá, Klára

    2010-01-01

    The diploma work is focused on development of educational PC software dedicated to visually impaired children. It is intended for junior school-aged children with visual abilities in category of middle and high level of low vision and also for children with disorders of binocular vision. The intention of this sotware is education of visually impaired children especially in domain of knowledge about the world of animals. It also helps children to reeducate their vision abilities.

  17. MicroPCPC: A comprehensive resource for predicting and comparing plant microRNAs

    Directory of Open Access Journals (Sweden)

    Wichadakul Duangdao

    2009-08-01

    Full Text Available Abstract Background Plant microRNA (miRNA has an important role in controlling gene regulation in various biological processes such as cell development, signal transduction, and environmental responses. While information on plant miRNAs and their targets is widely available, accessible online plant miRNA resources are limited; most of them are intended for economically important crops or plant model organisms. With abundant sequence data of numerous plants in public databases such as NCBI and PlantGDB, the identification of their miRNAs and targets would benefit researchers as a central resource for the comparative studies of plant miRNAs. Results MicroPCPC is an online plant miRNA resource resulted from large-scale Expressed Sequence Tag (EST analysis. It consists of 4,006 potential miRNA candidates in 128 families of 125 plant species and 2,995 proteins (4,953 EST sequences potentially targeted by 78 families of miRNA candidates. In addition, it is incorporated with 1,727 previously reported plant mature miRNA sequences from miRBase. The μPC enables users to compare stored mature or precursor miRNAs and user-supplied sequences among plant species. The search utility allows users to investigate the predicted miRNAs and miRNA targets in detail via various search options such as miRNA family and plant species. To enhance the database usage, the prediction utility provides interactive steps for determining a miRNA or miRNA targets from an input nucleotide sequence and links the prediction results to their homologs in the μPC. Conclusion The μPC constitutes the first online resource that enables users to comprehensively compare and predict plant miRNAs and their targets. It imparts a basis for further research on revealing miRNA conservation, function, and evolution across plant species and classification. The μPC is available at http://www.biotec.or.th/isl/micropc.

  18. Quantitative Trait Locus Analysis for Deep-Sowing Germination Ability in the Maize IBM Syn10 DH Population

    Science.gov (United States)

    Liu, Hongjun; Zhang, Lin; Wang, Jiechen; Li, Changsheng; Zeng, Xing; Xie, Shupeng; Zhang, Yongzhong; Liu, Sisi; Hu, Songlin; Wang, Jianhua; Lee, Michael; Lübberstedt, Thomas; Zhao, Guangwu

    2017-01-01

    Deep-sowing is an effective measure to ensure seeds absorbing water from deep soil layer and emerging normally in arid and semiarid regions. However, existing varieties demonstrate poor germination ability in deep soil layer and some key quantitative trait loci (QTL) or genes related to deep-sowing germination ability remain to be identified and analyzed. In this study, a high-resolution genetic map based on 280 lines of the intermated B73 × Mo17 (IBM) Syn10 doubled haploid (DH) population which comprised 6618 bin markers was used for the QTL analysis of deep-sowing germination related traits. The results showed significant differences in germination related traits under deep-sowing condition (12.5 cm) and standard-germination condition (2 cm) between two parental lines. In total, 8, 11, 13, 15, and 18 QTL for germination rate, seedling length, mesocotyl length, plumule length, and coleoptile length were detected for the two sowing conditions, respectively. These QTL explained 2.51–7.8% of the phenotypic variance with LOD scores ranging from 2.52 to 7.13. Additionally, 32 overlapping QTL formed 11 QTL clusters on all chromosomes except for chromosome 8, indicating the minor effect genes have a pleiotropic role in regulating various traits. Furthermore, we identified six candidate genes related to deep-sowing germination ability, which were co-located in the cluster regions. The results provide a basis for molecular marker assisted breeding and functional study in deep-sowing germination ability of maize. PMID:28588594

  19. The 200-pc molecular cylinder in the Galactic Centre

    Science.gov (United States)

    Sofue, Yoshiaki

    2017-09-01

    Analysing the 3D structure of the molecular gas distribution in the central 200-pc region of the Galaxy, we show that the expanding molecular ring (EMR, also known as the parallelogram) and the central molecular zone (CMZ) exhibit quite different distributions and kinematics. The EMR composes a bipolar vertical cylinder with the total length as long as ˜170 pc and shows large non-circular velocities. On the contrary, the CMZ is distributed in a nearly rigid-body rotating ring and arms tightly concentrated near the galactic plane with full thickness less than ˜30 pc. Furthermore, the mass and density ratios of the EMR to CMZ are as small as ˜0.13 and 0.04, respectively. We discuss the origins of the EMR and CMZ based on the bar and explosion models. We suggest that the EMR's large vertical extent can be explained by a cylindrical shock wave model driven by an explosive activity in the Galactic Centre.

  20. Multipoint observations of Pc1-2 waves associated with a cold plasma density enhancement

    Science.gov (United States)

    Ables, S. T.; Morley, S. K.; Sciffer, M. D.; Fraser, B. J.

    2008-12-01

    During mid-September 2003 the Geostationary Operational Environmental Satellite GOES-9 observed a number of Pc1-2 (0.1-1 Hz) emissions in the dusk sector, in association with the impact of a high-speed solar wind stream. Localized enhancements in the equatorial cold plasma density were measured by the LANL MPA instrument. For one of these observations, a Defense Meteorological Satellite Program (DMSP) spacecraft, F-13, intersected the same magnetic field-line as GOES-9. We present combined observations from GOES-9 at geostationary orbit, DMSP F-13 in the topside ionosphere, and the magnetic observatory at Chokurdakh (CHD). All three observations show evidence of Pc1-2 band wave activity across a limited region. The left-hand polarization of the waves indicates that these are electromagnetic ion-cyclotron (EMIC) waves. In the region of field-line conjunction DMSP also observed high-energy ion precipitation. Using a variety of instruments and a 2.5 dimension MHD model we present a scenario for the generation of these waves and their propagation from geosynchronous orbit, through the ionosphere, to the ground.

  1. Program Accreditation and the Graduate Reference Curriculum in Systems Engineering (GRCSE (trademark))

    Science.gov (United States)

    2012-07-01

    variables , and discrete mathematics. The curriculum for programs containing the modifier ―computer‖ in the title must include discrete mathematics...Engineer consultant to Lockheed Martin, IBM, and EDO Ceramics, for ASSETT. Dr. Squires holds INCOSE CSEP, CSEP-Acquisition certifications

  2. File list: His.Lng.20.AllAg.PC-9 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available His.Lng.20.AllAg.PC-9 hg19 Histone Lung PC-9 SRX815736,SRX815737,SRX815738,SRX12936...76,SRX815739,SRX1293674,SRX1293677,SRX1293675 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/His.Lng.20.AllAg.PC-9.bed ...

  3. File list: ALL.Lng.05.AllAg.PC-9 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.Lng.05.AllAg.PC-9 hg19 All antigens Lung PC-9 SRX1293676,SRX815738,SRX815739,SR...X815737,SRX815736,SRX1293674,SRX1293677,SRX1293675 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/ALL.Lng.05.AllAg.PC-9.bed ...

  4. Multi-satellite study of the excitation of Pc3 and Pc4-5 ULF waves and their penetration across the plasmapause during the 2003 Halloween superstorm

    Directory of Open Access Journals (Sweden)

    G. Balasis

    2015-10-01

    Full Text Available We use multi-satellite and ground-based magnetic data to investigate the concurrent characteristics of Pc3 (22–100 mHz and Pc4-5 (1–22 mHz ultra-low-frequency (ULF waves on the 31 October 2003 during the Halloween magnetic superstorm. ULF waves are seen in the Earth's magnetosphere, topside ionosphere, and Earth's surface, enabling an examination of their propagation characteristics. We employ a time–frequency analysis technique and examine data from when the Cluster and CHAMP spacecraft were in good local time (LT conjunction near the dayside noon–midnight meridian. We find clear evidence of the excitation of both Pc3 and Pc4-5 waves, but more significantly we find a clear separation in the L shell of occurrence of the Pc4-5 and Pc3 waves in the equatorial inner magnetosphere, separated by the density gradients at the plasmapause boundary layer. A key finding of the wavelet spectral analysis of data collected from the Geotail, Cluster, and CHAMP spacecraft and the CARISMA and GIMA magnetometer networks was a remarkably clear transition of the waves' frequency into dominance in a higher-frequency regime within the Pc3 range. Analysis of the local field line resonance frequency suggests that the separation of the Pc4-5 and Pc3 emissions across the plasmapause is consistent with the structure of the inhomogeneous field line resonance Alfvén continuum. The Pc4-5 waves are consistent with direct excitation by the solar wind in the plasma trough, as well as Pc3 wave absorption in the plasmasphere following excitation by upstream waves originating at the bow shock in the local noon sector. However, despite good solar wind coverage, our study was not able to unambiguously identify a clear explanation for the sharp universal time (UT onset of the discrete frequency and large-amplitude Pc3 wave power.

  5. Multi-satellite study of the excitation of Pc3 and Pc4-5 ULF waves and their penetration across the plasmapause during the 2003 Halloween superstorm

    Science.gov (United States)

    Balasis, G.; Daglis, I. A.; Mann, I. R.; Papadimitriou, C.; Zesta, E.; Georgiou, M.; Haagmans, R.; Tsinganos, K.

    2015-10-01

    We use multi-satellite and ground-based magnetic data to investigate the concurrent characteristics of Pc3 (22-100 mHz) and Pc4-5 (1-22 mHz) ultra-low-frequency (ULF) waves on the 31 October 2003 during the Halloween magnetic superstorm. ULF waves are seen in the Earth's magnetosphere, topside ionosphere, and Earth's surface, enabling an examination of their propagation characteristics. We employ a time-frequency analysis technique and examine data from when the Cluster and CHAMP spacecraft were in good local time (LT) conjunction near the dayside noon-midnight meridian. We find clear evidence of the excitation of both Pc3 and Pc4-5 waves, but more significantly we find a clear separation in the L shell of occurrence of the Pc4-5 and Pc3 waves in the equatorial inner magnetosphere, separated by the density gradients at the plasmapause boundary layer. A key finding of the wavelet spectral analysis of data collected from the Geotail, Cluster, and CHAMP spacecraft and the CARISMA and GIMA magnetometer networks was a remarkably clear transition of the waves' frequency into dominance in a higher-frequency regime within the Pc3 range. Analysis of the local field line resonance frequency suggests that the separation of the Pc4-5 and Pc3 emissions across the plasmapause is consistent with the structure of the inhomogeneous field line resonance Alfvén continuum. The Pc4-5 waves are consistent with direct excitation by the solar wind in the plasma trough, as well as Pc3 wave absorption in the plasmasphere following excitation by upstream waves originating at the bow shock in the local noon sector. However, despite good solar wind coverage, our study was not able to unambiguously identify a clear explanation for the sharp universal time (UT) onset of the discrete frequency and large-amplitude Pc3 wave power.

  6. Ellipsometric study of the optical transitions of PC{sub 60}BM and PC{sub 70}BM thin films

    Energy Technology Data Exchange (ETDEWEB)

    Bencheikh Aboura, Fatima, E-mail: fatima.bencheikh-aboura@im2np.fr; Duché, D.; Simon, J.J.; Escoubas, L.

    2015-04-01

    Highlights: • We determine the optical properties of two fullerene derivatives using ellipsometry. • Multisample analysis is applied to verify the uniqueness of the model. • The energy position of the oscillators used are compared with ones present in the parent molecules. - Abstract: Spectroscopic ellipsometry is used to determine the optical properties and to extract electronic transitions of PC{sub 60}BM and PC{sub 70}BM thin films in the UV–Visible range. By means of a sum of Gaussian oscillators, the imaginary parts of dielectric functions of both materials are modeled. The physical meaning of each model is checked by comparing the energy position of the oscillators with known optical transitions of the C{sub 60} and C{sub 70} molecules as revealed in literature by others techniques. It is shown that spectroscopic ellipsometry is a powerful technique to investigate the electronic structure of pi-conjugated molecules.

  7. Static and Dynamic Energetic Disorders in the C 60 , PC 61 BM, C 70 , and PC 71 BM Fullerenes

    KAUST Repository

    Tummala, Naga Rajesh

    2015-09-17

    We use a combination of molecular dynamics simulations and density functional theory calculations to investigate the energetic disorder in fullerene systems. We show that the energetic disorder evaluated from an ensemble average contains contributions of both static origin (time-independent, due to loose packing) and dynamic origin (time-dependent, due to electron-vibration interactions). In order to differentiate between these two contributions, we compare the results obtained from an ensemble average approach with those derived from a time average approach. It is found that in both amorphous C60 and C70 bulk systems, the degrees of static and dynamic disorder are comparable, while in the amorphous PC61BM and PC71BM systems, static disorder is about twice as large as dynamic disorder. © 2015 American Chemical Society.

  8. GEOCHEM-EZ: a chemical speciation program with greater power and flexibility

    Science.gov (United States)

    GEOCHEM –EZ is a multi-functional chemical speciation program, which was designed to replace the existing GEOCHEM-PC, a program that can only be used on DOS consoles. Chemical speciation programs, such as GEOCHEM (Sposito and Mattigod, 1980) and GEOCHEM-PC (Parker et al., 1995), have been excellent ...

  9. Activated T cells exhibit increased uptake of silicon phthalocyanine Pc 4 and increased susceptibility to Pc 4-photodynamic therapy-mediated cell death

    Science.gov (United States)

    Soler, David C.; Ohtola, Jennifer; Sugiyama, Hideaki; Rodriguez, Myriam E.; Han, Ling; Oleinick, Nancy L.; Lam, Minh; Baron, Elma D.; Cooper, Kevin D.; McCormick, Thomas S.

    2016-01-01

    Photodynamic therapy (PDT) is an emerging treatment for malignant and inflammatory dermal disorders. Photoirradiation of the silicon phthalocyanine (Pc) 4 photosensitizer with red light generates singlet oxygen and other reactive oxygen species to induce cell death. We previously reported that Pc 4-PDT elicited cell death in lymphoid-derived (Jurkat) and epithelial-derived (A431) cell lines in vitro, and furthermore that Jurkat cells were more sensitive than A431 cells to treatment. In this study, we examined the effectiveness of Pc 4-PDT on primary human CD3+ T cells in vitro. Fluorometric analyses of lysed T cells confirmed the dose-dependent uptake of Pc 4 in non-stimulated and stimulated T cells. Flow cytometric analyses measuring annexin V and propidium iodide (PI) demonstrated a dose-dependent increase of T cell apoptosis (6.6–59.9%) at Pc 4 doses ranging from 0–300 nM. Following T cell stimulation through the T cell receptor using a combination of anti-CD3 and anti-CD28 antibodies, activated T cells exhibited increased susceptibility to Pc 4-PDT-induced apoptosis (10.6–81.2%) as determined by Pc 4 fluorescence in each cell, in both non-stimulated and stimulated T cells, Pc 4 uptake increased with Pc 4 dose up to 300 nM as assessed by flow cytometry. The mean fluorescence intensity (MFI) of Pc 4 uptake measured in stimulated T cells was significantly increased over the uptake of resting T cells at each dose of Pc 4 tested (50, 100, 150 and 300nM, p<0.001 between 50 and 150nM, n=8). Treg uptake was diminished relative to other T cells. Cutaneous T cell lymphoma (CTCL) T cells appeared to take up somewhat more Pc 4 than normal resting T cells at 100 and 150nm Pc 4. Confocal imaging revealed that Pc 4 localized in cytoplasmic organelles, with approximately half of the Pc 4 co-localized with mitochondria in T cells. Thus, Pc 4-PDT exerts an enhanced apoptotic effect on activated CD3+ T cells that may be exploited in targeting T cell-mediated skin diseases

  10. Designing and Programming CICS Applications

    CERN Document Server

    Horswill, John

    2011-01-01

    CICS is an application server that delivers industrial-strength, online transaction management for critical enterprise applications. Proven in the market for over 30 years with many of the world's leading businesses, CICS enables today's customers to modernize and extend their applications to take advantage of the opportunities provided by e-business while maximizing the benefits of their existing investments. Designing and Programming CICS Applications will benefit a diverse audience. It introduces new users of IBM's mainframe (OS/390) to CICS features. It shows experienced users how t

  11. Troubleshooting and Maintaining Your PC All-in-One Desk Reference For Dummies

    CERN Document Server

    Gookin, Dan

    2009-01-01

    Maintaining a PC is important, and troubleshooting a PC can be a challenge. Dan Gookin is great at explaining how to handle common PC problems, and he's provided a complete, plain-English manual in Troubleshooting & Maintaining Your PC All-in-One For Dummies. Liberally laced with Dan's famous humor and clear instructions, Troubleshooting & Maintaining Your PC All-in-One For Dummies is divided into six minibooks covering hardware, software, laptops, Internet, networking, and maintenance. Each one gives you some background on what causes common problems, to help you understand what's wrong as we

  12. Graphics of diffraction spectra for PC; Graficado de espectros de difraccion para microcomputadora PC

    Energy Technology Data Exchange (ETDEWEB)

    Macias B, L.R

    1991-09-15

    The materials can be studied by means of diffraction if these are crystalline; of the type of study will depend the technique to apply, the first step is the obtaining of a digital register that allows to build the corresponding spectra. The digital register should have well-known the initial and final angular data. The main objective of this work, is starting of a digital register of data or an arrangement CPSi type (counts per second measured by the detection system) generated by means of the diffractometer, to create the graph of the corresponding spectra in visual form in the screen of a microcomputer and if is required, to obtain the graph in printed form by means of the same computer program for microcomputer. (Author)

  13. Pc 5 ULF waves observed simultaneously by GOES 7 and the CANOPUS magnetometer array

    Energy Technology Data Exchange (ETDEWEB)

    Ziesolleck, C.W.S.; Feng, Q.; McDiarmid, D.R. [National Research Council of Canada, Ottawa, Ontario (Canada)

    1996-03-01

    The authors have looked at a months worth of data from the CANOPUS magnetometer array (Canadian Auroral Network for the OPEN Program Unified Study) in conjunction with satellite observations from GOES 7 taken in March 1990. Applying filtering techniques they extract Pc 5 type event signatures from this data, and find several events clearly observable in both data sets. The satellite indicated dominantly compressional type events associated with field line resonances. The ground system allows the observation of polarization characteristics, in addition to being able to infer points of origin for the wave events. They then correlate the satellite observations versus relative position from the wave origin. This study shows daily variations in the signals and implies an origin for these compressional waves near local noon.

  14. A PC parallel port button box provides millisecond response time accuracy under Linux.

    Science.gov (United States)

    Stewart, Neil

    2006-02-01

    For psychologists, it is sometimes necessary to measure people's reaction times to the nearest millisecond. This article describes how to use the PC parallel port to receive signals from a button box to achieve millisecond response time accuracy. The workings of the parallel port, the corresponding port addresses, and a simple Linux program for controlling the port are described. A test of the speed and reliability of button box signal detection is reported. If the reader is moderately familiar with Linux, this article should provide sufficient instruction for him or her to build and test his or her own parallel port button box. This article also describes how the parallel port could be used to control an external apparatus.

  15. Initial growth mode, nanostructure, and molecular stacking of a ZnPc:C60 bulk heterojunction

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Hyo Jung; Kim, Ji Whan; Kim, Jang-Joo [Department of Materials Science and Engineering and OLED Center, Seoul National University, Seoul (Korea, Republic of); Lee, Hyun Hwi [Pohang Accelerator Laboratory, POSTECH, Pohang, Gyungbuk (Korea, Republic of); Lee, Byeongdu [X-ray Science Division, Argonne National Laboratory, Argonne, IL (United States)

    2012-10-23

    The initial growth modes of ZnPc films is examined, revealing the previously undescribed nanoscale crystal structure evolution and the nanograins of the ZnPc:C60 mixed layers in the thin films. Initially, the ZnPc molecules are stacked in the preferred {gamma}(200) configuration, similar to the structures of CuPc. The ZnPc thin film growth display 2D planar to 3D island growth after the initial compressive strain had relaxed in films 7-8 MLs thick. 3D island formation decreases the prevalence of the preferred ordering in the {gamma}(200) crystals. The ZnPc films consist of randomly distributed ellipsoid nanograins during the initial growth stages. The ellipsoid nanograins transition to an ordered state later in the growth process. Insertion of C60 changes the preferred molecular stacking of ZnPc, and {beta}(100) forms in the ZnPc:C60 layers fabricated at room temperature, which is usually observed at high annealing temperatures (200 C) in a single ZnPc film. The ellipsoid ZnPc nanograins also retain their shapes in the ZnPc:C60 mixed layers. The formation of {beta}(100) and the presence of ellipsoid nanograins in the mixed layer are related to improvements relative to planar devices in the organic photovoltaic device performance. (Copyright copyright 2012 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  16. Nasal associated lymphoid tissue of the Syrian golden hamster expresses high levels of PrPC.

    Directory of Open Access Journals (Sweden)

    Melissa D Clouse

    Full Text Available The key event in the pathogenesis of the transmissible spongiform encephalopathies is a template-dependent misfolding event where an infectious isoform of the prion protein (PrPSc comes into contact with native prion protein (PrPC and changes its conformation to PrPSc. In many extraneurally inoculated models of prion disease this PrPC misfolding event occurs in lymphoid tissues prior to neuroinvasion. The primary objective of this study was to compare levels of total PrPC in hamster lymphoid tissues involved in the early pathogenesis of prion disease. Lymphoid tissues were collected from golden Syrian hamsters and Western blot analysis was performed to quantify PrPC levels. PrPC immunohistochemistry (IHC of paraffin embedded tissue sections was performed to identify PrPC distribution in tissues of the lymphoreticular system. Nasal associated lymphoid tissue contained the highest amount of total PrPC followed by Peyer's patches, mesenteric and submandibular lymph nodes, and spleen. The relative levels of PrPC expression in IHC processed tissue correlated strongly with the Western blot data, with high levels of PrPC corresponding with a higher percentage of PrPC positive B cell follicles. High levels of PrPC in lymphoid tissues closely associated with the nasal cavity could contribute to the relative increased efficiency of the nasal route of entry of prions, compared to other routes of infection.

  17. Automatic Determination of the Need for Intravenous Contrast in Musculoskeletal MRI Examinations Using IBM Watson's Natural Language Processing Algorithm.

    Science.gov (United States)

    Trivedi, Hari; Mesterhazy, Joseph; Laguna, Benjamin; Vu, Thienkhai; Sohn, Jae Ho

    2017-09-18

    Magnetic resonance imaging (MRI) protocoling can be time- and resource-intensive, and protocols can often be suboptimal dependent upon the expertise or preferences of the protocoling radiologist. Providing a best-practice recommendation for an MRI protocol has the potential to improve efficiency and decrease the likelihood of a suboptimal or erroneous study. The goal of this study was to develop and validate a machine learning-based natural language classifier that can automatically assign the use of intravenous contrast for musculoskeletal MRI protocols based upon the free-text clinical indication of the study, thereby improving efficiency of the protocoling radiologist and potentially decreasing errors. We utilized a deep learning-based natural language classification system from IBM Watson, a question-answering supercomputer that gained fame after challenging the best human players on Jeopardy! in 2011. We compared this solution to a series of traditional machine learning-based natural language processing techniques that utilize a term-document frequency matrix. Each classifier was trained with 1240 MRI protocols plus their respective clinical indications and validated with a test set of 280. Ground truth of contrast assignment was obtained from the clinical record. For evaluation of inter-reader agreement, a blinded second reader radiologist analyzed all cases and determined contrast assignment based on only the free-text clinical indication. In the test set, Watson demonstrated overall accuracy of 83.2% when compared to the original protocol. This was similar to the overall accuracy of 80.2% achieved by an ensemble of eight traditional machine learning algorithms based on a term-document matrix. When compared to the second reader's contrast assignment, Watson achieved 88.6% agreement. When evaluating only the subset of cases where the original protocol and second reader were concordant (n = 251), agreement climbed further to 90.0%. The classifier was

  18. Development and application of an inhalation bioaccessibility method (IBM) for lead in the PM10 size fraction of soil.

    Science.gov (United States)

    Boisa, Ndokiari; Elom, Nwabueze; Dean, John R; Deary, Michael E; Bird, Graham; Entwistle, Jane A

    2014-09-01

    An approach for assessing the inhalation bioaccessibility of Pb in the PM10 size fraction is presented, using an in vitro simulated epithelial lung fluid to represent the extracellular environment of the lung. The developed inhalation bioaccessibility method (IBM) is applied to a range of urban surface soils and mining wastes obtained from Mitrovica, Kosovo, a site where impacts upon human health following exposure to Pb have been internationally publicised. All Pb determinations were undertaken by inductively coupled plasma mass spectrometry (ICP-MS). The pseudo-total concentration of Pb (microwave acid digestion using aqua-regia) varied between matrices: smelter (20,900-72,800mgkg(-1)), topsoil (274-13,700mgkg(-1)), and tailings (2990mgkg(-1)-25,300mgkg(-1)). The in vitro inhalation bioaccessibility was typically several orders of magnitude lower: smelter (7.0-965mgkg(-1)), topsoil (9.8-1060mgkg(-1)), and tailings (0.7mgkg(-1)-49.2mgkg(-1)). The % inhalation bioaccessibility ranged from 0.02 to 11.0%, with the higher inhalation bioaccessible Pb concentrations being observed for samples from the Bosniak Mahalla area of Mitrovica (an area proposed for the relocation of internally displaced peoples). The estimated inhalation dose (for adults) calculated from the PM10 pseudo-total Pb concentration ranged from 0.369 to 1.284μgkg(-1)BWday(-1) (smelter), 0.005-0.242μgkg(-1)BWday(-1) (topsoil), and 0.053-0.446μgkg(-1)BWday(-1) (tailings). When daily inhalation doses were calculated using the bioaccessible Pb concentration the modelled exposure doses were much lower: smelter (0.0001-0.0170μgkg(-1)BWday(-1)), topsoil (0.0002-0.0187μgkg(-1)BWday(-1)) and tailings (0.0001-0.0009μgkg(-1)BWday(-1)). Modelled for the neutral pH conditions of the interstitial lung environment, the results indicate a low potential inhalation bioaccessibility for Pb in these samples. Given the already elevated environmental Pb burden experienced by the local population, where significant

  19. Analysis and IbM simulation of the stages in bacterial lag phase: basis for an updated definition.

    Science.gov (United States)

    Prats, Clara; Giró, Antoni; Ferrer, Jordi; López, Daniel; Vives-Rego, Josep

    2008-05-07

    The lag phase is the initial phase of a culture that precedes exponential growth and occurs when the conditions of the culture medium differ from the pre-inoculation conditions. It is usually defined by means of cell density because the number of individuals remains approximately constant or slowly increases, and it is quantified with the lag parameter lambda. The lag phase has been studied through mathematical modelling and by means of specific experiments. In recent years, Individual-based Modelling (IbM) has provided helpful insights into lag phase studies. In this paper, the definition of lag phase is thoroughly examined. Evolution of the total biomass and the total number of bacteria during lag phase is tackled separately. The lag phase lasts until the culture reaches a maximum growth rate both in biomass and cell density. Once in the exponential phase, both rates are constant over time and equal to each other. Both evolutions are split into an initial phase and a transition phase, according to their growth rates. A population-level mathematical model is presented to describe the transitional phase in cell density. INDividual DIScrete SIMulation (INDISIM) is used to check the outcomes of this analysis. Simulations allow the separate study of the evolution of cell density and total biomass in a batch culture, they provide a depiction of different observed cases in lag evolution at the individual-cell level, and are used to test the population-level model. The results show that the geometrical lag parameter lambda is not appropriate as a universal definition for the lag phase. Moreover, the lag phase cannot be characterized by a single parameter. For the studied cases, the lag phases of both the total biomass and the population are required to fully characterize the evolution of bacterial cultures. The results presented prove once more that the lag phase is a complex process that requires a more complete definition. This will be possible only after the phenomena

  20. RNA-binding protein regulates plant DNA methylation by controlling mRNA processing at the intronic heterochromatin-containing gene IBM1.

    Science.gov (United States)

    Wang, Xingang; Duan, Cheng-Guo; Tang, Kai; Wang, Bangshing; Zhang, Huiming; Lei, Mingguang; Lu, Kun; Mangrauthia, Satendra K; Wang, Pengcheng; Zhu, Guohui; Zhao, Yang; Zhu, Jian-Kang

    2013-09-17

    DNA methylation-dependent heterochromatin formation is a conserved mechanism of epigenetic silencing of transposons and other repeat elements in many higher eukaryotes. Genes adjacent to repetitive elements are often also subjected to this epigenetic silencing. Consequently, plants have evolved antisilencing mechanisms such as active DNA demethylation mediated by the REPRESSOR OF SILENCING 1 (ROS1) family of 5-methylcytosine DNA glycosylases to protect these genes from silencing. Some transposons and other repeat elements have found residence in the introns of genes. It is unclear how these intronic repeat elements-containing genes are regulated. We report here the identification of ANTI-SILENCING 1 (ASI1), a bromo-adjacent homology domain and RNA recognition motif-containing protein, from a forward genetic screen for cellular antisilencing factors in Arabidopsis thaliana. ASI1 is required to prevent promoter DNA hypermethylation and transcriptional silencing of some transgenes. Genome-wide DNA methylation analysis reveals that ASI1 has a similar role to that of the histone H3K9 demethylase INCREASE IN BONSAI METHYLATION 1 (IBM1) in preventing CHG methylation in the bodies of thousands of genes. We found that ASI1 is an RNA-binding protein and ensures the proper expression of IBM1 full-length transcript by associating with an intronic heterochromatic repeat element of IBM1. Through mRNA sequencing, we identified many genes containing intronic transposon elements that require ASI1 for proper expression. Our results suggest that ASI1 associates with intronic heterochromatin and binds the gene transcripts to promote their 3' distal polyadenylation. The study thus reveals a unique mechanism by which higher eukaryotes deal with the collateral effect of silencing intronic repeat elements.

  1. Functional Analysis of Mouse G6pc1 Mutations Using a Novel In Situ Assay for Glucose-6-Phosphatase Activity and the Effect of Mutations in Conserved Human G6PC1/G6PC2 Amino Acids on G6PC2 Protein Expression.

    Directory of Open Access Journals (Sweden)

    Kayla A Boortz

    Full Text Available Elevated fasting blood glucose (FBG has been associated with increased risk for development of type 2 diabetes. Single nucleotide polymorphisms (SNPs in G6PC2 are the most important common determinants of variations in FBG in humans. Studies using G6pc2 knockout mice suggest that G6pc2 regulates the glucose sensitivity of insulin secretion. G6PC2 and the related G6PC1 and G6PC3 genes encode glucose-6-phosphatase catalytic subunits. This study describes a functional analysis of 22 non-synonymous G6PC2 SNPs, that alter amino acids that are conserved in human G6PC1, mouse G6pc1 and mouse G6pc2, with the goal of identifying variants that potentially affect G6PC2 activity/expression. Published data suggest strong conservation of catalytically important amino acids between all four proteins and the related G6PC3 isoform. Because human G6PC2 has very low glucose-6-phosphatase activity we used an indirect approach, examining the effect of these SNPs on mouse G6pc1 activity. Using a novel in situ functional assay for glucose-6-phosphatase activity we demonstrate that the amino acid changes associated with the human G6PC2 rs144254880 (Arg79Gln, rs149663725 (Gly114Arg and rs2232326 (Ser324Pro SNPs reduce mouse G6pc1 enzyme activity without affecting protein expression. The Arg79Gln variant alters an amino acid mutation of which, in G6PC1, has previously been shown to cause glycogen storage disease type 1a. We also demonstrate that the rs368382511 (Gly8Glu, rs138726309 (His177Tyr, rs2232323 (Tyr207Ser rs374055555 (Arg293Trp, rs2232326 (Ser324Pro, rs137857125 (Pro313Leu and rs2232327 (Pro340Leu SNPs confer decreased G6PC2 protein expression. In summary, these studies identify multiple G6PC2 variants that have the potential to be associated with altered FBG in humans.

  2. Inhibition of various steps in the replication cycle of vesicular stomatitis virus contributes to its photoinactivation by AlPcS4 or Pc4 and red light

    NARCIS (Netherlands)

    Moor, ACE; Wagenaars-van Gompel, AE; Hermanns, RCA; van der Meulen, J; Smit, J; Wilschut, J; Brand, A; Dubbelman, TMAR; VanSteveninck, J

    Vesicular stomatitis virus (VSV) was used as a model virus to study the processes involved in photoinactivation by aluminum phthalocyanine tetrasulfonate (AIPcS(4),) or silicon phthalocyanine HOSiPcOSi(CH3)(2)(CH2)(3)N(CH3)(2) (Pc4) and red light. Previously a very rapid decrease in the

  3. Downregulation of DNA (cytosine-5-)methyltransferase is a late event in NGF-induced PC12 cell differentiation.

    Science.gov (United States)

    Deng, J; Szyf, M

    1999-07-23

    DNA methylation patterns are a critical component of the epigenetic machinery that controls the expression of genetic programs in vertebrates. DNA methyltransferase gene (dnmt1) encodes the enzyme catalyzing the methylation of DNA during replication. We tested the hypothesis that the expression of dnmt1 is regulated with the developmental state of neuronal cells. We show that DNA methyltransferase (Dnmt1) activity is sharply reduced 4 days after induction of differentiation of PC12 cells with NGF. Similarly, the adult brain expresses reduced levels of Dnmt1 activity. We propose that the level of Dnmt1 is downregulated to adjust the activity of the DNA methyltransferase to a different role in mature post-mitotic neurons. Both the abundance of dnmt1 mRNA as well as the Dnmt1 polypeptide are downregulated. Downregulation of dnmt1 parallels other indicators of withdrawal from the cell cycle such as induction of p21, and downregulation of the S phase maker PCNA (proliferating cell nuclear antigen). The temporal pattern of downregulation of dnmt1 in nerve growth factor (NGF)-induced PC12 cells is different from myotube differentiation where downregulation of DNA methyltransferase and demethylation is an early event and was proposed to play a causal role in differentiation. We propose that NGF differentiation of PC12 cells represents a different paradigm of involvement of DNA methylation in terminal differentiation. Copyright 1999 Elsevier Science B.V.

  4. Should individuals with chronic aphasia be treated with dedicated PC-based training? Considerations about a case study.

    Science.gov (United States)

    De Luca, Rosaria; Calabrò, Rocco Salvatore; Reitano, Simone; Digangi, Giuseppina; Bertè, Francesco; Sergi, Giuseppa; Bramanti, Placido

    2014-01-01

    Aim of this study was to evaluate the effects of an emerging rehabilitative tool ("Power-AFA" - software) in the recovery of a patient with chronic non-fluent aphasia. A 56-year-old woman, affected by post-stroke severe expressive aphasia, underwent two different intensive rehabilitation trainings, including either standard language rehabilitation alone or a proper PC based speech training in addition to conventional treatment. We evaluated her cognitive and psychological profile in two separate sessions, before and after the two different trainings, by using a proper psychometric battery, to assess cognitive status, language abilities, and to estimate the presence of mood alterations and coping strategies. The overall PC-program was articulated in 6 sessions/weekly for 3 months. Only at the end of the PC-training, we observed an important improvement in peculiar cognitive domains (attention and memory functions), in denomination, in verbal understanding ability, in written, in communication skills as well as an optimization of the mood and coping styles. Computer-based cognitive and language rehabilitation, using proper and dedicated software, may be a valuable tool in improving either communication or cognitive skills in patient affected by aphasia, even in the chronic state.

  5. Characterization of RNA interference in rat PC12 cells

    DEFF Research Database (Denmark)

    Thonberg, Håkan; Schéele, Camilla C; Dahlgren, Cecilia

    2004-01-01

    Double-stranded RNA can initiate post transcriptional gene silencing in mammalian cell cultures via a mechanism known as RNA interference (RNAi). The sequence-specific degradation of homologous mRNA is triggered by 21-nucleotide RNA-duplexes termed short interfering RNA (siRNA). The homologous...... strand of the siRNA guides a multi-protein complex, RNA-induced silencing complex (RISC), to cleave target mRNA. Although the exact function and composition of RISC is still unclear, it has been shown to include several proteins of the Argonaute protein family. Here we report of a robust system...... to achieve RNAi in a cultured rat neuronal cell line, PC12. Targeting of neuropeptide Y mRNA by synthetic siRNA results in knock down of the mRNA levels with an IC50 of approximately 0.1 nM. The mRNA knockdown lasts for at least 96 h and is not dependent on protein synthesis. Further, PC12 cells were ablated...

  6. Found a USB stick? Go and infect your PC!

    CERN Multimedia

    Computer Security Team

    2012-01-01

    Err. Wait. Please no! USB sticks are not innocent little things. They can quickly mutate into malicious nasty beasts! Just in the recent past, at least two physics experiments were suffering as their control and data acquisition PCs, respectively, were infected by USB sticks holding malicious code. A bit longer ago, a series of laptops were infected at a 2008 computing conference as an infected USB stick made its tour around. Bad luck for those who ran a Windows operating system and inserted that stick…   So, you found a USB stick in the cafeteria? Take care. If this were a lollipop, you wouldn’t just pick it up and lick it, would you? So beware of USB sticks whose origin or previous usage you don’t know. They might infect your PC once plugged in. In order to be on the safe side, accept and share only USB sticks whose owner you trust. Run up-to-date anti-virus software on your PC, make sure that its operating system is patched...

  7. From a UNIX to a PC Based SCADA System

    CERN Document Server

    Momal, F

    1999-01-01

    In order to facilitate the development of supervisory applications involved in slow process control (such as cryogenic control), the LHC/IAS Group (Equipment Controls Group) opted, a few years ago, for an industrial SCADA package which runs on UNIXÒ platforms. However, to reduce costs and following market trends, it has been decided to move over to a PC-based package. Several processes relating to the testing of the prototypes of the LHC magnets are already controlled in this way. However, it was still necessary to provide all the services previously available to the users, for example, data archiving in central databases, real-time access through the Web, automatic GSM calls, etc. This paper presents the advantages and drawbacks of a PC-based package versus a Unix-based system. It also lists the criteria used in the market survey to arrive at the final selection, as well as, the overall architecture, highlighting the developments needed to integrate the package into the global computing environment.

  8. Suppression of PC-1/ENPP-1 expression improves insulin sensitivity in vitro and in vivo.

    Science.gov (United States)

    Zhou, Heather H; Chin, Chen-Ni; Wu, Margaret; Ni, Weihua; Quan, Shuo; Liu, Franklin; Dallas-Yang, Qing; Ellsworth, Kenneth; Ho, Thu; Zhang, Aiwu; Natasha, Tajneen; Li, Jing; Chapman, Kevin; Strohl, William; Li, Cai; Wang, I-Ming; Berger, Joel; An, Zhiqiang; Zhang, Bei B; Jiang, Guoqiang

    2009-08-15

    Plasma cell membrane glycoprotein-1, or ectonucleotide pyrophosphatase/phosphodieterase (PC-1/ENPP1) has been shown to inhibit insulin signaling in cultured cells in vitro and in transgenic mice in vivo when overexpressed. Furthermore, both genetic polymorphism and increased expression of PC-1 have been reported to be associated with type 2 diabetes in humans. Thus it was proposed that PC-1 inhibition represents a potential strategy for the treatment of type 2 diabetes. However, it has not been proven that suppression of PC-1 expression or inhibition of its function will actually improve insulin sensitivity. We show in the current study that transient overexpression of PC-1 inhibits insulin-stimulated insulin receptor tyrosine phosphorylation in HEK293 cells, while knockdown of PC-1 with siRNA significantly increases insulin-stimulated Akt phosphorylation in HuH7 human hepatoma cells. Adenoviral vector expressing a short hairpin RNA against mouse PC-1 (PC-1shRNA) was utilized to efficiently knockdown PC-1 expression in the livers of db/db mice. In comparison with db/db mice treated with a control virus, db/db mice treated with the PC-1shRNA adenovirus had approximately 80% lower hepatic PC-1 mRNA levels, approximately 30% lower ambient fed plasma glucose, approximately 25% lower fasting plasma glucose, and significantly improved oral glucose tolerance. Taken together, these results demonstrate that suppression of PC-1 expression improves insulin sensitivity in vitro and in an animal model of diabetes, supporting the proposition that PC-1 inhibition is a potential therapeutic approach for the treatment of type 2 diabetes.

  9. The National Shipbuilding Research Program, 1990 Ship Production Symposium, Paper No. 4A-1: Cost Effective Planning and Control

    Science.gov (United States)

    1990-08-01

    INNOVATION MARINE INDUSTRY STANDARDS WELDING INDUSTRIAL ENGINEERING EDUCATION AND TRAINING THE NATIONAL SHIPBUILDING RESEARCH PROGRAM August 1990 NSRP 0320...software was developed using a proprietary database product for an IBM compatible personal computer. It is menu driven, and uses customised input

  10. RENEW - MAINTENANCE ESTIMATION SIMULATION MODEL FOR SPACE STATION FREEDOM PROGRAM, VERSION 3.2

    Science.gov (United States)

    Bream, B. L.

    1994-01-01

    RENEW is a maintenance event estimation simulation program developed in support of the Space Station Freedom Program (SSFP) Work Package 4 at NASA Lewis Research Center. This simulation uses reliability and maintainability (R&M) data as well as logistics data to estimate both average and time dependent maintenance demands. RENEW uses Monte Carlo techniques to generate failure and repair times as a function of the R&M and logistics parameters. The estimates are generated for a single type of orbital replacement unit (ORU). The RENEW simulation gives closer estimates of performance than steady-state average calculations since it uses a time dependent approach and depicts more factors affecting ORU failure and repair. RENEW gives both average and time dependent demand values, and generates graphs of both failures over the mission period and yearly failure occurrences. The average demand rate for the ORU over the mission period is also calculated. While RENEW displays the results in graphs, the results are also available in data tables. The process of using RENEW starts with keyboard entry of the R&M and operational data. Once entered, the data may be saved in a data file for later retrieval, and the parameters may be viewed and changed. The simulation program runs the number of Monte Carlo simulations requested by the operator. Plots and tables of the results can be viewed on the screen or sent to a printer. The results of the simulation are saved along with the input data. Help screens are provided with each menu and data entry screen. RENEW is written in BASIC and assembly language for IBM PC series and compatible computers running MS-DOS. Microsoft's QuickBasic Professional Development System and Crescent Software's QuickPak Professional are required to compile the source code. A CGA or VGA monitor is required. A sample executable is provided on the distribution media. The standard distribution medium for this program is one 5.25 inch 360K MS-DOS format diskette

  11. Deep Unsupervised Learning on a Desktop PC: A Primer for Cognitive Scientists

    Science.gov (United States)

    Testolin, Alberto; Stoianov, Ivilin; De Filippo De Grazia, Michele; Zorzi, Marco

    2013-01-01

    Deep belief networks hold great promise for the simulation of human cognition because they show how structured and abstract representations may emerge from probabilistic unsupervised learning. These networks build a hierarchy of progressively more complex distributed representations of the sensory data by fitting a hierarchical generative model. However, learning in deep networks typically requires big datasets and it can involve millions of connection weights, which implies that simulations on standard computers are unfeasible. Developing realistic, medium-to-large-scale learning models of cognition would therefore seem to require expertise in programing parallel-computing hardware, and this might explain why the use of this promising approach is still largely confined to the machine learning community. Here we show how simulations of deep unsupervised learning can be easily performed on a desktop PC by exploiting the processors of low cost graphic cards (graphic processor units) without any specific programing effort, thanks to the use of high-level programming routines (available in MATLAB or Python). We also show that even an entry-level graphic card can outperform a small high-performance computing cluster in terms of learning time and with no loss of learning quality. We therefore conclude that graphic card implementations pave the way for a widespread use of deep learning among cognitive scientists for modeling cognition and behavior. PMID:23653617

  12. Deep unsupervised learning on a desktop PC: A primer for cognitive scientists

    Directory of Open Access Journals (Sweden)

    Alberto eTestolin

    2013-05-01

    Full Text Available Deep belief networks hold great promise for the simulation of human cognition because they show how structured and abstract representations may emerge from probabilistic unsupervised learning. These networks build a hierarchy of progressively more complex distributed representations of the sensory data by fitting a hierarchical generative model. However, learning in deep networks typically requires big datasets and it can involve millions of connection weights, which implies that simulations on standard computers are unfeasible. Developing realistic, medium-to-large-scale learning models of cognition would therefore seem to require expertise in programming parallel-computing hardware, and this might explain why the use of this promising approach is still largely confined to the machine learning community. Here we show how simulations of deep unsupervised learning can be easily performed on a desktop PC by exploiting the processors of low-cost graphic cards (GPUs without any specific programming effort, thanks to the use of high-level programming routines (available in MATLAB or Python. We also show that even an entry-level graphic card can outperform a small high-performance computing cluster in terms of learning time and with no loss of learning quality. We therefore conclude that graphic card implementations pave the way for a widespread use of deep learning among cognitive scientists for modeling cognition and behavior.

  13. Cross software for microprocessor program development at CERN

    CERN Document Server

    Von Eicken, H; Montuelle, J; Willers, I

    1981-01-01

    Programs for a variety of microprocessors (including Intel 8080; Motorola 6800, 6809 and 68000; and Texas Instruments 9900) can be prepared on different host computers (such as IBM 370, CDC 6000, and Nord 10) using portable programs developed at CERN. The range of cross software consists of: an assembler for each target microprocessor, a single linkage editor, a single object module librarian, and a variety of pre-loaders which convert object modules from CERN's format (CUFOM) into manufacturers' formats. The programs are written in BCPL and PASCAL, programming languages which are available on a wide range of computers.

  14. Validation of MCNP4a for highly enriched uranium using the Battelle process safety and risk management IBM RS/6000 workstation

    Energy Technology Data Exchange (ETDEWEB)

    Negron, S.B.; Lee, B.L. Jr.; Tayloe, R.W. Jr.

    1996-01-01

    This document has been prepared to allow use of the Radiation Shielding and Information Center (RSIC) release of MCNP4a, which has been installed on the Battelle Process Safety and Risk Management (PSRM) IBM RS/6000 workstation, for production calculations for the Portsmouth Gaseous Diffusion Plant (PORTS). This hardware/software configuration is under the configuration control plan listed in Reference 1. The first portion of this document outlines basic information with regard to validation of MCNP4a using the supplied cross sections and the additional MCNPDAT cross sections. A basic discussion of MCNP is provided, along with discussions of the validation database in general. A description of the statistical analysis then follows. The results of this validation indicate that the software and data libraries examined may be used with confidence for criticality calculations at the Portsmouth Gaseous Diffusion Plant (PORTS). When the validation results are treated as a single group, there is a 95% confidence that 99.9% of future calculations of similar critical systems will have a calculated k{sub eff} > 0.95. Based on this result, the Battelle PSRM Nuclear Safety Group has adopted the calculational acceptance criteria that a calculated k{sub eff} + 2{sigma}, {le} 0.95 is safely subcritical. The conclusion of this document is that MCNP4a and all associated cross section libraries installed on the PSRM IBM RS/6000 are acceptable for use in performing production criticality safety calculations for the Portsmouth Gaseous Diffusion Plant.

  15. [Method for concentrating marrow stem cells using the IBM 2991 washer. Necessary preparation before in vitro treatment of bone marrow by pharmacologic or immunologic means].

    Science.gov (United States)

    Hervé, P; Coffe, C; Peters, A

    1983-04-01

    The technique using the IBM 2991 blood cell processor is an effective technique for the concentration of mononuclear cells from large volumes of bone marrow. The marrow cells are layered on to Ficoll Metrizoate using the IBM processing set. The mononuclear cells and CFU-GM recoveries are in close relationship with the hematocrit of the cell suspension processed. Twenty two bone marrows have been collected and purified according to this protocol. The mononuclear cell recovery is an average of 78,3% (range: 44-92%) and the CFU-GM recovery is in average of 67,5% (range: 40-89%). At the end of the procedure the cell viability is satisfying (97,1% +/- 1,7 are trypan blue negatives). When it is necessary to remove from the bone marrow collected either malignant cells prior autologous bone marrow graft or T lymphocytes in an attempt to prevent GVHD in allogeneic BMT, the purity of marrow cell suspension become a fundamental parameter.

  16. Platycodin D induced apoptosis and autophagy in PC-12 cells through mitochondrial dysfunction pathway

    Science.gov (United States)

    Zeng, Chuan-Chuan; Zhang, Cheng; Yao, Jun-Hua; Lai, Shang-Hai; Han, Bing-Jie; Li, Wei; Tang, Bing; Wan, Dan; Liu, Yun-Jun

    2016-11-01

    In this article, the in vitro cytotoxicity of platycodin D was evaluated in human PC-12, SGC-7901, BEL-7402, HeLa and A549 cancer cell lines. PC-12 cells were sensitive to platycodin D treatment, with an IC50 value of 13.5 ± 1.2 μM. Morphological and comet assays showed that platycodin D effectively induced apoptosis in PC-12 cells. Platycodin D increased the levels of reactive oxygen species (ROS) and induced a decrease in mitochondrial membrane potential. Platycodin D induced cell cycle arrest at the G0/G1 phase in the PC-12 cell line. Platycodin D can induce autophagy. In addition, platycodin D can down-regulate the expression of Bcl-2 and Bcl-x, and up-regulate the levels of Bid protein in the PC-12 cells. The results demonstrated that platycodin D induced PC-12 cell apoptosis through a ROS-mediated mitochondrial dysfunction pathway.

  17. Is there a link between proprotein convertase PC7 activity and human lipid homeostasis?

    Directory of Open Access Journals (Sweden)

    Johann Guillemot

    2014-01-01

    Full Text Available A genome-wide association study suggested that a R504H mutation in the proprotein convertase PC7 is associated with increased circulating levels of HDL and reduced triglycerides in black Africans. Our present results show that PC7 and PC7-R504H exhibit similar processing of transferrin receptor-1, proSortilin, and apolipoprotein-F. Plasma analyses revealed no change in the lipid profiles, insulin or glucose of wild type and PC7 KO mice. Thus, the R504H mutation does not modify the proteolytic activity of PC7. The mechanisms behind the implication of PC7 in the regulation of human HDL, triglycerides and in modifying the levels of atherogenic small dense LDL remain to be elucidated.

  18. ParallelPC: an R package for efficient constraint based causal exploration

    OpenAIRE

    Le, Thuc Duy; Hoang, Tao; Li, Jiuyong; Liu, Lin; Hu, Shu

    2015-01-01

    Discovering causal relationships from data is the ultimate goal of many research areas. Constraint based causal exploration algorithms, such as PC, FCI, RFCI, PC-simple, IDA and Joint-IDA have achieved significant progress and have many applications. A common problem with these methods is the high computational complexity, which hinders their applications in real world high dimensional datasets, e.g gene expression datasets. In this paper, we present an R package, ParallelPC, that includes th...

  19. Live-cell monochromatic dual-label sub-diffraction microscopy by mt-pcSOFI.

    Science.gov (United States)

    Duwé, S; Vandenberg, W; Dedecker, P

    2017-06-29

    We expand photochromic super-resolution optical fluctuation imaging (pcSOFI) to monochromatic dual-channel sub-diffraction microscopy. Multi-tau (mt-)pcSOFI unmixes spectrally identical reversibly switchable fluorescent proteins (RSFPs) based on their blinking kinetics. We show that mt-pcSOFI can be used to simultaneously image two structures in living cells with existing RSFPs and the newly developed ffDronpa-F.

  20. State of the art of parallel scientific visualization applications on PC clusters; Etat de l'art des applications de visualisation scientifique paralleles sur grappes de PC

    Energy Technology Data Exchange (ETDEWEB)

    Juliachs, M

    2004-07-01

    In this state of the art on parallel scientific visualization applications on PC clusters, we deal with both surface and volume rendering approaches. We first analyze available PC cluster configurations and existing parallel rendering software components for parallel graphics rendering. CEA/DIF has been studying cluster visualization since 2001. This report is part of a study to set up a new visualization research platform. This platform consisting of an eight-node PC cluster under Linux and a tiled display was installed in collaboration with Versailles-Saint-Quentin University in August 2003. (author)

  1. Personal Computer (PC) based image processing applied to fluid mechanics

    Science.gov (United States)

    Cho, Y.-C.; Mclachlan, B. G.

    1987-01-01

    A PC based image processing system was employed to determine the instantaneous velocity field of a two-dimensional unsteady flow. The flow was visualized using a suspension of seeding particles in water, and a laser sheet for illumination. With a finite time exposure, the particle motion was captured on a photograph as a pattern of streaks. The streak pattern was digitized and processed using various imaging operations, including contrast manipulation, noise cleaning, filtering, statistical differencing, and thresholding. Information concerning the velocity was extracted from the enhanced image by measuring the length and orientation of the individual streaks. The fluid velocities deduced from the randomly distributed particle streaks were interpolated to obtain velocities at uniform grid points. For the interpolation a simple convolution technique with an adaptive Gaussian window was used. The results are compared with a numerical prediction by a Navier-Stokes computation.

  2. Pc5 waves generated by substorm injection: a case study

    Directory of Open Access Journals (Sweden)

    N. A. Zolotukhina

    2008-07-01

    Full Text Available We analyzed the spectral-polarized characteristics of Pc5 ULF waves observed on 17 September 2000 after the 03:20:25 UT substorm onset with the satellites GOES 8 and 10 located east and west of the onset location. In the course of the event, the wave polarization changed from mixed (between toroidal and poloidal to poloidal, and then to mixed again. The hodogram of magnetic field oscillations rotated counterclockwise at GOES 8, and clockwise at GOES 10. It is suggested that the satellites detected the waves generated by the substorm injected clouds of the charged particles drifting in the magnetosphere in the opposite azimuthal directions: GOES 8 (located east of the substorm onset detected the wave generated by an electron cloud, and GOES 10 (west of the onset detected the wave generated by a positive ion cloud. This interpretation is confirmed by the energetic particles data recorded by LANL satellites.

  3. Realizace miniaturních PC monitorů

    OpenAIRE

    Nečesaný, Jaroslav

    2012-01-01

    Úlohou Diplomovej práce bolo navrhnúť dve riešenia miniatúrneho PC monitoru. Jeden monitor využíva ako zdroj vstupných dát signál VGA, druhý je pripojený pomocou USB. K praktickej realizácií bol vybraný USB monitor. Zariadenie obsahuje okrem zobrazovacej jednotky LCD čítačku SD kariet a audio prevodník s reproduktorom. Programové vybavenie umožňuje sledovanie obsahu pracovnej plochy osobného počítača v nastaviteľnej polohe a veľkosti. Monitor je možné obsluhovať pomocou touchscreen. Súčasťou ...

  4. METHANE de-NOX FOR UTILITY PC BOILERS

    Energy Technology Data Exchange (ETDEWEB)

    Joseph Rabovitser

    2000-07-05

    The overall project objective is the development and validation of an innovative combustion system, based on a novel coal preheating concept prior to combustion, that can reduce NO{sub x} emissions to 0.15 lb/million Btu or less on utility pulverized coal (PC) boilers. This NO{sub x} reduction should be achieved without loss of boiler efficiency or operating stability, and at more than 25% lower levelized cost than state-of-the-art SCR technology. A further objective is to make this technology ready for full-scale commercial deployment by 2002-2003 in order to meet an anticipated market demand for NO{sub x} reduction technologies resulting from the EPA's NO{sub x} SIP call.

  5. Nuclear Factor-κB-inducing Kinase (NIK) Contains an Amino-terminal Inhibitor of Apoptosis (IAP)-binding Motif (IBM) That Potentiates NIK Degradation by Cellular IAP1 (c-IAP1)*

    Science.gov (United States)

    Lee, Sunhee; Challa-Malladi, Madhavi; Bratton, Shawn B.; Wright, Casey W.

    2014-01-01

    Activation of the noncanonical NF-κB pathway hinges on the stability of the NF-κB-inducing kinase (NIK), which is kept at low levels basally by a protein complex consisting of the E3 ubiquitin ligases cellular inhibitor of apoptosis 1 and 2 (c-IAP1/2) proteins and the tumor necrosis factor receptor-associated factors 2 and 3 (TRAF2/3). NIK is brought into close proximity to the c-IAPs through a TRAF2-TRAF3 bridge where TRAF2 recruits c-IAP1/2 and TRAF3 binds to NIK. However, it is not clear how the c-IAPs specifically recognize and ubiquitylate NIK in the complex. We have identified an IAP-binding motif (IBM) at the amino terminus of NIK. IBMs are utilized by a number of proapoptotic proteins to antagonize IAP function. Here, we utilize mutational studies to demonstrate that wild-type NIK is destabilized in the presence of c-IAP1, whereas the NIK IBM mutant is stable. NIK interacts with the second baculovirus IAP repeat (BIR2) domain of c-IAP1 via the IBM, and this interaction, in turn, provides substrate recognition for c-IAP1 mediated ubiquitylation and degradation of NIK. Furthermore, in the presence of the NIK IBM mutant, we observed an elevated processing of p100 to p52 followed by increased expression of NF-κB target genes. Together, these findings reveal the novel identification and function of the NIK IBM, which promotes c-IAP1-dependent ubiquitylation of NIK, resulting in optimal NIK turnover to ensure that noncanonical NF-κB signaling is off in the absence of an activating signal. PMID:25246529

  6. Nuclear factor-κB-inducing kinase (NIK) contains an amino-terminal inhibitor of apoptosis (IAP)-binding motif (IBM) that potentiates NIK degradation by cellular IAP1 (c-IAP1).

    Science.gov (United States)

    Lee, Sunhee; Challa-Malladi, Madhavi; Bratton, Shawn B; Wright, Casey W

    2014-10-31

    Activation of the noncanonical NF-κB pathway hinges on the stability of the NF-κB-inducing kinase (NIK), which is kept at low levels basally by a protein complex consisting of the E3 ubiquitin ligases cellular inhibitor of apoptosis 1 and 2 (c-IAP1/2) proteins and the tumor necrosis factor receptor-associated factors 2 and 3 (TRAF2/3). NIK is brought into close proximity to the c-IAPs through a TRAF2-TRAF3 bridge where TRAF2 recruits c-IAP1/2 and TRAF3 binds to NIK. However, it is not clear how the c-IAPs specifically recognize and ubiquitylate NIK in the complex. We have identified an IAP-binding motif (IBM) at the amino terminus of NIK. IBMs are utilized by a number of proapoptotic proteins to antagonize IAP function. Here, we utilize mutational studies to demonstrate that wild-type NIK is destabilized in the presence of c-IAP1, whereas the NIK IBM mutant is stable. NIK interacts with the second baculovirus IAP repeat (BIR2) domain of c-IAP1 via the IBM, and this interaction, in turn, provides substrate recognition for c-IAP1 mediated ubiquitylation and degradation of NIK. Furthermore, in the presence of the NIK IBM mutant, we observed an elevated processing of p100 to p52 followed by increased expression of NF-κB target genes. Together, these findings reveal the novel identification and function of the NIK IBM, which promotes c-IAP1-dependent ubiquitylation of NIK, resulting in optimal NIK turnover to ensure that noncanonical NF-κB signaling is off in the absence of an activating signal. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

  7. [Grape seed extract induces morphological changes of prostate cancer PC-3 cells].

    Science.gov (United States)

    Shang, Xue-Jun; Yin, Hong-Lin; Ge, Jing-Ping; Sun, Yi; Teng, Wen-Hui; Huang, Yu-Feng

    2008-12-01

    To observe the morphological changes of prostate cancer PC-3 cells induced by grape seed extract (GSE). PC-3 cells were incubated with different concentrations of GSE (100, 200 and 300 microg/ml) for 24, 48 and 72 hours, and then observed for morphological changes by invert microscopy, HE staining and transmission electron microscopy. The incubated PC-3 cells appeared round, small, wrinkled and broken under the invert microscope and exhibited the classical morphological characteristics of cell death under the electron microscope, including cell atrophy, increased vacuoles, crumpled nuclear membrane, and chromosome aggregation. GSE can cause morphological changes and induce necrosis and apoptosis of PC-3 cells.

  8. Organization and use of a Software/Hardware Avionics Research Program (SHARP)

    Science.gov (United States)

    Karmarkar, J. S.; Kareemi, M. N.

    1975-01-01

    The organization and use is described of the software/hardware avionics research program (SHARP) developed to duplicate the automatic portion of the STOLAND simulator system, on a general-purpose computer system (i.e., IBM 360). The program's uses are: (1) to conduct comparative evaluation studies of current and proposed airborne and ground system concepts via single run or Monte Carlo simulation techniques, and (2) to provide a software tool for efficient algorithm evaluation and development for the STOLAND avionics computer.

  9. Furin and proprotein convertase 7 (PC7)/lymphoma PC endogenously expressed in rat liver can be resolved into distinct post-Golgi compartments.

    Science.gov (United States)

    Wouters, S; Leruth, M; Decroly, E; Vandenbranden, M; Creemers, J W; van de Loo, J W; Ruysschaert, J M; Courtoy, P J

    1998-01-01

    The intracellular compartmentalization in rat liver of the membrane-associated convertases furin and proprotein convertase 7 (PC7)/lymphoma PC (LPC) was investigated by analytical subcellular fractionation. In control animals, both enzymes were found to localize in fractions depleted of endoplasmic reticulum, cis-Golgi and lysosomal markers, but to co-distribute with the Golgi marker galactosyltransferase and the trans-Golgi network (TGN) marker TGN38. After overloading Golgi-derived vesicles with very-low-density lipoproteins (VLDL) by feeding rats with ethanol, the distribution of PC7/LPC was shifted markedly towards lower densities, in contrast with those of furin and the TGN marker. This provides support for the TGN localization of endogenously expressed furin and indicates that, at steady state, a considerable proportion of PC7/LPC may be associated with vesicles derived from the TGN. PMID:9820806

  10. From Electrons Paired to Electric Power Delivered- A Personal Journey in Research and Applications of Superconductivity at IBM, EPRI, and Beyond

    Science.gov (United States)

    Grant, Paul

    2014-03-01

    This talk will reprise a personal journey by the speaker in industrial and applied physics, commencing with his employment by IBM at age 17 in the early 1950s, and continuing through his corporate sponsored undergraduate and graduate years at Clarkson and Harvard Universities, resulting in 1965 in a doctorate in applied physics from the latter. He was subsequently assigned by IBM to its research division in San Jose (now Almaden), where he initially carried out both pure and applied theoretical and experimental investigations encompassing a broad range of company-related product technologies...storage, display, printer and data acquisition hardware and software. In 1973, he undertook performing DFT and quantum Monte Carlo calculations in support of group research in the then emerging field of organic and polymer superconductors, a very esoteric pursuit at the time. Following upon several corporate staff assignments involving various product development and sales strategies, in 1982 he was appointed manager of the cooperative phenomena group in the Almaden Research Center, which beginning in early 1987, made significant contributions to both the basic science and applications of high temperature superconductivity (HTSC). In 1993, after a 40-year career, he retired from IBM to accept a Science Fellow position at the Electric Power Research Institute (EPRI) where he funded power application development of superconductivity. In 2004, he retired from his EPRI career to undertake ``due diligence'' consulting services in support of the venture capital community in Silicon Valley. As a ``hobby,'' he currently pursues and publishes DFT studies in hope of discovering the pairing mechanism of HTSC. In summary, the speaker's career in industrial and applied physics demonstrates one can combine publishing a record three PRLs in one month with crawling around underground in substations with utility lineman helping install superconducting cables, along the way publishing 10

  11. Designing a handwashing station for infrastructure-restricted communities in Bangladesh using the integrated behavioural model for water, sanitation and hygiene interventions (IBM-WASH).

    Science.gov (United States)

    Hulland, Kristyna R S; Leontsini, Elli; Dreibelbis, Robert; Unicomb, Leanne; Afroz, Aasma; Dutta, Notan Chandra; Nizame, Fosiul Alam; Luby, Stephen P; Ram, Pavani K; Winch, Peter J

    2013-09-23

    In Bangladesh diarrhoeal disease and respiratory infections contribute significantly to morbidity and mortality. Handwashing with soap reduces the risk of infection; however, handwashing rates in infrastructure-restricted settings remain low. Handwashing stations--a dedicated, convenient location where both soap and water are available for handwashing--are associated with improved handwashing practices. Our aim was to identify a locally feasible and acceptable handwashing station that enabled frequent handwashing for two subsequent randomized trials testing the health effects of this behaviour. We conducted formative research in the form of household trials of improved practices in urban and rural Bangladesh. Seven candidate handwashing technologies were tested by nine to ten households each during two iterative phases. We conducted interviews with participants during an introductory visit and two to five follow up visits over two to six weeks, depending on the phase. We used the Integrated Behavioural Model for Water, Sanitation and Hygiene (IBM-WASH) to guide selection of candidate handwashing stations and data analysis. Factors presented in the IBM-WASH informed thematic coding of interview transcripts and contextualized feasibility and acceptability of specific handwashing station designs. Factors that influenced selection of candidate designs were market availability of low cost, durable materials that were easy to replace or replenish in an infrastructure-restricted and shared environment. Water storage capacity, ease of use and maintenance, and quality of materials determined the acceptability and feasibility of specific handwashing station designs. After examining technology, psychosocial and contextual factors, we selected a handwashing system with two different water storage capacities, each with a tap, stand, basin, soapy water bottle and detergent powder for pilot testing in preparation for the subsequent randomized trials. A number of contextual

  12. Revised Distances, Kinematics, and Classifications of the Nearest Stellar Groups within 100 pc

    Science.gov (United States)

    Mamajek, Eric E.

    2010-01-01

    Given the recent interest in assigning membership of low-mass or substellar field objects to clusters of "known" age, a modern analysis of the distances, kinematics, memberships, and physicality of purported nearby young stellar groups is needed. Van Leeuwen (2007) recently published a new astrometric analysis of data from the Hipparcos mission. Here I use the revised Hipparcos astrometry to estimate updated distances and parameters for the young stellar groups with obvious nuclei previously reported to lie within 100 pc of the Sun (except for the Hyades and Coma Ber, which were reported by van Leeuwen). Among the highlights of the results reported are: (1) the revised mean distances to the nuclei of the following groups: AB Dor (20.1+-1.5 pc), Ursa Major (25.2+-0.3 pc), Carina-Near (32.7+-1.2 pc), Tucana (43.0+-1.0 pc), TW Hya (52.7+-3.0 pc), 32 Ori (92.9+-2.4 pc), and eta Cha (94.3+-1.2 pc), (2) the 5-Myr-old epsilon Cha group appears to be the nearest known group associated with molecular gas (117+-4 pc), (3) the 8 Myr-old eta Cha cluster is the densest cluster within 100 pc ( 36 Msun/pc3), (4) the convergent point for the AB Dor group nucleus appears to be near its geometric center, a phenomena unique among nearby kinematic groups, and (5) the intrinsic 1D velocity dispersions of the nuclei are all remarkably similar (all 1 km/s), and are larger than that predicted assuming the nuclei are virialized (typically Polaris are probably unphysical. With refined kinematic parameters for the nearby stellar groups, one can now conduct a more refined membership analysis for others stars purported to be distant ``members'' of these groups.

  13. Expression and localization of prohormone convertase PC1 in the calcitonin-producing cells of the bullfrog ultimobranchial gland.

    Science.gov (United States)

    Yaoi, Yuichi; Suzuki, Masakazu; Tomura, Hideaki; Kurabuchi, Shingo; Sasayama, Yuichi; Tanaka, Shigeyasu

    2003-11-01

    We examined the expression and localization of the prohormone convertases, PC1 and PC2, in the ultimobranchial gland of the adult bullfrog using immunohistochemical (IHC) and in situ hybridization (ISH) techniques. In the ultimobranchial gland, PC1-immunoreactive cells were columnar, and were present in the follicular epithelium. When serial sections were immunostained with anti-calcitonin, anti-CGRP, anti-PC1, and anti-PC2 sera, PC1 was found only in the calcitonin/CGRP-producing cells. No PC2-immunopositive cells were detected. In the ISH, PC1 mRNA-positive cells were detected in the follicle cells in the ultimobranchial gland. No PC2 mRNA-positive cells were detected. RT-PCR revealed expression of the mRNAs of PC1 and the PC2 in the ultimobranchial gland. However, very little of the PC2 mRNA is probably translated because no PC2 protein was detected either by IHC staining or by Western blotting analysis. We conclude that the main prohormone convertase that is involved in the proteolytic cleavage of procalcitonin in the bullfrog is PC1.

  14. A computer program for planimetric analysis of digitized images

    DEFF Research Database (Denmark)

    Lynnerup, N; Lynnerup, O; Homøe, P

    1992-01-01

    bones as seen on X-rays. By placing the X-rays on a digitizer tablet and tracing the outline of the cell system, the area was calculated by the program. The calculated data and traced images could be stored and printed. The program is written in BASIC; necessary hardware is an IBM-compatible personal......Planimetrical measurements are made to calculate the area of an entity. By digitizing the entity the planimetrical measurements may be done by computer. This computer program was developed in conjunction with a research project involving measurement of the pneumatized cell system of the temporal...... computer, a digitizer tablet and a printer....

  15. IBM-type inclusions in a patient with slow-channel syndrome caused by a mutation in the AChR epsilon subunit.

    Science.gov (United States)

    Fidzianska, Anna; Ryniewicz, B; Shen, Xing-Ming; Engel, Andrew G

    2005-11-01

    We report a patient with a slow-channel congenital myasthenic syndrome who carries a novel slow-channel mutation in the epsilon subunit of the acetylcholine receptor and has tubulofilamentous inclusion bodies, in skeletal muscle of the type observed in hereditary and sporadic inclusion body myositis. Ultrastructural analysis of a muscle specimen obtained at the age of 9 years showed an endplate myopathy typical of the slow-channel syndrome. Twenty years later, a second muscle specimen again showed the endplate myopathy as well numerous nuclear and cytoplasmic tubulofilamentous inclusion bodies. Molecular genetic studies revealed a novel valine to phenylalanine mutation (epsilonV259F) in the M2 domain of the acetylcholine receptor. Coexistence of the slow-channel syndrome with a feature of IBM has not been observed before.

  16. Reengineering a PC-based System into the Mobile Device Product Line

    DEFF Research Database (Denmark)

    Zhang, Weishan; Jarzabek, Stanislaw; Loughran, Neil

    2003-01-01

    devices must also perform well using less memory than PC-based systems. Mobile devices themselves are different from each other in many ways, too. We describe how we made an existing PC-based City Guide System available on a wide range of mobile devices, in a cost-effective way. We applied "reengineering...

  17. Physical and Mechanical Characteristics of Kevlar Fiber-Reinforced PC/ABS Composites

    Directory of Open Access Journals (Sweden)

    Kuljira Sujirote

    2012-01-01

    Full Text Available In this research, the composites between polycarbonate (PC and acrylonitrile-butadiene-styrene (ABS alloy and Kevlar fiber were prepared. The flexural and tensile properties of PC/ABS alloy and its composites were determined using a universal testing machine. The synergistic behavior of flexural modulus was observed for all regions of PC contents, while the synergism of flexural strength and tensile strength were found in some PC contents. It was found that the optimum weight ratio of PC:ABS was 60:40. In the Kevlar Fiber-reinforced PC/ABS composite system at PC:ABS of 60:40, both flexural modulus and strength were increased with matrix contents. Additionally, the flexural strength drastically increased with the matrix content and then reached the maximum value of 167 MPa at the matrix content of 33.4 wt%. The results from peel test, water contact measurement, and scanning electron microscopy (SEM reveal that the interfacial adhesion between the Kevlar fiber and the polymer matrix could be improved by increasing the PC content in the matrix.

  18. Novel Mutations in the PC Gene in Patients with Type B Pyruvate Carboxylase Deficiency

    DEFF Research Database (Denmark)

    Ostergaard, Elsebet; Duno, Morten; Møller, Lisbeth Birk

    2013-01-01

    mutations with the severe type B deficiency, clinically indistinguishable from other patients with type B form of PC deficiency.The mutations found here are novel; it is noteworthy that four Turkish patients did not have any mutations in common, despite the rarity of PC deficiency. There is thus no evidence...

  19. Multipoint Observations of Low Latitude ULF Pc3 Waves in South ...

    Indian Academy of Sciences (India)

    The solar wind provides the energy for the earth's magne- tospheric processes. Pc3-5 geomagnetic pulsations can be generated either externally or internally with respect to the magnetosphere. The Pc3 studies undertaken in the past have been confined to middle and high latitudes. The spatial and temporal variations ...

  20. Functional roles of PC-PLC and Cdc20 in the cell cycle, proliferation, and apoptosis.

    Science.gov (United States)

    Chen, Zhiwei; Yu, Yongfeng; Fu, Da; Li, Ziming; Niu, Xiaoming; Liao, Meilin; Lu, Shun

    2010-06-01

    Phosphatidylcholine-specific phospholipase C (PC-PLC) is the major enzyme in the Phosphatidylcholine (PC) cycle and is involved in many long-term cellular responses such as activation, proliferation, and differentiation events. Cell division cycle 20 homolog (Cdc20) is an essential cell-cycle regulator required for the completion of mitosis. Our previous studies identified the interaction between PC-PLC and Cdc20. Through the interaction, Cdc20 could mediate the degradation of PC-PLC by Cdc20-mediated ubiquitin proteasome pathway (UPP). In this study, we found that PC-PLC might not be involved in cancer metastasis. Inhibition of PC-PLC by D609 could cause cell proliferation inhibition and apoptosis inhibition in CBRH-7919 cells. Inhibition of PC-PLC could also influence the cell cycle by arresting the cells in G1 phase, and Cdc20 might be involved in these processes. Taken together, in this report, we provided new evidence for the functional roles of PC-PLC and Cdc20 in the cell cycle, proliferation, and apoptosis in CBRH-7919 cells. 2010 John Wiley & Sons, Ltd.

  1. Effective polar cap area and multi-station basis for Polar Cap (PC) indices

    Science.gov (United States)

    Stauning, Peter

    2017-04-01

    The Polar Cap (PC) indices are useful indices for Space Weather forecasts and analyses. The PC indices have been used to monitor the interplanetary geoeffective electric field and solar wind pressure pulses, to analyze cross polar cap voltages, polar cap diameter, and general polar cap dynamics. Furthermore, the PC indices have been used to monitor auroral electrojet intensities, ionospheric Joule heating, and global auroral power, and to predict ring current intensities. For specific Space Weather warning forecasts the PC indices can be used to predict substorm development and the associated risk of power line disturbances in the subauroral regions. The PC indices, PCN (North) and PCS (South), are derived from geomagnetic observations at Thule in Greenland and Vostok in Antarctica, respectively. In order to provide reliable forecast services based on PC indices, it would be advantageous to have available back-up suppliers of index values. The presentation provides an analysis of the effective area for useful PC index derivation and suggests observatories that could provide back-up data for PC index calculations should the primary sources fail due to instrument or communication problems.

  2. 21 CFR 868.2500 - Cutaneous oxygen (PcO2) monitor.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Cutaneous oxygen (PcO2) monitor. 868.2500 Section...) monitor. (a) Identification. A cutaneous oxygen (PcO2) monitor is a noninvasive, heated sensor (e.g., a Clark-type polargraphic electrode) placed on the patient's skin that is intended to monitor relative...

  3. 21 CFR 868.2480 - Cutaneous carbon dioxide (PcCO2) monitor.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Cutaneous carbon dioxide (PcCO2) monitor. 868.2480...CO2) monitor. (a) Identification. A cutaneous carbon dioxide (PcCO2) monitor is a noninvasive heated sensor and a pH-sensitive glass electrode placed on a patient's skin, which is intended to monitor...

  4. Application of PC-CREAM in the Netherlands - Dose impact due to atmospheric releases

    NARCIS (Netherlands)

    Eleveld H; Twenhofel CJW; Pruppers MJM; LSO

    1999-01-01

    CREAM, een model om de radiologische consequenties van reguliere lozingen te bepalen, is ontwikkeld door National Radiological Protection Board (UK). PC-CREAM, de PC-implementatie van het model, is vergeleken met de Nederlandse richtlijn. Voor twee specifieke referentiesituaties en elf natuurlijk

  5. Cost and quality planning for large NASA programs

    Science.gov (United States)

    Rone, Kyle Y.

    1990-01-01

    The Software Cost and Quality Engineering methodology developed over the last two decades at IBM Federal Sector Div. is used to plan the NASA Space Station Data Management System (DMS). An ongoing project to capture this methodology, which is built on a foundation of experiences and lessons learned, has resulted in the development of a PC-based tool that integrates cost and quality forecasting methodologies and data in a consistent manner. This tool, Software Cost and Quality Engineering Starter Set (SCQESS), is being used to assist in the DMS costing exercises. At the same time, DMS planning serves as a forcing function and provides a platform for the continuing, iterative development, calibration, and validation and verification of SCQESS. The data that forms the cost and quality engineering data base is derived from more than 17 years of development of NASA Space Shuttle software, ranging from low criticality, low complexity support tools to highly complex and highly critical onboard software.

  6. Particular electronic properties of F{sub 16}CoPc: A decent electron acceptor material

    Energy Technology Data Exchange (ETDEWEB)

    Rückerl, Florian, E-mail: f.rueckerl@ifw-dresden.de; Waas, Daniel; Büchner, Bernd; Knupfer, Martin, E-mail: m.knupfer@ifw-dresden.de

    2017-02-15

    Highlights: • Hole doping of various surfaces by F{sub 16}CoPc. • Reduction of Cobalt center. • Potential surface functionalization by F{sub 16}CoPc in many other cases. - Abstract: Various interfaces with F{sub 16}CoPc as one of the partners are characterized by a charge transfer across the interface and a concomitant reduction of the Co central atom in these molecules. We summarize recent photoemission spectroscopy results and compare those to the data from equivalent interfaces comprising F{sub 16}CuPc. In the latter, the Cu center remains unchanged indicating the particular role of Co in F{sub 16}CoPc as the electron accepting site.

  7. Dissection of the functional structure of aptamer17, which specifically recognizes differentiated PC12 cells.

    Science.gov (United States)

    Liu, Jiao-Jiao; Wang, Cheng-Long; Xi, Qing; Xu, Juan; Deng, Bin; Ding, Hong-Mei; Chu, Bingfeng; Su, Dong-Hua

    2011-06-01

    A specific single-stranded DNA (ssDNA) aptamer (aptamer17) that specifically recognizes differentiated PC12 cells had been previously obtained after 6 rounds of whole cell-based subtractive systematic evolution of ligands by exponential enrichment selection from a random ssDNA library. To further investigate the relationship between the structure and function of this aptamer, 3 truncated ssDNA aptamers were designed according to the predicted secondary structure of aptamer17. Our results show that the stem-loop is the core structure of the aptamers required for specific binding to differentiated PC12 cells, specifically loops I and II. Aptamer17 and the truncated aptamers with this basic structure could bind specifically to differentiated PC12 cells and identify these cells from a mixture of differentiated and undifferentiated PC12 cells. Therefore, truncated forms of aptamer17 may be useful in the clinic to identify undifferentiated and differentiated PC12 cells from a mixture of cells.

  8. [Grape seed extract inhibits the growth of prostate cancer PC-3 cells].

    Science.gov (United States)

    Huang, Ting-Ting; Shang, Xue-Jun; Yao, Gen-Hong; Ge, Jing-Ping; Teng, Wen-Hui; Sun, Yi; Huang, Yu-Feng

    2008-04-01

    To investigate the inhibitory effect of grape seed extract (GSE) on the growth of prostate cancer PC-3 cells. PC-3 cells were treated with GSE at the concentration of 100, 200 and 300 microg/ml for 24, 48 and 72 hours, respectively. The the inhibitory effect of GSE on the growth of the PC-3 cells and the kidney cells of SD rats was determined by MTT reduction assay, with primarily cultured kidney cells of 1-3 days old SD rats as the normal control. GSE significantly inhibited the growth of PC-3 cells in a concentration- and time-dependent manner, but had only a mild inhibitory effect on the kidney cells. GSE inhibits the growth of prostate cancer PC-3 cells and can be used as a new drug for the treatment of prostate cancer.

  9. REFLEAK: NIST Leak/Recharge Simulation Program for Refrigerant Mixtures

    Science.gov (United States)

    SRD 73 NIST REFLEAK: NIST Leak/Recharge Simulation Program for Refrigerant Mixtures (PC database for purchase)   REFLEAK estimates composition changes of zeotropic mixtures in leak and recharge processes.

  10. STREAK CAMERA MEASUREMENTS OF THE APS PC GUN DRIVE LASER

    Energy Technology Data Exchange (ETDEWEB)

    Dooling, J. C.; Lumpkin, A. H.

    2017-06-25

    We report recent pulse-duration measurements of the APS PC Gun drive laser at both second harmonic and fourth harmonic wavelengths. The drive laser is a Nd:Glass-based chirped pulsed amplifier (CPA) operating at an IR wavelength of 1053 nm, twice frequency-doubled to obtain UV output for the gun. A Hamamatsu C5680 streak camera and an M5675 synchroscan unit are used for these measurements; the synchroscan unit is tuned to 119 MHz, the 24th subharmonic of the linac s-band operating frequency. Calibration is accomplished both electronically and optically. Electronic calibration utilizes a programmable delay line in the 119 MHz rf path. The optical delay uses an etalon with known spacing between reflecting surfaces and is coated for the visible, SH wavelength. IR pulse duration is monitored with an autocorrelator. Fitting the streak camera image projected profiles with Gaussians, UV rms pulse durations are found to vary from 2.1 ps to 3.5 ps as the IR varies from 2.2 ps to 5.2 ps.

  11. KCl stimulation increases norepinephrine transporter function in PC12 cells.

    Science.gov (United States)

    Mandela, Prashant; Ordway, Gregory A

    2006-09-01

    The norepinephrine transporter (NET) plays a pivotal role in terminating noradrenergic signaling and conserving norepinephrine (NE) through the process of re-uptake. Recent evidence suggests a close association between NE release and regulation of NET function. The present study evaluated the relationship between release and uptake, and the cellular mechanisms that govern these processes. KCl stimulation of PC12 cells robustly increased [3H]NE uptake via the NET and simultaneously increased [3H]NE release. KCl-stimulated increases in uptake and release were dependent on Ca2+. Treatment of cells with phorbol-12-myristate-13-acetate (PMA) or okadaic acid decreased [3H]NE uptake but did not block KCl-stimulated increases in [3H]NE uptake. In contrast, PMA increased [3H]NE release and augmented KCl-stimulated release, while okadaic acid had no effects on release. Inhibition of Ca2+-activated signaling cascades with KN93 (a Ca2+ calmodulin-dependent kinase inhibitor), or ML7 and ML9 (myosin light chain kinase inhibitors), reduced [3H]NE uptake and blocked KCl-stimulated increases in uptake. In contrast, KN93, ML7 and ML9 had no effect on KCl-stimulated [3H]NE release. KCl-stimulated increases in [3H]NE uptake were independent of transporter trafficking to the plasma membrane. While increases in both NE release and uptake mediated by KCl stimulation require Ca2+, different intracellular mechanisms mediate these two events.

  12. Interaction With PC Tablets And Possible Emotional Responses

    Directory of Open Access Journals (Sweden)

    Emy Agren

    2015-08-01

    Full Text Available The remarkable developments in mobile-based technologies have brought prominent impacts on human life style. Today life is running on mobile electronic devices smart phones tablets gaming devices and video-players. Generally the users acquaint with the features and properties of products after emotionally and physically interacting with the devices. The interaction in return influencing our moods depending on the feelings the technology creates. The focus of this study lays on the uses of tablets or also called PC tablets and its effects on its users emotional responses. To discover possible emotional responses with the tablets the data in this work were collected through a survey questionnaire from participants belongs to various backgrounds age groups and genders. The model of emotions was adopted in order to classify the emotional responses.The study has found that during or after the interaction with the tablets the users may get positive or negative emotional responses of a different kind. The users mood can also be affected by awakening such emotional feelings as happiness sadness frustration etc.

  13. The NA48 on-line PC farm

    CERN Document Server

    Wittgen, M

    2001-01-01

    The NA48 experiment at the CERN SPS measures the direct CP violation parameter Re( epsilon '/z) in the neutral kaon system with an intended precision of 2*10/sup -4/. Thus, the data acquisition system has to handle peak rates up to 150 MByte/s during a 2.5 s beam burst and flat rates up to 20 MByte/s during on-line processing. The NA48 on-line PC farm includes 24 PentiumII-266 MHz PCs connected via switched fast ethernet network. This farm receives data from the detector systems and performs event building. Afterwards the data are transferred via an optical gigabit ethernet link to the NA48 central data recording system at CERN computer center. In addition, trigger and checking processes can be applied. The software on the farm is implemented as client/server applications and represents a highly flexible, fail safe, and scalable system. During data taking, in 1999, 100 TByte were collected, processed, and stored by the acquisition system with an overall efficiency of 99%. (5 refs).

  14. Accelerating Popular Tomographic Reconstruction Algorithms on Commodity PC Graphics Hardware

    Science.gov (United States)

    Xu, Fang; Mueller, K.

    2005-06-01

    The task of reconstructing an object from its projections via tomographic methods is a time-consuming process due to the vast complexity of the data. For this reason, manufacturers of equipment for medical computed tomography (CT) rely mostly on special application specified integrated circuits (ASICs) to obtain the fast reconstruction times required in clinical settings. Although modern CPUs have gained sufficient power in recent years to be competitive for two-dimensional (2D) reconstruction, this is not the case for three-dimensional (3D) reconstructions, especially not when iterative algorithms must be applied. The recent evolution of commodity PC computer graphics boards (GPUs) has the potential to change this picture in a very dramatic way. In this paper we will show how the new floating point GPUs can be exploited to perform both analytical and iterative reconstruction from X-ray and functional imaging data. For this purpose, we decompose three popular three-dimensional (3D) reconstruction algorithms (Feldkamp filtered backprojection, the simultaneous algebraic reconstruction technique, and expectation maximization) into a common set of base modules, which all can be executed on the GPU and their output linked internally. Visualization of the reconstructed object is easily achieved since the object already resides in the graphics hardware, allowing one to run a visualization module at any time to view the reconstruction results. Our implementation allows speedups of over an order of magnitude with respect to CPU implementations, at comparable image quality.

  15. A fast PC algorithm for high dimensional causal discovery with multi-core PCs.

    Science.gov (United States)

    Le, Thuc; Hoang, Tao; Li, Jiuyong; Liu, Lin; Liu, Huawen; Hu, Shu

    2016-07-14

    Discovering causal relationships from observational data is a crucial problem and it has applications in many research areas. The PC algorithm is the state-of-the-art constraint based method for causal discovery. However, runtime of the PC algorithm, in the worst-case, is exponential to the number of nodes (variables), and thus it is inefficient when being applied to high dimensional data, e.g. gene expression datasets. On another note, the advancement of computer hardware in the last decade has resulted in the widespread availability of multi-core personal computers. There is a significant motivation for designing a parallelised PC algorithm that is suitable for personal computers and does not require end users' parallel computing knowledge beyond their competency in using the PC algorithm. In this paper, we develop parallel-PC, a fast and memory efficient PC algorithm using the parallel computing technique. We apply our method to a range of synthetic and real-world high dimensional datasets. Experimental results on a dataset from the DREAM 5 challenge show that the original PC algorithm could not produce any results after running more than 24 hours; meanwhile, our parallel-PC algorithm managed to finish within around 12 hours with a 4-core CPU computer, and less than 6 hours with a 8-core CPU computer. Furthermore, we integrate parallel-PC into a causal inference method for inferring miRNA-mRNA regulatory relationships. The experimental results show that parallel-PC helps improve both the efficiency and accuracy of the causal inference algorithm.

  16. Loss of the DNA methyltransferase MET1 Induces H3K9 hypermethylation at PcG target genes and redistribution of H3K27 trimethylation to transposons in Arabidopsis thaliana.

    Directory of Open Access Journals (Sweden)

    Angelique Deleris

    Full Text Available Dimethylation of histone H3 lysine 9 (H3K9m2 and trimethylation of histone H3 lysine 27 (H3K27m3 are two hallmarks of transcriptional repression in many organisms. In Arabidopsis thaliana, H3K27m3 is targeted by Polycomb Group (PcG proteins and is associated with silent protein-coding genes, while H3K9m2 is correlated with DNA methylation and is associated with transposons and repetitive sequences. Recently, ectopic genic DNA methylation in the CHG context (where H is any base except G has been observed in globally DNA hypomethylated mutants such as met1, but neither the nature of the hypermethylated loci nor the biological significance of this epigenetic phenomenon have been investigated. Here, we generated high-resolution, genome-wide maps of both H3K9m2 and H3K27m3 in wild-type and met1 plants, which we integrated with transcriptional data, to explore the relationships between these two marks. We found that ectopic H3K9m2 observed in met1 can be due to defects in IBM1-mediated H3K9m2 demethylation at some sites, but most importantly targets H3K27m3-marked genes, suggesting an interplay between these two silencing marks. Furthermore, H3K9m2/DNA-hypermethylation at these PcG targets in met1 is coupled with a decrease in H3K27m3 marks, whereas CG/H3K9m2 hypomethylated transposons become ectopically H3K27m3 hypermethylated. Our results bear interesting similarities with cancer cells, which show global losses of DNA methylation but ectopic hypermethylation of genes previously marked by H3K27m3.

  17. Reduction of seismic response long-span PC cable-stayed bridge by passive dampers; Damper ni yoru saidai PC shachokyo no jishinji oto no teigen

    Energy Technology Data Exchange (ETDEWEB)

    Takeda, T.; Yamanobe, S.; Niihara, Y. [Kajima Corp., Tokyo (Japan)

    1994-10-31

    It is important in designing a PC cable-stayed bridge to properly estimate the seismic response of the bridge for reduction of the response. In this paper, an improvement of the seismic resistance of PC cable-stayed bridges when dampers are installed between the deck and piers and lateral vibration of the deck is restricted is investigated using a time history response model. PC cable-stayed bridges with a span length of 400 m, particularly two types of bridges of harp and semi-harp are investigated and the following is found by analyzing the case where there are installed hysteresis type dampers (with 1 cm yield displacement and secondary rigidity assumed to be 1/10 times that of initial rigidity, the initial rigidity being parametrically changed.) or viscous type dampers (a damping factor is changed.) The result shows that the dampers can reduce the seismic response of a PC cable-stayed bridge and that a semi-harp configuration of stay cables where stay cable members are substantially vertically arranged is more effective than a harp configuration for the seismic performance of PC cable-stayed bridges. The damper partly bear inertial force of the bridge upon earthquake whereby tension of the stay cable members is reduced and bending moment of the deck is reduced. There is existing an optimum characteristic value of the damper concerning the bending moment of the piers. 5 refs., 7 figs., 2 tabs.

  18. IbM PENGEMBANGAN KEPROFESIAN BERKELANJUTAN (PKB GURU-GURU MIM WILAYAH NGAWEN DAN KLATEN UTARA BERBASIS KURIKULUM 2013

    Directory of Open Access Journals (Sweden)

    Laili Etika Rahmawati

    2015-09-01

    Full Text Available The society service has aimed at accompanying the teachers on understanding and conducting the program of sustainable professionalism development (PKB based on curriculum 2013. When the society service program has finished conducted, it is expected to acquire the four goals as follow: (1 the emergence of a professional teacher group and acquire the teaching competence by implementing the active learning strategy with scientific approach based on curriculum 2013; (2 the learning devices based on curriculum 2013; (3 the research proposal is classroom action research; and (4 the scientific publication article. The method applied in the society service program was conducted with the same model as the PLPG program conducted but the program implementation was simpler or could be called as mini PLPG. The program activity was beginned by deepening of material activity which related to the concept of PKB and the concept of curriculum 2013. The concept of PKB emphasized on three points that should be developed by the teachers, they were the self development, scientific publication, and innovative work. The concept of curriculum 2013 has priority on the changing understanding of the paradigm and the basic concept of curriculum structure, the prominent were about the core and the basic competences. After the deepening materials which conducted in the first phase has finished, the activity then continued by the workshop of the learning devices which emphasized on the concept of scientific approach, the active learning, and the authentic assessment which followed by peer teaching activity. The worshop activity of learning devices was conducted by facilitating the teachers in arranging the learning scenario based on the materials determined. The peer teaching activity was conducted by divide the participants into some groups to conduct the teaching practice by turns and apply the scientific approach. The third phase was the arranging the academic writing, and

  19. Low NOx Burner Design and Analysis for Conceptual Design of Oxygen-Based PC Boiler

    Energy Technology Data Exchange (ETDEWEB)

    Andrew Seltzer

    2005-05-01

    The objective of the low NOx burner design and analysis task of the Conceptual Design of Oxygen-Based PC Boiler study is to optimize the burner design to ensure stable ignition, to provide safe operation, and to minimize pollutant formation. The burners were designed and analyzed using the Fluent computer program. Four burner designs were developed: (1) with no over-fire gas (OFG) and 65% flue gas recycle, (2) with 20% OFG and 65% flue gas recycle, (3) with no OFG and 56% flue gas recycle and (4) with 20% OFG and 56% flue gas recycle. A 3-D Fluent simulation was made of a single wall-fired burner and horizontal portion of the furnace from the wall to the center. Without primary gas swirl, coal burnout was relatively small, due to the low oxygen content of the primary gas stream. Consequently, the burners were modified to include primary gas swirl to bring the coal particles in contact with the secondary gas. An optimal primary gas swirl was chosen to achieve sufficient burnout.

  20. Validation and verification of the MTR{sub P}C thermohydraulic package

    Energy Technology Data Exchange (ETDEWEB)

    Doval, Alicia [INVAP S.E., Bariloche, Rio Negro (Argentina). Nuclear Engineering Dept.]. E-mail: doval@invap.com.ar

    1998-07-01

    The MTR{sub P}C v2.6 is a computational package developed for research reactor design and calculation. It covers three of the main aspects of a research reactor: neutronic, shielding and thermohydraulic. In this work only the thermohydraulic package will be covered, dealing with verification and validation aspects. The package consists of the following steady state programs: CAUDVAP 2.60 for the hydraulic calculus, estimates the velocity distribution through different parallel channels connected to a common inlet and outlet common plenum. TERMIC 1H v3.0, used for the thermal design of research reactors, provides information about heat flux for a given maximum wall temperature, onset of nucleate boiling, redistribution phenomena and departure from nucleate boiling. CONVEC V3.0 allows natural convection calculations, giving information on heat fluxes for onset of nucleate boiling, pulsed and burn-out phenomena as well as total coolant flow. Results have been validated against experimental values and verified against theoretical and computational programmes results, showing a good agreement. (author)

  1. A Fast CT Reconstruction Scheme for a General Multi-Core PC

    Directory of Open Access Journals (Sweden)

    Kai Zeng

    2007-01-01

    Full Text Available Expensive computational cost is a severe limitation in CT reconstruction for clinical applications that need real-time feedback. A primary example is bolus-chasing computed tomography (CT angiography (BCA that we have been developing for the past several years. To accelerate the reconstruction process using the filtered backprojection (FBP method, specialized hardware or graphics cards can be used. However, specialized hardware is expensive and not flexible. The graphics processing unit (GPU in a current graphic card can only reconstruct images in a reduced precision and is not easy to program. In this paper, an acceleration scheme is proposed based on a multi-core PC. In the proposed scheme, several techniques are integrated, including utilization of geometric symmetry, optimization of data structures, single-instruction multiple-data (SIMD processing, multithreaded computation, and an Intel C++ compilier. Our scheme maintains the original precision and involves no data exchange between the GPU and CPU. The merits of our scheme are demonstrated in numerical experiments against the traditional implementation. Our scheme achieves a speedup of about 40, which can be further improved by several folds using the latest quad-core processors.

  2. Numerical analysis of resonances induced by s wave neutrons in transmission time-of-flight experiments with a computer IBM 7094 II; Methodes d'analyse des resonances induites par les neutrons s dans les experiences de transmission par temps de vol et automatisation de ces methodes sur ordinateur IBM 7094 II

    Energy Technology Data Exchange (ETDEWEB)

    Corge, Ch. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1969-01-01

    Numerical analysis of transmission resonances induced by s wave neutrons in time-of-flight experiments can be achieved in a fairly automatic way on an IBM 7094/II computer. The involved computations are carried out following a four step scheme: 1 - experimental raw data are processed to obtain the resonant transmissions, 2 - values of experimental quantities for each resonance are derived from the above transmissions, 3 - resonance parameters are determined using a least square method to solve the over determined system obtained by equalling theoretical functions to the correspondent experimental values. Four analysis methods are gathered in the same code, 4 - graphical control of the results is performed. (author) [French] L'automatisation, sur ordinateur IBM 7094/II, de l'analyse des resonances induites par les neutrons s dans les experiences de transmission par temps de vol a ete accomplie en la decomposant selon un schema articule en quatre phases: 1 - le traitement des donnees experimentales brutes pour obtenir les transmissions interfero-resonnantes, 2 - la determination des grandeurs d'analyse a partir des transmissions precedentes, 3 - l'analyse proprement dite des resonances dont les parametres sont obtenus par la resolution d'un systeme surabondant. Quatre methodes d'analyse sont groupees en un meme programme, 4 - la procedure de verification graphique. (auteur)

  3. APC-PC Combined Scheme in Gilbert Two State Model: Proposal and Study

    Science.gov (United States)

    Bulo, Yaka; Saring, Yang; Bhunia, Chandan Tilak

    2017-04-01

    In an automatic repeat request (ARQ) scheme, a packet is retransmitted if it gets corrupted due to transmission errors caused by the channel. However, an erroneous packet may contain both erroneous bits and correct bits and hence it may still contain useful information. The receiver may be able to combine this information from multiple erroneous copies to recover the correct packet. Packet combining (PC) is a simple and elegant scheme of error correction in transmitted packet, in which two received copies are XORed to obtain the bit location of erroneous bits. Thereafter, the packet is corrected by bit inversion of bit located as erroneous. Aggressive packet combining (APC) is a logic extension of PC primarily designed for wireless communication with objective of correcting error with low latency. PC offers higher throughput than APC, but PC does not correct double bit errors if occur in same bit location of erroneous copies of the packet. A hybrid technique is proposed to utilize the advantages of both APC and PC while attempting to remove the limitation of both. In the proposed technique, applications of APC-PC on Gilbert two state model has been studied. The simulation results show that the proposed technique offers better throughput than the conventional APC and lesser packet error rate than PC scheme.

  4. Impact of a Recombinant Biocontrol Bacterium, Pseudomonas fluorescens pc78, on Microbial Community in Tomato Rhizosphere.

    Science.gov (United States)

    Kong, Hyun Gi; Kim, Nam Hee; Lee, Seung Yeup; Lee, Seon-Woo

    2016-04-01

    Pseudomonas fluorescens pc78 is an effective biocontrol agent for soil-borne fungal diseases. We previously constructed a P43-gfp tagged biocontrol bacteria P. fluorescens pc78-48 to investigate bacterial traits in natural ecosystem and the environmental risk of genetically modified biocontrol bacteria in tomato rhizosphere. Fluctuation of culturable bacteria profile, microbial community structure, and potential horizontal gene transfer was investigated over time after the bacteria treatment to the tomato rhizosphere. Tagged gene transfer to other organisms such as tomato plants and bacteria cultured on various media was examined by polymerase chain reaction, using gene specific primers. Transfer of chromosomally integrated P43-gfp from pc78 to other organisms was not apparent. Population and colony types of culturable bacteria were not significantly affected by the introduction of P. fluorescens pc78 or pc78-48 into tomato rhizosphere. Additionally, terminal restriction fragment length polymorphism profiles were investigated to estimate the influence on the microbial community structure in tomato rhizosphere between non-treated and pc78-48-treated samples. Interestingly, rhizosphere soil treated with strain pc78-48 exhibited a significantly different bacterial community structure compared to that of non-treated rhizosphere soil. Our results suggest that biocontrol bacteria treatment influences microbial community in tomato rhizosphere, while the chromosomally modified biocontrol bacteria may not pose any specific environmental risk in terms of gene transfer.

  5. The effect of modulating top-down attention deployment on the N2pc/PCN.

    Science.gov (United States)

    Liu, Qiang; Lin, Shuyu; Zhao, Guang; Roberson, Debi

    2016-05-01

    The N2pc (PCN) component of the event-related potential (ERP) waveform provides a useful tool for directly assessing the locus of spatial attention in visual search. It is still unclear whether the amplitude of the N2pc/PCN relates to the deployment of attentional resources. A key issue is the lack of evidence that top-down allocation of attention affects the N2pc/PCN amplitude. Previous findings could be explained if manipulating different expectancy strategies changes participants' search mode, causing them to redefine the target's features. In this study, we explored the relationship between N2pc/PCN amplitude and top-down attention allocation by manipulating the discriminative difficulty (differences in the response-defining feature) but leaving the search difficulty (target's saliency) unchanged. Using the same sets of stimuli, in a blocked condition, participants showed the expected higher amplitude of N2pc/PCN in the hardest condition, compared to easier discrimination conditions. Importantly, there was no difference in the N2pc/PCN when the exact same stimulus sets were presented in a randomly interleaved mixed set. At a behavioral level, in both conditions performance was significantly slower for the hardest condition. This finding indicates that the N2pc/PCN component is modulated by the predictability of discriminative difficulty, which reflects the modulation of top-down attentional deployment. Copyright © 2016 Elsevier B.V. All rights reserved.

  6. Effect of thermoplastic polyurethane content on properties of PC/TPU blend filled with Montmorillonite

    Directory of Open Access Journals (Sweden)

    G. M. Shashidhara

    2013-03-01

    Full Text Available The present study was taken up to investigate the effect of addition of Montmorillonite (MMT to Polycarbonate/Thermoplastic polyurethane (PC/TPU blends. A master batch of PC/MMT (70/30 was prepared using Hake Rheomixer and PC/TPU blends filled with MMT of different compositions (90/10/5, 80/20/5, 70/30/5 were prepared by melt mixing using required quantities of master batch, PC and TPU in a twin screw extruder (TSE. Blends of PC/TPU of similar compositions (without MMT were also prepared using twin screw extruder. The test specimens were prepared by injection molding. The samples were characterized in terms of mechanical (as per relevant ASTM standards, thermal and dynamic mechanical properties. It was observed that addition of 5 phb of MMT to PC/TPU system improves tensile strength by 34 %, flexural strength by 8.6 % and flexural modulus by 16.7 %, storage modulus by 25 % and Shore D hardness by 16 % in all the compositions containing MMT. Differencial Scanning Calorimetric (DSC and Dynamic Mechanical Analysis (DMA studies revealed that the Tg shift towards lower values when compared with neat PC.The heat deflection temperature (HDT of blends with MMT was found to increase with the reinforcement.

  7. Isoform 1 of TPD52 (PC-1) promotes neuroendocrine transdifferentiation in prostate cancer cells

    KAUST Repository

    Moritz, Tom

    2016-02-05

    The tumour protein D52 isoform 1 (PC-1), a member of the tumour protein D52 (TPD52) protein family, is androgen-regulated and prostate-specific expressed. Previous studies confirmed that PC-1 contributes to malignant progression in prostate cancer with an important role in castration-resistant stage. In the present work, we identified its impact in mechanisms leading to neuroendocrine (NE) transdifferentiation. We established for long-term PC-1 overexpression an inducible expression system derived from the prostate carcinoma cell line LNCaP. We observed that PC-1 overexpression itself initiates characteristics of neuroendocrine cells, but the effect was much more pronounced in the presence of the cytokine interleukin-6 (IL-6). Moreover, to our knowledge, this is the first report that treatment with IL-6 leads to a significant upregulation of PC-1 in LNCaP cells. Other TPD52 isoforms were not affected. Proceeding from this result, we conclude that PC-1 overexpression enhances the IL-6-mediated differentiation of LNCaP cells into a NE-like phenotype, noticeable by morphological changes and increased expression of typical NE markers, like chromogranin A, synaptophysin or beta-3 tubulin. Immunofluorescent staining of IL-6-treated PC-1-overexpressing LNCaP cells indicates a considerable PC-1 accumulation at the end of the long-branched neuron-like cell processes, which are typically formed by NE cells. Additionally, the experimentally initiated NE transdifferentiation correlates with the androgen receptor status, which was upregulated additively. In summary, our data provide evidence for an involvement of PC-1 in NE transdifferentiation, frequently associated with castration resistance, which is a major therapeutic challenge in the treatment of advanced prostate cancer.

  8. Training the Workforce: Description of a Longitudinal Interdisciplinary Education and Mentoring Program in Palliative Care.

    Science.gov (United States)

    Levine, Stacie; O'Mahony, Sean; Baron, Aliza; Ansari, Aziz; Deamant, Catherine; Frader, Joel; Leyva, Ileana; Marschke, Michael; Preodor, Michael

    2017-04-01

    The rapid increase in demand for palliative care (PC) services has led to concerns regarding workforce shortages and threats to the resiliency of PC teams. To describe the development, implementation, and evaluation of a regional interdisciplinary training program in PC. Thirty nurse and physician fellows representing 22 health systems across the Chicago region participated in a two-year PC training program. The curriculum was delivered through multiple conferences, self-directed e-learning, and individualized mentoring by expert local faculty (mentors). Fellows shadowed mentors' clinical practices and received guidance on designing, implementing, and evaluating a practice improvement project to address gaps in PC at their institutions. Enduring, interdisciplinary relationships were built at all levels across health care organizations. Fellows made significant increases in knowledge and self-reported confidence in adult and pediatric PC and program development skills and frequency performing these skills. Fellows and mentors reported high satisfaction with the educational program. This interdisciplinary PC training model addressed local workforce issues by increasing the number of clinicians capable of providing PC. Unique features include individualized longitudinal mentoring, interdisciplinary education, on-site project implementation, and local network building. Future research will address the impact of the addition of social work and chaplain trainees to the program. Copyright © 2017 American Academy of Hospice and Palliative Medicine. Published by Elsevier Inc. All rights reserved.

  9. Functional magnetic resonance maps obtained by personal computer; Mapas de resonancia magnetica funcional obtenidos con PC

    Energy Technology Data Exchange (ETDEWEB)

    Gomez, F. j.; Manjon, J. V.; Robles, M. [Universidad Politecnica de Valencia (Spain); Marti-Bonmati, L.; Dosda, R. [Cinica Quiron. Valencia (Spain); Molla, E. [Universidad de Valencia (Spain)

    2001-07-01

    Functional magnetic resonance (fMR) is of special relevance in the analysis of certain types of brain activation. The present report describes the development of a simple software program for use with personal computers (PCs) that analyzes these images and provides functional activation maps. Activation maps are based on the temporal differences in oxyhemoglobin in tomographic images. To detect these differences, intensities registered repeatedly during brain control and activation are compared. The experiments were performed with a 1.5-Tesla MR unit. To verify the reliability of the program fMR studies were carried out in 4 healthy individuals (12 contiguous slices, 80 images per slice every 3.1 seconds for a total of 960 images). All the images were transferred to a PC and were processed pixel by pixel within each sequence to obtain an intensity/time curve. The statistical study of the results (Student's test and cross correlation analysis) made it possible to establish the activation of each pixel. The images were prepared using spatial filtering, temporal filtering, baseline correction, normalization and segmentation of the parenchyma. The postprocessing of the results involved the elimination of single pixels, superposition of an anatomical image of greater spatial resolution and anti-aliasing. The application (Xfun 1.0, Valencia, Spain) was developed in Microsoft Visual C++5.0 Developer Studio for Windows NT Workstation. As a representative example, the program took 8.2 seconds to calculate and present the results of the entire study (12 functional maps). In the motor and visual activation experiments, the activation corresponding to regions proximal to the central sulcus of the hemisphere contralateral to the hand that moved and in the occipital cortex were observed. While programs that calculate activation maps are available, the development of software for PCs running Microsoft Windows ensures several key features for its use on a daily basis: it is

  10. The Functional Role of Prion Protein (PrPC on Autophagy

    Directory of Open Access Journals (Sweden)

    Hae-Young Shin

    2013-06-01

    Full Text Available Cellular prion protein (PrPC plays an important role in the cellular defense against oxidative stress. However, the exact protective mechanism of PrPC is unclear. Autophagy is essential for survival, differentiation, development, and homeostasis in several organisms. Although the role that autophagy plays in neurodegenerative disease has yet to be established, it is clear that autophagy-induced cell death is observed in neurodegenerative disorders that exhibit protein aggregations. Moreover, autophagy can promote cell survival and cell death under various conditions. In this review, we describe the involvement of autophagy in prion disease and the effects of PrPC.

  11. Design And Application Of A Pc Interfaced Cosmic Ray Detection System For Secondary School Physics Programs

    CERN Document Server

    Franke, D R

    2005-01-01

    A great deal of current cosmic ray research focuses on those in the ultra high energy regime (>1018 eV). Though interesting in their own right, they also have implications in astronomy and cosmology. The arrival frequency of these particles is on the order of one per square kilometer per century. Such a low number of arrivals requires the construction of detectors that are capable of uninterrupted observation over an area of hundreds of square kilometers. Several detectors already exist, such as AUGER, and AGASA. One proposed detection system involves placing a large number of small detectors in high schools located across large distances. The construction and operation of these detectors is to be part of educational outreach intended to generate interest in physics and science. While this makes labor and finding locations easy, it introduces several new complications such as the training of staff at a pre-college level. Despite being small and robust as compared to their commercial counterparts, these detect...

  12. Localization of the noradrenaline transporter in rat adrenal medulla and PC12 cells: evidence for its association with secretory granules in PC12 cells.

    Science.gov (United States)

    Kippenberger, A G; Palmer, D J; Comer, A M; Lipski, J; Burton, L D; Christie, D L

    1999-09-01

    The noradrenaline transporter (NAT) is present in noradrenergic neurons and a few other specialized cells such as adrenal medullary chromaffin cells and the rat pheochromocytoma (PC12) cell line. We have raised antibodies to a 49-residue segment (NATM2) of the extracellular region (residues 184-232) of bovine NAT. Affinity-purified NATM2 antibodies specifically recognized an 80-kDa band in PC12 cell membranes by western blotting. Bands of a similar size were also detected in membranes from human neuroblastoma (SK-N-SH) cells expressing endogenous NAT and human embryonic kidney (HEK293) cells stably expressing bovine NAT. Immunocytochemistry of rat adrenal tissue showed that NAT staining was colocalized with tyrosine hydroxylase in medullary chromaffin cells. Most NAT immunoreactivity in rat adrenal chromaffin and PC12 cells was present in the cytoplasm and had a punctate appearance. Cell surface biotinylation experiments in PC12 cells confirmed that only a minor fraction of the NAT was present at the cell surface. Subcellular fractionation of PC12 cells showed that relatively little NAT colocalized with plasma membrane, synaptic-like microvesicles, recycling endosomes, or trans-Golgi vesicles. Most of the NAT was associated with [3H]noradrenaline-containing secretory granules. Following nerve growth factor treatment, NAT was localized to the growing tip of neurites. This distribution was similar to the secretory granule marker secretogranin I. We conclude that the majority of NAT is present intracellularly in secretory granules and suggest that NAT may undergo regulated trafficking in PC12 cells.

  13. Sub-ns triplet state formation by non-geminate recombination in PSBTBT:PC 70 BM and PCPDTBT:PC 60 BM organic solar cells

    KAUST Repository

    Etzold, Fabian

    2015-03-02

    The solid-state morphology and photo-generated charge carrier dynamics in low-bandgap polymer:fullerene bulk heterojunction photovoltaic blends using the donor–acceptor type copolymers PCPDTBT or its silicon-substituted analogue PSBTBT as donors are compared by two-dimensional (2D) solid-state nuclear magnetic resonance (NMR) and femto-to microsecond broadband Vis-NIR transient absorption (TA) pump–probe spectroscopy. The 2D solid-state NMR experiments demonstrate that the film morphology of PCPDTBT:PC60BM blends processed with additives such as octanedithiol (ODT) are similar to those of PSBTBT:PC60BM blends in terms of crystallinity, phase segregation, and interfacial contacts. The TA experiments and analysis of the TA data by multivariate curve resolution (MCR) reveal that after exciton dissociation and free charge formation, fast sub-nanosecond non-geminate recombination occurs which leads to a substantial population of the polymer\\'s triplet state. The extent to which triplet states are formed depends on the initial concentration of free charges, which itself is controlled by the microstructure of the blend, especially in case of PCPDTBT:PC60BM. Interestingly, PSBTBT:PC70BM blends show a higher charge generation efficiency, but less triplet state formation at similar free charge carrier concentrations. This indicates that the solid-state morphology and interfacial structures of PSBTBT:PC70BM blends reduces non-geminate recombination, leading to superior device performance compared to optimized PCPDTBT:PC60BM blends.

  14. Transcutaneous Electrical Nerve Stimulation on the PC-5 and PC-6 Points Alleviated Hypotension after Epidural Anaesthesia, Depending on the Stimulus Frequency

    Directory of Open Access Journals (Sweden)

    Young-Chang P. Arai

    2012-01-01

    Full Text Available Neuraxial blockade causes arterial hypotension. Transcutaneous electrical nerve stimulation (TENS at the Neiguan (PC-6 and Jianshi (PC-5 reduces the severity of hypotension after spinal anaesthesia, but did not clarify the optimal stimulus frequency. We hypothesized that the stimulus frequency of TENS at the PC-6 and PC-5 points would influence the severity of hypotension after epidural anaesthesia. 65 ASA I or II male patients presenting for inguinal hernia repair were randomized to five groups: the control group received no treatment; the 2 Hz, 10 Hz, 20 Hz, and 40 Hz groups received TENS at a frequency of 2 Hz, 10 Hz, 20 Hz, and 40 Hz, respectively. The lowest SBP was significantly higher in the 40 Hz group [the control, 84 (74–110 mmHg; the 2 Hz, 96 (62–116 mmHg; the 10 Hz, 100 (68–110 mmHg; the 20 Hz, 96 (64–115 mmHg; the 40 Hz, 104 (75–140 mmHg: P=0.004]. Significantly less patients experienced hypotension in the 40 Hz group [the control, 78%; the 2 Hz, 43%; the 10 Hz, 38%; the 20 Hz, 38%; the 40 Hz, 8%: P=0.008]. TENS on the PC-6 and PC-5 points reduced the severity and incidence of hypotension after epidural anaesthesia, depending on the stimulus frequency.

  15. Structure and Function of Phosphatidylcholine Transfer Protein (PC-TP)/StarD2

    Science.gov (United States)

    Kanno, Keishi; Wu, Michele K.; Scapa, Erez F.; Roderick, Steven L.; Cohen, David E.

    2009-01-01

    Phosphatidylcholine transfer protein (PC-TP) is a highly specific soluble lipid binding protein that transfers phosphatidylcholine between membranes in vitro. PC-TP is a member of the steroidogenic acute regulatory protein–related transfer (START) domain superfamily. Although its biochemical properties and structure are well characterized, the functions of PC-TP in vivo remain incompletely understood. Studies of mice with homozygous disruption of the Pctp gene have largely refuted the hypotheses that this protein participates in the hepatocellular selection and transport of biliary phospholipids, in the production of lung surfactant, in leukotriene biosynthesis and in cellular phosphatidylcholine metabolism. Nevertheless, Pctp−/− mice exhibit interesting defects in lipid homeostasis, the understanding of which should elucidate the biological functions of PC-TP. PMID:17499021

  16. Hijacking PrPC-dependent signal transduction: when prions impair Αβ clearance

    Directory of Open Access Journals (Sweden)

    Julia eHernandez-Rapp

    2014-02-01

    Full Text Available The cellular prion protein PrPC is the normal counterpart of the scrapie prion protein PrPSc, the main component of the infectious agent of Transmissible Spongiform Encephalopathies. The recent discovery that PrPC can serve as a receptor for the amyloid Αβ peptide and relay its neurotoxicity is sparking renewed interest on this protein and its involvement in signal transduction processes. Disease-associated PrPSc shares with Αβ the ability to hijack PrPC-dependent signalling cascades, and thereby instigate pathogenic events. Among these is an impairment of Αβ clearance, uncovered in prion-infected neuronal cells. These findings add another facet to the intricate interplay between PrPC and Αβ. Here, we summarize the connection between PrP-mediated signalling and Αβ clearance and discuss its pathological implications.

  17. Beta.-glucosidase coding sequences and protein from orpinomyces PC-2

    Science.gov (United States)

    Li, Xin-Liang; Ljungdahl, Lars G.; Chen, Huizhong; Ximenes, Eduardo A.

    2001-02-06

    Provided is a novel .beta.-glucosidase from Orpinomyces sp. PC2, nucleotide sequences encoding the mature protein and the precursor protein, and methods for recombinant production of this .beta.-glucosidase.

  18. ALTERATION OF CATECHOLAMINES IN PHOECHROMOCYTOMA (PC12) CELLS IN VITRO BY THE METABOLITES OF CHLOROTRIAZINE HERBICIDE

    Science.gov (United States)

    The effects of four major chlorotriazine metabolites on the constitutive synthesis of the catecholamines dopamine (DA) and norepinephrine (NE) were examined using undifferentiated PC12 cells. NE release and intracellular DA and NE concentrations were quantified following treatme...

  19. Tensile property of thin microcellular PC sheets prepared by compression molding

    Directory of Open Access Journals (Sweden)

    2007-04-01

    Full Text Available Thin microcellular polycarbonate (PC sheets have been prepared by compression molding. Tensile tests were performed on microcellular PC sheets prepared under different conditions, and results show that foaming time plays the main role on the tensile property. The cellular structure prepared in this process has been shown to have a significant effect on the corresponding tensile property of microcellular PC foams. For these foams, Single Blend Model can be used to predict the effect of the relative density on the relative strength, but the experimental data of the tensile modulus is much lower than that predicted by Square-Relationship Model. The effect of cell size on the tensile property of microcellular PC foams was also investigated, and found that the cell size can affect the tensile property, which is different from the result of Kumar. In order to make the tensile property predictable, some mathematical formulas were also simulated.

  20. FTIR analysis on aging characteristics of ABS/PC blend under UV-irradiation in air

    Science.gov (United States)

    Li, Jiarong; Chen, Fu; Yang, Long; Jiang, Long; Dan, Yi

    2017-09-01

    Fourier Transform Infrared Spectroscopy (FTIR) is adopted to study the aging characteristics of poly(acrylonitrile-butadiene-styrene)/polycarbonate (ABS/PC) blend under UV-irradiation in air by analyzing the variation of the three main absorbance at about 967 cm- 1, 1720 cm- 1 and 3420 cm- 1 associated with carbon-hydrogen bonds belonging to 1,4 butadiene, carbonyl and hydroxyl groups, respectively. Results indicate that, under UV-irradiation in air, the photo-oxidation of the blend is not a simple combination of the photo-oxidation of corresponding ABS and PC themselves and takes place predominantly at the ABS component. Due to the interaction between the two components and the Fries rearrangement taken place in the PC component during the UV-irradiation in air, the ABS/PC blends behave higher photo-stability than ABS has.

  1. DIOPS: A PC-Based Wave, Tide and Surf Prediction System

    National Research Council Canada - National Science Library

    Allard, Richard; Dykes, James; Kaihatu, James; Wakeham, Dean

    2005-01-01

    The Distributed Integrated Ocean Prediciton System (DIOPS) is a PC-based wave tide and surf prediction system designed to provide DoD accurate and timely surf predictions for essentially any world-wide location...

  2. Single-event upset in highly scaled commercial silicon-on-insulator PowerPc microprocessors

    Science.gov (United States)

    Irom, Farokh; Farmanesh, Farhad H.

    2004-01-01

    Single event upset effects from heavy ions are measured for Motorola and IBM silicon-on-insulator (SOI) microprocessors with different feature sizes, and core voltages. The results are compared with results for similar devices with build substrates. The cross sections of the SOI processors are lower than their bulk counterparts, but the threshold is about the same, even though the charge collections depth is more than an order of magnitude smaller in the SOI devices. The scaling of the cross section with reduction of feature size and core voltage dependence for SOI microprocessors discussed.

  3. Photocurrent Measurement of PC and PV HgCdTe Detectors

    OpenAIRE

    Eppeldauer, George P.; Martin, Robert J.

    2001-01-01

    Novel preamplifiers for working standard photoconductive (PC) and photovoltaic (PV) HgCdTe detectors have been developed to maintain the spectral responsivity scale of the National Institute of Standards and Technology (NIST) in the wavelength range of 5 ?m to 20 ?m. The linear PC mode preamplifier does not need any compensating source to zero the effect of the detector bias current for the preamplifier output. The impedance multiplication concept with a positive feedback buffer amplifier was...

  4. Pharmacodynamics of TRPV1 Agonists in a Bioassay Using Human PC-3 Cells

    OpenAIRE

    Daniel Alvarez-Berdugo; Marcel Jiménez; Pere Clavé; Laia Rofes

    2014-01-01

    Purpose. TRPV1 is a multimodal channel mainly expressed in sensory neurons. We aimed to explore the pharmacodynamics of the TRPV1 agonists, capsaicin, natural capsaicinoids, and piperine in an in vitro bioassay using human PC-3 cells and to examine desensitization and the effect of the specific antagonist SB366791. Methods. PC-3 cells expressing TRPV1 were incubated with Fluo-4. Fluorescence emission changes following exposition to agonists with and without preincubation with antagonists were...

  5. Use of Topical PC-NSAIDs to Treat Burn Injury and Pain

    Science.gov (United States)

    2016-08-01

    continuity of the spinosum and some areas of stratum basal integrity. This suggests that mitosis, melanin synthesis and transfer and sensory mechanisms...10/21/2015 0.24 calendar months $25,000/yr Evaluation of the chemopreventive activity of Aspirin -PC, using in vitro and in vivo models of...colorectal cancer (CRC) The major goal of this small grant is to evaluate Aspirin -PC for activity against colorectal cancer. Overlap: There is no

  6. Synthesis and characterization of NiPcTSTNa(L) thin films

    Indian Academy of Sciences (India)

    acid tetrasodium salt (NiPcTSTNa) and axial diamine li- gands: ethylenediamine (EDA), 1,4-diaminobutane ... General procedure: A solution of the NiPcTSTNa salt. (C32H12N8Na4NiO12S4) in absolute ethanol was .... tion band, there is no conservation of the electronic momen- tum (Cody 1984). This type of transitions is in ...

  7. Polyethyleneimine-mediated gene delivery into rat pheochromocytoma PC-12 cells.

    Science.gov (United States)

    Lee, Jung Hwa; Ahn, Hyun Hee; Kim, Kyung Sook; Lee, Ju Young; Kim, Moon Suk; Lee, Bong; Khang, Gilson; Lee, Hai Bang

    2008-07-01

    In this study, we examined the use of polyethyleneimine (PEI) as a non-viral gene carrier and lipofectamine(trade mark) 2000 as control for rat pheochromocytoma PC-12 cells. The complex formation of PEI and DNA or lipofectamine and DNA was characterized by gel electrophoresis and measurement of particle size and surface charge. A gradual increase in surface charge (from 0.7 to 43 mV) and a gradual decrease in particle size (from 900 to 130 nm) was observed in the PEI-DNA complex with higher PEI concentrations. The cytotoxicity of PC-12 cells for lipofectamine-DNA complex was similar to PEI-DNA complex at N:P charge ratios of 4 and 8. Transfection efficiency was 14% for lipofectamine and 15% for PEI. At low N:P ratio, DNA condenses poorly, so the particle size tends to be large and polydispersed, resulting in poor transfection efficiency. Meanwhile, a high N:P ratio results in high transfection efficiency and cytotoxicity. Transfected PC-12 cells showed the generation of neurites from transfected PC-12 cells in the presence of NGF, indicating the differentiation of PC-12 cells. NGF-differentiated PC-12 cells were transfected by PEI-DNA complex of N:P charge ratio 8. From real-time imaging for transfection, the enhanced green fluorescent protein (EGFP) started to localize in the nuclei of PC-12 cells at 5 h and localized in the cytoplasm from 15 h. Our study demonstrates that PEI or lipofectamine may be applied as an effective gene carrier for PC-12 cells. 2008 John Wiley & Sons, Ltd

  8. Electro-optical characterization and analysis of CuPc-based solar ...

    Indian Academy of Sciences (India)

    Abstract. Organic solar cells using the CuPc and PTCBI semiconductor layers were studied. A high open circuit voltage of 1.15 V was obtained in a device with ITO/. PEDOT:PSS/CuPc (15 nm)/PTCBI (7 nm)/Al structure. Results were interpreted in terms of a modified CuPc–Al Schottky diode for the thin PTCBI case and a ...

  9. Thin film pc-Si by aluminium induced crystallization on metallic substrate

    Directory of Open Access Journals (Sweden)

    Cayron C.

    2013-04-01

    Full Text Available Thin film polycrystalline silicon (pc-Si on flexible metallic substrates is promising for low cost production of photovoltaic solar cells. One of the attractive methods to produce pc-Si solar cells consists in thickening a large-grained seed layer by epitaxy. In this work, the deposited seed layer is made by aluminium induced crystallization (AIC of an amorphous silicon (a-Si thin film on metallic substrates (Ni/Fe alloy initially coated with a tantalum nitride (TaN conductive diffusion barrier layer. Effect of the thermal budget on the AIC grown pc-Si seed layer was investigated in order to optimize the process (i.e. the quality of the pc-Si thin film. Structural and optical characterizations were carried out using optical microscopy, μ-Raman and Electron Backscatter Diffraction (EBSD. At optimal thermal annealing conditions, the continuous AIC grown pc-Si thin film showed an average grain size around 15 μm. The grains were preferably (001 oriented which is favorable for its epitaxial thickening. This work proves the feasibility of the AIC method to grow large grains pc-Si seed layer on TaN coated metal substrates. These results are, in terms of grains size, the finest obtained by AIC on metallic substrates.

  10. Compartment-Specific Biosensors Reveal a Complementary Subcellular Distribution of Bioactive Furin and PC7

    Directory of Open Access Journals (Sweden)

    Pierpaolo Ginefra

    2018-02-01

    Full Text Available Furin trafficking, and that of related proprotein convertases (PCs, may regulate which substrates are accessible for endoproteolysis, but tools to directly test this hypothesis have been lacking. Here, we develop targeted biosensors that indicate Furin activity in endosomes is 10-fold less inhibited by decanoyl-RVKR-chloromethylketone and enriched >3-fold in endosomes compared to the trans-Golgi network (TGN. Endogenous PC7, which resists this inhibitor, was active in distinct vesicles. Only overexpressed PC7 activity reached the cell surface, endosomes, and the TGN. A PLC motif in the cytosolic tail of PC7 was dispensable for endosomal activity, but it was specifically required for TGN recycling and to rescue proActivin-A cleavage in Furin-depleted B16F1 melanoma cells. In sharp contrast, PC7 complemented Furin in cleaving Notch1 independently of PLC-mediated TGN access. Our study provides a proof in principle that compartment-specific biosensors can be used to gain insight into the regulation of PC trafficking and to map the tropism of PC-specific inhibitors.

  11. The ponderomotive impact of the global seismicity on the magnetospheric Pc1 wave activity

    Science.gov (United States)

    Zotov, Oleg; Guglielmi, Anatol

    2010-05-01

    ULF electromagnetic waves in the magnetosphere are exited due to plasma instabilities. We focus our attention on the Pc1 pearl-type waves in the frequency range of 1 Hz. The observation of Pc1 is a rich source of exciting problems. Specifically, it has been noted that the Pc1 waves correlate with some jerks, that is with the impulsive processes of the celestial and terrestrial origin, for example, with the interplanetary shock fronts, with the magnetospheric injections of particles, with the switching of electric devices, etceteras. The ground based observations testify that sometimes pearls show signs of unexpected relation with the earthquakes. If so, we have the curious difficult problems associated with the interaction between the lithosphere and magnetosphere. The hypothesis of ponderomotive earthquakes impact on the conditions of Pc1 wave propagation predicts an inverse relation between the global seismicity and Pc1 number occurrence. Our report describes the analysis of ground-based long-term observations for checking this prediction. The result of statistical investigation does not contradict our hypothesis. The scenario describing the possible mechanism of relation of the Pc1 waves to earthquakes is presented. The work was supported by grant RFBR 09-05-00048.

  12. Fabrication and Electromagnetic Properties of Conjugated NH2-CuPc@Fe3O4

    Science.gov (United States)

    Yan, Liang; Pu, Zejun; Xu, Mingzhen; Wei, Renbo; Liu, Xiaobo

    2017-10-01

    Conjugated amino-phthalocyanine copper containing carboxyl groups/magnetite (NH2-CuPc@Fe3O4) has been fabricated from FeCl3·6H2O and NH2-CuPc via a simple solvothermal method and its electromagnetic properties investigated. Scanning electron microscopy and transmission electron microscopy revealed that the NH2-CuPc@Fe3O4 was a waxberry-like nanomaterial with NH2-CuPc molecules effectively embedded in the interior of Fe3O4 particles in the form of beads. Introduction of NH2-CuPc effectively improved the complementarity between the dielectric and magnetic losses of the system, resulting in excellent electromagnetic performance. The minimum reflection loss of the as-prepared composite reached -33.4 dB at 7.0 GHz for coating layer thickness of 4.0 mm and bandwidth below -10.0 dB (90% absorption) of up to 3.8 GHz. These results indicate that introduction of NH2-CuPc results in a composite with potential for use as an electromagnetic microwave absorption material.

  13. The Weathering Study of PC/ASA Alloy For Automotive Exterior Applications

    Directory of Open Access Journals (Sweden)

    Sinan Öztürk

    2017-10-01

    Full Text Available Polycarbonates (PC are used in automotive industry due to high physical and mechanical properties like high impact resistance and ductility. Polycarbonates are blended with ABS (Acrylonitrile-Butadiene-Styrene and ASA (Acrylonitrile-Styrene-Acrylate terpolymers for interior and exterior applications of automotive components to achieve good physical and mechanical properties. Other reason for choosing such alloys for interior applications is the IZOD impact resistance requirement higher than 40kJ/m2. Recently, grades of PC/ASA with UV stabilized are developed for non-painted exterior applications. The aim of our study is to investigate whether new developed PC/ASA could be chosen for exterior applications of automotive industry. In this study, the samples are prepared from injection molding and the weathering performance of PC/ASA was tested by a weather-o-meter for 1500h at a total of 1890 kJ/m2 at 340nm with a cut-off filter at λ<290nm. The results are evaluated by FT-IR, DSC, TGA and SEM. It has been observed that UV degradation of PC/ASA leads to several major changes in its IR spectrum like broad bands occurred in the hydroxyl region around 3300 cm-1, and carbonyl stretching region increased around 1728 cm-1. The main degradations were based on photo-oxidation and photo-Fries rearrangement of PC. In our study, the photo-oxidation was followed by the color shift to yellowing of the polymer.

  14. Field-Testing a PC Electronic Documentation System using the Clinical Care Classification© System with Nursing Students

    Directory of Open Access Journals (Sweden)

    Jennifer E. Mannino

    2011-01-01

    Full Text Available Schools of nursing are slow in training their students to keep up with the fast approaching era of electronic healthcare documentation. This paper discusses the importance of nursing documentation, and describes the field-testing of an electronic health record, the Sabacare Clinical Care Classification (CCC© system. The PC-CCC©, designed as a Microsoft Access® application, is an evidence-based electronic documentation system available via free download from the internet. A sample of baccalaureate nursing students from a mid-Atlantic private college used this program to document the nursing care they provided to patients during their sophomore level clinical experience. This paper summarizes the design, training, and evaluation of using the system in practice.

  15. Rotordynamics on the PC: Transient Analysis With ARDS

    Science.gov (United States)

    Fleming, David P.

    1997-01-01

    Personal computers can now do many jobs that formerly required a large mainframe computer. An example is NASA Lewis Research Center's program Analysis of RotorDynamic Systems (ARDS), which uses the component mode synthesis method to analyze the dynamic motion of up to five rotating shafts. As originally written in the early 1980's, this program was considered large for the mainframe computers of the time. ARDS, which was written in Fortran 77, has been successfully ported to a 486 personal computer. Plots appear on the computer monitor via calls programmed for the original CALCOMP plotter; plots can also be output on a standard laser printer. The executable code, which uses the full array sizes of the mainframe version, easily fits on a high-density floppy disk. The program runs under DOS with an extended memory manager. In addition to transient analysis of blade loss, step turns, and base acceleration, with simulation of squeeze-film dampers and rubs, ARDS calculates natural frequencies and unbalance response.

  16. Wind-induced cable vibrations and countermeasures of cables of PC cable-stayed bridge. PC syachokyo keburu no kaze ni yoru shindo to sono taisaku

    Energy Technology Data Exchange (ETDEWEB)

    Yoneda, M. (Kawada Industries Inc., Tokyo (Japan))

    1994-05-01

    In recent years, long span of cable-stayed bridges is remarkable. The wind-induced cable vibration called as line vibration and wake galloping was given as an important problem not only in the steel cable-stayed bridges but also in the PC cable-stayed bridges. The technical engineers in design of the cable-stayed bridges have many times to confront the problems on the vibration control of cables, it is considered that sufficient understand of the wind-induced vibration and countermeasures for cables of the PC cable-stayed bridges is necessary. Many reports on the countermeasure examples and trend of vibration control centred on cables of the cable-stayed bridges have been published. In this paper, the wind-induced vibration of cables in the cable-stayed bridges was reviewed, the examples of countermeasures of vibration control on cables in the PC cable-stayed bridges was mainly introduced. The remaining tasks and future prospects on vibration control of the PC cable-stayed bridges were described. 14 refs., 13 figs., 4 tabs.

  17. Data of the recombination loss mechanisms analysis on Al2O3 PERC cell using PC1D and PC2D simulations

    Directory of Open Access Journals (Sweden)

    Haibing Huang

    2017-04-01

    Full Text Available This data article is related to our recently published article (‘20.8% industrial PERC solar cell: ALD Al2O3 rear surface passivation, efficiency loss mechanisms analysis and roadmap to 24%’, Huang et al., 2017 [1] where we have presented a systematic evaluation of the overall cell processing and a cost-efficient industrial roadmap for PERC cells. Aside from the information already presented in Huang et al., 2017 [1], here we provide data related to Sectin 3 in Huang et al., 2017 [1] concerning the analysis of the recombination losses׳ mechanisms by PC1D V5.9 and PC2D simulations (Clugston and Basore, 1997, Basore and Cabanas-Holmen, 2011, Cabanas-Holmen and Basore, 2012 and Cabanas-Holmen and Basore, 2012. [2–5] on our current industrial Al2O3 PERC cell. The data include: i PC2D simulations on J02, ii the calculation of series resistance and back surface recombination velocity (BSRV on the rear side metallization of PERC cell for the case of a point contact, and iii the PC1D simulation on the cumulative photo-generation and recombination along the distance from the front surface. Finally, the roadmap of the solar cell efficiency for an industrial PERC technology up to 24% is presented, with the aim of providing a potential guideline for industrial researchers.

  18. Optical sensors based on the NiPc-CoPc composite films deposited by drop casting and under the action of centrifugal force

    Science.gov (United States)

    Fatima, Noshin; Ahmed, Muhammad M.; Karimov, Khasan S.; Ahmad, Zubair; Fariq Muhammad, Fahmi

    2017-06-01

    In this study, solution processed composite films of nickel phthalocyanine (NiPc) and cobalt phthalocyanine (CoPc) are deposited by drop casting and under centrifugal force. The films are deposited on surface-type inter-digitated silver electrodes on ceramic alumina substrates. The effects of illumination on the impedance and capacitance of the NiPc-CoPc composite samples are investigated. The samples deposited under centrifugal force show better conductivity than the samples deposited by drop casting technique. In terms of impedance and capacitance sensitivities the samples fabricated under centrifugal force are more sensitive than the drop casting samples. The values of impedance sensitivity ({S}z) are equal to (-1.83) {{M}}{{Ω }}\\cdot {{cm}}2/{mW} and (-5.365){{M}}{{Ω }}\\cdot {{cm}}2/{mW} for the samples fabricated using drop casting and under centrifugal force, respectively. Similarly, the values of capacitance sensitivity ({S}{{c}}) are equal to 0.083 {pF}\\cdot {{cm}}2/{mW} and 0.185 {pF}\\cdot {{cm}}2/{mW} for the samples fabricated by drop casting and under centrifugal force. The films deposited using the different procedures could potentially be viable for different operational modes (i.e., conductive or capacitive) of the optical sensors. Both experimental and simulated results are discussed. Project supported by the Center for Advanced Materials (CAM), Qatar University, Qatar.

  19. Collagenolytic serine protease PC and trypsin PC from king crab Paralithodes camtschaticus: cDNA cloning and primary structure of the enzymes

    Directory of Open Access Journals (Sweden)

    Rebrikov Denis V

    2004-01-01

    Full Text Available Abstract Background In this paper, we describe cDNA cloning of a new anionic trypsin and a collagenolytic serine protease from king crab Paralithodes camtschaticus and the elucidation of their primary structures. Constructing the phylogenetic tree of these enzymes was undertaken in order to prove the evolutionary relationship between them. Results The mature trypsin PC and collagenolytic protease PC contain 237 (Mcalc 24.8 kDa and 226 amino acid residues (Mcalc 23.5 kDa, respectively. Alignments of their amino acid sequences revealed a high degree of the trypsin PC identity to the trypsin from Penaeus vannamei (approximately 70% and of the collagenolytic protease PC identity to the collagenase from fiddler crab Uca pugilator (76%. The phylogenetic tree of these enzymes was constructed. Conclusions Primary structures of the two mature enzymes from P. camtschaticus were obtained and compared with those of other proteolytic proteins, including some enzymes from brachyurans. A phylogenetic analysis was also carried out. These comparisons revealed that brachyurins are closely related to their vertebrate and bacterial congeners, occupy an intermediate position between them, and their study significantly contributes to the understanding of the evolution and function of serine proteases.

  20. Presence of donor-derived thymic epithelial cells in [B6-->MRL/lpr] mice after allogeneic intra-bone marrow-bone marrow transplantation (IBM-BMT).

    Science.gov (United States)

    Takaki, Takashi; Hosaka, Naoki; Miyake, Takashi; Cui, Wenhao; Nishida, Teruhisa; Inaba, Muneo; Ikehara, Susumu

    2008-12-01

    We have previously shown that allogeneic intra-bone marrow-bone marrow transplantation (IBM-BMT) can be used to treat autoimmune diseases in MRL/lpr (H-2(K)) mice with replacing not only hematolymphoid cells but also stromal cells by normal C57BL/6 (B6: H-2(b)) mouse cells. In the present study, we examined for existence of donor-derived thymic epithelial cells (TECs) in the host thymus using green fluorescent protein (GFP)-B6 (H-2(b)) mice. In [GFP-B6-->MRL/lpr] chimeric mice, splenocytes and thymocytes were completely replaced by donor-type cells, and levels of serum autoantibodies and proteinuria were significantly - reduced to those levels of normal donors. Interestingly, GFP-expressing TECs - not only medullary TECs, which express mouse thymus stromal (MTS)-10, but also cortical TECs, which express cytokeratin 18 - were found. Also, the number of autoimmune regulator (AIRE) expressing TECs, which regulates tissue-specific antigens to delete autoreactive cells, was reduced in the chimeric mice to that of the donor, whereas the number of forkhead box N1 (FOXN1) expressing TECs, which are crucial in the terminal differentiation of TECs, remained unchanged. These findings suggest that BMCs contain the precursors of functional TECs, and that they can differentiate into TECs, thereby correcting thymic function.