WorldWideScience

Sample records for program features dramatic

  1. Social insect genomes exhibit dramatic evolution in gene composition and regulation while preserving regulatory features linked to sociality

    DEFF Research Database (Denmark)

    Simola, Daniel F.; Wissler, Lothar; Donahue, Greg

    2013-01-01

    Genomes of eusocial insects code for dramatic examples of phenotypic plasticity and social organization. We compared the genomes of seven ants, the honeybee, and various solitary insects to examine whether eusocial lineages share distinct features of genomic organization. Each ant lineage contain...

  2. Effective Preparation Program Features: A Literature Review

    Science.gov (United States)

    Crow, Gary M.; Whiteman, Rodney S.

    2016-01-01

    This article is a summary of a report prepared for the University Council for Educational Administration Program Improvement Project for the Wallace Foundation. This explores the research base for educational leadership preparation programs, specifically examining literature on program features. The review covers context, candidates, faculty,…

  3. Remodularizing Java programs for comprehension of features

    DEFF Research Database (Denmark)

    Olszak, Andrzej; Jørgensen, Bo Nørregaard

    2009-01-01

    . In absence of these mechanisms, feature implementations tend to be scattered and tangled in terms of object-oriented abstractions, making the code implementing features difficult to locate and comprehend. In this paper we present a semi-automatic method for feature-oriented remodularization of Java programs....... Our method uses execution traces to locate implementations of features, and Java packages to establish explicit feature modules. To evaluate usefulness of the approach, we present a case study where we apply our method to two real-world software systems. The obtained results indicate a significant...

  4. Dramatic School Library Literacy Programs

    Science.gov (United States)

    McPherson, Keith

    2005-01-01

    Many grade K-12 teachers and teacher-librarians know through first-hand experience that drama provides students with very powerful, often nontextual, context in which to build new meanings and avenues for representing and communicating understandings. Similarly, most school districts' language and literacy standards and curriculum reaffirm these…

  5. Institute of Dramatic Art

    Science.gov (United States)

    Schoenmakers, H.

    1976-01-01

    There is a fundamental difference between the courses given at university drama institutes in the Netherlands and those of the drama departments in the American universities. This is one of the points to emerge from this article on the University of Amsterdam's Institute of Dramatic Art written by a senior staff member of that institute.…

  6. Lord Byron's dramatic work

    Directory of Open Access Journals (Sweden)

    Andrejević Ana

    2009-01-01

    Full Text Available All of Byron's six finished dramas aspire to display conflict between the individual will and the strength of the universal and omnipresent inevitability. Although he accentuated classical dramatic rules or three dramatic unities as the way to construct a good drama, he couldn't escape from the deep rooted romantic feeling of his genius. His plays are thus pictures of existing existential revolt with the protagonists true to their feelings, always consistent, active and devoted to one general idea. They are estranged from the meaningless world that leads them to rebellion and death, but prometheously constructed are the most successful and memorable element of his plays. Byron as a dramatist always tries to find an everlasting dimension and virtue in the meaningless world through the construction of personal myth and thus the main subject of all his dramas is freedom in all its aspects.

  7. Feature extraction from multiple data sources using genetic programming.

    Energy Technology Data Exchange (ETDEWEB)

    Szymanski, J. J. (John J.); Brumby, Steven P.; Pope, P. A. (Paul A.); Eads, D. R. (Damian R.); Galassi, M. C. (Mark C.); Harvey, N. R. (Neal R.); Perkins, S. J. (Simon J.); Porter, R. B. (Reid B.); Theiler, J. P. (James P.); Young, A. C. (Aaron Cody); Bloch, J. J. (Jeffrey J.); David, N. A. (Nancy A.); Esch-Mosher, D. M. (Diana M.)

    2002-01-01

    Feature extration from imagery is an important and long-standing problem in remote sensing. In this paper, we report on work using genetic programming to perform feature extraction simultaneously from multispectral and digital elevation model (DEM) data. The tool used is the GENetic Imagery Exploitation (GENIE) software, which produces image-processing software that inherently combines spatial and spectral processing. GENIE is particularly useful in exploratory studies of imagery, such as one often does in combining data from multiple sources. The user trains the software by painting the feature of interest with a simple graphical user interface. GENIE then uses genetic programming techniques to produce an image-processing pipeline. Here, we demonstrate evolution of image processing algorithms that extract a range of land-cover features including towns, grasslands, wild fire burn scars, and several types of forest. We use imagery from the DOE/NNSA Multispectral Thermal Imager (MTI) spacecraft, fused with USGS 1:24000 scale DEM data.

  8. Feature Scaling via Second-Order Cone Programming

    Directory of Open Access Journals (Sweden)

    Zhizheng Liang

    2016-01-01

    Full Text Available Feature scaling has attracted considerable attention during the past several decades because of its important role in feature selection. In this paper, a novel algorithm for learning scaling factors of features is proposed. It first assigns a nonnegative scaling factor to each feature of data and then adopts a generalized performance measure to learn the optimal scaling factors. It is of interest to note that the proposed model can be transformed into a convex optimization problem: second-order cone programming (SOCP. Thus the scaling factors of features in our method are globally optimal in some sense. Several experiments on simulated data, UCI data sets, and the gene data set are conducted to demonstrate that the proposed method is more effective than previous methods.

  9. Alaska Program Point and Line Feature GIS Data from COMIDA, ANIMIDA and cANIMIDA Programs

    Data.gov (United States)

    Bureau of Ocean Energy Management, Department of the Interior — Alaska Program Map Service contains point and line features from the following BOEM Alaska Region environmental monitoring programs: Chukchi Sea Offshore Monitoring...

  10. Aura: A Multi-Featured Programming Framework in Python

    Directory of Open Access Journals (Sweden)

    2010-09-01

    Full Text Available This paper puts forward the design, programming and application of innovative educational software, ‘Aura’ made using Python and PyQt Python bindings. The research paper presents a new concept of using a single tool to relate between syntaxes of various programming languages and algorithms. It radically increases their understanding and retaining capacity, since they can correlate between many programming languages. The software is a totally unorthodox attempt towards helping students who have their first tryst with programming languages. The application is designed to help students understand how algorithms work and thus, help them in learning multiple programming languages on a single platform using an interactive graphical user interface. This paper elucidates how using Python and PyQt bindings, a comprehensive feature rich application, that implements an interactive algorithm building technique, a web browser, multiple programming language framework, a code generator and a real time code sharing hub be embedded into a single interface. And also explains, that using Python as building tool, it requires much less coding than conventional feature rich applications coded in other programming languages, and at the same time does not compromise on stability, inter-operability and robustness of the application.

  11. Mall Walking Program Environments, Features, and Participants: A Scoping Review.

    Science.gov (United States)

    Farren, Laura; Belza, Basia; Allen, Peg; Brolliar, Sarah; Brown, David R; Cormier, Marc L; Janicek, Sarah; Jones, Dina L; King, Diane K; Marquez, David X; Rosenberg, Dori E

    2015-08-13

    Walking is a preferred and recommended physical activity for middle-aged and older adults, but many barriers exist, including concerns about safety (ie, personal security), falling, and inclement weather. Mall walking programs may overcome these barriers. The purpose of this study was to summarize the evidence on the health-related value of mall walking and mall walking programs. We conducted a scoping review of the literature to determine the features, environments, and benefits of mall walking programs using the RE-AIM framework (reach, effectiveness, adoption, implementation, and maintenance). The inclusion criteria were articles that involved adults aged 45 years or older who walked in indoor or outdoor shopping malls. Exclusion criteria were articles that used malls as laboratory settings or focused on the mechanics of walking. We included published research studies, dissertations, theses, conference abstracts, syntheses, nonresearch articles, theoretical papers, editorials, reports, policy briefs, standards and guidelines, and nonresearch conference abstracts and proposals. Websites and articles written in a language other than English were excluded. We located 254 articles on mall walking; 32 articles met our inclusion criteria. We found that malls provided safe, accessible, and affordable exercise environments for middle-aged and older adults. Programmatic features such as program leaders, blood pressure checks, and warm-up exercises facilitated participation. Individual benefits of mall walking programs included improvements in physical, social, and emotional well-being. Limited transportation to the mall was a barrier to participation. We found the potential for mall walking programs to be implemented in various communities as a health promotion measure. However, the research on mall walking programs is limited and has weak study designs. More rigorous research is needed to define best practices for mall walking programs' reach, effectiveness, adoption

  12. Genetic programming approach to extracting features from remotely sensed imagery

    Energy Technology Data Exchange (ETDEWEB)

    Theiler, J. P. (James P.); Perkins, S. J. (Simon J.); Harvey, N. R. (Neal R.); Szymanski, J. J. (John J.); Brumby, Steven P.

    2001-01-01

    Multi-instrument data sets present an interesting challenge to feature extraction algorithm developers. Beyond the immediate problems of spatial co-registration, the remote sensing scientist must explore a complex algorithm space in which both spatial and spectral signatures may be required to identify a feature of interest. We describe a genetic programming/supervised classifier software system, called Genie, which evolves and combines spatio-spectral image processing tools for remotely sensed imagery. We describe our representation of candidate image processing pipelines, and discuss our set of primitive image operators. Our primary application has been in the field of geospatial feature extraction, including wildfire scars and general land-cover classes, using publicly available multi-spectral imagery (MSI) and hyper-spectral imagery (HSI). Here, we demonstrate our system on Landsat 7 Enhanced Thematic Mapper (ETM+) MSI. We exhibit an evolved pipeline, and discuss its operation and performance.

  13. Mall Walking Program Environments, Features, and Participants: A Scoping Review

    Science.gov (United States)

    Belza, Basia; Allen, Peg; Brolliar, Sarah; Brown, David R.; Cormier, Marc L.; Janicek, Sarah; Jones, Dina L.; King, Diane K.; Marquez, David X.; Rosenberg, Dori E.

    2015-01-01

    Introduction Walking is a preferred and recommended physical activity for middle-aged and older adults, but many barriers exist, including concerns about safety (ie, personal security), falling, and inclement weather. Mall walking programs may overcome these barriers. The purpose of this study was to summarize the evidence on the health-related value of mall walking and mall walking programs. Methods We conducted a scoping review of the literature to determine the features, environments, and benefits of mall walking programs using the RE-AIM framework (reach, effectiveness, adoption, implementation, and maintenance). The inclusion criteria were articles that involved adults aged 45 years or older who walked in indoor or outdoor shopping malls. Exclusion criteria were articles that used malls as laboratory settings or focused on the mechanics of walking. We included published research studies, dissertations, theses, conference abstracts, syntheses, nonresearch articles, theoretical papers, editorials, reports, policy briefs, standards and guidelines, and nonresearch conference abstracts and proposals. Websites and articles written in a language other than English were excluded. Results We located 254 articles on mall walking; 32 articles met our inclusion criteria. We found that malls provided safe, accessible, and affordable exercise environments for middle-aged and older adults. Programmatic features such as program leaders, blood pressure checks, and warm-up exercises facilitated participation. Individual benefits of mall walking programs included improvements in physical, social, and emotional well-being. Limited transportation to the mall was a barrier to participation. Conclusion We found the potential for mall walking programs to be implemented in various communities as a health promotion measure. However, the research on mall walking programs is limited and has weak study designs. More rigorous research is needed to define best practices for mall walking

  14. Dramatic Presence in Improvised Stories

    NARCIS (Netherlands)

    Swartjes, I.M.T.; Theune, Mariet

    2009-01-01

    We investigate how to achieve a sense of dramatic presence (the perception of being “in” a story, playing the role of one of its characters), with the aim of building systems that can offer the same. Improvisational theatre might serve as a model for this experience, where there is no guiding plot;

  15. Little Eyolf and dramatic tradition

    Directory of Open Access Journals (Sweden)

    Roland Lysell

    2015-02-01

    Full Text Available The article criticises an Ibsen tradition who has seen the last scene of Little Eyolf as a reconciliation. Instead, the article discusses the improbability of a happy marriage characterised by social engagement. The play is open but it is hardly probable that Rita, with her erotic desire, and Allmers, whose desire has turned into metaphysics, can be happy together. The arguments refer to inner criteria and the constantly present dramatic tradition.

  16. Particular features of development and realizations of purposeful complex programs in Ukraine

    Directory of Open Access Journals (Sweden)

    О.В. Самков

    2004-04-01

    Full Text Available  Features of development and realization of aviation purposeful complex programs in Ukraine are examined. The necessity of metrology securing of aviation programs as well as decision making process in the logistics system during complex programs development and realization. Examples from the modernization programs of aviation are analyzed.

  17. Feature Program: Project N.I.C.E.

    Science.gov (United States)

    Education Journal of the Institute for the Development of Indian Law, 1973

    1973-01-01

    The Northern Indian California Education Project, established in 1971, has pilot programs in 6 schools which reach out to 24 additional schools. The article lists project goals, the implementation of these goals, accomplishments, and available materials. (KM)

  18. Remodularizing Java Programs for Improved Locality of Feature Implementations in Source Code

    DEFF Research Database (Denmark)

    Olszak, Andrzej; Jørgensen, Bo Nørregaard

    2011-01-01

    Explicit traceability between features and source code is known to help programmers to understand and modify programs during maintenance tasks. However, the complex relations between features and their implementations are not evident from the source code of object-oriented Java programs. Conseque...

  19. Features of using multimedia technologies at lecturing programming

    Directory of Open Access Journals (Sweden)

    G. S. Ivanova

    2014-01-01

    Full Text Available The subject of study of this paper is multimedia capabilities, which are used for lectures on programming for undergraduate students to learn Computer Science and Engineering.The objective is to analyze the factors affecting the efficiency of lectures on programming, readable using multimedia, identifying the advantages and disadvantages of using presentations and process of creating and debugging programs in software environments demonstration, and to make recommendations on the use of illustrative material aimed at improving student's handout with the knowledge readable material.Scientific novelty of the material is to identify and analyze the factors influencing the effectiveness of teaching programming using multimedia as well as to make recommendations on the creation of illustrative material in the form of lecture presentations, analyse the negative side effects of presentations and opportunities to address them.It is stated that even at the initial stage of teaching in programming the amount of learning material and associated details in their records to which student's attention should be drawn, commensurate with the restrictions of psycho physiological capabilities defined for modern undergraduate students to remember and learn. The conclusion about expediency to improve lectures efficiency through the use of multimedia equipment capabilities is made.The types of illustrative material used in lectures on programming are listed and named, examples of illustrative material for presentation slides are analyzed. The positive results of the process of program creating, debugging and running directly in the programming environment during the lecture are underlined .As the merits of the multimedia-based lectures are marked a significant reduction of time to be required for material presentation ( from 10 to 30 % and the structured and with no errors in the program texts of lectures available for students. Negative effects of the multimedia

  20. Articulation Therapy Using Distinctive Feature Analysis to Structure the Training Program: Two Case Studies.

    Science.gov (United States)

    Ruder, Kenneth F.; Bunce, Betty H.

    1981-01-01

    Two case reports of 4 and 5 year old children describe the rationale and procedures for structuring an articulation therapy program on the basis of distinctive feature analysis of the child's articulation problems. (Author/DB)

  1. Diffusion of Courses with World Wide Web Features: Perceptions of Journalism and Mass Communication Program Administrators.

    Science.gov (United States)

    Sutherland, Patrick J.

    2003-01-01

    Examines perceptions of top administrators concerning courses with Web features at Association of Schools of Journalism and Mass Communication (ASJMC) programs. Studies the imperatives and pressures to implement courses with Web features as well as resistances to implementation. Suggests that administrators perceive an extensive set of needs and…

  2. Features of circular training as a part of strength training program for dancer

    OpenAIRE

    Олександрова [Veronika Aleksandrova], Вероніка Анатоліївна; Шиян [Vladimir Shiyan], Віктор Володимирович

    2013-01-01

    says about the results of the experimental program which has been worked out and theoretically substantiated. The program includes two ways of strength training which are strength and stamina development. The program consists of three weeklong micro cycles (units): first week – drawing unit, second week – strength unit, third week – stamina development unit. Circular trainings were carried out according to individual differences of the dancers. The analysis of the literature about features of...

  3. Successful Bullying Prevention Programs: Influence of Research Design, Implementation Features, and Program Components

    Directory of Open Access Journals (Sweden)

    Bryanna Hahn Fox

    2012-12-01

    Full Text Available Bullying prevention programs have been shown to be generally effective in reducing bullying and victimization. However, the effects are relatively small in randomized experiments and greater in quasi-experimental and age-cohort designs. Programs that are more intensive and of longer duration (for both children and teachers are more effective, as are programs containing more components. Several program components are associated with large effect sizes, including parent training or meetings and teacher training. These results should inform the design and evaluation of anti-bullying programs in the future, and a system ofaccreditation of effective programs.

  4. Using Hierarchical Latent Dirichlet Allocation to Construct Feature Tree for Program Comprehension

    Directory of Open Access Journals (Sweden)

    Xiaobing Sun

    2017-01-01

    Full Text Available Program comprehension is an important task faced by developers during software maintenance. With the increasing complexity of evolving systems, program comprehension becomes more and more difficult. In practice, programmers are accustomed to getting a general view of the features in a software system and then finding the interesting or necessary files to start the understanding process. Given a system, developers may need a general view of the system. The traditional view of a system is shown in a package-class structure which is difficult to understand, especially for large systems. In this article, we focus on understanding the system in both feature view and file structure view. This article proposes an approach to generate a feature tree based on hierarchical Latent Dirichlet Allocation (hLDA, which includes two hierarchies, the feature hierarchy and file structure hierarchy. The feature hierarchy shows the features from abstract level to detailed level, while the file structure hierarchy shows the classes from whole to part. Empirical results show that the feature tree can produce a view for the features and files, and the clustering of classes in the package in our approach is better (in terms of recall than the other clustering approach, that is, hierarchical clustering.

  5. Introducing Dramatic Inquiry as Visual Art Education

    Science.gov (United States)

    Rhoades, Mindi; Daiello, Vittoria S.

    2016-01-01

    This article defines dramatic inquiry, exploring its possible contributions to discourses on subjectivity, embodied pedagogy, and relational knowing in art education. As a communal, ensemble endeavor emerging from the discipline of drama education, dramatic inquiry offers strategies for enhancing arts education's critical inquiries by facilitating…

  6. Combining heterogeneous features for colonic polyp detection in CTC based on semi-definite programming

    Science.gov (United States)

    Wang, Shijun; Yao, Jianhua; Petrick, Nicholas A.; Summers, Ronald M.

    2009-02-01

    Colon cancer is the second leading cause of cancer-related deaths in the United States. Computed tomographic colonography (CTC) combined with a computer aided detection system provides a feasible combination for improving colonic polyps detection and increasing the use of CTC for colon cancer screening. To distinguish true polyps from false positives, various features extracted from polyp candidates have been proposed. Most of these features try to capture the shape information of polyp candidates or neighborhood knowledge about the surrounding structures (fold, colon wall, etc.). In this paper, we propose a new set of shape descriptors for polyp candidates based on statistical curvature information. These features, called histogram of curvature features, are rotation, translation and scale invariant and can be treated as complementing our existing feature set. Then in order to make full use of the traditional features (defined as group A) and the new features (group B) which are highly heterogeneous, we employed a multiple kernel learning method based on semi-definite programming to identify an optimized classification kernel based on the combined set of features. We did leave-one-patient-out test on a CTC dataset which contained scans from 50 patients (with 90 6-9mm polyp detections). Experimental results show that a support vector machine (SVM) based on the combined feature set and the semi-definite optimization kernel achieved higher FROC performance compared to SVMs using the two groups of features separately. At a false positive per patient rate of 7, the sensitivity on 6-9mm polyps using the combined features improved from 0.78 (Group A) and 0.73 (Group B) to 0.82 (p<=0.01).

  7. Multi-Objective Genetic Programming with Redundancy-Regulations for Automatic Construction of Image Feature Extractors

    Science.gov (United States)

    Watchareeruetai, Ukrit; Matsumoto, Tetsuya; Takeuchi, Yoshinori; Kudo, Hiroaki; Ohnishi, Noboru

    We propose a new multi-objective genetic programming (MOGP) for automatic construction of image feature extraction programs (FEPs). The proposed method was originated from a well known multi-objective evolutionary algorithm (MOEA), i.e., NSGA-II. The key differences are that redundancy-regulation mechanisms are applied in three main processes of the MOGP, i.e., population truncation, sampling, and offspring generation, to improve population diversity as well as convergence rate. Experimental results indicate that the proposed MOGP-based FEP construction system outperforms the two conventional MOEAs (i.e., NSGA-II and SPEA2) for a test problem. Moreover, we compared the programs constructed by the proposed MOGP with four human-designed object recognition programs. The results show that the constructed programs are better than two human-designed methods and are comparable with the other two human-designed methods for the test problem.

  8. Creative Dramatics: An Outlet for Mental Handicaps

    Science.gov (United States)

    Blumberg, Marvin L.

    1976-01-01

    The United Cerebral Palsy of Queens Center conducted a creative dramatics workshop for mental handicaps. Main objectives of the workshop were personality development and social improvement toward better job potential in the outside employment situation. (TA)

  9. Spermatogenesis-specific features of the meiotic program in Caenorhabditis elegans.

    Directory of Open Access Journals (Sweden)

    Diane C Shakes

    2009-08-01

    Full Text Available In most sexually reproducing organisms, the fundamental process of meiosis is implemented concurrently with two differentiation programs that occur at different rates and generate distinct cell types, sperm and oocytes. However, little is known about how the meiotic program is influenced by such contrasting developmental programs. Here we present a detailed timeline of late meiotic prophase during spermatogenesis in Caenorhabditis elegans using cytological and molecular landmarks to interrelate changes in chromosome dynamics with germ cell cellularization, spindle formation, and cell cycle transitions. This analysis expands our understanding C. elegans spermatogenesis, as it identifies multiple spermatogenesis-specific features of the meiotic program and provides a framework for comparative studies. Post-pachytene chromatin of spermatocytes is distinct from that of oocytes in both composition and morphology. Strikingly, C. elegans spermatogenesis includes a previously undescribed karyosome stage, a common but poorly understood feature of meiosis in many organisms. We find that karyosome formation, in which chromosomes form a constricted mass within an intact nuclear envelope, follows desynapsis, involves a global down-regulation of transcription, and may support the sequential activation of multiple kinases that prepare spermatocytes for meiotic divisions. In spermatocytes, the presence of centrioles alters both the relative timing of meiotic spindle assembly and its ultimate structure. These microtubule differences are accompanied by differences in kinetochores, which connect microtubules to chromosomes. The sperm-specific features of meiosis revealed here illuminate how the underlying molecular machinery required for meiosis is differentially regulated in each sex.

  10. A Multiobjective Genetic Programming-Based Ensemble for Simultaneous Feature Selection and Classification.

    Science.gov (United States)

    Nag, Kaustuv; Pal, Nikhil R

    2016-02-01

    We present an integrated algorithm for simultaneous feature selection (FS) and designing of diverse classifiers using a steady state multiobjective genetic programming (GP), which minimizes three objectives: 1) false positives (FPs); 2) false negatives (FNs); and 3) the number of leaf nodes in the tree. Our method divides a c -class problem into c binary classification problems. It evolves c sets of genetic programs to create c ensembles. During mutation operation, our method exploits the fitness as well as unfitness of features, which dynamically change with generations with a view to using a set of highly relevant features with low redundancy. The classifiers of i th class determine the net belongingness of an unknown data point to the i th class using a weighted voting scheme, which makes use of the FP and FN mistakes made on the training data. We test our method on eight microarray and 11 text data sets with diverse number of classes (from 2 to 44), large number of features (from 2000 to 49 151), and high feature-to-sample ratio (from 1.03 to 273.1). We compare our method with a bi-objective GP scheme that does not use any FS and rule size reduction strategy. It depicts the effectiveness of the proposed FS and rule size reduction schemes. Furthermore, we compare our method with four classification methods in conjunction with six features selection algorithms and full feature set. Our scheme performs the best for 380 out of 474 combinations of data sets, algorithm and FS method.

  11. The features of teaching methods of programming in the system of supplementary education in informatics and ICT

    National Research Council Canada - National Science Library

    Наталья Геннадьевна Саблукова

    2010-01-01

    The model of formation of the rational contents of teaching to programming in described in the article in view of specificity of supplementary education and features of visual surroundings of programming...

  12. Epileptic MEG Spike Detection Using Statistical Features and Genetic Programming with KNN.

    Science.gov (United States)

    Alotaiby, Turky N; Alrshoud, Saud R; Alshebeili, Saleh A; Alhumaid, Majed H; Alsabhan, Waleed M

    2017-01-01

    Epilepsy is a neurological disorder that affects millions of people worldwide. Monitoring the brain activities and identifying the seizure source which starts with spike detection are important steps for epilepsy treatment. Magnetoencephalography (MEG) is an emerging epileptic diagnostic tool with high-density sensors; this makes manual analysis a challenging task due to the vast amount of MEG data. This paper explores the use of eight statistical features and genetic programing (GP) with the K-nearest neighbor (KNN) for interictal spike detection. The proposed method is comprised of three stages: preprocessing, genetic programming-based feature generation, and classification. The effectiveness of the proposed approach has been evaluated using real MEG data obtained from 28 epileptic patients. It has achieved a 91.75% average sensitivity and 92.99% average specificity.

  13. Epileptic MEG Spike Detection Using Statistical Features and Genetic Programming with KNN

    Directory of Open Access Journals (Sweden)

    Turky N. Alotaiby

    2017-01-01

    Full Text Available Epilepsy is a neurological disorder that affects millions of people worldwide. Monitoring the brain activities and identifying the seizure source which starts with spike detection are important steps for epilepsy treatment. Magnetoencephalography (MEG is an emerging epileptic diagnostic tool with high-density sensors; this makes manual analysis a challenging task due to the vast amount of MEG data. This paper explores the use of eight statistical features and genetic programing (GP with the K-nearest neighbor (KNN for interictal spike detection. The proposed method is comprised of three stages: preprocessing, genetic programming-based feature generation, and classification. The effectiveness of the proposed approach has been evaluated using real MEG data obtained from 28 epileptic patients. It has achieved a 91.75% average sensitivity and 92.99% average specificity.

  14. Hospitality Ethical Growth via Dramatic English

    Directory of Open Access Journals (Sweden)

    Cherif Haberih

    2014-09-01

    Full Text Available The objective of this research is to find scalable data and statistics for realistic rendering of Ethical and Dramatic English gradual growth based on Thai students within the Hospitality and Tourism Industry. We also intend to prove that Dramatic English serves English improvements for Thai students. Furthermore we intend to better understand students' behaviors and ethical growth processes based on cultural, social, personal and psychological background through Dramatic English for Hospitality Industry. Universities and Educational Organizations today are involved in complex tasks. With the burst of communication through Medias and an ever increasing student’s demand for higher quality education and services, having a competitive advantage is seen as a necessary tool. Education has evolved and its business approach requires a modern and inadequate solution. As of today, Thailand is in need of a new generation of tools applied to modernize the current educational system, and emphasize on new methods.

  15. Narrative and Dramatic Structure in Plato's Dialogues

    Directory of Open Access Journals (Sweden)

    M Pourelm

    2013-02-01

    Full Text Available Plato did not allow many artists and poets into his Utopia Republic because of their bad and misleading influence on the young. But it seems that he learned storytelling and narrating from them and concealed what he learned beneath his philosophy. Thus, Plato's dialogues became more effective and gained aesthetic and artistic qualities. Theaetetus, one of the best known dialogues of Plato, is a conversation and discussion about episteme. Due to using classical dramatic structure, this dialogue is the most important dialogue with regard to dramatization of philosophical thoughts. The goal of this article is to study the dramatic structure of Plato's dialogues and show its potentials for interaction with narrative theories. It could be said that Plato's dialogues have many resemblances to the Greek drama and, today, we can call Plato a playwright. Thus, it is important and necessary to reread and reevaluate Plato's works via narratological view.

  16. DRAMATIC LITERATURE FOR DEVELOPMENT: IMPERATIVES OF ...

    African Journals Online (AJOL)

    Precious

    though a fictitious work, is born out of the creative writers concept of a society that he has observed and mapped out creative devices upon which he/ she intends to comment on that social issue which traumatizes the populace; hence no arguing the point that dramatic literature resides in the worldview of the dramatist who.

  17. Nietzsche contra Burke: The Melodrama in Dramatism.

    Science.gov (United States)

    Desilet, Gregory

    1989-01-01

    Examines Kenneth Burke's and Friedrich Nietzsche's similar understanding of the hortatory nature of language-using, weighed against their radically differing conceptions of the negative, which allows a distinction between two genres of dramatism, and illustrates contrasting orientations toward symbolic activity in general. (SR)

  18. The Trial of Latin Language: A Dramatization.

    Science.gov (United States)

    Handwright, Florence B.

    An allegorical scenario in which five witnesses (English Language, Christian Religion, Science, Music, and Modern Society) dramatize the charge of irrelevance which Modern Society makes against Latin Language. After hearing the charges of the prosecution and the defense state its case, a verdict which recognizes the impact of the legacy of Rome is…

  19. Back to Basics through Creative Dramatics.

    Science.gov (United States)

    Rubin, Janet E.

    In the back to basics era, creative dramatics should still be used in the English classroom because it helps to develop the entire child. For some time, teaching strategies have been directed at the left brain, the hemisphere that deals with logical and linear functions. Recently, however, attention has been given to the right side of the brain,…

  20. Dramatic literature, digitisation and cultural mediatisation: a ...

    African Journals Online (AJOL)

    ... impact of digital technology on the African literature from the literary, legal, pedagogical, socio-cultural and moral perspectives. The future of creativity and the possible emergence of new canons for critiquing the new media are considered. Keywords: New Media, Digitisation, Dramatic Literature, Postmodernism Criticism ...

  1. Exploration of Genetic Programming Optimal Parameters for Feature Extraction from Remote Sensed Imagery

    Science.gov (United States)

    Gao, P.; Shetty, S.; Momm, H. G.

    2014-11-01

    Evolutionary computation is used for improved information extraction from high-resolution satellite imagery. The utilization of evolutionary computation is based on stochastic selection of input parameters often defined in a trial-and-error approach. However, exploration of optimal input parameters can yield improved candidate solutions while requiring reduced computation resources. In this study, the design and implementation of a system that investigates the optimal input parameters was researched in the problem of feature extraction from remotely sensed imagery. The two primary assessment criteria were the highest fitness value and the overall computational time. The parameters explored include the population size and the percentage and order of mutation and crossover. The proposed system has two major subsystems; (i) data preparation: the generation of random candidate solutions; and (ii) data processing: evolutionary process based on genetic programming, which is used to spectrally distinguish the features of interest from the remaining image background of remote sensed imagery. The results demonstrate that the optimal generation number is around 1500, the optimal percentage of mutation and crossover ranges from 35% to 40% and 5% to 0%, respectively. Based on our findings the sequence that yielded better results was mutation over crossover. These findings are conducive to improving the efficacy of utilizing genetic programming for feature extraction from remotely sensed imagery.

  2. Residential immersive life skills programs for youth with disabilities: service providers' perceptions of experiential benefits and key program features.

    Science.gov (United States)

    King, Gillian; McPherson, Amy; Kingsnorth, Shauna; Stewart, Debra; Glencross-Eimantas, Tanya; Gorter, Jan Willem; Jones-Galley, Kimberlea; Morrison, Andrea; Isihi, Ana Maria

    2015-01-01

    The objective was to determine service providers' perceptions of the experiential benefits of residential immersive life skills (RILS) programs for youth with disabilities, along with important program features. Thirty-seven service providers from three RILS programs took part in qualitative interviews. Themes were derived using a phenomenological approach. There were perceived benefits for youth, and also for parents and service providers. Study themes concerned the process of youth empowerment, life-changing experiences for youth and parents, and changed service provider views affecting practice. Youth changes were attributed to the residential group format and afforded opportunities, which included being away from home, navigating public transportation, directing attendant services, and sharing intense learning and social experiences with peers. Youth were seen to experience important personal changes in life skills, self-confidence, self-understandings, and self-advocacy. Perceived benefits for parents included realizations concerning their child's abilities and new hope for the future. Service providers indicated changes in their knowledge, perspectives, and approach to practice. The findings suggest that life skills programs should be intentionally designed to provide challenging experiential opportunities that motivate youth to engage in new life directions by providing new insights, self-realizations, and positive yet realistic views of the future. Service providers indicated the importance of challenging, real-world experiential opportunities that provide youth with disabilities with new insights, self-realizations, and positive yet realistic views of the future. Important experiential opportunities for youth included being away from home, navigating public transportation, directing attendant care, and sharing intense learning and social experiences with peers. The findings provide preliminary qualitative evidence that life skills programs should be

  3. Care initiation area yields dramatic results.

    Science.gov (United States)

    2009-03-01

    The ED at Gaston Memorial Hospital in Gastonia, NC, has achieved dramatic results in key department metrics with a Care Initiation Area (CIA) and a physician in triage. Here's how the ED arrived at this winning solution: Leadership was trained in and implemented the Kaizen method, which eliminates redundant or inefficient process steps. Simulation software helped determine additional space needed by analyzing arrival patterns and other key data. After only two days of meetings, new ideas were implemented and tested.

  4. Dramatic Response of Nail Psoriasis to Infliximab

    Directory of Open Access Journals (Sweden)

    Gilles Safa

    2011-01-01

    Full Text Available Nail psoriasis, affecting up to 50% of psoriatic patients, is an important cause of serious psychological and physical distress. Traditional treatments for nail psoriasis, which include topical or intralesional corticosteroids, topical vitamin D analogues, photochemotherapy, oral retinoids, methotrexate, and cyclosporin, can be time-consuming, painful, or limited by significant toxicities. Biological agents may have the potential to revolutionize the management of patients with disabling nail psoriasis. We present another case of disabling nail psoriasis that responded dramatically to infliximab.

  5. The features of teaching methods of programming in the system of supplementary education in informatics and ICT

    Directory of Open Access Journals (Sweden)

    Наталья Геннадьевна Саблукова

    2010-06-01

    Full Text Available The model of formation of the rational contents of teaching to programming in described in the article in view of specificity of supplementary education and features of visual surroundings of programming. The realization of structure of the contents of training to programming is written stage by stage.

  6. Mission X in Japan, an Education Outreach Program Featuring Astronautical Specialties and Knowledge

    Science.gov (United States)

    Niihori, Maki; Yamada, Shin; Matsuo, Tomoaki; Nakao, Reiko; Nakazawa, Takashi; Kamiyama, Yoshito; Takeoka, Hajime; Matsumoto, Akiko; Ohshima, Hiroshi; Mukai, Chiaki

    In the science field, disseminating new information to the public is becoming increasingly important, since it can aid a deeper understanding of scientific significance and increase the number of future scientists. As part of our activities, we at the Japan Aerospace Exploration Agency (JAXA) Space Biomedical Research Office, started work to focus on education outreach featuring space biomedical research. In 2010, we launched the Mission X education program in Japan, named after “Mission X: Train Like an Astronaut” (hereinafter called “Mission X”), mainly led by NASA and European Space Agency (ESA). Mission X is an international public outreach program designed to encourage proper nutrition and exercise and teaching young people to live and eat like astronauts. We adopted Mission X's standpoint, and modified the program based on the originals to suit Japanese culture and the students' grade. Using astronauts as examples, this mission can motivate and educate students to instill and adopt good nutrition and physical fitness as life-long practices.Here we introduce our pilot mission of the “Mission X in Japan” education program, which was held in early 2011. We are continuing the education/public outreach to promote the public understanding of science and contribute to science education through lectures on astronautical specialties and knowledge.

  7. New features of the National Cholesterol Education Program Adult Treatment Panel III lipid-lowering guidelines.

    Science.gov (United States)

    Brewer, H Bryan

    2003-04-01

    The National Cholesterol Education Program (NCEP) Adult Treatment Panel III (ATP III) guidelines for lipid-lowering therapy to reduce coronary heart disease (CHD) risk contain a number of features that distinguish them from the previous ATP guidelines. These new features include modifications in lipid/lipoprotein levels considered optimal, abnormal, or reflective of risk; increased focus on primary prevention through use of Framingham risk scoring to define risk in persons with multiple lipid/nonlipid risk factors; and increased focus on the association of the metabolic syndrome with CHD risk. The introduction of the category of CHD risk equivalents-including persons with atherosclerotic disease, diabetes, or 10-year CHD risk > 20% based on Framingham scoring-results in an increase over previous guidelines in the proportion of patients categorized as being at high risk and therefore eligible for more intensive low-density lipoprotein cholesterol (LDL-C)-lowering therapy. Use of the new secondary therapeutic target of non-high-density lipoprotein cholesterol should improve management of lipid risk factors in patients who have elevated triglyceride levels after LDL-C goals have been met. These new features of the NCEP ATP III guidelines should improve identification and treatment of patients with dyslipidemias associated with CHD risk.

  8. Dramatization and attraction: new identification tools

    Directory of Open Access Journals (Sweden)

    V I Panteleeva

    2009-12-01

    Full Text Available The article provides the analysis of identification mechanisms and its presentation patterns in the contemporary megapolis, the reasons for identification challenges emerging in the contemporary multicultural world where the contemporary urban community offers the opportunity for identity transformation, so that the citizens of metropolis are faced with the challenge of finding new identification tools. The notions of «dramatization» and «social attraction» offered in the article for the identity problem analysis in the context of diverse style and taste options of the contemporary urban community serve to form an estimate of the behaviour of an individual who keeps deciding on his own behavioral pattern.

  9. The aesthetics of Harold Pinter's dramatic art

    Directory of Open Access Journals (Sweden)

    Šoškić Radoje V.

    2011-01-01

    Full Text Available The British playwright Harold Pinter (1930-2008 is undoubtedly one of the greatest and most extraordinary modern playwrights, with the writing career which spanned over fifty years. The world Pinter depicts in his dramas is deeply political, violent, malevolent, and absurd at the same time, and is certainly reflective of dread, the precarious condition inhabited by most of contemporary humanity. A whole gallery of Pinter's characters (in his early plays are not driven by ambition to make progress in such a world, they don't care to dispute the public arena, they are uninterested in changing the world for better or for worse. On the contrary, those characters are sad citizens of intimacy, fear, the horrific nature of which unmasks itself in claustrophobic rooms they are entrapped in, where power games, domination, and the struggle for liberation originate. Pinter's characters are obsessed only with their own survival, governed by the 'territorial imperative'. The paper aims at analyzing thematic preoccupations, dramatic devices and major dramatic and poetic elements of Pinter's plays, with the emphasis on his connection with the 'Theatre of the Absurd'. The focus is also on the concept of the hidden violence of language and linguistic absurdity as used by Pinter.

  10. The dramatic extraction construction in French

    Directory of Open Access Journals (Sweden)

    Anne Abeillé

    2009-01-01

    Full Text Available Relying on spoken corpora (Corpaix, CRFP and on previous studies (Sabio 1995, 1996, we identify a construction common in spoken French, which we analyze as a particular case of extraction:a. dix sept ans il a. (Seventeen years he has [Corpaix]b. deux cigarettes j'ai fumé. (Two cigarettes I smoked [on the fly]The construction can only be a root clause and a declarative clause. Its interpretation is that of a thetic proposition. On the other hand, it is not associated with a unique information structure, since it is compatible with a focus-ground partition, with the extracted constotunet as a narrow focus, or with an all focus interpretation. We call this construction ‘dramatic extraction’, and the extracted element a ‘center’ (i.e. a focus or a figure. We formalize our analysis in the HPSG grammar.

  11. Dramatic response to infliximab in refractory neurosarcoidosis

    Directory of Open Access Journals (Sweden)

    Chintamaneni Sreekanth

    2010-01-01

    Full Text Available Sarcoidosis is a systemic disease characterized by noncaseating granulomas in the involved organs. Neurologic manifestations involving the central and/or peripheral nervous system occur in about 5% of patients. Neurosarcoidosis is often refractory to conventional treatment and therefore more effective treatment options are needed. While the etiology of the disease is still unknown, there is now a better understanding of its pathogenesis on a molecular level. It is clear that tumor necrosis factor-α (TNFα plays a pivotal role in the development of the granulomas and it is believed to be a key cytokine involved in the pathogenesis of the disease. Taking advantage of this better understanding of disease pathogenesis, anti-TNFα agents are being increasingly used to treat refractory sarcoidosis. We report a patient with refractory neurosarcoidosis who showed dramatic improvement in the clinical and radiological manifestations following treatment with infliximab; he suffered a relapse upon discontinuation of the medication.

  12. The Transformational Qualities of Dramatic Arts

    Directory of Open Access Journals (Sweden)

    Laura Gardner Salazar

    2014-05-01

    Full Text Available During the International Drama and Education Association (IDEA Congress in Kenya in 1998, the life of two educators crossed roads. Although both are from different geographical contexts (Colombia and the United States, they have shared the same passion: to encourage in their societies the implementation of dramatic arts in different educational settings (schools, universities, communities so children and adults could develop to their fullest, thus enabling them to participate actively in building a more democratic society. Fifteen years after this encounter, they met again in the 2013 IDEA Congress in Paris to reflect on their efforts during their life spans. Through examining their drama practices, they discuss how this human expression functions as a critical thinking art form, changing players, audiences, and communities. Lessons derived from their experiences might be useful for a new generation of transformational drama leaders.

  13. Programming of adaptive repair process chains using repair features and function blocks

    Directory of Open Access Journals (Sweden)

    Gunter Spöcker

    2016-01-01

    Full Text Available The current trends of product customization and repair of high value parts with individual defects demand automation and a high degree of flexibility of the involved manufacturing process chains. To determine the corresponding requirements this paper gives an overview of manufacturing process chains by distinguishing between horizontal and vertical process chains. The established way of modeling and programming processes with CAx systems and existing approaches is shown. Furthermore, the different types of possible adaptions of a manufacturing process chain are shown and considered as a cascaded control loop. Following this it is discussed which key requirements of repair process chains are unresolved by existing approaches. To overcome the deficits this paper introduces repair features which comprise the idea of geometric features and defines analytical auxiliary geometries based on the measurement input data. This meets challenges normally caused by working directly on reconstructed geometries in the form of triangulated surfaces which are prone to artifacts. Embedded into function blocks, this allows the use of traditional approaches for manufacturing process chains to be applied to adaptive repair process chains.

  14. Artificial Neural Networks and Gene Expression Programing based age estimation using facial features

    Directory of Open Access Journals (Sweden)

    Baddrud Z. Laskar

    2015-10-01

    Full Text Available This work is about estimating human age automatically through analysis of facial images. It has got a lot of real-world applications. Due to prompt advances in the fields of machine vision, facial image processing, and computer graphics, automatic age estimation via faces in computer is one of the dominant topics these days. This is due to widespread real-world applications, in areas of biometrics, security, surveillance, control, forensic art, entertainment, online customer management and support, along with cosmetology. As it is difficult to estimate the exact age, this system is to estimate a certain range of ages. Four sets of classifications have been used to differentiate a person’s data into one of the different age groups. The uniqueness about this study is the usage of two technologies i.e., Artificial Neural Networks (ANN and Gene Expression Programing (GEP to estimate the age and then compare the results. New methodologies like Gene Expression Programing (GEP have been explored here and significant results were found. The dataset has been developed to provide more efficient results by superior preprocessing methods. This proposed approach has been developed, tested and trained using both the methods. A public data set was used to test the system, FG-NET. The quality of the proposed system for age estimation using facial features is shown by broad experiments on the available database of FG-NET.

  15. CROSS-CULTURAL COMMUNICATION AND DRAMATIC RITUAL.

    Science.gov (United States)

    SALISBURY, LEE H.

    THE AUTHOR'S PROGRAM, COLLEGE ORIENTATION PROGRAM FOR ALASKAN NATIVES (COPAN), WAS DEVELOPED TO PROVIDE A SMOOTH TRANSITION FOR NATIVE ALASKAN STUDENTS INTO THE AREA OF WESTERN CULTURE, IN COLLEGE. THE FINE ARTS WERE UTILIZED AS A COMMUNICATION BRIDGE BETWEEN THE ESKIMO AND WESTERN CULTURES. THE MEDIA OF THE DANCE AND DRAMA WERE THE BASES FOR…

  16. Initial experience with a risk-sharing in vitro fertilization-embryo transfer program with novel features.

    Science.gov (United States)

    Stassart, Jacques P; Bayless, Romaine B; Casey, Colleen L; Phipps, William R

    2011-06-01

    To describe outcomes of the first 100 consecutive infertility patients participating in a risk-sharing program with uncomplicated eligibility requirements. The program included the costs of FSH-containing gonadotropin preparations and provided a full payment refund if no birth occurred that resulted in a normal infant surviving to an age of 1 month. Retrospective cohort study. Private IVF center. Infertility patientsrisk-sharing program with uncomplicated eligibility requirements are very likely to have a successful pregnancy. Other centers may wish to incorporate some of the described program's features into their own risk-sharing IVF programs. Copyright © 2011. Published by Elsevier Inc.

  17. Dramatic Change in Jupiter's Great Red Spot

    Science.gov (United States)

    Simon, A. A.; Wong, M. H.; Rogers, J. H.; Orton, G. S.; de Pater, I.; Asay-Davis, X.; Carlson, R. W.; Marcus, P. S.

    2015-01-01

    Jupiter's Great Red Spot (GRS) is one of its most distinct and enduring features, having been continuously observed since the 1800's. It currently spans the smallest latitude and longitude size ever recorded. Here we show analyses of 2014 Hubble spectral imaging data to study the color, structure and internal dynamics of this long-live storm.

  18. Revealing metabolite biomarkers for acupuncture treatment by linear programming based feature selection.

    Science.gov (United States)

    Wang, Yong; Wu, Qiao-Feng; Chen, Chen; Wu, Ling-Yun; Yan, Xian-Zhong; Yu, Shu-Guang; Zhang, Xiang-Sun; Liang, Fan-Rong

    2012-01-01

    Acupuncture has been practiced in China for thousands of years as part of the Traditional Chinese Medicine (TCM) and has gradually accepted in western countries as an alternative or complementary treatment. However, the underlying mechanism of acupuncture, especially whether there exists any difference between varies acupoints, remains largely unknown, which hinders its widespread use. In this study, we develop a novel Linear Programming based Feature Selection method (LPFS) to understand the mechanism of acupuncture effect, at molecular level, by revealing the metabolite biomarkers for acupuncture treatment. Specifically, we generate and investigate the high-throughput metabolic profiles of acupuncture treatment at several acupoints in human. To select the subsets of metabolites that best characterize the acupuncture effect for each meridian point, an optimization model is proposed to identify biomarkers from high-dimensional metabolic data from case and control samples. Importantly, we use nearest centroid as the prototype to simultaneously minimize the number of selected features and the leave-one-out cross validation error of classifier. We compared the performance of LPFS to several state-of-the-art methods, such as SVM recursive feature elimination (SVM-RFE) and sparse multinomial logistic regression approach (SMLR). We find that our LPFS method tends to reveal a small set of metabolites with small standard deviation and large shifts, which exactly serves our requirement for good biomarker. Biologically, several metabolite biomarkers for acupuncture treatment are revealed and serve as the candidates for further mechanism investigation. Also biomakers derived from five meridian points, Zusanli (ST36), Liangmen (ST21), Juliao (ST3), Yanglingquan (GB34), and Weizhong (BL40), are compared for their similarity and difference, which provide evidence for the specificity of acupoints. Our result demonstrates that metabolic profiling might be a promising method to

  19. Dramatic Demand Reduction In The Desert Southwest

    Energy Technology Data Exchange (ETDEWEB)

    Boehm, Robert [Univ. of Nevada, Las Vegas, NV (United States); Hsieh, Sean [Univ. of Nevada, Las Vegas, NV (United States); Lee, Joon [Univ. of Nevada, Las Vegas, NV (United States); Baghzouz, Yahia [Univ. of Nevada, Las Vegas, NV (United States); Cross, Andrew [Univ. of Nevada, Las Vegas, NV (United States); Chatterjee, Sarah [NV Energy, Las Vegas, NV (United States)

    2015-07-06

    adjusting settings. In a sense the customer can choose between greater comfort and greater money savings during demand response circumstances. Finally a battery application was to be considered. Initially it was thought that a large battery (probably a sodium-sulfur type) would be installed. However, after the contract was awarded, it was determined that a single, centrally-located battery system would not be appropriate for many reasons, including that with the build out plan there would not be any location to put it. The price had risen substantially since the budget for the project was put together. Also, that type of battery has to be kept hot all the time, but its use was only sought for summer operation. Hence, individual house batteries would be used, and these are discussed at the end of this report. Many aspects of the energy use for climate control in selected houses were monitored before residents moved in. This was done both to understand the magnitude of the energy flows but also to have data that could be compared to the computer simulations. The latter would be used to evaluate various aspects of our plan. It was found that good agreement existed between actual energy use and computed energy use. Hence, various studies were performed via simulations. Performance simulations showed the impact on peak energy usage between a code built house of same size and shape compared to the Villa Trieste homes with and without the PV arrays on the latter. Computations were also used to understand the effect of varying orientations of the houses in this typical housing development, including the effect of PV electrical generation. Energy conservation features of the Villa Trieste homes decreased the energy use during peak times (as well as all others), but the resulting decreased peak occurred at about the same time as the code-built houses. Consideration of the PV generation decreases the grid energy use further during daylight hours, but did not extend long enough many

  20. Maverick Comet Splits during Dramatic Outburst

    Science.gov (United States)

    1996-01-01

    New ESO Observations of P/Schwassmann-Wachmann 3 A few months ago, Periodic Comet Schwassmann-Wachmann 3 underwent a dramatic and completely unexpected, thousand-fold brightening. At that time, the cause for this interesting event was unknown. However, observations with the two largest ESO telescopes have now shown that the ``dirty snowball'' nucleus of this comet has recently split into at least four individual pieces [1]. There is little doubt that the outburst and the splitting event(s) are closely related and that the greatly increased dust and gas production is due to ``fresh'' material of the icy cometary nucleus becoming exposed to the surrounding space for the first time. A Comet with a Troubled History Comet Schwassmann-Wachmann 3 was discovered on May 2, 1930, on a photographic plate obtained at the Hamburg Observatory (Germany) by two astronomers at this institution, Arnold Schwassmann and Arthur Arno Wachmann. The subsequent observations showed that the comet moved in an elliptical orbit with a revolution period of somewhat more than 5 years. Great efforts were expended to observe the comet during the next returns, but it was not recovered until nearly 50 years and eight revolutions later, when its faint image was found of a plate obtained in August 1979 with a telescope at the Perth Observatory in Western Australia. It was missed in 1984, but was sighted again in 1989 and most recently in 1994. Thus this comet has only been observed during four out of thirteen approaches since 1930. While this may be partly due to a less advantageous location in the sky at some returns, it is also a strong indication that the comet behaves unpredictably and must have a quite variable brightness. For the sake of convenience this comet is often referred to as ``SW-3'' by professional astronomers. Recent orbital calculations have shown that it was inserted into the present, short-period orbit by the strong gravitational pull of Jupiter during several, relatively close

  1. Digital compared to screen-film mammography: breast cancer prognostic features in an organized screening program.

    Science.gov (United States)

    Prummel, Maegan V; Done, Susan J; Muradali, Derek; Majpruz, Vicky; Brown, Patrick; Jiang, Hedy; Shumak, Rene S; Yaffe, Martin J; Holloway, Claire M B; Chiarelli, Anna M

    2014-09-01

    Our previous study found cancer detection rates were equivalent for direct radiography compared to screen-film mammography, while rates for computed radiography were significantly lower. This study compares prognostic features of invasive breast cancers by type of mammography. Approved by the University of Toronto Research Ethics Board, this study identified invasive breast cancers diagnosed among concurrent cohorts of women aged 50-74 screened by direct radiography, computed radiography, or screen-film mammography from January 1, 2008 to December 31, 2009. During the study period, 816,232 mammograms were performed on 668,418 women, and 3,323 invasive breast cancers were diagnosed. Of 2,642 eligible women contacted, 2,041 participated (77.3 %). The final sample size for analysis included 1,405 screen-detected and 418 interval cancers (diagnosed within 24 months of a negative screening mammogram). Polytomous logistic regression was performed to evaluate the association between tumour characteristics and type of mammography, and between tumour characteristics and detection method. Odds ratios (OR) and 95 % confidence intervals (CI) were recorded. Cancers detected by computed radiography compared to screen-film mammography were significantly more likely to be lymph node positive (OR 1.94, 95 %CI 1.01-3.73) and have higher stage (II:I, OR 2.14, 95 %CI 1.11-4.13 and III/IV:I, OR 2.97, 95 %CI 1.02-8.59). Compared to screen-film mammography, significantly more cancers detected by direct radiography (OR 1.64, 95 %CI 1.12-2.38) were lymph node positive. Interval cancers had worse prognostic features compared to screen-detected cancers, irrespective of mammography type. Screening with computed radiography may lead to the detection of cancers with a less favourable stage distribution compared to screen-film mammography that may reflect a delayed diagnosis. Screening programs should re-evaluate their use of computed radiography for breast screening.

  2. Understanding Legacy Features with Featureous

    DEFF Research Database (Denmark)

    Olszak, Andrzej; Jørgensen, Bo Nørregaard

    2011-01-01

    Feature-centric comprehension of source code is essential during software evolution. However, such comprehension is oftentimes difficult to achieve due the discrepancies between structural and functional units of object-oriented programs. We present a tool for feature-centric analysis of legacy...... Java programs called Featureous that addresses this issue. Featureous allows a programmer to easily establish feature-code traceability links and to analyze their characteristics using a number of visualizations. Featureous is an extension to the NetBeans IDE, and can itself be extended by third...

  3. Multi-task feature selection in microarray data by binary integer programming

    OpenAIRE

    Lan, Liang; Vucetic, Slobodan

    2013-01-01

    A major challenge in microarray classification is that the number of features is typically orders of magnitude larger than the number of examples. In this paper, we propose a novel feature filter algorithm to select the feature subset with maximal discriminative power and minimal redundancy by solving a quadratic objective function with binary integer constraints. To improve the computational efficiency, the binary integer constraints are relaxed and a low-rank approximation to the quadratic ...

  4. Dance dramatization of a fairy tale Peter and the wolf

    OpenAIRE

    Bukovec, Klavdija

    2014-01-01

    The diploma entitled Dance dramatization of a fairy tale Peter and the Wolf describes the process of dance dramatization with preschool children. The theoretical part contains various definitions and elements of dance dramatization and the role of children and adults in it. Elements of dance dramatization are key factors as they present stages through which children encounter in the creation of the show. The chapter of musical fairy tale describes the musical fairy tale in detail, presen...

  5. The Challenges and Prospects of Teaching and Learning Dramatic ...

    African Journals Online (AJOL)

    Dramatic education is an all-inclusive academic discipline which uses as tools branches of learning that bear upon the dramatic impulse. It utilizes eclectically each and every single discipline into one unified body of knowledge, so that it can help man to comprehend the nature of experience. Educational drama or Dramatic ...

  6. Dramatic Advance in Quality in Flexographic Printing

    Directory of Open Access Journals (Sweden)

    Jochen Richter

    2004-12-01

    Full Text Available The enormous changes in flexography printing in recent years concerning the printing quality achievable cannot generally be ascribed to a single revolutionary invention, but are the result of continuous developments to the complete system. Thus the direct drive technology in all machine types and its associated advantages in terms of printing length corrections has become established since drupa 2000. The race for ever finer raster rolls has also been completed to the benefit of improvements in bowl geometry and in ceramic surfaces. Clearly improved colour transfer behaviour has become feasible as a result. In a closely intermeshed system such as flexography printing this naturally has to have an effect on the printing colours used. Further improvements in bonding agents and pigment concentrations now allow users to print ever thinner colour layers while maintaining all of the required authenticities.Furthermore, it has become possible to reduce additional disturbing characteristics in the UV colour area, such as the unpleasant odour. While the digital imaging of printing plates has primarily been improved in terms of economic efficiency by the use of up to eight parallel laser beams, extreme improvements in the system are noticeable especially in the area of directly engraved printing moulds. Whereas many still dismissed directly engraved polymer plates at the last drupa as a laboratory system, the first installation was recently placed on the market a mere three years later. A further noteworthy innovation of recent years that has reached market maturity is thin sleeve technology, which combines the advantages of a photopolymer plate with a round imaged printing mould. There are no high sleeve costs for each printing mould, except for one-off cost for an adapter sleeve. To conclude, it can be said that although flexography printing has experienced many new features in the time between drupa 2000 and today, it still has enormous potential for

  7. A method of evolving novel feature extraction algorithms for detecting buried objects in FLIR imagery using genetic programming

    Science.gov (United States)

    Paino, A.; Keller, J.; Popescu, M.; Stone, K.

    2014-06-01

    In this paper we present an approach that uses Genetic Programming (GP) to evolve novel feature extraction algorithms for greyscale images. Our motivation is to create an automated method of building new feature extraction algorithms for images that are competitive with commonly used human-engineered features, such as Local Binary Pattern (LBP) and Histogram of Oriented Gradients (HOG). The evolved feature extraction algorithms are functions defined over the image space, and each produces a real-valued feature vector of variable length. Each evolved feature extractor breaks up the given image into a set of cells centered on every pixel, performs evolved operations on each cell, and then combines the results of those operations for every cell using an evolved operator. Using this method, the algorithm is flexible enough to reproduce both LBP and HOG features. The dataset we use to train and test our approach consists of a large number of pre-segmented image "chips" taken from a Forward Looking Infrared Imagery (FLIR) camera mounted on the hood of a moving vehicle. The goal is to classify each image chip as either containing or not containing a buried object. To this end, we define the fitness of a candidate solution as the cross-fold validation accuracy of the features generated by said candidate solution when used in conjunction with a Support Vector Machine (SVM) classifier. In order to validate our approach, we compare the classification accuracy of an SVM trained using our evolved features with the accuracy of an SVM trained using mainstream feature extraction algorithms, including LBP and HOG.

  8. Key Features of Management of Technology (MoT) Undergraduate Program in Malaysia

    Science.gov (United States)

    Shamsuddin, Alina; Abdullah, Nor Hazana; Wahab, Eta

    2011-01-01

    Management of Technology (MoT) Education is growing both in numbers and importance. There are more than 200 universities in the world that are offering MoT programs. However, these universities have taken different approaches with respect to the names and designs of the programs. In Malaysia, some of the programs are known as Technology…

  9. Exploring the Unique Features of a First Nations Graduate-Level Social Work Program

    Directory of Open Access Journals (Sweden)

    Ralph C. Bodor

    2015-03-01

    Full Text Available Recently, a one-time cohort of graduate-level social work students completed a unique MSW program. The program was delivered in partnership between the Faculty of Social Work, University of Calgary and Blue Quills First Nations College and, of the twenty four graduates; twenty-one were of First Nations or Me´tis ancestry. The program honored traditional knowledge and ways of learning combined with a critical analysis of Western perspectives of social work knowledge. Strong fiscal resources enabled the program to establish a formal support network for the students and to support the development of Indigenous curriculum and programming that encouraged success for the students. The program was fundamentally different than urban on-campus programs while still maintaining graduate level accreditation requirements. This analysis of the program required the use of Indigenous Research Methodology to collect and create an understanding of the program. Instructors commented on the centered, empowered, balanced, and congruent students. The formal and informal, concrete and invisible supports to the students ensured the success of this program and this cohort of students. As one student commented, the program started in ceremony, ended in ceremony, and could not fail within the context ceremony.

  10. Discriminant Feature Selection by Genetic Programming: Towards a domain independent multi-class object detection system.

    Directory of Open Access Journals (Sweden)

    Jacques-André Landry

    2005-02-01

    Full Text Available In order to implement a multi-class object detection system, an efficient object representation is needed; in this short paper, we present a feature selection method based on the Genetic Algorithm paradigm. This method allows for the identification of a set of features that best represent the classes in the problem at hand. The idea would then be to have a broad set of features to describe any object, and then to use the presented feature selection method to adapt the description to the actual needs of the classification problem. Furthermore, the tree like solutions generated by the method can be interpreted and modified for increased generality. A brief review of literature, the first implementation of the method and the first results are presented here. The method shows potential to be used as a building block of a detection system, although further experimentation is underway in order to fully asses the power of the method.

  11. Automated identification of protein-ligand interaction features using Inductive Logic Programming: a hexose binding case study

    Directory of Open Access Journals (Sweden)

    A Santos Jose C

    2012-07-01

    Full Text Available Abstract Background There is a need for automated methods to learn general features of the interactions of a ligand class with its diverse set of protein receptors. An appropriate machine learning approach is Inductive Logic Programming (ILP, which automatically generates comprehensible rules in addition to prediction. The development of ILP systems which can learn rules of the complexity required for studies on protein structure remains a challenge. In this work we use a new ILP system, ProGolem, and demonstrate its performance on learning features of hexose-protein interactions. Results The rules induced by ProGolem detect interactions mediated by aromatics and by planar-polar residues, in addition to less common features such as the aromatic sandwich. The rules also reveal a previously unreported dependency for residues cys and leu. They also specify interactions involving aromatic and hydrogen bonding residues. This paper shows that Inductive Logic Programming implemented in ProGolem can derive rules giving structural features of protein/ligand interactions. Several of these rules are consistent with descriptions in the literature. Conclusions In addition to confirming literature results, ProGolem’s model has a 10-fold cross-validated predictive accuracy that is superior, at the 95% confidence level, to another ILP system previously used to study protein/hexose interactions and is comparable with state-of-the-art statistical learners.

  12. Utilisation of Perkin-Elmer Operating System Features to Optimise Programming Efficiency

    OpenAIRE

    Gray, L.S.; Morris, A.S.

    1982-01-01

    This paper consists of printed notes given as the first lecture of a two-part special lecture course on efficient programming. Emphasis is laid on on efficient programming in relation to the hardware and operating system of the Perkin-Elmer 3220 computer, although the principles embodied are in general, universally applicable. The functioning of the operating system and its interaction with the hardware of the computer is explained in considerable detail, as this is felt a necessary prerequis...

  13. The Identification, Implementation, and Evaluation of Critical User Interface Design Features of Computer-Assisted Instruction Programs in Mathematics for Students with Learning Disabilities

    Science.gov (United States)

    Seo, You-Jin; Woo, Honguk

    2010-01-01

    Critical user interface design features of computer-assisted instruction programs in mathematics for students with learning disabilities and corresponding implementation guidelines were identified in this study. Based on the identified features and guidelines, a multimedia computer-assisted instruction program, "Math Explorer", which delivers…

  14. dramatization of character in selected nigerian short stories

    African Journals Online (AJOL)

    Characterization in the short story endears the short story genre more to the conventions of the stage because of its dramatization of character. By paying strict attention to the manipulation of action and dialogue, the short story writer creates dramatic characters who illuminate setting, promote the plot and ultimately realize ...

  15. Decidedly Dramatic! The Power of Creative Drama in Social Studies

    Science.gov (United States)

    Pieczura, Michelle

    2013-01-01

    Creative dramatics, a highly effective method for integrating arts education into core curriculum, produces a positive and lasting impact on student learning, in terms of creative and critical thinking, language development, listening, comprehension, retention, cooperation, and empathy and awareness of others. Creative dramatics not only has the…

  16. Dramatics in the Classroom: Making Lessons Come Alive. Fastback 70.

    Science.gov (United States)

    Kelly, Elizabeth Flory

    The contents of this booklet focus on effective techniques for using dramatics in the classroom and are based on the premise that drama can integrate all skills and help to avoid fragmentation in learning. Chapters discuss motivating the dreamers in the classroom, curriculum dramatics--eclectic teaching, training the teacher, transforming the…

  17. The Challenges and Prospects of Teaching and Learning Dramatic ...

    African Journals Online (AJOL)

    DR Nneka

    Abstract. Dramatic education is an all-inclusive academic discipline which uses as tools branches of learning that bear upon the dramatic impulse. It utilizes eclectically each and every single discipline into one unified body of knowledge, so that it can help man to comprehend the nature of experience. Educational drama or ...

  18. Making automated computer program documentation a feature of total system design

    Science.gov (United States)

    Wolf, A. W.

    1970-01-01

    It is pointed out that in large-scale computer software systems, program documents are too often fraught with errors, out of date, poorly written, and sometimes nonexistent in whole or in part. The means are described by which many of these typical system documentation problems were overcome in a large and dynamic software project. A systems approach was employed which encompassed such items as: (1) configuration management; (2) standards and conventions; (3) collection of program information into central data banks; (4) interaction among executive, compiler, central data banks, and configuration management; and (5) automatic documentation. A complete description of the overall system is given.

  19. The classical dramatic text and its value in contemporary theatre

    Directory of Open Access Journals (Sweden)

    Nina Žavbi Milojević

    2013-06-01

    Full Text Available This paper deals with the classical dramatic text and its staging in contemporary theatre. Specifically, it aims to show that classical texts can address topical issues. This is illustrated by the example of several stagings of Ivan Cankar’s Hlapci, one of the most influential dramatic texts in Slovene literature. The history of this dramatic text is presented from its first publication and reception to the different stagings in various Slovene professional theatres. The focus is on how the situation in Slovene society is reflected in each examined staging. The drama Hlapci was first staged almost one hundred years ago, when the staging followed closely the dramatic text. However, after 1980 stagings became more independent from the text and more artistic freedom was allowed. The paper will prove that classical dramatic texts are very appropriate for staging in contemporary theatre, especially with an innovative director’s approach.

  20. Program of Adaptation Assistance in Foster Families and Particular Features of Its Implementation

    Science.gov (United States)

    Zakirova, Venera G.; Gaysina, Guzel I.; Zhumabaeva, Asia

    2015-01-01

    Relevance of the problem stated in the article, conditioned by the fact that the successful adaptation of orphans in a foster family requires specialized knowledge and skills, as well as the need of professional support. Therefore, this article aims at substantiation of the effectiveness of the developed pilot program psycho-pedagogical support of…

  1. Mantle of the Expert: Integrating Dramatic Inquiry and Visual Arts in Social Studies

    Science.gov (United States)

    Johnson, Edric C.; Liu, Katrina; Goble, Kristin

    2015-01-01

    This article introduces the social studies field to Dorothy Heatchote's Mantle of Expert (MOE). MOE is a dramatic inquiry approach used in several subject areas and can work at all levels in the social studies curriculum. The authors go into the development of using this approach in an elementary and middle teacher education program. After sharing…

  2. Theodramatic Rehearsal: Fighting Self-Deception through the Dramatic Imagination

    Directory of Open Access Journals (Sweden)

    Brett Vaden

    2014-03-01

    Full Text Available This paper seeks to appropriate the insights of dramatic theology for Christian psychology and soul care. According to Kevin Vanhoozer, Scripture is the ‘script’ for human beings’ fitting participation in the acts and deeds of God in the world (i.e., ‘theodrama’. Keeping with this dramatic paradigm, the author will explore what ‘rehearsal’ might entail by drawing from a branch of psychotherapy called ‘psychodrama.’ The main question to be addressed in this appropriation of dramatic theology is, “How might dramatic rehearsal combat self-deception?” The author will only begin to answer this question, but in the attempt it is hoped that further reflection and clarity will be induced.

  3. Grieg: Songs and dramatic works with orchestra. / Alan Blyth

    Index Scriptorium Estoniae

    Blyth, Alan

    1993-01-01

    Uuest heliplaadist "Grieg: Songs and dramatic works with orchestra. Barbara Bonney, Randi Stene, Hakan Hagegard, Ruth Tellefsen, Gothenburg Symphony Chorus and Orchestra, Neeme Järvi." CD 437 519 - 2GH

  4. A Design Case Featuring the Graduate Design Studio at Indiana University Bloomington’s Human-Computer Interaction Design Program

    Directory of Open Access Journals (Sweden)

    Matthew Callison

    2011-01-01

    Full Text Available In this article the author illustrates the design of a physical space that was created to serve as a performance intervention for graduate students in the Human-Computer Interaction Design (HCId program in the School of Informatics, Indiana University Bloomington. Opened in Fall 2010, the HCId Graduate Design Studio was designed to help facilitate collaboration between students and faculty in the HCId Program. An effort was made to document the Studio and students working in the Studio over an extended period of time. The author visited the Design Studio a minimum of ten times between late January and late April 2011. Visits were conducted on different days of the week (Monday - Friday and at different times of the day to capture a variety of students and activity level in the Studio. In order to gain a perspective on the two distinct groups of students who utilize the Studio, interviews of graduate students from both the HCId Master of Science and Doctoral program were conducted. In addition interviews were conducted of two other important stakeholders, the HCId Program Director and the Director of Facilities for the School of Informatics, both of whom were heavily involved in the design of the Studio. Through faculty and student interviews, text descriptions, photographs, and audio and video recordings this article addresses the design features and their impact, both successful and unsuccessful, on student and faculty collaboration of the HCId Graduate Design Studio.

  5. Alliteration as a Means of Characterization of Dramatic Personae: A Translation Issue

    Directory of Open Access Journals (Sweden)

    Tomaž Onič

    2006-06-01

    Full Text Available Alliteration is usually defined as a repetition of the same initial consonant in consecutive or neighbouring words. Despite its importance for dramatic construction; alliteration is rarely preserved in Slovene translations of dramatic texts. Detailed research into this phenomenon in several British and American plays and their Slovene translations showed that the survival of alliterations in the translation process is mostly random. On the rare occasions when alliteration is preserved; no proof could be found of a clear translation strategy focusing on this linguistic element. Since alliteration in most cases appears not as an isolated language element but rather as one of many important text features; the translator should devise priorities. The purpose of this article is not to urge translators to give alliteration the highest priority; but merely to suggest its inclusion among the features considered. This paper also includes examples of non-preservance of alliteration in translated text illustrating the loss for the text and its implications.

  6. Low-level feature extraction for edge detection using genetic programming.

    Science.gov (United States)

    Fu, Wenlong; Johnston, Mark; Zhang, Mengjie

    2014-08-01

    Edge detection is a subjective task. Traditionally, a moving window approach is used, but the window size in edge detection is a tradeoff between localization accuracy and noise rejection. An automatic technique for searching a discriminated pixel's neighbors to construct new edge detectors is appealing to satisfy different tasks. In this paper, we propose a genetic programming (GP) system to automatically search pixels (a discriminated pixel and its neighbors) to construct new low-level subjective edge detectors for detecting edges in natural images, and analyze the pixels selected by the GP edge detectors. Automatically searching pixels avoids the problem of blurring edges from a large window and noise influence from a small window. Linear and second-order filters are constructed from the pixels with high occurrences in these GP edge detectors. The experiment results show that the proposed GP system has good performance. A comparison between the filters with the pixels selected by GP and all pixels in a fixed window indicates that the set of pixels selected by GP is compact but sufficiently rich to construct good edge detectors.

  7. A review of the safety features of 6M packagings for DOE programs

    Energy Technology Data Exchange (ETDEWEB)

    1988-12-01

    This report, prepared by a US Department of Energy (DOE) Task Force and organized for clarity into two-page modules, argues that the US Department of Transportation (DOT) Specification-6M packagings (hereafter referred to as 6M packaging, or simply 6M) merit continued DOE use and, if necessary, DOE certification. This report is designed to address the specific requirements of a Safety Analysis Report for Packaging (SARP). While not a SARP, this report constitutes a compilation of all available documentation on 6M packagings. The authors individually, and the Task Force collectively, believe their investigation provides justification for the continued use of 6M packagings because they meet criteria for quality assurance and for safety under normal and accident conditions as defined by the US Nuclear Regulatory Commission (NRC) regulations. This report may be used by DOE managers to assist in deliberations on future requirements for 6M packagings as they are required to support DOE programs. For the purpose of ready evaluation, this report includes categorical topics found in Nuclear Regulatory Guide 7.9, the topical guideline for SARPs. The format, however, will (it is hoped) pleasantly surprise customary reader expectations. For, while maintaining categorical headings and subheadings found in SARPs as a skeleton, the Task Force chose to adopt the document design principles developed by Hughes Aircraft in the 1960s, ''Sequential Thematic Organization of Publications'' (STOP). 37 figs.

  8. Narrative and Dramatic Structure in Plato\\'s Dialogues

    Directory of Open Access Journals (Sweden)

    M Pourelm

    2013-03-01

    Full Text Available Plato did not allow many artists and poets into his Utopia Republic because of their bad and misleading influence on the young. But it seems that he learned storytelling and narrating from them and concealed what he learned beneath his philosophy. Thus, Plato's dialogues became more effective and gained aesthetic and artistic qualities. Theaetetus, one of the best known dialogues of Plato, is a conversation and discussion about episteme. Due to using classical dramatic structure, this dialogue is the most important dialogue with regard to dramatization of philosophical thoughts. The goal of this article is to study the dramatic structure of Plato's dialogues and show its potentials for interaction with narrative theories. It could be said that Plato's dialogues have many resemblances to the Greek drama and, today, we can call Plato a playwright. Thus, it is important and necessary to reread and reevaluate Plato's works via narratological view.

  9. Association between U.S. state AIDS Drug Assistance Program (ADAP features and HIV antiretroviral therapy initiation, 2001-2009.

    Directory of Open Access Journals (Sweden)

    David B Hanna

    Full Text Available U.S. state AIDS Drug Assistance Programs (ADAPs are federally funded to provide antiretroviral therapy (ART as the payer of last resort to eligible persons with HIV infection. States differ regarding their financial contributions to and ways of implementing these programs, and it remains unclear how this interstate variability affects HIV treatment outcomes.We analyzed data from HIV-infected individuals who were clinically-eligible for ART between 2001 and 2009 (i.e., a first reported CD4+ <350 cells/uL or AIDS-defining illness from 14 U.S. cohorts of the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD. Using propensity score matching and Cox regression, we assessed ART initiation (within 6 months following eligibility and virologic suppression (within 1 year based on differences in two state ADAP features: the amount of state funding in annual ADAP budgets and the implementation of waiting lists. We performed an a priori subgroup analysis in persons with a history of injection drug use (IDU.Among 8,874 persons, 56% initiated ART within six months following eligibility. Persons living in states with no additional state contribution to the ADAP budget initiated ART on a less timely basis (hazard ratio [HR] 0.73, 95% CI 0.60-0.88. Living in a state with an ADAP waiting list was not associated with less timely initiation (HR 1.12, 95% CI 0.87-1.45. Neither additional state contributions nor waiting lists were significantly associated with virologic suppression. Persons with an IDU history initiated ART on a less timely basis (HR 0.67, 95% CI 0.47-0.95.We found that living in states that did not contribute additionally to the ADAP budget was associated with delayed ART initiation when treatment was clinically indicated. Given the changing healthcare environment, continued assessment of the role of ADAPs and their features that facilitate prompt treatment is needed.

  10. Impacts of Dramatic Theory and Criticism on the Development of ...

    African Journals Online (AJOL)

    It briefly discusses the recurrent controversies between the Western dramatic weltanschauung vis-à-vis the African cosmology in terms of the theoretical impacts of the former on the latter, concluding that the need for African theory and criticism to come of age cannot be overemphasized. LWATI: A Journal of Contemporary ...

  11. Content familiarity, attitude and achievement in dramatic literature-in ...

    African Journals Online (AJOL)

    The results further showed that content familiarity (β =.18, t= 2.35, P<.05) could predict students' achievement in dramatic Literature in English. Based on the findings of the research, it is recommended that school authorities and the government should make available, in school libraries, literature texts that are relevant to the ...

  12. Building Family and Community Demand for Dramatic Change in Schools

    Science.gov (United States)

    Brinson, Dana; Steiner, Lucy

    2012-01-01

    District-led, dramatic change efforts in failing schools--including turnarounds and school closures--often face strong resistance from families and communities. Resistance may be based on years of tension and distrust between districts and communities, failed past school improvement efforts, or a lack of understanding about the chasm between a…

  13. Authoring for Engagement in Interactive Dramatic Experiences for Learning

    DEFF Research Database (Denmark)

    Schoenau-Fog, Henrik; Bruni, Luis Emilio; Khalil, Faysal Fuad

    2013-01-01

    ’s control over communicating a theme. To address this problem, this paper contributes a method for organizing narrative events in a free-roaming virtual environment. The Interactive Dramatic Experience Model (IDEM) retains the freedom of navigation while maintaining the possibility to construct various...

  14. Use of Bilingual/Bicultural Education and Dramatization as Ancillary ...

    African Journals Online (AJOL)

    We found that Deaf and Hard of hearing learners who were exposed to instructional methods and strategies in the American Sign Language/English bilingual methods and dramatization performed exceptionally better than those taught using the Total Communication approach. Keywords: Special education, demonstration ...

  15. Association between U.S. State AIDS Drug Assistance Program (ADAP) Features and HIV Antiretroviral Therapy Initiation, 2001–2009

    Science.gov (United States)

    Hanna, David B.; Buchacz, Kate; Gebo, Kelly A.; Hessol, Nancy A.; Horberg, Michael A.; Jacobson, Lisa P.; Kirk, Gregory D.; Kitahata, Mari M.; Korthuis, P. Todd; Moore, Richard D.; Napravnik, Sonia; Patel, Pragna; Silverberg, Michael J.; Sterling, Timothy R.; Willig, James H.; Collier, Ann; Samji, Hasina; Thorne, Jennifer E.; Althoff, Keri N.; Martin, Jeffrey N.; Rodriguez, Benigno; Stuart, Elizabeth A.; Gange, Stephen J.

    2013-01-01

    Background U.S. state AIDS Drug Assistance Programs (ADAPs) are federally funded to provide antiretroviral therapy (ART) as the payer of last resort to eligible persons with HIV infection. States differ regarding their financial contributions to and ways of implementing these programs, and it remains unclear how this interstate variability affects HIV treatment outcomes. Methods We analyzed data from HIV-infected individuals who were clinically-eligible for ART between 2001 and 2009 (i.e., a first reported CD4+ <350 cells/uL or AIDS-defining illness) from 14 U.S. cohorts of the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD). Using propensity score matching and Cox regression, we assessed ART initiation (within 6 months following eligibility) and virologic suppression (within 1 year) based on differences in two state ADAP features: the amount of state funding in annual ADAP budgets and the implementation of waiting lists. We performed an a priori subgroup analysis in persons with a history of injection drug use (IDU). Results Among 8,874 persons, 56% initiated ART within six months following eligibility. Persons living in states with no additional state contribution to the ADAP budget initiated ART on a less timely basis (hazard ratio [HR] 0.73, 95% CI 0.60–0.88). Living in a state with an ADAP waiting list was not associated with less timely initiation (HR 1.12, 95% CI 0.87–1.45). Neither additional state contributions nor waiting lists were significantly associated with virologic suppression. Persons with an IDU history initiated ART on a less timely basis (HR 0.67, 95% CI 0.47–0.95). Conclusions We found that living in states that did not contribute additionally to the ADAP budget was associated with delayed ART initiation when treatment was clinically indicated. Given the changing healthcare environment, continued assessment of the role of ADAPs and their features that facilitate prompt treatment is needed. PMID:24260137

  16. Dramatic changes in electronic structure revealed by fractionally charged nuclei

    Energy Technology Data Exchange (ETDEWEB)

    Cohen, Aron J. [Department of Chemistry, Lensfield Rd., University of Cambridge, Cambridge CB2 1EW (United Kingdom); Mori-Sánchez, Paula, E-mail: paula.mori@uam.es [Departamento de Química, Universidad Autónoma de Madrid, 28049 Madrid (Spain)

    2014-01-28

    Discontinuous changes in the electronic structure upon infinitesimal changes to the Hamiltonian are demonstrated. These are revealed in one and two electron molecular systems by full configuration interaction (FCI) calculations when the realm of the nuclear charge is extended to be fractional. FCI electron densities in these systems show dramatic changes in real space and illustrate the transfer, hopping, and removal of electrons. This is due to the particle nature of electrons seen in stretched systems and is a manifestation of an energy derivative discontinuity at constant number of electrons. Dramatic errors of density functional theory densities are seen in real space as this physics is missing from currently used approximations. The movements of electrons in these simple systems encapsulate those in real physical processes, from chemical reactions to electron transport and pose a great challenge for the development of new electronic structure methods.

  17. Dramatic reduction of culture time of Mycobacterium tuberculosis

    Science.gov (United States)

    Ghodbane, Ramzi; Raoult, Didier; Drancourt, Michel

    2014-02-01

    Mycobacterium tuberculosis culture, a critical technique for routine diagnosis of tuberculosis, takes more than two weeks. Here, step-by-step improvements in the protocol including a new medium, microaerophlic atmosphere or ascorbic-acid supplement and autofluorescence detection dramatically shortened this delay. In the best case, primary culture and rifampicin susceptibility testing were achieved in 72 hours when specimens were inoculated directly on the medium supplemented by antibiotic at the beginning of the culture.

  18. Dramatic response to levetiracetam in post-ischaemic Holmes’ tremor

    Science.gov (United States)

    Striano, P; Elefante, Andrea; Coppola, Antonietta; Tortora, Fabio; Zara, Federico; Minetti, Carlo

    2009-01-01

    Holmes’ tremor refers to an unusual combination of rest, postural and kinetic tremor of extremities. Common causes of Holmes’ tremor include stroke, trauma, vascular malformations and multiple sclerosis, with lesions involving the thalamus, brain stem or cerebellum. Although some drugs (eg, levodopa and dopaminergic drugs, clonazepam and propranolol) have been occasionally reported to give some benefit, medical treatment of Holmes’ tremor is unsatisfactory, and many patients require thalamic surgery to achieve satisfactory control. We report a patient in whom post-ischaemic Holmes’ tremor dramatically responded to levetiracetam treatment. PMID:21686707

  19. An Investigation of Non-Thesis Master's Program Geography Teacher Candidates' Attitudes towards Teaching Profession regarding Several Socio-Cultural Features

    Science.gov (United States)

    Sezer, Adem; Kara, Hasan; Pinar, Adnan

    2011-01-01

    The purpose of this study is to examine the attitudes of non-thesis master's degree program: geography teacher candidates towards teaching profession regarding several socio-cultural features. The study was conducted in different universities with 218 geography teacher candidates enrolled in the geography education non-thesis master's degree…

  20. Features of parallel processing of Russian language content using the basic characteristics of object-oriented high-level programming languages

    Directory of Open Access Journals (Sweden)

    Дмитрий Евгеньевич Кошкин

    2013-12-01

    Full Text Available The article discusses the general features which are traceable in the Russian language and high-level programming languages, and offers an approach to identify the relationship between words in a sentence and proposals within the text. A matter may be interesting in terms of automatic semantic analysis of texts and for the systems of automatic translation.

  1. FORMING FUTURE ENGLISH TEACHERS’ LISTENING SKILLS VIA DRAMATIZATION

    Directory of Open Access Journals (Sweden)

    Olha Datskiv

    2016-12-01

    Full Text Available The article analyses the problem of forming future English teachers’ listening competence as an important component of future English teachers’ communicative competence. The requirements for future English teachers’ listening competence at the beginning stage of the university course have been determined. Dramatization has been considered as a means of forming future English teachers’ listening skills and it has been defined as interaction of a lecturer and students in drama games, role plays, improvisations, simulations and theatre projects aimed at forming the students’ communicative competence. The appropriateness of using different forms of dramatization for forming the second year students’ listening skills has been substantiated, the students’ listening skills have been determined. The complex of exercises for forming the students’ listening skills while learning the topic “Work and Employment” has been suggested. The structure of the complex has been outlined, the types and kinds of exercises have been described. The examples of exercises have been given. The exercises of the complex are aimed at simultaneous development of speaking, listening and writing skills of the future English teachers.

  2. Using dramatic role-play to develop emotional aptitude

    Directory of Open Access Journals (Sweden)

    Russell Dinapoli

    2009-12-01

    Full Text Available As university educators, we need to prepare students for the transition from the information age to what Daniel H. Pink (2005 calls the conceptual age, which is governed by artistry, empathy and emotion, by including in the curricula activities that stimulate both hemispheres of the brain. This can be done by promoting activities that energize what Daniel Goleman (1995 refers to as emotional intelligence, and it further maintains that, as Paul Ekman (2003 suggests, the ability to detect feelings improves communication. Recognizing the need to include in the curricula procedures that help develop students’ right brain aptitudes and enhance their communication skills, I have endeavoured to introduce dramatic scene study as a sustained activity in my English for Specific Purposes courses at the Universidad de Valencia. My aim was to energize the students’ creative and emotional aptitudes, as well as to dynamize effective teamwork. This article sustains that dramatic role-play, based on scripted scene study and related improvisational activities, is one way of achieving this.

  3. Burke’s Dramatism Framework: A Lens to Analyse Bullying

    Directory of Open Access Journals (Sweden)

    Lynette Jacobs

    2017-05-01

    Full Text Available Bullying is rife in schools across the world, which has emotional, educational as well as financial implications. Research suggests that the way in which bystanders, and in particular adults, react to such incidents is pivotal in curbing this problem. While a dearth of research focuses on the victims as well as the perpetrators of bullying, one should not ignore how different interactions between role-players influence the situation. The purpose of the paper is to explore the extent to which Burke’s Dramatism framework can be used as a lens to gain insight into how role-players respond to bullying incidences, and how this contributes to the drama. I use a series of email discussions with the mother of a bullied child as a case study.

  4. Media and identification processes: a ritual and dramatic construction

    Directory of Open Access Journals (Sweden)

    Salomé Sola-Morales

    2016-07-01

    Full Text Available The present theoretical paper analyzes the way mediatic communication construct identifications. The thesis proposed is that the media configure ritually and dramatically identifications made by individuals and groups. First of all, we show the limitations of the concept of “identity” and we propose to use “identification” instead. Second, we explore the extent of social drama theory and role theory and we open it to new theoretical challenges and perspectives. Thirdly, it is shown that the concept of "ritual" is very useful to understand and interpret the identity construction through the media. All this leads us to conclude that both the theatricality and rituality are key to understanding the processes of identification that individuals and groups make in relation to the media.

  5. PROMOTING INCIDENTAL VOCABULARY LEARNING THROUGH VERBAL DRAMATIZATION OF WORDS

    Directory of Open Access Journals (Sweden)

    Looi-Chin Ch’ng

    2014-12-01

    Full Text Available Despite the fact that explicit teaching of vocabulary is often practised in English as a Second Language (ESL classrooms, it has been proven to be rather ineffective, largely because words are not taught in context. This has prompted the increasing use of incidental vocabulary learning approach, which emphasises on repeated readings as a source for vocabulary learning. By adopting this approach, this study aims to investigate students’ ability in learning vocabulary incidentally via verbal dramatization of written texts. In this case, readers’ theatre (RT is used as a way to allow learners to engage in active reading so as to promote vocabulary learning. A total of 160 diploma students participated in this case study and they were divided equally into two groups, namely classroom reading (CR and RT groups. A proficiency test was first conducted to determine their vocabulary levels. Based on the test results, a story was selected as the reading material in the two groups. The CR group read the story through a normal reading lesson in class while the RT group was required to verbally dramatize the text through readers’ theatre activity. Then, a post-test based on vocabulary levels was carried out and the results were compared. The findings revealed that incidental learning was more apparent in the RT group and their ability to learn words from the higher levels was noticeable through higher accuracy scores. Although not conclusive, this study has demonstrated the potential of using readers’ theatre as a form of incidental vocabulary learning activity in ESL settings.

  6. Genetic Programming and Frequent Itemset Mining to Identify Feature Selection Patterns of iEEG and fMRI Epilepsy Data.

    Science.gov (United States)

    Smart, Otis; Burrell, Lauren

    2015-03-01

    Pattern classification for intracranial electroencephalogram (iEEG) and functional magnetic resonance imaging (fMRI) signals has furthered epilepsy research toward understanding the origin of epileptic seizures and localizing dysfunctional brain tissue for treatment. Prior research has demonstrated that implicitly selecting features with a genetic programming (GP) algorithm more effectively determined the proper features to discern biomarker and non-biomarker interictal iEEG and fMRI activity than conventional feature selection approaches. However for each the iEEG and fMRI modalities, it is still uncertain whether the stochastic properties of indirect feature selection with a GP yield (a) consistent results within a patient data set and (b) features that are specific or universal across multiple patient data sets. We examined the reproducibility of implicitly selecting features to classify interictal activity using a GP algorithm by performing several selection trials and subsequent frequent itemset mining (FIM) for separate iEEG and fMRI epilepsy patient data. We observed within-subject consistency and across-subject variability with some small similarity for selected features, indicating a clear need for patient-specific features and possible need for patient-specific feature selection or/and classification. For the fMRI, using nearest-neighbor classification and 30 GP generations, we obtained over 60% median sensitivity and over 60% median selectivity. For the iEEG, using nearest-neighbor classification and 30 GP generations, we obtained over 65% median sensitivity and over 65% median selectivity except one patient.

  7. Brain responses to language-relevant musical features in adolescent cochlear implant users before and after an intensive music training program

    DEFF Research Database (Denmark)

    Petersen, Bjørn; Weed, Ethan; Hansen, Mads

    Brain responses to language-relevant musical features in adolescent cochlear implant users before and after an intensive music training program Petersen B.1,2, Weed E.1,3, Hansen M.1,4, Sørensen S.D.3 , Sandmann P.5 , Vuust P.1,2 1Center of Functionally Integrative Neuroscience, Aarhus University...... musical training. The finding points toward the possibility of improving appreciation of music in general for adolescent CI users, and using music as a motivating element in speech therapy programs....

  8. Dramatically Enhanced Spin Dynamo with Plasmonic Diabolo Cavity.

    Science.gov (United States)

    Gou, Peng; Qian, Jie; Xi, Fuchun; Zou, Yuexin; Cao, Jun; Yu, Haochi; Zhao, Ziyi; Yang, Le; Xu, Jie; Wang, Hengliang; Zhang, Lijian; An, Zhenghua

    2017-07-13

    The applications of spin dynamos, which could potentially power complex nanoscopic devices, have so far been limited owing to their extremely low energy conversion efficiencies. Here, we present a unique plasmonic diabolo cavity (PDC) that dramatically improves the spin rectification signal (enhancement of more than three orders of magnitude) under microwave excitation; further, it enables an energy conversion efficiency of up to ~0.69 mV/mW, compared with ~0.27 μV/mW without a PDC. This remarkable improvement arises from the simultaneous enhancement of the microwave electric field (~13-fold) and the magnetic field (~195-fold), which cooperate in the spin precession process generates photovoltage (PV) efficiently under ferromagnetic resonance (FMR) conditions. The interplay of the microwave electromagnetic resonance and the ferromagnetic resonance originates from a hybridized mode based on the plasmonic resonance of the diabolo structure and Fabry-Perot-like modes in the PDC. Our work sheds light on how more efficient spin dynamo devices for practical applications could be realized and paves the way for future studies utilizing both artificial and natural magnetism for applications in many disciplines, such as for the design of future efficient wireless energy conversion devices, high frequent resonant spintronic devices, and magnonic metamaterials.

  9. Dramatically enhanced electrical breakdown strength in cellulose nanopaper

    Directory of Open Access Journals (Sweden)

    Jianwen Huang

    2016-09-01

    Full Text Available Electrical breakdown behaviors of nanopaper prepared from nanofibrillated cellulose (NFC were investigated. Compared to conventional insulating paper made from micro softwood fibers, nanopaper has a dramatically enhanced breakdown strength. Breakdown field of nanopaper is 67.7 kV/mm, whereas that of conventional paper is only 20 kV/mm. Air voids in the surface of conventional paper are observed by scanning electron microscope (SEM. Further analyses using mercury intrusion show that pore diameter of conventional paper is around 1.7 μm, while that of nanopaper is below 3 nm. Specific pore size of nanopaper is determined to be approximately 2.8 nm by the gas adsorption technique. In addition, theoretical breakdown strengths of nanopaper and conventional paper are also calculated to evaluate the effect of pore size. It turns out that theoretical values agree well with experimental data, indicating that the improved strength in nanopaper is mainly attributed to the decreased pore size. Due to its outstanding breakdown strength, this study indicates the suitability of nanopaper for electrical insulation in ultra-high voltage convert transformers and other electrical devices.

  10. Dramatically enhanced electrical breakdown strength in cellulose nanopaper

    Science.gov (United States)

    Huang, Jianwen; Zhou, Yuanxiang; Zhou, Zhongliu; Liu, Rui

    2016-09-01

    Electrical breakdown behaviors of nanopaper prepared from nanofibrillated cellulose (NFC) were investigated. Compared to conventional insulating paper made from micro softwood fibers, nanopaper has a dramatically enhanced breakdown strength. Breakdown field of nanopaper is 67.7 kV/mm, whereas that of conventional paper is only 20 kV/mm. Air voids in the surface of conventional paper are observed by scanning electron microscope (SEM). Further analyses using mercury intrusion show that pore diameter of conventional paper is around 1.7 μ m , while that of nanopaper is below 3 nm. Specific pore size of nanopaper is determined to be approximately 2.8 nm by the gas adsorption technique. In addition, theoretical breakdown strengths of nanopaper and conventional paper are also calculated to evaluate the effect of pore size. It turns out that theoretical values agree well with experimental data, indicating that the improved strength in nanopaper is mainly attributed to the decreased pore size. Due to its outstanding breakdown strength, this study indicates the suitability of nanopaper for electrical insulation in ultra-high voltage convert transformers and other electrical devices.

  11. PSYCHOLOGICAL FEATURES IN PATIENTS WITH CORONARY HEART DISEASE (MEN AND WOMEN PRIOR TO CORONARY ARTERY BYPASS GRAFTING DEPENDING ON THEIR INVOLVEMENT IN THE INDIVIDUAL PSYCHO-CORRECTION PROGRAM

    Directory of Open Access Journals (Sweden)

    D. A. Starunskaya

    2017-01-01

    Full Text Available Importance. The study of psychological characteristics of patients is important for the creation and planning of psychological correction and improve the efficiency of the treatment of coronary heart disease.Тhe purpose. This research is devoted to the study of the psychological features in patients with coronary artery disease (CHD in the preoperative period, depending on their involvement in psycho-correction program.Material and methods. We observed 30 patients with coronary heart disease before coronary bypass surgery. Clinical-psychological method (observation, conversation and psychological testing were used.Results  and conclusions. We found that patients who participated in psycho-correction program had lower values of «anxiety», «phobic anxiety» and «obsessive-compulsive» symptoms. In both groups of patients, on average, we identified the prevalence  of the coping-strategies «self-control» and «planning solution». Furthermore, on average, the «self-awareness» and «extraversion» were more manifested features in the structure of the personality traits of the surveyed patients. The revealed features should be taken into account in planning the programs of psycho-correction for patients with CHD prior to CABG surgery.

  12. Impacts on coralligenous outcrop biodiversity of a dramatic coastal storm.

    Directory of Open Access Journals (Sweden)

    Núria Teixidó

    Full Text Available Extreme events are rare, stochastic perturbations that can cause abrupt and dramatic ecological change within a short period of time relative to the lifespan of organisms. Studies over time provide exceptional opportunities to detect the effects of extreme climatic events and to measure their impacts by quantifying rates of change at population and community levels. In this study, we show how an extreme storm event affected the dynamics of benthic coralligenous outcrops in the NW Mediterranean Sea using data acquired before (2006-2008 and after the impact (2009-2010 at four different sites. Storms of comparable severity have been documented to occur occasionally within periods of 50 years in the Mediterranean Sea. We assessed the effects derived from the storm comparing changes in benthic community composition at sites exposed to and sheltered from this extreme event. The sites analyzed showed different damage from severe to negligible. The most exposed and impacted site experienced a major shift immediately after the storm, represented by changes in the species richness and beta diversity of benthic species. This site also showed higher compositional variability immediately after the storm and over the following year. The loss of cover of benthic species resulted between 22% and 58%. The damage across these species (e.g. calcareous algae, sponges, anthozoans, bryozoans, tunicates was uneven, and those with fragile forms were the most impacted, showing cover losses up to 50 to 100%. Interestingly, small patches survived after the storm and began to grow slightly during the following year. In contrast, sheltered sites showed no significant changes in all the studied parameters, indicating no variations due to the storm. This study provides new insights into the responses to large and rare extreme events of Mediterranean communities with low dynamics and long-lived species, which are among the most threatened by the effects of global change.

  13. Historical sampling reveals dramatic demographic changes in western gorilla populations

    Directory of Open Access Journals (Sweden)

    Guschanski Katerina

    2011-04-01

    Full Text Available Abstract Background Today many large mammals live in small, fragmented populations, but it is often unclear whether this subdivision is the result of long-term or recent events. Demographic modeling using genetic data can estimate changes in long-term population sizes while temporal sampling provides a way to compare genetic variation present today with that sampled in the past. In order to better understand the dynamics associated with the divergences of great ape populations, these analytical approaches were applied to western gorillas (Gorilla gorilla and in particular to the isolated and Critically Endangered Cross River gorilla subspecies (G. g. diehli. Results We used microsatellite genotypes from museum specimens and contemporary samples of Cross River gorillas to infer both the long-term and recent population history. We find that Cross River gorillas diverged from the ancestral western gorilla population ~17,800 years ago (95% HDI: 760, 63,245 years. However, gene flow ceased only ~420 years ago (95% HDI: 200, 16,256 years, followed by a bottleneck beginning ~320 years ago (95% HDI: 200, 2,825 years that caused a 60-fold decrease in the effective population size of Cross River gorillas. Direct comparison of heterozygosity estimates from museum and contemporary samples suggests a loss of genetic variation over the last 100 years. Conclusions The composite history of western gorillas could plausibly be explained by climatic oscillations inducing environmental changes in western equatorial Africa that would have allowed gorilla populations to expand over time but ultimately isolate the Cross River gorillas, which thereafter exhibited a dramatic population size reduction. The recent decrease in the Cross River population is accordingly most likely attributable to increasing anthropogenic pressure over the last several hundred years. Isolation of diverging populations with prolonged concomitant gene flow, but not secondary admixture, appears

  14. Historical sampling reveals dramatic demographic changes in western gorilla populations

    Science.gov (United States)

    2011-01-01

    Background Today many large mammals live in small, fragmented populations, but it is often unclear whether this subdivision is the result of long-term or recent events. Demographic modeling using genetic data can estimate changes in long-term population sizes while temporal sampling provides a way to compare genetic variation present today with that sampled in the past. In order to better understand the dynamics associated with the divergences of great ape populations, these analytical approaches were applied to western gorillas (Gorilla gorilla) and in particular to the isolated and Critically Endangered Cross River gorilla subspecies (G. g. diehli). Results We used microsatellite genotypes from museum specimens and contemporary samples of Cross River gorillas to infer both the long-term and recent population history. We find that Cross River gorillas diverged from the ancestral western gorilla population ~17,800 years ago (95% HDI: 760, 63,245 years). However, gene flow ceased only ~420 years ago (95% HDI: 200, 16,256 years), followed by a bottleneck beginning ~320 years ago (95% HDI: 200, 2,825 years) that caused a 60-fold decrease in the effective population size of Cross River gorillas. Direct comparison of heterozygosity estimates from museum and contemporary samples suggests a loss of genetic variation over the last 100 years. Conclusions The composite history of western gorillas could plausibly be explained by climatic oscillations inducing environmental changes in western equatorial Africa that would have allowed gorilla populations to expand over time but ultimately isolate the Cross River gorillas, which thereafter exhibited a dramatic population size reduction. The recent decrease in the Cross River population is accordingly most likely attributable to increasing anthropogenic pressure over the last several hundred years. Isolation of diverging populations with prolonged concomitant gene flow, but not secondary admixture, appears to be a typical

  15. Distinguishing carcinoid tumor from small cell carcinoma of the lung: correlating cytologic features and performance in the College of American Pathologists Non-Gynecologic Cytology Program.

    Science.gov (United States)

    Renshaw, Andrew A; Haja, Jennifer; Lozano, Richard L; Wilbur, David C

    2005-05-01

    The cytologic features of carcinoid tumor of the lung are well described. Nevertheless, some carcinoids may be difficult to distinguish from small cell carcinomas. To correlate the cytologic features of individual cases of carcinoid tumor of the lung in fine-needle aspiration specimens in the College of American Pathologists Non-Gynecologic Cytology Program with the frequency of misclassification as small cell carcinoma. We reviewed 1100 interpretations from 26 different cases of carcinoid tumor in lung fine-needle aspiration specimens in the College of American Pathologists Non-Gynecologic Cytology Program and correlated the cytologic features with the performance in the program. Cases were divided into those that were frequently misclassified as small cell carcinoma (at least 20% of the responses, 19 cases) and those that were infrequently misclassified as small cell carcinoma (cytologic features that might be responsible for misclassification as small cell carcinoma. All 7 cases that were infrequently misclassified consisted of numerous monotonous well-preserved tumor cells that were either entirely round or were a mixture of round and spindle-shaped cells. Six of 7 cases showed a prominent streaming vascular pattern with tumor cells attached to the endothelial cell core. In contrast, cases that were frequently misclassified had 1 of 6 patterns that were not seen in cases that were rarely misclassified. These 6 patterns were: (1) poorly preserved and pale-staining cells with fine chromatin and a suggestion of molding (5 cases); (2) numerous large, well-preserved, spindle-shaped cells (2 cases); (3) numerous cells varying markedly in both size and shape (both round and spindle-shaped cells), with a common finding of degenerated, smudgy, small round and spindle-shaped cells (9 cases); (4) hypocellular specimens (8 cases); (5) obscuration of cells by blood (2 cases); and (6) tumor cells present predominantly in groups, with few isolated cells (8 cases). In none of

  16. Dramatization as a Teaching Technique in Work Orientation.

    Science.gov (United States)

    Barcinas, Susan Jane; Gozar, Maria Dolores

    1986-01-01

    The benefits of using drama as a teaching technique became evident in the Work Orientation program at the Philippine Refugee Processing Center when a team of teachers presented two plays for their lower-level students. Students enjoyed the activity and were able to discuss work-related problems freely. As a result, the students' self esteem was…

  17. At the Zoo: Kindergartners Reinvent a Dramatic Play Area

    Science.gov (United States)

    Bowne, Mary; Brokmeier, Sue

    2008-01-01

    In a South Dakota early childhood program, children and adults in the kindergarten classroom collaborated to build a "classroom zoo" in support of the children's pretend play. Creation of the zoo incorporated information about animals and zoos that the children and their families and teachers located in secondary sources such as…

  18. Efficacy of standard versus enhanced features in a Web-based commercial weight-loss program for obese adults, part 2: randomized controlled trial.

    Science.gov (United States)

    Collins, Clare E; Morgan, Philip J; Hutchesson, Melinda J; Callister, Robin

    2013-07-22

    Commercial Web-based weight-loss programs are becoming more popular and increasingly refined through the addition of enhanced features, yet few randomized controlled trials (RCTs) have independently and rigorously evaluated the efficacy of these commercial programs or additional features. To determine whether overweight and obese adults randomized to an online weight-loss program with additional support features (enhanced) experienced a greater reduction in body mass index (BMI) and increased usage of program features after 12 and 24 weeks compared to those randomized to a standard online version (basic). An assessor-blinded RCT comparing 301 adults (male: n=125, 41.5%; mean age: 41.9 years, SD 10.2; mean BMI: 32.2 kg/m(2), SD 3.9) who were recruited and enrolled offline, and randomly allocated to basic or enhanced versions of a commercially available Web-based weight-loss program for 24 weeks. Retention at 24 weeks was greater in the enhanced group versus the basic group (basic 68.5%, enhanced 81.0%; P=.01). In the intention-to-treat analysis of covariance with imputation using last observation carried forward, after 24 weeks both intervention groups had reductions in key outcomes with no difference between groups: BMI (basic mean -1.1 kg/m(2), SD 1.5; enhanced mean -1.3 kg/m(2), SD 2.0; P=.29), weight (basic mean -3.3 kg, SD 4.7; enhanced mean -4.0 kg, SD 6.2; P=.27), waist circumference (basic mean -3.1 cm, SD 4.6; enhanced mean -4.0 cm, SD 6.2; P=.15), and waist-to-height ratio (basic mean -0.02, SD 0.03; enhanced mean -0.02, SD 0.04, P=.21). The enhanced group logged in more often at both 12 and 24 weeks, respectively (enhanced 12-week mean 34.1, SD 28.1 and 24-week mean 43.1, SD 34.0 vs basic 12-week mean 24.6, SD 25.5 and 24-week mean 31.8, SD 33.9; P=.002). The addition of personalized e-feedback in the enhanced program provided limited additional benefits compared to a standard commercial Web-based weight-loss program. However, it does support greater

  19. A 12-week commercial web-based weight-loss program for overweight and obese adults: randomized controlled trial comparing basic versus enhanced features.

    Science.gov (United States)

    Collins, Clare E; Morgan, Philip J; Jones, Penelope; Fletcher, Kate; Martin, Julia; Aguiar, Elroy J; Lucas, Ashlee; Neve, Melinda J; Callister, Robin

    2012-04-25

    The development and use of Web-based programs for weight loss is increasing rapidly, yet they have rarely been evaluated using randomized controlled trials (RCTs). Interestingly, most people who attempt weight loss use commercially available programs, yet it is very uncommon for commercial programs to be evaluated independently or rigorously. To compare the efficacy of a standard commercial Web-based weight-loss program (basic) versus an enhanced version of this Web program that provided additional personalized e-feedback and contact from the provider (enhanced) versus a wait-list control group (control) on weight outcomes in overweight and obese adults. This purely Web-based trial using a closed online user group was an assessor-blinded RCT with participants randomly allocated to the basic or enhanced 12-week Web-based program, based on social cognitive theory, or the control, with body mass index (BMI) as the primary outcome. We enrolled 309 adults (129/309, 41.8% male, BMI mean 32.3, SD 4 kg/m(2)) with 84.1% (260/309) retention at 12 weeks. Intention-to-treat analysis showed that both intervention groups reduced their BMI compared with the controls (basic: -0.72, SD 1.1 kg/m(2), enhanced: -1.0, SD 1.4, control: 0.15, SD 0.82; P Web-based weight-loss program can be efficacious across a range of weight-related outcomes and lifestyle behaviors and achieve clinically important weight loss. Although the provision of additional personalized feedback did not facilitate greater weight loss after 12 weeks, the impact of superior participant retention on longer-term outcomes requires further study. Further research is required to determine the optimal mix of program features that lead to the biggest treatment impact over time. Australian New Zealand Clinical Trials Registry (ANZCTR): 12610000197033.

  20. A Study in Speech Recognition Using a Kohonen Neural Network Dynamic Programming and Multi-Feature Fusion

    Science.gov (United States)

    1989-12-01

    FEATURE FUSION THESIS Presented to the Faculty of the School of Engineering of the Air Force Institute of Technology Air University In Partial...years of schooling . Because of her sacrifice and understanding, I was able to fulfill many personal dreams. Wayne F. Recla AossionFo TIS GRA&f’- DTIC...where: 42 LINEAR / EXPONENTIAL Example Gain Graph Gaia Value 0.1 0.08 0.04 0.02 S󈧎 20 30 40 80 so 70 so 90 100 Training Iterations (x 1000) - Linea

  1. Behavioral and Neurological Responses to Musical Features in Adolescent Cochlear Implant Users Before and After an Intensive Musical Training Program

    DEFF Research Database (Denmark)

    Petersen, Bjørn

    This study aimed to investigate perception and processing of musical features in prelingually deaf adolescent CI-users and examine whether this is influenced by music training. Eleven adolescent CI-users received intensive music training for two weeks. Before and after training they completed...... responses for timbre, intensity and rhythm but not for pitch. No effect of training was found in the MMN responses. The findings indicate that despite congenital deafness and late implantation, young CI users are able to discriminate details in music. Furthermore, the behavioral advances suggest that......, in a wider perspective, music training may serve as a supplementary measure of rehabilitation....

  2. Dramatic Change in Jupiter's Great Red Spot from Spacecraft Observations

    Science.gov (United States)

    Simon, Amy A.; Wong, Michael H.; Rogers, John H.; Orton, Glenn S.; de Pater, Imke; Asay-Davis, Xylar; Carlson, Robert W.; Marcus, Philip S.

    2015-01-01

    Jupiter's Great Red Spot (GRS) is one of its most distinct and enduring features. Since the advent of modern telescopes, keen observers have noted its appearance and documented a change in shape from very oblong to oval, confirmed in measurements from spacecraft data. It currently spans the smallest latitude and longitude size ever recorded. Here we show that this change has been accompanied by an increase in cloud/haze reflectance as sensed in methane gas absorption bands, increased absorption at wavelengths shorter than 500 nanometers, and increased spectral slope between 500 and 630 nanometers. These changes occurred between 2012 and 2014, without a significant change in internal tangential wind speeds; the decreased size results in a 3.2 day horizontal cloud circulation period, shorter than previously observed. As the GRS has narrowed in latitude, it interacts less with the jets flanking its north and south edges, perhaps allowing for less cloud mixing and longer UV irradiation of cloud and aerosol particles. Given its long life and observational record, we expect that future modeling of the GRS's changes, in concert with laboratory flow experiments, will drive our understanding of vortex evolution and stability in a confined flow field crucial for comparison with other planetary atmospheres.

  3. A Reading Skills Development Program for Adult Non-Readers. Featuring: Supplementary Graphics and Sound (Voice Tutorials). Volumes 1 and 2. The TRS-80 Computer Assisted Instruction Series for Adult Basic Education Students.

    Science.gov (United States)

    San Antonio State Hospital, TX. Office of Education Services.

    This instructional manual consists of materials for use in implementing a computer-assisted instructional program in reading skills development for adult nonreaders. Discussed first are the project during which this instructional program and manual were developed and the goals of the computer-assisted beginning reading program, a major feature of…

  4. World-Wide Effort Produces Dramatic "Movie" of Cosmic Jet

    Science.gov (United States)

    2001-05-01

    Astronomers using a world-wide collection of radio telescopes, including the National Science Foundation's Very Long Baseline Array (VLBA) of the National Radio Astronomy Observatory (NRAO), have made a dramatic "movie" of a voracious, superdense neutron star repeatedly spitting out subatomic particles at nearly the speed of light into two narrow jets as it pulls material from a companion star. The movie shows these jets ejecting clouds of hot plasma that are then "zapped" by pulses of energy in the jets as they move away from the neutron star. Frame from Radio-Telescope 'Movie' of Scorpius X-1 "We have directly measured the speed of energy flow in a cosmic jet for the first time," said Ed Fomalont, an astronomer at the NRAO in Charlottesville, Virginia. Fomalont worked with Barry Geldzahler and Charles Bradshaw of George Mason University in Fairfax, Virginia. The astronomers used the VLBA, the NSF's Very Large Array (VLA) and the Green Bank 140-foot telescope, along with radio telescopes from the European VLBI Network, Australia, Japan and South Africa to record the double-star system's eruptions continuously for 56 hours. "This study is going to be extremely valuable in helping us understand a phenomenon that we see throughout the universe," Fomalont said. Cosmic jets of superfast particles are ejected from the cores of numerous galaxies. On a smaller scale, similar jets are ejected from binary-star systems closer to home, in our own Milky Way Galaxy. While the jets from galaxy cores are thought to be powered by supermassive black holes millions of times more massive than the Sun, the closer "microquasars" are powered by much smaller black holes or by neutron stars only a few times more massive than the sun. "Studying one of the closer, smaller examples will help us understand how they all work, including the bigger ones," Geldzahler said. "The jets coming from distant galaxies are harder to study because of their much greater distance and the slowness of their

  5. Special test results evaluation features as development of “Innovations management” program - NEFU testing area as case-study

    Science.gov (United States)

    Ermakov, A. V.; Bessmertnyy, A. M.

    2017-10-01

    This article gives an overview on the problems of precision in the results evaluation of the tests carried out in the Northern testing areas. One of the significant features of the facilities under study is that they are limited in quantity. In cases when a facility is taken down, that quantity is normally equal to one. The complexity of modern technological equipment and other circumstances require researchers to take into account and evaluate the potential risks. In order to make the sought-for estimations more precise, ways of improving the test result evaluations algorithms are suggested. In particular, one of the productive methods is the Data Mining technology, which presupposes implementing an intellectual analysis of the data with the aim of extracting useful information from the available database which was attained during the tests and other types of activities. Applying the Data Mining technology is becoming more productive when the scenario analysis is carried out, i.e., the analysis of possible alternative solutions. Another perspective trend is an implementation of an interdisciplinary approach. As a result, researchers are able to carry out a complex evaluation of the test results, which will noticeably increase the value of the given results.

  6. A 12-Week Commercial Web-Based Weight-Loss Program for Overweight and Obese Adults: Randomized Controlled Trial Comparing Basic Versus Enhanced Features

    Science.gov (United States)

    Morgan, Philip J; Jones, Penelope; Fletcher, Kate; Martin, Julia; Aguiar, Elroy J; Lucas, Ashlee; Neve, Melinda J; Callister, Robin

    2012-01-01

    Background The development and use of Web-based programs for weight loss is increasing rapidly, yet they have rarely been evaluated using randomized controlled trials (RCTs). Interestingly, most people who attempt weight loss use commercially available programs, yet it is very uncommon for commercial programs to be evaluated independently or rigorously. Objective To compare the efficacy of a standard commercial Web-based weight-loss program (basic) versus an enhanced version of this Web program that provided additional personalized e-feedback and contact from the provider (enhanced) versus a wait-list control group (control) on weight outcomes in overweight and obese adults. Methods This purely Web-based trial using a closed online user group was an assessor-blinded RCT with participants randomly allocated to the basic or enhanced 12-week Web-based program, based on social cognitive theory, or the control, with body mass index (BMI) as the primary outcome. Results We enrolled 309 adults (129/309, 41.8% male, BMI mean 32.3, SD 4 kg/m2) with 84.1% (260/309) retention at 12 weeks. Intention-to-treat analysis showed that both intervention groups reduced their BMI compared with the controls (basic: –0.72, SD 1.1 kg/m2, enhanced: –1.0, SD 1.4, control: 0.15, SD 0.82; P 3.0, SD 4.1, control: 0.4, SD 2.3; P 2.0, SD 3.5 cm, enhanced: –3.2, SD 4.7, control: 0.5, SD 3.0; P Web-based weight-loss program can be efficacious across a range of weight-related outcomes and lifestyle behaviors and achieve clinically important weight loss. Although the provision of additional personalized feedback did not facilitate greater weight loss after 12 weeks, the impact of superior participant retention on longer-term outcomes requires further study. Further research is required to determine the optimal mix of program features that lead to the biggest treatment impact over time. Trial Registration Australian New Zealand Clinical Trials Registry (ANZCTR): 12610000197033; http

  7. Strategic partnering to improve community health worker programming and performance: features of a community-health system integrated approach.

    Science.gov (United States)

    Naimoli, Joseph F; Perry, Henry B; Townsend, John W; Frymus, Diana E; McCaffery, James A

    2015-09-01

    There is robust evidence that community health workers (CHWs) in low- and middle-income (LMIC) countries can improve their clients' health and well-being. The evidence on proven strategies to enhance and sustain CHW performance at scale, however, is limited. Nevertheless, CHW stakeholders need guidance and new ideas, which can emerge from the recognition that CHWs function at the intersection of two dynamic, overlapping systems - the formal health system and the community. Although each typically supports CHWs, their support is not necessarily strategic, collaborative or coordinated. We explore a strategic community health system partnership as one approach to improving CHW programming and performance in countries with or intending to mount large-scale CHW programmes. To identify the components of the approach, we drew on a year-long evidence synthesis exercise on CHW performance, synthesis records, author consultations, documentation on large-scale CHW programmes published after the synthesis and other relevant literature. We also established inclusion and exclusion criteria for the components we considered. We examined as well the challenges and opportunities associated with implementing each component. We identified a minimum package of four strategies that provide opportunities for increased cooperation between communities and health systems and address traditional weaknesses in large-scale CHW programmes, and for which implementation is feasible at sub-national levels over large geographic areas and among vulnerable populations in the greatest need of care. We postulate that the CHW performance benefits resulting from the simultaneous implementation of all four strategies could outweigh those that either the health system or community could produce independently. The strategies are (1) joint ownership and design of CHW programmes, (2) collaborative supervision and constructive feedback, (3) a balanced package of incentives, and (4) a practical monitoring

  8. Dramatization at Extracurricular Activities as a Means to Enhance Foreign Language Teaching

    Directory of Open Access Journals (Sweden)

    Marina Valeryevna Kuimova

    2015-02-01

    Full Text Available The main purpose of foreign language teaching is to learn to communicate and overcome the language barrier. The article studies dramatization and its appropriateness in foreign language teaching, provides criteria for choosing a literary work for dramatization. The use of dramatization at extracurricular activities develops communication abilities, creativity; enhances motivation to learn a foreign language and strengthens students’ confidence in a foreign language.

  9. Analysing the development of TV news programmes: from information to dramatization

    Directory of Open Access Journals (Sweden)

    Maribel Rodríguez Fidalgo, Ph.D.

    2010-01-01

    Full Text Available Abstract: The TV news programme is the backbone of all television networks, be they national, regional or local. These types of programmes have been changing over the time. The essence of the information is being modified and has adopted a new format. Based on these principles, this research analyses the evolution of the language used on the Spanish TV news programmes, from their origins until today. This research has been carried out in three different phases: late 1980s, the 1990s and recent years. These stages were thoroughly examined through surveys applied to representative samples of the population. The results showed that TV news programmes have been acquiring a changing narrative style throughout time: they began using an “objective” narrative, followed by a mediated type, and finally dramatized narrative which uses shocking visual content and aims to achieve audience’s sensibilization and identification with news’ protagonists. The spectacularization of information has become the identitary feature of the current TV news programmes as a response to the need of reaching higher audience ratings.

  10. The Impact of Dramatic Play Centre on Promoting the Development of Children's Early Writing Skills

    Science.gov (United States)

    Ihmeideh, Fathi

    2015-01-01

    The purpose of this study is to examine the impact of dramatic play centre (DPC) on promoting the development of children's early writing skills in the Jordanian context. It also intends to investigate the forms of children's writing skills that emerge through the use of dramatic play. Observations and interviews were conducted to obtain…

  11. "I Did Not Wash My Feet with that Woman": Using Dramatic Performance to Teach Biblical Studies

    Science.gov (United States)

    Torbett, David

    2010-01-01

    The student dramatic performance is an effective way for undergraduates to learn biblical studies. In this article I will give an example of a dramatic performance assignment that I developed over a number of courses and used most recently and most successfully in an undergraduate course in the Hebrew Bible at a small liberal arts college in the…

  12. SAFETY IMPROVES DRAMATICALLY IN FLUOR HANFORD SOIL AND GROUNDWATER REMEDIATION PROJECT

    Energy Technology Data Exchange (ETDEWEB)

    GERBER MS

    2007-12-05

    This paper describes dramatic improvements in the safety record of the Soil and Groundwater Remediation Project (SGRP) at the Hanford Site in southeast Washington state over the past four years. During a period of enormous growth in project work and scope, contractor Fluor Hanford reduced injuries, accidents, and other safety-related incidents and enhanced a safety culture that earned the SGRP Star Status in the Department of Energy's (DOE's) Voluntary Protection Program (VPP) in 2007. This paper outlines the complex and multi-faceted work of Fluor Hanford's SGRP and details the steps taken by the project's Field Operations and Safety organizations to improve safety. Holding field safety meetings and walkdowns, broadening safety inspections, organizing employee safety councils, intensively flowing down safety requirements to subcontractors, and adopting other methods to achieve remarkable improvement in safety are discussed. The roles of management, labor and subcontractors are detailed. Finally, SGRP's safety improvements are discussed within the context of overall safety enhancements made by Fluor Hanford in the company's 11 years of managing nuclear waste cleanup at the Hanford Site.

  13. {sup 18}F-FDG PET/CT heterogeneity quantification through textural features in the era of harmonisation programs: a focus on lung cancer

    Energy Technology Data Exchange (ETDEWEB)

    Lasnon, Charline [University Hospital, Nuclear Medicine Department, Caen (France); Biologie et Therapies Innovantes des Cancers Localement Agressifs, Universite de Caen Normandie, INSERM, Caen (France); Normandie University, Caen (France); Majdoub, Mohamed; Lavigne, Brice; Visvikis, Dimitris [LaTIM, INSERM UMR 1101, Brest (France); Do, Pascal [Thoracic Oncology, Francois Baclesse Cancer Centre, Caen (France); Madelaine, Jeannick [Caen University Hospital, Pulmonology Department, Caen (France); Hatt, Mathieu [LaTIM, INSERM UMR 1101, Brest (France); CHRU Morvan, INSERM UMR 1101, Laboratoire de Traitement de l' Information Medicale (LaTIM), Groupe ' Imagerie multi-modalite quantitative pour le diagnostic et la therapie' , Brest (France); Aide, Nicolas [University Hospital, Nuclear Medicine Department, Caen (France); Biologie et Therapies Innovantes des Cancers Localement Agressifs, Universite de Caen Normandie, INSERM, Caen (France); Normandie University, Caen (France); Caen University Hospital, Nuclear Medicine Department, Caen (France)

    2016-12-15

    Quantification of tumour heterogeneity in PET images has recently gained interest, but has been shown to be dependent on image reconstruction. This study aimed to evaluate the impact of the EANM/EARL accreditation program on selected {sup 18}F-FDG heterogeneity metrics. To carry out our study, we prospectively analysed 71 tumours in 60 biopsy-proven lung cancer patient acquisitions reconstructed with unfiltered point spread function (PSF) positron emission tomography (PET) images (optimised for diagnostic purposes), PSF-reconstructed images with a 7-mm Gaussian filter (PSF{sub 7}) chosen to meet European Association of Nuclear Medicine (EANM) 1.0 harmonising standards, and EANM Research Ltd. (EARL)-compliant ordered subset expectation maximisation (OSEM) images. Delineation was performed with fuzzy locally adaptive Bayesian (FLAB) algorithm on PSF images and reported on PSF{sub 7} and OSEM ones, and with a 50 % standardised uptake values (SUV){sub max} threshold (SUV{sub max50%}) applied independently to each image. Robust and repeatable heterogeneity metrics including 1st-order [area under the curve of the cumulative histogram (CH{sub AUC})], 2nd-order (entropy, correlation, and dissimilarity), and 3rd-order [high-intensity larger area emphasis (HILAE) and zone percentage (ZP)] textural features (TF) were statistically compared. Volumes obtained with SUV{sub max50%} were significantly smaller than FLAB-derived ones, and were significantly smaller in PSF images compared to OSEM and PSF{sub 7} images. PSF-reconstructed images showed significantly higher SUVmax and SUVmean values, as well as heterogeneity for CH{sub AUC}, dissimilarity, correlation, and HILAE, and a wider range of heterogeneity values than OSEM images for most of the metrics considered, especially when analysing larger tumours. Histological subtypes had no impact on TF distribution. No significant difference was observed between any of the considered metrics (SUV or heterogeneity features) that we

  14. Exploring Lyric, Epic, and Dramatic Voices: Stages of Incandescence in the Poetry of the Aged.

    Science.gov (United States)

    Reed, M. Ann

    1992-01-01

    Identifies true relationships between the psyche and the lyric, epic, and dramatic voices of poetry. Shows how the acts of identifying, responding to, and composing in these three voices engage healing, inspiration, and active imagination among the aging. (SR)

  15. Solar Features

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Collection includes a variety of solar feature datasets contributed by a number of national and private solar observatories located worldwide.

  16. Site Features

    Data.gov (United States)

    U.S. Environmental Protection Agency — This dataset consists of various site features from multiple Superfund sites in U.S. EPA Region 8. These data were acquired from multiple sources at different times...

  17. Feature Extraction

    CERN Multimedia

    CERN. Geneva

    2015-01-01

    Feature selection and reduction are key to robust multivariate analyses. In this talk I will focus on pros and cons of various variable selection methods and focus on those that are most relevant in the context of HEP.

  18. A dramatic, objective antiandrogen withdrawal response: case report and review of the literature

    Directory of Open Access Journals (Sweden)

    Litwin Alan

    2008-11-01

    Full Text Available Abstract Antiandrogen withdrawal response is an increasingly recognized entity in patients with metastatic prostate cancer. To our knowledge, there have been no reports describing a durable radiologic improvement along with prostate-specific antigen (PSA with discontinuation of the antiandrogen agent bicalutamide. We report a case in which a dramatic decline of serum PSA levels associated with a dramatic improvement in radiologic disease was achieved with bicalutamide discontinuation.

  19. Educational value of dramatization approach for development of dialogue speaking skills

    OpenAIRE

    Vanina, I.; Kravtsova, E.

    2014-01-01

    This study analyzes dramatization as a methodical approach at the foreign language lessons. Educational value of this approach is very high because it helps first of all to overcome a "language divide" and to improve motivation; also it inspires students of non-language higher education institutions to use a foreign language for solving some problems in their future professional area. The main components of dramatization are communicative situation, social roles and opportunity to use social ...

  20. Modeling attitude towards drug treament: the role of internal motivation, external pressure, and dramatic relief.

    Science.gov (United States)

    Conner, Bradley T; Longshore, Douglas; Anglin, M Douglas

    2009-04-01

    Motivation for change has historically been viewed as the crucial element affecting responsiveness to drug treatment. Various external pressures, such as legal coercion, may engender motivation in an individual previously resistant to change. Dramatic relief may be the change process that is most salient as individuals internalize such external pressures. Results of structural equation modeling on data from 465 drug users (58.9% male; 21.3% Black, 34.2% Hispanic/Latino, and 35.1% White) entering drug treatment indicated that internal motivation and external pressure significantly and positively predicted dramatic relief and that dramatic relief significantly predicted attitudes towards drug treatment: chi (2) = 142.20, df = 100, p motivation are high, dramatic relief is also likely to be high. When dramatic relief is high, attitudes towards drug treatment are likely to be positive. The findings indicate that interventions to get individuals into drug treatment should include processes that promote Dramatic Relief. Implications for addictions health services are discussed.

  1. High-Resolution Studies of Oceanic Spreading Center Volcanic and Hydrothermal Features and Processes - New Insights from Ridge 2000 Program Experiments

    Science.gov (United States)

    Fornari, D. J.

    2011-12-01

    During the past 60 years of research on mid-ocean ridges (MORs) we have exponentially increased our understandings one of the planet's most fundamental features and the myriad processes associated with the transfer of energy from the mantle to the hydrosphere that is focused along accretionary plate boundaries. The past decade's research, implemented by a broad community of scientists in numerous disciplines has yielded a watershed of information that has helped to make both temporal and spatial connections between processes that store and deliver magma to the crust and seafloor, and the consequent hydrothermal and biological phenomena that derive from that energy transfer. Ridge 2000 Program research at each of the three Integrated Study Sites (ISSs) - East Pacific Rise 8-10N, Juan de Fuca - Endeavour Segment, and Eastern Lau Spreading Center - provided an opportunity to coordinate field experiments, laboratory studies and modeling that has lead to new concepts of oceanic spreading center processes. In particular, the latest generation of near-bottom seafloor mapping and sampling systems and a new array of deep submergence vehicles, which include remotely operated vehicles (ROVs) and autonomous underwater vehicles (AUVs), as well more traditional human occupied vehicles (HOVs) like Alvin, have yielded important new views of MOR seafloor. These systems have allowed us to resolve the sub-meter topography of specific volcanic and hydrothermal features and relate them to distributions of hydrothermal communities, chemical variations among hydrothermal chimneys and their fluid effluent, and to axial structures that are surface manifestations of tectonic processes. In situ chemical, biological and microbial studies carried out during the past decade have increasingly shown how tightly linked chemical and biological processes are within MOR hydrothermal communities. Previous hypotheses concerning frequency of magmatism and volcanic eruptions that have related

  2. Object localization using adaptive feature selection

    Science.gov (United States)

    Hwang, S. Youngkyoo; Kim, Jungbae; Lee, Seongdeok

    2009-01-01

    'Fast and robust' are the most beautiful keywords in computer vision. Unfortunately they are in trade-off relationship. We present a method to have one's cake and eat it using adaptive feature selections. Our chief insight is that it compares reference patterns to query patterns, so that it selects smartly more important and useful features to find target. The probabilities of pixels in the query to belong to the target are calculated from importancy of features. Our framework has three distinct advantages: 1 - It saves computational cost dramatically to the conventional approach. This framework makes it possible to find location of an object in real-time. 2 - It can smartly select robust features of a reference pattern as adapting to a query pattern. 3- It has high flexibility on any feature. It doesn't matter which feature you may use. Lots of color space, texture, motion features and other features can fit perfectly only if the features meet histogram criteria.

  3. Dramatic pretend play games uniquely improve emotional control in young children.

    Science.gov (United States)

    Goldstein, Thalia R; Lerner, Matthew D

    2017-09-15

    Pretense is a naturally occurring, apparently universal activity for typically developing children. Yet its function and effects remain unclear. One theorized possibility is that pretense activities, such as dramatic pretend play games, are a possible causal path to improve children's emotional development. Social and emotional skills, particularly emotional control, are critically important for social development, as well as academic performance and later life success. However, the study of such approaches has been criticized for potential bias and lack of rigor, precluding the ability to make strong causal claims. We conducted a randomized, component control (dismantling) trial of dramatic pretend play games with a low-SES group of 4-year-old children (N = 97) to test whether such practice yields generalized improvements in multiple social and emotional outcomes. We found specific effects of dramatic play games only on emotional self-control. Results suggest that dramatic pretend play games involving physicalizing emotional states and traits, pretending to be animals and human characters, and engaging in pretend scenarios in a small group may improve children's emotional control. These findings have implications for the function of pretense and design of interventions to improve emotional control in typical and atypical populations. Further, they provide support for the unique role of dramatic pretend play games for young children, particularly those from low-income backgrounds. A video abstract of this article can be viewed at: https://youtu.be/2GVNcWKRHPk. © 2017 John Wiley & Sons Ltd.

  4. The Accessibility of Socio-Dramatic Play to Culturally and Linguistically Diverse Australian Preschoolers

    Science.gov (United States)

    Scrafton, Eleanor; Whitington, Victoria

    2015-01-01

    Socio-dramatic play is preschool children's leading learning activity (Karpov 2005; Vygotsky 1978). Yet entering play often poses challenges (Corsaro 2003), particularly for culturally and linguistically diverse (CALD) children (Hruska 2007). At preschool four-year-old CALD children are both acquiring a new language, and learning new rules, social…

  5. Dramatic colour changes in a bird of paradise caused by uniquely structured breast feather barbules

    NARCIS (Netherlands)

    Stavenga, Doekele G.; Leertouwer, Hein L.; Marshall, N. Justin; Osorio, Daniel

    2011-01-01

    The breast-plate plumage of male Lawes' parotia (Parotia lawesii) produces dramatic colour changes when this bird of paradise displays on its forest-floor lek. We show that this effect is achieved not solely by the iridescence-that is an angular-dependent spectral shift of the reflected light-which

  6. The Effect of Dramatized Instruction on Speaking Ability of Imam Ali University EFL Learners

    Directory of Open Access Journals (Sweden)

    Sadegh Khosronejad

    2013-09-01

    Full Text Available Teaching language as a second or foreign language, undoubtedly, is so demanding and seeking to find methods for facilitating this prominent practice whets the appetite of any practitioner who works in this field. Research shows that using drama in the classroom as a means of teaching helps students learn socially, academically, and developmentally. This study was an attempt to determine the effect of dramatized instruction on the speaking ability of EFL learners of Imam Ali University. Sixty EFL male students at the intermediate level participated in the study. Their age range was 19-22. Two instruments were utilized in this study; pretest, and posttest.  The data were analyzed through t-test. The data analysis indicated that the mean scores of the experimental group students (M = 72.80 were significantly different (3.29>2; df = 58 from the control group students (M = 65.39. In other words, the experimental group outperformed the control group in the posttest significantly. Moreover, the findings indicated that dramatized instruction does have a great effect on the speaking skills. This study supported the idea of effectiveness of dramatized instruction on developing speaking skill and the teachers can help the learners at lower levels promote their speaking skill through dramatized instruction in EFL classes.

  7. "Every word doth almost tell my name": Ambiguity, Authority, and Authenticity in Shakespeare's Dramatic Letters

    National Research Council Canada - National Science Library

    Bolton, Matthew

    2011-01-01

    .... Naturally, this sensitivity to social hierarchy is reflected in the drama of the period. An understanding of the performative nature of social class in the off-stage world is evident in dramatic costuming records that catalogue the clothing and props used to indicate the social positions of characters, and a quick scan of any few pages of Shakespe...

  8. Dramatic Declines in Higher Education Appropriations: State Conditions for Budget Punctuations

    Science.gov (United States)

    Li, Amy Y.

    2017-01-01

    Public colleges and universities depend heavily on state appropriations and legislatures must decide how much to fund higher education. This study applies punctuated equilibrium theory to characterize the distribution of annual changes in higher education appropriations and defines the threshold for a dramatic budget cut. Using data for the 50…

  9. How to Know when Dramatic Change Is on Track: Leading Indicators of School Turnarounds

    Science.gov (United States)

    Kowal, Julie; Ableidinger, Joe

    2011-01-01

    In recent years, national policymakers have placed new emphasis on "school turnarounds" as a strategy for rapid, dramatic improvement in chronically failing schools, calling on education leaders to turn around performance in the 5,000 lowest-achieving schools nationwide. This goal may seem daunting, given the dismal success rates of…

  10. Erotic Language as Dramatic Action in Plays by Lyly and Shakespeare

    Science.gov (United States)

    Knoll, Gillian

    2012-01-01

    This study closely examines the language of desire in the dramatic works of John Lyly and William Shakespeare, and argues that contemplative and analytical speeches about desire function as modes of action in their plays. Erotic speeches do more than express desire in a purely descriptive or perlocutionary capacity distinct from the action of the…

  11. Design and Implementation of Dramatic Tasks in an English for Academic Purposes Programme

    Science.gov (United States)

    Carson, Lorna; Murphy, Deirdre

    2012-01-01

    Task-based language learning involves the use of authentic tasks with a coherent process and concrete product as a means of planning, delivering and assessing a curriculum. In this article, we draw on our recent use of the descriptive apparatus of the "Common European Framework of Reference" (CEFR) to define and specify a dramatic task…

  12. Becoming Warriors: Dramatic Inquiry with 11- to 12-Year-Olds in an EBD Classroom

    Science.gov (United States)

    Edmiston, Brian; Sobjack, Laura

    2017-01-01

    Using a dialogue format, a college professor and a teacher of 11- to 12-year-old children with emotional and behavioural difficulties (EBD) report on a case study of four children (three boys and a girl) when over a three-week period dramatic inquiry pedagogy (focused on the meaning for students of fictional violent events depicted in extracts…

  13. Athenian and Shakespearean Tragedies in Oceania: Teaching Dramatic Literatures in Fiji

    Science.gov (United States)

    Anae, Nicole

    2013-01-01

    This paper presents a theorised classroom-based narrative discussing the author's interdisciplinary approach to the teaching of English dramatic literatures--in particular, Sophocles' "Oedipus the King" and Shakespeare's "Macbeth"--to i-Taukei, Indo-Fijian and Pacific Islander tertiary students at a South Pacific university.…

  14. Art-House Cinema, Avant-Garde Film, and Dramatic Modernism

    Science.gov (United States)

    Cardullo, Bert

    2011-01-01

    In this article, the author talks about art-house cinema, avant-garde film, and dramatic modernism. He believes that the most important modes of film practice are art-house cinema and the avant-garde, both of which contrast with the classical Hollywood mode of film practice. While the latter is characterized by its commercial imperative, corporate…

  15. Lord Kelvin and the Age-of-the-Earth Debate: A Dramatization.

    Science.gov (United States)

    Stinner, Art; Tecihman, Jurgen

    2003-01-01

    Presents a dramatization of a fictitious debate about the age of the earth that takes place at the Royal Institution, London, England, in the year 1872 among Sir William Thomson, T.H. Huxley, Sir Charles Lyell, and Hermann von Helmholtz. (Contains 17 references.) (Author/YDS)

  16. Featuring animacy

    Directory of Open Access Journals (Sweden)

    Elizabeth Ritter

    2015-01-01

    Full Text Available Algonquian languages are famous for their animacy-based grammatical properties—an animacy based noun classification system and direct/inverse system which gives rise to animacy hierarchy effects in the determination of verb agreement. In this paper I provide new evidence for the proposal that the distinctive properties of these languages is due to the use of participant-based features, rather than spatio-temporal ones, for both nominal and verbal functional categories (Ritter & Wiltschko 2009, 2014. Building on Wiltschko (2012, I develop a formal treatment of the Blackfoot aspectual system that assumes a category Inner Aspect (cf. MacDonald 2008, Travis 1991, 2010. Focusing on lexical aspect in Blackfoot, I demonstrate that the classification of both nouns (Seinsarten and verbs (Aktionsarten is based on animacy, rather than boundedness, resulting in a strikingly different aspectual system for both categories. 

  17. Disruption of M-T5, a novel myxoma virus gene member of poxvirus host range superfamily, results in dramatic attenuation of myxomatosis in infected European rabbits.

    Science.gov (United States)

    Mossman, K; Lee, S F; Barry, M; Boshkov, L; McFadden, G

    1996-07-01

    Myxoma virus is a pathogenic poxvirus that induces a lethal myxomatosis disease profile in European rabbits, which is characterized by fulminating lesions at the primary site of inoculation, rapid dissemination to secondary internal organs and peripheral external sites, and supervening gram-negative bacterial infection. Here we describe the role of a novel myxoma virus protein encoded by the M-T5 open reading frame during pathogenesis. The myxoma virus M-T5 protein possesses no significant sequence homology to nonviral proteins but is a member of a larger poxviral superfamily designated host range proteins. An M-T5- mutant virus was constructed by disruption of both copies of the M-T5 gene followed by insertion of the selectable marker p7.5Ecogpt. Although the M-T5- deletion mutant replicated with wild-type kinetics in rabbit fibroblasts, infection of a rabbit CD4+ T-cell line (RL5) with the myxoma virus M-T5- mutant virus resulted in the rapid and complete cessation of both host and viral protein synthesis, accompanied by the manifestation of all the classical features of programmed cell death. Infection of primary rabbit peripheral mononuclear cells with the myxoma virus M-T5-mutant virus resulted in the apoptotic death of nonadherent lymphocytes but not adherent monocytes. Within the European rabbit, disruption of the M-T5 open reading frame caused a dramatic attenuation of the rapidly lethal myxomatosis infection, and none of the infected rabbits displayed any of the characteristic features of myxomatosis. The two most significant histological observations in rabbits infected with the M-T5-mutant virus were (i) the lack of progression of the infection past the primary site of inoculation, coupled with the establishment of a rapid and effective inflammatory reaction, and (ii) the inability of the virus to initiate a cellular reaction within secondary immune organs. We conclude that M-T5 functions as a critical virulence factor by allowing productive infection of

  18. Yellow Nail Syndrome With Dramatic Improvement of Nail Manifestations After Endoscopic Sinus Surgery

    Directory of Open Access Journals (Sweden)

    Yu Hosokawa

    2017-07-01

    Full Text Available Objectives: Yellow nail syndrome (YNS is a rare disease of unknown cause characterized by the triad of yellow nails, respiratory manifestations, and lymphedema. Although several therapies for YNS have been reported, there is no common consensus in the treatment. In this case report, we present a case of 56-year-old woman with YNS, whose nail manifestation was dramatically improved after endoscopic sinus surgery for the treatment of chronic rhinosinusitis. Methods: Endoscopic sinus surgery involving middle meatal antrostomy was performed for the case of YNS with chronic rhinosinusitis and bronchiectasis resistant to antibacterial drugs. Results: A month after the surgery, the patient’s nails eventually showed dramatic improvement. Conclusions: Otorhinolaryngologists should recognize that chronic rhinosinusitis can be a symptom of YNS, and that the aggressive treatment including surgical approach for chronic rhinosinusitis may be a useful in the control of nail manifestation in YNS.

  19. Isotopic evidence for dramatic climatic changes in East Africa during the Pleistocene.

    Science.gov (United States)

    Cerling, T E; Hay, R L; O'Neil, J R

    1977-05-12

    Rainfall decreased dramatically in the Lake Turkana region 1.8-2.0 Myr ago and in the Olduvai Gorge region 0.5-0.6 Myr ago. This is documented by a major increase in the delta18O values of pedogenic and groundwater carbonates at these times. The data suggest that meteoric water of the earlier, more humid climate was 2-4 per mil lower in 18O content than modern waters of these regions.

  20. Jamie Beck’s “Cinemagraphs” in the context of dramatic theory of literature

    OpenAIRE

    Ewelina Woźniak

    2012-01-01

    The purpose of this article is to present works of a New York photographer Jamie Beck, who developed a new type of moving photography – cinemagraphs, and look at her work from the perspective of the dramatic theory of literature. Jamie Beck in her works redefines many notions related to the visual realm. Movement and time relationship, the model identity and the impact of material on the image perception are the most interesting problems, that are connected with cinemagraphs. All these issues...

  1. Discrimination, developmental science, and the law: addressing dramatic shifts in civil rights jurisprudence.

    Science.gov (United States)

    Levesque, Roger J R

    2014-01-01

    The civil rights movement fostered dramatic shifts in legal responses to discrimination based on race, gender, and a host of other group characteristics. The legal system now evinces yet another dramatic shift, as it moves from considering difference to focusing on neutrality, from efforts that seek to counter subjugation to those that adopt a "color-blind" approach. The shifting approach already has reached laws regulating responses to the group that spurred massive civil rights reform: minority youth. The shift requires a different body of empirical evidence to address it and a new look at equality jurisprudence. This article notes the need to turn to the current understanding of prejudice and discrimination for guidance, and uses, as illustration, developmental science to shed light on the development, manifestation, and alleviation of invidious discrimination. Using that understanding, the analysis details how the legal system can benefit from that research and better address discrimination in light of dramatic changes in law. The article articulates the need to address discrimination by recognizing and enlisting the law's inculcative powers through multiple sites of inculcation, ranging from families, schools, health and justice systems to religious and community groups. The discussion concludes with brief suggestions for reform benefiting from understandings of prejudice and its expression. (c) 2014 APA, all rights reserved.

  2. Dramatic Response of a Case ofRecurrent Basal Cell Carcinoma toSystemic Chemotherapy

    Directory of Open Access Journals (Sweden)

    Mohammad Mohammadianpanah

    2010-10-01

    Full Text Available Basal cell carcinoma (BCC is the most common cancer among humans, and the standard treatment is surgery. Other modalities are reserved as a second line of treatment. Topical chemotherapy may be used in primary BCC. Systemic chemotherapy has no role in the primary treatment of BCC, although it may be efficacious in metastatic cases. We report the case of a patient with persistent recurrent BCC following multiple surgeries and radiotherapy, who achieved a dramatic response with a cisplatinand 5-flourouracil chemotherapy regimen.

  3. A pragmatic-Stylistic Approach to the Study of Dramatic Texts

    Directory of Open Access Journals (Sweden)

    Khamail Ali Waheeb

    2017-08-01

    Full Text Available The present paper aims at investigating the role of interaction between stylistics and pragmatics, as two linguistic approaches, that play on the interpretation of literary texts. Stylistics is thought to be a multidisciplinary field that interacts with other linguistic fields and branches for the analysis of literary and non-literary texts. The language of dramatic texts is seen to be similar to that of everyday usage, therefore, pragmatic theories are used to interpret it. Stylistics applies these theories for stylistic effects. Consequently, the paper intends to examine the role which these two fields play in the analysis of literature and its importance

  4. Critical success factors simplified implementing the powerful drivers of dramatic business improvement

    CERN Document Server

    Howell, Marvin T

    2010-01-01

    Critical-to-success factors (CSFs) have become essential elements to strategic planning and no business can achieve consistent success without effectively adopting them. To take full advantage of CSFs, however, an organization must first understand what they are and how they can be used to drive organizational initiatives and processes. Critical Success Factors Simplified: Implementing the Powerful Drivers of Dramatic Business Improvement provides a concise manual on CSFs that will teach you how to identify and select the right CSFs, measure their impact, and adjust them as needed to reach your goals.

  5. Feature Selection in Hierarchical Feature Spaces

    OpenAIRE

    Ristoski, Petar; Paulheim, Heiko

    2014-01-01

    Feature selection is an important preprocessing step in data mining, which has an impact on both the runtime and the result quality of the subsequent processing steps. While there are many cases where hierarchic relations between features exist, most existing feature selection approaches are not capable of exploiting those relations. In this paper, we introduce a method for feature selection in hierarchical feature spaces. The method first eliminates redundant features along paths in the hier...

  6. The dramatic increase in the rate of methylisothiazolinone contact allergy in Belgium: a multicentre study.

    Science.gov (United States)

    Aerts, Olivier; Baeck, Marie; Constandt, Lieve; Dezfoulian, Bita; Jacobs, Marie-Claude; Kerre, Stefan; Lapeere, Hilde; Pierret, Lauranne; Wouters, Kristien; Goossens, An

    2014-07-01

    The rate of contact allergy and allergic contact dermatitis caused by methylisothiazolinone (MI) is dramatically increasing throughout Europe. To report on methylchloroisothiazolinone (MCI)/MI and MI allergy in Belgium. Between January 2010 and December 2012, the medical charts of 6599 patients of the Belgian Contact and Environmental Dermatitis Group were retrospectively reviewed for MCI/MI and MI sensitization by use of a standardized questionnaire. Available data on sensitization in 2081 patients tested in 2013 were also included. In 2012, the sensitization rate for MCI/MI had increased to 4.5% and that for MI to 6.0%; the latter showed a further increase to 7.2% in 2013. The people mainly affected were women with a median age of 49 years with hand and/or facial dermatitis, most often resulting from the use of cosmetics. Simultaneous reactions to octylisothiazolinone were observed. A dramatic increase in the rate of contact allergy caused by MI in cosmetics is occurring in Belgium. Notwithstanding the recent recommendation to discontinue the use of MI in leave-on cosmetics, safer use concentrations should also be determined for rinse-off products. Close monitoring of MI sensitization in the near future will be necessary, and the highest test concentrations reported for MI and MCI/MI should be included in the baseline series. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  7. Dramatic Modification of Coupled-Plasmon Resonances Following Exposure to Electron Beams.

    Science.gov (United States)

    Leng, Haixu; Szychowski, Brian; Daniel, Marie-Christine; Pelton, Matthew

    2017-08-03

    Studies of the plasmon resonances in individual and coupled metal nanoparticles often involve imaging of the nanostructures of interest in an electron microscope. We show that this process can dramatically modify the optical spectra of coupled plasmonic nanoparticles, illustrated here with the case of gold nanorod-nanosphere dimers. The spectral changes are due to the thin, partially conductive carbonaceous layer that deposits onto the particles during imaging. These changes are particularly significant for coupled nanoparticles with subnanometer interparticle gaps but have largely been neglected in previous studies of such structures, including studies intended to probe quantum-mechanical effects in plasmon coupling. Accounting for the effects of the carbonaceous layer will lead to a more accurate understanding of such systems.

  8. Dramatic Clinical Response of Relapsed Metastatic Extramammary Paget’s Disease to Trastuzumab Monotherapy

    Directory of Open Access Journals (Sweden)

    S. Wakabayashi

    2012-01-01

    Full Text Available We report the first case of 68-year-old Japanese woman with metastatic HER2-positive extramammary Paget’s disease that showed the validity of trastuzumab monotherapy. We administered trastuzumab at a loading dose of 8 mg/kg i.v., followed by a 6 mg/kg maintenance dose every three weeks according to a protocol for HER2-positive metastatic breast cancers and a near-complete response was achieved after the tenth infusion. The patient experienced a moderate headache and flushing during the first infusion, but had no advanced effects during subsequent infusions with ibuprofen and d-chlorpheniramine maleate. Given the dramatic response, the patient has had 17 infusions of trastuzumab with no disease progression. Thus, trastuzumab has few side effects and is well tolerated for elderly patients. It may become a new choice of the adjubant therapy of this disease.

  9. The philosophical poetics of George Steiner. A rhetoric and dramatic reading of Antigones

    Directory of Open Access Journals (Sweden)

    Armando Pego Puigbó

    2013-07-01

    Full Text Available In the work of George Steiner Antigones plays a singular role. It is his book more philological in a classical sense, offering simultaneously a view over the 19th and 20th century philosophical reception of the Sophocles’ tragedy. This paper tries to analyze its general design and the disposition of its parts reflecting the philosophical interpretations which Steiner himself comments according to a rhetorical grammatical methodology. Having been built on a dramatic and musical pattern, its fields of analysis are those of translation, ontology and structural anthropology from Hegel and Hölderlin to Heideggeror Lévi-Strauss. The echoes and the parallelisms between its sections reflect, on the one hand, the dialectical irony of Sören Kierkegaard and, on the other hand, the attention to the details as studied byJacob Burckhardt or Aby Warburg

  10. Acute Otitis Media-Induced Gradenigo Syndrome, a Dramatic Response to Intravenous Antibiotic

    Directory of Open Access Journals (Sweden)

    Tayebeh Kazemi

    2017-05-01

    Full Text Available Introduction: Petrositis is a rare but severe complication of acute otitis media and mastoiditis. Despite efficient antibiotic therapy, there are still reports of both intratemporal and intracranial complications of otitis media with the potential risk of high morbidity and mortality. Petrositis has traditionally been treated with surgery, but recent advances in imaging, with improved antibiotic treatment, allow more conservative management.   Case Report: In this case report we describe the clinical course and treatment of a 33-year-old man with petrous apicitis who presented with severe otalgia, retro-orbital pain, and sixth cranial nerve palsy Gradenigo syndrome. Our patient showed a dramatic response to intravenous antibiotics only, without need for any surgical intervention, even myringotomy.   Conclusion: It seems that early detection and management of this syndrome before development of other intratemporal or intracranial complications may prevent the need for surgical intervention.

  11. Jamie Beck’s “Cinemagraphs” in the context of dramatic theory of literature

    Directory of Open Access Journals (Sweden)

    Ewelina Woźniak

    2012-01-01

    Full Text Available The purpose of this article is to present works of a New York photographer Jamie Beck, who developed a new type of moving photography – cinemagraphs, and look at her work from the perspective of the dramatic theory of literature. Jamie Beck in her works redefines many notions related to the visual realm. Movement and time relationship, the model identity and the impact of material on the image perception are the most interesting problems, that are connected with cinemagraphs. All these issues are analyzed in relation to fields dealing with image: André Rouille’s and Roland Barthes’ photographic theories, art history represented by Georges Didi- Huberman and Rudolf Arnheim’s “the psychology of creative eye”.

  12. Remanences of Hellenistic Culture in a Dramatic Text by Arturo Clavijo Tisseur

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    Ronald Antonio Ramírez-Castellanos

    2016-02-01

    Full Text Available The study of remanences Greco-Roman cultural tradition in works of Santiago de Cuba literature from the colonial era to the present Republican era is a topic of attention from the most contemporary literary research in the region. From this epistemological approach, revisit texts and authors who are part of the patrimonial heritage in Santiago de Cuba, at present, little known or forgotten, can elucidate how the ideo-aesthetic components of the classical tradition has survived in the collective cultural imagination through times. Such is the case of the work of Arturo Clavijo Tisseur, poet, journalist, novelist and playwright, whose imprint has not been studied in detail. This paper therefore offers an analysis of the remanences of Hellenistic culture on the play El Arte entre sudarios (The art between shrouds, the first of the dramatic texts of this author, published in Santiago de Cuba in 1922. 

  13. Multiple sclerosis-A disease on a dramatically rising trend in Iran: Review of possible reasons

    Science.gov (United States)

    Sahraian, Mohammad Ali; Sahebkar, Mohammad; Dehghani, Rouhullah; Derakhshan-Jazari, Milad; Kazami-Moghaddam, Vahid; Kouchaki, Ebrahim

    2017-01-01

    There has been a global rising trend in recent years in the incidence of multiple sclerosis (MS). Despite being an MS low-risk region, this disease has also been recently on the rise in the Middle East. As part of the Middle East, Iran has not been spared either; however, the cause of this dramatic increase remains to be discovered. This study reviews possible reasons for this increase in Iran. Although many factors such as the increased rate of smoking, lifestyle changes, modernization, and contact with toxic solvents can be proposed as reasons for this sudden rise in the prevalence of MS in Iran, these factors cannot be taken as definite causes and further studies are required to prove their impact. PMID:28717432

  14. Dramatic inundation changes of China's two largest freshwater lakes linked to the Three Gorges Dam.

    Science.gov (United States)

    Feng, Lian; Hu, Chuanmin; Chen, Xiaoling; Zhao, Xi

    2013-09-03

    Ever since its planning in the 1990s, the Three Gorges Dam (TGD) caused endless debate in China on its potential impacts on the environment and humans. However, to date, synoptic assessment of environmental changes and their potential linkage with the TGD is still lacking. Here, we combine remote sensing, meteorological, and hydrological observations to investigate the potential influence of the TGD on the downstream freshwater lakes. A 10 year Moderate Resolution Imaging Spectroradiometer (MODIS) time series from 2000 to 2009 revealed significantly decreasing trends (3.3 and 3.6%/year) in the inundation areas of the two largest freshwater lakes of China (Poyang Lake and Dongting Lake) downstream of the TGD since its impoundment in 2003, after which both relative humidity and surface runoff coefficient of the lakes' drainages also dropped dramatically. These environmental changes appear to be linked to the TGD.

  15. THE DRAMATIC ADAPTATIO NS OF PICU PĂTRUȚ AND THE EUROPEAN MODEL

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    Ioan CRISTESCU

    2015-11-01

    Full Text Available An adequate approach to the works of Picu Pătruț – poems, adaptations, copies, popular theatre plays, miniatures – demands a discussion of the concepts of model and original creation, and an analysis of that which various scholars have deemed to be an adaptation of certain themes to fit local specifics. Popular theatre, and more so religious popular theatre, developed in Romanian territories and across all of Europe based on certain models that, as much as one may try, cannot be made secular, since they are in fact dramatizations of biblical situations. A servant of the church, though he may add his own contributions to a text or a picture, cannot and may not overstep the boundaries of the canon.

  16. Polypeptone induces dramatic cell lysis in ura4 deletion mutants of fission yeast.

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    Yuzy Matsuo

    Full Text Available Polypeptone is widely excluded from Schizosaccharomyces pombe growth medium. However, the reasons why polypeptone should be avoided have not been documented. Polypeptone dramatically induced cell lysis in the ura4 deletion mutant when cells approached the stationary growth phase, and this phenotype was suppressed by supplementation of uracil. To determine the specificity of this cell lysis phenotype, we created deletion mutants of other genes involved in de novo biosynthesis of uridine monophosphate (ura1, ura2, ura3, and ura5. Cell lysis was not observed in these gene deletion mutants. In addition, concomitant disruption of ura1, ura2, ura3, or ura5 in the ura4 deletion mutant suppressed cell lysis, indicating that cell lysis induced by polypeptone is specific to the ura4 deletion mutant. Furthermore, cell lysis was also suppressed when the gene involved in coenzyme Q biosynthesis was deleted. This is likely because Ura3 requires coenzyme Q for its activity. The ura4 deletion mutant was sensitive to zymolyase, which mainly degrades (1,3-beta-D glucan, when grown in the presence of polypeptone, and cell lysis was suppressed by the osmotic stabiliser, sorbitol. Finally, the induction of cell lysis in the ura4 deletion mutant was due to the accumulation of orotidine-5-monophosphate. Cell wall integrity was dramatically impaired in the ura4 deletion mutant when grown in the presence of polypeptone. Because ura4 is widely used as a selection marker in S. pombe, caution needs to be taken when evaluating phenotypes of ura4 mutants.

  17. Feature Multi-Selection among Subjective Features

    OpenAIRE

    Sabato, Sivan; Kalai, Adam

    2013-01-01

    When dealing with subjective, noisy, or otherwise nebulous features, the "wisdom of crowds" suggests that one may benefit from multiple judgments of the same feature on the same object. We give theoretically-motivated `feature multi-selection' algorithms that choose, among a large set of candidate features, not only which features to judge but how many times to judge each one. We demonstrate the effectiveness of this approach for linear regression on a crowdsourced learning task of predicting...

  18. Habitat features influence catch rates of near-shore bull shark (Carcharhinus leucas) in the Queensland Shark Control Program, Australia 1996-2012

    Science.gov (United States)

    Haig, Jodie A.; Lambert, Gwladys I.; Sumpton, Wayne D.; Mayer, David G.; Werry, Jonathan M.

    2018-01-01

    Understanding shark habitat use is vital for informing better ecological management of coastal areas and shark populations. The Queensland Shark Control Program (QSCP) operates over ∼1800 km of Queensland coastline. Between 1996 and 2012, catch, total length and sex were recorded from most of the 1992 bull shark (Carcharhinus leucas) caught on drum lines and gill-nets as part of the QSCP (sex and length was not successfully recorded for all individuals). Gear was set at multiple sites within ten locations. Analysis of monthly catch data resulted in a zero-inflated dataset for the 17 years of records. Five models were trialled for suitability of standardising the bull shark catch per unit effort (CPUE) using available habitat and environmental data. Three separate models for presence-absence and presence-only were run and outputs combined using a delta-lognormal framework for generalized linear and generalized additive models. The delta-lognormal generalized linear model approach resulted in best fit to explain patterns in CPUE. Greater CPUE occurred on drum lines, and greater numbers of bull sharks were caught on both gear types in summer months, with tropical sites, and sites with greater adjacent wetland habitats catching consistently more bull sharks compared to sub-tropical sites. The CPUE data did not support a hypothesis of population decline indicative of coastal overfishing. However, the total length of sharks declined slightly through time for those caught in the tropics; subtropical catches were dominated by females and a large proportion of all bull sharks caught were smaller than the size-at-maturity reported for this species. These factors suggest that growth and sex overfishing of Queensland bull shark populations may be occurring but are not yet detectable in the available data. The data highlight available coastal wetlands, river size, length of coastline and distance to the 50 m depth contour are important for consideration in future whole of

  19. Online feature selection with streaming features.

    Science.gov (United States)

    Wu, Xindong; Yu, Kui; Ding, Wei; Wang, Hao; Zhu, Xingquan

    2013-05-01

    We propose a new online feature selection framework for applications with streaming features where the knowledge of the full feature space is unknown in advance. We define streaming features as features that flow in one by one over time whereas the number of training examples remains fixed. This is in contrast with traditional online learning methods that only deal with sequentially added observations, with little attention being paid to streaming features. The critical challenges for Online Streaming Feature Selection (OSFS) include 1) the continuous growth of feature volumes over time, 2) a large feature space, possibly of unknown or infinite size, and 3) the unavailability of the entire feature set before learning starts. In the paper, we present a novel Online Streaming Feature Selection method to select strongly relevant and nonredundant features on the fly. An efficient Fast-OSFS algorithm is proposed to improve feature selection performance. The proposed algorithms are evaluated extensively on high-dimensional datasets and also with a real-world case study on impact crater detection. Experimental results demonstrate that the algorithms achieve better compactness and higher prediction accuracy than existing streaming feature selection algorithms.

  20. Dramatic Effects of Speech Task on Motor and Linguistic Planning in Severely Dysfluent Parkinsonian Speech

    Science.gov (United States)

    Van Lancker Sidtis, Diana; Cameron, Krista; Sidtis, John J.

    2012-01-01

    In motor speech disorders, dysarthric features impacting intelligibility, articulation, fluency and voice emerge more saliently in conversation than in repetition, reading or singing. A role of the basal ganglia in these task discrepancies has been identified. Further, more recent studies of naturalistic speech in basal ganglia dysfunction have…

  1. The Mixmasters: A Smart Marketing Mix Helps a Small College Dramatically Increase Student Enrollments.

    Science.gov (United States)

    Paul, R. Dana; Stark, Ken

    1983-01-01

    Adrian College's steady increase and confidence in enrollment projections stem from a research-based, thoughtfully planned, carefully implemented, highly controlled marketing programs. Four major elements of a successful marketing mix are identified: product, price, place, promotion. (MLW)

  2. Dramatic regression and bleeding of a duodenal GIST during preoperative imatinib therapy: case report and review

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    Schwandner Thilo

    2010-06-01

    Full Text Available Abstract Background Gastrointestinal stromal tumors (GISTs are the most common mesenchymal tumors of the digestive tract. The majority of GISTs is located in the stomach. Only 3-5% of GISTs are located in the duodenum associated with an increased risk of gastrointestinal bleeding as primary manifestation. With response rates of up to 90%, but complications like bleeding due to tumor necrosis in 3%, imatinib mesylate dramatically altered the pre- and postoperative therapy for GIST patients. Case presentation A 58-year-old female patient presented with acute upper gastrointestinal bleeding 2 weeks after a giant GIST of the duodenum had been diagnosed. Neoadjuvant imatinib therapy had been initiated to achieve a tumor downsizing prior to surgery. During emergency laparotomy a partial duodenopancreatectomy was performed to achieve a complete resection of the mass. Histology revealed a high-malignancy GIST infiltrating the duodenal wall. Adjuvant imatinib therapy was initiated. At follow-up (19 months the patient is still alive and healthy. Conclusion Giant GISTs of the duodenum are rare and - in contrast to other localizations - harbour a higher risk of serious bleeding as primary manifestation. Tumor necrosis and tumor bleeding are rare but typical adverse effects of imatinib therapy especially during treatment of high-malignancy GIST. In GIST patients with increased risk of tumor bleeding neoadjuvant imatinib therapy should thoroughly be performed during hospitalization. In cases of duodenal GIST primary surgery should be considered as treatment alternative.

  3. Dramatic colour changes in a bird of paradise caused by uniquely structured breast feather barbules.

    Science.gov (United States)

    Stavenga, Doekele G; Leertouwer, Hein L; Marshall, N Justin; Osorio, Daniel

    2011-07-22

    The breast-plate plumage of male Lawes' parotia (Parotia lawesii) produces dramatic colour changes when this bird of paradise displays on its forest-floor lek. We show that this effect is achieved not solely by the iridescence--that is an angular-dependent spectral shift of the reflected light--which is inherent in structural coloration, but is based on a unique anatomical modification of the breast-feather barbule. The barbules have a segmental structure, and in common with many other iridescent feathers, they contain stacked melanin rodlets surrounded by a keratin film. The unique property of the parotia barbules is their boomerang-like cross section. This allows each barbule to work as three coloured mirrors: a yellow-orange reflector in the plane of the feather, and two symmetrically positioned bluish reflectors at respective angles of about 30°. Movement during the parotia's courtship displays thereby achieves much larger and more abrupt colour changes than is possible with ordinary iridescent plumage. To our knowledge, this is the first example of multiple thin film or multi-layer reflectors incorporated in a single structure (engineered or biological). It nicely illustrates how subtle modification of the basic feather structure can achieve novel visual effects. The fact that the parotia's breast feathers seem to be specifically adapted to give much stronger colour changes than normal structural coloration implies that colour change is important in their courtship display.

  4. A Dramatic Increase in Tongue Tie-Related Articles: A 67 Years Systematic Review.

    Science.gov (United States)

    Bin-Nun, Alona; Kasirer, Yair M; Mimouni, Francis B

    2017-09-01

    Tongue tie or ankyloglossia articles are recorded in the Medline since 1949. To study trends in yearly number of tongue tie or ankyloglossia publications. Medline search engine was used to determine the yearly number of published consensus statements from 1949 to 2016. Keywords of tongue tie OR ankyloglossia OR frenotomy OR frenulotomy were used for the search. Articles were classified as case reports (or series), reviews, editorials (or opinions), cohort studies, clinical trials (nonrandomized), randomized controlled trials (RCT), and systematic reviews (SR). Linear or polynomial regression was used to determine trends. We also systematically summarized all RCTs published to date. The total number of yearly published articles increased in a cubic fashion (r(2) = 82.6%, p articles belonged to low hierarchy categories (case reports 37.9%, reviews 15.4%, and editorials/opinions 13.4%), with only 8 RCTs and 10 SRs (all of them published during the last 10 years of the study period). The yearly number of tongue tie or ankyloglossia-related articles has increased dramatically in past few years. Most articles bring little evidence, but the past few years have witnessed publication of few RCTs and SRs. If this trend continues, much more solid evidence should accumulate about diagnosis and management of tongue tie, as it relates to breastfeeding and other outcomes.

  5. Who gets custody now? Dramatic changes in children's living arrangements after divorce.

    Science.gov (United States)

    Cancian, Maria; Meyer, Daniel R; Brown, Patricia R; Cook, Steven T

    2014-08-01

    This article reexamines the living arrangements of children following their parents' divorce, using Wisconsin Court Records, updating an analysis that showed relatively small but significant increases in shared custody in the late 1980s and early 1990s. These changes have accelerated markedly in the intervening years: between 1988 and 2008, the proportion of mothers granted sole physical custody fell substantially, the proportion of parents sharing custody increased dramatically, and father-sole custody remained relatively stable. We explore changes in the correlates of alternative custody outcomes, showing that some results from the earlier analysis still hold (for example, cases with higher total family income are more likely to have shared custody), but other differences have lessened (shared-custody cases have become less distinctive as they have become more common). Despite the considerable changes in marriage and divorce patterns over this period, we do not find strong evidence that the changes in custody are related to changes in the characteristics of families experiencing a divorce; rather, changes in custody may be the result of changes in social norms and the process by which custody is determined.

  6. Patterns and potential drivers of dramatic changes in Tibetan lakes, 1972-2010.

    Directory of Open Access Journals (Sweden)

    Yingkui Li

    Full Text Available Most glaciers in the Himalayas and the Tibetan Plateau are retreating, and glacier melt has been emphasized as the dominant driver for recent lake expansions on the Tibetan Plateau. By investigating detailed changes in lake extents and levels across the Tibetan Plateau from Landsat/ICESat data, we found a pattern of dramatic lake changes from 1970 to 2010 (especially after 2000 with a southwest-northeast transition from shrinking, to stable, to rapidly expanding. This pattern is in distinct contrast to the spatial characteristics of glacier retreat, suggesting limited influence of glacier melt on lake dynamics. The plateau-wide pattern of lake change is related to precipitation variation and consistent with the pattern of permafrost degradation induced by rising temperature. More than 79% of lakes we observed on the central-northern plateau (with continuous permafrost are rapidly expanding, even without glacial contributions, while lakes fed by retreating glaciers in southern regions (with isolated permafrost are relatively stable or shrinking. Our study shows the limited role of glacier melt and highlights the potentially important contribution of permafrost degradation in predicting future water availability in this region, where understanding these processes is of critical importance to drinking water, agriculture, and hydropower supply of densely populated areas in South and East Asia.

  7. Regulatory Bodies: Dramatic Creativity, Control and the Commodity of Lady Audley's Secret

    Directory of Open Access Journals (Sweden)

    Kate Mattacks

    2009-04-01

    Full Text Available 'Lady Audley's Secret' resonates with a sense of theatricality grounded in the eponymous heroine's propensity for visual tactics to attract an audience. Repositioning the dramatic exchange between actress and audience within the domestic sphere sensitised the reader to the question of diagnosing morally degenerative artificiality whilst involving the reader in the complicit act of encouraging Lady Audley's performance through consumer demand. This complex relationship between consumerism, theatre and society saw Lady Audley's figure assume an iconic status, but little has been written on the creative interplay between the novel and the theatre itself. Beginning with the way in which aspiring actresses used Lady Audley as a model to display their histrionic variety, I argue that the theatre used her character to engage with the complex connections between drama and commodity culture. Her autophagy in favour of a false identity provided a model for actresses to visualise self-commodification whilst highlighting the tension between the material practices of the theatre and the materiality of commodity culture. The drive for regulation of the theatrical medium finds its locus in the licensing text/published acting edition of William E. Suter's 'Lady Audley's Secret' (1863. Here I move to show how Suter's adaptation functioned as a site where the state regulation of the theatre was explored and contested. These unauthorised images of Lady Audley's containment came to symbolise not only the regulatory processes of licensing and copyright, but also the creative exploitation of a commodity culture critiqued through the dehumanised form of Braddon's original heroine.

  8. Patterns and Potential Drivers of Dramatic Changes in Tibetan Lakes, 1972–2010

    Science.gov (United States)

    Li, Yingkui; Liao, Jingjuan; Guo, Huadong; Liu, Zewen; Shen, Guozhuang

    2014-01-01

    Most glaciers in the Himalayas and the Tibetan Plateau are retreating, and glacier melt has been emphasized as the dominant driver for recent lake expansions on the Tibetan Plateau. By investigating detailed changes in lake extents and levels across the Tibetan Plateau from Landsat/ICESat data, we found a pattern of dramatic lake changes from 1970 to 2010 (especially after 2000) with a southwest-northeast transition from shrinking, to stable, to rapidly expanding. This pattern is in distinct contrast to the spatial characteristics of glacier retreat, suggesting limited influence of glacier melt on lake dynamics. The plateau-wide pattern of lake change is related to precipitation variation and consistent with the pattern of permafrost degradation induced by rising temperature. More than 79% of lakes we observed on the central-northern plateau (with continuous permafrost) are rapidly expanding, even without glacial contributions, while lakes fed by retreating glaciers in southern regions (with isolated permafrost) are relatively stable or shrinking. Our study shows the limited role of glacier melt and highlights the potentially important contribution of permafrost degradation in predicting future water availability in this region, where understanding these processes is of critical importance to drinking water, agriculture, and hydropower supply of densely populated areas in South and East Asia. PMID:25372787

  9. Systemic Lupus Erythematosus and Bullous Pemphigoid with Dramatic Response to Dapsone.

    Science.gov (United States)

    Maggio, Maria Cristina; Corsello, Giovanni; Prinzi, Eugenia; Cimaz, Rolando

    2017-03-29

    BACKGROUND Bullous pemphigoid is an autoimmune blistering disease, with relapses, isolated or associated with other autoimmune diseases such as systemic lupus erythematosus (SLE). Joint manifestations rapidly respond to small or moderate doses of corticosteroids, whereas skin manifestations usually respond to antimalarial drugs. CASE REPORT We describe the clinical case of an 11-year-old girl with SLE. She showed bullous skin lesions with arthralgia, mild proteinuria, resolved after steroid treatment. At the tapering of her prednisone dose, the patient had new skin lesions requiring an increased dose of prednisone. She started dapsone at the dosage of 1 mg/kg/day, maintaining low dose prednisone; this treatment was successfully followed by the dramatic disappearance of skin lesions and limb pain. CONCLUSIONS Bullous skin lesions can represent the first clinical presentation of pediatric SLE and could influence the treatment and the outcome of these patients. This case showed an atypical course as both skin manifestations and arthritis promptly and persistently resolved with dapsone without the use of high-dose glucocorticoids. Only a few cases of patients with SLE associated with bullous pemphigoid have been reported in the literature, and very few in the pediatric population.

  10. Dramatic Increases of Soil Microbial Functional Gene Diversity at the Treeline Ecotone of Changbai Mountain.

    Science.gov (United States)

    Shen, Congcong; Shi, Yu; Ni, Yingying; Deng, Ye; Van Nostrand, Joy D; He, Zhili; Zhou, Jizhong; Chu, Haiyan

    2016-01-01

    The elevational and latitudinal diversity patterns of microbial taxa have attracted great attention in the past decade. Recently, the distribution of functional attributes has been in the spotlight. Here, we report a study profiling soil microbial communities along an elevation gradient (500-2200 m) on Changbai Mountain. Using a comprehensive functional gene microarray (GeoChip 5.0), we found that microbial functional gene richness exhibited a dramatic increase at the treeline ecotone, but the bacterial taxonomic and phylogenetic diversity based on 16S rRNA gene sequencing did not exhibit such a similar trend. However, the β-diversity (compositional dissimilarity among sites) pattern for both bacterial taxa and functional genes was similar, showing significant elevational distance-decay patterns which presented increased dissimilarity with elevation. The bacterial taxonomic diversity/structure was strongly influenced by soil pH, while the functional gene diversity/structure was significantly correlated with soil dissolved organic carbon (DOC). This finding highlights that soil DOC may be a good predictor in determining the elevational distribution of microbial functional genes. The finding of significant shifts in functional gene diversity at the treeline ecotone could also provide valuable information for predicting the responses of microbial functions to climate change.

  11. Membrane Proteins Are Dramatically Less Conserved than Water-Soluble Proteins across the Tree of Life.

    Science.gov (United States)

    Sojo, Victor; Dessimoz, Christophe; Pomiankowski, Andrew; Lane, Nick

    2016-11-01

    Membrane proteins are crucial in transport, signaling, bioenergetics, catalysis, and as drug targets. Here, we show that membrane proteins have dramatically fewer detectable orthologs than water-soluble proteins, less than half in most species analyzed. This sparse distribution could reflect rapid divergence or gene loss. We find that both mechanisms operate. First, membrane proteins evolve faster than water-soluble proteins, particularly in their exterior-facing portions. Second, we demonstrate that predicted ancestral membrane proteins are preferentially lost compared with water-soluble proteins in closely related species of archaea and bacteria. These patterns are consistent across the whole tree of life, and in each of the three domains of archaea, bacteria, and eukaryotes. Our findings point to a fundamental evolutionary principle: membrane proteins evolve faster due to stronger adaptive selection in changing environments, whereas cytosolic proteins are under more stringent purifying selection in the homeostatic interior of the cell. This effect should be strongest in prokaryotes, weaker in unicellular eukaryotes (with intracellular membranes), and weakest in multicellular eukaryotes (with extracellular homeostasis). We demonstrate that this is indeed the case. Similarly, we show that extracellular water-soluble proteins exhibit an even stronger pattern of low homology than membrane proteins. These striking differences in conservation of membrane proteins versus water-soluble proteins have important implications for evolution and medicine. © The Author 2016. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

  12. Europium(III) DOTA-derivatives having ketone donor pendant arms display dramatically slower water exchange

    Science.gov (United States)

    Green, Kayla N.; Viswanathan, Subha; Rojas-Quijano, Federico A.; Kovacs, Zoltan; Sherry, A. Dean

    2011-01-01

    A series of new 1,4,7,10-tetraazacyclododecane-derivatives having a combination of amide and ketone donor groups as side-arms were prepared and their complexes with europium(III) studied in detail by high resolution NMR spectroscopy. The chemical shift of the Eu3+-bound water resonance, the chemical exchange saturation transfer (CEST) characteristics of the complexes, and the bound water residence lifetimes (τm) were found to vary dramatically with the chemical structure of the side-arms. Substitution of ketone oxygen donor atoms for amide oxygen donor atoms resulted in an increase in residence water lifetimes (τm) and a decrease in chemical shift of the Eu3+-bound water molecule (Δω). These experimental results along with density functional theory (DFT) calculations demonstrate that introduction of weakly donating oxygen atoms in these complexes results in a much weaker ligand field, more positive charge on the Eu3+ ion and an increased water residence lifetime as expected for a dissociative mechanism. These results provide new insights into the design of paramagnetic CEST agents with even slower water exchange kinetics that will make them more efficient for in vivo imaging applications. PMID:21306137

  13. Combination of clopidogrel and everolimus dramatically reduced the development of transplant arteriosclerosis in murine aortic allografts.

    Science.gov (United States)

    Eckl, Sebastian; Heim, Christian; Abele-Ohl, Silke; Hoffmann, Julia; Ramsperger-Gleixner, Martina; Weyand, Michael; Ensminger, Stephan M

    2010-09-01

    Our group has shown that platelet inhibition with clopidogrel, an antagonist of the P2Y12 adenosine diphosphate receptor on platelets, reduced the formation of transplant arteriosclerosis. The aim of this study was to investigate whether a combination of cyclosporin or everolimus with clopidogrel has a beneficial effect on the development of transplant arteriosclerosis. Fully MHC mismatched C57Bl/6 (H2(b)) donor aortas were transplanted into CBA.J (H2(k)) recipients and mice received either clopidogrel alone (1 mg/kg/day) or in combination with cyclosporin (2 mg/kg/day) or everolimus (0.05 mg/kg/day). Grafts were analysed by histology and morphometry on day 30 after transplantation. In mice treated with clopidogrel alone, transplant arteriosclerosis was significantly reduced [intima proliferation 56 +/- 11% vs. 81 +/- 7% (control)/n = 7]. Daily application of everolimus reduced the development of transplant arteriosclerosis compared with untreated controls [intima proliferation of 29 +/- 9% vs. 81 +/- 7% (control)/n = 7]. Strikingly, combination of clopidogrel and everolimus almost abolished the formation of transplant arteriosclerosis [intima proliferation: 11 +/- 8% vs. 81 +/- 7% (control)/n = 7]. By contrast, combination of cyclosporin and clopidogrel compared with clopidogrel alone showed no additive effect. These results demonstrate that combination of platelet- and mammalian target of Rapamycin-inhibition can dramatically reduce the development of transplant arteriosclerosis.

  14. Clinical simulation with dramatization: gains perceived by students and health professionals.

    Science.gov (United States)

    Negri, Elaine Cristina; Mazzo, Alessandra; Martins, José Carlos Amado; Pereira, Gerson Alves; Almeida, Rodrigo Guimarães Dos Santos; Pedersoli, César Eduardo

    2017-08-03

    to identify in the literature the gains health students and professionals perceive when using clinical simulation with dramatization resources. integrative literature review, using the method proposed by the Joanna Briggs Institute (JBI). A search was undertaken in the following databases: Latin American and Caribbean Health Sciences Literature, Web of Science, National Library of Medicine, Cumulative Index to Nursing and Allied Health Literature, The Cochrane Library, Scopus, Scientific Electronic Library Online. 53 studies were analyzed, which complied with the established inclusion criteria. Among the different gains obtained, satisfaction, self-confidence, knowledge, empathy, realism, reduced level of anxiety, comfort, communication, motivation, capacity for reflection and critical thinking and teamwork stand out. the evidence demonstrates the great possibilities to use dramatization in the context of clinical simulation, with gains in the different health areas, as well as interprofessional gains. identificar na literatura quais os ganhos percebidos pelos estudantes e profissionais da área de saúde, utilizando-se da simulação clínica realizada com recursos da dramatização. revisão integrativa da literatura, com a metodologia proposta pelo Instituto Joanna Briggs (JBI), com busca nas bases de dados: Literatura Latino-Americana e do Caribe em Ciências da Saúde, Web of Science, National Library of Medicine, Cumulative Index to Nursing and Allied Health Literature, The Cochrane Library, Scopus, Scientific Electronic Library Online. foram analisados 53 estudos, que atenderam os critérios de inclusão estabelecidos. Entre os diversos ganhos obtidos, destaca-se a satisfação, autoconfiança, conhecimento, empatia, realismo, diminuição do nível de ansiedade, conforto, comunicação, motivação, capacidade de reflexão e de pensamento crítico e trabalho em equipe. as evidências demonstram a ampla possibilidade de uso da dramatização no contexto de

  15. Urbanization dramatically altered the water balances of a paddy field dominated basin in Southern China

    Science.gov (United States)

    Hao, L.; Sun, G.; Liu, Y.; Wan, J.; Qin, M.; Qian, H.; Liu, C.; John, R.; Fan, P.; Chen, J.

    2015-02-01

    Rice paddy fields provide important ecosystem services (e.g., food production, water retention, carbon sequestration) to a large population globally. However, these benefits are declining as a result of rapid environmental and socioeconomic transformations characterized by population growth, urbanization, and climate change in many Asian countries. This case study examined the responses of streamflow and watershed water balances to the decline of rice paddy fields due to urbanization in the Qinhuai River Basin in southern China where massive industrialization has occurred in the region during the past three decades. We found that streamflow increased by 58% and evapotranspiration (ET) decreased by 23% during 1986-2013 as a result of an increase in urban areas of three folds and reduction of rice paddy field by 27%. Both highflows and lowflows increased significantly by about 28% from 2002 to 2013. The increases in streamflow were consistent with the decreases in ET and leaf area index monitored by independent remote sensing MODIS data. The reduction in ET and increase in streamflow was attributed to the large cropland conversion that overwhelmed the effects of regional climate warming and climate variability. Converting traditional rice paddy fields to urban use dramatically altered land surface conditions from a water-dominated to a human-dominated landscape, and thus was considered as one of the extreme types of contemporary hydrologic disturbances. The ongoing large-scale urbanization in the rice paddy-dominated regions in the humid southern China, and East Asia, will likely elevate stormflow volume, aggravate flood risks, and intensify urban heat island effects. Understanding the linkage between land use change and changes in hydrological processes is essential for better management of urbanizing watersheds.

  16. Cellulolytic protist numbers rise and fall dramatically in termite queens and kings during colony foundation.

    Science.gov (United States)

    Shimada, Keisuke; Lo, Nathan; Kitade, Osamu; Wakui, Akane; Maekawa, Kiyoto

    2013-04-01

    Among the best-known examples of mutualistic symbioses is that between lower termites and the cellulolytic flagellate protists in their hindguts. Although the symbiosis in worker termites has attracted much attention, there have been only a few studies of protists in other castes. We have performed the first examination of protist population dynamics in queens and kings during termite colony foundation. Protist numbers, as well as measurements of hindgut and reproductive tissue sizes, were undertaken at five time points over 400 days in incipient colonies of Reticulitermes speratus, as well as in other castes of mature colonies of this species. We found that protist numbers increased dramatically in both queens and kings during the first 50 days of colony foundation but began to decrease by day 100, eventually disappearing by day 400. Hindgut width followed a pattern similar to that of protist numbers, while ovary and testis widths increased significantly only at day 400. Kings were found to contain higher numbers of protists than queens in incipient colonies, which may be linked to higher levels of nutrient transfer from kings to queens than vice versa, as is known in some other termite species. Protists were found to be abundant in soldiers from mature colonies but absent in neotenics. This probably reflects feeding of soldiers by workers via proctodeal trophallaxis and of reproductives via stomodeal trophallaxis. The results reveal the dynamic nature of protist numbers during colony foundation and highlight the trade-offs that exist between reproduction and parental care during this critical phase of the termite life cycle.

  17. Chemical modification of lysine residues in lysozyme may dramatically influence its amyloid fibrillation.

    Science.gov (United States)

    Morshedi, Dina; Ebrahim-Habibi, Azadeh; Moosavi-Movahedi, Ali Akbar; Nemat-Gorgani, Mohsen

    2010-04-01

    Studies on the aggregation of mutant proteins have provided new insights into the genetics of amyloid diseases and the role of the net charge of the protein on the rate, extent, and type of aggregate formation. In the present work, hen egg white lysozyme (HEWL) was employed as the model protein. Acetylation and (separately) citraconylation were employed to neutralize the charge on lysine residues. Acetylation of the lysine residues promoted amyloid formation, resulting in more pronounced fibrils and a dramatic decline in the nucleation time. In contrast, citraconylation produced the opposite effect. In both cases, native secondary and tertiary structures appeared to be retained. Studies on the effect of pH on aggregation suggested greater possibilities for amorphous aggregate formation rather than fibrillation at pH values closer to neutrality, in which the protein is known to take up a conformation more similar to its native form. This is in accord with reports in the literature suggesting that formation of amorphous aggregates is more favored under relatively more native conditions. pH 5 provided a critical environment in which a mixture of amorphous and fibrillar structures were observed. Use of Tango and Aggrescan software which describe aggregation tendencies of different parts of a protein structure suggested critical importance of some of the lysine residues in the aggregation process. Results are discussed in terms of the importance of the net charge in control of protein-protein interactions leading to aggregate formation and possible specific roles of lysine residues 96 and 97. Copyright 2009 Elsevier B.V. All rights reserved.

  18. Permeability enhancers dramatically increase zanamivir absolute bioavailability in rats: implications for an orally bioavailable influenza treatment.

    Directory of Open Access Journals (Sweden)

    Eric H Holmes

    Full Text Available We have demonstrated that simple formulations composed of the parent drug in combination with generally regarded as safe (GRAS permeability enhancers are capable of dramatically increasing the absolute bioavailability of zanamivir. This has the advantage of not requiring modification of the drug structure to promote absorption, thus reducing the regulatory challenges involved in conversion of an inhaled to oral route of administration of an approved drug. Absolute bioavailability increases of up to 24-fold were observed when Capmul MCM L8 (composed of mono- and diglycerides of caprylic/capric acids in glycerol was mixed with 1.5 mg of zanamivir and administered intraduodenally to rats. Rapid uptake (t(max of 5 min and a C(max of over 7200 ng/mL was achieved. Variation of the drug load or amount of enhancer demonstrated a generally linear variation in absorption, indicating an ability to optimize a formulation for a desired outcome such as a targeted C(max for enzyme saturation. No absorption enhancement was observed when the enhancer was given 2 hr prior to drug administration, indicating, in combination with the observed tmax, that absorption enhancement is temporary. This property is significant and aligns well with therapeutic applications to limit undesirable drug-drug interactions, potentially due to the presence of other poorly absorbed polar drugs. These results suggest that optimal human oral dosage forms of zanamivir should be enteric-coated gelcaps or softgels for intraduodenal release. There continues to be a strong need and market for multiple neuraminidase inhibitors for influenza treatment. Creation of orally available formulations of inhibitor drugs that are currently administered intravenously or by inhalation would provide a significant improvement in treatment of influenza. The very simple GRAS formulation components and anticipated dosage forms would require low manufacturing costs and yield enhanced convenience. These results

  19. Administration-route dependency of absorption of glycyrrhizin in rats: intraperitoneal administration dramatically enhanced bioavailability.

    Science.gov (United States)

    Yamamura, Y; Santa, T; Kotaki, H; Uchino, K; Sawada, Y; Iga, T

    1995-02-01

    The pharmacokinetic behavior of glycyrrhizin after intravenous (i.v.), oral and intraperitoneal (i.p.) administration was compared in rats. The elimination half-life, total body clearance and volume of distribution at steady-state of glycyrrhizin were not significantly different among doses (2, 10 and 50 mg/kg i.v.). Glycyrrhizin was only detected in the plasma (maximum level: 1.3 micrograms/ml) after oral administration of 50 mg/kg. From comparison of the area under the plasma concentration-time curves after i.v. and oral administration of 50 mg/kg, the bioavailability of glycyrrhizin was estimated to be approximately 1%. Glycyrrhizin was stable for at least 3 h in gastric juice. The plasma concentration of glycyrrhizin after oral administration to neomycin-treated rats was not significantly different from that after administration to untreated rats. Furthermore, in in situ absorption study the cumulative ratio of glycyrrhizin in the mesenteric venous plasma after injection was only 1-2% of the dose. From these results, it appeared that the extremely low bioavailability by the oral route may be due to poor absorption of glycyrrhizin from the intestinal tract. On the other hand, the plasma concentration of glycyrrhizin rapidly increased after i.p. administration of doses of 2, 10 and 50 mg/kg, and reached a maximum level (4.7, 33.0 and 238.9 micrograms/ml, respectively) within 30 min. The bioavailability (65-90%) of glycyrrhizin after i.p. administration was enhanced dramatically. The i.p. route of administration may thus improve the bioavailability of glycyrrhizin.

  20. A Woman's Place: A Journey Through Misogyny - An Exploration of Violence Against Women and the Efficacy of Dramatic Movement/Physical Theatre as a Pedagogical Tool of Transformative Learning.

    OpenAIRE

    Djiapouras, Emilia; Herriot, Christopher

    2017-01-01

    Emilia Djiapouras is an undergraduate student (Level 5 at the time of writing) of Youth Work & Community Development. This paper is an example of co-creation of knowledge by students and academics at DMU. This paper conveys the effectiveness of expressive methodologies (dramatic movement/physical theatre) as a conduit for social learning. The audience/readers are encouraged to analyse the projected learning outcomes of a featured performance, achieving gender solidarity and an acute awaren...

  1. They're Lovin' It: How Preschool Children Mediated Their Funds of Knowledge into Dramatic Play

    Science.gov (United States)

    Karabon, Anne

    2017-01-01

    The funds of knowledge framework promotes connecting community contexts with curriculum aimed to activate children's prior knowledge. Typically, teachers determine what knowledge sources harmonise best with their existing programming, potentially omitting particular resources that may not align. Young children, on the other hand, can act as agents…

  2. The Future of Gulf Security in a Region of Dramatic Change: Mutual Equities and Enduring Relationships

    Science.gov (United States)

    2011-06-20

    program? The moderator set the stage by explaining that recent U.S. polices in the Middle East for dealing with Arab uprisings have exacerbated Arab...widespread disenchantment with and anxi - ety about the reliability of the United States as a security partner—feelings exacerbated by the United States

  3. Urbanization dramatically altered the water balances of a paddy field-dominated basin in southern China

    Science.gov (United States)

    Hao, L.; Sun, G.; Liu, Y.; Wan, J.; Qin, M.; Qian, H.; Liu, C.; Zheng, J.; John, R.; Fan, P.; Chen, J.

    2015-07-01

    Rice paddy fields provide important ecosystem services (e.g., food production, water retention, carbon sequestration) to a large population globally. However, these benefits are diminishing as a result of rapid environmental and socioeconomic transformations, characterized by population growth, urbanization, and climate change in many Asian countries. This case study examined the responses of stream flow and watershed water balances to the decline of rice paddy fields due to urbanization in the Qinhuai River basin in southern China, where massive industrialization has occurred during the past 3 decades. We found that stream flow increased by 58 % and evapotranspiration (ET) decreased by 23 % during 1986-2013 as a result of a three-fold increase in urban areas and a reduction of rice paddy fields by 27 %. Both high flows and low flows increased significantly by about 28 % from 2002 to 2013. The increases in stream flow were consistent with the decreases in ET and leaf area index monitored by independent remote sensing MODIS (Moderate Resolution Imaging Spectroradiometer) data. Attribution analysis, based on two empirical models, indicated that land-use/land-cover change contributed about 82-108 % of the observed increase in stream flow from 353 ± 287 mm yr-1 during 1986-2002 to 556 ± 145 during 2003-2013. We concluded that the reduction in ET was largely attributed to the conversion of cropland to urban use. The effects of land-use change overwhelmed the effects of regional climate warming and climate variability. Converting traditional rice paddy fields to urban use dramatically altered land surface conditions from an artificial wetland-dominated landscape to an urban land-use- dominated one, and thus was considered an extreme type of contemporary hydrologic disturbance. The ongoing large-scale urbanization of the rice paddy-dominated regions, in humid southern China and East Asia, will likely elevate storm-flow volume, aggravate flood risks, and intensify urban

  4. Dramatic Enhancement of Genome Editing by CRISPR/Cas9 Through Improved Guide RNA Design

    OpenAIRE

    Farboud, Behnom; Meyer, Barbara J.

    2015-01-01

    © 2015 by the Genetics Society of America. Success with genome editing by the RNA-programmed nuclease Cas9 has been limited by the inability to predict effective guide RNAs and DNA target sites. Not all guide RNAs have been successful, and even those that were, varied widely in their efficacy. Here we describe and validate a strategy for Caenorhabditis elegans that reliably achieved a high frequency of genome editing for all targets tested in vivo. The key innovation was to design guide RNAs ...

  5. Unsupervised Feature Subset Selection

    DEFF Research Database (Denmark)

    Søndberg-Madsen, Nicolaj; Thomsen, C.; Pena, Jose

    2003-01-01

    This paper studies filter and hybrid filter-wrapper feature subset selection for unsupervised learning (data clustering). We constrain the search for the best feature subset by scoring the dependence of every feature on the rest of the features, conjecturing that these scores discriminate some ir...... irrelevant features. We report experimental results on artificial and real data for unsupervised learning of naive Bayes models. Both the filter and hybrid approaches perform satisfactorily....

  6. Hessian fly (Mayetiola destructor) attack causes a dramatic shift in carbon and nitrogen metabolism in wheat.

    Science.gov (United States)

    Zhu, Lieceng; Liu, Xuming; Liu, Xiang; Jeannotte, Richard; Reese, John C; Harris, Marion; Stuart, Jeffrey J; Chen, Ming-Shun

    2008-01-01

    Carbon and nitrogen (C/N) metabolism and allocation within the plant have important implications for plant-parasite interactions. Many plant parasites manipulate the host by inducing C/N changes that benefit their own survival and growth. Plant resistance can prevent this parasite manipulation. We used the wheat-Hessian fly (Mayetiola destructor) system to analyze C/N changes in plants during compatible and incompatible interactions. The Hessian fly is an insect but shares many features with plant pathogens, being sessile during feeding stages and having avirulence (Avr) genes that match plant resistance genes in gene-for-gene relationships. Many wheat genes involved in C/N metabolism were differentially regulated in plants during compatible and incompatible interactions. In plants during compatible interactions, the content of free carbon-containing compounds decreased 36%, whereas the content of free nitrogen-containing compounds increased 46%. This C/N shift was likely achieved through a coordinated regulation of genes in a number of central metabolic pathways, including glycolysis, the tricarboxylic acid cycle, and amino-acid synthesis. Our data on plants during compatible interactions support recent findings that Hessian fly larvae create nutritive cells at feeding (attack) sites and manipulate host plants to enhance their own survival and growth. In plants during incompatible interactions, most of the metabolic genes examined were not affected or down-regulated.

  7. [A-type lamins and progeroïd syndromes : persistent farnesylation with dramatic effects].

    Science.gov (United States)

    Navarro, Claire L; Poitelon, Yannick; Lévy, Nicolas

    2008-10-01

    Hutchinson-Gilford Progeria (HGPS), a rare and severe developmental disorder characterized by features recalling premature aging, and Restrictive Dermopathy (RD), a neonatal lethal genodermatosis, have recently been identified as being primary or secondary . These heterogeneous disorders are caused by altered Lamin maturation pathway. In physiological conditions, mature Lamin A is obtained through a series of post-translational processing steps performed on a protein precursor, Prelamin A. The major pathophysiological mechanism involved in Progeria is an aberrant splicing due to a de novo heterozygous point mutation, leading to the accumulation of truncated Lamin A precursor. The same aberrant splicing mechanism was involved in RD, whereas the majority of RD cases are caused by ZMPSTE24/FACE1 inactivation, a key enzyme involved in the Lamin A maturation pathway. In functional terms, all these conditions share the same pathophysiological mechanism, i.e. the intranuclear accumulation of Lamin A precursors, which cannot be fully processed and exert a toxic effect on nuclear homeostasis. In this article, we review the structure and functions of A-type Lamins, focusing namely on HGPS, RD or MAD disorders, in relation to existing animal models and possible future therapeutic approaches.

  8. Learning Form and Function by Dance-Dramatizing Cultural Legends to Drum Rhythms Wearing Student-Made Animal Masks

    Science.gov (United States)

    Gray, Phyllis; Rule, Audrey C.; Kirkland Holmes, Gloria; Logan, Stephanie R.; Alert, Andrea L.; Mason, Cynthia A.

    This study examined the self-efficacy in science, art, dance, and music; attitudes concerning contributions of people of various ethnic/cultural groups; and science learning of students involved in an after-school arts-integrated science enrichment project. Students dramatized three traditional animal legends from African, Native American, and…

  9. Learning Form and Function by Dance-Dramatizing Cultural Legends to Drum Rhythms Wearing Student-Made Animal Masks

    Science.gov (United States)

    Gray, Phyllis; Rule, Audrey C.; Kirkland Holmes, Gloria; Logan, Stephanie R.; Alert, Andrea L.; Mason, Cynthia A.

    2016-01-01

    This study examined the self-efficacy in science, art, dance, and music; attitudes concerning contributions of people of various ethnic/cultural groups; and science learning of students involved in an after-school arts-integrated science enrichment project. Students dramatized three traditional animal legends from African, Native American, and…

  10. TAR (Theatre as Representation) as a Provocative Teaching Tool in School Administration: A Dramatized Inclusive Classroom Scenario

    Science.gov (United States)

    Meyer, Matthew J.; Young, David C.

    2013-01-01

    The following dramatized classroom scenario depicts a teacher struggling with the nature of an inclusive learning environment, with instructional leadership and supervision of instruction as the theoretical and practical backdrop. The purpose of this article is to demonstrate how the use of a TAR (theatre as representation) case study can be used…

  11. 30 years of data reveal dramatic increase in abundance of brown trout following the removal of a small hydrodam

    DEFF Research Database (Denmark)

    Birnie-Gauvin, Kim; Larsen, Martin Hage; Nielsen, Jan

    2017-01-01

    and spawning of fish. In the present study, we present thirty years of data from electrofishing surveys obtained at two sites, both prior to and following the removal of a small-scale hydropower dam in Central Jutland, Denmark. We demonstrate that the dam removal has led to a dramatic increase in trout density...

  12. Home in the heat: Dramatic seasonal variation in home range of desert golden eagles informs management for renewable energy development

    Science.gov (United States)

    Melissa Braham; Tricia Miller; Adam E. Duerr; Michael Lanzone; Amy Fesnock; Larry LaPre; Daniel Driscoll; Todd. Katzner

    2015-01-01

    Renewable energy is expanding quickly with sometimes dramatic impacts to species and ecosystems. To understand the degree to which sensitive species may be impacted by renewable energy projects, it is informative to know how much space individuals use and how that space may overlap with planned development. We used global positioning system-global system for mobile...

  13. The Big Glamorous Monster (or Lady Gaga's Adventures at Sea): Improving Student Writing through Dramatic Approaches in Schools

    Science.gov (United States)

    Lee, Bridget Kiger; Enciso, Patricia

    2017-01-01

    Drawing on assets-oriented, sociocultural theories of imagination and learning, the authors argue that the improvisational qualities and expanded resources of dramatic approaches to teaching make a positive difference in the quality of and persistence in students' story writing. The authors describe findings from a controlled quasi-experimental…

  14. Featureous: A Tool for Feature-Centric Analysis of Java Software

    DEFF Research Database (Denmark)

    Olszak, Andrzej; Jørgensen, Bo Nørregaard

    2010-01-01

    Feature-centric comprehension of source code is necessary for incorporating user-requested modifications during software evolution and maintenance. However, such comprehension is difficult to achieve in case of large object-oriented programs due to the size, complexity, and implicit character...... of mappings between features and source code. To support programmers in overcoming these difficulties, we present a feature-centric analysis tool, Featureous. Our tool extends the NetBeans IDE with mechanisms for efficient location of feature implementations in legacy source code, and an extensive analysis...... of the discovered feature-code relations through a number of analytical views....

  15. Dramatic enhancement of genome editing by CRISPR/Cas9 through improved guide RNA design.

    Science.gov (United States)

    Farboud, Behnom; Meyer, Barbara J

    2015-04-01

    Success with genome editing by the RNA-programmed nuclease Cas9 has been limited by the inability to predict effective guide RNAs and DNA target sites. Not all guide RNAs have been successful, and even those that were, varied widely in their efficacy. Here we describe and validate a strategy for Caenorhabditis elegans that reliably achieved a high frequency of genome editing for all targets tested in vivo. The key innovation was to design guide RNAs with a GG motif at the 3' end of their target-specific sequences. All guides designed using this simple principle induced a high frequency of targeted mutagenesis via nonhomologous end joining (NHEJ) and a high frequency of precise DNA integration from exogenous DNA templates via homology-directed repair (HDR). Related guide RNAs having the GG motif shifted by only three nucleotides showed severely reduced or no genome editing. We also combined the 3' GG guide improvement with a co-CRISPR/co-conversion approach. For this co-conversion scheme, animals were only screened for genome editing at designated targets if they exhibited a dominant phenotype caused by Cas9-dependent editing of an unrelated target. Combining the two strategies further enhanced the ease of mutant recovery, thereby providing a powerful means to obtain desired genetic changes in an otherwise unaltered genome. Copyright © 2015 by the Genetics Society of America.

  16. Collaborative Writing Features

    Science.gov (United States)

    Yong Mei Fung

    2010-01-01

    As part of a research study on collaborative writing, this paper discusses defining and facilitating features that occur during face-to-face collaboration, based on the literature and research. The defining features are mutual interaction, negotiations, conflict, and shared expertise. Facilitating features include affective factors, use of L1,…

  17. Featureous: infrastructure for feature-centric analysis of object-oriented software

    DEFF Research Database (Denmark)

    Olszak, Andrzej; Jørgensen, Bo Nørregaard

    2010-01-01

    understanding and modification are essential during software evolution and maintenance. In this paper, we present an infrastructure built on top of the NetBeans IDE called Featureous that allows for rapid construction of tools for feature-centric analysis of object-oriented software. Our infrastructure......The decentralized nature of collaborations between objects in object-oriented software makes it difficult to understand how user-observable program features are implemented and how their implementations relate to each other. It is worthwhile to improve this situation, since feature-centric program...... encompasses a lightweight feature location mechanism, a number of analytical views and an API allowing for addition of third-party extensions. To form a common conceptual framework for future feature-centric extensions, we propose to structure feature centric analysis along three dimensions: perspective...

  18. Utility Green Pricing Programs: A Statistical Analysis of Program Effectiveness

    Energy Technology Data Exchange (ETDEWEB)

    Wiser, R.; Olson, S.; Bird, L.; Swezey, B.

    2004-02-01

    This report analyzes actual utility green pricing program data to provide further insight into which program features might help maximize both customer participation in green pricing programs and the amount of renewable energy purchased by customers in those programs.

  19. Weighted Feature Distance

    DEFF Research Database (Denmark)

    Ortiz-Arroyo, Daniel; Yazdani, Hossein

    2017-01-01

    The accuracy of machine learning methods for clustering depends on the optimal selection of similarity functions. Conventional distance functions for the vector space might cause an algorithm to being affected by some dominant features that may skew its final results. This paper introduces a flexible...... environment for mining algorithms that uses the most suitable similarity functions to cover the diversity of both vector and feature spaces. The paper describes some well known conventional distance functions and introduces Weighted Feature Distance (WFD) and Prioritized Weighted Feature Distance (PWFD......). These novel functions attempt to balance the impact of the dominant features by covering both feature and vector spaces, additionally to optionally allowing us to increase or decrease the impact of some features. We evaluate and compare the accuracy of our proposed WFD(s) on conventional fuzzy...

  20. Dramatic Rewritings of the Spanish Golden Age Theater of Cervantes´s La fuerza de la sangre

    Directory of Open Access Journals (Sweden)

    Juan Manuel Escudero Baztán

    2013-12-01

    Full Text Available This paper analyzes the Golden age spanish theater recreations of Cervantes’s exemplary novel La fuerza de la sangre. Specifically, the paper reviews three important stages in these recreations: La fuerza de la sangre of Guillen de Castro, El agravio satisfecho de Castillo Solórzano, and No hay cosa como callar de Calderon de la Barca. Different rewrites indicate a close relationship between the three dramatic texts through intertextuality and other influences.

  1. Ice absorption features in the 5-8 mu m range

    NARCIS (Netherlands)

    Keane, JV; Tielens, AGGM; Boogert, ACA; Whittet, DCB; Cox, P; Kessler, MF

    1999-01-01

    ISO-SWS spectra (2 - 45 mu m) have been obtained towards a large number of luminous young stellar objects. Here, we present a study of absorption features towards the two objects NGC: 7538:IRS9 and Mon R2:IRS3, for the spectral region 5 - 8 mu m. The shape of these features changes dramatically from

  2. Dramatic Stained Glass.

    Science.gov (United States)

    Prater, Michael

    2002-01-01

    Describes an art project that is appropriate for students in fifth through twelfth grade in which they create Gothic-style stained-glass windows. Discusses how college students majoring in elementary education created stained-glass windows. Addresses how to adapt this lesson for younger students. (CMK)

  3. Inexpensive Dramatic Pneumatic Lift

    Science.gov (United States)

    Morse, Robert A.

    2017-01-01

    Various experiments and demonstrations relate air pressure and air pressure difference to force and area. Carpenter and Minnix describe a large-scale pneumatic lift in which a person sitting on a board atop a plastic garbage bag is lifted when the bag is connected to the exhaustport of a vacuum cleaner, which easily lifts the person. This article…

  4. [The expression of programmed death receptor 1 in non-small cell lung cancer and its clinicopathological features and prognosis showed a connection with epidermal growth factor receptor gene mutations].

    Science.gov (United States)

    Yin, H; Liao, C G; Wang, Y Q; Li, Z; Fan, L L; Qian, M L; Lu, N

    2017-06-23

    Objective: To investigate the relationships between the expression of programmed death 1 (PD-1) and the epidermal growth factor receptor (EGFR) gene mutations in non-small cell lung cancer (NSCLC). The study also attempted to investigate the clinicopathological features and prognosis in NSCLC patients. Methods: The expression of PD-1 protein in 88 cases of NSCLC tumor tissues and adjacent tissues was detected by immunohistochemistry. The mutations of EGFR in NSCLC were detected by Polymerase Chain Reaction-Amplification Refractory Mutation System(PCR-ARMS) method. The expression of PD-1 and patients' clinical characteristics and prognosis were analyzed. Results: PD-1 was positive in 63.6%(56/88) NSCLC tumor tissues, which was significantly higher than that in adjacent normal tissues (21.6%, 19/88) (Pgene mutations were found in 43 cases (48.9%), in which 30 cases (69.8%)were PD-1 positive expression. 45 cases had the wild types of EGFR gene, in which 26 cases (57.8%) were PD-1 positive. There were 24 cases of 19Del EGFR mutations, including 20 cases (83.3%) of PD-1 positive expression. 19 patients had 21L858 EGFR mutations, including 10 cases (52.6%) of PD-1 positive expression. The expression of PD-1 in NSCLC was related to patients' smoking status, lymph node metastasis and EGFR gene mutations (Pgene, the median progression-free survival time of PD-1 positive and negative expression was 25.21 and 38.24 months, respectively. The difference was statistically significant (P=0.024). The median progression-free survival time in 43 cases of EGFR mutant patients with PD-1 positive and negative expression was 21.23 and 31.44 months. The difference was not statistically significant (P=0.128). Conclusions: PD-1 expresses in both EGFR mutant and wild-type NSCLC, and its expression levelis different with various EGFR mutations. The expression of PD-1 in NSCLC is related to the prognosis of patients, and the prognosis of patients with positive PD-1 expression was poor.

  5. JCE Feature Columns

    Science.gov (United States)

    Holmes, Jon L.

    1999-05-01

    The Features area of JCE Online is now readily accessible through a single click from our home page. In the Features area each column is linked to its own home page. These column home pages also have links to them from the online Journal Table of Contents pages or from any article published as part of that feature column. Using these links you can easily find abstracts of additional articles that are related by topic. Of course, JCE Online+ subscribers are then just one click away from the entire article. Finding related articles is easy because each feature column "site" contains links to the online abstracts of all the articles that have appeared in the column. In addition, you can find the mission statement for the column and the email link to the column editor that I mentioned above. At the discretion of its editor, a feature column site may contain additional resources. As an example, the Chemical Information Instructor column edited by Arleen Somerville will have a periodically updated bibliography of resources for teaching and using chemical information. Due to the increase in the number of these resources available on the WWW, it only makes sense to publish this information online so that you can get to these resources with a simple click of the mouse. We expect that there will soon be additional information and resources at several other feature column sites. Following in the footsteps of the Chemical Information Instructor, up-to-date bibliographies and links to related online resources can be made available. We hope to extend the online component of our feature columns with moderated online discussion forums. If you have a suggestion for an online resource you would like to see included, let the feature editor or JCE Online (jceonline@chem.wisc.edu) know about it. JCE Internet Features JCE Internet also has several feature columns: Chemical Education Resource Shelf, Conceptual Questions and Challenge Problems, Equipment Buyers Guide, Hal's Picks, Mathcad

  6. The effects of everolimus on tuberous sclerosis-associated lesions can be dramatic but may be impermanent.

    Science.gov (United States)

    Miller, Joseph M; Wachsman, Ashley; Haker, Katherine; Majlessipour, Fataneh; Danielpour, Moise; Puliyanda, Dechu

    2015-01-01

    Tuberous sclerosis complex (TSC) predisposes to the development of benign lesions within multiple organ systems, including the brain, kidneys, heart, lungs, and skin. Disease mortality is due to space-occupying subependymal giant cell astrocytomas and hemorrhage-prone renal angiomyolipomas. The recent use of mTORC1 inhibitors, such as everolimus, has allowed for direct targeting of TSC-associated mass lesions without apparent effect on surrounding tissues. Because of the mechanism of these drugs, there is reason to believe that these effects are not durable and that there may be need for continued long-term maintenance therapy. We present a case of TSC-associated mass lesions that were ill-suited for definitive surgical therapy. The patient was started on everolimus, however due to a complex social situation treatment was discontinued and ultimately resumed many months later. Radiologic studies acquired before and after each period of therapeutic onset/cessation reveal the dramatic but impermanent effects of mTORC1 inhibition. While everolimus provides a non-invasive way to treat TSC-associated lesions, patients may require lifelong therapy. When termination of therapy is considered, the patient should be made aware of the expectation of potentially dramatic increases in lesion size. If consideration is to be given to definitive surgical therapy, it should be pursued while the patient is still on the medication, or at least soon after treatment is halted.

  7. Coherent branching feature bisimulation

    Directory of Open Access Journals (Sweden)

    Tessa Belder

    2015-04-01

    Full Text Available Progress in the behavioral analysis of software product lines at the family level benefits from further development of the underlying semantical theory. Here, we propose a behavioral equivalence for feature transition systems (FTS generalizing branching bisimulation for labeled transition systems (LTS. We prove that branching feature bisimulation for an FTS of a family of products coincides with branching bisimulation for the LTS projection of each the individual products. For a restricted notion of coherent branching feature bisimulation we furthermore present a minimization algorithm and show its correctness. Although the minimization problem for coherent branching feature bisimulation is shown to be intractable, application of the algorithm in the setting of a small case study results in a significant speed-up of model checking of behavioral properties.

  8. Radiologic features of esophagitis

    Energy Technology Data Exchange (ETDEWEB)

    Kressel, H.Y.; Glick, S.N.; Laufer, I.; Banner, M.

    1981-05-15

    The radiographic features of 31 cases of esophagitis confirmed by endoscopy and biopsy were studied by double-contrast techniques. The morphologic findings are analyzed and the changes noted in the infectious and peptic types of esophagitis are contrasted.

  9. LHON and extraocular features

    National Research Council Canada - National Science Library

    Yu‐Wai‐Man, P

    2015-01-01

    LHON is typically a monosymptomatic disease but additional features such as cardiac conduction defects, peripheral neuropathy, dystonia, and myopathy have been reported as occurring more frequently among LHON carriers...

  10. Daily bowel care program

    Science.gov (United States)

    ... gov/ency/patientinstructions/000133.htm Daily bowel care program To use the sharing features on this page, ... Work with your health care provider. Basic Bowel Program Keeping active helps prevent constipation. Try to walk, ...

  11. MAIN SURFACE FEATURES

    Directory of Open Access Journals (Sweden)

    MINTIANSCHI Andrei V.

    2010-07-01

    Full Text Available Surface characterization means splitting the surface geometry into basic components based usually on some functional requirement. These components can have different shapes, scales of size, distribution in space and can be constrained by multiple boundaries in height and position. The measurement can influence the importance of a parameter or feature. This paper presents the main features that need to be considered when a surface is analyzed, especially the roughness and the waviness.

  12. FEATUREOUS: AN INTEGRATED ENVIRONMENT FOR FEATURE-CENTRIC ANALYSIS AND MODIFICATION OF OBJECT-ORIENTED SOFTWARE

    DEFF Research Database (Denmark)

    Olszak, Andrzej; Jørgensen, Bo Nørregaard

    2011-01-01

    software maintenance and evolution, this situation needs to change. In this paper, we present Featureous, an integrated development environment built on top of the NetBeans IDE that facilitates feature-centric analysis of object-oriented software. Our integrated development environment encompasses......The decentralized nature of collaborations between objects in object-oriented software makes it difficult to understand the implementations of user-observable program features and their respective interdependencies. As feature-centric program understanding and modification are essential during...... a lightweight feature location mechanism, a number of reusable analytical views, and necessary APIs for supporting future extensions. The base of the integrated development environment is a conceptual framework comprising of three complementary dimensions of comprehension: perspective, abstraction...

  13. Material Programming

    DEFF Research Database (Denmark)

    Vallgårda, Anna; Boer, Laurens; Tsaknaki, Vasiliki

    2017-01-01

    , and color, but additionally being capable of sensing, actuating, and computing. Indeed, computers will not be things in and by themselves, but embedded into the materials that make up our surroundings. This also means that the way we interact with computers and the way we program them, will change....... Consequently we ask what the practice of programming and giving form to such materials would be like? How would we be able to familiarize ourselves with the dynamics of these materials and their different combinations of cause and effect? Which tools would we need and what would they look like? Will we program...... these computational composites through external computers and then transfer the code them, or will the programming happen closer to the materials? In this feature we outline a new research program that floats between imagined futures and the development of a material programming practice....

  14. Changing things around: Dramatic aspect in the Pericope Adulterae (Jn 7:53–8:11

    Directory of Open Access Journals (Sweden)

    Piet van Staden

    2015-09-01

    Full Text Available In this article the transactional model of narrative as expounded by Louise Rosenblatt, supported by an analysis in terms of dramatic aspect, is employed to show how the interpolated scene in John 7:53–8:11 (known as the Pericope Adulterae and hereafter referred to as PA functions as a pivot of power in the gospel. The content of the scene, as well as its placement within the gospel, serves to promote an aesthetic reading that focusses attention on the experience during the reading event. Awareness of sensations, images, feelings and ideas from past experiences, as well as the sounds and rhythms of the words become important. The reader responds to the aesthetic transaction, the various elements of total experience, rather than simply to the text, during and after the reading event.

  15. Chekhov’s dramatic art and cinematograph: implementation of author’s assumption in active shot mode

    Directory of Open Access Journals (Sweden)

    Bezrukov Andrei Nikolayevich

    2017-07-01

    Full Text Available The article analyses the art specificity of Chekhov’s legacy in dramatic art based on implementing in national film industry. Chekhov’s drama is divertive in its interpretation by the reader, the researcher, and in the director’s cut. Eccentricity frequently occurs in his dramaturgy. In literary text this device is not only a part of aesthetic picturing but also the form of overthinking, transformation of reality and changing the attitude to reality. The main division of the text form alters the character’s reality and his life into the moving picture frame, and changes the set visual representation into the symbol. Cinematic art allows to connect Chekhov’s text to the ornamentality of the image.

  16. Identity transformation and a changed lifestyle following dramatic weight loss and body-contouring surgery: An exploratory study.

    Science.gov (United States)

    Gilmartin, Jo; Long, Andrew; Soldin, Mark

    2015-10-01

    This article reports on two major quality-of-life perception changes for patients who had undergone plastic surgery following dramatic weight loss. The exploratory, qualitative study was undertaken with 20 patients from one teaching hospital. In-depth interviews were conducted, and a thematic analysis of the data was undertaken. The results provide unique glimpses of surgical consumption empowering and facilitating 'identity transformation', embracing improved physical function and enhanced self-esteem, confidence and quality of life, and a 'changed lifestyle'. For a minority, identity transformation was sometimes interrupted by 'identity lag', posing the need for additional health-care support throughout the adjustment process. The study provides additional insight into existing quantitative studies, adding to the body of knowledge in this area. © The Author(s) 2013.

  17. Moses revisited. August Strindberg’s and Edvard Munch’s dramatic use of the figure of Moses

    Directory of Open Access Journals (Sweden)

    Camilla Storskog

    2011-06-01

     1903 and Den fri Kjærligheds By (The City of Free Love, ca. 1905. In the first case, the focus is on the examination of Moses as an archetypical character. Analogies are subsequently drawn between the biblical hero and other dramatic characters in the production of the Swedish playwright, such as Gustav Vasa or Birger jarl. In the latter case, I outline the strategy for a parodic reuse of the biblical source in Munch’s invention of a modern Moses created to mock his fellow painter and maestro Christian Krohg and the bohemian ideal of free love. Although the qualities of the Moses character take on different and opposite meanings in the two authors, it is of interest that the issue of a return to the common heritage of biblical culture should make itself evident in the years following both Strindberg’s and Munch’s farewell to the secular milieus of the Bohème.

  18. Biostratigraphic evidence of dramatic Holocene uplift of Robinson Crusoe Island, Juan Fernández Ridge, SE Pacific Ocean

    Science.gov (United States)

    Sepúlveda, P.; Le Roux, J. P.; Lara, L. E.; Orozco, G.; Astudillo, V.

    2014-09-01

    A study of the biostratigraphy and sedimentology of Holocene deposits on Robinson Crusoe Island (RCI) on the Juan Fernández Ridge (JFR) indicates that a~dramatic but localized uplift occurred since 8000 BP, at a rate of about 8.5 mm yr-1. In fact, supratidal flats and sand layers with marine gastropods (mostly Nerita sp.) are now exposed ca. 70 m a.s.l., and covered by transitional dunes. The last volcanic activity on RCI occurred at ca. 0.8 Ma (active hotspot located 280 km further west) and there is no sign of a compensating bulge that explains this uplift, isobaths of the sea floor instead suggesting general subsidence. However, modeling indicates that large-scale landslides followed by isostatic rebound are a viable explanation, partially reflected in the low-resolution bathymetry of the area.

  19. Dramatis persona in poetical and practical approach of dramatic text in 17th century French theory of theatre

    Directory of Open Access Journals (Sweden)

    Michał Bajer

    2009-01-01

    Full Text Available The idea of the dramatis persona posited by the first French theatre theorists of the Richelieu circle, Jean Chapelain and Jules de la Mesnardiere, emerges as a quite literał implementation of the Aristotelian concepts unfolded in the sixth and fifteenth chapter of his Poetics. In a later period, the third of the aforementioned group of authors, François Hédelin d’Aubignac, dismisses the Aristotelian categories, erecting his theory upon the elements adopted from the Roman theory of rhetoric. The analysis of the Persona in classical drama theory allows to reconstruct the relation between these two 17th century dramatic approaches. The former is the traditional perspective relying on the postulations of the Aristotelian theory. The latter, which is a practical grasp, is new to the 17th century’s dramatic mindset, and was formulated by abbé d’Aubignac. Whereas the axis of poetics is the structural analysis of a work of art, it is the functioning of that work of art in the theatrical process of communication between the stage and the audience that remains the core interest of the practical approach. In this process, the rhetorical effect of presence of the dramatis persona should by created in the imagination of the spectator-auditor. The subject of analysis is common to both perspectives and the discrepancies concem merely aspects of its description. Therefore poetics and practice are neither competitive nor mutually exclusive, but can both legitimately coexist in the description of the very same work of art.

  20. Dramatic secretion of recombinant protein expressed in tobacco cells with a designer glycopeptide tag is highly impacted by medium composition.

    Science.gov (United States)

    Zhang, Ningning; Dolan, Maureen; Wu, Di; Phillips, Gregory C; Xu, Jianfeng

    2016-12-01

    Cell growth medium composition has profound impacts on the O -glycosylation of a "designer" arabinogalactan protein-based module; full glycosylation is essential in directing efficient extracellular secretion of the tagged recombinant protein. Expression of recombinant proteins in plant cells as fusion with a de novo designed hydroxyproline (Hyp)-O-glycosylated peptide (HypGP) tag, termed HypGP engineering technology, resulted in dramatically increased secreted protein yields. This is due to the function of the HypGP tag as a molecular carrier in promoting efficient transport of conjoined proteins into culture media. To optimize the cell culture to achieve the best secreted protein yields, the medium effects on the cell growth and protein secretion were investigated using as a model system the tobacco BY-2 cell expressing enhanced green fluorescence protein (EGFP) fused with a (SP)32 tag (32 tandem repeats of "Ser-Pro" motif). The (SP)32 tag was found to undergo two-stage Hyp-O-glycosylation in plant cells with the dramatic secretion of the conjoined EGFP correlating with the triggering of the second-stage glycosylation. The BY-2 cell culture in SH medium generated a high secreted protein yield (125 mg/L) with a low cell biomass accumulation (~7.5 gDW/L). In contrast, very low secreted protein yields (~1.5 mg/L) with a high cell biomass accumulation (13.5 gDW/L) were obtained in MS medium. The macronutrients, specifically, the nitrogen supply greatly impacted the glycosylation of the (SP)32 tag and subsequent protein secretion. Modified MS medium with reduced nitrogen levels boosted the secreted EGFP yields to 168 mg/L. This study demonstrates the profound impacts of medium composition on the secreted yields of a HypGP-tagged protein, and provides a basis for medium design to achieve the highest productivity of the HypGP engineering technology.

  1. Stochastic Constraint Programming

    OpenAIRE

    Walsh, Toby

    2009-01-01

    To model combinatorial decision problems involving uncertainty and probability, we introduce stochastic constraint programming. Stochastic constraint programs contain both decision variables (which we can set) and stochastic variables (which follow a probability distribution). They combine together the best features of traditional constraint satisfaction, stochastic integer programming, and stochastic satisfiability. We give a semantics for stochastic constraint programs, and propose a number...

  2. SAPHIRE 8 New Features and Capabilities

    Energy Technology Data Exchange (ETDEWEB)

    Curtis Smith

    2008-08-01

    The Systems Analysis Programs for Hands-on Integrated Reliability Evaluations (SAPHIRE) software performs probabilistic risk assessment (PRA) calculations. SAPHIRE is used in support of NRC’s risk-informed programs such as the Accident Sequence Precursor (ASP) program, Management Directive 8.3, “NRC Incident Investigation Program,” or the Significance Determination Process (SDP). It is also used to develop and run the Standardized Plant Analysis Risk (SPAR) models. SAPHIRE Version 8 is a new version of the software with an improved interface and capabilities to support risk-informed programs. SAPHIRE Version 8 is designed to easily handle larger and more complex models. Applications of previous SAPHIRE versions indicated the need to build and solve models with a large number of sequences. Risk assessments that include endstate evaluations for core damage frequency and large, early release frequency evaluations have greatly increased the number of sequences required. In addition, the complexity of the models has increased since risk assessments evaluate both potential internal and external events, as well as different plant operational states. Special features of SAPHIRE 8 help create and run integrated models which may be composed of different model types. SAPHIRE 8 includes features and capabilities that are new or improved over the current Version 7 to address the new requirements for risk-informed programs and SPAR models. These include: • Improved User Interfaces • Model development • Methods • General Support Features

  3. Are deep neural networks really learning relevant features?

    DEFF Research Database (Denmark)

    Kereliuk, Corey Mose; Larsen, Jan; Sturm, Bob L.

    In recent years deep neural networks (DNNs) have become a popular choice for audio content analysis. This may be attributed to various factors including advancements in training algorithms, computational power, and the potential for DNNs to implicitly learn a set of feature detectors. We have...... recently re-examined two works that consider DNNs for the task of music genre recognition (MGR). These papers conclude that frame-level features learned by DNNs offer an improvement over traditional, hand-crafted features such as Mel-frequency cepstrum coefficients (MFCCs). However, these conclusions were...... drawn based on training/testing using the GTZAN dataset, which is now known to contain several flaws including replicated observations and artists. We illustrate how considering these flaws dramatically changes the results, which leads one to question the degree to which the learned frame-level features...

  4. Feature displacement interpolation

    DEFF Research Database (Denmark)

    Nielsen, Mads; Andresen, Per Rønsholt

    1998-01-01

    Given a sparse set of feature matches, we want to compute an interpolated dense displacement map. The application may be stereo disparity computation, flow computation, or non-rigid medical registration. Also estimation of missing image data, may be phrased in this framework. Since the features...... often are very sparse, the interpolation model becomes crucial. We show that a maximum likelihood estimation based on the covariance properties (Kriging) show properties more expedient than methods such as Gaussian interpolation or Tikhonov regularizations, also including scale......-selection. The computational complexities are identical. We apply the maximum likelihood interpolation to growth analysis of the mandibular bone. Here, the features used are the crest-lines of the object surface....

  5. Choreographic Programming

    DEFF Research Database (Denmark)

    Montesi, Fabrizio

    , as they offer a concise view of the message flows enacted by a system. For this reason, in the last decade choreographies have been used in the development of programming languages, giving rise to a programming paradigm that in this dissertation we refer to as Choreographic Programming. Recent studies show...... endpoint described in a choreography can then be automatically generated, ensuring that such implementations are safe by construction. However, current formal models for choreographies do not deal with critical aspects of distributed programming, such as asynchrony, mobility, modularity, and multiparty...... sessions; it remains thus unclear whether choreographies can still guarantee safety when dealing with such nontrivial features. This PhD dissertation argues for the suitability of choreographic programming as a paradigm for the development of safe distributed systems. We proceed by investigating its...

  6. The Joint Philosophical Program of Russell and Wittgenstein and Its Demise

    Directory of Open Access Journals (Sweden)

    Nikolay Milkov

    2013-03-01

    Full Text Available Between April and November 1912, Bertrand Russell and Ludwig Wittgenstein were engaged in a joint philosophical program. Wittgenstein’s meeting with Gottlob Frege in December 1912 led, however, to its dissolution—the joint program was abandoned. Section 1 of this paper outlines the key points of that program, identifying what Russell and Wittgenstein each contributed to it. The second section determines precisely those features of their collaborative work that Frege criticized. Finally, building upon the evidence developed in the first two sections, section 3 recasts along previously undeveloped lines Wittgensein’s logical–philosophical discoveries in the two years following his encounter with Frege in 1912. The paper concludes, in section 4, with an overview of the dramatic consequences the Frege–Wittgenstein critique had for Russell’s philosophical development.

  7. Opioid prescriptions for pain and epidemic of overdose death: can the dramatic reduction in anesthesia mortality serve as an example?

    Directory of Open Access Journals (Sweden)

    Kissin I

    2016-06-01

    Full Text Available Igor Kissin Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA Abstract: The annual number of US deaths from prescription-opioid overdose quadrupled between 1999 and 2010 and in 2010 alone reached 16,651. Deaths from opioid overdose have now surpassed the historic death toll from another drug-related epidemic – anesthesia mortality. In 1954, Beecher and Todd published reliable data on anesthesia-related mortality in the US, estimating the annual number of deaths to be nearly 5,000. Presently anesthesia/anesthetics are reported as the underlying cause in approximately 34 deaths in the US annually. This spectacular decline in anesthesia-related mortality could serve as an example for attempts to curb the epidemic of opioid overdose death. The main reason that led to the dramatic decline in anesthesia-related mortality is the context in which anesthetics are used. It includes training of the anesthesia providers, the introduction of specific standards of patient safety, and anesthesia monitoring. I suggest that the introduction of a similar multifactorial proper context for the use of opioids in the treatment of chronic nonmalignant pain might be the same “game changer” it was for safety in anesthesia. Keywords: chronic pain, addiction, opioid-use disorder, treatment compliance, apprenticeship, metrics of opioid effectiveness, aberrant opioid-related behavior

  8. Home in the heat: Dramatic seasonal variation in home range of desert golden eagles informs management for renewable energy development

    Science.gov (United States)

    Braham, Melissa; Miller, Tricia A.; Duerr, Adam E.; Lanzone, Michael; Fesnock, Amy; LaPre, Larry; Driscoll, Daniel; Katzner, Todd E.

    2015-01-01

    Renewable energy is expanding quickly with sometimes dramatic impacts to species and ecosystems. To understand the degree to which sensitive species may be impacted by renewable energy projects, it is informative to know how much space individuals use and how that space may overlap with planned development. We used global positioning system–global system for mobile communications (GPS-GSM) telemetry to measure year-round movements of golden eagles (Aquila chrysaetos) from the Mojave Desert of California, USA. We estimated monthly space use with adaptive local convex hulls to identify the temporal and spatial scales at which eagles may encounter renewable energy projects in the Desert Renewable Energy Conservation Plan area. Mean size of home ranges was lowest and least variable from November through January and greatest in February–March and May–August. These monthly home range patterns coincided with seasonal variation in breeding ecology, habitat associations, and temperature. The expanded home ranges in hot summer months included movements to cooler, prey-dense, mountainous areas characterized by forest, grasslands, and scrublands. Breeding-season home ranges (October–May) included more lowland semi-desert and rock vegetation. Overlap of eagle home ranges and focus areas for renewable energy development was greatest when eagle home ranges were smallest, during the breeding season. Golden eagles in the Mojave Desert used more space and a wider range of habitat types than expected and renewable energy projects could affect a larger section of the regional population than was previously thought.

  9. Two centuries of the Scandinavian wolf population: patterns of genetic variability and migration during an era of dramatic decline.

    Science.gov (United States)

    Flagstad, Ø; Walker, C W; Vilà, C; Sundqvist, A-K; Fernholm, B; Hufthammer, A K; Wiig, Ø; Koyola, I; Ellegren, H

    2003-04-01

    The grey wolf (Canis lupus) was numerous on the Scandinavian peninsula in the early 19th century. However, as a result of intense persecution, the population declined dramatically and was virtually extinct from the peninsula by the 1960s. We examined historical patterns of genetic variability throughout the period of decline, from 1829 to 1979. Contemporary Finnish wolves, considered to be representative of a large eastern wolf population, were used for comparison. Mitochondrial DNA (mtDNA) variability among historical Scandinavian wolves was significantly lower than in Finland while Y chromosome variability was comparable between the two populations. This may suggest that long-distance migration from the east has been male-biased. Importantly though, as the historical population was significantly differentiated from contemporary Finnish wolves, the overall immigration rate to the Scandinavian peninsula appears to have been low. Levels of variability at autosomal microsatellite loci were high by the early 1800s but declined considerably towards the mid-20th century. At this time, approximately 40% of the allelic diversity and 30% of the heterozygosity had been lost. After 1940, however, there is evidence of several immigration events, coinciding with episodes of marked population increase in Russian Karelia and subsequent westwards migration.

  10. Opioid prescriptions for pain and epidemic of overdose death: can the dramatic reduction in anesthesia mortality serve as an example?

    Science.gov (United States)

    Kissin, Igor

    2016-01-01

    The annual number of US deaths from prescription-opioid overdose quadrupled between 1999 and 2010 and in 2010 alone reached 16,651. Deaths from opioid overdose have now surpassed the historic death toll from another drug-related epidemic - anesthesia mortality. In 1954, Beecher and Todd published reliable data on anesthesia-related mortality in the US, estimating the annual number of deaths to be nearly 5,000. Presently anesthesia/anesthetics are reported as the underlying cause in approximately 34 deaths in the US annually. This spectacular decline in anesthesia-related mortality could serve as an example for attempts to curb the epidemic of opioid overdose death. The main reason that led to the dramatic decline in anesthesia-related mortality is the context in which anesthetics are used. It includes training of the anesthesia providers, the introduction of specific standards of patient safety, and anesthesia monitoring. I suggest that the introduction of a similar multifactorial proper context for the use of opioids in the treatment of chronic nonmalignant pain might be the same "game changer" it was for safety in anesthesia.

  11. Dramatic variation of the multiferroic properties in Sr doped Ca1-xSrxMn7O12

    Directory of Open Access Journals (Sweden)

    Parul Jain

    2017-05-01

    Full Text Available CaMn7O12 is a magnetic multiferroic material, in which large ferroelectric polarization has reportedly been induced by magnetic ordering. In this work, we observe remarkable changes in the spontaneous ferroelectric polarization PS as well as the magnetization M with only 2% Sr doping. In Ca0.98Sr0.02Mn7O12, PS dramatically becomes more than double the PS in the un-doped material and concomitantly M is reduced to less than half of its value therein. Increase of PS together with the decrease of M points out clearly the coupling of PS and M in CaMn7O12. We stress here that as Ca and Sr are isovalent, no charge carriers (electrons and holes are added in the system due to Sr-doping. X-ray diffraction shows that all our Sr-doped materials Ca1-xSrxMn7O12 (x = 0.01, 0.02, 0.05, 0.10 are free from secondary phases. From our work, it becomes clear why SrMn7O12 exhibits no or weak ferroelectricity.

  12. Honokiol nanosuspensions: preparation, increased oral bioavailability and dramatically enhanced biodistribution in the cardio-cerebro-vascular system.

    Science.gov (United States)

    Han, Meihua; Yu, Xin; Guo, Yifei; Wang, Yanhong; Kuang, Haixue; Wang, Xiangtao

    2014-04-01

    Honokiol is a phytochemical component with multiple pharmacological activities, but Honokiol's wider use has been restricted by its poor solubility. Using bovine serum albumin and polyvinylpyrrolidone as stabilisers in a solvent precipitation-ultrasonication method, Honokiol nanosuspensions were prepared with a mean particle size of 116.2 nm (±2 nm), a zeta potential of -44.7 mV (±1.7 mV) and a high drug payload of 50.4 ± 0.6% (w/w). X-ray powder diffraction and differential scanning calorimetry indicated that Honokiol was in an amorphous state in the nanosuspensions, in contrast with bulk Honokiol powder. Honokiol was released faster in vitro from nanosuspensions with no burst release, and the highest 98% cumulative release was after 60 h. Honokiol nanosuspensions improved the oral bioavailability of Honokiol in in vivo studies in rats with a 3.94-fold Cmax and a 2.2-fold AUC(0-t). Remarkably, in contrast to oral administration, intraperitoneal administration of Honokiol nanosuspensions could dramatically alter the biodistribution of Honokiol, resulting in a much higher drug level and tissue bioavailability in the blood, heart and brain, benefitting the treatment of cardio-cerebro-vascular diseases. Copyright © 2014 Elsevier B.V. All rights reserved.

  13. Linkage between Three Gorges Dam impacts and the dramatic recessions in China’s largest freshwater lake, Poyang Lake

    Science.gov (United States)

    Mei, Xuefei; Dai, Zhijun; Du, Jinzhou; Chen, Jiyu

    2015-12-01

    Despite comprising a small portion of the earth’s surface, lakes are vitally important for global ecosystem cycling. However, lake systems worldwide are extremely fragile, and many are shrinking due to changing climate and anthropogenic activities. Here, we show that Poyang Lake, the largest freshwater lake in China, has experienced a dramatic and prolonged recession, which began in late September of 2003. We further demonstrate that abnormally low levels appear during October, 28 days ahead of the normal initiation of the dry season, which greatly imperiled the lake’s wetland areas and function as an ecosystem for wintering waterbirds. An increase in the river-lake water level gradient induced by the Three Gorges Dam (TGD) altered the lake balance by inducing greater discharge into the Changjiang River, which is probably responsible for the current lake shrinkage. Occasional episodes of arid climate, as well as local sand mining, will aggravate the lake recession crisis. Although impacts of TGD on the Poyang Lake recession can be overruled by episodic extreme droughts, we argue that the average contributions of precipitation variation, human activities in the Poyang Lake catchment and TGD regulation to the Poyang Lake recession can be quantified as 39.1%, 4.6% and 56.3%, respectively.

  14. Linkage between Three Gorges Dam impacts and the dramatic recessions in China's largest freshwater lake, Poyang Lake.

    Science.gov (United States)

    Mei, Xuefei; Dai, Zhijun; Du, Jinzhou; Chen, Jiyu

    2015-12-11

    Despite comprising a small portion of the earth's surface, lakes are vitally important for global ecosystem cycling. However, lake systems worldwide are extremely fragile, and many are shrinking due to changing climate and anthropogenic activities. Here, we show that Poyang Lake, the largest freshwater lake in China, has experienced a dramatic and prolonged recession, which began in late September of 2003. We further demonstrate that abnormally low levels appear during October, 28 days ahead of the normal initiation of the dry season, which greatly imperiled the lake's wetland areas and function as an ecosystem for wintering waterbirds. An increase in the river-lake water level gradient induced by the Three Gorges Dam (TGD) altered the lake balance by inducing greater discharge into the Changjiang River, which is probably responsible for the current lake shrinkage. Occasional episodes of arid climate, as well as local sand mining, will aggravate the lake recession crisis. Although impacts of TGD on the Poyang Lake recession can be overruled by episodic extreme droughts, we argue that the average contributions of precipitation variation, human activities in the Poyang Lake catchment and TGD regulation to the Poyang Lake recession can be quantified as 39.1%, 4.6% and 56.3%, respectively.

  15. Bariatric Surgery Prior to Total Joint Arthroplasty May Not Provide Dramatic Improvements In Post Arthroplasty Surgical Outcomes

    Science.gov (United States)

    Paxton, Elizabeth W.; Fisher, David; Li, Robert A.; Barber, Thomas C.; Singh, Jasvinder A.

    2014-01-01

    This study compared the total joint arthroplasty (TJA) surgical outcomes of patients who had bariatric surgery prior to TJA to TJA patients who were candidates but did not have bariatric surgery. Patients were retrospectively grouped into: Group 1 (n=69), those with bariatric surgery >2 years prior to TJA, Group 2 (n=102), those with surgery within 2 years of TJA, and Group 3 (n=11,032), those without bariatric surgery. In Group 1, 2.9% (95%CI 0.0–6.9%) had complications within 1 year compared to 5.9% (95%CI 1.3–10.4%) in Group 2, and 4.1% (95%CI 3.8–4.5%) in Group 3. 90-day readmission (7.2%, 95%CI 1.1–13.4%) and revision density (3.4/100 years of observation) was highest in Group 1. Bariatric surgery prior to TJA may not provide dramatic improvements in post-operative TJA surgical outcomes. PMID:24674730

  16. Bernard Shaw’s reconfiguration of dramatic genres as force-fields in socio-cultural and new aesthetic criticism

    OpenAIRE

    Nforbin, Gerald

    2009-01-01

    This study examines George Bernhard Shaw’s uses and transformations of dramatic genres with a view to exploring the functions of genres, regarding in particular his socio-cultural and aesthetic criticisms. The aim is to demonstrate that the transformatory use of genres can serve strong socio-critical and revolutionary aesthetic purposes. The study argues that Shaw continually experimented with dramatic forms, but his real target was their political and cultural dimensions. For Shaw, the best ...

  17. Major depression with psychotic features

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/article/000933.htm Major depression with psychotic features To use the sharing features on this page, please enable JavaScript. Major depression with psychotic features is a mental disorder in ...

  18. Imaging features of thalassemia

    Energy Technology Data Exchange (ETDEWEB)

    Tunaci, M.; Tunaci, A.; Engin, G.; Oezkorkmaz, B.; Acunas, G.; Acunas, B. [Dept. of Radiology, Istanbul Univ. (Turkey); Dincol, G. [Dept. of Internal Medicine, Istanbul Univ. (Turkey)

    1999-07-01

    Thalassemia is a kind of chronic, inherited, microcytic anemia characterized by defective hemoglobin synthesis and ineffective erythropoiesis. In all thalassemias clinical features that result from anemia, transfusional, and absorptive iron overload are similar but vary in severity. The radiographic features of {beta}-thalassemia are due in large part to marrow hyperplasia. Markedly expanded marrow space lead to various skeletal manifestations including spine, skull, facial bones, and ribs. Extramedullary hematopoiesis (ExmH), hemosiderosis, and cholelithiasis are among the non-skeletal manifestations of thalassemia. The skeletal X-ray findings show characteristics of chronic overactivity of the marrow. In this article both skeletal and non-skeletal manifestations of thalassemia are discussed with an overview of X-ray findings, including MRI and CT findings. (orig.)

  19. CBFS: high performance feature selection algorithm based on feature clearness.

    Directory of Open Access Journals (Sweden)

    Minseok Seo

    Full Text Available BACKGROUND: The goal of feature selection is to select useful features and simultaneously exclude garbage features from a given dataset for classification purposes. This is expected to bring reduction of processing time and improvement of classification accuracy. METHODOLOGY: In this study, we devised a new feature selection algorithm (CBFS based on clearness of features. Feature clearness expresses separability among classes in a feature. Highly clear features contribute towards obtaining high classification accuracy. CScore is a measure to score clearness of each feature and is based on clustered samples to centroid of classes in a feature. We also suggest combining CBFS and other algorithms to improve classification accuracy. CONCLUSIONS/SIGNIFICANCE: From the experiment we confirm that CBFS is more excellent than up-to-date feature selection algorithms including FeaLect. CBFS can be applied to microarray gene selection, text categorization, and image classification.

  20. Model Checking Feature Interactions

    DEFF Research Database (Denmark)

    Le Guilly, Thibaut; Olsen, Petur; Pedersen, Thomas

    2015-01-01

    This paper presents an offline approach to analyzing feature interactions in embedded systems. The approach consists of a systematic process to gather the necessary information about system components and their models. The model is first specified in terms of predicates, before being refined to t...... to timed automata. The consistency of the model is verified at different development stages, and the correct linkage between the predicates and their semantic model is checked. The approach is illustrated on a use case from home automation....

  1. Dramatic reduction of liver cancer incidence in young adults: 28 year follow-up of etiological interventions in an endemic area of China.

    Science.gov (United States)

    Sun, Zongtang; Chen, Taoyang; Thorgeirsson, Snorri S; Zhan, Qimin; Chen, Jianguo; Park, Ju-Hyun; Lu, Peixin; Hsia, Chu Chieh; Wang, Nengjin; Xu, Libin; Lu, Lingling; Huang, Fei; Zhu, Yuanrong; Lu, Jianhua; Ni, Zhengping; Zhang, Qinan; Wu, Yuying; Liu, Guoting; Wu, Zhiyuan; Qu, Chunfeng; Gail, Mitchell H

    2013-08-01

    Qidong City, China, has had high liver cancer incidence from endemic hepatitis B virus (HBV) infection and dietary exposure to aflatoxin. Based on etiologic studies, we began interventions in 1980 to reduce dietary aflatoxin and initiate neonatal HBV vaccination. We studied trends in liver cancer incidence rates in the 1.1 million inhabitants of Qidong and examined trends in aflatoxin exposure, staple food consumption, HBV infection markers and annual income. Aflatoxin exposure declined greatly in association with economic reform, increased earnings and educational programs to shift staple food consumption in the total population from moldy corn to fresh rice. A controlled neonatal HBV vaccination trial began in 1983 and ended in November, 1990, when vaccination was expanded to all newborns. Liver cancer incidence fell dramatically in young adults. Compared with 1980-83, the age-specific liver cancer incidence rates in 2005-08 significantly decreased 14-fold at ages 20-24, 9-fold at ages 25-29, 4-fold at ages 30-34, 1.5-fold at ages 35-39, 1.2-fold at ages 40-44 and 1.4-fold at ages 45-49, but increased at older ages. The 14-fold reduction at ages 20-24 might reflect the combined effects of reduced aflatoxin exposure and partial neonatal HBV vaccination. Decrease incidence in age groups >25 years could mainly be attributable to rapid aflatoxin reduction. Compared with 1980-83, liver cancer incidence in 1990-93 significantly decreased 3.4-fold at ages 20-24, and 1.9-fold at ages 25-29 when the first vaccinees were <11 years old.

  2. Multiplicative Multitask Feature Learning.

    Science.gov (United States)

    Wang, Xin; Bi, Jinbo; Yu, Shipeng; Sun, Jiangwen; Song, Minghu

    2016-04-01

    We investigate a general framework of multiplicative multitask feature learning which decomposes individual task's model parameters into a multiplication of two components. One of the components is used across all tasks and the other component is task-specific. Several previous methods can be proved to be special cases of our framework. We study the theoretical properties of this framework when different regularization conditions are applied to the two decomposed components. We prove that this framework is mathematically equivalent to the widely used multitask feature learning methods that are based on a joint regularization of all model parameters, but with a more general form of regularizers. Further, an analytical formula is derived for the across-task component as related to the task-specific component for all these regularizers, leading to a better understanding of the shrinkage effects of different regularizers. Study of this framework motivates new multitask learning algorithms. We propose two new learning formulations by varying the parameters in the proposed framework. An efficient blockwise coordinate descent algorithm is developed suitable for solving the entire family of formulations with rigorous convergence analysis. Simulation studies have identified the statistical properties of data that would be in favor of the new formulations. Extensive empirical studies on various classification and regression benchmark data sets have revealed the relative advantages of the two new formulations by comparing with the state of the art, which provides instructive insights into the feature learning problem with multiple tasks.

  3. Constraint-based feature validation

    OpenAIRE

    Dohmen, M.H.P.J.

    1998-01-01

    The feature modeling paradigm combines geometric and functional product information in one model. In an ideal product development environment, multiple views of a product in terms of features coexist. Feature validation concerns the validity of the feature information in all these views, focusing on validity specification and maintenance. This thesis presents a feature validation scheme based on constraints. It enables flexible and expressive feature validity maintenance. The scheme ensures t...

  4. Somatostatin dramatically stimulates growth hormone release from primate somatotrophs acting at low doses via somatostatin receptor 5 and cyclic AMP.

    Science.gov (United States)

    Córdoba-Chacón, J; Gahete, M D; Culler, M D; Castaño, J P; Kineman, R D; Luque, R M

    2012-03-01

    Somatostatin and cortistatin have been shown to act directly on pituitary somatotrophs to inhibit growth hormone (GH) release. However, previous results from nonprimate species indicate that these peptides can also directly stimulate GH secretion, at low concentrations. The relevance of this phenomenon in a nonhuman primate model was investigated in the present study by testing the impact of somatostatin/cortistatin on GH release in primary pituitary cell cultures from baboons. High doses (> 10(-10) m) of somatostatin/cortistatin did not alter basal GH secretion but blocked GH-releasing hormone (GHRH)- and ghrelin-induced GH release. However, at low concentrations (10(-17)-10(-13) m), somatostatin/cortistatin dramatically stimulated GH release to levels comparable to those evoked by GHRH or ghrelin. Use of somatostatin receptor (sst) specific agonists/antagonists, and signal transduction blockers indicated that sst2 and sst1 activation via intact adenylate cylcase and mitogen-activated protein kinase systems mediated the inhibitory actions of high-concentration somatostatin. By contrast, the stimulatory actions of low-dose somatostatin on GH release were mediated by sst5 signalling through adenylate cylcase/cAMP/protein kinase A and intracellular Ca(2+) pathways, and were additive with ghrelin (not GHRH). Notably, low-concentrations of somatostatin, similar to sst5-agonists, inhibited prolactin release. These results clearly demonstrate that the ultimate impact of somatostatin/cortistatin on hormone release is dose-dependent, cell type-selective and receptor-specific, where the stimulatory effects of low-concentration somatostatin/cortistatin on GH release extend to primates, thereby supporting the notion that this action is relevant in regulating GH secretion in humans. © 2011 The Authors. Journal of Neuroendocrinology © 2011 Blackwell Publishing Ltd.

  5. Thalidomide dramatically improves the symptoms of early-onset sarcoidosis/Blau syndrome: its possible action and mechanism.

    Science.gov (United States)

    Yasui, Kozo; Yashiro, Masato; Tsuge, Mitsuru; Manki, Akira; Takemoto, Kei; Yamamoto, Michiko; Morishima, Tsuneo

    2010-01-01

    Early-onset sarcoidosis (EOS), which occurs in children younger than 5 years of age, is associated with granulomatous lesions and a sporadic genetic mutation of the nucleotide-binding oligomerization domain 2 that causes constitutive NF-kappaB activation. The symptoms of EOS can be uncontrollable, progressive, and associated with profound complications. However, appropriate therapy is still under investigation. The aim of this study was to assess the efficacy of thalidomide in patients with severe EOS, based on etiology supporting an initial role of NF-kappaB in activation of this disease. Thalidomide was given to 2 patients with EOS (a 16-year-old girl and an 8-year-old boy) at an initial dosage of 2 mg/kg/day, and the dosage was increased if necessary. To elucidate the mechanism of the drug, peripheral blood monocytes were isolated from the patients and stimulated with cytokines (macrophage colony-stimulating factor, tumor necrosis factor alpha, and interleukin-4), and their ability to form multinucleated giant cells (MGCs) and osteoclasts was measured. Both patients showed dramatic improvement of their clinical symptoms (alleviation of fever and optic nerve papillitis, achievement of a response according to the American College of Rheumatology Pediatric 50 and Pediatric 70 criteria) and laboratory findings. Monocytes from patients with EOS had a greater ability to survive and induce MGCs and osteoclasts than those from healthy control subjects. The formation of MGCs and osteoclasts was inhibited by the presence of thalidomide. The ability of thalidomide to improve clinical symptoms and laboratory findings in patients with EOS indicates a central role for NF-kappaB activity in this disorder. Inhibition of IKK might be a pharmacologic action by which thalidomide down-regulates NF-kappaB signaling. Thalidomide may be an effective medication in patients with severe complications of EOS, including ocular involvement.

  6. Biostratigraphic evidence for dramatic Holocene uplift of Robinson Crusoe Island, Juan Fernández Ridge, SE Pacific Ocean

    Science.gov (United States)

    Sepúlveda, P.; Le Roux, J. P.; Lara, L. E.; Orozco, G.; Astudillo, V.

    2015-03-01

    Hotspot oceanic islands typically experience subsidence due to several processes related to migration of the oceanic plate away from the mantle plume and surface flexural loading. However, many other processes can interrupt subsidence, some of which may be associated with catastrophic events. A study of the biostratigraphy and sedimentology of Holocene deposits on Robinson Crusoe Island (RCI) on the Juan Fernández Ridge (JFR) indicated that dramatic uplift has occurred since 8000 years BP, at a rate of about 8.5mm yr-1. This is evidenced by supratidal flats with tepee structures and sand layers containing marine gastropods (mostly Nerita sp.) that are now exposed ca. 70 m a.s.l. The active hotspot is located 280 km further west and the last volcanic activity on RCI occurred at ca. 800 000 years BP. Long-term subsidence is evidenced by deep submerged marine abrasion terraces at RCI. As no direct evidence was found for the existence of a compensating bulge generated by the present hotspot upon which RCI would be situated, it must be concluded that subsidence in the wake of the mantle plume beneath the migrating plate was interrupted by very rapid uplift, but on a scale that did not fully compensate for the previous subsidence. This can be attributed to large-scale landslides followed by isostatic rebound, although this is only vaguely reflected in the low-resolution bathymetry of the area. To determine if this mechanism produced the uplift, a detailed bathymetric survey of the area will be required. If such a survey confirms this hypothesis, it may have implications for the short-term dynamics of vertical variations of oceanic edifices and their related effects on ecosystems and human population.

  7. Cessation of daily exercise dramatically alters precursors of hepatic steatosis in Otsuka Long-Evans Tokushima Fatty (OLETF) rats.

    Science.gov (United States)

    Rector, R Scott; Thyfault, John P; Laye, Matthew J; Morris, R Tyler; Borengasser, Sarah J; Uptergrove, Grace M; Chakravarthy, Manu V; Booth, Frank W; Ibdah, Jamal A

    2008-09-01

    The purpose of this study was to delineate potential mechanisms initiating the onset of hepatic steatosis following the cessation of daily physical activity. Four-week-old, hyperphagic/obese Otsuka Long-Evans Tokushima Fatty rats were given access to voluntary running wheels for 16 weeks to prevent the development of hepatic steatosis. The animals were then suddenly transitioned to a sedentary condition as wheels were locked (wheel lock; WL) for 5 h (WL5), 53 h (WL53) or 173 h (WL173). Importantly after the cessation of daily exercise (5-173 h), no changes occurred in body weight, fat pad mass (omental and retroperitoneal), food intake, serum insulin, hepatic triglycerides or in the exercise-suppressed hepatic stearoyl-CoA desaturase-1 and peroxisome proliferator-activated receptor-gamma protein content. However, complete hepatic fatty acid oxidation and mitochondrial enzyme activities were highest at WL5 and WL53 and dropped significantly to SED levels by WL173. In addition, cessation of daily exercise quickly increased the hepatic protein contents of fatty acid synthase and acetyl-coenzyme A carboxylase (ACC), reduced ACC phosphorylation status, and dramatically increased hepatic malonyl-CoA concentration. This study is the first to show that the sudden cessation of daily exercise in a hyperphagic/obese model activates a subgroup of precursors and processes known to initiate hepatic steatosis, including decreased hepatic mitochondrial oxidative capacity, increased hepatic expression of de novo lipogenesis proteins, and increased hepatic malonyl CoA levels; each probably increasing the susceptibility to non-alcoholic fatty liver disease.

  8. Dramatic variability of the carbonate system of the coastal ocean is regulated by physical and biogeochemical processes on multiple timescales

    Science.gov (United States)

    Johnson, Z. I.; Hunt, D.

    2013-12-01

    Increased atmospheric carbon dioxide (CO2) from anthropogenic sources is acidifying marine environments with potentially dramatic implications for the physical, chemical and biological functioning of these ecosystems. If current trends continue, mean ocean pH is expected to decrease by ~0.2 units over the next ~50 years. Yet, at the same time there is substantial spatial and temporal variability in pH and other carbon system parameters in the ocean resulting in regions that already exceed long term projected pH changes, suggesting that short-term variability is an important layer of complexity on top of long term acidification. Thus, in order to develop predictions of future climate change impacts including ocean acidification, there is a critical need to characterize the natural range and variability of the marine CO2 system and the mechanisms responsible for this variability. Here we examine pH and dissolved inorganic carbon (DIC) variability at time intervals spanning 1 hour to >1 year in a dynamic coastal marine system to quantify variability of the carbon system at multiple time scales. Daily and seasonal variability of the carbon system is largely driven by temperature, alkalinity and the balance between primary production and respiration, but high frequency variability (hours to days) is further influenced by water mass movement (e.g. tides) and stochastic events (e.g. storms). Both annual variability (~0.3 units) and diurnal variability (~0.1 units) in coastal ocean acidity are similar in magnitude to long term projections associated with increasing atmospheric CO2 and their drivers highlight the importance of characterizing the complete carbonate system (and not just pH). Short term variability of ocean carbon parameters may already exert significant pressure on some coastal marine ecosystems with implications for ecology, biogeochemistry and evolution and this shorter term variability layers additive effects and complexity, including extreme values, on

  9. Association Between Patient- Centered Medical Home Features and Satisfaction With Family Medicine Residency Training in the US.

    Science.gov (United States)

    Carney, Patricia A; Waller, Elaine; Dexter, Eve; Marino, Miguel; Rosener, Stephanie E; Green, Larry A; Jones, Geoffrey; M Keister, J Drew; Dostal, Julie A; Jones, Samuel M; Eiff, M Patrice

    2016-11-01

    Primary care residencies are undergoing dramatic changes because of changing health care systems and evolving demands for updated training models. We examined the relationships between residents' exposures to patient-centered medical home (PCMH) features in their assigned continuity clinics and their satisfaction with training. Longitudinal surveys were collected annually from residents evaluating satisfaction with training using a 5-point Likert-type scale (1=very unsatisfied to 5=very satisfied) from 2007 through 2011, and the presence or absence of PCMH features were collected from 24 continuity clinics during the same time period. Odds ratios on residents' overall satisfaction were compared according to whether they had no exposure to PCMH features, some exposure (1-2 years), or full exposure (all 3 or more years). Fourteen programs and 690 unique residents provided data to this study. Resident satisfaction with training was highest with full exposure for integrated case management compared to no exposure, which occurred in 2010 (OR=2.85, 95% CI=1.40, 5.80). Resident satisfaction was consistently statistically lower with any or full exposure (versus none) to expanded clinic hours in 2007 and 2009 (eg, OR for some exposure in 2009 was 0.31 95% CI=0.19, 0.51, and OR for full exposure 0.28 95% CI=0.16, 0.49). Resident satisfaction for many electronic health record (EHR)-based features tended to be significantly lower with any exposure (some or full) versus no exposure over the study period. For example, the odds ratio for resident satisfaction was significantly lower with any exposure to electronic health records in continuity practice in 2008, 2009, and 2010 (OR for some exposure in 2008 was 0.36; 95% CI=0.19, 0.70, with comparable results in 2009, 2010). Resident satisfaction with training was inconsistently correlated with exposure to features of PCMH. No correlation between PCMH exposure and resident satisfaction was sustained over time.

  10. Features of MCNP6

    Science.gov (United States)

    Goorley, T.; James, M.; Booth, T.; Brown, F.; Bull, J.; Cox, L. J.; Durkee, J.; Elson, J.; Fensin, M.; Forster, R. A.; Hendricks, J.; Hughes, H. G.; Johns, R.; Kiedrowski, B.; Martz, R.; Mashnik, S.; McKinney, G.; Pelowitz, D.; Prael, R.; Sweezy, J.; Waters, L.; Wilcox, T.; Zukaitis, T.

    2014-06-01

    MCNP6 is simply and accurately described as the merger of MCNP5 and MCNPX capabilities, but it is much more than the sum of these two computer codes. MCNP6 is the result of six years of effort by the MCNP5 and MCNPX code development teams. These groups of people, residing in Los Alamos National Laboratory's X Computational Physics Division, Monte Carlo Codes Group (XCP-3) and Nuclear Engineering and Nonproliferation Division, Radiation Transport Modeling Team (NEN-5) respectively, have combined their code development efforts to produce the next evolution of MCNP. While maintenance and major bug fixes will continue for MCNP5 1.60 and MCNPX 2.7.0 for upcoming years, new code development capabilities only will be developed and released in MCNP6. In fact, the initial release of MCNP6 contains numerous new features not previously found in either code. These new features are summarized in this document. Packaged with MCNP6 is also the new production release of the ENDF/B-VII.1 nuclear data files usable by MCNP. The high quality of the overall merged code, usefulness of these new features, along with the desire in the user community to start using the merged code, have led us to make the first MCNP6 production release: MCNP6 version 1. High confidence in the MCNP6 code is based on its performance with the verification and validation test suites, comparisons to its predecessor codes, our automated nightly software debugger tests, the underlying high quality nuclear and atomic databases, and significant testing by many beta testers.

  11. Constraint-based feature validation

    NARCIS (Netherlands)

    Dohmen, M.H.P.J.

    1998-01-01

    The feature modeling paradigm combines geometric and functional product information in one model. In an ideal product development environment, multiple views of a product in terms of features coexist. Feature validation concerns the validity of the feature information in all these views, focusing on

  12. The Accelerated Learning Program: Throwing Open the Gates

    Science.gov (United States)

    Adams, Peter; Gearhart, Sarah; Miller, Robert; Roberts, Anne

    2009-01-01

    This article reports on the Accelerated Learning Program (ALP), a new model of basic writing that has produced dramatic successes for the basic writing program at the Community College of Baltimore County. Borrowing from mainstreaming programs, studio courses, fast track programs, and learning communities, ALP, for four consecutive semesters, has…

  13. Linear Projective Program Syntax

    NARCIS (Netherlands)

    Bergstra, J.A.; Bethke, I.

    2004-01-01

    Based on an extremely simple program notation more advanced program features can be developed in linear projective program syntax such as conditional statements, while loops, recursion, use of an evaluation stack, object classes, method calls etc. Taking care of a cumulative and bottom up

  14. Programming Algol

    CERN Document Server

    Malcolme-Lawes, D J

    2014-01-01

    Programming - ALGOL describes the basics of computer programming using Algol. Commands that could be added to Algol and could increase its scope are described, including multiplication and division and the use of brackets. The idea of labeling or naming a command is also explained, along with a command allowing two alternative results. Most of the important features of Algol syntax are discussed, and examples of compound statements (that is, sets of commands enclosed by a begin ... end command) are given.Comprised of 11 chapters, this book begins with an introduction to the digital computer an

  15. Why did watermills not have a dramatic effect on the Anthropocene sediment record of the Zwalm River, Belgium?

    Science.gov (United States)

    Notebaert, Bastiaan; D'Haese, Wouter

    2016-04-01

    Different studies demonstrated the dramatic effects of watermills on fluvial geomorphology in the Eastern US. Damming of floodplains and milldam lakes increased sediment deposition. Several authors attribute most of the so called post settlement legacy sediment to those milldam lakes. In Europe the role of milldams in the anthropogenic increased floodplain deposition rates during the last 1000 to 2000 years has gotten little attention until now. Therefore we studied the influence of watermills on Holocene floodplain deposition in the Zwalm catchment, Belgium. The Zwalm River is located in western part of the Belgian loess belt in an undulating landscape that had intensive agriculture for most of the last 2000 years. In total 9 watermills were present along the 17 km long main channel during the 19th century, while many were also present on tributaries. Historical records date several of the mills to the 10th century AD, although they might be older, and most of them remain to some degree active today. The influence of watermills on floodplain deposits was tested through coring transects of the Holocene deposits. Detailed transects were performed pairwise upstream and downstream 5 watermills. Samples were taken for grain size analysis using laser diffraction. A possible influence on floodplain topography was tested on a 5 m resolution DTM. Holocene floodplain architecture is similar to other floodplains in the region: a basal early to mid-Holocene peat and gyttja layer is covered by a fine grained sediment layer of more than 5 m thickness. The change between both can be attributed to increased soil erosion due to human land use, and can be considered to be the local legacy sediment. Comparison of transects upstream and downstream mills shows no significant difference in total Holocene or legacy sediment thickness. Texture analysis indicates that floodplain sediments are significant coarser downstream the mills.F Floodplains are not significant steeper around mills

  16. Integrating Microcomputing into Preparation Programs.

    Science.gov (United States)

    Peseau, Bruce A.

    This paper presents an example of a course syllabus that integrates the use of microcomputers as part of a recommendation that administrators become specialists in microcomputing in their preparatory programs. Computers' dramatically reduced costs, in combination with increased power, has made them easily available in the form of microcomputers.…

  17. Features or tasks?

    DEFF Research Database (Denmark)

    Heilesen, Simon

    In this paper for the Workshop on Human-computer interaction and e-learning, NordiCHI 2002, the author argues that in developing innovative E-learning systems, especially if constructivist pedagogy is to be applied, it will be useful to model the user interface on the often complex tasks that the...... that the user has to perform rather than just focusing on technical features (and adapting system use to them).......In this paper for the Workshop on Human-computer interaction and e-learning, NordiCHI 2002, the author argues that in developing innovative E-learning systems, especially if constructivist pedagogy is to be applied, it will be useful to model the user interface on the often complex tasks...

  18. Genomic Feature Models

    DEFF Research Database (Denmark)

    Sørensen, Peter; Edwards, Stefan McKinnon; Rohde, Palle Duun

    Whole-genome sequences and multiple trait phenotypes from large numbers of individuals will soon be available in many populations. Well established statistical modeling approaches enable the genetic analyses of complex trait phenotypes while accounting for a variety of additive and non......-additive genetic mechanisms. These modeling approaches have proven to be highly useful to determine population genetic parameters as well as prediction of genetic risk or value. We present a series of statistical modelling approaches that use prior biological information for evaluating the collective action...... of sets of genetic variants. We have applied these approaches to whole genome sequences and a complex trait phenotype resistance to starvation collected on inbred lines from the Drosophila Genome Reference Panel population. We identified a number of genomic features classification schemes (e.g. prior QTL...

  19. Abdominal tuberculosis: Imaging features

    Energy Technology Data Exchange (ETDEWEB)

    Pereira, Jose M. [Department of Radiology, Hospital de S. Joao, Porto (Portugal)]. E-mail: jmpjesus@yahoo.com; Madureira, Antonio J. [Department of Radiology, Hospital de S. Joao, Porto (Portugal); Vieira, Alberto [Department of Radiology, Hospital de S. Joao, Porto (Portugal); Ramos, Isabel [Department of Radiology, Hospital de S. Joao, Porto (Portugal)

    2005-08-01

    Radiological findings of abdominal tuberculosis can mimic those of many different diseases. A high level of suspicion is required, especially in high-risk population. In this article, we will describe barium studies, ultrasound (US) and computed tomography (CT) findings of abdominal tuberculosis (TB), with emphasis in the latest. We will illustrate CT findings that can help in the diagnosis of abdominal tuberculosis and describe imaging features that differentiate it from other inflammatory and neoplastic diseases, particularly lymphoma and Crohn's disease. As tuberculosis can affect any organ in the abdomen, emphasis is placed to ileocecal involvement, lymphadenopathy, peritonitis and solid organ disease (liver, spleen and pancreas). A positive culture or hystologic analysis of biopsy is still required in many patients for definitive diagnosis. Learning objectives:1.To review the relevant pathophysiology of abdominal tuberculosis. 2.Illustrate CT findings that can help in the diagnosis.

  20. [MRI features of neurosyphilis].

    Science.gov (United States)

    Brisset, M; Chadenat, M L; Cordoliani, Y; Kamga-Tallom, R; D'Anglejean, J; Pico, F

    2011-04-01

    Neurosyphilis is rare today. It arises on average 20 years after poorly treated or untreated primary syphilis. Considering the decline in the incidence of syphilitic meningo encephalitis and the little known MRI aspects, we report the case of a patient affected by neurosyphilis occurring after primary syphilis untreated for 25 years. A 65-year-old man presented typical clinical features including general paresis with psychiatric disorders, maniac access, and frontal syndrome as well as tabes dorsalis and Argyll-Robertson pupil. Brain MRI showed bilateral high intensity signals on the T2 weighted sequence located in mesiotemporal, insular, frontal regions. Very few cases of neurosyphilis with detailed brain MRI aspects have been reported. The interest of this case report is first to recall the importance of syphilitic serology in patients with subacute psychiatric disorders and secondly to present rarely reported aspects of the brain MRI. Copyright © 2011. Published by Elsevier Masson SAS.

  1. Dependency Parsing with Transformed Feature

    Directory of Open Access Journals (Sweden)

    Fuxiang Wu

    2017-01-01

    Full Text Available Dependency parsing is an important subtask of natural language processing. In this paper, we propose an embedding feature transforming method for graph-based parsing, transform-based parsing, which directly utilizes the inner similarity of the features to extract information from all feature strings including the un-indexed strings and alleviate the feature sparse problem. The model transforms the extracted features to transformed features via applying a feature weight matrix, which consists of similarities between the feature strings. Since the matrix is usually rank-deficient because of similar feature strings, it would influence the strength of constraints. However, it is proven that the duplicate transformed features do not degrade the optimization algorithm: the margin infused relaxed algorithm. Moreover, this problem can be alleviated by reducing the number of the nearest transformed features of a feature. In addition, to further improve the parsing accuracy, a fusion parser is introduced to integrate transformed and original features. Our experiments verify that both transform-based and fusion parser improve the parsing accuracy compared to the corresponding feature-based parser.

  2. Dramatic reduction of dislocations on a GaN point seed crystal by coalescence of bunched steps during Na-flux growth

    Science.gov (United States)

    Imanishi, Masayuki; Todoroki, Yuma; Murakami, Kosuke; Matsuo, Daisuke; Imabayashi, Hiroki; Takazawa, Hideo; Maruyama, Mihoko; Imade, Mamoru; Yoshimura, Masashi; Mori, Yusuke

    2015-10-01

    In our study, we found that threading dislocation density (TDD) in GaN crystals naturally reduced from ~109 cm-2 in a seed to less than ~103 cm-2, just by using the small-sized seed called a "point seed". However, the mechanism of the dramatic reduction was unclear. In order to reveal the mechanism of this substantial reduction of TDD, we investigated the relationship between TDD and the crystal habit during the growth. Cathodoluminescence (CL) and scanning electron microscopy (SEM) images showed that TDD was dramatically reduced after the c face became small (dislocations (TDs), and resulted in the dramatic reduction of TDD. We concluded that the natural reduction of TDs was caused by coalescence of bunched steps, which easily occurs in during the Na-flux growth on small-sized "point seeds", and which allowed fabrication of low-dislocation-density GaN wafers.

  3. C++ Programming Language

    Science.gov (United States)

    Shaykhian, Gholam Ali

    2007-01-01

    C++ Programming Language: The C++ seminar covers the fundamentals of C++ programming language. The C++ fundamentals are grouped into three parts where each part includes both concept and programming examples aimed at for hands-on practice. The first part covers the functional aspect of C++ programming language with emphasis on function parameters and efficient memory utilization. The second part covers the essential framework of C++ programming language, the object-oriented aspects. Information necessary to evaluate various features of object-oriented programming; including encapsulation, polymorphism and inheritance will be discussed. The last part of the seminar covers template and generic programming. Examples include both user defined and standard templates.

  4. A prototype feature system for feature retrieval using relationships

    Science.gov (United States)

    Choi, J.; Usery, E.L.

    2009-01-01

    Using a feature data model, geographic phenomena can be represented effectively by integrating space, theme, and time. This paper extends and implements a feature data model that supports query and visualization of geographic features using their non-spatial and temporal relationships. A prototype feature-oriented geographic information system (FOGIS) is then developed and storage of features named Feature Database is designed. Buildings from the U.S. Marine Corps Base, Camp Lejeune, North Carolina and subways in Chicago, Illinois are used to test the developed system. The results of the applications show the strength of the feature data model and the developed system 'FOGIS' when they utilize non-spatial and temporal relationships in order to retrieve and visualize individual features.

  5. In Brief: Online Arctic mapping feature unveiled

    Science.gov (United States)

    Kumar, Mohi

    2007-08-01

    The Arctic Research Mapping Application (ARMAP), a Web portal of interactive maps and services, can now be used in conjunction with Google Earth. The new feature allows users to readily interface between satellite images, road and political maps, and other baseline information. ARMAP (see http://armap.org) supports Arctic science with special emphasis on promoting the current International Polar Year and is funded by the National Science Foundation's Office of Polar Programs.

  6. Meta-Level Runtime Feature Awareness for Java

    DEFF Research Database (Denmark)

    Olszak, Andrzej; Jensen, Martin Lykke Rytter; Jørgensen, Bo Nørregaard

    2011-01-01

    introduce the concept of runtime feature awareness that enables a running program to establish and make use of its own feature-code traceability links. We present an implementation of this idea, a dynamic-analysis Java library called JAwareness. JAwareness provides a meta-level architecture that can be non...

  7. Fluorides in dental public health programs.

    Science.gov (United States)

    Kumar, Jayanth V; Moss, Mark E

    2008-04-01

    The use of fluorides in dental public health programs has a long history. With the availability of fluoridation and other forms of fluorides, dental caries have declined dramatically in the United States. This article reviews some of the ways fluorides are used in public health programs and discusses issues related to their effectiveness, cost, and policy.

  8. Featured Image: Structures in the Interstellar Medium

    Science.gov (United States)

    Kohler, Susanna

    2017-02-01

    This beautiful false-color image (which covers 57 degrees2; click for the full view!) reveals structures in the hydrogen gas that makes up the diffuse atomic interstellar medium at intermediate latitudes in our galaxy. The imagewas created by representing three velocity channels with colors red for gas moving at 7.59 km/s, green for 5.12 km/s, and blue for 2.64 km/s and it shows the dramatically turbulent and filamentary structure of this gas. This image is one of many stunning, high-resolution observations that came out of the DRAO HI Intermediate Galactic Latitude Survey, a program that used the Synthesis Telescope at the Dominion Radio Astrophysical Observatory in British Columbia to map faint hydrogen emission at intermediate latitudes in the Milky Way. The findings from the program were recently published in a study led by Kevin Blagrave (Canadian Institute for Theoretical Astrophysics, University of Toronto); to find out more about what they learned, check out the paper below!CitationK. Blagrave et al 2017 ApJ 834 126. doi:10.3847/1538-4357/834/2/126

  9. Pharmacological features of osthole.

    Science.gov (United States)

    Jarząb, Agata; Grabarska, Aneta; Skalicka-Woźniak, Krystyna; Stepulak, Andrzej

    2017-05-15

    Coumarins are a group of naturally occurring compounds common in the plant world. These substances and their derivatives exhibit a broad range of biological activities. One of the naturally occurring coumarins is osthole, which can most frequently be found in plants of the Apiaceae family. Cnidium monnieri (L.) Cusson ex Juss. Angelica pubescens Maxim. and Peucedanum ostruthium (L.). It has anti-proliferative, anti-inflammatory, anti-convulsant, and antiallergic properties; apart from that, inhibition of platelet aggregation has also been proved. The impact of osthole on bone metabolism has been demonstrated; also its hepatoprotective and neuroprotective properties have been confirmed. The inhibitory effect of this metokcompound on the development of neurodegenerative diseases has been proved in experimental models. Anticancer features of osthole have been also demonstrated both in vitro on different cell lines, and in vivo using animals xenografts. Osthole inhibited proliferation, motility and invasiveness of tumor cells, which may be associated with the induction of apoptosis and cell cycle slowdown. The exact molecular mechanism of osthole anti-cancer mode of action has not been fully elucidated. A synergistic effect of osthole with other anti-tumor substances has been also reported. Modification of its chemical structure led to the synthesis of many derivatives with significant anticancer effects. To sum up, osthole is an interesting therapeutic option, due to both its direct effect on tumor cells, as well as its neuroprotective or anti-inflammatory properties. Thus, there is a chance to use osthole or its synthetic derivatives in the treatment of cancer.

  10. Use a Checklist for Features.

    Science.gov (United States)

    Seeger, Arthur

    1986-01-01

    Notes that the ways in which feature stories "go wrong" tend to cluster into patterns, and presents a classroom developed list of tag-words and one-line definitions for marking feature assignments and use in group critiques. (HTH)

  11. SOUND MORPHING BY FEATURE INTERPOLATION

    OpenAIRE

    Freitas Caetano, Marcelo; Rodet, Xavier

    2011-01-01

    International audience; The goal of sound morphing by feature interpolation is to obtain sounds whose values of features are intermediate between those of the source and target sounds. In order to do this, we should be able to resynthesize sounds that present a set of predefined feature values, a notoriously difficult problem. In this work, we present morphing techniques to obtain hybrid musical instrument sounds whose feature values correspond as close as possible to the ideal interpolated v...

  12. Public Relations for Invisible Programs.

    Science.gov (United States)

    Pucciani, Linda

    1983-01-01

    The positive features of nonperformance programs such as general music and music appreciation should be communicated often and effectively to the community. There are many effective publicity media appropriate for nonperformance programs. (AM)

  13. Finding phonological features in perception

    NARCIS (Netherlands)

    Chládková, K.

    2014-01-01

    This thesis investigated whether phonological features have perceptual bases. The search for features in perception was approached from several angles: from that of an adult listener who has a fully acquired language system in place, from that of a linguist who aims to uncover feature structures in

  14. Pharmacological features of osthole

    Directory of Open Access Journals (Sweden)

    Agata Jarząb

    2017-05-01

    Full Text Available Coumarins are a group of naturally occurring compounds common in the plant world. These substances and their derivatives exhibit a broad range of biological activities.One of the naturally occurring coumarins is osthole, which can most frequently be found in plants of the Apiaceae family. Cnidium monnieri (L. Cusson ex Juss. Angelica pubescens Maxim. and Peucedanum ostruthium (L.. It has anti-proliferative, anti-inflammatory, anti-convulsant, and antiallergic properties; apart from that, inhibition of platelet aggregation has also been proved. The impact of osthole on bone metabolism has been demonstrated; also its hepatoprotective and neuroprotective properties have been confirmed. The inhibitory effect of this metokcompound on the development of neurodegenerative diseases has been proved in experimental models. Anticancer features of osthole have been also demonstrated both in vitro on different cell lines, and in vivo using animals xenografts. Osthole inhibited proliferation, motility and invasiveness of tumor cells, which may be associated with the induction of apoptosis and cell cycle slowdown. The exact molecular mechanism of osthole anti-cancer mode of action has not been fully elucidated. A synergistic effect of osthole with other anti-tumor substances has been also reported. Modification of its chemical structure led to the synthesis of many derivatives with significant anticancer effects.To sum up, osthole is an interesting therapeutic option, due to both its direct effect on tumor cells, as well as its neuroprotective or anti-inflammatory properties. Thus, there is a chance to use osthole or its synthetic derivatives in the treatment of cancer.

  15. Design-based texture feature fusion using Gabor filters and co-occurrence probabilities.

    Science.gov (United States)

    Clausi, David A; Deng, Huang

    2005-07-01

    A design-based method to fuse Gabor filter and grey level co-occurrence probability (GLCP) features for improved texture recognition is presented. The fused feature set utilizes both the Gabor filter's capability of accurately capturing lower and mid-frequency texture information and the GLCP's capability in texture information relevant to higher frequency components. Evaluation methods include comparing feature space separability and comparing image segmentation classification rates. The fused feature sets are demonstrated to produce higher feature space separations, as well as higher segmentation accuracies relative to the individual feature sets. Fused feature sets also outperform individual feature sets for noisy images, across different noise magnitudes. The curse of dimensionality is demonstrated not to affect segmentation using the proposed the 48-dimensional fused feature set. Gabor magnitude responses produce higher segmentation accuracies than linearly normalized Gabor magnitude responses. Feature reduction using principal component analysis is acceptable for maintaining the segmentation performance, but feature reduction using the feature contrast method dramatically reduced the segmentation accuracy. Overall, the designed fused feature set is advocated as a means for improving texture segmentation performance.

  16. Films of Transition Metal Complexes Including Ionic Liquids: Dramatic Effects of Processing Parameters and Substrate on the Film Morphology

    Science.gov (United States)

    Bayatpour, Sareh; Isik, Dilek; Santato, Clara

    2018-01-01

    Bis(2-phenylpyridine- C, N)(2,2'-bipyridine- N, N') iridium(III) hexafluorophosphate ([Ir(ppy)2(bpy)][PF6]) is an ionic transition-metal complex (iTMC) of interest for use in light-emitting electrochemical cells (LEECs). Films of [Ir(ppy)2(bpy)][PF6] blended with the ionic liquid 1-butyl-3-methylimidazolium hexafluorophosphate ([BMIm][PF6]), deposited on different substrates, have been investigated for their morphological features, which are expected to affect the functional properties of the films, e.g., charge carrier transport. In literature, ionic liquids have been included in films of transition-metal complexes (TMCs) to increase the ion mobility and improve the performance of LEECs. A systematic comparison between the morphology of pure [Ir(ppy)2(bpy)][PF6] films and [Ir(ppy)2(bpy)][PF6] films containing [BMIm][PF6] has been carried out on different types of substrate, namely Au-patterned SiO2, indium tin oxide (ITO), and poly(3,4-ethylenedioxythiophene):polystyrene sulfonate (PEDOT:PSS)-modified ITO. Although [Ir(ppy)2(bpy)][PF6] forms smooth films on SiO2, ITO, and PEDOT:PSS-modified ITO substrates, addition of [BMIm][PF6] caused formation of vertical, discontinuous aggregates, which are expected to be detrimental to charge transport in LEECs with planar architecture.

  17. Point Mutation in the Stalk of Angiotensin-Converting Enzyme Causes a Dramatic Increase in Serum Angiotensin-Converting Enzyme But No Cardiovascular Disease

    NARCIS (Netherlands)

    C. Kramers; S.M. Danilov; J. Deinum (Jacob); I.V. Balvasnikova; N. Scharenborg; M. Looman; M.B. de Keijzer; C.M. van Duijn (Cornelia); S. Martin (Sandra); F. Soubrier; G.J. Adema (Gosse J.); F. Boomsma (Frans)

    2001-01-01

    textabstractBACKGROUND: Angiotensin-converting enzyme (ACE) metabolizes many small peptides and plays a key role in blood pressure regulation. Elevated serum ACE is claimed to be associated with an increased risk for cardiovascular disease. Previously, two families with dramatically increased serum

  18. Point mutation in the stalk of angiotensin-converting enzyme causes a dramatic increase in serum angiotensin-converting enzyme but no cardiovascular disease.

    NARCIS (Netherlands)

    Kramers, C.; Danilov, S.M.; Deinum, J.; Balyasnikova, I.V.; Scharenborg, N.M.; Looman, M.W.G.; Boomsma, F.; Keijzer, M.H. de; Duijn, C.M. van; Martin, S.; Soubrier, F.; Adema, G.J.

    2001-01-01

    BACKGROUND: Angiotensin-converting enzyme (ACE) metabolizes many small peptides and plays a key role in blood pressure regulation. Elevated serum ACE is claimed to be associated with an increased risk for cardiovascular disease. Previously, two families with dramatically increased serum ACE were

  19. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Safety Conference ACS Clinical Scholars in Residence Clinical Trials Methods Course Health Services Research Methods Course Surgeon ... Institute Featured Articles Nora Institute Mission The FIRST Trial Advocacy Advocacy Overview Quality Payment Program QPP Resource ...

  20. Geophysical Features - STRUCTURAL_FEATURES_IN: Structural Features of Indiana (Indiana Geological Survey, Line Shapefile)

    Data.gov (United States)

    NSGIC State | GIS Inventory — STRUCTURAL_FEATURES_IN is a line shapefile that shows the location of known structural features in Indiana; source data scales range from 1:12,000 to 1:500,000 (only...

  1. Confidence-Based Feature Acquisition

    Science.gov (United States)

    Wagstaff, Kiri L.; desJardins, Marie; MacGlashan, James

    2010-01-01

    Confidence-based Feature Acquisition (CFA) is a novel, supervised learning method for acquiring missing feature values when there is missing data at both training (learning) and test (deployment) time. To train a machine learning classifier, data is encoded with a series of input features describing each item. In some applications, the training data may have missing values for some of the features, which can be acquired at a given cost. A relevant JPL example is that of the Mars rover exploration in which the features are obtained from a variety of different instruments, with different power consumption and integration time costs. The challenge is to decide which features will lead to increased classification performance and are therefore worth acquiring (paying the cost). To solve this problem, CFA, which is made up of two algorithms (CFA-train and CFA-predict), has been designed to greedily minimize total acquisition cost (during training and testing) while aiming for a specific accuracy level (specified as a confidence threshold). With this method, it is assumed that there is a nonempty subset of features that are free; that is, every instance in the data set includes these features initially for zero cost. It is also assumed that the feature acquisition (FA) cost associated with each feature is known in advance, and that the FA cost for a given feature is the same for all instances. Finally, CFA requires that the base-level classifiers produce not only a classification, but also a confidence (or posterior probability).

  2. Feature++: Automatic Feature Construction for Clinical Data Analysis.

    Science.gov (United States)

    Sun, Wen; Hao, Bibo; Yu, Yiqin; Li, Jing; Hu, Gang; Xie, Guotong

    2016-01-01

    With the rapid growth of clinical data and knowledge, feature construction for clinical analysis becomes increasingly important and challenging. Given a clinical dataset with up to hundreds or thousands of columns, the traditional manual feature construction process is usually too labour intensive to generate a full spectrum of features with potential values. As a result, advanced large-scale data analysis technologies, such as feature selection for predictive modelling, cannot be fully utilized for clinical data analysis. In this paper, we propose an automatic feature construction framework for clinical data analysis, namely, Feature++. It leverages available public knowledge to understand the semantics of the clinical data, and is able to integrate external data sources to automatically construct new features based on predefined rules and clinical knowledge. We demonstrate the effectiveness of Feature++ in a typical predictive modelling use case with a public clinical dataset, and the results suggest that the proposed approach is able to fulfil typical feature construction tasks with minimal dataset specific configurations, so that more accurate models can be obtained from various clinical datasets in a more efficient way.

  3. Complex Topographic Feature Ontology Patterns

    Science.gov (United States)

    Varanka, Dalia E.; Jerris, Thomas J.

    2015-01-01

    Semantic ontologies are examined as effective data models for the representation of complex topographic feature types. Complex feature types are viewed as integrated relations between basic features for a basic purpose. In the context of topographic science, such component assemblages are supported by resource systems and found on the local landscape. Ontologies are organized within six thematic modules of a domain ontology called Topography that includes within its sphere basic feature types, resource systems, and landscape types. Context is constructed not only as a spatial and temporal setting, but a setting also based on environmental processes. Types of spatial relations that exist between components include location, generative processes, and description. An example is offered in a complex feature type ‘mine.’ The identification and extraction of complex feature types are an area for future research.

  4. What Makes a Good Feature?

    Science.gov (United States)

    1992-04-01

    RICHARDS & JEPSON WHAT MAKES A GOOD FEATURE? MACHINE NEUROPHYSIOLOGY ETHOLOGY VISION ze7-crossing V - Duck parallel T - junction H owlnd sk w-y...metry F= 9e Figure 1 Typical features proposed by machine vision, neurophysiology, and ethology . What common properties do these features satisfy? What...transversal cat - egory Pi within M. Each of these measures is assumed to have density functions of the form p,(mIC.) = pC(m)fCexp(-H,(mjC.)),i = 0

  5. Feature selection using feature dissimilarity measure and density ...

    Indian Academy of Sciences (India)

    2015-09-28

    Sep 28, 2015 ... 2009]). Classification accuracies are first measured without performing any feature selection. In the case of Parkinson's,. WDBC, dermatology and colon cancer data, FSICI helps classifiers obtain the best accuracies, whereas for rest of. Table 3. Comparison results of different feature selection algorithms for ...

  6. Emergent interfaces for feature modularization

    CERN Document Server

    Ribeiro, Márcio; Brabrand, Claus

    2014-01-01

    Developers frequently introduce errors into software systems when they fail to recognise module dependencies. Using forty-three software families and Software Product Lines (SPLs), where the majority are commonly used in industrial practice, the authors reports on the feature modularization problem and provides a study of how often it may occur in practice. To solve the problem they present the concept of emergent feature modularization which aims to establish contracts between features to prevent developers from breaking other features when performing a maintenance task.

  7. Programming Pig

    CERN Document Server

    Gates, Alan

    2011-01-01

    This guide is an ideal learning tool and reference for Apache Pig, the open source engine for executing parallel data flows on Hadoop. With Pig, you can batch-process data without having to create a full-fledged application-making it easy for you to experiment with new datasets. Programming Pig introduces new users to Pig, and provides experienced users with comprehensive coverage on key features such as the Pig Latin scripting language, the Grunt shell, and User Defined Functions (UDFs) for extending Pig. If you need to analyze terabytes of data, this book shows you how to do it efficiently

  8. Cambridge-Cranfield High Performance Computing Facility (HPCF) purchases ten Sun Fire(TM) 15K servers to dramatically increase power of eScience research

    CERN Document Server

    2002-01-01

    "The Cambridge-Cranfield High Performance Computing Facility (HPCF), a collaborative environment for data and numerical intensive computing privately run by the University of Cambridge and Cranfield University, has purchased 10 Sun Fire(TM) 15K servers from Sun Microsystems, Inc.. The total investment, which includes more than $40 million in Sun technology, will dramatically increase the computing power, reliability, availability and scalability of the HPCF" (1 page).

  9. Female Listeners’ Autonomic Responses to Dramatic Shifts Between Loud and Soft Music/Sound Passages: A Study of Heavy Metal Songs

    OpenAIRE

    Cheng, Tzu-Han; Tsai, Chen-Gia

    2016-01-01

    Although music and the emotion it conveys unfold over time, little is known about how listeners respond to shifts in musical emotions. A special technique in heavy metal music utilizes dramatic shifts between loud and soft passages. Loud passages are penetrated by distorted sounds conveying aggression, whereas soft passages are often characterized by a clean, calm singing voice and light accompaniment. The present study used heavy metal songs and soft sea sounds to examine how female listener...

  10. Feature extraction using fractal codes

    NARCIS (Netherlands)

    B.A.M. Ben Schouten; Paul M. de Zeeuw

    1999-01-01

    Fast and successful searching for an object in a multimedia database is a highly desirable functionality. Several approaches to content based retrieval for multimedia databases can be found in the literature [9,10,12,14,17]. The approach we consider is feature extraction. A feature can be seen as a

  11. The Nature of Design Features

    DEFF Research Database (Denmark)

    Andreasen, Mogens Myrup; Mortensen, Niels Henrik

    1997-01-01

    In this paper it is argued that the core of design features is design characteristics, i.e. the design attributes which define the design (the result from design work) and determine the behaviour. A definition of features as relationships between product design characteristics and life phase system...

  12. Partial Epilepsy with Auditory Features

    Directory of Open Access Journals (Sweden)

    J Gordon Millichap

    2004-07-01

    Full Text Available The clinical characteristics of 53 sporadic (S cases of idiopathic partial epilepsy with auditory features (IPEAF were analyzed and compared to previously reported familial (F cases of autosomal dominant partial epilepsy with auditory features (ADPEAF in a study at the University of Bologna, Italy.

  13. Hopewell Furnace NHS Small Scale Features (Linear Features)

    Data.gov (United States)

    National Park Service, Department of the Interior — This shapefile represents the linear small scale features found at Hopewell Furnace National Historic Site based on the Cultural Landscape Report completed in...

  14. Glacial Features (Point) - Quad 168 (EPPING, NH)

    Data.gov (United States)

    University of New Hampshire — The Glacial Features (Point) layer describes point features associated with surficial geology. These glacial features include, but are not limited to, delta forsets,...

  15. Glacial Features (Point) - Quad 169 (NEWMARKET, NH)

    Data.gov (United States)

    University of New Hampshire — The Glacial Features (Point) layer describes point features associated with surficial geology. These glacial features include, but are not limited to, delta forsets,...

  16. Elementary number theory with programming

    CERN Document Server

    Lewinter, Marty

    2015-01-01

    A successful presentation of the fundamental concepts of number theory and computer programming Bridging an existing gap between mathematics and programming, Elementary Number Theory with Programming provides a unique introduction to elementary number theory with fundamental coverage of computer programming. Written by highly-qualified experts in the fields of computer science and mathematics, the book features accessible coverage for readers with various levels of experience and explores number theory in the context of programming without relying on advanced prerequisite knowledge and con

  17. Solar Features - Prominences and Filaments

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Prominences and filaments are two manifestations of the same phenomenon. Both prominences and filaments are features formed above the chromosphere by cool dense...

  18. Youth job market specific features

    Directory of Open Access Journals (Sweden)

    Evgeniya Yu. Zhuravleva

    2011-05-01

    Full Text Available The article considers youth job market peculiarities, its specific features and regulation means, determines theoretical and application tasks of qualitative and quantitative comparison of vocations, which are highly in demand at the job market.

  19. Feature-by-feature--evaluating de novo sequence assembly.

    Directory of Open Access Journals (Sweden)

    Francesco Vezzi

    Full Text Available The whole-genome sequence assembly (WGSA problem is among one of the most studied problems in computational biology. Despite the availability of a plethora of tools (i.e., assemblers, all claiming to have solved the WGSA problem, little has been done to systematically compare their accuracy and power. Traditional methods rely on standard metrics and read simulation: while on the one hand, metrics like N50 and number of contigs focus only on size without proportionately emphasizing the information about the correctness of the assembly, comparisons performed on simulated dataset, on the other hand, can be highly biased by the non-realistic assumptions in the underlying read generator. Recently the Feature Response Curve (FRC method was proposed to assess the overall assembly quality and correctness: FRC transparently captures the trade-offs between contigs' quality against their sizes. Nevertheless, the relationship among the different features and their relative importance remains unknown. In particular, FRC cannot account for the correlation among the different features. We analyzed the correlation among different features in order to better describe their relationships and their importance in gauging assembly quality and correctness. In particular, using multivariate techniques like principal and independent component analysis we were able to estimate the "excess-dimensionality" of the feature space. Moreover, principal component analysis allowed us to show how poorly the acclaimed N50 metric describes the assembly quality. Applying independent component analysis we identified a subset of features that better describe the assemblers performances. We demonstrated that by focusing on a reduced set of highly informative features we can use the FRC curve to better describe and compare the performances of different assemblers. Moreover, as a by-product of our analysis, we discovered how often evaluation based on simulated data, obtained with state

  20. Correlative feature analysis on FFDM

    Energy Technology Data Exchange (ETDEWEB)

    Yuan Yading; Giger, Maryellen L.; Li Hui; Sennett, Charlene [Department of Radiology, Committee on Medical Physics, University of Chicago, 5841 South Maryland Avenue, MC 2026 Chicago, Illinois 60637 (United States)

    2008-12-15

    Identifying the corresponding images of a lesion in different views is an essential step in improving the diagnostic ability of both radiologists and computer-aided diagnosis (CAD) systems. Because of the nonrigidity of the breasts and the 2D projective property of mammograms, this task is not trivial. In this pilot study, we present a computerized framework that differentiates between corresponding images of the same lesion in different views and noncorresponding images, i.e., images of different lesions. A dual-stage segmentation method, which employs an initial radial gradient index (RGI) based segmentation and an active contour model, is applied to extract mass lesions from the surrounding parenchyma. Then various lesion features are automatically extracted from each of the two views of each lesion to quantify the characteristics of density, size, texture and the neighborhood of the lesion, as well as its distance to the nipple. A two-step scheme is employed to estimate the probability that the two lesion images from different mammographic views are of the same physical lesion. In the first step, a correspondence metric for each pairwise feature is estimated by a Bayesian artificial neural network (BANN). Then, these pairwise correspondence metrics are combined using another BANN to yield an overall probability of correspondence. Receiver operating characteristic (ROC) analysis was used to evaluate the performance of the individual features and the selected feature subset in the task of distinguishing corresponding pairs from noncorresponding pairs. Using a FFDM database with 123 corresponding image pairs and 82 noncorresponding pairs, the distance feature yielded an area under the ROC curve (AUC) of 0.81{+-}0.02 with leave-one-out (by physical lesion) evaluation, and the feature metric subset, which included distance, gradient texture, and ROI-based correlation, yielded an AUC of 0.87{+-}0.02. The improvement by using multiple feature metrics was statistically

  1. Neutrosophic Features for Image Retrieval

    Directory of Open Access Journals (Sweden)

    A.A. Salama

    2016-12-01

    Full Text Available The goal of an Image Retrieval System is to retrieve images that are relevant to the user's request from a large image collection. In this paper, we present texture features for images embedded in the neutrosophic domain. The aim is to extract a set of features to represent the content of each image in the training database to be used for the purpose of retrieving images from the database similar to the image under consideration.

  2. FEATURES OF STUDENT PSYCHOLOGICAL COUNSELLING

    National Research Council Canada - National Science Library

    Maria Dorina Pasca

    2013-01-01

    ...), how (the problem can be solved). Some of the most important features that contribute to solving student problems are the counselor's deontology, trustworthiness and attitude that are to be relied on without impeding the client's personality traits. Thus, developing awareness of the features underlying student psychological counseling and acting accordingly is the real test for any professional in the field. Therefore, the real challenge is not being in the lion's den, but living with it.

  3. Children of the World: A Multi-Cultural Drama Program in a Multi-Cultural Environment.

    Science.gov (United States)

    Tabone, Carmine; Albrecht, Robert

    1991-01-01

    Describes an arts and drama program in New Jersey which celebrates and explores cultural diversity. Outlines the seven-week workshop series (beginning with a dramatization of the Tower of Babel myth) that introduces art, music, and traditional stories of various cultures. Concludes with a festival where children dramatize stories they have…

  4. Intravenous immunoglobulin therapy leading to dramatic improvement in a patient with systemic juvenile idiopathic arthritis and severe pericarditis resistant to steroid pulse therapy.

    Science.gov (United States)

    Aizawa-Yashiro, Tomomi; Oki, Eishin; Tsuruga, Kazushi; Nakahata, Tohru; Ito, Etsuro; Tanaka, Hiroshi

    2012-05-01

    A 7-year-old Japanese boy with a 4-month history of systemic juvenile idiopathic arthritis (s-JIA) experienced disease flare with spiking fever, exanthema and arthralgia. He then developed progressive dyspnea due to severe pericarditis, and proinflammatory hypercytokinemia was suspected. Methylprednisolone pulse therapy was ineffective and echocardiography showed massive pericardial effusion had persisted. Alternatively, subsequent intravenous immunoglobulin (IVIG) therapy resulted in dramatic resolution of the pericardial effusion, and his general condition significantly improved within a few days. This case report may lend further support the use of IVIG for selected patients with s-JIA and severe pericarditis.

  5. Idiopathic Facial Aseptic Granuloma in a 13-Year-Old Boy Dramatically Improved with Oral Doxycycline and Topical Metronidazole: Evidence for a Link with Childhood Rosacea

    Directory of Open Access Journals (Sweden)

    Camille Orion

    2016-07-01

    Full Text Available Idiopathic facial aseptic granuloma (IFAG is a rare, benign pediatric dermatological lesion that occurs in children between 8 months and 13 years of age. The pathogenesis of IFAG is still unclear but it is likely to be associated with granulomatous rosacea in childhood. Here we describe a case of IFAG in a 13-year-old boy who showed a dramatic response to oral doxycycline and topical metronidazole, which supports the hypothesis that IFAG may belong to the spectrum of rosacea.

  6. DRAMATIC LITERATURE, DIGITISATION AND CULTURAL ...

    African Journals Online (AJOL)

    Dean SPGS NAU

    Facebook, YouTube, Twitter, LinkedIn, Instagram, Whatsapp,. Hyper, Bebo and Ello, which are prevalent among the youths, attest to the global social interactions without walls. These social interactions empowered by interactive multimedia high technologies are aided by the avalanche of mobile devices like smartphones, ...

  7. Dramatic Booktalks (for the Untheatrical).

    Science.gov (United States)

    Graham, Kent W.

    1993-01-01

    A young adult librarian offers tips on book talks which exclude the use of props, costumes, or acting. Using a book's plot point to highlight one portion of a novel to convince teenagers to go to the library, check out, and read the book is explained. A model talk of "Jurassic Park" is included. (EAM)

  8. Acute and dramatic saxophone penis

    Directory of Open Access Journals (Sweden)

    Carlota Gutiérrez García-Rodrigo

    2015-01-01

    Full Text Available We present a case of intense genital swelling because of a hereditary angioedema. This rare disease should be included in the differential diagnosis of acute and asymptomatic genital edema, because it may prevent future potentially life-threatening episodes of visceral angioedema.

  9. Dramatic lives and relevant becomings

    DEFF Research Database (Denmark)

    Henriksen, Ann-Karina; Miller, Jody

    2012-01-01

    The article explores how violence works to produce young women’s precarious positions in social milieus characterized by multiple marginalization. By paying attention to the micropolitics of violent engagements we argue that violent conflicts can be viewed as strategies for escaping positions of ...

  10. Functional Programming Using F#

    DEFF Research Database (Denmark)

    Hansen, Michael Reichhardt; Rischel, Hans

    This comprehensive introduction to the principles of functional programming using F# shows how to apply basic theoretical concepts to produce succinct and elegant programs. It demonstrates the role of functional programming in a wide spectrum of applications including databases and systems....... Coverage also includes advanced features in the .NET library, the imperative features of F# and topics such as text processing, sequences, computation expressions and asynchronous computation. With a broad spectrum of examples and exercises, the book is perfect for courses in functional programming...... and for self-study. Enhancing its use as a text is an accompanying website with downloadable programs, lecture slides, a mini-projects and links to further F# sources....

  11. Postmortem imaging: MDCT features of postmortem change and decomposition.

    Science.gov (United States)

    Levy, Angela D; Harcke, Howard Theodore; Mallak, Craig T

    2010-03-01

    Multidetector computed tomography (MDCT) has emerged as an effective imaging technique to augment forensic autopsy. Postmortem change and decomposition are always present at autopsy and on postmortem MDCT because they begin to occur immediately upon death. Consequently, postmortem change and decomposition on postmortem MDCT should be recognized and not mistaken for a pathologic process or injury. Livor mortis increases the attenuation of vasculature and dependent tissues on MDCT. It may also produce a hematocrit effect with fluid levels in the large caliber blood vessels and cardiac chambers from dependent layering erythrocytes. Rigor mortis and algor mortis have no specific MDCT features. In contrast, decomposition through autolysis, putrefaction, and insect and animal predation produce dramatic alterations in the appearance of the body on MDCT. Autolysis alters the attenuation of organs. The most dramatic autolytic changes on MDCT are seen in the brain where cerebral sulci and ventricles are effaced and gray-white matter differentiation is lost almost immediately after death. Putrefaction produces a pattern of gas that begins with intravascular gas and proceeds to gaseous distension of all anatomic spaces, organs, and soft tissues. Knowledge of the spectrum of postmortem change and decomposition is an important component of postmortem MDCT interpretation.

  12. A Mixed Feature Selection Method Considering Interaction

    OpenAIRE

    Zilin Zeng; Hongjun Zhang; Rui Zhang; Youliang Zhang

    2015-01-01

    Feature interaction has gained considerable attention recently. However, many feature selection methods considering interaction are only designed for categorical features. This paper proposes a mixed feature selection algorithm based on neighborhood rough sets that can be used to search for interacting features. In this paper, feature relevance, feature redundancy, and feature interaction are defined in the framework of neighborhood rough sets, the neighborhood interaction weight factor refle...

  13. Towards a Unified Programming Language

    DEFF Research Database (Denmark)

    Madsen, Ole Lehrmann

    2000-01-01

    style and where more research is needed. In addition to traditional paradigms such as object-oriented-, imperative-functional- and logic programming, we also discuss concurrent programming and prototype-based programming. We discuss language features such as the BETA pattern construct, virtual...

  14. The CRAFT Fortran Programming Model

    Directory of Open Access Journals (Sweden)

    Douglas M. Pase

    1994-01-01

    Full Text Available Many programming models for massively parallel machines exist, and each has its advantages and disadvantages. In this article we present a programming model that combines features from other programming models that (1 can be efficiently implemented on present and future Cray Research massively parallel processor (MPP systems and (2 are useful in constructing highly parallel programs. The model supports several styles of programming: message-passing, data parallel, global address (shared data, and work-sharing. These styles may be combined within the same program. The model includes features that allow a user to define a program in terms of the behavior of the system as a whole, where the behavior of individual tasks is implicit from this systemic definition. (In general, features marked as shared are designed to support this perspective. It also supports an opposite perspective, where a program may be defined in terms of the behaviors of individual tasks, and a program is implicitly the sum of the behaviors of all tasks. (Features marked as private are designed to support this perspective. Users can exploit any combination of either set of features without ambiguity and thus are free to define a program from whatever perspective is most appropriate to the problem at hand.

  15. Programming Proficiency in One Semester: Lessons Learned

    Science.gov (United States)

    Colton, Don; Curtis, Aaron

    2010-01-01

    Programming is a fundamental skill for Information Systems and Information Technology students. It is also a subject that some students fear, avoid, fail, retake, and fail again. An effective, inexpensive, one-semester approach is presented. Early indications suggest dramatically improved student interest and performance compared to our previous…

  16. Special feature on imaging systems and techniques

    Science.gov (United States)

    Yang, Wuqiang; Giakos, George

    2013-07-01

    The IEEE International Conference on Imaging Systems and Techniques (IST'2012) was held in Manchester, UK, on 16-17 July 2012. The participants came from 26 countries or regions: Austria, Brazil, Canada, China, Denmark, France, Germany, Greece, India, Iran, Iraq, Italy, Japan, Korea, Latvia, Malaysia, Norway, Poland, Portugal, Sweden, Switzerland, Taiwan, Tunisia, UAE, UK and USA. The technical program of the conference consisted of a series of scientific and technical sessions, exploring physical principles, engineering and applications of new imaging systems and techniques, as reflected by the diversity of the submitted papers. Following a rigorous review process, a total of 123 papers were accepted, and they were organized into 30 oral presentation sessions and a poster session. In addition, six invited keynotes were arranged. The conference not only provided the participants with a unique opportunity to exchange ideas and disseminate research outcomes but also paved a way to establish global collaboration. Following the IST'2012, a total of 55 papers, which were technically extended substantially from their versions in the conference proceeding, were submitted as regular papers to this special feature of Measurement Science and Technology . Following a rigorous reviewing process, 25 papers have been finally accepted for publication in this special feature and they are organized into three categories: (1) industrial tomography, (2) imaging systems and techniques and (3) image processing. These papers not only present the latest developments in the field of imaging systems and techniques but also offer potential solutions to existing problems. We hope that this special feature provides a good reference for researchers who are active in the field and will serve as a catalyst to trigger further research. It has been our great pleasure to be the guest editors of this special feature. We would like to thank the authors for their contributions, without which it would

  17. Fat and fibre interfere with the dramatic effect that nanoemulsified d-limonene has on the heat resistance of Listeria monocytogenes.

    Science.gov (United States)

    Maté, Javier; Periago, Paula M; Ros-Chumillas, María; Grullón, Coralin; Huertas, Juan Pablo; Palop, Alfredo

    2017-04-01

    The application of d-limonene in form of nanoemulsion has been proved to reduce dramatically the thermal resistance of Listeria monocytogenes in culture media. The present research shows very promising results on the application in food products. The thermal resistance of L. monocytogenes was reduced 90 times when 0.5 mM nanoemulsified d-limonene was added to apple juice. This is the biggest reduction in the heat resistance of a microorganism caused by an antimicrobial described ever. However, no effect was found in carrot juice. A carrot juice system was prepared in an attempt to unravel which juice constituents were responsible for the lack of effect. When fat and fibre were not included in the carrot juice system formulation, the thermal resistance of L. monocytogenes was, again, dramatically reduced in presence of nanoemulsified d-limonene, so these components were shown to interfere with the effect. Once this interaction with food constituents becomes solved, the addition of nanoemulsified antimicrobials would allow to reduce greatly the intensity of the thermal treatments currently applied in the food processing industry. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

  18. Experimentación dramatúrgica en Rojas Zorrilla: alternancia y simultaneidad espacial en Los trabajos de Tobías

    Directory of Open Access Journals (Sweden)

    Rubiera Fernández, Javier

    2007-06-01

    Full Text Available This article aims to analyse the technique used by Rojas Zorilla in a religious comedy of biblical derivation to represent, in a parallel way, dramatic actions that are simultaneously developed in very separate dramatic spaces. Although basing his approach on ancient stage procedures, by combining these with modern techniques the result is of such originality that we consider it to be «experimentation». In order to properly value his creative method, a close comparison is made between the biblical narrative, a sixteenth century auto, and a comedy by Lope de Vega that address the same subject.El objetivo de este artículo es analizar la técnica empleada por Rojas Zorrilla, en una comedia religiosa de fuente bíblica, para representar de modo paralelo acciones dramáticas que se desarrollan simultáneamente en espacios dramáticos muy alejados. A pesar de basarse en procedimientos escénicos antiguos, al combinarlo con técnicas modernas el resultado es de tal originalidad que lo calificamos de «experimentación». Para valorar debidamente su modo de componer, se hace una estrecha comparación con el relato bíblico, con un auto del siglo XVI y con una comedia de Lope de Vega que tratan el mismo tema.

  19. Imaging features of constrictive pericarditis: beyond pericardial thickening

    Energy Technology Data Exchange (ETDEWEB)

    Napolitano, G.; Pressacco, J.; Paquet, E. [Dept. of Radiology, Montreal Heart Inst., Montreal, Quebec (Canada)], E-mail: napolitanog@hotmail.com

    2009-02-15

    Constrictive pericarditis is caused by adhesions between the visceral and parietal layers of the pericardium and progressive pericardial fibrosis that restricts diastolic filling of the heart. Later on, the thickened pericardium may calcify. Despite a better understanding of the pathophysiologic basis of the imaging findings in constrictive pericarditis and the recent advent of magnetic resonance imaging (MRI) technology, which has dramatically improved the visualization of the pericardium, the diagnosis of constrictive pericarditis remains a challenge in many cases. In patients with clinical suspicion of underlying constrictive pericarditis, the most important radiologic diagnostic feature is abnormal pericardial thickening, which can be shown readily by computed tomography (CT) and especially by MRI, and is highly suggestive of constrictive pericarditis. Nevertheless, a thickened pericardium does not always indicate constrictive pericarditis. Furthermore, constrictive pericarditis can occur without pericardial thickening. (author)

  20. Beyond correlation: do color features influence attention in Rainforest?

    Directory of Open Access Journals (Sweden)

    Hans-Peter eFrey

    2011-04-01

    Full Text Available Recent research indicates a direct relationship between low-level color features and visual attention under natural conditions. However, the design of these studies allows only correlational observations and no inference about mechanisms. Here we go a step further to examine the nature of the influence of color features on overt attention in an environment in which trichromatic color vision is advantageous. We recorded eye-movements of color-normal and deuteranope human participants freely viewing original and modified rainforest images. Eliminating red-green color information dramatically alters fixation behavior in color-normal participants. Changes in feature correlations and variability over subjects and conditions provide evidence for a causal effect of red-green color contrast. The effects of blue-yellow contrast are much smaller. However, globally rotating hue in color space in these images reveals a mechanism analyzing color contrast invariant of a specific axis in color space. Surprisingly, in deuteranope participants we found significantly elevated red-green contrast at fixation points, comparable to color-normal participants. Temporal analysis indicates that this is due to compensatory mechanisms acting on a slower time scale. Taken together, our results suggest that under natural conditions red-green color information contributes to overt attention at a low level (bottom-up. Nevertheless, the results of the image modifications and deuteranope participants indicate that evaluation of color information is done in a hue-invariant fashion.

  1. Feature space analysis of MRI

    Science.gov (United States)

    Soltanian-Zadeh, Hamid; Windham, Joe P.; Peck, Donald J.

    1997-04-01

    This paper presents development and performance evaluation of an MRI feature space method. The method is useful for: identification of tissue types; segmentation of tissues; and quantitative measurements on tissues, to obtain information that can be used in decision making (diagnosis, treatment planning, and evaluation of treatment). The steps of the work accomplished are as follows: (1) Four T2-weighted and two T1-weighted images (before and after injection of Gadolinium) were acquired for ten tumor patients. (2) Images were analyed by two image analysts according to the following algorithm. The intracranial brain tissues were segmented from the scalp and background. The additive noise was suppressed using a multi-dimensional non-linear edge- preserving filter which preserves partial volume information on average. Image nonuniformities were corrected using a modified lowpass filtering approach. The resulting images were used to generate and visualize an optimal feature space. Cluster centers were identified on the feature space. Then images were segmented into normal tissues and different zones of the tumor. (3) Biopsy samples were extracted from each patient and were subsequently analyzed by the pathology laboratory. (4) Image analysis results were compared to each other and to the biopsy results. Pre- and post-surgery feature spaces were also compared. The proposed algorithm made it possible to visualize the MRI feature space and to segment the image. In all cases, the operators were able to find clusters for normal and abnormal tissues. Also, clusters for different zones of the tumor were found. Based on the clusters marked for each zone, the method successfully segmented the image into normal tissues (white matter, gray matter, and CSF) and different zones of the lesion (tumor, cyst, edema, radiation necrosis, necrotic core, and infiltrated tumor). The results agreed with those obtained from the biopsy samples. Comparison of pre- to post-surgery and radiation

  2. NEWPATH: An Innovative Program to Nurture IT Entrepreneurs

    Science.gov (United States)

    Soundarajan, Neelam; Camp, Stephen M.; Lee, David; Ramnath, Rajiv; Weide, Bruce W.

    2016-01-01

    The number of freshmen interested in entrepreneurship has grown dramatically in the last few years. In response, many universities have created entrepreneurship programs, including ones focused on engineering entrepreneurship. In this paper, we report on NEWPATH, an innovative NSF-supported program at Ohio State, designed to nurture students to…

  3. Abstract: Rwanda Human Resources for Health Program: Genesis ...

    African Journals Online (AJOL)

    Abstract. Background In 2010, the Permanent Secretary of the Rwanda Ministry of Health reached out to select US schools of nursing and midwifery to request support for a program to dramatically improve nursing and midwifery education and practice. This poster described the process that led to the Rwanda HRH Program ...

  4. Cybersecurity Curriculum Development: Introducing Specialties in a Graduate Program

    Science.gov (United States)

    Bicak, Ali; Liu, Michelle; Murphy, Diane

    2015-01-01

    The cybersecurity curriculum has grown dramatically over the past decade: once it was just a couple of courses in a computer science graduate program. Today cybersecurity is introduced at the high school level, incorporated into undergraduate computer science and information systems programs, and has resulted in a variety of cybersecurity-specific…

  5. Improvements and new features in the PDF module

    Science.gov (United States)

    Norris, Andrew T.

    1995-01-01

    This viewgraph presentation discusses what models are used in this package and what their advantages and disadvantages are, how the probability density function (PDF) model is implemented and the features of the program, and what can be expected in the future from the NASA Lewis PDF code.

  6. Teaching Practices and Peer Network Features in Elementary Classrooms

    Science.gov (United States)

    Gest, Scott D.; Rodkin, Philip C.

    2011-01-01

    The long-term goal of this program of research is to clarify how teachers may influence features of peer networks that, in turn, may affect students' perceptions of social support, achievement-related beliefs and academic achievement. As a first step in this process, in this study the authors focus on identifying teaching practices that are…

  7. Domain-specific language design requires feature descriptions

    NARCIS (Netherlands)

    A. van Deursen (Arie); P. Klint (Paul)

    2001-01-01

    textabstractA domain-specific language (DSL) provides a notation tailored towards an application domain and is based on the relevant concepts and features of that domain. As such, a DSL is a means to describe and generate members of a family of programs in the domain. A prerequisite for the design

  8. Computational features of the dictionary application “TshwaneLex ...

    African Journals Online (AJOL)

    The aim of this article is to introduce and to elaborate on computational aspects of TshwaneLex, a new South African software application for dictionary compilation. A brief introduction to the lexicographic needs for such a computer program in South Africa will be given, followed by a description of the most salient features of ...

  9. Statistical features of quantum evolution

    Indian Academy of Sciences (India)

    Home; Journals; Pramana – Journal of Physics; Volume 73; Issue 2. Statistical features of ... Abstract. It is shown that the integral of the uncertainty of energy with respect to time is independent of the particular Hamiltonian of the quantum system for an arbitrary pseudo-unitary (and hence P T -) quantum evolution. The result ...

  10. Dynamic Features for Iris Recognition.

    Science.gov (United States)

    da Costa, R M; Gonzaga, A

    2012-08-01

    The human eye is sensitive to visible light. Increasing illumination on the eye causes the pupil of the eye to contract, while decreasing illumination causes the pupil to dilate. Visible light causes specular reflections inside the iris ring. On the other hand, the human retina is less sensitive to near infra-red (NIR) radiation in the wavelength range from 800 nm to 1400 nm, but iris detail can still be imaged with NIR illumination. In order to measure the dynamic movement of the human pupil and iris while keeping the light-induced reflexes from affecting the quality of the digitalized image, this paper describes a device based on the consensual reflex. This biological phenomenon contracts and dilates the two pupils synchronously when illuminating one of the eyes by visible light. In this paper, we propose to capture images of the pupil of one eye using NIR illumination while illuminating the other eye using a visible-light pulse. This new approach extracts iris features called "dynamic features (DFs)." This innovative methodology proposes the extraction of information about the way the human eye reacts to light, and to use such information for biometric recognition purposes. The results demonstrate that these features are discriminating features, and, even using the Euclidean distance measure, an average accuracy of recognition of 99.1% was obtained. The proposed methodology has the potential to be "fraud-proof," because these DFs can only be extracted from living irises.

  11. Features Related to Faunal Activity

    NARCIS (Netherlands)

    Kooistra, M.J.; Pulleman, M.M.

    2010-01-01

    Soil fauna plays an important role in transporting and altering various soil components, in particular the decomposition of organic matter and the development of soil structure. Fauna-induced features are found in all types of soils and can be so abundant that they determine the nature and intensity

  12. Feature Selection in Scientific Applications

    Energy Technology Data Exchange (ETDEWEB)

    Cantu-Paz, E; Newsam, S; Kamath, C

    2004-02-27

    Numerous applications of data mining to scientific data involve the induction of a classification model. In many cases, the collection of data is not performed with this task in mind, and therefore, the data might contain irrelevant or redundant features that affect negatively the accuracy of the induction algorithms. The size and dimensionality of typical scientific data make it difficult to use any available domain information to identify features that discriminate between the classes of interest. Similarly, exploratory data analysis techniques have limitations on the amount and dimensionality of the data that can be effectively processed. In this paper, we describe applications of efficient feature selection methods to data sets from astronomy, plasma physics, and remote sensing. We use variations of recently proposed filter methods as well as traditional wrapper approaches where practical. We discuss the importance of these applications, the general challenges of feature selection in scientific datasets, the strategies for success that were common among our diverse applications, and the lessons learned in solving these problems.

  13. Fractal transforms and feature invariance

    NARCIS (Netherlands)

    B.A.M. Schouten (Ben); P.M. de Zeeuw (Paul)

    2000-01-01

    htmlabstractIn this paper, fractal transforms are employed with the aim of image recognition. It is known that such transforms are highly sensitive to distortions like a small shift of an image. However, by using features based on statistics kept during the actual decomposition we can derive

  14. Features of Diphtheria in Children

    Directory of Open Access Journals (Sweden)

    O.K. Koloskova

    2014-09-01

    Full Text Available The lecture describes the etiology, epidemiology, classification and clinical features of diphtheria in children, taking into account various sites, covers the issues of diagnosis. Treatment for diphtheria in children is carried as per the order of Ministry of Healthcare of Ukraine № 354 dated July 9, 2004 in accordance with the form and severity of the disease.

  15. Feature-level domain adaptation

    DEFF Research Database (Denmark)

    Kouw, Wouter M.; Van Der Maaten, Laurens J P; Krijthe, Jesse H.

    2016-01-01

    Domain adaptation is the supervised learning setting in which the training and test data are sampled from different distributions: training data is sampled from a source domain, whilst test data is sampled from a target domain. This paper proposes and studies an approach, called feature...

  16. Faithful Contrastive Features in Learning

    Science.gov (United States)

    Tesar, Bruce

    2006-01-01

    This article pursues the idea of inferring aspects of phonological underlying forms directly from surface contrasts by looking at optimality theoretic linguistic systems (Prince & Smolensky, 1993/2004). The main result proves that linguistic systems satisfying certain conditions have the faithful contrastive feature property: Whenever 2…

  17. Goldenhar syndrome with unusual features

    Directory of Open Access Journals (Sweden)

    Mehta Bijal

    2008-01-01

    Full Text Available We report here the case of a 17 year-old girl with the classic signs of Goldenhar syndrome in the form of multiple accessory tragi, bilateral ocular dermoids, mandibular hypoplasia (micrognathia and cervical lordosis. She also had a high arched palate, gingival hypertrophy and malaligned teeth, features which are as yet unreported.

  18. Utility green pricing programs: A statistical analysis of program effectiveness

    Energy Technology Data Exchange (ETDEWEB)

    Wiser, Ryan; Olson, Scott; Bird, Lori; Swezey, Blair

    2004-02-01

    Development of renewable energy. Such programs have grown in number in recent years. The design features and effectiveness of these programs varies considerably, however, leading a variety of stakeholders to suggest specific marketing and program design features that might improve customer response and renewable energy sales. This report analyzes actual utility green pricing program data to provide further insight into which program features might help maximize both customer participation in green pricing programs and the amount of renewable energy purchased by customers in those programs. Statistical analysis is performed on both the residential and non-residential customer segments. Data comes from information gathered through a questionnaire completed for 66 utility green pricing programs in early 2003. The questionnaire specifically gathered data on residential and non-residential participation, amount of renewable energy sold, program length, the type of renewable supply used, program price/cost premiums, types of consumer research and program evaluation performed, different sign-up options available, program marketing efforts, and ancillary benefits offered to participants.

  19. Dramatic improvement in decompensated right heart failure due to severe tricuspid regurgitation following ligation of arteriovenous fistula in a renal transplant recipient.

    Science.gov (United States)

    Rao, Nitesh; Worthley, Matthew; Disney, Patrick; Faull, Randall

    2014-03-01

    Arteriovenous (AV) fistulas with high blood flow rate are necessary for adequate hemodialysis, but they can also cause significant hemodynamic changes, including raised cardiac output, left ventricular hypertrophy and occasionally overt cardiac failure (Basile et al., Nephrol Dial Transplant, 23, 2008, 282; Unger et al., Am J Transplant, 4, 2004, 2038). We now report a case of rapid and dramatic improvement in symptomatic right heart failure due to severe tricuspid regurgitation following ligation of an arteriovenous fistula. Cardiac magnetic resonance imaging (MRI) performed before and after the ligation of fistula showed striking improvement in both the tricuspid regurgitation and right ventricular dimensions, with minimal impact on left ventricular mass, size, and function. © 2013 Wiley Periodicals, Inc.

  20. The homozygous VHL(D126N) missense mutation is associated with dramatically elevated erythropoietin levels, consequent polycythemia, and early onset severe pulmonary hypertension.

    Science.gov (United States)

    Sarangi, Susmita; Lanikova, Lucie; Kapralova, Katarina; Acharya, Suchitra; Swierczek, Sabina; Lipton, Jeffrey M; Wolfe, Lawrence; Prchal, Josef T

    2014-11-01

    von Hippel-Lindau (VHL) protein is the principal negative regulator of hypoxia sensing mediated by transcription factors. Mutations in exon 3 of the VHL gene lead to Chuvash (VHL(R200W)) and Croatian (VHL(H191D)) polycythemias. Here, we describe an infant of Bangladesh ethnicity with a novel homozygous VHL(D126N) mutation with congenital polycythemia and dramatically elevated erythropoietin (EPO) levels, who developed severe fatal pulmonary hypertension. In contrast to Chuvash polycythemia, erythroid progenitors (BFU-Es) did not reveal a marked EPO hypersensitivity. Further, NF-E2 and RUNX1 transcripts that correlate with BFU-Es EPO hypersensitivity in polycythemic mutations were not elevated. © 2014 Wiley Periodicals, Inc.

  1. «Que también sé yo hacer bailes»: Lope de Vega and the dramatic dance

    Directory of Open Access Journals (Sweden)

    Francisco Sáez Raposo

    2012-12-01

    Full Text Available This paper analyzes the significance and consequences of Lope de Vega’s status as a legend when it comes to accepting his authorship of a few short plays, given that critics tend to demand extra proof in this matter, sometimes going beyond reasonable philological demands. I will also defend the idea that Lope was an author of dramatic dances, one of the subgenres which critics have always been reluctant to link with his name. To this end, I will cite evidence to prove that ‘el Fénix’ not only felt an interest in these sort of plays but also composed some which were staged in courtly performances in the early 1630s.

  2. Dramatic change in a young woman's perception of her diabetes and remarkable reduction in HbA1c after an individual course of Guided Self-Determination

    DEFF Research Database (Denmark)

    Zoffmann, Vibeke; Prip, Anne; Christiansen, Anette Wendelboe

    2015-01-01

    A 24-year-old woman with type 1 diabetes participated in a randomised controlled trial proving effectiveness of a flexible Guided Self-Determination (GSD) intervention. She had for 10 years been living with a complex situation of eating disorder, poor glycaemic control, non-attendance and psychos......A 24-year-old woman with type 1 diabetes participated in a randomised controlled trial proving effectiveness of a flexible Guided Self-Determination (GSD) intervention. She had for 10 years been living with a complex situation of eating disorder, poor glycaemic control, non......-attendance and psychosocial distress. She managed to change her perception of diabetes dramatically and improved her glycaemic control. Considering the complexity of her case, we explored how she achieved these changes. A GSD-trained nurse delivered the intervention, which involves reflection sheets and advanced professional...

  3. The dramatics of the misa de amores: parody and desacralized ritual in the gestation of Spanish religious theater of the early Renaissance

    Directory of Open Access Journals (Sweden)

    Peter Cocozzella

    2016-12-01

    Full Text Available The paramount role of the mass in the birth of Spanish theater of the late Middle Ages or early Renaissance has been duly recognized by authoritative critics and historians. These scholars, however, have paid little or no attention to the centrality of the Eucharist in the gestation phase of that theater. The present essay is focused on the process of adapting the rite of transubstantiation to a dramatic plot on the way to an eventual transmutation into a full-fledged theatrical representation. At issue here are the only four extant specimens of the so-called misa de amores of the fifteenth century. These daring parodies of the Mass include Francesc Moner’s most ingenious rendition of the genre. On the basis of Linda Hutcheon’s innovative theory, one may envisage a parodic mode that conditions the distinctive traits of a “desacralized” ritual, the very matrix of the transmutation in question.

  4. Dramatic enhancement of organics degradation and electricity generation via strengthening superoxide radical by using a novel 3D AQS/PPy-GF cathode.

    Science.gov (United States)

    Zhang, Yan; Li, Jinhua; Bai, Jing; Li, Linsen; Xia, Ligang; Chen, Shuai; Zhou, Baoxue

    2017-11-15

    A dramatic enhancement of organics degradation and electricity generation has been achieved in a wastewater fuel cell (WFC) system via strengthening superoxide radical with radical chain reaction by using a novel 3D anthraquinone/polypyrrole modified graphite felt (AQS/PPy-GF) cathode. The AQS/PPy-GF was synthesized by one-pot electrochemical polymerization method and used to in-situ generate superoxide radical by reducing oxygen under self-imposed electric field. Results showed that methyl orange (MO) were effectively degraded in AQS/PPy-GF/Fe(2+) system with a high apparent rate constant (0.0677 min(-1)), which was 3.9 times that (0.0174 min(-1)) in the Pt/Fe(2+) system and even 9.4 times that (0.0072 min(-1)) in the traditional WFC system (without Fe(2+)). Meanwhile, it showed a superior performance for electricity generation and the maximum power density output (1.130 mW cm(-2)) was nearly 3.3 times and 5.0 times higher, respectively, when compared with the Pt/Fe(2+) system and traditional WFC. This dramatic advance was attributed to 3D AQS/PPy-GF cathode which produces more O2(-) via one-electron reduction process. The presence of O2(-) cannot only directly contribute to MO degradation, but also promotes the final complete mineralization by turning itself to OH. Additionally, O2(-) accelerates the Fe(2+)/Fe(3+) couple cycling, thus avoiding continuous addition of any external ferrous ions. Inhibition and probe studies were conducted to ascertain the role of several radicals (OH and O2(-)) on the MO degradation. Superoxide radicals were considered as the primary reactive oxidants, and the degradation mechanism of MO was proposed. The proposed WFC system provides a more economical and efficient way for energy recovery and wastewater treatment. Copyright © 2017 Elsevier Ltd. All rights reserved.

  5. An Angiotensin I-Converting Enzyme Mutation (Y465D) Causes a Dramatic Increase in Blood ACE via Accelerated ACE Shedding

    Science.gov (United States)

    Gordon, Kerry; Nesterovitch, Andrew B.; Lünsdorf, Heinrich; Chen, Zhenlong; Castellon, Maricela; Popova, Isolda A.; Kalinin, Sergey; Mendonca, Emma; Petukhov, Pavel A.; Schwartz, David E.

    2011-01-01

    Background Angiotensin I-converting enzyme (ACE) metabolizes a range of peptidic substrates and plays a key role in blood pressure regulation and vascular remodeling. Thus, elevated ACE levels may be associated with an increased risk for different cardiovascular or respiratory diseases. Previously, a striking familial elevation in blood ACE was explained by mutations in the ACE juxtamembrane region that enhanced the cleavage-secretion process. Recently, we found a family whose affected members had a 6-fold increase in blood ACE and a Tyr465Asp (Y465D) substitution, distal to the stalk region, in the N domain of ACE. Methodology/Principal Findings HEK and CHO cells expressing mutant (Tyr465Asp) ACE demonstrate a 3- and 8-fold increase, respectively, in the rate of ACE shedding compared to wild-type ACE. Conformational fingerprinting of mutant ACE demonstrated dramatic changes in ACE conformation in several different epitopes of ACE. Cell ELISA carried out on CHO-ACE cells also demonstrated significant changes in local ACE conformation, particularly proximal to the stalk region. However, the cleavage site of the mutant ACE - between Arg1203 and Ser1204 - was the same as that of WT ACE. The Y465D substitution is localized in the interface of the N-domain dimer (from the crystal structure) and abolishes a hydrogen bond between Tyr465 in one monomer and Asp462 in another. Conclusions/Significance The Y465D substitution results in dramatic increase in the rate of ACE shedding and is associated with significant local conformational changes in ACE. These changes could result in increased ACE dimerization and accessibility of the stalk region or the entire sACE, thus increasing the rate of cleavage by the putative ACE secretase (sheddase). PMID:21998728

  6. Research potential and cognitive features of students.

    Directory of Open Access Journals (Sweden)

    Bordovskaia N.V.

    2014-12-01

    Full Text Available This article examines the theoretical and methodological justifications for studying students’ research potential. It presents proof of the isomorphic nature of human research activity and research potential as well as of the fluid nature of its development: from research-like behavior to science-based research activity. It defines three functional components (motivational, cognitive, and behavioral that form the structure of research potential. It further presents the results of empirically studying the cognitive features of master’s students possessing different levels of research potential. It provides data on the dynamics of research-potential components at different educational levels (bachelor’s and master’s programs. Special attention is given to a comparative analysis of evaluations by research tutors regarding their students’ research potential and of the indicators obtained using psychodiagnostic methods.

  7. Clitic doubling and pure agreement person features

    Directory of Open Access Journals (Sweden)

    Ricardo Machado Rocha

    2016-03-01

    Full Text Available In this paper, we analyze clitic doubling constructions in dialectal non-standard Brazilian Portuguese. Within the Minimalism Framework, we explain very peculiar aspects of the doubled structures in this language, namely the fact that they occur only for 1st and 2nd person pronouns and that they co-vary with single clitic structures and single strong pronoun structures. Our approach assumes that the clitics me and te are hosted by a dedicated functional projection and result from the checking of the sole person feature [speaker:±]. Moreover, we show that, unlikely other cross-linguistic phenomena of pronominal doubling, Brazilian Portuguese Clitic Doubling does neither yield (nor is a result of any interpretive effect, but rather is an instance of a pure agreement chain. This leads us to advocate, contra the standard Minimalist Program, for the validity of the conceptual postulation of AgrP, as a condition on well-formedness of certain structures.

  8. Method for transforming a feature vector

    NARCIS (Netherlands)

    Veldhuis, Raymond N.J.; Chen, C.; Kevenaar, Thomas A.M.; Akkermans, Antonius H.M.

    2007-01-01

    The present invention relates to a method for transforming a feature vector comprising a first and a second feature represented by a first and a second feature value, respectively, into a feature code using an encoder, said feature code usable in an algorithm and having a predetermined number of

  9. Functional Programming in C# Classic Programming Techniques for Modern Projects

    CERN Document Server

    Sturm, Oliver

    2011-01-01

    Take advantage of the growing trend in functional programming. C# is the number-one language used by .NET developers and one of the most popular programming languages in the world. It has many built-in functional programming features, but most are complex and little understood. With the shift to functional programming increasing at a rapid pace, you need to know how to leverage your existing skills to take advantage of this trend. Functional Programming in C# leads you along a path that begins with the historic value of functional ideas. Inside, C# MVP and functional programming expert Oli

  10. Programming in biomolecular computation

    DEFF Research Database (Denmark)

    Hartmann, Lars Røeboe; Jones, Neil; Simonsen, Jakob Grue

    2011-01-01

    Our goal is to provide a top-down approach to biomolecular computation. In spite of widespread discussion about connections between biology and computation, one question seems notable by its absence: Where are the programs? We identify a number of common features in programming that seem...... conspicuously absent from the literature on biomolecular computing; to partially redress this absence, we introduce a model of computation that is evidently programmable, by programs reminiscent of low-level computer machine code; and at the same time biologically plausible: its functioning is defined...... by a single and relatively small set of chemical-like reaction rules. Further properties: the model is stored-program: programs are the same as data, so programs are not only executable, but are also compilable and interpretable. It is universal: all computable functions can be computed (in natural ways...

  11. MIDI Programming in Scheme

    DEFF Research Database (Denmark)

    Nørmark, Kurt

    2010-01-01

    makes it possible to carry out systematic modifications and transformations of MIDI contents with use of pure functional programming. Side by side with the XML-inspired MIDI language, the paper describes an Emacs-based, textual programming environment that supports the MIDI programming process....... The programming environment also supports a variety of interactive features - similar to MIDI sequencers - but restricted to a textual representation of the music. The main contributions of the work are considered to be (1) An accumulated MIDI function library, which can transform MIDI files in many non......-trivial ways; (2) A proposed working process alternating between creative mode and programmatic editing mode within a MIDI programming environment; and (3) A textual MIDI programming environment with embedded support of many interactive, MIDI-related functionalities....

  12. A unified approach to feature-centric analysis of object-oriented software

    DEFF Research Database (Denmark)

    Olszak, Andrzej; Jørgensen, Bo Nørregaard

    2010-01-01

    Feature-centric comprehension of software is a prerequisite to incorporating modifications requested by users during software evolution and maintenance. However, feature-centric understanding of large object-oriented programs is difficult to achieve due to size, complexity and implicit cha......-racter of mappings between features and source code. In this paper, we address these issues through our unified approach to feature-centric analysis of object-oriented software. Our approach supports discovery of feature-code traceability links and their analysis from three perspectives and at three levels...... of abstraction. We further improve scalability of analysis by partitioning features into canonical groups. To demonstrate feasibility our approach, we use our NetBeans-integrated tool Featureous for conducting a case study of feature-centric analysis of the JHotDraw project. Lastly, we discuss how Featureous...

  13. The Use of Molecular Modeling Programs in Medicinal Chemistry Instruction.

    Science.gov (United States)

    Harrold, Marc W.

    1992-01-01

    This paper describes and evaluates the use of a molecular modeling computer program (Alchemy II) in a pharmaceutical education program. Provided are the hardware requirements and basic program features as well as several examples of how this program and its features have been applied in the classroom. (GLR)

  14. Validity maintenance in semantic feature modeling

    NARCIS (Netherlands)

    Bidarra de Almeida, A.R.E.

    1999-01-01

    Feature modeling has the ability to associate functional and engineering information to shape information in a product model. Current feature modeling systems, however, are still rather tied to techniques of conventional geometric modeling systems, offering limited facilities for defining feature

  15. Semisupervised Feature Selection with Universum

    Directory of Open Access Journals (Sweden)

    Junyang Qiu

    2016-01-01

    Full Text Available The Universum data, defined as a set of unlabeled examples that do not belong to any class of interest, have been shown to encode some prior knowledge by representing meaningful information in the same domain as the problem at hand. Universum data have been proved effective in improving learning performance in many tasks, such as classification and clustering. Inspired by its favorable performance, we address a novel semisupervised feature selection problem in this paper, called semisupervised feature selection with Universum, that can simultaneously exploit the unlabeled data and the Universum data. The experiments on several UCI data sets are presented to show that the proposed algorithms can achieve superior performances over conventional unsupervised and supervised methods.

  16. Manipulating scattering features by metamaterials

    Directory of Open Access Journals (Sweden)

    Lu Cui

    2016-01-01

    Full Text Available We present a review on manipulations of electromagnetic scattering features by using metamaterials or metasurfaces. Several approaches in controlling the scattered fields of objects are presented, including invisibility cloaks and radar illusions based on transformation optics, carpet cloak using gradient metamaterials, dc cloaks, mantle cloaks based on scattering cancellation, “skin” cloaks using phase compensation, scattering controls with coding/programmable metasurfaces, and scattering reductions by multilayered structures. Finally, the future development of metamaterials on scattering manipulation is predicted.

  17. Integrated reporting and board features

    OpenAIRE

    Rares HURGHIS

    2017-01-01

    In the last two decades the concept of sustainability reporting gained more importance in the companies’ annual reports, a trend which is embedded also in integrated reporting. Issuing an integrated report became a necessity, because the report explains to the investors how the organization creates value over time. The governance structure, more exactly the board of directors, decides whether or not the company will issue an integrated report. Thus, are there certain features of the board tha...

  18. Cherubism: Clinicoradiographic Features and Treatment

    Directory of Open Access Journals (Sweden)

    Luiz Antonio Guimarães Cabral

    2010-04-01

    Full Text Available Objectives: Cherubism is a congenital childhood disease of autosomal dominant inheritance. This disease is characterized by painless bilateral enlargement of the jaws, in which bone is replaced with fibrous tissue. The condition has sui generis clinical, radiographic and histological features, of which the clinician should be aware for a better differential diagnosis in the presence of a fibro-osseous lesion affecting the bones of the maxillomandibular complex. The purpose of present paper was to review the literature and to report the most important aspects of cherubism in order to facilitate the study of this disease.Material and Methods: Literature was reviewed about cherubism, emphasizing the relevant clinicoradiographic features and treatment. Literature was selected through a search of PubMed and Scielo electronic databases. The keywords used for search were adolescent, cherubism, cherubism/physiopathology, cherubism/treatment, cherubism/radiography. A manual search of the reference lists of the identified articles and the authors’ article files and recent reviews was conducted to identify additional publications. Those studies that described new features about cherubism were included in this review.Results: In total 44 literature sources were obtained and reviewed. Studies that described new features about cherubism physiopathology, diagnostics and treatment were reviewed.Conclusions: Despite the exceptions, cherubism is a clinically well-characterized disease. In cases of a suspicion of cherubism, radiographic examination is essential since the clinical presentation, the location and distribution of the lesions may define the diagnosis. Histopathological examination is complementary. Nowadays, genetic tests should be used for final diagnosis of cherubism.

  19. Cherubism: Clinicoradiographic Features and Treatment

    Science.gov (United States)

    Almeida, Janete Dias; Cabral, Luiz Antonio Guimarães

    2010-01-01

    ABSTRACT Objectives Cherubism is a congenital childhood disease of autosomal dominant inheritance. This disease is characterized by painless bilateral enlargement of the jaws, in which bone is replaced with fibrous tissue. The condition has sui generis clinical, radiographic and histological features, of which the clinician should be aware for a better differential diagnosis in the presence of a fibro-osseous lesion affecting the bones of the maxillomandibular complex. The purpose of present paper was to review the literature and to report the most important aspects of cherubism in order to facilitate the study of this disease Material and Methods Literature was reviewed about cherubism, emphasizing the relevant clinicoradiographic features and treatment. Literature was selected through a search of PubMed and Scielo electronic databases. The keywords used for search were adolescent, cherubism, cherubism/physiopathology, cherubism/treatment, cherubism/radiography. A manual search of the reference lists of the identified articles and the authors' article files and recent reviews was conducted to identify additional publications. Those studies that described new features about cherubism were included in this review. Results In total 44 literature sources were obtained and reviewed. Studies that described new features about cherubism physiopathology, diagnostics and treatment were reviewed. Conclusions Despite the exceptions, cherubism is a clinically well-characterized disease. In cases of a suspicion of cherubism, radiographic examination is essential since the clinical presentation, the location and distribution of the lesions may define the diagnosis. Histopathological examination is complementary. Nowadays, genetic tests should be used for final diagnosis of cherubism. PMID:24421967

  20. Cherubism: Clinicoradiographic Features and Treatment

    OpenAIRE

    Luiz Antonio Guimarães Cabral; Janete Dias Almeida; Gabriela de Morais Gouvêa Lima

    2010-01-01

    ABSTRACT Objectives Cherubism is a congenital childhood disease of autosomal dominant inheritance. This disease is characterized by painless bilateral enlargement of the jaws, in which bone is replaced with fibrous tissue. The condition has sui generis clinical, radiographic and histological features, of which the clinician should be aware for a better differential diagnosis in the presence of a fibro-osseous lesion affecting the bones of the maxillomandibular complex. The purpose of present ...

  1. Combining macro and micro features for writer identification

    Science.gov (United States)

    Lee, Sangjik; Cha, Sung-Hyuk; Srihari, Sargur N.

    2001-12-01

    In our previous work of writer identification, a database of handwriting samples (written in English) of over one thousand individuals was created, and two types of computer-generated features of sample handwriting were extracted: macro and micro features. Using these features, writer identification experiments were performed: given that a document is written by one of n writers, the task is to determine the writer. With n = 2, we correctly determined the writer with a 99% accuracy using only 10-character micro features in the writing; with n = 1000, the accuracy is dropped to 80%. To obtain higher performance, we propose a combination of macro and micro level features. First, macro level features are used in a filtering model: the computer program is presented with multiple handwriting samples from a large number (1000) of writers, and the question posed is: Which of the samples are consistent with a test sample? As a result of using the filtering model, a reduced set of documents (100) is obtained and presented to the final identification model which uses the micro level features. We improved our writer identification system from 80% to 87.5% by the proposed filtering-combination technique when n = 1000.

  2. Feature-based tolerancing for intelligent inspection process definition

    Energy Technology Data Exchange (ETDEWEB)

    Brown, C.W.

    1993-07-01

    This paper describes a feature-based tolerancing capability that complements a geometric solid model with an explicit representation of conventional and geometric tolerances. This capability is focused on supporting an intelligent inspection process definition system. The feature-based tolerance model`s benefits include advancing complete product definition initiatives (e.g., STEP -- Standard for Exchange of Product model dam), suppling computer-integrated manufacturing applications (e.g., generative process planning and automated part programming) with product definition information, and assisting in the solution of measurement performance issues. A feature-based tolerance information model was developed based upon the notion of a feature`s toleranceable aspects and describes an object-oriented scheme for representing and relating tolerance features, tolerances, and datum reference frames. For easy incorporation, the tolerance feature entities are interconnected with STEP solid model entities. This schema will explicitly represent the tolerance specification for mechanical products, support advanced dimensional measurement applications, and assist in tolerance-related methods divergence issues.

  3. Melancholic features related to rimonabant.

    Science.gov (United States)

    de Mattos Viana, Bernardo; Prais, Hugo Alejandro Cano; Daker, Maurício Viotti

    2009-01-01

    Obesity is currently considered a global epidemic and its prevention and treatment is a major public health concern, demanding treatment which may combine a sociocultural approach, lifestyle modification, nutritional, pharmacological or surgical strategies. Rimonabant, an endocannabinoid antagonist, has been proposed as an agent for an average weight loss of 4 kg. However, the development of anxiety and depressive symptoms can be major side effects. A 27-year-old businessman, after using rimonabant (20 mg/day) for 1 month for weight loss, developed a major depressive episode with melancholic features, which remitted after the interruption of rimonabant. To our knowledge, a major depressive episode with melancholic or atypical features specifier has not been described since the initiation of rimonabant pharmacological trials. The Hospital Anxiety and Depression Scale, used in the rimonabant trials, assesses several key points of depressive patients. However, it neglects the somatic symptoms that correspond to the additional criterion for both of the mentioned features as well as suicidal ideation. The severity of an episode could also be underestimated depending on the assessment tool or on the clinical interview. There may be an underestimation of depressive melancholic and atypical side effects related to Rimonabant use, due to the lack of consistent assessment with the appropriate screening tools. Pharmacological strategies should be adjunctive for obesity treatment when there is a failure in the lifestyle and nutritional modification strategies. Moreover, deeper global sociocultural changes should be made in the treatment and control of the global obesity epidemic.

  4. Dissociative features of fibromyalgia syndrome.

    Science.gov (United States)

    Berkol, Tonguc D; Balcioglu, Yasin H; Kirlioglu, Simge S; Erensoy, Habib; Vural, Meltem

    2017-07-01

    To assess the relationships between the dissociative features of FMS and the pain, psychological status, and functional status. Twenty-seven women with fibromyalgia syndrome (FMS) and 24 controls from the Istanbul Physical Medicine and Rehabilitation Hospital (2013-2015) were included in this cross-sectional study. The Diagnostic and Statistical Manual of Mental Disorders Structured Clinical Interview for Axis I Disorders was used to evaluate the participants. A visual analogous scale (VAS), Fibromyalgia Impact Questionnaire (FIQ), Beck Depression Inventory (BDI), and Beck Anxiety Inventory (BAI) were used to assess the levels of pain, quality of sleep and functional and psychological statuses. The Dissociative Experiences Scale (DES) was used to evaluate the dissociative features. The BDI, BAI and DES scores were statistically significantly higher in the cases of FMS. There were remarkable associations between all but 2 of the DES and FIQ scores, while positive correlations were found between the DES and, VAS pain and sleep quality scores. The prevalences of current and lifelong dysthymia, and major depressive disorder; not otherwise specified, common anxiety and somatoform disorders were higher in the cases of FMS. Pain, physical function and emotional status appear to be associated with dissociative features in FMS. Further studies are required to define these relationships and improve treatment.

  5. Imaging features of aggressive angiomyxoma

    Energy Technology Data Exchange (ETDEWEB)

    Jeyadevan, N.N.; Sohaib, S.A.A.; Thomas, J.M.; Jeyarajah, A.; Shepherd, J.H.; Fisher, C

    2003-02-01

    AIM: To describe the imaging features of aggressive angiomyxoma in a rare benign mesenchymal tumour most frequently arising from the perineum in young female patients. MATERIALS AND METHODS: We reviewed the computed tomography (CT) and magnetic resonance (MR) imaging features of patients with aggressive angiomyxoma who were referred to our hospital. The imaging features were correlated with clinical information and pathology in all patients. RESULTS: Four CT and five MR studies were available for five patients (all women, mean age 39, range 24-55). Three patients had recurrent tumour at follow-up. CT and MR imaging demonstrated a well-defined mass-displacing adjacent structures. The tumour was of low attenuation relative to muscle on CT. On MR, the tumour was isointense relative to muscle on T1-weighted image, hyperintense on T2-weighted image and enhanced avidly after gadolinium contrast with a characteristic 'swirled' internal pattern. MR imaging demonstrates the extent of the tumour and its relation to the pelvic floor. Recurrent tumour has a similar appearance to the primary lesion. CONCLUSION: The MR appearances of aggressive angiomyxomas are characteristic, and the diagnosis should be considered in any young woman presenting with a well-defined mass arising from the perineum. Jeyadevan, N. N. etal. (2003). Clinical Radiology58, 157--162.

  6. Benign dermoscopic features in melanoma.

    Science.gov (United States)

    Di Stefani, A; Massone, C; Soyer, H P; Zalaudek, I; Argenziano, G; Arzberger, E; Lozzi, G P; Chimenti, S; Hofmann-Wellenhof, R

    2014-06-01

    Various dermoscopic features are usually associated with benign melanocytic lesions. Our objective was to determine frequency and extension of benign dermoscopic features (BDF) in melanoma. Retrospective review of dermoscopic images of a consecutive series of 516 histopathologically proven melanomas collected in 6 years in Graz. Correlation of BDF with mean Breslow thickness, with presence/absence of associated benign nevus component and with the pre-operative clinico-dermoscopic diagnosis, as reported on the original histopathologic reports. In addition to melanoma specific criteria, 42% of melanomas showed BDF. In 12.3% cases, the benign features occupied more than the half of the lesion. The BDF typical pigment network, homogeneous pattern and regular globules/cobblestone pattern had the highest frequency. BDF were associated with relatively thinner melanomas (mean Breslow thickness of 0.51 mm). The presence of BDF was observed in 67.1% of histopathologically documented nevus-associated melanoma and in 35.7% of melanoma de novo. A pre-operative clinico-dermoscopic diagnosis of melanoma was achieved in only 54.1% of cases displaying BDF. A significant proportion of melanomas may exhibit BDF. Clinicians should be aware of the presence of BDF in melanoma as possible diagnostic pitfall. © 2013 European Academy of Dermatology and Venereology.

  7. Temporal Feature Integration for Music Organisation

    OpenAIRE

    Meng, Anders; Larsen, Jan; Hansen, Lars Kai

    2006-01-01

    This Ph.D. thesis focuses on temporal feature integration for music organisation. Temporal feature integration is the process of combining all the feature vectors of a given time-frame into a single new feature vector in order to capture relevant information in the frame. Several existing methods for handling sequences of features are formulated in the temporal feature integration framework. Two datasets for music genre classification have been considered as valid test-beds for music organisa...

  8. Programming C# Building NET Applications with C#

    CERN Document Server

    Liberty, Jesse

    2009-01-01

    Programming C#, the top-selling book on Microsoft's high-performance C# programming language, is now in its fourth edition. Aimed at experienced programmers and web developers, this comprehensive guide focuses on the features and programming patterns that are unique to C#, and fundamental to the programming of web services and web applications on Microsoft's .NET platform.

  9. Structural Features of Caspase-Activating Complexes

    Directory of Open Access Journals (Sweden)

    Hyun Ho Park

    2012-04-01

    Full Text Available Apoptosis, also called programmed cell death, is an orderly cellular suicide program that is critical for the development, immune regulation and homeostasis of a multi-cellular organism. Failure to control this process can lead to serious human diseases, including many types of cancer, neurodegenerative diseases, and autoimmununity. The process of apoptosis is mediated by the sequential activation of caspases, which are cysteine proteases. Initiator caspases, such as caspase-2, -8, -9, and -10, are activated by formation of caspase-activating complexes, which function as a platform to recruit caspases, providing proximity for self-activation. Well-known initiator caspase-activating complexes include (1 DISC (Death Inducing Signaling Complex, which activates caspases-8 and 10; (2 Apoptosome, which activates caspase-9; and (3 PIDDosome, which activates caspase-2. Because of the fundamental biological importance of capases, many structural and biochemical studies to understand the molecular basis of assembly mechanism of caspase-activating complexes have been performed. In this review, we summarize previous studies that have examined the structural and biochemical features of caspase-activating complexes. By analyzing the structural basis for the assembly mechanism of the caspase-activating complex, we hope to provide a comprehensive understanding of caspase activation by these important oligomeric complexes.

  10. Identification of Chemical Features Linked to Thyroperoxidase ...

    Science.gov (United States)

    Disruption of maternal serum thyroid hormone (TH) adversely affects fetal neurodevelopment. Therefore, assay development within the US EPA ToxCast program is ongoing to enable screening for chemicals that may disrupt TH, in support of the Endocrine Disruption Screening Program (EDSP21). The AUR-TPO assay was recently developed to screen >1,000 ToxCast chemicals for potential thyroperoxidase (TPO) inhibition activity. TPO is critical for TH synthesis and is a known target of thyroid-disrupting chemicals. The bioactivity results from the AUR-TPO assay were used to identify chemical substructures associated with in vitro TPO inhibition. Substructure profiles were generated for each chemical in the ToxCast test set using the publicly-available ToxPrint 2.0 chemotypes. Chemotypes enriched among the putative TPO inhibitors were identified using a cumulative hypergeometric probability (p chemicals active in the AUR-TPO assay: aromatic alcohols, aromatic amines, thiocarbonyls and phosphothioates. Chemico-structural analysis of AUR-TPO screening results enabled the identification of chemical features that likely drive TPO inhibition in the AUR-TPO assay. This highlights the potential to identify thyroid-disrupting chemicals in silico using structural alerts identified by

  11. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Safety Advanced Skills Course for Rural Surgeons Support the Work of the Nora Institute Featured Articles Nora Institute Mission The ... of Surgeons Professional Association State Legislative Action Center Leadership & Advocacy ... Quality Payment Program AMA House of Delegates ACS in the AMA House of Delegates ACS in the AMA ...

  12. Menu-Driven Solver Of Linear-Programming Problems

    Science.gov (United States)

    Viterna, L. A.; Ferencz, D.

    1992-01-01

    Program assists inexperienced user in formulating linear-programming problems. A Linear Program Solver (ALPS) computer program is full-featured LP analysis program. Solves plain linear-programming problems as well as more-complicated mixed-integer and pure-integer programs. Also contains efficient technique for solution of purely binary linear-programming problems. Written entirely in IBM's APL2/PC software, Version 1.01. Packed program contains licensed material, property of IBM (copyright 1988, all rights reserved).

  13. Poly(2,5-dimercapto-1,3,4-thiadiazole) as a Cathode for Rechargeable Lithium Batteries with Dramatically Improved Performance

    KAUST Repository

    Gao, Jie

    2012-05-29

    Organosulfur compounds with multiple thiol groups are promising for high gravimetric energy density electrochemical energy storage. We have synthesized a poly(2,5-dimercapto-1,3,4-thiadiazole) (PDMcT)/poly(3,4-ethylenedioxythiophene) (PEDOT) composite cathode for lithium-ion batteries with a new method and investigated its electrochemical behavior by charge/discharge cycles and cyclic voltammetry (CV) in an ether-based electrolyte. Based on a comparison of the electrochemical performance with a carbonate-based electrolyte, we found a much higher discharge capacity, but also a very attractive cycling performance of PDMcT by using a tetra(ethylene glycol) dimethyl ether (TEGDME)-based electrolyte. The first discharge capacity of the as-synthesized PDMcT/PEDOT composite approached 210 mAh g -1 in the TEGDME-based electrolyte. CV results clearly show that the redox reactions of PDMcT are highly reversible in this TEGDME-based electrolyte. The reversible capacity remained around 120 mAh g -1 after 20 charge/discharge cycles. With improved cycling performance and very low cost, PDMcT could become a very promising cathode material when combined with a TEGDME-based electrolyte. The poor capacity in the carbonate-based electrolyte is a consequence of the irreversible reaction of the DMcT monomer and dimer with the solvent, emphasizing the importance of electrolyte chemistry when studying molecular-based battery materials. The nature of the electrolyte has a dramatic effect on the performance of poly(2,5-dimercapto-1,3,4-thiadiazole) (PDMcT) as a cathode material in lithium-ion batteries. Whereas the use of an ethylene/diethyl carbonate (EC/DEC)-based electrolyte resulted in very poor performance, the use of a tetra(ethylene glycol) dimethyl ether (TEGDME)-based electrolyte dramatically improved the performance in terms of both the discharge capacity and capacity retention (see scheme). Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  14. Declarative programming in PROLOG

    Directory of Open Access Journals (Sweden)

    Felician ALECU

    2014-03-01

    Full Text Available The declarative programming by declarative languages is clearly the best option a programmer can have for a completely readable, flexible and extensible code. Today, the economics of programming is clearly focused on the declarative paradigm while most imperative languages are trying to become cost effective by using new added declarative features for productivity and ease of use, like the Java 8. This paper tries to demonstrate a declarative language like PROLOG is perfectly suitable to be used to solve even common programming issue, like deciding an element is part of an array or not.

  15. Programming Scala Scalability = Functional Programming + Objects

    CERN Document Server

    Wampler, Dean

    2009-01-01

    Learn how to be more productive with Scala, a new multi-paradigm language for the Java Virtual Machine (JVM) that integrates features of both object-oriented and functional programming. With this book, you'll discover why Scala is ideal for highly scalable, component-based applications that support concurrency and distribution. Programming Scala clearly explains the advantages of Scala as a JVM language. You'll learn how to leverage the wealth of Java class libraries to meet the practical needs of enterprise and Internet projects more easily. Packed with code examples, this book provides us

  16. The State of Enrollment Management in Journalism and Mass Communication Programs.

    Science.gov (United States)

    Rawlins, Brad L.; Soenksen, Roger; Jensen, Matt

    Some programs in journalism and mass communication have been forced to incorporate limited enrollment strategies, as undergraduate interest in these programs continues to grow. After 4 years of moderate growth, undergraduate enrollments in journalism and mass communication programs increased dramatically in the year 2000. Some of the limited…

  17. A forest-based feature screening approach for large-scale genome data with complex structures.

    Science.gov (United States)

    Wang, Gang; Fu, Guifang; Corcoran, Christopher

    2015-12-23

    Genome-wide association studies (GWAS) interrogate large-scale whole genome to characterize the complex genetic architecture for biomedical traits. When the number of SNPs dramatically increases to half million but the sample size is still limited to thousands, the traditional p-value based statistical approaches suffer from unprecedented limitations. Feature screening has proved to be an effective and powerful approach to handle ultrahigh dimensional data statistically, yet it has not received much attention in GWAS. Feature screening reduces the feature space from millions to hundreds by removing non-informative noise. However, the univariate measures used to rank features are mainly based on individual effect without considering the mutual interactions with other features. In this article, we explore the performance of a random forest (RF) based feature screening procedure to emphasize the SNPs that have complex effects for a continuous phenotype. Both simulation and real data analysis are conducted to examine the power of the forest-based feature screening. We compare it with five other popular feature screening approaches via simulation and conclude that RF can serve as a decent feature screening tool to accommodate complex genetic effects such as nonlinear, interactive, correlative, and joint effects. Unlike the traditional p-value based Manhattan plot, we use the Permutation Variable Importance Measure (PVIM) to display the relative significance and believe that it will provide as much useful information as the traditional plot. Most complex traits are found to be regulated by epistatic and polygenic variants. The forest-based feature screening is proven to be an efficient, easily implemented, and accurate approach to cope whole genome data with complex structures. Our explorations should add to a growing body of enlargement of feature screening better serving the demands of contemporary genome data.

  18. Comparative Study on Feature Selection and Fusion Schemes for Emotion Recognition from Speech

    Directory of Open Access Journals (Sweden)

    Santiago Planet

    2012-09-01

    Full Text Available The automatic analysis of speech to detect affective states may improve the way users interact with electronic devices. However, the analysis only at the acoustic level could be not enough to determine the emotion of a user in a realistic scenario. In this paper we analyzed the spontaneous speech recordings of the FAU Aibo Corpus at the acoustic and linguistic levels to extract two sets of features. The acoustic set was reduced by a greedy procedure selecting the most relevant features to optimize the learning stage. We compared two versions of this greedy selection algorithm by performing the search of the relevant features forwards and backwards. We experimented with three classification approaches: Naïve-Bayes, a support vector machine and a logistic model tree, and two fusion schemes: decision-level fusion, merging the hard-decisions of the acoustic and linguistic classifiers by means of a decision tree; and feature-level fusion, concatenating both sets of features before the learning stage. Despite the low performance achieved by the linguistic data, a dramatic improvement was achieved after its combination with the acoustic information, improving the results achieved by this second modality on its own. The results achieved by the classifiers using the parameters merged at feature level outperformed the classification results of the decision-level fusion scheme, despite the simplicity of the scheme. Moreover, the extremely reduced set of acoustic features obtained by the greedy forward search selection algorithm improved the results provided by the full set.

  19. Java 7 New Features Cookbook

    CERN Document Server

    Reese, Richard M

    2012-01-01

    Each recipe comprises step-by-step instructions followed by an analysis of what was done in each task and other useful information. The book is designed so that you can read it chapter by chapter, or look at the list of recipes and refer to them in no particular order. Each example comes with its expected output to make your learning even easier. This book is designed to bring those who are familiar with Java up-to-speed on the new features found in Java 7.

  20. Gestão do trabalho docente: o "dramático" uso de si Managing the work of teaching: the "dramatic" use of self

    Directory of Open Access Journals (Sweden)

    Eliana Perez Gonçalves de Moura

    2009-01-01

    Full Text Available Aborda os processos coletivos, por meio dos quais os professores produzem-se sujeitos do trabalho, engendrados numa dimensão da experiência laboral que escapa à lógica da organização do trabalho e às práticas de gerenciamento nas escolas. Problematiza os modelos de formação em serviço, concebidos como estratégias de controle e padronização da prática docente. Propõe a gestão do trabalho docente como uma ação inerente à experiência, que supõe escolhas entre uma hierarquização de atos, de objetivos e de valores, assim como, uma tensão "dramática" do uso de si "por si" e "pelos outros".This study discusses the collective processes adopted by teachers to produce themselves as subjects of work and engendered at a dimension of work experience that escapes the logic of work organization and school management practices. In-service training models are discussed in that they are conceived as strategies of control and standardization of teaching practices. Teaching should be managed as an action inherent to experience, which depends on choices made from a series of hierarchically ranked acts, objective and values, as well as on the dramatic tension between the use of self "for oneself" and "for others".

  1. Dramatic Enhancement in Photoresponse of β-In2S3 through Suppression of Dark Conductivity by Synthetic Control of Defect-Induced Carrier Compensation.

    Science.gov (United States)

    Chaudhari, Nilima; Mandal, Lily; Game, Onkar; Warule, Sambhaji; Phase, Deodatta; Jadkar, Sandesh; Ogale, Satishchandra

    2015-08-19

    We report on the synthesis of dense and faceted indium sulfide (β-In2S3) nano-octahedron films on fluorine-doped tin oxide-coated glass by the hydrothermal method and their photoresponse properties in a flip chip device configuration. We have examined the temporal evolution of the phase constitution, morphology, and optoelectronic properties for films obtained after growth interruption at specific intervals. It is noted that, initially, an In(OH)3 film forms, which is gradually transformed to the β-In2S3 phase over time. In the case of the film wherein most, but not all, of In(OH)3 is consumed, an exceptionally large photoresponse (light to dark current ratio) of ∼10(4) and response time(s) (rise/fall) of ∼88/280 ms are realized. This superior performance is attributed to nearly complete carrier compensation achievable in the system under high pressure growth leading to dramatic reduction of dark conductivity. It is argued that the temporally growth-controlled equilibrium between quasi-In interstitials and cation vacancies dictates the optoelectronic properties.

  2. Transgenic upregulation of the condensed tannin pathway in poplar leads to a dramatic shift in leaf palatability for two tree-feeding Lepidoptera.

    Science.gov (United States)

    Boeckler, G Andreas; Towns, Megan; Unsicker, Sybille B; Mellway, Robin D; Yip, Lynn; Hilke, Ines; Gershenzon, Jonathan; Constabel, C Peter

    2014-02-01

    Transgenic hybrid aspen (Populus tremula x tremuloides) overexpressing the MYB134 tannin regulatory gene show dramatically enhanced condensed tannin (proanthocyanidin) levels, as well as shifts in other phenolic metabolites. A series of insect bioassays with forest tent caterpillars (Malacosoma disstria) and gypsy moth (Lymantria dispar) caterpillars was carried out to determine how this metabolic shift affects food preference and performance of generalist tree-feeding lepidopterans. Both species showed a distinct preference for the high-tannin MYB134 overexpressor plants, and L. dispar performance was enhanced relative to controls. L. dispar reached greater pupal weight and showed reduced time to pupation when reared on the MYB134 overexpressing poplar. These results were unexpected since enhanced condensed tannin levels were predicted to act as feeding deterrents. However, the data may be explained by the observed decrease in the salicinoids (phenolic glycosides) salicortin and tremulacin that accompanied the upregulation of the condensed tannins in the transgenics. We conclude that for these two lepidopteran species, condensed tannin levels are unlikely to be a major determinant of caterpillar food preference or performance. However, our experiments show that overexpression of a single regulatory gene in transgenic aspen can have a significant impact on herbivorous insects.

  3. DISCOVERY OF DRAMATIC OPTICAL VARIABILITY IN SDSS J1100+4421: A PECULIAR RADIO-LOUD NARROW-LINE SEYFERT 1 GALAXY?

    Energy Technology Data Exchange (ETDEWEB)

    Tanaka, Masaomi [National Astronomical Observatory of Japan, Mitaka, Tokyo 181-8588 (Japan); Morokuma, Tomoki; Doi, Mamoru; Kikuchi, Yuki [Institute of Astronomy, School of Science, University of Tokyo, Mitaka, Tokyo 181-0015 (Japan); Itoh, Ryosuke [Department of Physical Sciences, Hiroshima University, Higashi-Hiroshima, Hiroshima 739-8526 (Japan); Akitaya, Hiroshi; Tanaka, Yasuyuki T.; Kawabata, Koji S. [Hiroshima Astrophysical Science Center, Hiroshima University, Higashi-Hiroshima, Hiroshima 739-8526 (Japan); Tominaga, Nozomu [Department of Physics, Faculty of Science and Engineering, Konan University, Kobe, Hyogo 658-8501 (Japan); Saito, Yoshihiko; Kawai, Nobuyuki [Department of Physics, Tokyo Institute of Technology, Meguro-ku, Tokyo 152-8551 (Japan); Stawarz, Łukasz [Institute of Space and Astronautical Science, JAXA, Sagamihara, Kanagawa 252-5210 (Japan); Gandhi, Poshak [Department of Physics, Durham University, Durham DH1-3LE (United Kingdom); Ali, Gamal; Essam, Ahmad; Hamed, Gamal [National Research Institute of Astronomy and Geophysics, Helwan, Cairo (Egypt); Aoki, Tsutomu [Kiso Observatory, Institute of Astronomy, School of Science, The University of Tokyo, Kiso, Nagano 397-0101 (Japan); Contreras, Carlos; Hsiao, Eric Y. [Carnegie Observatories, Las Campanas Observatory, Colina El Pino, Casilla 601 (Chile); Iwata, Ikuru, E-mail: masaomi.tanaka@nao.ac.jp [Subaru Telescope, National Astronomical Observatory of Japan, Hilo, HI 96720 (United States); and others

    2014-10-01

    We present our discovery of dramatic variability in SDSS J1100+4421 by the high-cadence transient survey Kiso Supernova Survey. The source brightened in the optical by at least a factor of three within about half a day. Spectroscopic observations suggest that this object is likely a narrow-line Seyfert 1 galaxy (NLS1) at z = 0.840, however, with unusually strong narrow emission lines. The estimated black hole mass of ∼10{sup 7} M {sub ☉} implies bolometric nuclear luminosity close to the Eddington limit. SDSS J1100+4421 is also extremely radio-loud, with a radio loudness parameter of R ≅ 4 × 10{sup 2}-3 × 10{sup 3}, which implies the presence of relativistic jets. Rapid and large-amplitude optical variability of the target, reminiscent of that found in a few radio- and γ-ray-loud NLS1s, is therefore produced most likely in a blazar-like core. The 1.4 GHz radio image of the source shows an extended structure with a linear size of about 100 kpc. If SDSS J1100+4421 is a genuine NLS1, as suggested here, this radio structure would then be the largest ever discovered in this type of active galaxies.

  4. It IS worth the effort: Patient knowledge of reproductive aspects of inflammatory bowel disease improves dramatically after a single group education session.

    Science.gov (United States)

    Mountifield, Réme; Andrews, Jane M; Bampton, Peter

    2014-08-01

    Individuals with Inflammatory Bowel Disease (IBD) have poor knowledge regarding the implications of disease for fertility and pregnancy. Previous studies suggest that this poor knowledge adversely influences reproductive decision making. To examine the effect of a single group education session on IBD-specific reproductive knowledge in subjects with IBD. People with IBD attending an educational event were invited to complete the CCPKnow questionnaire, testing reproductive knowledge in IBD, before and after an evidenced based presentation on this topic delivered by a Gastroenterologist. Of 248 attendees, 155 participated; 69% female, mean age 40.3years. CCPKnow scores (maximum 17) were low at baseline and increased significantly post education (mean 5.4 pre vs. 14.5 post education; ppregnancy: 33.5% of subjects indicated at baseline that women should avoid all drugs in pregnancy compared with only 1.2% post education (p<0.0001). A single group-delivered education event focussed on reproductive issues in IBD can dramatically improve patient knowledge. This has the potential to change reproductive behaviour and may reduce voluntary childlessness resulting from misperceptions amongst individuals with IBD. Crown Copyright © 2013. Published by Elsevier B.V. All rights reserved.

  5. Lonicera Implexa leaves bearing naturally laid eggs of the specialist herbivore Euphydryas Aurinia have dramatically greater concentrations of iridoid glycosides than other leaves.

    Science.gov (United States)

    Peñuelas, Josep; Sardans, Jordi; Stefanescu, Constantí; Parella, Teodor; Filella, Iolanda

    2006-09-01

    We tested in the field the hypothesis that the specialist butterfly Euphydryas aurinia (Lepidoptera: Nymphalidae, Melitaeinae) lays eggs on leaves of Lonicera implexa (Caprifoliaceae) plants with greater iridoid concentrations. We conducted our investigations in a Mediterranean site by analyzing leaves with and without naturally laid egg clusters. There were no significant differences in iridoid glycoside concentrations between leaves from plants that did not receive eggs and the unused leaves from plants receiving eggs, a fact that would seem to indicate that E. aurinia butterflies do not choose plants for oviposition by their iridoid content. However, the leaves of L. implexa that bore egg clusters had dramatically greater (over 15-fold) concentrations of iridoid glycosides than the directly opposite leaves on the same plant. These huge foliar concentrations of iridoids (15% leaf dry weight) may provide specialist herbivores with compounds that they either sequester for their own defense or use as a means of avoiding competition for food from generalist herbivores. Nevertheless, it may still be possible that these high concentrations are detrimental to the herbivore, even if the herbivore is a specialist feeder on the plant.

  6. Female Listeners' Autonomic Responses to Dramatic Shifts Between Loud and Soft Music/Sound Passages: A Study of Heavy Metal Songs.

    Science.gov (United States)

    Cheng, Tzu-Han; Tsai, Chen-Gia

    2016-01-01

    Although music and the emotion it conveys unfold over time, little is known about how listeners respond to shifts in musical emotions. A special technique in heavy metal music utilizes dramatic shifts between loud and soft passages. Loud passages are penetrated by distorted sounds conveying aggression, whereas soft passages are often characterized by a clean, calm singing voice and light accompaniment. The present study used heavy metal songs and soft sea sounds to examine how female listeners' respiration rates and heart rates responded to the arousal changes associated with auditory stimuli. The high-frequency power of heart rate variability (HF-HRV) was used to assess cardiac parasympathetic activity. The results showed that the soft passages of heavy metal songs and soft sea sounds expressed lower arousal and induced significantly higher HF-HRVs than the loud passages of heavy metal songs. Listeners' respiration rate was determined by the arousal level of the present music passage, whereas the heart rate was dependent on both the present and preceding passages. Compared with soft sea sounds, the loud music passage led to greater deceleration of the heart rate at the beginning of the following soft music passage. The sea sounds delayed the heart rate acceleration evoked by the following loud music passage. The data provide evidence that sound-induced parasympathetic activity affects listeners' heart rate in response to the following music passage. These findings have potential implications for future research on the temporal dynamics of musical emotions.

  7. ppGpp Binding to a Site at the RNAP-DksA Interface Accounts for Its Dramatic Effects on Transcription Initiation during the Stringent Response.

    Science.gov (United States)

    Ross, Wilma; Sanchez-Vazquez, Patricia; Chen, Albert Y; Lee, Jeong-Hyun; Burgos, Hector L; Gourse, Richard L

    2016-06-16

    Throughout the bacterial domain, the alarmone ppGpp dramatically reprograms transcription following nutrient limitation. This "stringent response" is critical for survival and antibiotic tolerance and is a model for transcriptional regulation by small ligands. We report that ppGpp binds to two distinct sites 60 Å apart on E. coli RNA polymerase (RNAP), one characterized previously (site 1) and a second identified here at an interface of RNAP and the transcription factor DksA (site 2). The location and unusual tripartite nature of site 2 account for the DksA-ppGpp synergism and suggest mechanisms for ppGpp enhancement of DksA's effects on RNAP. Site 2 binding results in the majority of ppGpp's effects on transcription initiation in vitro and in vivo, and strains lacking site 2 are severely impaired for growth following nutritional shifts. Filling of the two sites at different ppGpp concentrations would expand the dynamic range of cellular responses to changes in ppGpp levels. Copyright © 2016 Elsevier Inc. All rights reserved.

  8. Dramatic changes in a phytoplankton community in response to local and global pressures: a 24-year survey of the river Loire (France).

    Science.gov (United States)

    Larroudé, S; Massei, N; Reyes-Marchant, P; Delattre, C; Humbert, J F

    2013-05-01

    The impact of climate change and of other anthropogenic pressures on the structure and composition of phytoplankton communities of large European rivers remains poorly documented. Here we report the findings of a study of the changes in the phytoplankton community of the middle segment of the river Loire over the past 24 years. An attempt is made to distinguish between the impact of changes acting at the local scale and that of those acting more globally. A dramatic reduction in phytoplankton abundance was observed, particularly in the mid -1990s; this was concomitant with an increase in the relative proportion of cyanobacteria. At the same time, the phytoplankton community displayed increasing richness and diversity, and little change in its size structure. All these changes seem to be related to local changes, in particular to the reduction in phosphorus concentrations, as well as to changes in climate, throughout modifications in the river discharge and water temperature. Interestingly, herbicide contamination also appeared to be of particular importance in explaining the unexpected increase in the proportion of cyanobacteria in the phytoplankton community after the 1990s. These findings suggest that combinations of numerous anthropogenic pressures acting at different spatial and temporal scales have led to a mix of predictable and unpredictable changes occurring in the phytoplankton community of the river Loire, with probable consequences for the trophic networks in this river. © 2013 Blackwell Publishing Ltd.

  9. Traces of the Tragic Anti-Heroe in the Enigmatic Wife of Job? The Biblical Re-use of a Classical Dramatic Form

    Directory of Open Access Journals (Sweden)

    Giancarlo Toloni

    2017-07-01

    Full Text Available There are many analogies between the great protagonists of the Hebrew Bible and the Greek heroes of the archaic epic poetry, and the heroines of the classical theater. In particular, the figure of the wife of a right man – victimized and misunderstood precisely because of his unconditional faithfulness – is very close to that of the anti-hero of Sophocles’s theater, which strongly objects to the hero choice in name of the mentality of the common man; in both cases, the result is just the opposite of expectations, since it confirms the choice of the righteous/hero, helping to increase even more his isolation. On this literary form, the character of his wife might therefore have been placed in the story of Job; in fact, she was absent from the ancient legend that is the basis of the prologue and the epilogue, of the biblical book. The Old Greek (OG attests clearly that by its addition (v. 9a-e, by means of which, a little later, the intervention of Job’s wife was defined more favorably, and making her a kind of anti-heroine, on the dramatic scheme of the antagonism of Ismene and Chrysothemis against their respective hero, in the tragic theater of Sophocles. The Testament of Job appreciated this choice, and deepened the role of woman, by reworking even more benevolently her image appearing in the OG addition.

  10. Female listeners’ autonomic responses to dramatic shifts between loud and soft music/sound passages: a study of heavy metal songs

    Directory of Open Access Journals (Sweden)

    Tzu-Han eCheng

    2016-02-01

    Full Text Available Although music and the emotion it conveys unfold over time, little is known about how listeners respond to shifts in musical emotions. A special technique in heavy metal music utilizes dramatic shifts between loud and soft passages. Loud passages are penetrated by distorted sounds conveying aggression, whereas soft passages are often characterized by a clean, calm singing voice and light accompaniment. The present study used heavy metal songs and soft sea sounds to examine how female listeners’ respiration rates and heart rates responded to the arousal changes associated with auditory stimuli. The high-frequency power of heart rate variability (HF-HRV was used to assess cardiac parasympathetic activity. The results showed that the soft passages of heavy metal songs and soft sea sounds expressed lower arousal and induced significantly higher HF-HRVs than the loud passages of heavy metal songs. Listeners’ respiration rate was determined by the arousal level of the present music passage, whereas the heart rate was dependent on both the present and preceding passages. Compared with soft sea sounds, the loud music passage led to greater deceleration of the heart rate at the beginning of the following soft music passage. The sea sounds delayed the heart rate acceleration evoked by the following loud music passage. The data provide evidence that sound-induced parasympathetic activity affects listener’s heart rate in response to the following music passage. These findings have potential implications for future research of the temporal dynamics of musical emotions.

  11. Dramatic decrease in prevalence of soil-transmitted helminths and new insights into intestinal protozoa in children living in the Chaco region, Bolivia.

    Science.gov (United States)

    Macchioni, Fabio; Segundo, Higinio; Gabrielli, Simona; Totino, Valentina; Gonzales, Patricia Rojas; Salazar, Esteban; Bozo, Ricardo; Bartoloni, Alessandro; Cancrini, Gabriella

    2015-04-01

    We assessed the prevalence of intestinal parasites among 268 2-12-year-old children living in rural areas, small villages, and semi-urban areas of the Chaco region, south-eastern Bolivia. The overall parasitism was 69%. Only protozoa, helminths, or co-infections were observed in 89.2%, 5.9%, or 4.9% of the positive children, respectively. A significant progressive increase in overall parasite prevalence was found when passing from rural areas to small villages and semi-urban areas. The most commonly found species were Entamoeba coli (38.4%), Giardia intestinalis (37.7%), and Blastocystis spp. (16%). Hymenolepis nana was the most prevalent helminth (5.6%), followed by Ascaris lumbricoides and hookworms (1.5% and 0.4%) evidenced only in rural areas and in villages. Molecular diagnostics identified Blastocystis subtypes 9 and 2, and 5 infections by Entamoeba histolytica and 4 by Entamoeba dispar. The dramatic decrease in prevalence of soil-transmitted helminths with respect to that observed about 20 years ago (> 40%) evidences the success of the preventive chemotherapy intervention implemented in 1986. Health education and improved sanitation should be intensified to control protozoan infections. © The American Society of Tropical Medicine and Hygiene.

  12. Spectral analyses of asteroids' linear features

    Science.gov (United States)

    Longobardo, A.; Palomba, E.; Scully, J. E. C.; De Sanctis, M. C.; Capaccioni, F.; Tosi, F.; Zinzi, A.; Galiano, A.; Ammannito, E.; Filacchione, G.; Ciarniello, M.; Raponi, A.; Zambon, F.; Capria, M. T.; Erard, S.; Bockelee-Morvan, D.; Leyrat, C.; Dirri, F.; Nardi, L.; Raymond, C. A.

    2017-09-01

    Linear features are commonly found on small bodies and can have a geomorphic or tectonic origin. Generally, these features are studied by means of morphological analyses. Here we propose a spectroscopic analyses of linear features of different asteroids visited by space missions, in order to search for correspondence between spectral properties and origin of linear features.

  13. Some Questions about Feature Re-Assembly

    Science.gov (United States)

    White, Lydia

    2009-01-01

    In this commentary, differences between feature re-assembly and feature selection are discussed. Lardiere's proposals are compared to existing approaches to grammatical features in second language (L2) acquisition. Questions are raised about the predictive power of the feature re-assembly approach. (Contains 1 footnote.)

  14. Integrated reporting and board features

    Directory of Open Access Journals (Sweden)

    Rares HURGHIS

    2017-02-01

    Full Text Available In the last two decades the concept of sustainability reporting gained more importance in the companies’ annual reports, a trend which is embedded also in integrated reporting. Issuing an integrated report became a necessity, because the report explains to the investors how the organization creates value over time. The governance structure, more exactly the board of directors, decides whether or not the company will issue an integrated report. Thus, are there certain features of the board that might influence the issue of an integrated report? Do the companies which issue an integrated report have certain features of the governance structure? Looking for an answer to these questions, we seek for any possible correlations between a disclosure index and the corporate governance structure characteristics, on a sample from the companies participating at the International Integrated Reporting Council Examples Database. The results highlight that only the size of the board influences the extent to which the issued integrated report is in accordance with the International Framework.

  15. Mixed features in bipolar disorder.

    Science.gov (United States)

    Solé, Eva; Garriga, Marina; Valentí, Marc; Vieta, Eduard

    2017-04-01

    Mixed affective states, defined as the coexistence of depressive and manic symptoms, are complex presentations of manic-depressive illness that represent a challenge for clinicians at the levels of diagnosis, classification, and pharmacological treatment. The evidence shows that patients with bipolar disorder who have manic/hypomanic or depressive episodes with mixed features tend to have a more severe form of bipolar disorder along with a worse course of illness and higher rates of comorbid conditions than those with non-mixed presentations. In the updated Diagnostic and Statistical Manual of Mental Disorders (5th ed.; DSM-5), the definition of "mixed episode" has been removed, and subthreshold nonoverlapping symptoms of the opposite pole are captured using a "with mixed features" specifier applied to manic, hypomanic, and major depressive episodes. However, the list of symptoms proposed in the DSM-5 specifier has been widely criticized, because it includes typical manic symptoms (such as elevated mood and grandiosity) that are rare among patients with mixed depression, while excluding symptoms (such as irritability, psychomotor agitation, and distractibility) that are frequently reported in these patients. With the new classification, mixed depressive episodes are three times more common in bipolar II compared with unipolar depression, which partly contributes to the increased risk of suicide observed in bipolar depression compared to unipolar depression. Therefore, a specific diagnostic category would imply an increased diagnostic sensitivity, would help to foster early identification of symptoms and ensure specific treatment, as well as play a role in suicide prevention in this population.

  16. MR features of ectopic pregnancy

    Energy Technology Data Exchange (ETDEWEB)

    Tamai, Ken; Togashi, Kaori [Kyoto University, Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto (Japan); Koyama, Takashi [Kyoto University Hospital, Department of Radiology, Kyoto (Japan)

    2007-12-15

    Ectopic pregnancy (EP), in which a fertilized ovum implants outside the uterine cavity, is the leading cause of pregnancy-related death in the first trimester. EP is usually suspected by a positive pregnancy test and an empty uterus on transvaginal sonography (TVS). Although TVS is the initial modality of choice, it may occasionally fail to demonstrate the implantation site. When TVS findings are indeterminate, magnetic resonance imaging (MRI) may provide better delineation of the focus of EP owing to its excellent tissue contrast. The key MRI features of EP include gestational sac (GS)-like structures that typically appear as a cystic sac-like structure, frequently associated with surrounding acute hematoma of distinct low intensity on T2-weighted images. In tubal pregnancy, an enhanced tubal wall on postcontrast images may be another diagnostic finding. Ruptured EP is inevitably associated with acute hematoma outside these structures. In intrauterine EP, recognition of the relationship between GS-like structure and the myometrium can aid in differentiating from normal pregnancy. Diagnostic pitfalls include heterotopic pregnancy, decidual changes in endometrial cyst and theca lutein cysts mimicking GS-like structures. Knowledge of a spectrum of clinical and MRI features of EP is essential for establishing an accurate diagnosis and determining appropriate management. (orig.)

  17. Temporal Feature Integration for Music Organisation

    DEFF Research Database (Denmark)

    Meng, Anders

    2006-01-01

    This Ph.D. thesis focuses on temporal feature integration for music organisation. Temporal feature integration is the process of combining all the feature vectors of a given time-frame into a single new feature vector in order to capture relevant information in the frame. Several existing methods...... for handling sequences of features are formulated in the temporal feature integration framework. Two datasets for music genre classification have been considered as valid test-beds for music organisation. Human evaluations of these, have been obtained to access the subjectivity on the datasets. Temporal...... feature integration has been used for ranking various short-time features at different time-scales. This include short-time features such as the Mel frequency cepstral coefficients (MFCC), linear predicting coding coefficients (LPC) and various MPEG-7 short-time features. The ‘consensus sensitivity...

  18. Peter & Jane: A Program Showcase

    Science.gov (United States)

    Kalinowski, Michael

    2008-01-01

    This article features the early childhood programs at Peter & Jane Kindergarten located in Petaling Java, Malaysia. The primary purpose of the programs is to lay a strong foundation for a lifelong love of learning in each child. According to principal Patricia Teh, the activities are funded by parent fees and serve children two to six years of…

  19. Featured Invention: Laser Scaling Device

    Science.gov (United States)

    Dunn, Carol Anne

    2008-01-01

    In September 2003, NASA signed a nonexclusive license agreement with Armor Forensics, a subsidiary of Armor Holdings, Inc., for the laser scaling device under the Innovative Partnerships Program. Coupled with a measuring program, also developed by NASA, the unit provides crime scene investigators with the ability to shoot photographs at scale without having to physically enter the scene, analyzing details such as bloodspatter patterns and graffiti. This ability keeps the scene's components intact and pristine for the collection of information and evidence. The laser scaling device elegantly solved a pressing problem for NASA's shuttle operations team and also provided industry with a useful tool. For NASA, the laser scaling device is still used to measure divots or damage to the shuttle's external tank and other structures around the launchpad. When the invention also met similar needs within industry, the Innovative Partnerships Program provided information to Armor Forensics for licensing and marketing the laser scaling device. Jeff Kohler, technology transfer agent at Kennedy, added, "We also invited a representative from the FBI's special photography unit to Kennedy to meet with Armor Forensics and the innovator. Eventually the FBI ended up purchasing some units. Armor Forensics is also beginning to receive interest from DoD [Department of Defense] for use in military crime scene investigations overseas."

  20. Object-oriented Programming Laws for Annotated Java Programs

    Directory of Open Access Journals (Sweden)

    Gabriel Falconieri Freitas

    2010-03-01

    Full Text Available Object-oriented programming laws have been proposed in the context of languages that are not combined with a behavioral interface specification language (BISL. The strong dependence between source-code and interface specifications may cause a number of difficulties when transforming programs. In this paper we introduce a set of programming laws for object-oriented languages like Java combined with the Java Modeling Language (JML. The set of laws deals with object-oriented features taking into account their specifications. Some laws deal only with features of the specification language. These laws constitute a set of small transformations for the development of more elaborate ones like refactorings.

  1. Text Mining in Python through the HTRC Feature Reader

    Directory of Open Access Journals (Sweden)

    Peter Organisciak

    2016-11-01

    Full Text Available We introduce a toolkit for working with the 13.6 million volume Extracted Features Dataset from the HathiTrust Research Center. You will learn how to peer at the words and trends of any book in the collection, while developing broadly useful Python data analysis skills. The HathiTrust holds nearly 15 million digitized volumes from libraries around the world. In addition to their individual value, these works in aggregate are extremely valuable for historians. Spanning many centuries and genres, they offer a way to learn about large-scale trends in history and culture, as well as evidence for changes in language or even the structure of the book. To simplify access to this collection the HathiTrust Research Center (HTRC has released the Extracted Features dataset (Capitanu et al. 2015: a dataset that provides quantitative information describing every page of every volume in the collection. In this lesson, we introduce the HTRC Feature Reader, a library for working with the HTRC Extracted Features dataset using the Python programming language. The HTRC Feature Reader is structured to support work using popular data science libraries, particularly Pandas. Pandas provides simple structures for holding data and powerful ways to interact with it. The HTRC Feature Reader uses these data structures, so learning how to use it will also cover general data analysis skills in Python.

  2. Feature Selection Based on Confidence Machine

    OpenAIRE

    Liu, Chang; Xu, Yi

    2014-01-01

    In machine learning and pattern recognition, feature selection has been a hot topic in the literature. Unsupervised feature selection is challenging due to the loss of labels which would supply the related information.How to define an appropriate metric is the key for feature selection. We propose a filter method for unsupervised feature selection which is based on the Confidence Machine. Confidence Machine offers an estimation of confidence on a feature'reliability. In this paper, we provide...

  3. Toward Automated Feature Detection in UAVSAR Images

    Science.gov (United States)

    Parker, J. W.; Donnellan, A.; Glasscoe, M. T.

    2014-12-01

    Edge detection identifies seismic or aseismic fault motion, as demonstrated in repeat-pass inteferograms obtained by the Uninhabited Aerial Vehicle Synthetic Aperture Radar (UAVSAR) program. But this identification is not robust at present: it requires a flattened background image, interpolation into missing data (holes) and outliers, and background noise that is either sufficiently small or roughly white Gaussian. Identification and mitigation of nongaussian background image noise is essential to creating a robust, automated system to search for such features. Clearly a robust method is needed for machine scanning of the thousands of UAVSAR repeat-pass interferograms for evidence of fault slip, landslides, and other local features.Empirical examination of detrended noise based on 20 km east-west profiles through desert terrain with little tectonic deformation for a suite of flight interferograms shows nongaussian characteristics. Statistical measurement of curvature with varying length scale (Allan variance) shows nearly white behavior (Allan variance slope with spatial distance from roughly -1.76 to -2) from 25 to 400 meters, deviations from -2 suggesting short-range differences (such as used in detecting edges) are often freer of noise than longer-range differences. At distances longer than 400 m the Allan variance flattens out without consistency from one interferogram to another. We attribute this additional noise afflicting difference estimates at longer distances to atmospheric water vapor and uncompensated aircraft motion.Paradoxically, California interferograms made with increasing time intervals before and after the El Mayor Cucapah earthquake (2008, M7.2, Mexico) show visually stronger and more interesting edges, but edge detection methods developed for the first year do not produce reliable results over the first two years, because longer time spans suffer reduced coherence in the interferogram. The changes over time are reflecting fault slip and block

  4. Kernel-based Joint Feature Selection and Max-Margin Classification for Early Diagnosis of Parkinson’s Disease

    Science.gov (United States)

    Adeli, Ehsan; Wu, Guorong; Saghafi, Behrouz; An, Le; Shi, Feng; Shen, Dinggang

    2017-01-01

    Feature selection methods usually select the most compact and relevant set of features based on their contribution to a linear regression model. Thus, these features might not be the best for a non-linear classifier. This is especially crucial for the tasks, in which the performance is heavily dependent on the feature selection techniques, like the diagnosis of neurodegenerative diseases. Parkinson’s disease (PD) is one of the most common neurodegenerative disorders, which progresses slowly while affects the quality of life dramatically. In this paper, we use the data acquired from multi-modal neuroimaging data to diagnose PD by investigating the brain regions, known to be affected at the early stages. We propose a joint kernel-based feature selection and classification framework. Unlike conventional feature selection techniques that select features based on their performance in the original input feature space, we select features that best benefit the classification scheme in the kernel space. We further propose kernel functions, specifically designed for our non-negative feature types. We use MRI and SPECT data of 538 subjects from the PPMI database, and obtain a diagnosis accuracy of 97.5%, which outperforms all baseline and state-of-the-art methods.

  5. The Machine / Job Features Mechanism

    Energy Technology Data Exchange (ETDEWEB)

    Alef, M. [KIT, Karlsruhe; Cass, T. [CERN; Keijser, J. J. [NIKHEF, Amsterdam; McNab, A. [Manchester U.; Roiser, S. [CERN; Schwickerath, U. [CERN; Sfiligoi, I. [Fermilab

    2017-11-22

    Within the HEPiX virtualization group and the Worldwide LHC Computing Grid’s Machine/Job Features Task Force, a mechanism has been developed which provides access to detailed information about the current host and the current job to the job itself. This allows user payloads to access meta information, independent of the current batch system or virtual machine model. The information can be accessed either locally via the filesystem on a worker node, or remotely via HTTP(S) from a webserver. This paper describes the final version of the specification from 2016 which was published as an HEP Software Foundation technical note, and the design of the implementations of this version for batch and virtual machine platforms. We discuss early experiences with these implementations and how they can be exploited by experiment frameworks.

  6. PERPETUAL LEASE: FEATURES OF ACCOUNTING

    Directory of Open Access Journals (Sweden)

    Tetiana Yurchenko

    2017-03-01

    Full Text Available The article namely deals with the peculiarities of legal regulation of the right to use someone else's land for agricultural purposes under the perpetual lease contract. Recognition of the legitimacy of perpetual lease as an intangible asset and, therefore, the object of accounting was justified. The features of the primary account perpetual lease rights were analyzed. It was found that for documenting transactions receipt, commissioning, de-recognition perpetual lease specialized forms of primary documents is not installed. The main aspects of accounting reflection of land under perpetual lease contracts were identified and ways of their improving were developed. The period on which the land is transferred for use under perpetual lease contract was proposed. During the study, general scientific methods – induction, deduction, synthesis, analysis, dialectical, historical, generalizations and specific methods of accounting – documentation, evaluation, accounting records were used. Keywords: accounting, land, perpetual lease, intangible assets, the right to use.

  7. New learning resource features CERN

    CERN Multimedia

    Katarina Anthony

    2011-01-01

    A new educational website, STEM Works, has been launched this month, presenting science and technology in an industrial context for students aged 11-14. Developed with contributions from CERN, the site highlights the Laboratory as a “real-world” example of the opportunities available to science graduates. While the site was developed in Northern Ireland, STEM Works addresses issues of global relevance.   Students share their projects with Steve Myers, Richard Hanna (CCEA), and Catriona Ruane (Education Minister). STEM stands for Science, Technology, Engineering and Mathematics – the four cornerstones of the curriculum featured on the STEM Works website. It is part of a nationwide push in Northern Ireland to highlight how important STEM subjects are to both academia and industry. CERN worked closely with the Northern Ireland Council for the Curriculum, Examinations and Assessment (CCEA) to develop educational content for the site. “The CCEA STEM Works site i...

  8. Resorbable collagen membranes: histopathologic features.

    Science.gov (United States)

    Almazrooa, Soulafa A; Noonan, Vikki; Woo, Sook-Bin

    2014-08-01

    Resorbable collagen membranes (RCMs) are commonly used by oral surgeons, periodontists, and endodontists for multiple purposes. We report 6 cases of RCMs that did not resorb as expected and describe the histopathologic features. Cases of an unusual fibrillar foreign material were noted in biopsy specimens curetted from bone. Hematoxylin-eosin and Masson trichrome stains were performed. Clinicians were contacted for detailed clinical information. There were 3 men and 3 women. RCMs presented as hyalinized, paucicellular, delicate eosinophilic fibrils or a meshwork without a foreign body reaction. They were refractile and stained for Masson trichrome as expected. These RCMs persisted longer than expected (2-6 weeks) in 3 cases and may have retarded healing in 5 cases. Although RCM is supposed to be fairly rapidly resorbable, this material sometimes persists within wound sites without any obvious foreign body reaction and may retard healing. Copyright © 2014 Elsevier Inc. All rights reserved.

  9. Electron magnetohydrodynamic turbulence: universal features

    Science.gov (United States)

    Shivamoggi, Bhimsen K.

    2015-02-01

    The energy cascade of electron magnetohydrodynamic (EMHD) turbulence is considered. Fractal and multi-fractal models for the energy dissipation field are used to determine the spatial intermittency corrections to the scaling behavior in the high-wavenumber (electron hydrodynamic limit) and low-wavenumber (magnetization limit) asymptotic regimes of the inertial range. Extrapolation of the multi-fractal scaling down to the dissipative microscales confirms in these asymptotic regimes a dissipative anomaly previously indicated by the numerical simulations of EMHD turbulence. Several basic features of the EMHD turbulent system are found to be universal which seem to transcend the existence of the characteristic length scale d e (which is the electron skin depth) in the EMHD problem: equipartition spectrum; Reynolds-number scaling of the dissipative microscales; scaling of the probability distribution function (PDF) of the electron-flow velocity (or magnetic field) gradient (even with intermittency corrections); dissipative anomaly; and critical exponent scaling.

  10. Feature selection for portfolio optimization

    DEFF Research Database (Denmark)

    Bjerring, Thomas Trier; Ross, Omri; Weissensteiner, Alex

    2016-01-01

    Most portfolio selection rules based on the sample mean and covariance matrix perform poorly out-of-sample. Moreover, there is a growing body of evidence that such optimization rules are not able to beat simple rules of thumb, such as 1/N. Parameter uncertainty has been identified as one major...... reason for these findings. A strand of literature addresses this problem by improving the parameter estimation and/or by relying on more robust portfolio selection methods. Independent of the chosen portfolio selection rule, we propose using feature selection first in order to reduce the asset menu....... While most of the diversification benefits are preserved, the parameter estimation problem is alleviated. We conduct out-of-sample back-tests to show that in most cases different well-established portfolio selection rules applied on the reduced asset universe are able to improve alpha relative...

  11. Enhanced feature integration in musicians

    DEFF Research Database (Denmark)

    Hansen, Niels Christian; Højlund, Andreas; Møller, Cecilie

    (MEG) from 25 musicians and 25 non-musicians, exposed to sounds presented in interleaved blocks of a musical multi-feature paradigm and a classical oddball control paradigm. In addition to single deviants differing in pitch (P), intensity (I), or perceived location (L), double and triple deviants were...... of MMNms obtained with the constituent single deviants. Significantly greater MMNm under-additivity was observed in musicians compared to non-musicians, specifically for pitch-related deviants in the musical paradigm (i.e. PI, LP, and, marginally, PIL). Conversely, expertise effects were absent from...... the classical oddball control paradigm which used identical sounds. This novel finding supports the dependent processing hypothesis suggesting that musicians recruit overlapping neural resources facilitating more holistic representations of domain-relevant stimuli. These specialised refinements in predictive...

  12. WCET Analysis of Java Bytecode Featuring Common Execution Environments

    DEFF Research Database (Denmark)

    Luckow, Kasper Søe; Thomsen, Bent; Frost, Christian

    2011-01-01

    We present a novel tool for statically determining the Worst Case Execution Time (WCET) of Java Bytecode-based programs called Tool for Execution Time Analysis of Java bytecode (TetaJ). This tool differentiates itself from existing tools by separating the individual constituents of the execution...... environment into independent components. The prime benefit is that it can be used for execution environments featuring common embedded processors and software implementations of the JVM. TetaJ employs a model checking approach for statically determining WCET where the Java program, the JVM, and the hardware...

  13. Synaptic activity induces dramatic changes in the geometry of the cell nucleus: interplay between nuclear structure, histone H3 phosphorylation, and nuclear calcium signaling.

    Science.gov (United States)

    Wittmann, Malte; Queisser, Gillian; Eder, Anja; Wiegert, J Simon; Bengtson, C Peter; Hellwig, Andrea; Wittum, Gabriel; Bading, Hilmar

    2009-11-25

    Synaptic activity initiates many adaptive responses in neurons. Here we report a novel form of structural plasticity in dissociated hippocampal cultures and slice preparations. Using a recently developed algorithm for three-dimensional image reconstruction and quantitative measurements of cell organelles, we found that many nuclei from hippocampal neurons are highly infolded and form unequally sized nuclear compartments. Nuclear infoldings are dynamic structures, which can radically transform the geometry of the nucleus in response to neuronal activity. Action potential bursting causing synaptic NMDA receptor activation dramatically increases the number of infolded nuclei via a process that requires the ERK-MAP kinase pathway and new protein synthesis. In contrast, death-signaling pathways triggered by extrasynaptic NMDA receptors cause a rapid loss of nuclear infoldings. Compared with near-spherical nuclei, infolded nuclei have a larger surface and increased nuclear pore complex immunoreactivity. Nuclear calcium signals evoked by cytosolic calcium transients are larger in small nuclear compartments than in the large compartments of the same nucleus; moreover, small compartments are more efficient in temporally resolving calcium signals induced by trains of action potentials in the theta frequency range (5 Hz). Synaptic activity-induced phosphorylation of histone H3 on serine 10 was more robust in neurons with infolded nuclei compared with neurons with near-spherical nuclei, suggesting a functional link between nuclear geometry and transcriptional regulation. The translation of synaptic activity-induced signaling events into changes in nuclear geometry facilitates the relay of calcium signals to the nucleus, may lead to the formation of nuclear signaling microdomains, and could enhance signal-regulated transcription.

  14. Intramolecular telomeric G-quadruplexes dramatically inhibit DNA synthesis by replicative and translesion polymerases, revealing their potential to lead to genetic change.

    Directory of Open Access Journals (Sweden)

    Deanna N Edwards

    Full Text Available Recent research indicates that hundreds of thousands of G-rich sequences within the human genome have the potential to form secondary structures known as G-quadruplexes. Telomeric regions, consisting of long arrays of TTAGGG/AATCCC repeats, are among the most likely areas in which these structures might form. Since G-quadruplexes assemble from certain G-rich single-stranded sequences, they might arise when duplex DNA is unwound such as during replication. Coincidentally, these bulky structures when present in the DNA template might also hinder the action of DNA polymerases. In this study, single-stranded telomeric templates with the potential to form G-quadruplexes were examined for their effects on a variety of replicative and translesion DNA polymerases from humans and lower organisms. Our results demonstrate that single-stranded templates containing four telomeric GGG runs fold into intramolecular G-quadruplex structures. These intramolecular G quadruplexes are somewhat dynamic in nature and stabilized by increasing KCl concentrations and decreasing temperatures. Furthermore, the presence of these intramolecular G-quadruplexes in the template dramatically inhibits DNA synthesis by various DNA polymerases, including the human polymerase δ employed during lagging strand replication of G-rich telomeric strands and several human translesion DNA polymerases potentially recruited to sites of replication blockage. Notably, misincorporation of nucleotides is observed when certain translesion polymerases are employed on substrates containing intramolecular G-quadruplexes, as is extension of the resulting mismatched base pairs upon dynamic unfolding of this secondary structure. These findings reveal the potential for blockage of DNA replication and genetic changes related to sequences capable of forming intramolecular G-quadruplexes.

  15. A point mutation in the ion conduction pore of AMPA receptor GRIA3 causes dramatically perturbed sleep patterns as well as intellectual disability.

    Science.gov (United States)

    Davies, Benjamin; Brown, Laurence A; Cais, Ondrej; Watson, Jake; Clayton, Amber J; Chang, Veronica T; Biggs, Daniel; Preece, Christopher; Hernandez-Pliego, Polinka; Krohn, Jon; Bhomra, Amarjit; Twigg, Stephen R F; Rimmer, Andrew; Kanapin, Alexander; Sen, Arjune; Zaiwalla, Zenobia; McVean, Gil; Foster, Russell; Donnelly, Peter; Taylor, Jenny C; Blair, Edward; Nutt, David; Aricescu, A Radu; Greger, Ingo H; Peirson, Stuart N; Flint, Jonathan; Martin, Hilary C

    2017-10-15

    The discovery of genetic variants influencing sleep patterns can shed light on the physiological processes underlying sleep. As part of a large clinical sequencing project, WGS500, we sequenced a family in which the two male children had severe developmental delay and a dramatically disturbed sleep-wake cycle, with very long wake and sleep durations, reaching up to 106-h awake and 48-h asleep. The most likely causal variant identified was a novel missense variant in the X-linked GRIA3 gene, which has been implicated in intellectual disability. GRIA3 encodes GluA3, a subunit of AMPA-type ionotropic glutamate receptors (AMPARs). The mutation (A653T) falls within the highly conserved transmembrane domain of the ion channel gate, immediately adjacent to the analogous residue in the Grid2 (glutamate receptor) gene, which is mutated in the mouse neurobehavioral mutant, Lurcher. In vitro, the GRIA3(A653T) mutation stabilizes the channel in a closed conformation, in contrast to Lurcher. We introduced the orthologous mutation into a mouse strain by CRISPR-Cas9 mutagenesis and found that hemizygous mutants displayed significant differences in the structure of their activity and sleep compared to wild-type littermates. Typically, mice are polyphasic, exhibiting multiple sleep bouts of sleep several minutes long within a 24-h period. The Gria3A653T mouse showed significantly fewer brief bouts of activity and sleep than the wild-types. Furthermore, Gria3A653T mice showed enhanced period lengthening under constant light compared to wild-type mice, suggesting an increased sensitivity to light. Our results suggest a role for GluA3 channel activity in the regulation of sleep behavior in both mice and humans. © The Author 2017. Published by Oxford University Press.

  16. Towards a Unified Programming Language

    DEFF Research Database (Denmark)

    Madsen, Ole Lehrmann

    2000-01-01

    The goal of research in programming languages should be to develop languages that integrates the best of concepts and constructs from the various programming paradigms. We do not argue for a multi-paradigm language, where the programmer alternates between the different paradigms/styles. Instead, we...... style and where more research is needed. In addition to traditional paradigms such as object-oriented-, imperative-functional- and logic programming, we also discuss concurrent programming and prototype-based programming. We discuss language features such as the BETA pattern construct, virtual...

  17. Line-Editor Computer Program

    Science.gov (United States)

    Scott, Peter J.

    1989-01-01

    ZED editing program for DEC VAX computer simple, powerful line editor for text, program source code, and nonbinary data. Excels in processing of text by use of procedure files. Also features versatile search qualifiers, global changes, conditionals, online help, hexadecimal mode, space compression, looping, logical combinations of search strings, journaling, visible control characters, and automatic detabbing. Users of Cambridge implementation devised such ZED procedures as chess games, calculators, and programs for evaluating pi. Written entirely in C.

  18. Aspect-Oriented Programming

    Science.gov (United States)

    Elrad, Tzilla (Editor); Filman, Robert E. (Editor); Bader, Atef (Editor)

    2001-01-01

    Computer science has experienced an evolution in programming languages and systems from the crude assembly and machine codes of the earliest computers through concepts such as formula translation, procedural programming, structured programming, functional programming, logic programming, and programming with abstract data types. Each of these steps in programming technology has advanced our ability to achieve clear separation of concerns at the source code level. Currently, the dominant programming paradigm is object-oriented programming - the idea that one builds a software system by decomposing a problem into objects and then writing the code of those objects. Such objects abstract together behavior and data into a single conceptual and physical entity. Object-orientation is reflected in the entire spectrum of current software development methodologies and tools - we have OO methodologies, analysis and design tools, and OO programming languages. Writing complex applications such as graphical user interfaces, operating systems, and distributed applications while maintaining comprehensible source code has been made possible with OOP. Success at developing simpler systems leads to aspirations for greater complexity. Object orientation is a clever idea, but has certain limitations. We are now seeing that many requirements do not decompose neatly into behavior centered on a single locus. Object technology has difficulty localizing concerns invoking global constraints and pandemic behaviors, appropriately segregating concerns, and applying domain-specific knowledge. Post-object programming (POP) mechanisms that look to increase the expressiveness of the OO paradigm are a fertile arena for current research. Examples of POP technologies include domain-specific languages, generative programming, generic programming, constraint languages, reflection and metaprogramming, feature-oriented development, views/viewpoints, and asynchronous message brokering. (Czarneclu and

  19. Systematic feature analysis on timber defect images

    Directory of Open Access Journals (Sweden)

    Ummi Rabaah Hashim

    2017-07-01

    Full Text Available Feature extraction is unquestionably an important process in a pattern recognition system. A defined set of features makes the identification task more efficiently. This paper addresses the extraction and analysis of features based on statistical texture to characterize images of timber defects. A series of procedures including feature extraction and feature analysis was executed to construct an appropriate feature set that could significantly separate amongst defects and clear wood classes. The feature set aimed for later use in a timber defect detection system. For Accessing the discrimination capability of the features extracted, visual exploratory analysis and confirmatory statistical analysis were performed on defect and clear wood images of Meranti (Shorea spp. timber species. Results from the analysis demonstrated that there was a significant distinction between defect classes and clear wood utilizing the proposed set of texture features.

  20. Language identification using spectral and prosodic features

    CERN Document Server

    Rao, K Sreenivasa; Maity, Sudhamay

    2015-01-01

    This book discusses the impact of spectral features extracted from frame level, glottal closure regions, and pitch-synchronous analysis on the performance of language identification systems. In addition to spectral features, the authors explore prosodic features such as intonation, rhythm, and stress features for discriminating the languages. They present how the proposed spectral and prosodic features capture the language specific information from two complementary aspects, showing how the development of language identification (LID) system using the combination of spectral and prosodic features will enhance the accuracy of identification as well as improve the robustness of the system. This book provides the methods to extract the spectral and prosodic features at various levels, and also suggests the appropriate models for developing robust LID systems according to specific spectral and prosodic features. Finally, the book discuss about various combinations of spectral and prosodic features, and the desire...

  1. Representation and Metrics Extraction from Feature Basis: An Object Oriented Approach

    Directory of Open Access Journals (Sweden)

    Fausto Neri da Silva Vanin

    2010-10-01

    Full Text Available This tutorial presents an object oriented approach to data reading and metrics extraction from feature basis. Structural issues about basis are discussed first, then the Object Oriented Programming (OOP is aplied to modeling the main elements in this context. The model implementation is then discussed using C++ as programing language. To validate the proposed model, we apply on some feature basis from the University of Carolina, Irvine Machine Learning Database.

  2. EZLP: An Interactive Computer Program for Solving Linear Programming Problems. Final Report.

    Science.gov (United States)

    Jarvis, John J.; And Others

    Designed for student use in solving linear programming problems, the interactive computer program described (EZLP) permits the student to input the linear programming model in exactly the same manner in which it would be written on paper. This report includes a brief review of the development of EZLP; narrative descriptions of program features,…

  3. The Edgerton Structure: A Possible Meteorite Impact Feature in Eastern Kansas

    Directory of Open Access Journals (Sweden)

    Daniel F. Merriam

    2009-01-01

    Full Text Available Recognized meteorite impact features are relatively rare in the U.S. Midcontinent region, but recently with increased interest and research, the number has increased dramatically. We add another possibility to the growing list, the Edgerton structure in northwestern Miami County, Kansas. The feature is elliptical (∼5.5 × 6.5 km, slightly elongated east-west with radial surface drainage. The feature was first observed on hillshade maps of digitized topography of 7.5 minute quadrangles. Subsequent magnetic profiles show a higher magnetic value in the center of the ellipse with higher values around the edges; this shape is characteristic of an impact feature. Depth to the anomalous body is estimated to be about 1 km, which puts it in the Precambrian crystalline basement under a cover of Paleozoic sediments. There are no deep boreholes in the vicinity and no seismic profiles are available. If it is an impact structure, it will be the second such feature documented in Kansas, the first being the Brenham meteorite crater at Haviland in Kiowa County in southwestern Kansas. It would be older than the other impact structures identified in the Midcontinent—Manson in Iowa, Ames in Oklahoma, Haswell Hole in Colorado, and possibly Belton in Missouri and Merna in Nebraska. There are at least two other prospective impact features in Kansas: the Goddard ring west of Wichita and Garden City ellipse north-west of Garden City.

  4. Temporal feature integration for music genre classification

    DEFF Research Database (Denmark)

    Meng, Anders; Ahrendt, Peter; Larsen, Jan

    2007-01-01

    , but they capture neither the temporal dynamics nor dependencies among the individual feature dimensions. Here, a multivariate autoregressive feature model is proposed to solve this problem for music genre classification. This model gives two different feature sets, the diagonal autoregressive (DAR......) and multivariate autoregressive (MAR) features which are compared against the baseline mean-variance as well as two other temporal feature integration techniques. Reproducibility in performance ranking of temporal feature integration methods were demonstrated using two data sets with five and eleven music genres...

  5. Status of Iran's nuclear program and negotiations

    Science.gov (United States)

    Albright, David

    2014-05-01

    Iran's nuclear program poses immense challenges to international security. Its gas centrifuge program has grown dramatically in the last several years, bringing Iran close to a point where it could produce highly enriched uranium in secret or declared gas centrifuge plants before its breakout would be discovered and stopped. To reduce the risk posed by Iran's nuclear program, the P5+1 have negotiated with Iran short term limits on the most dangerous aspects of its nuclear programs and is negotiating long-term arrangements that can provide assurance that Iran will not build nuclear weapons. These long-term arrangements need to include a far more limited and transparent Iranian nuclear program. In advance of arriving at a long-term arrangement, the IAEA will need to resolve its concerns about the alleged past and possibly on-going military dimensions of Iran's nuclear program.

  6. Federal Educational Assistance Programs Available to Service Members: Program Features and Recommendations for Improved Delivery

    Science.gov (United States)

    2015-01-01

    borrowers were enrolled in school and therefore eligible to defer loan repayment and interest accrual (Dynarksi, Hemelt, and Hyman , 2013). For the...percent of private, for-profit insti- tutions (Dynarksi, Hemelt, and Hyman , 2013, pp.  32, 38).1 As mentioned at the end of Chapter Two, a substantial...enrolled, persistence rates for enrollees from one year to the next, and fields of study or majors (Dynarksi, Hemelt, and Hyman , 2013). Although some

  7. Pleomorphic xanthoastrocytoma with anaplastic features

    Directory of Open Access Journals (Sweden)

    Cheng ZHI

    2015-08-01

    Full Text Available Objective  To explore the clinical pathological characteristics, immunophenotyping, diagnosis and differential diagnosis and prognosis of pleomorphic xanthoastrocytoma (PXA with anaplastic features.  Methods  HE staining was used for histological observation. The expressions of glial fibrillary acidic protein (GFAP, vimentin (Vim, CD34, epithelial membrane antigen (EMA, progestrone receptor (PR, neurofilment protein (NF, neuronal nuclei (NeuN, synaptophysin (Syn, Nestin (Nes, S-100 protein (S-100, P53 and Ki-67 labeling index were detected by immunohistochemical method. BRAF mutation was detected by polymerase chain reaction (PCR amplification.  Results  A 43-year-old male patient presented with repeatedly paroxysmal tic of limbs and disturbance of consciousness. Cranial MRI revealed multiple abnormal signals in left temporo-occipito-parietal lobe and posterior horn of lateral ventricle, with unclear borderline and cystic degeneration. Surgical removal of the lesion was performed. Histologically, the tumor was biphasic. One part was composed of spindle cells arranged in fascicles or as running water, with weird multinuclear giant cells. Abundant vacuolated lipidized cytoplasm could be seen. Mitosis and "map"-like necrosis were noted. Another part revealed the tumor cells were consistent in size and uniform in distribution, with loose background tissue. Immunohistochemistry showed tumor cells were diffusely positive for GFAP, Vim, S-100, Nes, CD34 and P53, and negative for EMA, Syn, NeuN and NF. Ki-67 labeling index was about 15%. Reticular fiber staining showed abundant reticular fibers in the tumor tissue. BRAF mutation detected by PCR amplification was not found.  Conclusions  Classified as grade Ⅱ in the World Health Organization (WHO classification, the prognosis of PXA is good. A diagnosis of PXA with anaplastic features should be considered when the tumor demonstrates mitotic activity > 5/10 high power field (HPF and/or areas of

  8. Sclerosing nevus with pseudomelanomatous features.

    Science.gov (United States)

    Fabrizi, Giuseppe; Pennacchia, Ilaria; Pagliarello, Calogero; Massi, Guido

    2008-11-01

    Among the pigmented lesions with a central area of scar, we found a group of cases histologically characterized by striking architectural alteration of the melanocytic component, but with no cytological atypia and mitotically quiescent. The aim of the current study was to assess the biological nature of such lesions. We selected 19 of these melanocytic neoplasms that had the following characteristics: (a) a clinically evident whitish central area suggestive of regression (with no history of a previous surgical procedure or trauma), (b) histological features of fibrous scar-like tissue at the center of the lesion, (c) the presence of large, confluent and unusually shaped melanocytic nests at the dermoepidermal junction and in the dermis, (d) a pagetoid spread of melanocytes above the epidermal basal layer and (e) remnants of nevus tissue at the border of the scar. The lesions showed no evidence of cytological atypia, expansive nodules of melanocytes, significant numbers of mitoses or cellular necrosis. All the cases have been followed up and none have recurred or metastasized. Histologically, these neoplasms have important similarities with the so-called recurrent nevus, nevi on lichen sclerosus and nevi developed during or following cutaneous inflammatory and sclerosing processes. The origin of the scar in each case was obscure but was probably related to minor unnoticed trauma or to chronic friction on a nevus. In few cases, the fibrosis was probably the result of partial regression of the nevus or a sequel to folliculitis. The pseudomelanomatous features appear to be related to the presence of the scar, as already reported for nevi that are involved in fibrotic or scarring processes. In our study, the nevi involved in the fibrotic process were congenital nevi and common or dysplastic nevi. One case was a Spitz nevus. From our data we concluded that, despite their worrisome clinical and histological aspect, the lesions described in this case series were most

  9. Landscapes of the mind: postdramatic features in Brian Friel's Molly SweeneyDOI:10.5007/2175-8026.2010n58p113

    Directory of Open Access Journals (Sweden)

    Anna Stegh Camati

    2010-01-01

    Full Text Available The contemporary debate regarding the new languages of the stage has developed into multiple directions. In Molly Sweeney (1994, Brian Friel rejects dramatic progression and interpersonal dialogue to privilege direct interaction with the audience that intensifies the production of presence. He combines conventional and postdramatic features in his presentation of alternating monologues by three speakers - Molly, Frank and Mr. Rice - whose solo voices create an allegory on the unwillingness of communication in our time. The emerging landscapes of the mind force the audience to deal with the indeterminacy of meaning, extending representation beyond dramatic action in the theatre.

  10. Bifacial Perovskite Solar Cells Featuring Semitransparent Electrodes.

    Science.gov (United States)

    Hanmandlu, Chintam; Chen, Chien-Yu; Boopathi, Karunakara Moorthy; Lin, Hao-Wu; Lai, Chao-Sung; Chu, Chih-Wei

    2017-09-27

    Inorganic-organic hybrid perovskite solar cells (PSCs) are promising devices for providing future clean energy because of their low cost, ease of fabrication, and high efficiencies, similar to those of silicon solar cells. These materials have been investigated for their potential use in bifacial PSCs, which can absorb light from both sides of the electrodes. Here, we fabricated bifacial PSCs featuring transparent BCP/Ag/MoO3 rear electrodes, which we formed through low-temperature processing using thermal evaporation methods. We employed a comprehensive optical distribution program to calculate the distributions of the optical field intensities with constant thicknesses of the absorbing layer in the top electrode configuration. The best PSC having a transparent BCP/Ag/MoO3 electrode achieved PCEs of 13.49% and 9.61% when illuminated from the sides of the indium tin oxide and BCP/Ag/MoO3 electrodes, respectively. We observed significant power enhancement when operating this PSC using mirror reflectors and bifacial light illumination from both sides of the electrodes.

  11. Sonographic Features of Colonic Diverticulitis

    Energy Technology Data Exchange (ETDEWEB)

    Jeong, Yu Mee; Ko, Young Tae; Lim, Joo Won; Lee, Dong Ho; Yoon, Yup [Kyung Hee University Hospital, Seoul (Korea, Republic of)

    1996-06-15

    To evaluate sonographic features, location of diverticulum, and usefulness of sonography as a primary diagnostic tool. Sonographic findings of 28 patients with acute diverticulitis were reviewed. The diagnosis was made by surgery (11 patients), barium enema (20 patients), colonoscopy (3 patients), or CT (2 patients). There were 13 men and 15 women with ages ranging from 23 to 71 years old (mean, 33 years old). Sonographic abnormalities were seen in the cecum in 12 patients, both the cecum and ascending colon in seven, the ascending colon in six, the descending colon in two, and the transverse colon in one. On sonography, segmental thickening of the colonic wall was the most common finding, seen in 16 patients. The second most common finidngs were pericolic omental thickening and pericolic localized fluid collection (15 patients). Pericolic inflammatory mass of varying echogenicity (10 patients), out pouching hyper echoic foci beyond the lumen of the colon into or beyond the thickened wall (5 patients), contracture of the colon (5 patients), slightly thickened terminal ileum (1 patient), and local enlargement of ileocecal lymph node (1 patient) were also seen. Most diverticulitis occurred in the right colon. The useful sonographic findings in acute diverticulitis were echogenic foci of the diverticulum in the thickened colonic wall, focally and eccentrically thickened colonic wall, and localized omental thickening or fluid collection. In cases of pericecal fluid collection, appendicitis or colonic diverticulitis can be considered as a differential diagnosis

  12. Ocular features of CHARGE syndrome.

    Science.gov (United States)

    McMain, Karen; Blake, Kim; Smith, Isabel; Johnson, Judy; Wood, Ellen; Tremblay, Francois; Robitaille, Johane

    2008-10-01

    To detail the presence and severity of ocular and cranial nerve abnormalities found in individuals with CHARGE syndrome in a distinct geographic area. Nine individuals with CHARGE syndrome from Maritime Canada identified from a Canadian database were prospectively examined. Structural and sensorial defects associated with functional visual deficits were defined with ophthalmic and neurological evaluation. Consistent with current diagnostic criteria and the literature, colobomas were the major ophthalmic manifestation. These were typically bilateral chorioretinal colobomas involving the optic nerve. All subjects had bilateral severe sensorineural deafness (cranial nerve VIII), and 8 of 9 (89%) had facial nerve (cranial nerve VII) involvement (7 of 9 had unilateral involvement; 1 of 9 had bilateral involvement). Unique to this group of participants were the findings of anisometropia in 8 of the 9 (89%) patients, severe myopic astigmatism in 13 of the 18 eyes (72%), and limited elevation in adduction in 3 of 9 (33%) participants. Associated findings were strabismus, cataracts, microcornea, keratopathy, staphyloma, reduced stereopsis, superior visual field defects, and reduced visual acuity. The presence of coloboma plus another CHARGE feature warrants further investigation, including genetic screening for the CHD7 gene. Early recognition and management of sensory problems (visual, auditory, and vestibular) are crucial to ensure best psychomotor and cognitive development.

  13. CT features of appendiceal mucocele

    Energy Technology Data Exchange (ETDEWEB)

    Yu, Won Jong; Byun, Jae Young; Jung, Jung Im; Lee, Hae Gyu; Park, Young Ha; Shin, Kyung Sub [Catholic University Medical College, Seoul (Korea, Republic of)

    1995-10-15

    To evaluate the usefulness of CT features of appendiceal mucocele in the diagnosis and evaluation of complications. We retrospectively reviewed CT findings and compared with operative findings in 7 cases of pathologically proven appendiceal mucocele. CT findings such as location and extent of the lesion, tissue density, thickness or calcification of the wall, presence of adjacent inflammatory infiltration, and visualization of normal vermiform appendix were analyzed. Appendiceal mucocele was found as homogeneous low density cystic mass adjacent to the cecum, which has no surrounding inflammatory infiltration except in one case of perforation and one case of intussusception. Mean CT number measured in 4 cases was 21 Hounsfield unit. Thin curvilinear calcifications were noted along the cystic wall in 2 cases. Normal vermiform appendix couldn't be demonstrated in all cases. Appendiceal mucocele is characterized by homogeneously low density and thin walled cystic tumor adjacent to cecum without surrounding inflammatory infiltration, and absence of normal vermiform appendix on CT. Therefore, CT is valuable in preventing operative complications of appendiceal mucocele.

  14. features using RBF-SA

    Directory of Open Access Journals (Sweden)

    Rafael do Espírito Santo

    2006-01-01

    Full Text Available We present in this work a new type of classes discriminator based upon nonlinear and combinational optimization techniques: radial basis functions-simulated annealing (RBF-SA. The combinational optimization method is used here as a preestimation of some parameters of the network classifier. We compare the classifier performance with and without pre-estimation. For training the classifiers, adopting the leave-one-out procedure, we have used case examples such as mammographic masses (malignant and benign. The classifier is trained with shape factors and edge-sharpness measures extracted from 57 regions of interest (ROI (37 malignant and 20 benign, manually delineated, that describe mammographic masses and tumor features in terms of polygonal models for shape factors (compactness [CC], Fourier description [FF], fractional concavity [FCC] and speculated index [SI] and edge sharpness-acutance (A . The classifier performance is compared in terms of the area under the receive operating characteristic (ROC curve – (A. Higher values of A correspond to a better performance of classifier. Experiments with mammographic tumor and masses show that the best result of 0.9776 is obtained with RBF-SA when RBF parameters such as centers and spread matrix are pre-estimated, which is significantly better than the results obtained with no pre-estimation or only pre-estimation of the RBF centers, which are, 0.7071 and 0.9552 respectively.

  15. PHISICS: New Features and Advancements

    Energy Technology Data Exchange (ETDEWEB)

    C. Rabiti; Y. Wang; G. Palmiotti; H. Hiruta; J. Cogliati; A. Alfonsi; A. EPiney; T. Grimmett

    2011-06-01

    The PHISICS (Parallel and Highly Innovative Simulation for INL Code System) software is under an intensive development at INL. In the last months new features have been added and improvements of the previously existing one performed. The modular approach has created a friendly development environment that allows a quick expansion of the capabilities. In the last months a little amount of work has been dedicated to the improvement of the spherical harmonics based nodal transport solver while the implementation of a solver based on the self adjoint formulation of the discrete ordinate is in the test phase on structured mesh. PHISICS now include a depletion solver with the option to use two different algorithms for the solution of the Bateman equation: the Taylor development of the exponential matrix and the Chebyshev Rational Approximation Method. The coupling with RELAP5 is also available at least in the steady state search mode. The coupling between RELAP5 and PHISICS can also take advantage of the new cross section interpolation module so that the coupling could be performed using an arbitrary number of energy groups.

  16. Surface Features of Nanocrystalline Alloys

    Directory of Open Access Journals (Sweden)

    Marcel Miglierini

    2015-12-01

    Full Text Available Nanocrystalline alloys are prepared by controlled annealing of metallic glass precursors. The latter are obtained by rapid quenching of a melt on a rotating wheel. This process leads to structural deviation of the produced ribbons’ surfaces. Structural features of as-quenched and thermally annealed 57Fe81Mo8Cu1B10 ribbons were studied employing Conversion Electron Mössbauer Spectrometry (CEMS and Conversion X-ray Mössbauer Spectrometry (CXMS. Enrichment of the alloy’s composition in 57Fe helped in identification of surface crystallites that were formed even during the production process. Magnetite and bcc-Fe were found at the wheel side of the as-quenched ribbons whereas only bcc-Fe nanocrystals were uncovered at the opposite air side. Accelerated formation of bcc-Fe was observed in this side of the ribbons after annealing. The relative content of magnetite at the wheel side was almost stable in near surface areas (CEMS and in more deep subsurface regions (CXMS. It vanished completely after annealing at 550 °C. No magnetite was observed at the air side of the ribbons regardless the annealing temperature and/or depth of the scanned regions.

  17. Computer Program Newsletter No. 7

    Energy Technology Data Exchange (ETDEWEB)

    Magnuson, W.G. Jr.

    1982-09-01

    This issue of the Computer Program Newsletter updates an earlier newsletter (Number 2, September 1979) and focuses on electrical network analysis computer programs. In particular, five network analysis programs (SCEPTRE, SPICE2, NET2, CALAHAN, and EMTP) will be described. The objective of this newsletter will be to provide a very brief description of the input syntax and semantics for each program, highlight their strong and weak points, illustrate how the programs are run at Lawrence Livermore National Laboratory using the Octopus computer network, and present examples of input for each of the programs to illustrate some of the features of each program. In a sense, this newsletter can be used as a quick reference guide to the programs.

  18. Cascaded face alignment via intimacy definition feature

    Science.gov (United States)

    Li, Hailiang; Lam, Kin-Man; Chiu, Man-Yau; Wu, Kangheng; Lei, Zhibin

    2017-09-01

    Recent years have witnessed the emerging popularity of regression-based face aligners, which directly learn mappings between facial appearance and shape-increment manifolds. We propose a random-forest based, cascaded regression model for face alignment by using a locally lightweight feature, namely intimacy definition feature. This feature is more discriminative than the pose-indexed feature, more efficient than the histogram of oriented gradients feature and the scale-invariant feature transform feature, and more compact than the local binary feature (LBF). Experimental validation of our algorithm shows that our approach achieves state-of-the-art performance when testing on some challenging datasets. Compared with the LBF-based algorithm, our method achieves about twice the speed, 20% improvement in terms of alignment accuracy and saves an order of magnitude on memory requirement.

  19. Historical Climate Change in Sardinia (Italy): The dramatic runoff decrease in the last three decades and the effect of atmospheric circulation.

    Science.gov (United States)

    Montaldo, N.; Sarigu, A.

    2016-12-01

    In the last decades, climate change increased desertification process in Mediterranean regions, with dramatic consequences for agriculture and water availability. The position of the Sardinia island in the center of the western Mediterranean sea basin, its low urbanization and human activity and the interesting hydrologic database collected for the whole region from 1922 appoint Sardinia as a perfect reference laboratory for Mediterranean ecosystems studies and for investigating the impact of historical climate change on main hydrologic variables. Runoff data of 28 Sardinian basins are analyzed, showing a strong runoff decrease for all the basins in the last 40 years (hystorical trends are detected using the Mann Kendall test). Runoff decrease is mainly related to precipitation. We collect an innovative database of rainfall observations from 400 rain stations. The precipitation historical trend is still negative but the decrease is lower than the runoff decrease. This is because main runoff is in winter, which also plays a key role for the dam water supply, and winter precipitation shows a systematic stronger decrease. Interestingly, the decrease is more marked for the rain and discharge stations of the Sardinian west coast, which are exposed to the west European climate dynamics. In this sense, several studies have shown a significant correlation between the main meteorological variables and indices related to fluctuations in global scale, NAO (North Atlantic Oscillation) in Mediterranean regions, which controls the direction and strength of westerly winds and storm tracks into Europe. We found high negative correlations between NAO and precipitation and runoff during the winter season, and the correlations decrease with the increase of rain station longitudes. The results show a strong negative correlation at the stations of the Sardinian west coast, which is due to the exposure to the storm track dynamics. Instead a less negative correlation has been estimated

  20. Dramatic variability of the carbonate system at a temperate coastal ocean site (Beaufort, North Carolina, USA is regulated by physical and biogeochemical processes on multiple timescales.

    Directory of Open Access Journals (Sweden)

    Zackary I Johnson

    Full Text Available Increasing atmospheric carbon dioxide (CO2 from anthropogenic sources is acidifying marine environments resulting in potentially dramatic consequences for the physical, chemical and biological functioning of these ecosystems. If current trends continue, mean ocean pH is expected to decrease by ~0.2 units over the next ~50 years. Yet, there is also substantial temporal variability in pH and other carbon system parameters in the ocean resulting in regions that already experience change that exceeds long-term projected trends in pH. This points to short-term dynamics as an important layer of complexity on top of long-term trends. Thus, in order to predict future climate change impacts, there is a critical need to characterize the natural range and dynamics of the marine carbonate system and the mechanisms responsible for observed variability. Here, we present pH and dissolved inorganic carbon (DIC at time intervals spanning 1 hour to >1 year from a dynamic, coastal, temperate marine system (Beaufort Inlet, Beaufort NC USA to characterize the carbonate system at multiple time scales. Daily and seasonal variation of the carbonate system is largely driven by temperature, alkalinity and the balance between primary production and respiration, but high frequency change (hours to days is further influenced by water mass movement (e.g. tides and stochastic events (e.g. storms. Both annual (~0.3 units and diurnal (~0.1 units variability in coastal ocean acidity are similar in magnitude to 50 year projections of ocean acidity associated with increasing atmospheric CO2. The environmental variables driving these changes highlight the importance of characterizing the complete carbonate system rather than just pH. Short-term dynamics of ocean carbon parameters may already exert significant pressure on some coastal marine ecosystems with implications for ecology, biogeochemistry and evolution and this shorter term variability layers additive effects and

  1. The NS1 Glycoprotein Can Generate Dramatic Antibody-Enhanced Dengue Viral Replication in Normal Out-Bred Mice Resulting in Lethal Multi-Organ Disease

    Science.gov (United States)

    Falconar, Andrew K. I.; Martinez, Fernando

    2011-01-01

    Antibody-enhanced replication (AER) of dengue type-2 virus (DENV-2) strains and production of antibody-enhanced disease (AED) was tested in out-bred mice. Polyclonal antibodies (PAbs) generated against the nonstructural-1 (NS1) glycoprotein candidate vaccine of the New Guinea-C (NG-C) or NSx strains reacted strongly and weakly with these antigens, respectively. These PAbs contained the IgG2a subclass, which cross-reacted with the virion-associated envelope (E) glycoprotein of the DENV-2 NSx strain, suggesting that they could generate its AER via all mouse Fcγ-receptor classes. Indeed, when these mice were challenged with a low dose (AER/AED. These AER/AED mice developed life-threatening acute respiratory distress syndrome (ARDS), displayed by diffuse alveolar damage (DAD) resulting from i) dramatic interstitial alveolar septa-thickening with mononuclear cells, ii) some hyperplasia of alveolar type-II pneumocytes, iii) copious intra-alveolar protein secretion, iv) some hyaline membrane-covered alveolar walls, and v) DENV-2 antigen-positive alveolar macrophages. These mice also developed meningo-encephalitis, with greater than 90,000-fold DENV-2 AER titers in microglial cells located throughout their brain parenchyma, some of which formed nodules around dead neurons. Their spleens contained infiltrated megakaryocytes with DENV-2 antigen-positive red-pulp macrophages, while their livers displayed extensive necrosis, apoptosis and macro- and micro-steatosis, with DENV-2 antigen-positive Kuppfer cells and hepatocytes. Their infections were confirmed by DENV-2 isolations from their lungs, spleens and livers. These findings accord with those reported in fatal human “severe dengue” cases. This DENV-2 AER/AED was blocked by high concentrations of only the NG-C NS1 glycoprotein. These results imply a potential hazard of DENV NS1 glycoprotein-based vaccines, particularly against DENV strains that contain multiple mutations or genetic recombination within or between their

  2. The use of first language scaffolding to teach English as a foreign language to pre-school children during dramatic play in West Sumatera, Indonesia

    Directory of Open Access Journals (Sweden)

    Mulia Dewi

    2015-01-01

    Full Text Available The Indonesian community generally perceives that English language teaching should require phonology, vocabulary, grammar, discourse, and pragmatics. As a result, this often demands that pre-school teachers use English all the time. Code switching between English, Indonesian, and Minang – the local language of the region – is perceived negatively, and teachers are often criticized for using a multilingual approach that is “part snake and part eel” [sakarek ula sakarek baluik]. This refers to a negative perception of mixing languages in educational settings. In fact, code switching between Minang (first language, Indonesian (second language, and English (foreign language is the norm of language use in this part of Indonesia. However, in this community, there is a lack of respect for pre-school teachers' professionalism as well as scepticism towards the effectiveness of a multilingual teaching approach, which is used widely at the pre-school level. Vygotsky [14], the Russian psychologist, presents a different perspective on this phenomenon, noting that children learn languages by playing. Their first language can be the main tool to help them understand new words and utterances in context. By using code switching, teachers help pre-school children to link their prior knowledge and experience to the new forms of expression that enable them to derive the meaning of new words from the social context of language use. For this reason, scaffolding techniques should be used by pre-school teachers, particularly in ways which support children's cognitive development in constructing new meanings based on their first language experience. This paper, based on a research study-in-progress at Deakin University, Melbourne, Australia, explores patterns of interaction between pre-school teachers and their students as teachers scaffold the development of EFL through dramatic play in West Sumatera, Indonesia. This interaction is systemic in nature and

  3. Program specialization

    CERN Document Server

    Marlet, Renaud

    2013-01-01

    This book presents the principles and techniques of program specialization - a general method to make programs faster (and possibly smaller) when some inputs can be known in advance. As an illustration, it describes the architecture of Tempo, an offline program specializer for C that can also specialize code at runtime, and provides figures for concrete applications in various domains. Technical details address issues related to program analysis precision, value reification, incomplete program specialization, strategies to exploit specialized program, incremental specialization, and data speci

  4. LOFS: Library of Online Streaming Feature Selection

    OpenAIRE

    Yu, Kui; Ding, Wei; Wu, Xindong

    2016-01-01

    As an emerging research direction, online streaming feature selection deals with sequentially added dimensions in a feature space while the number of data instances is fixed. Online streaming feature selection provides a new, complementary algorithmic methodology to enrich online feature selection, especially targets to high dimensionality in big data analytics. This paper introduces the first comprehensive open-source library for use in MATLAB that implements the state-of-the-art algorithms ...

  5. Music discovery methods using perceptual features

    OpenAIRE

    Nysäter, Richard

    2017-01-01

    Perceptual features are qualitative features used to describe music properties in relation to human perception instead of typical musical theory concepts such as pitches and chords. This report describes a music discovery platform which uses three different methods of music playlist generation to investigate if and how perceptual features work when used for music discovery. One method abstracts away the complexity of perceptual features and the other two lets users use them directly. Two user...

  6. New approach to spectral features modeling

    NARCIS (Netherlands)

    Brug, H. van; Scalia, P.S.

    2012-01-01

    The origin of spectral features, speckle effects, is explained, followed by a discussion on many aspects of spectral features generation. The next part gives an overview of means to limit the amplitude of the spectral features. This paper gives a discussion of all means to reduce the spectral

  7. MRI features associated with acute appendicitis

    NARCIS (Netherlands)

    Leeuwenburgh, Marjolein M. N.; Jensch, Sebastiaan; Gratama, Jan W. C.; Spilt, Aart; Wiarda, Bart M.; van Es, H. Wouter; Cobben, Lodewijk P. J.; Bossuyt, Patrick M. M.; Boermeester, Marja A.; Stoker, Jaap; Bouma, Wim H.; Houdijk, Alexander P. J.; Richir, Milan C.; Stockmann, Hein B. A. C.; Wiezer, Marinus J.; Verhagen, Thijs

    2014-01-01

    To identify MRI features associated with appendicitis. Features expected to be associated with appendicitis were recorded in consensus by two expert radiologists on 223 abdominal MRIs in patients with suspected appendicitis. Nine MRI features were studied: appendix diameter >7 mm, appendicolith,

  8. Featureous: an Integrated Approach to Location, Analysis and Modularization of Features in Java Applications

    DEFF Research Database (Denmark)

    Olszak, Andrzej

    of features in Java applications. Featureous addresses these concerns in four steps. Firstly, a dynamic method based on so-called feature-entry points is used to establish traceability links between features and their corresponding source code units. Secondly, this traceability forms a basis for a feature......-oriented analysis method that visualizes and measures features. Thirdly, scattering and tangling of features can be physically reduced using feature-oriented remodularization method that is based on multi-objective optimization of Java package structures. Finally, automated detection of so-called feature seed...... methods is proposed, to enable large-scale feature-oriented quality assessment. Featureous is implemented as a plugin to the NetBeans IDE. This implementation was used to evaluate the constituent methods of Featureous by applying them to several medium and large open-source Java systems. The gathered...

  9. A survey of object oriented languages in programming environments

    OpenAIRE

    Haakonsen, Harald

    1987-01-01

    Approved for public release; distribution is unlimited This thesis addresses object oriented programming languages; and a restrictive definition of object oriented programming languages is presented and defended. Differences between programming languages are discussed and related to interactive integrated programming environments. Topics related to user friendly interface to the computer system and modem programming practice are discussed. The thesis especially addresses features in ...

  10. SOME ENVIRONMENTAL FEATURES OF PHYTOPLANKTON

    Directory of Open Access Journals (Sweden)

    Taha A. Al-Tayyar

    2013-05-01

    Full Text Available Todefine the biological features of phytoplankton in Mosul  Dam  Lake, monthly samples were collectedalong a year from September 2003 to August 2004. Consisting thermalstratification and turn over periods from four locations in the main lake andanother location in the regulating lake. Total numbers of algae  reached 2300 cell/ml in the main lake and 1100cell/ml in the regulating lake.Bacillariophyta were dominant with a maximum number of 1400 cell/ml in autumn. Chlorophytawere dominant in autumn also with 550 cell/ml. Ten genus of Chlorophyta wereappeared in this water body: Cosmarium, Chlorella, Spirogyra, Scendesmus, Pediastrum, Tetraedron, Quadrigula, Ankiseradosm, Pandorina, and Straurastrum.Seven genus of Bacillariophyta were noticeable. Some genus of Cyanophyta was recorded as Aphanocapsa. In addition someEuglenophyta spp. were occurred in the main lake and the regulating lake also. On thebasis of these algae abundance, the lake is undergoing cultural Eutrophication.It has passed in mesotrophic state (the middle trophic state ofEutrophication. Some genera which were appeared are the indication ofeutrophic state.Totalplate count bacteria ranged from 400-1700 cell/ ml in the main lake and 200-950 cell/ml in the regulating lakewere also recorded. Coliform bacteria were founded with most probablenumber  reached 460 cell/100ml in themain lake and 150 cell/100ml in the regulating lake. Therefore, the lake wateris classified as moderate pure and considering a good source of raw water supplywith all treatment units and safe for swimming and recreational uses.

  11. New Features in ADS Labs

    Science.gov (United States)

    Accomazzi, Alberto; Kurtz, M. J.; Henneken, E. A.; Grant, C. S.; Thompson, D.; Di Milia, G.; Luker, J.; Murray, S. S.

    2013-01-01

    The NASA Astrophysics Data System (ADS) has been working hard on updating its services and interfaces to better support our community's research needs. ADS Labs is a new interface built on the old tried-and-true ADS Abstract Databases, so all of ADS's content is available through it. In this presentation we highlight the new features that have been developed in ADS Labs over the last year: new recommendations, metrics, a citation tool and enhanced fulltext search. ADS Labs has long been providing article-level recommendations based on keyword similarity, co-readership and co-citation analysis of its corpus. We have now introduced personal recommendations, which provide a list of articles to be considered based on a individual user's readership history. A new metrics interface provides a summary of the basic impact indicators for a list of records. These include the total and normalized number of papers, citations, reads, and downloads. Also included are some of the popular indices such as the h, g and i10 index. The citation helper tool allows one to submit a set of records and obtain a list of top 10 papers which cite and/or are cited by papers in the original list (but which are not in it). The process closely resembles the network approach of establishing "friends of friends" via an analysis of the citation network. The full-text search service now covers more than 2.5 million documents, including all the major astronomy journals, as well as physics journals published by Springer, Elsevier, the American Physical Society, the American Geophysical Union, and all of the arXiv eprints. The full-text search interface interface allows users and librarians to dig deep and find words or phrases in the body of the indexed articles. ADS Labs is available at http://adslabs.org

  12. Computer programs as accounting object

    Directory of Open Access Journals (Sweden)

    I.V. Perviy

    2015-03-01

    Full Text Available Existing approaches to the regulation of accounting software as one of the types of intangible assets have been considered. The features and current state of the legal protection of computer programs have been analyzed. The reasons for the need to use patent law as a means of legal protection of individual elements of computer programs have been discovered. The influence of the legal aspects of the use of computer programs for national legislation to their accounting reflection has been analyzed. The possible options for the transfer of rights from computer programs copyright owners have been analyzed that should be considered during creation of software accounting system at the enterprise. Identified and analyzed the characteristics of computer software as an intangible asset under the current law. General economic characteristics of computer programs as one of the types of intangible assets have been grounded. The main distinguishing features of software compared to other types of intellectual property have been all ocated

  13. Integrated elemental and Sr-Nd-Pb-Hf isotopic studies of Mesozoic mafic dykes from the eastern North China Craton: implications for the dramatic transformation of lithospheric mantle

    Science.gov (United States)

    Liu, Shen; Feng, Caixia; Santosh, M.; Feng, Guangying; Coulson, Ian M.; Xu, Mengjing; Guo, Zhuang; Guo, Xiaolei; Peng, Hao; Feng, Qiang

    2018-02-01

    Evolution of the lithospheric mantle beneath the North China Craton (NCC) from its Precambrian cratonic architecture until Paleozoic, and the transformation to an oceanic realm during Mesozoic, with implications on the destruction of cratonic root have attracted global attention. Here we present geochemical and isotopic data on a suite of newly identified Mesozoic mafic dyke swarms from the Longwangmiao, Weijiazhuang, Mengjiazhuang, Jiayou, Huangmi, and Xiahonghe areas (Qianhuai Block) along the eastern NCC with an attempt to gain further insights on the lithospheric evolution of the region. The Longwangmiao dykes are alkaline with LILE (Ba and K)- and LREE-enrichment ((La/Yb) N > 4.3) and EM1-like Sr-Nd-Pb-Hf isotopic signature ((87Sr/86Sr) i > 0.706; ε Nd (t) 16.6, (207Pb/204Pb) i > 15.4, (208Pb/204Pb) i > 36.8, ε Hf (t) 3.7), and display similar EM1-like isotopic features ((87Sr/86Sr) i > 0.706; ε Nd (t) 16.7, (207Pb/204Pb) i > 15.4, (208Pb/204Pb) i > 36.9, ε Hf (t) 2.4) and EM1-like isotopic features((87Sr/86Sr) i > 0.706; ε Nd (t) 16.7, (207Pb/204Pb) i > 15.4, (208Pb/204Pb) i > 36.9, ε Hf (t) 3.7) and EM1-like Sr-Nd-Pb-Hf isotopic features ((87Sr/86Sr) i > 0.706; ε Nd(t) 16.7, (207Pb/204Pb) i > 15.4, (208Pb/204Pb) i > 36.9, ε Hf (t) 9.3) and EM1-like isotopic composition ((87Sr/86Sr) i > 0.705; ε Nd (t) 16.9, (207Pb/204Pb) i > 15.5, (208Pb/204Pb) i > 36.9, ε Hf (t) Hf isotopic signature ((87Sr/86Sr) i > 0.705; ε Nd (t) 16.9, (207Pb/204Pb) i > 15.5, (208Pb/204Pb) i > 36.9, ε Hf (t) < -8.6). Our data from the various mafic dyke suites suggest that the magmas were derived from EM1-like lithospheric mantle, corresponding to lithospheric mantle modified by the previously foundered lower crust beneath the eastern NCC. Our results suggest contrasting lithospheric evolution from Triassic (212 Ma) to Cretaceous (123 Ma) beneath the NCC. These mafic dykes mark an important phase of lithospheric thinning in the eastern North China Craton.

  14. Qualified matching feature collection for feature point-based copy-move forgery detection

    Science.gov (United States)

    Yu, Liyang; Han, Qi; Niu, Xiamu

    2015-03-01

    The feature matching step plays a critical role during the copy-move forgery detection procedure. However, when several highly similar features simultaneously exist in the feature space, current feature matching methods will miss a considerable number of genuine matching feature pairs. To this end, we propose a clustering-based method to collect qualified matching features for the feature point-based methods. The proposed method can collect far more genuine matching features than existing methods do, and thus significantly improve the detection performance, especially for multiple pasting cases. Experimental results confirm the efficacy of the proposed method.

  15. Patch layout generation by detecting feature networks

    KAUST Repository

    Cao, Yuanhao

    2015-02-01

    The patch layout of 3D surfaces reveals the high-level geometric and topological structures. In this paper, we study the patch layout computation by detecting and enclosing feature loops on surfaces. We present a hybrid framework which combines several key ingredients, including feature detection, feature filtering, feature curve extension, patch subdivision and boundary smoothing. Our framework is able to compute patch layouts through concave features as previous approaches, but also able to generate nice layouts through smoothing regions. We demonstrate the effectiveness of our framework by comparing with the state-of-the-art methods.

  16. Feature coding for image representation and recognition

    CERN Document Server

    Huang, Yongzhen

    2015-01-01

    This brief presents a comprehensive introduction to feature coding, which serves as a key module for the typical object recognition pipeline. The text offers a rich blend of theory and practice while reflects the recent developments on feature coding, covering the following five aspects: (1) Review the state-of-the-art, analyzing the motivations and mathematical representations of various feature coding methods; (2) Explore how various feature coding algorithms evolve along years; (3) Summarize the main characteristics of typical feature coding algorithms and categorize them accordingly; (4) D

  17. Nearly maximally predictive features and their dimensions

    Science.gov (United States)

    Marzen, Sarah E.; Crutchfield, James P.

    2017-05-01

    Scientific explanation often requires inferring maximally predictive features from a given data set. Unfortunately, the collection of minimal maximally predictive features for most stochastic processes is uncountably infinite. In such cases, one compromises and instead seeks nearly maximally predictive features. Here, we derive upper bounds on the rates at which the number and the coding cost of nearly maximally predictive features scale with desired predictive power. The rates are determined by the fractal dimensions of a process' mixed-state distribution. These results, in turn, show how widely used finite-order Markov models can fail as predictors and that mixed-state predictive features can offer a substantial improvement.

  18. Clinical features of hepatitis D.

    Science.gov (United States)

    Farci, Patrizia; Niro, Grazia Anna

    2012-08-01

    Hepatitis D is caused by infection with hepatitis D virus (HDV), a defective RNA virus that requires the obligatory helper function of hepatitis B virus (HBV) for its in vivo transmission. Thus, HDV is acquired only by coinfection with HBV or by superinfection of an HBV carrier. The clinical outcome of hepatitis D differs according to the modality of infection. Whereas coinfection evolves to chronicity in only 2% of the cases, superinfection results in chronic infection in over 90% of the cases. HDV is a highly pathogenic virus that causes acute, often fulminant hepatitis, as well as a rapidly progressive form of chronic viral hepatitis, leading to cirrhosis in 70 to 80% of the cases. The clinical picture of HDV disease is evolving as a consequence of a significant change in the epidemiology of HDV infection, which has led to a significant decline in incidence in Western countries, mainly as a result of universal HBV vaccination programs. However, in the face of a declining prevalence in areas of old endemicity like Europe, immigration poses a threat of HDV resurgence. The interaction of HDV with other hepatitis viruses or human immunodeficiency virus is complex and may lead to different patterns in terms of virologic expression and immunologic responses. Multiple viral infections are associated with rapid progression of liver fibrosis and eventually with the development of hepatocellular carcinoma. Hepatitis D is not a vanishing disease, and continuous efforts should be made to improve its prevention and treatment. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

  19. Computed tomographic features of afferent loop syndrome: pictorial essay

    Energy Technology Data Exchange (ETDEWEB)

    Zissin, R. [Tel-Aviv Univ., Dept. of Diagnostic Imaging, Sapir Medical Center, Kfar Saba, Sackler Faculty of Medicine, Tel Aviv (Israel); Hertz, M. [Tel-Aviv Univ., Dept. of Diagnostic Imaging, Chaim Sheba Medical Center, Tel Hashomer, Tel Aviv (Israel); Paran, H. [Tel-Aviv Univ., Dept. of Diagnostic Imaging, Surgery ' A' , Sapir Medical Center, Kfar Saba, Sackler Faculty of Medicine, Tel Aviv (Israel); Osadchy, A. [Tel-Aviv Univ., Dept. of Diagnostic Imaging, Sapir Medical Center, Kfar Saba, Sackler Faculty of Medicine, Tel Aviv (Israel); Gayer, G. [Tel-Aviv Univ., Dept. of Diagnostic Imaging, Assaf Harofe Medical Center, Zrifin, Sackler Faculty of Medicine, Tel Aviv (Israel)

    2005-04-15

    This pictorial essay reviews the computed tomography (CT) findings of afferent loop syndrome (ALS) in various pathological conditions to demonstrate the contribution of a common imaging modality-that is, abdominal CT, used nowadays for various abdominal complaints-to the diagnosis of ALS. ALS is caused by obstruction of the duodenum and jejunum proximal to a gastrojejunostomy anastomosis. It is a rare complication after Billroth II subtotal gastrectomy and even more rare after total or subtotal gastrectomy with Roux-en-Y reconstruction. Although currently advanced medical treatment and endoscopic interventions have dramatically decreased the necessity of surgery for peptic ulcer disease, ALS may appear years after previously common operations. Alternatively, the use of surgical resection for early gastric cancer nowadays leads to an increasing rate of malignancy-related ALS. Clinically, ALS may be difficult to diagnose as its presentation may be vague and nonspecific, but it has a characteristic appearance on CT. Clinicians and radiologists should therefore be familiar with this rare complication. Prompt recognition and correct diagnosis of this syndrome and its probable etiology are important as a guide for treatment. This review illustrates the CT features of ALS in various conditions. (author)

  20. Providing Appropriate Exploratory Programs for Students in the Middle Grades.

    Science.gov (United States)

    Barnhart, Edward A.

    1987-01-01

    Describes a middle school program in Washington State that offers 20-day activity minicourses (ranging from aerobic dancing to weightlifting) and seven-week "unified arts" courses (computer lab, wood shop, cooking, art, and dramatics) designed to help emerging adolescents explore various vocational and avocational interests. Includes six…

  1. Advancing Teacher Education and Curriculum Development through Study Abroad Programs

    Science.gov (United States)

    Rhodes, Joan A., Ed.; Milby, Tammy M., Ed.

    2016-01-01

    The number of English language students in American schools has dramatically increased in recent years, creating a greater awareness of cross-cultural issues and considerations in education. Globalization as well as an increase in international exchange student programs has proven that pre-service teachers can benefit from traveling abroad and…

  2. Evaluation of textural features for multispectral images

    Science.gov (United States)

    Bayram, Ulya; Can, Gulcan; Duzgun, Sebnem; Yalabik, Nese

    2011-11-01

    Remote sensing is a field that has wide use, leading to the fact that it has a great importance. Therefore performance of selected features plays a great role. In order to gain some perspective on useful textural features, we have brought together state-of-art textural features in recent literature, yet to be applied in remote sensing field, as well as presenting a comparison with traditional ones. Therefore we selected most commonly used textural features in remote sensing that are grey-level co-occurrence matrix (GLCM) and Gabor features. Other selected features are local binary patterns (LBP), edge orientation features extracted after applying steerable filter, and histogram of oriented gradients (HOG) features. Color histogram feature is also used and compared. Since most of these features are histogram-based, we have compared performance of bin-by-bin comparison with a histogram comparison method named as diffusion distance method. During obtaining performance of each feature, k-nearest neighbor classification method (k-NN) is applied.

  3. Abdominal tuberculous lymphadenopathy: MRI features

    Energy Technology Data Exchange (ETDEWEB)

    Backer, A.I. De [General Hospital Sint-Lucas, Department of Radiology, Ghent (Belgium); Mortele, K.J. [Brigham and Women' s Hospital, Harvard Medical School, Department of Radiology, Division of Abdominal Imaging and Intervention, Boston, MA (United States); Deeren, D. [Ziekenhuisnetwerk Antwerpen, Department of Internal Medicine, Campus Stuivenberg, Antwerp (Belgium); Catholic University of Leuven, Department of Internal Medicine, University Hospitals, Leuven (Belgium); Vanschoubroeck, I.J. [Ziekenhuisnetwerk Antwerpen, Department of Internal Medicine, Campus Stuivenberg, Antwerp (Belgium); Keulenaer, B.L. De [Royal Darwin Hospital, Intensive Care Unit, Tiwi, NT (Australia)

    2005-10-01

    The aim of this study was to describe the MRI features of abdominal tuberculous lymphadenopathy. MRI studies of 13 patients with abdominal tuberculous lymphadenopathy were reviewed with regard to anatomic distribution and size. Signal intensities, in relation to abdominal wall muscle, on unenhanced T1- and T2-weighted images and patterns of contrast enhancement of lymphadenopathy were evaluated in each patient. In each patient, the largest lymph node with the same imaging characteristic was evaluated. The upper paraaortic region was the most common site of involvement (n=12 patients), followed by the lesser omentum (n=10 patients), the anterior pararenal space (n=9 patients), the lower paraaortic area (n=8 patients), the small bowel mesentery (n=6 patients), the greater omentum (n=2 patients) and the originating site of the inferior mesenteric artery (n=2 patients). The mean lymph node size was 1.8 cm (range 0.5-5 cm). The overall mean lymph node number per patient was 16 (range 2-50). A total of 41 lymph nodes were evaluated in 13 patients. On T2-weighted images, 40 lesions were hyperintense and one lesion was isointense. Nine hyperintense lesions showed a hypointense peripheral rim and seven internal heterogeneity. Perinodal T2-hyperintensity was present in 23 lesions. The latter finding was valid for all patients. On T1-weighted images, 30 lesions were hypointense and 11 isointense. Nine hypointense lesions demonstrated a hyperintense peripheral rim, and six were heterogeneous. Contrast-enhanced fat-suppressed T1-weighted images demonstrated predominant peripheral enhancement in 28 lesions: (1) peripheral uniform, thin (n=19); (2) thick irregular, complete (n=3); and (3) conglomerate group of nodes showing peripheral and central areas of rim enhancement (n=6). Heterogeneous and homogeneous enhancement was present in ten and three lesions, respectively. Combinations of enhancing patterns in the same nodal group and different nodal groups were seen in eight and

  4. Sleep Stage Classification Using Unsupervised Feature Learning

    Directory of Open Access Journals (Sweden)

    Martin Längkvist

    2012-01-01

    Full Text Available Most attempts at training computers for the difficult and time-consuming task of sleep stage classification involve a feature extraction step. Due to the complexity of multimodal sleep data, the size of the feature space can grow to the extent that it is also necessary to include a feature selection step. In this paper, we propose the use of an unsupervised feature learning architecture called deep belief nets (DBNs and show how to apply it to sleep data in order to eliminate the use of handmade features. Using a postprocessing step of hidden Markov model (HMM to accurately capture sleep stage switching, we compare our results to a feature-based approach. A study of anomaly detection with the application to home environment data collection is also presented. The results using raw data with a deep architecture, such as the DBN, were comparable to a feature-based approach when validated on clinical datasets.

  5. Clafer: Unifying Class and Feature Modeling

    DEFF Research Database (Denmark)

    Bąk, Kacper; Diskin, Zinovy; Antkiewicz, Michal

    2015-01-01

    We present Clafer (class, feature, reference), a class modeling language with first-class support for feature modeling. We designed Clafer as a concise notation for meta-models, feature models, mixtures of meta- and feature models (such as components with options), and models that couple feature...... models and meta-models via constraints (such as mapping feature configurations to component configurations or model templates). Clafer allows arranging models into multiple specialization and extension layers via constraints and inheritance. We identify several key mechanisms allowing a meta......-modeling language to express feature models concisely. Clafer unifies basic modeling constructs, such as class, association, and property, into a single construct, called clafer. We provide the language with a formal semantics built in a structurally explicit way. The resulting semantics explains the meaning...

  6. Legal features of the drug advertising.

    Science.gov (United States)

    Pashkov, Vitalii M; Olefir, Andrii A; Bytyak, Oleksiy Y

    ; - Prohibit the advertising of medicines for children, as well as drugs for the treatment of infectious, parasitic diseases and pathogens of these diseases, chronic insomnia, cardiovascular diseases, and those costs are reimbursed by government programs or trade names may lead to mix with prescription drugs; - Adopt ethical standards (codes) promotion of drugs for pharmaceutical companies; - Advertising to the public shall not contain any reference to cost or pricing features for medicines.

  7. Retinal Identification Based on an Improved Circular Gabor Filter and Scale Invariant Feature Transform

    Directory of Open Access Journals (Sweden)

    Xiaoming Xi

    2013-07-01

    Full Text Available Retinal identification based on retinal vasculatures in the retina provides the most secure and accurate means of authentication among biometrics and has primarily been used in combination with access control systems at high security facilities. Recently, there has been much interest in retina identification. As digital retina images always suffer from deformations, the Scale Invariant Feature Transform (SIFT, which is known for its distinctiveness and invariance for scale and rotation, has been introduced to retinal based identification. However, some shortcomings like the difficulty of feature extraction and mismatching exist in SIFT-based identification. To solve these problems, a novel preprocessing method based on the Improved Circular Gabor Transform (ICGF is proposed. After further processing by the iterated spatial anisotropic smooth method, the number of uninformative SIFT keypoints is decreased dramatically. Tested on the VARIA and eight simulated retina databases combining rotation and scaling, the developed method presents promising results and shows robustness to rotations and scale changes.

  8. La dramatización radiofónica de contenidos educativos: Una experiencia universitaria The Radio Dramatization of Educational Contents: A Higher Education Experience

    Directory of Open Access Journals (Sweden)

    Jordi Xifra Triadú

    2010-10-01

    , focusing on its teaching and entertaining function rather than its informative one. The UOC has started the first journalism based learning projects so as to provide its students with new learning contents through its radio dramatization. The application of the method developed by journalism to life-long learning reveals the radio as a key element, since it enables to keep the requirement of flexibility (in space, time and of appliance. In other words: mobility and portability. This article explains the foundations of journalism based learning and shows the results and conclusions of the first results of its application to online university teaching, among which the positive reception by students, thanks in particular to its entertainment function, and its contribution to facilitate the study of the educational contents.

  9. Decision-Tree Program

    Science.gov (United States)

    Buntine, Wray

    1994-01-01

    IND computer program introduces Bayesian and Markov/maximum-likelihood (MML) methods and more-sophisticated methods of searching in growing trees. Produces more-accurate class-probability estimates important in applications like diagnosis. Provides range of features and styles with convenience for casual user, fine-tuning for advanced user or for those interested in research. Consists of four basic kinds of routines: data-manipulation, tree-generation, tree-testing, and tree-display. Written in C language.

  10. Learning Cython programming

    CERN Document Server

    Herron, Philip

    2013-01-01

    A practical and a fast-paced guide that gives you all the information you need to start programming using Cython.This book is for developers who love C/C++ for low latency and speed but who also require the ability to add more dynamic features to applications both fast and reliably. It will also show you how you can get new applications off the ground by reusing Python libraries to get started.

  11. San Mateo County's Server Information Program (S.I.P.): A Community-Based Alcohol Server Training Program.

    Science.gov (United States)

    de Miranda, John

    The field of alcohol server awareness and training has grown dramatically in the past several years and the idea of training servers to reduce alcohol problems has become a central fixture in the current alcohol policy debate. The San Mateo County, California Server Information Program (SIP) is a community-based prevention strategy designed to…

  12. PyEEG: an open source Python module for EEG/MEG feature extraction.

    Science.gov (United States)

    Bao, Forrest Sheng; Liu, Xin; Zhang, Christina

    2011-01-01

    Computer-aided diagnosis of neural diseases from EEG signals (or other physiological signals that can be treated as time series, e.g., MEG) is an emerging field that has gained much attention in past years. Extracting features is a key component in the analysis of EEG signals. In our previous works, we have implemented many EEG feature extraction functions in the Python programming language. As Python is gaining more ground in scientific computing, an open source Python module for extracting EEG features has the potential to save much time for computational neuroscientists. In this paper, we introduce PyEEG, an open source Python module for EEG feature extraction.

  13. Feature Detection Systems Enhance Satellite Imagery

    Science.gov (United States)

    2009-01-01

    -resolution satellites, which provide the benefit of images detailed enough to reveal large features like highways while still broad enough for global coverage, continue to scan the entirety of the Earth s surface. In 2012, NASA plans to launch the Landsat Data Continuity Mission (LDCM), or Landsat 8, to extend the Landsat program s contributions to cartography, water management, natural disaster relief planning, and more.

  14. Population dynamics in Nepal: features and issues.

    Science.gov (United States)

    Bajracharya, P

    1997-07-01

    This article features a discussion of Nepal's population dynamics and several major demographic issues for the future. The fertility rate in Nepal has declined, but insufficiently. There is a need to increase the contraceptive prevalence rate (CPR) from 29% to 40% over the next decade. CPR may be increased by improving functional literacy, increasing the length of schooling, awareness creation among subgroups, and improvement in the socioeconomic status of the population. Nepal has uncontrolled migration. There is a need to define appropriate international and internal migration policies and to improve regional development. There is also the need for nutrition programs targeted to malnourished children and pregnant mothers. Nepal is a country with a high birthrate of 37.5/1000, a declining death rate of 13.8/1000, high infant mortality of 97.5/1000 live births, high child mortality of 165/1000, and high total fertility of 5.5 children/woman. 42.7% of population are aged under 15 years. In 1991, the population growth rate was the highest in the terai region at 2.8%. Migration has increased population in the terai. The share of population in the hill and mountain regions has increased. The sex ratio of population was favorable to females in 1991. The sex ratio among persons aged 0-14 years and among those aged 45-60 and over favored males. The young and old populations continue to grow. The mean age of population was 18.8 years in 1991. The share of urban population was about 9.2% in 1991, but it is growing. Migration pressure arises at the destination due to social and political conflict, population pressure, land issues, and lack of social services.

  15. A guide to highly effective quality programs.

    Science.gov (United States)

    Byrnes, John; Fifer, Joe

    2010-01-01

    To dramatically improve quality while decreasing costs, hospitals should: ensure all executives are vocal and visible supporters of quality improvement; focus the board of directors on quality as a strategic priority; strategically target quality resources to improve care for the majority of patients; use the finance system as the foundation for automated quality reporting; form a strong alliance between the CFO and chief quality officer, with each playing a leadership role in the quality program; rely on a well-executed quality program to improve efficiency and decrease the cost of care.

  16. The Impact on Future Guidance Programs of Current Developments in Computer Science, Telecommunications, and Biotechnology.

    Science.gov (United States)

    Mitchell, Lynda K.; Hardy, Philippe L.

    The purpose of this chapter is to envision how the era of technological revolution will affect the guidance, counseling, and student support programs of the future. Advances in computer science, telecommunications, and biotechnology are discussed. These advances have the potential to affect dramatically the services of guidance programs of the…

  17. Loss of the interferon-γ-inducible regulatory immunity-related GTPase (IRG), Irgm1, causes activation of effector IRG proteins on lysosomes, damaging lysosomal function and predicting the dramatic susceptibility of Irgm1-deficient mice to infection

    NARCIS (Netherlands)

    Maric-Biresev, Jelena; Hunn, Julia P; Krut, Oleg; Helms, J Bernd; Martens, Sascha; Howard, Jonathan C

    2016-01-01

    BACKGROUND: The interferon-γ (IFN-γ)-inducible immunity-related GTPase (IRG), Irgm1, plays an essential role in restraining activation of the IRG pathogen resistance system. However, the loss of Irgm1 in mice also causes a dramatic but unexplained susceptibility phenotype upon infection with a

  18. Performance Comparison of Feature Selection Methods

    Directory of Open Access Journals (Sweden)

    Phyu Thu Zar

    2016-01-01

    Full Text Available Feature Subset Selection is an essential pre-processing task in Data Mining. Feature selection process refers to choosing subset of attributes from the set of original attributes. This technique attempts to identify and remove as much irrelevant and redundant information as possible. In this paper, a new feature subset selection algorithm based on conditional mutual information approach is proposed to select the effective feature subset. The effectiveness of the proposed algorithm is evaluated by comparing with the other well-known existing feature selection algorithms using standard datasets from UC Iravine and WEKA (Waikato Environment for Knowledge Analysis. The performance of the proposed algorithm is evaluated by multi-criteria that take into account not only the classification accuracy but also number of selected features.

  19. Effective Feature Preprocessing for Time Series Forecasting

    DEFF Research Database (Denmark)

    Zhao, Junhua; Dong, Zhaoyang; Xu, Zhao

    2006-01-01

    Time series forecasting is an important area in data mining research. Feature preprocessing techniques have significant influence on forecasting accuracy, therefore are essential in a forecasting model. Although several feature preprocessing techniques have been applied in time series forecasting......, there is so far no systematic research to study and compare their performance. How to select effective techniques of feature preprocessing in a forecasting model remains a problem. In this paper, the authors conduct a comprehensive study of existing feature preprocessing techniques to evaluate their empirical...... performance in time series forecasting. It is demonstrated in our experiment that, effective feature preprocessing can significantly enhance forecasting accuracy. This research can be a useful guidance for researchers on effectively selecting feature preprocessing techniques and integrating them with time...

  20. Self-Weighted Supervised Discriminative Feature Selection.

    Science.gov (United States)

    Zhang, Rui; Nie, Feiping; Li, Xuelong

    2017-09-07

    In this brief, a novel self-weighted orthogonal linear discriminant analysis (SOLDA) problem is proposed, and a self-weighted supervised discriminative feature selection (SSD-FS) method is derived by introducing sparsity-inducing regularization to the proposed SOLDA problem. By using the row-sparse projection, the proposed SSD-FS method is superior to multiple sparse feature selection approaches, which can overly suppress the nonzero rows such that the associated features are insufficient for selection. More specifically, the orthogonal constraint ensures the minimal number of selectable features for the proposed SSD-FS method. In addition, the proposed feature selection method is able to harness the discriminant power such that the discriminative features are selected. Consequently, the effectiveness of the proposed SSD-FS method is validated theoretically and experimentally.