WorldWideScience

Sample records for program elements require

  1. Accounting of Multiplier Effect as a Required Element in Assessing the Effects of Social Programs

    Directory of Open Access Journals (Sweden)

    Yuliya Georgievna Lavrikova

    2015-12-01

    Full Text Available The article substantiates the importance of taking into account indirect effects of the programs, projects, activities (mainly social when deciding on the need to implement them. The problem of providing society with decent living conditions is studied. The article proves that in spite of some positive trends in the Russian construction market the issues of housing availability do not lose their significance. It notes that a variety of approaches to solving this problem have been developed, that is why it is critical to assess the effectiveness of each solution in order to choose the most suitable one. One of the tools for alleviating this problem – a program of housing construction savings – is discussed in detail; by means of the specially designed universal computational model we determine fiscal effectiveness of this program application in the Sverdlovsk Oblast. The analysis shows that the accounting of multiplier effect reveals the full range of possible effects of the program that can significantly affect the adoption of the decision to initiate actions necessary for their implementation

  2. Language delays, reading delays, and learning difficulties: interactive elements requiring multidimensional programming.

    Science.gov (United States)

    Hay, Ian; Elias, Gordon; Fielding-Barnsley, Ruth; Homel, Ross; Freiberg, Kate

    2007-01-01

    Researchers have hypothesized four levels of instructional dialogue and claimed that teachers can improve children's language development by incorporating these dialogue levels in their classrooms. It has also been hypothesized that enhancing children's early language development enhances children's later reading development. This quasi-experimental research study investigated both of these hypotheses using a collaborative service delivery model for Grade 1 children with language difficulties from a socially and economically disadvantaged urban community in Australia. Comparing the end-of-year reading achievement scores for the 57 children who received the language intervention with those of the 59 children in the comparison group, the findings from this research are supportive of both hypotheses. The interrelationships between learning difficulties, reading difficulties, and language difficulties are discussed along with children's development in vocabulary, use of memory strategies and verbal reasoning, and the need for multidimensional programming.

  3. Programming the finite element method

    CERN Document Server

    Smith, I M; Margetts, L

    2013-01-01

    Many students, engineers, scientists and researchers have benefited from the practical, programming-oriented style of the previous editions of Programming the Finite Element Method, learning how to develop computer programs to solve specific engineering problems using the finite element method. This new fifth edition offers timely revisions that include programs and subroutine libraries fully updated to Fortran 2003, which are freely available online, and provides updated material on advances in parallel computing, thermal stress analysis, plasticity return algorithms, convection boundary c

  4. Massively Parallel Finite Element Programming

    KAUST Repository

    Heister, Timo

    2010-01-01

    Today\\'s large finite element simulations require parallel algorithms to scale on clusters with thousands or tens of thousands of processor cores. We present data structures and algorithms to take advantage of the power of high performance computers in generic finite element codes. Existing generic finite element libraries often restrict the parallelization to parallel linear algebra routines. This is a limiting factor when solving on more than a few hundreds of cores. We describe routines for distributed storage of all major components coupled with efficient, scalable algorithms. We give an overview of our effort to enable the modern and generic finite element library deal.II to take advantage of the power of large clusters. In particular, we describe the construction of a distributed mesh and develop algorithms to fully parallelize the finite element calculation. Numerical results demonstrate good scalability. © 2010 Springer-Verlag.

  5. Time Elements May Require Change.

    Science.gov (United States)

    Clemons, Molly J.

    1993-01-01

    Argues that school districts may need to use a different time frame to accommodate the varied time requirements of the more flexible outcome-based education. Discusses three "alternate" scheduling methods currently in use and how they affect the teaching of journalism. (SR)

  6. 40 CFR 145.22 - Elements of a program submission.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 22 2010-07-01 2010-07-01 false Elements of a program submission. 145.22 Section 145.22 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS (CONTINUED) STATE UIC PROGRAM REQUIREMENTS State Program Submissions § 145.22 Elements of a...

  7. Global perspectives on trace element requirements.

    Science.gov (United States)

    Freeland-Graves, Jeanne H; Sanjeevi, Namrata; Lee, Jane J

    2015-01-01

    Trace elements are inorganic constituents of the human body present in concentrations less than 50mg/kg body weight. An exception is iron that is found in slightly higher amounts, 60 mg/kg body weight, but it is classified within this category due to its physiological roles. Requirements of trace elements can vary according to age, gender, growth, body composition, genetics, pregnancy, lactation, wound healing and burns, alcohol abuse, infections, and diseases (anemia, coronary artery, Keshan, Kashin-Beck). Additionally, interactions may occur with dietary factors, such as other minerals (iron versus copper), phytates (zinc), oxalates (iron), fiber (manganese), and polyphenolic compounds (molybdenum). On a global basis, requirements can vary according to soil and geographical location, food preparation and processing, food accessibility, cultural practices (geophagia) and pollution. Furthermore, global differences exist in body composition, ethnicity, and age of menarche. Published by Elsevier GmbH.

  8. Explicit Instruction Elements in Core Reading Programs

    OpenAIRE

    Child, Angela R.

    2012-01-01

    Classroom teachers are provided instructional recommendations for teaching reading from their adopted core reading programs (CRPs). Explicit instruction elements or what is also called instructional moves, including direct explanation, modeling, guided practice, independent practice, discussion, feedback, and monitoring, were examined within CRP reading lessons. This study sought to answer the question: What elements of explicit instruction or instructional moves are included in the five most...

  9. Writing analytic element programs in Python.

    Science.gov (United States)

    Bakker, Mark; Kelson, Victor A

    2009-01-01

    The analytic element method is a mesh-free approach for modeling ground water flow at both the local and the regional scale. With the advent of the Python object-oriented programming language, it has become relatively easy to write analytic element programs. In this article, an introduction is given of the basic principles of the analytic element method and of the Python programming language. A simple, yet flexible, object-oriented design is presented for analytic element codes using multiple inheritance. New types of analytic elements may be added without the need for any changes in the existing part of the code. The presented code may be used to model flow to wells (with either a specified discharge or drawdown) and streams (with a specified head). The code may be extended by any hydrogeologist with a healthy appetite for writing computer code to solve more complicated ground water flow problems. Copyright © 2009 The Author(s). Journal Compilation © 2009 National Ground Water Association.

  10. Explicit Instruction Elements in Core Reading Programs

    Science.gov (United States)

    Child, Angela R.

    2012-01-01

    Classroom teachers are provided instructional recommendations for teaching reading from their adopted core reading programs (CRPs). Explicit instruction elements or what is also called instructional moves, including direct explanation, modeling, guided practice, independent practice, discussion, feedback, and monitoring, were examined within CRP…

  11. Elements of an Employee Motivation Program

    Science.gov (United States)

    Ward, Ernest H.

    1974-01-01

    Ten elements which should be present in an employee motivation program are discussed in the context of achieving increased acceptance of organizational goals. They are: participation, performance measurement, knowledge of results, recognition; attitude measurement, communication, publicity, work assignment, work research, and supervisor motivation…

  12. Recycling of trace elements required for humans in CELSS

    Science.gov (United States)

    Ashida, A.

    1994-11-01

    Recycle of complete nourishment necessary for human should be constructed in CELSS (Controlled Ecological Life Support Systems). Essential elements necessary for human support are categorized as major elements, semi-major elements and trace elements. Recently, trace elements have been identified from considerations of local diseases, food additive problems, pollution problems and adult diseases, consisting of Fe, Zn, Cu, Se, Co, F, Si, Mn, Cr, I, As, Mo, Ni, V, Sn, Li, Br, Cd, Pb, B. A review of the biogeochemical history of the earth's biosphere and the physiological nature of humans and plants explains some of the requirements. A possible route for intake of trace elements is considered that trace elements are dissolved in some chemical form in water, absorbed by plants through their roots and then transfered to human as foods. There may be a posibility that living things absorb some trace elements from atmosphere. Management and recycling of trace elements in CELSS is discussed.

  13. Elements of programming interviews the insider's guide

    CERN Document Server

    Aziz, Adnan; Prakash, Amit

    2015-01-01

    This is a larger-format version of Elements of Programming Interviews. The language is C++. Specifically, the font size is larger, and the page size is 7"x10" (the regular format uses 6"x9"). The content is identical. Have you ever... Wanted to work at an exciting futuristic company? Struggled with an interview problem that could have been solved in 15 minutes? Wished you could study real-world computing problems? If so, you need to read Elements of Programming Interviews (EPI). EPI is your comprehensive guide to interviewing for software development roles. The core of EPI is a collection of over 250 problems with detailed solutions. The problems are representative of interview questions asked at leading software companies. The problems are illustrated with 200 figures, 300 tested programs, and 150 additional variants. The book begins with a summary of the nontechnical aspects of interviewing, such as strategies for a great interview, common mistakes, perspectives from the other side of the table,...

  14. Fundamental Elements of Transition Program Design

    Science.gov (United States)

    Karmelita, Courtney

    2017-01-01

    Adult learners require supports and services to help them successfully transition into taking on the demands and expectations of college students. Transition programs have grown in popularity as a means to aid adult learners as they transition to higher education. Unfortunately, previous research on adult learner participation in transition…

  15. Determining minimal display element requirements for surface map displays

    Science.gov (United States)

    2003-04-14

    There is a great deal of interest in developing electronic surface map displays to enhance safety and reduce incidents and incursions on or near the airport surface. There is a lack of research, however, detailing the minimal display elements require...

  16. Mixing Formal and Informal Model Elements for Tracing Requirements

    DEFF Research Database (Denmark)

    Jastram, Michael; Hallerstede, Stefan; Ladenberger, Lukas

    2011-01-01

    Tracing between informal requirements and formal models is challenging. A method for such tracing should permit to deal efficiently with changes to both the requirements and the model. A particular challenge is posed by the persisting interplay of formal and informal elements. In this paper, we...... a system for traceability with a state-based formal method that supports refinement. We do not require all specification elements to be modelled formally and support incremental incorporation of new specification elements into the formal model. Refinement is used to deal with larger amounts of requirements...... describe an incremental approach to requirements validation and systems modelling. Formal modelling facilitates a high degree of automation: it serves for validation and traceability. The foundation for our approach are requirements that are structured according to the WRSPM reference model. We provide...

  17. Space Radiation Program Element Tissue Sharing Forum

    Science.gov (United States)

    Wu, H.; Mayeaux, B M.; Huff, J. L.; Simonsen, L. C.

    2016-01-01

    Over the years, a large number of animal experiments have been conducted at the NASA Space Radiation Laboratory and other facilities under the support of the NASA Space Radiation Program Element (SRPE). Studies using rodents and other animal species to address the space radiation risks will remain a significant portion of the research portfolio of the Element. In order to maximize scientific return of the animal studies, the SRPE has recently released the Space Radiation Tissue Sharing Forum. The Forum provides access to an inventory of investigator-stored tissue samples and enables both NASA SRPE members and NASA-funded investigators to exchange information regarding stored and future radiobiological tissues available for sharing. Registered users may review online data of available tissues, inquire about tissues posted, or request tissues for an upcoming study using an online form. Investigators who have upcoming sacrifices are also encouraged to post the availability of samples using the discussion forum. A brief demo of the forum will be given during the presentation

  18. 49 CFR 452.9 - Elements of a continuous examination program.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 6 2010-10-01 2010-10-01 false Elements of a continuous examination program. 452.9 Section 452.9 Transportation Other Regulations Relating to Transportation (Continued) COAST GUARD... Elements of a continuous examination program. (a) Examinations required by § 452.7 must conform to the...

  19. A Type System for Required/Excluded Elements in CLS

    Directory of Open Access Journals (Sweden)

    Mariangiola Dezani-Ciancaglini

    2009-11-01

    Full Text Available The calculus of looping sequences is a formalism for describing the evolution of biological systems by means of term rewriting rules. We enrich this calculus with a type discipline to guarantee the soundness of reduction rules with respect to some biological properties deriving from the requirement of certain elements, and the repellency of others. As an example, we model a toy system where the repellency of a certain element is captured by our type system and forbids another element to exit a compartment.

  20. 40 CFR 271.5 - Elements of a program submission.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Elements of a program submission. 271.5 Section 271.5 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... Authorization § 271.5 Elements of a program submission. (a) Any State that seeks to administer a program under...

  1. 7 CFR 18.4 - Elements of program.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Elements of program. 18.4 Section 18.4 Agriculture Office of the Secretary of Agriculture EQUAL EMPLOYMENT OPPORTUNITY IN THE STATE COOPERATIVE EXTENSION SERVICES § 18.4 Elements of program. A satisfactory program shall include: (a) A statement of policy...

  2. NASA'S Water Resources Element Within the Applied Sciences Program

    Science.gov (United States)

    Toll, David; Doorn, Bradley; Engman, Edwin

    2010-01-01

    The NASA Applied Sciences Program works within NASA Earth sciences to leverage investment of satellite and information systems to increase the benefits to society through the widest practical use of NASA research results. Such observations provide a huge volume of valuable data in both near-real-time and extended back nearly 50 years about the Earth's land surface conditions such as land cover type, vegetation type and health, precipitation, snow, soil moisture, and water levels and radiation. Observations of this type combined with models and analysis enable satellite-based assessment of numerous water resources management activities. The primary goal of the Earth Science Applied Science Program is to improve future and current operational systems by infusing them with scientific knowledge of the Earth system gained through space-based observation, model results, and development and deployment of enabling technologies, systems, and capabilities. Water resources is one of eight elements in the Applied Sciences Program and it addresses concerns and decision making related to water quantity and water quality. With increasing population pressure and water usage coupled with climate variability and change, water issues are being reported by numerous groups as the most critical environmental problems facing us in the 21st century. Competitive uses and the prevalence of river basins and aquifers that extend across boundaries engender political tensions between communities, stakeholders and countries. Mitigating these conflicts and meeting water demands requires using existing resources more efficiently. The potential crises and conflicts arise when water is competed among multiple uses. For example, urban areas, environmental and recreational uses, agriculture, and energy production compete for scarce resources, not only in the Western U.S. but throughout much of the U.S. but also in many parts of the world. In addition to water availability issues, water quality related

  3. Macrominerals and Trace Element Requirements for Beef Cattle

    Science.gov (United States)

    Costa e Silva, Luiz Fernando; de Campos Valadares Filho, Sebastião; Engle, Terry Eugene; Rotta, Polyana Pizzi; Marcondes, Marcos Inácio; Silva, Flávia Adriane Sales; Martins, Edilane Costa; Tokunaga, Arnaldo Taishi

    2015-01-01

    Eighty-seven Nellore animals were utilized in this study to estimate net requirements for the maintenance and growth of beef cattle as well as the retention coefficients of 13 minerals: macrominerals (Ca, P, Mg, K, Na, and S) and trace elements (Cu, Fe, Mn, Se, Zn, Co, and Cr). The net requirements for maintenance and the true retention coefficient were estimated by using the regression between apparent retention and intake for each mineral. The net requirement for maintenance (μg/kg BW) and retention coefficients (%) were 163 and 85 for Cu, 2,097 and 53 for Fe, 32.3 and 24 for Mn, 3.72 and 48 for Se, 669 and 0.80 for Zn, 18.4 and 86 for Co, and 22.9 and 78 for Cr. The dietary requirements of macrominerals (g/kg DMI) were 5.12 for Ca, 2.38 for P, 0.96 for Mg, 2.40 for K, 0.79 for Na, and 1.47 for S. This is the first study using Nellore cattle to estimate mineral requirements; considering that Nellore cattle are the most common breed in Brazil and that Brazil is a major beef producer globally, this knowledge can help producers to improve animal performance by supplying the correct amount of minerals. PMID:26657049

  4. Writing requirements across nursing programs in Canada.

    Science.gov (United States)

    Andre, Jo-Anne D; Graves, Roger

    2013-02-01

    The emphasis on scholarship in nursing, demands for evidence-based practice, and attention to writing have raised the profile of academic writing within nursing curricula. This article provides a comprehensive review of English and writing course requirements across 81 English-language baccalaureate nursing programs in Canada. The data were gathered from a review of nursing programs and curriculum information from university and college Web sites. Of the 81 programs, 39 (48.1%) require neither an English literature course nor a writing course, 15 (18.5%) require an English literature course, and 32 (39.5%) require a writing course, including five programs that require a discipline-specific writing course. Discipline-specific writing courses appear to be useful adjuncts to writing-across-the-curriculum initiatives in nursing and will help students to develop the research and writing skills needed to succeed both academically and in a career in which nursing scholarship and evidence-informed practice are increasingly valued and expected. Copyright 2013, SLACK Incorporated.

  5. Modeling of rolling element bearing mechanics. Computer program user's manual

    Science.gov (United States)

    Greenhill, Lyn M.; Merchant, David H.

    1994-10-01

    This report provides the user's manual for the Rolling Element Bearing Analysis System (REBANS) analysis code which determines the quasistatic response to external loads or displacement of three types of high-speed rolling element bearings: angular contact ball bearings, duplex angular contact ball bearings, and cylindrical roller bearings. The model includes the defects of bearing ring and support structure flexibility. It is comprised of two main programs: the Preprocessor for Bearing Analysis (PREBAN) which creates the input files for the main analysis program, and Flexibility Enhanced Rolling Element Bearing Analysis (FEREBA), the main analysis program. This report addresses input instructions for and features of the computer codes. A companion report addresses the theoretical basis for the computer codes. REBANS extends the capabilities of the SHABERTH (Shaft and Bearing Thermal Analysis) code to include race and housing flexibility, including such effects as dead band and preload springs.

  6. Refining System Requirements to Program Specifications

    DEFF Research Database (Denmark)

    Olderog, Ernst-Ruediger; Ravn, Anders P.; Skakkebæk, Jens Ulrik

    1996-01-01

    A coherent and mathematically well-founded approach to the design ofreal-time and hybrid systems is presented.It covers requirementsanalysis and specification, design of controlling automatasatisfying the requirements, and derivation ofoccam-like communicating programs from these automata.......The generalized railroad crossing due to Heitmeyer and Lynchillustrates the approach.Requirements are analyzed within aconventional dynamic systems model of a plant, where states arefunctions of the reals, representing time. The requirements arespecified in an assumption-commitment style using Duration Calculus......,a real-time interval logic. Controlling real-time automata arespecified in the same formalism by elementaryconstraints on the plant states for each control state or phase.The Duration Calculus is used to verify that the control design refinesthe requirements.The real-time automata map smoothly...

  7. 7 CFR 1494.301 - Information required for program participation.

    Science.gov (United States)

    2010-01-01

    ... CREDIT CORPORATION, DEPARTMENT OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS EXPORT BONUS PROGRAMS Export Enhancement Program Operations § 1494.301 Information required for program participation...

  8. The Intelligent Data Understanding Element of NASA's Intelligent Systems Program

    Science.gov (United States)

    Coughlan, Joseph C.; Tilton, James C.; Rood, Richard (Technical Monitor)

    2002-01-01

    Within the NASA Intelligent Systems Program, the Intelligent Data Understanding (IDU) element develops techniques for transforming data into scientific understanding. Automating such tools is critical for space science, space-based earth science, and planetary exploration with onboard scientific data analysis. Intelligent data understanding (IDU) is about extracting meaning from large, diverse science and engineering databases, via autonomous techniques that transform very large datasets into understanding. The earth science community in particular needs new tools for analyzing multi-formatted and geographically distributed datasets and for identifying cause-effect relationships in the complex data. Research within the IDU program element seeks to automate data analysis tasks so that humans can focus on creative hypothesis generation and knowledge synthesis. It may also enable NASA space missions in which autonomous agents must generate knowledge and take actions, and missions where limited bandwidth permits transmission of only the most interesting scientific observations, summaries, and conclusions. Twenty-seven research projects are-currently funded.

  9. Universal Documentation System Handbook. Volume 2. Requirement Formats and Instructions; Program Introduction, Program Requirements Document/Operations Requirements

    Science.gov (United States)

    1989-08-01

    or the Air Force precedence rating. Program Status: State whether the program is proposed or approved and whether the PI is being subitted to obtain...instructions for Format 2CF,,. JT ( TATUOMATION ( ): indicate ’ tetbar each item number sukmitted is a requirement fc: - mort frcm the Support A.-ccy or

  10. Evaluation of a Nonlinear Finite Element Program - ABAQUS.

    Science.gov (United States)

    1983-03-15

    Elastic-plastic material and small deformation Material Properties: A Ramberg - Osgood stress-strain curve was assumed to represent the strain-hardening...NONLINEAR FINITE ELEMENT PROGRAM - ABAQUS T. Y. Chang S. M. Wang Department of Civil Engineering The University of Akron Akron, Ohio 44325 August 1, 1982... ABAQUS T. Y. Chang S. M. Wang Department of Civil Engineering The University of Akron Akron, Ohio 44325 August 1, 1982 (Revised on March 15, 1983

  11. 45 CFR 1356.83 - Reporting requirements and data elements.

    Science.gov (United States)

    2010-10-01

    ...-digit Federal Information Processing Standard (FIPS) code(s) that corresponds to the identity of the... element must be left blank. (21) Academic support. Academic supports are services designed to help a youth...: Academic counseling; preparation for a GED, including assistance in applying for or studying for a GED exam...

  12. 42 CFR 432.30 - Training programs: General requirements.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Training programs: General requirements. 432.30... SERVICES (CONTINUED) MEDICAL ASSISTANCE PROGRAMS STATE PERSONNEL ADMINISTRATION Training Programs; Subprofessional and Volunteer Programs § 432.30 Training programs: General requirements. (a) A State plan must...

  13. Lesson 3: Required Elements of a CROMERR Application

    Science.gov (United States)

    Cross-Media Electronic Reporting Regulation (CROMERR) 101: Fundamentals for States, Tribes, and Local Governments is designed for States, Tribes, and Local Governments that administer EPA-authorized programs under Title 40 of the Code of Federal Regulation

  14. 49 CFR 350.109 - What are the national program elements?

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 5 2010-10-01 2010-10-01 false What are the national program elements? 350.109... COMMERCIAL MOTOR CARRIER SAFETY ASSISTANCE PROGRAM General § 350.109 What are the national program elements? The national program elements include the following five activities: (a) Driver/vehicle inspections...

  15. Repetitive elements dynamics in cell identity programming, maintenance and disease

    KAUST Repository

    Bodega, Beatrice

    2014-12-01

    The days of \\'junk DNA\\' seem to be over. The rapid progress of genomics technologies has been unveiling unexpected mechanisms by which repetitive DNA and in particular transposable elements (TEs) have evolved, becoming key issues in understanding genome structure and function. Indeed, rather than \\'parasites\\', recent findings strongly suggest that TEs may have a positive function by contributing to tissue specific transcriptional programs, in particular as enhancer-like elements and/or modules for regulation of higher order chromatin structure. Further, it appears that during development and aging genomes experience several waves of TEs activation, and this contributes to individual genome shaping during lifetime. Interestingly, TEs activity is major target of epigenomic regulation. These findings are shedding new light on the genome-phenotype relationship and set the premises to help to explain complex disease manifestation, as consequence of TEs activity deregulation.

  16. 7 CFR 1493.420 - Information required for program participation.

    Science.gov (United States)

    2010-01-01

    ... GUARANTEE PROGRAMS CCC Supplier Credit Guarantee Program Operations § 1493.420 Information required for.... Government programs, contracts or agreements; and (6) A certification that: “I certify, to the best of my...

  17. 14 CFR 142.39 - Training program curriculum requirements.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Training program curriculum requirements... TRANSPORTATION (CONTINUED) SCHOOLS AND OTHER CERTIFICATED AGENCIES TRAINING CENTERS Aircrew Curriculum and Syllabus Requirements § 142.39 Training program curriculum requirements. Each training program curriculum...

  18. 29 CFR 37.97 - What are the required elements of a Conciliation Agreement?

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true What are the required elements of a Conciliation Agreement... § 37.97 What are the required elements of a Conciliation Agreement? A Conciliation Agreement must: (a... status of the corrective and remedial action; (e) Provide that the violation(s) will not recur; and (f...

  19. 14 CFR 91.1023 - Program operating manual requirements.

    Science.gov (United States)

    2010-01-01

    ... English language. If the program manager furnishes all or part of the manual in other than printed form... maintenance information and instructions in the English language. (h) If a program manager conducts aircraft... Ownership Operations Program Management § 91.1023 Program operating manual requirements. (a) Each program...

  20. Acquisition Program Transition Workshops: An Element of the DSMC Program Manager Mission Assistance Capability

    Science.gov (United States)

    2011-10-01

    Acquisition Sustainment =Decision Point =Milestone Review =Decision Point if PDR is not conducted before Milestone B ProgramA B Initiation) C IOC FOC...workshop deteriorating into a social event. 5.4 Further Detail Appendix A, Module 0, contains detailed planning elements for the pre-workshop agenda...brief Joint Charter, Issues and Actions PMs Establish Workshop Action Items Figure 5-1 Workshop Participants— More Attendees Means Program Socialization

  1. Robotic Surgery Simulator: Elements to Build a Training Program.

    Science.gov (United States)

    Tillou, Xavier; Collon, Sylvie; Martin-Francois, Sandrine; Doerfler, Arnaud

    2016-01-01

    Face, content, and construct validity of robotic surgery simulators were confirmed in the literature by several studies, but elements to build a training program are still lacking. The aim of our study was to validate a progressive training program and to assess according to prior surgical experience the amount of training needed with a robotic simulator to complete the program. Exercises using the Da Vinci Skill Simulator were chosen to ensure progressive learning. A new exercise could only be started if a minimal score of 80% was achieved in the prior one. The number of repetitions to achieve an exercise was not limited. We devised a "performance index" by calculating the ratio of the sum of scores for each exercise over the number of repetitions needed to complete the exercise with at least an 80% score. The study took place at the François Baclesse Cancer Center. Participants all work at the primary care university Hospital located next to the cancer center. A total of 32 surgeons participated in the study- 2 experienced surgeons, 8 junior and 8 senior residents in surgery, 6 registrars, and 6 attending surgeons. There was no difference between junior and senior residents, whereas the registrars had better results (p surgery console in a specific and progressive order enables rapid progress. The level of prior experience in laparoscopic surgery affects outcomes. More advanced laparoscopic expertise seems to slow down learning, surgeons having to "unlearn" to acquire a new technique. Copyright © 2016 Association of Program Directors in Surgery. Published by Elsevier Inc. All rights reserved.

  2. Requirements of a Better Secure Program Coding

    Directory of Open Access Journals (Sweden)

    Marius POPA

    2012-01-01

    Full Text Available Secure program coding refers to how manage the risks determined by the security breaches because of the program source code. The papers reviews the best practices must be doing during the software development life cycle for secure software assurance, the methods and techniques used for a secure coding assurance, the most known and common vulnerabilities determined by a bad coding process and how the security risks are managed and mitigated. As a tool of the better secure program coding, the code review process is presented, together with objective measures for code review assurance and estimation of the effort for the code improvement.

  3. Effectiveness and Successful Program Elements of SOAR’s Afterschool Programs

    Directory of Open Access Journals (Sweden)

    Janet L. Johnson

    2007-03-01

    Full Text Available Project SOAR provided after-school programs that afforded expanded learning opportunities to help students succeed in local public schools and to contribute to the general welfare of the community. Program components focused on building students’ academic skills and positive attitudes, aided by teachers, mentors, parent education, and local agencies. Instructional programs were conducted to help reduce drug use and violence. Activities included academic assistance, technology training, mentoring, service learning projects, and education in life skills and the arts. Parent involvement was encouraged. Behavioral and academic outcomes—especially at the high school level—were analyzed to determine program effectiveness regarding academic achievement, dropout rates, and rates and frequency of suspensions. Successful program elements and strategies are noted.

  4. Excision of the En/Spm transposable element of Zea mays requires two element-encoded proteins.

    OpenAIRE

    Frey, M.; Reinecke, J.; Grant, S; Saedler, H.; Gierl, A

    1990-01-01

    An excision assay system for En/Spm was developed in transgenic tobacco. The characteristics of excision and integration are similar to the natural system of Zea mays. In this transgenic model system two En/Spm encoded trans-acting functions, TNPA and TNPD, are required for excision. A biochemical model for transposition is proposed that might also be applicable to other transposable elements.

  5. 7 CFR 1466.8 - Program requirements.

    Science.gov (United States)

    2010-01-01

    ... attributable to livestock production, as measured at the national level. (e) NRCS will establish a national... OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS ENVIRONMENTAL QUALITY INCENTIVES PROGRAM... tenant of the land involved in agricultural production or forestry management, the applicant shall...

  6. 7 CFR 625.4 - Program requirements.

    Science.gov (United States)

    2010-01-01

    ... program based on the likelihood of successful restoration, enhancement, and protection of forest ecosystem... with, eligible landowners who voluntarily cooperate in the restoration and protection of forestlands... restoration plan, the effect of which is to restore, protect, enhance, maintain, and manage the habitat...

  7. National Waste Terminal Storage Program: critical element management concept. Volume I. Management summary

    Energy Technology Data Exchange (ETDEWEB)

    1977-05-01

    CEM is oriented towards identifying, quantifying and curtailing probable impediments to a program originating from both the internal and external program environments. Critical elements are defined as events, trends or conditions that could generate potential uncertainties in the program. The critical elements are broken down into components against which management action is initiated.

  8. 40 CFR 501.11 - Elements of a sludge management program submission.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Elements of a sludge management program submission. 501.11 Section 501.11 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Programs § 501.11 Elements of a sludge management program submission. (a) Any State that seeks to...

  9. 43 CFR 32.4 - Program operation requirements.

    Science.gov (United States)

    2010-10-01

    ... ESTABLISHING YOUNG ADULT CONSERVATION CORPS (YACC) PROGRAM § 32.4 Program operation requirements. (a) The State... Service Center (ASC), Bureau of Reclamation, P.O. Box 11568, Salt Lake City, Utah 84147 for enrollee pay... (FECA). (v) Safety and health: (A) Grantees shall assure that enrollees are not required or permitted to...

  10. 30 CFR 943.16 - Required program amendments.

    Science.gov (United States)

    2010-07-01

    ....16 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND ENFORCEMENT, DEPARTMENT OF THE INTERIOR PROGRAMS FOR THE CONDUCT OF SURFACE MINING OPERATIONS WITHIN EACH STATE TEXAS § 943.16 Required program amendments. Pursuant to 30 CFR 732.17(f)(1), Texas is required to submit to OSM by the specified date the...

  11. Do ICP-MS based methods fulfill the EU monitoring requirements for the determination of elements in our environment?

    Science.gov (United States)

    Tirez, Kristof; Vanhoof, Chris; Bronders, Jan; Seuntjens, Piet; Bleux, Nico; Berghmans, Patrick; De Brucker, Nicole; Vanhaecke, Frank

    2015-12-01

    Undoubtedly, the most important advance in the environmental regulatory monitoring of elements of the last decade is the widespread introduction of ICP-mass spectrometry (ICP-MS) due to standards developed by the European Committee for Standardization. The versatility of ICP-MS units as a tool for the determination of major, minor and trace elements (Al, As, Ba, Ca, Cd, Co, Cr, Cu, Fe, Hg, K, Mg, Mn, Mo, Na, Ni, P, Pb, Sb, Se, Sn, Ti, V and Zn) in surface water, groundwater, river sediment, topsoil, subsoil, fine particulates and atmospheric deposition is illustrated in this paper. Ranges of background concentrations for major, minor and trace elements obtained from a regional case study (Flanders, Belgium) are summarized for all of these environmental compartments and discussed in the context of a harmonized implementation of European regulatory monitoring requirements. The results were derived from monitoring programs in support of EU environmental quality directives and were based on a selection of (non-polluted) background locations. Because of the availability of ICP-MS instruments nowadays, it can be argued that the main hindrance for meeting the European environmental monitoring requirements is no longer the technical feasibility of analysis at these concentration levels, but rather (i) potential contamination during sampling and analysis, (ii) too limited implementation of quality control programs, validating the routinely applied methods (including sampling and low level verification) and (iii) lack of harmonization in reporting of the chemical environmental status between the individual member states.

  12. 36 CFR 1223.14 - What elements must a vital records program include?

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false What elements must a vital... RECORDS ADMINISTRATION RECORDS MANAGEMENT MANAGING VITAL RECORDS § 1223.14 What elements must a vital records program include? To achieve compliance with this section, an agency's vital records program must...

  13. 41 CFR 102-118.330 - What are the elements of an acceptable prepayment audit program?

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What are the elements of... Approved Program § 102-118.330 What are the elements of an acceptable prepayment audit program? An... before payment; (b) Comply with the Prompt Payment Act (31 U.S.C. 3901, et seq.); (c) Allow for your...

  14. 49 CFR 192.911 - What are the elements of an integrity management program?

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false What are the elements of an integrity management... Transmission Pipeline Integrity Management § 192.911 What are the elements of an integrity management program? An operator's initial integrity management program begins with a framework (see § 192.907) and...

  15. Reliability program requirements for Space and Terrestrial Nuclear Power Systems

    Energy Technology Data Exchange (ETDEWEB)

    1982-10-01

    The objectives of the reliability program requirements described in this report are (1) to provide contractors with an outline of the reliability requirements established by the Department of Energy (DOE) in the areas of design, development, production, testing, and acceptance of space and terrestrial nuclear systems hardware, and (2) to guide the contractor in meeting these requirements. This publication or particular portions of it is applicable as specified in the contract. Whether the contractors/subcontractors are subject to all the requirements or only to part of them will be specified by contract, program letter, or by the contract statement-of-work.

  16. Required Postdoctoral Education Programs in General Dentistry: Accreditation Issues.

    Science.gov (United States)

    Santangelo, Mario V.

    1987-01-01

    A review of the history and current status of both the predoctoral dental curriculum and general dentistry programs gives insight into the nature and scope of the movement to make postdoctoral dental education a requirement. (MSE)

  17. 01010000 01001100 01000001 01011001: Play Elements in Computer Programming

    Science.gov (United States)

    Breslin, Samantha

    2013-01-01

    This article explores the role of play in human interaction with computers in the context of computer programming. The author considers many facets of programming including the literary practice of coding, the abstract design of programs, and more mundane activities such as testing, debugging, and hacking. She discusses how these incorporate the…

  18. 24 CFR 401.400 - Required elements of a Restructuring Plan.

    Science.gov (United States)

    2010-04-01

    ... Urban Development (Continued) OFFICE OF HOUSING AND OFFICE OF MULTIFAMILY HOUSING ASSISTANCE RESTRUCTURING, DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT MULTIFAMILY HOUSING MORTGAGE AND HOUSING ASSISTANCE... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Required elements of a...

  19. 29 CFR 37.76 - What are the required elements of a recipient's discrimination complaint processing procedures?

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true What are the required elements of a recipient's... (WIA) Compliance Procedures § 37.76 What are the required elements of a recipient's discrimination... following elements: (1) Initial, written notice to the complainant that contains the following information...

  20. Program requirements for fellowship education in venous and lymphatic medicine.

    Science.gov (United States)

    Comerota, Anthony J; Min, Robert J; Rathbun, Suman W; Khilnani, Neil; Rooke, Thom; Wakefield, Thomas W; Carman, Teresa L; Lurie, Fedor; Vedantham, Suresh; Zimmet, Steven E

    2017-08-01

    Background In every field of medicine, comprehensive education should be delivered at the graduate level. Currently, no single specialty routinely provides a standardized comprehensive curriculum in venous and lymphatic disease. Method The American Board of Venous & Lymphatic Medicine formed a task force, made up of experts from the specialties of dermatology, family practice, interventional radiology, interventional cardiology, phlebology, vascular medicine, and vascular surgery, to develop a consensus document describing the program requirements for fellowship medical education in venous and lymphatic medicine. Result The Program Requirements for Fellowship Education in Venous and Lymphatic Medicine identify the knowledge and skills that physicians must master through the course of fellowship training in venous and lymphatic medicine. They also specify the requirements for venous and lymphatic training programs. The document is based on the Core Content for Training in Venous and Lymphatic Medicine and follows the ACGME format that all subspecialties in the United States use to specify the requirements for training program accreditation. The American Board of Venous & Lymphatic Medicine Board of Directors approved this document in May 2016. Conclusion The pathway to a vein practice is diverse, and there is no standardized format available for physician education and training. The Program Requirements for Fellowship Education in Venous and Lymphatic Medicine establishes educational standards for teaching programs in venous and lymphatic medicine and will facilitate graduation of physicians who have had comprehensive training in the field.

  1. Human Health Countermeasures (HHC) Element Management Plan: Human Research Program. Revision B

    Science.gov (United States)

    Norsk, Peter; Baumann, David

    2012-01-01

    NASA s Human Research Program (HRP) is an applied research and technology program within the Human Exploration and Operations Mission Directorate (HEOMD) that addresses human health and performance risk mitigation strategies in support of exploration missions. The HRP research and technology development is focused on the highest priority risks to crew health and safety with the goal of ensuring mission success and maintaining long-term crew health. Crew health and performance standards, defined by the NASA Chief Health and Medical Officer (CHMO), set the acceptable risk level for exploration missions. The HRP conducts research to inform these standards as well as provide deliverables, such as countermeasures, that ensure standards can be met to maximize human performance and mission success. The Human Health Countermeasures (HHC) Element was formed as part of the HRP to develop a scientifically-based, integrated approach to understanding and mitigating the health risks associated with human spaceflight. These health risks have been organized into four research portfolios that group similar or related risks. A fifth portfolio exists for managing technology developments and infrastructure projects. The HHC Element portfolios consist of: a) Vision and Cardiovascular; b) Exercise and Performance; c) Multisystem; d) Bone; and e) Technology and Infrastructure. The HHC identifies gaps associated with the health risks and plans human physiology research that will result in knowledge required to more fully understand risks and will result in validated countermeasures to mitigate risks.

  2. Phase 1 user instruction manual. A geological formation - drill string dynamic interaction finite element program (GEODYN)

    Energy Technology Data Exchange (ETDEWEB)

    Tinianow, M.A.; Rotelli, R.L. Jr.; Baird, J.A.

    1984-06-01

    User instructions for the GEODYN Interactive Finite Element Computer Program are presented. The program is capable of performing the analysis of the three-dimensional transient dynamic response of a Polycrystalline Diamond Compact Bit - Bit Sub arising from the intermittent contact of the bit with the downhole rock formations. The program accommodates non-linear, time dependent, loading and boundary conditions.

  3. Geological formation - drill string dynamic interaction finite-element program (GEODYN). Phase 1. Theoretical description

    Energy Technology Data Exchange (ETDEWEB)

    Baird, J.A.; Apostal, M.C.; Rotelli, R.L. Jr.; Tinianow, M.A.; Wormley, D.N.

    1984-06-01

    The Theoretical Description for the GEODYN interactive finite-element computer program is presented. The program is capable of performing the analysis of the three-dimensional transient dynamic response of a Polycrystalline Diamond Compact Bit-Bit Sub arising from the intermittent contact of the bit with the downhole rock formations. The program accommodates nonlinear, time-dependent, loading and boundary conditions.

  4. An Interactive Preprocessor Program with Graphics for a Three-Dimensional Finite Element Code.

    Science.gov (United States)

    Hamilton, Claude Hayden, III

    The development and capabilities of an interactive preprocessor program with graphics for an existing three-dimensional finite element code is presented. This preprocessor program, EDGAP3D, is designed to be used in conjunction with the Texas Three Dimensional Grain Analysis Program (TXCAP3D). The code presented in this research is capable of the…

  5. Steps to a HealthierUS Cooperative Agreement Program: foundational elements for program evaluation planning, implementation, and use of findings.

    Science.gov (United States)

    MacDonald, Goldie; Garcia, Danyael; Zaza, Stephanie; Schooley, Michael; Compton, Don; Bryant, Terry; Bagnol, Lulu; Edgerly, Cathy; Haverkate, Rick

    2006-01-01

    The Steps to a HealthierUS Cooperative Agreement Program (Steps Program) enables funded communities to implement chronic disease prevention and health promotion efforts to reduce the burden of diabetes, obesity, asthma, and related risk factors. At both the national and community levels, investment in surveillance and program evaluation is substantial. Public health practitioners engaged in program evaluation planning often identify desired outcomes, related indicators, and data collection methods but may pay only limited attention to an overarching vision for program evaluation among participating sites. We developed a set of foundational elements to provide a vision of program evaluation that informs the technical decisions made throughout the evaluation process. Given the diversity of activities across the Steps Program and the need for coordination between national- and community-level evaluation efforts, our recommendations to guide program evaluation practice are explicit yet leave room for site-specific context and needs. Staff across the Steps Program must consider these foundational elements to prepare a formal plan for program evaluation. Attention to each element moves the Steps Program closer to well-designed and complementary plans for program evaluation at the national, state, and community levels.

  6. Finite element strategies to satisfy clinical and engineering requirements in the field of percutaneous valves.

    Science.gov (United States)

    Capelli, Claudio; Biglino, Giovanni; Petrini, Lorenza; Migliavacca, Francesco; Cosentino, Daria; Bonhoeffer, Philipp; Taylor, Andrew M; Schievano, Silvia

    2012-12-01

    Finite element (FE) modelling can be a very resourceful tool in the field of cardiovascular devices. To ensure result reliability, FE models must be validated experimentally against physical data. Their clinical application (e.g., patients' suitability, morphological evaluation) also requires fast simulation process and access to results, while engineering applications need highly accurate results. This study shows how FE models with different mesh discretisations can suit clinical and engineering requirements for studying a novel device designed for percutaneous valve implantation. Following sensitivity analysis and experimental characterisation of the materials, the stent-graft was first studied in a simplified geometry (i.e., compliant cylinder) and validated against in vitro data, and then in a patient-specific implantation site (i.e., distensible right ventricular outflow tract). Different meshing strategies using solid, beam and shell elements were tested. Results showed excellent agreement between computational and experimental data in the simplified implantation site. Beam elements were found to be convenient for clinical applications, providing reliable results in less than one hour in a patient-specific anatomical model. Solid elements remain the FE choice for engineering applications, albeit more computationally expensive (>100 times). This work also showed how information on device mechanical behaviour differs when acquired in a simplified model as opposed to a patient-specific model.

  7. NASA'S Water Resources Element Within the Applied Sciences Program

    Science.gov (United States)

    Toll, David; Doorn, Bradley; Engman, Edwin

    2011-01-01

    The NASA Earth Systems Division has the primary responsibility for the Applied Science Program and the objective to accelerate the use of NASA science results in applications to help solve problems important to society and the economy. The primary goal of the NASA Applied Science Program is to improve future and current operational systems by infusing them with scientific knowledge of the Earth system gained through space-based observation, assimilation of new observations, and development and deployment of enabling technologies, systems, and capabilities. This paper discusses major problems facing water resources managers, including having timely and accurate data to drive their decision support tools. It then describes how NASA's science and space based satellites may be used to overcome this problem. Opportunities for the water resources community to participate in NASA's Water Resources Applications Program are described.

  8. The finite element analysis program MSC Marc/Mentat a first introduction

    CERN Document Server

    Öchsner, Andreas

    2016-01-01

    Based on simple examples, this book offers a short introduction to the general-purpose finite element program MSC Marc, a specialized program for non-linear problems (implicit solver) distributed by the MSC Software Corporation, which is commonly used in academia and industry. Today the documentation of all finite element programs includes a variety of step-by-step examples of differing complexity, and in addition, all software companies offer professional workshops on different topics. As such, rather than competing with these, the book focuses on providing simple examples, often single-element problems, which can easily be related to the theory that is discussed in finite element lectures. This makes it an ideal companion book to classical introductory courses on the finite element method.

  9. Elements of Quality in Agricultural Business Education Programs

    OpenAIRE

    Scott, Donald F.; Dobson, William D.

    1988-01-01

    This paper describes strategies for developing quality agribusiness management educational programs that include appropriate amounts of management and marketing subject matter, emphasize lifelong learning, avoid weak options, avoid mistakes made by business schools in the accreditation process, and hold potential for reversing the decline in undergraduate enrollments in agricultural economics.

  10. Snakes Have Feelings, Too: Elements of a Camp Snake Program.

    Science.gov (United States)

    Allen, Robert Ross

    2001-01-01

    A camp snake program can help campers overcome their fear of snakes, and people cannot truly enjoy nature when they carry a phobia about any one part of it. It can also help overcome prejudice by teaching truth and respect, instilling compassion, and helping campers develop empathy. Advice on catching, handling, identifying, keeping, and feeding…

  11. The Study Abroad Experience: A Crucial Element in Globalizing Business School Programs

    Science.gov (United States)

    Mangiero, George A.; Kraten, Michael

    2011-01-01

    Globalization is a fundamental reality of modern business practice. Participation in a study abroad program is a crucial element in helping students become well rounded global business leaders; it is an increasingly important element of a well rounded business curriculum. A semester or summer abroad, properly conceived and designed, can provide…

  12. Materials/manufacturing element of the Advanced Turbine Systems Program

    Energy Technology Data Exchange (ETDEWEB)

    Karnitz, M.A.; Holcomb, R.S.; Wright, I.G. [Oak Ridge National Lab., TN (United States)] [and others

    1995-10-01

    The technology based portion of the Advanced Turbine Systems Program (ATS) contains several subelements which address generic technology issues for land-based gas-turbine systems. One subelement is the Materials/Manufacturing Technology Program which is coordinated by DOE-Oak Ridge Operations and Oak Ridge National Laboratory (ORNL). The work in this subelement is being performed predominantly by industry with assistance from universities and the national laboratories. Projects in this subelement are aimed toward hastening the incorporation of new materials and components in gas turbines. A materials/manufacturing plan was developed in FY 1994 with input from gas turbine manufacturers, materials suppliers, universities, and government laboratories. The plan outlines seven major subelements which focus on materials issues and manufacturing processes. Work is currently under way in four of the seven major subelements. There are now major projects on coatings and process development, scale-up of single crystal airfoil manufacturing technology, materials characterization, and technology information exchange.

  13. Cleared for Launch - Lessons Learned from the OSIRIS-REx System Requirements Verification Program

    Science.gov (United States)

    Stevens, Craig; Adams, Angela; Williams, Bradley; Goodloe, Colby

    2017-01-01

    Requirements verification of a large flight system is a challenge. It is especially challenging for engineers taking on their first role in space systems engineering. This paper describes our approach to verification of the Origins, Spectral Interpretation, Resource Identification, Security-Regolith Explorer (OSIRIS-REx) system requirements. It also captures lessons learned along the way from developing systems engineers embroiled in this process. We begin with an overview of the mission and science objectives as well as the project requirements verification program strategy. A description of the requirements flow down is presented including our implementation for managing the thousands of program and element level requirements and associated verification data. We discuss both successes and methods to improve the managing of this data across multiple organizational interfaces. Our approach to verifying system requirements at multiple levels of assembly is presented using examples from our work at instrument, spacecraft, and ground segment levels. We include a discussion of system end-to-end testing limitations and their impacts to the verification program. Finally, we describe lessons learned that are applicable to all emerging space systems engineers using our unique perspectives across multiple organizations of a large NASA program.

  14. 7 CFR 205.620 - Requirements of State organic programs.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Requirements of State organic programs. 205.620 Section 205.620 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing Practices), DEPARTMENT OF AGRICULTURE (CONTINUED) ORGANIC FOODS PRODUCTION ACT PROVISIONS NATIONAL...

  15. Annual report of the wind characterisitics program element, April 1976--June 1977. [USA

    Energy Technology Data Exchange (ETDEWEB)

    Ramsdell, J. V.

    1977-07-01

    Battelle, Pacific Northwest Laboratories (PNL), has been providing technical and management support for the Wind Characteristics Program Element (WCPE) of the Wind Energy Conversion Program since April 1976. This first annual report to the Wind Systems Branch (WSB) of ERDA's Division of Solar Energy describes the technical progress within the Program Element from April 1976 through June 1977. Within the Wind Energy Conversion Program, the WCPE is a service element to provide information on wind characteristics to those involved in energy program planning, design and evaluation of performance of wind energy conversion systems(WECS), selection of sites for installation of WECS, and operation of WECS. To identify pertinent wind characteristics and collect and present that information in formats that are usable, the WCPE has been divided into four technical areas: Design and Performance Evaluation; Site Selection; Presiting Evaluation; and Planning and Operation.

  16. Cis-elements required for the demethylation of the mouse M-lysozyme downstream enhancer.

    Science.gov (United States)

    Schmitz, A; Short, M; Ammerpohl, O; Asbrand, C; Nickel, J; Renkawitz, R

    1997-08-15

    The mouse lysozyme downstream enhancer was previously colocalized with the DNase I-hypersensitive site in the chromatin of mature macrophages. This hypersensitive site was shown to be macrophage differentiation-dependent. Demethylation of CpG sequences within the enhancer is correlated with lysozyme expression in mature macrophages. Binding of the GABP heterotetrameric transcription factor to the enhancer core element (MLDE), only seen in vivo on the demethylated MLDE element in macrophages, is inhibited by DNA methylation. Here, we analyzed the DNA sequences required for demethylation. In electrophoretic mobility shift experiments we found that in addition to the complete methylated MLDE the hemimethylated form of the lower strand inhibits GABP binding as well. Therefore, GABP is unlikely to be the mediator of demethylation. In addition, we show by stable DNA transfections of methylated mouse lysozyme enhancer sequences that MLDE-flanking sequences are required for demethylation. We narrowed down these DNA elements to two short regions of 163 and 79 base pairs on either side of the MLDE, each of which is sufficient to mediate demethylation of the GABP site.

  17. Functionally distinct, sequence-specific replicator and origin elements are required for Drosophila chorion gene amplification.

    Science.gov (United States)

    Lu, L; Zhang, H; Tower, J

    2001-01-15

    To meet the demand for the rapid synthesis of chorion (eggshell) proteins, Drosophila ovarian follicle cells amplify the chromosomal loci containing the chorion gene clusters up to 60-fold. Amplification occurs by repeated firing of one or more origins located within each gene cluster. Deletion analyses of transgenic constructs derived from the third chromosome cluster have identified a 320-bp amplification control element (ACE3) required for amplification, as well as several stimulatory amplification enhancing regions (AERs). Two-dimensional (2D) gel analyses have identified multiple DNA replication initiation sites (origins) that partially overlap in location with ACE3 and the AERs. To further study sequence requirements for amplification, a vector was used in which transgenic constructs are protected from chromosomal position effects by flanking insulator elements, the suppressor Hairy-wing protein binding site (SHWBS). Using the buffered vector, the 320-bp ACE3 and an 884-bp element designated ori-beta were found to be necessary and sufficient for amplification. Two-dimensional gels revealed that ori-beta was acting as the origin. In contrast, origin activity could not be detected for ACE3. An insulator placed between ACE3 and ori-beta inhibited amplification, indicating that ACE3 activates ori-beta in cis. The results suggest that ACE3 acts as a replicator and support and extend the replicator model for the organization of metazoan chromosomal replicons.

  18. STARS: A general-purpose finite element computer program for analysis of engineering structures

    Science.gov (United States)

    Gupta, K. K.

    1984-01-01

    STARS (Structural Analysis Routines) is primarily an interactive, graphics-oriented, finite-element computer program for analyzing the static, stability, free vibration, and dynamic responses of damped and undamped structures, including rotating systems. The element library consists of one-dimensional (1-D) line elements, two-dimensional (2-D) triangular and quadrilateral shell elements, and three-dimensional (3-D) tetrahedral and hexahedral solid elements. These elements enable the solution of structural problems that include truss, beam, space frame, plane, plate, shell, and solid structures, or any combination thereof. Zero, finite, and interdependent deflection boundary conditions can be implemented by the program. The associated dynamic response analysis capability provides for initial deformation and velocity inputs, whereas the transient excitation may be either forces or accelerations. An effective in-core or out-of-core solution strategy is automatically employed by the program, depending on the size of the problem. Data input may be at random within a data set, and the program offers certain automatic data-generation features. Input data are formatted as an optimal combination of free and fixed formats. Interactive graphics capabilities enable convenient display of nodal deformations, mode shapes, and element stresses.

  19. Background and elements of the linkage between the Brazilian school feeding program and family farming.

    Science.gov (United States)

    Schwartzman, Flavia; Mora, Claudia Andrea Rodriguez; Bogus, Claudia Maria; Villar, Betzabeth Slater

    2017-12-18

    Since 2009, legislation of the National School Feeding Program of Brazil (PNAE) institutionalizes its linkage with family farming as it establishes the requirement that at least 30% out of the total financial resources allocated by the federal government to the states and municipalities for school feeding must be used in the purchase of products directly from this sector. This study analyzes the process of drafting this legislation, focusing on the elements related to the procurement from family farming, through a historical contextualization, and it also presents a graphical representation with the main elements of this linkage: its objectives, target population, actions implemented and expected results. Actors involved with the drafting of the legislation were interviewed. The analyses show that the procurement from family farming is a far-reaching initiative in terms of the concept, execution and results. It has also showed that a strong articulation between the actors and institutions of the different sectors involved is critical to its success. The education, agriculture, planning, procurement and civil society sectors should work articulately at national, state and local level. The results of this study demonstrate that initiatives like this, of institutional procurement from family farming, which are currently being implemented in several countries, constitute as an important strategy of food and nutrition security, for the fulfillment of the human right to adequate food and the promotion of long-term sustainable development.

  20. 10 CFR Appendix D to Part 436 - Energy Program Conservation Elements

    Science.gov (United States)

    2010-01-01

    ... 436 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION FEDERAL ENERGY MANAGEMENT AND PLANNING PROGRAMS Pt... present management systems incorporate these elements. (1) Top Management Control. Top management must have a personal and sustained commitment to the program, provide active direction and motivation, and...

  1. FOCUS: Essential Elements of Quality for State-Funded Preschool Programs

    Science.gov (United States)

    New Mexico Public Education Department, 2016

    2016-01-01

    The "FOCUS: Essential Elements of Quality, New Mexico's Tiered Quality Rating and Improvement System (TQRIS)," provides early childhood program personnel with the criteria, tools, and resources they need to improve the quality of their program. These quality improvements focus on children's growth, development, and learning--so that each…

  2. Heavy Ion Inertial Fusion Energy: Summaries of Program Elements

    Energy Technology Data Exchange (ETDEWEB)

    Friedman, A; Barnard, J J; Kaganovich, I; Seidl, P A; Briggs, R J; Faltens, A; Kwan, J W; Lee, E P; Logan, B G

    2011-02-28

    The goal of the Heavy Ion Fusion (HIF) Program is to apply high-current accelerator technology to IFE power production. Ion beams of mass {approx}100 amu and kinetic energy {>=} 1 GeV provide efficient energy coupling into matter, and HIF enjoys R&D-supported favorable attributes of: (1) the driver, projected to be robust and efficient; see 'Heavy Ion Accelerator Drivers.'; (2) the targets, which span a continuum from full direct to full indirect drive (and perhaps fast ignition), and have metal exteriors that enable injection at {approx}10 Hz; see 'IFE Target Designs'; (3) the near-classical ion energy deposition in the targets; see 'Beam-Plasma Interactions'; (4) the magnetic final lens, robust against damage; see 'Final Optics-Heavy Ion Beams'; and (5) the fusion chamber, which may use neutronically-thick liquids; see 'Liquid-Wall Chambers.' Most studies of HIF power plants have assumed indirect drive and thick liquid wall protection, but other options are possible.

  3. Long-Term Stewardship Program Science and Technology Requirements

    Energy Technology Data Exchange (ETDEWEB)

    Joan McDonald

    2002-09-01

    Many of the United States’ hazardous and radioactively contaminated waste sites will not be sufficiently remediated to allow unrestricted land use because funding and technology limitations preclude cleanup to pristine conditions. This means that after cleanup is completed, the Department of Energy will have long-term stewardship responsibilities to monitor and safeguard more than 100 sites that still contain residual contamination. Long-term stewardship encompasses all physical and institutional controls, institutions, information, and other mechanisms required to protect human health and the environment from the hazards remaining. The Department of Energy Long-Term Stewardship National Program is in the early stages of development, so considerable planning is still required to identify all the specific roles and responsibilities, policies, and activities needed over the next few years to support the program’s mission. The Idaho National Engineering and Environmental Laboratory was tasked with leading the development of Science and Technology within the Long-Term Stewardship National Program. As part of that role, a task was undertaken to identify the existing science and technology related requirements, identify gaps and conflicts that exist, and make recommendations to the Department of Energy for future requirements related to science and technology requirements for long-term stewardship. This work is summarized in this document.

  4. Expanding Dress Code Requirements in the Doctor of Pharmacy Program.

    Science.gov (United States)

    Naughton, Cynthia A; Schweiger, Teresa A; Angelo, Lauren B; Lea Bonner, C; Dhing, Conrad W; Farley, Joel F

    2016-06-25

    Although the use of a professional dress code is standard practice across colleges and schools of pharmacy during introductory and advanced pharmacy practice experiences, requiring professional attire is not applied consistently during the didactic portion of students' education. There are arguments for and against the adoption of a professional dress code throughout the entire doctor of pharmacy program, including the classroom setting. Given uncertainty regarding the potential benefits and challenges that may arise from adopting a professional dress code in the didactic portion of a student pharmacist's education, it is perhaps not surprising that programs adopt disparate policies regarding its use. This exploration was conducted as part of a series of debates held in conjunction with the American Association of Colleges of Pharmacy's (AACP) Academic Leadership Fellows Program (ALFP) and was presented at the 2015 AACP Interim Meeting on February 7, 2015.

  5. Battling memory requirements of array programming through streaming

    DEFF Research Database (Denmark)

    Kristensen, Mads Ruben Burgdorff; Avery, James Emil; Blum, Troels

    2016-01-01

    A barrier to efficient array programming, for example in Python/NumPy, is that algorithms written as pure array operations completely without loops, while most efficient on small input, can lead to explosions in memory use. The present paper presents a solution to this problem using array streaming......, implemented in the automatic parallelization high-performance framework Bohrium. This makes it possible to use array programming in Python/NumPy code directly, even when the apparent memory requirement exceeds the machine capacity, since the automatic streaming eliminates the temporary memory overhead...... by performing calculations in per-thread registers. Using Bohrium, we automatically fuse, JIT-compile, and execute NumPy array operations on GPGPUs without modification to the user programs. We present performance evaluations of three benchmarks, all of which show dramatic reductions in memory use from...

  6. Requirements for a geometry programming language for CFD applications

    Science.gov (United States)

    Gentry, Arvel E.

    1992-01-01

    A number of typical problems faced by the aerodynamicist in using computational fluid dynamics are presented to illustrate the need for a geometry programming language. The overall requirements for such a language are illustrated by examples from the Boeing Aero Grid and Paneling System (AGPS). Some of the problems in building such a system are also reviewed along with suggestions as to what to look for when evaluating new software problems.

  7. Spatio-temporal requirements for transposable element piRNA-mediated silencing during Drosophila oogenesis.

    Science.gov (United States)

    Dufourt, Jérémy; Dennis, Cynthia; Boivin, Antoine; Gueguen, Nathalie; Théron, Emmanuelle; Goriaux, Coline; Pouchin, Pierre; Ronsseray, Stéphane; Brasset, Emilie; Vaury, Chantal

    2014-02-01

    During Drosophila oogenesis, transposable element (TE) repression involves the Piwi-interacting RNA (piRNA) pathway which ensures genome integrity for the next generation. We developed a transgenic model to study repression of the Idefix retrotransposon in the germline. Using a candidate gene KD-approach, we identified differences in the spatio-temporal requirements of the piRNA pathway components for piRNA-mediated silencing. Some of them (Aub, Vasa, Spn-E) are necessary in very early stages of oogenesis within the germarium and appear to be less important for efficient TE silencing thereafter. Others (Piwi, Ago3, Mael) are required at all stages of oogenesis. Moreover, during early oogenesis, in the dividing cysts within the germarium, Idefix anti-sense transgenes escape host control, and this is associated with very low piwi expression. Silencing of P-element-based transgenes is also strongly weakened in these cysts. This region, termed the 'Piwiless pocket' or Pilp, may ensure that new TE insertions occur and are transmitted to the next generation, thereby contributing to genome dynamics. In contrast, piRNA-mediated silencing is strong in germline stem cells in which TE mobilization is tightly repressed ensuring the continued production of viable germline cysts.

  8. 25 CFR 36.99 - Are immunizations required for residential program students?

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Are immunizations required for residential program... SITUATIONS Homeliving Programs Program Requirements § 36.99 Are immunizations required for residential program students? Each student must have all immunizations required by State, local, or tribal governments...

  9. Rare earth elements as a by-catch of sedimentary deposits. Exploration program of rare earth elements; Selten Erd Elemente als Beifang sedimentaerer Lagerstaetten. Erkundungsprogramm Selten Erd Elemente

    Energy Technology Data Exchange (ETDEWEB)

    Linhardt, E.; Gebhardt, A. (comps.)

    2014-02-15

    The increasing demand for rare earth elements (REE) in the field of ''green technologies'' on the one hand and the shortage of raw materials on the world markets on the other hand confronted also Bavaria as an industrial location with growing supply problems in these ''high tech raw materials''. The aim of exploration was the clarification of the feedstock REE potential of heavy mineral concentrates which are obtained in the industrial extraction and processing of sand and kaolin in existing extraction operations in northern Bavaria as by catch and are potentially winnable or marketable. The in-depth investigation enabled the potential of found rare earth elements and other high-tech metal oxides that can be classified as very likely find it in terms of an economic recovery. [German] Der zunehmende Bedarf an Selten Erd Elementen (SEE) im Bereich der ''Gruenen Technologien'' zum Einen sowie die Rohstoffverknappung auf den Weltmaerkten zum Anderen konfrontiert auch Bayern als Industriestandort mit wachsenden Versorgungsproblemen bei diesen ''high tech-Grundstoffen''. Ziel der Erkundung war die Klaerung des rohstofflichen SEE-Potenzials von Schwermineralkonzentraten, die bei der grosstechnischen Gewinnung und Aufbereitung von Sand und Kaolin in vorhandenen Gewinnungsbetrieben Nordbayerns als Beifang anfallen und potenziell gewinn- bzw. vermarktbar sind. Im Zuge der Untersuchung konnten nutzbare Potenziale von Selten Erd Elementen und anderen high-tech - Metalloxiden gefunden werden, die sehr wahrscheinlich als fuendig im Hinblick auf eine wirtschaftliche Gewinnung eingestuft werden koennen.

  10. Modified Delphi Consensus to Suggest Key Elements of Stepping On Falls Prevention Program.

    Science.gov (United States)

    Mahoney, Jane E; Clemson, Lindy; Schlotthauer, Amy; Mack, Karin A; Shea, Terry; Gobel, Vicki; Cech, Sandy

    2017-01-01

    Falls among older adults result in substantial morbidity and mortality. Community-based programs have been shown to decrease the rate of falls. In 2007, the Centers for Disease Control and Prevention funded a research study to determine how to successfully disseminate the evidence-based fall prevention program (Stepping On) in the community setting. As the first step for this study, a panel of subject matter experts was convened to suggest which parts of the Stepping On fall prevention program were considered key elements, which could not be modified by implementers. Older adult fall prevention experts from the US, Canada, and Australia participated in a modified Delphi technique process to suggest key program elements of Stepping On. Forty-four experts were invited to ensure that the panel of experts would consist of equal numbers of physical therapists, occupational therapists, geriatricians, exercise scientists, and public health researchers. Consensus was determined by percent of agreement among panelists. A Rasch analysis of item fit was conducted to explore the degree of diversity and/or homogeneity of responses across our panelists. The Rasch analysis of the 19 panelists using fit statistics shows there was a reasonable and sufficient range of diverse perspectives (Infit MnSQ 1.01, Z score -0.1, Outfit MnSQ 0.96, Z score -0.2 with a separation of 4.89). Consensus was achieved that these elements were key: 17 of 18 adult learning elements, 11 of 22 programming, 12 of 15 exercise, 7 of 8 upgrading exercises, 2 of 4 peer co-leader's role, and all of the home visits, booster sessions, group leader's role, and background and training of group leader elements. The top five key elements were: (1) use plain language, (2) develop trust, (3) engage people in what is meaningful and contextual for them, (4) train participants for cues in self-monitoring quality of exercises, and (5) group leader learns about exercises and understands how to progress them. The Delphi

  11. Requirements engineering and program synthesis: Mutually exclusive or synergistic?

    Science.gov (United States)

    Lowry, M. R.

    2001-01-01

    There has often been a clash within the formal methods community between early life-cycle proponents such as the requirements engineering community and late life-cycle proponents such as the program synthesis community. This talk will first characterize these positions and their underlying assumptions, and then expose a common set of problems and approaches. The talk will then propose an integrated life-cycle framework, and expound on its potential benefits. Technical challenges to achieving this integrated life-cycle framework will be described, as well as some preliminary work towards that goal.

  12. What are the elements required to improve exposure estimates in life cycle assessments?

    DEFF Research Database (Denmark)

    Ernstoff, Alexi; Rosenbaum, Ralph K.; Margni, Manuele

    2016-01-01

    In this study we aim to identify and discuss priority elements required to improve exposure estimates in Life cycle assessment (LCA). LCA aims at guiding decision-support to minimize damages on resources, humans, and ecosystems which incur via providing society with products and services. Potential...... human toxicity and ecosystem toxicity of chemicals posed by different product life cycle stages are characterized in the life cycle impact assessment (LCIA) phase. Exposure and effect quantification as part of LCIA toxicity characterization faces numerous challenges related to inventory analysis (e......). There are many relevant areas for improving exposure quantification in LCIA. We explore prioritising future work based on investigating existing mitigation efforts, observed damages, and potential for (irreversible) harm to ensure LCIA covers at least the most relevant concerns faced by societies today regarding...

  13. AlterBBN: A program for calculating the BBN abundances of the elements in alternative cosmologies

    CERN Document Server

    Arbey, Alexandre

    2012-01-01

    We describe AlterBBN, a public C program for evaluating the abundances of the elements generated by Big-Bang nucleosynthesis (BBN). This program enables the user to compute the abundances of the elements in the standard model of cosmology, and additionally provides possibilities to alter the assumptions of the cosmological model in order to study their consequences on the abundances of the elements. In particular the baryon-to-photon ratio and the effective number of neutrinos, as well as the expansion rate and the entropy content of the Universe during BBN can be modified in AlterBBN. Such features allow the user to test the cosmological models by confronting them to BBN constraints. A presentation of the physics of BBN and the features of AlterBBN is provided here under the form of a manual.

  14. Application of the Single Hardening Model in the Finite Element Program ABAQUS

    DEFF Research Database (Denmark)

    Jakobsen, Kim Parsberg

    that several conceptual models, describing the non-linear and irreversible behaviour of soil, have been developed over the last three decades few of them are accessible in commercial finite element programs. In the present study the Single Hardening Model, that is a time independent elastoplastic constitutive...

  15. Ultimate limit state design of sheet pile walls by finite elements and nonlinear programming

    DEFF Research Database (Denmark)

    Krabbenhøft, Kristian; Damkilde, Lars; Krabbenhøft, Sven

    2005-01-01

    as a nonlinear programming problem where the yield moment of the wall is minimized subject to equilibrium and yield conditions. The finite element discretization used enables exact fulfillment of these conditions and thus, according to the lower bound theorem, the solutions are safe....

  16. Ultimate Limit State Design Of Sheet Pile Walls By Finite Elements And Nonlinear Programming

    DEFF Research Database (Denmark)

    Krabbenhøft, Kristian; Damkilde, Lars; Krabbenhøft, Sven

    2005-01-01

    as a nonlinear programming problem where the yield moment of the wall is minimized subject to equilibrium and yield conditions. The finite element discretization used enables exact fulfillment of these conditions and thus, according to the lower bound theorem, the solutions are safe...

  17. Elements of Mathematics, Book O: Intuitive Background. Chapter 16, Introduction to Computer Programming.

    Science.gov (United States)

    Exner, Robert; And Others

    The sixteen chapters of this book provide the core material for the Elements of Mathematics Program, a secondary sequence developed for highly motivated students with strong verbal abilities. The sequence is based on a functional-relational approach to mathematics teaching, and emphasizes teaching by analysis of real-life situations. This text is…

  18. Pest rodents as the essential elements of Mycobacterium bovis controlling programs

    Directory of Open Access Journals (Sweden)

    Elahe Moradi

    2015-01-01

    Discussion: This study was unable to track tangible evidence of tuberculosis transmission by mice. Hence to prove this hypothesis, further studies are advised. However, it was found that mice are potentially a reservoir of zoonotic pathogens, and therefore its importance in this regard must be considered as an effective element of any controlling program.

  19. Workplace Violence Training Programs for Health Care Workers: An Analysis of Program Elements.

    Science.gov (United States)

    Arbury, Sheila; Hodgson, Michael; Zankowski, Donna; Lipscomb, Jane

    2017-06-01

    Commercial workplace violence (WPV) prevention training programs differ in their approach to violence prevention and the content they present. This study reviews 12 such programs using criteria developed from training topics in the Occupational Safety and Health Administration's (OSHA) Guidelines for Preventing Workplace Violence for Healthcare and Social Service Workers and a review of the WPV literature. None of the training programs addressed all the review criteria. The most significant gap in content was the lack of attention to facility-specific risk assessment and policies. To fill this gap, health care facilities should supplement purchased training programs with specific training in organizational policies and procedures, emergency action plans, communication, facility risk assessment, and employee post-incident debriefing and monitoring. Critical to success is a dedicated program manager who understands risk assessment, facility clinical operations, and program management and evaluation.

  20. Development and program implementation of elements for identification of the electromagnet condition for movable element position control

    Science.gov (United States)

    Leukhin, R. I.; Shaykhutdinov, D. V.; Shirokov, K. M.; Narakidze, N. D.; Vlasov, A. S.

    2017-02-01

    Developing the experimental design of new electromagnetic constructions types in engineering industry enterprises requires solutions of two major problems: regulator’s parameters setup and comprehensive testing of electromagnets. A weber-ampere characteristic as a data source for electromagnet condition identification was selected. Present article focuses on development and implementation of the software for electromagnetic drive control system based on the weber-ampere characteristic measuring. The software for weber-ampere characteristic data processing based on artificial neural network is developed. Results of the design have been integrated into the program code in LabVIEW environment. The license package of LabVIEW graphic programming was used. The hardware is chosen and possibility of its use for control system implementation was proved. The trained artificial neural network defines electromagnetic drive effector position with minimal error. Developed system allows to control the electromagnetic drive powered by the voltage source, the current source and hybrid sources.

  1. Light Water Reactor Sustainability Program. Digital Architecture Requirements

    Energy Technology Data Exchange (ETDEWEB)

    Thomas, Kenneth [Idaho National Lab. (INL), Idaho Falls, ID (United States); Oxstrand, Johanna [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2015-03-01

    The Digital Architecture effort is a part of the Department of Energy (DOE) sponsored Light-Water Reactor Sustainability (LWRS) Program conducted at Idaho National Laboratory (INL). The LWRS program is performed in close collaboration with industry research and development (R&D) programs that provides the technical foundations for licensing and managing the long-term, safe, and economical operation of current nuclear power plants (NPPs). One of the primary missions of the LWRS program is to help the U.S. nuclear industry adopt new technologies and engineering solutions that facilitate the continued safe operation of the plants and extension of the current operating licenses. Therefore, a major objective of the LWRS program is the development of a seamless digital environment for plant operations and support by integrating information from plant systems with plant processes for nuclear workers through an array of interconnected technologies. In order to get the most benefits of the advanced technology suggested by the different research activities in the LWRS program, the nuclear utilities need a digital architecture in place to support the technology. A digital architecture can be defined as a collection of information technology (IT) capabilities needed to support and integrate a wide-spectrum of real-time digital capabilities for nuclear power plant performance improvements. It is not hard to imagine that many processes within the plant can be largely improved from both a system and human performance perspective by utilizing a plant wide (or near plant wide) wireless network. For example, a plant wide wireless network allows for real time plant status information to easily be accessed in the control room, field workers’ computer-based procedures can be updated based on the real time plant status, and status on ongoing procedures can be incorporated into smart schedules in the outage command center to allow for more accurate planning of critical tasks. The goal

  2. 75 FR 64322 - Notice of Formula Allocations and Program Requirements for Neighborhood Stabilization Program...

    Science.gov (United States)

    2010-10-19

    ... URBAN DEVELOPMENT Notice of Formula Allocations and Program Requirements for Neighborhood Stabilization... Assistance, Department of Housing and Urban Development, 451 Seventh Street, SW., Room 7286, Washington, DC... combined index score for the grantee's identified target geography that is not less than the lesser of 17...

  3. Nerva Fuel Element Development Program Summary Report - July 1966 through June 1972 Extrusion Studies

    Energy Technology Data Exchange (ETDEWEB)

    Napier, J. M.

    1973-09-21

    This part of the completion report pertaining to the NERVA graphite fuel element program covers data collected during the extrusion studies. The physical properties of the fuel element reached the following values: coefficient of thermal expansion (CTE) - 7.0 x 10-6/o C (25 - l,OOOo C); modulus of elasticity - 1.5 x lo6 psi; flexural strength - - 8,000 psi; ultimate strain to failure - 5,500 pidin; good thermal stress resistance. Matrices were produced which could be vapor coated with crack-free films of zirconium carbide. The CTE of the matrix was almost equal to the CTE of the zirconium carbide coating.

  4. MAPVAR - A Computer Program to Transfer Solution Data Between Finite Element Meshes

    Energy Technology Data Exchange (ETDEWEB)

    Wellman, G.W.

    1999-03-01

    MAPVAR, as was the case with its precursor programs, MERLIN and MERLIN II, is designed to transfer solution results from one finite element mesh to another. MAPVAR draws heavily from the structure and coding of MERLIN II, but it employs a new finite element data base, EXODUS II, and offers enhanced speed and new capabilities not available in MERLIN II. In keeping with the MERLIN II documentation, the computational algorithms used in MAPVAR are described. User instructions are presented. Example problems are included to demonstrate the operation of the code and the effects of various input options.

  5. Government-to-private sector energy programs: Identification of common elements leading to successful implementation

    Science.gov (United States)

    Stockton, Keith M.

    This dissertation examines six distinct government energy programs implemented in the United States during the last three decades. A common element within these programs is an attempt by government to drive commercialization of energy technologies leading to changes in energy production or consumptive behavior. We seek to understand the factors that lead to success or failure of these programs with two goals in mind. The first is theoretical in that we test a hypothesis that market-based energy programs have substantially higher success rates than command-and-control programs. The second goal is operational in nature, in which we desire to identify common factors within energy programs that lead either to program success or to failure. We investigate and evaluate three market-based and three command-and-control energy programs. The market-based programs include the federal Corporate Average Fuel Economy and Sulfur Dioxide Emissions Control programs as well as Colorado's Amendment 37. The command-and-control programs include the federal Synthetic Fuels Corporation and Corn Based Ethanol programs as well as Colorado's Solar Electric Power program. We conduct the analysis of each program based on composite methodology derived from leading academics within the Policy Sciences. From our research findings, we conclude that both market-based and command-and-control programs can achieve their legislative goals and objectives, resulting in permanent changes in energy production or consumptive behavior. However, we also find that the economic efficiency is the differentiator between market-based and command-and-control programs. Market-based programs, because of the inherent flexibility, allow participants to react to changing economic and/or technical conditions. In contrast, command-and-control programs lack such flexibility and often result in economic inefficiency when economic conditions change. The financial incentives incorporated in the three command

  6. Glucose signalling pathway controls the programmed ribosomal frameshift efficiency in retroviral-like element Ty3 in Saccharomyces cerevisiae.

    Science.gov (United States)

    Türkel, Sezai; Kaplan, Güliz; Farabaugh, Philip J

    2011-11-01

    Ty3 elements of S. cerevisiae contain two overlapping coding regions, GAG3 and POL3, which are functional homologues of retroviral gag and pol genes, respectively. Pol3 is translated as a Gag3-Pol3 fusion protein dependent on a +1 programmed frameshift at a site with the overlap between the two genes. We show that the Ty3 frameshift frequency varies up to 10-fold in S. cerevisiae cells depending on carbon source. Frameshift efficiency is significantly lower in cells growing on glucose as carbon source than in cells growing on poor alternative carbon sources (glycerol/lactate or galactose). Our results indicate that Ty3 programmed ribosomal frameshift efficiency in response to glucose signalling requires two protein kinases: Snf1p and cAMP-dependent protein kinase A (PKA). Increased frameshifting on alternative carbon sources also appears to require cytoplasmic localization of Snf1p, mediated by the Sip2p protein. In addition to the two required protein kinases, our results implicate that Stm1p, a ribosome-associated protein involved in nutrient sensing, is essential for the carbon source-dependent regulation of Ty3 frameshifting. These data indicate that Ty3 programmed ribosomal frameshift is not a constitutive process but that it is regulated in response to the glucose-signalling pathway. Copyright © 2011 John Wiley & Sons, Ltd.

  7. 20 CFR 665.330 - Are the NAFTA-TAA program requirements for rapid response also required activities?

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Are the NAFTA-TAA program requirements for... WORKFORCE INVESTMENT ACT Rapid Response Activities § 665.330 Are the NAFTA-TAA program requirements for... WIA are made available to workers who, under the NAFTA Implementation Act (Public Law 103-182), are...

  8. Annual Report of the Wind Characteristics Program Element for the Period April 1976 Through June 1977

    Energy Technology Data Exchange (ETDEWEB)

    Elderkin, C. E.; Ramsdell, J. V.

    1977-07-01

    The Wind Characteristics Program Element (WCPE) is a service element to provide meteorological information to other parts of the Wind Energy Conversion Program. In this role, the WCPE has as its general objective acceleration of the development, commercialization and utilization of reliable and economically viable wind energy conversion systems (WECS). This report discusses the work undertaken in the areas of design and performance evaluation, site selection, and presiting evaluation from April 1976 through June 1977. A systematic evaluation of wind descriptors has begun in the Design and Performance Evaluation Program Areas and is leading to the preparation of handbooks of meteorological information for use in design and performance evaluation. A conceptual framework has been established within the Site Selection Program Area that clearly defines the relationships between siting tools. The Presiting Evaluation Program Area is involved in the identification of large areas of high wind energy potential throughout the United States, and in the determination of wind characteristics related to the economic viability of wind energy conversion within these areas.

  9. Effect of a three-month football training program on trace element ...

    African Journals Online (AJOL)

    This study was conducted to examine the effects of a three-month football training program on some trace elements in the serum in male kids aged between eight and twelve years. The study registered eight boys whose mean age was 10.25 ± 0.75 years, mean height was 138.63 ± 3.28 cm and mean weight was 32.13 ...

  10. Quantum Biology at the Cellular Level - elements of the research program

    OpenAIRE

    Bordonaro, Michael; Ogryzko, Vasily

    2013-01-01

    Quantum Biology is emerging as a new field at the intersection between fundamental physics and biology, promising novel insights into the nature and origin of biological order. We discuss several elements of QBCL (Quantum Biology at Cellular Level), a research program designed to extend the reach of quantum concepts to higher than molecular levels of biological organization. Key words. decoherence, macroscopic superpositions, basis-dependence, formal superposition, non-classical correlations,...

  11. MP Salsa: a finite element computer program for reacting flow problems. Part 1--theoretical development

    Energy Technology Data Exchange (ETDEWEB)

    Shadid, J.N.; Moffat, H.K.; Hutchinson, S.A.; Hennigan, G.L.; Devine, K.D.; Salinger, A.G.

    1996-05-01

    The theoretical background for the finite element computer program, MPSalsa, is presented in detail. MPSalsa is designed to solve laminar, low Mach number, two- or three-dimensional incompressible and variable density reacting fluid flows on massively parallel computers, using a Petrov-Galerkin finite element formulation. The code has the capability to solve coupled fluid flow, heat transport, multicomponent species transport, and finite-rate chemical reactions, and to solver coupled multiple Poisson or advection-diffusion- reaction equations. The program employs the CHEMKIN library to provide a rigorous treatment of multicomponent ideal gas kinetics and transport. Chemical reactions occurring in the gas phase and on surfaces are treated by calls to CHEMKIN and SURFACE CHEMKIN, respectively. The code employs unstructured meshes, using the EXODUS II finite element data base suite of programs for its input and output files. MPSalsa solves both transient and steady flows by using fully implicit time integration, an inexact Newton method and iterative solvers based on preconditioned Krylov methods as implemented in the Aztec solver library.

  12. Virtual garden computer program for use in exploring the elements of biodiversity people want in cities.

    Science.gov (United States)

    Shwartz, Assaf; Cheval, Helene; Simon, Laurent; Julliard, Romain

    2013-08-01

    Urban ecology is emerging as an integrative science that explores the interactions of people and biodiversity in cities. Interdisciplinary research requires the creation of new tools that allow the investigation of relations between people and biodiversity. It has been established that access to green spaces or nature benefits city dwellers, but the role of species diversity in providing psychological benefits remains poorly studied. We developed a user-friendly 3-dimensional computer program (Virtual Garden [www.tinyurl.com/3DVirtualGarden]) that allows people to design their own public or private green spaces with 95 biotic and abiotic features. Virtual Garden allows researchers to explore what elements of biodiversity people would like to have in their nearby green spaces while accounting for other functions that people value in urban green spaces. In 2011, 732 participants used our Virtual Garden program to design their ideal small public garden. On average gardens contained 5 different animals, 8 flowers, and 5 woody plant species. Although the mathematical distribution of flower and woody plant richness (i.e., number of species per garden) appeared to be similar to what would be expected by random selection of features, 30% of participants did not place any animal species in their gardens. Among those who placed animals in their gardens, 94% selected colorful species (e.g., ladybug [Coccinella septempunctata], Great Tit [Parus major], and goldfish), 53% selected herptiles or large mammals, and 67% selected non-native species. Older participants with a higher level of education and participants with a greater concern for nature designed gardens with relatively higher species richness and more native species. If cities are to be planned for the mutual benefit of people and biodiversity and to provide people meaningful experiences with urban nature, it is important to investigate people's relations with biodiversity further. Virtual Garden offers a standardized

  13. 45 CFR 235.62 - State plan requirements for training programs.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 2 2010-10-01 2010-10-01 false State plan requirements for training programs. 235... ADMINISTRATION OF FINANCIAL ASSISTANCE PROGRAMS § 235.62 State plan requirements for training programs. A State plan under title I, IV-A, X, XIV, or XVI (AABD) of the Act must provide for a training program for...

  14. 7 CFR 1493.30 - Information required for program participation.

    Science.gov (United States)

    2010-01-01

    ... CREDIT CORPORATION, DEPARTMENT OF AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS CCC EXPORT CREDIT GUARANTEE PROGRAMS CCC Export Credit Guarantee Program (GSM-102) and CCC Intermediate Export Credit... export sale contemplated by the applicant; (5) A certified statement describing the applicant's...

  15. Sobriety as an admission criterion for transitional housing: a multi-site comparison of programs with a sobriety requirement to programs with no sobriety requirement.

    Science.gov (United States)

    Tsai, Jack; Rosenheck, Robert A; Kasprow, Wesley J; McGuire, James F

    2012-10-01

    This study examined whether homeless clients enrolled in transitional housing programs that required sobriety (SR) as an admission criterion have outcomes comparable to clients enrolled in programs that did not require sobriety (NSR) as an admission criterion. A total of 1062 military veterans in 40 transitional housing programs funded by the United States Department of Veterans Affairs were grouped based on whether they were in SR or NSR programs and followed over a one-year period after program discharge. Participants in SR and NSR programs were compared on their ratings of the social climate of the program, and housing and psychosocial outcomes. Participants in SR programs reported more days housed and better psychosocial outcomes than participants in NSR programs, although the differences were small and there were no differences in ratings of their social climate. Both participants in SR and NSR programs showed improvements on most outcomes after discharge from transitional housing. There were no significant differences in outcomes between participants actively abusing substances at program entry compared to those who were not. Requiring sobriety as an admission criterion in transitional housing made only a small difference in housing outcomes post-discharge. Further study is needed to determine whether requiring sobriety at admission in transitional housing is necessary for successful client outcomes. Published by Elsevier Ireland Ltd.

  16. Study on reduction of accessory horsepower requirements. Program summary report

    Energy Technology Data Exchange (ETDEWEB)

    Lefferts, C.H.

    1977-06-15

    The objective of this program was to define, evaluate and develop automotive accessory systems to minimize engine power consumption and significantly improve fuel economy. All tasks have been completed and the program objectives have been accomplished. Information is presented on each phase of the program which involved: conceptual design to recommended component improvement and accessory drive systems; performance and sizing analyses; detail design and specifications; fabrication, and performance testing; evaluation of integrated hybrid drive, improved accessories; and an advanced air conditioning concept.

  17. 30 CFR 938.16 - Required regulatory program amendments.

    Science.gov (United States)

    2010-07-01

    ... effective than 30 CFR 800.21(e)(1) by requiring that the provisions related to valuation of collateral bonds... requirement that the application include the address for each permit held by a related entity or company, and...

  18. COYOTE : a finite element computer program for nonlinear heat conduction problems. Part I, theoretical background.

    Energy Technology Data Exchange (ETDEWEB)

    Glass, Micheal W.; Hogan, Roy E., Jr.; Gartling, David K.

    2010-03-01

    The need for the engineering analysis of systems in which the transport of thermal energy occurs primarily through a conduction process is a common situation. For all but the simplest geometries and boundary conditions, analytic solutions to heat conduction problems are unavailable, thus forcing the analyst to call upon some type of approximate numerical procedure. A wide variety of numerical packages currently exist for such applications, ranging in sophistication from the large, general purpose, commercial codes, such as COMSOL, COSMOSWorks, ABAQUS and TSS to codes written by individuals for specific problem applications. The original purpose for developing the finite element code described here, COYOTE, was to bridge the gap between the complex commercial codes and the more simplistic, individual application programs. COYOTE was designed to treat most of the standard conduction problems of interest with a user-oriented input structure and format that was easily learned and remembered. Because of its architecture, the code has also proved useful for research in numerical algorithms and development of thermal analysis capabilities. This general philosophy has been retained in the current version of the program, COYOTE, Version 5.0, though the capabilities of the code have been significantly expanded. A major change in the code is its availability on parallel computer architectures and the increase in problem complexity and size that this implies. The present document describes the theoretical and numerical background for the COYOTE program. This volume is intended as a background document for the user's manual. Potential users of COYOTE are encouraged to become familiar with the present report and the simple example analyses reported in before using the program. The theoretical and numerical background for the finite element computer program, COYOTE, is presented in detail. COYOTE is designed for the multi-dimensional analysis of nonlinear heat conduction

  19. Practical Considerations in Financing Required Postdoctoral General Dentistry Programs.

    Science.gov (United States)

    Myall, Robert W. T.

    1987-01-01

    General and specific issues to be considered in examining program financing options are discussed, including perceptions of patient needs, faculty's role in patient care, public health policy, links with the patient care delivery system, the patient mix, resident stipends, and program management alternatives. (MSE)

  20. 41 CFR 128-1.8006 - Seismic Safety Program requirements.

    Science.gov (United States)

    2010-07-01

    ... Component Seismic Safety Coordinator shall ensure that an individual familiar with seismic design provisions... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Seismic Safety Program... Management Regulations System (Continued) DEPARTMENT OF JUSTICE 1-INTRODUCTION 1.80-Seismic Safety Program...

  1. Program design by a multidisciplinary team. [for structural finite element analysis on STAR-100 computer

    Science.gov (United States)

    Voigt, S.

    1975-01-01

    The use of software engineering aids in the design of a structural finite-element analysis computer program for the STAR-100 computer is described. Nested functional diagrams to aid in communication among design team members were used, and a standardized specification format to describe modules designed by various members was adopted. This is a report of current work in which use of the functional diagrams provided continuity and helped resolve some of the problems arising in this long-running part-time project.

  2. Trace elements in grasses and legumes in relation to cow requirements

    DEFF Research Database (Denmark)

    Elgersma, Anjo; Søegaard, Karen; Jensen, Søren Krogh

    Trace elements are usually allocated as inorganic supplements in dairy cow feeding to avoid deficiency. To increase self-sufficiency ofmicronutrients on farms, knowledge and choice of plant species could help to improve and balance the mineral status of cow diets. Effects of grassland species...

  3. 30 CFR 250.455 - What are the general requirements for a drilling fluid program?

    Science.gov (United States)

    2010-07-01

    ... drilling fluid program? 250.455 Section 250.455 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT... Gas Drilling Operations Drilling Fluid Requirements § 250.455 What are the general requirements for a drilling fluid program? You must design and implement your drilling fluid program to prevent the loss of...

  4. 30 CFR 77.1706 - First aid training program; minimum requirements.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false First aid training program; minimum... OF UNDERGROUND COAL MINES Miscellaneous § 77.1706 First aid training program; minimum requirements. (a) All first aid training programs required under the provisions of §§ 77.1703 and 77.1704 shall...

  5. Health Education Doctoral Degree Programs: A Review of Admission and Graduation Requirements

    Science.gov (United States)

    Dagenhard, Paige; Castor, Thomas; Brookins-Fisher, Jodi; Thompson, Amy

    2016-01-01

    A study of university graduate bulletins was conducted to determine admission and graduation requirements for doctoral degree programs in Health Education. Thirty-nine programs were identified. From that list, programs were delimited to PhD and DrPH degrees in Health Education or had required core courses in Health Education. Seventeen programs…

  6. Expanding Dress Code Requirements in the Doctor of Pharmacy Program

    National Research Council Canada - National Science Library

    Cynthia A Naughton

    2017-01-01

    "1 We initiated this article to address both the potential advantages and disadvantages to implementing a dress code to facilitate a discussion surrounding this topic and to assist programs that might...

  7. 47 CFR 76.75 - Specific EEO program requirements.

    Science.gov (United States)

    2010-10-01

    ... informing prospective employees that discrimination because of race, color, religion, national origin, age..., religion, age, or gender. (i) An employment unit shall use recruitment sources for each vacancy sufficient... programming distributor employment issues, including conventions, career days, workshops, and similar...

  8. 20 CFR 655.1111 - Element I-What hospitals are eligible to participate in the H-1C program?

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Element I-What hospitals are eligible to... I—What hospitals are eligible to participate in the H-1C program? (a) The first attestation element... ADMINISTRATION, DEPARTMENT OF LABOR TEMPORARY EMPLOYMENT OF FOREIGN WORKERS IN THE UNITED STATES What...

  9. Expanding Dress Code Requirements in the Doctor of Pharmacy Program

    National Research Council Canada - National Science Library

    Naughton, Cynthia A; Schweiger, Teresa A; Angelo, Lauren B; Lea Bonner, C; Dhing, Conrad W; Farley, Joel F

    2016-01-01

    Although the use of a professional dress code is standard practice across colleges and schools of pharmacy during introductory and advanced pharmacy practice experiences, requiring professional attire...

  10. Strategy of Philosophy Education to Develop Thinking Children : An Analysis of Curriculum for Early Elementally School in the Program “Philosophy for Children”

    OpenAIRE

    Fukui, Suguru

    2014-01-01

    In this study, the author explores the strategy of the philosophy education to develop thinking children by analyzing of structures of the curriculum for early elementally school in the program “Philosophy for Children”. The curriculum consists of a storybook and instructional manual. The curriculum is structured so that children are made aware of problematical concepts in their own life, and then required to practice judge relations of concepts on their own experience. Children discover good...

  11. 20 CFR 667.300 - What are the reporting requirements for Workforce Investment Act programs?

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false What are the reporting requirements for Workforce Investment Act programs? 667.300 Section 667.300 Employees' Benefits EMPLOYMENT AND TRAINING... Reporting Requirements § 667.300 What are the reporting requirements for Workforce Investment Act programs...

  12. 25 CFR 170.606 - How do legislation and procurement requirements affect the IRR Program?

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false How do legislation and procurement requirements affect... Miscellaneous Provisions § 170.606 How do legislation and procurement requirements affect the IRR Program? Other legislation and procurement requirements apply to the IRR Program as shown in the following table. Legislation...

  13. 25 CFR 170.450 - What archeological and environmental requirements must the IRR Program meet?

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false What archeological and environmental requirements must... Reservation Roads Program Facilities Environmental and Archeological Requirements § 170.450 What archeological and environmental requirements must the IRR Program meet? (a) The archeological and environmental...

  14. 50 CFR 86.72 - Do any other Federal requirements apply to this program?

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 6 2010-10-01 2010-10-01 false Do any other Federal requirements apply to... INFRASTRUCTURE GRANT (BIG) PROGRAM How States Manage Grants § 86.72 Do any other Federal requirements apply to this program? For administrative requirements not covered under these specific guidelines, check 43 CFR...

  15. Do informed consent documents for chiropractic clinical research studies meet readability level recommendations and contain required elements: a descriptive study.

    Science.gov (United States)

    Twist, Elissa; Lawrence, Dana J; Salsbury, Stacie A; Hawk, Cheryl

    2014-01-01

    Informed consent documents (ICD) in research are designed to educate research participants about the nature of the research project in which he or she may participate. United States (US) law requires the documents to contain specific elements present and be written in a way that is understandable to research participants. The purpose of this research is to determine if ICDs from randomized controlled trials conducted at chiropractic colleges meet recommended readability standards and contain the 13 content items required by US law. This study was approved by Palmer College of Chiropractic's IRB #2012-12-3-T and was conducted between December 3, 2012 and February 14, 2013. We contacted the research directors of five chiropractic colleges that have received federal funding supporting their clinical research. A total of 13 informed consent documents from four chiropractic colleges were analyzed using the Flesch-Kincaid measurement. We assigned a grade-level readability score to the document based on the average of three separate grade level scores conducted on the three largest uninterrupted blocks of text. Content of the 13 ICDs was assessed using a 13-element checklist. A point was given for every element present in the document, giving a score range of "0, no elements are present", to "13, all elements are present." The mean Flesch-Kincaid grade level readability was 10.8 (range 7.2 -14.0). Our sample had a mean readability score 2.8 grade levels above the generally-accepted US average reading level. Content varied among the 13 informed consent forms, ranging from only nine elements present in one document to all 13 required in five documents. Additionally, we collated the risks presented in each document. These results strongly suggest that chiropractic clinical researchers are not developing ICDs at a readability level congruent with the national average acceptable level. The low number of elements in some of the informed consent documents raises concern that not

  16. Insulin inhibition of glucocorticoid-stimulated gene transcription: requirement for an insulin response element?

    Science.gov (United States)

    Pierreux, C E; Rousseau, G G; Lemaigre, F P

    1999-01-25

    The glucocorticoid hormone receptor binds to regulatory elements of target genes and activates transcription through interactions with coactivators. For a subset of genes, glucocorticoid receptor activity is inhibited by insulin. The present paper analyzes recent data on the molecular mechanisms whereby insulin exerts this antiglucocorticoid effect. Two models are proposed. In the first model insulin controls the activity of an insulin-responsive factor bound to an insulin-responsive DNA element. In a second model, insulin targets a non-DNA bound coactivator of the glucocorticoid receptor. Here, the gene-specificity of the effect of insulin is conferred by the combined action of the glucocorticoid receptor, of DNA-bound transcription factors and of coactivators, which form a higher order structure that binds to a DNA sequence called glucocorticoid/insulin responsive unit.

  17. STARS: An Integrated, Multidisciplinary, Finite-Element, Structural, Fluids, Aeroelastic, and Aeroservoelastic Analysis Computer Program

    Science.gov (United States)

    Gupta, K. K.

    1997-01-01

    A multidisciplinary, finite element-based, highly graphics-oriented, linear and nonlinear analysis capability that includes such disciplines as structures, heat transfer, linear aerodynamics, computational fluid dynamics, and controls engineering has been achieved by integrating several new modules in the original STARS (STructural Analysis RoutineS) computer program. Each individual analysis module is general-purpose in nature and is effectively integrated to yield aeroelastic and aeroservoelastic solutions of complex engineering problems. Examples of advanced NASA Dryden Flight Research Center projects analyzed by the code in recent years include the X-29A, F-18 High Alpha Research Vehicle/Thrust Vectoring Control System, B-52/Pegasus Generic Hypersonics, National AeroSpace Plane (NASP), SR-71/Hypersonic Launch Vehicle, and High Speed Civil Transport (HSCT) projects. Extensive graphics capabilities exist for convenient model development and postprocessing of analysis results. The program is written in modular form in standard FORTRAN language to run on a variety of computers, such as the IBM RISC/6000, SGI, DEC, Cray, and personal computer; associated graphics codes use OpenGL and IBM/graPHIGS language for color depiction. This program is available from COSMIC, the NASA agency for distribution of computer programs.

  18. 34 CFR 379.42 - What are the special requirements pertaining to the Client Assistance Program?

    Science.gov (United States)

    2010-07-01

    ... Client Assistance Program? 379.42 Section 379.42 Education Regulations of the Offices of the Department... requirements pertaining to the Client Assistance Program? Each grantee under a program covered by this part... availability and purposes of the State's Client Assistance Program, including information on seeking assistance...

  19. Dissection of the beta-globin replication-initiation region reveals specific requirements for replicator elements during gene amplification.

    Directory of Open Access Journals (Sweden)

    Naoya Okada

    Full Text Available Gene amplification plays a pivotal role in malignant transformation of human cells. A plasmid with both a mammalian replication-initiation region (IR/origin/replicator and a nuclear matrix-attachment region (MAR is spontaneously amplified in transfected cells by a mechanism that involves amplification at the extrachromosomal site, followed by amplification at the chromosomal arm, ultimately generating a long homogeneously staining region (HSR. Several observations suggest that replication initiation from IR sequences might mediate amplification. To test this idea, we previously dissected c-myc and DHFR IRs to identify the minimum sequence required to support amplification. In this study, we applied an improved analysis that discriminates between two amplification steps to the ß-globin RepP IR, which contains separate elements already known to be essential for initiation on the chromosome arm. The IR sequence was required at least for the extrachromosomal amplification step. In addition to the vector-encoded MAR, amplification also required an AT-rich region and a MAR-like element, consistent with the results regarding replicator activity on the chromosome. However, amplification did not require the AG-rich tract necessary for replicator activity, but instead required a novel sequence containing another AG-rich tract. The differential sequence requirement might be a consequence of extrachromosomal replication.

  20. Annual report of the Wind Characteristics Program Element, October 1979-September 1980

    Energy Technology Data Exchange (ETDEWEB)

    Wendell, L.L.; Barchet, W.R.; Connell, J.R.; Miller, A.H.; Pennell, W.T.; Renne, D.S.

    1981-09-01

    This annual report briefly describes the technical progress within each segment of the WCPE from October 1979 through September 1980. It includes the progress accomplished directly by the Pacific Northwest Laboratory (PNL) and by subcontractors funded directly by DOE or through PNL. To expedite the management of the activities to produce the required information, the WCPE has been divided into three program areas: Wind Energy Prospecting, Support for Design and Operations, and Site Evaluation. Accomplishments in each of these program areas provide a highlight of WCPE activities in FY 1980.

  1. Snake River Sockeye Salmon Captive Broodstock Program; Hatchery Element, 2001 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    Kline, Paul A.; Willard, Catherine; Baker, Dan J. (Idaho Department of Fish and Game, Boise, ID)

    2003-08-01

    On November 20, 1991, the National Marine Fisheries Service listed Snake River sockeye salmon Oncorhynchus nerka as endangered under the Endangered Species Act of 1973. In 1991, the Idaho Department of Fish and Game, the Shoshone-Bannock Tribes, and the National Marine Fisheries Service initiated efforts to conserve and rebuild populations in Idaho. Initial steps to recover sockeye salmon included the establishment of a captive broodstock program at the Idaho Department of Fish and Game Eagle Fish Hatchery. Sockeye salmon broodstock and culture responsibilities are shared with the National Marine Fisheries Service at two locations adjacent to Puget Sound in Washington State. Activities conducted by the Shoshone-Bannock Tribes and the National Marine Fisheries Service are reported under separate cover. Idaho Department of Fish and Game monitoring and evaluation activities of captive broodstock program fish releases (annual report to the Bonneville Power Administration for the research element of the program) are also reported separately. Captive broodstock program activities conducted between January 1, 2001 and December 31, 2001 for the hatchery element of the program are presented in this report. In 2001, 26 anadromous sockeye salmon returned to the Sawtooth Basin. Twenty-three of these adults were captured at adult weirs located on the upper Salmon River and on Redfish Lake Creek. Three of the anadromous sockeye salmon that returned were observed below the Sawtooth Fish Hatchery weir and allowed to migrate upstream volitionally (following the dismantling of the weir on October 12, 2001). Nine anadromous adults were incorporated into the captive broodstock program spawning design in 2001. The remaining adults were released to Redfish Lake for natural spawning. Based on their marks, returning adult sockeye salmon originated from a variety of release options. Two sockeye salmon females from the anadromous group and 152 females from the brood year 1998 captive

  2. Requirements UML Tool (RUT) Expanded for Extreme Programming (CI02)

    Science.gov (United States)

    McCoy, James R.

    2003-01-01

    A procedure for capturing and managing system requirements that incorporates XP user stories. Because costs associated with identifying problems in requirements increase dramatically over the lifecycle of a project, a method for identifying sources of software risks in user stories is urgently needed. This initiative aims to determine a set of guide-lines for user stories that will result in high-quality requirement. To further this initiative, a tool is needed to analyze user stories that can assess the quality of individual user stories, detect sources cf software risk's, produce software metrics, and identify areas in user stories that can be improved.

  3. Automated evaluation of matrix elements between contracted wavefunctions: A Mathematica version of the FRODO program

    Science.gov (United States)

    Angeli, C.; Cimiraglia, R.

    2013-02-01

    A symbolic program performing the Formal Reduction of Density Operators (FRODO), formerly developed in the MuPAD computer algebra system with the purpose of evaluating the matrix elements of the electronic Hamiltonian between internally contracted functions in a complete active space (CAS) scheme, has been rewritten in Mathematica. New version : A program summaryProgram title: FRODO Catalogue identifier: ADV Y _v2_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/ADVY_v2_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.: 3878 No. of bytes in distributed program, including test data, etc.: 170729 Distribution format: tar.gz Programming language: Mathematica Computer: Any computer on which the Mathematica computer algebra system can be installed Operating system: Linux Classification: 5 Catalogue identifier of previous version: ADV Y _v1_0 Journal reference of previous version: Comput. Phys. Comm. 171(2005)63 Does the new version supersede the previous version?: No Nature of problem. In order to improve on the CAS-SCF wavefunction one can resort to multireference perturbation theory or configuration interaction based on internally contracted functions (ICFs) which are obtained by application of the excitation operators to the reference CAS-SCF wavefunction. The previous formulation of such matrix elements in the MuPAD computer algebra system, has been rewritten using Mathematica. Solution method: The method adopted consists in successively eliminating all occurrences of inactive orbital indices (core and virtual) from the products of excitation operators which appear in the definition of the ICFs and in the electronic Hamiltonian expressed in the second quantization formalism. Reasons for new version: Some years ago we published in this journal a couple of papers [1, 2

  4. Responsible Transition of New Materiel Requirements into Programs of Record

    Science.gov (United States)

    2013-03-01

    transitions through Milestone B, or is introduced after Milestone B through a change in requirements or demands for an accelerated schedule. The last two of...additional requirement or schedule acceleration is needed. Rather, the Services must go back to the ends, ways, and means and make adjustments to bring...for Lasting, 39. 35 John P. Kotter , “Leading Change: Why Transformation Efforts Fail,” Harvard Business Review, January 2007, 8. 36 U.S. Government

  5. 24 CFR 570.489 - Program administrative requirements.

    Science.gov (United States)

    2010-04-01

    ... procedures for units of general local government, based on full and open competition. Methods of procurement... aggregate of the state's annual grant, program income received by units of general local government (whether retained by the unit of general local government or paid to the State) and funds reallocated by HUD to the...

  6. 48 CFR 2803.104-70 - Ethics program training requirements.

    Science.gov (United States)

    2010-10-01

    ... General IMPROPER BUSINESS PRACTICES AND PERSONAL CONFLICTS OF INTEREST Safeguards 2803.104-70 Ethics... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Ethics program training... should be coordinated with the Department's Ethics Official, who is responsible for developing agency...

  7. 75 FR 7370 - Closed Captioning of Video Programming; Closed Captioning Requirements for Digital Television...

    Science.gov (United States)

    2010-02-19

    ... Television Receivers AGENCY: Federal Communications Commission. ACTION: Final rule; announcement of effective... Closed Captioning of Video Programming; Closed Captioning Requirements for Digital Television Receivers...

  8. Requiring sobriety at program entry: impact on outcomes in supported transitional housing for homeless veterans.

    Science.gov (United States)

    Schinka, John A; Casey, Roger J; Kasprow, Wesley; Rosenheck, Robert A

    2011-11-01

    An important distinction in models of housing for the homeless is whether programs that require abstinence prior to program admission produce better outcomes than unrestricted programs. Data from a large transitional housing program were used to compare client characteristics of and outcomes from programs requiring abstinence at admission and programs not requiring abstinence. The U.S. Department of Veterans Affairs (VA) Northeast Program Evaluation Center provided records of individuals who were admitted into, and discharged from, the VA Grant and Per Diem program in 2003-2005. Records contained information from intake interviews, program discharge information, and descriptions of provider characteristics. Analyses were based on 3,188 veteran records, 1,250 from programs requiring sobriety at admission and 1,938 from programs without a sobriety requirement. Group differences were examined with t tests and chi square analyses; predictors of program outcome were determined with logistic regression. Individuals using drugs or alcohol at program admission had more problematic histories, as indicated by several general health and mental health variables, and shorter program stays. There were significant differences between groups in the frequency of program completion, recidivism for homelessness, and employment on program discharge, but effect sizes for these analyses were uniformly small and of questionable importance. Regression analyses did not find meaningful support for the importance of sobriety on program entry on any of the outcome measures. The results add evidence to the small body of literature supporting the position that sobriety on program entry is not a critical variable in determining outcomes for individuals in transitional housing programs.

  9. Element Partition Trees For H-Refined Meshes to Optimize Direct Solver Performance. Part I: Dynamic Programming

    KAUST Repository

    AbouEisha, Hassan M.

    2017-07-13

    We consider a class of two-and three-dimensional h-refined meshes generated by an adaptive finite element method. We introduce an element partition tree, which controls the execution of the multi-frontal solver algorithm over these refined grids. We propose and study algorithms with polynomial computational cost for the optimization of these element partition trees. The trees provide an ordering for the elimination of unknowns. The algorithms automatically optimize the element partition trees using extensions of dynamic programming. The construction of the trees by the dynamic programming approach is expensive. These generated trees cannot be used in practice, but rather utilized as a learning tool to propose fast heuristic algorithms. In this first part of our paper we focus on the dynamic programming approach, and draw a sketch of the heuristic algorithm. The second part will be devoted to a more detailed analysis of the heuristic algorithm extended for the case of hp-adaptive

  10. Snake River Sockeye Salmon Captive Broodstock Program; Hatchery Element, 2002 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    Willard, Catherine; Baker, Dan J.; Heindel, Jeff A. (Idaho Department of Fish and Game, Boise, ID)

    2003-12-01

    On November 20, 1991, the National Marine Fisheries Service listed Snake River sockeye salmon Oncorhynchus nerka as endangered under the Endangered Species Act of 1973. In 1991, the Idaho Department of Fish and Game, the Shoshone-Bannock Tribes, and the National Marine Fisheries Service initiated efforts to conserve and rebuild populations in Idaho. Initial steps to recover sockeye salmon included the establishment of a captive broodstock program at the Idaho Department of Fish and Game Eagle Fish Hatchery. Sockeye salmon broodstock and culture responsibilities are shared with the National Oceanic and Atmospheric Administration at two locations adjacent to Puget Sound in Washington State. Activities conducted by the Shoshone-Bannock Tribes and the National Oceanic and Atmospheric Administration are reported under separate cover. Idaho Department of Fish and Game monitoring and evaluation activities of captive broodstock program fish releases (annual report to the Bonneville Power Administration for the research element of the program) are also reported separately. Captive broodstock program activities conducted between January 1, 2002 and December 31, 2002 for the hatchery element of the program are presented in this report. n 2002, 22 anadromous sockeye salmon returned to the Sawtooth Valley. Fifteen of these adults were captured at adult weirs located on the upper Salmon River and on Redfish Lake Creek. Seven of the anadromous sockeye salmon that returned were observed below the Sawtooth Fish Hatchery weir and allowed to migrate upstream volitionally (following the dismantling of the weir on September 30, 2002). All adult returns were released to Redfish Lake for natural spawning. Based on their marks, returning adult sockeye salmon originated from a variety of release options. Sixty-six females from brood year 1999 and 28 females from brood year 2000 captive broodstock groups were spawned at the Eagle Hatchery in 2002. Spawn pairings produced approximately 65

  11. Do Baseline Requirements Hinder Trades in Water Quality Programs?

    OpenAIRE

    Ghosh, Gaurav; Ribaudo, Marc; Shortle, James

    2009-01-01

    The Environmental Protection Agency and the U.S. Department of Agriculture are promoting point/nonpoint trading as a way of reducing the costs of meeting water quality goals while giving nonpoint sources a larger role in meeting those goals. Farms can create offsets or credits in a point/nonpoint trading program by implementing management practices such as conservation tillage, nutrient management, and buffer strips. To be eligible to sell credits, farmers must first comply with baseline requ...

  12. Do baseline requirements hinder trades in water quality trading programs?

    OpenAIRE

    Ribaudo, Marc; Ghosh, Gaurav S.; Shortle, James S.

    2009-01-01

    The Environmental Protection Agency and the U.S. Department of Agriculture are promoting point/nonpoint trading as a way of reducing the costs of meeting water quality goals while giving nonpoint sources a larger role in meeting those goals. Farms can create offsets or credits in a point/nonpoint trading program by implementing management practices such as conservation tillage, nutrient management, and buffer strips. To be eligible to sell credits, farmers must first comply with baseline requ...

  13. 30 CFR 925.16 - Required program amendments.

    Science.gov (United States)

    2010-07-01

    ...) (p) By May 10, 2002, Missouri shall amend its program as follows: (1)-(3) (4) At 10 CSR 40-3.240 by... regulations at 30 CFR 817.95(a). (5)-(19) (20) At 10 CSR 40-8.070(2)(C)1.A(II)(a) and (b) to revise the definition of cumulative measurement period to provide appropriate dates for the end of the period for which...

  14. Part A - Advanced turbine systems. Part B - Materials/manufacturing element of the Advanced Turbine Systems Program

    Energy Technology Data Exchange (ETDEWEB)

    Karnitz, M.A.

    1996-06-01

    The DOE Offices of Fossil Energy and Energy Efficiency and Renewable Energy have initiated a program to develop advanced turbine systems for power generation. The objective of the Advanced Turbine Systems (ATS) Program is to develop ultra-high efficiency, environmentally superior, and cost competitive gas turbine systems for utility and industrial applications. One of the supporting elements of the ATS Program is the Materials/Manufacturing Technologies Task. The objective of this element is to address the critical materials and manufacturing issues for both industrial and utility gas turbines.

  15. Correct Requirements, A Factor for Success in Major Acquisition Programs

    Science.gov (United States)

    2008-06-01

    Recycling, and Waste Prevention EX. ORD NO. 13148; Greening the Government through Leadership in Environmental Management EX. ORD. NO.11514...electronic resource] :NPS-GSBPP-06- 007. Rost , J. (2006). Are "best practices" requirements documents a myth? IEEE Software, 23(3), 104. SIGSOFT 2006

  16. Development of an Automated Requirements Management System for the Space Station Freedom Program

    Science.gov (United States)

    Giffin, Geoff

    1989-01-01

    The Automated Requirements Management System, which is being developed to support traceability and documentation of Space Station Freedom requirements, is described. The objectives of requirements management are validation and verification. Other benefits include comprehensive analytical capabilities, commonality and timeliness of requirements information availability across the program, and the reduction of information duplication and overlap.

  17. Clinician use of standardized assessments following a common elements psychotherapy training and consultation program.

    Science.gov (United States)

    Lyon, Aaron R; Dorsey, Shannon; Pullmann, Michael; Silbaugh-Cowdin, Jessica; Berliner, Lucy

    2015-01-01

    Despite increasing emphasis on the implementation of evidence-based treatments in community service settings, little attention has been paid to supporting the use of evidence-based assessment (EBA) methods and processes, a parallel component of evidence-based practice. Standardized assessment (SA) tools represent a key aspect of EBA and are central to data-driven clinical decision making. The current study evaluated the impact of a statewide training and consultation program in a common elements approach to psychotherapy. Practitioner attitudes toward, skill applying, and use of SA tools across four time points (pre-training, post-training, post-consultation, and follow-up) were assessed. Results indicated early increases in positive SA attitudes, with more gradual increases in self-reported SA skill and use. Implications for supporting the sustained use of SA tools are discussed, including the use of measurement feedback systems, reminders, and SA-supportive supervision practices.

  18. Pengenalan Ababil: Program Finite Element Analysis (FEA 3-Dimensi Untuk Struktur Rangka-Batang

    Directory of Open Access Journals (Sweden)

    Sugeng Waluyo

    2011-02-01

    Full Text Available Ababil is an open source computer program working on the basis offinite element method (FEM which is aimed to analyze frame structures. It is mainly designed as a solver without embedded pre-or/and post-processing units. Recently, the solver is compatible only for reading and writing in the Gmsh [1] pre- and post-processing software environment. The FEM kinematics formulation applied here is relied on the Timoshenko Beam Theory (TBT using linear shape function. Finally, the well-known FEM software MSC.Nastranis used to ensure the capability of Ababil in the prediction of frame deformation by means of FEMsimulation

  19. Human Research Program Human Health Countermeasures Element Extravehicular Activity (EVA) Risk Standing Review Panel (SRP)

    Science.gov (United States)

    Norfleet, William; Harris, Bernard

    2009-01-01

    The Extravehicular Activity (EVA) Risk Standing Review Panel (SRP) was favorably impressed by the operational risk management approach taken by the Human Research Program (HRP) Integrated Research Plan (IRP) to address the stated life sciences issues. The life sciences community at the Johnson Space Center (JSC) seems to be focused on operational risk management. This approach is more likely to provide risk managers with the information they need at the time they need it. Concerning the information provided to the SRP by the EVA Physiology, Systems, and Performance Project (EPSP), it is obvious that a great deal of productive activity is under way. Evaluation of this information was hampered by the fact that it often was not organized in a fashion that reflects the "Gaps and Tasks" approach of the overall Human Health Countermeasures (HHC) effort, and that a substantial proportion of the briefing concerned subjects that, while interesting, are not part of the HHC Element (e.g., the pressurized rover presentation). Additionally, no information was provided on several of the tasks or how they related to work underway or already accomplished. This situation left the SRP having to guess at the efforts and relationship to other elements, and made it hard to easily map the EVA Project efforts currently underway, and the data collected thus far, to the gaps and tasks in the IRP. It seems that integration of the EPSP project into the HHC Element could be improved. Along these lines, we were concerned that our SRP was split off from the other participating SRPs at an early stage in the overall agenda for the meeting. In reality, the concerns of EPSP and other projects share much common ground. For example, the commonality of the concerns of the EVA and exercise physiology groups is obvious, both in terms of what reduced exercise capacity can do to EVA capability, and how the exercise performed during an EVA could contribute to an overall exercise countermeasure prescription.

  20. Human Research Program Human Health Countermeasures Element Nutrition Risk Standing Review Panel

    Science.gov (United States)

    Bistrian, Bruce

    2009-01-01

    The Nutrition Risk Standing Review Panel (SRP) reviewed and discussed the specific gaps and tasks for the Human Health Countermeasures (HHC) Element related to nutrition identified in the Human Research Program (HRP) Integrated Research Plan. There was general consensus that the described gaps and proposed tasks were critical to future NASA mission success. The SRP acknowledged the high scientific quality of the work currently being undertaken by the Nutritional Biochemistry group under the direction of Dr. Scott Smith. In review of the entire HRP, four new gaps were identified that complement the Element's existing research activities. Given the limitations of ground-based analogs for many of the unique physiological and metabolic alterations in space, future studies are needed to quantify nutritional factors that change during actual space flight. In addition, future tasks should seek to better evaluate the time course of physiological and metabolic alterations during flight to better predict alterations during longer duration missions. Finally, given the recent data suggesting a potential role for increased inflammatory responses during space flight, the role of inflammation needs to be explored in detail, including the development of potential countermeasures and new ground based analogs, if this possibility is confirmed.

  1. Building an evidence-informed service array: Considering evidence-based programs as well as their practice elements.

    Science.gov (United States)

    Bernstein, Adam; Chorpita, Bruce F; Daleiden, Eric L; Ebesutani, Chad K; Rosenblatt, Abram

    2015-12-01

    This study empirically examined options for building an evidence-informed service array, comparing strategies to maximize the application of evidence-based treatment literature in a clinical service system. The overall goal was to determine the smallest set of treatments that could serve the largest percentage of clients. Solutions to this problem differ depending on how one defines "treatment." Treatments were conceptualized as (a) programs (integrated treatments produced by specific research laboratories or investigators), and (b) collections of their constituent common procedures, referred to as practice elements. Programs listed by 2 separate government-sanctioned registries were selected to illustrate the effects of "program" conceptualizations, and all available clinical trials testing the programs were analyzed. Practice elements were identified from these same studies and from studies of other treatments that met a standard of evidence but had not been organized into programs on these lists. Relevance mapping methodology was used to identify optimal sets of programs and practice elements. Among a large, diverse clinical population, results identified 11%-22% of youths for whom practice elements provide an evidence-informed treatment option whereas no programs meeting the standard of evidence were available on the registries. Results for the practice elements were able to be matched by a hybrid combination: "best" programs, which were then extended by practice elements. These results demonstrated that there are multiple ways to conceptualize treatments when planning a service array, and these options have significant implications regarding who can be served by treatments supported by evidence. (c) 2015 APA, all rights reserved).

  2. Snake River Sockeye Salmon Captive Broodstock Program; Hatchery Element, 1997 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    Kline, Paul A.; Heindel, Jeff A.; Willard, Catherine (Idaho Department of Fish and Game, Boise, ID)

    2003-08-01

    On November 20, 1991, the National Marine Fisheries Service listed Snake River sockeye salmon Oncorhynchus nerka as endangered under the Endangered Species Act of 1973. In 1991, the Idaho Department of Fish and Game, the Shoshone-Bannock Tribes, and the National Marine Fisheries Service initiated efforts to conserve and rebuild populations in Idaho. Initial steps to recover sockeye salmon included the establishment of a captive broodstock program at the Idaho Department of Fish and Game Eagle Fish Hatchery. Sockeye salmon broodstock and culture responsibilities are shared with the National Marine Fisheries Service at two locations adjacent to Puget Sound in Washington State. Activities conducted by the Shoshone-Bannock Tribes and the National Marine Fisheries Service are reported under separate cover. Idaho Department of Fish and Game monitoring and evaluation activities of captive broodstock program fish releases (annual report to the Bonneville Power Administration for the research element of the program) are also reported under separate cover. Captive broodstock program activities conducted between January 1, 1997 and December 31, 1997 are presented in this report. One hundred twenty-six female sockeye salmon from one captive broodstock group were spawned at the Eagle Fish Hatchery in 1997. Successful spawn pairings produced approximately 148,781 eyed-eggs with a cumulative mean survival to eyed-egg rate of 57.3%. Approximately 361,600 sockeye salmon were released to Sawtooth basin waters in 1997. Reintroduction strategies included eyed-eggs (brood year 1997), presmolts (brood year 1996), and prespawn adults for volitional spawning (brood year 1994). Release locations included Redfish Lake, Alturas Lake, and Pettit Lake. During this reporting period, four broodstocks and two unique production groups were in culture at the Eagle Fish Hatchery. Two of the four broodstocks were incorporated into the 1997 spawning design, and one broodstock was terminated following

  3. The NASA/industry Design Analysis Methods for Vibrations (DAMVIBS) program: Boeing Helicopters airframe finite element modeling

    Science.gov (United States)

    Gabel, R.; Lang, P.; Reed, D.

    1993-01-01

    Mathematical models based on the finite element method of structural analysis, as embodied in the NASTRAN computer code, are routinely used by the helicopter industry to calculate airframe static internal loads used for sizing structural members. Historically, less reliance has been placed on the vibration predictions based on these models. Beginning in the early 1980's NASA's Langley Research Center initiated an industry wide program with the objective of engendering the needed trust in vibration predictions using these models and establishing a body of modeling guides which would enable confident future prediction of airframe vibration as part of the regular design process. Emphasis in this paper is placed on the successful modeling of the Army/Boeing CH-47D which showed reasonable correlation with test data. A principal finding indicates that improved dynamic analysis requires greater attention to detail and perhaps a finer mesh, especially the mass distribution, than the usual stress model. Post program modeling efforts show improved correlation placing key modal frequencies in the b/rev range with 4 percent of the test frequencies.

  4. Trace element concentration in wheat grain: results from the Swedish long-term soil fertility experiments and national monitoring program.

    Science.gov (United States)

    Kirchmann, Holger; Mattsson, Lennart; Eriksson, Jan

    2009-10-01

    Concentrations of trace elements in wheat grain sampled between 1967 and 2003 from the Swedish long-term soil fertility experiments were analyzed using ICP-MS. The long-term effect of inorganic and organic fertilization on trace metal concentrations was investigated including the impact of atmospheric deposition and myccorhiza, whereas other factors such as soil conditions, crop cultivar, etc. are not discussed in this paper. Mean values derived from 10 experimental sites were reported. Significantly declining Pb and Cd concentrations in wheat grain could be explained by lower atmospheric deposition. Mean Se contents in all samples were 0.031 mg kg(-1) grain dry weight. No samples had sufficiently high Se concentrations for human (0.05 mg Se kg(-1)) or animal demand (0.1 mg Se kg(-1)). Concentrations of Co in wheat grain were extremely low, 0.002-0.005 mg Co kg(-1) grain dry weight, and far below the minimum levels required by animals, which applied to all fertilizer treatments. A doubling of Mo concentrations in grain since 1975 resulted in Cu/Mo ratios often below one, which may cause molybdenosis in ruminants. The increase in Mo concentrations in crops correlated with the decline in sulfur deposition. Concentrations of Cu and Fe declined in NPK-fertilized wheat as compared to unfertilized or manure-treated wheat. Very low concentrations of Se and Co and low concentrations of Fe and Cu require attention to counteract risks for deficiencies. The main characteristic of the study is that there are few significant changes over time between different fertilizer treatments, but throughout there are low concentrations of most trace elements in all treatments. In general, good agreement between concentrations in wheat from the long-term fertility experiments and the national monitoring program indicate that values are representative.

  5. 40 CFR 80.1354 - What are the reporting requirements for the gasoline benzene program?

    Science.gov (United States)

    2010-07-01

    ... for the gasoline benzene program? 80.1354 Section 80.1354 Protection of Environment ENVIRONMENTAL... Benzene Recordkeeping and Reporting Requirements § 80.1354 What are the reporting requirements for the gasoline benzene program? (a) Beginning with earliest applicable date specified in § 80.1347(a)(2), any...

  6. 30 CFR 948.26 - Required abandoned mine land reclamation program/plan amendments. [Reserved

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Required abandoned mine land reclamation program/plan amendments. 948.26 Section 948.26 Mineral Resources OFFICE OF SURFACE MINING RECLAMATION AND... STATE WEST VIRGINIA § 948.26 Required abandoned mine land reclamation program/plan amendments. ...

  7. 78 FR 40625 - National School Lunch Program: Direct Certification Continuous Improvement Plans Required by the...

    Science.gov (United States)

    2013-07-08

    ... Food and Nutrition Service 7 CFR Parts 245 and 272 RIN 0584-AE10 National School Lunch Program: Direct Certification Continuous Improvement Plans Required by the Healthy, Hunger-Free Kids Act of 2010; Approval of... ``National School Lunch Program: Direct Certification Continuous Improvement Plans Required by the Healthy...

  8. 30 CFR 75.1713-6 - First-aid training program; minimum requirements.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false First-aid training program; minimum... § 75.1713-6 First-aid training program; minimum requirements. (a) All first-aid training programs... course of instruction similar to that outlined in “First Aid, A Bureau of Mines Instruction Manual.” (b...

  9. 75 FR 30106 - Terrorism Risk Insurance Program; Recordkeeping Requirements for Insurers Compensated Under the...

    Science.gov (United States)

    2010-05-28

    ... Terrorism Risk Insurance Program; Recordkeeping Requirements for Insurers Compensated Under the Program... extension approval by the Office of Management and Budget. The Terrorism Risk Insurance Program Office... [email protected] or by mail (if hard copy, preferably an original and two copies) to: Terrorism Risk...

  10. 75 FR 3193 - Application Package and Reporting Requirements for the Veterinary Medicine Loan Repayment Program...

    Science.gov (United States)

    2010-01-20

    ... Veterinary Medicine Loan Repayment Program (VMLRP) AGENCY: National Institute of Food and Agriculture, USDA... Veterinary Medicine Loan Repayment Program (VMLRP). This Notice initiates a 60-day comment period and... requirements for the Veterinary Medicine Loan Repayment Program (VMLRP) as authorized under section 1415A of...

  11. 34 CFR 400.9 - What additional requirements govern the Vocational and Applied Technology Education Programs?

    Science.gov (United States)

    2010-07-01

    ... Applied Technology Education Programs? 400.9 Section 400.9 Education Regulations of the Offices of the... VOCATIONAL AND APPLIED TECHNOLOGY EDUCATION PROGRAMS-GENERAL PROVISIONS § 400.9 What additional requirements govern the Vocational and Applied Technology Education Programs? In addition to the Act, applicable...

  12. 75 FR 20269 - Regulatory Reporting Requirements for the Indian Community Development Block Grant Program

    Science.gov (United States)

    2010-04-19

    ... Community Development Block Grant Program AGENCY: Office of the Assistant Secretary for Public and Indian... Indian Community Development Block Grants (ICDBG) program. First, the rule provides for submission of a... reporting requirements for the Indian Community Development Block Grant (ICDBG) program. The purpose of the...

  13. RET Functions as a Dual-Specificity Kinase that Requires Allosteric Inputs from Juxtamembrane Elements

    Directory of Open Access Journals (Sweden)

    Iván Plaza-Menacho

    2016-12-01

    Full Text Available Receptor tyrosine kinases exhibit a variety of activation mechanisms despite highly homologous catalytic domains. Such diversity arises through coupling of extracellular ligand-binding portions with highly variable intracellular sequences flanking the tyrosine kinase domain and specific patterns of autophosphorylation sites. Here, we show that the juxtamembrane (JM segment enhances RET catalytic domain activity through Y687. This phospho-site is also required by the JM region to rescue an otherwise catalytically deficient RET activation-loop mutant lacking tyrosines. Structure-function analyses identified interactions between the JM hinge, αC helix, and an unconventional activation-loop serine phosphorylation site that engages the HRD motif and promotes phospho-tyrosine conformational accessibility and regulatory spine assembly. We demonstrate that this phospho-S909 arises from an intrinsic RET dual-specificity kinase activity and show that an equivalent serine is required for RET signaling in Drosophila. Our findings reveal dual-specificity and allosteric components for the mechanism of RET activation and signaling with direct implications for drug discovery.

  14. Electrical, Electronic, and Electromechanical (EEE) parts management and control requirements for NASA space flight programs

    Science.gov (United States)

    1989-01-01

    This document establishes electrical, electronic, and electromechanical (EEE) parts management and control requirements for contractors providing and maintaining space flight and mission-essential or critical ground support equipment for NASA space flight programs. Although the text is worded 'the contractor shall,' the requirements are also to be used by NASA Headquarters and field installations for developing program/project parts management and control requirements for in-house and contracted efforts. This document places increased emphasis on parts programs to ensure that reliability and quality are considered through adequate consideration of the selection, control, and application of parts. It is the intent of this document to identify disciplines that can be implemented to obtain reliable parts which meet mission needs. The parts management and control requirements described in this document are to be selectively applied, based on equipment class and mission needs. Individual equipment needs should be evaluated to determine the extent to which each requirement should be implemented on a procurement. Utilization of this document does not preclude the usage of other documents. The entire process of developing and implementing requirements is referred to as 'tailoring' the program for a specific project. Some factors that should be considered in this tailoring process include program phase, equipment category and criticality, equipment complexity, and mission requirements. Parts management and control requirements advocated by this document directly support the concept of 'reliability by design' and are an integral part of system reliability and maintainability. Achieving the required availability and mission success objectives during operation depends on the attention given reliability and maintainability in the design phase. Consequently, it is intended that the requirements described in this document are consistent with those of NASA publications

  15. Snake River Sockeye Salmon Captive Broodstock Program; Hatchery Element, 2004 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    Baker, Dan J.; Heindel, Jeff A.; Redding, Jeremy (Idaho Department of Fish and Game, Boise, ID)

    2006-05-01

    On November 20, 1991, the National Marine Fisheries Service listed Snake River sockeye salmon Oncorhynchus nerka as endangered under the Endangered Species Act of 1973. In 1991, the Idaho Department of Fish and Game, the Shoshone-Bannock Tribes, and the National Marine Fisheries Service initiated efforts to conserve and rebuild populations in Idaho. Initial steps to recover sockeye salmon included the establishment of a captive broodstock program at the Idaho Department of Fish and Game Eagle Fish Hatchery. Sockeye salmon broodstock and culture responsibilities are shared with the National Oceanic and Atmospheric Administration at two locations adjacent to Puget Sound in Washington State. Activities conducted by the Shoshone-Bannock Tribes and the National Oceanic and Atmospheric Administration are reported under separate cover. Idaho Department of Fish and Game monitoring and evaluation activities of captive broodstock program fish releases (annual report to the Bonneville Power Administration for the research element of the program) are also reported separately. Captive broodstock program activities conducted between January 1, 2004 and December 31, 2004 for the hatchery element of the program are presented in this report. In 2004, twenty-seven anadromous sockeye salmon returned to the Sawtooth Valley. Traps on Redfish Lake Creek and the upper Salmon River at the Sawtooth Fish Hatchery intercepted one and four adults, respectively. Additionally, one adult sockeye salmon was collected at the East Fork Salmon River weir, 18 were seined from below the Sawtooth Fish Hatchery weir, one adult sockeye salmon was observed below the Sawtooth Fish Hatchery weir but not captured, and two adult sockeye salmon were observed in Little Redfish Lake but not captured. Fish were captured/collected between July 24 and September 14, 2004. The captured/collected adult sockeye salmon (12 females and 12 males) originated from a variety of release strategies and were transferred to

  16. 45 CFR 2519.800 - What are the evaluation requirements for Higher Education programs?

    Science.gov (United States)

    2010-10-01

    ... (Continued) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE HIGHER EDUCATION INNOVATIVE PROGRAMS FOR COMMUNITY SERVICE Evaluation Requirements § 2519.800 What are the evaluation requirements for Higher Education... 45 Public Welfare 4 2010-10-01 2010-10-01 false What are the evaluation requirements for Higher...

  17. 78 FR 43820 - Medicare Program; Medical Loss Ratio Requirements for the Medicare Advantage and the Medicare...

    Science.gov (United States)

    2013-07-22

    ... Program; Medical Loss Ratio Requirements for the Medicare Advantage and the Medicare Prescription Drug...; Medical Loss Ratio Requirements for the Medicare Advantage and the Medicare Prescription Drug Benefit... page 31310, in the table of contents for part 423 Subpart X--Requirements for a Minimum Medical Loss...

  18. Risk Evaluation and Mitigation Strategies (REMSs): Are They Improving Drug Safety? A Critical Review of REMSs Requiring Elements to Assure Safe Use (ETASU).

    Science.gov (United States)

    Boudes, Pol F

    2017-06-01

    Risk Evaluation and Mitigation Strategies (REMSs) with Elements to Assure Safe Use (ETASU) are requested for drugs with significant safety risks. We reviewed REMS programs issued since 2011 to evaluate their rationales, characteristics, and consistencies, and evaluated their impact on improving drug safety. We conducted a literature search and a survey of relevant websites (FDA, manufacturers, and REMSs). ETASU characteristics were summarized. REMS risks were compared with labeled risks, including black box warnings. Forty-two programs were analyzed. Seven incorporated drugs of the same class. Most drugs (57%) were indicated for an orphan disease. A single risk was mentioned in 24 REMSs, and multiple risks in 18. Embryo-fetal toxicity and abuse or misuse were the most frequent risks. All risks were identified during clinical development but some were hypothetical. Thirty-six drugs had a black box warning. REMS risks and black box risks differed for 11 drugs. A drug with multiple indications could have a REMS for one of them but not for another. Most REMSs required prescriber training and certification, half required dispenser certification and patient enrolment. REMSs were revised multiple times and only three (7%) were discontinued. No data were available to establish whether REMSs were effective in improving drug safety. Some REMSs were deemed inefficient. REMSs with ETASU continue to be implemented but their impact on improving drug safety is still not documented. Hence, one of the main requirements of the FDA Amendments Act of 2007 is not being addressed. In addition, REMSs are complex and their logic is inconsistent; we recommend a thorough re-evaluation of the REMS program.

  19. Home Blood Pressure Telemonitoring: Rationale for Use, Required Elements, and Barriers to Implementation in Canada.

    Science.gov (United States)

    Wood, Peter W; Boulanger, Pierre; Padwal, Raj S

    2017-05-01

    Contemporary hypertension guidelines strongly endorse the use of home blood pressure (BP) monitoring for hypertension diagnosis and management. However, barriers exist that prevent optimal use of home BP measurements. Patients might not follow the recommended home BP measurement protocol, might not take the required number of readings, and/or might report only selected readings to their providers. Providers might not calculate the mean (used for clinical decision-making) and/or incorporate home BP measurements into the medical record. Use of home BP telemonitoring, defined as the process by which home BP readings are securely teletransmitted and summarized within a health care portal or electronic medical record for provider use, might overcome these barriers. Telemonitoring, especially when combined with protocolized case management, leads to statistically significant and clinically important BP reductions, and improvements in overall BP control. Despite evidence supporting its use, home BP telemonitoring is not widely used in Canada. Barriers to adoption can be classified as structural and financial. Although technological advancements have made telemonitoring highly feasible, infrastructure is lacking, and implementation remains a challenge; this is especially true with respect to creating simple and cost-effective systems that are user-friendly and acceptable to patients as well as to providers. Ensuring data security is crucial to successful implementation, as is developing appropriate reimbursement models for providers. If these barriers can be overcome, home BP telemonitoring has the potential to make care provision easier and more convenient for patients and providers, while improving BP control in Canadians with hypertension. Copyright © 2017 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved.

  20. Evaluation of Vitamin and Trace Element Requirements after Sleeve Gastrectomy at Long Term.

    Science.gov (United States)

    Pellitero, Silvia; Martínez, Eva; Puig, Rocío; Leis, Alba; Zavala, Roxanna; Granada, María Luisa; Pastor, Cruz; Moreno, Pau; Tarascó, Jordi; Puig-Domingo, Manel

    2017-07-01

    Nutritional deficiencies are common after bariatric surgery, but data are scarce after sleeve gastrectomy (SG) at long term. We performed a prospective nutritional status evaluation before and at 2 and 5 years after SG in morbid obese patients receiving mulvitamin and mineral supplementation at a Spanish university hospital. One hundred seventy-six patients (49.3 ± 9.1 years and 46.7 ± 7.4 kg/m 2 ) were evaluated; 51 of them were followed during 5 years. Anthropometric, compliance supplementation intake, and micronutrient evaluation were performed. Baseline concentrations were below normal values for 25(OH) vitamin D (73%), folic acid (16.5%), cobalamin (6.9%), pyridoxine (12%), thiamine (3.4%), and copper (0.5%). Anemia was found in 23%. In 49% of the subjects, at least one micronutrient deficiency was found at 2 years after SG. Vitamin D deficiency persisted at 2 and 5 years higher than 30% of patients. Frequencies of deficiencies for folic acid, B12, B6, and B1 vitamins decreased significantly after 2 years with normalization at 5 years. Copper deficiency increased between 1 and 2 years and it persisted at 5 years after SG. Vitamin supplementation compliance decreased progressively from the first year after surgery (94.8 to 81% at 2 years and to 53% 5 years after surgery). Vitamin D deficiency is the most prevalent long-term nutritional deficiency after SG. About half of patients show some micronutrient deficiency at medium long term, despite supplementation. A proactive follow-up is required to ensure a personalized and adequate supplementation in all surgically treated obese patients including those in which SG has been performed.

  1. 41 CFR 60-2.17 - Additional required elements of affirmative action programs.

    Science.gov (United States)

    2010-07-01

    ... ethnicity-based disparities; (4) Selection, recruitment, referral, and other personnel procedures to determine whether they result in disparities in the employment or advancement of minorities or women; and (5... than following the same procedures which have previously produced inadequate results. Furthermore, a...

  2. Human Research Program Human Health Countermeasures Element Sensorimotor Risk Standing Review Panel (SRP) Final Report

    Science.gov (United States)

    Peterson, Barry

    2009-01-01

    The Sensorimotor Risk Standing Review Panel (SRP) met at the NASA Johnson Space Center on October 4-6, 2009 to discuss the areas of future research targeted by the Human Health Countermeasures (HHC) Element of the Human Research Program (HRP). Using evidence-based knowledge as a background for risks, NASA had identified gaps in knowledge to address those risks. Ongoing and proposed tasks were presented to address the gaps. The charge to the Sensorimotor Risk SRP was to review the gaps, evaluate whether the tasks addressed these gaps and to make recommendations to NASA s HRP Science Management Office regarding the SRP's review. The SRP was requested to evaluate the practicality of the proposed efforts in light of the realistic demands placed on the HRP. In short, all tasks presented in the Integrated Research Plan (IRP) should address specific risks related to the challenges faced by the astronauts as a result of prolonged exposure to microgravity. All tasks proposed to fill the gaps in knowledge should provide applied, translational data necessary to address the specific risks. Several presentations were made to the SRP during the site visit and the SRP spent sufficient time to address the panel charge, either as a group or in separate sessions. The SRP made a final debriefing to the HRP Program Scientist. Taking the evidence and the risk as givens, the SRP reached the following conclusions: 1) the panel is very supportive of and endorses the present activities of the Sensorimotor Risk; and the panel is likewise supportive of the gaps and associated tasks in the IRP; 2) overall, the tasks addressed the gaps in the IRP; 3) there were some gaps and tasks that merit further enhancement and some new gaps/tasks that the SRP recommends.

  3. Viral Hepatitis Strategic Information to Achieve Elimination by 2030: Key Elements for HIV Program Managers

    Science.gov (United States)

    Low-Beer, Daniel; Bergeri, Isabel; Hess, Sarah; Garcia-Calleja, Jesus Maria; Hayashi, Chika; Mozalevskis, Antons; Rinder Stengaard, Annemarie; Sabin, Keith; Harmanci, Hande; Bulterys, Marc

    2017-01-01

    Evidence documenting the global burden of disease from viral hepatitis was essential for the World Health Assembly to endorse the first Global Health Sector Strategy (GHSS) on viral hepatitis in May 2016. The GHSS on viral hepatitis proposes to eliminate viral hepatitis as a public health threat by 2030. The GHSS on viral hepatitis is in line with targets for HIV infection and tuberculosis as part of the Sustainable Development Goals. As coordination between hepatitis and HIV programs aims to optimize the use of resources, guidance is also needed to align the strategic information components of the 2 programs. The World Health Organization monitoring and evaluation framework for viral hepatitis B and C follows an approach similar to the one of HIV, including components on the following: (1) context (prevalence of infection), (2) input, (3) output and outcome, including the cascade of prevention and treatment, and (4) impact (incidence and mortality). Data systems that are needed to inform this framework include (1) surveillance for acute hepatitis, chronic infections, and sequelae and (2) program data documenting prevention and treatment, which for the latter includes a database of patients. Overall, the commonalities between HIV and hepatitis at the strategic, policy, technical, and implementation levels justify coordination, strategic linkage, or integration, depending on the type of HIV and viral hepatitis epidemics. Strategic information is a critical area of this alignment under the principle of what gets measured gets done. It is facilitated because the monitoring and evaluation frameworks for HIV and viral hepatitis were constructed using a similar approach. However, for areas where elimination of viral hepatitis requires data that cannot be collected through the HIV program, collaborations are needed with immunization, communicable disease control, tuberculosis, and hepatology centers to ensure collection of information for the remaining indicators. PMID

  4. Thirty-Two Nodes Hexahedronal Element Subroutine for Multi-Purpose Program MEF.

    Science.gov (United States)

    1986-09-01

    diciplines . A cubic, thirty-two node, three dimensional * isoiparametric element was developed. With such an element very complex structures could be solved...library of one, two, and three-dimensional elements for the solution of problems from a wide variety of diciplines . A cubic, thirty-two node, three...Problem Definition (data base): ............................ 8 2. Element Computations: ................................... 8 3. Assem bly Operations

  5. Workshop on Program for Elimination of Requirements Marginal to Safety: Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    Dey, M. [Nuclear Regulatory Commission, Washington, DC (United States). Div. of Safety Issue Resolution; Arsenault, F.; Patterson, M.; Gaal, M. [SCIENTECH, Inc., Rockville, MD (United States)

    1993-09-01

    These are the proceedings of the Public Workshop on the US Nuclear Regulatory Commission`s Program for Elimination of Requirements Marginal to Safety. The workshop was held at the Holiday Inn, Bethesda, on April 27 and 28, 1993. The purpose of the workshop was to provide an opportunity for public and industry input to the program. The workshop addressed the institutionalization of the program to review regulations with the purpose of eliminating those that are marginal. The objective is to avoid the dilution of safety efforts. One session was devoted to discussion of the framework for a performance-based regulatory approach. In addition, panelists and attendees discussed scope, schedules and status of specific regulatory items: containment leakage testing requirements, fire protection requirements, requirements for environmental qualification of electrical equipment, requests for information under 10CFR50.54(f), requirements for combustible gas control systems, and quality assurance requirements.

  6. Computation of vibration mode elastic-rigid and effective weight coefficients from finite-element computer program output

    Science.gov (United States)

    Levy, R.

    1991-01-01

    Post-processing algorithms are given to compute the vibratory elastic-rigid coupling matrices and the modal contributions to the rigid-body mass matrices and to the effective modal inertias and masses. Recomputation of the elastic-rigid coupling matrices for a change in origin is also described. A computational example is included. The algorithms can all be executed by using standard finite-element program eigenvalue analysis output with no changes to existing code or source programs.

  7. 76 FR 52658 - State Program Requirements; Approval of Application for Program Revision to the National...

    Science.gov (United States)

    2011-08-23

    ... of the transfer of Phase IV of the APDES program, which includes oil and gas, cooling water intakes... discharges (excluding the bio-solids program), timber harvesting, seafood processing facilities and... components include oil and gas, cooling water intakes and dischargers, munitions, and all other remaining...

  8. Quantum biology at the cellular level--elements of the research program.

    Science.gov (United States)

    Bordonaro, Michael; Ogryzko, Vasily

    2013-04-01

    Quantum biology is emerging as a new field at the intersection between fundamental physics and biology, promising novel insights into the nature and origin of biological order. We discuss several elements of QBCL (quantum biology at cellular level) - a research program designed to extend the reach of quantum concepts to higher than molecular levels of biological organization. We propose a new general way to address the issue of environmentally induced decoherence and macroscopic superpositions in biological systems, emphasizing the 'basis-dependent' nature of these concepts. We introduce the notion of 'formal superposition' and distinguish it from that of Schroedinger's cat (i.e., a superposition of macroscopically distinct states). Whereas the latter notion presents a genuine foundational problem, the former one contradicts neither common sense nor observation, and may be used to describe cellular 'decision-making' and adaptation. We stress that the interpretation of the notion of 'formal superposition' should involve non-classical correlations between molecular events in a cell. Further, we describe how better understanding of the physics of Life can shed new light on the mechanism driving evolutionary adaptation (viz., 'Basis-Dependent Selection', BDS). Experimental tests of BDS and the potential role of synthetic biology in closing the 'evolvability mechanism' loophole are also discussed. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  9. Prediction of settlement by using finite element simulation 2D program at Seksyen 7, Shah Alam

    Science.gov (United States)

    Razak, Zakiah; Mukri, Mazidah; Kasim, Nur Aisyah

    2017-08-01

    Construction on soft ground often involves a number of geotechnical issues especially that related to settlements. Excessive post-construction settlements may they be total or differential have always caused serious problem to all parties in the project. Insufficient knowledge on existing ground conditions due to lacking of a proper site investigation coupled with inadequacy in design especially in the foundation for supporting structure could be the likely reasons for causing this problem and lead to eventual instability of the structure above. In general, a reasonably accurate assessment on the rate of settlement of soil is a very important factor in ensuring the achievement of structurally sound building and/or infrastructural work on soft ground without the development of excessive post-construction settlement. In the current investigation, sensitivity analysis to enhance prediction of settlement is carried out using the PLAXIS Finite Element 2D Program by setting the relevant control parameters. This would allow post-construction settlement be predicted during the pre-construction stage be predicted. It is believed that this is useful in assisting the design engineer in arriving at a satisfactory solution subsequently.

  10. 31 CFR 103.120 - Anti-money laundering program requirements for financial institutions regulated by a Federal...

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Anti-money laundering program... Laundering Programs Anti-Money Laundering Programs § 103.120 Anti-money laundering program requirements for... anti-money laundering program that complies with the requirements of §§ 103.176 and 103.178 and the...

  11. Some Practical Considerations for the Sponsorship of Required Postdoctoral General Dentistry Education Programs.

    Science.gov (United States)

    Reed, Michael J.

    1987-01-01

    One issue that must be addressed in determining sponsorship of required postdoctoral dental education programs is the long-term prediction of the population to be served and the institution's ability to serve it. (MSE)

  12. 76 FR 44306 - Proposed Information Collection; Comment Request; Fisheries Finance Program Requirements

    Science.gov (United States)

    2011-07-25

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF COMMERCE National Oceanic and Atmospheric Administration Proposed Information Collection; Comment Request; Fisheries Finance Program Requirements AGENCY: National Oceanic and Atmospheric Administration (NOAA), Commerce...

  13. 45 CFR 2516.820 - What types of internal evaluation activities are required of programs?

    Science.gov (United States)

    2010-10-01

    ... (Continued) CORPORATION FOR NATIONAL AND COMMUNITY SERVICE SCHOOL-BASED SERVICE-LEARNING PROGRAMS Evaluation... required to: (a) Continuously assess management effectiveness, the quality of services provided, and the...

  14. 40 CFR 80.1164 - What are the attest engagement requirements under the RFS program?

    Science.gov (United States)

    2010-07-01

    ... a finding the obligated party's or exporter's RVO, and any deficit RVO carried over from the... report as a finding the commercial computer program used by the party to track the data required by the...

  15. An Ebox element in the proximal Gata4 promoter is required for Gata4 expression in vivo.

    Directory of Open Access Journals (Sweden)

    Alain Boulende Sab

    Full Text Available GATA4 is an essential transcription factor required for the development and function of multiple tissues, including a major role in gonadogenesis. Despite its crucial role, the molecular mechanisms that regulate Gata4 expression in vivo remain poorly understood. We recently found that the Gata4 gene is expressed as multiple transcripts with distinct 5' origins. These co-expressed alternative transcripts are generated by different non-coding first exons with transcripts E1a and E1b being the most prominent. Moreover, we previously showed that an Ebox element, located in Gata4 5' flanking sequences upstream of exon 1a, is important for the promoter activity of these sequences in cell lines. To confirm the importance of this element in vivo, we generated and characterized Gata4 Ebox knockout mice. Quantitative PCR analyses realized on gonads, heart and liver at three developmental stages (embryonic, pre-pubertal and adult revealed that the Ebox mutation leads to a robust and specific decrease (up to 89% of Gata4 E1a transcript expression in all tissues and stages examined. However, a detailed characterization of the gonads revealed normal morphology and GATA4 protein levels in these mutants. Our qPCR data further indicate that this outcome is most likely due to the presence of Gata4 E1b mRNA, whose expression levels were not decreased by the Ebox mutation. In conclusion, our work clearly confirms the importance of the proximal Ebox element and suggests that adequate GATA4 protein expression is likely protected by a compensation mechanism between Gata4 E1a and E1b transcripts operating at the translational level.

  16. 28 CFR 544.71 - Exceptions to required literacy program participation.

    Science.gov (United States)

    2010-07-01

    ... INSTITUTIONAL MANAGEMENT EDUCATION Literacy Program § 544.71 Exceptions to required literacy program... assessment) to have a documented emotional, mental, or physical individual impediment to learning shall not... by the formal diagnostic assessment. (c) Staff shall document in the inmate's education file the...

  17. 78 FR 66670 - Housing Counseling Program: New Certification Requirements; Extension of Public Comment Period

    Science.gov (United States)

    2013-11-06

    ... URBAN DEVELOPMENT 24 CFR Part 214 Housing Counseling Program: New Certification Requirements; Extension... Housing Counseling Program regulations for the purpose of implementing the Dodd-Frank Wall Street Reform and Consumer Protection Act amendments to the housing counseling statute. This document announces that...

  18. 41 CFR 60-300.44 - Required contents of affirmative action programs.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Required contents of affirmative action programs. 60-300.44 Section 60-300.44 Public Contracts and Property Management Other... participation in career days, youth motivation programs, and related activities in their communities. (6) The...

  19. 41 CFR 60-250.44 - Required contents of affirmative action programs.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Required contents of affirmative action programs. 60-250.44 Section 60-250.44 Public Contracts and Property Management Other... career days, youth motivation programs, and related activities in their communities. (6) The contractor...

  20. 33 CFR Appendix B to Part 273 - Information Requirements for Aquatic Plant Control Program Reports

    Science.gov (United States)

    2010-07-01

    ... Aquatic Plant Control Program Reports B Appendix B to Part 273 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE AQUATIC PLANT CONTROL Pt. 273, App. B Appendix B to Part 273—Information Requirements for Aquatic Plant Control Program Reports 1. Location and brief...

  1. 45 CFR 1356.21 - Foster care maintenance payments program implementation requirements.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false Foster care maintenance payments program... ON CHILDREN, YOUTH AND FAMILIES, FOSTER CARE MAINTENANCE PAYMENTS, ADOPTION ASSISTANCE, AND CHILD AND FAMILY SERVICES REQUIREMENTS APPLICABLE TO TITLE IV-E § 1356.21 Foster care maintenance payments program...

  2. An alternate property tax program requiring a forest management plan and scheduled harvesting

    Science.gov (United States)

    D.F. Dennis; P.E. Sendak

    1991-01-01

    Vermont's Use Value Appraisal property tax program, designed to address problems such as tax inequity and forced development caused by taxing agricultural and forest land based on speculative values, requires a forest management plan and scheduled harvests. A probit analysis of enrollment provides evidence of the program's success in attracting large parcels...

  3. 42 CFR 460.134 - Minimum requirements for quality assessment and performance improvement program.

    Science.gov (United States)

    2010-10-01

    ... well being. (ii) Functional status. (iii) Cognitive ability. (iv) Social/behavioral functioning. (v...) Minimum program requirements. A PACE organization's quality assessment and performance improvement program... applicable to the care of PACE participants. (c) Minimum levels of performance. The PACE organization must...

  4. 40 CFR 74.3 - Relationship to the Acid Rain program requirements.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 16 2010-07-01 2010-07-01 false Relationship to the Acid Rain program requirements. 74.3 Section 74.3 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) SULFUR DIOXIDE OPT-INS Background and Summary § 74.3 Relationship to the Acid Rain...

  5. 77 FR 25024 - Certification of Compliance With Meal Requirements for the National School Lunch Program Under...

    Science.gov (United States)

    2012-04-27

    ... is to provide additional funding for SFAs to implement new meal pattern requirements, thus increasing.... The regulatory framework reflects the reality that a reduction in program payments of any amount is... increased nutritional standards for both programs without imposing unnecessary burdens likely to discourage...

  6. 12 CFR 617.7430 - Are institutions required to participate in state agricultural loan mediation programs?

    Science.gov (United States)

    2010-01-01

    ... state agricultural loan mediation programs? 617.7430 Section 617.7430 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM BORROWER RIGHTS Distressed Loan Restructuring; State Agricultural Loan Mediation Programs § 617.7430 Are institutions required to participate in state agricultural loan mediation...

  7. Creating the finite element models of car seats with passive head restraints to meet the requirements of passive safety

    Directory of Open Access Journals (Sweden)

    D. Yu. Solopov

    2014-01-01

    Full Text Available A problem solution to create the car chairs using modern software complexes (CAE based on the finite elements is capable to increase an efficiency of designing process significantly. Designing process is complicated by the fact that at present there are no available techniques focused on this sort of tasks.This article shows the features to create the final element models (FEM of the car chairs having three levels of complexity. It assesses a passive safety, which is ensured by the developed chair models with passive head restraints according to requirements of UNECE No 25 Regulations, and an accuracy of calculation results compared with those of full-scale experiments.This work is part of the developed technique, which allows effective development of the car chair designs both with passive, and with active head restraints, meeting the requirements of passive safety.By results of calculations and experiments it was established that at assessment by an UNECE No 25 technique the "rough" FEM (the 1st and 2nd levels can be considered as rational (in terms of effort to its creation and task solution and by the errors of results, and it is expedient to use them for preliminary and multiple calculations. Detailed models (the 3rd level provide the greatest accuracy (for accelerations the relative error makes 10%, for movements it is 11%, while in comparison with calculations, the relative error for a model of head restraint only decreases by 5% for accelerations and for 9% for movements.The materials presented in the article are used both in research activities and in training students at the Chair of Wheel Vehicles of the Scientific and Educational Complex "Special Mechanical Engineering" of Bauman Moscow State Technical University.

  8. Human Research Program Human Health Countermeasures Element Bone and Muscle Risk Standing Review Panel (SRP)

    Science.gov (United States)

    Glowacki, Julie; Gregor, Robert

    2009-01-01

    The Bone and Muscle Risk Standing Review Panel (SRP) met at the NASA Johnson Space Center (JSC) on October 4-6, 2009 to discuss the areas of current and future research targeted by the Human Health Countermeasures (HHC) Element of the Human Research Program (HRP). Using evidence-based knowledge as a background for identified risks to astronaut health and performance, NASA had identified gaps in knowledge to address those risks. Ongoing and proposed tasks were presented to address the gaps. The charge to the Bone and Muscle Risk SRP was to review the gaps, evaluate whether the tasks addressed these gaps and to make recommendations to NASA s HRP Science Management Office regarding the Panel's review. The Bone and Muscle Risk SRP consisted of scientists who are experts in muscle, bone, or both and could evaluate the existing evidence with sufficient knowledge of the potential effects of long duration exposure to microgravity. More important, although expertise in basic science is important, the SRP was requested to evaluate the practicality of the proposed efforts in light of the realistic demands placed on the HRP. In short, all tasks presented in the Integrated Research Plan (IRP) should address specific questions related to the challenges faced by the astronauts as a result of prolonged exposure to microgravity. All tasks proposed to fill the gaps in knowledge should provide applied, translational data necessary to answer the specific questions. Several presentations were made to the SRP during the site visit and the SRP spent sufficient time to address the panel charge, either as a group or in separate sessions for the Bone and Muscle Risk subgroups. The SRP made a final debriefing to the HRP Program Scientist, Dr. John B. Charles, on October 6, 2009. Taking the evidence and identified risks as givens, the SRP concluded that 1) integration of information should lead to a more comprehensive approach to identifying the gaps, 2) not all tasks addressed the gaps as

  9. Admission and Graduation Requirements for Special Education Doctoral Programs at 20 Top American Universities

    Science.gov (United States)

    Walker, Gabriela

    2009-01-01

    A quantitative analysis of the admissions and graduation requirements guidelines of the special education doctoral programs at 20 top American universities was conducted. Admission requirements typically include an application fee, previous coursework GPA, previous field experience, GRE scores, TOEFL scores, professional writing sample(s), and…

  10. 78 FR 39163 - Certification of Compliance With Meal Requirements for the National School Lunch Program Under...

    Science.gov (United States)

    2013-07-01

    ... of Compliance with Meal Requirements for the National School Lunch Program under the Healthy, Hunger... Healthy, Hunger-Free Kids Act of 2010 regarding performance-based cash assistance for school food...-0025] RIN 0584-AE15 Certification of Compliance With Meal Requirements for the National School Lunch...

  11. Distilling Common History and Practice Elements to Inform Dissemination: Hanf-Model BPT Programs as an Example

    Science.gov (United States)

    Kaehler, Laura A.; Jacobs, Mary; Jones, Deborah J.

    2016-01-01

    There is a shift in evidence-based practice toward an understanding of the treatment elements that characterize empirically-supported interventions in general and the core components of specific approaches in particular. The evidence-base for Behavioral Parent Training (BPT), the standard of care for early-onset disruptive behavior disorders (Oppositional Defiant Disorder and Conduct Disorder), which frequently co-occur with Attention Deficit Hyperactivity Disorder, is well-established; yet, an ahistorical, program-specific lens tells little regarding how leaders, including Constance Hanf at the University of Oregon, shaped the common practice elements of contemporary evidence-based BPT. Accordingly, this review summarizes the formative work of Hanf, as well as the core elements, evolution, and extensions of her work, represented in Community Parent Education (COPE; Cunningham, Bremner, & Boyle, 1995; Cunningham, Bremner, Secord, & Harrison, 2009), Defiant Children (DC; Barkley 1987; Barkley, 2013), Helping the Noncompliant Child (HNC; Forehand & McMahon, 1981; McMahon & Forehand, 2003), Parent-Child Interaction Therapy (PCIT; Eyberg, & Robinson, 1982; Eyberg, 1988; Eyberg & Funderburk, 2011), and the Incredible Years (IY; Webster-Stratton, 1981; 1982; 2008). Our goal is not to provide an exhaustive review of the evidence-base for the Hanf-Model programs; rather, our intention is to provide a template of sorts from which agencies and clinicians can make informed choices about how and why they are using one program versus another, as well as how to make inform flexible use one program or combination of practice elements across programs, to best meet the needs of child clients and their families. Clinical implications and directions for future work are discussed. PMID:27389606

  12. International Experience with Key Program Elements of IndustrialEnergy Efficiency or Greenhouse Gas Emissions Reduction Target-SettingPrograms

    Energy Technology Data Exchange (ETDEWEB)

    Price, Lynn; Galitsky, Christina; Kramer, Klaas Jan

    2008-02-02

    Target-setting agreements, also known as voluntary ornegotiated agreements, have been used by a number of governments as amechanism for promoting energy efficiency within the industrial sector. Arecent survey of such target-setting agreement programs identified 23energy efficiency or GHG emissions reduction voluntary agreement programsin 18 countries. International best practice related to target-settingagreement programs calls for establishment of a coordinated set ofpolicies that provide strong economic incentives as well as technical andfinancial support to participating industries. The key program elementsof a target-setting program are the target-setting process,identification of energy-saving technologies and measures usingenergy-energy efficiency guidebooks and benchmarking as well as byconducting energy-efficiency audits, development of an energy-savingsaction plan, development and implementation of energy managementprotocols, development of incentives and supporting policies, monitoringprogress toward targets, and program evaluation. This report firstprovides a description of three key target-setting agreement programs andthen describes international experience with the key program elementsthat comprise such programs using information from the three keytarget-setting programs as well as from other international programsrelated to industrial energy efficiency or GHG emissionsreductions.

  13. Constellation Program Human-System Integration Requirements. Revision E, Nov. 19, 2010

    Science.gov (United States)

    Dory, Jonathan

    2010-01-01

    The Human-Systems Integration Requirements (HSIR) in this document drive the design of space vehicles, their systems, and equipment with which humans interface in the Constellation Program (CxP). These requirements ensure that the design of Constellation (Cx) systems is centered on the needs, capabilities, and limitations of the human. The HSIR provides requirements to ensure proper integration of human-to-system interfaces. These requirements apply to all mission phases, including pre-launch, ascent, Earth orbit, trans-lunar flight, lunar orbit, lunar landing, lunar ascent, Earth return, Earth entry, Earth landing, post-landing, and recovery. The Constellation Program must meet NASA's Agency-level human rating requirements, which are intended to ensure crew survival without permanent disability. The HSIR provides a key mechanism for achieving human rating of Constellation systems.

  14. Human Research Program Human Health Countermeasures Element: Evidence Report - Artificial Gravity

    Science.gov (United States)

    Clement, Gilles

    2015-01-01

    The most serious risks of long-duration flight involve radiation, behavioral stresses, and physiological deconditioning. Artificial gravity (AG), by substituting for the missing gravitational cues and loading in space, has the potential to mitigate the last of these risks by preventing the adaptive responses from occurring. The rotation of a Mars-bound spacecraft or an embarked human centrifuge offers significant promise as an effective, efficient multi-system countermeasure against the physiological deconditioning associated with prolonged weightlessness. Virtually all of the identified risks associated with bone loss, muscle weakening, cardiovascular deconditioning, and sensorimotor disturbances might be alleviated by the appropriate application of AG. However, experience with AG in space has been limited and a human-rated centrifuge is currently not available on board the ISS. A complete R&D program aimed at determining the requirements for gravity level, gravity gradient, rotation rate, frequency, and duration of AG exposure is warranted before making a decision for implementing AG in a human spacecraft.

  15. 1988 Underground Storage Tanks; Technical Requirements; Final Rule and Underground Storage Tanks Containing Petroleum-Financial Responsibility Requirements and State Program Approval Objective; Final Rule

    Science.gov (United States)

    EPA's 1988 regulations concerning USTs are contained in 40 CFR Part 280, 40 CFR Part 281 and 40 CFR Parts 282.50-282.105 and divided into three sections: technical requirements, financial responsibility requirements, and state program approval objectives.

  16. SANTOS - a two-dimensional finite element program for the quasistatic, large deformation, inelastic response of solids

    Energy Technology Data Exchange (ETDEWEB)

    Stone, C.M.

    1997-07-01

    SANTOS is a finite element program designed to compute the quasistatic, large deformation, inelastic response of two-dimensional planar or axisymmetric solids. The code is derived from the transient dynamic code PRONTO 2D. The solution strategy used to compute the equilibrium states is based on a self-adaptive dynamic relaxation solution scheme, which is based on explicit central difference pseudo-time integration and artificial mass proportional damping. The element used in SANTOS is a uniform strain 4-node quadrilateral element with an hourglass control scheme to control the spurious deformation modes. Finite strain constitutive models for many common engineering materials are included. A robust master-slave contact algorithm for modeling sliding contact is implemented. An interface for coupling to an external code is also provided. 43 refs., 22 figs.

  17. Providing Feedback, Orientation and Opportunities for Reflection as Key Elements for Successful Mentoring Programs: Reviewing a Program for Future Business Education Teachers

    Directory of Open Access Journals (Sweden)

    Elisabeth Riebenbauer

    2017-12-01

    Full Text Available The introduction to teaching is critical for novice teachers. Near the end of their master’s program, students of Business Education and Development in Austria spend one semester at an assigned school. They are introduced to teaching, while being assisted by peer students, mentoring teachers, and a companion course. Mentors receive special training and preparation in advance, thus contributing to a high quality mentoring program. The program is organized threefold: (1 providing feedback, (2 opportunities for reflection and (3 career orientation. The purpose of this paper is to assess key elements of successful mentoring programs and to question which competences of mentors contribute most to the success of those programs. Between 2012 and 2015, 188 persons (student teachers and their mentors responded to an online survey at the end of their mentoring program. Additionally, data from a study (1,245 questionnaires regarding the student teachers’ perception of their own competence was utilized, allowing for a comparison of student teacher confidence in their abilities before and after the mentoring program. The present results provide insight into the key elements of successful mentoring programs; both from a student teacher’s and mentor’s perspective. During the semester, students showed an increase regarding their self-perception of their professional competences. It was found that students and mentoring teachers valued feedback after each lesson more than feedback in regular meetings. Opportunities for reflection (e.g. exchange with peer students, learning diaries were considered helpful. The mentoring program helped students to decide whether to become a teacher or not.

  18. FIESTA ROC: A new finite element analysis program for solar cell simulation

    Science.gov (United States)

    Clark, Ralph O.

    1991-01-01

    The Finite Element Semiconductor Three-dimensional Analyzer by Ralph O. Clark (FIESTA ROC) is a computational tool for investigating in detail the performance of arbitrary solar cell structures. As its name indicates, it uses the finite element technique to solve the fundamental semiconductor equations in the cell. It may be used for predicting the performance (thereby dictating the design parameters) of a proposed cell or for investigating the limiting factors in an established design.

  19. CUERVO: A finite element computer program for nonlinear scalar transport problems

    Energy Technology Data Exchange (ETDEWEB)

    Sirman, M.B.; Gartling, D.K.

    1995-11-01

    CUERVO is a finite element code that is designed for the solution of multi-dimensional field problems described by a general nonlinear, advection-diffusion equation. The code is also applicable to field problems described by diffusion, Poisson or Laplace equations. The finite element formulation and the associated numerical methods used in CUERVO are outlined here; detailed instructions for use of the code are also presented. Example problems are provided to illustrate the use of the code.

  20. MPSalsa Version 1.5: A Finite Element Computer Program for Reacting Flow Problems: Part 1 - Theoretical Development

    Energy Technology Data Exchange (ETDEWEB)

    Devine, K.D.; Hennigan, G.L.; Hutchinson, S.A.; Moffat, H.K.; Salinger, A.G.; Schmidt, R.C.; Shadid, J.N.; Smith, T.M.

    1999-01-01

    The theoretical background for the finite element computer program, MPSalsa Version 1.5, is presented in detail. MPSalsa is designed to solve laminar or turbulent low Mach number, two- or three-dimensional incompressible and variable density reacting fluid flows on massively parallel computers, using a Petrov-Galerkin finite element formulation. The code has the capability to solve coupled fluid flow (with auxiliary turbulence equations), heat transport, multicomponent species transport, and finite-rate chemical reactions, and to solve coupled multiple Poisson or advection-diffusion-reaction equations. The program employs the CHEMKIN library to provide a rigorous treatment of multicomponent ideal gas kinetics and transport. Chemical reactions occurring in the gas phase and on surfaces are treated by calls to CHEMKIN and SURFACE CHEMK3N, respectively. The code employs unstructured meshes, using the EXODUS II finite element database suite of programs for its input and output files. MPSalsa solves both transient and steady flows by using fully implicit time integration, an inexact Newton method and iterative solvers based on preconditioned Krylov methods as implemented in the Aztec. solver library.

  1. A Distinct, Sequence-Induced Conformation Is Required for Recognition of the Constitutive Decay Element RNA by Roquin.

    Science.gov (United States)

    Codutti, Luca; Leppek, Kathrin; Zálešák, Jan; Windeisen, Volker; Masiewicz, Pawel; Stoecklin, Georg; Carlomagno, Teresa

    2015-08-04

    The constitutive decay element (CDE) of tumor necrosis factor α (TNF-α) mRNA (Tnf) represents the prototype of a class of RNA motifs that mediate rapid degradation of mRNAs encoding regulators of the immune response and development. CDE-type RNAs are hairpin structures featuring a tri-nucleotide loop. The protein Roquin recognizes CDE-type stem loops and recruits the Ccr4-Caf1-Not deadenylase complex to the mRNA, thereby inducing its decay. Stem recognition does not involve nucleotide bases; however, there is a strong stem sequence requirement for functional CDEs. Here, we present the solution structures of the natural Tnf CDE and of a CDE mutant with impaired Roquin binding. We find that the two CDEs adopt unique and distinct structures in both the loop and the stem, which explains the ability of Roquin to recognize stem loops in a sequence-specific manner. Our findings result in a relaxed consensus motif for prediction of new CDE stem loops. Copyright © 2015 Elsevier Ltd. All rights reserved.

  2. Dancing UAVs: Using linear programming to model movement behavior with safety requirements

    OpenAIRE

    Dinh, Hoang Tung; Cruz Torres, Mario Henrique; Holvoet, Tom

    2017-01-01

    In this paper we present the use of linear programming to systematically create control software for choreographed UAVs. This application requires the control of multiple UAVs where each UAV follows a predefined trajectory while simultaneously maintaining safety properties, such as keeping a safe distance between each other and geofencing. Modeling and incorporating safety requirements into the movement behavior of UAVs is the main motivation of our research. First, we describe an approach wh...

  3. Sentinel-3 SAR Altimetry Toolbox - Scientific Exploitation of Operational Missions (SEOM) Program Element

    Science.gov (United States)

    Benveniste, Jérôme; Lucas, Bruno; Dinardo, Salvatore

    2014-05-01

    The prime objective of the SEOM (Scientific Exploitation of Operational Missions) element is to federate, support and expand the large international research community that the ERS, ENVISAT and the Envelope programmes have build up over the last 20 years for the future European operational Earth Observation missions, the Sentinels. Sentinel-3 builds directly on a proven heritage pioneered by ERS-1, ERS-2, Envisat and CryoSat-2, with a dual-frequency (Ku and C band) advanced Synthetic Aperture Radar Altimeter (SRAL) that provides measurements at a resolution of ~300m in SAR mode along track. Sentinel-3 will provide exact measurements of sea-surface height along with accurate topography measurements over sea ice, ice sheets, rivers and lakes. The first of the Sentinel-3 series is planned for launch in early 2015. The current universal altimetry toolbox is BRAT (Basic Radar Altimetry Toolbox) which can read all previous and current altimetry mission's data, but it does not have the capabilities to read the upcoming Sentinel-3 L1 and L2 products. ESA will endeavour to develop and supply this capability to support the users of the future Sentinel-3 SAR Altimetry Mission. BRAT is a collection of tools and tutorial documents designed to facilitate the processing of radar altimetry data. This project started in 2005 from the joint efforts of ESA (European Space Agency) and CNES (Centre National d'Etudes Spatiales, the French Space Agency), and it is freely available at http://earth.esa.int/brat. The tools enable users to interact with the most common altimetry data formats, the BratGUI is the front-end for the powerful command line tools that are part of the BRAT suite. BRAT can also be used in conjunction with Matlab/IDL (via reading routines) or in C/C++/Fortran via a programming API, allowing the user to obtain desired data, bypassing the data-formatting hassle. BRAT can be used simply to visualise data quickly, or to translate the data into other formats such as net

  4. Key Elements of Academic Programs Management Management of Postgraduate Virtual Courses at Universidad EAN

    Directory of Open Access Journals (Sweden)

    Gonzalo Benavides Gallego

    2015-12-01

    Full Text Available Rev.esc.adm.neg The main focus of this research study is the management of postgraduate academic programs offered at Univerdsidad EAN in virtual learning. The management processes applied to all types of organizations involve educational institutions. In such institutions, one of the principal actions of their management is to adminístrate academic programs, even though the focus of this study is postgraduate courses, specially the particular issues found in specialization courses and master degree programs base don virtual methodolgy, in which particular features and differences are described concerning the management of the academic programs offered having a face to face methodology.

  5. THERM3D -- A boundary element computer program for transient heat conduction problems

    Energy Technology Data Exchange (ETDEWEB)

    Ingber, M.S. [New Mexico Univ., Albuquerque, NM (United States). Dept. of Mechanical Engineering

    1994-02-01

    The computer code THERM3D implements the direct boundary element method (BEM) to solve transient heat conduction problems in arbitrary three-dimensional domains. This particular implementation of the BEM avoids performing time-consuming domain integrations by approximating a ``generalized forcing function`` in the interior of the domain with the use of radial basis functions. An approximate particular solution is then constructed, and the original problem is transformed into a sequence of Laplace problems. The code is capable of handling a large variety of boundary conditions including isothermal, specified flux, convection, radiation, and combined convection and radiation conditions. The computer code is benchmarked by comparisons with analytic and finite element results.

  6. 10 CFR 420.17 - Optional elements of State Energy Program plans.

    Science.gov (United States)

    2010-01-01

    ... following: (1) Program activities of public education to promote energy efficiency, renewable energy, and... efficiency measures and renewable energy measures— (i) Which may include loan programs and performance... allow rebates, grants, or other incentives for the purchase of energy efficiency measures and renewable...

  7. Generalization of special features of boundary element method realization in Ukrainian computer-aided programming systems

    OpenAIRE

    Korobanov, Yurii M.; Lishchuk, Ohnieslav M.; Lishchuk, Ivan M.

    2014-01-01

    The generalization of theoretical bases for engineering calculations of ship structures in the Ukrainian computer-aided design systems is performed. The mathematical base of the boundary elements method is set out; the boundary integral equation is presented. The method of fictitious loads is considered as the basis of ship structures calculation realization.

  8. 41 CFR 60-741.44 - Required contents of affirmative action programs.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 1 2010-07-01 2010-07-01 true Required contents of affirmative action programs. 60-741.44 Section 60-741.44 Public Contracts and Property Management Other.... Individuals with disabilities should be made available for participation in career days, youth motivation...

  9. 78 FR 79081 - Medicare and Medicaid Programs; Emergency Preparedness Requirements for Medicare and Medicaid...

    Science.gov (United States)

    2013-12-27

    ... disasters. The SNS program ensures the availability of necessary medicines, antidotes, medical supplies, and... ensure that they adequately plan for both natural and man-made disasters, and coordinate with federal... participants during disasters and emergency situations. We are proposing emergency preparedness requirements...

  10. 75 FR 4271 - Refinement of Income and Rent Determination Requirements in Public and Assisted Housing Programs...

    Science.gov (United States)

    2010-01-27

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT 24 CFR Parts 5 and 92 RIN 2501-AD48 Refinement of Income and Rent Determination..., entitled ``Refinement of Income and Rent Determination Requirements in Public and Assisted Housing Programs...

  11. 40 CFR 105.4 - What are the requirements for the Awards Program?

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 21 2010-07-01 2010-07-01 false What are the requirements for the Awards Program? 105.4 Section 105.4 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED...) Nominees must provide written documentation as evidence to support their outstanding technological...

  12. 47 CFR 15.120 - Program blocking technology requirements for television receivers.

    Science.gov (United States)

    2010-10-01

    ... television receivers. 15.120 Section 15.120 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL RADIO FREQUENCY DEVICES Unintentional Radiators § 15.120 Program blocking technology requirements for television receivers. (a) Effective July 1, 1999, manufacturers of television broadcast receivers as defined in section...

  13. Programming Not Required: Skills and Knowledge for the Digital Library Environment

    Science.gov (United States)

    Howard, Katherine

    2010-01-01

    Education for Library and Information professionals in managing the digital environment has been a key topic for discussion within the LIS environment for some time. However, before designing and implementing a program for digital library education, it is prudent to ensure that the skills and knowledge required to work in this environment are…

  14. The Literacy Requirements of an Account Clerk on the Job and in a Vocational Training Program.

    Science.gov (United States)

    Moe, Alden J.; And Others

    As part of a project that identified the specific literacy skills required in ten occupations, this report provides two levels of instructional information about account clerks. Factual data are presented in Parts I and II for use in decision making by program developers, administrators, teachers, and counselors. These sections note the specific…

  15. The Elements of Effective Program Design: A Two-Level Analysis

    Directory of Open Access Journals (Sweden)

    Michael Howlett

    2014-06-01

    Full Text Available Policy and program design is a major theme of contemporary policy research, aimed at improving the understanding of how the processes, methods and tools of policy-making are employed to better formulate effective policies and pro-grams, and to understand the reasons why such designs are not forthcoming. However while many efforts have been made to evaluate policy design, less work has focused on program designs. This article sets out to fill this gap in knowledge of design practices in policy-making. It outlines the nature of the study of policy design with a particular focus on the nature of programs and the lessons derived from empirical experience regarding the conditions that enhance program effectiveness.

  16. Conforming STOP Violence Against Women Formula Grant Program Regulations to Statutory Change; Definitions and Confidentiality Requirements Applicable to All OVW Grant Programs. Final rule.

    Science.gov (United States)

    2016-11-29

    This rule amends the regulations for the STOP (ServicesTrainingOfficersProsecutors) Violence Against Women Formula Grant Program (STOP Program) and the general provisions governing Office on Violence Against Women (OVW) programs to comply with statutory changes and reduce repetition of statutory language. Also, this rule implements statutory requirements for nondisclosure of confidential or private information relating to all OVW grant programs.

  17. Optimal Recycling of Steel Scrap and Alloying Elements: Input-Output based Linear Programming Method with Its Application to End-of-Life Vehicles in Japan.

    Science.gov (United States)

    Ohno, Hajime; Matsubae, Kazuyo; Nakajima, Kenichi; Kondo, Yasushi; Nakamura, Shinichiro; Fukushima, Yasuhiro; Nagasaka, Tetsuya

    2017-11-21

    Importance of end-of-life vehicles (ELVs) as an urban mine is expected to grow, as more people in developing countries are experiencing increased standards of living, while the automobiles are increasingly made using high-quality materials to meet stricter environmental and safety requirements. While most materials in ELVs, particularly steel, have been recycled at high rates, quality issues have not been adequately addressed due to the complex use of automobile materials, leading to considerable losses of valuable alloying elements. This study highlights the maximal potential of quality-oriented recycling of ELV steel, by exploring the utilization methods of scrap, sorted by parts, to produce electric-arc-furnace-based crude alloy steel with minimal losses of alloying elements. Using linear programming on the case of Japanese economy in 2005, we found that adoption of parts-based scrap sorting could result in the recovery of around 94-98% of the alloying elements occurring in parts scrap (manganese, chromium, nickel, and molybdenum), which may replace 10% of the virgin sources in electric arc furnace-based crude alloy steel production.

  18. Suppression of prolactin expression by cabergoline requires prolactin regulatory element-binding protein (PREB) in GH3 cells.

    Science.gov (United States)

    Zhang, W; Murao, K; Imachi, H; Iwama, H; Chen, K; Fei, Z; Zhang, X; Ishida, T; Tamiya, T

    2010-07-01

    The prolactin regulatory element-binding protein (PREB) is a transcriptional factor that regulates prolactin (PRL) promoter activity in the anterior pituitary. Prolactinomas are the most common pituitary tumors. Administration of cabergoline, a selective dopamine D2-receptor agonist, has become the initial therapy of choice for most patients with prolactinomas. Although activation of the D2 receptor results in the inhibition of PRL synthesis, the details of the underlying mechanisms remain unknown. Samples of ten prolactinomas and ten nonfunctioning pituitary adenomas were analyzed by immunohistochemistry to detect the expression of PREB. The effect of cabergoline on PREB expression was assessed by western blotting and real-time polymerase chain reaction (PCR) analysis. Reporter gene analysis of PRL was employed to examine the role of PREB on cabergoline-induced suppression of PRL transcription. Immunohistochemical analysis revealed strong positive PREB expression in the prolactinoma tissue, but extremely weak or undetected expression in the nonfunctioning pituitary tumor tissue. Western blots probed with a PREB-specific antiserum revealed that the relative abundance of the PREB protein in the GH3 cells decreased in a dose-dependent manner in response to cabergoline treatment, as did the relative abundance of PREB mRNA. Although cabergoline inhibited the activity of the PRL promoter, mutation of PREB-binding site within the promoter abrogated the ability of cabergoline to inhibit the PRL promoter activity. We have demonstrated that PREB is expressed in prolactinomas and that the suppression of PRL expression by cabergoline requires the transcriptional factor PREB. (c) Georg Thieme Verlag KG Stuttgart . New York.

  19. Finite-element three-dimensional ground-water (FE3DGW) flow model - formulation, program listings and users' manual

    Energy Technology Data Exchange (ETDEWEB)

    Gupta, S.K.; Cole, C.R.; Bond, F.W.

    1979-12-01

    The Assessment of Effectiveness of Geologic Isolation Systems (AEGIS) Program is developing and applying the methodology for assessing the far-field, long-term post-closure safety of deep geologic nuclear waste repositories. AEGIS is being performed by Pacific Northwest Laboratory (PNL) under contract with the Office of Nuclear Waste Isolation (OWNI) for the Department of Energy (DOE). One task within AEGIS is the development of methodology for analysis of the consequences (water pathway) from loss of repository containment as defined by various release scenarios. Analysis of the long-term, far-field consequences of release scenarios requires the application of numerical codes which simulate the hydrologic systems, model the transport of released radionuclides through the hydrologic systems to the biosphere, and, where applicable, assess the radiological dose to humans. Hydrologic and transport models are available at several levels of complexity or sophistication. Model selection and use are determined by the quantity and quality of input data. Model development under AEGIS and related programs provides three levels of hydrologic models, two levels of transport models, and one level of dose models (with several separate models). This document consists of the description of the FE3DGW (Finite Element, Three-Dimensional Groundwater) Hydrologic model third level (high complexity) three-dimensional, finite element approach (Galerkin formulation) for saturated groundwater flow.

  20. Continuous Modeling Technique of Fiber Pullout from a Cement Matrix with Different Interface Mechanical Properties Using Finite Element Program

    Directory of Open Access Journals (Sweden)

    Leandro Ferreira Friedrich

    Full Text Available Abstract Fiber-matrix interface performance has a great influence on the mechanical properties of fiber reinforced composite. This influence is mainly presented during fiber pullout from the matrix. As fiber pullout process consists of fiber debonding stage and pullout stage which involve complex contact problem, numerical modeling is a best way to investigate the interface influence. Although many numerical research works have been conducted, practical and effective technique suitable for continuous modeling of fiber pullout process is still scarce. The reason is in that numerical divergence frequently happens, leading to the modeling interruption. By interacting the popular finite element program ANSYS with the MATLAB, we proposed continuous modeling technique and realized modeling of fiber pullout from cement matrix with desired interface mechanical performance. For debonding process, we used interface elements with cohesive surface traction and exponential failure behavior. For pullout process, we switched interface elements to spring elements with variable stiffness, which is related to the interface shear stress as a function of the interface slip displacement. For both processes, the results obtained are very good in comparison with other numerical or analytical models and experimental tests. We suggest using the present technique to model toughening achieved by randomly distributed fibers.

  1. Linking the Elements of Change: Program and Client Responses to Innovation

    Science.gov (United States)

    Simpson, D. Dwayne; Joe, George W.; Rowan-Szal, Grace A.

    2007-01-01

    The process of innovation adoption was investigated using longitudinal records collected from a statewide network of almost 60 treatment programs over a 2-year period. Program-level measures of innovation adoption were defined by averaged counselor ratings of program training needs and readiness, organizational functioning, quality of a workshop training conference, and adoption indicators at follow-up. Findings showed that staff attitudes about training needs and past experiences are predictive of their subsequent ratings of training quality and progress in adopting innovations a year later. Organizational climate (clarity of mission, cohesion, openness to change) also is related to innovation adoption. In programs that lack an open atmosphere for adopting new ideas it was found that counselor trial usage is likely to be attenuated. Most important was evidence that innovation adoption based on training for improving treatment engagement was significantly related to client self-reports of improved treatment participation and rapport recorded several months later. PMID:17433862

  2. Establishing a Competency Field-Based Program of Reading Education: Essential Elements of Administrative Planning.

    Science.gov (United States)

    Blair, Charles W.

    1979-01-01

    Identifies essential aspects of administrative planning that must be considered when moving from a traditional reading preservice education program to a competency, field-based model of instruction. (TJ)

  3. DYCAST: A finite element program for the crash analysis of structures

    Science.gov (United States)

    Pifko, A. B.; Winter, R.; Ogilvie, P.

    1987-01-01

    DYCAST is a nonlinear structural dynamic finite element computer code developed for crash simulation. The element library contains stringers, beams, membrane skin triangles, plate bending triangles and spring elements. Changing stiffnesses in the structure are accounted for by plasticity and very large deflections. Material nonlinearities are accommodated by one of three options: elastic-perfectly plastic, elastic-linear hardening plastic, or elastic-nonlinear hardening plastic of the Ramberg-Osgood type. Geometric nonlinearities are handled in an updated Lagrangian formulation by reforming the structure into its deformed shape after small time increments while accumulating deformations, strains, and forces. The nonlinearities due to combined loadings are maintained, and stiffness variation due to structural failures are computed. Numerical time integrators available are fixed-step central difference, modified Adams, Newmark-beta, and Wilson-theta. The last three have a variable time step capability, which is controlled internally by a solution convergence error measure. Other features include: multiple time-load history tables to subject the structure to time dependent loading; gravity loading; initial pitch, roll, yaw, and translation of the structural model with respect to the global system; a bandwidth optimizer as a pre-processor; and deformed plots and graphics as post-processors.

  4. 40 CFR 80.1352 - What are the pre-compliance reporting requirements for the gasoline benzene program?

    Science.gov (United States)

    2010-07-01

    ... requirements for the gasoline benzene program? 80.1352 Section 80.1352 Protection of Environment ENVIRONMENTAL... Benzene Recordkeeping and Reporting Requirements § 80.1352 What are the pre-compliance reporting requirements for the gasoline benzene program? (a) Except as provided in paragraph (c) of this section, a...

  5. POTHMF: A program for computing potential curves and matrix elements of the coupled adiabatic radial equations for a hydrogen-like atom in a homogeneous magnetic field

    Science.gov (United States)

    Chuluunbaatar, O.; Gusev, A. A.; Gerdt, V. P.; Rostovtsev, V. A.; Vinitsky, S. I.; Abrashkevich, A. G.; Kaschiev, M. S.; Serov, V. V.

    2008-02-01

    , etc.:131 396 Distribution format:tar.gz Programming language:FORTRAN 77 Computer:Intel Xeon EM64T, Alpha 21264A, AMD Athlon MP, Pentium IV Xeon, Opteron 248, Intel Pentium IV Operating system:OC Linux, Unix AIX 5.3, SunOS 5.8, Solaris, Windows XP RAM:Depends on the number of radial differential equations; the number and order of finite elements; the number of radial points. Test run requires 4 MB Classification:2.5 External routines:POTHMF uses some Lapack routines, copies of which are included in the distribution (see README file for details). Nature of problem:In the multi-channel adiabatic approach the Schrödinger equation for a hydrogen-like atom in a homogeneous magnetic field of strength γ ( γ=B/B, B≅2.35×10 T is a dimensionless parameter which determines the field strength B) is reduced by separating the radial coordinate, r, from the angular variables, (θ,φ), and using a basis of the angular oblate spheroidal functions [3] to a system of second-order ordinary differential equations which contain first-derivative coupling terms [4]. The purpose of this program is to calculate potential curves and matrix elements of radial coupling needed for calculating the low-lying bound and scattering states of hydrogen-like atoms in a homogeneous magnetic field of strength 0A. Teukolsky, W.T. Vetterling, B.P. Flannery, Numerical Recipes: The Art of Scientific Computing, Cambridge University Press, Cambridge, 1986. http://www.netlib.org/lapack/. M. Abramovits, I.A. Stegun, Handbook of Mathematical Functions, Dover, New York, 1965. U. Fano, Colloq. Int. C.N.R.S. 273 (1977) 127; A.F. Starace, G.L. Webster, Phys. Rev. A 19 (1979) 1629-1640; C.V. Clark, K.T. Lu, A.F. Starace, in: H.G. Beyer, H. Kleinpoppen (Eds.), Progress in Atomic Spectroscopy, Part C, Plenum, New York, 1984, pp. 247-320; U. Fano, A.R.P. Rau, Atomic Collisions and Spectra, Academic Press, Florida, 1986. M.G. Dimova, M.S. Kaschiev, S.I. Vinitsky, J. Phys. B 38 (2005) 2337-2352; O. Chuluunbaatar, A

  6. Pilot program to assess proposed basic quality assurance requirements in the medical use of byproduct materials

    Energy Technology Data Exchange (ETDEWEB)

    Kaplan, E.; Nelson, K.; Meinhold, C.B. (Brookhaven National Lab., Upton, NY (United States))

    1991-10-01

    In January 1990, the Nuclear Regulatory Commission (NRC) proposed amendments to 10 CFR Part 35 that would require medical licensees using byproduct material to establish and implement a basic quality assurance program. A 60-day real-world trial of the proposed rules was initiated to obtain information beyond that generally found through standard public comment procedures. Volunteers from randomly selected institutions had opportunities to review the details of the proposed regulations and to implement these rules on a daily basis during the trial. The participating institutions were then asked to evaluate the proposed regulations based on their personal experiences. The pilot project sought to determine whether medical institutions could develop written quality assurance programs that would meet the eight performance-based objectives of proposed Section 35.35. In addition, the NRC wanted to learn from these volunteers if they had any recommendations on how the rule could be revised to minimized its cost and to clarify its objectives without decreasing its effectiveness. It was found that licensees could develop acceptable QA programs under a performance-based approach, that most licensee programs did meet the proposed objectives, and that most written QA plans would require consultations with NRC or Agreement State personnel before they would fully meet all objectives of proposed Section 35.35. This report describes the overall pilot program. The methodology used to select and assemble the group of participating licensees is presented. The various workshops and evaluation questionnaires are discussed, and detailed findings are presented. 7 refs.

  7. Use of GRASP, a finite element program, to model faulted gas reservoir of the southern North Sea Basin

    Energy Technology Data Exchange (ETDEWEB)

    Collins, P.A.; Goldwater, M.H.; Taylor, B.A.

    1978-01-01

    This study describes a single-phase, 2-dimensional reservoir simulation program called GRASP (gas reservoir areal simulation program) and its use in modeling gas reservoirs in the southern North Sea. The design of the program is outlined, placing special emphasis on those features which have proved to be of greatest value during its application to various gas fields. These include the ability to describe pressure discontinuities across faults and overlapping gas-bearing strata within the context of a 2-dimensional model. The provision of a network analysis model to describe the surface gathering system allows the program to be used either for history matching or for predicting the future reservoir behavior. In the latter case, facilities are provided which allow the consequences of different operating strategies to be investigated. GRASP has been designed, not as a research tool, but as a practical aid to reservoir analysis. Most published applications of finite element methods have considered only small regular reservoirs. In the present study, particular attention is directed toward the difficulties encountered in designing a program capable of describing large, realistic reservoirs. 14 references.

  8. The Myth of Jointness in Department of Defense Requirements and Major Acquisition Programs

    Science.gov (United States)

    2013-06-01

    for a commercial off-the-shelf solution to meet their FCA program requirement. The Air Force, new into the game and their LCA program still in the...Away’ from Issuing First LCA Solicitation,” Insidedefense.com, December 9, 2005, under “Inside the Air Force,” http://insidedefense.com/Inside-the...Air-Force/Inside-the-Air-Force-12/09/2005/air-force-likely-several-years-away-from-issuing-first- lca - solicitation/menu-id-151.html (accessed February 9

  9. Snake River Sockeye Salmon Captive Broodstock Program : Hatchery Element : Annual Progress Report, 2000.

    Energy Technology Data Exchange (ETDEWEB)

    Kline, Paul A.; Willard, Catherine

    2001-04-01

    On November 20, 1991, the National Marine Fisheries Service listed Snake River sockeye salmon Oncorhynchus nerka as endangered under the Endangered Species Act of 1973. In 1991, the Idaho Department of Fish and Game, the Shoshone-Bannock Tribes, and the National Marine Fisheries Service initiated efforts to conserve and rebuild populations in Idaho. Initial steps to recover sockeye salmon included the establishment of a captive broodstock program at the Idaho Department of Fish and Game Eagle Fish Hatchery. Sockeye salmon broodstock and culture responsibilities are shared with the National Marine Fisheries Service at two locations adjacent to Puget Sound in Washington State. Activities conducted by the Shoshone-Bannock Tribes and the National Marine Fisheries Service are reported under separate cover. Idaho Department of Fish and Game monitoring and evaluation activities of captive broodstock program fish releases are also reported under separate cover. Captive broodstock program activities conducted between January 1, 2000 and December 31, 2000 are presented in this report.

  10. NWTS program criteria for mined geologic disposal of nuclear waste: program objectives, functional requirements, and system performance criteria

    Energy Technology Data Exchange (ETDEWEB)

    None

    1981-04-01

    At the present time, final repository criteria have not been issued by the responsible agencies. This document describes general objectives, requirements, and criteria that the DOE intends to apply in the interim to the National Waste Terminal Storage (NWTS) Program. These objectives, requirements, and criteria have been developed on the basis of DOE's analysis of what is needed to achieve the National objective of safe waste disposal in an environmentally acceptable and economic manner and are expected to be consistent with anticipated regulatory standards. The qualitative statements in this document address the broad issues of public and occupational health and safety, institutional acceptability, engineering feasibility, and economic considerations. A comprehensive set of criteria, general and project specific, of which these are a part, will constitute a portion of the technical basis for preparation and submittal by the DOE of formal documents to support future license applications for nuclear waste repositories.

  11. Examining the minimal required elements of a computer-tailored intervention aimed at dietary fat reduction: Results of a randomized controlled dismantling study

    NARCIS (Netherlands)

    W. Kroeze (Willemieke); A. Oenema (Anke); P.C. Dagnelie (Pieter); J. Brug (Hans)

    2008-01-01

    textabstractThis study investigated the minimally required feedback elements of a computer-tailored dietary fat reduction intervention to be effective in improving fat intake. In all 588 Healthy Dutch adults were randomly allocated to one of four conditions in an randomized controlled trial: (i)

  12. Prepositioned Stocks: DOD has Addressed Required Reporting Elements but Needs to Develop a Department-Wide Policy and Joint Service Approach

    Science.gov (United States)

    2016-04-01

    PREPOSITIONED STOCKS DOD Has Addressed Required Reporting Elements but Needs to Develop a Department-wide Policy...United States Government Accountability Office Highlights of GAO-16-418, a report to congressional committees April 2016 PREPOSITIONED STOCKS ...prepositions stocks --such as combat vehicles and repair parts--at locations around the world to prepare forces quickly for conflicts when needed

  13. The 3'-terminal 55 nucleotides of bovine coronavirus defective interfering RNA harbor cis-acting elements required for both negative- and positive-strand RNA synthesis.

    Directory of Open Access Journals (Sweden)

    Wei-Yu Liao

    Full Text Available The synthesis of the negative-strand [(--strand] complement of the ∼30 kilobase, positive-strand [(+-strand] coronaviral genome is a necessary early step for genome replication. The identification of cis-acting elements required for (--strand RNA synthesis in coronaviruses, however, has been hampered due to insufficiencies in the techniques used to detect the (--strand RNA species. Here, we employed a method of head-to-tail ligation and real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR to detect and quantitate the synthesis of bovine coronavirus (BCoV defective interfering (DI RNA (- strands. Furthermore, using the aforementioned techniques along with Northern blot assay, we specifically defined the cis-acting RNA elements within the 3'-terminal 55 nucleotides (nts which function in the synthesis of (-- or (+-strand BCoV DI RNA. The major findings are as follows: (i nts from -5 to -39 within the 3'-terminal 55 nts are the cis-acting elements responsible for (--strand BCoV DI RNA synthesis, (ii nts from -3 to -34 within the 3'-terminal 55 nts are cis-acting elements required for (+-strand BCoV DI RNA synthesis, and (iii the nucleotide species at the 3'-most position (-1 is important, but not critical, for both (-- and (+-strand BCoV DI RNA synthesis. These results demonstrate that the 3'-terminal 55 nts in BCoV DI RNA harbor cis-acting RNA elements required for both (-- and (+-strand DI RNA synthesis and extend our knowledge on the mechanisms of coronavirus replication. The method of head-to-tail ligation and qRT-PCR employed in the study may also be applied to identify other cis-acting elements required for (--strand RNA synthesis in coronaviruses.

  14. The innovation element of the diploma (b.eng.) programs at DTU

    DEFF Research Database (Denmark)

    Nyborg, Mads; Christiansen, Nynne Budtz

    2016-01-01

    Diploma) and the Technical University of Denmark. The most significant new activity in the programs is the introduction of a common 10 ECTS compulsory course in innovation in the later part of the programs. The idea behind this course is to give students the opportunity to collaborate on interdisciplinary...... real-life projects. This course strengthens not only innovation skills but personal and interpersonal skills as well. In this paper we will discuss the organization of the Innovation Pilot course. In particular we focus on: - Structure of programmes - Organization of the Innovation Pilot course...

  15. Atmospheric deposition levels of chosen elements in the Czech Republic determined in the framework of the International Bryomonitoring Program 1995.

    Science.gov (United States)

    Sucharová, J; Suchara, I

    1998-11-03

    In order to determine the atmospheric loads of 13 elements (Al, As, Cd, Co, Cr, Cu, Fe, Mo, Ni, Pb, S, V, Zn), samples of Pleurozium schreberi (81.1%), Hypnum cupressiforme (11.2%) and Pseudoscleropodium purum (7.7%) bryophytes (mosses) were taken and analysed from an approx. 20 x 20-km grid extending over the entire territory (78,864 km2) of the Czech Republic (abbreviated 'the CZ' in this study). The level of the elements found in the bryophytes reflects the relative atmospheric deposition loads of the elements at the investigated sites. Five hot spots indicating relatively high deposition levels were identified in the CZ. The marginal hot spots are the following: the CZ part of the so-called Black Triangle I territory in northwestern CZ; the CZ part of the Black Triangle II territory in northeastern CZ; and the CZ part of the Sudeten mountains (Jizerské Mts and Giant Mts) and their foothills in northern CZ. Inland hot spots were found in the southwestern industrial part of central Bohemia and in the southern Moravian industrial district. The average element contents in CZ bryophytes were comparable with the respective average values obtained in Germany and Poland. However, the CZ average bryophyte values were higher and lower in comparison to the average Austrian and Slovak values, respectively. The CZ average relative atmospheric deposition loads of the elements were found to be 2-3 times higher than the respective loads in the cleanest parts of Europe (e.g. clean parts of Nordic countries). A comparison of the analytical results obtained repeatedly at 20 identical localities in the CZ showed a significant decrease in the relative deposition loads of all of the investigated elements in 1995 as compared to 1991. This decrease has been caused by the dramatic restriction of the industrial production, mainly that of the metallurgical and chemical industries, in the CZ. Desulphurisation programs and the effective trapping of flying dust particles in CZ power plants

  16. Essential Elements of a Collaborative Mental Health Training Program for Primary Care.

    Science.gov (United States)

    Giles, Lisa L; Martini, D Richard

    2017-10-01

    Mental health integration in primary care is based on creating an environment that encourages collaboration and supports appropriate care for patients and families while offering a full range of services. Training programs for primary care practitioners should include sessions on how to build and maintain such a practice along with information on basic mental health competencies. Copyright © 2017 Elsevier Inc. All rights reserved.

  17. National Waste Terminal Storage Program: critical element management concept. Volume II. Concept description

    Energy Technology Data Exchange (ETDEWEB)

    1977-05-01

    The objective of the CEM Concept is to describe techniques for systematically identifying, evaluating, and influencing those technical, social, economic, political and institutional factors (i.e., events, trends and conditions) that are perceived as being probable uncertainties to the attainment of planned program objectives.

  18. Fractured rock modeling in the National Waste Terminal Storage Program: a review of requirements and status

    Energy Technology Data Exchange (ETDEWEB)

    St. John, C.; Krug, A.; Key, S.; Monsees, J.

    1983-05-01

    Generalized computer codes capable of forming the basis for numerical models of fractured rock masses are being used within the NWTS program. Little additional development of these codes is considered justifiable, except in the area of representation of discrete fractures. On the other hand, model preparation requires definition of medium-specific constitutive descriptions and site characteristics and is therefore legitimately conducted by each of the media-oriented projects within the National Waste Terminal Storage program. However, it is essential that a uniform approach to the role of numerical modeling be adopted, including agreement upon the contribution of modeling to the design and licensing process and the need for, and means of, model qualification for particular purposes. This report discusses the role of numerical modeling, reviews the capabilities of several computer codes that are being used to support design or performance assessment, and proposes a framework for future numerical modeling activities within the NWTS program.

  19. Technology requirements to be addressed by the NASA Lewis Research Center Cryogenic Fluid Management Facility program

    Science.gov (United States)

    Aydelott, J. C.; Rudland, R. S.

    1985-01-01

    The NASA Lewis Research Center is responsible for the planning and execution of a scientific program which will provide advance in space cryogenic fluid management technology. A number of future space missions were identified that require or could benefit from this technology. These fluid management technology needs were prioritized and a shuttle attached reuseable test bed, the cryogenic fluid management facility (CFMF), is being designed to provide the experimental data necessary for the technology development effort.

  20. Using Computerized Mental Health Programs in Alternative Education: Understanding the Requirements of Students and Staff.

    Science.gov (United States)

    Kuosmanen, Tuuli; Fleming, Theresa M; Barry, Margaret M

    2017-04-20

    Computerized cognitive behavioral therapy (cCBT) programs have been shown to be both acceptable and effective with youth. However, their use with more vulnerable youth, such as early school leavers, remains relatively unstudied. This study explored student and staff attitudes toward the use of cCBT in an alternative education setting. Student and staff needs were assessed using the Requirements development approach (Van Velsen, Wentzel, & Van Gemert-Pijnen, 2013). An online staff survey (n = 16) was conducted to provide information on the context of delivery, and stakeholder requirements were further explored in four student workshops (n = 32) and staff group discussions (n = 12). Students' requirements in relation to program look and feel were reflective of issues with literacy and concentration. Activity- rather than text-based programs were considered easier to learn from, whereas attractive design with features such as connecting with others were thought necessary to keep young people engaged. Students wanted to learn practical skills on improving their mental health and well-being, using content that is positive, encouraging, and credible and that can be tailored to individual needs. Anonymity and voluntary participation were considered essential when delivering cCBT in the context of alternative education, as well as additional access from home to ensure timeliness of support. Staff required both flexibility and careful planning and timetabling in order to deliver cCBT in the alternative education setting and to support student engagement. The findings provide novel insight into the needs and preferences of vulnerable youth, with important implications for the implementation of computerized mental health programs in alternative education settings. A better understanding of user needs and preferences is critical for improving the uptake and impact of e-mental health resources.

  1. Snake River Sockeye Salmon Captive Broodstock Program; Research Element, 2002 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    Willard, Catherine; Hebdon, J. Lance; Castillo, Jason (Idaho Department of Fish and Game, Boise, ID)

    2004-06-01

    On November 20, 1991, the National Oceanic Atmospheric Administration listed Snake River sockeye salmon Oncorhynchus nerka as endangered under the Endangered Species Act of 1973. In 1991, the Shoshone-Bannock Tribes and Idaho Department of Fish and Game initiated the Snake River Sockeye Salmon Sawtooth Valley Project to conserve and rebuild populations in Idaho. Restoration efforts are focusing on Redfish, Pettit, and Alturas lakes within the Sawtooth Valley. The first release of hatchery-produced juvenile sockeye salmon from the captive broodstock program occurred in 1994. The first anadromous adult returns from the captive broodstock program were recorded in 1999 when six jacks and one jill were captured at IDFG's Sawtooth Fish Hatchery. In 2002, progeny from the captive broodstock program were released using four strategies: age-0 presmolts were released to Alturas, Pettit, and Redfish lakes in August and to Pettit and Redfish lakes in October, age-1 smolts were released to Redfish Lake Creek in May, eyed-eggs were planted in Pettit Lake in December, and hatchery-produced and anadromous adult sockeye salmon were released to Redfish Lake for volitional spawning in September. Oncorhynchus nerka population monitoring was conducted on Redfish, Alturas, and Pettit lakes using a midwater trawl in September 2002. Age-0, age-1, and age-2 O. nerka were captured in Redfish Lake, and population abundance was estimated at 50,204 fish. Age-0, age-1, age-2, and age-3 kokanee were captured in Alturas Lake, and population abundance was estimated at 24,374 fish. Age-2 and age-3 O. nerka were captured in Pettit Lake, and population abundance was estimated at 18,328 fish. The ultimate goal of the Idaho Department of Fish and Game (IDFG) captive broodstock development and evaluation efforts is to recover sockeye salmon runs in Idaho waters. Recovery is defined as reestablishing sockeye salmon runs and providing for utilization of sockeye salmon and kokanee resources by anglers

  2. Effect of a physical fitness program on physical self-concept and physical fitness elements in primary school students.

    Science.gov (United States)

    Mayorga-Vega, D; Viciana, J; Cocca, A; de Rueda Villén, B

    2012-12-01

    The purpose of this study was to assess the short-term effect of a physical fitness program on physical self-concept and physical fitness elements among primary school students. Spanish boys and girls (N = 75; M age = 11.1 yr., SD = 0.4) were divided into an experimental group and a control group. During physical education classes, the experimental group performed an 8-week program including two circuits of 8 exercises done for 15 to 35 sec. each with 45 to 25 sec. of rest between them. Physical self-concept (Physical Self-Description Questionnaire) and physical fitness (EUROFIT battery tests) were measured at the beginning and at the end of the physical fitness program. The results showed that the improvements in physical fitness were not accompanied by major changes in physical self-concept, even though the physical fitness program seemed to maintain the Experimental group's previous physical appearance, strength, and self-esteem perceptions, all of which statistically significantly decreased in the control group after the intervention.

  3. What are the key elements required for a successful and effective word of mouth tourism marketing campaign? – Case analysis

    OpenAIRE

    Piltonen, Anna

    2016-01-01

    The purpose of this thesis was to further study what are the key elements for successful and effective word of mouth marketing campaign in tourism. The objective was to identify the key elements by analysing a real life case provided for this thesis where a tourism board used word of mouth as part of their marketing campaign to increase awareness of the destination and drive tourism in the destination. The case was analysed with the support of secondary research conducted around the topics of...

  4. Snake River Sockeye Salmon Captive Broodstock Program; Hatchery Element, 1998 Annual Progress Report.

    Energy Technology Data Exchange (ETDEWEB)

    Kline, Paul A.; Heindel, Jeff A.

    1999-12-01

    On November 20, 1991, the National Marine Fisheries Service listed Snake River sockeye salmon as endangered under the Endangered Species Act of 1973. In 1991, the Idaho Department of Fish and Game, the Shoshone-Bannock Tribes, and NMFS initiated efforts to conserve and rebuild populations in Idaho. Captive broodstock program activities conducted between January 1, 1998 and December 31, 1998, are presented in this report.

  5. Ca2+, CREB and Krüppel: A novel KLF7-binding element conserved in mouse and human TRKB promoters is required for CREB-dependent transcription

    OpenAIRE

    Kingsbury, Tami J.; Krueger, Bruce K.

    2007-01-01

    Brain-derived neurotrophic factor (BDNF) signaling through its receptor, trkB, is essential for the proper development and function of the nervous system. Here we identify a novel regulatory element designated TCaRE3 (TRKB Ca2+ Response Element 3) required for CREB-dependent TRKB transcription in neurons. TCaRE3-inactivating mutations abolished both Ca2+- and cAMP-stimulated TRKB expression, despite the presence of upstream CREs. TCaRE3 mutations also reduced basal expression by at least 80%....

  6. 75 FR 60263 - Federal Acquisition Regulation; Offering a Construction Requirement-8(a) Program

    Science.gov (United States)

    2010-09-29

    ...The Civilian Agency Acquisition Council and the Defense Acquisition Regulations Council (Councils) are issuing a final rule amending the Federal Acquisition Regulation (FAR) to revise FAR subpart 19.8, Contracting with the Small Business Administration (The 8(a) Program), to conform to the Small Business Administration (SBA) regulations. The FAR Council did not publish this rule for comment because this change will not have a significant effect beyond the internal operating procedures of the Government and will not have a significant effect on contractors or offerors. Furthermore, this requirement has existed in the Small Business Administration Regulations since January 1, 2009, and the FAR is being updated to conform to these regulations. This revision changes the location for submitting offering letters to SBA for a construction requirement for which a specific offeror is nominated and impacts internal procedures that the contracting officer is now required to follow.

  7. Distilling Common History and Practice Elements to Inform Dissemination: Hanf-Model BPT Programs as an Example.

    Science.gov (United States)

    Kaehler, Laura A; Jacobs, Mary; Jones, Deborah J

    2016-09-01

    There is a shift in evidence-based practice toward an understanding of the treatment elements that characterize empirically supported interventions in general and the core components of specific approaches in particular. The evidence base for behavioral parent training (BPT) and the standard of care for early-onset disruptive behavior disorders (oppositional defiant disorder and conduct disorder), which frequently co-occur with attention deficit hyperactivity disorder, are well established, yet an ahistorical, program-specific lens tells little regarding how leaders, University of Oregon Medical School, shaped the common practice elements of contemporary evidence-based BPT. Accordingly, this review summarizes the formative work of Hanf, as well as the core elements, evolution, and extensions of her work, represented in Community Parent Education (COPE; (Cunningham et al. in J Child Psychol Psychiatry 36:1141-1159, 1995; Cunningham et al. in COPE, the community parent education program: large group community-based workshops for parents of 3- to 18-year-olds, COPE Works, Hamilton, 2009), Defiant Children (DC; (Barkley in Defiant children: a clinician's manual for assessment and parent training, Guilford Press, New York, 1987; Barkley in Defiant children: a clinician's manual for assessment and parent training, Guilford Press, New York, 2013), Helping the Noncompliant Child (HNC; Forehand and McMahon in Helping the noncompliant child: a clinician's guide to parent training, Guilford Press, New York, 1981; McMahon and Forehand in Helping the noncompliant child: family-based treatment for oppositional behavior, 2nd ed., Guilford Press, New York, 2003), Parent-child interaction therapy (PCIT; Eyberg and Robinson in J Clin Child Adolesc Psychol 11:130-137, 1982. doi:10.1080/15374418209533076; Eyberg in Child Fam Behav Ther 10:33-46, 1988; Eyberg and Funderburk in Parent-child interaction therapy protocol, PCIT International, Gainesville, 2011), and the Incredible Years

  8. Snake River Sockeye Salmon Captive Broodstock Program Hatchery Element : Project Progress Report 2007 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    Baker, Dan J.; Heindel, Jeff A.; Green, Daniel G.; Kline, Paul A.

    2008-12-17

    Numbers of Snake River sockeye salmon Oncorhynchus nerka have declined dramatically in recent years. In Idaho, only the lakes of the upper Salmon River (Sawtooth Valley) remain as potential sources of production (Figure 1). Historically, five Sawtooth Valley lakes (Redfish, Alturas, Pettit, Stanley, and Yellowbelly) supported sockeye salmon (Bjornn et al. 1968; Chapman et al. 1990). Currently, only Redfish Lake receives a remnant anadromous run. On April 2, 1990, the National Oceanic and Atmospheric Administration Fisheries Service (NOAA - formerly National Marine Fisheries Service) received a petition from the Shoshone-Bannock Tribes (SBT) to list Snake River sockeye salmon as endangered under the United States Endangered Species Act (ESA) of 1973. On November 20, 1991, NOAA declared Snake River sockeye salmon endangered. In 1991, the SBT, along with the Idaho Department of Fish & Game (IDFG), initiated the Snake River Sockeye Salmon Sawtooth Valley Project (Sawtooth Valley Project) with funding from the Bonneville Power Administration (BPA). The goal of this program is to conserve genetic resources and to rebuild Snake River sockeye salmon populations in Idaho. Coordination of this effort is carried out under the guidance of the Stanley Basin Sockeye Technical Oversight Committee (SBSTOC), a team of biologists representing the agencies involved in the recovery and management of Snake River sockeye salmon. National Oceanic and Atmospheric Administration Fisheries Service ESA Permit Nos. 1120, 1124, and 1481 authorize IDFG to conduct scientific research on listed Snake River sockeye salmon. Initial steps to recover the species involved the establishment of captive broodstocks at the Eagle Fish Hatchery in Idaho and at NOAA facilities in Washington State (for a review, see Flagg 1993; Johnson 1993; Flagg and McAuley 1994; Kline 1994; Johnson and Pravecek 1995; Kline and Younk 1995; Flagg et al. 1996; Johnson and Pravecek 1996; Kline and Lamansky 1997; Pravecek and

  9. The case for including reach as a key element of program theory.

    Science.gov (United States)

    Montague, Steve; Porteous, Nancy L

    2013-02-01

    This paper suggests that there is a need to build reach in the logic models and results frameworks of public health initiatives. A lack of explicit thinking about reach in logic models can lead to problems such as narrow/constricted understanding of impacts chain, favoring of 'narrow and efficient' initiatives over 'wide and engaging' initiatives and biased thinking against equity considerations. An alternative approach described in this paper that explicitly considers reach demonstrates that an explicit description of reach in program theory and results logic depictions can improve equity in health and social systems. Copyright © 2012 Elsevier Ltd. All rights reserved.

  10. Snake River Sockeye Salmon Captive Broodstock Program; Hatchery Element, 1999 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    Baker, Dan J,; Heindel, Jeff A.; Kline, Paul A. (Idaho Department of Fish and Game, Boise, ID)

    2005-08-01

    On November 20, 1991, the National Marine Fisheries Service listed Snake River sockeye salmon Oncorhynchus nerka as endangered under the Endangered Species Act of 1973. In 1991, the Idaho Department of Fish and Game, the Shoshone-Bannock Tribes, and the National Marine Fisheries Service initiated efforts to conserve and rebuild populations in Idaho. Initial steps to recover sockeye salmon included the establishment of a captive broodstock program at the Idaho Department of Fish and Game Eagle Fish Hatchery. Sockeye salmon broodstock and culture responsibilities are shared with the National Marine Fisheries Service at two locations adjacent to Puget Sound in Washington State. Activities conducted by the Shoshone-Bannock Tribes and the National Marine Fisheries Service are reported under separate cover. Idaho Department of Fish and Game monitoring and evaluation activities of captive broodstock program fish releases are also reported under separate cover. Captive broodstock program activities conducted between January 1, 1999 and December 31, 1999 are presented in this report. In 1999, seven anadromous sockeye salmon returned to the Sawtooth Valley and were captured at the adult weir located on the upper Salmon River. Four anadromous adults were incorporated in the captive broodstock program spawning design for year 1999. The remaining three adults were released to Redfish Lake for natural spawning. All seven adults were adipose and left ventral fin-clipped, indicating hatchery origin. One sockeye salmon female from the anadromous group and 81 females from the captive broodstock group were spawned at the Eagle Fish Hatchery in 1999. Spawn pairings produced approximately 63,147 eyed-eggs with egg survival to eyed-stage of development averaging 38.97%. Eyed-eggs (20,311), presmolts (40,271), smolts (9,718), and adults (21) were planted or released into Sawtooth Valley waters in 1999. Supplementation strategies involved releases to Redfish Lake, Redfish Lake Creek

  11. Temporal lineage tracing of Aire-expressing cells reveals a requirement for Aire in their maturation program.

    Science.gov (United States)

    Nishikawa, Yumiko; Nishijima, Hitoshi; Matsumoto, Minoru; Morimoto, Junko; Hirota, Fumiko; Takahashi, Satoru; Luche, Hervé; Fehling, Hans Joerg; Mouri, Yasuhiro; Matsumoto, Mitsuru

    2014-03-15

    Understanding the cellular dynamics of Aire-expressing lineage(s) among medullary thymic epithelial cells (AEL-mTECs) is essential for gaining insight into the roles of Aire in establishment of self-tolerance. In this study, we monitored the maturation program of AEL-mTECs by temporal lineage tracing, in which bacterial artificial chromosome transgenic mice expressing tamoxifen-inducible Cre recombinase under control of the Aire regulatory element were crossed with reporter strains. We estimated that the half-life of AEL-mTECs subsequent to Aire expression was ∼7-8 d, which was much longer than that reported previously, owing to the existence of a post-Aire stage. We found that loss of Aire did not alter the overall lifespan of AEL-mTECs, inconsistent with the previous notion that Aire expression in medullary thymic epithelial cells (mTECs) might result in their apoptosis for efficient cross-presentation of self-antigens expressed by AEL-mTECs. In contrast, Aire was required for the full maturation program of AEL-mTECs, as exemplified by the lack of physiological downregulation of CD80 during the post-Aire stage in Aire-deficient mice, thus accounting for the abnormally increased CD80(high) mTECs seen in such mice. Of interest, increased CD80(high) mTECs in Aire-deficient mice were not mTEC autonomous and were dependent on cross-talk with thymocytes. These results further support the roles of Aire in the differentiation program of AEL-mTECs.

  12. MPSalsa a finite element computer program for reacting flow problems. Part 2 - user`s guide

    Energy Technology Data Exchange (ETDEWEB)

    Salinger, A.; Devine, K.; Hennigan, G.; Moffat, H. [and others

    1996-09-01

    This manual describes the use of MPSalsa, an unstructured finite element (FE) code for solving chemically reacting flow problems on massively parallel computers. MPSalsa has been written to enable the rigorous modeling of the complex geometry and physics found in engineering systems that exhibit coupled fluid flow, heat transfer, mass transfer, and detailed reactions. In addition, considerable effort has been made to ensure that the code makes efficient use of the computational resources of massively parallel (MP), distributed memory architectures in a way that is nearly transparent to the user. The result is the ability to simultaneously model both three-dimensional geometries and flow as well as detailed reaction chemistry in a timely manner on MT computers, an ability we believe to be unique. MPSalsa has been designed to allow the experienced researcher considerable flexibility in modeling a system. Any combination of the momentum equations, energy balance, and an arbitrary number of species mass balances can be solved. The physical and transport properties can be specified as constants, as functions, or taken from the Chemkin library and associated database. Any of the standard set of boundary conditions and source terms can be adapted by writing user functions, for which templates and examples exist.

  13. 40 CFR 80.1334 - What are the requirements for early compliance with the gasoline benzene program?

    Science.gov (United States)

    2010-07-01

    ... compliance with the gasoline benzene program? 80.1334 Section 80.1334 Protection of Environment ENVIRONMENTAL... Benzene Hardship Provisions § 80.1334 What are the requirements for early compliance with the gasoline benzene program? (a)(1) A refinery may comply with the benzene requirements at § 80.1230 for its RFG and...

  14. 45 CFR 309.170 - What statistical and narrative reporting requirements apply to Tribal IV-D programs?

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 2 2010-10-01 2010-10-01 false What statistical and narrative reporting... (IV-D) PROGRAM Statistical and Narrative Reporting Requirements § 309.170 What statistical and narrative reporting requirements apply to Tribal IV-D programs? (a) Tribes and Tribal organizations...

  15. 34 CFR 692.54 - What eligibility requirements must a student satisfy to participate in the SLEAP Program?

    Science.gov (United States)

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false What eligibility requirements must a student satisfy to participate in the SLEAP Program? 692.54 Section 692.54 Education Regulations of the Offices of the Department... General § 692.54 What eligibility requirements must a student satisfy to participate in the SLEAP Program...

  16. Baseline requirements can hinder trades in water quality trading programs: Evidence from the Conestoga watershed.

    Science.gov (United States)

    Ghosh, Gaurav; Ribaudo, Marc; Shortle, James

    2011-08-01

    The U.S. Environmental Protection Agency (USEPA) and the U.S. Department of Agriculture (USDA) are promoting point/nonpoint trading as a way of reducing the costs of meeting water quality goals. Farms can create offsets by implementing management practices such as conservation tillage, nutrient management and buffer strips. To be eligible to sell offsets or credits, farmers must first comply with baseline requirements. USEPA guidance recommends that the baseline for nonpoint sources be management practices that are consistent with the water quality goal. A farmer would not be able to create offsets until the minimum practice standards are met. An alternative baseline is those practices being implemented at the time the trading program starts, or when the farmer enters the program. The selection of the baseline affects the efficiency and equity of the trading program. It has major implications for which farmers benefit from trading, the cost of nonpoint source offsets, and ultimately the number of offsets that nonpoint sources can sell to regulated point sources. We use a simple model of the average profit-maximizing dairy farmer operating in the Conestoga watershed in Pennsylvania to evaluate the implications of baseline requirements on the cost and quantity of offsets that can be produced for sale in a water quality trading market, and which farmers benefit most from trading. Published by Elsevier Ltd.

  17. TORO II: A finite element computer program for nonlinear quasi-static problems in electromagnetics: Part 2, User`s manual

    Energy Technology Data Exchange (ETDEWEB)

    Gartling, D.K.

    1996-05-01

    User instructions are given for the finite element, electromagnetics program, TORO II. The theoretical background and numerical methods used in the program are documented in SAND95-2472. The present document also describes a number of example problems that have been analyzed with the code and provides sample input files for typical simulations. 20 refs., 34 figs., 3 tabs.

  18. Regional Missile Defense: DOD’s 2014 Report Generally Addressed Required Reporting Elements, but Excluded Additional Key Details

    Science.gov (United States)

    2014-12-01

    National Defense Authorization Act PAC-3 Patriot Advanced Capability-3 SM-3 Standard Missile-3 THAAD Terminal High Altitude Area Defense This is a...various ranges. • Terminal High Altitude Area Defense ( THAAD ): a mobile, ground- based missile defense system that includes a fire control and...providing forces and resources to support fielding the BMD systems and the specific BMD elements they operate. The Army operates the PAC-3 and THAAD

  19. The 5'-terminal region of the Aichi virus genome encodes cis-acting replication elements required for positive- and negative-strand RNA synthesis.

    Science.gov (United States)

    Nagashima, Shigeo; Sasaki, Jun; Taniguchi, Koki

    2005-06-01

    Aichi virus is a member of the family Picornaviridae. It has already been shown that three stem-loop structures (SL-A, SL-B, and SL-C, from the 5' end) formed at the 5' end of the genome are critical elements for viral RNA replication. In this study, we further characterized the 5'-terminal cis-acting replication elements. We found that an additional structural element, a pseudoknot structure, is formed through base-pairing interaction between the loop segment of SL-B (nucleotides [nt] 57 to 60) and a sequence downstream of SL-C (nt 112 to 115) and showed that the formation of this pseudoknot is critical for viral RNA replication. Mapping of the 5'-terminal sequence of the Aichi virus genome required for RNA replication using a series of Aichi virus-encephalomyocarditis virus chimera replicons indicated that the 5'-end 115 nucleotides including the pseudoknot structure are the minimum requirement for RNA replication. Using the cell-free translation-replication system, we examined the abilities of viral RNAs with a lethal mutation in the 5'-terminal structural elements to synthesize negative- and positive-strand RNAs. The results showed that the formation of three stem-loops and the pseudoknot structure at the 5' end of the genome is required for negative-strand RNA synthesis. In addition, specific nucleotide sequences in the stem of SL-A or its complementary sequences at the 3' end of the negative-strand were shown to be critical for the initiation of positive-strand RNA synthesis but not for that of negative-strand synthesis. Thus, the 5' end of the Aichi virus genome encodes elements important for not only negative-strand synthesis but also positive-strand synthesis.

  20. The 5′-Terminal Region of the Aichi Virus Genome Encodes cis-Acting Replication Elements Required for Positive- and Negative-Strand RNA Synthesis

    Science.gov (United States)

    Nagashima, Shigeo; Sasaki, Jun; Taniguchi, Koki

    2005-01-01

    Aichi virus is a member of the family Picornaviridae. It has already been shown that three stem-loop structures (SL-A, SL-B, and SL-C, from the 5′ end) formed at the 5′ end of the genome are critical elements for viral RNA replication. In this study, we further characterized the 5′-terminal cis-acting replication elements. We found that an additional structural element, a pseudoknot structure, is formed through base-pairing interaction between the loop segment of SL-B (nucleotides [nt] 57 to 60) and a sequence downstream of SL-C (nt 112 to 115) and showed that the formation of this pseudoknot is critical for viral RNA replication. Mapping of the 5′-terminal sequence of the Aichi virus genome required for RNA replication using a series of Aichi virus-encephalomyocarditis virus chimera replicons indicated that the 5′-end 115 nucleotides including the pseudoknot structure are the minimum requirement for RNA replication. Using the cell-free translation-replication system, we examined the abilities of viral RNAs with a lethal mutation in the 5′-terminal structural elements to synthesize negative- and positive-strand RNAs. The results showed that the formation of three stem-loops and the pseudoknot structure at the 5′ end of the genome is required for negative-strand RNA synthesis. In addition, specific nucleotide sequences in the stem of SL-A or its complementary sequences at the 3′ end of the negative-strand were shown to be critical for the initiation of positive-strand RNA synthesis but not for that of negative-strand synthesis. Thus, the 5′ end of the Aichi virus genome encodes elements important for not only negative-strand synthesis but also positive-strand synthesis. PMID:15890931

  1. Striking a Balance between Program Requirements and GT Principles: Writing a compromised GT proposal

    Directory of Open Access Journals (Sweden)

    Sherry L. Xie, Ph.D. Candidate

    2009-06-01

    Full Text Available Glaser’s term “compromised GT proposal” (2001, p.114 refers to the type of Grounded Theory (GT proposal that is written in order to conform to the requirements of a standardized qualitative research proposal. A GT proposal needs only to supply information on the area of interest, the data source and a statement of method to the effect that the researcher begin to collect, code and analyse the data and let the theory emerge. Thus, the proposal may only occupy “a page or two” (Glaser, 2001, p. 111. Whilst being consistent with the methodology, a GT proposal sometimes has to give way to the format specified by a PhD program or committee even though the format was not defined for a GT proposal and in some areas, conflicts with GT principles; for example, the format may require a literature review. This short paper reports on my experience of writing a compromised GT proposal as a first-time GT researcher. It describes how both Glaser’s advice on writing compromised GT research proposals and the characteristics of the substantive area of the proposed research were used to satisfy program requirements while still maintaining GT fundamentals.

  2. A STUDY OF THE REQUIRED PUBLIC ACCOUNTING PROGRAM IN PUBLIC COMPETITIVE EXAMINATIONS HELD BY CESPE

    Directory of Open Access Journals (Sweden)

    Fátima de Souza Freire

    2012-11-01

    Full Text Available With a view to standardizing the contents offered to future Accounting professionals, the Federal Accounting Council (CFC elaborated the National Proposal for Undergraduate Accountancy Program Contents. Thus, the curriculum that Higher Education Institutions (HEI adopt serves as an ally for students’ professional conquests. Stability and favorable job conditions attract many people to the dispute for a public function, with a growing Braz ilian public competitive examination market. According to the National Association for Protection and Support to Public Competitive Examinations (Anpac, between 2003 and 2009, the number of public servants in the executive power with a higher education degree in Brazil increased by 26%. The aim of this study was to confront the CFC’s suggested knowledge with the contents required during tests applied in public competitive examinations for Accountancy professionals. The intent is to identify what Public Accounting knowledge is demanded from candidates for the public career. Through a documentary research, 561 calls from public competitive examinations exclusively for Accountancy professionals were selected for the study sample. They were classified according to the proposed program contents, the test questions by the Center for Selection and Event Promotion (Cespe, between 2000 and 2009. In conclusion, the most frequent required Public Accounting areas are contents related to Public Equity and Budget. The results demonstrate that the CFC’s suggested content is in line with the knowledge required from candidates for public functions.

  3. A recent assessment of the elemental composition of New Zealand pastures in relation to meeting the dietary requirements of grazing livestock.

    Science.gov (United States)

    Knowles, S O; Grace, N D

    2014-01-01

    An understanding of the benefits and limitations of pasture feeding underpins sustainable grazing systems that produce milk and meat from ruminant livestock. We evaluated the mineral composition of 1,106 pasture samples collected independently from locations across New Zealand from 2001 to 2006. About half were submitted during 2002 and 2003, and 87% came from the North Island. Most herbage was from ryegrass and clover-dominated swards. The concentrations of Ca, Co, Cu, Fe, K, Mg, Mn, Mo, Na, P, S, Se, or Zn were measured by nitric acid digestion followed by inductively coupled plasma optical emission spectroscopy or atomic absorption spectroscopy. Median concentrations for the macro elements were Ca 5.5, K 33, Mg 2.2, Na 2.0, P 4.0, and S 3.6 g/kg DM and for the trace elements were Co 0.10, Cu 8.4, Fe 131, Mn 74, Mo 0.66, Se 0.050, and Zn 43 mg/kg DM. Frequency histograms of concentrations revealed distributions ranging from near-normal to bottom-heavy skew with a long tail of high values. The minerals required for good plant growth were found at adequate concentrations in the majority of pastures. The exception was P; only 74% of pastures contained the recommended 3.5 mg P/kg DM. Results of the pasture survey were compared to the dietary intake requirements of cattle and sheep. For 7 elements, >95% of the pastures contained sufficiently high concentrations to meet the needs of unsupplemented animals. Exceptions were the Se dietary requirement, which was met by only 76% of pastures, the Co requirement of sheep met by only 54% of pastures, and the Cu, Na, and P requirements of cattle met by 25, 78, and 87% of pastures, respectively. Pasture analysis is an essential tool for identifying dietary insufficiency as well as unfavorable mineral balances where interactions could induce a deficiency, such as Cu × Mo and Mg × K. Monitoring of animals' nutritional status is also required to manage complex metabolic disorders related to peripartum flux of Ca and Mg. This

  4. Identification and solution structure of a highly conserved C-terminal domain within ORF1p required for retrotransposition of long interspersed nuclear element-1.

    Science.gov (United States)

    Januszyk, Kurt; Li, Patrick Wai-Lun; Villareal, Valerie; Branciforte, Dan; Wu, Haihong; Xie, Yongming; Feigon, Juli; Loo, Joseph A; Martin, Sandra L; Clubb, Robert T

    2007-08-24

    Long interspersed nuclear element-1 (LINE-1 or L1) retrotransposons comprise a large fraction of the human and mouse genomes. The mobility of these successful elements requires the protein encoded by open reading frame-1 (ORF1p), which binds single-stranded RNA with high affinity and functions as a nucleic acid chaperone. In this report, we have used limited proteolysis, filter binding, and NMR spectroscopy to characterize the global structure of ORF1p and the three-dimensional structure of a highly conserved RNA binding domain. ORF1p contains three structured regions, a coiled-coil domain, a middle domain of unknown function, and a C-terminal domain (CTD). We show that high affinity RNA binding by ORF1p requires the CTD and residues within an amino acid protease-sensitive segment that joins the CTD to the middle domain. Insights in the mechanism of RNA binding were obtained by determining the solution structure of the CTD, which is shown to adopt a novel fold consisting of a three-stranded beta sheet that is packed against three alpha-helices. An RNA binding surface on the CTD has been localized using chemical shift perturbation experiments and is proximal to residues previously shown to be essential for retrotransposition, RNA binding, and chaperone activity. A similar structure and mechanism of RNA binding is expected for all vertebrate long interspersed nuclear element-1 elements, since residues encoding the middle, protease-sensitive segment, and CTD are highly conserved.

  5. The formation, elements of success, and challenges in managing a critical care program: part II.

    Science.gov (United States)

    St Andre, Arthur

    2015-05-01

    Leaders of critical care services require knowledge and skills not typically acquired during their medical education and training. Leaders possess personality characteristics and evolve and adopt behaviors and knowledge in addition to those useful in the care of patients and rounding with an ICU team. Successful leaders have impeccable integrity, possess a service mentality, are decisive, and speak the truth consistently and accurately. Effective leaders are thoughtful listeners, introspective, develop a range of relationships, and nurture others. They understand group psychology, observe, analyze assumptions, decide, and improve the system of care and the performance of their team members. A leader learns to facilely adapt to circumstance, generate new ideas, and be a catalyst of change. Those most successful further their education as a leader and learn when and where to seek mentorship. Leaders understand their organization and its operational complexities. Leaders learn to participate and knowledgeably contribute to the fiscal aspects of income, expense, budget, and contracts from an institutional and department perspective. Clinician compensation must be commensurate with expectations and be written to motivate and make clear duties that are clinical and nonclinical. A leader understands and plans to address the evolving challenges facing healthcare, especially resource constraints, the emotions and requirements of managing the end of life, the complexities of competing demands and motivations, the bureaucracy of healthcare practice, and reimbursement. Responsibilities to manage and evolve must be met with intelligence, sensitivity, and equanimity.

  6. TESMA: Requirements and Design of a Tool for Educational Programs

    Directory of Open Access Journals (Sweden)

    Nicolas Guelfi

    2017-03-01

    Full Text Available Defining and managing teaching programs at universities or other institutions is a complex task for which there is not much support in terms of methods and tools. This task becomes even more critical when the time comes to obtain certifications w.r.t. official standards. In this paper, we present an on-going project called TESMA, whose objective is to provide an open-source tool dedicated to the specification and management (including certification of teaching programs. An in-depth market analysis regarding related tools and conceptual frameworks of the project is presented. This tool has been engineered using a development method called Messir for its requirements elicitation and introduces a domain-specific language dedicated to the teaching domain. This paper presents the current status of this project and the future activities planned.

  7. Snake River Sockeye Salmon Captive Broodstock Program Research Elements : 2007 Annual Project Progess Report.

    Energy Technology Data Exchange (ETDEWEB)

    Peterson, Mike; Plaster, Kurtis; Redfield, Laura; Heindel, Jeff; Kline, Paul

    2008-12-17

    On November 20, 1991, the National Oceanic Atmospheric Administration listed Snake River sockeye salmon Oncorhynchus nerka as endangered under the Endangered Species Act of 1973. In 1991, the Shoshone-Bannock Tribes (SBT) and Idaho Department of Fish and Game (IDFG) initiated the Snake River Sockeye Salmon Captive Broodstock Program to conserve and rebuild populations in Idaho. Restoration efforts are focused on Redfish, Pettit, and Alturas lakes within the Sawtooth Valley. The first release of hatchery-produced adults occurred in 1993. The first release of juvenile sockeye salmon from the captive broodstock program occurred in 1994. In 1999, the first anadromous adult returns from the captive broodstock program were recorded when six jacks and one jill were captured at the IDFG Sawtooth Fish Hatchery. In 2007, progeny from the captive broodstock program were released using four strategies: (1) eyed-eggs were planted in Pettit Lake in November; (2) age-0 presmolts were released to Alturas, Pettit, and Redfish lakes in October; (3) age-1 smolts were released into Redfish Lake Creek and the upper Salmon River in May; and (4) hatchery-produced adult sockeye salmon were released to Redfish Lake for volitional spawning in September. Oncorhynchus nerka population monitoring was conducted on Redfish, Alturas, and Pettit lakes using a midwater trawl in September 2007. Population abundances were estimated at 73,702 fish for Redfish Lake, 124,073 fish for Alturas Lake, and 14,746 fish for Pettit Lake. Angler surveys were conducted from May 26 through August 7, 2007 on Redfish Lake to estimate kokanee harvest. On Redfish Lake, we interviewed 102 anglers and estimated that 56 kokanee were harvested. The calculated kokanee catch rate was 0.03 fish/hour for each kokanee kept. The juvenile out-migrant trap on Redfish Lake Creek was operated from April 14 to June 13, 2007. We estimated that 5,280 natural origin and 14,256 hatchery origin sockeye salmon smolts out-migrated from

  8. An "education for life" requirement to promote lifelong learning in an internal medicine residency program.

    Science.gov (United States)

    Panda, Mukta; Desbiens, Norman A

    2010-12-01

    Lifelong learning is an integral component of practice-based learning and improvement. Physicians need to be lifelong learners to provide timely, efficient, and state-of-the-art patient care in an environment where knowledge, technology, and social requirements are rapidly changing. To assess graduates' self-reported perception of the usefulness of a residency program requirement to submit a narrative report describing their planned educational modalities for their future continued medical learning ("Education for Life" requirement), and to compare the modalities residents intended to use with their reported educational activities. Data was compiled from the Education for Life reports submitted by internal medicine residents at the University of Tennessee College of Medicine Chattanooga from 1998 to 2000, and from a survey sent to the same 27 graduates 2 to 4 years later from 2000 to 2004. Twenty-four surveys (89%) were returned. Of the responding graduates, 58% (14/24) found the Education for Life requirement useful for their future continued medical learning. Graduates intended to keep up with a mean of 3.4 educational modalities, and they reported keeping up with 4.2. In a multivariable analysis, the number of modalities graduates used was significantly associated with the number they had planned to use before graduation (P  =  .04) but not with their career choice of subspecialization. The majority of residents found the Education for Life requirement useful for their future continued medical learning. Graduates, regardless of specialty, reported using more modalities for continuing their medical education than they thought they would as residents. Considering lifelong learning early in training and then requiring residents to identify ways to practice lifelong learning as a requirement for graduation may be dispositive.

  9. Implementation of a damage model in a finite element program for computation of structures under dynamic loading

    Directory of Open Access Journals (Sweden)

    Nasserdine Oudni

    2016-01-01

    Full Text Available This work is a numerical simulation of nonlinear problems of the damage process and fracture of quasi-brittle materials especially concrete. In this study, we model the macroscopic behavior of concrete material, taking into account the phenomenon of damage. J. Mazars model whose principle is based on damage mechanics has been implemented in a finite element program written Fortran 90, it takes into account the dissymmetry of concrete behavior in tension and in compression, this model takes into account the cracking tensile and rupture in compression. It is a model that is commonly used for static and pseudo-static systems, but in this work, it was used in the dynamic case.

  10. Snake River Sockeye Salmon Captive Broodstock Program; Research Element, 2003 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    Willard, Catherine; Plaster, Kurtis; Castillo, Jason (Idaho Department of Fish and Game, Boise, ID)

    2005-01-01

    On November 20, 1991, the National Oceanic Atmospheric Administration listed Snake River sockeye salmon Oncorhynchus nerka as endangered under the Endangered Species Act of 1973. In 1991, the Shoshone-Bannock Tribes (SBT) and Idaho Department of Fish and Game (IDFG) initiated the Snake River Sockeye Salmon Captive Broodstock Program to conserve and rebuild populations in Idaho. Restoration efforts are focused on Redfish, Pettit, and Alturas lakes within the Sawtooth Valley. The first release of hatchery-produced adults occurred in 1993. The first release of juvenile sockeye salmon from the captive broodstock program occurred in 1994. In 1999, the first anadromous adult returns from the captive broodstock program were recorded when six jacks and one jill were captured at the IDFG Sawtooth Fish Hatchery. In 2003, progeny from the captive broodstock program were released using three strategies: eyed-eggs were planted in Pettit and Alturas lakes in November and December, age-0 presmolts were released to Alturas, Pettit, and Redfish lakes in October, and hatchery-produced adult sockeye salmon were released to Redfish Lake for volitional spawning in September. Oncorhynchus nerka population monitoring was conducted on Redfish, Alturas, and Pettit lakes using a midwater trawl in September 2003. Age-0 through age-4 O. nerka were captured in Redfish Lake, and population abundance was estimated at 81,727 fish. Age-0 through age-3 O. nerka were captured in Alturas Lake, and population abundance was estimated at 46,234 fish. Age-0 through age-3 O. nerka were captured in Pettit Lake, and population abundance was estimated at 11,961 fish. Angler surveys were conducted from May 25 through August 7, 2003 on Redfish Lake to estimate kokanee harvest. On Redfish Lake, we interviewed 179 anglers and estimated that 424 kokanee were harvested. The calculated kokanee catch rate was 0.09 fish/hour. The juvenile out-migrant trap on Redfish Lake Creek was operated from April 15 to May 29

  11. Snake River Sockeye Salmon Captive Broodstock Program; Research Element, 2001 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    Hebdon, J. Lance; Castillo, Jason; Willard, Catherine (Idaho Department of Fish and Game, Boise, ID)

    2003-12-01

    On November 20, 1991, the National Marine Fisheries Service listed Snake River sockeye salmon Oncorhynchus nerka as endangered under the Endangered Species Act of 1973. In 1991, the Shoshone-Bannock Tribes and Idaho Department of Fish and Game initiated the Snake River Sockeye Salmon Sawtooth Valley Project to conserve and rebuild populations in Idaho. Restoration efforts are focusing on Redfish, Pettit, and Alturas lakes within the Sawtooth Valley. The first release of hatchery-produced juvenile sockeye salmon from the captive broodstock program occurred in 1994. The first anadromous adult returns from the captive broodstock program were recorded in 1999, when six jacks and one jill were captured at Idaho Department of Fish and Game's Sawtooth Fish Hatchery. In 2001, progeny from the captive broodstock program were released using four strategies: age-0 presmolts were released to all three lakes in October and to Pettit and Alturas lakes in July; age-1 smolts were released to Redfish Lake Creek, and hatchery-produced adult sockeye salmon were released to Redfish Lake for volitional spawning in September along with anadromous adult sockeye salmon that returned to the Sawtooth basin and were not incorporated into the captive broodstock program. Kokanee population monitoring was conducted on Redfish, Alturas, and Pettit lakes using a midwater trawl in September. Only age-0 and age-1 kokanee were captured on Redfish Lake, resulting in a population estimate of 12,980 kokanee. This was the second lowest kokanee abundance estimated since 1990. On Alturas Lake age-0, age-1, and age-2 kokanee were captured, and the kokanee population was estimated at 70,159. This is a mid range kokanee population estimate for Alturas Lake, which has been sampled yearly since 1990. On Pettit Lake only age-1 kokanee were captured, and the kokanee population estimate was 16,931. This estimate is in the midrange of estimates of the kokanee population in Pettit Lake, which has been sampled

  12. The formation, elements of success, and challenges in managing a critical care program: Part I.

    Science.gov (United States)

    St Andre, Arthur

    2015-04-01

    Leaders of critical care programs have significant responsibility to develop and maintain a system of intensive care. At inception, those clinician resources necessary to provide and be available for the expected range of patient illness and injury and throughput are determined. Simultaneously, non-ICU clinical responsibilities and other expectations, such as education of trainees and participation in hospital operations, must be understood. To meet these responsibilities, physicians must be recruited, mentored, and retained. The physician leader may have similar responsibilities for nonphysician practitioners. In concert with other critical care leaders, the service adopts a model of care and assembles an ICU team of physicians, nurses, nonphysician providers, respiratory therapists, and others to provide clinical services. Besides clinician resources, leaders must assure that services such as radiology, pharmacy, the laboratory, and information services are positioned to support the complexities of ICU care. Metrics are developed to report success in meeting process and outcomes goals. Leaders evolve the system of care by reassessing and modifying practice patterns to continually improve safety, efficacy, and efficiency. Major emphasis is placed on the importance of continuity, consistency, and communication by expecting practitioners to adopt similar practices and patterns. Services anticipate and adapt to evolving expectations and resource availability. Effective services will result when skilled practitioners support one another and ascribe to a service philosophy of care.

  13. Detailed requirements document for common software of shuttle program information management system

    Science.gov (United States)

    Everette, J. M.; Bradfield, L. D.; Horton, C. L.

    1975-01-01

    Common software was investigated as a method for minimizing development and maintenance cost of the shuttle program information management system (SPIMS) applications while reducing the time-frame of their development. Those requirements satisfying these criteria are presented along with the stand-alone modules which may be used directly by applications. The SPIMS applications operating on the CYBER 74 computer, are specialized information management systems which use System 2000 as a data base manager. Common software provides the features to support user interactions on a CRT terminal using form input and command response capabilities. These features are available as subroutines to the applications.

  14. Requirements for quality control of analytical data for the Environmental Restoration Program

    Energy Technology Data Exchange (ETDEWEB)

    Engels, J.

    1992-12-01

    The Environmental Restoration (ER) Program was established for the investigation and remediation of inactive US Department of Energy (DOE) sites and facilities that have been declared surplus in terms of their previous uses. The purpose of this document is to Specify ER requirements for quality control (QC) of analytical data. Activities throughout all phases of the investigation may affect the quality of the final data product, thus are subject to control specifications. Laboratory control is emphasized in this document, and field concerns will be addressed in a companion document Energy Systems, in its role of technical coordinator and at the request of DOE-OR, extends the application of these requirements to all participants in ER activities. Because every instance and concern may not be addressed in this document, participants are encouraged to discuss any questions with the ER Quality Assurance (QA) Office, the Analytical Environmental Support Group (AESG), or the Analytical Project Office (APO).

  15. Trace element requirements of anoxygenic phototrophic Fe(II)-oxidizers: what we can learn about early earth evolution and the role of these bacteria in BIF deposition

    Science.gov (United States)

    Kappler, A.; Posth, N. R.; Koehler, I.; Hegler, F.; Wartha, E.; Pecoits, E.; Konhauser, K. O.

    2008-12-01

    Banded Iron Formations (BIFs) are Precambrian sedimentary deposits of alternating iron and silica mineral layers. The mechanism of BIF deposition is still unclear. While younger BIFs (2.3-2-5 Ga and younger) probably were deposited due to chemical or biological Fe(II) oxidation involving O2 as electron acceptor, BIFs that are older than 2.5-2.7 Ga were likely deposited in an O2-poor or even O2-free environment. Two formation processes have been suggested for Fe(III) mineral deposition under anoxic conditions. The first mechanism, photooxidation of Fe(II) via UV light, was recently found to have a negligible contribution to BIF formation. Here we focus on the second anoxic mechanism: the biological oxidation of Fe(II) via anoxygenic Fe(II)-oxidizing photoautotrophs. In the work presented, we determined trace element requirements of anoxygenic phototrophic Fe(II)-oxidizing bacteria (Mo, Co, V) and compared the results to trace element abundance and distribution in BIFs deposited before and after the 2.3-2.5 oxidation event. The trace element abundance in the Archean ocean during the time of BIF deposition is linked to the present redox conditions. Additionally, the trace element requirements of these phototrophic Fe(II)-oxidizing strains, in combination with the information about the abundance of these elements in the Archean ocean, constrain the abundance and activity of phototrophic Fe(II)-oxidizing microbes in these oceans. Therefore, the analysis of trace metal distributions in these formations may offer a new tool for investigating the microbial role in mineral formation and BIF deposition. In this way, these analyses may allow the potential activity of these organisms in Precambrian oceans to be constrained and the atmospheric and ocean water-dissolved concentrations of O2 to be inferred.

  16. The essential skills required by librarians to support medical virtual learning programs

    Science.gov (United States)

    Soleymani, Mohammad Reza; Akbari, Zahra; Mojiri, Shahin

    2016-01-01

    Background: With the recent spread of virtual learning programs in universities, especially in the field of medical sciences, libraries play a crucial role to support these programs. This study aimed at investigating the skills required by librarians to support virtual learning programs in Isfahan University and Isfahan University of Medical Sciences. Methods: This was an applied survey study. The population of the study includes all librarians working in Isfahan University and Isfahan University of Medical Sciences. A sample of 89 librarians was selected by stratified random sampling. Data were collected by a researcher-made questionnaire, the validity of which was confirmed by specialists in the fields of librarianship and information sciences and virtual learning, and its reliability was determined to be 0.92, using Cronbach's Alpha. The questionnaire consisted of 51 items designed to evaluate the librarians' virtual learning skills using Likert scale. Descriptive and inferential statistics were used to analyze the findings. Results: The findings of this study revealed that librarians had low level of skills with respect to the online reference services, and familiarity with virtual learning environment. They also showed low and average level of skills with respect to their general information technology, communication skills, ability to teach electronic information literacy and ability to create access to electronic resources. The results revealed no significant difference between the librarians of the two universities, or between male and female librarians. However, librarians with educational background in librarianship and information sciences were significantly more skillful and competent than their colleagues. Conclusion: Despite the crucial role of libraries in supporting virtual learning programs, the librarians in Isfahan University and Isfahan University of Medical Sciences had low-level skills to play such an important role. Therefore, it is essential

  17. The essential skills required by librarians to support medical virtual learning programs.

    Science.gov (United States)

    Soleymani, Mohammad Reza; Akbari, Zahra; Mojiri, Shahin

    2016-01-01

    Background: With the recent spread of virtual learning programs in universities, especially in the field of medical sciences, libraries play a crucial role to support these programs. This study aimed at investigating the skills required by librarians to support virtual learning programs in Isfahan University and Isfahan University of Medical Sciences. Methods: This was an applied survey study. The population of the study includes all librarians working in Isfahan University and Isfahan University of Medical Sciences. A sample of 89 librarians was selected by stratified random sampling. Data were collected by a researcher-made questionnaire, the validity of which was confirmed by specialists in the fields of librarianship and information sciences and virtual learning, and its reliability was determined to be 0.92, using Cronbach's Alpha. The questionnaire consisted of 51 items designed to evaluate the librarians' virtual learning skills using Likert scale. Descriptive and inferential statistics were used to analyze the findings. Results: The findings of this study revealed that librarians had low level of skills with respect to the online reference services, and familiarity with virtual learning environment. They also showed low and average level of skills with respect to their general information technology, communication skills, ability to teach electronic information literacy and ability to create access to electronic resources. The results revealed no significant difference between the librarians of the two universities, or between male and female librarians. However, librarians with educational background in librarianship and information sciences were significantly more skillful and competent than their colleagues. Conclusion: Despite the crucial role of libraries in supporting virtual learning programs, the librarians in Isfahan University and Isfahan University of Medical Sciences had low-level skills to play such an important role. Therefore, it is essential

  18. Advantages of the iridium permanent modifier in fast programs applied to trace-element analysis of plant samples by electrothermal atomic absorption spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Vassileva, E.; Baeten, H.; Hoenig, M. [Centre for Veterinary and Agrochemical Research (CERVA), Tervuren (Belgium)

    2001-03-01

    The application of a fast program combined with the advantages of the iridium permanent modifier is proposed for trace element analysis of plant samples by electrothermal atomic absorption spectrometry (ETAAS). For two volatile elements (Cd, Pb) and two mid-refractory elements (Cr, Ni) it was demonstrated that coating of the platform or of the tube atomization area with Ir is an efficient means of improving the accuracy and precision of results. A detailed study of interference from individual main matrix components and from composite plant matrices has confirmed the usefulness of the whole approach. The validity of the method has been confirmed by analysis of eight reference plant materials. (orig.)

  19. Critical Elements for Successful Implementation and Adoption of Authentic Scientific Research Programs: Lessons Learned from NASA's Mars Student Imaging Project

    Science.gov (United States)

    Klug Boonstra, S.; Swann, J.; Boonstra, D.; Manfredi, L.; Christensen, P. R.

    2016-12-01

    Recent research identifies the most effective learning as active, engaged learning in which students interact with phenomena, other students, and the teacher/leader to derive meaning and construct understanding of their surroundings. "Similarly, an engaging and effective science education goes well beyond the low-level factual recall that is emphasized in many science classes. It must develop the skills that students need to solve complex problems, work in teams, make and recognize evidence-based arguments, and interpret and communicate complex information" (emphasis added). Authentic science research projects provide active, engaged learning in which students interact with authentic science data in an authentic problem-solving context to derive meaning and construct understanding of the world. In formal (and many informal) settings, the teacher/leader is effectively the gatekeeper who determines the learning experiences in which the students will participate. From our experience of nearly a decade and a half of authentic science programming for 5thgrade through early college students working with NASA Mars data, supporting and enabling the teacher is perhaps the most critical and foundational element for designing a successful authentic research experience. Yet, a major barrier to this type of learning are teacher/leaders who are too often not equipped or who lack confidence to succeed in facilitating authentic research projects. The Mars Student Imaging Project has implemented an iterative process of design, testing, and redesign that has identified and implemented critical teacher/leader-enabling elements that have led to increasingly successful adoptions within formal and informal educational settings - allowing more students to gain the benefits of immersive research experience.

  20. Elements Required for an Efficient NADP-Malic Enzyme Type C4 Photosynthesis1[C][W][OPEN

    Science.gov (United States)

    Wang, Yu; Long, Stephen P.; Zhu, Xin-Guang

    2014-01-01

    C4 photosynthesis has higher light, nitrogen, and water use efficiencies than C3 photosynthesis. Although the basic anatomical, cellular, and biochemical features of C4 photosynthesis are well understood, the quantitative significance of each element of C4 photosynthesis to the high photosynthetic efficiency are not well defined. Here, we addressed this question by developing and using a systems model of C4 photosynthesis, which includes not only the Calvin-Benson cycle, starch synthesis, sucrose synthesis, C4 shuttle, and CO2 leakage, but also photorespiration and metabolite transport between the bundle sheath cells and mesophyll cells. The model effectively simulated the CO2 uptake rates, and the changes of metabolite concentrations under varied CO2 and light levels. Analyses show that triose phosphate transport and CO2 leakage can help maintain a high photosynthetic rate by balancing ATP and NADPH amounts in bundle sheath cells and mesophyll cells. Finally, we used the model to define the optimal enzyme properties and a blueprint for C4 engineering. As such, this model provides a theoretical framework for guiding C4 engineering and studying C4 photosynthesis in general. PMID:24521879

  1. Marine sediments monitoring studies for trace elements with the application of fast temperature programs and solid sampling high resolution continuum source atomic absorption spectrometry

    Science.gov (United States)

    Orani, Anna Maria; Han, Eunmi; Mandjukov, Petko; Vassileva, Emilia

    2015-01-01

    Analytical procedure for the determination of As, Cd, Cu, Ni, Co and Cr in marine sediment samples using high-resolution continuum source graphite furnace atomic absorption spectrometry (HR CS AAS) and direct solid sample analysis has been developed. The application of fast programs in combination with direct solid sampling allows to eliminate the drying and pretreatment steps, however makes impossible the use of liquid standards for calibration. Iridium treated platforms were applied throughout the present study. Calibration technique based on the use of solid certified reference materials (marine sediments) similar to the nature of the analyzed sample and statistics of regression analysis were applied to the real sediment samples. The instrumental parameters were optimized in order to obtain reproducible and interference free analytical signals. The ISO-17025 requirements and Eurachem guidelines were followed in the validation of the proposed analytical procedure. Accordingly, blanks, selectivity, calibration, linearity, working range, trueness, repeatability reproducibility, limits of detection and quantification and expanded uncertainty (k = 2) for all investigated elements were assessed. Two different approaches for the estimation of measurement uncertainty were applied and obtained results compared. The major contributors to the combined uncertainty of the analyte mass fraction were found to be the homogeneity of the samples and the microbalance precision. The influence of sample particle sizes on the total combined uncertainty was also evaluated. Traceability to SI system of units of the obtained by the proposed analytical procedure results was demonstrated. Additionally, validation of the methodology developed was effectuated by the comparison of the obtained results with independent method e.g. ICP-MS with external calibration. The use of solid sampling HR CS AAS for the determination of trace elements in marine sediment matrix gives significant advantages

  2. Finite-element nonlinear transient response computer programs PLATE 1 and CIVM-PLATE 1 for the analysis of panels subjected to impulse or impact loads

    Science.gov (United States)

    Spilker, R. L.; Witmer, E. A.; French, S. E.; Rodal, J. J. A.

    1980-01-01

    Two computer programs are described for predicting the transient large deflection elastic viscoplastic responses of thin single layer, initially flat unstiffened or integrally stiffened, Kirchhoff-Lov ductile metal panels. The PLATE 1 program pertains to structural responses produced by prescribed externally applied transient loading or prescribed initial velocity distributions. The collision imparted velocity method PLATE 1 program concerns structural responses produced by impact of an idealized nondeformable fragment. Finite elements are used to represent the structure in both programs. Strain hardening and strain rate effects of initially isotropic material are considered.

  3. Required Assets for a Nuclear Energy Applied R&D Program

    Energy Technology Data Exchange (ETDEWEB)

    Harold F. McFarlane; Craig L. Jacobson

    2009-03-01

    This report is one of a set of three documents that have collectively identified and recommended research and development capabilities that will be required to advance nuclear energy in the next 20 to 50 years. The first report, Nuclear Energy for the Future: Required Research and Development Capabilities—An Industry Perspective, was produced by Battelle Memorial Institute at the request of the Assistant Secretary of Nuclear Energy. That report, drawn from input by industry, academia, and Department of Energy laboratories, can be found in Appendix 5.1. This Idaho National Laboratory report maps the nuclear-specific capabilities from the Battelle report onto facility requirements, identifying options from the set of national laboratory, university, industry, and international facilities. It also identifies significant gaps in the required facility capabilities. The third document, Executive Recommendations for Nuclear R&D Capabilities, is a letter report containing a set of recommendations made by a team of senior executives representing nuclear vendors, utilities, academia, and the national laboratories (at Battelle’s request). That third report can be found in Appendix 5.2. The three reports should be considered as set in order to have a more complete picture. The basis of this report was drawn from three sources: previous Department of Energy reports, workshops and committee meetings, and expert opinion. The facilities discussed were winnowed from several hundred facilities that had previously been catalogued and several additional facilities that had been overlooked in past exercises. The scope of this report is limited to commercial nuclear energy and those things the federal government, or more specifically the Office of Nuclear Energy, should do to support its expanded deployment in order to increase energy security and reduce carbon emissions. In the context of this report, capabilities mean innovative, well-structured research and development programs

  4. The National Security Education Program and Its Service Requirement: An Exploratory Study of What Areas of Government and for What Duration National Security Education Program Recipients Have Worked

    Science.gov (United States)

    Comp, David J.

    2013-01-01

    The National Security Education Program, established under the National Security Education Act of 1991, has had a post-funding service requirement in the Federal Government for undergraduate scholarship and graduate fellowship recipients since its inception. The service requirement, along with the concern that the National Security Education…

  5. Identification and Analysis of Critical Gaps in Nuclear Fuel Cycle Codes Required by the SINEMA Program

    Energy Technology Data Exchange (ETDEWEB)

    Adrian Miron; Joshua Valentine; John Christenson; Majd Hawwari; Santosh Bhatt; Mary Lou Dunzik-Gougar: Michael Lineberry

    2009-10-01

    The current state of the art in nuclear fuel cycle (NFC) modeling is an eclectic mixture of codes with various levels of applicability, flexibility, and availability. In support of the advanced fuel cycle systems analyses, especially those by the Advanced Fuel Cycle Initiative (AFCI), Unviery of Cincinnati in collaboration with Idaho State University carried out a detailed review of the existing codes describing various aspects of the nuclear fuel cycle and identified the research and development needs required for a comprehensive model of the global nuclear energy infrastructure and the associated nuclear fuel cycles. Relevant information obtained on the NFC codes was compiled into a relational database that allows easy access to various codes' properties. Additionally, the research analyzed the gaps in the NFC computer codes with respect to their potential integration into programs that perform comprehensive NFC analysis.

  6. cAMP response element binding protein is required for differentiation of respiratory epithelium during murine development.

    Directory of Open Access Journals (Sweden)

    A Daniel Bird

    Full Text Available The cAMP response element binding protein 1 (Creb1 transcription factor regulates cellular gene expression in response to elevated levels of intracellular cAMP. Creb1(-/- fetal mice are phenotypically smaller than wildtype littermates, predominantly die in utero and do not survive after birth due to respiratory failure. We have further investigated the respiratory defect of Creb1(-/- fetal mice during development. Lungs of Creb1(-/- fetal mice were pale in colour and smaller than wildtype controls in proportion to their reduced body size. Creb1(-/- lungs also did not mature morphologically beyond E16.5 with little or no expansion of airway luminal spaces, a phenotype also observed with the Creb1(-/- lung on a Crem(-/- genetic background. Creb1 was highly expressed throughout the lung at all stages examined, however activation of Creb1 was detected primarily in distal lung epithelium. Cell differentiation of E17.5 Creb1(-/- lung distal epithelium was analysed by electron microscopy and showed markedly reduced numbers of type-I and type-II alveolar epithelial cells. Furthermore, immunomarkers for specific lineages of proximal epithelium including ciliated, non-ciliated (Clara, and neuroendocrine cells showed delayed onset of expression in the Creb1(-/- lung. Finally, gene expression analyses of the E17.5 Creb1(-/- lung using whole genome microarray and qPCR collectively identified respiratory marker gene profiles and provide potential novel Creb1-regulated genes. Together, these results demonstrate a crucial role for Creb1 activity for the development and differentiation of the conducting and distal lung epithelium.

  7. 78 FR 63990 - HIV/AIDS Bureau; Ryan White HIV/AIDS Program Core Medical Services Waiver; Application Requirements

    Science.gov (United States)

    2013-10-25

    ... the Ryan White HIV/AIDS Treatment Extension Act of 2009 (Ryan White Program or RWHAP), requires that... evidence must include all of the following: a. HIV/AIDS care and treatment services inventories, including... HUMAN SERVICES Health Resources and Services Administration HIV/AIDS Bureau; Ryan White HIV/AIDS Program...

  8. 33 CFR Appendix C to Part 273 - Information Requirements for Aquatic Plant Control Program Environmental Impact Statements

    Science.gov (United States)

    2010-07-01

    ... Aquatic Plant Control Program Environmental Impact Statements C Appendix C to Part 273 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE AQUATIC PLANT CONTROL Pt. 273, App. C Appendix C to Part 273—Information Requirements for Aquatic Plant Control Program...

  9. 34 CFR 350.63 - What are the requirements of a grantee relative to the Client Assistance Program?

    Science.gov (United States)

    2010-07-01

    ... Client Assistance Program? 350.63 Section 350.63 Education Regulations of the Offices of the Department... After an Award? § 350.63 What are the requirements of a grantee relative to the Client Assistance... representatives, of the availability and purposes of the Client Assistance Program (CAP) funded under the Act; and...

  10. 40 CFR 3.2000 - What are the requirements authorized state, tribe, and local programs' reporting systems must meet?

    Science.gov (United States)

    2010-07-01

    ... state, tribe, and local programs' reporting systems must meet? 3.2000 Section 3.2000 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GENERAL CROSS-MEDIA ELECTRONIC REPORTING Electronic Reporting Under EPA-Authorized State, Tribe, and Local Programs § 3.2000 What are the requirements authorized...

  11. Colloquy and workshops: regional implications of the engineering manpower requirements of the National Energy Program

    Energy Technology Data Exchange (ETDEWEB)

    Segool, H. D. [ed.

    1979-05-01

    The crucial interrelationships of engineering manpower, technological innovation, productivity and capital re-formaton were keynoted. Near-term, a study has indicated a much larger New England energy demand-reduction/economic/market potential, with a probably larger engineering manpower requirement, for energy-conservation measures characterized by technological innovation and cost-effective capital services than for alternative energy-supply measures. Federal, regional, and state energy program responsibilities described a wide-ranging panorama of activities among many possible energy options which conveyed much endeavor without identifiable engineering manpower demand coefficients. Similarly, engineering manpower assessment data was described as uneven and unfocused to the energy program at the national level, disaggregated data as non-existent at the regional/state levels, although some qualitative inferences were drawn. A separate abstract was prepared for each of the 16 individual presentations for the DOE Energy Data Base (EDB); 14 of these were selected for Energy Abstracts for Policy Analysis (EAPA) and 2 for Energy Research Abstracts (ERA).

  12. Elements of Dynamic Programming,

    Science.gov (United States)

    1981-02-02

    UuJACJCIMOIC 3 IICP- ~I) ovio orpacAb. itiafpe.iclclcoe FiA KOAI14CCTnO CptACTO Y1=- - X,1 , nNAeActmIole so DropylO OTP.ICJb DOC = 0151504 PAGE...again all ressvu .te ara packed intc tranch II;their remaiader/residue at tle fau or tae CiLtn year (and entira period) will ie equal tc 0.04 20. iu...we ccnatruct the sesries of curves fcz fau ..t .a w3 ., aependlnS ca X3 IFig. 12.5). For each of these curves we ,oe kuit wi.th the maximum ordinate

  13. Infrastructures Required for the Expansion of Family Physician Program to Urban Settings in Iran.

    Science.gov (United States)

    Doshmangir, Leila; Bazyar, Mohammad; Doshmangir, Parinaz; Mostafavi, Hakimeh; Takian, Amirhossein

    2017-09-01

    Following the implementation of Family Physician (FP) Program in rural areas and cities with populations under 20000 in 2005, the Iranian Ministry of Health and Medical Education in 2012 decided to implement urban FP in large cities with populations more than 20000. Along with the development and implementation of urban FP in Iran, local websites and newspapers reflected the viewpoints of experts in various levels of health system regarding the various stages of Family Medicine (FM) development (from agenda setting to initial stages of implementation). This study aimed to explore the major infrastructures perceived to be required to achieve desirable implementation of urban FP through analyzing experts' viewpoints reflected in the media and interviews. In a qualitative study, we analyzed the contents of health related national websites as well as transcribed interviews with key informants. Documents were collected from December 2011 to January 2014 and interviews were conducted from February 2014 to June 2015. We used mixed thematic approach (inductive and deductive) for analysis that was assisted by MAXQDA 12 software. Infrastructures needed for the implementation of FP were categorized in five main themes and 23 subthemes. The themes are: 'Stewardship/governance', 'Actors and stakeholders', 'structural infrastructure', 'technical infrastructure and needed resources', and 'information and communication infrastructure'. Expansion of FP program to urban settings needs appropriate attention to the principles of policy implementation as well as provision of robust infrastructures. Well-defined stewardship, revised approach to financial regulation and payment system, stakeholder's commitment to collaboration, policy for conflict resolution, and universal insurance coverage are pivotal for the expansion of family physician program to the urban settings in Iran.

  14. Identification of Cis-Acting Elements on Positive-Strand Subgenomic mRNA Required for the Synthesis of Negative-Strand Counterpart in Bovine Coronavirus

    Directory of Open Access Journals (Sweden)

    Po-Yuan Yeh

    2014-07-01

    Full Text Available It has been demonstrated that, in addition to genomic RNA, sgmRNA is able to serve as a template for the synthesis of the negative-strand [(−-strand] complement. However, the cis-acting elements on the positive-strand [(+-strand] sgmRNA required for (−-strand sgmRNA synthesis have not yet been systematically identified. In this study, we employed real-time quantitative reverse transcription polymerase chain reaction to analyze the cis-acting elements on bovine coronavirus (BCoV sgmRNA 7 required for the synthesis of its (−-strand counterpart by deletion mutagenesis. The major findings are as follows. (1 Deletion of the 5'-terminal leader sequence on sgmRNA 7 decreased the synthesis of the (−-strand sgmRNA complement. (2 Deletions of the 3' untranslated region (UTR bulged stem-loop showed no effect on (−-strand sgmRNA synthesis; however, deletion of the 3' UTR pseudoknot decreased the yield of (−-strand sgmRNA. (3 Nucleotides positioned from −15 to −34 of the sgmRNA 7 3'-terminal region are required for efficient (−-strand sgmRNA synthesis. (4 Nucleotide species at the 3'-most position (−1 of sgmRNA 7 is correlated to the efficiency of (−-strand sgmRNA synthesis. These results together suggest, in principle, that the 5'- and 3'-terminal sequences on sgmRNA 7 harbor cis-acting elements are critical for efficient (−-strand sgmRNA synthesis in BCoV.

  15. Asymmetric division and differential gene expression during a bacterial developmental program requires DivIVA.

    Directory of Open Access Journals (Sweden)

    Prahathees Eswaramoorthy

    2014-08-01

    Full Text Available Sporulation in the bacterium Bacillus subtilis is a developmental program in which a progenitor cell differentiates into two different cell types, the smaller of which eventually becomes a dormant cell called a spore. The process begins with an asymmetric cell division event, followed by the activation of a transcription factor, σF, specifically in the smaller cell. Here, we show that the structural protein DivIVA localizes to the polar septum during sporulation and is required for asymmetric division and the compartment-specific activation of σF. Both events are known to require a protein called SpoIIE, which also localizes to the polar septum. We show that DivIVA copurifies with SpoIIE and that DivIVA may anchor SpoIIE briefly to the assembling polar septum before SpoIIE is subsequently released into the forespore membrane and recaptured at the polar septum. Finally, using super-resolution microscopy, we demonstrate that DivIVA and SpoIIE ultimately display a biased localization on the side of the polar septum that faces the smaller compartment in which σF is activated.

  16. [Health risks and economic costs associated with obesity requiring a comprehensive weight reduction program].

    Science.gov (United States)

    Hainer, V; Kunesová, M; Parízková, J; Stunkard, A

    1997-06-12

    An increasing prevalence of obesity all over the world reflects a lack of effective measures in both prevention and treatment of obesity. Obesity as a disease has been underestimated by the lay-public as well as health care providers. However, obesity represents a substantial health problem associated with a decreased quality of life. Obesity is linked to numerous chronic diseases (cardiovascular diseases, diabetes, hyperlipidemia, gout, osteoarthritis, gall-stones, and bowel, breast and genitourinary cancers) that lead to premature disability and mortality. Health risks increase with a body mass index (BMI) over 25 in individuals 19-35 years of age and with a BMI over 27 in those 35 years of age and older. Health risks also increase with an excess accumulation of visceral fat manifested as an increase in waist circumference (> 100 cm) or in waist to hip ratio (> 0.85 for females and > 1.00 for males). According to studies carried out in different countries current economic costs of obesity represent 5-8% of all direct health costs. In contrast, effective treatment of obesity results in a substantial decrease in expenditures associated with pharmacotherapy of hypertension, diabetes, hyperlipidemia and osteoarthritis. Both scientists and clinicians involved in obesity research and treatment recommend to introduce the long-term weight management programs focussing more on the overall health of the participants than the weight loss per se. Therefore, it will be necessary to establish new realistic goals in the obesity management that reflect reasonable weights and recently experienced beneficial health effects of modest (5-10%) weight loss. Comprehensive obesity treatment consisting of low fat diet, exercise, behavioral modification, drug therapy and surgical procedures requires differentiated weight management programs modified according to the degree and type of obesity as well as to current health complications present. The Czech Society for the Study of Obesity

  17. The HIV-1 Rev/RRE system is required for HIV-1 5' UTR cis elements to augment encapsidation of heterologous RNA into HIV-1 viral particles

    Directory of Open Access Journals (Sweden)

    Ma Hong

    2011-06-01

    Full Text Available Abstract Background The process of HIV-1 genomic RNA (gRNA encapsidation is governed by a number of viral encoded components, most notably the Gag protein and gRNA cis elements in the canonical packaging signal (ψ. Also implicated in encapsidation are cis determinants in the R, U5, and PBS (primer binding site from the 5' untranslated region (UTR. Although conventionally associated with nuclear export of HIV-1 RNA, there is a burgeoning role for the Rev/RRE in the encapsidation process. Pleiotropic effects exhibited by these cis and trans viral components may confound the ability to examine their independent, and combined, impact on encapsidation of RNA into HIV-1 viral particles in their innate viral context. We systematically reconstructed the HIV-1 packaging system in the context of a heterologous murine leukemia virus (MLV vector RNA to elucidate a mechanism in which the Rev/RRE system is central to achieving efficient and specific encapsidation into HIV-1 viral particles. Results We show for the first time that the Rev/RRE system can augment RNA encapsidation independent of all cis elements from the 5' UTR (R, U5, PBS, and ψ. Incorporation of all the 5' UTR cis elements did not enhance RNA encapsidation in the absence of the Rev/RRE system. In fact, we demonstrate that the Rev/RRE system is required for specific and efficient encapsidation commonly associated with the canonical packaging signal. The mechanism of Rev/RRE-mediated encapsidation is not a general phenomenon, since the combination of the Rev/RRE system and 5' UTR cis elements did not enhance encapsidation into MLV-derived viral particles. Lastly, we show that heterologous MLV RNAs conform to transduction properties commonly associated with HIV-1 viral particles, including in vivo transduction of non-dividing cells (i.e. mouse neurons; however, the cDNA forms are episomes predominantly in the 1-LTR circle form. Conclusions Premised on encapsidation of a heterologous RNA into

  18. Analysis of Helicobacter pylori cagA promoter elements required for salt-induced upregulation of CagA expression.

    Science.gov (United States)

    Loh, John T; Friedman, David B; Piazuelo, M Blanca; Bravo, Luis E; Wilson, Keith T; Peek, Richard M; Correa, Pelayo; Cover, Timothy L

    2012-09-01

    Helicobacter pylori infection and consumption of a high-salt diet are each associated with an increased risk for the development of gastric cancer. To investigate potential synergism between these factors, we used a global proteomic approach to analyze H. pylori strains cultured in media containing varying salt concentrations. Among the differentially expressed proteins identified, CagA exhibited the greatest increase in expression in response to high salt concentrations. Analysis of 36 H. pylori strains isolated from patients in two regions of Colombia with differing incidences of gastric cancer revealed marked differences among strains in salt-responsive CagA expression. Sequence analysis of the cagA promoter region in these strains revealed a DNA motif (TAATGA) that was present in either one or two copies. Salt-induced upregulation of CagA expression was detected more commonly in strains containing two copies of the TAATGA motif than in strains containing one copy. Mutagenesis experiments confirmed that two copies of the TAATGA motif are required for salt-induced upregulation of CagA expression. In summary, there is considerable heterogeneity among H. pylori strains in salt-regulated CagA expression, and these differences are attributable to variation in a specific DNA motif upstream of the cagA transcriptional start site.

  19. An overview of fiber-to-the-premises (FTTP) product requirements and qualification programs

    Science.gov (United States)

    Gebizlioglu, Osman S.; Gallo, Ernest J.

    2006-04-01

    North American deployments of FTTP architectures have been rapidly increasing. While the FTTP market is being driven by major telecommunications service providers, equipment suppliers have been scrambling to bring products to market that will ensure them a piece of this high-stakes market. In this invited presentation/paper, we propose to examine the technical requirements that are needed to support the new FTTP network with a host of new products that have been in development. To enable service providers select the best new products for FTTP deployment, product selection needs to be based on the analysis and testing of new products for performance and reliability, Telcordia, in its traditional role of telecommunications standards development, has been publishing generic requirements (GR) documents that have been used by suppliers, service providers and the industry at large. Product qualification programs based on the established performance and reliability requirements/standards have been designed to evaluate products to determine if they can 1) withstand the rigors of the outside plant deployment environment and perform for extended periods of time, 2) be upgradeable, and 3) craft friendly. The outside plant is a tough environment to live in. A product must perform under the extreme conditions of cold down -40°C (-40°F) and hot up to 46°C (115°F) with high humidity of 95%, rain, snow, sleet, vibration due to traffic, lightning, heating due to solar loads, high winds, ice, sand storms, and products are even tested to demonstrate if they can continue to operate in an earthquake, a wild fire and a shotgun blast. All FTTP products are not only expected to perform, but they must meet stringent optical performance criteria of low insertion loss and reflectance / return loss at a broad range of wavelengths from 1310, 1490, 1550 and 1625 nm. While the upstream (from the customer to the CO) voice and data transmission is currently planned over 1310-nm wavelength, the

  20. Pancreatic β cell identity requires continual repression of non–β cell programs

    Science.gov (United States)

    Gutiérrez, Giselle Domínguez; Bender, Aaron S.; Cirulli, Vincenzo; Mastracci, Teresa L.; Kelly, Stephen M.; Tsirigos, Aristotelis; Kaestner, Klaus H.

    2016-01-01

    Loss of β cell identity, the presence of polyhormonal cells, and reprogramming are emerging as important features of β cell dysfunction in patients with type 1 and type 2 diabetes. In this study, we have demonstrated that the transcription factor NKX2.2 is essential for the active maintenance of adult β cell identity as well as function. Deletion of Nkx2.2 in β cells caused rapid onset of a diabetic phenotype in mice that was attributed to loss of insulin and downregulation of many β cell functional genes. Concomitantly, NKX2.2-deficient murine β cells acquired non–β cell endocrine features, resulting in populations of completely reprogrammed cells and bihormonal cells that displayed hybrid endocrine cell morphological characteristics. Molecular analysis in mouse and human islets revealed that NKX2.2 is a conserved master regulatory protein that controls the acquisition and maintenance of a functional, monohormonal β cell identity by directly activating critical β cell genes and actively repressing genes that specify the alternative islet endocrine cell lineages. This study demonstrates the highly volatile nature of the β cell, indicating that acquiring and sustaining β cell identity and function requires not only active maintaining of the expression of genes involved in β cell function, but also continual repression of closely related endocrine gene programs. PMID:27941248

  1. Pancreatic β cell identity requires continual repression of non-β cell programs.

    Science.gov (United States)

    Gutiérrez, Giselle Domínguez; Bender, Aaron S; Cirulli, Vincenzo; Mastracci, Teresa L; Kelly, Stephen M; Tsirigos, Aristotelis; Kaestner, Klaus H; Sussel, Lori

    2017-01-03

    Loss of β cell identity, the presence of polyhormonal cells, and reprogramming are emerging as important features of β cell dysfunction in patients with type 1 and type 2 diabetes. In this study, we have demonstrated that the transcription factor NKX2.2 is essential for the active maintenance of adult β cell identity as well as function. Deletion of Nkx2.2 in β cells caused rapid onset of a diabetic phenotype in mice that was attributed to loss of insulin and downregulation of many β cell functional genes. Concomitantly, NKX2.2-deficient murine β cells acquired non-β cell endocrine features, resulting in populations of completely reprogrammed cells and bihormonal cells that displayed hybrid endocrine cell morphological characteristics. Molecular analysis in mouse and human islets revealed that NKX2.2 is a conserved master regulatory protein that controls the acquisition and maintenance of a functional, monohormonal β cell identity by directly activating critical β cell genes and actively repressing genes that specify the alternative islet endocrine cell lineages. This study demonstrates the highly volatile nature of the β cell, indicating that acquiring and sustaining β cell identity and function requires not only active maintaining of the expression of genes involved in β cell function, but also continual repression of closely related endocrine gene programs.

  2. Histone Deacetylase Is Required for GA-Induced Programmed Cell Death in Maize Aleurone Layers.

    Science.gov (United States)

    Hou, Haoli; Zheng, Xueke; Zhang, Hao; Yue, Mengxia; Hu, Yan; Zhou, Hong; Wang, Qing; Xie, Chengshen; Wang, Pu; Li, Lijia

    2017-11-01

    Recent discoveries have shown that epigenetic regulation is an integral part of phytohormone-mediated processes. The phytohormone gibberellin (GA) triggers a series of events in cereal aleurone cells that lead to programmed cell death (PCD), but the signaling cascade mediating GA-induced PCD in cereal aleurone layers remains largely unknown. Here, we showed that histone deacetylase (HDAC) activity gradually increased relative to histone acetyltransferase (HAT) activity, leading to a global decrease in histone H3 and H4 acetylation levels during PCD of maize (Zea mays) embryoless aleurone layers after 3 d of treatment with GA. HDAC inhibition prevented GA-induced PCD in embryoless aleurone cells, whereas HAT inhibition resulted in PCD even in the absence of GA. Hydrogen peroxide concentrations increased in GA- or HAT inhibitor-treated aleurone cells due to reduced levels of reactive oxygen species scavengers. Hydrogen peroxide-treated aleurone cells showed no changes in the activity or expression of HATs and HDACs. We show that it is possible to predict whether epigenetic modification enzymes serve as a regulator of the GA-triggered PCD signaling pathway in maize aleurone layers. Taken together, these findings reveal that HDAC activity is required for GA-induced PCD in maize aleurone layers and regulates PCD via the reactive oxygen species-mediated signal transduction pathway. © 2017 American Society of Plant Biologists. All Rights Reserved.

  3. Achievement of Weight Loss and Other Requirements of the Diabetes Prevention and Recognition Program: A National Diabetes Prevention Program Network Based on Nationally Certified Diabetes Self-management Education Programs.

    Science.gov (United States)

    DiBenedetto, Joanna Craver; Blum, Natalie M; O'Brian, Catherine A; Kolb, Leslie E; Lipman, Ruth D

    2016-12-01

    The purpose of this report is (1) to describe the use of the American Association of Diabetes Educators' (AADE's) model of implementation of the National Diabetes Prevention Program through nationally certified diabetes self-management education (DSME) programs and (2) to report the aggregated program outcomes as defined by the Diabetes Prevention and Recognition Program standards of the Centers for Disease Control and Prevention (CDC). In 2012, the AADE worked with the CDC to select 30 certified DSME programs for National Diabetes Prevention Program delivery. For the following 3 years, the AADE continued to work with 25 of the 30 original programs. Results for all CDC recognition standards have been collected from these 25 programs and analyzed as aggregated data over the course of 36 months. At the end of the full-year program, average percentage body weight loss for participants across all 25 programs exceeded the CDC's minimum requirement of 5% weight loss. All programs on average met the CDC requirements for program attendance. Increasing access to the National Diabetes Prevention Program, through an array of networks, including certified DSME programs, will better ensure that people are able to engage in an effective approach to reducing their risk of diabetes. © 2016 The Author(s).

  4. Image data processing system requirements study. Volume 1: Analysis. [for Earth Resources Survey Program

    Science.gov (United States)

    Honikman, T.; Mcmahon, E.; Miller, E.; Pietrzak, L.; Yorsz, W.

    1973-01-01

    Digital image processing, image recorders, high-density digital data recorders, and data system element processing for use in an Earth Resources Survey image data processing system are studied. Loading to various ERS systems is also estimated by simulation.

  5. 75 FR 5248 - Requirements and Procedures for Consumer Assistance To Recycle and Save Program

    Science.gov (United States)

    2010-02-02

    ... for Consumer Assistance To Recycle and Save Program AGENCY: National Highway Traffic Safety... the regulations implementing the Consumer Assistance to Recycle and Save (CARS) program, published on... implementing the Consumer Assistance to Recycle and Save (CARS) program, published on July 29, 2009 in the...

  6. 77 FR 4688 - National School Lunch Program: Direct Certification Continuous Improvement Plans Required by the...

    Science.gov (United States)

    2012-01-31

    ... the NSLP and/or School Breakfast Program to establish, by school year (SY) 2008-2009, a system to... effects, distributive impacts, and equity). Executive Order 13563 emphasizes the importance of quantifying... breakfast and lunch programs. 7 CFR Part 272 Alaska, Civil rights, Claims, Food stamps, Grant programs...

  7. Electronic Devices, Methods, and Computer Program Products for Selecting an Antenna Element Based on a Wireless Communication Performance Criterion

    DEFF Research Database (Denmark)

    2014-01-01

    A method of operating an electronic device includes providing a plurality of antenna elements, evaluating a wireless communication performance criterion to obtain a performance evaluation, and assigning a first one of the plurality of antenna elements to a main wireless signal reception and trans...

  8. The pioneer factor OCT4 requires the chromatin remodeller BRG1 to support gene regulatory element function in mouse embryonic stem cells.

    Science.gov (United States)

    King, Hamish W; Klose, Robert J

    2017-03-13

    Pioneer transcription factors recognise and bind their target sequences in inaccessible chromatin to establish new transcriptional networks throughout development and cellular reprogramming. During this process, pioneer factors establish an accessible chromatin state to facilitate additional transcription factor binding, yet it remains unclear how different pioneer factors achieve this. Here, we discover that the pluripotency-associated pioneer factor OCT4 binds chromatin to shape accessibility, transcription factor co-binding, and regulatory element function in mouse embryonic stem cells. Chromatin accessibility at OCT4-bound sites requires the chromatin remodeller BRG1, which is recruited to these sites by OCT4 to support additional transcription factor binding and expression of the pluripotency-associated transcriptome. Furthermore, the requirement for BRG1 in shaping OCT4 binding reflects how these target sites are used during cellular reprogramming and early mouse development. Together this reveals a distinct requirement for a chromatin remodeller in promoting the activity of the pioneer factor OCT4 and regulating the pluripotency network.

  9. Targeted deletion of multiple CTCF-binding elements in the human C-MYC gene reveals a requirement for CTCF in C-MYC expression.

    Directory of Open Access Journals (Sweden)

    Wendy M Gombert

    Full Text Available BACKGROUND: Insulators and domain boundaries both shield genes from adjacent enhancers and inhibit intrusion of heterochromatin into transgenes. Previous studies examined the functional mechanism of the MYC insulator element MINE and its CTCF binding sites in the context of transgenes that were randomly inserted into the genome by transfection. However, the contribution of CTCF binding sites to both gene regulation and maintenance of chromatin has not been tested at the endogenous MYC gene. METHODOLOGY/PRINCIPAL FINDINGS: To determine the impact of CTCF binding on MYC expression, a series of mutant human chromosomal alleles was prepared in homologous recombination-efficient DT40 cells and individually transferred by microcell fusion into murine cells. Functional tests reported here reveal that deletion of CTCF binding elements within the MINE does not impact the capacity of this locus to correctly organize an 'accessible' open chromatin domain, suggesting that these sites are not essential for the formation of a competent, transcriptionally active locus. Moreover, deletion of the CTCF site at the MYC P2 promoter reduces transcription but does not affect promoter acetylation or serum-inducible transcription. Importantly, removal of either CTCF site leads to DNA methylation of flanking sequences, thereby contributing to progressive loss of transcriptional activity. CONCLUSIONS: These findings collectively demonstrate that CTCF-binding at the human MYC locus does not repress transcriptional activity but is required for protection from DNA methylation.

  10. 78 FR 56575 - Changes to the Home Equity Conversion Mortgage Program Requirements: Financial Assessments...

    Science.gov (United States)

    2013-09-12

    ... assessment requirements and funding requirements for the payment of property charges, the new HECM... assessment requirements and the funding requirements for payment of property charges take effect for case numbers assigned on or after January 13, 2014. This notice solicits comment for a period of 30 days on the...

  11. Qualification requirements and training programs for nonreactor nuclear facility personnel in the Operations Division of the Oak Ridge National Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Preston, E.L.; Culbert, W.H.; Baldwin, M.E.; McCormack, K.E.; Rivera, A.L.; Setaro, J.A.

    1985-11-01

    This document describes the program for training, retraining, and qualification of nonreactor nuclear operators in the Operations Division of the Oak Ridge National Laboratory. The objective of the program is to provide the Operators and Supervisors of nuclear facilities the knowledge and skills needed to perform assigned duties in a safe and efficient manner and to comply with US Department of Energy Order 5480.1A Chapter V. This order requires DOE nuclear facilities to maintain formal training programs for their operating staff and documentation of that training.

  12. Highly precise and developmentally programmed genome assembly in Paramecium requires ligase IV-dependent end joining.

    Directory of Open Access Journals (Sweden)

    Aurélie Kapusta

    2011-04-01

    Full Text Available During the sexual cycle of the ciliate Paramecium, assembly of the somatic genome includes the precise excision of tens of thousands of short, non-coding germline sequences (Internal Eliminated Sequences or IESs, each one flanked by two TA dinucleotides. It has been reported previously that these genome rearrangements are initiated by the introduction of developmentally programmed DNA double-strand breaks (DSBs, which depend on the domesticated transposase PiggyMac. These DSBs all exhibit a characteristic geometry, with 4-base 5' overhangs centered on the conserved TA, and may readily align and undergo ligation with minimal processing. However, the molecular steps and actors involved in the final and precise assembly of somatic genes have remained unknown. We demonstrate here that Ligase IV and Xrcc4p, core components of the non-homologous end-joining pathway (NHEJ, are required both for the repair of IES excision sites and for the circularization of excised IESs. The transcription of LIG4 and XRCC4 is induced early during the sexual cycle and a Lig4p-GFP fusion protein accumulates in the developing somatic nucleus by the time IES excision takes place. RNAi-mediated silencing of either gene results in the persistence of free broken DNA ends, apparently protected against extensive resection. At the nucleotide level, controlled removal of the 5'-terminal nucleotide occurs normally in LIG4-silenced cells, while nucleotide addition to the 3' ends of the breaks is blocked, together with the final joining step, indicative of a coupling between NHEJ polymerase and ligase activities. Taken together, our data indicate that IES excision is a "cut-and-close" mechanism, which involves the introduction of initiating double-strand cleavages at both ends of each IES, followed by DSB repair via highly precise end joining. This work broadens our current view on how the cellular NHEJ pathway has cooperated with domesticated transposases for the emergence of new

  13. Atomic Structure and Valence: Level II, Unit 10, Lesson 1; Chemical Bonding: Lesson 2; The Table of Elements: Lesson 3; Electrolysis: Lesson 4. Advanced General Education Program. A High School Self-Study Program.

    Science.gov (United States)

    Manpower Administration (DOL), Washington, DC. Job Corps.

    This self-study program for high-school level contains lessons on: Atomic Structure and Valence, Chemical Bonding, The Table of Elements, and Electrolysis. Each of the lessons concludes with a Mastery Test to be completed by the student. (DB)

  14. "Braingame Brian": Toward an Executive Function Training Program with Game Elements for Children with ADHD and Cognitive Control Problems.

    Science.gov (United States)

    Prins, Pier J M; Brink, Esther Ten; Dovis, Sebastiaan; Ponsioen, Albert; Geurts, Hilde M; de Vries, Marieke; van der Oord, Saskia

    2013-02-01

    In the area of childhood attention-deficit hyperactivity disorder, there is an urgent need for new, innovative, and child-focused treatments. A computerized executive functioning training with game elements aimed at enhancing self-control was developed. The first results are promising, and the next steps involve replication with larger samples, evaluating transfer of training effects to daily life, and enhancing motivation through more gaming elements.

  15. Spanish-Language Community-Based Mental Health Treatment Programs, Policy-Required Language-Assistance Programming, and Mental Health Treatment Access Among Spanish-Speaking Clients

    Science.gov (United States)

    McClellan, Sean R.

    2013-01-01

    Objectives. We investigated the extent to which implementing language assistance programming through contracting with community-based organizations improved the accessibility of mental health care under Medi-Cal (California’s Medicaid program) for Spanish-speaking persons with limited English proficiency, and whether it reduced language-based treatment access disparities. Methods. Using a time series nonequivalent control group design, we studied county-level penetration of language assistance programming over 10 years (1997–2006) for Spanish-speaking persons with limited English proficiency covered under Medi-Cal. We used linear regression with county fixed effects to control for ongoing trends and other influences. Results. When county mental health plans contracted with community-based organizations, those implementing language assistance programming increased penetration rates of Spanish-language mental health services under Medi-Cal more than other plans (0.28 percentage points, a 25% increase on average; P language-related disparities. Conclusions. Mental health treatment programs operated by community-based organizations may have moderately improved access after implementing required language assistance programming, but the programming did not reduce entrenched disparities in the accessibility of mental health services. PMID:23865663

  16. Spanish-language community-based mental health treatment programs, policy-required language-assistance programming, and mental health treatment access among Spanish-speaking clients.

    Science.gov (United States)

    Snowden, Lonnie R; McClellan, Sean R

    2013-09-01

    We investigated the extent to which implementing language assistance programming through contracting with community-based organizations improved the accessibility of mental health care under Medi-Cal (California's Medicaid program) for Spanish-speaking persons with limited English proficiency, and whether it reduced language-based treatment access disparities. Using a time series nonequivalent control group design, we studied county-level penetration of language assistance programming over 10 years (1997-2006) for Spanish-speaking persons with limited English proficiency covered under Medi-Cal. We used linear regression with county fixed effects to control for ongoing trends and other influences. When county mental health plans contracted with community-based organizations, those implementing language assistance programming increased penetration rates of Spanish-language mental health services under Medi-Cal more than other plans (0.28 percentage points, a 25% increase on average; P language-related disparities. Mental health treatment programs operated by community-based organizations may have moderately improved access after implementing required language assistance programming, but the programming did not reduce entrenched disparities in the accessibility of mental health services.

  17. 7 CFR 4280.36 - Other laws that contain compliance requirements for these Programs.

    Science.gov (United States)

    2010-01-01

    ... (Continued) RURAL BUSINESS-COOPERATIVE SERVICE AND RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE LOANS AND GRANTS Rural Economic Development Loan and Grant Programs § 4280.36 Other laws that contain... applicable to these Programs and to the loans made from the Revolving Loan Fund using Rural Development funds...

  18. 75 FR 28554 - Elimination of Classification Requirement in the Green Technology Pilot Program

    Science.gov (United States)

    2010-05-21

    ...: The United States Patent and Trademark Office (USPTO) implemented the Green Technology Pilot Program... promote the development of green technologies. However, the pilot program was limited to only applications... denial of petitions for applications that are drawn to green technologies. The USPTO is hereby...

  19. 78 FR 730 - State Program Requirements; Approval of Application To Administer Partial National Pollutant...

    Science.gov (United States)

    2013-01-04

    ... Elimination System program under the Clean Water Act. SUMMARY: On December 20, 2012, the Regional... pursuant to Section 402(b) of the Clean Water Act (CWA or ``the Act''). The AgPDES program will be..., Texas 75202. A copy of ODAFF's application is available online at the EPA Region 6 web page: http://www...

  20. Developing Software Requirements for a Knowledge Management System That Coordinates Training Programs with Business Processes and Policies in Large Organizations

    Science.gov (United States)

    Kiper, J. Richard

    2013-01-01

    For large organizations, updating instructional programs presents a challenge to keep abreast of constantly changing business processes and policies. Each time a process or policy changes, significant resources are required to locate and modify the training materials that convey the new content. Moreover, without the ability to track learning…

  1. A Census of Statistics Requirements at U.S. Journalism Programs and a Model for a "Statistics for Journalism" Course

    Science.gov (United States)

    Martin, Justin D.

    2017-01-01

    This essay presents data from a census of statistics requirements and offerings at all 4-year journalism programs in the United States (N = 369) and proposes a model of a potential course in statistics for journalism majors. The author proposes that three philosophies underlie a statistics course for journalism students. Such a course should (a)…

  2. Investigation and Development of Competency Standards and Certification Requirements for Secondary-Level Vocational Foodservice Programs. Final Report.

    Science.gov (United States)

    Usiewicz, Ronald A.

    An investigation ascertained, analyzed, and documented competency standards and certification requirements for secondary-level vocational food service programs. A literature review produced no instruments used in past studies to measure the attitudes of food service professionals toward task competencies. Six occupations were selected for the…

  3. 34 CFR 379.10 - What types of project activities are required of each grantee under this program?

    Science.gov (United States)

    2010-07-01

    ... placement and career advancement opportunities; (b) Provide job development, job placement, and career... 34 Education 2 2010-07-01 2010-07-01 false What types of project activities are required of each grantee under this program? 379.10 Section 379.10 Education Regulations of the Offices of the Department...

  4. 34 CFR 694.10 - What are the requirements for awards under the program's scholarship component under section 404E...

    Science.gov (United States)

    2010-07-01

    ...'s scholarship component under section 404E of the HEA? 694.10 Section 694.10 Education Regulations... What are the requirements for awards under the program's scholarship component under section 404E of the HEA? (a) Amount of scholarship. (1) Except as provided in paragraph (a)(2) of this section, the...

  5. Understanding the Negative Graduate Student Perceptions of Required Statistics and Research Methods Courses: Implications for Programs and Faculty

    Science.gov (United States)

    Coleman, Charles; Conrad, Cynthia

    2007-01-01

    The authors of this study endeavor to explore the negative opinions and perceptions of graduate students in business and social science programs, regarding their required statistics and research methods courses. The general sense of instructors of such courses is that students dread and resent having to take courses dealing with statistics and…

  6. One Methodology for Proving Compliance to the Commercial Crew Program (CCP) Abort Capability Requirement

    Science.gov (United States)

    Proud, Ryan; Adam, Jason

    2011-01-01

    As of Draft 4.0 of the CCT-REQ-1130 requirements document for CCP, ISS Crew Transportation and Services Requirements Document, specific language for the verification of the abort capability requirement, 3.3.1.4, was added. The abort capability requirement ensures that the CTS under dispersed conditions is always capable of aborting from a failed LV. The Integrated Aborts IPT was asked to author a memo for how this verification might be completed. The following memo dictates one way that this requirement and its verification could be met, but this is the not the only method.

  7. Study and determination of elemental impurities by ICP-MS in active pharmaceutical ingredients using single reaction chamber digestion in compliance with USP requirements.

    Science.gov (United States)

    Muller, Aline L H; Oliveira, Jussiane S S; Mello, Paola A; Muller, Edson I; Flores, Erico M M

    2015-05-01

    In this work a method for active pharmaceutical ingredients (APIs) digestion using the single reaction chamber (SRC-UltraWave™) system was proposed following the new recommendations of United States Pharmacopeia (USP). Levodope (LEVO), primaquine diphosphate (PRIM), propranolol hydrochloride (PROP) and sulfamethoxazole (SULF) were used to evaluate the digestion efficiency of the proposed method. A comparison of digestion efficiency was performed by measuring the carbon content and residual acidity in digests obtained using SRC and in digests obtained using conventional microwave-assisted digestion system (Multiwave(TM)). Three digestion solutions (concentrated HNO3, aqua regia or inverse aqua regia) were evaluated for digestion of APIs. The determination of Cd, Ir, Mn, Mo, Ni, Os, Pb, Pd, Pt, Rh, Ru was performed using inductively coupled plasma mass spectrometry (ICP-MS) in standard mode. Dynamic reaction cell (DRC) mode was used for the determination of (51)V, (52)Cr, (53)Cr, (63)Cu and (65)Cu in order to solve polyatomic ion interferences. Arsenic and Hg were determined using chemical vapor generation coupled to ICP-MS (FI-CVG-ICP-MS). Masses of 500mg of APIs were efficiently digested in a SRC-UltraWave™ system using only HNO3 and allowing a carbon content lower than 250mg L(-1) in final digests. Inverse aqua regia was suitable for digestion of sample masses up to 250mg allowing the determination of Ir, Pd, Pt, Rh and Ru. By using HNO3 or inverse aqua regia, suitable recoveries were obtained (between 91 and 109%) for all analytes (exception for Os). Limits of quantification were in agreement with USP requirements and they ranged from 0.001 to 0.015µg g(-1) for all elemental impurities (exception for Os). The proposed method was suitable for elemental impurities determination in APIs and it can be used in routine analysis for quality control in pharmaceutical industries. Copyright © 2014 Elsevier B.V. All rights reserved.

  8. 40 CFR 80.1454 - What are the recordkeeping requirements under the RFS program?

    Science.gov (United States)

    2010-07-01

    ... paper, cardboard, plastics, rubber, textiles, metals, and glass separated from municipal solid waste for... management plan for agricultural or silvicultural purposes; documentation of participation in an agricultural... of land management in accordance with an agricultural or silvicultural product certification program...

  9. 40 CFR 80.1464 - What are the attest engagement requirements under the RFS program?

    Science.gov (United States)

    2010-07-01

    ... the obligated party's or exporter's RVOs, and any deficit RVOs carried over from the previous year or... section shall identify and report as a finding the commercial computer program used by the party to track...

  10. No tests required : comparing traditional and dynamic predictors of programming success.

    OpenAIRE

    Watson, Christopher; Frederick W.B. Li; Godwin, Jamie L.

    2014-01-01

    Research over the past fifty years into predictors of programming performance has yielded little improvement in the identification of at-risk students. This is possibly because research to date is based upon using static tests, which fail to reflect changes in a student's learning progress over time. In this paper, the effectiveness of 38 traditional predictors of programming performance are compared to 12 new data-driven predictors, that are based upon analyzing directly logged data, describ...

  11. Trends in Canadian faculties of education: An overview of graduate programs, curricular offerings, exit requirements, and modes of delivery.

    Directory of Open Access Journals (Sweden)

    Carla Abreu Ellis

    2008-07-01

    Full Text Available Introduction This research investigated universities registered with the Association of Universities and Colleges of Canada (AUCC whose primary instructional language was English. A content analysis was performed on university web pages related to the following content: (a frequency of graduate programs being offered, (b types of degrees being offered, (c frequency and variation of program of study offerings, (d variation of exit requirements, and (e modalities of course delivery. This research provides an overview and analysis of graduate level programs, more precisely Masters and Doctorate degrees, offered through faculties of education in Canada. An understanding of the findings of this research may benefit Canadian university administrative bodies in providing a source in which they may compare findings with their current offerings and programming. Prospective students of graduate programs in education may also benefit from the information provided in this study when choosing a program of study by ameliorating their knowledge of current programs, curriculum offerings, and modes of course delivery being offered by faculties of education in Canada.

  12. The National Shipbuilding Research Program. Acceptance Standards for Nondestructive Test Not Required by Classification (Phase 2)

    National Research Council Canada - National Science Library

    Stern, I. L; Wheatcroft, M; Ku, D. Y; Cantore, D

    1985-01-01

    Current ABS requirements relative to nondestructive test and acceptance standards for radiographic and ultrasonic inspection are mainly intended for intersecting full penetration welds within the midship...

  13. Minimum Stocking Requirements for Retailers in the Special Supplemental Nutrition Program for Women, Infants, and Children: Disparities Across US States.

    Science.gov (United States)

    Pelletier, Jennifer E; Schreiber, Liana R N; Laska, Melissa N

    2017-07-01

    To examine state variation in minimum stocking requirements for Special Supplemental Nutrition Program for Women, Infants, and Children (WIC)-authorized small food retailers. We obtained minimum stocking requirements for 50 states and the District of Columbia in 2017 from WIC Web pages or e-mail from the state WIC agency. We developed a coding protocol to compare minimum quantities and varieties required for 12 food and beverage categories. We calculated the median, range, and interquartile range for each measure. Nearly all states set minimum varieties and quantities of fruits and vegetables, 100% juice, whole grain-rich foods, breakfast cereal, milk, cheese, eggs, legumes, and peanut butter. Fewer states set requirements for canned fish, yogurt, and tofu. Most measures had a large range in minimum requirements (e.g., $8-$100 of fruits and vegetables, 60-144 oz of breakfast cereal). WIC-participating retailers must adhere to very different minimum stocking requirements across states, which may result in disparities in food and beverage products available to WIC recipients. Public Health Implications. The results provide benchmarks that can inform new local, state, and federal program and policy efforts to increase healthy food availability in retail settings.

  14. 12 CFR 1732.6 - Minimum requirements of record retention program.

    Science.gov (United States)

    2010-01-01

    ... retained records and the retention period— (i) Are adequate to support litigation and the administrative, business, external and internal audit functions of the Enterprise; (ii) Comply with requirements of..., and operational and business requirements; (6) Include adequate security and internal controls to...

  15. "Braingame Brian": Toward an Executive Function Training Program with Game Elements for Children with ADHD and Cognitive Control Problems

    NARCIS (Netherlands)

    Prins, P.J.M.; ten Brink, E.; Dovis, S.; Ponsioen, A.; Geurts, H.M.; de Vries, M.; van der Oord, S.

    2013-01-01

    In the area of childhood attention-deficit hyperactivity disorder, there is an urgent need for new, innovative, and child-focused treatments. A computerized executive functioning training with game elements aimed at enhancing self-control was developed. The first results are promising, and the next

  16. REQUIREMENTS TO AUTOMATIZATION PROCESSING IN THE PROGRAMMING INFORMATION SYSTEM OF SCIENTIFIC RESEARCHES IN ACADEMY OF PEDAGOGICAL SCIENCES OF UKRAINE

    Directory of Open Access Journals (Sweden)

    Alla V. Kilchenko

    2010-08-01

    Full Text Available A construction and introduction of the information systems in a management education is the actual task of forming of modern information society. In the article the results of research of automation of treatment of financial documents, which was conducted within the project «Scientific-methodical providing of the informative system of programming of scientific researches in Academy of Pedagogical Sciences of Ukraine based on the Internet» № 0109U002139 are represented. The article contains methodical principles of automation of treatment programming and financial documents as well as requirements to the information system, which will be the base to next project stages.

  17. INTERNATIONAL REQUIRMENTS ANALYSIS APPLIED AT PROGRAM SYSTEMS DESIGN FOR AERONAUTICAL SPECIALISTS TRAINING

    Directory of Open Access Journals (Sweden)

    P. A. Kolokolnikov

    2015-01-01

    Full Text Available This article analyzes the international requirements being taken in to account when building a system of aviation specialists training whose activities are related to the sphere of aircraft airworthiness and aviation safety. The content of normative and technical documentation is considered, provisions related to the international standards requirements and a set of documents on the certification of aviation specialists training are analyzed.

  18. National School Lunch Program and School Breakfast Program: Eliminating Applications Through Community Eligibility as Required by the Healthy, Hunger-Free Kids Act of 2010. Final rule.

    Science.gov (United States)

    2016-07-29

    This final rule establishes requirements for State agencies, local educational agencies, and schools operating the Community Eligibility Provision, a reimbursement option that allows the service of school meals to all children at no-cost in high poverty schools without collecting household applications. By eliminating the household application process and streamlining meal counting and claiming procedures through the Community Eligibility Provision, local educational agencies may substantially reduce administrative burden related to operating the National School Lunch and School Breakfast Programs. This rule codifies many requirements that were implemented through policy guidance following enactment of the Healthy, Hunger-Free Kids Act of 2010, as well as provisions of the proposed rule. These requirements will result in consistent, national implementation of the Community Eligibility Provision.

  19. 10 CFR 420.15 - Minimum criteria for required program activities for plans.

    Science.gov (United States)

    2010-01-01

    ... leased by the United States, buildings whose peak design rate of energy usage for all purposes is less...-rise residential buildings, be no less stringent than the Model Energy Code, 1993, and should be..., State, and Federal energy efficiency, renewable energy and alternative transportation fuel programs...

  20. 40 CFR 745.325 - Lead-based paint activities: State and Tribal program requirements.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Lead-based paint activities: State and... AGENCY (CONTINUED) TOXIC SUBSTANCES CONTROL ACT LEAD-BASED PAINT POISONING PREVENTION IN CERTAIN RESIDENTIAL STRUCTURES State and Indian Tribal Programs § 745.325 Lead-based paint activities: State and...

  1. The Application of Programmed Instruction in Fulfilling the Physiology Course Requirements

    Science.gov (United States)

    Stanisavljevic, Jelena; Djuric, Dragan

    2013-01-01

    The aim of this study is to compare the effectiveness of models of programmed instruction and conventional (informative-illustrative) expository teaching in terms of fulfilling the aims of the course "Human anatomy and physiology" which is included in the physiology programme and designed for undergraduate students majoring in biology…

  2. Shallow Roots Require Constant Watering: The Challenge of Sustained Impact in Educational Programs

    Science.gov (United States)

    Rosen, Yigal; Perkins, David

    2013-01-01

    Socially-oriented educational programs often face societal barriers. Peace education in a region of prolonged conflict faces a negative socio-political environment that works against its effects. The media, leadership, educational system and other societal institutions continue to express a culture of conflict. Recent studies show that the effects…

  3. Reassessing the Skills Required of Graduates of an Information Systems Program: An Updated Analysis

    Science.gov (United States)

    Legier, John; Woodward, Belle; Martin, Nancy

    2013-01-01

    The study involves an updated analysis of the job characteristics of information systems graduates based on the status of the job market as well as the perceptions of 72 graduates from an information systems program of a Midwestern university. Approximately one-third of the graduates were working in positions related to technical support.…

  4. Integrated Sociology Program Assessment: Inclusion of a Senior Portfolio Graduation Requirement

    Science.gov (United States)

    Crockett, Jason L.; Fu, Albert S.; Greenwood, Joleen L.; John, Mauricia A.

    2018-01-01

    This article presents information about the planning, implementation, and findings of an assessment-based student portfolio designed by the faculty of a sociology program at Kutztown University of Pennsylvania, a midsized public regional liberal arts institution. First, we briefly present the rationale for implementing a portfolio system and the…

  5. 75 FR 58203 - Medicare, Medicaid, and Children's Health Insurance Programs; Additional Screening Requirements...

    Science.gov (United States)

    2010-09-23

    ... Practitioner Data Bank (NPDB), accreditation status of institutional providers and suppliers with national... Provider Identifier (NPI), the National Practitioner Data Bank (NPDB) licensure, an OIG exclusion, taxpayer... Medicaid program or CHIP. Section 424.502 contains additional definitions that apply to these and other...

  6. 78 FR 38989 - New Policies and Procedural Requirements for Electronic Submission of State Plans, and Program...

    Science.gov (United States)

    2013-06-28

    ... Expenditures and Obligations. Refugee Social Services Form SF-425: Federal Financial Report (FFR). Refugee... Enforcement--Tribes...... Form SF-425: Federal Financial Report (FFR). Child Welfare Social Services Form SF...). Native Employment Works Program........ Form SF-425: Federal Financial Report (FFR). Promoting Safe and...

  7. 76 FR 50129 - Protocol Gas Verification Program and Minimum Competency Requirements for Air Emission Testing...

    Science.gov (United States)

    2011-08-12

    ..., disproportionately high and adverse human health or environmental effects of their programs, policies, and activities... rule will not have disproportionately high and adverse human health or environmental effects on... October 11, 2011. List of Subjects in 40 CFR Part 75 Environmental protection, Acid rain, Administrative...

  8. Characterizing irrigation water requirements for rice production from the Arkansas Rice Research Verification Program

    Science.gov (United States)

    This study investigated rice irrigation water use in the University of Arkansas Rice Research Verification Program between the years of 2003 and 2011. Irrigation water use averaged 747 mm (29.4 inches) over the nine years. A significant 40% water savings was reported for rice grown under a zero gr...

  9. 77 FR 58830 - State Program Requirements; Application To Administer Partial National Pollutant Discharge...

    Science.gov (United States)

    2012-09-24

    ...PDES) program pursuant to Section 402(b) of the Clean Water Act (CWA or ``the Act''). ODAFF seeks... holidays, at EPA Region 6, 1445 Ross Ave., Dallas, Texas 75202. A copy of ODAFF's application is available online at the EPA Region 6 Web page http://www.epa.gov/region6/water/npdes/ok-daff/index.html . A paper...

  10. 50 CFR 648.60 - Sea scallop area access program requirements.

    Science.gov (United States)

    2010-10-01

    ... Management Measures for the Atlantic Sea Scallop Fishery § 648.60 Sea scallop area access program....83(a)(1), and the additional restrictions for Atlantic cod, haddock, and yellowtail flounder... (d)(4). (A) Atlantic cod. Such vessel may bring onboard and possess only up to 100 lb (45.4 kg) of...

  11. 77 FR 8148 - Anti-Money Laundering Program and Suspicious Activity Report Filing Requirements for Residential...

    Science.gov (United States)

    2012-02-14

    ... incorporation or tax laws. An exception for sole proprietorships likely would perpetuate, to some degree, the... reports that the Secretary determines ``have a high degree of usefulness in criminal, tax, or regulatory... consequences that undermine the effectiveness of a comprehensive, risk-based AML and SAR program regime. Such...

  12. 77 FR 31618 - Medicaid Program; Announcement of Requirements and Registration for CMS Provider Screening...

    Science.gov (United States)

    2012-05-29

    ... identity and prior history of problems with Medicaid/CHIP or Medicare programs. d. Capability to identify... would be capable of risk scoring, credentialing validation, identity authentication, and sanction checks... estimate that the total prize amount for the competitions conducted as part of this Challenge will fall...

  13. Personal radiation detector at a high technology readiness level that satisfies DARPA's SN-13-47 and SIGMA program requirements

    Science.gov (United States)

    Ginzburg, D.; Knafo, Y.; Manor, A.; Seif, R.; Ghelman, M.; Ellenbogen, M.; Pushkarsky, V.; Ifergan, Y.; Semyonov, N.; Wengrowicz, U.; Mazor, T.; Kadmon, Y.; Cohen, Y.; Osovizky, A.

    2015-06-01

    There is a need to develop new personal radiation detector (PRD) technologies that can be mass produced. On August 2013, DARPA released a request for information (RFI) seeking innovative radiation detection technologies. In addition, on December 2013, a Broad Agency Announcement (BAA) for the SIGMA program was released. The RFI requirements focused on a sensor that should possess three main properties: low cost, high compactness and radioisotope identification capabilities. The identification performances should facilitate the detection of a hidden threat, ranging from special nuclear materials (SNM) to commonly used radiological sources. Subsequently, the BAA presented the specific requirements at an instrument level and provided a comparison between the current market status (state-of-the-art) and the SIGMA program objectives. This work presents an optional alternative for both the detection technology (sensor with communication output and without user interface) for DARPA's initial RFI and for the PRD required by the SIGMA program. A broad discussion is dedicated to the method proposed to fulfill the program objectives and to the selected alternative that is based on the PDS-GO design and technology. The PDS-GO is the first commercially available PRD that is based on a scintillation crystal optically coupled with a silicon photomultiplier (SiPM), a solid-state light sensor. This work presents the current performance of the instrument and possible future upgrades based on recent technological improvements in the SiPM design. The approach of utilizing the SiPM with a commonly available CsI(Tl) crystal is the key for achieving the program objectives. This approach provides the appropriate performance, low cost, mass production and small dimensions; however, it requires a creative approach to overcome the obstacles of the solid-state detector dark current (noise) and gain stabilization over a wide temperature range. Based on the presented results, we presume that

  14. Genomic selection needs to be carefully assessed to meet specific requirements in livestock breeding programs

    Science.gov (United States)

    Jonas, Elisabeth; de Koning, Dirk-Jan

    2015-01-01

    Genomic selection is a promising development in agriculture, aiming improved production by exploiting molecular genetic markers to design novel breeding programs and to develop new markers-based models for genetic evaluation. It opens opportunities for research, as novel algorithms and lab methodologies are developed. Genomic selection can be applied in many breeds and species. Further research on the implementation of genomic selection (GS) in breeding programs is highly desirable not only for the common good, but also the private sector (breeding companies). It has been projected that this approach will improve selection routines, especially in species with long reproduction cycles, late or sex-limited or expensive trait recording and for complex traits. The task of integrating GS into existing breeding programs is, however, not straightforward. Despite successful integration into breeding programs for dairy cattle, it has yet to be shown how much emphasis can be given to the genomic information and how much additional phenotypic information is needed from new selection candidates. Genomic selection is already part of future planning in many breeding companies of pigs and beef cattle among others, but further research is needed to fully estimate how effective the use of genomic information will be for the prediction of the performance of future breeding stock. Genomic prediction of production in crossbreeding and across-breed schemes, costs and choice of individuals for genotyping are reasons for a reluctance to fully rely on genomic information for selection decisions. Breeding objectives are highly dependent on the industry and the additional gain when using genomic information has to be considered carefully. This review synthesizes some of the suggested approaches in selected livestock species including cattle, pig, chicken, and fish. It outlines tasks to help understanding possible consequences when applying genomic information in breeding scenarios. PMID

  15. Weapon System Requirements: Detailed Systems Engineering Prior to Product Development Positions Programs for Success

    Science.gov (United States)

    2016-11-01

    report on systems engineering status of each major acquisition program in the department’s annual budget request. What GAO Found GAO’s analysis of...more detailed descriptions of the system design are established in what systems engineering literature refers to as configuration baselines. Within...does not necessarily mean that problems are unavoidable. Rather, the ensuing systems engineering effort, if timely and sufficiently vigorous, can

  16. Genomic selection needs to be carefully assessed to meet specific requirements in livestock breeding programs

    Directory of Open Access Journals (Sweden)

    Elisabeth eJonas

    2015-02-01

    Full Text Available Genomic selection is a promising development in agriculture, aiming improved production by exploiting molecular genetic markers to design novel breeding programs and to develop new markers-based models for genetic evaluation. It opens opportunities for research, as novel algorithms and lab methodologies are developed. Genomic selection can be applied in many breeds and species. Further research on the implementation of genomic selection in breeding programs is highly desirable not only for the common good, but also the private sector (breeding companies. It has been projected that this approach will improve selection routines, especially in species with long reproduction cycles, late or sex-limited or expensive trait recording and for complex traits. The task of integrating genomic selection into existing breeding programs is, however, not straightforward. Despite successful integration into breeding programs for dairy cattle, it has yet to be shown how much emphasis can be given to the genomic information and how much additional phenotypic information is needed from new selection candidates. Genomic selection is already part of future planning in many breeding companies of pigs and beef cattle among others, but further research is needed to fully estimate how effective the use of genomic information will be for the prediction of the performance of future breeding stock. Genomic prediction of production in crossbreeding and across-breed schemes, costs and choice of individuals for genotyping are reasons for a reluctance to fully rely on genomic information for selection decisions. Breeding objectives are highly dependent on the industry and the additional gain when using genomic information has to be considered carefully. This review synthesizes some of the suggested approaches in selected livestock species including cattle, pig, chicken and fish. It outlines tasks to help understanding possible consequences when applying genomic information in

  17. ALGEBRA: a computer program that algebraically manipulates finite element output data. [In extended FORTRAN for CDC 7600 or CYBER 76 only

    Energy Technology Data Exchange (ETDEWEB)

    Richgels, M A; Biffle, J H

    1980-09-01

    ALGEBRA is a program that allows the user to process output data from finite-element analysis codes before they are sent to plotting routines. These data take the form of variable values (stress, strain, and velocity components, etc.) on a tape that is both the output tape from the analyses code and the input tape to ALGEBRA. The ALGEBRA code evaluates functions of these data and writes the function values on an output tape that can be used as input to plotting routines. Convenient input format and error detection capabilities aid the user in providing ALGEBRA with the functions to be evaluated. 1 figure.

  18. 77 FR 35953 - Arts in Education National Program; Final Priority, Requirements, Definitions, and Selection...

    Science.gov (United States)

    2012-06-15

    ... AGENCY: Office of Innovation and Improvement, Department of Education. ACTION: Notice. SUMMARY: The Assistant Deputy Secretary for Innovation and Improvement announces the final priority, requirements... importance of sequential, standards-based teaching that is unique to music education. The commenter added...

  19. 78 FR 72600 - Proposed Priorities, Requirements, and Definitions-Charter Schools Program (CSP) Grants for...

    Science.gov (United States)

    2013-12-03

    ...) Grants for National Leadership Activities AGENCY: Office of Innovation and Improvement, Department of... Assistant Deputy Secretary for Innovation and Improvement proposes priorities, requirements, and definitions...-career-ready standards. Moreover, it is of great importance to ensure equitable access to and use of...

  20. 42 CFR 424.510 - Requirements for enrolling in the Medicare program.

    Science.gov (United States)

    2010-10-01

    ... and suppliers seeking accreditation from a CMS-approved accreditation organization as specified in... supplier type. (ii) Submission of all documentation required by CMS under this or other statutory or... location, social security number (SSN), tax identification number (TIN), National Provider Identifier (NPI...

  1. 75 FR 33391 - Amendments to the Protocol Gas Verification Program and Minimum Competency Requirements for Air...

    Science.gov (United States)

    2010-06-11

    ... testing (formerly air emission testing body requirements) to improve the accuracy of emissions data. EPA... left out of the January 24, 2008 final rule, and clarifying the language and applicability of certain..., which means EPA will not know your identity or contact information unless you provide it in the body of...

  2. 76 FR 17287 - Protocol Gas Verification Program and Minimum Competency Requirements for Air Emission Testing

    Science.gov (United States)

    2011-03-28

    ... emission testing body requirements) to improve the accuracy of emissions data. EPA is also amending other... rule, adding two new definitions, revising certain compliance dates, and clarifying the language and...-Compliant Air Emission Testing Body (AETB) Names C. Other Amendments 1. Compliance Dates for Units Adding...

  3. 40 CFR 403.8 - Pretreatment Program Requirements: Development and Implementation by POTW.

    Science.gov (United States)

    2010-07-01

    ... AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS GENERAL PRE-TREAT-MENT REGULATIONS FOR EXIST-ING AND... applicable civil and criminal penalties for violation of Pretreatment Standards and requirements, and any... authority to seek or assess civil or criminal penalties in at least the amount of $1,000 a day for each...

  4. 49 CFR Appendix to Part 380 - LCV Driver Training Programs, Required Knowledge and Skills

    Science.gov (United States)

    2010-10-01

    ..., and basic health and wellness issues. Emphasis must be placed upon topics essential to physical and mental health maintenance, including (1) diet, (2) exercise, (3) avoidance of alcohol and drug abuse, and... must address the importance of and requirements for planning routes and trips. This must include...

  5. Inter-Service/Agency Automated Message Processing Exchange Program. Functional Requirements Description and Interface Control Document.

    Science.gov (United States)

    1983-11-01

    function. The SSN must be all numbers or the message is rejected. The SSN also is used as the End of Message CEOM ) validation number in message...n contain the ; 1 2 4 1Z -; d 6? char: • Kequireo Fie ncludinq s c s: Lines FORMAT LINE 16 - CEOM ) - Required field The i e n

  6. 78 FR 31283 - Medicare Program; Medical Loss Ratio Requirements for the Medicare Advantage and the Medicare...

    Science.gov (United States)

    2013-05-23

    ... potential to bid below the LIS benchmark and receive auto-enrollment for its non- enhanced PDPs. Comment: A... termination. MA organizations and Part D sponsors will be required to submit data to CMS that will allow... for bidding. Many commenters agreed with reporting at the contract level as proposed. Response: We...

  7. 78 FR 12427 - Medicare Program; Medical Loss Ratio Requirements for the Medicare Advantage and the Medicare...

    Science.gov (United States)

    2013-02-22

    ... insurance issuers must report an MLR and related supporting data by state and market (individual, small... than MA-PDs for MLR purposes. Cost HMOs/CMPs and employers/unions offering HCPPs bid on Part D and receive Part D payments based on their bid. Thus, we propose to require remittances, suspend enrollment...

  8. Determining Consistency of Tillage Direction with Soil Erosion Protection Requirements as The Element of Decision-Making Process in Planning and Applying Land Consolidation

    Science.gov (United States)

    Bozek, Piotr; Janus, Jaroslaw; Taszakowski, Jaroslaw; Glowacka, Agnieszka

    2016-10-01

    Water erosion is one of the factors which have negative effect on soil productivity. It often leads to irreversible soil degradation, making soil worthless for agricultural activities. One way of preventing water erosion is making the direction of cultivation perpendicular to the direction of rainwater run-off. Matching the direction with the shape of parcels boundaries in small and extended ones is often possible only through changes in the configuration of property boundaries, which is possible only in the process of land consolidation. The article presents methodology of qualifying the areas for changes in boundaries configuration and cultivation direction in view of existing erosion risk. A computation process was suggested that uses, among others, LIDAR data to model the terrain shape precisely as well as cadastral data that defines the geometry of parcels and, resulting from it, the direction of cultivation and form of use. The suggested process includes also the information on the texture of soil upper horizons from soil agricultural maps. The RUSLE erosion model was applied and the computation process took place in ArcGIS environment with the use of dedicated algorithms suggested and implemented to solve the formulated problem. Computations were conducted for test area of several hundred hectares which was characterized by vast diversity of soil types and landforms. The results prove the usefulness of the suggested method as an element of systems that support decision-making processes used in the stage of determining objects chosen for the realization of consolidating processes (including local consolidation, which covers only chosen fragment of a village). They can also be used in the stage of completing detailed plans of parcels distribution in land consolidation process. The importance of the method is particularly seen in the analysis of areas where land fragmentation indices are unfavourable. Especially in these cases, without the reorganization of

  9. The First Development of Human Factors Engineering Requirements for Application to Ground Task Design for a NASA Flight Program

    Science.gov (United States)

    Dischinger, H. Charles, Jr.; Stambolian, Damon B.; Miller, Darcy H.

    2008-01-01

    The National Aeronautics and Space Administration has long applied standards-derived human engineering requirements to the development of hardware and software for use by astronauts while in flight. The most important source of these requirements has been NASA-STD-3000. While there have been several ground systems human engineering requirements documents, none has been applicable to the flight system as handled at NASA's launch facility at Kennedy Space Center. At the time of the development of previous human launch systems, there were other considerations that were deemed more important than developing worksites for ground crews; e.g., hardware development schedule and vehicle performance. However, experience with these systems has shown that failure to design for ground tasks has resulted in launch schedule delays, ground operations that are more costly than they might be, and threats to flight safety. As the Agency begins the development of new systems to return humans to the moon, the new Constellation Program is addressing this issue with a new set of human engineering requirements. Among these requirements is a subset that will apply to the design of the flight components and that is intended to assure ground crew success in vehicle assembly and maintenance tasks. These requirements address worksite design for usability and for ground crew safety.

  10. ILS Element E1 Maintenance Planning: Distribution Program and User’s Manual. Version 1.0

    Science.gov (United States)

    1991-04-01

    For a single digit , enter a blank space or zero to the left of the digit . The program accepts only actual dates. If an incorrect date is entered...Documentation for Comoleteness and Firmaness E1.2-1 What stage of develooment- are you in?: "o Concept Exploration "o Development and Validation "o Full Scale

  11. Joint Program on Rapid Prototyping. RaPIER (Rapid Prototyping to Investigate End-User Requirements).

    Science.gov (United States)

    1985-03-28

    for reuse. The Ada langauge contains a rich set of features that support reusability. Some of the most important ones are: o packages, o separate...telephone consultants for RaPIER at least through the fifth year of this project. Beyond that, the Computer Sciences Center will need to transfer...motivated to exploit them, can/will become a RaPIER skilled user; 6. deals with requirements; T . deals with new products; 8. is part of the contractor’s

  12. Participation in Older Adult Physical Activity Programs and Risk for Falls Requiring Medical Care, Washington State, 2005–2011

    Science.gov (United States)

    Rosenberg, Dori E.; Phelan, Elizabeth A.; Fitzpatrick, Annette L.

    2015-01-01

    Introduction Physical activity is known to prevent falls; however, use of widely available exercise programs for older adults, including EnhanceFitness and Silver Sneakers, has not been examined in relation to effects on falls among program participants. We aimed to determine whether participation in EnhanceFitness or Silver Sneakers is associated with a reduced risk of falls resulting in medical care. Methods A retrospective cohort study examined a demographically representative sample from a Washington State integrated health system. Health plan members aged 65 or older, including 2,095 EnhanceFitness users, 13,576 Silver Sneakers users, and 55,127 nonusers from 2005 through 2011, were classified as consistent users (used a program ≥2 times in all years they were enrolled in the health plan during the study period); intermittent users (used a program ≥2 times in 1 or more years enrolled but not all years), or nonusers of EnhanceFitness or Silver Sneakers. The main outcome was measured as time-to-first-fall requiring inpatient or out-of-hospital medical treatment based on the International Classification of Diseases, 9th Revision, Clinical Modification, Sixth Edition and E-codes. Results In fully adjusted Cox proportional hazards models, consistent (hazard ratio [HR], 0.74; 95% confidence interval [CI], 0.63–0.88) and intermittent (HR, 0.87; 95% CI, 0.8–0.94) EnhanceFitness participation were both associated with a reduced risk of falls resulting in medical care. Intermittent Silver Sneakers participation showed a reduced risk (HR, 0.93; 95% CI, 0.90–0.97). Conclusion Participation in widely available community-based exercise programs geared toward older adults (but not specific to fall prevention) reduced the risk of medical falls. Structured programs that include balance and strength exercise, as EnhanceFitness does, may be effective in reducing fall risk. PMID:26068411

  13. Participation in Older Adult Physical Activity Programs and Risk for Falls Requiring Medical Care, Washington State, 2005-2011.

    Science.gov (United States)

    Greenwood-Hickman, Mikael Anne; Rosenberg, Dori E; Phelan, Elizabeth A; Fitzpatrick, Annette L

    2015-06-11

    Physical activity is known to prevent falls; however, use of widely available exercise programs for older adults, including EnhanceFitness and Silver Sneakers, has not been examined in relation to effects on falls among program participants. We aimed to determine whether participation in EnhanceFitness or Silver Sneakers is associated with a reduced risk of falls resulting in medical care. A retrospective cohort study examined a demographically representative sample from a Washington State integrated health system. Health plan members aged 65 or older, including 2,095 EnhanceFitness users, 13,576 Silver Sneakers users, and 55,127 nonusers from 2005 through 2011, were classified as consistent users (used a program ≥2 times in all years they were enrolled in the health plan during the study period); intermittent users (used a program ≥2 times in 1 or more years enrolled but not all years), or nonusers of EnhanceFitness or Silver Sneakers. The main outcome was measured as time-to-first-fall requiring inpatient or out-of-hospital medical treatment based on the International Classification of Diseases, 9th Revision, Clinical Modification, Sixth Edition and E-codes. In fully adjusted Cox proportional hazards models, consistent (hazard ratio [HR], 0.74; 95% confidence interval [CI], 0.63-0.88) and intermittent (HR, 0.87; 95% CI, 0.8-0.94) EnhanceFitness participation were both associated with a reduced risk of falls resulting in medical care. Intermittent Silver Sneakers participation showed a reduced risk (HR, 0.93; 95% CI, 0.90-0.97). Participation in widely available community-based exercise programs geared toward older adults (but not specific to fall prevention) reduced the risk of medical falls. Structured programs that include balance and strength exercise, as EnhanceFitness does, may be effective in reducing fall risk.

  14. VIBA-Lab 3.0: Computer program for simulation and semi-quantitative analysis of PIXE and RBS spectra and 2D elemental maps

    Science.gov (United States)

    Orlić, Ivica; Mekterović, Darko; Mekterović, Igor; Ivošević, Tatjana

    2015-11-01

    VIBA-Lab is a computer program originally developed by the author and co-workers at the National University of Singapore (NUS) as an interactive software package for simulation of Particle Induced X-ray Emission and Rutherford Backscattering Spectra. The original program is redeveloped to a VIBA-Lab 3.0 in which the user can perform semi-quantitative analysis by comparing simulated and measured spectra as well as simulate 2D elemental maps for a given 3D sample composition. The latest version has a new and more versatile user interface. It also has the latest data set of fundamental parameters such as Coster-Kronig transition rates, fluorescence yields, mass absorption coefficients and ionization cross sections for K and L lines in a wider energy range than the original program. Our short-term plan is to introduce routine for quantitative analysis for multiple PIXE and XRF excitations. VIBA-Lab is an excellent teaching tool for students and researchers in using PIXE and RBS techniques. At the same time the program helps when planning an experiment and when optimizing experimental parameters such as incident ions, their energy, detector specifications, filters, geometry, etc. By "running" a virtual experiment the user can test various scenarios until the optimal PIXE and BS spectra are obtained and in this way save a lot of expensive machine time.

  15. AN/TTC-39 Program: A Case Study of Manpower, Personnel and Training Requirements Determination

    Science.gov (United States)

    1984-01-01

    concepts. The Central Processor Group ( CPG ), used in the AN/TTC-39 and AN/TYC-39, is basically the same as that used in the TACFIRE and AN/TSO-73...Insertion Demonstration A Fault Insertion Demonstration ( FID ) was performed on two AN/TYC-39 Message Switches at FT Huachuca, AZ from 4 May to 21 July...criterion. However, the overall median repair time was 35 minutes which approaches the user established requirement. An assessment of training during the FID

  16. The Air Force Global Reach Laydown (GRL): Using the Estimating Supplies Program to Validate Clinical Requirements

    Science.gov (United States)

    2006-01-11

    Call Oxygen Admin 100 Adhesive tape surgical 198X2” white hypoallergenic 6S - Needle Thoracostomy 25 166 GRL Preventive...required tasks not previously satisfied accounted for $945.09. Other modest increases in items like bed pads and self- adhesive thermometers accounted for...PG 1 0 0.045 0.002 $2.28 0 0 $0.00 G 6508014360607 LIPSTICK ANTICHAP COLD OR HOT CLIMATE SPF 15 4.4GM STICK 144/PG PG 1 0 0.088 0.001 $2.99 0 0

  17. Striking a Balance between Program Requirements and GT Principles: Writing a compromised GT proposal

    OpenAIRE

    Sherry L. Xie, Ph.D. Candidate

    2009-01-01

    Glaser’s term “compromised GT proposal” (2001, p.114) refers to the type of Grounded Theory (GT) proposal that is written in order to conform to the requirements of a standardized qualitative research proposal. A GT proposal needs only to supply information on the area of interest, the data source and a statement of method to the effect that the researcher begin to collect, code and analyse the data and let the theory emerge. Thus, the proposal may only occupy “a page or two” (Glaser, 2001, p...

  18. Department of Energy Environmental Management cost infrastructure development program: Cost analysis requirements

    Energy Technology Data Exchange (ETDEWEB)

    Custer, W.R. Jr.; Messick, C.D.

    1996-03-31

    This report was prepared to support development of the Department of Energy Environmental Management cost infrastructure -- a new capability to independently estimate and analyze costs. Currently, the cost data are reported according to a structure that blends level of effort tasks with product and process oriented tasks. Also. the budgetary inputs are developed from prior year funding authorizations and from contractor-developed parametric estimates that have been adjusted to planned funding levels or appropriations. Consequently, it is difficult for headquarters and field-level activities to use actual cost data and technical requirements to independently assess the costs generated and identify trends, potential cost savings from process improvements, and cost reduction strategies.

  19. MANTLE: A finite element program for the thermal-mechanical analysis of mantle convection. A user's manual with examples

    Science.gov (United States)

    Thompson, E.

    1979-01-01

    A finite element computer code for the analysis of mantle convection is described. The coupled equations for creeping viscous flow and heat transfer can be solved for either a transient analysis or steady-state analysis. For transient analyses, either a control volume or a control mass approach can be used. Non-Newtonian fluids with viscosities which have thermal and spacial dependencies can be easily incorporated. All material parameters may be written as function statements by the user or simply specified as constants. A wide range of boundary conditions, both for the thermal analysis and the viscous flow analysis can be specified. For steady-state analyses, elastic strain rates can be included. Although this manual was specifically written for users interested in mantle convection, the code is equally well suited for analysis in a number of other areas including metal forming, glacial flows, and creep of rock and soil.

  20. User’s Guide for the Incremental Construction, Soil-Structure Interaction Program SOILSTRUCT with Far-Field Boundary Elements

    Science.gov (United States)

    1994-03-01

    Unlimited , TIC t’%i ELECTE •m• Y2 5,1, ඦ 5" 23 116 Prepared for Headquarters, U.S. Army Corps of Engineers The contents of this report an not to be...evaluation of soil-structure interaction of earth retaining structures. The initial version of the program was developed by Profesors G. W. Clough and J

  1. Review of important rock mechanics studies required for underground high level nuclear waste repository program

    Energy Technology Data Exchange (ETDEWEB)

    Kwon, S.; Cho, W. J

    2007-01-15

    Disposal concept adapting room and pillar method, which is a confirmed technique in mining and tunnel construction for long time, has advantages at cost, safety, technical feasibility, flexibility, and international cooperation point of views. Then the important rock mechanics principals and in situ and laboratory tests for understanding the behavior of rock, buffer, and backfill as well as their interactions will be reviewed. The accurate understanding of them is important for developing a safe disposal concept and successful operation of underground repository for permanent disposal of radioactive wastes. First of all, In this study, current status of rock mechanics studies for HLW disposal in foreign countries such as Sweden, USA, Canada, Finland, Japan, and France were reviewed. After then the in situ and laboratory tests for site characterization were summarized. Furthermore, rock mechanics studies required during the whole procedure for the disposal project from repository design to the final closure will be reviewed systematically. This study will help for developing a disposal system including site selection, repository design, operation, maintenance, and closure of a repository in deep underground rock. By introducing the required rock mechanics tests at different stages, it would be helpful from the planning stage to the operation stage of a radioactive waste disposal project.

  2. Programmed cell cycle arrest is required for infection of corn plants by the fungus Ustilago maydis.

    Science.gov (United States)

    Castanheira, Sónia; Mielnichuk, Natalia; Pérez-Martín, José

    2014-12-01

    Ustilago maydis is a plant pathogen that requires a specific structure called infective filament to penetrate the plant tissue. Although able to grow, this filament is cell cycle arrested on the plant surface. This cell cycle arrest is released once the filament penetrates the plant tissue. The reasons and mechanisms for this cell cycle arrest are unknown. Here, we have tried to address these questions. We reached three conclusions from our studies. First, the observed cell cycle arrest is the result of the cooperation of at least two distinct mechanisms: one involving the activation of the DNA damage response (DDR) cascade; and the other relying on the transcriptional downregulation of Hsl1, a kinase that modulates the G2/M transition. Second, a sustained cell cycle arrest during the infective filament step is necessary for the virulence in U. maydis, as a strain unable to arrest the cell cycle was severely impaired in its ability to infect corn plants. Third, production of the appressorium, a structure required for plant penetration, is incompatible with an active cell cycle. The inability to infect plants by strains defective in cell cycle arrest seems to be caused by their failure to induce the appressorium formation process. In summary, our findings uncover genetic circuits to arrest the cell cycle during the growth of this fungus on the plant surface, thus allowing the penetration into plant tissue. © 2014. Published by The Company of Biologists Ltd.

  3. The Multi-Disciplinary Graduate Program in Educational Research. Final Report, Part III; Elements of Panel Analysis.

    Science.gov (United States)

    Lazarsfeld, Paul F., Ed.

    Four case studies were used to illustrate application of panel analysis in sociological research. The panel design requires that (a) identical units be reobserved; (b) identical criteria be employed; and (c) initial and subsequent observations be made at the same times for all units and all criteria. Units may be individuals, qroups (such as…

  4. Observational program options and system requirements for the search for extraterrestrial intelligence /SETI/

    Science.gov (United States)

    Billingham, J.; Wolfe, J. H.; Edelson, R. E.; Gulkis, S.; Sadin, S. R.

    1978-01-01

    The possibility that intelligent life may be widespread in the universe is now being investigated. A formula for estimating the number of coexisting communicative civilizations has been developed by Drake. A good way of conducting a search for extraterrestrial intelligence (SETI) is to examine the microwave window of the electromagnetic spectrum for narrow-band signals which such civilizations may be transmitting. Two specific search strategies are described. Both employ existing antennas equipped with sophisticated multichannel spectrum analyzers and pattern recognition devices. The Ames Research Center proposal is a high sensitivity, high-resolution search of nearby promising stars and selected sky areas in the 'water hole' (1400-1727 MHz). The Jet Propulsion Laboratory proposal is for a survey of most of the sky over a significant portion of the free-space microwave window at lower sensitivities and resolutions. The approaches are complementary and both are being pursued. The consummation of these programs could achieve one of the most profound discoveries in the history of human civilization, or at least will show the way to future efforts.

  5. Evaluation of a required statewide interdisciplinary rural health education program: student attitudes, career intents and perceived quality.

    Science.gov (United States)

    Shannon, Claude K; Baker, Helen; Jackson, Jodie; Roy, Abira; Heady, Hilda; Gunel, Erdogan

    2005-11-01

    A shortage of healthcare providers in West Virginia led to the creation of a statewide, community-based program with a required three-month rural experience for most state-sponsored health professions students. Project description: Initiated using funding from the W. K. Kellogg Foundation and expanded using both state funds and Area Health Education Center support, the West Virginia Rural Health Education Partnerships (WVRHEP) program impacts institutions of higher learning, 50 counties, and 332 training sites, and all students in state-funded health professions schools. A longitudinal database has been constructed to study program effects on students' reported attitudes, service orientation, and career intents. Baseline data are collected from medical students, and students in all disciplines provide feedback on rotations and information about career intents, social responsibility, and attitudes towards rural practice. Data indicate an association between perceived quality of the rural experience and increased interest in rural health, social responsibility and confidence in becoming part of the community. Medical students may tend to rate social responsibility higher after completion of the first rural rotation. Students who anticipate practice in smaller towns also tend to rate the quality of the rotation higher, to anticipate careers in primary care, and to acknowledge social responsibility. As WVRHEP program graduates who have completed these surveys enter practice, both personal and community-specific program characteristics may be identified which strengthen interest in rural practice. The predictive validity of intermediate outcomes of attitudes and career intents in forecasting the ultimate outcomes of recruitment and retention may be studied.

  6. Multiple neural oscillators and muscle feedback are required for the intestinal fed state motor program.

    Science.gov (United States)

    Chambers, Jordan D; Bornstein, Joel C; Thomas, Evan A

    2011-05-05

    After a meal, the gastrointestinal tract exhibits a set of behaviours known as the fed state. A major feature of the fed state is a little understood motor pattern known as segmentation, which is essential for digestion and nutrient absorption. Segmentation manifests as rhythmic local constrictions that do not propagate along the intestine. In guinea-pig jejunum in vitro segmentation constrictions occur in short bursts together with other motor patterns in episodes of activity lasting 40-60 s and separated by quiescent episodes lasting 40-200 s. This activity is induced by luminal nutrients and abolished by blocking activity in the enteric nervous system (ENS). We investigated the enteric circuits that regulate segmentation focusing on a central feature of the ENS: a recurrent excitatory network of intrinsic sensory neurons (ISNs) which are characterized by prolonged after-hyperpolarizing potentials (AHPs) following their action potentials. We first examined the effects of depressing AHPs with blockers of the underlying channels (TRAM-34 and clotrimazole) on motor patterns induced in guinea-pig jejunum, in vitro, by luminal decanoic acid. Contractile episode durations increased markedly, but the frequency and number of constrictions within segmenting bursts and quiescent period durations were unaffected. We used these observations to develop a computational model of activity in ISNs, excitatory and inhibitory motor neurons and the muscle. The model predicted that: i) feedback to ISNs from contractions in the circular muscle is required to produce alternating activity and quiescence with the right durations; ii) transmission from ISNs to excitatory motor neurons is via fast excitatory synaptic potentials (EPSPs) and to inhibitory motor neurons via slow EPSPs. We conclude that two rhythm generators regulate segmentation: one drives contractions within segmentation bursts, the other the occurrence of bursts. The latter depends on AHPs in ISNs and feedback to these

  7. Multiple neural oscillators and muscle feedback are required for the intestinal fed state motor program.

    Directory of Open Access Journals (Sweden)

    Jordan D Chambers

    Full Text Available After a meal, the gastrointestinal tract exhibits a set of behaviours known as the fed state. A major feature of the fed state is a little understood motor pattern known as segmentation, which is essential for digestion and nutrient absorption. Segmentation manifests as rhythmic local constrictions that do not propagate along the intestine. In guinea-pig jejunum in vitro segmentation constrictions occur in short bursts together with other motor patterns in episodes of activity lasting 40-60 s and separated by quiescent episodes lasting 40-200 s. This activity is induced by luminal nutrients and abolished by blocking activity in the enteric nervous system (ENS. We investigated the enteric circuits that regulate segmentation focusing on a central feature of the ENS: a recurrent excitatory network of intrinsic sensory neurons (ISNs which are characterized by prolonged after-hyperpolarizing potentials (AHPs following their action potentials. We first examined the effects of depressing AHPs with blockers of the underlying channels (TRAM-34 and clotrimazole on motor patterns induced in guinea-pig jejunum, in vitro, by luminal decanoic acid. Contractile episode durations increased markedly, but the frequency and number of constrictions within segmenting bursts and quiescent period durations were unaffected. We used these observations to develop a computational model of activity in ISNs, excitatory and inhibitory motor neurons and the muscle. The model predicted that: i feedback to ISNs from contractions in the circular muscle is required to produce alternating activity and quiescence with the right durations; ii transmission from ISNs to excitatory motor neurons is via fast excitatory synaptic potentials (EPSPs and to inhibitory motor neurons via slow EPSPs. We conclude that two rhythm generators regulate segmentation: one drives contractions within segmentation bursts, the other the occurrence of bursts. The latter depends on AHPs in ISNs and feedback

  8. A/T gap tolerance in the core sequence and flanking sequence requirements of non-canonical p53 response elements

    Science.gov (United States)

    Cai, Bi-He; Chao, Chung-Faye; Lin, Hwang-Chi; Huang, Hua-Ying; Kannagi, Reiji; Chen, Jang-Yi

    2016-01-01

    The canonical core sequence of the p53 response element, CATG, has a two-base A/T gap. Previously, we found that p53 can also activate a non-canonical four-base A/T gap CATATG core sequence. In this study, we investigated the possible number of A/T bases used by p53 and showed that a six-base A/T gap CATATATG core sequence was the maximum A/T gap in the p53 response element that could be upregulated by p53 and p63. Canonical and non-canonical p53 response elements also have three-base flanking sequences. A/T bases could be substituted by G/C bases, including CACACG and CGTGTG, but not CGCGCG. We found that the SV40 promoter with functional six- and two-base A/T gap core sequences could be activated by TAp63γ and that TAp63γ could upregulate SV40 small and large T antigens expression in COS7 cells. We also found that the distal region of PUMA promoter with functional two six-base A/T gap core sequences could be activated by TAp63γ in 293T cells. These new findings could provide novel rules for the non-canonical p53 family response element and could extend the entire p53 family regulation network. PMID:26823482

  9. Theoretical substantiation of programs of targeted development of coordination abilities of pupils in lessons of physical training with elements of sports games

    Directory of Open Access Journals (Sweden)

    R.I. Boychuk

    2015-01-01

    Full Text Available Purpose : improving the process of teaching students the art of sports games on the lessons of physical education through targeted development of coordination abilities. Material : an analysis of more than 20 references. Results : The results of the theoretical analysis of the feasibility of targeted improvement of coordination abilities of students in learning motor actions. A program for the coordination of training students in physical education lessons with elements of sports games. Identified tools, methods and instructional techniques parenting coordination abilities. The most significant coordination abilities for sports games have the ability to differentiate the motion parameters, response, spatial orientation and coordination of movements. Conclusions : The targeted improvement of coordination abilities of students in physical education and sports training enhances the effectiveness of the process of learning motor actions.

  10. Concentrations of elements in fish fillets, fish muscle plugs, and crayfish from the 2007 Missouri Department of Conservation General Contaminant Monitoring Program

    Science.gov (United States)

    May, Thomas W.; Walther, Michael J.; Brumbaugh, William G.; McKee, Michael J.

    2009-01-01

    This report presents the results of a contaminant monitoring survey conducted annually by the Missouri Department of Conservation to examine the levels of selected elemental contaminants in fish fillets, fish muscle plugs, and crayfish. Fillets of channel catfish (Ictalurus punctatus), bass (Micropterus salmoides, Micropterus dolomieu, Morone chrysops), walleye (Sander vitreus), common carp (Cyprinus carpio), lake sturgeon (Acipenser fulvescens), northern hog sucker (Hypentelium nigricans), and rainbow trout (Oncorhynchus mykiss) were collected from 21 sites as part of the Department's Fish Contaminant Monitoring Program. Long-pincered crayfish (Orconectes longidigitus) were collected from one site to assess trophic transfer of metals to fish. Fish muscle plugs were collected from smallmouth bass (Micropterus dolomieu) at two different locations from one site.

  11. Concentration of elements in whole-body fish, fish fillets, fish muscle plugs, and fish eggs from the 2008 Missouri Department of Conservation General Contaminant Monitoring Program

    Science.gov (United States)

    May, Thomas W.; Walther, Michael J.; Brumbaugh, William G.; McKee, Michael J.

    2009-01-01

    This report presents the results of a contaminant monitoring survey conducted annually by the Missouri Department of Conservation to examine the levels of selected elemental contaminants in whole-body fish, fish fillets, fish muscle plugs, and fish eggs. Whole-body, fillet, or egg samples of catfish (Ictalurus punctatus, Ictalurus furcatus, Pylodictis olivaris), largemouth bass (Micropterus salmoides), walleye (Sander vitreus), crappie (Pomoxis annularis, Pomoxis nigromaculatus), shovelnose sturgeon (Scaphirhynchus platorynchus), northern hog sucker (Hypentelium nigricans), and Missouri saddled darter (Etheostoma tetrazonum) were collected from 23 sites as part of the Missouri Department of Conservation's Fish Contaminant Monitoring Program. Fish dorsal muscle plugs also were collected from walleye (Sander vitreus) at one of the sites.

  12. The CEBAF Element Database

    Energy Technology Data Exchange (ETDEWEB)

    Theodore Larrieu, Christopher Slominski, Michele Joyce

    2011-03-01

    With the inauguration of the CEBAF Element Database (CED) in Fall 2010, Jefferson Lab computer scientists have taken a step toward the eventual goal of a model-driven accelerator. Once fully populated, the database will be the primary repository of information used for everything from generating lattice decks to booting control computers to building controls screens. A requirement influencing the CED design is that it provide access to not only present, but also future and past configurations of the accelerator. To accomplish this, an introspective database schema was designed that allows new elements, types, and properties to be defined on-the-fly with no changes to table structure. Used in conjunction with Oracle Workspace Manager, it allows users to query data from any time in the database history with the same tools used to query the present configuration. Users can also check-out workspaces to use as staging areas for upcoming machine configurations. All Access to the CED is through a well-documented Application Programming Interface (API) that is translated automatically from original C++ source code into native libraries for scripting languages such as perl, php, and TCL making access to the CED easy and ubiquitous.

  13. Requirement-specific use of trace element biogas additives under consideration of the bioavailability; Bedarfsgerechter Einsatz von Spurenelement-Biogasadditiven unter Beruecksichtigung der Bioverfuegbarkeit

    Energy Technology Data Exchange (ETDEWEB)

    Feher, Adam; Fritz, Thomas; Loewen, Achim; Nelles, Michael [HAWK Hochschule fuer Angewandte Wissenschaft und Kunst Hildesheim/Holzminden/Goettingen, Goettingen (Germany). Fachgebiet Nachhaltige Energie- und Umwelttechnik (NEUTec)

    2013-10-01

    A highly efficient utilisation of substrates and operational stability at the same time is essential for the efficiency of a biogas plant. The research project SequEx of HAWK and /SF GmbH investigates the increase of efficiency of biogas plants by targeted use of trace elements taking into account bio-availability. Based on sequential extraction diagrams a method for the determination of bio-availability of macro- and micro-nutrients is developed. Within this context, different trace element compounds are analysed during the fermentation process on their share of bioavailable micro-nutrients as well as their effect on the biological activity of microorganisms. The actual knowledge gap between common practice of nutrients' supply and real impact shall be closed by the knowledge base enhancement of the bio-availability of nutrients. (orig.)

  14. Analysis of connection element classes and locations and of some structural requirements for the mounting of different superstructure types on transport vehicles

    Directory of Open Access Journals (Sweden)

    Zoran Đ. Majkić

    2011-04-01

    Full Text Available The paper presents the basic requirements for transport vehicles. A special request regarding the adaptation of transport vehicles for the transport of various types of cargo was taken into consideration. Superstructures and the situation arising after mounting superstructures on wheeled transport vehicles were analyzed and the following was described: console coupling, stirrups, simplex elastic coupling, two-way elastic and rigid connection elements. Vehicle torsional elasticity is provided by a proper choice of the type of connection between the superstructure and the vehicle chassis. Applying the instructions of vehicle manufacturers for using appropriate connections between the truck superstructure and the vehicle chassis provides positive torsional elasticity of the vehicle. The paper gives the general recommendations of the Volvo, Mercedes and Renault transport vehicle producers for the use of particular connection types of locations as well as structural requirements for the mounting of concrete mixers, tippers and truck tanks on their vehicles. Introduction Achieving a high level of transport effectiveness depends on a number of factors. One of the most important ones is the possibility to increase the payload share in the gross vehicle weight. This share depends on the net vehicle weight, a method of coupling the truck superstructure with the chassis frame as well as on the truck superstructure construction. Realization of this requirement is of significant importance, particularly for large business systems since it results in the reduction of number of necessary vehicles, more economic fleet maintenance and the fleet capacity increase. It is also relatively easy to adapt the vehicle for the transportation of other loads, depending on user's current needs. The adaptation is correctly performed if manufacturer's recommendations are followed during the mounting of the superstructure on the chassis. This paper gives the analysis of the

  15. New common program requirements for the resident physician workforce and the omission of strategic napping: A missed opportunity.

    Science.gov (United States)

    Shnayder, Michelle M; St Onge, Joan E; Caban-Martinez, Alberto J

    2017-09-01

    Napping has known benefits for fatigue mitigation and improved alertness. However the Accreditation Council for Graduate Medical Education (ACGME) New Common Program Requirements recently removed the 16 h work limit for PGY1 residents and removed any suggestions of napping. We utilized a cross-sectional study design to administer a 44-item questionnaire in June 2016 to 858 residents and fellows at one large urban academic medical center. We assessed: 1) resident physician sentiment of work environment supportiveness for napping at work; and 2) agreement with 2011 ACGME guidelines on workweek hour limitations and strategic napping recommendations. While 89% of residents reported access to an on-call room at work, only 20% felt their work environment supported a culture of napping while at work. Over 76% expressed agreement with the 2011 ACGME work-hour restrictions. Strategies to support napping and well-being within the resident physician workforce and organizational setting are warranted. © 2017 Wiley Periodicals, Inc.

  16. Toxic Elements

    DEFF Research Database (Denmark)

    Hajeb, Parvaneh; Shakibazadeh, Shahram; Sloth, Jens Jørgen

    2016-01-01

    Food is considered the main source of toxic element (arsenic, cadmium, lead, and mercury) exposure to humans, and they can cause major public health effects. In this chapter, we discuss the most important sources for toxic element in food and the foodstuffs which are significant contributors...... to human exposure. The occurrence of each element in food classes from different regions is presented. Some of the current toxicological risk assessments on toxic elements, the human health effect of each toxic element, and their contents in the food legislations are presented. An overview of analytical...... techniques and challenges for determination of toxic elements in food is also given....

  17. Perceptions of the 2011 ACGME duty hour requirements among residents in all core programs at a large academic medical center.

    Science.gov (United States)

    Sandefur, Benjamin J; Shewmaker, Diana M; Lohse, Christine M; Rose, Steven H; Colletti, James E

    2017-11-10

    The Accreditation Council for Graduate Medical Education (ACGME) implemented revisions to resident duty hour requirements (DHRs) in 2011 to improve patient safety and resident well-being. Perceptions of DHRs have been reported to vary by training stage and specialty among internal medicine and general surgery residents. The authors explored perceptions of DHRs among all residents at a large academic medical center. The authors administered an anonymous cross-sectional survey about DHRs to residents enrolled in all ACGME-accredited core residency programs at their institution. Residents were categorized as medical and pediatric, surgery, or other. In total, 736 residents representing 24 core specialty residency programs were surveyed. The authors received responses from 495 residents (67%). A majority reported satisfaction (78%) with DHRs and believed DHRs positively affect their training (73%). Residents in surgical specialties and in advanced stages of training were significantly less likely to view DHRs favorably. Most respondents believed fatigue contributes to errors (89%) and DHRs reduce both fatigue (80%) and performance of clinical duties while fatigued (74%). A minority of respondents (37%) believed that DHRs decrease medical errors. This finding may reflect beliefs that handovers contribute more to errors than fatigue (41%). Negative perceived effects included diminished patient familiarity and continuity of care (62%) and diminished clinical educational experiences for residents (41%). A majority of residents reported satisfaction with the 2011 DHRs, although satisfaction was significantly less among residents in surgical specialties and those in advanced stages of training.

  18. Federal Wind Energy Program. Program summary. [USA

    Energy Technology Data Exchange (ETDEWEB)

    None

    1978-01-01

    The objective of the Federal Wind Energy Program is to accelerate the development of reliable and economically viable wind energy systems and enable the earliest possible commercialization of wind power. To achieve this objective for small and large wind systems requires advancing the technology, developing a sound industrial technology base, and addressing the non-technological issues which could deter the use of wind energy. This summary report outlines the projects being supported by the program through FY 1977 toward the achievement of these goals. It also outlines the program's general organization and specific program elements.

  19. Requirements for the Success of the Integration Program of Disabled Students in the Regular Schools from the Perspective of the Teachers of the Learning Resources Rooms

    Science.gov (United States)

    At-Turki, Jihad; Ali ALdmour, Hisham; Al Maitah, Khalil A. R.; ALsarayreh, Mohammad Nayef

    2012-01-01

    The purpose of this study is to identify the requirements for the success of the integration program and to find out the causes of success and to provide optimal services for the students with disabilities in regular schools. The study attempts to answer the following questions: (1) What are the most important requirements of the success of the…

  20. The Drosophila Translational Control Element (TCE is required for high-level transcription of many genes that are specifically expressed in testes.

    Directory of Open Access Journals (Sweden)

    Rebeccah J Katzenberger

    Full Text Available To investigate the importance of core promoter elements for tissue-specific transcription of RNA polymerase II genes, we examined testis-specific transcription in Drosophila melanogaster. Bioinformatic analyses of core promoter sequences from 190 genes that are specifically expressed in testes identified a 10 bp A/T-rich motif that is identical to the translational control element (TCE. The TCE functions in the 5' untranslated region of Mst(3CGP mRNAs to repress translation, and it also functions in a heterologous gene to regulate transcription. We found that among genes with focused initiation patterns, the TCE is significantly enriched in core promoters of genes that are specifically expressed in testes but not in core promoters of genes that are specifically expressed in other tissues. The TCE is variably located in core promoters and is conserved in melanogaster subgroup species, but conservation dramatically drops in more distant species. In transgenic flies, short (300-400 bp genomic regions containing a TCE directed testis-specific transcription of a reporter gene. Mutation of the TCE significantly reduced but did not abolish reporter gene transcription indicating that the TCE is important but not essential for transcription activation. Finally, mutation of testis-specific TFIID (tTFIID subunits significantly reduced the transcription of a subset of endogenous TCE-containing but not TCE-lacking genes, suggesting that tTFIID activity is limited to TCE-containing genes but that tTFIID is not an obligatory regulator of TCE-containing genes. Thus, the TCE is a core promoter element in a subset of genes that are specifically expressed in testes. Furthermore, the TCE regulates transcription in the context of short genomic regions, from variable locations in the core promoter, and both dependently and independently of tTFIID. These findings set the stage for determining the mechanism by which the TCE regulates testis-specific transcription and

  1. Perioperative Temperature Measurement Considerations Relevant to Reporting Requirements for National Quality Programs Using Data From Anesthesia Information Management Systems.

    Science.gov (United States)

    Epstein, Richard H; Dexter, Franklin; Hofer, Ira S; Rodriguez, Luis I; Schwenk, Eric S; Maga, Joni M; Hindman, Bradley J

    2017-06-08

    Perioperative hypothermia may increase the incidences of wound infection, blood loss, transfusion, and cardiac morbidity. U.S. national quality programs for perioperative normothermia specify the presence of at least 1 "body temperature" ≥35.5°C during the interval from 30 minutes before to 15 minutes after the anesthesia end time. Using data from 4 academic hospitals, we evaluated timing and measurement considerations relevant to the current requirements to guide hospitals wishing to report perioperative temperature measures using electronic data sources. Anesthesia information management system databases from 4 hospitals were queried to obtain intraoperative temperatures and intervals to the anesthesia end time from discontinuation of temperature monitoring, end of surgery, and extubation. Inclusion criteria included age >16 years, use of a tracheal tube or supraglottic airway, and case duration ≥60 minutes. The end-of-case temperature was determined as the maximum intraoperative temperature recorded within 30 minutes before the anesthesia end time (ie, the temperature that would be used for reporting purposes). The fractions of cases with intervals >30 minutes between the last intraoperative temperature and the anesthesia end time were determined. Among the hospitals, averages (binned by quarters) of 34.5% to 59.5% of cases had intraoperative temperature monitoring discontinued >30 minutes before the anesthesia end time. Even if temperature measurement had been continued until extubation, averages of 5.9% to 20.8% of cases would have exceeded the allowed 30-minute window. Averages of 8.9% to 21.3% of cases had end-of-case intraoperative temperatures <35.5°C (ie, a quality measure failure). Because of timing considerations, a substantial fraction of cases would have been ineligible to use the end-of-case intraoperative temperature for national quality program reporting. Thus, retrieval of postanesthesia care unit temperatures would have been necessary. A

  2. SNL/CA Environmental Management System Program Manual.

    Energy Technology Data Exchange (ETDEWEB)

    Larsen, Barbara L.

    2007-04-01

    The Sandia National Laboratories, California (SNL/CA) Environmental Management System (EMS) Program Manual documents the elements of the site EMS Program. The SNL/CA EMS Program conforms to the International Standard on Environmental Management Systems, ISO 14001:2004. Elements of the ISO standard overlap with those of Department of Energy (DOE) Order 450.1, thus SNL/CA's EMS program also meets the DOE requirements.

  3. Army Acquisition and Contracting Personnel Requirements: How are the Army’s Current Recruitment, Development and Retention Programs Meeting Current and Future Personnel Requirements?

    Science.gov (United States)

    2011-09-01

    execution. Organizations provided responses they have or are evaluating schedule flexibility, telework policy, and voluntary civilian fitness. Engaging...alternative work schedules, implementing ACC Telework policy, relocation incentives, and management placing special emphasis on the importance of...MICC G-1 established a voluntary civilian fitness program, embraced alternative work schedules, and implemented ACC Telework policy. 103

  4. Waste Isolation Safety Assessment Program. A brief description of the three-dimensional finite element ground-water flow model adapted for waste isolation safety assessments

    Energy Technology Data Exchange (ETDEWEB)

    Cole, C.R.; Gupta, S.K.

    1979-08-01

    Four levels of hydrologic models have been categorized to handle varying complexities and degrees of available input parameters. The first level is for the simplest one-dimensional models having analytical solutions; the second level includes idealized analytic or hybrid analytic models for single aquifer systems with scanty input data; the third level deals with more complex single or quasi-multilayered systems; and the fourth level is for complex multilayered systems. The three-dimensional finite element ground-water model described in this report falls under the fourth level of hydrologic models. This model is capable of simulating single-layered systems having variable thickness or multilayered systems where not only thickness can be varied, but the number of layers can be changed to agree with the vertical geologic section. Supporting programs have been developed to plot grid values, contour maps and three-dimensional graphics of the input data used in simulation as well as the results obtained. At present, the model considers only confined aquifers. The capabilities of the model were demonstrated by using a test case consisting of the multilayered ground-water system beneath Long Island, New York.

  5. Concentrations of elements in fish fillets, fish muscle plugs, and crayfish from the 2011 Missouri Department of Conservation general contaminant monitoring program

    Science.gov (United States)

    May, Thomas W.; Walther, Michael J.; Brumbaugh, William G.; McKee, Michael J.

    2013-01-01

    This report presents the results of a contaminant monitoring survey conducted annually by the Missouri Department of Conservation to examine the levels of selected elemental contaminants in fish fillets, fish muscle plugs, and crayfish. Fillet samples of yellow bullhead (Ameiurus natalis), golden redhorse (Moxostoma erythrurum), longear sunfish (Lepomis megalotis), and channel catfish (Ictalurus punctatus) were collected from six sites as part of the Missouri Department of Conservation’s Fish Contaminant Monitoring Program. Fish dorsal muscle plugs were collected from largemouth bass (Micropterus salmoides) at eight of the sites, and crayfish from two sites. Following preparation and analysis of the samples, highlights of the data were as follows: cadmium and lead residues were most elevated in crayfish tissue samples from the Big River at Cherokee Landing, with 1 to 8 micrograms per gram dry weight and 22 to 45 micrograms per gram dry weight, respectively. Some dorsal muscle plugs from largemouth bass collected from Clearwater Lake, Lake St. Louis, Noblett Lake, Hazel Creek Lake, and Harrison County Lake contained mercury residues (1.7 to 4.7 micrograms per gram dry weight) that exceeded the U.S. Environmental Protection Agency Water Quality Criterion of 1.5 micrograms per gram dry weight of fish tissue (equivalent to 0.30 micrograms per gram wet weight).

  6. Managing System of Systems Requirements with a Requirements Screening Group

    Energy Technology Data Exchange (ETDEWEB)

    Ronald R. Barden

    2012-07-01

    Figuring out an effective and efficient way to manage not only your Requirement’s Baseline, but also the development of all your individual requirements during a Program’s/Project’s Conceptual and Development Life Cycle Stages can be both daunting and difficult. This is especially so when you are dealing with a complex and large System of Systems (SoS) Program with potentially thousands and thousands of Top Level Requirements as well as an equal number of lower level System, Subsystem and Configuration Item requirements that need to be managed. This task is made even more overwhelming when you have to add in integration with multiple requirements’ development teams (e.g., Integrated Product Development Teams (IPTs)) and/or numerous System/Subsystem Design Teams. One solution for tackling this difficult activity on a recent large System of Systems Program was to develop and make use of a Requirements Screening Group (RSG). This group is essentially a Team made up of co-chairs from the various Stakeholders with an interest in the Program of record that are enabled and accountable for Requirements Development on the Program/Project. The RSG co-chairs, often with the help of individual support team, work together as a Program Board to monitor, make decisions on, and provide guidance on all Requirements Development activities during the Conceptual and Development Life Cycle Stages of a Program/Project. In addition, the RSG can establish and maintain the Requirements Baseline, monitor and enforce requirements traceability across the entire Program, and work with other elements of the Program/Project to ensure integration and coordination.

  7. Site investigation Forsmark. Inventory of requirements, basic data and program for geotechnical investigations; Platsundersoekning Forsmark. Behovsinventering, underlag och program foer geotekniska undersoekningar

    Energy Technology Data Exchange (ETDEWEB)

    Moeren, Lena; Nystroem, Birgitta [SwedPower AB, Stockholm (Sweden)

    2006-03-15

    As part of the site investigation for a deep repository in Forsmark, SwedPower has conducted an assessment of the ground conditions within the area where surface facilities for the repository are planned. The assessment is based on previously performed seismic investigations and information from percussion- and core-drilled boreholes. In addition, a field inventory of soil types in the area of interest was performed. A test pit in the area was also investigated with respect to soil conditions. A bedrock level map (terrain model) based on the available data in the investigated area was developed. The ground surface within the investigated area is rather flat but the depth to the much more undulating bedrock varies between 0-9 m. Outcrops and areas with shallow soil cover occur mainly in the western and northwestern part of the area, but to lesser extent also in the central parts. The largest soil depth is found underneath the pond situated at the central part of the area. Sandy till is the dominating soil type, but there are locations were the till is overlain by peat and clay. The main part of the area is covered by blocky, sandy till near the surface and siltier till towards depth. In some locations there are small marshes, underlain by sedimentary soil. Areas with clay lenses have also been detected. In general, ground conditions in the area are considered to be favourable for foundation of the planned surface constructions. Locations with fine sedimentary soil have less bearing capacity and may require soil reinforcement measures for the foundation work of planned buildings. The till in the area is considered to have good bearing capacity, but for excavations and/or deep foundation work, stability problems may occur because of the combination of fine grained till at depth and high groundwater level. The present work provides a general description of the ground conditions at the site. However, further investigations will be required to support more detailed

  8. Biomass and mineral element responses of a Serengeti short-grass species to nitrogen supply and defoliation: compensation requires a critical [N].

    Science.gov (United States)

    Hamilton Iii, E William; Giovannini, Michele S; Moses, Stephanie A; Coleman, James S; McNaughton, Samuel J

    1998-09-01

    Large mammalian herbivores in grassland ecosystems influence plant growth dynamics in many ways, including the removal of plant biomass and the return of nutrients to the soil. A 10-week growth chamber experiment examined the responses of Sporobolus kentrophyllus from the heavily grazed short-grass plains of Serengeti National Park, Tanzania, to simulated grazing and varying nitrogen nutrition. Plants were subjected to two clipping treatments (clipped and unclipped) and five nitrogen levels (weekly applications at levels equivalent to 0, 1, 5, 10, and 40 g N m(-2)), the highest being equivalent to a urine hit. Tiller and stolon production were measured weekly. Total biomass at harvest was partitioned by plant organ and analyzed for nitrogen and mineral element composition. Tiller and stolon production reached a peak at 3-5 weeks in unclipped plants, then declined drastically, but tiller number increased continually in clipped plants; this differential effect was enhanced at higher N levels. Total plant production increased substantially with N supply, was dominated by aboveground production, and was similar in clipped and unclipped plants, except at high nitrogen levels where clipped plants produced more. Much of the standing biomass of unclipped plants was standing dead and stem; most of the standing biomass of clipped plants was live leaf with clipped plants having significantly more leaf than unclipped plants. However, leaf nitrogen was stimulated by clipping only in plants receiving levels of N application above 1 g N m(-2) which corresponded to a tissue concentration of 2.5% N. Leaf N concentration was lower in unclipped plants and increased with level of N. Aboveground N and mineral concentrations were consistently greater than belowground levels and while clipping commonly promoted aboveground concentrations, it generally diminished those belowground. In general, clipped plants exhibited increased leaf elemental concentrations of K, P, and Mg

  9. A simple in vitro RNA editing assay for chloroplast transcripts using fluorescent dideoxynucleotides: distinct types of sequence elements required for editing of ndh transcripts.

    Science.gov (United States)

    Sasaki, Tadamasa; Yukawa, Yasushi; Wakasugi, Tatsuya; Yamada, Kyoji; Sugiura, Masahiro

    2006-09-01

    RNA editing is found in various transcripts from land plant chloroplasts. In tobacco chloroplasts, C-to-U conversion occurs at 36 specific sites including two sites identified in this work. Our RNA editing assay system using chloroplast extracts facilitated biochemical analyses of editing reactions but required mRNAs labeled with (32)P at specific sites. Here, we have improved the in vitro system using fluorescence-labeled chain terminators, ddGTP and ddATP, and have measured the editing activity at 19 sites in ndh transcripts. Editing activities varied from site to site. It has been reported that one editing site in ndhA mRNAs is present in spinach but absent in tobacco, but a corresponding editing capacity had been found in vivo in tobacco using biolistic transformation. We confirmed biochemically the existence of this activity in tobacco extracts. Using the non-radioactive assay, we examined sequences essential for editing within a 50-nt mRNA region encompassing an editing site. Editing of the ndhB-2 site requires a short sequence in front of the editing site, while that of the ndhF mRNA requires two separate regions, a sequence surrounding the editing site and a 5' distal sequence. These results suggest that distinct editing mechanisms are present in chloroplasts.

  10. A sterol-regulatory element binding protein is required for cell polarity, hypoxia adaptation, azole drug resistance, and virulence in Aspergillus fumigatus.

    Directory of Open Access Journals (Sweden)

    Sven D Willger

    2008-11-01

    Full Text Available At the site of microbial infections, the significant influx of immune effector cells and the necrosis of tissue by the invading pathogen generate hypoxic microenvironments in which both the pathogen and host cells must survive. Currently, whether hypoxia adaptation is an important virulence attribute of opportunistic pathogenic molds is unknown. Here we report the characterization of a sterol-regulatory element binding protein, SrbA, in the opportunistic pathogenic mold, Aspergillus fumigatus. Loss of SrbA results in a mutant strain of the fungus that is incapable of growth in a hypoxic environment and consequently incapable of causing disease in two distinct murine models of invasive pulmonary aspergillosis (IPA. Transcriptional profiling revealed 87 genes that are affected by loss of SrbA function. Annotation of these genes implicated SrbA in maintaining sterol biosynthesis and hyphal morphology. Further examination of the SrbA null mutant consequently revealed that SrbA plays a critical role in ergosterol biosynthesis, resistance to the azole class of antifungal drugs, and in maintenance of cell polarity in A. fumigatus. Significantly, the SrbA null mutant was highly susceptible to fluconazole and voriconazole. Thus, these findings present a new function of SREBP proteins in filamentous fungi, and demonstrate for the first time that hypoxia adaptation is likely an important virulence attribute of pathogenic molds.

  11. Thorium utilization program. Quarterly progress report for the period ending February 28, 1977. [Fuel element crushing, burning; particle classification; solvent extraction; dry solids handling; plant management; HET fuel shipping; HTGR recycle demonstration facility

    Energy Technology Data Exchange (ETDEWEB)

    1977-03-01

    General Atomic Thorium Utilization Program activities progressed on schedule during the quarter, with continuation of the head-end reprocessing equipment testing program. Individual testing of the tertiary, oversize crushers and the screener was completed. Preparation of the equipment for testing as a system is under way. Tests on the tertiary crusher revealed no operating problems. No material holdup areas or bypass of the crushing cavity were detected. The initial issue of a functional level diagram for the Fuel Element Size Reduction System has been prepared for preliminary review. Heat transfer coefficients were calculated from data obtained in six 0.40-m primary burner heatup runs. Six runs were made on the 0.20-m primary burner. Other significant 0.20-m burner work included fabrication and initial testing of an electrical resistance probe bed level sensor and preliminary heat transfer design calculations for determining the cooling requirements to maintain the recycling fines cyclone exit temperature at approximately 500/sup 0/C. The conceptual design of the engineering-scale dissolver-centrifuge for incorporation into the head-end line was completed. Three solvent extraction feed adjustment runs were completed. Two of the runs were representative of the continuous intercycle concentration step. The other run was a continuous operation which utilized leacher product as feed. Progress with dry solids handling component and system testing continues. Efforts were focused on completion of the HET fuel shipping conceptual design report, development of detailed costs, and identification of all system interfaces. The Reprocessing Flowsheet Review and Materials Balance Study of reprocessing head-end and off-gas treatment systems is in technical review.

  12. Spanish-language community-based mental health treatment programs, policy-required language-assistance programming, and mental health treatment access among Spanish-speaking clients

    National Research Council Canada - National Science Library

    Snowden, Lonnie R; McClellan, Sean R

    2013-01-01

    We investigated the extent to which implementing language assistance programming through contracting with community-based organizations improved the accessibility of mental health care under Medi-Cal...

  13. Laser Setup for Volume Diffractive Optical Elements Recording in Photo-Thermo-Refractive Glass

    Science.gov (United States)

    2016-04-14

    published in non peer-reviewed journals : Final Report: Laser Setup for Volume Diffractive Optical Elements Recording in Photo-Thermo-Refractive Glass...enhancement of lasers brightness and fine spectral filtering. However, further increase of size of holographic optical elements , which are required for high...PROGRAM ELEMENT NUMBER 5b. GRANT NUMBER 5a. CONTRACT NUMBER Form Approved OMB NO. 0704-0188 3. DATES COVERED (From - To) - Approved for Public Release

  14. Expression of MUC17 is regulated by HIF1α-mediated hypoxic responses and requires a methylation-free hypoxia responsible element in pancreatic cancer.

    Directory of Open Access Journals (Sweden)

    Sho Kitamoto

    Full Text Available MUC17 is a type 1 membrane-bound glycoprotein that is mainly expressed in the digestive tract. Recent studies have demonstrated that the aberrant overexpression of MUC17 is correlated with the malignant potential of pancreatic ductal adenocarcinomas (PDACs; however, the exact regulatory mechanism of MUC17 expression has yet to be identified. Here, we provide the first report of the MUC17 regulatory mechanism under hypoxia, an essential feature of the tumor microenvironment and a driving force of cancer progression. Our data revealed that MUC17 was significantly induced by hypoxic stimulation through a hypoxia-inducible factor 1α (HIF1α-dependent pathway in some pancreatic cancer cells (e.g., AsPC1, whereas other pancreatic cancer cells (e.g., BxPC3 exhibited little response to hypoxia. Interestingly, these low-responsive cells have highly methylated CpG motifs within the hypoxia responsive element (HRE, 5'-RCGTG-3', a binding site for HIF1α. Thus, we investigated the demethylation effects of CpG at HRE on the hypoxic induction of MUC17. Treatment of low-responsive cells with 5-aza-2'-deoxycytidine followed by additional hypoxic incubation resulted in the restoration of hypoxic MUC17 induction. Furthermore, DNA methylation of HRE in pancreatic tissues from patients with PDACs showed higher hypomethylation status as compared to those from non-cancerous tissues, and hypomethylation was also correlated with MUC17 mRNA expression. Taken together, these findings suggested that the HIF1α-mediated hypoxic signal pathway contributes to MUC17 expression, and DNA methylation of HRE could be a determinant of the hypoxic inducibility of MUC17 in pancreatic cancer cells.

  15. Chemistry of superheavy elements

    Energy Technology Data Exchange (ETDEWEB)

    Schaedel, M. [Japan Atomic Energy Agency, Tokai, Ibaraki (Japan). Advanced Science Research Center; GSI Helmholtz Center for Heavy Ion Research, Darmstadt (Germany)

    2012-07-01

    The chemistry of superheavy elements - or transactinides from their position in the Periodic Table - is summarized. After giving an overview over historical developments, nuclear aspects about synthesis of neutron-rich isotopes of these elements, produced in hot-fusion reactions, and their nuclear decay properties are briefly mentioned. Specific requirements to cope with the one-atom-at-a-time situation in automated chemical separations and recent developments in aqueous-phase and gas-phase chemistry are presented. Exciting, current developments, first applications, and future prospects of chemical separations behind physical recoil separators ('pre-separator') are discussed in detail. The status of our current knowledge about the chemistry of rutherfordium (Rf, element 104), dubnium (Db, element 105), seaborgium (Sg, element 106), bohrium (Bh, element 107), hassium (Hs, element 108), copernicium (Cn, element 112), and element 114 is discussed from an experimental point of view. Recent results are emphasized and compared with empirical extrapolations and with fully-relativistic theoretical calculations, especially also under the aspect of the architecture of the Periodic Table. (orig.)

  16. Medicare Program; Revisions to Payment Policies Under the Physician Fee Schedule and Other Revisions to Part B for CY 2017; Medicare Advantage Bid Pricing Data Release; Medicare Advantage and Part D Medical Loss Ratio Data Release; Medicare Advantage Provider Network Requirements; Expansion of Medicare Diabetes Prevention Program Model; Medicare Shared Savings Program Requirements. Final rule.

    Science.gov (United States)

    2016-11-15

    This major final rule addresses changes to the physician fee schedule and other Medicare Part B payment policies, such as changes to the Value Modifier, to ensure that our payment systems are updated to reflect changes in medical practice and the relative value of services, as well as changes in the statute. This final rule also includes changes related to the Medicare Shared Savings Program, requirements for Medicare Advantage Provider Networks, and provides for the release of certain pricing data from Medicare Advantage bids and of data from medical loss ratio reports submitted by Medicare health and drug plans. In addition, this final rule expands the Medicare Diabetes Prevention Program model.

  17. A hypoxia response element in the Vegfa promoter is required for basal Vegfa expression in skin and for optimal granulation tissue formation during wound healing in mice.

    Directory of Open Access Journals (Sweden)

    Domenic Ciarlillo

    Full Text Available Hypoxia in skin wounds is thought to contribute to healing through the induction of hypoxia inducible factor-1 (HIF-1. Although HIF-1 can regulate the expression of vascular endothelial growth factor A (Vegfa, whether hypoxia and HIF-1 are required to induce Vegfa expression in the context of wound healing is unknown. To test this hypothesis, we evaluated Vegfa expression and wound healing in mutant mice that lack a functional HIF-1 binding site in the Vegfa promoter. Full-thickness excisional wounds were made using a biopsy punch, left to heal by second intention, and granulation tissue isolated on a time course during healing. mRNA levels of Vegfa and its target genes platelet-derived growth factors B (Pdgfb and stromal cell-derived factor-1 (Sdf1 were measured by RT-qPCR, and HIF-1alpha and VEGFA protein levels measured by immunoblotting. Lower levels of Vegfa, Pdgf1 and Sdf1 mRNA were found in intact skin of mutant mice relative to wild-type controls (n = 6 mice/genotype, whereas levels in granulation tissue during wound healing were unaltered. VEGFA protein levels were also lower in intact skin of the mutant versus the wild-type mice. Decreased Vegfa mRNA levels in skin of mutant mice could not be attributed to decreased HIF-1alpha protein expression, and were therefore a consequence of the loss of HIF-1 responsiveness of the Vegfa promoter. Comparative histologic analyses of healing wounds in mutant and wild-type mice (n = 8 mice/genotype revealed significant defects in granulation tissue in the mutant mice, both in terms of quantity and capillary density, although epithelialization and healing rates were unaltered. We conclude that HIF-1 is not a major regulator of Vegfa expression during wound healing; rather, it serves to maintain basal levels of expression of Vegfa and its target genes in intact skin, which are required for optimal granulation tissue formation in response to wounding.

  18. 24 CFR 906.15 - Requirements applicable to a family purchasing a property under a homeownership program.

    Science.gov (United States)

    2010-04-01

    ... activities; (2) Criminal activity; (3) Participation in homeownership counseling programs; and (4) Evidence... program must be a low-income family, as defined in section 3 of the 1937 Act (42 U.S.C. 1437a), at the... association fees) will not exceed the sum of: (i) 35 percent of the applicant's adjusted income as defined in...

  19. Wartime Requirements for Ammunition, Materiel, and Personnel (WARRAMP). Volume IV. Ammunition Post-Processor Program Maintenance Manual.

    Science.gov (United States)

    1982-02-01

    09 00 9 0:0 : a 0 w cocoa 0 00000 00000 00000 00 000 0oco0 00000 0000 0m0000 a ....... ....... .............. Figure 111.1.6 43 : 0 00 0 00 C 0 0 00 0...associated with the program are: 1) Input data errors, either in content or format; 2) Program errors or bugs and 3) operating system errors

  20. NRC review of Electric Power Research Institute's Advanced Light Reactor Utility Requirements Document - Program summary, Project No. 669

    Energy Technology Data Exchange (ETDEWEB)

    1992-08-01

    The staff of the US Nuclear Regulatory Commission has prepared Volume 1 of a safety evaluation report (SER), NRC Review of Electric Power Research Institute's Advanced Light Water Reactor Utility Requirements Document -- Program Summary,'' to document the results of its review of the Electric Power Research Institute's Advanced Light Water Reactor Utility Requirements Document.'' This SER provides a discussion of the overall purpose and scope of the Requirements Document, the background of the staff's review, the review approach used by the staff, and a summary of the policy and technical issues raised by the staff during its review.

  1. Safety and business benefit analysis of NASA's aviation safety program

    Science.gov (United States)

    2004-09-20

    NASA Aviation Safety Program elements encompass a wide range of products that require both public and private investment. Therefore, two methods of analysis, one relating to the public and the other to the private industry, must be combined to unders...

  2. Neutronic fuel element fabrication

    Science.gov (United States)

    Korton, George

    2004-02-24

    This disclosure describes a method for metallurgically bonding a complete leak-tight enclosure to a matrix-type fuel element penetrated longitudinally by a multiplicity of coolant channels. Coolant tubes containing solid filler pins are disposed in the coolant channels. A leak-tight metal enclosure is then formed about the entire assembly of fuel matrix, coolant tubes and pins. The completely enclosed and sealed assembly is exposed to a high temperature and pressure gas environment to effect a metallurgical bond between all contacting surfaces therein. The ends of the assembly are then machined away to expose the pin ends which are chemically leached from the coolant tubes to leave the coolant tubes with internal coolant passageways. The invention described herein was made in the course of, or under, a contract with the U.S. Atomic Energy Commission. It relates generally to fuel elements for neutronic reactors and more particularly to a method for providing a leak-tight metal enclosure for a high-performance matrix-type fuel element penetrated longitudinally by a multiplicity of coolant tubes. The planned utilization of nuclear energy in high-performance, compact-propulsion and mobile power-generation systems has necessitated the development of fuel elements capable of operating at high power densities. High power densities in turn require fuel elements having high thermal conductivities and good fuel retention capabilities at high temperatures. A metal clad fuel element containing a ceramic phase of fuel intimately mixed with and bonded to a continuous refractory metal matrix has been found to satisfy the above requirements. Metal coolant tubes penetrate the matrix to afford internal cooling to the fuel element while providing positive fuel retention and containment of fission products generated within the fuel matrix. Metal header plates are bonded to the coolant tubes at each end of the fuel element and a metal cladding or can completes the fuel-matrix enclosure

  3. NASA Constellation Program (CxP) Key Driving Requirements and Element Descriptions for International Architecture Working Group (IAWG) Functional Teams Human Transportation Cargo Transportation

    Science.gov (United States)

    Martinez, Roland M.

    2009-01-01

    The NASA Constellation uncrewed cargo mission delivers cargo to any designated location on the lunar surface (or other staging point) in a single mission. This capability is used to deliver surface infrastructure needed for lunar outpost construction, to provide periodic logistics resupply to support a continuous human lunar presence, and potentially deliver other assets to various locations.In the nominal mission mode, the Altair lunar lander is launched on Ares V into Low Earth Orbit (LEO), following a short Low Earth Orbit (LEO) loiter period, the Earth Departure Stage (EDS) performs the Trans Lunar Injection (TLI) burn and is then jettisoned. The Altair performs translunar trajectory correction maneuvers as necessary and performs the Lunar Orbit Insertion (LOI) burn. Altair then descends to the surface to land near a designated target, presumably in proximity to an Outpost location or another site of interest for exploration.Alternatively, the EDS and Altair Descent Stage could deliver assets to various staging points within their propulsive capabilities.

  4. Medicare and Medicaid programs: hospital outpatient prospective payment; ambulatory surgical center payment; hospital value-based purchasing program; physician self-referral; and patient notification requirements in provider agreements. Final rule with comment period.

    Science.gov (United States)

    2011-11-30

    This final rule with comment period revises the Medicare hospital outpatient prospective payment system (OPPS) for CY 2012 to implement applicable statutory requirements and changes arising from our continuing experience with this system. In this final rule with comment period, we describe the changes to the amounts and factors used to determine the payment rates for Medicare hospital outpatient services paid under the OPPS. In addition, this final rule with comment period updates the revised Medicare ambulatory surgical center (ASC) payment system to implement applicable statutory requirements and changes arising from our continuing experience with this system. In this final rule with comment period, we set forth the relative payment weights and payment amounts for services furnished in ASCs, specific HCPCS codes to which these changes apply, and other ratesetting information for the CY 2012 ASC payment system. We are revising the requirements for the Hospital Outpatient Quality Reporting (OQR) Program, adding new requirements for ASC Quality Reporting System, and making additional changes to provisions of the Hospital Inpatient Value-Based Purchasing (VBP) Program. We also are allowing eligible hospitals and CAHs participating in the Medicare Electronic Health Record (EHR) Incentive Program to meet the clinical quality measure reporting requirement of the EHR Incentive Program for payment year 2012 by participating in the 2012 Medicare EHR Incentive Program Electronic Reporting Pilot. Finally, we are making changes to the rules governing the whole hospital and rural provider exceptions to the physician self-referral prohibition for expansion of facility capacity and changes to provider agreement regulations on patient notification requirements.

  5. 36 CFR 230.35 - FLEP elements.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 2 2010-07-01 2010-07-01 false FLEP elements. 230.35 Section... FORESTRY ASSISTANCE Forest Land Enhancement Program § 230.35 FLEP elements. (a) States may use FLEP funds... through the following elements: (1) Development and implementation of educational programs; (2) Resource...

  6. Analysis of requirements and the necessary investments in the railway station adjustment program for persons with special needs

    Directory of Open Access Journals (Sweden)

    Atanasković Predrag

    2012-03-01

    Full Text Available People with special needs from the standpoint of social communities have specific requirements for access, mobility, entry and exit of railway vehicles designated to transport passengers. The EU has defined standards and requirements related to persons with special needs. The aim of this paper is to analyze the technical requirements of equipment and identify the necessary investment funds related to the increasing mobility of persons with special needs in the rail transportation system. This analysis would be one of the initial steps approaching the conditions and requirements that apply in the EU in adapting the system of transport for people with special needs.

  7. Environmental Restoration Information Resource Management Program Plan

    Energy Technology Data Exchange (ETDEWEB)

    1994-09-01

    The Environmental Restoration Information Resources Management (ER IRM) Program Plan defines program requirements, organizational structures and responsibilities, and work breakdown structure and to establish an approved baseline against which overall progress of the program as well as the effectiveness of its management will be measured. This plan will guide ER IRM Program execution and define the program`s essential elements. This plan will be routinely updated to incorporate key decisions and programmatic changes and will serve as the project baseline document. Environmental Restoration Waste Management Program intersite procedures and work instructions will be developed to facilitate the implementation of this plan.

  8. Screening computer-assisted dosage programs for anticoagulation with warfarin and other vitamin K antagonists: minimum safety requirements for individual programs

    DEFF Research Database (Denmark)

    Poller, L; Roberts, C; Ibrahim, S

    2009-01-01

    Based on the results of the previous European Action on Anticoagulation (EAA) multicenter study, a simplified minimum procedure is described for screening the safety and effectiveness of marketed programs for dosage of oral anticoagulant drugs (vitamin K antagonists). The aim was to demonstrate non...

  9. JAC3D -- A three-dimensional finite element computer program for the nonlinear quasi-static response of solids with the conjugate gradient method; Yucca Mountain Site Characterization Project

    Energy Technology Data Exchange (ETDEWEB)

    Biffle, J.H.

    1993-02-01

    JAC3D is a three-dimensional finite element program designed to solve quasi-static nonlinear mechanics problems. A set of continuum equations describes the nonlinear mechanics involving large rotation and strain. A nonlinear conjugate gradient method is used to solve the equation. The method is implemented in a three-dimensional setting with various methods for accelerating convergence. Sliding interface logic is also implemented. An eight-node Lagrangian uniform strain element is used with hourglass stiffness to control the zero-energy modes. This report documents the elastic and isothermal elastic-plastic material model. Other material models, documented elsewhere, are also available. The program is vectorized for efficient performance on Cray computers. Sample problems described are the bending of a thin beam, the rotation of a unit cube, and the pressurization and thermal loading of a hollow sphere.

  10. JAC2D: A two-dimensional finite element computer program for the nonlinear quasi-static response of solids with the conjugate gradient method; Yucca Mountain Site Characterization Project

    Energy Technology Data Exchange (ETDEWEB)

    Biffle, J.H.; Blanford, M.L.

    1994-05-01

    JAC2D is a two-dimensional finite element program designed to solve quasi-static nonlinear mechanics problems. A set of continuum equations describes the nonlinear mechanics involving large rotation and strain. A nonlinear conjugate gradient method is used to solve the equations. The method is implemented in a two-dimensional setting with various methods for accelerating convergence. Sliding interface logic is also implemented. A four-node Lagrangian uniform strain element is used with hourglass stiffness to control the zero-energy modes. This report documents the elastic and isothermal elastic/plastic material model. Other material models, documented elsewhere, are also available. The program is vectorized for efficient performance on Cray computers. Sample problems described are the bending of a thin beam, the rotation of a unit cube, and the pressurization and thermal loading of a hollow sphere.

  11. Element 115

    OpenAIRE

    Forsberg, Ulrika

    2016-01-01

    This thesis is devoted to detailed studies of element 115 decay chains using the highly efficient multi-coincidence alpha, electron, gamma and X-ray detector setup TASISpec at the gas-filled separator TASCA at GSI, Darmstadt, Germany. In a three-week long experiment thirty new decay chains assumed to stem from element 115 isotopes were observed together with the very first detections of gamma rays and potential X-rays from these nuclei. Paper I describes preparations in terms of optimisations...

  12. Divergent picornavirus IRES elements

    DEFF Research Database (Denmark)

    Belsham, Graham

    2009-01-01

    Internal ribosome entry site (IRES) elements were first identified about 20 years ago within the 5' untranslated region of picornavirus RNAs. They direct a cap-independent mechanism of translation initiation on the viral RNA. Within the picornavirus family it is now known that there are four...... classes of IRES element which vary in size (450-270nt), they also have different, complex, secondary structures and distinct requirements for cellular proteins to allow them to function. This review describes the features of each class of picornavirus IRES element but focuses on the characteristics...... of the most recently described group, initially identified within the porcine teschovirus-1 RNA, which has strong similarities to the IRES elements from within the genomes of hepatitis C virus and the pestiviruses which are members of the flavivirus family. The selection of the initiation codon...

  13. 34 CFR 602.10 - Link to Federal programs.

    Science.gov (United States)

    2010-07-01

    ...— (a) If the agency accredits institutions of higher education, its accreditation is a required element... programs; or (b) If the agency accredits institutions of higher education or higher education programs, or... 34 Education 3 2010-07-01 2010-07-01 false Link to Federal programs. 602.10 Section 602.10...

  14. Handoffs in the era of duty hours reform: a focused review and strategy to address changes in the Accreditation Council for Graduate Medical Education Common Program Requirements.

    Science.gov (United States)

    DeRienzo, Christopher M; Frush, Karen; Barfield, Michael E; Gopwani, Priya R; Griffith, Brian C; Jiang, Xiaoyin; Mehta, Ankit I; Papavassiliou, Paulie; Rialon, Kristy L; Stephany, Alyssa M; Zhang, Tian; Andolsek, Kathryn M

    2012-04-01

    With changes in the Accreditation Council for Graduate Medical Education (ACGME) Common Program Requirements related to transitions in care effective July 1, 2011, sponsoring institutions and training programs must develop a common structure for transitions in care as well as comprehensive curricula to teach and evaluate patient handoffs. In response to these changes, within the Duke University Health System, the resident-led Graduate Medical Education Patient Safety and Quality Council performed a focused review of the handoffs literature and developed a plan for comprehensive handoff education and evaluation for residents and fellows at Duke. The authors present the results of their focused review, concentrating on the three areas of new ACGME expectations--structure, education, and evaluation--and describe how their findings informed the broader initiative to comprehensively address transitions in care managed by residents and fellows. The process of developing both institution-level and program-level initiatives is reviewed, including the development of an interdisciplinary minimal data set for handoff core content, training and education programs, and an evaluation strategy. The authors believe the final plan fully addresses both Duke's internal goals and the revised ACGME Common Program Requirements and may serve as a model for other institutions to comprehensively address transitions in care and to incorporate resident and fellow leadership into a broad, health-system-level quality improvement initiative.

  15. 75 FR 77229 - Federal Requirements Under the Underground Injection Control (UIC) Program for Carbon Dioxide (CO2

    Science.gov (United States)

    2010-12-10

    ...: Category Examples of regulated entities Private Owners or Operators of CO2 injection wells used for Class VI GS. Private Owners or Operators of existing CO2 injection wells transitioning from Class I, II, or... Class VI Requirements Reporting requirement Subpart RR UIC Class VI Quantity of CO2 transferred Yes N/A...

  16. Structural and Regulatory Elements of HCV NS5B Polymerase – β-Loop and C-Terminal Tail – Are Required for Activity of Allosteric Thumb Site II Inhibitors

    Science.gov (United States)

    Boyce, Sarah E.; Tirunagari, Neeraj; Niedziela-Majka, Anita; Perry, Jason; Wong, Melanie; Kan, Elaine; Lagpacan, Leanna; Barauskas, Ona; Hung, Magdeleine; Fenaux, Martijn; Appleby, Todd; Watkins, William J.; Schmitz, Uli; Sakowicz, Roman

    2014-01-01

    Elucidation of the mechanism of action of the HCV NS5B polymerase thumb site II inhibitors has presented a challenge. Current opinion holds that these allosteric inhibitors stabilize the closed, inactive enzyme conformation, but how this inhibition is accomplished mechanistically is not well understood. Here, using a panel of NS5B proteins with mutations in key regulatory motifs of NS5B – the C-terminal tail and β-loop – in conjunction with a diverse set of NS5B allosteric inhibitors, we show that thumb site II inhibitors possess a distinct mechanism of action. A combination of enzyme activity studies and direct binding assays reveals that these inhibitors require both regulatory elements to maintain the polymerase inhibitory activity. Removal of either element has little impact on the binding affinity of thumb site II inhibitors, but significantly reduces their potency. NS5B in complex with a thumb site II inhibitor displays a characteristic melting profile that suggests stabilization not only of the thumb domain but also the whole polymerase. Successive truncations of the C-terminal tail and/or removal of the β-loop lead to progressive destabilization of the protein. Furthermore, the thermal unfolding transitions characteristic for thumb site II inhibitor – NS5B complex are absent in the inhibitor – bound constructs in which interactions between C-terminal tail and β-loop are abolished, pointing to the pivotal role of both regulatory elements in communication between domains. Taken together, a comprehensive picture of inhibition by compounds binding to thumb site II emerges: inhibitor binding provides stabilization of the entire polymerase in an inactive, closed conformation, propagated via coupled interactions between the C-terminal tail and β-loop. PMID:24416288

  17. Governing Critical ICT: Elements that Require Attention

    NARCIS (Netherlands)

    Luiijf, H.A.M.; Klaver, M.H.A.

    2015-01-01

    With respect to critical information and communication technologies (ICT), nations most often declare their national critical infrastructure to include telecommunication services and in some cases critical services offered by key Internet Service Providers (ISP). This paper debates whether nations,

  18. 45 CFR 1351.20 - What are the additional requirements under a Runaway and Homeless Youth Program grant?

    Science.gov (United States)

    2010-10-01

    ...: • Shelter facility staff development, • Aftercare services or counseling, • Fund raising techniques, • Youth and Family counseling, and • Crisis intervention techniques. (b) Grantees will be required to...

  19. AMPS data management requirements study. [user manuals (computer programs)/display devices - computerized simulation/experimentation/ionosphere

    Science.gov (United States)

    1975-01-01

    A data simulation is presented for instruments and associated control and display functions required to perform controlled active experiments of the atmosphere. A comprehensive user's guide is given for the data requirements and software developed for the following experiments: (1) electromagnetic wave transmission; (2) passive observation of ambient plasmas; (3) ionospheric measurements with a subsatellite; (4) electron accelerator beam measurements; and (5) measurement of acoustic gravity waves in the sodium layer using lasers. A complete description of each experiment is given.

  20. 34 CFR 371.21 - What are the special application requirements related to the State plan program?

    Science.gov (United States)

    2010-07-01

    ... the representative of the service providing organization and each American Indian with disabilities being served. (Authority: Secs. 12(c) and 101(a)(9) of the Act; 29 U.S.C. 711(c) and 721(a)(9)) (f) American Indians with disabilities living on Federal or State reservations where service programs are being...

  1. Mobilization and Defense Management Technical Report Series. Effective Integration of Faculty Requirements into Army System Acquisition Programs.

    Science.gov (United States)

    1983-05-01

    in maintenance facilities had to be modified on short notice.3 The M-i tank cannot fit in existing tank wash racks with its side skirts in the raised...qtrs IWRM Office DOS/RU=. Fxj JC 90t Mgmt Div and 1ST Asta, IP Div. 331OWs INJO am, rnization program severely con strained to facilities issus

  2. Safety in Riding Programs: A Director's Guide.

    Science.gov (United States)

    Kpachavi, Teresa

    1996-01-01

    Camp riding programs should be examined regularly for liability and risk management issues. Elements of a basic safety assessment include requiring proper safety apparel, removing obstructions from riding rings, ensuring doors and gates are closed, requiring use of lead ropes, securing equine medications, banning smoking, posting written…

  3. National School Lunch Program and School Breakfast Program: nutrition standards for all foods sold in school as required by the Healthy, Hunger-Free Kids Act of 2010. Interim final rule.

    Science.gov (United States)

    2013-06-28

    This interim final rule amends the National School Lunch Program and School Breakfast Program regulations to establish nutrition standards for all foods sold in schools, other than food sold under the lunch and breakfast programs. Amendments made by Section 208 of the Healthy, Hunger-Free Kids Act of 2010 (HHFKA) require the Secretary to establish nutrition standards for such foods, consistent with the most recent Dietary Guidelines for Americans, and directs the Secretary to consider authoritative scientific recommendations for nutrition standards; existing school nutrition standards, including voluntary standards for beverages and snack foods; current State and local standards; the practical application of the nutrition standards; and special exemptions for infrequent school-sponsored fundraisers (other than fundraising through vending machines, school stores, snack bars, à la carte sales and any other exclusions determined by the Secretary). In addition, this interim final rule requires schools participating in the National School Lunch Program and School Breakfast Program to make potable water available to children at no charge in the place where lunches are served during the meal service, consistent with amendments made by section 203 of the HHFKA, and in the cafeteria during breakfast meal service. This interim final rule is expected to improve the health and well-being of the Nation's children, increase consumption of healthful foods during the school day, and create an environment that reinforces the development of healthy eating habits.

  4. The Communication of the User’s Requirements to the System Program Office during the Ongoing System Development Process.

    Science.gov (United States)

    1987-09-01

    Summary of Operational Exp) DISAT (Frequency User expresses Dissatisfaction) FREQUENCYI I I I Some- I Almost I I I Neverl Rarely I times I Always I Always...provided by survey questions l (variable UDISSAT) and 22 (variable DISAT ) are biased because the respondents are program office personnel. This is...Communication USERLOC(ConUS or OConUS) DISAT (Frequency User expresses Dissatisfaction) FREQUENCY I I I I Some- I Almost I INeverlRarely I times I Always I

  5. Software requirements

    CERN Document Server

    Wiegers, Karl E

    2003-01-01

    Without formal, verifiable software requirements-and an effective system for managing them-the programs that developers think they've agreed to build often will not be the same products their customers are expecting. In SOFTWARE REQUIREMENTS, Second Edition, requirements engineering authority Karl Wiegers amplifies the best practices presented in his original award-winning text?now a mainstay for anyone participating in the software development process. In this book, you'll discover effective techniques for managing the requirements engineering process all the way through the development cy

  6. Titan : A new facility for ultraclean sampling of trace elements and isotopes in the deep oceans in the international Geotraces program

    NARCIS (Netherlands)

    de Baar, H.J.W.; Timmermans, K.R; Laan, P.; De Porto, H.H.; Ober, S.; Blom, J.J.; Bakker, M.C.; Schilling, J; Sarthou, G.; Smit, M. G.; Klunder, M

    2008-01-01

    Towards more rapid ultraclean sampling of deep ocean waters for trace elements, a novel rectangular frame was constructed of titanium, holding two rows of 12 samplers, as well as various sensors. The frame is deployed to deep ocean waters by an 8000 m length Kevlar wire with internal power and

  7. The Tarsoft software: A computer program to learn the elemental theory for the urban wastewater treatment; Tarsoft: programa de ordenador para el aprendizaje de la teoria basica sobre la depuracion de las aguas residuales urbanas

    Energy Technology Data Exchange (ETDEWEB)

    Parra Narvaez, R.; Baldasano Recio, J.M. [Universitat Politecnica de Catalunya. Barcelona (Spain)

    1998-12-31

    It` ve been developed a first version of the computer program Tarsoft, with the objective to be a Informatic contribution for the education and training of the knowledge about the urban wastewater treatment. This article describe in general form, the main characteristic of this computer program, the minimal hardware and software requirements, the theoretical topics than it include, the presentation form of the variety alfanumerical and graphical interactive information and design modules of the different treatment process. (Author) 20 refs.

  8. 49 CFR 563.7 - Data elements.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 6 2010-10-01 2010-10-01 false Data elements. 563.7 Section 563.7 Transportation..., DEPARTMENT OF TRANSPORTATION EVENT DATA RECORDERS § 563.7 Data elements. (a) Data elements required for all vehicles. Each vehicle equipped with an EDR must record all of the data elements listed in Table I, during...

  9. A prospective evaluation of the safety and efficacy of the TAXUS Element paclitaxel-eluting coronary stent system for the treatment of de novo coronary artery lesions: Design and statistical methods of the PERSEUS clinical program

    Directory of Open Access Journals (Sweden)

    Wehrenberg Scott

    2010-01-01

    Full Text Available Abstract Background Paclitaxel-eluting stents decrease angiographic and clinical restenosis following percutaneous coronary intervention compared to bare metal stents. TAXUS Element is a third-generation paclitaxel-eluting stent which incorporates a novel, thinner-strut, platinum-enriched metal alloy platform. The stent is intended to have enhanced radiopacity and improved deliverability compared to other paclitaxel-eluting stents. The safety and efficacy of the TAXUS Element stent are being evaluated in the pivotal PERSEUS clinical trials. Methods/Design The PERSEUS trials include two parallel studies of the TAXUS Element stent in single, de novo coronary atherosclerotic lesions. The PERSEUS Workhorse study is a prospective, randomized (3:1, single-blind, non-inferiority trial in subjects with lesion length ≤28 mm and vessel diameter ≥2.75 mm to ≤4.0 mm which compares TAXUS Element to the TAXUS Express2 paclitaxel-eluting stent system. The Workhorse study employs a novel Bayesian statistical approach that uses prior information to limit the number of study subjects exposed to the investigational device and thus provide a safer and more efficient analysis of the TAXUS Element stent. PERSEUS Small Vessel is a prospective, single-arm, superiority trial in subjects with lesion length ≤20 mm and vessel diameter ≥2.25 mm to Discussion The TAXUS PERSEUS clinical trial program uses a novel statistical approach to evaluate whether design and metal alloy iterations in the TAXUS Element stent platform provide comparable safety and improved procedural performance compared to the previous generation Express stent. PERSEUS trial enrollment is complete and primary endpoint data are expected in 2010. PERSEUS Workhorse and Small Vessel are registered at http://www.clinicaltrials.gov, identification numbers NCT00484315 and NCT00489541.

  10. 77 FR 24628 - World Trade Center Health Program Requirements for the Addition of New WTC-Related Health Conditions

    Science.gov (United States)

    2012-04-25

    ... consideration. HHS notes that scientists generally look for consistency in terms of disease-mechanism theories... costs to HHS of considering possible additions. Under any circumstance, HHS would be required to conduct...; it does not create a serious inconsistency or otherwise interfere with an action taken or planned by...

  11. Finite element methods for engineers

    CERN Document Server

    Fenner, Roger T

    2013-01-01

    This book is intended as a textbook providing a deliberately simple introduction to finite element methods in a way that should be readily understandable to engineers, both students and practising professionals. Only the very simplest elements are considered, mainly two dimensional three-noded “constant strain triangles”, with simple linear variation of the relevant variables. Chapters of the book deal with structural problems (beams), classification of a broad range of engineering into harmonic and biharmonic types, finite element analysis of harmonic problems, and finite element analysis of biharmonic problems (plane stress and plane strain). Full Fortran programs are listed and explained in detail, and a range of practical problems solved in the text. Despite being somewhat unfashionable for general programming purposes, the Fortran language remains very widely used in engineering. The programs listed, which were originally developed for use on mainframe computers, have been thoroughly updated for use ...

  12. Advanced finite element technologies

    CERN Document Server

    Wriggers, Peter

    2016-01-01

    The book presents an overview of the state of research of advanced finite element technologies. Besides the mathematical analysis, the finite element development and their engineering applications are shown to the reader. The authors give a survey of the methods and technologies concerning efficiency, robustness and performance aspects. The book covers the topics of mathematical foundations for variational approaches and the mathematical understanding of the analytical requirements of modern finite element methods. Special attention is paid to finite deformations, adaptive strategies, incompressible, isotropic or anisotropic material behavior and the mathematical and numerical treatment of the well-known locking phenomenon. Beyond that new results for the introduced approaches are presented especially for challenging nonlinear problems.

  13. Identifying and Leveraging Trust as a Key Element in the Development, Implementation and Sustainment of the Salt Lake City Fire Department’s Intelligence Program

    Science.gov (United States)

    2014-09-01

    Disentanglement and Protest Deterrence Training, which consisted of didactic and tactical training programs and had built several working relationships with...This program also includes joint training, both didactic and tactile, taking this network development to a higher level by improving the mutual...the book , From Good to Great, Jim Collins wrote a chapter called, First Who…Then What.152 The significant finding of his research on the core of

  14. Multimodal transportation best practices and model element.

    Science.gov (United States)

    2014-06-01

    This report provides guidance in developing a multimodal transportation element of a local government comprehensive : plan. Two model elements were developed to address differences in statutory requirements for communities of different : sizes and pl...

  15. Design study of RL10 derivatives. Volume 3, part 2: Operational and flight support plan. [analysis of transportation requirements for rocket engine in support of space tug program

    Science.gov (United States)

    Shubert, W. C.

    1973-01-01

    Transportation requirements are considered during the engine design layout reviews and maintenance engineering analyses. Where designs cannot be influenced to avoid transportation problems, the transportation representative is advised of the problems permitting remedies early in the program. The transportation representative will monitor and be involved in the shipment of development engine and GSE hardware between FRDC and vehicle manufacturing plant and thereby will be provided an early evaluation of the transportation plans, methods and procedures to be used in the space tug support program. Unanticipated problems discovered in the shipment of development hardware will be known early enough to permit changes in packaging designs and transportation plans before the start of production hardware and engine shipments. All conventional transport media can be used for the movement of space tug engines. However, truck transport is recommended for ready availability, variety of routes, short transit time, and low cost.

  16. The VERCORS safety program, source term analytical study with special emphasis on the release of non volatile fission products and transuranic elements

    Energy Technology Data Exchange (ETDEWEB)

    Ducros, G.; Andre, B.; Tourasse, M. [CEA Centre d`Etudes de Grenoble, 38 (France). Direction des Technologies Avancees; Maro, D. [CEA Centre d`Etudes de Fontenay-aux-Roses, 92 (France). Inst. de Protection et de Surete Nucleaire

    1995-12-31

    This document is not a true report but the succession of transparencies listing the main titles of subjects that have been developed in oral form at CSARP Meeting. The main interest of the document is in large computer designed figures. The subject is the VERCORS program (which extends the HEVA experimental program) devoted to the determination of the source term of fission products released from PWR fuel samples during a severe accident sequence. The experiment is performed in a shielded hot cell at CEA Grenoble plant. Measurements aimed at characterizing fission products releases and structural materials as a function of fuel temperature and oxidising / reducing conditions of the environment. (author).

  17. Results of the monitoring program at the factory site of fuel elements Juzbado; Resultados del programa vigilancia del emplazamiento en la fabrica de elementos combustibles de Juzbado

    Energy Technology Data Exchange (ETDEWEB)

    Ortiz Trujillo, D.; Perez Fonseca, A.; Sierra Gil, S.

    2011-07-01

    The factory fuel elements Juzbado has a number of unique features different from other nuclear facilities, given that the inventory of isotopes present in Juzbado limited to uranium enriched to 5% and their descendants, all these isotopes are normally in the nature in various amounts depending on the hydrogeological area. For this reason, it should be noted that quantification of contamination provided can be complicated to be able to find the same isotopes in the natural background radiation, having to have clear criteria and appropriate methodology for distinguishing background values ??due to the factory values . In this paper we will explain the results of the inspection plan.

  18. Standard requirement of a microbiological quality control program for the manufacture of human mesenchymal stem cells for clinical use.

    Science.gov (United States)

    Gálvez, Patricia; Clares, Beatriz; Bermejo, Maria; Hmadcha, Abdelkrim; Soria, Bernat

    2014-05-15

    The manufacturing of human mesenchymal stem cells (hMSCs) as cell-based products for clinical use should be performed with appropriate controls that ensure its safety and quality. The use of hMSCs in cell therapy has increased considerably in the past few years. In line with this, the assessment and management of contamination risks by microbial agents that could affect the quality of cells and the safety of patients have to be considered. It is necessary to implant a quality control program (QCP) covering the entire procedure of the ex vivo expansion, from the source of cells, starting materials, and reagents, such as intermediate products, to the final cellular medicine. We defined a QCP to detect microbiological contamination during manufacturing of autologous hMSCs for clinical application. The methods used include sterility test, Gram stain, detection of mycoplasma, endotoxin assay, and microbiological monitoring in process according to the European Pharmacopoeia (Ph. Eur.) and each analytical technique was validated in accordance with three different cell cultures. Results showed no microbiological contamination in any phases of the cultures, meeting all the acceptance criteria for sterility test, detection of mycoplasma and endotoxin, and environmental and staff monitoring. Each analytical technique was validated demonstrating the sensitivity, limit of detection, and robustness of the method. The quality and safety of MSCs must be controlled to ensure their final use in patients. The evaluation of the proposed QCP revealed satisfactory results in order to standardize this procedure for clinical use of cells.

  19. U.S. aerospace industry opinion of the effect of computer-aided prediction-design technology on future wind-tunnel test requirements for aircraft development programs

    Science.gov (United States)

    Treon, S. L.

    1979-01-01

    A survey of the U.S. aerospace industry in late 1977 suggests that there will be an increasing use of computer-aided prediction-design technology (CPD Tech) in the aircraft development process but that, overall, only a modest reduction in wind-tunnel test requirements from the current level is expected in the period through 1995. Opinions were received from key spokesmen in 23 of the 26 solicited major companies or corporate divisions involved in the design and manufacture of nonrotary wing aircraft. Development programs for nine types of aircraft related to test phases and wind-tunnel size and speed range were considered.

  20. Policies and practices pertaining to the selection, qualification requirements, and training programs for nuclear-reactor operating personnel at the Oak Ridge National Laboratory

    Energy Technology Data Exchange (ETDEWEB)

    Culbert, W.H.

    1985-10-01

    This document describes the policies and practices of the Oak Ridge National Laboratory (ORNL) regarding the selection of and training requirements for reactor operating personnel at the Laboratory's nuclear-reactor facilities. The training programs, both for initial certification and for requalification, are described and provide the guidelines for ensuring that ORNL's research reactors are operated in a safe and reliable manner by qualified personnel. This document gives an overview of the reactor facilities and addresses the various qualifications, training, testing, and requalification requirements stipulated in DOE Order 5480.1A, Chapter VI (Safety of DOE-Owned Reactors); it is intended to be in compliance with this DOE Order, as applicable to ORNL facilities. Included also are examples of the documentation maintained amenable for audit.

  1. Error-controlled adaptive finite elements in solid mechanics

    National Research Council Canada - National Science Library

    Stein, Erwin; Ramm, E

    2003-01-01

    ... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Error-controlled Adaptive Finite-element-methods . . . . . . . . . . . . Missing Features and Properties of Today's General Purpose FE Programs for Structural...

  2. National School Lunch Program and School Breakfast Program: Nutrition Standards for All Foods Sold in School as Required by the Healthy, Hunger-Free Kids Act of 2010. Final rule and interim final rule.

    Science.gov (United States)

    2016-07-29

    This rule adopts as final, with some modifications, the National School Lunch Program and School Breakfast Program regulations set forth in the interim final rule published in the Federal Register on June 28, 2013. The requirements addressed in this rule conform to the provisions in the Healthy, Hunger-Free Kids Act of 2010 regarding nutrition standards for all foods sold in schools, other than food sold under the lunch and breakfast programs. Most provisions of this final rule were implemented on July 1, 2014, a full year subsequent to publication of the interim final rule. This was in compliance with section 208 of the Healthy, Hunger-Free Kids Act of 2010, which required that State and local educational agencies have at least one full school year from the date of publication of the interim final rule to implement the competitive food provisions. Based on comments received on the interim final rule and implementation experience, this final rule makes a few modifications to the nutrition standards for all foods sold in schools implemented on July 1, 2014. In addition, this final rule codifies specific policy guidance issued after publication of the interim rule. Finally, this rule retains the provision related to the standard for total fat as interim and requests further comment on this single standard.

  3. Are All Program Elements Created Equal? Relations Between Specific Social and Emotional Learning Components and Teacher-Student Classroom Interaction Quality.

    Science.gov (United States)

    Abry, Tashia; Rimm-Kaufman, Sara E; Curby, Timothy W

    2017-02-01

    School-based social and emotional learning (SEL) programs are presented to educators with little understanding of the program components that have the greatest leverage for improving targeted outcomes. Conducted in the context of a randomized controlled trial, the present study used variation in treatment teachers' (N = 143) implementation of four core components of the Responsive Classroom approach to examine relations between each component and the quality of teachers' emotional, organizational, and instructional interactions in third, fourth, and fifth grade classrooms (controlling for pre-intervention interaction quality and other covariates). We also examined the extent to which these relations varied as a function of teachers' baseline levels of interaction quality. Indices of teachers' implementation of Morning Meeting, Rule Creation, Interactive Modeling, and Academic Choice were derived from a combination of teacher-reported surveys and classroom observations. Ratings of teacher-student classroom interactions were aggregated across five observations conducted throughout the school year. Structural path models indicated that teachers' use of Morning Meeting and Academic Choice related to higher levels of emotionally supportive interactions; Academic Choice also related to higher levels of instructional interactions. In addition, teachers' baseline interaction quality moderated several associations such that the strongest relations between RC component use and interaction quality emerged for teachers with the lowest baseline interaction quality. Results highlight the value of examining individual program components toward the identification of program active ingredients that can inform intervention optimization and teacher professional development.

  4. High Specificity in Circulating Tumor Cell Identification Is Required for Accurate Evaluation of Programmed Death-Ligand 1.

    Directory of Open Access Journals (Sweden)

    Jennifer L Schehr

    Full Text Available Expression of programmed-death ligand 1 (PD-L1 in non-small cell lung cancer (NSCLC is typically evaluated through invasive biopsies; however, recent advances in the identification of circulating tumor cells (CTCs may be a less invasive method to assay tumor cells for these purposes. These liquid biopsies rely on accurate identification of CTCs from the diverse populations in the blood, where some tumor cells share characteristics with normal blood cells. While many blood cells can be excluded by their high expression of CD45, neutrophils and other immature myeloid subsets have low to absent expression of CD45 and also express PD-L1. Furthermore, cytokeratin is typically used to identify CTCs, but neutrophils may stain non-specifically for intracellular antibodies, including cytokeratin, thus preventing accurate evaluation of PD-L1 expression on tumor cells. This holds even greater significance when evaluating PD-L1 in epithelial cell adhesion molecule (EpCAM positive and EpCAM negative CTCs (as in epithelial-mesenchymal transition (EMT.To evaluate the impact of CTC misidentification on PD-L1 evaluation, we utilized CD11b to identify myeloid cells. CTCs were isolated from patients with metastatic NSCLC using EpCAM, MUC1 or Vimentin capture antibodies and exclusion-based sample preparation (ESP technology.Large populations of CD11b+CD45lo cells were identified in buffy coats and stained non-specifically for intracellular antibodies including cytokeratin. The amount of CD11b+ cells misidentified as CTCs varied among patients; accounting for 33-100% of traditionally identified CTCs. Cells captured with vimentin had a higher frequency of CD11b+ cells at 41%, compared to 20% and 18% with MUC1 or EpCAM, respectively. Cells misidentified as CTCs ultimately skewed PD-L1 expression to varying degrees across patient samples.Interfering myeloid populations can be differentiated from true CTCs with additional staining criteria, thus improving the

  5. Impact of requiring influenza vaccination for children in licensed child care or preschool programs--Connecticut, 2012-13 influenza season.

    Science.gov (United States)

    Hadler, James L; Yousey-Hindes, Kimberly; Kudish, Kathy; Kennedy, Erin D; Sacco, Vincent; Cartter, Matthew L

    2014-03-07

    Preschool-aged children are at increased risk for severe influenza-related illness and complications. Congregate child care settings facilitate influenza transmission among susceptible children. To protect against influenza transmission in these settings, in September 2010, Connecticut became the second U.S. state (after New Jersey) to implement regulations requiring that all children aged 6-59 months receive at least 1 dose of influenza vaccine each year to attend a licensed child care program. To evaluate the impact of this regulation on vaccination levels and influenza-associated hospitalizations during the 2012-13 influenza season, vaccination data from U.S. and Connecticut surveys and the Emerging Infections Program (EIP) were analyzed. After the regulation took effect, vaccination rates among Connecticut children aged 6-59 months increased from 67.8% during the 2009-10 influenza season to 84.1% during the 2012-13 season. During the 2012-13 influenza season, among all 11 EIP surveillance sites, Connecticut had the greatest percentage decrease (12%) in the influenza-associated hospitalization rate from 2007-08 among children aged ≤4 years. Additionally, the ratio of the influenza-associated hospitalization rates among children aged ≤4 years to the overall population rate (0.53) was lower than for any other EIP site. Requiring vaccination for child care admission might have helped to increase vaccination rates in Connecticut and reduced serious morbidity from influenza.

  6. Teaching Explicitly and Reflecting on Elements of Nature of Science: a Discourse-Focused Professional Development Program with Four Fifth-Grade Teachers

    Science.gov (United States)

    Piliouras, Panagiotis; Plakitsi, Katerina; Seroglou, Fanny; Papantoniou, Georgia

    2017-06-01

    The nature of science (NOS) has become a central goal of science education in many countries. This study refers to a developmental work research program, in which four fifth-grade elementary in-service teachers participated. It aimed to improve their understandings of NOS and their abilities to teach it effectively to their students. The 1-year-long, 2012-2013, program consisted of a series of activities to support teachers to develop their pedagogical content knowledge of NOS. In order to accomplish our goal, we enabled teacher-researchers to analyze their own discourse practices and to trace evidence of effective NOS teaching. Many studies indicate the importance of examining teachers' discussions about science in the classroom, since it is teachers' understanding of NOS reflected in these discussions that will have a vital impact on students' learning. Our proposal is based on the assumption that reflecting on the ways people form meanings enables us to examine and seek alternative ways to communicate aspects of NOS during science lessons. The analysis of discourse data, which has been carried out with the teacher-researchers' active participation, indicated that initially only a few aspects of NOS were implicitly incorporated in teacher-researchers' instruction. As the program evolved, all teacher-researchers presented more informed views on targeted NOS aspects. On the whole, our discourse-focused professional development program with its participatory, explicit, and reflective character indicated the importance of involving teacher-researchers in analyzing their own talk. It is this involvement that results in obtaining a valuable awareness of aspects concerning pedagogical content knowledge of NOS teaching.

  7. A novel sterol regulatory element-binding protein gene (sreA identified in penicillium digitatum is required for prochloraz resistance, full virulence and erg11 (cyp51 regulation.

    Directory of Open Access Journals (Sweden)

    Jing Liu

    Full Text Available Penicillium digitatum is the most destructive postharvest pathogen of citrus fruits, causing fruit decay and economic loss. Additionally, control of the disease is further complicated by the emergence of drug-resistant strains due to the extensive use of triazole antifungal drugs. In this work, an orthologus gene encoding a putative sterol regulatory element-binding protein (SREBP was identified in the genome of P. digitatum and named sreA. The putative SreA protein contains a conserved domain of unknown function (DUF2014 at its carboxyl terminus and a helix-loop-helix (HLH leucine zipper DNA binding domain at its amino terminus, domains that are functionally associated with SREBP transcription factors. The deletion of sreA (ΔsreA in a prochloraz-resistant strain (PdHS-F6 by Agrobacterium tumefaciens-mediated transformation led to increased susceptibility to prochloraz and a significantly lower EC50 value compared with the HS-F6 wild-type or complementation strain (COsreA. A virulence assay showed that the ΔsreA strain was defective in virulence towards citrus fruits, while the complementation of sreA could restore the virulence to a large extent. Further analysis by quantitative real-time PCR demonstrated that prochloraz-induced expression of cyp51A and cyp51B in PdHS-F6 was completely abolished in the ΔsreA strain. These results demonstrate that sreA is a critical transcription factor gene required for prochloraz resistance and full virulence in P. digitatum and is involved in the regulation of cyp51 expression.

  8. 3'UTR AU-Rich Elements (AREs) and the RNA-Binding Protein Tristetraprolin (TTP) Are Not Required for the LPS-Mediated Destabilization of Phospholipase-Cβ-2 mRNA in Murine Macrophages.

    Science.gov (United States)

    Shukla, Smita; Elson, Genie; Blackshear, Perry J; Lutz, Carol S; Leibovich, S Joseph

    2017-04-01

    We have shown previously that bacterial lipopolysaccharide (LPS)-mediated suppression of phospholipase-Cβ-2 (PLCβ-2) expression is involved in M1 (inflammatory) to M2-like (wound healing) phenotypic switching of macrophages triggered by adenosine. This suppression is mediated post-transcriptionally by destabilization of PLCβ-2 mRNA (messenger ribonucleic acid). To investigate the mechanism of this LPS-mediated destabilization, we examined the roles of RNA-binding agents including microRNAs and RNA-binding proteins that are involved in regulating stability of mRNAs encoding growth factors, inflammatory mediators, and proto-oncogenes. Adenylate and uridylate (AU)-rich elements (AREs) in 3'UTRs are specific recognition sites for RNA-binding proteins including tristetraprolin (TTP), HuR, and AUF1 and for microRNAs that are involved in regulating mRNA stability. In this study, we investigated the role of TTP and AREs in regulating PLCβ-2 mRNA stability. The 3'UTR of the PLCβ-2 gene was inserted into the pLightswitch luciferase reporter plasmid and transfected into RAW264.7 cells. LPS suppressed luciferase expression from this reporter. Luciferase expression from mutant 3'UTR constructs lacking AREs was similarly downregulated, suggesting that these regions are not required for LPS-mediated suppression of PLCβ-2. TTP was rapidly upregulated in both primary murine macrophages and RAW264.7 cells in response to LPS. Suppression of PLCβ-2 by LPS was examined using macrophages from mice lacking TTP (TTP(-/-)). LPS suppressed PLCβ-2 expression to the same extent in wild type (WT) and TTP(-/-) macrophages. Also, the rate of decay of PLCβ-2 mRNA in LPS-treated macrophages following transcriptional blockade was similar in WT and TTP(-/-) macrophages, clearly indicating that TTP is not involved in LPS-mediated destabilization of PLCβ-2 mRNA in macrophages.

  9. Identification of the critical sequence elements in the cytoplasmic domain of leptin receptor isoforms required for Janus kinase/signal transducer and activator of transcription activation by receptor heterodimers.

    Science.gov (United States)

    Bahrenberg, Gregor; Behrmann, Iris; Barthel, Andreas; Hekerman, Paul; Heinrich, Peter Claus; Joost, Hans-Georg; Becker, Walter

    2002-04-01

    Two predominant splice variants of the leptin receptor (LEPR) are coexpressed in leptin-responsive tissues: the long form, LEPRb, characterized as the signal-transducing receptor, and the signaling-defective short form, LEPRa. It is unknown whether heterodimers of these isoforms are capable of signal transduction via the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway. To address this question, chimeric receptors were constructed consisting of the transmembrane and intracellular parts of LEPRb and LEPRa fused with the extracellular domains of either the alpha- or beta-subunit of the IL-5 receptor. This strategy allows the directed heterodimerization of different LEPR cytoplasmic tails and excludes homodimerization. In COS-7 and HEPG2 cells, chimeric receptor heterodimers of LEPRa and LEPRb failed to activate the JAK/STAT pathway, whereas receptor dimers of LEPRb gave rise to the expected ligand-dependent activation of JAK2, phosphorylation of STAT3, and STAT3-dependent promoter activity. Markedly lower amounts of JAK2 were found to be associated with immunoprecipitated LEPRa chimeras than with LEPRb chimeras. Analysis of a series of deletion constructs indicated that a segment of 15 amino acids in addition to the 29 amino acids common to LEPRa and LEPRb was required for partial restoration of JAK/STAT activation. Site-directed mutagenesis of the critical sequence indicated that two hydrophobic residues (Leu896, Phe897) not present in LEPRa were indispensable for receptor signaling. These findings show that LEPRa/LEPRb heterodimers cannot activate STAT3 and identify sequence elements within the LEPR that are critical for the activation of JAK2 and STAT3.

  10. Byproduct metals and rare-earth elements used in the production of light-emitting diodes—Overview of principal sources of supply and material requirements for selected markets

    Science.gov (United States)

    Wilburn, David R.

    2012-01-01

    The use of light-emitting diodes (LEDs) is expanding because of environmental issues and the efficiency and cost savings achieved compared with use of traditional incandescent lighting. The longer life and reduced power consumption of some LEDs have led to annual energy savings, reduced maintenance costs, and lower emissions of carbon dioxide, sulfur dioxide, and nitrogen oxides from powerplants because of the resulting decrease in energy consumption required for lighting applications when LEDs are used to replace less-energy-efficient sources. Metals such as arsenic, gallium, indium, and the rare-earth elements (REEs) cerium, europium, gadolinium, lanthanum, terbium, and yttrium are important mineral materials used in LED semiconductor technology. Most of the world's supply of these materials is produced as byproducts from the production of aluminum, copper, lead, and zinc. Most of the rare earths required for LED production in 2011 came from China, and most LED production facilities were located in Asia. The LED manufacturing process is complex and is undergoing much change with the growth of the industry and the changes in demand patterns of associated commodities. In many respects, the continued growth of the LED industry, particularly in the general lighting sector, is tied to its ability to increase LED efficiency and color uniformity while decreasing the costs of producing, purchasing, and operating LEDs. Research is supported by governments of China, the European Union, Japan, the Republic of Korea, and the United States. Because of the volume of ongoing research in this sector, it is likely that the material requirements of future LEDs may be quite different than LEDs currently (2011) in use as industry attempts to cut costs by reducing material requirements of expensive heavy rare-earth phosphors and increasing the sizes of wafers for economies of scale. Improved LED performance will allow customers to reduce the number of LEDs in automotive, electronic

  11. GAUSSIAN BEAM LASER RESONATOR PROGRAM

    Science.gov (United States)

    Cross, P. L.

    1994-01-01

    In designing a laser cavity, the laser engineer is frequently concerned with more than the stability of the resonator. Other considerations include the size of the beam at various optical surfaces within the resonator or the performance of intracavity line-narrowing or other optical elements. Laser resonators obey the laws of Gaussian beam propagation, not geometric optics. The Gaussian Beam Laser Resonator Program models laser resonators using Gaussian ray trace techniques. It can be used to determine the propagation of radiation through laser resonators. The algorithm used in the Gaussian Beam Resonator program has three major components. First, the ray transfer matrix for the laser resonator must be calculated. Next calculations of the initial beam parameters, specifically, the beam stability, the beam waist size and location for the resonator input element, and the wavefront curvature and beam radius at the input surface to the first resonator element are performed. Finally the propagation of the beam through the optical elements is computed. The optical elements can be modeled as parallel plates, lenses, mirrors, dummy surfaces, or Gradient Index (GRIN) lenses. A Gradient Index lens is a good approximation of a laser rod operating under a thermal load. The optical system may contain up to 50 elements. In addition to the internal beam elements the optical system may contain elements external to the resonator. The Gaussian Beam Resonator program was written in Microsoft FORTRAN (Version 4.01). It was developed for the IBM PS/2 80-071 microcomputer and has been implemented on an IBM PC compatible under MS DOS 3.21. The program was developed in 1988 and requires approximately 95K bytes to operate.

  12. Framed primal elements

    OpenAIRE

    Debongnie, Jean-François

    1986-01-01

    Framed primal finite elements may be viewed as a generalized class of elements including conforming elements, primal hybrids, and non concorming elements passing the patch test. This systematization is illustrated on a lot of examples.

  13. Associations between statewide prescription drug monitoring program (PDMP) requirement and physician patterns of prescribing opioid analgesics for patients with non-cancer chronic pain.

    Science.gov (United States)

    Lin, Hsien-Chang; Wang, Zhi; Boyd, Carol; Simoni-Wastila, Linda; Buu, Anne

    2018-01-01

    State-level prescription drug monitoring programs (PDMPs) have been implemented in most states. PDMPs enable registered prescribers to obtain real-time information on patients' prescription history to reduce non-medical use of controlled drugs. This study examined whether PDMP implementation and different levels of PDMP requirements were associated with physicians' patterns of prescribing opioid analgesics for patients with non-cancer chronic pain. This is a secondary analysis study using cross-sectional national data. Patients with non-cancer chronic pain from the 2012 National Ambulatory Medical Care Survey were included (weighted N=81,018,131; unweighted N=3295). Heckman two-step selection procedure employing two logistic regressions was used to explore the associations between PDMP requirements and physicians' prescribing behaviors, controlling for physician characteristics, patient characteristics, physician-healthcare system interaction, and physician-patient relationship, guided by the Eisenberg's model of physician decision making. State PDMP implementation status and requirement levels were not associated with physician opioid prescribing for non-cancer chronic pain treatment (p's ranged 0.30-0.32). Patients with Medicare coverage were more likely to be prescribed opioid analgesics than those with private health insurance (OR=1.55, popioid analgesics than non-Hispanic white patients (OR=0.61, popioid prescribing tendency for non-cancer chronic pain treatment could not be supported. Policy makers should be aware of the need for redesigning PDMPs regarding requirements and enforcement for prescribers and related stakeholders. Future studies also are needed to identify characteristics contributing to PDMP effectiveness in reducing non-medical use of prescription opioids. Copyright © 2017 Elsevier Ltd. All rights reserved.

  14. Chemical Elements Bingo

    Science.gov (United States)

    Tejeda, Silvia; Palacios, Joaquin

    1995-12-01

    An important part of the high school chemistry program is the topic of periodic classification and periodicity. We have observed that one of the obstacles for the study of the matter is the new vocabulary necessary to initiate this work. Our students have to understand that the periodic classification is an orderly way of presenting the elements and its properties, they compare the table with other classification systems that they already know, nevertheless for the average student it is difficult to deduce or predict properties with periodic classification. As an example of this concept, we can point out the electronic configuration, atomic radii, oxidation state, and valence number. In order to facilitate the learning-teaching process of this topic in high school level, we stimulate the class to play with the periodic table, to get familiar with the general concepts of periodicity. We started our work dealing with the most common elements in each group. Chemical Elements Bingo (CEB) is a game we designed to teach periodic classification.

  15. Development of a quality assurance program for ionizing radiation secondary calibration laboratories

    Energy Technology Data Exchange (ETDEWEB)

    Heaton, H.T. II; Taylor, A.R. Jr. [Center for Devices and Radiological Health, Rockville, MD (United States)

    1993-12-31

    For calibration laboratories, routine calibrations of instruments meeting stated accuracy goals are important. One method of achieving the accuracy goals is to establish and follow a quality assurance program designed to monitor all aspects of the calibration program and to provide the appropriate feedback mechanism if adjustments are needed. In the United States there are a number of organizations with laboratory accreditation programs. All existing accreditation programs require that the laboratory implement a quality assurance program with essentially the same elements in all of these programs. Collectively, these elements have been designated as a Measurement Quality Assurance (MQA) program. This paper will briefly discuss the interrelationship of the elements of an MQA program. Using the Center for Devices and Radiological Health (CDRH) X-ray Calibration Laboratory (XCL) as an example, it will focus on setting up a quality control program for the equipment in a Secondary Calibration Laboratory.

  16. Methane Propulsion Elements for Mars

    Science.gov (United States)

    Percy, Tom; Polsgrove, Tara; Thomas, Dan

    2017-01-01

    Human exploration beyond LEO relies on a suite of propulsive elements to: (1) Launch elements into space, (2) Transport crew and cargo to and from various destinations, (3) Provide access to the surface of Mars, (4) Launch crew from the surface of Mars. Oxygen/Methane propulsion systems meet the unique requirements of Mars surface access. A common Oxygen/Methane propulsion system is being considered to reduce development costs and support a wide range of primary & alternative applications.

  17. 1:1 Device Programs Best Practices in K-12 Education: Fiscal Year 2016 Report to the Legislature. As Required by Minnesota 2015 Special Session Law, House File 1, Article 6, Section 8

    Science.gov (United States)

    Minnesota Department of Education, 2016

    2016-01-01

    As required by Minnesota 2015 Special Session Law, House File 1, Article 6, Section 8, the commissioner of Education must research existing one device to one student (1:1) device programs in Minnesota and across the country to determine best practices for Minnesota schools implementing 1:1 device programs. The commissioner must develop and publish…

  18. Measurement of functional capacity requirements to aid in development of an occupation-specific rehabilitation training program to help firefighters with cardiac disease safely return to work.

    Science.gov (United States)

    Adams, Jenny; Roberts, Joanne; Simms, Kay; Cheng, Dunlei; Hartman, Julie; Bartlett, Charles

    2009-03-15

    We designed a study to measure the functional capacity requirements of firefighters to aid in the development of an occupation-specific training program in cardiac rehabilitation; 23 healthy male firefighters with no history of heart disease completed a fire and rescue obstacle course that simulated 7 common firefighting tasks. They wore complete personal protective equipment and portable metabolic instruments that included a data collection mask. We monitored each subject's oxygen consumption (VO(2)) and working heart rate, then calculated age-predicted maximum heart rates (220 - age) and training target heart rates (85% of age-predicted maximum heart rate). During performance of the obstacle course, the subjects' mean working heart rates and peak heart rates were higher than the calculated training target heart rates (t(22) = 5.69 [working vs target, p <0.001] and t(22) = 15.14 [peak vs target, p <0.001]). These findings, with mean results for peak VO(2) (3,447 ml/min) and metabolic equivalents (11.9 METs), show that our subjects' functional capacity greatly exceeded that typically attained by patients in traditional cardiac rehabilitation programs (5 to 8 METs). In conclusion, our results indicate the need for intense, occupation-specific cardiac rehabilitation training that will help firefighters safely return to work after a cardiac event.

  19. Analytical elements of mechanics

    CERN Document Server

    Kane, Thomas R

    2013-01-01

    Analytical Elements of Mechanics, Volume 1, is the first of two volumes intended for use in courses in classical mechanics. The books aim to provide students and teachers with a text consistent in content and format with the author's ideas regarding the subject matter and teaching of mechanics, and to disseminate these ideas. The book opens with a detailed exposition of vector algebra, and no prior knowledge of this subject is required. This is followed by a chapter on the topic of mass centers, which is presented as a logical extension of concepts introduced in connection with centroids. A

  20. James Webb Space Telescope Optical Telescope Element Mirror Coatings

    Science.gov (United States)

    Keski-Kuha, Ritva A.; Bowers, Charles W.; Quijada, Manuel A.; Heaney, James B.; Gallagher, Benjamin; McKay, Andrew; Stevenson, Ian

    2012-01-01

    James Webb Space Telescope (JWST) Optical Telescope Element (OTE) mirror coating program has been completed. The science goals of the JWST mission require a uniform, low stress, durable optical coating with high reflectivity over the JWST spectral region. The coating has to be environmentally stable, radiation resistant and compatible with the cryogenic operating environment. The large size, 1.52 m point to point, light weight, beryllium primary mirror (PM) segments and flawless coating process during the flight mirror coating program that consisted coating of 21 flight mirrors were among many technical challenges. This paper provides an overview of the JWST telescope mirror coating program. The paper summarizes the coating development program and performance of the flight mirrors.