WorldWideScience

Sample records for program etv ccep

  1. ENVIRONMENTAL TECHNOLOGY VERIFICATION COATINGS AND COATING EQUIPMENT PROGRAM (ETV CCEP), FINAL TECHNOLOGY APPLICATIONS GROUP TAGNITE--TESTING AND QUALITY ASSURANCE PLAN (T/QAP)

    Science.gov (United States)

    The overall objective of the Environmental Testing and Verification Coatings and Coating Equipment Program is to verify pollution prevention and performance characteristics of coating technologies and make the results of the testing available to prospective coating technology use...

  2. ENVIRONMENTAL TECHNOLOGY VERIFICATION (ETV) PROGRAM: FUEL CELLS

    Science.gov (United States)

    The U.S. Environmental Protection Agency (EPA) Environmental Technology Verification (ETV) Program evaluates the performance of innovative air, water, pollution prevention and monitoring technologies that have the potential to improve human health and the environment. This techno...

  3. ENVIRONMENTAL TECHNOLOGY VERIFICATION (ETV) PROGRAM; BAGHOUSE FILTRATION PRODUCTS

    Science.gov (United States)

    The U.S. Environmental Protection Agency (EPA) Environmental Technology Verification (ETV) Program evaluates the performance of innovative air, water, pollution prevention and monitoring technologies that have the potential to improve human health and the environment. This techno...

  4. ETV - HOMELAND SECURITY EVALUATION OF CYANIDE DETECTORS

    Science.gov (United States)

    EPA's Environmental Technology Verification (ETV) Program was established in 1995 to objectively verify the performance of technologies that measure / monitor the quality of our environment, both for background or at suspected contamination site. The ETV program has established...

  5. Tantsufilm "Teine" ETV-s

    Index Scriptorium Estoniae

    2005-01-01

    Täna on ETV-s rahvusvahelises ühistöös valminud tantsufilm "Teine" ("Another") : režissöör Rene Vilbre : stsenaristid Rene Vilbre, Teet Kask, Helena Jonsdottir : produtsent Heidi Pruuli : koreograaf ja peaoaline Helena Jonsdottir : osatäitjad Mait Malmsten, Ruslan Stepanov. Filmi võtted toimusid Tartu vanglas

  6. ETV REPORT AND STATEMENT, ABB INC. BIOTEMP VETABLE OIL - BASED INSULATING DIELECTRIC FLUID

    Science.gov (United States)

    THE USEPA has created the ETV program to facilitate the deployment of innovative of improved environmental technologies through performance verification and information dissemination. The goal of the ETV Program is to further environmental protection by substantially acceleratin...

  7. ETV Program Report: Coatings for Wastewater Collection Systems - Protective Liner Systems, Inc., Epoxy Mastic, PLS-614

    Science.gov (United States)

    The Protective Liner Systems International, Inc. Epoxy Mastic PLS-614 coating used for wastewater collection system rehabilitation was evaluated by EPA’s Environmental Technology Verification Program under laboratory conditions at the Center for Innovative Grouting Material and T...

  8. ETV Program Report: Coatings for Wastewater Collection Systems - Standard Cement Materials, Epoxy Coating 4553

    Science.gov (United States)

    The Standard Cement Materials, Inc. Standard Epoxy Coating 4553™ (SEC 4553) epoxy coating used for wastewater collection system rehabilitation was evaluated by EPA’s Environmental Technology Verification Program under laboratory conditions at the Center for Innovative Grouting Ma...

  9. ETV VERTIFICATION REPORT AND VERIFICATION STATEMENT: COOPER POWER SYSTEMS ENVIROTEMP® FR3™ VEGETABLE OIL-BASED INSULATING DIELECTRIC FLUID

    Science.gov (United States)

    EPA's ETV Program, through the NRMRL has partnered with the California Department of Toxic Substances Control (DTSC) under an ETV Pilot Project to verify pollution prevention, recycling, and waste treatment technologies. This report and statement provides documentation of perfor...

  10. ENVIRONMENTAL TECHNOLOGY VERIFICATION (ETV) OF PAINT OVERSPRAY ARRESTORS

    Science.gov (United States)

    The paper discusses the environmental technology verification (ETV) of paint overspray arrestors undertaken as part of a program to accelerate the development and commercialization of improved environmental technologies through third-party verififcation and reporting of performan...

  11. ETV teeb Tartu vanglas tantsufilmi

    Index Scriptorium Estoniae

    2005-01-01

    ETV-l valmib koos EFS-i ja Estinfilmiga kultuurikanali ARTE tellimusel tantsufilm "Teine" : režissöör Rene Vilbre : stsenarist Teet Kask : produtsent Heidi Pruuli : koreograaf ja peaoaline Helena Jonsdottir

  12. Novel 5′ Fusion Partners of ETV1 and ETV4 in Prostate Cancer

    Directory of Open Access Journals (Sweden)

    Joao D. Barros-Silva

    2013-07-01

    Full Text Available Gene fusions involving the erythroblast transformation-specific (ETS transcription factors ERG, ETV1, ETV4, ETV5, and FLI1 are a common feature of prostate carcinomas (PCas. Themost common upstream fusion partner described is the androgenregulated prostate-specific gene TMPRSS2, most frequently with ERG, but additional 5′fusion partners have been described. We performed 5′ rapid amplification of cDNA ends in 18 PCas with ETV1, ETV4, or ETV5 outlier expression to identify the 5′ fusion partners. We also evaluated the exon-level expression profile of these ETS genes in 14 cases. We identified and confirmed by fluorescent in situ hybridization (FISH and reverse transcription-polymerase chain reaction the two novel chimeric genes OR51E2-ETV1 and UBTF-ETV4 in two PCas. OR51E2 encodes a G-protein.coupled receptor that is overexpressed in PCas, whereas UBTF is a ubiquitously expressed gene encoding an HMG-box DNA-binding protein involved in ribosome biogenesis. We additionally describe two novel gene fusion combinations of previously described genes, namely, SLC45A3- ETV4 and HERVK17-ETV4. Finally, we found one PCa with TMPRSS2-ETV1, one with C15orf21-ETV1, one with EST14-ETV1, and two with 14q133-q21.1-ETV1. In nine PCas (eight ETV1 and one ETV5, exhibiting ETS outlier expression and genomic rearrangement detected by FISH, no 5′ fusion partner was found. Our findings contribute significantly to characterize the heterogeneous group of ETS gene fusions and indicate that all genes described as 5′ fusion partners with one ETS gene can most likely be rearranged with any of the other ETS genes involved in prostate carcinogenesis.

  13. Novel 5' fusion partners of ETV1 and ETV4 in prostate cancer.

    Science.gov (United States)

    Barros-Silva, João D; Paulo, Paula; Bakken, Anne Cathrine; Cerveira, Nuno; Løvf, Marthe; Henrique, Rui; Jerónimo, Carmen; Lothe, Ragnhild A; Skotheim, Rolf Inge; Teixeira, Manuel R

    2013-07-01

    Gene fusions involving the erythroblast transformation-specific (ETS) transcription factors ERG, ETV1, ETV4, ETV5, and FLI1 are a common feature of prostate carcinomas (PCas). The most common upstream fusion partner described is the androgen-regulated prostate-specific gene TMPRSS2, most frequently with ERG, but additional 5' fusion partners have been described. We performed 5' rapid amplification of cDNA ends in 18 PCas with ETV1, ETV4, or ETV5 outlier expression to identify the 5' fusion partners. We also evaluated the exon-level expression profile of these ETS genes in 14 cases. We identified and confirmed by fluorescent in situ hybridization (FISH) and reverse transcription-polymerase chain reaction the two novel chimeric genes OR51E2-ETV1 and UBTF-ETV4 in two PCas. OR51E2 encodes a G-protein-coupled receptor that is overexpressed in PCas, whereas UBTF is a ubiquitously expressed gene encoding an HMG-box DNA-binding protein involved in ribosome biogenesis. We additionally describe two novel gene fusion combinations of previously described genes, namely, SLC45A3-ETV4 and HERVK17-ETV4. Finally, we found one PCa with TMPRSS2-ETV1, one with C15orf21-ETV1, one with EST14-ETV1, and two with 14q133-q21.1-ETV1. In nine PCas (eight ETV1 and one ETV5), exhibiting ETS outlier expression and genomic rearrangement detected by FISH, no 5' fusion partner was found. Our findings contribute significantly to characterize the heterogeneous group of ETS gene fusions and indicate that all genes described as 5' fusion partners with one ETS gene can most likely be rearranged with any of the other ETS genes involved in prostate carcinogenesis.

  14. ETV kutsub tantsule / Tiit Tuumalu

    Index Scriptorium Estoniae

    Tuumalu, Tiit, 1971-

    2003-01-01

    Tantsufilmide õhtu "Meeste mängud" ETVs. Lähemalt filmidest "The Car Man" (koreograaf Matthew Bourne, režissöör Ross MacGibbon), "Achilleuse tulek" ("Enter Achilleus" : koreograaf Lloyd Newson, režissöör Clara van Gool), "Ühevärvilised inimesed, elutud unistused" ("Dead Dreams of Monochrome Men" : koreograaf Lloyd Newson, režissöör David Hinton). Lisatud filmide kava

  15. AFSC/NMML/CCEP: Channel Islands Pinniped Census

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The National Marine Mammal Laboratories' California Current Ecosystem Program (AFSC/NOAA) initiated and maintains census programs for California sea lions (Zalophus...

  16. Analysis list: Etv2 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Etv2 Pluripotent stem cell + mm9 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/target/Etv...2.1.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/target/Etv2.5.tsv http://dbarchive.bioscienced...bc.jp/kyushu-u/mm9/target/Etv2.10.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/colo/Etv2.Pluripotent_s

  17. Comunidad del conocimiento Ecosalud Etv

    Directory of Open Access Journals (Sweden)

    Laura Magaña Valladares

    2013-01-01

    Full Text Available El Proyecto Liderazgo en Ecosalud para las Enfermedades Transmitidas por Vectores (ETV en América Latina y el Caribe colocó entre los principales objetivos de trabajo la conformación de una comunidad del conocimiento que garantizara la sostenibilidad de la estrategia de capacitación. Este artículo es el resultado de una investigación documental centrada en la construcción de una comunidad del conocimiento desde el Portal de la iniciativa, aprovechando las bondades del trabajo colaborativo que brinda la perspectiva de la web 2.0 y colocando a las tecnologías de la información y las comunicaciones como un agente clave al servicio de la salud pública en la región.

  18. Minister proposes re-introducing ETV commercials / Kairi Kurm

    Index Scriptorium Estoniae

    Kurm, Kairi

    2005-01-01

    Kultuuriminister Raivo Palmaru tegi ettepaneku hakata ETV-s taas reklaami näitama, millest saadud tuludega suurendada telekanali eelarvet. Kanal 2 ja TV3 juhtide arvates mõjutaks see meediaturu stabiilsust ning oleks ebaaus konkurents

  19. The Use of ETV. A Handbook for Students and Teachers.

    Science.gov (United States)

    Gibson, Tony

    Educational television (ETV) has become a multi-purpose tool--more flexible, more accessible, less costly than ever before. This book discusses the kind of "eye to eye" rapport and communication which is possible through ETV. The growth and functions today of ETV in the learning situation are reviewed. Solutions and innovations are examined which…

  20. Analysis list: Etv6 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Etv6 Blood + mm9 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/target/Etv6.1.tsv h...ttp://dbarchive.biosciencedbc.jp/kyushu-u/mm9/target/Etv6.5.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/target/Etv...6.10.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/colo/Etv6.Blood.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/colo/Blood.gml ...

  1. Failure of ETV in patients with the highest ETV success scores.

    Science.gov (United States)

    Gianaris, Thomas J; Nazar, Ryan; Middlebrook, Emily; Gonda, David D; Jea, Andrew; Fulkerson, Daniel H

    2017-09-01

    OBJECTIVE Endoscopic third ventriculostomy (ETV) is a surgical alternative to placing a CSF shunt in certain patients with hydrocephalus. The ETV Success Score (ETVSS) is a reliable, simple method to estimate the success of the procedure by 6 months of postoperative follow-up. The highest score is 90, estimating a 90% chance of the ETV effectively treating hydrocephalus without requiring a shunt. Treatment with ETV fails in certain patients, despite their being the theoretically best candidates for the procedure. In this study the authors attempted to identify factors that further predicted success in patients with the highest ETVSSs. METHODS A retrospective review was performed of all patients treated with ETV at 3 institutions. Demographic, radiological, and clinical data were recorded. All patients by definition were older than 1 year, had obstructive hydrocephalus, and did not have a prior shunt. Failure of ETV was defined as the need for a shunt by 1 year. The ETV was considered a success if the patient did not require another surgery (either shunt placement or a repeat endoscopic procedure) by 1 year. A statistical analysis was performed to identify factors associated with success or failure. RESULTS Fifty-nine patients met the entry criteria for the study. Eleven patients (18.6%) required further surgery by 1 year. All of these patients received a shunt. The presenting symptom of lethargy statistically correlated with success (p = 0.0126, odds ratio [OR] = 0.072). The preoperative radiological finding of transependymal flow (p = 0.0375, OR 0.158) correlated with success. A postoperative larger maximum width of the third ventricle correlated with failure (p = 0.0265). CONCLUSIONS The preoperative findings of lethargy and transependymal flow statistically correlated with success. This suggests that the best candidates for ETV are those with a relatively acute elevation of intracranial pressure. Cases without these findings may represent the failures in this

  2. ETVs näeb uusi dokfilme

    Index Scriptorium Estoniae

    2006-01-01

    ETVs täna kolm noore autori 2005.a. valminud dokumentaalfilmi : Kullar Viimse "Jumalaga", Kristin Raubi "O.M.V.K." ja Riin Kranna ja shveitslase Enrico Pizzolato "Vaimu võsuke". Viimase filmi meeskond koosneb India filmitudengitest, tegevus toimub Indias

  3. ETV katuse all keedeti salaseepi / Tiina Jõgeda

    Index Scriptorium Estoniae

    Jõgeda, Tiina, 1962-

    2011-01-01

    Rahvusringhäälingu (ERR) tootmisteenistuse juhataja Janno-Hans Arro, kes seoses pettustega vallandati augustis ERR-ist, valmistas mitu aastat ette suurejoonelist kodumaist teleseriaali. Seriaali filmiti sel suvel Madeiral. Põhjendustest, miks ETV seda ära osta ei taha

  4. Novel RNA hybridization method for the in situ detection of ETV1, ETV4 and ETV5 gene fusions in prostate cancer

    Science.gov (United States)

    Kunju, Lakshmi Priya; Carskadon, Shannon; Siddiqui, Javed; Tomlins, Scott A; Chinnaiyan, Arul M; Palanisamy, Nallasivam

    2014-01-01

    The genetic basis of 50–60% of prostate cancer is attributable to rearrangements in ETS (ERG, ETV1, ETV4, and ETV5), BRAF and RAF1 genes and overexpression of SPINK1. The development and validation of reliable detection methods are warranted to classify various molecular subtypes of prostate cancer for diagnostic and prognostic purposes. ETS gene rearrangements are typically detected by fluorescence in situ hybridization (FISH) and reverse transcription PCR methods. Recently, monoclonal antibodies against ERG have been developed that detect the truncated ERG protein in immunohistochemical assays where staining levels are strongly correlated with ERG rearrangement status by FISH. However, specific antibodies for ETV1, ETV4 and ETV5 are unavailable, challenging their clinical use. We developed a novel RNA in situ hybridization based assay for the in situ detection of ETV1, ETV4, and ETV5 in formalin fixed paraffin embedded tissues from prostate needle biopsies, prostatectomy, and metastatic prostate cancer specimens using RNA probes. Further, with combined RNA in situ hybridization and immunohistochemistry we identified a rare subset of prostate cancer with dual ETS gene rearrangements in collisions of independent tumor foci. The high specificity and sensitivity of RNA in situ hybridization provides an alternate method enabling bright field in situ detection of ETS gene aberrations in routine clinically available prostate cancer specimens. PMID:25203299

  5. Novel RNA hybridization method for the in situ detection of ETV1, ETV4, and ETV5 gene fusions in prostate cancer.

    Science.gov (United States)

    Kunju, Lakshmi P; Carskadon, Shannon; Siddiqui, Javed; Tomlins, Scott A; Chinnaiyan, Arul M; Palanisamy, Nallasivam

    2014-09-01

    The genetic basis of 50% to 60% of prostate cancer (PCa) is attributable to rearrangements in E26 transformation-specific (ETS) (ERG, ETV1, ETV4, and ETV5), BRAF, and RAF1 genes and overexpression of SPINK1. The development and validation of reliable detection methods are warranted to classify various molecular subtypes of PCa for diagnostic and prognostic purposes. ETS gene rearrangements are typically detected by fluorescence in situ hybridization and reverse-transcription polymerase chain reaction methods. Recently, monoclonal antibodies against ERG have been developed that detect the truncated ERG protein in immunohistochemical assays where staining levels are strongly correlated with ERG rearrangement status by fluorescence in situ hybridization. However, specific antibodies for ETV1, ETV4, and ETV5 are unavailable, challenging their clinical use. We developed a novel RNA in situ hybridization-based assay for the in situ detection of ETV1, ETV4, and ETV5 in formalin-fixed paraffin-embedded tissues from prostate needle biopsies, prostatectomy, and metastatic PCa specimens using RNA probes. Further, with combined RNA in situ hybridization and immunohistochemistry we identified a rare subset of PCa with dual ETS gene rearrangements in collisions of independent tumor foci. The high specificity and sensitivity of RNA in situ hybridization provides an alternate method enabling bright-field in situ detection of ETS gene aberrations in routine clinically available PCa specimens.

  6. ETV ekraanigraafika on Euroopa parimate seas / René Vilbre

    Index Scriptorium Estoniae

    Vilbre, René, 1970-

    2011-01-01

    Euroopa avalik-õiguslikle telejaamade konkurentsis valiti ETV ekraanigraafika viie parima hulka. Finaali pääses ETV kahes kategoorias - "Best design package" ja "Best use of audio". Intervjuu vaheklippide autori René Vilbrega. Võttemeeskonda kuulusid veel toimetaja Anu Välba, operaatorid Kristjan-Jaak Nuudi ja Ergo Treier

  7. Quality Assurance in Environmental Technology Verification (ETV): Analysis and Impact on the EU ETV Pilot Programme Performance

    Science.gov (United States)

    Molenda, Michał; Ratman-Kłosińska, Izabela

    2018-03-01

    Many innovative environmental technologies never reach the market because they are new and cannot demonstrate a successful track record of previous applications. This fact is a serious obstacle on their way to the market. Lack of credible data on the performance of a technology causes mistrust of investors in innovations, especially from public sector, who seek effective solutions however without compromising the technical and financial risks associated with their implementation. Environmental technology verification (ETV) offers a credible, robust and transparent process that results in a third party confirmation of the claims made by the providers about the performance of the novel environmental technologies. Verifications of performance are supported by high quality, independent test data. In that way ETV as a tool helps establish vendor credibility and buyer confidence. Several countries across the world have implemented ETV in the form of national or regional programmes. ETV in the European Union was implemented as a voluntary scheme if a form of a pilot programme. The European Commission launched the Environmental Technology Pilot Programme of the European Union (EU ETV) in 2011. The paper describes the European model of ETV set up and put to operation under the Pilot Programme of Environmental Technologies Verification of the European Union. The goal, objectives, technological scope, involved entities are presented. An attempt has been made to summarise the results of the EU ETV scheme performance available for the period of 2012 when the programme has become fully operational until the first half of 2016. The study was aimed at analysing the overall organisation and efficiency of the EU ETV Pilot Programme. The study was based on the analysis of the documents the operation of the EU ETV system. For this purpose, a relevant statistical analysis of the data on the performance of the EU ETV system provided by the European Commission was carried out.

  8. ETV1 positively regulates transcription of tumor suppressor ARF

    Science.gov (United States)

    Zynda, Evan; Jackson, Mark W; Bhattacharya, Partho; Kandel, Eugene S

    2013-01-01

    ETV1 (ETS variant 1) is a transcription factor from the ETS family and an oncogene in several types of human malignancies. Paradoxically, a predicted inactivating mutation in ETV1 was previously found in a clone of HT1080 cells with reduced activity of p53. We report that elevated expression of ETV1 makes p53-null tumor cells hypersensitive to restoration of said tumor suppressor. Furthermore, elevated levels of either wild-type ETV1 or its truncated derivative, dETV1, which mimics the product of an oncogenic rearrangement in certain tumors, results in increased expression of mRNA for p14ARF, a known activator of p53. Accordingly, expression of a luciferase reporter, which is driven by a putative ARF promoter, was elevated by concomitant expression of either ETV1 or dETV1. Our observations point to yet another example of a tumor suppressor gene being activated by a potentially oncogenic signal. A better understanding of the mechanisms that allow a cell to bypass such safeguards is needed in order to predict and prevent the development of an oncogene-tolerant state during cancer evolution. PMID:24157551

  9. Activity of etv5a and etv5b genes in the hypothalamus of fasted zebrafish is influenced by serotonin.

    Science.gov (United States)

    Mechaly, Alejandro S; Richardson, Ebony; Rinkwitz, Silke

    2017-05-15

    Serotonin has been implicated in the inhibition of food intake in vertebrates. However, the mechanisms through which serotonin acts has yet to be elucidated. Recently, ETV5 (ets variant gene 5) has been associated with obesity and food intake control mechanisms in mammals. We have analyzed a putative physiological function of the two etv5 paralogous genes (etv5a and etv5b) in neuronal food intake control in adult zebrafish that have been exposed to different nutritional conditions. A feeding assay was established and fluoxetine, a selective serotonin re-uptake inhibitor (SSRI), was applied. Gene expression changes in the hypothalamus were determined using real-time PCR. Fasting induced an up-regulation of etv5a and etv5b in the hypothalamus, whereas increased serotonin levels in the fasted fish counteracted the increase in expression. To investigate potential mechanisms the expression of further food intake control genes was determined. The results show that an increase of serotonin in fasting fish causes a reduction in the activity of genes stimulating food intake. This is in line with a previously demonstrated anorexigenic function of serotonin. Our results suggest that obesity-associated ETV5 has a food intake stimulating function and that this function is modulated through serotonin. Copyright © 2016 Elsevier Inc. All rights reserved.

  10. Helistajad ummistasid ETV saate "Foorum" telefonihääletuse

    Index Scriptorium Estoniae

    2006-01-01

    14. septembri ETV saates "Foorum" esitatud vaatajaküsimusele, kas teie arvates peaks Arnold Rüütel jätkama Eesti presidendina, vastas 20 910 televaatajat, kellest toetas praeguse presidendi jätkamist 6 381

  11. ETV uus seriaal "Vistrik" kavatseb nime muuta / Anne Vetik

    Index Scriptorium Estoniae

    Vetik, Anne

    2006-01-01

    Toimuvad ETV uue krimisarja "Vistrik" võtted, stsenarist Mihkel Ulman, režissöör Ain Prosa, produtsent Raivo Suviste, kesksetes rollides Marko Matvere, Jaan Rekkor, Elisabet Tamm, tootjaks OÜ Balti Video

  12. Specific and redundant activities of ETV1 and ETV4 in prostate cancer aggressiveness revealed by co-overexpression cellular contexts.

    Science.gov (United States)

    Mesquita, Diana; Barros-Silva, João D; Santos, Joana; Skotheim, Rolf I; Lothe, Ragnhild A; Paulo, Paula; Teixeira, Manuel R

    2015-03-10

    Genomic rearrangements involving ETS transcription factors are found in 50-70% of prostate carcinomas. While the large majority of the rearrangements involve ERG, around 10% involve members of the PEA3 subfamily (ETV1, ETV4 and ETV5). Using a panel of prostate cancer cell lines we found co-overexpression of ETV1 and ETV4 in two cell line models of advanced prostate cancer (MDA-PCa-2b and PC3) and questioned whether these PEA3 family members would cooperate in the acquisition of oncogenic properties or show functional redundancy. Using shRNAs we found that ETV1 and ETV4 have partially overlapping functions, with ETV1 being more relevant for cell invasion and ETV4 for anchorage-independent growth. In vitro expression signatures revealed the regulation of both specific and shared candidate targets that may resemble cellular mechanisms in vivo by interaction with the same intermediate partners. By combining the phenotypic impact data and the gene expression profiles of in vitro models with clinico-pathological features and gene expression profiles of ETS-subtyped tumors, we identified a set of eight genes associated with advanced stage and a set of three genes associated with higher Gleason score, supporting an oncogenic role of ETV1 and ETV4 overexpression and revealing gene sets that may be useful as prognostic markers.

  13. ACLY and ACC1 Regulate Hypoxia-Induced Apoptosis by Modulating ETV4 via α-ketoglutarate.

    Directory of Open Access Journals (Sweden)

    Melissa M Keenan

    2015-10-01

    Full Text Available In order to propagate a solid tumor, cancer cells must adapt to and survive under various tumor microenvironment (TME stresses, such as hypoxia or lactic acidosis. To systematically identify genes that modulate cancer cell survival under stresses, we performed genome-wide shRNA screens under hypoxia or lactic acidosis. We discovered that genetic depletion of acetyl-CoA carboxylase (ACACA or ACC1 or ATP citrate lyase (ACLY protected cancer cells from hypoxia-induced apoptosis. Additionally, the loss of ACLY or ACC1 reduced levels and activities of the oncogenic transcription factor ETV4. Silencing ETV4 also protected cells from hypoxia-induced apoptosis and led to remarkably similar transcriptional responses as with silenced ACLY or ACC1, including an anti-apoptotic program. Metabolomic analysis found that while α-ketoglutarate levels decrease under hypoxia in control cells, α-ketoglutarate is paradoxically increased under hypoxia when ACC1 or ACLY are depleted. Supplementation with α-ketoglutarate rescued the hypoxia-induced apoptosis and recapitulated the decreased expression and activity of ETV4, likely via an epigenetic mechanism. Therefore, ACC1 and ACLY regulate the levels of ETV4 under hypoxia via increased α-ketoglutarate. These results reveal that the ACC1/ACLY-α-ketoglutarate-ETV4 axis is a novel means by which metabolic states regulate transcriptional output for life vs. death decisions under hypoxia. Since many lipogenic inhibitors are under investigation as cancer therapeutics, our findings suggest that the use of these inhibitors will need to be carefully considered with respect to oncogenic drivers, tumor hypoxia, progression and dormancy. More broadly, our screen provides a framework for studying additional tumor cell stress-adaption mechanisms in the future.

  14. File list: Oth.PSC.05.Etv2.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.05.Etv2.AllCell mm9 TFs and others Etv2 Pluripotent stem cell SRX652259,SRX...652260 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.05.Etv2.AllCell.bed ...

  15. File list: Oth.PSC.10.Etv2.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.10.Etv2.AllCell mm9 TFs and others Etv2 Pluripotent stem cell SRX652259,SRX...652260 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.10.Etv2.AllCell.bed ...

  16. File list: Oth.PSC.20.Etv2.AllCell [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Oth.PSC.20.Etv2.AllCell mm9 TFs and others Etv2 Pluripotent stem cell SRX652260,SRX...652259 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Oth.PSC.20.Etv2.AllCell.bed ...

  17. Clonal origins of ETV6-RUNX1+ acute lymphoblastic leukemia

    DEFF Research Database (Denmark)

    Alpar, D.; Wren, D.; Ermini, Luca

    2015-01-01

    Studies on twins with concordant acute lymphoblastic leukemia (ALL) have revealed that ETV6-RUNX1 gene fusion is a common, prenatal genetic event with other driver aberrations occurring subclonally and probably postnatally. The fetal cell type that is transformed by ETV6-RUNX1 is not identified...... by such studies or by the analysis of early B-cell lineage phenotype of derived progeny. Ongoing, clonal immunoglobulin (IG) and cross-lineage T-cell receptor (TCR) gene rearrangements are features of B-cell precursor leukemia and commence at the pro-B-cell stage of normal B-cell lineage development. We reasoned...

  18. AFSC/NMML/CCEP: Northern fur seal demography at San Miguel Island, California, 1974 - 2014

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The National Marine Mammal Laboratories' California Current Ecosystem Program (AFSC/NOAA) initiated a long-term marking program of northern fur seals (Callorhinus...

  19. ETV noortekoor võitis Šveitsi koorifestivali peapreemia

    Index Scriptorium Estoniae

    2009-01-01

    ETV noortekoor Külli Kiiveti juhatusel pälvis 14.-19. aprillini Šveitsis toimunud 45. rahvusvahelisel koorifestivalil "Montreux Choral Festival 2009" nii žürii peapreemia kui ka parima kava ja interpretatsiooni ning kohustusliku laulu preemia

  20. AFSC/NMML/CCEP: Food Habits of Pinnipeds at San Miguel Island, California

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The National Marine Mammal Laboratories' California Current Ecosystem Program (AFSC/NOAA) collects fecal samples to examine the diet of pinnipeds, including...

  1. AFSC/NMML/CCEP: Food habits of California sea lions in Washington, 1986 - 1999

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — From 1986 to 1999, The National Marine Mammal Laboratories' California Current Ecosystem Program (AFSC/NOAA) collected fecal samples and stomachs of male California...

  2. AFSC/NMML/CCEP: Food habits of Steller sea lions in Washington, 1993 - 1999

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — From 1993 to 1999, The National Marine Mammal Laboratories' California Current Ecosystem Program (AFSC/NOAA) collected fecal samples from Steller sea lions in...

  3. Elina Hokkaneni ootab ees ETV "Laulukarusselli" finaal / Ülle Lätte

    Index Scriptorium Estoniae

    Lätte, Ülle, 1955-

    2008-01-01

    ETVs 22. septembril laste lauluvõistlusel "Laulukarussell 2008" esinenud Jõgevamaa lauljate seast pääses finaalsaatesse Helina Hokkanen Põltsamaalt (juhendajaks Tiia Kaeramaa), saate lindistusest

  4. False positivity of ETV6/RUNX1 detected by FISH in healthy newborns and adults

    DEFF Research Database (Denmark)

    Kusk, Maria Schioldan; Lausten-Thomsen, Ulrik; Andersen, Mette Klarskov

    2014-01-01

    fluorescence in situ hybridization (FISH) (FISH probe sets, we screened 179,000 cells from ETV6-RUNX1-positive dilution series, healthy adults and random cord blood samples. The t(12;21) single fusion extra signal translocation probe and the ETV6 break apart probe...

  5. Joint ETV/NOWATECH test plan for the Sorbisense GSW40 passive sampler

    Science.gov (United States)

    The joint test plan is the implementation of a test design developed for verification of the performance of an environmental technology following the NOWATECH ETV method. The verification is a joint verification with the US EPA ETV scheme and the Advanced Monitoring Systems Cent...

  6. Prevalence of t(12;21)[ETV6-RUNX1]-positive cells in healthy neonates

    DEFF Research Database (Denmark)

    Lausten-Thomsen, Ulrik; Madsen, Hans O.; Vestergaard, Therese Risom

    2011-01-01

    t(12;21)(p13;q22)[ETV6-RUNX1] is the most common chromosomal translocation in childhood acute lymphoblastic leukemia, and it can often be backtracked to Guthrie cards supporting prenatal initiation and high levels of circulating t(12;21)-positive cells at birth. To explore the prevalence of ETV6...

  7. Near term electric test vehicle ETV-2 (Engineering Materials)

    Energy Technology Data Exchange (ETDEWEB)

    Engineering drawings are provided for ETV-2, a unique battery-powered passenger vehicle has been developed that provides a significant improvement over conventional electric vehicle performance, particularly during stop-and-go driving. The vehicle is unique in two major respects: (1) the power system incorporates a flywheel that stores energy during regenerative braking and makes possible the acceleration capability needed to keep up with traffic without reducing range to unacceptable values; and (2) lightweight plastic materials are used for the vehicle unibody to minimize weight and increase range. Reference DOE/CS/51213-01. (WHK)

  8. THE PEACE CORPS EDUCATIONAL TELEVISION (ETV) PROJECT IN COLOMBIA--TWO YEARS OF RESEARCH. RESEARCH REPORT NO. 6, INSTRUCTIONAL TELEVISION FOR THE IN-SERVICE TRAINING OF THE COLOMBIAN TEACHER.

    Science.gov (United States)

    COMSTOCK, GEORGE; MACCOBY, NATHAN

    IN ORDER TO EVALUATE THE EFFECTIVENESS OF A 17-PROGRAM TELEVISED COURSE IN MODERN MATHEMATICS FOR PRIMARY SCHOOL TEACHERS PARTICIPATING IN THE PEACE CORPS ETV PROJECT, A MATH TEST AND A QUESTIONNAIRE WERE ADMINISTERED TO 1341 TEACHERS, DIVIDED BETWEEN COURSE VIEWERS AND NON-VIEWERS. MORE THAN HALF OF THE TEACHERS HAD VIEWED MORE THAN HALF OF THE…

  9. Hepatocyte growth factor improves direct reprogramming of fibroblasts towards endothelial progenitor cells via ETV2 transduction

    Directory of Open Access Journals (Sweden)

    Phuc Van Pham

    2016-09-01

    Full Text Available Human fibroblasts can be differentiated into endothelial progenitor cells by direct reprogramming via ETV-2 transfection. Previously, we have shown that the efficacy of direct reprogramming can be enhanced by hypoxia treatment. In this study, we aim to investigate whether the efficacy of direct reprogramming of fibroblasts into EPCs via Ets variant gene 2 (ETV2 transfection can be increased with hepatocyte growth factor (HGF treatment. Foreskin-derived fibroblasts were cultured in standard medium (DMEM/F12 supplemented with fetal bovine serum. They were then transduced with a viral vector expressing ETV2 in culture medium supplemented with HGF. The transduced fibroblasts were cultured in endothelial cell medium supplemented with HGF for 28 days. The efficacy of direct reprogramming was evaluated based on expression of CD31 and VEGFR2 markers by transduced cells. Phenotypic and functional characterization of induced EPCs were also confirmed by expression of particular genes and in vitro angiogenesis assays. Our results showed that HGF significantly increased the efficacy of direct reprogramming of fibroblasts towards EPCs via ETV2 transcription factors; efficiency increased from 5.41+/-1.51% for ETV2 transduction alone to 12.31+/-2.15% for ETV2 transduction combined with HGF treatment. These findings suggest the rationale for combined use of ETV2 and HGF in direct in vitro reprogramming of fibroblasts into EPCs. [Biomed Res Ther 2016; 3(9.000: 836-843

  10. ETV5 Regulates Sertoli Cell Chemokines Involved in Mouse Stem/Progenitor Spermatogonia Maintenance

    Science.gov (United States)

    Simon, Liz; Ekman, Gail C; Garcia, Thomas; Carnes, Kay; Zhang, Zhen; Murphy, Theresa; Murphy, Kenneth M; Hess, Rex A; Cooke, Paul S; Hofmann, Marie–Claude

    2010-01-01

    Spermatogonial stem cells are the only stem cells in the body that transmit genetic information to offspring. Although growth factors responsible for self–renewal of these cells are known, the factors and mechanisms that attract and physically maintain these cells within their microenvironment are poorly understood. Mice with targeted disruption of Ets variant gene 5 (Etv5) show total loss of stem/progenitor spermatogonia following the first wave of spermatogenesis, resulting in a Sertoli cell–only phenotype and aspermia. Microarray analysis of primary Sertoli cells from Etv5 knockout (Etv5−/−) versus wild–type (WT) mice revealed significant decreases in expression of several chemokines. Chemotaxis assays demonstrated that migration of stem/progenitor spermatogonia toward Etv5−/− Sertoli cells was significantly decreased compared to migration toward WT Sertoli cells. Interestingly, differentiating spermatogonia, spermatocytes, and round spermatids were not chemoattracted by WT Sertoli cells, whereas stem/progenitor spermatogonia showed a high and significant chemotactic index. Rescue assays using recombinant chemokines indicated that C-C-motif ligand 9 (CCL9) facilitates Sertoli cell chemoattraction of stem/progenitor spermatogonia, which express C-C-receptor type 1 (CCR1). In addition, there is protein–DNA interaction between ETV5 and Ccl9, suggesting that ETV5 might be a direct regulator of Ccl9 expression. Taken together, our data show for the first time that Sertoli cells are chemoattractive for stem/progenitor spermatogonia, and that production of specific chemokines is regulated by ETV5. Therefore, changes in chemokine production and consequent decreases in chemoattraction by Etv5−/− Sertoli cells helps to explain stem/progenitor spermatogonia loss in Etv5−/− mice. PMID:20799334

  11. Valik uusi Eesti animafilme jõuab täna ETV ekraanile

    Index Scriptorium Estoniae

    pPIK mare 2010

    2006-01-01

    ETV näitab kuut eesti uut animafilmi : Mati Küti "Une instituut", Rao Heidmetsa "Pärlimees", Pärtel Talli "Teatriporgand", Riho Undi "Vennad Karusüdamed", Priit Tenderi "Sõnum naabritele", Mait Laasi "Generatsioon"

  12. Mammary analogue secretory carcinoma of salivary glands: a clinicopathologic and molecular study including 2 cases harboring ETV6-X fusion.

    Science.gov (United States)

    Ito, Yohei; Ishibashi, Kenichiro; Masaki, Ayako; Fujii, Kana; Fujiyoshi, Yukio; Hattori, Hideo; Kawakita, Daisuke; Matsumoto, Manabu; Miyabe, Satoru; Shimozato, Kazuo; Nagao, Toshitaka; Inagaki, Hiroshi

    2015-05-01

    Mammary analogue secretory carcinoma (MASC) is a recently described low-grade carcinoma with morphologic and genetic similarity, including ETV6-NTRK3 fusion, to secretory carcinoma of the breast. ETV6 is frequently involved in other epithelial and nonepithelial tumors, and many fusion partners of ETV6 have been reported. In the present study, 14 Japanese MASC cases were clinicopathologically and molecularly analyzed. The median age of the patients was 39 years, and the male:female ratio was 6:8. All cases showed histopathologic findings compatible with those previously described for MASC and harbored an ETV6 split as visualized by fluorescence in situ hybridization. Two cases showed thick fibrous septa and invasive features including vascular or perineural tumor involvement, findings that are rare in MASC. In addition, in these 2 cases, non-NTRK3 genes appeared to fuse with ETV6 (ETV6-X fusion). NTRK1 and NTRK2, both members of the NTRK family, were not involved. Of the 14 MASC cases, the ETV6-NTRK3 fusion transcript was positive in 6 cases, and the relative expression level of the ETV6-NTRK3 fusion transcript was variable, ranging from 1 to 5.8. Results of the present study of MASC suggest that (1) ETV6 occasionally fuses with unknown non-NTRK3 genes, (2) ETV6-X cases might have an invasive histology, (3) for molecular diagnosis of MASC, fluorescence in situ hybridization to detect ETV6 splits is the method of choice, and (4) the expression level of the ETV6-NTRK3 fusion transcript is considerably variable. These findings provide a novel insight into the oncogenesis, histopathology, diagnosis, treatment, and prognosis of this newly recognized carcinoma.

  13. AFSC/NMML/CCEP: Natality rates of California sea lions at San Miguel Island, California during 1987-2008

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The National Marine Mammal Laboratories' California Current Ecosystem Program (AFSC/NOAA) initiated a long-term marking program of California sea lions (Zalophus...

  14. ETV4 Facilitates Cell-Cycle Progression in Pancreatic Cells through Transcriptional Regulation of Cyclin D1.

    Science.gov (United States)

    Tyagi, Nikhil; Deshmukh, Sachin K; Srivastava, Sanjeev K; Azim, Shafquat; Ahmad, Aamir; Al-Ghadhban, Ahmed; Singh, Ajay P; Carter, James E; Wang, Bin; Singh, Seema

    2017-11-08

    The ETS family transcription factor ETV4 is aberrantly expressed in a variety of human tumors and plays an important role in carcinogenesis through upregulation of relevant target gene expression. Here, it is demonstrated that ETV4 is overexpressed in pancreatic cancer tissues as compared with the normal pancreas, and is associated with enhanced growth and rapid cell-cycle progression of pancreatic cancer cells. ETV4 expression was silenced through stable expression of a specific short hairpin RNA (shRNA) in two pancreatic cancer cell lines (ASPC1 and Colo357), while it was ectopically expressed in BXPC3 cells. Silencing of ETV4 in ASPC1 and Colo357 cells reduced the growth by 55.3% and 38.9%, respectively, while forced expression of ETV4 in BXPC3 cells increased the growth by 46.8% in comparison with respective control cells. Furthermore, ETV4-induced cell growth was facilitated by rapid transition of cells from G1- to S-phase of the cell cycle. Mechanistic studies revealed that ETV4 directly regulates the expression of Cyclin D1 CCND1, a protein crucial for cell-cycle progression from G1- to S-phase. These effects on the growth and cell cycle were reversed by the forced expression of Cyclin D1 in ETV4-silenced pancreatic cancer cells. Altogether, these data provide the first experimental evidence for a functional role of ETV4 in pancreatic cancer growth and cell-cycle progression.Implications: The functional and mechanistic data presented here regarding ETV4 in pancreatic cancer growth and cell-cycle progression suggest that ETV4 could serve as a potential biomarker and novel target for pancreatic cancer therapy. Mol Cancer Res; 1-10. ©2017 AACR. ©2017 American Association for Cancer Research.

  15. THE PEACE CORPS EDUCATIONAL TELEVISION (ETV) PROJECT IN COLOMBIA--TWO YEARS OF RESEARCH. RESEARCH REPORT NO. 3, IMPROVING THE EFFECTIVENESS OF THE UTILIZATION VOLUNTEER AND THE UTILIZATION OF ETV BY THE COLOMBIAN TEACHER.

    Science.gov (United States)

    COMSTOCK, GEORGE; MACCOBY, NATHAN

    THIS EXPERIMENT IN THE ETV PROJECT SHOWED THE SUPERIORITY OF PUPIL PRACTICE AS A TEACHING METHOD AND STUDIED THE EFFECTIVENESS OF THE UTILIZATION VOLUNTEER (A PEACE CORPS VOLUNTEER CONCERNED WITH IMPLEMENTING ETV IN THE SCHOOLS) IN DIFFERENT SITUATIONS. THREE TREATMENTS WERE ARRANGED--(1) ACTIVE PUPIL PRACTICE WHERE BROADCASTS WERE COMBINED WITH…

  16. ETV6-NTRK3 as a therapeutic target of small molecule inhibitor PKC412

    Energy Technology Data Exchange (ETDEWEB)

    Chi, Hoang Thanh, E-mail: kk086406@mgs.k.u-tokyo.ac.jp [Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo 108-8639 (Japan); Ly, Bui Thi Kim [Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo 108-8639 (Japan); Kano, Yasuhiko [Division of Hematology and Medical Oncology, Tochigi Cancer Center, Tochigi 321-0293 (Japan); Tojo, Arinobu [Division of Molecular Therapy, Department of Hematology/Oncology, Research Hospital, The Institute of Medical Science, The University of Tokyo, Tokyo (Japan); Watanabe, Toshiki [Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo 108-8639 (Japan); Sato, Yuko [Musashimurayama Hospital, Musashimurayama, Tokyo 208-0011 (Japan)

    2012-12-07

    Highlights: Black-Right-Pointing-Pointer ETV6-NTRK3 is an oncogene with transformation activity in multiple cell lineages. Black-Right-Pointing-Pointer PKC412 could block ETV6-NTRK3 activation. Black-Right-Pointing-Pointer Loss of ETV6-NTRK3 phosphorylation leads to inactivation of its downstream signaling pathway. Black-Right-Pointing-Pointer Inhibition of ETV6-NTRK3 activation by PKC412 could be a novel strategy for the treatment. -- Abstract: The ETV6-NTRK3 (EN) fusion gene which encodes a chimeric tyrosine kinase was first identified by cloning of the t(12;15)(p13;q25) translocation in congenital fibrosarcoma (CFS). Since then, EN has been also found in congenital mesoblastic nephroma (CMN), secretory breast carcinoma (SBC) and acute myelogenous leukemia (AML). Using IMS-M2 and M0-91 cell lines harboring the EN fusion gene, and Ba/F3 cells stably transfected with EN, we demonstrated that PKC412, also known as midostaurin, is an inhibitor of EN. Inhibition of EN activity by PKC412 suppressed the activity of it downstream molecules leading to inhibition of cell proliferation and induction of apoptosis. Our data for the first time suggested that PKC412 could serve as therapeutic drug for treatment of patients with this fusion.

  17. ETV6-RUNX1 Rearrangement in Tunisian Pediatric B-Lineage Acute Lymphoblastic Leukemia

    Directory of Open Access Journals (Sweden)

    Abir Gmidène

    2009-01-01

    Full Text Available In this study, Forty-one out of fifty-seven Tunisian children with B-lineage acute lymphoblastic leukemia (B-ALL, and without cytogenetically detectable recurrent abnormalities at the time of the diagnosis, were evaluated by fluorescence in situ hybridization (FISH for the t(12;21. This translocation leads ETV6-RUNX1 (previously TEL-AML1 fusion gene. 16 patients (28% had ETV6-RUNX1 rearrangement. In addition to this rearrangement, two cases showed a loss of the normal ETV6 allele, and three others showed an extra signal of the RUNX1 gene. Seven patients without ETV6-RUNX1 rearrangement showed extra signals of the RUNX1 gene. One out of the 7 patients was also associated with a t(3;12 identified by FISH. This is the first Tunisian study in which we report the incidence of t(12;21 among childhood B-lineage ALL and in which we have found multiple copies of RUNX1. Finally, our findings confirm that additional or secondary genetic changes are commonly encountered in pediatric B-lineage ALL with ETV6-RUNX1 gene fusion which is envisaged to play a pivotal role in disease progression.

  18. A Double Negative Loop Comprising ETV6/RUNX1 and MIR181A1 Contributes to Differentiation Block in t(12;21-Positive Acute Lymphoblastic Leukemia.

    Directory of Open Access Journals (Sweden)

    Yung-Li Yang

    Full Text Available Childhood acute lymphoblastic leukemia (ALL with t(12;21, which results in expression of the ETV6/RUNX1 fusion gene, is the most common chromosomal lesion in precursor-B (pre-B ALL. We identified 17 microRNAs that were downregulated in ETV6/RUNX1+ compared with ETV6/RUNX1- clinical samples. Among these microRNAs, miR-181a-1 was the most significantly reduced (by ~75%; P < 0.001. Using chromatin immunoprecipitation, we demonstrated that ETV6/RUNX1 directly binds the regulatory region of MIR181A1, and knockdown of ETV6/RUNX1 increased miR-181a-1 level. We further showed that miR-181a (functional counterpart of miR-181a-1 could target ETV6/RUNX1 and cause a reduction in the level of the oncoprotein ETV6/RUNX1, cell growth arrest, an increase in apoptosis, and induction of cell differentiation in ETV6/RUNX1+ cell line. Moreover, ectopic expression of miR-181a also resulted in decreased CD10 hyperexpression in ETV6/RUNX1+ primary patient samples. Taken together, our results demonstrate that MIR181A1 and ETV6/RUNX1 regulate each other, and we propose that a double negative loop involving MIR181A1 and ETV6/RUNX1 may contribute to ETV6/RUNX1-driven arrest of differentiation in pre-B ALL.

  19. Modeling the evolution of ETV6-RUNX1-induced B-cell precursor acute lymphoblastic leukemia in mice.

    Science.gov (United States)

    van der Weyden, Louise; Giotopoulos, George; Rust, Alistair G; Matheson, Louise S; van Delft, Frederik W; Kong, Jun; Corcoran, Anne E; Greaves, Mel F; Mullighan, Charles G; Huntly, Brian J; Adams, David J

    2011-07-28

    The t(12;21) translocation that generates the ETV6-RUNX1 (TEL-AML1) fusion gene, is the most common chromosomal rearrangement in childhood cancer and is exclusively associated with B-cell precursor acute lymphoblastic leukemia (BCP-ALL). The translocation arises in utero and is necessary but insufficient for the development of leukemia. Single-nucleotide polymorphism array analysis of ETV6-RUNX1 patient samples has identified multiple additional genetic alterations; however, the role of these lesions in leukemogenesis remains undetermined. Moreover, murine models of ETV6-RUNX1 ALL that faithfully recapitulate the human disease are lacking. To identify novel genes that cooperate with ETV6-RUNX1 in leukemogenesis, we generated a mouse model that uses the endogenous Etv6 locus to coexpress the Etv6-RUNX1 fusion and Sleeping Beauty transposase. An insertional mutagenesis screen was performed by intercrossing these mice with those carrying a Sleeping Beauty transposon array. In contrast to previous models, a substantial proportion (20%) of the offspring developed BCP-ALL. Isolation of the transposon insertion sites identified genes known to be associated with BCP-ALL, including Ebf1 and Epor, in addition to other novel candidates. This is the first mouse model of ETV6-RUNX1 to develop BCP-ALL and provides important insight into the cooperating genetic alterations in ETV6-RUNX1 leukemia.

  20. Overexpression of ETV4 protein in triple-negative breast cancer is associated with a higher risk of distant metastasis

    Directory of Open Access Journals (Sweden)

    Yuan ZY

    2014-09-01

    Full Text Available Zhong-Yu Yuan,1–3,* Ting Dai,1,2,* Shu-Sen Wang,1–3 Rou-Jun Peng,1–3 Xing-Hua Li,1,2 Tao Qin,1–3 Li-Bing Song,1,2 Xi Wang1,2,41State Key Laboratory of Oncology in South China, Guangzhou, People's Republic of China; 2Collaborative Innovation Center for Cancer Medicine, Guangzhou, People's Republic of China; 3Department of Medical Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, People's Republic of China; 4Department of Breast Oncology, Sun Yat-Sen University Cancer Center, Guangzhou, People's Republic of China  *These authors contributed equally to this work Background: Patients with triple-negative breast cancer (TNBC present a higher probability of distant metastasis and lack of effective targeted therapy. ETS translocation variant 4 (ETV4 is an ETS (E-26 transcription factor and has been associated with tumor metastasis. However, the clinical and functional significance of ETV4 in TNBC still remains unclear. Methods: A human tumor metastasis polymerase chain reaction array was used to profile differential expression of tumor metastasis-related genes in TNBC tissue. Real-time reverse transcription and Western blot analyses were performed to verify ETV4 expression in TNBC cells and tissue. Immunohistochemistry was used to detect expression of ETV4 protein in 135 TNBC tissue samples for association between ETV4 protein expression and clinical outcomes. Results: A total total of eight upregulated (CCL7, KISS1, MET, MMP7, NR4A3, ETV4, TIMP3, and TSHR and three downregulated (ITGA7, SSTR, and MMP2 genes were identified between TNBC tissue and the luminal subtype of breast cancer tissue. ETV4 messenger ribonucleic acid was more than five-fold upregulated in TNBC tissue compared with the control tissue. ETV4 overexpression was found in 57.0% of 135 TNBC cases. Overexpression of ETV4 protein was associated with an advanced stage and a higher proportion of positive lymph node and lymphovascular invasion. Patients with an ETV4

  1. AFSC/NMML/CCEP: Harbor seal demography in Washington; capture, tagging, branding data from 1981 to 2007

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The National Marine Mammal Laboratories' California Current Ecosystem Program (AFSC/NOAA) in collaboration with Washington Department of Fish and Wildlife captured...

  2. Electrostatic control of DNA intersegmental translocation by the ETS transcription factor ETV6.

    Science.gov (United States)

    Vo, Tam; Wang, Shuo; Poon, Gregory M K; Wilson, W David

    2017-08-11

    To find their DNA target sites in complex solution environments containing excess heterogeneous DNA, sequence-specific DNA-binding proteins execute various translocation mechanisms known collectively as facilitated diffusion. For proteins harboring a single DNA contact surface, long-range translocation occurs by jumping between widely spaced DNA segments. We have configured biosensor-based surface plasmon resonance to directly measure the affinity and kinetics of this intersegmental jumping by the ETS-family transcription factor ETS variant 6 (ETV6). To isolate intersegmental target binding in a functionally defined manner, we pre-equilibrated ETV6 with excess salmon sperm DNA, a heterogeneous polymer, before exposing the nonspecifically bound protein to immobilized oligomeric DNA harboring a high-affinity ETV6 site. In this way, the mechanism of ETV6-target association could be toggled electrostatically through varying NaCl concentration in the bulk solution. Direct measurements of association and dissociation kinetics of the site-specific complex indicated that 1) freely diffusive binding by ETV6 proceeds through a nonspecific-like intermediate, 2) intersegmental jumping is rate-limited by dissociation from the nonspecific polymer, and 3) dissociation of the specific complex is independent of the history of complex formation. These results show that target searches by proteins with an ETS domain, such as ETV6, whose single DNA-binding domain cannot contact both source and destination sites simultaneously, are nonetheless strongly modulated by intersegmental jumping in heterogeneous site environments. Our findings establish biosensors as a general technique for directly and specifically measuring target site search by DNA-binding proteins via intersegmental translocation. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

  3. The Drosophila ETV5 Homologue Ets96B: Molecular Link between Obesity and Bipolar Disorder.

    Directory of Open Access Journals (Sweden)

    Michael J Williams

    2016-06-01

    Full Text Available Several reports suggest obesity and bipolar disorder (BD share some physiological and behavioural similarities. For instance, obese individuals are more impulsive and have heightened reward responsiveness, phenotypes associated with BD, while bipolar patients become obese at a higher rate and earlier age than people without BD; however, the molecular mechanisms of such an association remain obscure. Here we demonstrate, using whole transcriptome analysis, that Drosophila Ets96B, homologue of obesity-linked gene ETV5, regulates cellular systems associated with obesity and BD. Consistent with a role in obesity and BD, loss of nervous system Ets96B during development increases triacylglyceride concentration, while inducing a heightened startle-response, as well as increasing hyperactivity and reducing sleep. Of notable interest, mouse Etv5 and Drosophila Ets96B are expressed in dopaminergic-rich regions, and loss of Ets96B specifically in dopaminergic neurons recapitulates the metabolic and behavioural phenotypes. Moreover, our data indicate Ets96B inhibits dopaminergic-specific neuroprotective systems. Additionally, we reveal that multiple SNPs in human ETV5 link to body mass index (BMI and BD, providing further evidence for ETV5 as an important and novel molecular intermediate between obesity and BD. We identify a novel molecular link between obesity and bipolar disorder. The Drosophila ETV5 homologue Ets96B regulates the expression of cellular systems with links to obesity and behaviour, including the expression of a conserved endoplasmic reticulum molecular chaperone complex known to be neuroprotective. Finally, a connection between the obesity-linked gene ETV5 and bipolar disorder emphasizes a functional relationship between obesity and BD at the molecular level.

  4. ETV6/RUNX1 Induces Reactive Oxygen Species and Drives the Accumulation of DNA Damage in B Cells

    Directory of Open Access Journals (Sweden)

    Hans-Peter Kantner

    2013-11-01

    Full Text Available The t(12;21(p13;q22 chromosomal translocation is the most frequent translocation in childhood B cell precursor-acute lymphoblastic leukemia and results in the expression of an ETV6/RUNX1 fusion protein. The frequency of ETV6/RUNX1 fusions in newborns clearly exceeds the leukemia rate revealing that additional events occur in ETV6/RUNX1-positive cells for leukemic transformation. Hitherto, the mechanisms triggering these second hits remain largely elusive. Thus, we generated a novel ETV6/RUNX1 transgenic mouse model where the expression of the fusion protein is restricted to CD19+ B cells. These animals harbor regular B cell development and lack gross abnormalities. We established stable pro-B cell lines carrying the ETV6/RUNX1 transgene that allowed us to investigate whether ETV6/RUNX1 itself favors the acquisition of second hits. Remarkably, these pro-B cell lines as well as primary bone marrow cells derived from ETV6/RUNX1 transgenic animals display elevated levels of reactive oxygen species (ROS as tested with ETV6/RUNX1 transgenic dihydroethidium staining. In line, intracellular phospho-histone H2AX flow cytometry and comet assay revealed increased DNA damage indicating that ETV6/RUNX1 expression enhances ROS. On the basis of our data, we propose the following model: the expression of ETV6/RUNX1 creates a preleukemic clone and leads to increased ROS levels. These elevated ROS favor the accumulation of secondary hits by increasing genetic instability and doublestrand breaks, thus allowing preleukemic clones to develop into fully transformed leukemic cells.

  5. Mammary Analogue Secretory Carcinoma of Salivary Glands: Molecular Analysis of 25 ETV6 Gene Rearranged Tumors With Lack of Detection of Classical ETV6-NTRK3 Fusion Transcript by Standard RT-PCR: Report of 4 Cases Harboring ETV6-X Gene Fusion.

    Science.gov (United States)

    Skálová, Alena; Vanecek, Tomas; Simpson, Roderick H W; Laco, Jan; Majewska, Hanna; Baneckova, Martina; Steiner, Petr; Michal, Michal

    2016-01-01

    ETV6 gene abnormalities are well described in tumor pathology. Many fusion partners of ETV6 have been reported in a variety of epithelial and hematological malignancies. In salivary gland tumor pathology, however, the ETV6-NTRK3 translocation is specific for mammary analogue secretory carcinoma (MASC), and has not been documented in any other salivary tumor type. The present study comprised a clinical and molecular analysis of 25 cases morphologically and immunohistochemically typical of MASC. They all also displayed the ETV6 rearrangement as visualized by fluorescent in situ hybridization but lacked the classical ETV6-NTRK3 fusion transcript by standard reverse-transcriptase-polymerase chain reaction. In 4 cases, the classical fusion transcript was found by more sensitive, nested reverse-transcription-polymerase chain reaction. Five other cases harbored atypical fusion transcripts as detected by both standard and nested reverse-transcription-polymerase chain reaction. In addition, fluorescent in situ hybridization with an NTRK3 break-apart probe was also performed; rearrangement of NTRK3 gene was detected in 16 of 25 cases. In 3 other cases, the tissue was not analyzable, and in 2 further cases analysis could not be performed because of a lack of appropriate tissue material. Finally, in the 4 remaining cases whose profile was NTRK3 split-negative and ETV6 split-positive, unknown (non-NTRK) genes appeared to fuse with ETV6 (ETV6-X fusion). In looking for possible fusion partners, analysis of rearrangement of other kinase genes known to fuse with ETV6 was also performed, but without positive results. Although numbers were small, correlating the clinico-pathologic features of the 4 ETV6-X fusion tumors and 5 MASC cases with atypical fusion transcripts raises the possibility of that they may behave more aggressively.

  6. AAV-mediated gene transfer of the obesity-associated gene Etv5 in rat midbrain does not affect energy balance or motivated behavior.

    Directory of Open Access Journals (Sweden)

    Arjen J Boender

    Full Text Available Several genome-wide association studies have implicated the transcription factor E-twenty- six version 5 (Etv5 in the regulation of body mass index. Further substantiating the role of Etv5 in feeding behavior are the findings that targeted disruption of Etv5 in mice leads to decreased body weight gain and that expression of Etv5 is decreased in the ventral tegmental area and substantia nigra pars compacta (VTA/SNpc after food restriction. As Etv5 has been suggested to influence dopaminergic neurotransmission by driving the expression of genes that are responsible for the synthesis and release of dopamine, we investigated if expression levels of Etv5 are dependent on nutritional state and subsequently influence the expression levels of tyrosine hydroxylase. While it was shown that Etv5 expression in the VTA/SNpc increases after central administration of leptin and that Etv5 was able to drive expression of tyrosine hydroxylase in vitro, AAV-mediated gene transfer of Etv5 into the VTA/SNpc of rats did not alter expression of tyrosine hydroxylase in vivo. Moreover, AAV-mediated gene transfer of Etv5 in the VTA/SNpc did not affect measures of energy balance or performances in a progressive ratio schedule. Thus, these data do not support a role for increased expression of Etv5 in the VTA/SNpc in the regulation of feeding behavior.

  7. AAV-mediated gene transfer of the obesity-associated gene Etv5 in rat midbrain does not affect energy balance or motivated behavior.

    Science.gov (United States)

    Boender, Arjen J; Koning, Nivard A; van den Heuvel, José K; Luijendijk, Mieneke C M; van Rozen, Andrea J; la Fleur, Susanne E; Adan, Roger A H

    2014-01-01

    Several genome-wide association studies have implicated the transcription factor E-twenty- six version 5 (Etv5) in the regulation of body mass index. Further substantiating the role of Etv5 in feeding behavior are the findings that targeted disruption of Etv5 in mice leads to decreased body weight gain and that expression of Etv5 is decreased in the ventral tegmental area and substantia nigra pars compacta (VTA/SNpc) after food restriction. As Etv5 has been suggested to influence dopaminergic neurotransmission by driving the expression of genes that are responsible for the synthesis and release of dopamine, we investigated if expression levels of Etv5 are dependent on nutritional state and subsequently influence the expression levels of tyrosine hydroxylase. While it was shown that Etv5 expression in the VTA/SNpc increases after central administration of leptin and that Etv5 was able to drive expression of tyrosine hydroxylase in vitro, AAV-mediated gene transfer of Etv5 into the VTA/SNpc of rats did not alter expression of tyrosine hydroxylase in vivo. Moreover, AAV-mediated gene transfer of Etv5 in the VTA/SNpc did not affect measures of energy balance or performances in a progressive ratio schedule. Thus, these data do not support a role for increased expression of Etv5 in the VTA/SNpc in the regulation of feeding behavior.

  8. Preaxial polydactyly: interactions among ETV, TWIST1 and HAND2 control anterior-posterior patterning of the limb

    Science.gov (United States)

    Zhang, Zhen; Sui, Pengfei; Dong, Aiwu; Hassell, John; Cserjesi, Peter; Chen, You-Tzung; Behringer, Richard R.; Sun, Xin

    2010-01-01

    Preaxial polydactyly (PPD) is a common limb-associated birth defect characterized by extra digit(s) in the anterior autopod. It often results from ectopic sonic hedgehog (Shh) expression in the anterior limb bud. Although several transcription factors are known to restrict Shh expression to the posterior limb bud, how they function together remains unclear. Here we provide evidence from mouse conditional knockout limb buds that the bHLH family transcription factor gene Twist1 is required to inhibit Shh expression in the anterior limb bud mesenchyme. More importantly, we uncovered genetic synergism between Twist1 and the ETS family transcription factor genes Etv4 and Etv5 (collectively Etv), which also inhibit Shh expression. Biochemical data suggest that this genetic interaction is a result of direct association between TWIST1 and ETV proteins. Previous studies have shown that TWIST1 functions by forming homodimers or heterodimers with other bHLH factors including HAND2, a key positive regulator of Shh expression. We found that the PPD phenotype observed in Etv mutants is suppressed by a mutation in Hand2, indicative of genetic antagonism. Furthermore, overexpression of ETV proteins influences the dimerization of these bHLH factors. Together, our data suggest that through biochemical interactions, the Shh expression regulators ETV, TWIST1 and HAND2 attain a precise balance to establish anterior-posterior patterning of the limb. PMID:20826535

  9. Prevalence of t(12;21)[ETV6-RUNX1]-positive cells in healthy neonates

    DEFF Research Database (Denmark)

    Lausten-Thomsen, Ulrik; Madsen, Hans Ole; Vestergaard, Therese Risom

    2011-01-01

    -RUNX1-positive cells in healthy neonates, mononuclear cells from 1417 umbilical cord blood samples were isolated within 24 hours from birth and subsequently screened for ETV6-RUNX1 transcripts using a highly sensitive real-time reverse transcription polymerase chain reaction assay. In first...

  10. The Volunteers. The Peace Corps Educational Television (ETV) Project in Colombia: Two Years of Research.

    Science.gov (United States)

    Comstock, George; And Others

    For this report on a two-year Peace Corps project designed to implement educational television (ETV) into Colombia schools, the Peace Corps Volunteers who participated are investigated. The history and experience of these Volunteers in the Peace Corps are sketched first. Next, the consequences for them of serving in a large, integrated, special…

  11. Frequency and clinical impact of ETV6/RUNX1, AF4‑MLL, and BCR ...

    African Journals Online (AJOL)

    2015-05-12

    May 12, 2015 ... Disease outcome for these patients is poor but would benefit from treatment with tyrosine kinase inhibitors and allogeneic hematopoietic stem cell transplant as noted in some studies.[19,20]. Half of the childhood ALL patients who screened positively for these fusion genes had the ETV6‑RUNX1, while the.

  12. Frequency and clinical impact of ETV6/RUNX1, AF4‑MLL, and BCR ...

    African Journals Online (AJOL)

    Frequency and clinical impact of ETV6/RUNX1, AF4‑MLL, and BCR/ABL fusion genes on features of acute lymphoblastic leukemia at presentation. ... An association exists between the fusion genes and ethnic origin of the patients (P = 0.005). There is no significant association between the abnormal fusion genes detected ...

  13. Closed-Cycle Engine Program Used to Study Brayton Power Conversion

    Science.gov (United States)

    Johnson, Paul K.

    2005-01-01

    One form of power conversion under consideration in NASA Glenn Research Center's Thermal Energy Conversion Branch is the closed-Brayton-cycle engine. In the tens-of-kilowatts to multimegawatt class, the Brayton engine lends itself to potential space nuclear power applications such as electric propulsion or surface power. The Thermal Energy Conversion Branch has most recently concentrated its Brayton studies on electric propulsion for Prometheus. One piece of software used for evaluating such designs over a limited tradeoff space has been the Closed Cycle Engine Program (CCEP). The CCEP originated in the mid-1980s from a Fortran aircraft engine code known as the Navy/NASA Engine Program (NNEP). Components such as a solar collector, heat exchangers, ducting, a pumped-loop radiator, a nuclear heat source, and radial turbomachinery were added to NNEP, transforming it into a high-fidelity design and performance tool for closed-Brayton-cycle power conversion and heat rejection. CCEP was used in the 1990s in conjunction with the Solar Dynamic Ground Test Demonstration conducted at Glenn. Over the past year, updates were made to CCEP to adapt it for an electric propulsion application. The pumped-loop radiator coolant can now be n-heptane, water, or sodium-potassium (NaK); liquid-metal pump design tables were added to accommodate the NaK fluid. For the reactor and shield, a user can now elect to calculate a higher fidelity mass estimate. In addition, helium-xenon working-fluid properties were recalculated and updated.

  14. Autoinhibition of ETV6 DNA Binding Is Established by the Stability of Its Inhibitory Helix.

    Science.gov (United States)

    De, Soumya; Okon, Mark; Graves, Barbara J; McIntosh, Lawrence P

    2016-04-24

    The ETS transcriptional repressor ETV6 (or TEL) is autoinhibited by an α-helix that sterically blocks its DNA-binding ETS domain. The inhibitory helix is marginally stable and unfolds when ETV6 binds to either specific or non-specific DNA. Using NMR spectroscopy, we show that folding of the inhibitory helix requires a buried charge-dipole interaction with helix H1 of the ETS domain. This interaction also contributes directly to autoinhibition by precluding a highly conserved dipole-enhanced hydrogen bond between the phosphodiester backbone of bound DNA and the N terminus of helix H1. To probe further the thermodynamic basis of autoinhibition, ETV6 variants were generated with amino acid substitutions introduced along the solvent exposed surface of the inhibitory helix. These changes were designed to increase the intrinsic helical propensity of the inhibitory helix without perturbing its packing interactions with the ETS domain. NMR-monitored amide hydrogen exchange measurements confirmed that the stability of the folded inhibitory helix increases progressively with added helix-promoting substitutions. This also results in progressively reinforced autoinhibition and decreased DNA-binding affinity. Surprisingly, locking the inhibitory helix onto the ETS domain by a disulfide bridge severely impairs, but does not abolish DNA binding. Weak interactions still occur via an interface displaced from the canonical ETS domain DNA-binding surface. Collectively, these studies establish a direct thermodynamic linkage between inhibitory helix stability and ETV6 autoinhibition, and demonstrate that helix unfolding does not strictly precede DNA binding. Modulating inhibitory helix stability provides a potential route for the in vivo regulation of ETV6 activity. Copyright © 2016 Elsevier Ltd. All rights reserved.

  15. Direct Reprogramming of Human Dermal Fibroblasts Into Endothelial Cells Using ER71/ETV2.

    Science.gov (United States)

    Lee, Sangho; Park, Changwon; Han, Ji Woong; Kim, Ju Young; Cho, Kyuwon; Kim, Eun Jae; Kim, Sangsung; Lee, Shin-Jeong; Oh, Se Yeong; Tanaka, Yoshiaki; Park, In-Hyun; An, Hyo Jae; Shin, Claire Min; Sharma, Shraya; Yoon, Young-Sup

    2017-03-03

    Direct conversion or reprogramming of human postnatal cells into endothelial cells (ECs), bypassing stem or progenitor cell status, is crucial for regenerative medicine, cell therapy, and pathophysiological investigation but has remained largely unexplored. We sought to directly reprogram human postnatal dermal fibroblasts to ECs with vasculogenic and endothelial transcription factors and determine their vascularizing and therapeutic potential. We utilized various combinations of 7 EC transcription factors to transduce human postnatal dermal fibroblasts and found that ER71/ETV2 (ETS variant 2) alone best induced endothelial features. KDR+ (kinase insert domain receptor) cells sorted at day 7 from ER71/ETV2-transduced human postnatal dermal fibroblasts showed less mature but enriched endothelial characteristics and thus were referred to as early reprogrammed ECs (rECs), and did not undergo maturation by further culture. After a period of several weeks' transgene-free culture followed by transient reinduction of ER71/ETV2, early rECs matured during 3 months of culture and showed reduced ETV2 expression, reaching a mature phenotype similar to postnatal human ECs. These were termed late rECs. While early rECs exhibited an immature phenotype, their implantation into ischemic hindlimbs induced enhanced recovery from ischemia. These 2 rECs showed clear capacity for contributing to new vessel formation through direct vascular incorporation in vivo. Paracrine or proangiogenic effects of implanted early rECs played a significant role in repairing hindlimb ischemia. This study for the first time demonstrates that ER71/ETV2 alone can directly reprogram human postnatal cells to functional, mature ECs after an intervening transgene-free period. These rECs could be valuable for cell therapy, personalized disease investigation, and exploration of the reprogramming process. © 2016 American Heart Association, Inc.

  16. Loss of Etv5 Decreases Proliferation and RET Levels in Neonatal Mouse Testicular Germ Cells and Causes an Abnormal First Wave of Spermatogenesis1

    Science.gov (United States)

    Tyagi, Gaurav; Carnes, Kay; Morrow, Carla; Kostereva, Natalia V.; Ekman, Gail C.; Meling, Daryl D.; Hostetler, Chris; Griswold, Michael; Murphy, Kenneth M.; Hess, Rex A.; Hofmann, Marie-Claude; Cooke, Paul S.

    2009-01-01

    Mice that are ets variant gene 5 (ETV5) null (Etv5−/−) undergo the first wave of spermatogenesis but lose all spermatogonial stem cells (SSCs) during this time. The SSC loss in Etv5−/− mice begins during the neonatal period, suggesting a role for ETV5 in SSC self-renewal during this period. Herein, we show that Etv5 mRNA was present in perinatal mouse testis and that ETV5 was expressed in fetal Sertoli cells and by germ cells and Sertoli cells during the neonatal period. Transplantation of Etv5−/− germ cells failed to establish spermatogenesis in W/Wv mice testes, indicating that germ cell ETV5 has a key role in establishment or self-renewal of transplanted SSCs. The SSC self-renewal is stimulated by glial cell-derived neurotrophic factor (GDNF) acting through the RET/GDNF family receptor alpha 1 (GFRA1) receptor complex in SSCs. Immunohistochemistry, quantitative PCR, and laser capture microdissection revealed decreased RET mRNA and protein expression in spermatogonia of neonatal Etv5−/− mice by Postnatal Days 4–8, indicating that disrupted GDNF/RET/GFRA1 signaling may occur before initial spermatogonial stem/progenitor cell decrease. Etv5−/− spermatogonia had reduced proliferation in vivo and in vitro. Decreased cell proliferation may cause the observed decreases in the number of type A spermatogonia (Postnatal Day 17) and daily sperm production (Postnatal Day 30) in Etv5−/− mice, indicating quantitative impairments in the first wave of spermatogenesis. In conclusion, ETV5 is expressed beginning in fetal Sertoli cells and can potentially have effects on neonatal Sertoli cells and germ cells. In addition, ETV5 has critical effects on neonatal spermatogonial proliferation, which may involve impaired signaling through the RET receptor. PMID:19369650

  17. Ret and Etv4 Promote Directed Movements of Progenitor Cells during Renal Branching Morphogenesis.

    Directory of Open Access Journals (Sweden)

    Paul Riccio

    2016-02-01

    Full Text Available Branching morphogenesis of the epithelial ureteric bud forms the renal collecting duct system and is critical for normal nephron number, while low nephron number is implicated in hypertension and renal disease. Ureteric bud growth and branching requires GDNF signaling from the surrounding mesenchyme to cells at the ureteric bud tips, via the Ret receptor tyrosine kinase and coreceptor Gfrα1; Ret signaling up-regulates transcription factors Etv4 and Etv5, which are also critical for branching. Despite extensive knowledge of the genetic control of these events, it is not understood, at the cellular level, how renal branching morphogenesis is achieved or how Ret signaling influences epithelial cell behaviors to promote this process. Analysis of chimeric embryos previously suggested a role for Ret signaling in promoting cell rearrangements in the nephric duct, but this method was unsuited to study individual cell behaviors during ureteric bud branching. Here, we use Mosaic Analysis with Double Markers (MADM, combined with organ culture and time-lapse imaging, to trace the movements and divisions of individual ureteric bud tip cells. We first examine wild-type clones and then Ret or Etv4 mutant/wild-type clones in which the mutant and wild-type sister cells are differentially and heritably marked by green and red fluorescent proteins. We find that, in normal kidneys, most individual tip cells behave as self-renewing progenitors, some of whose progeny remain at the tips while others populate the growing UB trunks. In Ret or Etv4 MADM clones, the wild-type cells generated at a UB tip are much more likely to remain at, or move to, the new tips during branching and elongation, while their Ret-/- or Etv4-/- sister cells tend to lag behind and contribute only to the trunks. By tracking successive mitoses in a cell lineage, we find that Ret signaling has little effect on proliferation, in contrast to its effects on cell movement. Our results show that Ret/Etv

  18. Small Molecule Inhibitors of ERG and ETV1 in Prostate Cancer

    Science.gov (United States)

    2016-06-01

    Award Number: W81XWH-12-1-0399 TITLE: Small Molecule Inhibitors of ERG and ETV1 in Prostate Cancer PRINCIPAL INVESTIGATOR: Colm Morrissey...REPORT DATE June 2016 2. REPORT TYPE Final 3. DATES COVERED 1Sep2012 - 31Mar2016 4. TITLE AND SUBTITLE 5a. CONTRACT NUMBER Small Molecule Inhibitors...utilizing xenograft models to test the hypothesis that targeting a member of the ETS transcription factor family with small molecules such as YK-4-279

  19. Mammary analogue secretory carcinoma of salivary glands: a new entity associated with ETV6 gene rearrangement.

    Science.gov (United States)

    Majewska, Hanna; Skálová, Alena; Stodulski, Dominik; Klimková, Adéla; Steiner, Petr; Stankiewicz, Czesław; Biernat, Wojciech

    2015-03-01

    Mammary analogue secretory carcinoma (MASC) is a recently described salivary gland tumour that harbours the recurrent ETV6-NTRK3 translocation. This is the first series of MASC cases identified in the historic cohort of carcinomas of salivary glands with clinical/pathological correlation and follow-up data. We reviewed 183 primary carcinomas of major and minor salivary glands resected at the Medical University of Gdańsk, Poland, between 1992 and 2012. Based on morphology and immunohistochemistry, cases suspicious for MASC were selected, and the diagnosis was confirmed by fluorescence in situ hybridization (FISH) for ETV6 rearrangement and by RT-PCR for the ETV6-NTRK3 fusion transcript. Seven carcinomas met the criteria of MASC, as they exhibited a typical appearance with solid/microcystic and papillary architecture and intraluminal secretions, and cells completely devoid of basophilic cytoplasmic zymogen granules indicative of true acinar differentiation. The only paediatric case was an unencapsulated tumour composed of macrocystic structures covered by a mostly single but, focally, double layer of cells with apocrine morphology. In all cases, the neoplastic cells revealed immunoreactivity for S100, mammaglobin, cytokeratin CK7, CK8, STAT5a and vimentin. FISH for ETV6 gene rearrangement was positive in six out of seven cases, and RT-PCR was positive in three cases. MASC is a new entity of malignant epithelial salivary gland tumours not included in the 2005 WHO Classification of Head and Neck Tumours. There is a growing body of evidence that it is not as rare as was assumed, as is also indicated by our series (3.8 %). In most cases, MASC shares some microscopic features with AciCC, adenocarcinoma/cystadenocarcinoma NOS and low-grade MEC. In rare cases, MASC with high-grade transformation may mimic the morphological appearances of high-grade salivary gland malignancies, such as salivary duct carcinoma.

  20. ETV6 rearrangement in a case of mammary analogue secretory carcinoma of the skin.

    Science.gov (United States)

    Chang, Michael D; Arthur, Allison K; García, Joaquín J; Sukov, William R; Shon, Wonwoo

    2016-11-01

    Mammary analog secretory carcinoma of salivary glands is a relatively recently recognized entity that harbors the ETV6-NTRK3 fusion transcript. To date, only rare cases of mammary analog secretory carcinoma of the skin have been reported. A 57-year-old man presented with a 6.0 cm cystic mass in the axilla, involving the dermis and superficial subcutis. Microscopically, the tumor exhibited nodular aggregation of tubular and microcystic structures embedded in the dense fibrotic and hyalinized stroma. Characteristic 'colloid-like' eosinophilic secretory material was present within intraluminal spaces. Tumor cells were largely characterized by vesicular nuclei with inconspicuous nucleoli and pink vacuolated cytoplasm. With respect to immunohistochemistry, tumor cells were intensely positive for AE1/AE3, Cam 5.2, and CK7, whereas Ber-EP4 and CEA were completely negative. A dual color break-apart fluorescence in situ hybridization probe identified rearrangement of the ETV6 gene locus on chromosome 12. The patient is alive with no evidence of recurrent disease or metastasis 3 years after the initial surgery. In conclusion, we report a rare example of mammary analog secretory carcinoma of the skin with ETV6 rearrangement. Awareness of this unique cutaneous tumor and subsequent reporting of additional cases is necessary for better characterization of its completely clinicopathologic spectrum. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  1. Outcome of ETV6/RUNX1-positive childhood acute lymphoblastic leukaemia in the NOPHO-ALL-1992 protocol: frequent late relapses but good overall survival

    DEFF Research Database (Denmark)

    Forestier, E.; Heyman, M.; Andersen, Mette Klarskov

    2008-01-01

    The prognostic impact of t(12;21)(p13;q22) [ETV6/RUNX1 fusion] in paediatric acute lymphoblastic leukaemia (ALL) has been extensively debated, particularly with regard to the frequency of late relapses and appropriate treatment regimens. We have retrospectively collected 679 ALLs with known ETV6/...

  2. A Missense Mutation in the Transcription Factor ETV5 Leads to Sterility, Increased Embryonic and Perinatal Death, Postnatal Growth Restriction, Renal Asymmetry and Polydactyly in the Mouse

    Science.gov (United States)

    Jamsai, Duangporn; Clark, Brett J.; Smith, Stephanie J.; Whittle, Belinda; Goodnow, Christopher C.; Ormandy, Christopher J.; O’Bryan, Moira K.

    2013-01-01

    ETV5 (Ets variant gene 5) is a transcription factor that is required for fertility. In this study, we demonstrate that ETV5 plays additional roles in embryonic and postnatal developmental processes in the mouse. Through a genome-wide mouse mutagenesis approach, we generated a sterile mouse line that carried a nonsense mutation in exon 12 of the Etv5 gene. The mutation led to the conversion of lysine at position 412 into a premature termination codon (PTC) within the ETS DNA binding domain of the protein. We showed that the PTC-containing allele produced a highly unstable mRNA, which in turn resulted in an undetectable level of ETV5 protein. The Etv5 mutation resulted in male and female sterility as determined by breeding experiments. Mutant males were sterile due to a progressive loss of spermatogonia, which ultimately resulted in a Sertoli cell only phenotype by 8 week-of-age. Further, the ETV5 target genes Cxcr4 and Ccl9 were significantly down-regulated in mutant neonate testes. CXCR4 and CCL9 have been implicated in the maintenance and migration of spermatogonia, respectively. Moreover, the Etv5 mutation resulted in several developmental abnormalities including an increased incidence of embryonic and perinatal lethality, postnatal growth restriction, polydactyly and renal asymmetry. Thus, our data define a physiological role for ETV5 in many aspects of development including embryonic and perinatal survival, postnatal growth, limb patterning, kidney development and fertility. PMID:24204802

  3. A missense mutation in the transcription factor ETV5 leads to sterility, increased embryonic and perinatal death, postnatal growth restriction, renal asymmetry and polydactyly in the mouse.

    Science.gov (United States)

    Jamsai, Duangporn; Clark, Brett J; Smith, Stephanie J; Whittle, Belinda; Goodnow, Christopher C; Ormandy, Christopher J; O'Bryan, Moira K

    2013-01-01

    ETV5 (Ets variant gene 5) is a transcription factor that is required for fertility. In this study, we demonstrate that ETV5 plays additional roles in embryonic and postnatal developmental processes in the mouse. Through a genome-wide mouse mutagenesis approach, we generated a sterile mouse line that carried a nonsense mutation in exon 12 of the Etv5 gene. The mutation led to the conversion of lysine at position 412 into a premature termination codon (PTC) within the ETS DNA binding domain of the protein. We showed that the PTC-containing allele produced a highly unstable mRNA, which in turn resulted in an undetectable level of ETV5 protein. The Etv5 mutation resulted in male and female sterility as determined by breeding experiments. Mutant males were sterile due to a progressive loss of spermatogonia, which ultimately resulted in a Sertoli cell only phenotype by 8 week-of-age. Further, the ETV5 target genes Cxcr4 and Ccl9 were significantly down-regulated in mutant neonate testes. CXCR4 and CCL9 have been implicated in the maintenance and migration of spermatogonia, respectively. Moreover, the Etv5 mutation resulted in several developmental abnormalities including an increased incidence of embryonic and perinatal lethality, postnatal growth restriction, polydactyly and renal asymmetry. Thus, our data define a physiological role for ETV5 in many aspects of development including embryonic and perinatal survival, postnatal growth, limb patterning, kidney development and fertility.

  4. Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia

    Science.gov (United States)

    Ellinghaus, E; Stanulla, M; Richter, G; Ellinghaus, D; te Kronnie, G; Cario, G; Cazzaniga, G; Horstmann, M; Panzer Grümayer, R; Cavé, H; Trka, J; Cinek, O; Teigler-Schlegel, A; ElSharawy, A; Häsler, R; Nebel, A; Meissner, B; Bartram, T; Lescai, F; Franceschi, C; Giordan, M; Nürnberg, P; Heinzow, B; Zimmermann, M; Schreiber, S; Schrappe, M; Franke, A

    2012-01-01

    Acute lymphoblastic leukemia (ALL) is a malignant disease of the white blood cells. The etiology of ALL is believed to be multifactorial and likely to involve an interplay of environmental and genetic variables. We performed a genome-wide association study of 355 750 single-nucleotide polymorphisms (SNPs) in 474 controls and 419 childhood ALL cases characterized by a t(12;21)(p13;q22) — the most common chromosomal translocation observed in childhood ALL — which leads to an ETV6–RUNX1 gene fusion. The eight most strongly associated SNPs were followed-up in 951 ETV6-RUNX1-positive cases and 3061 controls from Germany/Austria and Italy, respectively. We identified a novel, genome-wide significant risk locus at 3q28 (TP63, rs17505102, PCMH=8.94 × 10−9, OR=0.65). The separate analysis of the combined German/Austrian sample only, revealed additional genome-wide significant associations at 11q11 (OR8U8, rs1945213, P=9.14 × 10−11, OR=0.69) and 8p21.3 (near INTS10, rs920590, P=6.12 × 10−9, OR=1.36). These associations and another association at 11p11.2 (PTPRJ, rs3942852, P=4.95 × 10−7, OR=0.72) remained significant in the German/Austrian replication panel after correction for multiple testing. Our findings demonstrate that germline genetic variation can specifically contribute to the risk of ETV6–RUNX1-positive childhood ALL. The identification of TP63 and PTPRJ as susceptibility genes emphasize the role of the TP53 gene family and the importance of proteins regulating cellular processes in connection with tumorigenesis. PMID:22076464

  5. Interaction of the androgen receptor, ETV1 and PTEN pathways in mouse prostate varies with pathological stage and predicts cancer progression

    Science.gov (United States)

    Higgins, Jake; Brogley, Michele; Palanisamy, Nallasivam; Mehra, Rohit; Ittmann, Michael M.; Li, Jun Z.; Tomlins, Scott A.; Robins, Diane M.

    2015-01-01

    To examine the impact of common somatic mutations in prostate cancer (PCa) on androgen receptor (AR) signaling, mouse models were designed to perturb sequentially the AR, ETV1 and PTEN pathways. Mice with "humanized" AR (hAR) alleles that modified AR transcriptional strength by varying polyglutamine tract (Q-tract) length were crossed with mice expressing a prostate-specific, AR-responsive ETV1 transgene (ETV1Tg). While hAR allele did not grossly affect ETV1-induced neoplasia, ETV1 strongly antagonized global AR regulation and repressed critical androgen-induced differentiation and tumor suppressor genes, such as Nkx3-1 and Hoxb13. When Pten was varied to determine its impact on disease progression, mice lacking one Pten allele (Pten+/−) developed more frequent prostatic intraepithelial neoplasia (PIN). Yet only those with the ETV1 transgene progressed to invasive adenocarcinoma. Furthermore, progression was more frequent with the short Q-tract (stronger) AR, suggesting that the AR, ETV1 and PTEN pathways cooperate in aggressive disease. On the Pten+/− background, ETV1 had markedly less effect on AR target genes. However, a strong inflammatory gene expression signature, notably upregulation of Cxcl16, was induced by ETV1. Comparison of mouse and human patient data stratified by presence of ETS fusion genes highlighted additional factors, some not previously associated with prostate cancer but for which targeted therapies are in development for other diseases. In sum, concerted use of these mouse models illuminates the complex interplay of AR, ETV1 and PTEN pathways in pre-cancerous neoplasia and early tumorigenesis, disease stages difficult to analyze in man. PMID:25631336

  6. LAM add-on ADV combination therapy or ETV monotherapy for CHB patients with suboptimal response to ADV.

    Science.gov (United States)

    Jia, Hongyu; Ding, Feng; Chen, Jianyang; Zhang, Yimin; Xiang, Dairong; Lian, Jiangshan; Zeng, Linyan; Yu, Liang; Hu, Jianhua; Li, Yongtao; Lu, Yingfeng; Liu, Yuanchun; Zheng, Lin; Li, Lanjuan; Yang, Yida

    2015-01-01

    Among the available nucleos(t)ide analogues adefovir dipivoxil (ADV) is relatively cheap and widely used in rural area in China. However, there are insufficient data on recommendation for patients with suboptimal response to ADV after 48 weeks of treatment in order to reduce the resistance rate in the long term. The aim of this study was to compare the efficacy and safety of LAM add-on combination therapy versus ETV monotherapy for patients with suboptimal response to ADV. 136 patients with suboptimal response to ADV were randomly assigned to the add-on LAM with ADV combination therapy (68 patients) group and the ETV monotherapy (68 patients) group. Patients in the add-on group were prescribed 100 mg LAM and 10 mg ADV per day, while the monotherapy group received 0.5 mg ETV per day for 48 weeks. Tests for liver and kidney function, HBV serum markers, HBV DNA load, were performed every 3 months. The mean patient age in LAM add-on group and ETV monotherapy was 38.59 ± 7.65 and 37.56 ± 8.67 years respectively. The HBV DNA undetectable rate in the LAM add-on group and the ETV group were not significant difference at week 4, 12 and 24 (P > 0.05). However, the HBV undetectable rate in the ETV group was higher than that in the LAM add-on group at week 36 and 48 (P = 0.043 for week 36 and P = 0.038 for week 48). There was no significant difference both for HBeAg loss and HBeAg seroconversion between two groups (P > 0.05) at 48 weeks. Meanwhile, our study also demonstrated that the mean eGFR levels in LAM add-on group was decreased from 99.6 ± 8.71 at baseline to 86.4 ± 9.83 at the end of 48 weeks, which was significantly higher than that in the ETV monotherapy group (P add-on group experienced eGFR reduction by 20-30% from baseline at 48 weeks. No patients developed hyposphosphatemia in our study. Our study clearly showed that switch to ETV monotherapy was the more effective and more safe than that of LAM add-on combination therapy for patients with suboptimal response

  7. Genome‐wide analysis of cytogenetic aberrations in ETV6/RUNX1‐positive childhood acute lymphoblastic leukaemia

    DEFF Research Database (Denmark)

    Borst, Louise; Wesolowska, Agata; Joshi, Tejal

    2012-01-01

    The chromosomal translocation t(12;21) resulting in the ETV6/RUNX1 fusion gene is the most frequent structural cytogenetic abnormality among patients with childhood acute lymphoblastic leukaemia (ALL). We investigated 62 ETV6/RUNX1‐positive childhood ALL patients by single nucleotide polymorphism...... array to explore acquired copy number alterations (CNAs) at diagnosis. The mean number of CNAs was 2·82 (range 0–14). Concordance with available G‐band karyotyping and comparative genomic hybridization was 93%. Based on three major protein‐protein complexes disrupted by these CNAs, patients could...

  8. THE PEACE CORPS EDUCATIONAL TELEVISION (ETV) PROJECT IN COLOMBIA--TWO YEARS OF RESEARCH. RESEARCH REPORT NO. 4, THE COLOMBIAN TEACHER AND THE UTILIZATION VOLUNTEER--MAKING ETV WORK IN THE SCHOOLS OF A DEVELOPING COUNTRY.

    Science.gov (United States)

    COMSTOCK, GEORGE; MACCOBY, NATHAN

    TO FOCUS ON THE DAILY USE OF ETV IN COLOMBIAN SCHOOLS AND ON THE IMPACT OF THE PEACE CORPS UTILIZATION VOLUNTEERS WHO PROMOTED THE EFFECTIVE USE OF TV, SEVERAL SURVEYS WERE CONDUCTED WITH COLOMBIAN TEACHERS DURING 1964-65, THE LARGEST WITH 1,884 TEACHERS AT THE END OF THE SECOND SEMESTER IN 1965. IT WAS FOUND THAT NON-TEACHING PROBLEMS CONSISTUTED…

  9. Blastic plasmacytoid dendritic cell neoplasm with leukemic manifestation and ETV6 gene rearrangement: A case report.

    Science.gov (United States)

    Gao, N A; Wang, Xue-Xia; Sun, Jian-Rong; Yu, Wen-Zheng; Guo, Nong-Jian

    2015-04-01

    Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare malignant tumor of the hemopoietic system that arises from plasmacytoid dendritic cell precursors with a highly aggressive course. BPDCN frequently involves the skin, lymph nodes, peripheral blood and bone marrow. BPDCN is known to develop leukemic dissemination as a feature of myelomonocytic leukemia in the late phase of the disease, which leads to a poorer prognosis. In the present study, a case of BPDCN with leukemic manifestation without cutaneous involvement was reported. In addition, ETS variant gene 6 (ETV6) gene rearrangement was detected in the patient. The patient relapsed soon after complete remisson and had no response to further treatment. To the best of our knowledge, this is the first reported case of BPDCN with ETV6 rearrangement. Following chemotherapy treatment, the patient suffered from severe headache in the complete remission stage; however, brain CT scans showed no significant abnormalities. Several lumbar punctures and intrathecal chemotherapy were performed, and the patient recovered gradually. Therefore, the patient was considered to suffer from central nervous system leukemia. In conclusion, implementation of lumbar punctures and preventive intrathecal chemotherapy are required in BPDCN patients with leukemic manifestation during the remission stage.

  10. Telelegend Leo Karpin : ETV uus juhtkond teeb vaid lammutustööd / Leo Karpin ; interv. Verni Leivak

    Index Scriptorium Estoniae

    Karpin, Leo, 1946-2014

    2004-01-01

    Pea 40 aastat Eesti Televisioonis töötanud telerežissöör oma teletöölt lahkumise põhjustest. Lisaks kommentaar "ETV juhatuse esimees Ilmar Raag, miks tunnustatud telemees Leo Karpin ametist vabastati?"

  11. DOE ETV-1 electric test vehicle. Phase III: performance testing and system evaluation. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Kurtz, D. W.

    1981-12-01

    The DOE ETV-1 represents the most advanced electric vehicle in operation today. Engineering tests have been conducted by the Jet Propulsion Laboratory in order to characterize its overall system performance and component efficiencies within the system environment. A dynamometer was used in order to minimize the ambient effects and large uncertainties present in track testing. Extensive test requirements have been defined and procedures were carefully controlled in order to maintain a high degree of credibility. Limited track testing was performed in order to corroborate the dynamometer results. Test results include an energy flow analysis through the major subsystems and incorporate and aerodynamic and rolling losses under cyclic and various steady speed conditions. A complete summary of the major output from all relevant dynamometer and track tests is also included as an appendix.

  12. Near-term electric test vehicle ETV-2. Phase II. Final report

    Energy Technology Data Exchange (ETDEWEB)

    1981-04-01

    A unique battery-powered passenger vehicle has been developed that provides a significant improvement over conventional electric vehicle performance, particularly during stop-and-go driving. The vehicle is unique in two major respects: (1) the power system incorporates a flywheel that stores energy during regenerative braking and makes possible the acceleration capability needed to keep up with traffic without reducing range to unacceptable values; and (2) lightweight plastic materials are used for the vehicle unibody to minimize weight and increase range. These features were analyzed and demonstrated in an electric test vehicle, ETV-2. Characteristics of this vehicle are summarized. Information is presented on: vehicle design, fabrication, safety testing, and performance testing; power system design and operation; flywheel; battery pack performance; and controls and electronic equipment. (LCL)

  13. Combined DOG1 and Mammaglobin Immunohistochemistry Is Comparable to ETV6-breakapart Analysis for Differentiating Between Papillary Cystic Variants of Acinic Cell Carcinoma and Mammary Analogue Secretory Carcinoma.

    Science.gov (United States)

    Said-Al-Naief, Nasser; Carlos, Roman; Vance, Gail H; Miller, Caroline; Edwards, Paul C

    2017-04-01

    We investigated the reliability of combined DOG1 and mammaglobin immunohistochemistry compared with ETV6 fluorescence in situ hybridization (FISH) in the assessment of salivary tumors previously diagnosed as acinic cell carcinoma (ACC). Ultrastructural features of cases reclassified as mammary analogue secretory carcinoma (MASC) were assessed by transmission electron microscopy (TEM). Immunohistochemical (IHC) reactivity to DOG1 and mammaglobin was validated against FISH targeting the ETV6 gene in all 14 cases. Three cases with papillary cystic histomorphology previously diagnosed as ACC were revised to MASC. TEM features of the ETV6 rearrangement-positive MASC cases showed large numbers of secretory granules with extrusion into the intercellular spaces, well-developed endoplasmic reticulum, lipid-laden vacuoles, well-formed microvilli, and large lining cystic spaces. Combined DOG1 and mammaglobin immunohistochemistry is comparable to ETV6 -breakapart analysis for differentiating between papillary cystic variants of ACC and MASC.

  14. AFSC/NMML/CCEP: Diet of Pacific harbor seals at Umpqua River, Oregon and Columbia River, Oregon/Washington during 1994 through 2005

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — From 1994 to 2005, The National Marine Mammal Laboratories' California Current Ecosystem Program (AFSC/NOAA) collected fecal samples at the Umpqua River, Oregon and...

  15. Analysis of high-purity germanium dioxide by ETV-ICP-AES with preliminary concentration of trace elements.

    Science.gov (United States)

    Medvedev, Nickolay S; Shaverina, Anastasiya V; Tsygankova, Alphiya R; Saprykin, Anatoly I

    2016-08-01

    The paper presents a combined technique of germanium dioxide analysis by inductively coupled plasma atomic emission spectrometry (ICP-AES) with preconcentration of trace elements by distilling off matrix and electrothermal (ETV) introduction of the trace elements concentrate into the ICP. Evaluation of metrological characteristics of the developed technique of high-purity germanium dioxide analysis was performed. The limits of detection (LODs) for 25 trace elements ranged from 0.05 to 20ng/g. The accuracy of proposed technique is confirmed by "added-found" («or spiking») experiment and comparing the results of ETV-ICP-AES and ICP-AES analysis of high purity germanium dioxide samples. Copyright © 2016 Elsevier B.V. All rights reserved.

  16. Mammary analog secretory carcinoma of the thyroid gland: A primary thyroid adenocarcinoma harboring ETV6–NTRK3 fusion

    Science.gov (United States)

    Dogan, Snjezana; Wang, Lu; Ptashkin, Ryan N; Dawson, Robert R; Shah, Jatin P; Sherman, Eric J; Tuttle, R Michael; Fagin, James A; Klimstra, David S; Katabi, Nora; Ghossein, Ronald A

    2016-01-01

    ETV6–NTRK3 fusion was identified in several cancers including the recently described mammary analog secretory carcinoma (MASC) of the salivary glands and a minority of papillary thyroid carcinomas. We describe three cases of primary MASC of the thyroid gland and provide a detailed clinical and pathological characterization of the tumor morphology, immunoprofile, and genetic background. Immunohistochemistry for PAX8, TTF-1, thyroglobulin, mammaglobin, GCDFP-15, S-100 protein, and p63 was used to define the tumor immunophenotype. Fluorescence in situ hybridization for ETV6 rearrangement was performed in three, and the next-generation sequencing assay MSK-IMPACT™ (Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets) was performed in two cases. Primary MASC of the thyroid occurred in two women and one man, age 47–72 years. All patients presented with high T stage, infiltrative, locally aggressive tumors with extrathyroidal extension. Two cases were associated with well-differentiated papillary thyroid carcinoma. Histologically, they appeared as low-grade tumors, resembling MASC of the salivary glands and labeled positive for mammaglobin, GCDFP-15, S-100 protein, p63, weakly positive for PAX8, and negative for TTF-1 and thyroglobulin. Fluorescence in situ hybridization revealed ETV6 rearrangement in all cases. In two tested cases MSK-IMPACT™ confirmed the presence of ETV6–NTRK3 gene fusion. Two patients had at least two local recurrences, one was alive with disease, and one was alive and free of disease after 14 and 17 years, respectively. The third patient was alive and free of disease after 2 years. MASC of the thyroid is histologically, immunophenotypically, and genetically similar to its salivary gland counterpart. Thyroid MASC can be associated with a well-differentiated papillary thyroid carcinoma component, supporting follicular cell origin. Clinically, these carcinomas may show frequent recurrences but are associated

  17. [Environmental Hazards Assessment Program annual report, June 1992--June 1993]. South Carolina ETV Socratic Dialog II

    Energy Technology Data Exchange (ETDEWEB)

    1993-06-01

    This report contains the script from a videotaped dialogue concerning a hypothetical hazardous waste/community health risk scenario presented as a Round Table Forum. Various issues are explored, ranging from the scientific and technical aspects of environmental studies and remedial action, to public information and community involvement, to the economic impact on local communities. The roles of the media, local government and federal and state agencies are examined as well as sources for funding. In an attempt to gauge audience response and reaction, evaluation cards were distributed, and the comments and recommendations are included here.

  18. The ERK MAP kinase-PEA3/ETV4-MMP-1 axis is operative in oesophageal adenocarcinoma

    LENUS (Irish Health Repository)

    Keld, Richard

    2010-12-09

    Abstract Background Many members of the ETS-domain transcription factor family are important drivers of tumourigenesis. In this context, their activation by Ras-ERK pathway signaling is particularly relevant to the tumourigenic properties of many ETS-domain transcription factors. The PEA3 subfamily of ETS-domain transcription factors have been implicated in tumour metastasis in several different cancers. Results Here, we have studied the expression of the PEA3 subfamily members PEA3\\/ETV4 and ER81\\/ETV1 in oesophageal adenocarcinomas and determined their role in oesophageal adenocarcinoma cell function. PEA3 plays an important role in controlling both the proliferation and invasive properties of OE33 oesophageal adenocarcinoma cells. A key target gene is MMP-1. The ERK MAP kinase pathway activates PEA3 subfamily members and also plays a role in these PEA3 controlled events, establishing the ERK-PEA3-MMP-1 axis as important in OE33 cells. PEA3 subfamily members are upregulated in human adenocarcinomas and expression correlates with MMP-1 expression and late stage metastatic disease. Enhanced ERK signaling is also more prevalent in late stage oesophageal adenocarcinomas. Conclusions This study shows that the ERK-PEA3-MMP-1 axis is upregulated in oesophageal adenocarcinoma cells and is a potentially important driver of the metastatic progression of oesophageal adenocarcinomas.

  19. Improving the Effectiveness of Peace Corps Efforts to Change Teacher Behavior. The Peace Corps Educational Television (ETV) Project in Colombia: Two Years of Research.

    Science.gov (United States)

    Comstock, George; Maccoby, Nathan

    For a report on a two-year Peace Corps project designed to implement educational television (ETV) in Colombia, the persuasive and defense arousal effects of several kinds of appeals that might be used to persuade Colombian teachers to adopt new teaching practices were investigated. Subjects, who were 100 Colombian public primary school teachers…

  20. THE PEACE CORPS EDUCATIONAL TELEVISION (ETV) PROJECT IN COLOMBIA--TWO YEARS OF RESEARCH. RESEARCH REPORT NO. 8, THE TELEVISED CURRICULUM AND THE COLOMBIAN TEACHER.

    Science.gov (United States)

    COMSTOCK, GEORGE; MACCOBY, NATHAN

    DATA FROM SURVEYS OF COLOMBIAN TEACHERS' OPINIONS OF THE PEACE CORPS ETV PROJECT SHOWED THAT ALTHOUGH THE TEACHERS WERE GENERALLY PLEASED, THEY FELT THERE WAS MUCH ROOM FOR IMPROVEMENT IN THE CURRICULUM AND THE TEACHER GUIDES. AFTER EACH OF FOUR SEMESTERS, QUESTIONNAIRES WERE GIVEN TO TEACHERS WHO HAD ACTUALLY USED TELEVISED COURSES IN THEIR…

  1. Downregulation of vertebrate Tel (ETV6) and Drosophila Yan is facilitated by an evolutionary conserved mechanism of F-box-mediated ubiquitination

    NARCIS (Netherlands)

    M.G. Roukens (Guy); M. Alloul-Ramdhani (Mariam); S. Moghadasi (Setareh); M. Op den Brouw (Marjolein); D.A. Baker (David)

    2008-01-01

    textabstractThe vertebrate Ets transcriptional repressor Tel (ETV6) and its invertebrate orthologue, Yan, are both indispensable for development, and they orchestrate cell growth and differentiation by binding to DNA, thus inhibiting gene expression. To trigger cell differentiation, these barriers

  2. RT-PCR Screening for ETV6-RUNX1-positive Clones in Cord Blood From Newborns in the Danish National Birth Cohort

    DEFF Research Database (Denmark)

    Olsen, Marianne; Hjalgrim, Henrik; Melbye, Mads

    2012-01-01

    BACKGROUND:: Several large biobanks comprising umbilical cord blood samples have been established allowing efforts to characterize the prevalence and risk factors for preleukemic cell clones in healthy newborns. This study explores the feasibility of demonstrating translocation ETV6-RUNX1 transcr...

  3. Gynecologic evaluation of the first female soldiers enrolled in the Gulf War Comprehensive Clinical Evaluation Program at Tripler Army Medical Center.

    Science.gov (United States)

    Wittich, A C

    1996-11-01

    Tripler Army Medical Center initiated the Department of Defense's Persian Gulf Illness Comprehensive Clinical Evaluation Program (CCEP) on June 15, 1994. In the first 5 months, 100 patients enrolled in this program. Sixteen (16%) were women who served in the Persian Gulf during Desert Shield/ Desert Storm, and 1 (1%) was the dependent wife of a Gulf War veteran who is experiencing illness that may be related to the Persian Gulf War. All 17 women enrolled in the CCEP were evaluated in the Tripler Army Medical Center Obstetrics and Gynecology Clinic between June 17 and November 10, 1994. Each patient underwent gynecologic history, pelvic exam, Pap smear, and screen for fecal occult blood. Ten patients underwent baseline mammograms and 13 patients underwent urogenital and cervical cultures for aerobic bacteria, chlamydia and herpes simplex. The 1 patient with an abnormal Pap smear underwent cervical and endocervical biopsies and colposcopy (histology demonstrated no dysplasia or neoplasia). Half of the 16 Gulf War veterans experienced gynecologic problems while serving in the Gulf and 43% admitted gynecologic problems since returning in 1991. Of 6 patients who became pregnant after returning, 5 had normal pregnancies and 1 suffered four miscarriages.

  4. The Evolution of Improved Baghouse Filter Media as Observed in the Environmental Technology Verification Program

    Science.gov (United States)

    The U.S. EPA implemented the Environmental Technology Verification (ETV) program in 1995 to generate independent and credible data on the performance of innovative technologies that have the potential to improve protection of public health and the environment. Results are publicl...

  5. Infantile Fibrosarcoma With NTRK3-ETV6 Fusion Successfully Treated With the Tropomyosin-Related Kinase Inhibitor LOXO-101.

    Science.gov (United States)

    Nagasubramanian, Ramamoorthy; Wei, Julie; Gordon, Paul; Rastatter, Jeff C; Cox, Michael C; Pappo, Alberto

    2016-08-01

    Infantile fibrosarcoma (IFS) is a rare pediatric cancer typically presenting in the first 2 years of life. Surgical resection is usually curative and chemotherapy is active against gross residual disease. However, when recurrences occur, therapeutic options are limited. We report a case of refractory IFS with constitutive activation of the tropomyosin-related kinase (TRK) signaling pathway from an ETS variant gene 6-neurotrophin 3 receptor gene (ETV6-NTRK3) gene fusion. The patient enrolled in a pediatric Phase 1 trial of LOXO-101, an experimental, highly selective inhibitor of TRK. The patient experienced a rapid, radiographic response, demonstrating the potential for LOXO-101 to provide benefit for IFS harboring NTRK gene fusions. © 2016 The Authors. Pediatric Blood & Cancer, published by Wiley Periodicals, Inc.

  6. Two obesity susceptibility loci in LYPLAL1 and ETV5 independently associated with childhood hypertension in Chinese population.

    Science.gov (United States)

    Lv, Duo; Zhou, Dan; Zhang, Yan; Zhang, Shuai; Zhu, Yi-Min

    2017-09-05

    Genome-wide association studies have identified novel obesity-associated susceptibility loci. Associations of these variants with childhood obesity have been studied in our previous research. The purpose of this study is to investigate if these loci are associated with hypertension being independent of obesity in Chinese children and adolescents. Nineteen candidate SNPs were genotyped using Sequenom MassARRAY platform among Chinese children (N=2954, 514 hypertension and 2440 controls, aged 7-17years). Dietary behaviors were assessed through face to face investigations. Of the nineteen obese related SNPs, ten SNPs were found to be associated with systolic blood pressure (SBP) or diastolic blood pressure (DBP) in Chinese children. After adjusting for age, sex and WHtR, rs2605100 in LYPLAL1was found to be associated with high blood pressure (HBP) under dominant model (P=0.024) with the OR of 1.274 (95% CI =1.033-1.572, effect genotype=GG). The distribution of genotype of rs7647305 in ETV5 showed significant difference between HBP and non-HBP subjects under dominant model (P=0.011) with the OR of 0.654 (95% CI=0.471-0.909, effect genotype=CC). Using rs2605100 and rs7647305, the genetic risk score (GRS) analysis showed that, after adjusted for age, sex and WHtR, subjects carrying one or two risk alleles had the risks of hypertension with the ORs 1.797 (95% CI, 1.168-2.765), 2.149 (95% CI, 1.375-3.357) comparing with the subjects with non-risk-allele. Genetic variations of obesity-associated loci, LYPLAL1 rs2605100 and ETV5 rs7647305 independently associate with the risk of childhood hypertension in China. Copyright © 2017 Elsevier B.V. All rights reserved.

  7. Characterization of the near-term electric vehicle (ETV-1) breadboard propulsion system over the SAE J227a driving schedule D

    Science.gov (United States)

    Sargent, N. B.; Dustin, M. O.

    1981-01-01

    The electric test vehicle one (ETV-1) was built from the ground up with present state of the art technology. Two vehicles were built and are presently being evaluated by NASA's Jet Propulsion Laboratory (JPL). A duplicate set of propulsion system components was built, mounted on a breadboard, and delivered to NASA's Lewis Research Center for testing on the road load simulator (RLS). Driving cycle tests completed on the system are described.

  8. Frequency and clinical impact of ETV6/RUNX1, AF4-MLL, and BCR/ABL fusion genes on features of acute lymphoblastic leukemia at presentation.

    Science.gov (United States)

    Ajuba, I C; Madu, A J; Okocha, C; Ibegbulam, O G; Okpala, I; Nna, O E

    2016-01-01

    Variations in disease presentation and outcome of leukemia treatment has been associated with the presence of certain mutant genes. Three major translocations (ETV6-RUNX1, BCR-ABL, and AF4-MLL) in acute lymphoblastic leukemia (ALL) have been shown to affect treatment outcome. This study is aimed at assessing the relationship between these translocations and the presence of other indicators of disease severity (white cell count, hemoglobin concentration, platelet count, and hematocrit) in ALL. Forty chemotherapy naïve patients aged between 9 months and 54 years had their marrow samples analyzed for the prevalent mutations. Their clinical and laboratory details on presentation were also obtained. Abnormal genes detected were BCR/ABL1 major transcript in 5 (12.5%), ETV6/RUNX1 in 2 (5.0%), MLL/AF4 none and none of the patients had more than one fusion gene. There was no relationship between the presence of these fusion genes and the clinical and laboratory features of ALL. An association exists between the fusion genes and ethnic origin of the patients (P = 0.005). There is no significant association between the abnormal fusion genes detected and some laboratory features of prognostic importance, which include total white blood cell count (P = 0.416) and FAB subtype (P = 0.576). Presence of fusion the genes BCR/ABL1, ETV6/RUNX1, and MLL/AF4 does not have any impact on the clinical and laboratory features of ALL at presentation.

  9. Characterization of mammary analogue secretory carcinoma of the salivary gland: discrimination from its mimics by the presence of the ETV6-NTRK3 translocation and novel surrogate markers.

    Science.gov (United States)

    Urano, Makoto; Nagao, Toshitaka; Miyabe, Satoru; Ishibashi, Kenichiro; Higuchi, Kayoko; Kuroda, Makoto

    2015-01-01

    Mammary analogue secretory carcinoma (MASC) is a recently recognized salivary gland tumor harboring an ETV6-NTRK3 translocation similar to secretory carcinoma of the breast. Histologically, MASC mimics papillary-cystic, microcystic, and follicular-type acinic cell carcinoma (AciCC) and low-grade cribriform cystadenocarcinoma (LGCCC) of the salivary gland. Using histology, immunohistochemistry (IHC), and molecular genetic techniques, we reevaluated 18 cases originally diagnosed as AciCC between 1993 and 2012. The last of these methods was used to detect the ETV6-NTRK3 translocation. The results reconfirmed 6 cases as AciCC (3 men; average age, 63 years) and helped us reclassify 10 cases as MASC (6 men; mean age, 46 years) and 2 as LGCCC (2 women; mean age, 48 years). Using IHC, we identified the 3 histologic types according to the expression patterns of vimentin, high-molecular-weight cytokeratin, cytokeratin 19, S-100, mammaglobin, MUC1, GATA-binding protein 3, adipophilin, α-amylase, DOG-1, SOX-10, and p63. The number of tumors diagnosed as MASC indicates that AciCC includes bona fide MASC cases. Because differential diagnosis among zymogen granule-poor AciCC, MASC, and LGCCC tumors is challenging, we recommend using molecular genetic tests for ETV6-NTRK3 for accurate diagnosis. Furthermore, detailed analyses of hematoxylin and eosin-stained tissues and IHC studies using the markers described here should be incorporated into routine practices. Copyright © 2014 Elsevier Inc. All rights reserved.

  10. Minimal residual disease monitoring in childhood B lymphoblastic leukemia with t(12;21)(p13;q22); ETV6-RUNX1: concordant results using quantitation of fusion transcript and flow cytometry.

    Science.gov (United States)

    Alm, S J; Engvall, C; Asp, J; Palmqvist, L; Abrahamsson, J; Fogelstrand, L

    2017-04-01

    The translocation t(12;21)(p13;q22) resulting in the fusion gene ETV6-RUNX1, is the most frequent gene fusion in childhood B lymphoblastic leukemia. In the Nordic Society of Paediatric Haematology and Oncology ALL-2008 treatment protocol, treatment stratification in B-lineage ALL is based on results of minimal residual disease (MRD) analysis with fluorescence-activated cell sorting (FACS). In this study, we determined whether RT-qPCR of the ETV6-RUNX1 fusion transcript can be a reliable alternative for MRD analysis. Seventy-eight bone marrow samples from 29 children at diagnosis and day 15, 29, and 78 during treatment were analyzed for MRD with FACS and with quantitative reverse transcription polymerase chain reaction (RT-qPCR). Fusion transcript MRD was defined as the ETV6-RUNX1/GUSB ratio at the follow-up time point (day 15/29/78) divided with the ETV6-RUNX1/GUSB ratio at diagnosis (%). MRD analysis with FACS and with RT-qPCR of ETV6-RUNX1 fusion transcript showed strong correlation. All cases showed concordant results at the treatment stratifying time points day 29 and day 78, when comparing the two methods with a cutoff set to 0.1%. RT-qPCR is a valuable addition and could also be an alternative to FACS in cases where FACS is not achievable for MRD analysis. © 2016 John Wiley & Sons Ltd.

  11. Embryonic Stem Cell Differentiation to Functional Arterial Endothelial Cells through Sequential Activation of ETV2 and NOTCH1 Signaling by HIF1α

    Directory of Open Access Journals (Sweden)

    Kit Man Tsang

    2017-09-01

    Full Text Available The generation of functional arterial endothelial cells (aECs from embryonic stem cells (ESCs holds great promise for vascular tissue engineering. However, the mechanisms underlying their generation and the potential of aECs in revascularizing ischemic tissue are not fully understood. Here, we observed that hypoxia exposure of mouse ESCs induced an initial phase of HIF1α-mediated upregulation of the transcription factor Etv2, which in turn induced the commitment to the EC fate. However, sustained activation of HIF1α in these EC progenitors thereafter induced NOTCH1 signaling that promoted the transition to aEC fate. We observed that transplantation of aECs mediated arteriogenesis in the mouse hindlimb ischemia model. Furthermore, transplantation of aECs in mice showed engraftment in ischemic myocardium and restored cardiac function in contrast to ECs derived under normoxia. Thus, HIF1α activation of Etv2 in ESCs followed by NOTCH1 signaling is required for the generation aECs that are capable of arteriogenesis and revascularization of ischemic tissue.

  12. Chronic eosinophilic leukemia, NOS with t(5;12(q31;p13/ETV6-ACSL6 gene fusion: A novel variant of myeloid proliferative neoplasm with eosinophilia

    Directory of Open Access Journals (Sweden)

    Ruijun Jeanna Su

    2016-09-01

    Full Text Available The 2008 World Health Organization (WHO classification of tumors of hematopoietic and lymphoid tissues introduced a category for myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB or FGFR1. Many of these patients are responsive to tyrosine kinase inhibitor (TKI therapy. In this case report, we report a unique case of chronic eosinophilic leukemia with novel t(5;12(q23-31;p13/ETV6-ACSL6 gene fusion, in which patient was resistant to TKI therapy. This important finding is a novel addition to the above entity in WHO 2008 classification. The ACSL6 gene encodes a long-chain acyl-CoA synthetase, an enzyme that plays an essential role in lipid metabolism and ATP generation pathways in cells. The ETV6-ACSL6 rearrangement is present in diverse types of hematopoietic malignancies. As yet, it is not clear how ACSL6, a gene involved in fatty acid synthesis, contributes to clonal expansion of myeloid progenitor cells. Therefore, elucidating the contribution of ACSL6 to leukemogenesis may allow the development of novel treatment for those resistant to TKI therapy.

  13. THE PEACE CORPS EDUCATIONAL TELEVISION (ETV) PROJECT IN COLOMBIA--TWO YEARS OF RESEARCH. RESEARCH REPORT NO. 2, THE PROJECT'S FIRST SEMESTER--PUPIL ACHIEVEMENT, TEACHER ATTITUDES, AND THE WORK OF THE UTILIZATION VOLUNTEER.

    Science.gov (United States)

    COMSTOCK, GEORGE; MACCOBY, NATHAN

    THE PEACE CORPS (ETV) PROJECT IN COLOMBIA ENCOUNTERED PROBLEMS IN TV PRODUCTION, INSTALLATION, MAINTENANCE, UTILIZATION OF TELEVISED INSTRUCTION, AND LEADERSHIP. BY JUNE OF THE FIRST SEMESTER TELEVISED ELEMENTARY INSTRUCTION INCLUDED ABOUT 390 SCHOOLS, 2,000 TEACHERS, AND 60,000 PUIPLS. EXTENSIVE RESEARCH INTENDED TO PROVIDE A BASIS FOR CORRECTIVE…

  14. Mammary analogue secretory carcinoma of salivary glands with high-grade transformation: report of 3 cases with the ETV6-NTRK3 gene fusion and analysis of TP53, β-catenin, EGFR, and CCND1 genes.

    Science.gov (United States)

    Skálová, Alena; Vanecek, Tomas; Majewska, Hanna; Laco, Jan; Grossmann, Petr; Simpson, Roderick H W; Hauer, Lukas; Andrle, Pavel; Hosticka, Lubor; Branžovský, Jindrich; Michal, Michal

    2014-01-01

    Mammary analogue secretory carcinoma of salivary gland origin (MASC) is a recently described tumor resembling secretory carcinoma of the breast characterized by strong S-100 protein, mammaglobin, and vimentin immunoexpression and which harbors a t(12;15) (p13;q25) translocation resulting in ETV6-NTRK3 fusion product. Histologically, conventional MASC displays bland histomorphology and a lobulated growth pattern and is often composed of microcystic, tubular, and solid structures with abundant eosinophilic homogenous or bubbly secretions. Colloid-like secretory material stains positively for periodic acid-Schiff with and without diastase as well as for Alcian Blue. We present for the first time, 3 patients with MASC of the parotid gland in which high-grade (HG) transformation developed in each case characterized by an accelerated clinical course and poor outcome. The HG component revealed strong membrane staining for EGFR and β-catenin, cytoplasmic/nuclear staining for S-100 protein, and nuclear staining for cyclin-D1, whereas HER-2/neu was absent. Analysis for the presence of the ETV6-NTRK3 fusion transcript revealed positivity in both HG and low-grade component of MASC in 2 of the 3 studied cases. The tumor in case 2 was negative in both its elements for the t(12;15) translocation, but ETV6 gene rearrangement was detected in both components in all 3 cases. Analysis of TP53 and CTNNB1 gene mutations in the HG component of MASCs as well as detection of copy number aberration of EGFR and CCND1 gene did not harbor any abnormalities. All 3 patients with HG-transformed MASC died of disseminated disease within 2 to 6 years after diagnosis. Recognizing HG-transformed MASC and testing for ETV6 rearrangement may be of potential value in patient treatment, because the presence of the ETV6-NTRK3 translocation may represent a therapeutic target in MASC.

  15. E-TV

    DEFF Research Database (Denmark)

    Jensen, Ingelise

    2008-01-01

    Materialet er en serie dvd-udgivelser + en lærervejledning med forslag til, hvordan man kan arbejde med filmen, filmscript samt kopiark til elevernes arbejde. Et supplement til den daglige undervisning i engelsk, som gør formidlingen af fremmedsproget kultur levende for eleverne, samtidig med at ...

  16. Festivalifilmid ETV ekraanil

    Index Scriptorium Estoniae

    2007-01-01

    XXI Rahvusvaheline Pärnu filmifestival : Eesti Televisioon näitab 8.-14.07. eriprogrammi, kuhu on valitud filmid "Minu surm, mitte sinu" (Saksamaa-India 2006), "Valgevene õppetund" (Poola-Valgevene 2006), "Beslan - õigus elada" (Venemaa 2006), "Esimene rahu õppetund" (Iisrael 2006), "Õnne vaenlased" (Taani-Afganistan 2006), "Mu tütar on terrorist" (Norra 2006) ja "Lugu kehast" (Iisrael 2006)

  17. Frequency of the ETV6-RUNX1, BCR-ABL1, TCF3-PBX1, and MLL-AFF1 fusion genes in Guatemalan pediatric acute lymphoblastic leukemia patients and their ethnic associations.

    Science.gov (United States)

    Carranza, Claudia; Granados, Lilian; Morales, Oneida; Jo, Wendy; Villagran, Swuanny; Tinti, Damaris; Villegas, Mauricio; Antillón, Federico; Torselli, Silvana; Silva, Gabriel

    2013-06-01

    Fusion genes involved in acute lymphoblastic leukemia (ALL) occur mostly due to genetic and environmental factors, and only a limited number of studies have reported any ethnic influence. This study assesses whether an ethnic influence has an effect on the frequency of any of the four fusion genes: BCR-ABL1, ETV6-RUNX1, TCF3-PBX1, and MLL-AFF1 found in ALL. To study this ethnic influence, mononuclear cells were obtained from bone marrow samples from 143 patients with ALL. We performed RNA extraction and reverse transcription, then assessed the quality of the cDNA by amplifying the ABL1 control gene, and finally evaluated the presence of the four transcripts by multiplex polymerase chain reaction. We found 10 patients who had the BCR-ABL1 fusion gene (7%); 3 patients (2%) were TCF3-PBX1 positive; and 6 patients (4.5%) were ETV6-RUNX1 positive. The incidence of this last fusion gene is quite low when compared to the values reported in most countries. The low incidence of the ETV6-RUNX1 fusion gene found in Guatemala matches the incidence rates that have been reported in Spain and Indian Romani. Since it is known that an ethnic resemblance exists among these three populations, as shown by ancestral marker studies, the ALL data suggests an ethnic influence on the occurrence and frequency of this particular fusion gene. Copyright © 2013 Elsevier Inc. All rights reserved.

  18. Selection of the highly replicative and partially multidrug resistant rtS78T HBV polymerase mutation during TDF-ETV combination therapy.

    Science.gov (United States)

    Shirvani-Dastgerdi, Elham; Winer, Benjamin Y; Celià-Terrassa, Toni; Kang, Yibin; Tabernero, David; Yagmur, Eray; Rodríguez-Frías, Francisco; Gregori, Josep; Luedde, Tom; Trautwein, Christian; Ploss, Alexander; Tacke, Frank

    2017-08-01

    Patients chronically infected with the hepatitis B virus (HBV) and receiving long-term treatment with nucleoside or nucleotide analogues are at risk of selecting HBV strains with complex mutational patterns. We herein report two cases of HBV-infected patients with insufficient viral suppression, despite dual antiviral therapy with entecavir (ETV) and tenofovir (TDF). One patient died from aggressive hepatocellular carcinoma (HCC). Serum samples from the two patients at different time points were analyzed using ultra-deep pyrosequencing analysis. HBV mutations were identified and transiently transfected into hepatoma cells in vitro using replication-competent HBV vectors, and functionally analyzed. We assessed replication efficacy, resistance to antivirals and potential impact on HBV secretion (viral particles, exosomes). Sequencing analyses revealed the selection of the rtS78T HBV polymerase mutation in both cases that simultaneously creates a premature stop codon at sC69 and thereby deletes almost the entire small HBV surface protein. One of the patients had an additional 261bp deletion in the preS1/S2 region. Functional analyses of the mutations in vitro revealed that the rtS78T/sC69∗ mutation, but not the preS1/S2 deletion, significantly enhanced viral replication and conferred reduced susceptibility to ETV and TDF. The sC69∗ mutation caused truncation of HBs protein, leading to impaired detection by commercial HBsAg assay, without causing intracellular HBsAg retention or affecting HBV secretion. The rtS78T/sC69∗ HBV mutation, associated with enhanced replication and insufficient response to antiviral treatment, may favor long-term persistence of these isolates. In addition to the increased production of HBV transcripts and the sustained secretion of viral particles in the absence of antigenic domains of S protein, this HBV mutation may predispose patients to carcinogenic effects. Long-term treatment with antiviral drugs carries the risk of selecting

  19. Mammary analogue secretory carcinoma of salivary glands, containing the ETV6-NTRK3 fusion gene: a hitherto undescribed salivary gland tumor entity.

    Science.gov (United States)

    Skálová, Alena; Vanecek, Tomas; Sima, Radek; Laco, Jan; Weinreb, Ilan; Perez-Ordonez, Bayardo; Starek, Ivo; Geierova, Marie; Simpson, Roderrick H W; Passador-Santos, Fabricio; Ryska, Ales; Leivo, Ilmo; Kinkor, Zdenek; Michal, Michal

    2010-05-01

    We present a series of 16 salivary gland tumors with histomorphologic and immunohistochemical features reminiscent of secretory carcinoma of the breast. This is a hitherto undescribed and distinctive salivary gland neoplasm, with features resembling both salivary acinic cell carcinoma (AciCC) and low-grade cystadenocarcinoma, and displaying strong similarities to breast secretory carcinoma. Microscopically, the tumors have a lobulated growth pattern and are composed of microcystic and glandular spaces with abundant eosinophilic homogenous or bubbly secretory material positive for periodic acid-Schiff, mucicarmine, MUC1, MUC4, and mammaglobin. The neoplasms also show strong vimentin, S-100 protein, and STAT5a positivity. For this tumor, we propose a designation mammary analogue secretory carcinoma of salivary glands (MASC). The 16 patients comprised 9 men and 7 women, with a mean age of 46 years (range 21 to 75). Thirteen cases occurred in the parotid gland, and one each in the minor salivary glands of the buccal mucosa, upper lip, and palate. The mean size of the tumors was 2.1 cm (range 0.7 to 5.5 cm). The duration of symptoms was recorded in 11 cases and ranged from 2 months to 30 years. Clinical follow-up was available in 13 cases, and ranged from 3 months to 10 years. Four patients suffered local recurrences. Two patients died, 1 of them owing to multiple local recurrences with extension to the temporal bone, and another owing to metastatic dissemination to cervical lymph nodes, pleura, pericardium, and lungs. We have shown a t(12;15) (p13;q25) ETV6-NTRK3 translocation in all but one case of MASC suitable for analysis. One case was not analyzable and another was not available for testing. This translocation was not found in any conventional salivary AciCC (12 cases), nor in other tumor types including pleomorphic adenoma (1 case) and low-grade cribriform cystadenocarcinoma (1 case), whereas ETV6-NTRK3 gene rearrangements were proven in all 3 tested cases of

  20. Neurosurgery Education and Development program to treat hydrocephalus and to develop neurosurgery in Africa using mobile neuroendoscopic training.

    Science.gov (United States)

    Piquer, José; Qureshi, Mubashir Mahmood; Young, Paul H; Dempsey, Robert J

    2015-06-01

    OBJECT A shortage of neurosurgeons and a lack of knowledge of neuroendoscopic management of hydrocephalus limits modern care in sub-Saharan Africa. Hence, a mobile teaching project for endoscopic third ventriculostomy (ETV) procedures and a subsequent program to develop neurosurgery as a permanent specialty in Kenya and Zanzibar were created and sponsored by the Neurosurgery Education and Development (NED) Foundation and the Foundation for International Education in Neurological Surgery. The objective of this work was to evaluate the results of surgical training and medical care in both projects from 2006 to 2013. METHODS Two portable neuroendoscopy systems were purchased and a total of 38 ETV workshops were organized in 21 hospitals in 7 different countries. Additionally, 49 medical expeditions were dispatched to the Coast General Hospital in Mombasa, Kenya, and to the Mnazi Moja Hospital in Zanzibar. RESULTS From the first project, a total of 376 infants with hydrocephalus received surgery. Six-month follow-up was achieved in 22%. In those who received follow-up, ETV efficacy was 51%. The best success rates were achieved with patients 1 year of age or older with aqueductal stenosis (73%). The main causes of hydrocephalus were infection (56%) and spina bifida (23%). The mobile education program interacted with 72 local surgeons and 122 nurses who were trained in ETV procedures. The second project involved 49 volunteer neurosurgeons who performed a total of 360 nonhydrocephalus neurosurgical operations since 2009. Furthermore, an agreement with the local government was signed to create the Mnazi Mmoja NED Institute in Zanzibar. CONCLUSIONS Mobile endoscopic treatment of hydrocephalus in East Africa results in reasonable success rates and has also led to major developments in medicine, particularly in the development of neurosurgery specialty care sites.

  1. What hides behind the MASC: clinical response and acquired resistance to entrectinib after ETV6-NTRK3 identification in a mammary analogue secretory carcinoma (MASC).

    Science.gov (United States)

    Drilon, A; Li, G; Dogan, S; Gounder, M; Shen, R; Arcila, M; Wang, L; Hyman, D M; Hechtman, J; Wei, G; Cam, N R; Christiansen, J; Luo, D; Maneval, E C; Bauer, T; Patel, M; Liu, S V; Ou, S H I; Farago, A; Shaw, A; Shoemaker, R F; Lim, J; Hornby, Z; Multani, P; Ladanyi, M; Berger, M; Katabi, N; Ghossein, R; Ho, A L

    2016-05-01

    Mammary analogue secretory carcinoma (MASC) is a recently described pathologic entity. We report the case of a patient with an initial diagnosis of salivary acinic cell carcinoma later reclassified as MASC after next-generation sequencing revealed an ETV6-NTRK3 fusion. This alteration was targeted with the pan-Trk inhibitor entrectinib (Ignyta), which possesses potent in vitro activity against cell lines containing various NTRK1/2/3 fusions. A dramatic and durable response was achieved with entrectinib in this patient, followed by acquired resistance that correlated with the appearance of a novel NTRK3 G623R mutation. Structural modeling predicts that this alteration sterically interferes with drug binding, correlating to decreased sensitivity to drug inhibition observed in cell-based assays. This first report of clinical activity with TrkC inhibition and the development of acquired resistance in an NTRK3-rearranged cancer emphasize the utility of comprehensive molecular profiling and targeted therapy for rare malignancies (NCT02097810). © The Author 2016. Published by Oxford University Press on behalf of the European Society for Medical Oncology.

  2. Television Utilization.

    Science.gov (United States)

    Dobosh, O.; Wright, E. N.

    The utilization of educational television (ETV) in schools can be ascertained by considering the teacher training in ETV, the extent of access to ETV, the student reaction, and the programing. Using a questionnaire survey method combined with detailed ETV logs, this study was able to analyze both ETV and film utilization in 13 elementary and…

  3. Closed Cycle Engine Program Used in Solar Dynamic Power Testing Effort

    Science.gov (United States)

    Ensworth, Clint B., III; McKissock, David B.

    1998-01-01

    NASA Lewis Research Center is testing the world's first integrated solar dynamic power system in a simulated space environment. This system converts solar thermal energy into electrical energy by using a closed-cycle gas turbine and alternator. A NASA-developed analysis code called the Closed Cycle Engine Program (CCEP) has been used for both pretest predictions and post-test analysis of system performance. The solar dynamic power system has a reflective concentrator that focuses solar thermal energy into a cavity receiver. The receiver is a heat exchanger that transfers the thermal power to a working fluid, an inert gas mixture of helium and xenon. The receiver also uses a phase-change material to store the thermal energy so that the system can continue producing power when there is no solar input power, such as when an Earth-orbiting satellite is in eclipse. The system uses a recuperated closed Brayton cycle to convert thermal power to mechanical power. Heated gas from the receiver expands through a turbine that turns an alternator and a compressor. The system also includes a gas cooler and a radiator, which reject waste cycle heat, and a recuperator, a gas-to-gas heat exchanger that improves cycle efficiency by recovering thermal energy.

  4. Extra Copies of der(21t(12;21 plus Deletion of ETV6 Gene due to dic(12;18 in B-Cell Precursor ALL with Poor Outcome

    Directory of Open Access Journals (Sweden)

    Marina Araújo Fonzar Hernandes

    2012-01-01

    Full Text Available Acute lymphoblastic leukemia (ALL, CD10+ B-cell precursor, represents the most frequent type of childhood ALL from 3 to 6 years of age. The t(12;21(p13;q22 occurs in 25% of cases of B-cell precursor ALL, it is rare in children less than 24 months and have been related to good prognosis. Some relapse cases and unfavorable prognosis in ALL CD10+ are associated with t(12;21 bearing additional aberrations as extra copies of chromosome 21 and ETV6 gene loss. This report describes the case of a 15 month-year old girl, who displayed a karyotype with addition on chromosome 12p plus trisomy 10 and tetrasomy of chromosome 21. Molecular cytogenetic studies revealed two extra copies of the der(21 t(12;21, trisomy 10 and deletion of the second ETV6 gene due to the dic(12;18. These findings show the great importance of molecular cytogenetic studies to clarify complex karyotypes, to define prognostic, to carry out risk group stratification and to support correctly disease treatment in childhood acute lymphoblastic leukemia.

  5. enter endoscopic third ventriculostomy (ETV)

    African Journals Online (AJOL)

    which is characterised by hemosiderin deposits, inflammatory exudates and intraventricular septations, among others features. Since Waluza and Borgstein's report in 2005, there are indications that the burden of hydrocephalus at QECH is on the increase (personal observation). This may be due to increased awareness of ...

  6. ETV laiendab filmiskaalat / Tarmo Teder

    Index Scriptorium Estoniae

    Teder, Tarmo, 1958-

    2003-01-01

    Eesti Televisioonis näidatud filme - Concordia tudengite "Hüvasti igaveseks, Värdjad!" : autorid Liina Paakspuu, Kadriann Kibus ja dokumentaalfilm sõjafotograaf James Nachtwey'st "Sõjafotograaf" ("War Photographer") : autor Christian Frei : Šveits 2001

  7. GENERIC VERIFICATION PROTOCOL FOR DETERMINATION OF EMISSIONS REDUCTIONS FROM SELECTIVE CATALYTIC REDUCTIONS CONTROL TECHNOLOGIES FOR HIGHWAY, NONROAD, AND STATIONARY USE DIESEL ENGINES

    Science.gov (United States)

    The protocol describes the Environmental Technology Verification (ETV) Program's considerations and requirements for verification of emissions reduction provided by selective catalytic reduction (SCR) technologies. The basis of the ETV will be comparison of the emissions and perf...

  8. Environmental Technology Verification: Baghouse Filtration Products--Donaldson Co., Inc., Tetratec #6255-3 Filtration Media

    Science.gov (United States)

    The U.S. Environmental Protection Agency (EPA) has created the Environmental Technology Verification (ETV) Program to facilitate the deployment of innovative or improved environmental technologies through performance verification and dissemination of information. ETV seeks to ach...

  9. Environmental Technology Verification: Baghouse filtration products--W.L. Gore & Associates L3650 filtration media (tested November--December 2009)

    Science.gov (United States)

    The U.S. Environmental Protection Agency (EPA) has created the Environmental Technology Verification (ETV) Program to facilitate the deployment of innovative or improved environmental technologies through performance verification and dissemination of information. ETV seeks to ach...

  10. Environmental Technology Verification: Baghouse Filtration Products--TDC Filter Manufacturing, Inc., SB025 Filtration Media

    Science.gov (United States)

    The U.S. Environmental Protection Agency (EPA) has created the Environmental Technology Verification (ETV) Program to facilitate the deployment of innovative or improved environmental technologies through performance verification and dissemination of information. ETV seeks to ach...

  11. Environmental Technology Verification Report: Baghouse Filtration Products, Donaldson Company, Inc. Tetratex® 6277 Filtration Media (Tested March 2011)

    Science.gov (United States)

    The U.S. Environmental Protection Agency (EPA) has created the Environmental Technology Verification (ETV) Program to facilitate the deployment of innovative or improved environmental technologies through performance verification and dissemination of information. ETV seeks to ach...

  12. Environmental Technology Verification Report: Baghouse Filtration Products, Donaldson Company, Inc. Tetratex® 6262 Filtration Media (Tested March 2011)

    Science.gov (United States)

    The U.S. Environmental Protection Agency (EPA) has created the Environmental Technology Verification (ETV) Program to facilitate the deployment of innovative or improved environmental technologies through performance verification and dissemination of information. ETV seeks to ach...

  13. Environmental Technology Verification Report: Baghouse Filtration Products, Donaldson Company, Inc. Tetratex® 6282 Filtration Media (Tested March - April 2011)

    Science.gov (United States)

    The U.S. Environmental Protection Agency (EPA) has created the Environmental Technology Verification (ETV) Program to facilitate the deployment of innovative or improved environmental technologies through performance verification and dissemination of information. ETV seeks to ach...

  14. ETV/ESTE RADIO FREQUENCY IDENTIFICATION PROJECT

    Science.gov (United States)

    The final product for book chapter is not available for this material. If further information is needed, please refer to the bibliographic citation and contact the person listed under the Contract Field.

  15. Russkoje ETV "sdelalo" "Al Dzhaziru" / Alina Zelimhanova

    Index Scriptorium Estoniae

    Zelimhanova, Alina

    2004-01-01

    Eesti Televisiooni venekeelsete saadete toimetuse saade "Mitmepalgeline Peterburi" (režissöör Olga Martõnova, toimetaja Natalja Malleus) võitis Moskva rahvusvahelisel ajakirjanike konkursil "Kuldne verb" teise koha auhinnaklassis "Täpne pilk"

  16. Pärnu filmifestival taas ETVs

    Index Scriptorium Estoniae

    2007-01-01

    XXI Rahvusvaheline Pärnu filmifestival : Eesti Televisioon näitab 8.-14.07. eriprogrammi, kuhu on valitud filmid "Minu surm, mitte sinu" (Saksamaa-India 2006), "Valgevene õppetund" (Poola-Valgevene 2006), "Beslan - õigus elada" (Venemaa 2006), "Esimene rahu õppetund" (Iisrael 2006), "Õnne vaenlased" (Taani-Afganistan 2006), "Mu tütar on terrorist" (Norra 2006) ja "Lugu kehast" (Iisrael 2006)

  17. Etv4 and Etv5 transcription factors as mediators of neurotrophic factor signaling and development

    OpenAIRE

    Fontanet, Paula A.

    2015-01-01

    El preciso desarrollo de las conexiones neuronales es esencial para el correcto funcionamiento del sistema nervioso, y la falta de precisión en este proceso está asociada al desarrollo de diferentes patologías. La formación de los circuitos neuronales depende de la interacción de factores celulares intrínsecos y extrínsecos, que regulan la transmisión de la información en el sistema nervioso. Entre estos, los factores neurotróficos (FN) cumplen roles esenciales en el mantenimiento y sobrevida...

  18. AFSC/NMML/CCEP: Capture and resight data of California sea lions in Washington State, 1989 to 2006

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This dataset contains data from the capture and recapture of over 1500 male California sea lions (Zalophus californianus) from Washington between 1989-2006. The data...

  19. AFSC/NMML/CCEP: Survival Rate of California sea lions at San Miguel Island, California from 1987-2009

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The dataset contains initial capture and marking data for California sea lion (Zalophus californianus) pups at San Miguel Island, California and subsequent...

  20. Program specialization

    CERN Document Server

    Marlet, Renaud

    2013-01-01

    This book presents the principles and techniques of program specialization - a general method to make programs faster (and possibly smaller) when some inputs can be known in advance. As an illustration, it describes the architecture of Tempo, an offline program specializer for C that can also specialize code at runtime, and provides figures for concrete applications in various domains. Technical details address issues related to program analysis precision, value reification, incomplete program specialization, strategies to exploit specialized program, incremental specialization, and data speci

  1. Parenting Programs

    Directory of Open Access Journals (Sweden)

    Juan Carlos Martín-Quintana

    2010-01-01

    Full Text Available This paper was aimed at emphasizing the importance of using parenting programs to promote parental competences. There is a need for this support taking into account the complexity of the parenting task in our modern societies. Following the European recommendation on positive parenting, those parenting programs are considered important measures to support parents in their educational role. Forward, several generations of parenting programs at the international context were briefly described and some examples of programs within the national context, as well. This paper provides some reflection on three models of parental education, and shows the results of an experiential parenting programs addressed to parents in psychosocial risk situation in two Spanish communities. A new program “Crecer felices en familia”, still in the implementation phase, was also described. As a conclusion, the paper emphasized the importance of evaluating programs in order to know more about their efficacy and to improve the way of implementation in real settings.

  2. Eurovisiooni vaheklipid tõid ETV-le Aumuna

    Index Scriptorium Estoniae

    2003-01-01

    Mulluse Eurovisiooni lauluvõistluse Tallinna kontserdi vaheklipid said Eesti reklaamiauhindade Kuldmuna jagamisel Aumuna. Üks vaheklippidest "Saabastega kass", mille režissöörid on René Vilbre ja Meelis Arulepp, valiti maineka Annecy animafilmifestivali nominentide hulka. 2 klippi valiti Norras Fredrikstadis toimuva animafestivali programmi. Praegu teeb Rene Vilbre koos võttegrupiga Euroopa Liidu referendumi teemalisi klippe

  3. ETV näitab modernklassikat / Tiit Merisalu

    Index Scriptorium Estoniae

    Merisalu, Tiit

    1999-01-01

    Teleseriaal "Sume on öö" ("Tender is the Night") : stsenarist Dennis Potter Francis Scott Fitzgeraldi romaani järgi : režissöör Robert Knight : Suurbritannia - Austraalia - Ameerika Ühendriigid 1985

  4. ETV Tech Brief: Rapid Fungi and Bacteria Detection Technologies

    Science.gov (United States)

    Technical brief that summarizes the results for Mycometer, Inc. Mycometer®-test and Bactiquant®-test, which are rapid detection technologies for fungi and bacteria. The brief summarizes the results of the verification report and statement.

  5. Material Programming

    DEFF Research Database (Denmark)

    Vallgårda, Anna; Boer, Laurens; Tsaknaki, Vasiliki

    2017-01-01

    , and color, but additionally being capable of sensing, actuating, and computing. Indeed, computers will not be things in and by themselves, but embedded into the materials that make up our surroundings. This also means that the way we interact with computers and the way we program them, will change....... Consequently we ask what the practice of programming and giving form to such materials would be like? How would we be able to familiarize ourselves with the dynamics of these materials and their different combinations of cause and effect? Which tools would we need and what would they look like? Will we program...... these computational composites through external computers and then transfer the code them, or will the programming happen closer to the materials? In this feature we outline a new research program that floats between imagined futures and the development of a material programming practice....

  6. Effective Programming

    DEFF Research Database (Denmark)

    Frost, Jacob

    To investigate the use of VTLoE as a basis for formal derivation of functional programs with effects. As a part of the process, a number of issues central to effective formal programming are considered. In particular it is considered how to develop a proof system suitable for pratical reasoning......, how to implement this system in the generic proof assistant Isabelle and finally how to apply the logic and the implementation to programming....

  7. Program Fullerene

    DEFF Research Database (Denmark)

    Wirz, Lukas; Peter, Schwerdtfeger,; Avery, James Emil

    2013-01-01

    Fullerene (Version 4.4), is a general purpose open-source program that can generate any fullerene isomer, perform topological and graph theoretical analysis, as well as calculate a number of physical and chemical properties. The program creates symmetric planar drawings of the fullerene graph......-Fowler, and Brinkmann-Fowler vertex insertions. The program is written in standard Fortran and C++, and can easily be installed on a Linux or UNIX environment....

  8. Programming Interactivity

    CERN Document Server

    Noble, Joshua

    2009-01-01

    Make cool stuff. If you're a designer or artist without a lot of programming experience, this book will teach you to work with 2D and 3D graphics, sound, physical interaction, and electronic circuitry to create all sorts of interesting and compelling experiences -- online and off. Programming Interactivity explains programming and electrical engineering basics, and introduces three freely available tools created specifically for artists and designers: Processing, a Java-based programming language and environment for building projects on the desktop, Web, or mobile phonesArduino, a system t

  9. Programming F#

    CERN Document Server

    Smith, Chris

    2009-01-01

    Why learn F#? This multi-paradigm language not only offers you an enormous productivity boost through functional programming, it also lets you develop applications using your existing object-oriented and imperative programming skills. With Programming F#, you'll quickly discover the many advantages of Microsoft's new language, which includes access to all the great tools and libraries of the .NET platform. Learn how to reap the benefits of functional programming for your next project -- whether it's quantitative computing, large-scale data exploration, or even a pursuit of your own. With th

  10. Quality Assurance Project Plan: Suitability of Leak Detection Technology for Use In Ethanol-Blended Fuel Service

    Science.gov (United States)

    Oversight of this investigation will be provided by the U.S. Environmental Protection Agency through the Environmental Technology Verification (ETV) Program. This project will be performed by Battelle, which manages the ETV Advanced Monitoring Systems (AMS) Center through a coop...

  11. Test/QA Plan for Verification of Radio Frequency Identification (RFID) for Tracking Hazardous Waste Shipments across International Borders

    Science.gov (United States)

    The verification test will be conducted under the auspices of the U.S. Environmental Protection Agency (EPA) through the Environmental Technology Verification (ETV) Program. It will be performed by Battelle, which is managing the ETV Advanced Monitoring Systems (AMS) Center throu...

  12. Environmental Technology Verification--Baghouse Filtration Products: GE Energy QG061 Filtration Media (Tested September 2008)

    Science.gov (United States)

    This report reviews the filtration and pressure drop performance of GE Energy's QG061 filtration media. Environmental Technology Verification (ETV) testing of this technology/product was conducted during a series of tests in September 2008. The objective of the ETV Program is to ...

  13. ENVIRONMENTAL TECHNOLOGY VERIFICATION OF BAGHOUSE FILTRATION PRODUCTS

    Science.gov (United States)

    The Environmental Technology Verification Program (ETV) was started by EPA in 1995 to generate independent credible data on the performance of innovative technologies that have potential to improve protection of public health and the environment. ETV does not approve or certify p...

  14. Computer Programs.

    Science.gov (United States)

    Anderson, Tiffoni

    This module provides information on development and use of a Material Safety Data Sheet (MSDS) software program that seeks to link literacy skills education, safety training, and human-centered design. Section 1 discusses the development of the software program that helps workers understand the MSDSs that accompany the chemicals with which they…

  15. Choreographic Programming

    DEFF Research Database (Denmark)

    Montesi, Fabrizio

    , as they offer a concise view of the message flows enacted by a system. For this reason, in the last decade choreographies have been used in the development of programming languages, giving rise to a programming paradigm that in this dissertation we refer to as Choreographic Programming. Recent studies show...... endpoint described in a choreography can then be automatically generated, ensuring that such implementations are safe by construction. However, current formal models for choreographies do not deal with critical aspects of distributed programming, such as asynchrony, mobility, modularity, and multiparty...... sessions; it remains thus unclear whether choreographies can still guarantee safety when dealing with such nontrivial features. This PhD dissertation argues for the suitability of choreographic programming as a paradigm for the development of safe distributed systems. We proceed by investigating its...

  16. Programming Python

    CERN Document Server

    Lutz, Mark

    2011-01-01

    If you've mastered Python's fundamentals, you're ready to start using it to get real work done. Programming Python will show you how, with in-depth tutorials on the language's primary application domains: system administration, GUIs, and the Web. You'll also explore how Python is used in databases, networking, front-end scripting layers, text processing, and more. This book focuses on commonly used tools and libraries to give you a comprehensive understanding of Python's many roles in practical, real-world programming. You'll learn language syntax and programming techniques in a clear and co

  17. Programming Python

    National Research Council Canada - National Science Library

    Lutz, Mark

    2006-01-01

    ... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 3 3 8 9 15 17 20 22 2. A Sneak Preview "Programming Python: The Short Story" The Task Step 1: Representing Records Step 2: Storing Records Persistently Step 3...

  18. Linear programming

    CERN Document Server

    Solow, Daniel

    2014-01-01

    This text covers the basic theory and computation for a first course in linear programming, including substantial material on mathematical proof techniques and sophisticated computation methods. Includes Appendix on using Excel. 1984 edition.

  19. Army Programs: Army Energy Program

    Science.gov (United States)

    1997-02-03

    the Energy Program. o Expands the responsibilities of the Assistant Chief of Staff for Installation Management (para 1-4). o Includes ridesharing as...not been highlighted. Summary. This regulation establishes poli- cies, procedures, and responsibilities for the Army Energy Program. Applicability ...Energy Technology Service (FETS) • 3–13, page 6 Energy Surveys • 3–14, page 6 Army Energy Awareness Seminars • 3–15, page 6 Army ridesharing • 3–16

  20. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Program Commission on Cancer National Accreditation Program for Breast Centers National Cancer Database National Accreditation Program for Rectal Cancer Oncology Medical Home Accreditation Program Stereotactic Breast Biopsy Accreditation Program Cancer Programs Staff Information Children's ...

  1. Programming Algol

    CERN Document Server

    Malcolme-Lawes, D J

    2014-01-01

    Programming - ALGOL describes the basics of computer programming using Algol. Commands that could be added to Algol and could increase its scope are described, including multiplication and division and the use of brackets. The idea of labeling or naming a command is also explained, along with a command allowing two alternative results. Most of the important features of Algol syntax are discussed, and examples of compound statements (that is, sets of commands enclosed by a begin ... end command) are given.Comprised of 11 chapters, this book begins with an introduction to the digital computer an

  2. Programming Interactivity

    CERN Document Server

    Noble, Joshua

    2012-01-01

    Ready to create rich interactive experiences with your artwork, designs, or prototypes? This is the ideal place to start. With this hands-on guide, you'll explore several themes in interactive art and design-including 3D graphics, sound, physical interaction, computer vision, and geolocation-and learn the basic programming and electronics concepts you need to implement them. No previous experience is necessary. You'll get a complete introduction to three free tools created specifically for artists and designers: the Processing programming language, the Arduino microcontroller, and the openFr

  3. ICD programming

    OpenAIRE

    Biffi, Mauro

    2014-01-01

    Background: Appropriate ICD programming is the key to prevent inappropriate shock delivery, that is closely associated to a negative patients' outcome. Methods: Review of the literature on ICD therapy to generate ICD programmings that can be applied to the broad population of ICD and CRT-D carriers. Results: Arrhythmia detection should occur with a detection time ranging 9″–12″ in the VF zone, and 15″–60″ in the VT zone. Discriminator should be applied at least up to 200 bpm. ATP therap...

  4. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Safety Conference Registry Login SCR Training and Testing Cancer Cancer Programs Cancer Programs Overview of Cancer Programs Cancer Programs News American Joint Committee on ...

  5. Use of Radio Frequency Identification (RFID) for Tracking Hazardous Waste Shipments Across International Borders -Test/QA Plan

    Science.gov (United States)

    The Environmental Technology Verification (ETV) – Environmental and Sustainable Technology Evaluations (ESTE) Program conducts third-party verification testing of commercially available technologies that may accomplish environmental program management goals. In this verification...

  6. ENVIRONMENTAL TECHNOLOGY VERIFICATION REPORT, GROUNDWATER SAMPLING TECHNOLOGIES, GEOLOG, INC., MICRO-FLO BLADDER PUMP MODEL 57400

    Science.gov (United States)

    The U.S. Environmental Protection Agency has created the Environmental Technology Verification Program to facilitate the deployment of innovative or improved environmental technologies through performance verification and dissemination of information. The goal of the ETV Program...

  7. Program Proposal

    Science.gov (United States)

    Baskas, Richard S.

    2012-01-01

    A study was conducted to determine if a deficiency, or learning gap, existed in a particular working environment. To determine if an assessment was to be conducted, a program proposal would need to be developed to explore this situation. In order for a particular environment to react and grow with other environments, it must be able to take on…

  8. Sprego Programming

    Directory of Open Access Journals (Sweden)

    Maria Csernoch

    2015-02-01

    Full Text Available Spreadsheet management is a border-land between office applications and programming, however, it is rather communicated that spreadsheet is nothing more than an easily handled fun piece. Consequently, the complexity of spreadsheet handling, the unprepared end-users, their problem solving abilities and approaches do not match. To overcome these problems we have developed and introduced Sprego (Spreadsheet Lego. Sprego is a simplified functional programming language in spreadsheet environment, and such as can be used both as introductory language and the language of end-user programmers. The essence of Sprego is that we use as few and simple functions as possible and based on these functions build multilevel formulas. With this approach, similar to high level programming, we are able solve advanced problems, developing algorithmic skills, computational thinking. The advantage of Sprego is the simplicity of the language, when the emphasis is not on the coding but on the problem. Beyond that spreadsheets would provide real life problems with authentic data and tables which students are more interested in than the artificial environment and semi-authentic problems of high level programming languages.

  9. Constraint Programming versus Mathematical Programming

    DEFF Research Database (Denmark)

    Hansen, Jesper

    2003-01-01

    Constraint Logic Programming (CLP) is a relatively new technique from the 80's with origins in Computer Science and Artificial Intelligence. Lately, much research have been focused on ways of using CLP within the paradigm of Operations Research (OR) and vice versa. The purpose of this paper...

  10. Linear programming

    CERN Document Server

    Karloff, Howard

    1991-01-01

    To this reviewer’s knowledge, this is the first book accessible to the upper division undergraduate or beginning graduate student that surveys linear programming from the Simplex Method…via the Ellipsoid algorithm to Karmarkar’s algorithm. Moreover, its point of view is algorithmic and thus it provides both a history and a case history of work in complexity theory. The presentation is admirable; Karloff's style is informal (even humorous at times) without sacrificing anything necessary for understanding. Diagrams (including horizontal brackets that group terms) aid in providing clarity. The end-of-chapter notes are helpful...Recommended highly for acquisition, since it is not only a textbook, but can also be used for independent reading and study. —Choice Reviews The reader will be well served by reading the monograph from cover to cover. The author succeeds in providing a concise, readable, understandable introduction to modern linear programming. —Mathematics of Computing This is a textbook intend...

  11. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Inspiring Quality Initiative Resources Continuous Quality Improvement ACS Clinical Scholars in Residence AHRQ Safety Program for ISCR ... Advocacy Efforts Cancer Liaison Program Cancer Programs Conference Clinical Research Program Commission on Cancer National Accreditation Program ...

  12. AFSC/NMML/CCEP: Characterizing and quantifying California sea lion and Pacific harbor seal use of offshore oil and gas platforms in California, 2013-2015

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — California sea lions (Zalophus californianus) and Pacific harbor seals (Phoca vitulina) use offshore oil and gas platforms as resting and foraging areas. Both...

  13. AFSC/NMML/CCEP: Raw telemetry data for California sea lions and northern fur seals in waters off California, Oregon, and Washington during 2002-2007

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The purpose of this project was to obtain data that are pertinent to assessing aspects of the distribution and foraging ecology of pinnipeds inhabiting the...

  14. AFSC/NMML/CCEP: Hookworm Intensity of Infection in California sea lion and Northern Fur Seal Pups in California, 1996 through 2008

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — There are various causes of mortality for California sea lion (Zalophus californianus) and northern fur seal (Callorhinus ursinus) pups. This dataset contains...

  15. Programming Pig

    CERN Document Server

    Gates, Alan

    2011-01-01

    This guide is an ideal learning tool and reference for Apache Pig, the open source engine for executing parallel data flows on Hadoop. With Pig, you can batch-process data without having to create a full-fledged application-making it easy for you to experiment with new datasets. Programming Pig introduces new users to Pig, and provides experienced users with comprehensive coverage on key features such as the Pig Latin scripting language, the Grunt shell, and User Defined Functions (UDFs) for extending Pig. If you need to analyze terabytes of data, this book shows you how to do it efficiently

  16. Programming Razor

    CERN Document Server

    Chadwick, Jess

    2011-01-01

    Take Razor for a test drive and discover first hand how this scripting syntax simplifies the way you create dynamic, data-driven websites. With this concise guide, you'll work with Razor syntax by building example websites with Microsoft WebMatrix and ASP.NET MVC. You'll quickly learn how Razor lets you combine code and content in a fluid and expressive manner on Windows-based servers. Programming Razor also explores components of the Razor API, and shows you how Razor templates are turned into rendered HTML. By the end of this book, you'll be able to create Razor-based websites with custom

  17. Geothermal Technologies Program Overview - Peer Review Program

    Energy Technology Data Exchange (ETDEWEB)

    Milliken, JoAnn [Office of Energy Efficiency and Renewable Energy (EERE), Washington, DC (United States)

    2011-06-06

    This Geothermal Technologies Program presentation was delivered on June 6, 2011 at a Program Peer Review meeting. It contains annual budget, Recovery Act, funding opportunities, upcoming program activities, and more.

  18. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Accreditation Program Stereotactic Breast Biopsy Accreditation Program Cancer Programs Staff Information Children's Surgery Children's Surgery Children's Surgery Children's Surgery Verification ...

  19. Annotated Answer Set Programming

    OpenAIRE

    Straccia, Umberto

    2005-01-01

    We present Annotated Answer Set Programming, that extends the ex pressive power of disjunctive logic programming with annotation terms, taken from the generalized annotated logic programming framework.

  20. Functional Python programming

    CERN Document Server

    Lott, Steven

    2015-01-01

    This book is for developers who want to use Python to write programs that lean heavily on functional programming design patterns. You should be comfortable with Python programming, but no knowledge of functional programming paradigms is needed.

  1. Human Reliability Program Overview

    Energy Technology Data Exchange (ETDEWEB)

    Bodin, Michael

    2012-09-25

    This presentation covers the high points of the Human Reliability Program, including certification/decertification, critical positions, due process, organizational structure, program components, personnel security, an overview of the US DOE reliability program, retirees and academia, and security program integration.

  2. Vehicle Technologies Program Overview

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2006-09-05

    Overview of the Vehicle Technologies Program including external assessment and market view; internal assessment, program history and progress; program justification and federal role; program vision, mission, approach, strategic goals, outputs, and outcomes; and performance goals.

  3. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Quality Improvement Program About Standards Apply Participant Use Data File (PUF) Resources & FAQs Find a MBSAQIP Center ... Programs BleedingControl.org Trauma Quality Programs National Trauma Data Bank Trauma Quality Improvement Program Mentoring for Excellence ...

  4. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Overview of Cancer Programs Cancer Programs News American Joint Committee on Cancer Cancer Advocacy Efforts Cancer Liaison ... Validation Programs Accredited Education Institutes CME Accreditation CME Joint Providership Program Verification of Knowledge and Skills Resources ...

  5. ENVIRONMENTAL TECHNOLOGY VERIFICATION REPORT - BAGHOUSE FILTRATION PRODUCTS - INSPEC FIBRES 5512BRF FILTER SAMPLE

    Science.gov (United States)

    Baghouse filtration products (BFPs) were evaluated by the Air Pollution Control Technology (APCT) pilot of the Environmental Technology Verification (ETV) Program. The performance factor verified was the mean outlet particle concentration for the filter fabric as a function of th...

  6. Environmental Technology Verification Report: Taconic Energy, Inc. TEA Fuel Additive

    Science.gov (United States)

    The Greenhouse Gas Technology Center (GHG Center) is one of six verification organizations operating under EPA’s ETV program. One sector of significant interest to GHG Center stakeholders is transportation - particularly technologies that result in fuel economy improvements. Taco...

  7. ENVIRONMENTAL TECHNOLOGY VERIFICATION REPORT - BAGHOUSE FILTRATION PRODUCTS - ALBANY INTERNATIONAL CORP. INDUSTRIAL PROCESS TECHNOLOGIES PRIMATEX PLUS I FILTER SAMPLE

    Science.gov (United States)

    Baghouse filtration products (BFPs) were evaluated by the Air Pollution Control Technology (APCT) pilot of the Environmental Technology Verification (ETV) Program. The performance factor verified was the mean outlet particle concentration for the filter fabric as a function of th...

  8. ENVIRONMENTAL TECHNOLOGY VERIFICATION REPORT--BAGHOUSE FILTRATION PRODUCTS, DONALDSON COMPANY, INC., 6282 FILTRATION MEDIA

    Science.gov (United States)

    The Environmental Technology Verification (ETV) Program, established by the U.S. EPA, is designed to accelerate the developmentand commercialization of new or improved technologies through third-party verification and reporting of performance. The Air Pollution Control Technology...

  9. ENVIRONMENTAL TECHNOLOGY VERIFICATION REPORT - BAGHOUSE FILTRATION PRODUCTS - STANDARD FILTER CORPORATION PE16ZU FILTER SAMPLE

    Science.gov (United States)

    Baghouse filtration products (BFPs) were evaluated by the Air Pollution Control Technology (APCT) pilot of the Environmental Technology Verification (ETV) Program. The performance factor verified was the mean outlet particle concentration for the filter fabric as a function of th...

  10. ENVIRONMENTAL TECHNOLOGY VERIFICATION REPORT: BAGHOUSE FILTRATION PRODUCTS--DONALDSON COMPANY, INC., TETRATEC #6255 FILTRATION MEDIA

    Science.gov (United States)

    The Environmental Technology Verification (ETV) Program, established by the U.S. EPA, is designed to accelerate the development and commercialization of new or improved technologies through third-party verification and reporting of performance. The Air Pollution Control Technolog...

  11. ENVIRONMENTAL TECHNOLOGY VERIFICATION REPORT - BAGHOUSE FILTRATION PRODUCTS - W.L. GORE & ASSOCIATES, INC. L4347 FILTER SAMPLE

    Science.gov (United States)

    Baghouse filtration products (BFPs) were evaluated by the Air Pollution Control Technology (APCT) pilot of the Environmental Technology Verification (ETV) Program. The performance factor verified was the mean outlet particle concentration for the filter fabric as a function of th...

  12. Environmental Technology Verification: Baghouse Filtration Products--Sinoma Science & Technology Co. Ltd FT-806 Filtration Media

    Science.gov (United States)

    EPA created the Environmental Technology Verification (ETV) Program to facilitate the deployment of innovative or improved environmental technologies through performance verification and dissemination of information. It seeks to achieve this goal by providing high-quality, peer r...

  13. Behavioral program synthesis with genetic programming

    CERN Document Server

    Krawiec, Krzysztof

    2016-01-01

    Genetic programming (GP) is a popular heuristic methodology of program synthesis with origins in evolutionary computation. In this generate-and-test approach, candidate programs are iteratively produced and evaluated. The latter involves running programs on tests, where they exhibit complex behaviors reflected in changes of variables, registers, or memory. That behavior not only ultimately determines program output, but may also reveal its `hidden qualities' and important characteristics of the considered synthesis problem. However, the conventional GP is oblivious to most of that information and usually cares only about the number of tests passed by a program. This `evaluation bottleneck' leaves search algorithm underinformed about the actual and potential qualities of candidate programs. This book proposes behavioral program synthesis, a conceptual framework that opens GP to detailed information on program behavior in order to make program synthesis more efficient. Several existing and novel mechanisms subs...

  14. NASA's educational programs

    Science.gov (United States)

    Brown, Robert W.

    1990-01-01

    The educational programs of NASA's Educational Affairs Division are examined. The problem of declining numbers of science and engineering students is reviewed. The various NASA educational programs are described, including programs at the elementary and secondary school levels, teacher education programs, and undergraduate, graduate, and university faculty programs. The coordination of aerospace education activities and future plans for increasing NASA educational programs are considered.

  15. An Intelligent Robot Programing

    Energy Technology Data Exchange (ETDEWEB)

    Hong, Seong Yong

    2012-01-15

    This book introduces an intelligent robot programing with background of the begging, introduction of VPL, and SPL, building of environment for robot platform, starting of robot programing, design of simulation environment, robot autonomy drive control programing, simulation graphic. Such as SPL graphic programing graphical image and graphical shapes, and graphical method application, application of procedure for robot control, robot multiprogramming, robot bumper sensor programing, robot LRF sencor programing and robot color sensor programing.

  16. System programming languages

    OpenAIRE

    Šmit, Matej

    2016-01-01

    Most operating systems are written in the C programming language. Similar is with system software, for example, device drivers, compilers, debuggers, disk checkers, etc. Recently some new programming languages emerged, which are supposed to be suitable for system programming. In this thesis we present programming languages D, Go, Nim and Rust. We defined the criteria which are important for deciding whether programming language is suitable for system programming. We examine programming langua...

  17. Operations Program Executive

    Science.gov (United States)

    Fague, M. A.

    1982-01-01

    Ground Resource Operations Program executive (GROPE) is control program for binding system of programs into single, easily operated entity. It relieves user from complexity arising from decomposition of large application into number of interacting program units. System simplifies job control, data management, and recordkeeping for interacting programs.

  18. Lippincott Basic Reading Program.

    Science.gov (United States)

    Monterey Peninsula Unified School District, Monterey, CA.

    This program, included in "Effective Reading Programs...," serves 459 students in grades 1-3 at 15 elementary schools. The program employs a diagnostic-prescriptive approach to instruction in a nongraded setting through the use of the Lippincott Basic Reading program. When a child enters the program, he is introduced to a decoding…

  19. Structured Programming: An Introduction.

    Science.gov (United States)

    Moulton, Peter

    Designed for use by computer programming teachers, this booklet presents the concepts of structured programming and provides examples of how to implement this methodology, which provides a systematic way of organizing programs so that even large and complex programs are easier to understand and modify than unstructured programs. After a brief…

  20. Energy Technology Programs: program summaries for 1979

    Energy Technology Data Exchange (ETDEWEB)

    1979-12-01

    The Energy Technology Programs in the BNL Department of Energy and Environment cover a broad range of activities, namely: electrochemical research, chemical energy storage, chemical heat pumps, solar technology, fossil technology, catalytic systems development, space-conditioning technology, and technical support/program management. Summaries of the individual tasks associated with these activities along with publications, significant accomplishments, and program funding levels are presented.

  1. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Trauma Quality Programs National Trauma Data Bank Trauma Quality Improvement Program Mentoring for Excellence in Trauma Surgery Advanced Trauma Life Support Verification, Review, and Consultation Program for Hospitals ...

  2. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... 2016 Annual Meeting Women's Committee Mentorship Program Outside Activities ACS Archives Contact Us Quality Programs Quality Programs ... Quality in Geriatric Surgery Project Project Goals and Activities Stakeholder Organizations Project Team Resources News Contact Us ...

  3. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Accreditation Program for Breast Centers About NAPBC Accreditation Education NAPBC Standards Cancer Programs News Quality in Geriatric ... 4 and Recertification SSR Login MIPS Resources and Education Quality and Safety Conference Trauma Trauma Programs Trauma ...

  4. New Parent Support Program

    Science.gov (United States)

    ... preparation and guidance. View More Search All Installation Program Directory Find programs and services at your local installation. View a directory of installations Select a program or service Enter the name of an installation ...

  5. National Toxicology Program

    Science.gov (United States)

    ... at NTP Study Types Nominations to the Testing Program Study Results & Research Projects Areas of Research Data & ... on for decisions that matter. The National Toxicology Program provides the scientific basis for programs, activities, and ...

  6. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Meeting Women's Committee Mentorship Program Outside Activities ACS Archives Contact Us Quality Programs Quality Programs Overview About ... The Hartford Consensus News Coverage Stop the Bleed Archives and History Archives and History Archives and History ...

  7. Stop smoking support programs

    Science.gov (United States)

    Smokeless tobacco - stop smoking programs; Stop smoking techniques; Smoking cessation programs; Smoking cessation techniques ... You can find out about smoking cessation programs from: Your ... Your employer Your local health department The National Cancer ...

  8. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Conference Publications and Posters National Trauma System Injury Prevention and Control Quality and Safety Conference Quality and ... Safety Resources About the Patient Education Program The Recovery Room Choosing Wisely Educational Programs Educational Programs Educational ...

  9. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Data Bank Trauma Quality Improvement Program Mentoring for Excellence in Trauma Surgery Advanced Trauma Life Support Verification, ... Patients Medical Professionals Skills Programs Find a Treatment Center Patient Safety Resources About the Patient Education Program ...

  10. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Shop ( 0 ) Cart Donate American College of Surgeons Education Patients and Family Skills Programs Ostomy Home Skills Program Ostomy Home Skills Program Adult Ostomy Pediatric Ostomy Programa de Destrezas para manejo ...

  11. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... ACS Careers at ACS About ACS Career Types Working at ACS ... Education Patients and Family Skills Programs Ostomy Home Skills Program Ostomy Home Skills Program Adult Ostomy ...

  12. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... of Education ACS Education and Training Courses Publications Education Program Videos Contact Us Clinical Congress Clinical Congress 2017 ... Treatment Center Patient Safety Resources About the Patient Education Program The Recovery Room Choosing Wisely Educational Programs Educational ...

  13. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Program for Hospitals Trauma Systems Consultation Program Trauma Education Achieving Zero Preventable Deaths Conference Publications and Posters National Trauma System Injury ...

  14. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Life Support Verification, Review, and Consultation Program for Hospitals Trauma Systems Consultation Program Trauma Education Achieving Zero Preventable Deaths Conference Publications and Posters ...

  15. LANL Meteorology Program

    Energy Technology Data Exchange (ETDEWEB)

    Dewart, Jean Marie [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-02-09

    The goal of the Meteorology Program is to provide all routine meteorology measurements for LANL operational requirements. This report discusses the program, its routine operations, and other services.

  16. About the Clusters Program

    Science.gov (United States)

    The Environmental Technology Innovation Clusters Program advises cluster organizations, encourages collaboration between clusters, tracks U.S. environmental technology clusters, and connects EPA programs to cluster needs.

  17. [PIC Program Evaluation Forms.

    Science.gov (United States)

    Short, N. J.

    These 4 questionnaires are designed to elicit teacher and parent evaluations of the Prescriptive Instruction Center (PIC) program. Included are Teacher Evaluation of Program Effectiveness (14 items), M & M Evaluation of Program Implementation (methods and materials specialists; 11 items), Teacher Evaluation of Program Effectiveness--Case Study…

  18. Derivation of sorting programs

    Science.gov (United States)

    Varghese, Joseph; Loganantharaj, Rasiah

    1990-01-01

    Program synthesis for critical applications has become a viable alternative to program verification. Nested resolution and its extension are used to synthesize a set of sorting programs from their first order logic specifications. A set of sorting programs, such as, naive sort, merge sort, and insertion sort, were successfully synthesized starting from the same set of specifications.

  19. Stochastic Constraint Programming

    OpenAIRE

    Walsh, Toby

    2009-01-01

    To model combinatorial decision problems involving uncertainty and probability, we introduce stochastic constraint programming. Stochastic constraint programs contain both decision variables (which we can set) and stochastic variables (which follow a probability distribution). They combine together the best features of traditional constraint satisfaction, stochastic integer programming, and stochastic satisfiability. We give a semantics for stochastic constraint programs, and propose a number...

  20. Laser Programs Highlights 1998

    Energy Technology Data Exchange (ETDEWEB)

    Lowdermilk, H.; Cassady, C.

    1999-12-01

    This report covers the following topics: Commentary; Laser Programs; Inertial Confinement Fusion/National Ignition Facility (ICF/NIF); Atomic Vapor Laser Isotope Separation (AVLIS); Laser Science and Technology (LS&T); Information Science and Technology Program (IS&T); Strategic Materials Applications Program (SMAP); Medical Technology Program (MTP) and Awards.

  1. Program refinement in UNITY

    NARCIS (Netherlands)

    Vos, T.E.J.; Swierstra, S.D.

    2001-01-01

    Program refinement has received a lot of attention in the context of stepwise development of correct programs, since the introduction of transformational programming techniques by [Wir71, Hoa72, Ger75, BD77] in the seventies. This report presents a new framework of program refinement, that is

  2. Programs as Data Objects

    DEFF Research Database (Denmark)

    This book constitutes the refereed proceedings of the Second Symposium on Programs as Data Objects, PADO 2001, held in Aarhus, Denmark, in May 2001. The 14 revised full papers presented were carefully reviewed and selected from 30 submissions. Various aspects of looking at programs as data objects...... are covered from the point of view of program analysis, program transformation, computational complexity, etc....

  3. C++ Programming Language

    Science.gov (United States)

    Shaykhian, Gholam Ali

    2007-01-01

    C++ Programming Language: The C++ seminar covers the fundamentals of C++ programming language. The C++ fundamentals are grouped into three parts where each part includes both concept and programming examples aimed at for hands-on practice. The first part covers the functional aspect of C++ programming language with emphasis on function parameters and efficient memory utilization. The second part covers the essential framework of C++ programming language, the object-oriented aspects. Information necessary to evaluate various features of object-oriented programming; including encapsulation, polymorphism and inheritance will be discussed. The last part of the seminar covers template and generic programming. Examples include both user defined and standard templates.

  4. Generating Consistent Program Tutorials

    DEFF Research Database (Denmark)

    Vestdam, Thomas

    2002-01-01

    In this paper we present a tool that supports construction of program tutorials. A program tutorial provides the reader with an understanding of an example program by interleaving fragments of source code and explaining text. An example program can for example illustrate how to use a library...... or a framework. We present a means for specifying the fragments of a program that are to be in-lined in the tutorial text. These in-line fragments are defined by addressing named syntactical elements, such as classes and methods, but it is also possible to address individual code lines by labeling them...... with source markers. The tool helps ensuring consistency between program tutorial and example programs by extracting fragments of source code based on the fragment specifications and by detecting when a program tutorial is addressing program fragments that do not exist. The program tutorials are presented...

  5. Federal Wind Energy Program. Program summary. [USA

    Energy Technology Data Exchange (ETDEWEB)

    None

    1978-01-01

    The objective of the Federal Wind Energy Program is to accelerate the development of reliable and economically viable wind energy systems and enable the earliest possible commercialization of wind power. To achieve this objective for small and large wind systems requires advancing the technology, developing a sound industrial technology base, and addressing the non-technological issues which could deter the use of wind energy. This summary report outlines the projects being supported by the program through FY 1977 toward the achievement of these goals. It also outlines the program's general organization and specific program elements.

  6. Technology Commercialization Program 1991

    Energy Technology Data Exchange (ETDEWEB)

    1991-11-01

    This reference compilation describes the Technology Commercialization Program of the Department of Energy, Defense Programs. The compilation consists of two sections. Section 1, Plans and Procedures, describes the plans and procedures of the Defense Programs Technology Commercialization Program. The second section, Legislation and Policy, identifies legislation and policy related to the Program. The procedures for implementing statutory and regulatory requirements are evolving with time. This document will be periodically updated to reflect changes and new material.

  7. Multiobjective programming and planning

    CERN Document Server

    Cohon, Jared L

    2004-01-01

    This text takes a broad view of multiobjective programming, emphasizing the methods most useful for continuous problems. It reviews multiobjective programming methods in the context of public decision-making problems, developing each problem within a context that addresses practical aspects of planning issues. Topics include a review of linear programming, the formulation of the general multiobjective programming problem, classification of multiobjective programming methods, techniques for generating noninferior solutions, multiple-decision-making methods, multiobjective analysis of water reso

  8. Evaluasi Program English Club

    OpenAIRE

    Kurniawan, Mirdan; Herpratiwi, Herpratiwi; Purnomo, Eddy

    2015-01-01

    The purposes of this study were to 1) reveal students' perceptions about instructional English club program 2) reveal the students' perceptions about instructional English fun day program 3) reveal perception of students about instructional English wall magazine program. From the results of the study it was concluded that 1) students' perceptions of the instructional English club program was less advantages for students, 2) students' perceptions of instructional English fun day program have ...

  9. Inductive Temporal Logic Programming

    OpenAIRE

    Kolter, Robert

    2009-01-01

    We study the extension of techniques from Inductive Logic Programming (ILP) to temporal logic programming languages. Therefore we present two temporal logic programming languages and analyse the learnability of programs from these languages from finite sets of examples. In first order temporal logic the following topics are analysed: - How can we characterize the denotational semantics of programs? - Which proof techniques are best suited? - How complex is the learning task? In propositional ...

  10. Teaching Programming with Scratch

    OpenAIRE

    MIHALIČ, PETRA

    2014-01-01

    There are quite a few good programing languages and environments for teaching kids how to program. They help beginners learn basic programming constructs usually with help of interactive environment. In this thesis I will describe and compare a few of those languages and environments. Scratch is a language and programming environment that is also intended for learning programming using blocks that make writing complicated instructions easier and reduce beginners' difficulties with syntax erro...

  11. Programming Models in HPC

    Energy Technology Data Exchange (ETDEWEB)

    Shipman, Galen M. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-06-13

    These are the slides for a presentation on programming models in HPC, at the Los Alamos National Laboratory's Parallel Computing Summer School. The following topics are covered: Flynn's Taxonomy of computer architectures; single instruction single data; single instruction multiple data; multiple instruction multiple data; address space organization; definition of Trinity (Intel Xeon-Phi is a MIMD architecture); single program multiple data; multiple program multiple data; ExMatEx workflow overview; definition of a programming model, programming languages, runtime systems; programming model and environments; MPI (Message Passing Interface); OpenMP; Kokkos (Performance Portable Thread-Parallel Programming Model); Kokkos abstractions, patterns, policies, and spaces; RAJA, a systematic approach to node-level portability and tuning; overview of the Legion Programming Model; mapping tasks and data to hardware resources; interoperability: supporting task-level models; Legion S3D execution and performance details; workflow, integration of external resources into the programming model.

  12. Analyzing Array Manipulating Programs by Program Transformation

    Science.gov (United States)

    Cornish, J. Robert M.; Gange, Graeme; Navas, Jorge A.; Schachte, Peter; Sondergaard, Harald; Stuckey, Peter J.

    2014-01-01

    We explore a transformational approach to the problem of verifying simple array-manipulating programs. Traditionally, verification of such programs requires intricate analysis machinery to reason with universally quantified statements about symbolic array segments, such as "every data item stored in the segment A[i] to A[j] is equal to the corresponding item stored in the segment B[i] to B[j]." We define a simple abstract machine which allows for set-valued variables and we show how to translate programs with array operations to array-free code for this machine. For the purpose of program analysis, the translated program remains faithful to the semantics of array manipulation. Based on our implementation in LLVM, we evaluate the approach with respect to its ability to extract useful invariants and the cost in terms of code size.

  13. Revealing the programming process

    DEFF Research Database (Denmark)

    Bennedsen, Jens; Caspersen, Michael Edelgaard

    2005-01-01

    One of the most important goals of an introductory programming course is that the students learn a systematic approach to the development of computer programs. Revealing the programming process is an important part of this; however, textbooks do not address the issue -- probably because...... the textbook medium is static and therefore ill-suited to expose the process of programming. We have found that process recordings in the form of captured narrated programming sessions are a simple, cheap, and efficient way of providing the revelation.We identify seven different elements of the programming...

  14. The CHROME Honors Program

    Science.gov (United States)

    Wilson, Eleanor

    2002-01-01

    The CHROME Honors Program was designed as a two-week residential program for 9th and 1Oth grade students participating in CHROME clubs. The curriculum focused on the health sciences with instruction from: (1) the science and health curriculum of the Dozoretz National Program for Minorities in Applied Sciences (DNIMAS) Program of Norfolk State University (NSU); (2) the humanities curriculum of the NSU Honors Program; (3) NASA-related curriculum in human physiology. An Advisory Committee was formed to work with the Project Coordinator in the design of the summer program.

  15. Improved Nuclear Reactor and Shield Mass Model for Space Applications

    Science.gov (United States)

    Robb, Kevin

    2004-01-01

    New technologies are being developed to explore the distant reaches of the solar system. Beyond Mars, solar energy is inadequate to power advanced scientific instruments. One technology that can meet the energy requirements is the space nuclear reactor. The nuclear reactor is used as a heat source for which a heat-to-electricity conversion system is needed. Examples of such conversion systems are the Brayton, Rankine, and Stirling cycles. Since launch cost is proportional to the amount of mass to lift, mass is always a concern in designing spacecraft. Estimations of system masses are an important part in determining the feasibility of a design. I worked under Michael Barrett in the Thermal Energy Conversion Branch of the Power & Electric Propulsion Division. An in-house Closed Cycle Engine Program (CCEP) is used for the design and performance analysis of closed-Brayton-cycle energy conversion systems for space applications. This program also calculates the system mass including the heat source. CCEP uses the subroutine RSMASS, which has been updated to RSMASS-D, to estimate the mass of the reactor. RSMASS was developed in 1986 at Sandia National Laboratories to quickly estimate the mass of multi-megawatt nuclear reactors for space applications. In response to an emphasis for lower power reactors, RSMASS-D was developed in 1997 and is based off of the SP-100 liquid metal cooled reactor. The subroutine calculates the mass of reactor components such as the safety systems, instrumentation and control, radiation shield, structure, reflector, and core. The major improvements in RSMASS-D are that it uses higher fidelity calculations, is easier to use, and automatically optimizes the systems mass. RSMASS-D is accurate within 15% of actual data while RSMASS is only accurate within 50%. My goal this summer was to learn FORTRAN 77 programming language and update the CCEP program with the RSMASS-D model.

  16. Parallel programming with PCN

    Energy Technology Data Exchange (ETDEWEB)

    Foster, I.; Tuecke, S.

    1991-09-01

    PCN is a system for developing and executing parallel programs. It comprises a high-level programming language, a set of tools for developing and debugging programs in this language, and interfaces to Fortran and C that allow the reuse of existing code in multilingual parallel programs. Programs developed using PCN are portable across many different workstations, networks, and parallel computers. This document provides all the information required to develop parallel programs with the PCN programming system. It includes both tutorial and reference material. It also presents the basic concepts that underlie PCN, particularly where these are likely to be unfamiliar to the reader, and provides pointers to other documentation on the PCN language, programming techniques, and tools. PCN is in the public domain. The latest version of both the software and this manual can be obtained by anonymous FTP from Argonne National Laboratory at info.mcs.anl.gov.

  17. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Stereotactic Breast Biopsy Accreditation Program Cancer Programs Staff Information Children's Surgery Children's Surgery Children's Surgery Children's Surgery Verification ACS NSQIP Pediatric Fees and Invoices Quality and ...

  18. Health Programs for Veterans

    Science.gov (United States)

    ... Health Administration » Health Programs for Veterans Veterans Health Administration Health Programs for Veterans Beyond the doctors and ... families of patients receiving medical care at major military and VA medical centers Geriatrics & Extended Care Geriatric ...

  19. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... entire surgical team with quality, comprehensive education. The standardized interactive program has been developed by the American ... Ostomy Home Skills Hospital Quality Improvement Package The standardized interactive program has been developed by the American ...

  20. LOADING SIMULATION PROGRAM C

    Data.gov (United States)

    U.S. Environmental Protection Agency — LSPC is the Loading Simulation Program in C++, a watershed modeling system that includes streamlined Hydrologic Simulation Program Fortran (HSPF) algorithms for...

  1. Social marketing program sales.

    Science.gov (United States)

    1987-01-01

    This table presents data on social marketing program sales for projects that provide more than 5000 couple-years of protection. Cited are social marketing programs in Bangladesh, Costa Rica, Egypt, El Salvador, Guatemala, Honduras, India, Indonesia, Jamaica, Nepal, Pakistan, Peru, and Sri Lanka. Included in the table are data on program funding, product sales (generally condoms, pills, and foaming tablets), and couple-years of protection provided. Among the social marketing programs reporting particularly high couple-years of protection levels are the Bangladesh Family Planning Social Marketing Program (1,165,100), the Egyptian Family Planning Association's Family for the Future Program (732,200), India's Nirodh Marketing Program (2,225,000), and Pakistan's Social Marketing Contraceptive Program (280,000).

  2. Daily bowel care program

    Science.gov (United States)

    ... gov/ency/patientinstructions/000133.htm Daily bowel care program To use the sharing features on this page, ... Work with your health care provider. Basic Bowel Program Keeping active helps prevent constipation. Try to walk, ...

  3. NCLOS program 2010 update.

    Science.gov (United States)

    2013-06-01

    The North Carolina Level of Service (NCLOS) program is a planning-level highway capacity analysis tool : developed for NCDOT under a previous project. The program uses the operational methodologies in the 2010 : Highway Capacity Manual (HCM), along w...

  4. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... ACS Insurance Programs ACS Discount Programs FACS Resources Career Connection Update Your Profile Member Communities Leadership Opportunities ... Group Icons in Surgery Archives Catalog Contact Us Careers at ACS Careers at ACS Careers at ACS ...

  5. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... and Safety Conference Upcoming Educational Opportunities MBSAQIP News Contact Us Breast Disease National Accreditation Program for Breast Centers National Accreditation Program for Breast Centers About NAPBC ...

  6. Advanced General Dentistry Program.

    Science.gov (United States)

    Barnes, Douglas M.; And Others

    1988-01-01

    A description of the University of Maryland at Baltimore's one-year postdoctoral program in advanced general dentistry focuses on its goals and objectives, curriculum design, patient population, faculty and staff, finances, and program evaluation measures. (MSE)

  7. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... System Strategic Partnership Military Health System Strategic Partnership Military Health System Strategic Partnership About Excelsior Surgical Society ... Quality Programs Overview About Quality Programs ACS Leadership in Quality ACS Leadership in Quality Setting the ...

  8. Intergenerational Programs in Schools.

    Science.gov (United States)

    Cohen-Mansfield, Jiska; Jensen, Barbara

    2017-03-01

    This study examined the prevalence, types, and perceived impact of intergenerational programs in schools. Programs involving senior volunteers assisting children, or children participating in activities with older people were considered. Of the schools reached, 47% reported intergenerational programming. Thirty-three schools in the Tel-Aviv region participated in the study. Data were collected from 85 seniors, 26 teachers, and 20 coordinators. Assessments included program characteristics, program preparation, and perceived benefits and difficulties. Both programs were reported to have beneficial effects for seniors and to benefit children in the academic, social, and emotional domains. However, programs appeared to attract different types of volunteers and different degrees of volunteer commitment. Findings suggest that there is a need to pay additional attention to both participants' specific requests and needs and to the allocation of resources to improve the design and implementation of intergenerational programs.

  9. Modeling EERE deployment programs

    Energy Technology Data Exchange (ETDEWEB)

    Cort, K. A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Hostick, D. J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Belzer, D. B. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Livingston, O. V. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2007-11-01

    The purpose of the project was to identify and characterize the modeling of deployment programs within the EERE Technology Development (TD) programs, address possible improvements to the modeling process, and note gaps in knowledge for future research.

  10. LOADING SIMULATION PROGRAM C

    Science.gov (United States)

    LSPC is the Loading Simulation Program in C++, a watershed modeling system that includes streamlined Hydrologic Simulation Program Fortran (HSPF) algorithms for simulating hydrology, sediment, and general water quality

  11. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Accreditation Program for Breast Centers About NAPBC Accreditation Education NAPBC Standards News Quality in Geriatric Surgery Coalition ... 4 and Recertification SSR Login MIPS Resources and Education Quality and Safety Conference Trauma Trauma Programs Trauma ...

  12. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... and Invoices Quality and Safety Conference Bariatric Surgery Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program ...

  13. Superfund Contract Laboratory Program

    Science.gov (United States)

    The Contract Laboratory Program (CLP) is a national network of EPA personnel, commercial laboratories, and support contractors whose primary mission is to provide data of known and documented quality to the Superfund program.

  14. Automated preventive maintenance program

    Science.gov (United States)

    Cea, E. J.; Grieger, T. H.

    1971-01-01

    Maintenance program which is concise and inexpensive to operate adapts to almost any system that has a FORTRAN compiler. Program operates on a stored data base with an output consisting of scheduling information and various management reports.

  15. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Education Cancer Education Cancer Programs Conference: Creating a Culture of Quality CoC Events Quality Education Quality Education ... OR EHR Incentive Program Global Codes and Data Collection New Medicare Card Project Medicare Enrollment and Participation ...

  16. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... About Trauma Programs BleedingControl.org Trauma Quality Programs Violence Prevention National Trauma Data Bank Trauma Quality Improvement ... Benefits Current Openings Newsroom Newsroom Newsroom Press Releases Media Resources The FIRST Trial ACS Publications ACS in ...

  17. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Associate Fellows Residents Medical Students Affiliate Members ACS Insurance Programs ACS Discount Programs FACS Resources Career Connection ... and Awards Overview Scholarships, Fellowships, and Awards Overview Health Policy Scholarships Scholarships for International Surgeons Research Scholarships ...

  18. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... and Canada) International Fellows Associate Fellows Residents Medical Students Affiliate Members ACS Insurance Programs ACS Discount Programs FACS Resources Career Connection Update Your Profile Member Communities Leadership Opportunities ...

  19. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Medical Professionals Skills Programs Find a Treatment Center Patient Safety Resources About the Patient Education Program The Recovery ... Trauma CME Nora Institute Nora Institute for Surgical Patient Safety Nora Institute for Surgical Patient Safety Advanced Skills ...

  20. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Be a YFA Leader Meetings and Events YFA Mentor Programs Top 10 Reasons to Participate Resources Webinars ... National Trauma Data Bank Trauma Quality Improvement Program Mentoring for Excellence in Trauma Surgery Advanced Trauma Life ...

  1. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... My OR EHR Incentive Program Global Codes and Data Collection New Medicare Card Project Medicare Enrollment and Participation ... self-care checklist Evaluation (Complete the Ostomy Patient Survey . We need your opinion!) Program outcomes The ACS ...

  2. ICASE Computer Science Program

    Science.gov (United States)

    1985-01-01

    The Institute for Computer Applications in Science and Engineering computer science program is discussed in outline form. Information is given on such topics as problem decomposition, algorithm development, programming languages, and parallel architectures.

  3. Entrez Programming Utilities

    Data.gov (United States)

    U.S. Department of Health & Human Services — The Entrez Programming Utilities (E-utilities) are a set of eight server-side programs that provide a stable interface into the Entrez query and database system at...

  4. Veterans Choice Program

    Data.gov (United States)

    Department of Veterans Affairs — If you are already enrolled in VA health care, the Choice Program allows you to receive health care within your community. Using this program does NOT impact your...

  5. Crab Rationalization Permit Program

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Crab Rationalization Program (Program) allocates BSAI crab resources among harvesters, processors, and coastal communities. The North Pacific Fishery Management...

  6. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Member Fellows International Fellows Associate Fellows Residents Medical Students Affiliate Members Fees and Dues Realize the Potential ... and Canada) International Fellows Associate Fellows Residents Medical Students Affiliate Members ACS Insurance Programs ACS Discount Programs ...

  7. Coalbed Methane Outreach Program

    Science.gov (United States)

    Coalbed Methane Outreach Program, voluntary program seeking to reduce methane emissions from coal mining activities. CMOP promotes profitable recovery/use of coal mine methane (CMM), addressing barriers to using CMM instead of emitting it to atmosphere.

  8. HUD Program Income Limits

    Data.gov (United States)

    Department of Housing and Urban Development — Income limits used to determine the income eligibility of applicants for assistance under three programs authorized by the National Housing Act. These programs are...

  9. Astrophysics Program Overview; Briefing

    National Research Council Canada - National Science Library

    1998-01-01

    This is an overview briefing of the NAS Astrophysics programs. These program should lead the opening scientific frontiers and disseminate new knowledge, as the Hubble Space Telescope and Compton Gamma Ray Observatory are currently doing...

  10. Python to learn programming

    Science.gov (United States)

    Bogdanchikov, A.; Zhaparov, M.; Suliyev, R.

    2013-04-01

    Today we have a lot of programming languages that can realize our needs, but the most important question is how to teach programming to beginner students. In this paper we suggest using Python for this purpose, because it is a programming language that has neatly organized syntax and powerful tools to solve any task. Moreover it is very close to simple math thinking. Python is chosen as a primary programming language for freshmen in most of leading universities. Writing code in python is easy. In this paper we give some examples of program codes written in Java, C++ and Python language, and we make a comparison between them. Firstly, this paper proposes advantages of Python language in relation to C++ and JAVA. Then it shows the results of a comparison of short program codes written in three different languages, followed by a discussion on how students understand programming. Finally experimental results of students' success in programming courses are shown.

  11. Materials Sciences Programs

    Energy Technology Data Exchange (ETDEWEB)

    1977-01-01

    A compilation and index of the ERDA materials sciences program is presented. This compilation is intended for use by administrators, managers, and scientists to help coordinate research and as an aid in selecting new programs. (GHT)

  12. Parallel programming with PCN

    Energy Technology Data Exchange (ETDEWEB)

    Foster, I.; Tuecke, S.

    1991-12-01

    PCN is a system for developing and executing parallel programs. It comprises a high-level programming language, tools for developing and debugging programs in this language, and interfaces to Fortran and C that allow the reuse of existing code in multilingual parallel programs. Programs developed using PCN are portable across many different workstations, networks, and parallel computers. This document provides all the information required to develop parallel programs with the PCN programming system. In includes both tutorial and reference material. It also presents the basic concepts that underly PCN, particularly where these are likely to be unfamiliar to the reader, and provides pointers to other documentation on the PCN language, programming techniques, and tools. PCN is in the public domain. The latest version of both the software and this manual can be obtained by anonymous FTP from Argonne National Laboratory in the directory pub/pcn at info.mcs.anl.gov (c.f. Appendix A).

  13. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... for Excellence in Trauma Surgery Advanced Trauma Life Support Verification, Review, and Consultation Program for Hospitals Trauma Systems Consultation Program Trauma Education Achieving Zero Preventable Deaths ...

  14. Korea space program

    Science.gov (United States)

    Hong, Jai-Hak

    Though Korea's space activities are just in the infant stage, we are looking forward to joining the advanced countries in the space field. We have three on-going space programs: the KOREASAT Program, a sounding rocket program, and the KITSAT Program. And, we have three more programs that we are in the process of formulating: a small remote sensing satellite program, a data receiving station construction program, and the second generation KOREASAT program. We have several organizations which are involved with space-related activities: KARI, ETRI, SERI, and KAIST. KARI was founded in 1989 in accordance with the Aerospace Industry Development & Promotion Act for the purpose of conducting research on aicraft, satellites and scientific rockets, and supporting national aerospace development projects.

  15. NASA's Technology Utilization Program.

    Science.gov (United States)

    Farley, C. F.

    1972-01-01

    NASA's Technology Utilization Program is described, illustrating how it can be useful in achieving improved productivity, providing more jobs, solving public sector challenges, and strengthening the international competitive situation. Underlying the program is the fact that research and development conducted in NASA's aeronautics and space programs have generated much technical information concerning processes, products, or techniques which may be useful to engineers, doctors, or to others. The program is based on acquisition and publication, working with the user, and applications engineering.

  16. Reactive Programming in Java

    CERN Multimedia

    CERN. Geneva

    2017-01-01

    Reactive Programming in gaining a lot of excitement. Many libraries, tools, and frameworks are beginning to make use of reactive libraries. Besides, applications dealing with big data or high frequency data can benefit from this programming paradigm. Come to this presentation to learn about what reactive programming is, what kind of problems it solves, how it solves them. We will take an example oriented approach to learning the programming model and the abstraction.

  17. Photovoltaic systems. Program summary

    Energy Technology Data Exchange (ETDEWEB)

    None

    1978-12-01

    Each of the Department of Energy's Photovoltaic Systems Program projects funded and/or in existence during fiscal year 1978 (October 1, 1977 through September 30, 1978) are described. The project sheets list the contractor, principal investigator, and contract number and funding and summarize the programs and status. The program is divided into various elements: program assessment and integration, research and advanced development, technology development, system definition and development, system application experiments, and standards and performance criteria. (WHK)

  18. Joint Program Management Handbook

    Science.gov (United States)

    1994-12-01

    by that Service. The Program/Product Manger, the Program / Project Management Office , and, in turn, the functional elements of each Participating...manning document for the Program/ Project Management Office which will incorporate the positions to be occupied by representatives of the Participating...Participating Service Senior Representative(s) within the Program/ Project Management Office will: (1) Speak for his parent Service in all matters

  19. Building Technologies Program Multi-Year Program Plan Program Portfolio Management 2008

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2008-01-01

    Building Technologies Program Multi-Year Program Plan 2008 for program portfolio management, including the program portfolio management process, program analysis, performance assessment, stakeholder interactions, and cross-cutting issues.

  20. Recommendation: Comprehensive Programming.

    Science.gov (United States)

    Kelly, Judith

    1989-01-01

    This article summarizes recommendations of the Richardson Study regarding a comprehensive approach to programing for gifted students. Basic components of comprehensive programing are outlined, and seven steps deemed essential to program development and implementation are described, as implemented by the Pyramid Project in four school districts in…

  1. Modern programming language

    Science.gov (United States)

    Feldman, G. H.; Johnson, J. A.

    1980-01-01

    Structural-programming language is especially-tailored for producing assembly language programs for MODCOMP II and IV mini-computes. Modern programming language consists of set of simple and powerful control structures that include sequencing alternative selection, looping, sub-module linking, comment insertion, statement continuation, and compilation termination capabilities.

  2. Pressure simulation program

    NARCIS (Netherlands)

    Knoll, B.; Phaff, J.C.; Gids, W.F. de

    1995-01-01

    A computer program has been developed to predict the wind pressure coefficients Cp on facades and roofs of block shaped buildings. The program is based on fits of measured data, including wind shielding by obstacles and terrain roughness. Main advantages of the program are: it needs no expertise of

  3. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Ostomy Home Skills Program Ostomy Home Skills Program Adult Ostomy Pediatric Ostomy Programa de Destrezas para manejo Doméstico de Ostomía Ostomy Home Skills Program Adult Ostomy Pediatric Ostomy Programa de Destrezas para manejo ...

  4. Programming the BBC micro

    CERN Document Server

    Ferguson, John D; Macari, Louie; Williams, Peter H

    1983-01-01

    Programming the BBC Micro is a 12-chapter book that begins with a description of the BBC microcomputer, its peripheral, and faults. Subsequent chapters focus on practice in programming, program development, graphics, words, numbers, sound, bits, bytes, and assembly language. The interfacing, file handling, and detailed description of BBC microcomputer are also shown.

  5. Linear Projective Program Syntax

    NARCIS (Netherlands)

    Bergstra, J.A.; Bethke, I.

    2004-01-01

    Based on an extremely simple program notation more advanced program features can be developed in linear projective program syntax such as conditional statements, while loops, recursion, use of an evaluation stack, object classes, method calls etc. Taking care of a cumulative and bottom up

  6. Surgical Technology Program Guide.

    Science.gov (United States)

    Georgia Univ., Athens. Dept. of Vocational Education.

    This surgical technology program guide presents the standard curriculum for technical institutes in Georgia. The curriculum addresses the minimum competencies for a surgical technology program. The program guide is designed to relate primarily to the development of those skills needed by individuals in the field to provide services in the…

  7. Volunteer Mother Program.

    Science.gov (United States)

    Castellucci, Arthur, Ed.

    Five members of a school library administration class developed guidelines for a Volunteer Mother Program in public school libraries. Guidelines were stated for the following aspects of volunteer programs: (1) reasons for using volunteers; (2) introduction to the program; (3) recruitment; (4) qualifications; (5) amount of help needed; (6)…

  8. Engineering honours program

    NARCIS (Netherlands)

    Ir Antoine waal; Ir. Peter van Kollenburg

    2011-01-01

    In September 2009 the department of Engineering of Fontys University of Applied Sciences in the Netherlands has started a pilot honours program for excellent engineering students called PRogram OUstanding Development (PROUD). Aim of this program is to give those engineering students, who have the

  9. Special Milk Program

    Science.gov (United States)

    US Department of Agriculture, 2009

    2009-01-01

    The Special Milk Program provides milk to children in schools, child care institutions and eligible camps that do not participate in other Federal child nutrition meal service programs. The program reimburses schools and institutions for the milk they serve. In 2008, 4,676 schools and residential child care institutions participated, along with…

  10. Programming Languages RESONAN

    Indian Academy of Sciences (India)

    In this article we will briefly review various programming lan- ... notation should also match the type of algorithm. For example, programming languages to solve science and engineering problems should support arithmetic using wide ranging, high .... programs using a library of reusable 'components' was imperative.

  11. Customer Service Programming

    Science.gov (United States)

    1982-01-01

    Use of computer program STRCMACS has enabled Illinois Bell Telephone, a subsidiary of American Telephone and Telegraph to cut software development costs about 10 percent by reducing program maintenance and by allowing the department to bring other software into operation more quickly. It has also been useful in company training of programming staff.

  12. Weatherization and Intergovernmental Program - Weatherization Assistance Program

    Energy Technology Data Exchange (ETDEWEB)

    None

    2010-06-01

    The U.S. Department of Energy’s (DOE) Weatherization Assistance Program reduces energy costs for low-income households by increasing the energy efficiency of their homes, while ensuring their health and safety.

  13. Clean Coal Technology Programs: Program Update 2009

    Energy Technology Data Exchange (ETDEWEB)

    None

    2009-10-01

    The purpose of the Clean Coal Technology Programs: Program Update 2009 is to provide an updated status of the U.S. Department of Energy (DOE) commercial-scale demonstrations of clean coal technologies (CCT). These demonstrations have been performed under the Clean Coal Technology Demonstration Program (CCTDP), the Power Plant Improvement Initiative (PPII), and the Clean Coal Power Initiative (CCPI). Program Update 2009 provides: (1) a discussion of the role of clean coal technology demonstrations in improving the nation’s energy security and reliability, while protecting the environment using the nation’s most abundant energy resource—coal; (2) a summary of the funding and costs of the demonstrations; and (3) an overview of the technologies being demonstrated, along with fact sheets for projects that are active, recently completed, or recently discontinued.

  14. Scallop License Limitation Program (SLLP) Permit Program

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — A federal Scallop License Limitation Program (SLLP) license is required onboard any vessel deployed in scallop fisheries in Federal waters off Alaska (except for...

  15. Fuels from biomass program. Program summary

    Energy Technology Data Exchange (ETDEWEB)

    None

    1978-01-01

    An overview of the ongoing research, development, and demonstration efforts of the period Oct. 1, 1976--Sept. 30, 1977 is presented. Accomplishments are highlighted and plans for continued activities are included. Discussion is presented under the following section headings: the Fuels from Biomass Program; organizational and functional responsibilities; program funding; fiscal year 1977 summary tables; current projects: production and collection of biomass and conversion of biomass; bibliography; index of contractors; and, appendix--unsolicited proposal requirements. (JGB)

  16. Beginning programming for dummies

    CERN Document Server

    Wang, Wallace

    2011-01-01

    Do you think the programmers who work at your office are magical wizards who hold special powers that manipulate your computer? Believe it or not, anyone can learn how to write programs, and it doesn't take a higher math and science education to start. Beginning Programming for Dummies shows you how computer programming works without all the technical details or hard programming language. It explores the common parts of every computer programming language and how to write for multiple platforms like Windows, Mac OS X, or Linux. This easily accessible guide provides you with the tools

  17. C++ how to program

    CERN Document Server

    Deitel, Paul J

    2014-01-01

    This best-selling comprehensive text is aimed at readers with little or no programming experience. It teaches programming by presenting the concepts in the context of full working programs and takes an early-objects approach. The authors emphasize achieving program clarity through structured and object-oriented programming, software reuse and component-oriented software construction. The Ninth Edition encourages students to connect computers to the community, using the Internet to solve problems and make a difference in our world. All content has been carefully fine-tuned in response to a team of distinguished academic and industry reviewers.

  18. Programming in COBOL

    CERN Document Server

    Lancaster, G T

    2014-01-01

    Programming in COBOL is a simple yet concise how-to book that teaches the programming language in a short yet effective step-by-step manner, which can be easily understood by anyone with sufficient knowledge in information technology. Covering first the advantages of COBOL over other programming languages, the book discusses COBOL's divisions - identification, environment, procedure, and data, and then describes the testing of the COBOL source programs and program questions. The book is valuable for those who wish to learn basic COBOL language, but do not have the time to take manufacturers' o

  19. Program enhancements demonstrated

    Energy Technology Data Exchange (ETDEWEB)

    1980-08-11

    Enhancements to the Gastran Program for simulation of steady-state gathering systems are outlined. The operation of the modifications, as well as 2 new major engineering programs (Pipetran and Matbal), is discussed as an example of useable software programs to assist oil and gas production. Pipetran is a program that utilizes the best available multiphase flow correlations in a network structure for design and analysis of multiphase flow gathering systems. Matbal is a general purpose oil material balance program for obtaining reservoir performance information at a reasonable cost for all reservoirs with pressure below the bubble point.

  20. Mini Project Programming Exams

    DEFF Research Database (Denmark)

    Nørmark, Kurt; Thomsen, Lone Leth; Torp, Kristian

    2008-01-01

    A number of different types of final programming exams used or considered at the Department of Computer Science, Aalborg University, are identified and analyzed. Based on this analysis, a new type of programming exam is introduced called a Mini Project Programming (MIP) exam. MIP is a group......-based programming assignment that is intended as a medium-scale programming effort followed by a final oral exam. MIP is characterized and compared to existing types of final programming exams by use of a number of independent criteria. The paper motivates the MIP approach and reports on our experience over four...... years. The MIP exam is a compromise between (1) a long problem-based project exam and (2) a short oral or written programming exam. It is concluded that the strengths of MIP are the high degree of realism in the exam assignment and comprehensiveness relative to the course syllabus. The main challenge...

  1. Functional Programming in R

    DEFF Research Database (Denmark)

    Mailund, Thomas

    2017-01-01

    Master functions and discover how to write functional programs in R. In this book, you'll make your functions pure by avoiding side-effects; you’ll write functions that manipulate other functions, and you’ll construct complex functions using simpler functions as building blocks. In Functional...... Programming in R, you’ll see how we can replace loops, which can have side-effects, with recursive functions that can more easily avoid them. In addition, the book covers why you shouldn't use recursion when loops are more efficient and how you can get the best of both worlds. Functional programming...... is a style of programming, like object-oriented programming, but one that focuses on data transformations and calculations rather than objects and state. Where in object-oriented programming you model your programs by describing which states an object can be in and how methods will reveal or modify...

  2. Functional Programming in R

    DEFF Research Database (Denmark)

    Mailund, Thomas

    Master functions and discover how to write functional programs in R. In this book, you'll make your functions pure by avoiding side-effects; you’ll write functions that manipulate other functions, and you’ll construct complex functions using simpler functions as building blocks. In Functional...... Programming in R, you’ll see how we can replace loops, which can have side-effects, with recursive functions that can more easily avoid them. In addition, the book covers why you shouldn't use recursion when loops are more efficient and how you can get the best of both worlds. Functional programming...... is a style of programming, like object-oriented programming, but one that focuses on data transformations and calculations rather than objects and state. Where in object-oriented programming you model your programs by describing which states an object can be in and how methods will reveal or modify...

  3. Functional Programming in R

    DEFF Research Database (Denmark)

    Mailund, Thomas

    is a style of programming, like object-oriented programming, but one that focuses on data transformations and calculations rather than objects and state. Where in object-oriented programming you model your programs by describing which states an object can be in and how methods will reveal or modify......Master functions and discover how to write functional programs in R. In this book, you'll make your functions pure by avoiding side-effects; you’ll write functions that manipulate other functions, and you’ll construct complex functions using simpler functions as building blocks. In Functional...... Programming in R, you’ll see how we can replace loops, which can have side-effects, with recursive functions that can more easily avoid them. In addition, the book covers why you shouldn't use recursion when loops are more efficient and how you can get the best of both worlds. Functional programming...

  4. Utility Green Pricing Programs: A Statistical Analysis of Program Effectiveness

    Energy Technology Data Exchange (ETDEWEB)

    Wiser, R.; Olson, S.; Bird, L.; Swezey, B.

    2004-02-01

    This report analyzes actual utility green pricing program data to provide further insight into which program features might help maximize both customer participation in green pricing programs and the amount of renewable energy purchased by customers in those programs.

  5. Aspect-Oriented Programming

    Science.gov (United States)

    Elrad, Tzilla (Editor); Filman, Robert E. (Editor); Bader, Atef (Editor)

    2001-01-01

    Computer science has experienced an evolution in programming languages and systems from the crude assembly and machine codes of the earliest computers through concepts such as formula translation, procedural programming, structured programming, functional programming, logic programming, and programming with abstract data types. Each of these steps in programming technology has advanced our ability to achieve clear separation of concerns at the source code level. Currently, the dominant programming paradigm is object-oriented programming - the idea that one builds a software system by decomposing a problem into objects and then writing the code of those objects. Such objects abstract together behavior and data into a single conceptual and physical entity. Object-orientation is reflected in the entire spectrum of current software development methodologies and tools - we have OO methodologies, analysis and design tools, and OO programming languages. Writing complex applications such as graphical user interfaces, operating systems, and distributed applications while maintaining comprehensible source code has been made possible with OOP. Success at developing simpler systems leads to aspirations for greater complexity. Object orientation is a clever idea, but has certain limitations. We are now seeing that many requirements do not decompose neatly into behavior centered on a single locus. Object technology has difficulty localizing concerns invoking global constraints and pandemic behaviors, appropriately segregating concerns, and applying domain-specific knowledge. Post-object programming (POP) mechanisms that look to increase the expressiveness of the OO paradigm are a fertile arena for current research. Examples of POP technologies include domain-specific languages, generative programming, generic programming, constraint languages, reflection and metaprogramming, feature-oriented development, views/viewpoints, and asynchronous message brokering. (Czarneclu and

  6. Programming Scala Scalability = Functional Programming + Objects

    CERN Document Server

    Wampler, Dean

    2009-01-01

    Learn how to be more productive with Scala, a new multi-paradigm language for the Java Virtual Machine (JVM) that integrates features of both object-oriented and functional programming. With this book, you'll discover why Scala is ideal for highly scalable, component-based applications that support concurrency and distribution. Programming Scala clearly explains the advantages of Scala as a JVM language. You'll learn how to leverage the wealth of Java class libraries to meet the practical needs of enterprise and Internet projects more easily. Packed with code examples, this book provides us

  7. Programming in biomolecular computation

    DEFF Research Database (Denmark)

    Hartmann, Lars Røeboe; Jones, Neil; Simonsen, Jakob Grue

    2011-01-01

    Our goal is to provide a top-down approach to biomolecular computation. In spite of widespread discussion about connections between biology and computation, one question seems notable by its absence: Where are the programs? We identify a number of common features in programming that seem...... conspicuously absent from the literature on biomolecular computing; to partially redress this absence, we introduce a model of computation that is evidently programmable, by programs reminiscent of low-level computer machine code; and at the same time biologically plausible: its functioning is defined...... by a single and relatively small set of chemical-like reaction rules. Further properties: the model is stored-program: programs are the same as data, so programs are not only executable, but are also compilable and interpretable. It is universal: all computable functions can be computed (in natural ways...

  8. Programming in biomolecular computation

    DEFF Research Database (Denmark)

    Hartmann, Lars Røeboe; Jones, Neil; Simonsen, Jakob Grue

    2010-01-01

    Our goal is to provide a top-down approach to biomolecular computation. In spite of widespread discussion about connections between biology and computation, one question seems notable by its absence: Where are the programs? We introduce a model of computation that is evidently programmable......, by programs reminiscent of low-level computer machine code; and at the same time biologically plausible: its functioning is defined by a single and relatively small set of chemical-like reaction rules. Further properties: the model is stored-program: programs are the same as data, so programs are not only...... in a strong sense: a universal algorithm exists, that is able to execute any program, and is not asymptotically inefficient. A prototype model has been implemented (for now in silico on a conventional computer). This work opens new perspectives on just how computation may be specified at the biological level....

  9. MIDI Programming in Scheme

    DEFF Research Database (Denmark)

    Nørmark, Kurt

    2010-01-01

    makes it possible to carry out systematic modifications and transformations of MIDI contents with use of pure functional programming. Side by side with the XML-inspired MIDI language, the paper describes an Emacs-based, textual programming environment that supports the MIDI programming process....... The programming environment also supports a variety of interactive features - similar to MIDI sequencers - but restricted to a textual representation of the music. The main contributions of the work are considered to be (1) An accumulated MIDI function library, which can transform MIDI files in many non......-trivial ways; (2) A proposed working process alternating between creative mode and programmatic editing mode within a MIDI programming environment; and (3) A textual MIDI programming environment with embedded support of many interactive, MIDI-related functionalities....

  10. Functional Programming in R

    DEFF Research Database (Denmark)

    Mailund, Thomas

    that state, in functional programming you model programs by describing how functions translate input data to output data. Functions themselves are considered to be data you can manipulate and much of the strength of functional programming comes from manipulating functions; that is, building more complex......Master functions and discover how to write functional programs in R. In this book, you'll make your functions pure by avoiding side-effects; you’ll write functions that manipulate other functions, and you’ll construct complex functions using simpler functions as building blocks. In Functional...... Programming in R, you’ll see how we can replace loops, which can have side-effects, with recursive functions that can more easily avoid them. In addition, the book covers why you shouldn't use recursion when loops are more efficient and how you can get the best of both worlds. Functional programming...

  11. A nursing bioethics program.

    Science.gov (United States)

    Albrizio, M A; Ozuna, J; Mattheis, R; Saunders, J

    1992-01-01

    In 1985 the Seattle Veterans' Administration Medical Center nursing service implemented a nursing program for bioethics with three goals: (1) to expand the nurse's knowledge of bioethical principles, (2) to develop the nurse's ability and confidence in analyzing bioethical dilemmas, and (3) to increase bioethical application at the bedside. Two psychosocial clinical nurse specialists (CNSs) led this highly successful nursing program that prepared nurses to more actively and responsibly participate in bioethical decision making within the medical center. The program offers an annual workshop for new members, holds a monthly discussion group, conducts a yearly enrichment program, and completes an annual evaluation report. This article describes nursing service bioethics program from planning through evaluation and the role of the CNS as program coordinator, facilitator, and educator in the expanding field of bioethics.

  12. Test-driven programming

    Science.gov (United States)

    Georgiev, Bozhidar; Georgieva, Adriana

    2013-12-01

    In this paper, are presented some possibilities concerning the implementation of a test-driven development as a programming method. Here is offered a different point of view for creation of advanced programming techniques (build tests before programming source with all necessary software tools and modules respectively). Therefore, this nontraditional approach for easier programmer's work through building tests at first is preferable way of software development. This approach allows comparatively simple programming (applied with different object-oriented programming languages as for example JAVA, XML, PYTHON etc.). It is predictable way to develop software tools and to provide help about creating better software that is also easier to maintain. Test-driven programming is able to replace more complicated casual paradigms, used by many programmers.

  13. Meteorological Monitoring Program

    Energy Technology Data Exchange (ETDEWEB)

    Hancock, H.A. Jr. [ed.; Parker, M.J.; Addis, R.P.

    1994-09-01

    The purpose of this technical report is to provide a comprehensive, detailed overview of the meteorological monitoring program at the Savannah River Site (SRS) near Aiken, South Carolina. The principle function of the program is to provide current, accurate meteorological data as input for calculating the transport and diffusion of any unplanned release of an atmospheric pollutant. The report is recommended for meteorologists, technicians, or any personnel who require an in-depth understanding of the meteorological monitoring program.

  14. Programming Language Pragmatics

    CERN Document Server

    Scott, Michael L

    2009-01-01

    Programming Language Pragmatics is the most comprehensive programming language textbook available today. Taking the perspective that language design and language implementation are tightly interconnected, and that neither can be fully understood in isolation, this critically acclaimed and bestselling book has been thoroughly updated to cover the most recent developments in programming language design. With a new chapter on run-time program management and expanded coverage of concurrency, this new edition provides both students and professionals alike with a solid understanding of the most impo

  15. Constraints in Genetic Programming

    Science.gov (United States)

    Janikow, Cezary Z.

    1996-01-01

    Genetic programming refers to a class of genetic algorithms utilizing generic representation in the form of program trees. For a particular application, one needs to provide the set of functions, whose compositions determine the space of program structures being evolved, and the set of terminals, which determine the space of specific instances of those programs. The algorithm searches the space for the best program for a given problem, applying evolutionary mechanisms borrowed from nature. Genetic algorithms have shown great capabilities in approximately solving optimization problems which could not be approximated or solved with other methods. Genetic programming extends their capabilities to deal with a broader variety of problems. However, it also extends the size of the search space, which often becomes too large to be effectively searched even by evolutionary methods. Therefore, our objective is to utilize problem constraints, if such can be identified, to restrict this space. In this publication, we propose a generic constraint specification language, powerful enough for a broad class of problem constraints. This language has two elements -- one reduces only the number of program instances, the other reduces both the space of program structures as well as their instances. With this language, we define the minimal set of complete constraints, and a set of operators guaranteeing offspring validity from valid parents. We also show that these operators are not less efficient than the standard genetic programming operators if one preprocesses the constraints - the necessary mechanisms are identified.

  16. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Education Cancer Education Cancer Programs Conference: Creating a Culture of Quality CoC Events Quality Education Quality Education Quality Education Quality and Safety Conference ...

  17. Ostomy Home Skills Program

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    Full Text Available ... Health Records (EHR) Incentive Program Physician Quality Reporting System Value-Based Payment Modifier ... Practice Management Practice Management Practice Management CPT Coding Bulletin Articles ...

  18. Construction program management

    CERN Document Server

    Delaney, Joseph

    2013-01-01

    Although construction is one of the largest industries in the United States, it lags behind other industries in its implementation of modern management techniques such as those contained in the Standard for Program Management (the Standard) by the Project Management Institute (PMI(R)). Construction Program Management details the successful use of the PMI(R) approach for the construction of capital programs. It demonstrates, through case studies, how implementation of PMI's set of tools and techniques can improve the chances of program success. Exploring tactical and strategic management method

  19. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Maintenance of Certification Quality Quality Quality Electronic Health Records (EHR) Incentive Program ... Practice Management Practice Management Practice Management CPT Coding Bulletin Articles ...

  20. Program management model study

    Science.gov (United States)

    Connelly, J. J.; Russell, J. E.; Seline, J. R.; Sumner, N. R., Jr.

    1972-01-01

    Two models, a system performance model and a program assessment model, have been developed to assist NASA management in the evaluation of development alternatives for the Earth Observations Program. Two computer models were developed and demonstrated on the Goddard Space Flight Center Computer Facility. Procedures have been outlined to guide the user of the models through specific evaluation processes, and the preparation of inputs describing earth observation needs and earth observation technology. These models are intended to assist NASA in increasing the effectiveness of the overall Earth Observation Program by providing a broader view of system and program development alternatives.

  1. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Donate American College of Surgeons Education Patients and Family Skills Programs ... The Ostomy Home Skills Kit supports patients with educational and simulation materials to learn ...

  2. Veterinary Services Program

    Data.gov (United States)

    Federal Laboratory Consortium — Mission:To provide quality veterinary medical care and environmental enrichment programs for all animals, representing nine different species.To provide guidance for...

  3. Privacy Training Program

    Science.gov (United States)

    Recognizing that training and awareness are critical to protecting agency Personally Identifiable Information (PII), the EPA is developing online training for privacy contacts in its programs and regions.

  4. An extended day program

    Directory of Open Access Journals (Sweden)

    Ševkušić-Mandić Slavica G.

    2002-01-01

    Full Text Available The paper presents the results of a pilot project evaluation, carried out as an action investigation whose aim was to provide a better quality extended day for primary school students. The project included the training of teachers involved in extended day program, designing of special activities performed by teachers with children once a week as well as changes and equipping of premises where children stay. The aims of the program were conception and performance of activities in a less formal way than during regular instructional days, linking of learning at school and acquired knowledge to everyday experiences, and work on contents contributing to the development of child's interests and creativity. The program was accomplished in a Belgrade primary school during the 2001/2002 academic year, comprising students of 1st and 2nd grades (N=77. The effects of the program were monitored throughout the academic year (observation and teachers' reports on accomplished workshops and at the end of the academic year (teachers and students' opinions of the program, academic achievement and creativity of students attending the extended day program compared with students not attending it. Findings about positive effects of the program on students' broadening of interests and willingness to express themselves creatively, indicate unequivocally that there is a need for developing special extended day programs. The extended day program is an opportunity for school to exert greater educational influence that has yet to be tapped.

  5. Tribal Waste Management Program

    Science.gov (United States)

    The EPA’s Tribal Waste Management Program encourages environmentally sound waste management practices that promote resource conservation through recycling, recovery, reduction, clean up, and elimination of waste.

  6. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Program Federal Legislation Federal Legislation Federal Legislation Health Care Reform Summary Letters on Health Care Reform Medicare Physician Payment Medical Liability Reform GME ...

  7. Programming language structures

    CERN Document Server

    Organick, Elliott Irving; Plummer, Robert P

    1978-01-01

    Programming Language Structures deals with the structures of programming languages and introduces the reader to five important programming languages: Algol, Fortran, Lisp, Snobol, and Pascal. The fundamental similarities and differences among these languages are discussed. A unifying framework is constructed that can be used to study the structure of other languages, such as Cobol, PL/I, and APL. Several of the tools and methodologies needed to construct large programs are also considered.Comprised of 10 chapters, this book begins with a summary of the relevant concepts and principles about al

  8. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Global Codes and Data Collection New Medicare Card Project Medicare Enrollment and ... Quality Electronic Health Records (EHR) Incentive Program Physician Quality Reporting ...

  9. Transit Benefit Program Data -

    Data.gov (United States)

    Department of Transportation — This data set contains information about any US government agency participating in the transit benefits program, funding agreements, individual participating Federal...

  10. Introduction to dynamic programming

    CERN Document Server

    Cooper, Leon; Rodin, E Y

    1981-01-01

    Introduction to Dynamic Programming provides information pertinent to the fundamental aspects of dynamic programming. This book considers problems that can be quantitatively formulated and deals with mathematical models of situations or phenomena that exists in the real world.Organized into 10 chapters, this book begins with an overview of the fundamental components of any mathematical optimization model. This text then presents the details of the application of dynamic programming to variational problems. Other chapters consider the application of dynamic programming to inventory theory, Mark

  11. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Opportunities JACS CME CME State Requirements Contact Accreditation, Verification, and Validation Accreditation, Verification, and Validation Programs Accreditation, Verification, and ...

  12. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Pediatric Fees and Invoices Quality and Safety Conference Bariatric Surgery Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program Metabolic and Bariatric ...

  13. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... CME Accreditation CME Joint Providership Program Verification of Knowledge and Skills ... Practice Management Workshops Patients and Family Patient Education Patient Education ...

  14. Database Programming Languages

    DEFF Research Database (Denmark)

    This volume contains the proceedings of the 11th International Symposium on Database Programming Languages (DBPL 2007), held in Vienna, Austria, on September 23-24, 2007. DBPL 2007 was one of 15 meetings co-located with VLBD (the International Conference on Very Large Data Bases). DBPL continues...... to present the very best work at the intersection of dataase and programming language research. The proceedings include a paper based on the invited talk by Wenfie Fan and the 16 contributed papers that were selected by at least three members of the program committee. In addition, the program commitee sought...

  15. Parallel programming with PCN

    Energy Technology Data Exchange (ETDEWEB)

    Foster, I.; Tuecke, S.

    1993-01-01

    PCN is a system for developing and executing parallel programs. It comprises a high-level programming language, tools for developing and debugging programs in this language, and interfaces to Fortran and Cthat allow the reuse of existing code in multilingual parallel programs. Programs developed using PCN are portable across many different workstations, networks, and parallel computers. This document provides all the information required to develop parallel programs with the PCN programming system. It includes both tutorial and reference material. It also presents the basic concepts that underlie PCN, particularly where these are likely to be unfamiliar to the reader, and provides pointers to other documentation on the PCN language, programming techniques, and tools. PCN is in the public domain. The latest version of both the software and this manual can be obtained by anonymous ftp from Argonne National Laboratory in the directory pub/pcn at info.mcs. ani.gov (cf. Appendix A). This version of this document describes PCN version 2.0, a major revision of the PCN programming system. It supersedes earlier versions of this report.

  16. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Online Guide to Choosing a Surgical Residency Practice Management Workshops Patients and Family Patient Education Patient Education Patients Medical Professionals Skills Programs Find ...

  17. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Surgical Skills Curriculum Cancer Education Cancer Education Cancer Education Cancer Programs Conference: Creating a Culture of Quality CoC Events Quality Education Quality Education ...

  18. The standard for program management

    CERN Document Server

    2017-01-01

    The Standard for Program Management – Fourth Edition differs from prior editions by focusing on the principles of good program management. Program activities have been realigned to program lifecycle phases rather than topics, and the first section was expanded to address the key roles of program manager, program sponsor and program management office. It has also been updated to better align with PMI’s Governance of Portfolios, Programs, and Projects: A Practice Guide.

  19. The Veterans Choice Program (VCP): Program Implementation

    Science.gov (United States)

    2017-01-05

    to VACAA and challenges encountered during implantation of the law. Table 1 provides major highlights pertaining to the Veterans Choice Program (VCP...outpatient medical, surgical, and mental healthcare; pharmaceuticals; pregnancy and delivery services; dental care; and durable medical equipment, and

  20. Transgenerational developmental programming.

    Science.gov (United States)

    Aiken, Catherine E; Ozanne, Susan E

    2014-01-01

    The concept of developmental programming suggests that the early life environment influences offspring characteristics in later life, including the propensity to develop diseases such as the metabolic syndrome. There is now growing evidence that the effects of developmental programming may also manifest in further generations without further suboptimal exposure. This review considers the evidence, primarily from rodent models, for effects persisting to subsequent generations, and evaluates the mechanisms by which developmental programming may be transmitted to further generations. In particular, we focus on the potential role of the intrauterine environment in contributing to a developmentally programmed phenotype in subsequent generations. The literature was systematically searched at http://pubmed.org and http://scholar.google.com to identify published findings regarding transgenerational (F2 and beyond) developmental programming effects in human populations and animal models. Transmission of programming effects is often viewed as a form of epigenetic inheritance, either via the maternal or paternal line. Evidence exists for both germline and somatic inheritance of epigenetic modifications which may be responsible for phenotypic changes in further generations. However, there is increasing evidence for the role of both extra-genomic components of the zygote and the interaction of the developing conceptus with the intrauterine environment in propagating programming effects. The contribution of a suboptimal reproductive tract environment or maternal adaptations to pregnancy may be critical to inheritance of programming effects via the maternal line. As the effects of age exacerbate the programmed metabolic phenotype, advancing maternal age may increase the likelihood of developmental programming effects being transmitted to further generations. We suggest that developmental programming effects could be propagated through the maternal line de novo in generations

  1. A Silent Safety Program

    Science.gov (United States)

    Goodin, James Ronald

    2006-01-01

    NASA's Columbia Accident Investigation Board (CAIB) referred 8 times to the NASA "Silent Safety Program." This term, "Silent Safety Program" was not an original observation but first appeared in the Rogers Commission's Investigation of the Challenger Mishap. The CAIB on page 183 of its report in the paragraph titled 'Encouraging Minority Opinion,' stated "The Naval Reactor Program encourages minority opinions and "bad news." Leaders continually emphasize that when no minority opinions are present, the responsibility for a thorough and critical examination falls to management. . . Board interviews revealed that it is difficult for minority and dissenting opinions to percolate up through the agency's hierarchy. . ." The first question and perhaps the only question is - what is a silent safety program? Well, a silent safety program may be the same as the dog that didn't bark in Sherlock Holmes' "Adventure of the Silver Blaze" because system safety should behave as a devil's advocate for the program barking on every occasion to insure a critical review inclusion. This paper evaluates the NASA safety program and provides suggestions to prevent the recurrence of the silent safety program alluded to in the Challenger Mishap Investigation. Specifically targeted in the CAM report, "The checks and balances the safety system was meant to provide were not working." A silent system safety program is not unique to NASA but could emerge in any and every organization. Principles developed by Irving Janis in his book, Groupthink, listed criteria used to evaluate an organization's cultural attributes that allows a silent safety program to evolve. If evidence validates Jams's criteria, then Jams's recommendations for preventing groupthink can also be used to improve a critical evaluation and thus prevent the development of a silent safety program.

  2. Building Technologies Program Multi-Year Program Plan Program Overview 2008

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2008-01-01

    Building Technologies Program Multi-Year Program Plan Program Overview 2008, including market overview and federal role, program vision, mission, design and structure, and goals and multi-year targets.

  3. Multiprocessor programming environment

    Energy Technology Data Exchange (ETDEWEB)

    Smith, M.B.; Fornaro, R.

    1988-12-01

    Programming tools and techniques have been well developed for traditional uniprocessor computer systems. The focus of this research project is on the development of a programming environment for a high speed real time heterogeneous multiprocessor system, with special emphasis on languages and compilers. The new tools and techniques will allow a smooth transition for programmers with experience only on single processor systems.

  4. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Ostomy Home Skills Program Adult Ostomy Pediatric Ostomy Programa de Destrezas para manejo Doméstico de Ostomía Ostomy Home Skills Program Adult Ostomy Pediatric Ostomy Programa de Destrezas para manejo Doméstico de Ostomía The Ostomy Home Skills Kit ...

  5. NVLAP calibration laboratory program

    Energy Technology Data Exchange (ETDEWEB)

    Cigler, J.L.

    1993-12-31

    This paper presents an overview of the progress up to April 1993 in the development of the Calibration Laboratories Accreditation Program within the framework of the National Voluntary Laboratory Accreditation Program (NVLAP) at the National Institute of Standards and Technology (NIST).

  6. Learning Apex programming

    CERN Document Server

    Kaufman, Matt

    2015-01-01

    If you are a developer who has some object-oriented programming experience, Learning Apex Programming is the perfect book for you. This book is most appropriate for developers who wish to gain an understanding of the Force.com platform and how to use Apex to create business applications.

  7. FIESTA; Minority Television Programming.

    Science.gov (United States)

    Marshall, Wes; And Others

    The suggestions for planning, running, and evaluating minority television programing presented in this handbook are based on the experience and example of the FIESTA project (Tucson, Arizona). After initiating the reader into the topic of minority programing, the document disucsses the following topics: broadcast research, origins of the FIESTA…

  8. Teaching Preparation Program (TPP).

    Science.gov (United States)

    California Univ., Los Angeles. Dept. of Geography.

    Because most graduate geography students will engage in professional teaching activities, the Teaching Preparation Program of UCLA's department of geography is viewed as an important part of graduate training. The program, co-directed by a graduate student and faculty member, is available to all graduate students on a voluntary basis and consists…

  9. Image-Enhancement Program

    Science.gov (United States)

    Matthews, Christine G.; Stacy, Kathryn

    1993-01-01

    ENHANCETOOL computer program has capabilities for interactive enhancement of digital images. Includes particularly useful combination of algorithms not existing in single interactive program. Software package also provides means through which additional image-enhancement algorithms easily integrated and made available to user. Written in C Language.

  10. Programs That Educate.

    Science.gov (United States)

    Kealey, Robert J., Comp.

    The essays in this collection reflect on effective practices conducted in Catholic schools. Essays were written by participants in the 2000 principals' academy. Under "Section 1: Religious Education" are the following essays: "Kingdom Builders" (Sr. M. Joseph); "Sacramental Programs, Parish Programs" (J. Thaler); and…

  11. Optimal Quadratic Programming Algorithms

    CERN Document Server

    Dostal, Zdenek

    2009-01-01

    Quadratic programming (QP) is one technique that allows for the optimization of a quadratic function in several variables in the presence of linear constraints. This title presents various algorithms for solving large QP problems. It is suitable as an introductory text on quadratic programming for graduate students and researchers

  12. Modeling EERE Deployment Programs

    Energy Technology Data Exchange (ETDEWEB)

    Cort, K. A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Hostick, D. J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Belzer, D. B. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Livingston, O. V. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2007-11-01

    This report compiles information and conclusions gathered as part of the “Modeling EERE Deployment Programs” project. The purpose of the project was to identify and characterize the modeling of deployment programs within the EERE Technology Development (TD) programs, address possible improvements to the modeling process, and note gaps in knowledge in which future research is needed.

  13. Air Pollution Training Programs.

    Science.gov (United States)

    Public Health Service (DHEW), Rockville, MD.

    This catalog lists the universities, both supported and not supported by the Division of Air Pollution, which offer graduate programs in the field of air pollution. The catalog briefly describes the programs and their entrance requirements, the requirements, qualifications and terms of special fellowships offered by the Division of Air Pollution.…

  14. National Agrologistics Program

    NARCIS (Netherlands)

    Langelaan, H.C.; Ravensbergen, P.

    2015-01-01

    The goal of the National Agrologistics Program is to define public policy measures that contribute to accomplish the potential of exporting agro-products, which will result in a transforming legacy for the sector. The horizon of this Program is the year 2030.

  15. [Early stimulation > programs evaluation].

    Science.gov (United States)

    Bonnier, C

    2007-09-01

    Early intervention include educational and neuroprotection strategies. Early educational strategies are based on the cerebral plasticity concept. Neuroprotection, initially reserved for molecules preventing cell death phenomena, can be extended now to all actions promoting harmonious development and preventing handicaps, and include organisational, therapeutic and environmental aspects. Early stimulation programs have been first devised in United States for vulnerable children who belong to an unfavorable socio-economic category ; positive effects were recorded in school failure rates and social problems ; programs have also been launched in several countries for premature infants and infants with a low birth weight, population exposed to a high risk of deficiencies. The programs are targetted either to the child, or to the parents, or combined to provide assistance for both the child and the parents. The programs given the best evaluation are NIDCAP Program in Sweden (Newborn Individualized Developmental Care and Assessment Program), intended for babies neonatal intensive care units, then a longitudinal, multisite program, known as IHDP (Infant Health and Development Program). It was launched in United States for infants stimulation is maintained and when mothers have a low level of education.

  16. Flexible Animation Computer Program

    Science.gov (United States)

    Stallcup, Scott S.

    1990-01-01

    FLEXAN (Flexible Animation), computer program animating structural dynamics on Evans and Sutherland PS300-series graphics workstation with VAX/VMS host computer. Typical application is animation of spacecraft undergoing structural stresses caused by thermal and vibrational effects. Displays distortions in shape of spacecraft. Program displays single natural mode of vibration, mode history, or any general deformation of flexible structure. Written in FORTRAN 77.

  17. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Stay Up to Date with ACS Association Management Jobs Events Find a Surgeon Patients and Family Contact My Profile Shop ( 0 ) Cart Donate American College of Surgeons Education Patients and Family Skills Programs Ostomy Home Skills Program Ostomy Home Skills ...

  18. Logic Programming: PROLOG.

    Science.gov (United States)

    Lopez, Antonio M., Jr.

    1989-01-01

    Provides background material on logic programing and presents PROLOG as a high-level artificial intelligence programing language that borrows its basic constructs from logic. Suggests the language is one which will help the educator to achieve various goals, particularly the promotion of problem solving ability. (MVL)

  19. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... checklist Evaluation (Complete the Ostomy Patient Survey . We need your opinion!) Program outcomes The ACS Ostomy Home Skills Kit program covers: Adult Ostomy Pediatric Ostomy Ostomía Adulto Order Today Ostomy Home Skills Kit (login or create account ...

  20. Monadic Functional Reactive Programming

    NARCIS (Netherlands)

    A.J. van der Ploeg (Atze); C Shan

    2013-01-01

    htmlabstractFunctional Reactive Programming (FRP) is a way to program reactive systems in functional style, eliminating many of the problems that arise from imperative techniques. In this paper, we present an alternative FRP formulation that is based on the notion of a reactive computation: a

  1. Waco Head Start Program.

    Science.gov (United States)

    Porter, Para

    The Economic Opportunity Act of 1964 led to the formation of three separate Head Start Programs in Waco, Texas. The first year, 1,500 children were involved. Of these, 40 percent were Negro, 30 percent Latin American, and 30 percent white. All teachers received a week of preparatory study at the University of Texas. The program involved four areas…

  2. INEL BNCT Program

    Energy Technology Data Exchange (ETDEWEB)

    Ackermann, A.L. (ed.)

    1991-08-01

    This Bulletin presents a summary of accomplishments and highlights in the Idaho National Engineering Laboratory's (INEL) Boron Neutron Capture Therapy (BNCT) Program for August 1991. This bulletin includes information on the brain tumor and melanoma research programs, Power Burst Facility (PBF) technical support and modifications, PBF operations, and updates to the animal data charts.

  3. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... BleedingControl.org Trauma Quality Programs National Trauma Data Bank Trauma Quality Improvement Program Mentoring for Excellence in ... Future Clinical Congresses MyCME About MyCME About MyCME Claim and Manage Your CME CME Live Educational Activities ...

  4. Programmed cell death

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-12-31

    The purpose of this conference to provide a multidisciplinary forum for exchange of state-of-the-art information on the role programmed cell death plays in normal development and homeostasis of many organisms. This volume contains abstracts of papers in the following areas: invertebrate development; immunology/neurology; bcl-2 family; biochemistry; programmed cell death in viruses; oncogenesis; vertebrate development; and diseases.

  5. Responsive Space Program Brief

    Energy Technology Data Exchange (ETDEWEB)

    Dors, Eric E. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2014-03-11

    The goal of the Responsive Space program is to make significant, integrated science and technology contributions to the end-to-end missions of the U.S. Government that protect against global emerging and nuclear threats, from the earliest adversary planning through resilient event response report describes the LANL space program, mission, and other activities. The report describes some of their activities.

  6. NORD's Patient Assistance Programs

    Science.gov (United States)

    ... 203-486-8462 *learn more about this program* *aprender más sobre este programa* Chronic Non-Infectious Uveitis | ... 203-486-8033 *learn more about this program* *aprender más sobre este programa* Cystinuria | Accepting Applications Co- ...

  7. Environmental Horticulture Program Guide.

    Science.gov (United States)

    Georgia Univ., Athens. Dept. of Vocational Education.

    This program guide contains the standard environmental horticulture curriculum for technical institutes in Georgia. The curriculum encompasses the minimum competencies required for entry-level workers in the environmental horticulture field. The general information section contains the following: purpose and objectives; program description,…

  8. Programming Language Paradigms

    Directory of Open Access Journals (Sweden)

    Bartoníček Jan

    2014-01-01

    Full Text Available This paper's goal is to briefly explain the basic theory behind programming languages and their history while taking a close look at different programming paradigms that are used today as well as describing their differences, benefits, and drawbacks

  9. Programs and Expertise

    CERN Document Server

    2001-01-01

    Description of programs and expertise implemented by Radiation Protection Centre is presented. RPC implements study assessing the doses received by air crew members of Lithuanian Airlines. In 2001 RPC started measurements of indoor radon concentrations in the houses of regions with karst formations, commenced new program analyzing amounts of radionuclides in typical diet of hospital patients.

  10. Introduction - regional monitoring programs

    Science.gov (United States)

    Richard L. Hutto; C. John Ralph

    2005-01-01

    There is increasing interest in the initiation of regional or statewide monitoring programs that are less extensive than national efforts such as the Breeding Bird Survey. A number of regional programs have been in existence for a decade or more, so the papers in this section represented an effort to bring together the collective experience of the people who had...

  11. The Greenfoot Programming Environment

    Science.gov (United States)

    Kolling, Michael

    2010-01-01

    Greenfoot is an educational integrated development environment aimed at learning and teaching programming. It is aimed at a target audience of students from about 14 years old upwards, and is also suitable for college- and university-level education. Greenfoot combines graphical, interactive output with programming in Java, a standard, text-based…

  12. Functional Programming Using F#

    DEFF Research Database (Denmark)

    Hansen, Michael Reichhardt; Rischel, Hans

    This comprehensive introduction to the principles of functional programming using F# shows how to apply basic theoretical concepts to produce succinct and elegant programs. It demonstrates the role of functional programming in a wide spectrum of applications including databases and systems....... Coverage also includes advanced features in the .NET library, the imperative features of F# and topics such as text processing, sequences, computation expressions and asynchronous computation. With a broad spectrum of examples and exercises, the book is perfect for courses in functional programming...... and for self-study. Enhancing its use as a text is an accompanying website with downloadable programs, lecture slides, a mini-projects and links to further F# sources....

  13. Database Programming Languages

    DEFF Research Database (Denmark)

    This volume contains the proceedings of the 11th International Symposium on Database Programming Languages (DBPL 2007), held in Vienna, Austria, on September 23-24, 2007. DBPL 2007 was one of 15 meetings co-located with VLBD (the International Conference on Very Large Data Bases). DBPL continues...... to present the very best work at the intersection of dataase and programming language research. The proceedings include a paper based on the invited talk by Wenfie Fan and the 16 contributed papers that were selected by at least three members of the program committee. In addition, the program commitee sought...... the opinions of additional referees selected becauce of their expertise on particular topics. The final selection of papers was made during last week of July. We would like to thank all of the aurhors who submitted papers to the conference, and the members of the program committee  for their excellent work...

  14. Laptop programs for students.

    Science.gov (United States)

    Zucker, Andrew A; Light, Daniel

    2009-01-02

    With the continuing decline in costs of technology, programs are proliferating worldwide to put networked laptop computers into the hands of millions of students on a routine basis. The reasons policy-makers support these programs are based on economic arguments, equity concerns, and widespread interest in education reform. Studies of laptop programs in schools report that they increase students' engagement in school, improve technology skills, and have positive effects on students' writing. However, evidence of the effectiveness of large-scale laptop programs in other learning domains is scarce. Research in many nations suggests that laptop programs will be most successful as part of balanced, comprehensive initiatives that address changes in education goals, curricula, teacher training, and assessment.

  15. Crisis intervention: program evaluation.

    Science.gov (United States)

    Simington, J A; Cargill, L; Hill, W

    1996-11-01

    Crisis intervention is based upon crisis theory and is defined as a short-term active mode of therapy that focuses on solving the client's immediate problem and reestablishing psychological equilibrium. The crisis intervention program was the first phase in the development of a broader mental health program with advancement decisions being based upon evaluation results of this initial phase. An evaluation methodology using the Stufflebeam Goal-Stakeholder Model (1980) was designed and implemented. A satisfaction survey was conducted to develop a database relative to the program's process. The Mental Health Category Measure, and the Crisis Call Outcome Rating Scale were used to capture outcome data. Analysis of the qualitative and quantitative data indicate that stakeholders are satisfied with the program. outcome data demonstrates that the program produces the intended outcomes. Triangulation, a method of comparing the qualitative and quantitative findings revealed consistency, and thus provides confidence in the accuracy of the findings.

  16. Scientific Programming in Fortran

    Directory of Open Access Journals (Sweden)

    W. Van Snyder

    2007-01-01

    Full Text Available The Fortran programming language was designed by John Backus and his colleagues at IBM to reduce the cost of programming scientific applications. IBM delivered the first compiler for its model 704 in 1957. IBM's competitors soon offered incompatible versions. ANSI (ASA at the time developed a standard, largely based on IBM's Fortran IV in 1966. Revisions of the standard were produced in 1977, 1990, 1995 and 2003. Development of a revision, scheduled for 2008, is under way. Unlike most other programming languages, Fortran is periodically revised to keep pace with developments in language and processor design, while revisions largely preserve compatibility with previous versions. Throughout, the focus on scientific programming, and especially on efficient generated programs, has been maintained.

  17. Program summaries for 1979: energy sciences programs

    Energy Technology Data Exchange (ETDEWEB)

    1979-12-01

    This report describes the objectives of the various research programs being conducted by the Chemical Sciences, Metallurgy and Materials Science, and Process Science divisions of the BNL Dept. of Energy and Environment. Some of the more significant accomplishments during 1979 are also reported along with plans for 1980. Some of the topics under study include porphyrins, combustion, coal utilization, superconductors, semiconductors, coal, conversion, fluidized-bed combustion, polymers, etc. (DLC)

  18. Programming by Numbers -- A Programming Method for Complete Novices

    NARCIS (Netherlands)

    Glaser, Hugh; Hartel, Pieter H.

    2000-01-01

    Students often have difficulty with the minutiae of program construction. We introduce the idea of `Programming by Numbers', which breaks some of the programming process down into smaller steps, giving such students a way into the process of Programming in the Small. Programming by Numbers does not

  19. 40 CFR 68.170 - Prevention program/Program 2.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 15 2010-07-01 2010-07-01 false Prevention program/Program 2. 68.170 Section 68.170 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CHEMICAL ACCIDENT PREVENTION PROVISIONS Risk Management Plan § 68.170 Prevention program/Program...

  20. 75 FR 15484 - Railroad Safety Technology Program Grant Program

    Science.gov (United States)

    2010-03-29

    ... Federal Railroad Administration Railroad Safety Technology Program Grant Program AGENCY: Federal Railroad... Applications. SUMMARY: The Rail Safety Technology Program is a newly authorized program under the Rail Safety Improvement Act of 2008 (RSIA) (Pub. L. 110-432; October 16, 2008). The program authorizes the Department of...

  1. 40 CFR 68.175 - Prevention program/Program 3.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 15 2010-07-01 2010-07-01 false Prevention program/Program 3. 68.175 Section 68.175 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) CHEMICAL ACCIDENT PREVENTION PROVISIONS Risk Management Plan § 68.175 Prevention program/Program...

  2. A Program Transformation for Backwards Analysis of Logic Programs

    DEFF Research Database (Denmark)

    Gallagher, John Patrick

    2003-01-01

    programs presented here is based on a transformation of the input program, which makes explicit the dependencies of the given program points on the initial goals. The transformation is derived from the resultants semantics of logic programs. The transformed program is then analysed using a standard...... framework and no special properties of the abstract domain....

  3. Catalysis and biocatalysis program

    Science.gov (United States)

    Ingham, J. D.

    1993-01-01

    This final report presents a summary of research activities and accomplishments for the Catalysis and Biocatalysis Program, which was renamed the Biological and Chemical Technologies Research (BCTR) Program, currently of the Advanced Industrial Concepts Division (AICD), Office of Industrial Technologies of the Department of Energy (DOE). The Program was formerly under the Division of Energy Conversion and Utilization Technologies (ECUT) until the DOE reorganization in April, 1990. The goals of the BCTR Program are consistent with the initial ECUT goals, but represent an increased effort toward advances in chemical and biological technology transfer. In addition, the transition reflects a need for the BCTR Program to assume a greater R&D role in chemical catalysis as well as a need to position itself for a more encompassing involvement in a broader range of biological and chemical technology research. The mission of the AICD is to create a balanced Program of high risk, long-term, directed interdisciplinary research and development that will improve energy efficiency and enhance fuel flexibility in the industrial sector. Under AICD, the DOE Catalysis and Biocatalysis Program sponsors research and development in furthering industrial biotechnology applications and promotes the integrated participation of universities, industrial companies, and government research laboratories.

  4. Final report ASTC Program

    Energy Technology Data Exchange (ETDEWEB)

    Smithson, T.

    1996-03-15

    The specific goals of the ASTC program were: to pilot and administer a year round program to engage and support ethnic minority and women students to enter the pre-college teaching profession; and to develop the ASTC program across California on all twenty CSU campuses. The initial goal of piloting a year round program to engage and support ethnic or underrepresented science students to enter the teaching profession was put in place at CSUS in the Fall of 1993, with the recruitment of students to enter the program in the Spring of 1993. Three students were selected to enter the program, one male Latino, one female Latina and one Caucasian female. The areas of study of these students was respectively biology, physics and geology. All of the students were within two years or less of completing their degree requirements. During the first semester of the program the authors worked on the portion of the model dealing with student participation in the schools with a mentor teacher. The idea being the students would spend a minimum of six hours a week in the classroom of the mentor teacher working with them and their students. In addition the students were assigned to a faculty mentor within their discipline, a person whom they could go to for help and support in their academic efforts. The report discusses what was learned.

  5. Extreme Programming: Maestro Style

    Science.gov (United States)

    Norris, Jeffrey; Fox, Jason; Rabe, Kenneth; Shu, I-Hsiang; Powell, Mark

    2009-01-01

    "Extreme Programming: Maestro Style" is the name of a computer programming methodology that has evolved as a custom version of a methodology, called extreme programming that has been practiced in the software industry since the late 1990s. The name of this version reflects its origin in the work of the Maestro team at NASA's Jet Propulsion Laboratory that develops software for Mars exploration missions. Extreme programming is oriented toward agile development of software resting on values of simplicity, communication, testing, and aggressiveness. Extreme programming involves use of methods of rapidly building and disseminating institutional knowledge among members of a computer-programming team to give all the members a shared view that matches the view of the customers for whom the software system is to be developed. Extreme programming includes frequent planning by programmers in collaboration with customers, continually examining and rewriting code in striving for the simplest workable software designs, a system metaphor (basically, an abstraction of the system that provides easy-to-remember software-naming conventions and insight into the architecture of the system), programmers working in pairs, adherence to a set of coding standards, collaboration of customers and programmers, frequent verbal communication, frequent releases of software in small increments of development, repeated testing of the developmental software by both programmers and customers, and continuous interaction between the team and the customers. The environment in which the Maestro team works requires the team to quickly adapt to changing needs of its customers. In addition, the team cannot afford to accept unnecessary development risk. Extreme programming enables the Maestro team to remain agile and provide high-quality software and service to its customers. However, several factors in the Maestro environment have made it necessary to modify some of the conventional extreme-programming

  6. NREL biofuels program overview

    Energy Technology Data Exchange (ETDEWEB)

    Mielenz, J.R. [National Renewable Energy Laboratory, Golden, CO (United States)

    1996-09-01

    The NREL Biofuels Program has been developing technology for conversion of biomass to transportation fuels with support from DOE Office of Transportation Technologies Biofuels System Program. This support has gone to both the National Renewable Energy Laboratory, and over 100 subcontractors in universities and industry. This overview will outline the value of the Biofuels development program to the Nation, the current status of the technology development, and what research areas still need further support and progress for the development of a biofuels industry in the US.

  7. Declarative programming in PROLOG

    Directory of Open Access Journals (Sweden)

    Felician ALECU

    2014-03-01

    Full Text Available The declarative programming by declarative languages is clearly the best option a programmer can have for a completely readable, flexible and extensible code. Today, the economics of programming is clearly focused on the declarative paradigm while most imperative languages are trying to become cost effective by using new added declarative features for productivity and ease of use, like the Java 8. This paper tries to demonstrate a declarative language like PROLOG is perfectly suitable to be used to solve even common programming issue, like deciding an element is part of an array or not.

  8. Secure Dynamic Program Repartitioning

    DEFF Research Database (Denmark)

    Hansen, Rene Rydhoff; Probst, Christian

    2005-01-01

    Secure program partitioning has been introduced as a language-based technique to allow the distribution of data and computation across mutualy untrusted hosts, while at the same time guaranteeing the protection of confidential data. Programs that have been annotated with security types...... are automaticaly partitioned by the compiler. The main drawback in this setting is that both the trust hierarchy and the set of hosts are fixed once the program has been partitioned. This paper suggests an enhanced version of the partitioning framework, where the trust relation stil remains fixed...

  9. Database principles programming performance

    CERN Document Server

    O'Neil, Patrick

    2014-01-01

    Database: Principles Programming Performance provides an introduction to the fundamental principles of database systems. This book focuses on database programming and the relationships between principles, programming, and performance.Organized into 10 chapters, this book begins with an overview of database design principles and presents a comprehensive introduction to the concepts used by a DBA. This text then provides grounding in many abstract concepts of the relational model. Other chapters introduce SQL, describing its capabilities and covering the statements and functions of the programmi

  10. Practical C++ Programming

    CERN Document Server

    Oualline, Steve

    2003-01-01

    C++ is a powerful, highly flexible, and adaptable programming language that allows software engineers to organize and process information quickly and effectively. But this high-level language is relatively difficult to master, even if you already know the C programming language. The 2nd edition of Practical C++ Programming is a complete introduction to the C++ language for programmers who are learning C++. Reflecting the latest changes to the C++ standard, this 2nd edition takes a useful down-to-earth approach, placing a strong emphasis on how to design clean, elegant code. In short, to-th

  11. Beginning Swift programming

    CERN Document Server

    Lee, Wei-Meng

    2014-01-01

    Enter the Swift future of iOS and OS X programming Beginning Swift Programming is your ideal starting point for creating Mac, iPhone, and iPad apps using Apple's new Swift programming language. Written by an experienced Apple developer and trainer, this comprehensive guide explains everything you need to know to jumpstart the creation of your app idea. Coverage includes data types, strings and characters, operators and functions, arrays and dictionaries, control flow, and looping, with expert guidance on classes, objects, class inheritance, closures, protocols, and generics. This succinct - ye

  12. Modeling EERE Deployment Programs

    Energy Technology Data Exchange (ETDEWEB)

    Cort, Katherine A.; Hostick, Donna J.; Belzer, David B.; Livingston, Olga V.

    2007-11-08

    The purpose of this report is to compile information and conclusions gathered as part of three separate tasks undertaken as part of the overall project, “Modeling EERE Deployment Programs,” sponsored by the Planning, Analysis, and Evaluation office within the Department of Energy’s Office of Energy Efficiency and Renewable Energy (EERE). The purpose of the project was to identify and characterize the modeling of deployment programs within the EERE Technology Development (TD) programs, address improvements to modeling in the near term, and note gaps in knowledge where future research is needed.

  13. New atmospheric program

    Science.gov (United States)

    The National Science Foundation's Division of Atmospheric Sciences has established an Upper Atmospheric Facilities program within its Centers and Facilities section. The program will support the operation of and the scientific research that uses the longitudinal chain of incoherent scatter radars. The program also will ensure that the chain is maintained as a state-of-the-art research tool available to all interested and qualified scientists.For additional information, contact Richard A. Behnke, Division of Atmospheric Sciences, National Science Foundation, 1800 G Street, N.W., Washington, DC 20550 (telephone: 202-357-7390).

  14. Automatic Program Development

    DEFF Research Database (Denmark)

    Automatic Program Development is a tribute to Robert Paige (1947-1999), our accomplished and respected colleague, and moreover our good friend, whose untimely passing was a loss to our academic and research community. We have collected the revised, updated versions of the papers published in his...... by members of the IFIP Working Group 2.1 of which Bob was an active member. All papers are related to some of the research interests of Bob and, in particular, to the transformational development of programs and their algorithmic derivation from formal specifications. Automatic Program Development offers...

  15. Cumulative Poisson Distribution Program

    Science.gov (United States)

    Bowerman, Paul N.; Scheuer, Ernest M.; Nolty, Robert

    1990-01-01

    Overflow and underflow in sums prevented. Cumulative Poisson Distribution Program, CUMPOIS, one of two computer programs that make calculations involving cumulative Poisson distributions. Both programs, CUMPOIS (NPO-17714) and NEWTPOIS (NPO-17715), used independently of one another. CUMPOIS determines cumulative Poisson distribution, used to evaluate cumulative distribution function (cdf) for gamma distributions with integer shape parameters and cdf for X (sup2) distributions with even degrees of freedom. Used by statisticians and others concerned with probabilities of independent events occurring over specific units of time, area, or volume. Written in C.

  16. Designing computer programs

    CERN Document Server

    Haigh, Jim

    1994-01-01

    This is a book for students at every level who are learning to program for the first time - and for the considerable number who learned how to program but were never taught to structure their programs. The author presents a simple set of guidelines that show the programmer how to design in a manageable structure from the outset. The method is suitable for most languages, and is based on the widely used 'JSP' method, to which the student may easily progress if it is needed at a later stage.Most language specific texts contain very little if any information on design, whilst books on des

  17. Procedure and Program Examples

    Science.gov (United States)

    Britz, Dieter

    Here some modules, procedures and whole programs are described, that may be useful to the reader, as they have been, to the author. They are all in Fortran 90/95 and start with a generally useful module, that will be used in most procedures and programs in the examples, and another module useful for programs using a Rosenbrock variant. The source texts (except for the two modules) are not reproduced here, but can be downloaded from the web site www.springerlink.com/openurl.asp?genre=issue &issn=1616-6361&volume=666 (the two lines form one contiguous URL!).

  18. Assembly processor program converts symbolic programming language to machine language

    Science.gov (United States)

    Pelto, E. V.

    1967-01-01

    Assembly processor program converts symbolic programming language to machine language. This program translates symbolic codes into computer understandable instructions, assigns locations in storage for successive instructions, and computer locations from symbolic addresses.

  19. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Safety Conference ACS Clinical Scholars in Residence Clinical Trials Methods Course Health Services Research Methods Course Surgeon ... Institute Featured Articles Nora Institute Mission The FIRST Trial Advocacy Advocacy Overview Quality Payment Program QPP Resource ...

  20. Logic Programming for Linguistics

    DEFF Research Database (Denmark)

    Christiansen, Henning

    2010-01-01

    This article gives a short introduction on how to get started with logic pro- gramming in Prolog that does not require any previous programming expe- rience. The presentation is aimed at students of linguistics, but it does not go deeper into linguistics than any student who has some ideas of what...... a computer is, can follow the text. I cannot, of course, cover all aspects of logic programming in this text, and so we give references to other sources with more details. Students of linguistics must have a very good motivation to spend time on programming, and I show here how logic programming can be used...... for modelling different linguistic phenomena. When modelling language in this way, as opposed to using only paper and pencil, your models go live: you can run and test your models and you can use them as automatic language analyzers. This way you will get a better understanding of the dynamics of languages...

  1. Wetland Program Pilot Grants

    Data.gov (United States)

    U.S. Environmental Protection Agency — The Wetland Grant Database (WGD) houses grant data for Wetland Program Development Grants (created by EPA in 1990 under the Clean Water Act Section 104(b)(3)...

  2. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Education Cancer Education Cancer Programs Conference: Creating a Culture of Quality CoC Events Quality Education Quality Education ... Matters NIH-ACS Symposium Symposium Findings Search Relevant Publications Optimal Access Resources Members Contact Us Publications ACS ...

  3. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... supports the entire surgical team with quality, comprehensive education. The standardized interactive program has been developed by the American College of Surgeons (ACS) in collaboration with the American Society of Colon and Rectal Surgeons (ASCRS), American Urological ...

  4. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Quality ACS Leadership in Quality Setting the Quality Standard Optimal Resources for Surgical Quality and Safety Inspiring ... Bariatric Surgery Accreditation and Quality Improvement Program About Standards Apply Participant Use Data File (PUF) Resources & FAQs ...

  5. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Complete the Ostomy Patient Survey . We need your opinion!) Program outcomes The ACS Ostomy Home Skills Kit ... ACS Links About ACS ACS Foundation Have a Question? Press Releases Shop My Profile American College of ...

  6. Agile Web Pilot Program

    National Research Council Canada - National Science Library

    Lang, Mark

    1997-01-01

    ... in an increasingly competitive global marketplace. The pilot program allowed 18 small and medium sized enterprises to experiment with new agile business practices in competitive manufacturing environments by forming virtual organizations within...

  7. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... I Want to Be a RAS-ACS Leader International Exchange Scholar Program Resources ... Contact Us Military Health System Strategic Partnership Military Health System Strategic Partnership Military ...

  8. Programming in Action

    Science.gov (United States)

    Alison, Graham

    1971-01-01

    Reviews a conference which covered programming through: (a) work-card and assignment systems (b) slide/tape systems (c) feed back systems and their applications in the fields of primary, secondary, and tertiary and further education." (Author/AA)

  9. Developmental programming of happiness.

    Science.gov (United States)

    Schmidt, Louis A; Fortier, Paz; Lahat, Ayelet; Tang, Alva; Mathewson, Karen J; Saigal, Saroj; Boyle, Michael H; Van Lieshout, Ryan J

    2017-09-01

    Being born at an extremely low birth weight (ELBW; programming hypotheses. Interfacing prenatal programming and differential susceptibility hypotheses, we tested whether individuals with ELBW in different childhood rearing environments showed different attention biases to positive and negative facial emotions in adulthood. Using the oldest known, prospectively followed cohort of ELBW survivors, we found that relative to normal birth weight controls (NBW; >2,500 grams), ELBW survivors displayed the highest and lowest attention bias to happy faces at age 30-35, depending on whether their total family income at age 8 was relatively low (environmental match) or high (environmental mismatch), respectively. This bias to happy faces was associated with a reduced likelihood of emotional problems. Findings suggest that differential susceptibility to positive emotions may be prenatally programmed, with effects lasting into adulthood. We discuss implications for integrating prenatal programming and differential susceptibility hypotheses, and the developmental origins of postnatal plasticity and resilience. © 2017 Wiley Periodicals, Inc.

  10. Amendment 80 Permit Program

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Amendment 80 Program was adopted by the North Pacific Fishery Management Council (Council) in June 2006. The final rule implementing Amendment 80 published in...

  11. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Resources Online Guide to Choosing a Surgical Residency Practice Management Workshops Patients and Family Patient Education Patient ... Educators ACS Fundamentals of Surgery Curriculum Transition to Practice Program ACS/APDS Surgery Resident Skills Curriculum ACS/ ...

  12. R high performance programming

    CERN Document Server

    Lim, Aloysius

    2015-01-01

    This book is for programmers and developers who want to improve the performance of their R programs by making them run faster with large data sets or who are trying to solve a pesky performance problem.

  13. CMS Program Statistics

    Data.gov (United States)

    U.S. Department of Health & Human Services — The CMS Office of Enterprise Data and Analytics has developed CMS Program Statistics, which includes detailed summary statistics on national health care, Medicare...

  14. Exploring Adaptive Program Behavior

    DEFF Research Database (Denmark)

    Bonnichsen, Lars Frydendal; Probst, Christian W.

    Modern computer systems are increasingly complex, with ever changing bottlenecks. This makes it difficult to ensure consistent performance when porting software, or even running it. Adaptivity, ie, switching between program variations, and dynamic recompilation have been suggested as solutions...

  15. Automatic Program Development

    DEFF Research Database (Denmark)

    Automatic Program Development is a tribute to Robert Paige (1947-1999), our accomplished and respected colleague, and moreover our good friend, whose untimely passing was a loss to our academic and research community. We have collected the revised, updated versions of the papers published in his...... honor in the Higher-Order and Symbolic Computation Journal in the years 2003 and 2005. Among them there are two papers by Bob: (i) a retrospective view of his research lines, and (ii) a proposal for future studies in the area of the automatic program derivation. The book also includes some papers...... by members of the IFIP Working Group 2.1 of which Bob was an active member. All papers are related to some of the research interests of Bob and, in particular, to the transformational development of programs and their algorithmic derivation from formal specifications. Automatic Program Development offers...

  16. Bridge resource program.

    Science.gov (United States)

    2013-09-01

    The mission of Rutgers Universitys Center for Advanced Infrastructure and Transportation (CAIT) Bridge Resource Program (BRP) is to provide bridge engineering support to the New Jersey Department of Transportation (NJDOT)s Bridge Engineering an...

  17. Unstable slope management program.

    Science.gov (United States)

    2009-08-01

    This Rapid Response Project gathered information on existing unstable slope management programs, with a : focus on asset management practices in the United States and overseas. On the basis of this study, the research : team summarized and recommende...

  18. Computer Program NIKE

    DEFF Research Database (Denmark)

    Spanget-Larsen, Jens

    2014-01-01

    FORTRAN source code for program NIKE (PC version of QCPE 343). Sample input and output for two model chemical reactions are appended: I. Three consecutive monomolecular reactions, II. A simple chain mechanism...

  19. The RERTR program.

    Energy Technology Data Exchange (ETDEWEB)

    Travelli, A.

    1997-11-14

    The Reduced Enrichment Research and Test Reactor (RERTR) Program was established in 1978 at the Argonne National Laboratory (ANL) by the Department of Energy (DOE), which continues to fund the program and to manage it in coordination with the Department of State (DOS), the Arms Control and Disarmament Agency (ACDA), and the Nuclear Regulatory Commission (NRC). The primary objective of the program is to develop the technology needed to use Low-Enrichment Uranium (LEU) instead of High-Enrichment Uranium (HEU) in research and test reactors, without significant penalties in experiment performance, economics, or safety. Eliminating the continuing need of HEU supplies for research and test reactors has long been an integral part of US nonproliferation policy. This paper reviews the main accomplishments of the program through the years.

  20. Geothermal Technologies Program: Utah

    Energy Technology Data Exchange (ETDEWEB)

    2005-06-01

    Geothermal Technologies Program Utah fact sheet describes the geothermal areas and use in Utah, focusing on power generation as well as direct use, including geothermally heated greenhouses, swimming pools, and therapeutic baths.

  1. A linear programming manual

    Science.gov (United States)

    Tuey, R. C.

    1972-01-01

    Computer solutions of linear programming problems are outlined. Information covers vector spaces, convex sets, and matrix algebra elements for solving simultaneous linear equations. Dual problems, reduced cost analysis, ranges, and error analysis are illustrated.

  2. Watchdog Audits Environmental Programs

    Science.gov (United States)

    Environmental Science and Technology, 1972

    1972-01-01

    Recent reorganization of the General Accounting Office is reviewed. With regard to environmental concerns it is aiming to see if federal environmental programs are meeting the congressionally mandated objectives of laws. Surveys and reviews are explained. (BL)

  3. Programming Pascal's Triangle

    Science.gov (United States)

    Curley, Walter

    1974-01-01

    After a brief discussion of Pascal's triangle and description of four methods of hand construction, the author provides FORTRAN and BASIC programs for computer construction based on recursive definition. (SD)

  4. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... in Trauma Surgery Advanced Trauma Life Support Verification, Review, and Consultation Program for Hospitals Trauma Systems Consultation ... to SRGS Issues Contact and FAQs ACS Case Reviews in Surgery ACS Case Reviews in Surgery ACS ...

  5. Pain Management Programs

    Science.gov (United States)

    ... mission The program is patient and family centered Work together for common, agreed upon goals Develop treatment plans based on individual needs Mutual respect and open communication as a team Frequent communication between primary provider and team members ...

  6. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Grant Program State Legislation Tracked by the College Maintenance of Certification Quality Quality Quality Electronic Health Records ( ... Liability Surgeons as Advocates Surgeons and Bundled Payment Models Surgeons as Institutional Employees Our Changing Health Care ...

  7. Education programs catalog

    Energy Technology Data Exchange (ETDEWEB)

    1994-05-01

    Since its formation in 1977, US DOE has been authorized to support education programs that help ensure an adequate supply of scientists, engineers, and technicians for energy-related research, production activities, and technology transfer. A national conference in 1989 produced a clear vision of the important role that DOE, its facilities, and its 169,000 Federal and contract employees can play in the educational life of their communities and the Nation. Many of the programs listed in this catalog are the result of this new vision; others have existed for many years. Purpose of this catalog is to make all DOE education efforts more widely known so that more teachers, students, and others can benefit. Supporting the hundreds of education programs (precollege, undergraduate, graduate, public) is the network of DOE national laboratories, technology centers, and other research facilities. Brief descriptions of each facility, its programs, and contact information for its education personnel are included.

  8. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Education Cancer Education Cancer Programs Conference: Creating a Culture of Quality CoC Events Quality Education Quality Education ... Ways to Give Meet Our Donors Major Gift Societies and Recognition Special Fundraising Initiatives News and Updates ...

  9. Ostomy Home Skills Program

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    Full Text Available ... Operation Giving Back Operation Giving Back About OGB Volunteer and Partner Portal Domestic Surgical Free Access Clinics ... Day Grant Program State Legislation Tracked by the College Maintenance of Certification Quality Quality Quality Electronic Health ...

  10. Epidemiology & Genomics Research Program

    Science.gov (United States)

    The Epidemiology and Genomics Research Program, in the National Cancer Institute's Division of Cancer Control and Population Sciences, funds research in human populations to understand the determinants of cancer occurrence and outcomes.

  11. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Membership Directory 2017 Annual Meeting 2016 Annual Meeting Women's Committee Mentorship Program Outside Activities ACS Archives Contact ... College Maintenance of Certification Quality Quality Quality ... State Legislative Action Center Leadership & Advocacy Summit ...

  12. Ostomy Home Skills Program

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    Full Text Available ... Systems Consultation Program Trauma Education Achieving Zero Preventable Deaths Conference Publications and Posters National Trauma System Injury ... Education Trauma Education Trauma Education Achieving Zero Preventable Deaths Trauma Systems Conference Advanced Surgical Skills for Exposure ...

  13. Human Reliability Program Workshop

    Energy Technology Data Exchange (ETDEWEB)

    Landers, John; Rogers, Erin; Gerke, Gretchen

    2014-05-18

    A Human Reliability Program (HRP) is designed to protect national security as well as worker and public safety by continuously evaluating the reliability of those who have access to sensitive materials, facilities, and programs. Some elements of a site HRP include systematic (1) supervisory reviews, (2) medical and psychological assessments, (3) management evaluations, (4) personnel security reviews, and (4) training of HRP staff and critical positions. Over the years of implementing an HRP, the Department of Energy (DOE) has faced various challenges and overcome obstacles. During this 4-day activity, participants will examine programs that mitigate threats to nuclear security and the insider threat to include HRP, Nuclear Security Culture (NSC) Enhancement, and Employee Assistance Programs. The focus will be to develop an understanding of the need for a systematic HRP and to discuss challenges and best practices associated with mitigating the insider threat.

  14. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Education Cancer Education Cancer Programs Conference: Creating a Culture of Quality CoC Events Quality Education Quality Education ... Benefits Current Openings Newsroom Newsroom Newsroom Press Releases Media Resources The FIRST Trial ACS Publications ACS in ...

  15. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... EHR Incentive Program Global Codes and Data Collection New Medicare Card Project Medicare Enrollment and Participation Medicare Inpatient & Outpatient Rules Physician Quality Reporting System (PQRS) Value-Based Payment Modifier Accountable Care Organizations ...

  16. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... EHR Incentive Program Global Codes and Data Collection New Medicare Card Project Medicare Enrollment and Participation Medicare ... Benefits Current Openings Newsroom Newsroom Newsroom Press Releases Media Resources The FIRST Trial ACS Publications ACS in ...

  17. Automotive fuel economy program

    Science.gov (United States)

    2002-09-01

    The Automotive Fuel Economy Program Annual Update summarizes the fuel economy performance of the vehicle fleet and the activities of the National Highway Traffic Safety Administration (NHTSA) during 2001. Included in this report is a section summariz...

  18. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... ACS NSQIP Now Participants Downloads NSQIP in the Literature Newsroom Contact Us Hospital Compare Quality and Safety ... Program Trauma Education Achieving Zero Preventable Deaths Conference Publications and Posters National Trauma System Injury Prevention and ...

  19. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Inpatient & Outpatient Rules Physician Quality Reporting System (PQRS) Value-Based Payment Modifier Accountable Care Organizations Regulatory Burden ... Records (EHR) Incentive Program Physician Quality Reporting System Value-Based Payment Modifier Quality and Resource Use Reports ...

  20. Knee Conditioning Program

    Science.gov (United States)

    ... daily activities and enjoy a more active, healthy lifestyle. Following a well-structured conditioning program will also help you return to sports and other recreational activities. This is a general ...

  1. Spine Conditioning Program

    Science.gov (United States)

    ... daily activities and enjoy a more active, healthy lifestyle. Following a well-structured conditioning program will also help you return to sports and other recreational activities. This is a general ...

  2. Hip Conditioning Program

    Science.gov (United States)

    ... daily activities and enjoy a more active, healthy lifestyle. Following a well-structured conditioning program will also help you return to sports and other recreational activities. This is a general ...

  3. Geothermal Technologies Program: Alaska

    Energy Technology Data Exchange (ETDEWEB)

    2005-02-01

    This fact sheets provides a summary of geothermal potential, issues, and current development in Alaska. This fact sheet was developed as part of DOE's GeoPowering the West initiative, part of the Geothermal Technologies Program.

  4. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... for Excellence in Trauma Surgery Advanced Trauma Life Support Verification, Review, and Consultation Program for Hospitals Trauma ... Skills for Exposure in Trauma Advanced Trauma Life Support Advanced Trauma Operative Management Basic Endovascular Skills for ...

  5. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... to Participate Resources Webinars for Young Surgeons YFA E-News Resident and Associate Society Resident and Associate ... ACS Leader International Exchange Scholar Program Resources RAS E-News Medical Students Operation Giving Back Operation Giving ...

  6. Natural Gas STAR Program

    Science.gov (United States)

    EPA’s Voluntary Methane Programs encourage oil and natural gas companies to adopt cost-effective technologies and practices that improve operational efficiency and reduce emissions of methane, a potent greenhouse gas.

  7. Diabetes Prevention Program (DPP)

    Science.gov (United States)

    ... Recruiting Patients & Families Consortia, Networks & Centers Reports & Planning Diabetes Prevention Program (DPP) Page Content On this page: ... increased risk of developing diabetes. [ Top ] Type 2 Diabetes and Prediabetes Type 2 diabetes is a disorder ...

  8. National Diabetes Education Program

    Science.gov (United States)

    ... Living Tips About WIN NIDDK Information Clearinghouses National Diabetes Education Program Together with more than 200 partners ... type 2 diabetes. Learn more about NDEP . National Diabetes Month You are the center of your diabetes ...

  9. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Education Patients Medical Professionals Skills Programs Find a Treatment Center Patient Safety Resources About the Patient Education ... Surgeons (ASCRS), American Urological Association (AUA), Certified Enterostomal Therapy Nurses (CETN), and the United Ostomy Associations of ...

  10. National Agriculture Imagery Program

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The National Agriculture Imagery Program (NAIP) acquires aerial imagery during the agricultural growing seasons in the continental U.S. A primary goal of the NAIP...

  11. Gillnet Tag Program

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Certain fishery management programs require vessels to obtain gillnet tags to be used with their gillnet gear. Gillnet tag data is a collection of requests and...

  12. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... CME Accreditation CME Joint Providership Program Verification of Knowledge and Skills Resources Educational Resources Educational Resources E- ... Disaster Management and Emergency Preparedness Rural Trauma Team Development Course Trauma Evaluation and Management Trauma CME Nora ...

  13. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Issues Stop Overregulating My OR EHR Incentive Program Global Codes and Data Collection New Medicare Card Project Medicare Enrollment and Participation Medicare Inpatient & Outpatient Rules Physician Quality Reporting System (PQRS) Value-Based Payment Modifier Accountable Care ...

  14. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Kits Broadcast Rights for Hospitals Ostomy Home Skills Hospital Quality Improvement Package The standardized interactive program has been developed by the ... and Associates Medical Students International Surgeons ...

  15. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Issues EHR Incentive Program Global Codes and Data Collection New Medicare Card Project Medicare Enrollment and Participation ... History History of the American College of Surgeons Collections Highlights Research 25- and 50- Year Fellows Recognition ...

  16. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... of Master Surgeon Educators ACS Fundamentals of Surgery Curriculum Transition to Practice Program ACS/APDS Surgery Resident Skills Curriculum ACS/APDS/ASE Resident Prep Curriculum ACS/ASE ...

  17. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... a Member Fellows International Fellows Associate Fellows Residents Medical Students Affiliate Members Fees and Dues Realize the ... US and Canada) International Fellows Associate Fellows Residents Medical Students Affiliate Members ACS Insurance Programs ACS Discount ...

  18. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Participate in Quality How to Participate in Advancing Care Information How to Participate in Improvement Activities How ... Program Federal Legislation Federal Legislation Federal Legislation Health Care Reform Summary Letters on Health Care Reform Medicare ...

  19. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... to Be a Surgeon Resident Resources Teaching Resources Online Guide to Choosing a Surgical Residency Practice Management Workshops Patients and Family Patient Education Patient Education Patients Medical Professionals Skills Programs Find ...

  20. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Mentoring for Excellence in Trauma Surgery Advanced Trauma Life Support Verification, Review, and Consultation Program for Hospitals ... Surgical Skills for Exposure in Trauma Advanced Trauma Life Support Advanced Trauma Operative Management Basic Endovascular Skills ...

  1. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Education Cancer Education Cancer Programs Conference: Creating a Culture of Quality CoC Events Quality Education Quality Education ... at ACS Careers at ACS About ACS Career Types Working at ACS ACS and Veterans Diversity at ...

  2. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Participate in Improvement Activities How to Participate in Cost Steps for Avoiding a Penalty Quality Payment Program ... Skills Kit supports patients with educational and simulation materials to learn and practice the skills needed for ...

  3. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... at ACS Careers at ACS About ACS Career Types Working at ACS ... Family Contact My Profile Shop ( 0 ) Cart Donate American College of Surgeons Education Patients and Family Skills Programs Ostomy Home Skills ...

  4. State Program Integrity Reviews

    Data.gov (United States)

    U.S. Department of Health & Human Services — State program integrity reviews play a critical role in how CMS provides effective support and assistance to states in their efforts to combat provider fraud and...

  5. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Advocacy Summit Webinars Practice Management Practice Management Practice Management CPT Coding Bulletin Articles CPT Coding Workshops ICD-10 Coding Physicians as Assistants at Surgery Webinars Primers and Compendiums Quality Payment Program AMA House of Delegates ACS in ...

  6. Learning Python network programming

    CERN Document Server

    Sarker, M O Faruque

    2015-01-01

    If you're a Python developer or a system administrator with Python experience and you're looking to take your first steps in network programming, then this book is for you. Basic knowledge of Python is assumed.

  7. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Participate Resources Webinars for Young Surgeons YFA E-News Resident and Associate Society Resident and Associate Society ... Leader International Exchange Scholar Program Resources RAS E-News Medical Students Operation Giving Back Operation Giving Back ...

  8. Joint Services Electronics Program.

    Science.gov (United States)

    1983-09-30

    Compound Semiconductors." 4 ......... I-*. Univesity of California. Berkeley Electronics Research Laboratory Joint Services Electronics Program August 15...reduction techniques [SCH-66,MCG- 73,HAM-75], for essentially i educing the proportionality constant. A significant portion of the probabilistic literature

  9. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Surgical Education Academy of Master Surgeon Educators ACS Fundamentals of Surgery Curriculum Transition to Practice Program ACS/ ... Workforce Trauma and EMS Cancer and Research ... Value-Based Payment Modifier Accountable Care Organizations ...

  10. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Education Cancer Education Cancer Programs Conference: Creating a Culture of Quality CoC Events Quality Education Quality Education Quality Education Quality and Safety Conference ACS Clinical Scholars in Residence Clinical Trials ...

  11. Community Involvement Training Program

    Science.gov (United States)

    A dynamic training conference that brings together more than 450 people from EPA and the Agency’s partners and stakeholders who plan and implement environmental community involvement, partnership, stewardship, outreach, and education programs.

  12. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... ASE Medical Student Core Curriculum ACS/ASE Medical Student Simulation-Based Surgical Skills Curriculum Cancer Education Cancer Education Cancer Education Cancer Programs Conference: Creating ...

  13. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... 2017 Clinical Congress 2017 About Clinical Congress CME Credit Media Information Educational Program Resources Clinical Congress App ... Optimal Access Matters NIH-ACS Symposium Symposium Findings Search Relevant Publications Optimal Access Resources Members Contact Us ...

  14. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Issues EHR Incentive Program Global Codes and Data Collection New Medicare Card Project Medicare Enrollment and Participation ... History History of the American College of Surgeons Collections Highlights Research 25- and 50-Year Fellows Recognition ...

  15. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Management Practice Management Practice Management CPT Coding Bulletin Articles CPT Coding Workshops ICD-10 Coding Physicians as Assistants at Surgery Webinars Primers and Compendiums Quality Payment Program AMA ...

  16. NPDES Stormwater Program

    Science.gov (United States)

    The National Pollutant Discharge Elimination System (NPDES) stormwater program regulates some stormwater discharges from three potential sources: municipal separate storm sewer systems (MS4s), construction activities, and industrial activities.

  17. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... YFA Mentor Programs YFA Speakers Bureau Top 10 Reasons to Participate Resources Webinars for Young Surgeons YFA ... Scholarships, Competitions, Awards, and Project Work Top 10 Reasons to Participate Grand Rounds Webinar Series RAS-JACS ...

  18. SBIR/STTR Programs

    Data.gov (United States)

    National Aeronautics and Space Administration — The NASA SBIR and STTR programs fund the research, development, and demonstration of innovative technologies that fulfill NASA needs as described in the annual...

  19. GPU-multicore programming

    OpenAIRE

    Dokken, Tor

    2007-01-01

    The evolution from single core CPUs to heterogeneous computing. Activities in SINTEF ICT related to heterogeneous computing within:Geometry processingLinear algebraPartial differential equationsVisualizationImage processing GPU-multicore programming

  20. Biodiesel Emissions Analysis Program

    Science.gov (United States)

    Using existing data, the EPA's biodiesel emissions analysis program sought to quantify the air pollution emission effects of biodiesel for diesel engines that have not been specifically modified to operate on biodiesel.

  1. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Cancer and Research Health Information Technology Scope of Practice Pediatric Issues Other Federal Legislative Issues Regulatory Issues Regulatory Issues Regulatory Issues EHR Incentive Program Global Codes and Data Collection New Medicare Card Project Medicare Enrollment and Participation ...

  2. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Grant Program State Legislation Tracked by the College Maintenance of Certification Quality Quality Quality Electronic Health Records ( ... Test Login SRGS Online Login Subscribe to SRGS Issues Contact and FAQs ACS Case Reviews in Surgery ...

  3. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... and Participation Medicare Inpatient & Outpatient Rules Physician Quality Reporting System (PQRS) Value-Based Payment Modifier Accountable Care ... Electronic Health Records (EHR) Incentive Program Physician Quality Reporting System Value-Based Payment Modifier Quality and Resource ...

  4. Java Programming Language

    Science.gov (United States)

    Shaykhian, Gholam Ali

    2007-01-01

    The Java seminar covers the fundamentals of Java programming language. No prior programming experience is required for participation in the seminar. The first part of the seminar covers introductory concepts in Java programming including data types (integer, character, ..), operators, functions and constants, casts, input, output, control flow, scope, conditional statements, and arrays. Furthermore, introduction to Object-Oriented programming in Java, relationships between classes, using packages, constructors, private data and methods, final instance fields, static fields and methods, and overloading are explained. The second part of the seminar covers extending classes, inheritance hierarchies, polymorphism, dynamic binding, abstract classes, protected access. The seminar conclude by introducing interfaces, properties of interfaces, interfaces and abstract classes, interfaces and cailbacks, basics of event handling, user interface components with swing, applet basics, converting applications to applets, the applet HTML tags and attributes, exceptions and debugging.

  5. Active Fire Mapping Program

    Science.gov (United States)

    Active Fire Mapping Program Current Large Incidents (Home) New Large Incidents Fire Detection Maps MODIS Satellite Imagery VIIRS Satellite Imagery Fire Detection GIS Data Fire Data in Google Earth ...

  6. Program Pemberdayaan Guru

    OpenAIRE

    Wardani, I G. A.K

    1999-01-01

    Although there are many aspects responsible for the quality of education, teachers are usually considered as the most responsible ones for the low students' achievement. To help the teachers perform professionally, an empowerment program for teachers should be conducted. Based on the analysis on some aspects related to teachers, an empowerment program consisting of two components is developed. The first component, competency empowerment, proposes six ideas, i.e. improve the student recruitmen...

  7. Program Pemberdayaan Guru

    OpenAIRE

    Wardani, I G. A.K

    2016-01-01

    Although there are many aspects responsible for the quality of education, teachers are usually considered as the most responsible ones for the low students' achievement. To help the teachers perform professionally, an empowerment program for teachers should be conducted. Based on the analysis on some aspects related to teachers, an empowerment program consisting of two components is developed. The first component, competency empowerment, proposes six ideas, i.e. improve the student recruitmen...

  8. Programming in Context

    DEFF Research Database (Denmark)

    Bennedsen, J.; Caspersen, M.E.

    2004-01-01

    The recommendations of the Joint Task Force on Computing Curricula 2001 encompass suggestions for an object-first introductory programming course. We have identified conceptual modeling as a lacking perspective in the suggestions for CS1. Conceptual modeling is the defining characteristic of object...... approach to programming; both of these are a big help to newcomers. The approach has a very positive impact on the number of students passing the course....

  9. Mammography accreditation program

    Energy Technology Data Exchange (ETDEWEB)

    Wilcox, P.

    1993-12-31

    In the mid-1980`s, the movement toward the use of dedicated mammography equipment provided significant improvement in breast cancer detection. However, several studies demonstrated that this change was not sufficient to ensure optimal image quality at a low radiation dose. In particular, the 1985 Nationwide Evaluation of X-ray Trends identified the wide variations in image quality and radiation dose, even from dedicated units. During this time period, the American Cancer Society (ACS) launched its Breast Cancer Awareness Screening Campaign. However, there were concerns about the ability of radiology to respond to the increased demand for optimal screening examinations that would result from the ACS program. To respond to these concerns, the ACS and the American College of Radiology (ACR) established a joint committee on mammography screening in 1986. After much discussion, it was decided to use the ACR Diagnostic Practice Accreditation Program as a model for the development of a mammography accreditation program. However, some constraints were required in order to make the program meet the needs of the ACS. This voluntary, peer review program had to be timely and cost effective. It was determined that the best way to address these needs would be to conduct the program by mail. Finally, by placing emphasis on the educational nature of the program, it would provide an even greater opportunity for improving mammographic quality. The result of this effort was that, almost six years ago, in May 1987, the pilot study for the ACR Mammography Accreditation Program (MAP) began, and in August of that year, the first applications were received. In November 1987, the first 3-year accreditation certificates were awarded.

  10. Concept medium program

    DEFF Research Database (Denmark)

    Bjerrum, Peter

    2003-01-01

    The present essays is an attempt to dertermine the architecural project of the 21st century in realation to a modern conception of space as the medium of architecture, and of society as its program. This attempt adopts the internal point of view of an architect in describing a modern architectural...... project within the framework: concept - program, these notions being concieved as spatial representations primarily and immediately "given" to architecture....

  11. Logic Programming in LISP.

    Science.gov (United States)

    1981-01-01

    Rapport, Groupe Intelligence Pasero, R., Artificielle , Universite d’Aix-Marseille, Roussel, P. Luminy, France, 1973. [Kowalski 1974] Kowalski, R. A...THIS PAGZ(Whan Doee Es tMord) Item 20 (Cont’d) ------ work in the area of artificial intelligence and those used in general program development into a...logic programming with LISP for implementing intelligent data base query systems. Continued developments will allow for enhancements to be made to the

  12. 2007 Biomass Program Overview

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2009-10-27

    The Biomass Program is actively working with public and private partners to meet production and technology needs. With the corn ethanol market growing steadily, researchers are unlocking the potential of non-food biomass sources, such as switchgrass and forest and agricultural residues. In this way, the Program is helping to ensure that cost-effective technologies will be ready to support production goals for advanced biofuels.

  13. Site environmental programs

    Energy Technology Data Exchange (ETDEWEB)

    Schmidt, J.W.; Hanf, R.W.

    1995-06-01

    This section of the 1994 Hanford Site Environmental Report summarizes the site environmental programs. Effluent monitoring and environmental surveillance programs monitor for impacts from operations in several areas. The first area consists of the point of possible release into the environment. The second area consists of possible contamination adjacent to DOE facilities, and the third area is the general environment both on and off the site.

  14. Learning Mathematics through Programming

    DEFF Research Database (Denmark)

    Misfeldt, Morten; Ejsing-Duun, Stine

    2015-01-01

    In this paper we explore the potentials for learning mathematics through programming by a combination of theoretically derived potentials and cases of practical pedagogical work. We propose a model with three interdependent learning potentials as programming which can: (1) help reframe the students...... to mathematics is paramount. Analyzing two cases, we suggest a number of ways in which didactical attention to epistemic mediation can support learning mathematics....

  15. Soft Concurrent Constraint Programming

    OpenAIRE

    Bistarelli, S.; Montanari, U.; Rossi, F.

    2002-01-01

    Soft constraints extend classical constraints to represent multiple consistency levels, and thus provide a way to express preferences, fuzziness, and uncertainty. While there are many soft constraint solving formalisms, even distributed ones, by now there seems to be no concurrent programming framework where soft constraints can be handled. In this paper we show how the classical concurrent constraint (cc) programming framework can work with soft constraints, and we also propose an extension ...

  16. Applications of Genetic Programming

    DEFF Research Database (Denmark)

    Gaunholt, Hans; Toma, Laura

    1996-01-01

    In this report a study of genetic programming (GP) has been performed with respect to a number of applications such as Symbolic function regression, Solving Symbolic Differential Equations, Image encoding, the ant problem etc.......In this report a study of genetic programming (GP) has been performed with respect to a number of applications such as Symbolic function regression, Solving Symbolic Differential Equations, Image encoding, the ant problem etc....

  17. Coastal Inlets Research Program

    Science.gov (United States)

    2015-10-30

    The Coastal Inlets Research Program (CIRP) is a R&D Program funded through the Operations & Maintenance (O&M) funding. The CIRP mission is to...transport, and vessel-induced flow and wake. In FY 2014, the Corps spent approximately $808 million in maintenance dredging of 152 million cubic...web-based tools and applications. The CIRP’s applied research and development provides quantitative and practical predictive tools and data to

  18. Declarative Programming in Java

    OpenAIRE

    Dina, Razvan; Felician ALECU

    2014-01-01

    Despite the code is rarely self-explanatory, the imperative programming languages are the most commonly used in our days by the programmers all over the world and Java is definitely the lead language in popularity. This paper tries to conclude if there are any chances to use the most popular programming language of the moment in a declarative manner, even if Java itself is an intrinsic imperative language.

  19. Declarative Programming in Java

    Directory of Open Access Journals (Sweden)

    Razvan DINA

    2014-03-01

    Full Text Available Despite the code is rarely self-explanatory, the imperative programming languages are the most commonly used in our days by the programmers all over the world and Java is definitely the lead language in popularity. This paper tries to conclude if there are any chances to use the most popular programming language of the moment in a declarative manner, even if Java itself is an intrinsic imperative language.

  20. President Ilvese kõne ETV otse-eetris / Toomas Hendrik Ilves

    Index Scriptorium Estoniae

    Ilves, Toomas Hendrik, 1953-

    2007-01-01

    President Toomas Hendrik Ilves esines 27. aprillil 2007 Eesti Televisioonis ja Eesti Raadios avaldusega seoses provokatsioonidega Tallinnas ööl vastu 27. aprilli 2007. a. Ilmunud ka: SL Õhtuleht 28. apr. 2007, lk. 12, pealk.: President Ilves: riik ei saa kõhelda; Eesti Päevaleht 28. apr. 2007, lk. 3, pealk.: Kurjategijad saavad karistada; Meie Maa 28. apr. 2007, lk. 3, pealk.: President kutsub üles näitama kainet ja kalkuleerivat mõistust; Narva Postiljon 28. apr. 2007, lk. 1, pealk.: President Ilves: Kutsun kõiki üles näitama kainet ja kalkuleerivat mõistust; Põhjarannik 28. apr. 2007, lk. 2, pealk.: President Ilves: "Kutsun kõiki üles näitama kainet ja kalkuleerivat mõistust"; Severnoje Poberezhje 28. apr. 2007, lk. 2; Virumaa Teataja 28. apr. 2007, lk. 11, pealk.: President Ilves: kutsun kõiki üles kainele mõistusele; Harjumaa 2. mai 2007, lk. 2, pealk.: Kutsun kõiki üles näitama kainet ja kalkuleerivat mõistust; Meie Kodu 9. mai 2007, lk. 1, pealk.: President Ilves: Kutsun kõiki üles näitama kainet ja kalkuleerivat mõistust