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Sample records for program analysis opa

  1. Spatio-temporal analysis of landuse dynamics in Upper Opa ...

    African Journals Online (AJOL)

    This study explored the use of geospatial techniques to assess land use change within upper Opa catchment area in Ile-Ife, Osun State, Nigeria for a period of 28 years between 1986 and 2014. To accomplish this, Landsat TM 1986, ETM 2002 and OLI 2014 were acquired from the USGS Earth Explorer in Global Land ...

  2. Association of OPA1 polymorphisms with NTG and HTG: a meta-analysis.

    Directory of Open Access Journals (Sweden)

    Yatu Guo

    Full Text Available BACKGROUND: Genetic polymorphisms of the Optic atrophy 1 gene have been implicated in altering the risk of primary open angle glaucoma (POAG, especially the susceptibility to normal tension glaucoma (NTG, but the results remain controversial. METHODS: Multiple electronic databases (up to January 20, 2012 were searched independently by two investigators. A meta-analysis was performed on the association between Optic atrophy 1 polymorphisms (rs 166850 and rs 10451941 and normal tension glaucoma (NTG/high tension glaucoma (HTG. Summary odds ratios (ORs and 95% confidence intervals (CI were estimated. RESULTS: Seven studies of 713 cases and 964 controls for NTG and five studies of 1200 cases and 971 controls for HTG on IVS8+4C>T (rs 166850 and IVS8+32T>C (rs10451941 were identified. There were significant associations between the OPA1 rs10451941polymorphism and NTG susceptibility for all genetic models(C vs. T OR = 1.26, 95% CI 1.09-1.47, p = 0.002; CC vs. TT: OR = 1.52, 95% CI 1.04-2.20, p = 0.029; CC vs. CT+TT: OR = 1.64, 95% CI 1.16-2.33, p = 0.005; CC+CT vs. TT: OR = 1.21, 95% CI 1.02-1.44, p = 0.032. However, no evidence of associations was detected between the OPA1 IVS8+32C>T polymorphism and POAG susceptibility to HTG. Similarly, clear associations between the rs 166850 variant and NTG were observed in allelic and dominant models (T vs. C OR = 1.52, 95% CI 1.16-1.99, p = 0.002; TT+TC vs. CC OR = 1.50, 95% CI 1.13-2.01, p = 0.006 but not to HTG. In subgroup analyses by ethnicity, we detected an association between both OPA1 polymorphisms and risk for NTG in Caucasians but not in Asians. By contrast, no significant findings were noted between OPA1 variants for HTG, either in Caucasians or in Asians. CONCLUSIONS: Both the IVS8+4C>T and IVS8+32T>C variants may affect individual susceptibility to NTG. Moreover, stratified analyses for NTG detecting the effects of both OPA1 polymorphisms seemed to vary with ethnicity. Further investigations are

  3. Association of OPA1 polymorphisms with NTG and HTG: a meta-analysis.

    Science.gov (United States)

    Guo, Yatu; Chen, Xia; Zhang, Hongtuan; Li, Ningdong; Yang, Xiong; Cheng, Wenbo; Zhao, Kanxing

    2012-01-01

    Genetic polymorphisms of the Optic atrophy 1 gene have been implicated in altering the risk of primary open angle glaucoma (POAG), especially the susceptibility to normal tension glaucoma (NTG), but the results remain controversial. Multiple electronic databases (up to January 20, 2012) were searched independently by two investigators. A meta-analysis was performed on the association between Optic atrophy 1 polymorphisms (rs 166850 and rs 10451941) and normal tension glaucoma (NTG)/high tension glaucoma (HTG). Summary odds ratios (ORs) and 95% confidence intervals (CI) were estimated. Seven studies of 713 cases and 964 controls for NTG and five studies of 1200 cases and 971 controls for HTG on IVS8+4C>T (rs 166850) and IVS8+32T>C (rs10451941) were identified. There were significant associations between the OPA1 rs10451941polymorphism and NTG susceptibility for all genetic models(C vs. T OR = 1.26, 95% CI 1.09-1.47, p = 0.002; CC vs. TT: OR = 1.52, 95% CI 1.04-2.20, p = 0.029; CC vs. CT+TT: OR = 1.64, 95% CI 1.16-2.33, p = 0.005; CC+CT vs. TT: OR = 1.21, 95% CI 1.02-1.44, p = 0.032). However, no evidence of associations was detected between the OPA1 IVS8+32C>T polymorphism and POAG susceptibility to HTG. Similarly, clear associations between the rs 166850 variant and NTG were observed in allelic and dominant models (T vs. C OR = 1.52, 95% CI 1.16-1.99, p = 0.002; TT+TC vs. CC OR = 1.50, 95% CI 1.13-2.01, p = 0.006) but not to HTG. In subgroup analyses by ethnicity, we detected an association between both OPA1 polymorphisms and risk for NTG in Caucasians but not in Asians. By contrast, no significant findings were noted between OPA1 variants for HTG, either in Caucasians or in Asians. Both the IVS8+4C>T and IVS8+32T>C variants may affect individual susceptibility to NTG. Moreover, stratified analyses for NTG detecting the effects of both OPA1 polymorphisms seemed to vary with ethnicity. Further investigations are needed to validate the association.

  4. Manual de OPAS

    OpenAIRE

    Bonell Colmero, Ramón

    2010-01-01

    "Nos encontramos ante el marco normativo de las ofertas públicas de adquisición, dentro de las operaciones de adquisición de empresas, se estudia la regulación nacional y comunitaria, para homogeneizar las normas de los Estados miembros, la UE aprueba en 2004, la Directiva de OPA que establece una regulación para los casos de OPA obligatorias de toma de control. Se analizan efectos de la toma de control de la sociedad desde todos los puntos de vista, incluso los mecanismos de reacción ant...

  5. Phase variation of Opa proteins of Neisseria meningitidis and the effects of bacterial transformation.

    Science.gov (United States)

    Sadarangani, Manish; Hoe, Claire J; Makepeace, Katherine; van der Ley, Peter; Pollard, Andrew J

    2016-03-01

    Opa proteins are major proteins involved in meningococcal colonization of the nasopharynx and immune interactions. Opa proteins undergo phase variation (PV) due to the presence of the 5'-CTCTT-3' coding repeat (CR) sequence. The dynamics of PV of meningococcal Opa proteins is unknown. Opa PV, including the effect of transformation on PV, was assessed using a panel of Opa-deficient strains of Neisseria meningitidis. Analysis of Opa expression from UK disease-causing isolates was undertaken. Different opa genes demonstrated variable rates of PV, between 6.4 × 10(-4) and 6.9 × 10(-3) per cell per generation. opa genes with a longer CR tract had a higher rate of PV (r(2) = 0.77, p = 0.1212). Bacterial transformation resulted in a 180-fold increase in PV rate. The majority of opa genes in UK disease isolates (315/463, 68.0%) were in the 'on' phase, suggesting the importance of Opa proteins during invasive disease. These data provide valuable information for the first time regarding meningococcal Opa PV. The presence of Opa PV in meningococcal populations and high expression of Opa among invasive strains likely indicates the importance of this protein in bacterial colonization in the human nasopharynx. These findings have potential implications for development of vaccines derived from meningococcal outer membranes.

  6. Common variants of OPA1 conferring genetic susceptibility to leprosy in Han Chinese from Southwest China.

    Science.gov (United States)

    Xiang, Yang-Lin; Zhang, Deng-Feng; Wang, Dong; Li, Yu-Ye; Yao, Yong-Gang

    2015-11-01

    Leprosy is an ancient chronic infection caused by Mycobacterium leprae. Onset of leprosy was highly affected by host nutritional condition and energy production, (partially) due to genomic loss and parasitic life style of M. leprae. The optic atrophy 1 (OPA1) gene plays an essential role in mitochondria, which function in cellular energy supply and innate immunity. To investigate the potential involvement of OPA1 in leprosy. We analyzed 7 common genetic variants of OPA1 in 1110 Han Chinese subjects with and without leprosy, followed by mRNA expression profiling and protein-protein interaction (PPI) network analysis. We observed positive associations between OPA1 variants rs9838374 (Pgenotypic=0.003) and rs414237 (Pgenotypic=0.002) with lepromatous leprosy. expression quantitative trait loci (eQTL) analysis showed that the leprosy-related risk allele C of rs414237 is correlated with lower OPA1 mRNA expression level. Indeed, we identified a decrease of OPA1 mRNA expression in both with patients and cellular model of leprosy. In addition, the PPI analysis showed that OPA1 protein was actively involved in the interaction network of M. leprae induced differentially expressed genes. Our results indicated that OPA1 variants confer risk of leprosy and may affect OPA1 expression, mitochondrial function and antimicrobial pathways. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  7. Sosiaalisen median opas pienille hotelleille

    OpenAIRE

    Lohtander, Annukka

    2014-01-01

    Tämä työ on produktityyppinen opinnäytetyö, joka koostuu tietoperustasta ja tuotoksesta. Tuotos on sosiaalisen median opas pienille suomalaisille hotelleille. Sosiaalisesta mediasta on tullut osa lähes jokaisen yrityksen toimintaa. Majoitusalalla tärkeimpiä alustoja ovat Facebook, TripAdvisor, Twitter, Foursquare, keskustelufoorumit, blogit sekä kuva- ja videopalvelut. Osassa näistä alustoista on syytä olla mukana niin sisällön tuottajana kuin sen seuraajana ja reagoijanakin. Osa...

  8. OPA1-associated disorders: phenotypes and pathophysiology

    DEFF Research Database (Denmark)

    Amati-Bonneau, Patrizia; Milea, Dan; Bonneau, Dominique

    2009-01-01

    The OPA1 gene, encoding a dynamin-like mitochondrial GTPase, is involved in autosomal dominant optic atrophy (ADOA, OMIM #165500). ADOA, also known as Kjer's optic atrophy, affects retinal ganglion cells and the axons forming the optic nerve, leading to progressive visual loss. OPA1 gene sequencing...

  9. OpaR controls a network of downstream transcription factors in Vibrio parahaemolyticus BB22OP.

    Directory of Open Access Journals (Sweden)

    Alison Kernell Burke

    Full Text Available Vibrio parahaemolyticus is an emerging world-wide human pathogen that is associated with food-borne gastroenteritis when raw or undercooked seafood is consumed. Expression of virulence factors in this organism is modulated by the phenomenon known as quorum sensing, which permits differential gene regulation at low versus high cell density. The master regulator of quorum sensing in V. parahaemolyticus is OpaR. OpaR not only controls virulence factor gene expression, but also the colony and cellular morphology associated with growth on a surface and biofilm formation. Whole transcriptome Next Generation sequencing (RNA-Seq was utilized to determine the OpaR regulon by comparing strains BB22OP (opaR+, LM5312 and BB22TR (∆opaR1, LM5674. This work, using the published V. parahaemolyticus BB22OP genome sequence, confirms and expands upon a previous microarray analysis for these two strains that used an Affymetrix GeneChip designed from the closely related V. parahaemolyticus RIMD2210633 genome sequence. Overall there was excellent correlation between the microarray and RNA-Seq data. Eleven transcription factors under OpaR control were identified by both methods and further confirmed by quantitative reverse transcription PCR (qRT-PCR analysis. Nine of these transcription factors were demonstrated to be direct OpaR targets via in vitro electrophoretic mobility shift assays with purified hexahistidine-tagged OpaR. Identification of the direct and indirect targets of OpaR, including small RNAs, will enable the construction of a network map of regulatory interactions important for the switch between the nonpathogenic and pathogenic states.

  10. A recurrent deletion mutation in OPA1 causes autosomal dominant optic atrophy in a Chinese family

    Science.gov (United States)

    Zhang, Liping; Shi, Wei; Song, Liming; Zhang, Xiao; Cheng, Lulu; Wang, Yanfang; Ge, Xianglian; Li, Wei; Zhang, Wei; Min, Qingjie; Jin, Zi-Bing; Qu, Jia; Gu, Feng

    2014-11-01

    Autosomal dominant optic atrophy (ADOA) is the most frequent form of hereditary optic neuropathy and occurs due to the degeneration of the retinal ganglion cells. To identify the genetic defect in a family with putative ADOA, we performed capture next generation sequencing (CNGS) to screen known retinal disease genes. However, six exons failed to be sequenced by CNGS in optic atrophy 1 gene (OPA1). Sequencing of those exons identified a 4 bp deletion mutation (c.2983-1_2985del) in OPA1. Furthermore, we sequenced the transcripts of OPA1 from the patient skin fibroblasts and found there is six-nucleotide deletion (c.2984-c.2989, AGAAAG). Quantitative-PCR and Western blotting showed that OPA1 mRNA and its protein expression have no obvious difference between patient skin fibroblast and control. The analysis of protein structure by molecular modeling suggests that the mutation may change the structure of OPA1 by formation of an alpha helix protruding into an existing pocket. Taken together, we identified an OPA1 mutation in a family with ADOA by filling the missing CNGS data. We also showed that this mutation affects the structural intactness of OPA1. It provides molecular insights for clinical genetic diagnosis and treatment of optic atrophy.

  11. Increase in Cardiac Ischemia-Reperfusion Injuries in Opa1+/- Mouse Model.

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    Sophie Le Page

    Full Text Available Recent data suggests the involvement of mitochondrial dynamics in cardiac ischemia/reperfusion (I/R injuries. Whilst excessive mitochondrial fission has been described as detrimental, the role of fusion proteins in this context remains uncertain.To investigate whether Opa1 (protein involved in mitochondrial inner-membrane fusion deficiency affects I/R injuries.We examined mice exhibiting Opa1delTTAG mutations (Opa1+/-, showing 70% Opa1 protein expression in the myocardium as compared to their wild-type (WT littermates. Cardiac left-ventricular systolic function assessed by means of echocardiography was observed to be similar in 3-month-old WT and Opa1+/- mice. After subjection to I/R, infarct size was significantly greater in Opa1+/- than in WTs both in vivo (43.2±4.1% vs. 28.4±3.5%, respectively; p<0.01 and ex vivo (71.1±3.2% vs. 59.6±8.5%, respectively; p<0.05. No difference was observed in the expression of other main fission/fusion protein, oxidative phosphorylation, apoptotic markers, or mitochondrial permeability transition pore (mPTP function. Analysis of calcium transients in isolated ventricular cardiomyocytes demonstrated a lower sarcoplasmic reticulum Ca2+ uptake, whereas cytosolic Ca2+ removal from the Na+/Ca2+ exchanger (NCX was increased, whilst SERCA2a, phospholamban, and NCX protein expression levels were unaffected in Opa1+/- compared to WT mice. Simultaneous whole-cell patch-clamp recordings of mitochondrial Ca2+ movements and ventricular action potential (AP showed impairment of dynamic mitochondrial Ca2+ uptake and a marked increase in the AP late repolarization phase in conjunction with greater occurrence of arrhythmia in Opa1+/- mice.Opa1 deficiency was associated with increased sensitivity to I/R, imbalance in dynamic mitochondrial Ca2+ uptake, and subsequent increase in NCX activity.

  12. Transcriptional regulation of opaR, qrr2-4 and aphA by the master quorum-sensing regulator OpaR in Vibrio parahaemolyticus.

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    Yiquan Zhang

    Full Text Available BACKGROUND: Vibrio parahaemolyticus is a leading cause of infectious diarrhea and enterogastritis via the fecal-oral route. V. harveyi is a pathogen of fishes and invertebrates, and has been used as a model for quorum sensing (QS studies. LuxR is the master QS regulator (MQSR of V. harveyi, and LuxR-dependent expression of its own gene, qrr2-4 and aphA have been established in V. harveyi. Molecular regulation of target genes by the V. parahaemolyticus MQSR OpaR is still poorly understood. METHODOLOGY/PRINCIPAL FINDINGS: The bioinformatics analysis indicated that V. parahaemolyticus OpaR, V. harveyi LuxR, V. vulnificu SmcR, and V. alginolyticus ValR were extremely conserved, and that these four MQSRs appeared to recognize the same conserved cis-acting signals, which was represented by the consensus constructs manifesting as a position frequency matrix and as a 20 bp box, within their target promoters. The MQSR box-like sequences were found within the upstream DNA regions of opaR, qrr2-4 and aphA in V. parahaemolyticus, and the direct transcriptional regulation of these target genes by OpaR were further confirmed by multiple biochemical experiments including primer extension assay, gel mobility shift assay, and DNase I footprinting analysis. Translation and transcription starts, core promoter elements for sigma factor recognition, Shine-Dalgarno sequences for ribosome recognition, and OpaR-binding sites were determined for the five target genes of OpaR, which gave a structural map of the OpaR-dependent promoters. Further computational promoter analysis indicated the above regulatory circuits were shared by several other closely related Vibrios but with slight exceptions. CONCLUSIONS/SIGNIFICANCE: This study gave a comprehensive computational and characterization of the direct transcriptional regulation of five target genes, opaR, qrr2-4 and ahpA, by OpaR in V. parahaemolyticus. These characterized regulatory circuits were conserved in V. harveyi

  13. Saattohoito-opas hoitohenkilökunnalle

    OpenAIRE

    Niemi, Marjut

    2013-01-01

    TIIVISTELMÄ Niemi, Marjut. Saattohoito-opas hoitohenkilökunnalle. Diak, kevät 2013, 160 sivua, 11 liitettä. Diakonia-ammattikorkeakoulu. Hoitotyön koulutusohjelma, sairaanhoitaja (AMK) Saattohoito tarkoittaa kuolemaa lähestyvän potilaan hoitoa ja saattohoidossa keskeistä on potilaan oireiden ja kärsimyksen lievittäminen sekä läheisten tukeminen. Kokonaisvaltainen saattohoitotyö ottaa huomioon potilaan fyysiset, psyykkiset, sosiaaliset ja henkiset ja hengelliset tarpeet. Opinn...

  14. Erlebnis Wissenschaft Opa, was macht ein Physiker

    CERN Document Server

    Hess, Siefgried

    2014-01-01

    Im Alter 13 oder 14 Jahren bekam der Autor das Buch Evolution der Physik von Einstein und Infeld in die Hand bekam und versuchte darin zu lesen. Es war nicht fuer Kinder geschrieben, aber ohne dieses Buch waere er wahrscheinlich nicht Physiker geworden. Die Idee zu diesem Manuskript entstand vor ein Paar Jahren, als die Enkelkinder des Autors fragten: "Opa, was erzaehlst du eigentlich den Studenten in deinen Vorlesungen?" Die Intention ist, die "richtige" Physik so zu vermitteln, wie sie Kindern erzaehlt werden kann.Im geschriebenen Text moechtet der Autor auch ein Gefuehl fuer Zahlen und physikalische Einheiten vermitteln, also nicht nur Geschichten, sondern dazwischen auch Fakten und Zahlen.

  15. Phase variation of Opa proteins of Neisseria meningitidis and the ...

    Indian Academy of Sciences (India)

    Bacterial transformation resulted in a 180-fold increase in PV rate. The majority of opagenes in UK disease isolates (315/463, 68.0%) were in the 'on' phase, suggesting the importance of Opa proteins during invasive disease. These data provide valuable information for the first time regarding meningococcal Opa PV.

  16. Reversible optic neuropathy with OPA1 exon 5b mutation

    DEFF Research Database (Denmark)

    Cornille, K.; Milea, D.; Amati-Bonneau, P.

    2008-01-01

    A new c.740G>A (R247H) mutation in OPA1 alternate spliced exon 5b was found in a patient presenting with bilateral optic neuropathy followed by partial, spontaneous visual recovery. R247H fibroblasts from the patient and his unaffected father presented unusual highly tubular mitochondrial network......, significant increased susceptibility to apoptosis, oxidative phosphorylation uncoupling, and altered OPA1 protein profile, supporting the pathogenicity of this mutation. These results suggest that the clinical spectrum of the OPA1-associated optic neuropathies may be larger than previously described......, and that spontaneous recovery may occur in cases harboring an exon 5b mutation Udgivelsesdato: 2008/5...

  17. Deregulation of mitochondria-shaping proteins Opa-1 and Drp-1 in manganese-induced apoptosis.

    Directory of Open Access Journals (Sweden)

    Agustina Alaimo

    Full Text Available Mitochondria are dynamic organelles that undergo fusion and fission processes. These events are regulated by mitochondria-shaping proteins. Changes in the expression and/or localization of these proteins lead to a mitochondrial dynamics impairment and may promote apoptosis. Increasing evidence correlates the mitochondrial dynamics disruption with the occurrence of neurodegenerative diseases. Therefore, we focused on this topic in Manganese (Mn-induced Parkinsonism, a disorder associated with Mn accumulation preferentially in the basal ganglia where mitochondria from astrocytes represent an early target. Using MitoTracker Red staining we observed increased mitochondrial network fission in Mn-exposed rat astrocytoma C6 cells. Moreover, Mn induced a marked decrease in fusion protein Opa-1 levels as well as a dramatic increase in the expression of fission protein Drp-1. Additionally, Mn provoked a significant release of high MW Opa-1 isoforms from the mitochondria to the cytosol as well as an increased Drp-1 translocation to the mitochondria. Both Mdivi-1, a pharmacological Drp-1 inhibitor, and rat Drp-1 siRNA reduced the number of apoptotic nuclei, preserved the mitochondrial network integrity and prevented cell death. CsA, an MPTP opening inhibitor, prevented mitochondrial Δψm disruption, Opa-1 processing and Drp-1 translocation to the mitochondria therefore protecting Mn-exposed cells from mitochondrial disruption and apoptosis. The histological analysis and Hoechst 33258 staining of brain sections of Mn-injected rats in the striatum showed a decrease in cellular mass paralleled with an increase in the occurrence of apoptotic nuclei. Opa-1 and Drp-1 expression levels were also changed by Mn-treatment. Our results demonstrate for the first time that abnormal mitochondrial dynamics is implicated in both in vitro and in vivo Mn toxicity. In addition we show that the imbalance in fusion/fission equilibrium might be involved in Mn-induced apoptosis

  18. Deregulation of Mitochondria-Shaping Proteins Opa-1 and Drp-1 in Manganese-Induced Apoptosis

    Science.gov (United States)

    Alaimo, Agustina; Gorojod, Roxana M.; Beauquis, Juan; Muñoz, Manuel J.; Saravia, Flavia; Kotler, Mónica L.

    2014-01-01

    Mitochondria are dynamic organelles that undergo fusion and fission processes. These events are regulated by mitochondria-shaping proteins. Changes in the expression and/or localization of these proteins lead to a mitochondrial dynamics impairment and may promote apoptosis. Increasing evidence correlates the mitochondrial dynamics disruption with the occurrence of neurodegenerative diseases. Therefore, we focused on this topic in Manganese (Mn)-induced Parkinsonism, a disorder associated with Mn accumulation preferentially in the basal ganglia where mitochondria from astrocytes represent an early target. Using MitoTracker Red staining we observed increased mitochondrial network fission in Mn-exposed rat astrocytoma C6 cells. Moreover, Mn induced a marked decrease in fusion protein Opa-1 levels as well as a dramatic increase in the expression of fission protein Drp-1. Additionally, Mn provoked a significant release of high MW Opa-1 isoforms from the mitochondria to the cytosol as well as an increased Drp-1 translocation to the mitochondria. Both Mdivi-1, a pharmacological Drp-1 inhibitor, and rat Drp-1 siRNA reduced the number of apoptotic nuclei, preserved the mitochondrial network integrity and prevented cell death. CsA, an MPTP opening inhibitor, prevented mitochondrial Δψm disruption, Opa-1 processing and Drp-1 translocation to the mitochondria therefore protecting Mn-exposed cells from mitochondrial disruption and apoptosis. The histological analysis and Hoechst 33258 staining of brain sections of Mn-injected rats in the striatum showed a decrease in cellular mass paralleled with an increase in the occurrence of apoptotic nuclei. Opa-1 and Drp-1 expression levels were also changed by Mn-treatment. Our results demonstrate for the first time that abnormal mitochondrial dynamics is implicated in both in vitro and in vivo Mn toxicity. In addition we show that the imbalance in fusion/fission equilibrium might be involved in Mn-induced apoptosis. This knowledge may

  19. Assessment of anomalous seepage conditions in the Opa dam ...

    African Journals Online (AJOL)

    Verdant vegetation on the downstream side of the embankment and location of water ponds at the toe of the embankment around the identified seepage zones are field confirmation of the anomalous seepage. KEY WORDS: Anomalous seepage; Assessment; Opa Dam Embankment. Global Journal of Geological Sciences ...

  20. Syndromic parkinsonism and dementia associated with OPA 1 missense mutations

    Science.gov (United States)

    Musumeci, Olimpia; Caporali, Leonardo; Zanna, Claudia; La Morgia, Chiara; Del Dotto, Valentina; Porcelli, Anna Maria; Rugolo, Michela; Valentino, Maria Lucia; Iommarini, Luisa; Maresca, Alessandra; Barboni, Piero; Carbonelli, Michele; Trombetta, Costantino; Valente, Enza Maria; Patergnani, Simone; Giorgi, Carlotta; Pinton, Paolo; Rizzo, Giovanni; Tonon, Caterina; Lodi, Raffaele; Avoni, Patrizia; Liguori, Rocco; Baruzzi, Agostino; Toscano, Antonio; Zeviani, Massimo

    2015-01-01

    Objective Mounting evidence links neurodegenerative disorders such as Parkinson disease and Alzheimer disease with mitochondrial dysfunction, and recent emphasis has focused on mitochondrial dynamics and quality control. Mitochondrial dynamics and mtDNA maintenance is another link recently emerged, implicating mutations in the mitochondrial fusion genes OPA1 and MFN2 in the pathogenesis of multisystem syndromes characterized by neurodegeneration and accumulation of mtDNA multiple deletions in postmitotic tissues. Here, we report 2 Italian families affected by dominant chronic progressive external ophthalmoplegia (CPEO) complicated by parkinsonism and dementia. Methods Patients were extensively studied by optical coherence tomography (OCT) to assess retinal nerve fibers, and underwent muscle and brain magnetic resonance spectroscopy (MRS), and muscle biopsy and fibroblasts were analyzed. Candidate genes were sequenced, and mtDNA was analyzed for rearrangements. Results Affected individuals displayed a slowly progressive syndrome characterized by CPEO, mitochondrial myopathy, sensorineural deafness, peripheral neuropathy, parkinsonism, and/or cognitive impairment, in most cases without visual complains, but with subclinical loss of retinal nerve fibers at OCT. Muscle biopsies showed cytochrome c oxidase‐negative fibers and mtDNA multiple deletions, and MRS displayed defective oxidative metabolism in muscle and brain. We found 2 heterozygous OPA1 missense mutations affecting highly conserved amino acid positions (p.G488R, p.A495V) in the guanosine triphosphatase domain, each segregating with affected individuals. Fibroblast studies showed a reduced amount of OPA1 protein with normal mRNA expression, fragmented mitochondria, impaired bioenergetics, increased autophagy and mitophagy. Interpretation The association of CPEO and parkinsonism/dementia with subclinical optic neuropathy widens the phenotypic spectrum of OPA1 mutations, highlighting the association of

  1. LSGermOPA, a custom OPA of 384 EST-derived SNPs for high-throughput lettuce (Lactuca sativa L.) germplasm fingerprinting

    Science.gov (United States)

    We assessed the genetic diversity and population structure among 148 cultivated lettuce (Lactuca sativa L.) accessions using the high-throughput GoldenGate assay and 384 EST (Expressed Sequence Tag)-derived SNP (single nucleotide polymorphism) markers. A custom OPA (Oligo Pool All), LSGermOPA was fo...

  2. A novel OPA1 mutation in a Chinese family with autosomal dominant optic atrophy

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Juanjuan; Yuan, Yimin; Lin, Bing; Feng, Hao; Li, Yan [School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou 325027, Zhejiang (China); Dai, Xianning; Zhou, Huihui [Attardi Institute of Mitochondrial Biomedicine and Zhejiang Provincial Key Laboratory of Medical Genetics, School of Life Sciences, Wenzhou Medical College, Wenzhou 325035, Zhejiang (China); Dong, Xujie [School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou 325027, Zhejiang (China); Liu, Xiao-Ling, E-mail: lxl@mail.eye.ac.cn [School of Ophthalmology and Optometry, Wenzhou Medical College, Wenzhou 325027, Zhejiang (China); Guan, Min-Xin, E-mail: min-xin.guan@cchmc.org [Attardi Institute of Mitochondrial Biomedicine and Zhejiang Provincial Key Laboratory of Medical Genetics, School of Life Sciences, Wenzhou Medical College, Wenzhou 325035, Zhejiang (China); Institute of Genetics, Zhejiang University, Hangzhou, Zhejiang 310012 (China); Division of Human Genetics, Cincinnati Children' s Hospital Medical Center, OH 45229 (United States)

    2012-03-23

    Highlights: Black-Right-Pointing-Pointer We report the characterization of a four-generation large Chinese family with ADOA. Black-Right-Pointing-Pointer We find a new heterozygous mutation c.C1198G in OPA1 gene which may be a novel pathogenic mutation in this pedigree. Black-Right-Pointing-Pointer We do not find any mitochondrial DNA mutations associated with optic atrophy. Black-Right-Pointing-Pointer Other factors may also contribute to the phenotypic variability of ADOA in this pedigree. -- Abstract: A large four-generation Chinese family with autosomal dominant optic atrophy (ADOA) was investigated in the present study. Eight of the family members were affected in this pedigree. The affected family members exhibited early-onset and progressive visual impairment, resulting in mild to profound loss of visual acuity. The average age-at-onset was 15.9 years. A new heterozygous mutation c.C1198G was identified by sequence analysis of the 12th exon of the OPA1 gene. This mutation resulted in a proline to alanine substitution at codon 400, which was located in an evolutionarily conserved region. This missense mutation in the GTPase domain was supposed to result in a loss of function for the encoded protein and act through a dominant negative effect. No other mutations associated with optic atrophy were found in our present study. The c.C1198G heterozygous mutation in the OPA1 gene may be a novel key pathogenic mutation in this pedigree with ADOA. Furthermore, additional nuclear modifier genes, environmental factors, and psychological factors may also contribute to the phenotypic variability of ADOA in this pedigree.

  3. Molecular Typing of Neisseria gonorrhoeae Isolates by Opa-Typing and Ribotyping in New Delhi, India

    Directory of Open Access Journals (Sweden)

    Pejvak Khaki

    2009-01-01

    Full Text Available Control and preventive measures for gonococcal infections are based on precise epidemiological characteristics of N. gonorrhoeae isolates. In the present study the potential utility of opa-typing and ribotyping for molecular epidemiological study of consecutive gonococcal strains was determined. Sixty gonococcal isolates were subjected to ribotyping with two restriction enzymes, AvaII and HincII, and opa-typing with TaqI and HpaII for epidemiological characterization of gonococcal population. Ribotyping with AvaII yielded 6 ribotype patterns while twelve RFLP patterns were observed with HincII. Opa-typing of the 60 isolates revealed a total 54 opa-types, which 48 were unique and 6 formed clusters. Fifty-two opa-types were observed with TaqI-digested PCR product while opa-typing with HpaII demonstrated 54 opa-types. The opa-types from isolates that were epidemiologically unrelated were distinct, whereas those from the sexual contacts were identical. The results showed that opa-typing is highly useful for characterizing gonococcal strains from sexual contacts and has more discriminatory than ribotyping that could differentiate between gonococci of the same ribotype. The technique even with a single restriction enzyme has a high level of discrimination (99.9% between epidemiologically unrelated isolates. In conclusion, the molecular methods such as opa-typing and ribotyping can be used for epidemiological characterization of gonococcal strains.

  4. Solving a 50 year mystery of a missing OPA1 mutation: more insights from the first family diagnosed with autosomal dominant optic atrophy

    Directory of Open Access Journals (Sweden)

    Zrenner Eberhart

    2010-06-01

    Full Text Available Abstract Background Up to the 1950s, there was an ongoing debate about the diversity of hereditary optic neuropathies, in particular as to whether all inherited optic atrophies can be ascribed to Leber's hereditary optic neuropathy (LHON or represent different disease entities. In 1954 W. Jaeger published a detailed clinical and genealogical investigation of a large family with explicit autosomal dominant segregation of optic atrophy thus proving the existence of a discrete disease different from LHON, which is nowadays known as autosomal dominant optic atrophy (ADOA. Since the year 2000 ADOA is associated with genomic mutations in the OPA1 gene, which codes for a protein that is imported into mitochondria where it is required for mitochondrial fusion. Interestingly enough, the underlying mutation in this family has not been identified since then. Results We have reinvestigated this family with the aim to identify the mutation and to further clarify the underlying pathomechanism. Patients showed a classical non-syndromic ADOA. The long term deterioration in vision in the two teenagers examined 50 years later is of particular note 5/20 to 6/120. Multiplex ligation probe amplification revealed a duplication of the OPA1 exons 7-9 which was confirmed by long distance PCR and cDNA analysis, resulting in an in-frame duplication of 102 amino acids. Segregation was verified in 53 available members of the updated pedigree and a penetrance of 88% was calculated. Fibroblast cultures from skin biopsies were established to assess the mitochondrial network integrity and to qualitatively and quantitatively study the consequences of the mutation on transcript and protein level. Fibroblast cultures demonstrated a fragmented mitochondrial network. Processing of the OPA1 protein was altered. There was no correlation of the OPA1 transcript levels and the OPA1 protein levels in the fibroblasts. Intriguingly an overall decrease of mitochondrial proteins was observed

  5. OPA3, mutated in 3-methylglutaconic aciduria type III, encodes two transcripts targeted primarily to mitochondria

    DEFF Research Database (Denmark)

    Huizing, Marjan; Dorward, Heidi; Ly, Lien

    2010-01-01

    3-Methylglutaconic aciduria type III (3-MGCA type III), caused by recessive mutations in the 2-exon gene OPA3, is characterized by early-onset bilateral optic atrophy, later-onset extrapyramidal dysfunction, and increased urinary excretion of 3-methylglutaconic acid and 3-methylglutaric acid. Her...... in the mitochondrion rather than the peroxisome and implicate loss of OPA3A rather than gain of OPA3B in disease etiology....

  6. Novel OPA1 missense mutation in a family with optic atrophy and severe widespread neurological disorder.

    Science.gov (United States)

    Liskova, Petra; Ulmanova, Olga; Tesina, Petr; Melsova, Hana; Diblik, Pavel; Hansikova, Hana; Tesarova, Marketa; Votruba, Marcela

    2013-05-01

    To identify the underlying molecular genetic cause in a Czech family with optic atrophy, deafness, ptosis, ophthalmoplegia, polyneuropathy and ataxia transmitted as an autosomal dominant trait. Ophthalmological and neurological examination followed by molecular genetic analyses. Seven family members were clinically affected. There was a variable but progressive visual, hearing and neurological disability across the family as a whole. The majority of subjects presented with impairment of visual function and a variable degree of ptosis and/or ophthalmoplegia from the first to the third decade of life. Deafness, neuropathy and ataxia appeared later, in the third and fourth decade. Migraine, tachycardia, intention tremor, nystagmus and cervical dystonia were observed in isolated individuals. A significant overall feature was the high level of neurological disability leading to 3 of 4 members being unable to walk or stand unaided before the age of 60 years. A novel missense mutation c.1345A>C (p.Thr449Pro) in OPA1 segregating with the disease phenotype over three generations was detected. In silico analysis supported pathogenicity of the identified sequence variant. Our work expands the spectrum of mutation in OPA1, which may lead to severe multisystem neurological disorder. The molecular genetic cause of dominant optic atrophy in the Czech population is reported for the first time. We propose that regular cardiac follow-up in patients diagnosed with dominant optic atrophy and widespread neurological disease should be considered. © 2013 The Authors. Acta Ophthalmologica © 2013 Acta Ophthalmologica Scandinavica Foundation.

  7. Genomic deletions in OPA1 in Danish patients with autosomal dominant optic atrophy

    DEFF Research Database (Denmark)

    Almind, Gitte J; Grønskov, Karen; Milea, Dan

    2011-01-01

    Autosomal dominant optic atrophy (ADOA, Kjer disease, MIM #165500) is the most common form of hereditary optic neuropathy. Mutations in OPA1 located at chromosome 3q28 are the predominant cause for ADOA explaining between 32 and 89% of cases. Although deletions of OPA1 were recently reported...... in ADOA, the frequency of OPA1 genomic rearrangements in Denmark, where ADOA has a high prevalence, is unknown. The aim of the study was to identify copy number variations in OPA1 in Danish ADOA patients....

  8. Elektronisen urheilun tapahtuman järjestämisen opas

    OpenAIRE

    Kemppainen, Toni

    2017-01-01

    Tämän opinnäytetyön tavoitteena oli kehittää yleisluontoinen opas elektronisen urheilun tapahtuman ja turnauksen järjestämisestä. Elektroninen urheilu on tullut valtamedian ja kansan tietoisuuteen Suomessa parin viimeisen vuoden aikana. Opinnäytetyön teoriaosuudessa kerrotaan, minkälaisia tapahtumia on olemassa. Yleistietouden lisäksi kerrotaan tapahtumien järjestämisen eri osa-alueista osana järjestämisprojektia. Oppaan alussa käsitellään elektronista urheilua aiheena yleisesti, ja...

  9. Biodiesel Emissions Analysis Program

    Science.gov (United States)

    Using existing data, the EPA's biodiesel emissions analysis program sought to quantify the air pollution emission effects of biodiesel for diesel engines that have not been specifically modified to operate on biodiesel.

  10. Program risk analysis handbook

    Science.gov (United States)

    Batson, R. G.

    1987-01-01

    NASA regulations specify that formal risk analysis be performed on a program at each of several milestones. Program risk analysis is discussed as a systems analysis approach, an iterative process (identification, assessment, management), and a collection of techniques. These techniques, which range from extremely simple to complex network-based simulation, are described in this handbook in order to provide both analyst and manager with a guide for selection of the most appropriate technique. All program risk assessment techniques are shown to be based on elicitation and encoding of subjective probability estimates from the various area experts on a program. Techniques to encode the five most common distribution types are given. Then, a total of twelve distinct approaches to risk assessment are given. Steps involved, good and bad points, time involved, and degree of computer support needed are listed. Why risk analysis should be used by all NASA program managers is discussed. Tools available at NASA-MSFC are identified, along with commercially available software. Bibliography (150 entries) and a program risk analysis check-list are provided.

  11. Probabilistic Structural Analysis Program

    Science.gov (United States)

    Pai, Shantaram S.; Chamis, Christos C.; Murthy, Pappu L. N.; Stefko, George L.; Riha, David S.; Thacker, Ben H.; Nagpal, Vinod K.; Mital, Subodh K.

    2010-01-01

    NASA/NESSUS 6.2c is a general-purpose, probabilistic analysis program that computes probability of failure and probabilistic sensitivity measures of engineered systems. Because NASA/NESSUS uses highly computationally efficient and accurate analysis techniques, probabilistic solutions can be obtained even for extremely large and complex models. Once the probabilistic response is quantified, the results can be used to support risk-informed decisions regarding reliability for safety-critical and one-of-a-kind systems, as well as for maintaining a level of quality while reducing manufacturing costs for larger-quantity products. NASA/NESSUS has been successfully applied to a diverse range of problems in aerospace, gas turbine engines, biomechanics, pipelines, defense, weaponry, and infrastructure. This program combines state-of-the-art probabilistic algorithms with general-purpose structural analysis and lifting methods to compute the probabilistic response and reliability of engineered structures. Uncertainties in load, material properties, geometry, boundary conditions, and initial conditions can be simulated. The structural analysis methods include non-linear finite-element methods, heat-transfer analysis, polymer/ceramic matrix composite analysis, monolithic (conventional metallic) materials life-prediction methodologies, boundary element methods, and user-written subroutines. Several probabilistic algorithms are available such as the advanced mean value method and the adaptive importance sampling method. NASA/NESSUS 6.2c is structured in a modular format with 15 elements.

  12. Chemical exchange program analysis.

    Energy Technology Data Exchange (ETDEWEB)

    Waffelaert, Pascale

    2007-09-01

    As part of its EMS, Sandia performs an annual environmental aspects/impacts analysis. The purpose of this analysis is to identify the environmental aspects associated with Sandia's activities, products, and services and the potential environmental impacts associated with those aspects. Division and environmental programs established objectives and targets based on the environmental aspects associated with their operations. In 2007 the most significant aspect identified was Hazardous Materials (Use and Storage). The objective for Hazardous Materials (Use and Storage) was to improve chemical handling, storage, and on-site movement of hazardous materials. One of the targets supporting this objective was to develop an effective chemical exchange program, making a business case for it in FY07, and fully implementing a comprehensive chemical exchange program in FY08. A Chemical Exchange Program (CEP) team was formed to implement this target. The team consists of representatives from the Chemical Information System (CIS), Pollution Prevention (P2), the HWMF, Procurement and the Environmental Management System (EMS). The CEP Team performed benchmarking and conducted a life-cycle analysis of the current management of chemicals at SNL/NM and compared it to Chemical Exchange alternatives. Those alternatives are as follows: (1) Revive the 'Virtual' Chemical Exchange Program; (2) Re-implement a 'Physical' Chemical Exchange Program using a Chemical Information System; and (3) Transition to a Chemical Management Services System. The analysis and benchmarking study shows that the present management of chemicals at SNL/NM is significantly disjointed and a life-cycle or 'Cradle-to-Grave' approach to chemical management is needed. This approach must consider the purchasing and maintenance costs as well as the cost of ultimate disposal of the chemicals and materials. A chemical exchange is needed as a mechanism to re-apply chemicals on site. This

  13. Molecular screening of 980 cases of suspected hereditary optic neuropathy with a report on 77 novel OPA1 mutations

    DEFF Research Database (Denmark)

    Ferré, Marc; Bonneau, Dominique; Milea, Dan

    2009-01-01

    We report the results of molecular screening in 980 patients carried out as part of their work-up for suspected hereditary optic neuropathies. All the patients were investigated for Leber's hereditary optic neuropathy (LHON) and autosomal dominant optic atrophy (ADOA), by searching for the ten...... primary LHON-causing mtDNA mutations and examining the entire coding sequences of the OPA1 and OPA3 genes, the two genes currently identified in ADOA. Molecular defects were identified in 440 patients (45% of screened patients). Among these, 295 patients (67%) had an OPA1 mutation, 131 patients (30%) had...... an mtDNA mutation, and 14 patients (3%), belonging to three unrelated families, had an OPA3 mutation. Interestingly, OPA1 mutations were found in 157 (40%) of the 392 apparently sporadic cases of optic atrophy. The eOPA1 locus-specific database now contains a total of 204 OPA1 mutations, including 77...

  14. OPA1 deficiency promotes secretion of FGF21 from muscle that prevents obesity and insulin resistance.

    Science.gov (United States)

    Pereira, Renata Oliveira; Tadinada, Satya M; Zasadny, Frederick M; Oliveira, Karen Jesus; Pires, Karla Maria Pereira; Olvera, Angela; Jeffers, Jennifer; Souvenir, Rhonda; Mcglauflin, Rose; Seei, Alec; Funari, Trevor; Sesaki, Hiromi; Potthoff, Matthew J; Adams, Christopher M; Anderson, Ethan J; Abel, E Dale

    2017-07-14

    Mitochondrial dynamics is a conserved process by which mitochondria undergo repeated cycles of fusion and fission, leading to exchange of mitochondrial genetic content, ions, metabolites, and proteins. Here, we examine the role of the mitochondrial fusion protein optic atrophy 1 (OPA1) in differentiated skeletal muscle by reducing OPA1 gene expression in an inducible manner. OPA1 deficiency in young mice results in non-lethal progressive mitochondrial dysfunction and loss of muscle mass. Mutant mice are resistant to age- and diet-induced weight gain and insulin resistance, by mechanisms that involve activation of ER stress and secretion of fibroblast growth factor 21 (FGF21) from skeletal muscle, resulting in increased metabolic rates and improved whole-body insulin sensitivity. OPA1-elicited mitochondrial dysfunction activates an integrated stress response that locally induces muscle atrophy, but via secretion of FGF21 acts distally to modulate whole-body metabolism. © 2017 The Authors.

  15. SNAP - Program for Symbolic Analysis

    Directory of Open Access Journals (Sweden)

    Z. Kolka

    1999-04-01

    Full Text Available The paper deals with a program SNAP for symbolic analysis of linear circuits in frequency domain. The program is suitable for analysis of circuits with ideal network elements to explore basic principles of their operation. Besides graphical presentation the analysis results can be exported to popular mathematical programs for further processing. Currently, an algorithm for exact symbolic analysis is implemented. Therefore the program is suitable for relatively small circuits.

  16. OPA1-related dominant optic atrophy is not strongly influenced by mitochondrial DNA background

    Directory of Open Access Journals (Sweden)

    Amati-Bonneau Patrizia

    2009-07-01

    Full Text Available Abstract Background Leber's hereditary optic neuropathy (LHON and autosomal dominant optic atrophy (ADOA are the most frequent forms of hereditary optic neuropathies. LHON is associated with mitochondrial DNA (mtDNA mutations whereas ADOA is mainly due to mutations in the OPA1 gene that encodes a mitochondrial protein involved in the mitochondrial inner membrane remodeling. A striking influence of mtDNA haplogroup J on LHON expression has been demonstrated and it has been recently suggested that this haplogroup could also influence ADOA expression. In this study, we have tested the influence of mtDNA backgrounds on OPA1 mutations. Methods To define the relationships between OPA1 mutations and mtDNA backgrounds, we determined the haplogroup affiliation of 41 French patients affected by OPA1-related ADOA by control-region sequencing and RFLP survey of their mtDNAs. Results The comparison between patient and reference populations did not revealed any significant difference. Conclusion Our results argue against a strong influence of mtDNA background on ADOA expression. These data allow to conclude that OPA1 could be considered as a "severe mutation", directly responsible of the optic atrophy, whereas OPA1-negative ADOA and LHON mutations need an external factor(s to express the pathology (i.e. synergistic interaction with mitochondrial background.

  17. Nonlinear programming analysis and methods

    CERN Document Server

    Avriel, Mordecai

    2012-01-01

    This text provides an excellent bridge between principal theories and concepts and their practical implementation. Topics include convex programming, duality, generalized convexity, analysis of selected nonlinear programs, techniques for numerical solutions, and unconstrained optimization methods.

  18. GAP Analysis Program (GAP)

    Data.gov (United States)

    Kansas Data Access and Support Center — The Kansas GAP Analysis Land Cover database depicts 43 land cover classes for the state of Kansas. The database was generated using a two-stage hybrid classification...

  19. Pattern of retinal ganglion cell loss in dominant optic atrophy due to OPA1 mutations.

    Science.gov (United States)

    Yu-Wai-Man, P; Bailie, M; Atawan, A; Chinnery, P F; Griffiths, P G

    2011-05-01

    The majority of patients with autosomal dominant optic atrophy (DOA) harbour pathogenic OPA1 mutations. Although DOA is characterised by the preferential loss of retinal ganglion cells (RGCs), about 20% of patients with OPA1 mutations will develop a more severe disease variant (DOA+), with additional neuromuscular features. In this prospective, observational case series, optical coherence tomography (OCT) was used to define the pattern of retinal nerve fibre layer (RNFL) loss in patients with both the pure and syndromal forms of DOA. Forty patients with a molecular diagnosis of DOA due to OPA1 mutations were prospectively recruited from our neuro-ophthalmology clinic: 26 patients with isolated optic atrophy and 14 patients manifesting DOA+ features. Peripapillary RNFL thickness was measured with the Fast RNFL (3.4) acquisition protocol on a Stratus OCT. There was a statistically significant reduction in average RNFL thickness in the OPA1 group compared with normal controls (PDOA+ features had worse visual outcomes compared with patients with pure DOA. Except in the temporal quadrant, RNFL measurements were significantly thinner for the DOA+ group. There was an inverse correlation between average RNFL thickness and logarithm of the minimum angle of resolution (LogMAR) visual acuity (PDOA is characterised by severe involvement of the temporal papillomacular bundle, with relative sparing of the nasal fibres. RNFL thinning is more pronounced in patients with DOA+ phenotypes.

  20. OPA3, mutated in 3-methylglutaconic aciduria type III, encodes two transcripts targeted primarily to mitochondria

    DEFF Research Database (Denmark)

    Huizing, Marjan; Dorward, Heidi; Ly, Lien

    2010-01-01

    3-Methylglutaconic aciduria type III (3-MGCA type III), caused by recessive mutations in the 2-exon gene OPA3, is characterized by early-onset bilateral optic atrophy, later-onset extrapyramidal dysfunction, and increased urinary excretion of 3-methylglutaconic acid and 3-methylglutaric acid. Her...

  1. Medicare Part D Program Analysis

    Data.gov (United States)

    U.S. Department of Health & Human Services — This page contains information on Part D program analysis performed by CMS. These reports will also be used to better identify, evaluate and measure the effects of...

  2. Neuroradiological findings expand the phenotype of OPA1-related mitochondrial dysfunction.

    Science.gov (United States)

    Roubertie, Agathe; Leboucq, Nicolas; Picot, Marie Christine; Nogue, Erika; Brunel, Hervé; Le Bars, Emmanuelle; Manes, Gael; Angebault Prouteau, Claire; Blanchet, Catherine; Mondain, Michel; Chevassus, Hugues; Amati-Bonneau, Patrizia; Sarzi, Emmanuelle; Pagès, Michel; Villain, Max; Meunier, Isabelle; Lenaers, Guy; Hamel, Christian P

    2015-02-15

    OPA1 mutations are responsible for more than half of autosomal dominant optic atrophy (ADOA), a blinding disease affecting the retinal ganglion neurons. In most patients the clinical presentation is restricted to the optic nerve degeneration, albeit in 20% of them, additional neuro-sensorial symptoms might be associated to the loss of vision, as frequently encountered in mitochondrial diseases. This study describes clinical and neuroradiological features of OPA1 patients. Twenty two patients from 17 families with decreased visual acuity related to optic atrophy and carrying an OPA1 mutation were enrolled. Patients underwent neuro-ophthalmological examinations. Brain magnetic resonance imaging (T1, T2 and flair sequences) was performed on a 1.5-Tesla MR Unit. Twenty patients underwent 2-D proton spectroscopic imaging. Brain imaging disclosed abnormalities in 12 patients. Cerebellar atrophy mainly involving the vermis was observed in almost a quarter of the patients; other abnormalities included unspecific white matter hypersignal, hemispheric cortical atrophy, and lactate peak. Neurological examination disclosed one patient with a transient right hand motor deficit and ENT examination revealed hearing impairment in 6 patients. Patients with abnormal MRI were characterized by: (i) an older age (ii) more severe visual impairment with chronic visual acuity deterioration, and (iii) more frequent associated deafness. Our results demonstrate that brain imaging abnormalities are common in OPA1 patients, even in those with normal neurological examination. Lactate peak, cerebellar and cortical atrophies are consistent with the mitochondrial dysfunction related to OPA1 mutations and might result from widespread neuronal degeneration. Copyright © 2015 Elsevier B.V. All rights reserved.

  3. XML Graphs in Program Analysis

    DEFF Research Database (Denmark)

    Møller, Anders; Schwartzbach, Michael I.

    2011-01-01

    XML graphs have shown to be a simple and effective formalism for representing sets of XML documents in program analysis. It has evolved through a six year period with variants tailored for a range of applications. We present a unified definition, outline the key properties including validation...... of XML graphs against different XML schema languages, and provide a software package that enables others to make use of these ideas. We also survey the use of XML graphs for program analysis with four very different languages: XACT (XML in Java), Java Servlets (Web application programming), XSugar...... (transformations between XML and non-XML data), and XSLT (stylesheets for transforming XML documents)....

  4. Novel Applications for Oxalate-Phosphate-Amine Metal-Organic-Frameworks (OPA-MOFs): Can an Iron-Based OPA-MOF Be Used as Slow-Release Fertilizer?

    Science.gov (United States)

    Anstoetz, Manuela; Rose, Terry J; Clark, Malcolm W; Yee, Lachlan H; Raymond, Carolyn A; Vancov, Tony

    2015-01-01

    A porous iron-based oxalate-phosphate-amine metal-organic framework material (OPA-MOF) was investigated as a microbially-induced slow-release nitrogen (N) and phosphorus (P) fertilizer. Seedling growth, grain yields, nutrient uptake of wheat plants, and soil dynamics in incubated soil, were investigated using OPA-MOF vs standard P (triple-superphosphate) and N (urea) fertilizers in an acidic Ferralsol at two application rates (equivalent 120 and 40 kg N ha(-1)). While urea hydrolysis in the OPA-MOF treatment was rapid, conversion of ammonium to nitrate was significantly inhibited compared to urea treatment. Reduced wheat growth in OPA-MOF treatments was not caused by N-deficiency, but by limited P-bioavailability. Two likely reasons were slow P-mobilisation from the OPA-MOF or rapid P-binding in the acid soil. P-uptake and yield in OPA-MOF treatments were significantly higher than in nil-P controls, but significantly lower than in conventionally-fertilised plants. OPA-MOF showed potential as enhanced efficiency N fertilizer. However, as P-bioavailability was insufficient to meet plant demands, further work should determine if P-availability may be enhanced in alkaline soils, or whether central ions other than Fe, forming the inorganic metal-P framework in the MOF, may act as a more effective P-source in acid soils.

  5. Novel Applications for Oxalate-Phosphate-Amine Metal-Organic-Frameworks (OPA-MOFs): Can an Iron-Based OPA-MOF Be Used as Slow-Release Fertilizer?

    Science.gov (United States)

    Anstoetz, Manuela; Rose, Terry J.; Clark, Malcolm W.; Yee, Lachlan H.; Raymond, Carolyn A.; Vancov, Tony

    2015-01-01

    A porous iron-based oxalate-phosphate-amine metal-organic framework material (OPA-MOF) was investigated as a microbially-induced slow-release nitrogen (N) and phosphorus (P) fertilizer. Seedling growth, grain yields, nutrient uptake of wheat plants, and soil dynamics in incubated soil, were investigated using OPA-MOF vs standard P (triple-superphosphate) and N (urea) fertilizers in an acidic Ferralsol at two application rates (equivalent 120 and 40 kg N ha-1). While urea hydrolysis in the OPA-MOF treatment was rapid, conversion of ammonium to nitrate was significantly inhibited compared to urea treatment. Reduced wheat growth in OPA-MOF treatments was not caused by N-deficiency, but by limited P-bioavailability. Two likely reasons were slow P-mobilisation from the OPA-MOF or rapid P-binding in the acid soil. P-uptake and yield in OPA-MOF treatments were significantly higher than in nil-P controls, but significantly lower than in conventionally-fertilised plants. OPA-MOF showed potential as enhanced efficiency N fertilizer. However, as P-bioavailability was insufficient to meet plant demands, further work should determine if P-availability may be enhanced in alkaline soils, or whether central ions other than Fe, forming the inorganic metal-P framework in the MOF, may act as a more effective P-source in acid soils. PMID:26633174

  6. Distributed abnormalities of brain white matter architecture in patients with dominant optic atrophy and OPA1 mutations.

    Science.gov (United States)

    Rocca, Maria A; Bianchi-Marzoli, Stefania; Messina, Roberta; Cascavilla, Maria Lucia; Zeviani, Massimo; Lamperti, Costanza; Milesi, Jacopo; Carta, Arturo; Cammarata, Gabriella; Leocani, Letizia; Lamantea, Eleonora; Bandello, Francesco; Comi, Giancarlo; Falini, Andrea; Filippi, Massimo

    2015-05-01

    Using advanced MRI techniques, we investigated the presence and topographical distribution of brain grey matter (GM) and white matter (WM) alterations in dominant optic atrophy (DOA) patients with genetically proven OPA1 mutation as well as their correlation with clinical and neuro-ophthalmologic findings. Nineteen DOA patients underwent neurological, neuro-ophthalmologic and brainstem auditory evoked potentials (BAEP) evaluations. Voxel-wise methods were applied to assess regional GM and WM abnormalities in patients compared to 20 healthy controls. Visual acuity was reduced in 16 patients. Six DOA patients (4 with missense mutations) had an abnormal I peripheral component (auditory nerve) at BAEP. Compared to controls, DOA patients had significant atrophy of the optic nerves (p < 0.0001). Voxel-based morphometry (VBM) analysis showed that, compared to controls, DOA patients had significant WM atrophy of the chiasm and optic tracts; whereas no areas of GM atrophy were found. Tract-based spatial statistics (TBSS) analysis showed that compared to controls, DOA patients had significantly lower mean diffusivity, axial and radial diffusivity in the WM of the cerebellum, brainstem, thalamus, fronto-occipital-temporal lobes, including the cingulum, corpus callosum, corticospinal tract and optic radiation bilaterally. No abnormalities of fractional anisotropy were detected. No correlations were found between volumetric and diffusivity abnormalities quantified with MRI and clinical and neuro-ophthalmologic measures of disease severity. Consistently with pathological studies, tissue loss in DOA patients is limited to anterior optic pathways reflecting retinal ganglion cell degeneration. Distributed abnormalities of diffusivity indexes might reflect abnormal intracellular mitochondrial morphology as well as alteration of protein levels due to OPA1 mutations.

  7. Evaluation of Biogenic Amines in Organic and Non-Organic Wines by HPLC OPA Derivatization

    Directory of Open Access Journals (Sweden)

    Ali Üren

    2007-01-01

    Full Text Available Organic and non-organic wines, selected on the basis of consumers’ preference towards healthy products, were produced from the grapes of Vitis vinifera varieties Semillon, Colombard, Cabernet Sauvignon, Merlot and Carignan and possible effects of different wine making techniques were considered. Concentrations of histamine, tyramine, putrescine, cadaverine, ethylamine, methylamine, tryptamine, agmatine and β-phenylethylamine were quantified by HPLC fluorescence detection of o-phthaldialdehyde (OPA derivatives. The order of analyzed parameters in all wines from the highest to the lowest quantities was determined as follows: putrescine > histamine > ethylamine > methylamine > agmatine > tyramine > cadaverine > tryptamine. One of the analyzed compounds (β-phenylethylamine was not detected. The highest average values for organic and non-organic wines were found as follows (in mg/L: putrescine 5.55, ethylamine 0.825 and histamine 0.628 in organic wines, and putrescine 3.68, histamine 1.14 and agmatine 0.662 in non-organic wines. Considering the wine type (organic/non-organic, an important difference was determined for putrescine. Putrescine content in organic wines was significantly greater than in non-organic ones (p=0.008. Evaluating colour of wines (white/red, a statistically significant difference was obtained for methylamine (p=0.028. Taking into account only grape varieties, statistically significant differences were found for histamine, methylamine, tyramine and cadaverine (p<0.05. The results of principal component analysis demonstrated close relations between the following biogenic amines and wines: agmatine and non-organic Colombard; tryptamine or cadaverine and both organic and non-organic Cabernet Sauvignon wines.

  8. Program Analysis as Model Checking

    DEFF Research Database (Denmark)

    Olesen, Mads Chr.

    Software programs are proliferating throughout modern life, to a point where even the simplest appliances such as lightbulbs contain software, in addition to the software embedded in cars and airplanes. The correct functioning of these programs is therefore of the utmost importance, for the quality...... and sustenance of life. Due to the complexity inherent in the software it can be very difficult for the software developer to guarantee the absence of errors; automated support in the form of automated program analysis is therefore essential. Two methods have traditionally been proposed: model checking...... and abstract interpretation. Model checking views the program as a finite automaton and tries to prove logical properties over the automaton model, or present a counter-example if not possible — with a focus on precision. Abstract interpretation translates the program semantics into abstract semantics...

  9. The LTS timing analysis program :

    Energy Technology Data Exchange (ETDEWEB)

    Armstrong, Darrell Jewell; Schwarz, Jens

    2013-08-01

    The LTS Timing Analysis program described in this report uses signals from the Tempest Lasers, Pulse Forming Lines, and Laser Spark Detectors to carry out calculations to quantify and monitor the performance of the the Z-Accelerators laser triggered SF6 switches. The program analyzes Z-shots beginning with Z2457, when Laser Spark Detector data became available for all lines.

  10. Matlab programming for numerical analysis

    CERN Document Server

    Lopez, Cesar

    2014-01-01

    MATLAB is a high-level language and environment for numerical computation, visualization, and programming. Using MATLAB, you can analyze data, develop algorithms, and create models and applications. The language, tools, and built-in math functions enable you to explore multiple approaches and reach a solution faster than with spreadsheets or traditional programming languages, such as C/C++ or Java. Programming MATLAB for Numerical Analysis introduces you to the MATLAB language with practical hands-on instructions and results, allowing you to quickly achieve your goals. You will first become

  11. R data analysis without programming

    CERN Document Server

    Gerbing, David W

    2013-01-01

    This book prepares readers to analyze data and interpret statistical results using R more quickly than other texts. R is a challenging program to learn because code must be created to get started. To alleviate that challenge, Professor Gerbing developed lessR. LessR extensions remove the need to program. By introducing R through less R, readers learn how to organize data for analysis, read the data into R, and produce output without performing numerous functions and programming exercises first. With lessR, readers can select the necessary procedure and change the relevant variables without pro

  12. Puijon hyppyrimäkien käyttöopas

    OpenAIRE

    Petjala, Mika

    2010-01-01

    Tämän opinnäytetyön tavoitteena oli tehdä opas, jota voi käyttää Kuopion kaupungin omistamien Puijon hyppyrimäkien ylläpidossa. Aihe valittiin, koska hyppyrimäkien ylläpidosta oleva tieto on hajallaan eri henkilöillä. Puijon mäkiä käytettäessä on huomattu, että opas, johon on koottu mäkien ylläpidosta olevat perustiedot, olisi tarpeellinen. Työ tulee olemaan Puijon hiihtoseuran koulutusaineistona sekä Puijon hyppyrimäillä kaikkien aiheesta kiinnostuneiden käytettäv...

  13. Judgment of pure fermented soy sauce by fluorescence resonance energy transfer of OPA-tryptophan adduct.

    Science.gov (United States)

    Gao, You-Syuan; Hsieh, Bo-Chuan; Cheng, Tzong-Jih; Chen, Richie L C

    2015-07-01

    Tryptophan was detected with a flow-injection manifold after reacting with mM order of fluorogenic o-phthalaldehyde (OPA)/thiol reagent (pH 10.0) in the carrier stream (0.63 mL/min). Based on the intra-molecular fluorescence resonance energy transfer of OPA-tryptophan adduct, the difference in fluorescence intensity obtained at 280 and 300 nm excitation was used to detect tryptophan content with satisfactory precision (CVtryptophan will decompose during manufacturing non-fermented soy sauce by acid-hydrolysis procedure, the method was used to discriminate pure fermented soy sauces, adulterated soy sauces and chemical soy sauces in less than 5 min. The ratio of tryptophan to total amino acid content served as the index for the judgment, and the results were validated by capillary electrophoresis. Copyright © 2015 Elsevier Ltd. All rights reserved.

  14. Exercise Pretreatment Promotes Mitochondrial Dynamic Protein OPA1 Expression after Cerebral Ischemia in Rats

    Directory of Open Access Journals (Sweden)

    Li Zhang

    2014-03-01

    Full Text Available Exercise training is a neuroprotective strategy in cerebral ischemic injury, but the underlying mechanisms are not yet clear. In the present study, we investigated the effects of treadmill exercise pretreatment on the expression of mitochondrial dynamic proteins. We examined the expression of OPA1/DLP1/MFF/Mfn1/Mfn2, which regulatesmitochondrial fusion and fission, and cytochrome C oxidase subunits (COX subunits, which regulatemitochondrial functions, after middle cerebral artery occlusion (MCAO in rats. T2-weighted magnetic resonance imaging (MRI was evaluated as indices of brain edema after ischemia as well. Treadmill training pretreatment increased the expression levels of OPA1 and COXII/III/IV and alleviated brain edema, indicating that exercise pretreatment provided neuroprotection in cerebral ischemic injury via the regulation of mitochondrial dynamics and functions.

  15. Aloittelevan start-up yrittäjän opas rahoitukseen

    OpenAIRE

    Lamminsalo, Matti

    2015-01-01

    Opinnäytetyö käsittelee start-up rahoitusta ja siihen liittyviä toimintamalleja. Opinnäytetyön tuloksena on syntynyt opaskirja: Aloittelevan start-up yrittäjän opas rahoitukseen. Research about start-up ecosystem with investment aspect. As a result guidebook for start-up investment and how to raise a fund was writen.

  16. A-DROP: A predictive model for the formation of oil particle aggregates (OPAs)

    Science.gov (United States)

    Zhao, Lin; Boufadel, Michel C.; Geng, Xiaolong; Lee, Kenneth; King, Thomas; Robinson, Brian; Fitzpatrick, Faith A.

    2016-01-01

    Oil–particle interactions play a major role in removal of free oil from the water column. We present a new conceptual–numerical model, A-DROP, to predict oil amount trapped in oil–particle aggregates. A new conceptual formulation of oil–particle coagulation efficiency is introduced to account for the effects of oil stabilization by particles, particle hydrophobicity, and oil–particle size ratio on OPA formation. A-DROP was able to closely reproduce the oil trapping efficiency reported in experimental studies. The model was then used to simulate the OPA formation in a typical nearshore environment. Modeling results indicate that the increase of particle concentration in the swash zone would speed up the oil–particle interaction process; but the oil amount trapped in OPAs did not correspond to the increase of particle concentration. The developed A-DROP model could become an important tool in understanding the natural removal of oil and developing oil spill countermeasures by means of oil–particle aggregation.

  17. Program Instrumentation and Trace Analysis

    Science.gov (United States)

    Havelund, Klaus; Goldberg, Allen; Filman, Robert; Rosu, Grigore; Koga, Dennis (Technical Monitor)

    2002-01-01

    Several attempts have been made recently to apply techniques such as model checking and theorem proving to the analysis of programs. This shall be seen as a current trend to analyze real software systems instead of just their designs. This includes our own effort to develop a model checker for Java, the Java PathFinder 1, one of the very first of its kind in 1998. However, model checking cannot handle very large programs without some kind of abstraction of the program. This paper describes a complementary scalable technique to handle such large programs. Our interest is turned on the observation part of the equation: How much information can be extracted about a program from observing a single execution trace? It is our intention to develop a technology that can be applied automatically and to large full-size applications, with minimal modification to the code. We present a tool, Java PathExplorer (JPaX), for exploring execution traces of Java programs. The tool prioritizes scalability for completeness, and is directed towards detecting errors in programs, not to prove correctness. One core element in JPaX is an instrumentation package that allows to instrument Java byte code files to log various events when executed. The instrumentation is driven by a user provided script that specifies what information to log. Examples of instructions that such a script can contain are: 'report name and arguments of all called methods defined in class C, together with a timestamp'; 'report all updates to all variables'; and 'report all acquisitions and releases of locks'. In more complex instructions one can specify that certain expressions should be evaluated and even that certain code should be executed under various conditions. The instrumentation package can hence be seen as implementing Aspect Oriented Programming for Java in the sense that one can add functionality to a Java program without explicitly changing the code of the original program, but one rather writes an

  18. A misleading false-negative result using Neisseria gonorrhoeae opa MGB multiplex PCR assay in patient's rectal sample due to partial mutations of the opa gene.

    Science.gov (United States)

    Vahidnia, Ali; van Empel, Pieter Jan; Costa, Sandra; Oud, Rob T N; van der Straaten, Tahar; Bliekendaal, Harry; Spaargaren, Joke

    2015-07-01

    A 53-year-old homosexual man presented at his general practitioner (GP) practice with a suspicion of sexually transmitted infection. Initial NAAT screening was performed for Chlamydia trachomatis and Neisseria gonorrhoeae. The patient was positive for Neisseria gonorrhoeae both for his urine and rectal sample. The subsequent confirmation test for Neisseria gonorrhoeae by a second laboratory was only confirmed for the urine sample and the rectal sample was negative. We report a case of a potential false-negative diagnosis of Neisseria gonorrhoeae due to mutations of DNA sequence in the probe region of opa-MGB assay of the rectal sample. The patient did not suffer any discomfort as diagnosis of Neisseria gonorrhoeae in his urine sample had already led to treatment by prescribing the patient with Ceftriaxone 500 mg IV dissolved in 1 ml lidocaine 2% and 4 mL saline. The patient also received a prescription for Azithromycin (2x500 mg).

  19. Genetic refinement of dominant optic atrophy (OPA1) locus to within a 2 cM interval of chromosome 3q.

    Science.gov (United States)

    Votruba, M; Moore, A T; Bhattacharya, S S

    1997-01-01

    Autosomal dominant optic atrophy (OPA, MIM 165500) is an eye disease characterised by variable optic atrophy and reduction in visual acuity. It has an insidious onset in the first decade of life and is clinically highly heterogeneous. It is associated with a centrocecal scotoma of varying size and density and an acquired blue-yellow dyschromatopsia. Recent studies of three large Danish pedigrees have mapped a gene for dominant optic atrophy (OPA1) to a 10 cM region on chromosome 3q, between markers D3S1314 and D3S1265 (3q28-qter). Genetic linkage analysis in five British pedigrees confirms mapping to chromosome 3q28-qter. Haplotype analysis of a seven generation pedigree positions the disease causing gene between loci D3S3590 and D3S1305, corresponding to a genetic distance of 2 cM. This represents a significant linkage refinement and should facilitate positional cloning of the disease gene. PMID:9039986

  20. Planetary Protection Bioburden Analysis Program

    Science.gov (United States)

    Beaudet, Robert A.

    2013-01-01

    This program is a Microsoft Access program that performed statistical analysis of the colony counts from assays performed on the Mars Science Laboratory (MSL) spacecraft to determine the bioburden density, 3-sigma biodensity, and the total bioburdens required for the MSL prelaunch reports. It also contains numerous tools that report the data in various ways to simplify the reports required. The program performs all the calculations directly in the MS Access program. Prior to this development, the data was exported to large Excel files that had to be cut and pasted to provide the desired results. The program contains a main menu and a number of submenus. Analyses can be performed by using either all the assays, or only the accountable assays that will be used in the final analysis. There are three options on the first menu: either calculate using (1) the old MER (Mars Exploration Rover) statistics, (2) the MSL statistics for all the assays, or This software implements penetration limit equations for common micrometeoroid and orbital debris (MMOD) shield configurations, windows, and thermal protection systems. Allowable MMOD risk is formulated in terms of the probability of penetration (PNP) of the spacecraft pressure hull. For calculating the risk, spacecraft geometry models, mission profiles, debris environment models, and penetration limit equations for installed shielding configurations are required. Risk assessment software such as NASA's BUMPERII is used to calculate mission PNP; however, they are unsuitable for use in shield design and preliminary analysis studies. The software defines a single equation for the design and performance evaluation of common MMOD shielding configurations, windows, and thermal protection systems, along with a description of their validity range and guidelines for their application. Recommendations are based on preliminary reviews of fundamental assumptions, and accuracy in predicting experimental impact test results. The software

  1. Conducting a SWOT Analysis for Program Improvement

    Science.gov (United States)

    Orr, Betsy

    2013-01-01

    A SWOT (strengths, weaknesses, opportunities, and threats) analysis of a teacher education program, or any program, can be the driving force for implementing change. A SWOT analysis is used to assist faculty in initiating meaningful change in a program and to use the data for program improvement. This tool is useful in any undergraduate or degree…

  2. XML Graphs in Program Analysis

    DEFF Research Database (Denmark)

    Møller, Anders; Schwartzbach, Michael Ignatieff

    2007-01-01

    XML graphs have shown to be a simple and effective formalism for representing sets of XML documents in program analysis. It has evolved through a six year period with variants tailored for a range of applications. We present a unified definition, outline the key properties including validation...... of XML graphs against different XML schema languages, and provide a software package that enables others to make use of these ideas. We also survey four very different applications: XML in Java, Java Servlets and JSP, transformations between XML and non-XML data, and XSLT....

  3. Imetys vauvaperhetyössä : opas sosiaalialalla toimiville vauvaperhetyöntekijöille

    OpenAIRE

    Nupponen, Anna

    2016-01-01

    Tämän opinnäytetyön tarkoituksena on ollut kirjoittaa opas imetyksestä sosiaalialalla toimiville vauvaperhetyöntekijöille. Sosiaalialalla imetys ei yleensä kuulu koulutukseen, vaikka vauvaperheiden kanssa työskentelevät saattavat tavata imettäviä äitejä usean kerran viikossa. Tässä kehittämishankkeessa kysyttiin lyhyen kyselylomakkeen avulla Helsingin kaupungin lastensuojelun perhekuntoutuksen Rastilan Vuorovaikutustiimin työntekijöiltä sekä Helsingin ensikodin työntekijöiltä heidän toive...

  4. TIETOTEKNIIKKA OSALLISUUDEN VAHVISTAJANA : NETINKÄYTTÖOPAS SEURAKUNNAN VAPAAEHTOISTYÖN TYÖKALUKSI

    OpenAIRE

    Natunen, Tarja; Riutta, Roni

    2013-01-01

    TIIVISTELMÄ Natunen Tarja & Riutta Roni. ”Tietotekniikka osallisuuden vahvistajana, netinkäyttöopas seurakunnan vapaaehtoistyön työkaluksi”. Pieksämäki, syksy 2013. 61s. 6 liitettä. Diakonia-ammattikorkeakoulu, Diak Pieksämäki, Sosiaalialan muuntokoulutus, Diakonisen sosiaalityön suuntautumisvaihtoehto, sosionomi (AMK) + diakonin virka-kelpoisuus. Opinnäytetyön päätavoitteena oli luoda Varkauden evankelis-luterilaiselle seurakunnalle vapaaehtoistyöhön uusi työkalu, mikä lisää o...

  5. Unen merkitys nuoren terveyteen ja oppimiseen : Opas Seinäjoen yhteiskoulun 7 - 9- luokkalaisille

    OpenAIRE

    Pajamäki, Tarja; Uutela, Mervi

    2014-01-01

    Tämän opinnäytetyön tarkoituksena oli tuottaa opas Seinäjoen yhteiskoulun 7 - 9- luokkalaisille nuorille unen vaikutuksista heidän terveyteensä ja oppimiseensa. Tavoitteena oli antaa nuorille ajankohtaista tietoa unen merkityksestä heidän terveyteensä ja oppimiseensa. Tavoitteena oli myös kertoa elämäntapojen ja elämäntilanteen vaikutuksista uneen. Sairaanhoitajien, terveydenhoitajien ja muiden nuorten kanssa tekemisissä olevien on hyvä tietää erilaisten psyykkisten sairauksien vaikutuksista ...

  6. Opa-typing can identify epidemiologically distinct subgroups within Neisseria gonorrhoeae multi-antigen sequence type (NG-MAST) clusters

    Science.gov (United States)

    MORRIS, A. K.; PALMER, H. M.; YOUNG, H.

    2008-01-01

    SUMMARY A collection of 106 Neisseria gonorrhoeae ciprofloxacin-resistant isolates were typed using Neisseria gonorrhoeae multi-antigen sequence typing (NG-MAST). Opa-typing was performed on 74 isolates which had non-unique sequence types to determine if further discrimination could be achieved and if so whether this had any epidemiological basis. The 74 isolates were separated into 12 sequence types and 20 opa-types (OT). Seven opa-type clusters were congruent with the sequence types and five sequence types could be subdivided by opa-typing. These results demonstrate that opa-typing can add a further level of discrimination compared with NG-MAST. The surveillance data for isolates in the largest sequence type cluster (ST 147) indicated that two major subdivisions OT 1 and OT 2 differed epidemiologically by patients' sexual preference and geographical location. ST 147 is a common strain that has been isolated in several countries since 1999; our results suggest that it has diverged into at least two epidemiologically discrete forms. PMID:18241521

  7. Drosophila Erect wing (Ewg) controls mitochondrial fusion during muscle growth and maintenance by regulation of the Opa1-like gene.

    Science.gov (United States)

    Rai, Mamta; Katti, Prasanna; Nongthomba, Upendra

    2014-01-01

    Mitochondrial biogenesis and morphological changes are associated with tissue-specific functional demand, but the factors and pathways that regulate these processes have not been completely identified. A lack of mitochondrial fusion has been implicated in various developmental and pathological defects. The spatiotemporal regulation of mitochondrial fusion in a tissue such as muscle is not well understood. Here, we show in Drosophila indirect flight muscles (IFMs) that the nuclear-encoded mitochondrial inner membrane fusion gene, Opa1-like, is regulated in a spatiotemporal fashion by the transcription factor/co-activator Erect wing (Ewg). In IFMs null for Ewg, mitochondria undergo mitophagy and/or autophagy accompanied by reduced mitochondrial functioning and muscle degeneration. By following the dynamics of mitochondrial growth and shape in IFMs, we found that mitochondria grow extensively and fuse during late pupal development to form the large tubular mitochondria. Our evidence shows that Ewg expression during early IFM development is sufficient to upregulate Opa1-like, which itself is a requisite for both late pupal mitochondrial fusion and muscle maintenance. Concomitantly, by knocking down Opa1-like during early muscle development, we show that it is important for mitochondrial fusion, muscle differentiation and muscle organization. However, knocking down Opa1-like, after the expression window of Ewg did not cause mitochondrial or muscle defects. This study identifies a mechanism by which mitochondrial fusion is regulated spatiotemporally by Ewg through Opa1-like during IFM differentiation and growth.

  8. Personal Computer Transport Analysis Program

    Science.gov (United States)

    DiStefano, Frank, III; Wobick, Craig; Chapman, Kirt; McCloud, Peter

    2012-01-01

    The Personal Computer Transport Analysis Program (PCTAP) is C++ software used for analysis of thermal fluid systems. The program predicts thermal fluid system and component transients. The output consists of temperatures, flow rates, pressures, delta pressures, tank quantities, and gas quantities in the air, along with air scrubbing component performance. PCTAP s solution process assumes that the tubes in the system are well insulated so that only the heat transfer between fluid and tube wall and between adjacent tubes is modeled. The system described in the model file is broken down into its individual components; i.e., tubes, cold plates, heat exchangers, etc. A solution vector is built from the components and a flow is then simulated with fluid being transferred from one component to the next. The solution vector of components in the model file is built at the initiation of the run. This solution vector is simply a list of components in the order of their inlet dependency on other components. The component parameters are updated in the order in which they appear in the list at every time step. Once the solution vectors have been determined, PCTAP cycles through the components in the solution vector, executing their outlet function for each time-step increment.

  9. SDOCT Thickness Measurements of Various Retinal Layers in Patients with Autosomal Dominant Optic Atrophy due to OPA1 Mutations

    Directory of Open Access Journals (Sweden)

    Andrea M. Schild

    2013-01-01

    Full Text Available Purpose. To specify thickness values of various retinal layers on macular spectral domain Optical Coherence Tomography (SDOCT scans in patients with autosomal dominant optic atrophy (ADOA compared to healthy controls. Methods. SDOCT volume scans of 7 patients with ADOA (OPA-1 mutation and 14 healthy controls were quantitatively analyzed using manual grading software. Mean thickness values for the ETDRS grid subfields 5–8 were calculated for the spaces neurosensory retina, retinal nerve fiber layer (RNFL, ganglion cell layer (GCL, a combined space of inner plexiform layer/outer plexiform layer/inner nuclear layer (IPL+INL+OPL, and a combined space of outer nuclear layer/photoreceptor layers (ONL+PL. Results. ADOA patients showed statistically significant lower retinal thickness values than controls (. RNFL ( and GCL thicknesses ( were significantly lower in ADOA patients. There was no difference in IPL+INL+OPL and in ONL+PL thickness. Conclusion. Manual subanalysis of macular SDOCT volume scans allowed detailed subanalysis of various retinal layers. Not only RNFL but also GCL thicknesses are reduced in the macular area of ADOA patients whereas subjacent layers are not involved. Together with clinical findings, macular SDOCT helps to identify patients with suspicion for hereditary optic neuropathy before genetic analysis confirms the diagnosis.

  10. ROOT CAUSE ANALYSIS PROGRAM MANUAL

    Energy Technology Data Exchange (ETDEWEB)

    Gravois, Melanie C.

    2007-05-02

    Root Cause Analysis (RCA) identifies the cause of an adverse condition that, if corrected, will preclude recurrence or greatly reduce the probability of recurrence of the same or similar adverse conditions and thereby protect the health and safety of the public, the workers, and the environment. This procedure sets forth the requirements for management determination and the selection of RCA methods and implementation of RCAs that are a result of significant findings from Price-Anderson Amendments Act (PAAA) violations, occurrences/events, Significant Adverse Conditions, and external oversight Corrective Action Requests (CARs) generated by the Office of Enforcement (PAAA headquarters), the U.S. Environmental Protection Agency, and other oversight entities against Lawrence Berkeley National Laboratory (LBNL). Performance of an RCA may result in the identification of issues that should be reported in accordance with the Issues Management Program Manual.

  11. Targeted Metabolomics Reveals Early Dominant Optic Atrophy Signature in Optic Nerves of Opa1delTTAG/+ Mice.

    Science.gov (United States)

    Chao de la Barca, Juan Manuel; Simard, Gilles; Sarzi, Emmanuelle; Chaumette, Tanguy; Rousseau, Guillaume; Chupin, Stéphanie; Gadras, Cédric; Tessier, Lydie; Ferré, Marc; Chevrollier, Arnaud; Desquiret-Dumas, Valérie; Gueguen, Naïg; Leruez, Stéphanie; Verny, Christophe; Miléa, Dan; Bonneau, Dominique; Amati-Bonneau, Patrizia; Procaccio, Vincent; Hamel, Christian; Lenaers, Guy; Reynier, Pascal; Prunier-Mirebeau, Delphine

    2017-02-01

    Dominant optic atrophy (MIM No. 165500) is a blinding condition related to mutations in OPA1, a gene encoding a large GTPase involved in mitochondrial inner membrane dynamics. Although several mouse models mimicking the disease have been developed, the pathophysiological mechanisms responsible for retinal ganglion cell degeneration remain poorly understood. Using a targeted metabolomic approach, we measured the concentrations of 188 metabolites in nine tissues, that is, brain, three types of skeletal muscle, heart, liver, retina, optic nerve, and plasma in symptomatic 11-month-old Opa1delTTAG/+ mice. Significant metabolic signatures were found only in the optic nerve and plasma of female mice. The optic nerve signature was characterized by altered concentrations of phospholipids, amino acids, acylcarnitines, and carnosine, whereas the plasma signature showed decreased concentrations of amino acids and sarcosine associated with increased concentrations of several phospholipids. In contrast, the investigation of 3-month-old presymptomatic Opa1delTTAG/+ mice showed no specific plasma signature but revealed a significant optic nerve signature in both sexes, although with a sex effect. The Opa1delTTAG/+ versus wild-type optic nerve signature was characterized by the decreased concentrations of 10 sphingomyelins and 10 lysophosphatidylcholines, suggestive of myelin sheath alteration, and by alteration in the concentrations of metabolites involved in neuroprotection, such as dimethylarginine, carnitine, spermine, spermidine, carnosine, and glutamate, suggesting a concomitant axonal metabolic dysfunction. Our comprehensive metabolomic investigations revealed in symptomatic as well as in presymptomatic Opa1delTTAG/+ mice, a specific sensitiveness of the optic nerve to Opa1 insufficiency, opening new routes for protective therapeutic strategies.

  12. Roles of Variables and Program Analysis

    OpenAIRE

    Bishop, Craig; Johnson, Colin G.

    2005-01-01

    The idea of roles of variables is to provide a vocabulary for describing the way in which variables are used by experienced programmers. This paper presents work on a system that is designed to automatically check students' role assignments in simple procedural programming. This is achieved by applying program analysis techniques, in particular program slicing and data flow analysis, to programs that students have written and annotated with role assignments.

  13. Reproductive strategy of Oreochromis niloticus (Pisces: Cichlidae in Opa reservoir, Ile-Ife, Nigeria

    Directory of Open Access Journals (Sweden)

    O.O Komolafe

    2007-06-01

    Full Text Available The fish family Cichlidae has a large diversity and dominates African freshwater bodies, with over 200 species reported in inland waters. Sampling for the fish Oreochromis niloticus (Linnaeus in Opa reservoir, Nigeria, started in October 1997 and extended until February 2000. The fishing methods employed for collecting the 1 430 specimens were cast netting and gillnetting. Egg diameter varied between 2.12 mm and 2.69 mm with a mean of 2.47±0.02. Female gonadosomatic index was 1.34±0.01 (0.12-4.06, n= 637. The male gonadosomatic index was 0.39±0.02 (0.03-1.67, n= 789. In Opa reservoir, O. niloticus bred throughout the study period. The species was a maternal mouth brooder with the female fish carrying eggs and fry in the buccal cavities. The sex ratio of O. niloticus was approximately 1:1 in the reservoir. The fecundity of the species was between 73 eggs and 1 810 eggs per female with a mean fecundity of 815 eggs. Rev. Biol. Trop. 55 (2: 595-602. Epub 2007 June, 29.Estudiamos la tilapia, Oreochromis niloticus (Linnaeus en la reserva de Opa, Nigeria, desde octubre 1997 hasta febrero del 2000. Recolectamos 1 430 especímenes con red lanzada y red de arrastre. El diámetro de los huevos varía entre los 2.12 mm y 2.69 mm con un promedio de 2.47±0.02. El índice gonadosomático de las hembras fue de 1.34±0.01 (0.12-4.06, n= 637, y en machos fue de 0.39±0.02 (0.03-1.67, n= 789. En la reserva este pez se reprodujo durante todo el periodo de estudio. Hay cuido materno: la hembra lleva los huevos y alevines en la boca. La proporción machos/hembras fue aproximadamente 1:1. La fecundidad varía entre 73 y 1 810 huevos por hembra con un promedio de 815 huevos.

  14. Utility green pricing programs: A statistical analysis of program effectiveness

    Energy Technology Data Exchange (ETDEWEB)

    Wiser, Ryan; Olson, Scott; Bird, Lori; Swezey, Blair

    2004-02-01

    Development of renewable energy. Such programs have grown in number in recent years. The design features and effectiveness of these programs varies considerably, however, leading a variety of stakeholders to suggest specific marketing and program design features that might improve customer response and renewable energy sales. This report analyzes actual utility green pricing program data to provide further insight into which program features might help maximize both customer participation in green pricing programs and the amount of renewable energy purchased by customers in those programs. Statistical analysis is performed on both the residential and non-residential customer segments. Data comes from information gathered through a questionnaire completed for 66 utility green pricing programs in early 2003. The questionnaire specifically gathered data on residential and non-residential participation, amount of renewable energy sold, program length, the type of renewable supply used, program price/cost premiums, types of consumer research and program evaluation performed, different sign-up options available, program marketing efforts, and ancillary benefits offered to participants.

  15. A randomised single-blind comparison of the effectiveness of Tristel Fuse (chlorine dioxide) as an office-based fluid soak, with Cidex OPA (ortho-phthaldehyde) using an automated endoscopic reprocessor (AER) as high-level disinfection for flexible cystoscopes.

    Science.gov (United States)

    Gilling, Peter J; Reuther, Rana M; Addidle, Michael; Lockhart, Michelle M; Frampton, Christopher M; Fraundorfer, Mark R

    2013-11-01

    To compare the effectiveness, safety and cost of Tristel Fuse (chlorine dioxide) with Cidex OPA (ortho-phthaldehyde; 1,2-benzenedicarboxaldehyde) in an automated endoscopic reprocessor (AER) for high-level disinfection of flexible cystoscopes. A randomised single-blind study comparing the high-level disinfectants Tristel Fuse as a simple office-based soak and Cidex OPA using an AER was performed. Participants were 'blinded' to the agent used for disinfection of the flexible cystoscopes. All patients had negative mid-stream urine at baseline, (MSU) no symptoms suggestive of urinary tract infection (UTI) on the day of investigation, no recent antibiotic use or current indwelling urinary catheter. Patients who underwent cystoscopic biopsy during the procedure were excluded. A urine analysis was done before and 3-5 days after cystoscopy and multiple equipment cultures were performed. The Urogenital Distress Inventory (UDI-6 + two questions from the 'long-form'), symptom and quality-of-life scores were assessed before and after cystoscopy as were ease-of-use assessments and a full cost analysis. In all, 180 of 465 screened participants were randomised 1:1 and the mean age was 72.1 years, 17% were females and 57% of procedures were performed for bladder tumour surveillance. The urine analysis was positive in 5.4% of patients in each group and 29% (Tristel) vs 20% (Cidex) of patients had urinary leukocyturia (p = ns) after cystoscopy. The turnover (minutes per cycle) was 7.5 (Tristel) vs 26.7 (Cidex). The per-procedure costs were $11.67 (American dollars) for Tristel Fuse and $21.82 for Cidex OPA with fixed costs of $4788 for Tristel Fuse and $60,514 for Cidex OPA. Tristel Fuse appears to be as effective and more cost-effective than Cidex OPA for high-level disinfection of flexible cystoscopes. This has significant cost implications for the office urologist. © 2013 The Authors. BJU International © 2013 BJU International.

  16. FORTRAN computer program for seismic risk analysis

    Science.gov (United States)

    McGuire, Robin K.

    1976-01-01

    A program for seismic risk analysis is described which combines generality of application, efficiency and accuracy of operation, and the advantage of small storage requirements. The theoretical basis for the program is first reviewed, and the computational algorithms used to apply this theory are described. The information required for running the program is listed. Published attenuation functions describing the variation with earthquake magnitude and distance of expected values for various ground motion parameters are summarized for reference by the program user. Finally, suggestions for use of the program are made, an example problem is described (along with example problem input and output) and the program is listed.

  17. Probabilistic Output Analysis by Program Manipulation

    DEFF Research Database (Denmark)

    Rosendahl, Mads; Kirkeby, Maja Hanne

    2015-01-01

    The aim of a probabilistic output analysis is to derive a probability distribution of possible output values for a program from a probability distribution of its input. We present a method for performing static output analysis, based on program transformation techniques. It generates a probability...

  18. Statis Program Analysis for Reliable, Trusted Apps

    Science.gov (United States)

    2017-02-01

    devices. App stores also provide a tempting vector for an attacker. An attacker can take advantage of bugdoors (software defects that permit...STATIC PROGRAM ANALYSIS FOR RELIABLE, TRUSTED APPS UNIVERSITY OF WASHINGTON FEBRUARY 2017 FINAL TECHNICAL REPORT APPROVED FOR PUBLIC RELEASE...STATIC PROGRAM ANALYSIS FOR RELIABLE, TRUSTED APPS 5a. CONTRACT NUMBER 5b. GRANT NUMBER FA8750-12-2-0107 5c. PROGRAM ELEMENT NUMBER 61101E 6. AUTHOR

  19. Copper deficiency alters cell bioenergetics and induces mitochondrial fusion through up-regulation of MFN2 and OPA1 in erythropoietic cells

    Energy Technology Data Exchange (ETDEWEB)

    Bustos, Rodrigo I.; Jensen, Erik L.; Ruiz, Lina M.; Rivera, Salvador; Ruiz, Sebastián [Center for Biomedical Research, Faculty of Biological Sciences and Faculty of Medicine, Universidad Andres Bello, Santiago (Chile); Simon, Felipe; Riedel, Claudia [Center for Biomedical Research, Faculty of Biological Sciences and Faculty of Medicine, Universidad Andres Bello, Santiago (Chile); Millennium Institute of Immunology and Immunotherapy, Santiago (Chile); Ferrick, David [Seahorse Bioscience, Billerica, MA (United States); Elorza, Alvaro A., E-mail: aelorza@unab.cl [Center for Biomedical Research, Faculty of Biological Sciences and Faculty of Medicine, Universidad Andres Bello, Santiago (Chile); Millennium Institute of Immunology and Immunotherapy, Santiago (Chile)

    2013-08-02

    Highlights: •In copper deficiency, cell proliferation is not affected. In turn, cell differentiation is impaired. •Enlarged mitochondria are due to up-regulation of MNF2 and OPA1. •Mitochondria turn off respiratory chain and ROS production. •Energy metabolism switch from mitochondria to glycolysis. -- Abstract: Copper is essential in cell physiology, participating in numerous enzyme reactions. In mitochondria, copper is a cofactor for respiratory complex IV, the cytochrome c oxidase. Low copper content is associated with anemia and the appearance of enlarged mitochondria in erythropoietic cells. These findings suggest a connection between copper metabolism and bioenergetics, mitochondrial dynamics and erythropoiesis, which has not been explored so far. Here, we describe that bathocuproine disulfonate-induced copper deficiency does not alter erythropoietic cell proliferation nor induce apoptosis. However it does impair erythroid differentiation, which is associated with a metabolic switch between the two main energy-generating pathways. That is, from mitochondrial function to glycolysis. Switching off mitochondria implies a reduction in oxygen consumption and ROS generation along with an increase in mitochondrial membrane potential. Mitochondrial fusion proteins MFN2 and OPA1 were up-regulated along with the ability of mitochondria to fuse. Morphometric analysis of mitochondria did not show changes in total mitochondrial biomass but rather bigger mitochondria because of increased fusion. Similar results were also obtained with human CD34+, which were induced to differentiate into red blood cells. In all, we have shown that adequate copper levels are important for maintaining proper mitochondrial function and for erythroid differentiation where the energy metabolic switch plus the up-regulation of fusion proteins define an adaptive response to copper deprivation to keep cells alive.

  20. Inclusiveness program - a SWOT analysis

    Science.gov (United States)

    Dósa, M.; Szegő, K.

    2017-09-01

    The Inclusiveness Program was created with the aim to integrate currently under-represented countries into the mainstream of European planetary research. Main stages of the working plan include setting up a database containing all the research institutes and universities where astronomical or geophysical research is carried out. It is necessary to identify their problems and needs. Challenging part of the project is to find exact means that help their work in a sustainable way. Strengths, weaknesses, opportunities and threats of the program were identified based on feedback from the inclusiveness community. Our conclusions, further suggestions are presented.

  1. Static Analysis of Mobile Programs

    Science.gov (United States)

    2017-02-01

    multiple layers of object-oriented abstractions. Our hypothesis has been that static analysis techniques have reached the point that sound, precise and...important features of STAMP are: • An interface for reading and interpreting DEX bytecode, allowing analysis of libraries in compiled form, both statically...describe a new bottom-up, subset-based, and context-sensitive pointer analysis for Java. The main novelty of our technique is the constraint-based handling

  2. Detection of the nonsense mutation of OPA3 gene in Holstein Friesian cattle with dilated cardiomyopathy in Japan

    Science.gov (United States)

    HORIUCHI, Noriyuki; KUMAGAI, Daishiro; MATSUMOTO, Kotaro; INOKUMA, Hisashi; FURUOKA, Hidefumi; KOBAYASHI, Yoshiyasu

    2015-01-01

    Bovine dilated cardiomyopathy (DCM) is an autosomal recessive genetic disorder causing congestive heart failure and subsequent death. Recently, a nonsense mutation c.343C>T in the bovine optic atrophy 3 (OPA3) gene had been reported to cause the DCM in Holstein cattle in Switzerland. However, the mutation has not been confirmed in bovine DCM outside Switzerland. Nine Holstein Friesian cows that were macroscopically and histologically diagnosed with or suspected of DCM and 12 control cows kept in Japan were tested for the mutation. The mutation surrounding OPA3 DNA fragment was amplified by PCR and subjected to direct sequences. The homogeneous c.343C>T mutation was proved to occur in all the affected cows and not in the control cows. The present study is the first report of the mutation in the DCM affected cows outside Switzerland. PMID:25947227

  3. Body mass index: different nutritional status according to WHO, OPAS and Lipschitz classifications in gastrointestinal cancer patients

    Directory of Open Access Journals (Sweden)

    Katia Barao

    2012-06-01

    Full Text Available CONTEXT: The body mass index (BMI is the most common marker used on diagnoses of the nutritional status. The great advantage of this index is the easy way to measure, the low cost, the good correlation with the fat mass and the association to morbidity and mortality. OBJECTIVE: To compare the BMI differences according to the WHO, OPAS and Lipschitz classification. METHODS: A prospective study on 352 patients with esophageal, gastric or colorectal cancer was done. The BMI was calculated and analyzed by the classification of WHO, Lipschitz and OPAS. RESULTS: The mean age was 62.1 ± 12.4 years and 59% of them had more than 59 years. The BMI had not difference between the genders in patients <59 years (P = 0.75, but over 59 years the BMI was higher in women (P<0.01. The percentage of undernourished was 7%, 18% and 21% (P<0.01 by WHO, Lipschitz and OPAS, respectively. The overweight/obesity was also different among the various classifications (P<0.01. CONCLUSIONS: Most of the patients with gastrointestinal cancer had more than 65 years. A different cut off must be used for this patients, because undernourished patients may be wrongly considered well nourished.

  4. SURE reliability analysis: Program and mathematics

    Science.gov (United States)

    Butler, Ricky W.; White, Allan L.

    1988-01-01

    The SURE program is a new reliability analysis tool for ultrareliable computer system architectures. The computational methods on which the program is based provide an efficient means for computing accurate upper and lower bounds for the death state probabilities of a large class of semi-Markov models. Once a semi-Markov model is described using a simple input language, the SURE program automatically computes the upper and lower bounds on the probability of system failure. A parameter of the model can be specified as a variable over a range of values directing the SURE program to perform a sensitivity analysis automatically. This feature, along with the speed of the program, makes it especially useful as a design tool.

  5. Energy Analysis Program 1990 annual report

    Energy Technology Data Exchange (ETDEWEB)

    1992-01-01

    The Energy Analysis Program has played an active role in the analysis and discussion of energy and environmental issues at several levels. (1) at the international level, with programs as developing scenarios for long-term energy demand in developing countries and organizing leading an analytic effort, ``Energy Efficiency, Developing Countries, and Eastern Europe,`` part of a major effort to increase support for energy efficiency programs worldwide; (2) at national level, the Program has been responsible for assessing energy forecasts and policies affecting energy use (e.g., appliance standards, National Energy Strategy scenarios); and (3) at the state and utility levels, the Program has been a leader in promoting integrated resource utility planning; the collaborative process has led to agreement on a new generation of utility demand-site programs in California, providing an opportunity to use knowledge and analytic techniques of the Program`s researchers. We continue to place highest on analyzing energy efficiency, with particular attention given to energy use in buildings. The Program continues its active analysis of international energy issues in Asia (including China), the Soviet Union, South America, and Western Europe. Analyzing the costs and benefits of different levels of standards for residential appliances continues to be the largest single area of research within the Program. The group has developed and applied techniques for forecasting energy demand (or constructing scenarios) for the United States. We have built a new model of industrial energy demand, are in the process of making major changes in our tools for forecasting residential energy demand, have built an extensive and documented energy conservation supply curve of residential energy use, and are beginning an analysis of energy-demand forecasting for commercial buildings.

  6. Constructing functional programs for grammar analysis problems

    NARCIS (Netherlands)

    Jeuring, J.T.; Swierstra, S.D.

    1995-01-01

    This paper discusses the derivation of functional programs for grammar analysis problems, such as the Empty problem and the Reachable problem. Grammar analysis problems can be divided into two classes: top-down problems such as Follow and Reachable, which are described in terms of the contexts of

  7. Energy Analysis Program 1990 annual report

    Energy Technology Data Exchange (ETDEWEB)

    1992-01-01

    The Energy Analysis Program has played an active role in the analysis and discussion of energy and environmental issues at several levels. (1) at the international level, with programs as developing scenarios for long-term energy demand in developing countries and organizing leading an analytic effort, Energy Efficiency, Developing Countries, and Eastern Europe,'' part of a major effort to increase support for energy efficiency programs worldwide; (2) at national level, the Program has been responsible for assessing energy forecasts and policies affecting energy use (e.g., appliance standards, National Energy Strategy scenarios); and (3) at the state and utility levels, the Program has been a leader in promoting integrated resource utility planning; the collaborative process has led to agreement on a new generation of utility demand-site programs in California, providing an opportunity to use knowledge and analytic techniques of the Program's researchers. We continue to place highest on analyzing energy efficiency, with particular attention given to energy use in buildings. The Program continues its active analysis of international energy issues in Asia (including China), the Soviet Union, South America, and Western Europe. Analyzing the costs and benefits of different levels of standards for residential appliances continues to be the largest single area of research within the Program. The group has developed and applied techniques for forecasting energy demand (or constructing scenarios) for the United States. We have built a new model of industrial energy demand, are in the process of making major changes in our tools for forecasting residential energy demand, have built an extensive and documented energy conservation supply curve of residential energy use, and are beginning an analysis of energy-demand forecasting for commercial buildings.

  8. Energy analysis program, FY 1979

    Science.gov (United States)

    1980-04-01

    Energy analysis attempts to understand the volitional choices of energy use and supply available to human society, and the multi-faceted consequences of choosing any one of them. Topics deal with economic impacts; assessments of regional issues and impacts; air quality evaluation; institutional and political issues in California power plant siting; assessment of environmental standards; water issues; characterization of aquatic systems dissolved oxygen profiles; modeling; computer-generated interactive graphics; energy assessment in Hawaii; solar energy in communities; utilities solar financial data; population impacts of geothermal development; energy conservation in colleges and residential sectors; energy policy; decision making; building energy performance standards; standards for residential appliances; and impact of energy performance standards on demand for peak electrical energy.

  9. Molecular Impairment Mechanisms of Novel OPA1 Mutations Predicted by Molecular Modeling in Patients With Autosomal Dominant Optic Atrophy and Auditory Neuropathy Spectrum Disorder.

    Science.gov (United States)

    Namba, Kazunori; Mutai, Hideki; Takiguchi, Yoichiro; Yagi, Hirotaka; Okuyama, Takahide; Oba, Shuntaro; Yamagishi, Ryosuke; Kaneko, Hiroki; Shintani, Tomoko; Kaga, Kimitaka; Matsunaga, Tatsuo

    2016-04-01

    Different missense mutations of the optic atrophy 1 gene (OPA1) identified in optic atrophy patients with auditory neuropathy spectrum disorder (ANSD) induce functional impairment through different molecular mechanisms. OPA1 is the gene responsible for autosomal dominant optic atrophy (ADOA), but some of its mutations are also associated with ANSD. OPA1 is a member of the GTPase family of proteins and plays a key role in the maintenance of mitochondrial activities that are dependent on dimer formation of the protein. There are many reports of OPA1 mutations, but the molecular mechanisms of their functional impairments are unclear. The sequences of coding regions in OPA1 were analyzed from blood samples of ADOA patients with ANSD. Molecular modeling of the protein's ability to form dimers and its GTP-binding ability were conducted to study the effects of structural changes in OPA1 caused by two identified mutations and their resultant effects on protein function. Two heterozygous mutations, p.T414P (c.1240A>C) and p.T540P (c.1618A>C), located in the GTPase and middle domains of OPA1, respectively, were identified in two patients. Molecular modeling indicated decreased dimer formation caused by destabilization of the association structure of the p.T414P mutant, and decreased GTP-binding caused by destabilization of the binding site structure in the p.T540P mutant. These two different conformational changes might result in decreased GTPase activities that trigger ADOA associated with ANSD, and are likely to be associated with mild clinical features. Molecular modeling would provide useful information in clinical practice.

  10. Utility Green Pricing Programs: A Statistical Analysis of Program Effectiveness

    Energy Technology Data Exchange (ETDEWEB)

    Wiser, R.; Olson, S.; Bird, L.; Swezey, B.

    2004-02-01

    This report analyzes actual utility green pricing program data to provide further insight into which program features might help maximize both customer participation in green pricing programs and the amount of renewable energy purchased by customers in those programs.

  11. Intrasystem Analysis Program (IAP) Model Improvement.

    Science.gov (United States)

    1982-02-01

    input impedance of ideal, lossless dipole antennas . Both the biconical and cylindri- cal dipoles, illustrated in Figure 2-2, were studied. a a h h ’I...on reverse ardde it neessary and 1~11’fff by block ambetf) Systems EMC Anaysis, Intrasystem Analysis Code, Frequency Le.- Antenna Models, Nonlinear...Receptor Models, Waveform Sensitive Rezept.;t, Spectral Models, Intrasystem EMC Analysis Program, Antenna Matching Factor, Trans- mission Line Loss

  12. Social network analysis for program implementation.

    Science.gov (United States)

    Valente, Thomas W; Palinkas, Lawrence A; Czaja, Sara; Chu, Kar-Hai; Brown, C Hendricks

    2015-01-01

    This paper introduces the use of social network analysis theory and tools for implementation research. The social network perspective is useful for understanding, monitoring, influencing, or evaluating the implementation process when programs, policies, practices, or principles are designed and scaled up or adapted to different settings. We briefly describe common barriers to implementation success and relate them to the social networks of implementation stakeholders. We introduce a few simple measures commonly used in social network analysis and discuss how these measures can be used in program implementation. Using the four stage model of program implementation (exploration, adoption, implementation, and sustainment) proposed by Aarons and colleagues [1] and our experience in developing multi-sector partnerships involving community leaders, organizations, practitioners, and researchers, we show how network measures can be used at each stage to monitor, intervene, and improve the implementation process. Examples are provided to illustrate these concepts. We conclude with expected benefits and challenges associated with this approach.

  13. Counter Trafficking System Development "Analysis Training Program"

    Energy Technology Data Exchange (ETDEWEB)

    Peterson, Dennis C. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2010-12-01

    This document will detail the training curriculum for the Counter-Trafficking System Development (CTSD) Analysis Modules and Lesson Plans are derived from the United States Military, Department of Energy doctrine and Lawrence Livermore National Laboratory (LLNL), Global Security (GS) S Program.

  14. Children's Animated TV Programs: A Content Analysis

    Science.gov (United States)

    Lambert, E. Beverley; Clancy, Susan

    2004-01-01

    This study describes the use of content analysis to develop a framework for analysing children's animated television programs (in this case, "Bob the Builder") and as such represents the initial stage of a larger project. Results indicate this popular TV series for preschoolers presents contradictory social messages about the roles of…

  15. The enhanced forest inventory and analysis program

    Science.gov (United States)

    Ronald E. McRoberts

    2005-01-01

    The Agricultural Research, Extension, and Education Reform Act of 1998 (Public Law 105–185), also known as the 1998 Farm Bill, prescribed conceptual changes in approaches to forest inventories conducted by the Forest Inventory and Analysis (FIA) Program of the U.S. Department of Agriculture (USDA) Forest Service. Realization of these conceptual changes required...

  16. Opas henkilökunnalle selkäleikkauspotilaan asentohoidosta heräämössä

    OpenAIRE

    Michelsson, Patrick; Bellaveglia, Laura

    2016-01-01

    Opinnäytetyömme tarkoitus oli tuottaa opas selkäleikkauspotilaan asentohoidon toteuttamisesta Jorvin sairaalan leikkaus- ja anestesiaosaston heräämön henkilökunnalle. Oppaan tarkoituksena on koota ydinasiat selkäleikkauspotilaan hyvän asentohoidon kannalta. Opinnäytetyön tavoitteena on kehittää selkäleikkauspotilaiden asentohoitoa heräämössä. Opinnäytetyö tehtiin osana Laurea-ammattikorkeakoulun ja HUS:n välistä Ohjaus hoitotyössä -hanketta. Toive opinnäytetyöaiheesta tuli Jorvin sairaalan le...

  17. Pienet kädet käyttöön - arjen opas vanhemmille, joiden lapsella on hemiplegia

    OpenAIRE

    Tammivuori, Kati

    2016-01-01

    Tämä opinnäytetyö käsittelee yläraajan kuntoutusta ja toimintaterapian keinoja alle 3 -vuotiaille lapsille, joilla on hemiplegia. Tavoitteena on helpottaa vanhempien toimimista kotona lapsen kanssa päivittäisissä tilanteissa ja leikissä. Lisäksi yhteistyökumppanin HYKS lastenneurologian toimintaterapian tavoite oli yhdenmukaistaa ja helpottaa vanhempien ohjaamista erikoissairaanhoidon tilanteissa. Opinnäytetyö rakentuu kahdesta osasta. ”Pikkuiset kädet käyttöön – arjen opas vanhemmille, ...

  18. Lasten peliriippuvuuden ehkäisy : Opas vanhempien ja kasvattajien käyttöön

    OpenAIRE

    Koivisto, Pasi; Kujansuu, Janne

    2013-01-01

    Opinnäytetyön tavoite oli tuottaa tietoa lapsen peliriippuvuuden ehkäisystä ja pelaamisen terveysriskeistä. Opinnäytetyön tarkoituksena oli soveltaa systemaattista kirjallisuuskatsausta tiedon kokoamiseen, jonka pohjalta tehtiin opas vanhemmille ja kasvattajille peliriippuvuuden ehkäisystä. Opasta voidaan jakaa kouluille sekä terveydenhuollon eri tahot voivat hyödyntää tuotoksen materiaalia jakaessaan tietoa kasvattajille ja vanhemmille. Opinnäytetyön tuloksista ilmeni, että lapsen liiall...

  19. Probabilistic Resource Analysis by Program Transformation

    DEFF Research Database (Denmark)

    Kirkeby, Maja Hanne; Rosendahl, Mads

    2016-01-01

    The aim of a probabilistic resource analysis is to derive a probability distribution of possible resource usage for a program from a probability distribution of its input. We present an automated multi-phase rewriting based method to analyze programs written in a subset of C. It generates...... a probability distribution of the resource usage as a possibly uncomputable expression and then transforms it into a closed form expression using over-approximations. We present the technique, outline the implementation and show results from experiments with the system....

  20. Static Analysis of Lockless Microcontroller C Programs

    Directory of Open Access Journals (Sweden)

    Eva Beckschulze

    2012-11-01

    Full Text Available Concurrently accessing shared data without locking is usually a subject to race conditions resulting in inconsistent or corrupted data. However, there are programs operating correctly without locking by exploiting the atomicity of certain operations on a specific hardware. In this paper, we describe how to precisely analyze lockless microcontroller C programs with interrupts by taking the hardware architecture into account. We evaluate this technique in an octagon-based value range analysis using access-based localization to increase efficiency.

  1. A Program Transformation for Backwards Analysis of Logic Programs

    DEFF Research Database (Denmark)

    Gallagher, John Patrick

    2003-01-01

    programs presented here is based on a transformation of the input program, which makes explicit the dependencies of the given program points on the initial goals. The transformation is derived from the resultants semantics of logic programs. The transformed program is then analysed using a standard...... framework and no special properties of the abstract domain....

  2. Análise da associação entre saneamento e saúde nos países da América Latina e do Caribe, empregando dados secundários do banco de dados da Organização Pan-Americana de Saúde - OPAS An analysis of the relationship between health and sanitation in Latin America and the Caribbean, using secondary data from PAHO - The Pan American Health Association

    Directory of Open Access Journals (Sweden)

    Júlio César Teixeira

    2005-12-01

    Full Text Available O presente estudo teve como objetivo avaliar a associação entre condições de saneamento - cobertura populacional por sistemas de abastecimento de água e por sistemas de esgotamento sanitário - e indicadores epidemiológicos - taxa de mortalidade infantil, mortalidade em menores de cinco anos de idade e mortalidade por enfermidades diarréicas agudas em menores de cinco anos de idade - nos países da América Latina e do Caribe, utilizando dados secundários da Organização Pan-Americana de Saúde - OPAS. O universo da pesquisa foi composto por 44 países integrantes da América Latina e do Caribe, com população total estimada de 561,3 milhões de habitantes, para o ano de 2005. O método epidemiológico empregado foi um delineamento ecológico. Pode-se afirmar que a universalização dos serviços de saneamento, a implantação de infra-estrutura urbana, o combate à desnutrição infantil e a ampliação da prevalência de aleitamento materno exclusivo até 120 dias de idade são medidas que contribuirão para a melhoria da saúde infantil na região.This study aimed to assess the relationship between sanitation conditions - population covered by water supply and sewerage services - and epidemiological indicators - infant mortality, mortality in children below 5, and mortality from acute diarrhoeal diseases in children below 5 - in Latin American and Caribbean countries, using secondary data from PAHO - the Pan American Health Organization. The research included 44 countries of Latin America and the Caribbean, with an estimated population of 561.3 million inhabitants in year 2005. The epidemiological method used was ecological delineation. It is possible to state that the universalization of sanitation services, implementation of urban infrastructure, fight against infant malnutrition, and increase in the prevalence of exclusive breastfeeding up to 120 days of life are actions that will contribute towards the improvement of infant

  3. Aspects with Program Analysis for Security Policies

    DEFF Research Database (Denmark)

    Yang, Fan

    with static program analysis techniques. The former technique can separate security concerns out of the main logic, and thus improves system modularity. The latter can analyze the system behavior, and thus helps detect software bugs or potential malicious code. We present AspectKE, an aspect......-oriented extensions based on KLAIM, followed by a discussion of open joinpoints that commonly exist in coordination languages such as KLAIM. Based on the idea of AspectKE, we design and implement a proof-of-concept programming language AspectKE*, which enables programmers to easily specify analysis-based security......Enforcing security policies to IT systems, especially for a mobile distributed system, is challenging. As society becomes more IT-savvy, our expectations about security and privacy evolve. This is usually followed by changes in regulation in the form of standards and legislation. In many cases...

  4. BRNI: Modular analysis of transcriptional regulatory programs

    Directory of Open Access Journals (Sweden)

    Nachman Iftach

    2009-05-01

    Full Text Available Abstract Background Transcriptional responses often consist of regulatory modules – sets of genes with a shared expression pattern that are controlled by the same regulatory mechanisms. Previous methods allow dissecting regulatory modules from genomics data, such as expression profiles, protein-DNA binding, and promoter sequences. In cases where physical protein-DNA data are lacking, such methods are essential for the analysis of the underlying regulatory program. Results Here, we present a novel approach for the analysis of modular regulatory programs. Our method – Biochemical Regulatory Network Inference (BRNI – is based on an algorithm that learns from expression data a biochemically-motivated regulatory program. It describes the expression profiles of gene modules consisting of hundreds of genes using a small number of regulators and affinity parameters. We developed an ensemble learning algorithm that ensures the robustness of the learned model. We then use the topology of the learned regulatory program to guide the discovery of a library of cis-regulatory motifs, and determined the motif compositions associated with each module. We test our method on the cell cycle regulatory program of the fission yeast. We discovered 16 coherent modules, covering diverse processes from cell division to metabolism and associated them with 18 learned regulatory elements, including both known cell-cycle regulatory elements (MCB, Ace2, PCB, ACCCT box and novel ones, some of which are associated with G2 modules. We integrate the regulatory relations from the expression- and motif-based models into a single network, highlighting specific topologies that result in distinct dynamics of gene expression in the fission yeast cell cycle. Conclusion Our approach provides a biologically-driven, principled way for deconstructing a set of genes into meaningful transcriptional modules and identifying their associated cis-regulatory programs. Our analysis sheds

  5. Energy Analysis Program. 1992 Annual report

    Energy Technology Data Exchange (ETDEWEB)

    1993-06-01

    The Program became deeply involved in establishing 4 Washington, D.C., project office diving the last few months of fiscal year 1942. This project office, which reports to the Energy & Environment Division, will receive the majority of its support from the Energy Analysis Program. We anticipate having two staff scientists and support personnel in offices within a few blocks of DOE. Our expectation is that this office will carry out a series of projects that are better managed closer to DOE. We also anticipate that our representation in Washington will improve and we hope to expand the Program, its activities, and impact, in police-relevant analyses. In spite of the growth that we have achieved, the Program continues to emphasize (1) energy efficiency of buildings, (2) appliance energy efficiency standards, (3) energy demand forecasting, (4) utility policy studies, especially integrated resource planning issues, and (5) international energy studies, with considerate emphasis on developing countries and economies in transition. These continuing interests are reflected in the articles that appear in this report.

  6. Sediment Analysis Using a Structured Programming Approach

    Directory of Open Access Journals (Sweden)

    Daniela Arias-Madrid

    2012-12-01

    Full Text Available This paper presents an algorithm designed for the analysis of a sedimentary sample of unconsolidated material and seeks to identify very quickly the main features that occur in a sediment and thus classify them fast and efficiently. For this purpose, it requires that the weight of each particle size to be entered in the program and using the method of Moments, which is based on four equations representing the mean, standard deviation, skewness and kurtosis, is found the attributes of the sample in few seconds. With the program these calculations are performed in an effective and more accurately way, obtaining also the explanations of the results of the features such as grain size, sorting, symmetry and origin, which helps to improve the study of sediments and in general the study of sedimentary rocks.

  7. 34 CFR 477.1 - What is the State Program Analysis Assistance and Policy Studies Program?

    Science.gov (United States)

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false What is the State Program Analysis Assistance and Policy Studies Program? 477.1 Section 477.1 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION STATE PROGRAM ANALYSIS ASSISTANCE AND POLICY STUDIES PROGRAM...

  8. Association of Neisseria gonorrhoeae Opa(CEA with dendritic cells suppresses their ability to elicit an HIV-1-specific T cell memory response.

    Directory of Open Access Journals (Sweden)

    Qigui Yu

    Full Text Available Infection with Neisseria gonorrhoeae (N. gonorrhoeae can trigger an intense local inflammatory response at the site of infection, yet there is little specific immune response or development of immune memory. Gonococcal surface epitopes are known to undergo antigenic variation; however, this is unlikely to explain the weak immune response to infection since individuals can be re-infected by the same serotype. Previous studies have demonstrated that the colony opacity-associated (Opa proteins on the N. gonorrhoeae surface can bind human carcinoembryonic antigen-related cellular adhesion molecule 1 (CEACAM1 on CD4⁺ T cells to suppress T cell activation and proliferation. Interesting in this regard, N. gonorrhoeae infection is associated with impaired HIV-1 (human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte (CTL responses and with transient increases in plasma viremia in HIV-1-infected patients, suggesting that N. gonorrhoeae may also subvert immune responses to co-pathogens. Since dendritic cells (DCs are professional antigen presenting cells (APCs that play a key role in the induction of an adaptive immune response, we investigated the effects of N. gonorrhoeae Opa proteins on human DC activation and function. While morphological changes reminiscent of DC maturation were evident upon N. gonorrhoeae infection, we observed a marked downregulation of DC maturation marker CD83 when the gonococci expressing CEACAM1-specific Opa(CEA, but not other Opa variants. Consistent with a gonococcal-induced defect in maturation, Opa(CEA binding to CEACAM1 reduced the DCs' capacity to stimulate an allogeneic T cell proliferative response. Moreover, Opa(CEA-expressing N. gonorrhoeae showed the potential to impair DC-dependent development of specific adaptive immunity, since infection with Opa(CEA-positive gonococci suppressed the ability of DCs to stimulate HIV-1-specific memory CTL responses. These results reveal a novel mechanism to explain

  9. A Spatial Analysis of Physician Assistant Programs.

    Science.gov (United States)

    Forister, J Glenn; Stilp, Curt

    2017-06-01

    The Accreditation Review Commission on Education for the Physician Assistant projects a total of 273 accredited programs by the summer of 2020. Over the past 10 years, the number of Central Application Service for Physician Assistants (CASPA) applicants per seat has increased by 53%. However, no studies have addressed the current geographic relationship of applicants to programs and program growth. The purpose of this study was to describe the geospatial patterns and relationships of physician assistant (PA) programs and CASPA applicants. Program directory information for established (n = 159), satellite (n = 18), and new PA programs (n = 95) was mapped using ArcGIS software. Permanent US ZIP codes for PA applicants (n = 22,603) from the 2014 to 2015 CASPA admissions cycle were also mapped. Point data were used to calculate the nearest neighbor by program type. Correlation was used to measure the association between PA applicants, program class size, and state population metrics. Most of the 95 new PA programs were geographically close to established programs. The median distance of new programs to the nearest neighboring established program was 25.6 miles (mean 39, standard deviation 38). Both established and new PA programs were found to be highly clustered (Moran's I z score < 2.58, p = .01). The geographic distribution of the CASPA applicant pool was related to distribution of the US population, certified PAs, and practicing physicians. PA program growth has exceeded projections. The close proximity of new programs to established programs will likely result in continued competition for quality applicants, PA faculty members, and clinical training sites.

  10. The Development of Practical Item Analysis Program for Indonesian Teachers

    Science.gov (United States)

    Muhson, Ali; Lestari, Barkah; Supriyanto; Baroroh, Kiromim

    2017-01-01

    Item analysis has essential roles in the learning assessment. The item analysis program is designed to measure student achievement and instructional effectiveness. This study was aimed to develop item-analysis program and verify its feasibility. This study uses a Research and Development (R & D) model. The procedure includes designing and…

  11. Biomedical Image Analysis by Program "Vision Assistant" and "Labview"

    Directory of Open Access Journals (Sweden)

    Peter Izak

    2005-01-01

    Full Text Available This paper introduces application in image analysis of biomedical images. General task is focused on analysis and diagnosis biomedical images obtained from program ImageJ. There are described methods which can be used for images in biomedical application. The main idea is based on particle analysis, pattern matching techniques. For this task was chosensophistication method by program Vision Assistant, which is a part of program LabVIEW.

  12. Integrated predictive maintenance program vibration and lube oil analysis: Part I - history and the vibration program

    Energy Technology Data Exchange (ETDEWEB)

    Maxwell, H.

    1996-12-01

    This paper is the first of two papers which describe the Predictive Maintenance Program for rotating machines at the Palo Verde Nuclear Generating Station. The organization has recently been restructured and significant benefits have been realized by the interaction, or {open_quotes}synergy{close_quotes} between the Vibration Program and the Lube Oil Analysis Program. This paper starts with the oldest part of the program - the Vibration Program and discusses the evolution of the program to its current state. The {open_quotes}Vibration{close_quotes} view of the combined program is then presented.

  13. Análisis Jurídico y Económico de la OPA de Gas Natural sobre Iberdrola

    Directory of Open Access Journals (Sweden)

    Javier de Quinto

    2003-09-01

    Full Text Available El 11 de marzo de 2003 Gas Natural SDG (GN acordó lanzar una OPA (Oferta pública de Adquisición a Acciones sobre Iberdrola, que fué notificada al Servicio de Defensa de la Competencia (SCD el 14 de marzo de 2003, y tuvo su entrada en el Tribunal de Defensa de la Competencia (TD el 24 de Abril de 2003. Esta responde a las tendencias que se estan produciendo ya en otros países, debido a la convergencia de los negocios de gas y electricidad. La OPA fue inmediatamente considerada hostil por la empresa eléctrica y sus principales accionistas. En este trabajo se analiza pormenorizadamente dicha operación, así como sus implicaciones para la futura competencia en el gas y en la electricidad, o la oportunidad que representa para la reestructuración empresarial del sector energético.

  14. [Tapio Mäkeläinen. Tapion matkassa Pärnuun ; Terhi Pääskylä-Malmström. Extreme Eesti -virollinen opas erilaiseen etelään] / Harri Rinne

    Index Scriptorium Estoniae

    Rinne, Harri, 1948-

    2012-01-01

    Arvustused: Mäkeläinen, Tapio. Tapion matkassa Pärnuun. Tallinn : Solnessi Arhitektuurikirjastus, 2012 ; Pääskylä-Malmström, Terhi. Extreme Eesti : virollinen opas erilaiseen etelään. Helsinki : Svalbooks, 2012

  15. Modulation of mitochondrial function and morphology by interaction of Omi/HtrA2 with the mitochondrial fusion factor OPA1

    Energy Technology Data Exchange (ETDEWEB)

    Kieper, Nicole; Holmstroem, Kira M.; Ciceri, Dalila; Fiesel, Fabienne C. [Center of Neurology and Hertie Institute for Clinical Brain Research, 72076 Tuebingen (Germany); Wolburg, Hartwig [Institute of Pathology, University of Tuebingen, 72076 Tuebingen (Germany); Ziviani, Elena; Whitworth, Alexander J. [Medical Research Council Centre for Developmental and Biomedical Genetics, University of Sheffield, Sheffield S10 2TN (United Kingdom); Martins, L. Miguel [Cell Death Regulation Laboratory, MRC Toxicology Unit, Leicester LE1 9HN (United Kingdom); Kahle, Philipp J., E-mail: philipp.kahle@uni-tuebingen.de [Center of Neurology and Hertie Institute for Clinical Brain Research, 72076 Tuebingen (Germany); Krueger, Rejko, E-mail: rejko.krueger@uni-tuebingen.de [Center of Neurology and Hertie Institute for Clinical Brain Research, 72076 Tuebingen (Germany)

    2010-04-15

    Loss of Omi/HtrA2 function leads to nerve cell loss in mouse models and has been linked to neurodegeneration in Parkinson's and Huntington's disease. Omi/HtrA2 is a serine protease released as a pro-apoptotic factor from the mitochondrial intermembrane space into the cytosol. Under physiological conditions, Omi/HtrA2 is thought to be involved in protection against cellular stress, but the cytological and molecular mechanisms are not clear. Omi/HtrA2 deficiency caused an accumulation of reactive oxygen species and reduced mitochondrial membrane potential. In Omi/HtrA2 knockout mouse embryonic fibroblasts, as well as in Omi/HtrA2 silenced human HeLa cells and Drosophila S2R+ cells, we found elongated mitochondria by live cell imaging. Electron microscopy confirmed the mitochondrial morphology alterations and showed abnormal cristae structure. Examining the levels of proteins involved in mitochondrial fusion, we found a selective up-regulation of more soluble OPA1 protein. Complementation of knockout cells with wild-type Omi/HtrA2 but not with the protease mutant [S306A]Omi/HtrA2 reversed the mitochondrial elongation phenotype and OPA1 alterations. Finally, co-immunoprecipitation showed direct interaction of Omi/HtrA2 with endogenous OPA1. Thus, we show for the first time a direct effect of loss of Omi/HtrA2 on mitochondrial morphology and demonstrate a novel role of this mitochondrial serine protease in the modulation of OPA1. Our results underscore a critical role of impaired mitochondrial dynamics in neurodegenerative disorders.

  16. SPAN C - Terminal sterilization process analysis program

    Science.gov (United States)

    1969-01-01

    Computer program, SPAN-C, measures the dry heat thermal sterilization process applied to a planetary capsule and calculates the time required for heat application, steady state conditions, and cooling. The program is based on the logarithmic survival of micro-organisms. Temperature profiles must be input on cards.

  17. SPAN - Terminal sterilization process analysis program

    Science.gov (United States)

    1969-01-01

    Computer program, SPAN, measures the dry heat thermal sterilization process applied to a planetary capsule and calculates the time required for heat application, steady state conditions, and cooling. The program is based on the logarithmic survival of micro-organisms. Temperature profiles must be input on tape.

  18. Entrepreneurship programs in developing countries : a meta regression analysis

    OpenAIRE

    Cho, Yoonyoung; Honorati, Maddalena

    2013-01-01

    This paper provides a synthetic and systematic review on the effectiveness of various entrepreneurship programs in developing countries. It adopts a meta-regression analysis using 37 impact evaluation studies that were in the public domain by March 2012, and draws out several lessons on the design of the programs. The paper observes wide variation in program effectiveness across different ...

  19. Social Network Analysis of the Farabi Exchange Program: Student Mobility

    Science.gov (United States)

    Ugurlu, Zeynep

    2016-01-01

    Problem Statement: Exchange programs offer communication channels created through student and instructor exchanges; a flow of information takes place through these channels. The Farabi Exchange Program (FEP) is a student and instructor exchange program between institutions of higher education. Through the use of social network analysis and…

  20. Program Spectra Analysis with Theory of Evidence

    Directory of Open Access Journals (Sweden)

    Rattikorn Hewett

    2012-01-01

    Full Text Available This paper presents an approach to automatically analyzing program spectra, an execution profile of program testing results for fault localization. Using a mathematical theory of evidence for uncertainty reasoning, the proposed approach estimates the likelihood of faulty locations based on evidence from program spectra. Our approach is theoretically grounded and can be computed online. Therefore, we can predict fault locations immediately after each test execution is completed. We evaluate the approach by comparing its performance with the top three performing fault localizers using a benchmark set of real-world programs. The results show that our approach is at least as effective as others with an average effectiveness (the reduction of the amount of code examined to locate a fault of 85.6% over 119 versions of the programs. We also study the quantity and quality impacts of program spectra on our approach where the quality refers to the spectra support in identifying that a certain unit is faulty. The results show that the effectiveness of our approach slightly improves with a larger number of failed runs but not with a larger number of passed runs. Program spectra with support quality increases from 1% to 100% improves the approach's effectiveness by 3.29%.

  1. A Sensitivity Analysis of the Rigid Pavement Life-Cycle Cost Analysis Program

    Science.gov (United States)

    2000-12-01

    Original Report Date: September 1999. This report describes the sensitivity analysis performed on the Rigid Pavement Life-Cycle Cost Analysis program, a computer program developed by the Center for Transportation Research for the Texas Department of ...

  2. Measurement and Analysis of P2P IPTV Program Resource

    Directory of Open Access Journals (Sweden)

    Wenxian Wang

    2014-01-01

    Full Text Available With the rapid development of P2P technology, P2P IPTV applications have received more and more attention. And program resource distribution is very important to P2P IPTV applications. In order to collect IPTV program resources, a distributed multi-protocol crawler is proposed. And the crawler has collected more than 13 million pieces of information of IPTV programs from 2009 to 2012. In addition, the distribution of IPTV programs is independent and incompact, resulting in chaos of program names, which obstructs searching and organizing programs. Thus, we focus on characteristic analysis of program resources, including the distributions of length of program names, the entropy of the character types, and hierarchy depth of programs. These analyses reveal the disorderly naming conventions of P2P IPTV programs. The analysis results can help to purify and extract useful information from chaotic names for better retrieval and accelerate automatic sorting of program and establishment of IPTV repository. In order to represent popularity of programs and to predict user behavior and popularity of hot programs over a period, we also put forward an analytical model of hot programs.

  3. Integrating computer programs for engineering analysis and design

    Science.gov (United States)

    Wilhite, A. W.; Crisp, V. K.; Johnson, S. C.

    1983-01-01

    The design of a third-generation system for integrating computer programs for engineering and design has been developed for the Aerospace Vehicle Interactive Design (AVID) system. This system consists of an engineering data management system, program interface software, a user interface, and a geometry system. A relational information system (ARIS) was developed specifically for the computer-aided engineering system. It is used for a repository of design data that are communicated between analysis programs, for a dictionary that describes these design data, for a directory that describes the analysis programs, and for other system functions. A method is described for interfacing independent analysis programs into a loosely-coupled design system. This method emphasizes an interactive extension of analysis techniques and manipulation of design data. Also, integrity mechanisms exist to maintain database correctness for multidisciplinary design tasks by an individual or a team of specialists. Finally, a prototype user interface program has been developed to aid in system utilization.

  4. Single-shell tank retrieval program mission analysis report

    Energy Technology Data Exchange (ETDEWEB)

    Stokes, W.J.

    1998-08-11

    This Mission Analysis Report was prepared to provide the foundation for the Single-Shell Tank (SST) Retrieval Program, a new program responsible for waste removal for the SSTS. The SST Retrieval Program is integrated with other Tank Waste Remediation System activities that provide the management, technical, and operations elements associated with planning and execution of SST and SST Farm retrieval and closure. This Mission Analysis Report provides the basis and strategy for developing a program plan for SST retrieval. This Mission Analysis Report responds to a US Department of Energy request for an alternative single-shell tank retrieval approach (Taylor 1997).

  5. Technical Analysis Program / Flight Standards Automation System -

    Data.gov (United States)

    Department of Transportation — 1-TAP is a national data quality application 2-Logbook is field office tracking and suspense program for investigation tracking and certification tracking 3-Numerous...

  6. The Development of Practical Item Analysis Program for Indonesian Teachers

    Directory of Open Access Journals (Sweden)

    Ali Muhson

    2017-04-01

    Full Text Available Item analysis has essential roles in the learning assessment. The item analysis program is designed to measure student achievement and instructional effectiveness. This study was aimed to develop item-analysis program and verify its feasibility. This study uses a Research and Development (R & D model. The procedure includes designing and developing a product, validating, and testing the product. The data were collected through documentations, questionnaires, and interviews. This study successfully developed item analysis program, namely AnBuso. It is developed based on classical test theory (CTT. It was practical and applicable for Indonesian teachers to analyse test items

  7. Studying creativity training programs: A methodological analysis

    DEFF Research Database (Denmark)

    Valgeirsdóttir, Dagný; Onarheim, Balder

    2017-01-01

    published since the seminal 2004 review. Focusing on quantitative studies of creativity training programs for adults, our systematic review resulted in 22 publications. All studies were analyzed, but comparing the reported effectiveness of training across studies proved difficult due to methodological...... inconsistencies, variations in reporting of results as well as types of measures used. Thus a consensus for future studies is called for to answer the question: Which elements make one creativity training program more effective than another? This is a question of equal relevance to academia and industry......, as creativity training is a tool that can contribute to enhancement of organizational creativity and subsequently innovation. However, to answer the question, future studies of creativity training programs need to be carefully designed to contribute to a more transparent landscape. Thus this paper proposes...

  8. Energy analysis program. 1994 annual report

    Energy Technology Data Exchange (ETDEWEB)

    Levine, M.D.

    1995-04-01

    This report provides an energy analysis overview. The following topics are described: building energy analysis; urban and energy environmental issues; appliance energy efficiency standards; utility planning and policy; energy efficiency, economics, and policy issues; and international energy and environmental issues.

  9. Programming effort analysis of the ELLPACK language

    Science.gov (United States)

    Rice, J. R.

    1978-01-01

    ELLPACK is a problem statement language and system for elliptic partial differential equations which is implemented by a FORTRAN preprocessor. ELLPACK's principal purpose is as a tool for the performance evaluation of software. However, it is used here as an example with which to study the programming effort required for problem solving. It is obvious that problem statement languages can reduce programming effort tremendously; the goal is to quantify this somewhat. This is done by analyzing the lengths and effort (as measured by Halstead's software science technique) of various approaches to solving these problems.

  10. New Programming Environments for Uncertainty Analysis

    Science.gov (United States)

    Hill, M. C.; Poeter, E. P.; Banta, E. R.; Christensen, S.; Cooley, R. L.; Ely, D. M.; Babendreier, J.; Leavesley, G.; Tonkin, M.; Julich, R.

    2005-12-01

    We live in a world of faster computers, better GUI's and visualization technology, increasing international cooperation made possible by new digital infrastructure, new agreements between US federal agencies (such as ISCMEM), new European Union programs (such as Harmoniqua), and greater collaboration between US university scientists through CUAHSI. These changes provide new resources for tackling the difficult job of quantifying how well our models perform. This talk introduces new programming environments that take advantage of these new developments and will change the paradigm of how we develop methods for uncertainty evaluation. For example, the programming environments provided by COSU API, JUPITER API, and Sensitivity/Optimization Toolbox provide enormous opportunities for faster and more meaningful evaluation of uncertainties. Instead of waiting years for ideas and theories to be compared in the complex circumstances of interest to resource managers, these new programming environments will expedite the process. In the new paradigm, unproductive ideas and theories will be revealed more quickly, productive ideas and theories will more quickly be used to address our increasingly difficult water resources problems. As examples, two ideas in JUPITER API applications are presented: uncertainty correction factors that account for system complexities not represented in models, and PPR and OPR statistics used to identify new data needed to reduce prediction uncertainty.

  11. Symbolic Analysis of Concurrent Programs with Polymorphism

    Science.gov (United States)

    Rungta, Neha Shyam

    2010-01-01

    The current trend of multi-core and multi-processor computing is causing a paradigm shift from inherently sequential to highly concurrent and parallel applications. Certain thread interleavings, data input values, or combinations of both often cause errors in the system. Systematic verification techniques such as explicit state model checking and symbolic execution are extensively used to detect errors in such systems [7, 9]. Explicit state model checking enumerates possible thread schedules and input data values of a program in order to check for errors [3, 9]. To partially mitigate the state space explosion from data input values, symbolic execution techniques substitute data input values with symbolic values [5, 7, 6]. Explicit state model checking and symbolic execution techniques used in conjunction with exhaustive search techniques such as depth-first search are unable to detect errors in medium to large-sized concurrent programs because the number of behaviors caused by data and thread non-determinism is extremely large. We present an overview of abstraction-guided symbolic execution for concurrent programs that detects errors manifested by a combination of thread schedules and data values [8]. The technique generates a set of key program locations relevant in testing the reachability of the target locations. The symbolic execution is then guided along these locations in an attempt to generate a feasible execution path to the error state. This allows the execution to focus in parts of the behavior space more likely to contain an error.

  12. Neural-specific deletion of Htra2 causes cerebellar neurodegeneration and defective processing of mitochondrial OPA1.

    Science.gov (United States)

    Patterson, Victoria L; Zullo, Alfred J; Koenig, Claire; Stoessel, Sean; Jo, Hakryul; Liu, Xinran; Han, Jinah; Choi, Murim; DeWan, Andrew T; Thomas, Jean-Leon; Kuan, Chia-Yi; Hoh, Josephine

    2014-01-01

    HTRA2, a serine protease in the intermembrane space, has important functions in mitochondrial stress signaling while its abnormal activity may contribute to the development of Parkinson's disease. Mice with a missense or null mutation of Htra2 fail to thrive, suffer striatal neuronal loss, and a parkinsonian phenotype that leads to death at 30-40 days of age. While informative, these mouse models cannot separate neural contributions from systemic effects due to the complex phenotypes of HTRA2 deficiency. Hence, we developed mice carrying a Htra2-floxed allele to query the consequences of tissue-specific HTRA2 deficiency. We found that mice with neural-specific deletion of Htra2 exhibited atrophy of the thymus and spleen, cessation to gain weight past postnatal (P) day 18, neurological symptoms including ataxia and complete penetrance of premature death by P40. Histologically, increased apoptosis was detected in the cerebellum, and to a lesser degree in the striatum and the entorhinal cortex, from P25. Even earlier at P20, mitochondria in the cerebella already exhibited abnormal morphology, including swelling, vesiculation, and fragmentation of the cristae. Furthermore, the onset of these structural anomalies was accompanied by defective processing of OPA1, a key molecule for mitochondrial fusion and cristae remodeling, leading to depletion of the L-isoform. Together, these findings suggest that HTRA2 is essential for maintenance of the mitochondrial integrity in neurons. Without functional HTRA2, a lifespan as short as 40 days accumulates a large quantity of dysfunctional mitochondria that contributes to the demise of mutant mice.

  13. Neural-specific deletion of Htra2 causes cerebellar neurodegeneration and defective processing of mitochondrial OPA1.

    Directory of Open Access Journals (Sweden)

    Victoria L Patterson

    Full Text Available HTRA2, a serine protease in the intermembrane space, has important functions in mitochondrial stress signaling while its abnormal activity may contribute to the development of Parkinson's disease. Mice with a missense or null mutation of Htra2 fail to thrive, suffer striatal neuronal loss, and a parkinsonian phenotype that leads to death at 30-40 days of age. While informative, these mouse models cannot separate neural contributions from systemic effects due to the complex phenotypes of HTRA2 deficiency. Hence, we developed mice carrying a Htra2-floxed allele to query the consequences of tissue-specific HTRA2 deficiency. We found that mice with neural-specific deletion of Htra2 exhibited atrophy of the thymus and spleen, cessation to gain weight past postnatal (P day 18, neurological symptoms including ataxia and complete penetrance of premature death by P40. Histologically, increased apoptosis was detected in the cerebellum, and to a lesser degree in the striatum and the entorhinal cortex, from P25. Even earlier at P20, mitochondria in the cerebella already exhibited abnormal morphology, including swelling, vesiculation, and fragmentation of the cristae. Furthermore, the onset of these structural anomalies was accompanied by defective processing of OPA1, a key molecule for mitochondrial fusion and cristae remodeling, leading to depletion of the L-isoform. Together, these findings suggest that HTRA2 is essential for maintenance of the mitochondrial integrity in neurons. Without functional HTRA2, a lifespan as short as 40 days accumulates a large quantity of dysfunctional mitochondria that contributes to the demise of mutant mice.

  14. Weather Analysis Programs Using HP-41CV.

    Science.gov (United States)

    1984-11-01

    LQT, 8DI; F;0M .Lz E. Program Table I Surface Winds Program. *#B - INV 181 VA~N 151 STO 18 FrX 0 1.3 102 1M8 152 GTO " GRPD " "CTR LT?" - / 193 + 153...LBL "EPST q, pkufMPT 5 8 184 STO 1 154 98.0 95 STO 0! 55 / 195 GTO "GRAD 155 STO 18 0j "CTP LOH!* 5 STO 18 I06#LBL "WSH" 156 GTO GRPD * 87 PPOMFPT 57...RCL 18 138 STO 18 1889LBL "ANTI* 39 RCL 7 89 X>Y’ 139 GTO * GRPD , !89 RCL 11 48 ENTERt 98 GTO *TWO* 1408L NOR* 198 RCL 25 41 RCL 88 91 !/X 141 368.8 191

  15. Static Complexity Analysis of Higher Order Programs

    DEFF Research Database (Denmark)

    Avery, James Emil; Kristiansen, Lars; Moyen, Jean-Yves

    2009-01-01

    The overall goal of the research presented in this paper is to find^Mautomatic methods for static complexity analysis of higher order^Mprograms.......The overall goal of the research presented in this paper is to find^Mautomatic methods for static complexity analysis of higher order^Mprograms....

  16. Pointer Analysis for JavaScript Programming Tools

    DEFF Research Database (Denmark)

    Feldthaus, Asger

    Tools that can assist the programmer with tasks, such as, refactoring or code navigation, have proven popular for Java, C#, and other programming languages. JavaScript is a widely used programming language, and its users could likewise benefit from such tools, but the dynamic nature of the language...... is an obstacle for the development of these. Because of this, tools for JavaScript have long remained ineffective compared to those for many other programming languages. Static pointer analysis can provide a foundation for more powerful tools, although the design of this analysis is itself a complicated endeavor....... In this work, we explore techniques for performing pointer analysis of JavaScript programs, and we find novel applications of these techniques. In particular, we demonstrate how these can be used for code navigation, automatic refactoring, semi-automatic refactoring of incomplete programs, and checking of type...

  17. A Review of CEFA Software: Comprehensive Exploratory Factor Analysis Program

    Science.gov (United States)

    Lee, Soon-Mook

    2010-01-01

    CEFA 3.02(Browne, Cudeck, Tateneni, & Mels, 2008) is a factor analysis computer program designed to perform exploratory factor analysis. It provides the main properties that are needed for exploratory factor analysis, namely a variety of factoring methods employing eight different discrepancy functions to be minimized to yield initial…

  18. On the relationship between regression analysis and mathematical programming

    OpenAIRE

    Dong Qian Wang; Stefanka Chukova; C. D. Lai

    2004-01-01

    The interaction between linear, quadratic programming and regression analysis are explored by both statistical and operations research methods. Estimation and optimization problems are formulated in two different ways: on one hand linear and quadratic programming problems are formulated and solved by statistical methods, and on the other hand the solution of the linear regression model with constraints makes use of the simplex methods of linear or quadratic programming. Example...

  19. Economic-Analysis Program for a Communication System

    Science.gov (United States)

    Chamberlain, R. G.

    1986-01-01

    Prices and profits of alternative designs compared. Objective of Land Mobile Satellite Service Finance Report (LMSS) program is to provide means for comparing alternative designs of LMSS systems. Program is Multiplan worksheet program. Labels used in worksheet chosen for satellite-based cellular communication service, but analysis not restricted to such cases. LMSS written for interactive execution with Multiplan (version 1.2) and implemented on IBM PC series computer operating under DOS (version 2.11).

  20. Quantitative Security Analysis for Multi-threaded Programs

    Directory of Open Access Journals (Sweden)

    Tri Minh Ngo

    2013-06-01

    Full Text Available Quantitative theories of information flow give us an approach to relax the absolute confidentiality properties that are difficult to satisfy for many practical programs. The classical information-theoretic approaches for sequential programs, where the program is modeled as a communication channel with only input and output, and the measure of leakage is based on the notions of initial uncertainty and remaining uncertainty after observing the final outcomes, are not suitable to multi-threaded programs. Besides, the information-theoretic approaches have been also shown to conflict with each other when comparing programs. Reasoning about the exposed information flow of multi-threaded programs is more complicated, since the outcomes of such programs depend on the scheduler policy, and the leakages in intermediate states also contribute to the overall leakage of the program. This paper proposes a novel model of quantitative analysis for multi-threaded programs that also takes into account the effect of observables in intermediate states along the trace. We define a notion of the leakage of a program trace. Given the fact that the execution of a multi-threaded program is typically described by a set of traces, the leakage of a program under a specific scheduler is computed as the expected value of the leakages of all possible traces. Examples are given to compare our approach with the existing approaches.

  1. FY2015 Analysis of the Teamwork USA Program. Memorandum

    Science.gov (United States)

    Howard, Mark

    2015-01-01

    The Department of Research and Evaluation (DRE) has completed an analysis of the performance of students who participated in the Teamwork USA Program, administered in FY2014 at three District schools. Teamwork USA hopes to improve student achievement at select Title I elementary schools via its Instrumental Music Program grant. This memorandum to…

  2. A Meta-Analysis of Outdoor Adventure Programming with Adolescents.

    Science.gov (United States)

    Cason, Dana; Gillis, H. L. Lee

    1994-01-01

    Meta-analysis of 143 effect sizes in 43 studies of adventure programming for adolescents found an overall effect size of 0.31. Summary effect sizes of outcome categories differed significantly among categories, however. Effect size was related to program length and participant age but not to delinquent status. Discusses the lack of pertinent…

  3. MULGRES: a computer program for stepwise multiple regression analysis

    Science.gov (United States)

    A. Jeff Martin

    1971-01-01

    MULGRES is a computer program source deck that is designed for multiple regression analysis employing the technique of stepwise deletion in the search for most significant variables. The features of the program, along with inputs and outputs, are briefly described, with a note on machine compatibility.

  4. A Computer Program for Short Circuit Analysis of Electric Power ...

    African Journals Online (AJOL)

    This paper described the mathematical basis and computational framework of a computer program developed for short circuit studies of electric power systems. The Short Circuit Analysis Program (SCAP) is to be used to assess the composite effects of unbalanced and balanced faults on the overall reliability of electric ...

  5. Hydrogeomorphic (HGM) Analysis : Natural Resource Program Center

    Data.gov (United States)

    US Fish and Wildlife Service, Department of the Interior — This factsheet describes hydrogeomorphic (HGM) analysis, a three-step process used to evaluate riparian and wetland ecosystems and surrounding landscapes.

  6. 2011 Biomass Program Platform Peer Review: Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Haq, Zia [Office of Energy Efficiency and Renewable Energy (EERE), Washington, DC (United States)

    2012-02-01

    This document summarizes the recommendations and evaluations provided by an independent external panel of experts at the 2011 U.S. Department of Energy Biomass Program’s Analysis Platform Review meeting.

  7. Automated Program Analysis for Cybersecurity (APAC)

    Science.gov (United States)

    2016-07-14

    person or corporation; or convey any rights or permission to manufacture , use , or sell any patented invention that may relate to them. This...UCSB, and Utah) requested that they be allowed to pre-process the applications used in Experiment 3B. The automated analysis tools from these teams...virtual machine server where participating teams could upload their tools and start their automated analysis. Teams using pre-computation were instructed

  8. An economic analysis methodology for project evaluation and programming.

    Science.gov (United States)

    2013-08-01

    Economic analysis is a critical component of a comprehensive project or program evaluation methodology that considers all key : quantitative and qualitative impacts of highway investments. It allows highway agencies to identify, quantify, and value t...

  9. Vulnerability and Risk Analysis Program: Overview of Assessment Methodology

    National Research Council Canada - National Science Library

    2001-01-01

    .... Over the last three years, a team of national laboratory experts, working in partnership with the energy industry, has successfully applied the methodology as part of OCIP's Vulnerability and Risk Analysis Program (VRAP...

  10. U.S. Geological Survey Gap Analysis Program

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — The Gap Analysis Program (GAP) is an element of the U.S. Geological Survey (USGS). GAP helps to implement the Department of Interior?s goals of inventory,...

  11. Safety and business benefit analysis of NASA's aviation safety program

    Science.gov (United States)

    2004-09-20

    NASA Aviation Safety Program elements encompass a wide range of products that require both public and private investment. Therefore, two methods of analysis, one relating to the public and the other to the private industry, must be combined to unders...

  12. Analysis and Implement of Broadcast Program Monitoring Data

    Directory of Open Access Journals (Sweden)

    Song Jin Bao

    2016-01-01

    Full Text Available With the rapid development of the radio and TV industry and the implementation of INT (the integration of telecommunications networks, cable TV networks and the Internet, the contents of programs and advertisements is showing massive, live and interactive trends. In order to meet the security of radio and television, the broadcast of information have to be controlled and administered. In order to master the latest information of public opinion trends through radio and television network, it is necessary research the specific industry applications of broadcast program monitoring. In this paper, the importance of broadcast monitoring in public opinion analysis is firstly analysed. The monitoring radio and television programs broadcast system architecture is proposed combining with the practice, focusing on the technical requirements and implementation process of program broadcast, advertisement broadcast and TV station broadcast monitoring. The more efficient information is generated through statistical analysis, which provides data analysis for radio and television public opinion analysis.

  13. Analysis of Defense Industry Consolidation Effects on Program Acquisition Costs

    National Research Council Canada - National Science Library

    Hoff, Russell V

    2007-01-01

    .... This thesis examines whether cost changes are evident following consolidation within the defense industry by conducting a regression analysis of Major Defense Acquisition Programs across 13 broad defense market sectors...

  14. Generalized Aliasing as a Basis for Program Analysis Tools

    National Research Council Canada - National Science Library

    O'Callahan, Robert

    2000-01-01

    .... This dissertation describes the design of a system, Ajax, that addresses this problem by using semantics-based program analysis as the basis for a number of different tools to aid Java programmers...

  15. Time Aquatic Resources Modeling and Analysis Program (STARMAP)

    Data.gov (United States)

    Federal Laboratory Consortium — Colorado State University has received funding from the U.S. Environmental Protection Agency (EPA) for its Space-Time Aquatic Resources Modeling and Analysis Program...

  16. Demonstration of a 100mJ OPO/OPA for future lidar applications and LIDT testing of optical components for MERLIN

    Science.gov (United States)

    Elsen, F.; Livrozet, M.; Strotkamp, M.; Wüppen, J.; Jungbluth, Bernd; Kasemann, R.; Löhring, J.; Meissner, A.; Meyer, Rudolf; Hoffmann, D.; Poprawe, R.

    2017-02-01

    In the field of atmospheric research, LIDAR is a powerful technology that can measure gas or aerosol concentrations, wind speed or temperature profiles remotely. To conduct such measurements globally, spaceborne systems are advantageous. Pulse energies in the 100 mJ range are required to achieve highly accurate, longitudinal resolved measurements. Measuring concentrations of specific gases, such as CH4 or CO2, requires output wavelengths in the IRB, which can be addressed by optical parametric frequency conversion. An OPO/OPA frequency conversion setup was designed and built as a demonstration module to address the 1.6 μm range. The pump laser is an Nd:YAG-MOPA system, consisting of a stable oscillator and two subsequent Innoslab-based amplifier stages that deliver up to 500 mJ of output pulse energy at 100 Hz repetition frequency. The OPO is inherited from the OPO design for the CH4 lidar instrument on the French-German climate satellite MERLIN. In order to address the 100 mJ regime, the OPO output beam is amplified in a subsequent multistage OPA. With KTP as nonlinear medium, the OPO/OPA delivered more than 100 mJ of output energy at 1645 nm from 450 mJ of the pump energy and a pump pulse duration of 30 ns. This corresponds to a quantum conversion efficiency of about 25 %. Besides demonstrating optical performance for future lidar systems, this laser will be part of a LIDT test facility, which will be used to qualify optical components especially for the MERLIN mission.

  17. Child sexual abuse prevention programs: a meta-analysis.

    Science.gov (United States)

    Davis, M K; Gidycz, C A

    2000-06-01

    Conducted a meta-analytic evaluation of the effectiveness of school-based child abuse prevention programs. Literature searches identified 27 studies meeting inclusion criteria for use in this meta-analysis. The average effect size for all programs studied was 1.07, indicating that children who participated in prevention programs performed 1.07 SD higher than control group children on the outcome measures used in the studies. Analysis of moderator variables revealed significant effects for age, number of sessions, participant involvement, type of outcome measure, and use of behavioral skills training. Most important, programs presented over 4 or more sessions that allowed children to become physically involved produced the highest effect sizes. Although most often used only with younger children, findings suggest that active, long-term programs may be more effective for children of all ages.

  18. Parceiro relutante: as relações do Canadá com a Organização Pan-Americana da Saúde (OPAS)

    OpenAIRE

    Klaudia Dmitrienko

    2006-01-01

    Apesar do forte compromisso ao multilateralismo e à cooperação internacional em saúde na era pós-Segunda Guerra Mundial, o Canadá absteve-se de ingressar na Organização Pan-Americana da Saúde - OPAS até 1971. Este artigo examina as explanações oficiais canadenses relativas aos fatores que retardaram esse ingresso, utilizando como fonte de análise cartas e memorandos trocados entre diplomatas e representantes governamentais canadenses. Esses fatores incluem a carência inicial de relações ofici...

  19. Digitaalinen opas Osuuspankin työntekijöille tietoisuuden lisäämiseksi blockchain-teknologiasta ja sen hyödyistä

    OpenAIRE

    Kangasmäki, Meeri

    2016-01-01

    Opinnäytetyö on laadittu toimeksiantona Osuuspankille. Opinnäytetyön toimeksiannon tavoitteena oli tuottaa opas blockchain-teknologiasta ja sen hyödyistä Osuuspankin työntekijöille. Oppaan tarkoituksena on lisätä ymmärrystä blockchain-teknologian toiminnasta ja sen käyttömahdollisuuksista. Blockchain-teknologia tulee muuttamaan finanssialaa lähitulevaisuudessa ja siksi siitä on tärkeä lisätä tietoisuutta alalla työskentelevien keskuudessa. Opinnäytetyössä esitellään blockchain-teknologian...

  20. "Cooking and Active Leisure" TAS Program, Spain: a Program Impact Pathways (PIP) analysis.

    Science.gov (United States)

    Roura, Elena; Pareja, Sara Lucía; Milá, Raimon; Cinca, Núria

    2014-09-01

    The "Cooking and Active Leisure" Tu y Alícia por la Salud (CAL-TAS) Program is a school-based pilot that addresses healthy lifestyle needs of Spanish secondary school students with initiatives that research has proven to improve dietary and physical activity behaviors. The objectives were to perform a Program Impact Pathways (PIP) analysis to describe key activities and processes of the CAL-TAS Program, identify Critical Quality Control Points (CCPs), and identify a suite of common indicators of healthy lifestyles to be applied across participant schools. The CAL-TAS Program designers and implementation team developed this PIP analysis through an iterative process and presented the results for feedback at the seven-country Healthy Lifestyles Program Evaluation Workshop held in Granada, Spain, 13-14 September 2013, under the auspices of the Mondelēz International Foundation. The team identified three PIP CCPs: teachers' motivation and training, changes in students' knowledge of healthy lifestyles, and changes in students' healthy lifestyle behavior. The selected indicators of the program's impact on healthy lifestyles are adequacy of food intake, level of knowledge of healthy lifestyles gained, and adequacy of physical activity level according to World Health Organization recommendations. A clear definition of impact indicators, as well as collection of accurate data on healthy lifestyle behaviors and knowledge, is essential to understanding the effectiveness of this program before it can be scaled up. CAL-TAS is an effective secondary school-based program encouraging healthy lifestyles. The PIP analysis was instrumental in identifying CCPs to sustain and improve the quality of the program. The team hopes to sustain and improve the program through these program evaluation recommendations.

  1. Software for Data Analysis Programming with R

    CERN Document Server

    Chambers, John

    2008-01-01

    Although statistical design is one of the oldest branches of statistics, its importance is ever increasing, especially in the face of the data flood that often faces statisticians. It is important to recognize the appropriate design, and to understand how to effectively implement it, being aware that the default settings from a computer package can easily provide an incorrect analysis. The goal of this book is to describe the principles that drive good design, paying attention to both the theoretical background and the problems arising from real experimental situations. Designs are motivated t

  2. Development of numerical modelling of analysis program for energy ...

    Indian Academy of Sciences (India)

    Taiwan. 2Department of Landscape Architecture, National Chin-Yi University of. Technology .... a design tool by engineers for the structural design of buildings, bridges, factories, industrial and public works, and .... cal analysis tool, the dynamic analysis program needs to be developed for energy design in accordance with ...

  3. SSL Pricing and Efficacy Trend Analysis for Utility Program Planning

    Energy Technology Data Exchange (ETDEWEB)

    Tuenge, J. R. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2013-10-01

    Report to help utilities and energy efficiency organizations forecast the order in which important SSL applications will become cost-effective and estimate when each "tipping point" will be reached. Includes performance trend analysis from DOE's LED Lighting Facts® and CALiPER programs plus cost analysis from various sources.

  4. Development of educational program for neutron activation analysis

    Energy Technology Data Exchange (ETDEWEB)

    Chung, Yong Sam; Moon, Jong Hwa; Kim, Sun Ha; Ryel, Sung; Kang, Young Hwan; Lee, Kil Yong; Yeon, Yeon Yel; Cho, Seung Yeon

    2000-08-01

    This technical report is developed to apply an educational and training program for graduate student and analyst utilizing neutron activation analysis. The contents of guide book consists of five parts as follows; introduction, gamma-ray spectrometry and measurement statistics, its applications, to understand of comprehensive methodology and to utilize a relevant knowledge and information on neutron activation analysis.

  5. Complexity and information flow analysis for multi-threaded programs

    Science.gov (United States)

    Ngo, Tri Minh; Huisman, Marieke

    2017-07-01

    This paper studies the security of multi-threaded programs. We combine two methods, i.e., qualitative and quantitative security analysis, to check whether a multi-threaded program is secure or not. In this paper, besides reviewing classical analysis models, we present a novel model of quantitative analysis where the attacker is able to select the scheduling policy. This model does not follow the traditional information-theoretic channel setting. Our analysis first studies what extra information an attacker can get if he knows the scheduler's choices, and then integrates this information into the transition system modeling the program execution. Via a case study, we compare this approach with the traditional information-theoretic models, and show that this approach gives more intuitive-matching results.

  6. Energy analysis program. 1995 Annual report

    Energy Technology Data Exchange (ETDEWEB)

    Levine, M.D.

    1996-05-01

    This year the role of energy technology research and analysis supporting governmental and public interests is again being challenged at high levels of government. This situation is not unlike that of the early 1980s, when the Administration questioned the relevance of a federal commitment to applied energy research, especially for energy efficiency and renewable energy technologies. Then Congress continued to support such activities, deeming them important to the nation`s interest. Today, Congress itself is challenging many facets of the federal role in energy. The Administration is also selectively reducing its support, primarily for the pragmatic objective of reducing federal expenditures, rather than because of principles opposing a public role in energy. this report is divided into three sections: International Energy and the global environment; Energy, economics, markets, and policy; and Buildings and their environment.

  7. Computer programs for analysis of geophysical data

    Energy Technology Data Exchange (ETDEWEB)

    Rozhkov, M.; Nakanishi, K.

    1994-06-01

    This project is oriented toward the application of the mobile seismic array data analysis technique in seismic investigations of the Earth (the noise-array method). The technique falls into the class of emission tomography methods but, in contrast to classic tomography, 3-D images of the microseismic activity of the media are obtained by passive seismic antenna scanning of the half-space, rather than by solution of the inverse Radon`s problem. It is reasonable to expect that areas of geothermal activity, active faults, areas of volcanic tremors and hydrocarbon deposits act as sources of intense internal microseismic activity or as effective sources for scattered (secondary) waves. The conventional approaches of seismic investigations of a geological medium include measurements of time-limited determinate signals from artificial or natural sources. However, the continuous seismic oscillations, like endogenous microseisms, coda and scattering waves, can give very important information about the structure of the Earth. The presence of microseismic sources or inhomogeneities within the Earth results in the appearance of coherent seismic components in a stochastic wave field recorded on the surface by a seismic array. By careful processing of seismic array data, these coherent components can be used to develop a 3-D model of the microseismic activity of the media or images of the noisy objects. Thus, in contrast to classic seismology where narrow windows are used to get the best time resolution of seismic signals, our model requires long record length for the best spatial resolution.

  8. Forest inventory and analysis: a national inventory and monitoring program.

    Science.gov (United States)

    Smith, W Brad

    2002-01-01

    Forests provide significant commodity and noncommodity values to the citizens of the United States. An important and substantial role in ensuring the continued health, productivity, and sustainability of these resources is a reliable and credible inventory and monitoring program. The Forest Inventory and Analysis (FIA) program of the US Forest Service has been monitoring and reporting on status, condition, and trends in the nation's forests for over 70 years and the Forest Health Monitoring (FHM) program for the last 11 years. Recent legislation included in the 1998 Farm Bill, along with efforts to integrate inventory and monitoring networks to deliver Criteria and Indicators of Sustainable Forests, are redefining the role and operation of the recently integrated FIA and FHM programs. This paper provides a brief history and a look at new directions for the enhanced FIA Program.

  9. A comparative analysis of influenza vaccination programs.

    Directory of Open Access Journals (Sweden)

    Shweta Bansal

    2006-10-01

    Full Text Available BACKGROUND: The threat of avian influenza and the 2004-2005 influenza vaccine supply shortage in the United States have sparked a debate about optimal vaccination strategies to reduce the burden of morbidity and mortality caused by the influenza virus. METHODS AND FINDINGS: We present a comparative analysis of two classes of suggested vaccination strategies: mortality-based strategies that target high-risk populations and morbidity-based strategies that target high-prevalence populations. Applying the methods of contact network epidemiology to a model of disease transmission in a large urban population, we assume that vaccine supplies are limited and then evaluate the efficacy of these strategies across a wide range of viral transmission rates and for two different age-specific mortality distributions. We find that the optimal strategy depends critically on the viral transmission level (reproductive rate of the virus: morbidity-based strategies outperform mortality-based strategies for moderately transmissible strains, while the reverse is true for highly transmissible strains. These results hold for a range of mortality rates reported for prior influenza epidemics and pandemics. Furthermore, we show that vaccination delays and multiple introductions of disease into the community have a more detrimental impact on morbidity-based strategies than mortality-based strategies. CONCLUSIONS: If public health officials have reasonable estimates of the viral transmission rate and the frequency of new introductions into the community prior to an outbreak, then these methods can guide the design of optimal vaccination priorities. When such information is unreliable or not available, as is often the case, this study recommends mortality-based vaccination priorities.

  10. PAN network analysis program: its development and use

    Energy Technology Data Exchange (ETDEWEB)

    Goldwater, M.H.; Rogers, K.; Turnbull, D.K.

    1976-01-01

    British Gas Corp.'s London Research Station describes a comprehensive, efficient, and flexible computer simulation of pressure and flows in gas networks known as PAN - Program to Analyze Networks. The program is used extensively throughout the BGC system for both design and control of gas transmission grids. Its powerful method of analysis solves network problems quickly and handles complex configurations of compressors and regulators easily.

  11. Two Programs for Supersonic Wing Design and Analysis

    Science.gov (United States)

    Mason, W. H.; Rosen, B. S.; Grossman, B.

    1986-01-01

    COREL and W12SC3 useful in aerodynamic design and analysis of wings for supersonic speeds. COREL (Conical Relaxation) program solves nonlinear full potential equation for spanwise section of wing in crossflow plane, and option exists to correct result for nonconical geometry. W12SC3 applies lineartheory panel methods to compute solutions for wing/body configuration. Programs restricted to supersonic flows and useful for many design, analysis, and optimization applications. COREL and W12SC3 written in FORTRAN IV for batch execution.

  12. FASP, an analytic resource appraisal program for petroleum play analysis

    Science.gov (United States)

    Crovelli, R.A.; Balay, R.H.

    1986-01-01

    An analytic probabilistic methodology for resource appraisal of undiscovered oil and gas resources in play analysis is presented in a FORTRAN program termed FASP. This play-analysis methodology is a geostochastic system for petroleum resource appraisal in explored as well as frontier areas. An established geologic model considers both the uncertainty of the presence of the assessed hydrocarbon and its amount if present. The program FASP produces resource estimates of crude oil, nonassociated gas, dissolved gas, and gas for a geologic play in terms of probability distributions. The analytic method is based upon conditional probability theory and many laws of expectation and variance. ?? 1986.

  13. Bounded Delay Timing Analysis of a Class of CSP Programs

    DEFF Research Database (Denmark)

    Hulgaard, Henrik; Burns, Steven M.

    1997-01-01

    . Such a description is transformed into a safe Petri net with interval time delays specified on the places of the net. The timing analysis we perform determines the extreme separation in time between two communication actions of the CSP program for all possible timed executions of the system. We formally define......We describe an algebraic technique for performing timing analysis of a class of asynchronous circuits described as CSP programs (including Martin's probe operator) with the restrictions that there is no OR-causality and that guard selection is either completely free or mutually exclusive...

  14. Language-Agnostic Reproducible Data Analysis Using Literate Programming.

    Directory of Open Access Journals (Sweden)

    Boris Vassilev

    Full Text Available A modern biomedical research project can easily contain hundreds of analysis steps and lack of reproducibility of the analyses has been recognized as a severe issue. While thorough documentation enables reproducibility, the number of analysis programs used can be so large that in reality reproducibility cannot be easily achieved. Literate programming is an approach to present computer programs to human readers. The code is rearranged to follow the logic of the program, and to explain that logic in a natural language. The code executed by the computer is extracted from the literate source code. As such, literate programming is an ideal formalism for systematizing analysis steps in biomedical research. We have developed the reproducible computing tool Lir (literate, reproducible computing that allows a tool-agnostic approach to biomedical data analysis. We demonstrate the utility of Lir by applying it to a case study. Our aim was to investigate the role of endosomal trafficking regulators to the progression of breast cancer. In this analysis, a variety of tools were combined to interpret the available data: a relational database, standard command-line tools, and a statistical computing environment. The analysis revealed that the lipid transport related genes LAPTM4B and NDRG1 are coamplified in breast cancer patients, and identified genes potentially cooperating with LAPTM4B in breast cancer progression. Our case study demonstrates that with Lir, an array of tools can be combined in the same data analysis to improve efficiency, reproducibility, and ease of understanding. Lir is an open-source software available at github.com/borisvassilev/lir.

  15. Language-Agnostic Reproducible Data Analysis Using Literate Programming.

    Science.gov (United States)

    Vassilev, Boris; Louhimo, Riku; Ikonen, Elina; Hautaniemi, Sampsa

    2016-01-01

    A modern biomedical research project can easily contain hundreds of analysis steps and lack of reproducibility of the analyses has been recognized as a severe issue. While thorough documentation enables reproducibility, the number of analysis programs used can be so large that in reality reproducibility cannot be easily achieved. Literate programming is an approach to present computer programs to human readers. The code is rearranged to follow the logic of the program, and to explain that logic in a natural language. The code executed by the computer is extracted from the literate source code. As such, literate programming is an ideal formalism for systematizing analysis steps in biomedical research. We have developed the reproducible computing tool Lir (literate, reproducible computing) that allows a tool-agnostic approach to biomedical data analysis. We demonstrate the utility of Lir by applying it to a case study. Our aim was to investigate the role of endosomal trafficking regulators to the progression of breast cancer. In this analysis, a variety of tools were combined to interpret the available data: a relational database, standard command-line tools, and a statistical computing environment. The analysis revealed that the lipid transport related genes LAPTM4B and NDRG1 are coamplified in breast cancer patients, and identified genes potentially cooperating with LAPTM4B in breast cancer progression. Our case study demonstrates that with Lir, an array of tools can be combined in the same data analysis to improve efficiency, reproducibility, and ease of understanding. Lir is an open-source software available at github.com/borisvassilev/lir.

  16. The environment power system analysis tool development program

    Science.gov (United States)

    Jongeward, Gary A.; Kuharski, Robert A.; Kennedy, Eric M.; Stevens, N. John; Putnam, Rand M.; Roche, James C.; Wilcox, Katherine G.

    1990-01-01

    The Environment Power System Analysis Tool (EPSAT) is being developed to provide space power system design engineers with an analysis tool for determining system performance of power systems in both naturally occurring and self-induced environments. The program is producing an easy to use computer aided engineering (CAE) tool general enough to provide a vehicle for technology transfer from space scientists and engineers to power system design engineers. The results of the project after two years of a three year development program are given. The EPSAT approach separates the CAE tool into three distinct functional units: a modern user interface to present information, a data dictionary interpreter to coordinate analysis; and a data base for storing system designs and results of analysis.

  17. Navy Family Advocacy Program. Appendix. Analysis of Central Registry Reports.

    Science.gov (United States)

    1983-12-01

    2/76) 2 Suspected Abuzso/Malect/Sexua1 Assault an ae2404 65.) "Suspected Abuso /Neglect/ Sexual Assault and Rape Report" 2226 60.5 NAVMED 6320/15A...ANALYSIS OF SEXUAL ASSAULT REPORTS ........... 50 HAPTER V: SUMAY ANALYSIS Or rAMILY ADVOCACY PROGRAM REPORTS . 56 APPENDIX...cont’d)I PAGE CHAPTER IV: SEXUAL ASSAULT TV-1 Fore . . . . . . . . . . . . . . . . . . . . . 51 IV-2 Type of Maltreatment ............... 53 IV-3

  18. Robust Sensitivity Analysis of the Optimal Value of Linear Programming

    OpenAIRE

    Xu, Guanglin; Burer, Samuel

    2015-01-01

    We propose a framework for sensitivity analysis of linear programs (LPs) in minimization form, allowing for simultaneous perturbations in the objective coefficients and right-hand sides, where the perturbations are modeled in a compact, convex uncertainty set. This framework unifies and extends multiple approaches for LP sensitivity analysis in the literature and has close ties to worst-case linear optimization and two-stage adaptive optimization. We define the minimum (best-case) and maximum...

  19. Design on an enhanced interactive satellite communications system analysis program

    Science.gov (United States)

    Andersen, Kevin Robert

    1991-09-01

    This thesis describes the design of a user-friendly interactive satellite communications analysis program for use on a personal computer. The user inputs the various parameters of a satellite orbit, ground station location and communications equipment. The output generated allows a user to view the satellite ground trace and footprint, calculate satellite rise and set times, and analyze the performance of the communications link. The link analysis allows the user to input various signal losses and jamming interference. Care was taken to ensure that the program is simple to operate and that it provides on-line help for each segment. A principle goal of this thesis effort is to provide an educational tool that familiarizes the user with the communications segment of a space system. The initial success of the program based upon student response validates the use of object-oriented like software tools that enhance user understanding of complex subjects.

  20. Systems Analysis of NASA Aviation Safety Program: Final Report

    Science.gov (United States)

    Jones, Sharon M.; Reveley, Mary S.; Withrow, Colleen A.; Evans, Joni K.; Barr, Lawrence; Leone, Karen

    2013-01-01

    A three-month study (February to April 2010) of the NASA Aviation Safety (AvSafe) program was conducted. This study comprised three components: (1) a statistical analysis of currently available civilian subsonic aircraft data from the National Transportation Safety Board (NTSB), the Federal Aviation Administration (FAA), and the Aviation Safety Information Analysis and Sharing (ASIAS) system to identify any significant or overlooked aviation safety issues; (2) a high-level qualitative identification of future safety risks, with an assessment of the potential impact of the NASA AvSafe research on the National Airspace System (NAS) based on these risks; and (3) a detailed, top-down analysis of the NASA AvSafe program using an established and peer-reviewed systems analysis methodology. The statistical analysis identified the top aviation "tall poles" based on NTSB accident and FAA incident data from 1997 to 2006. A separate examination of medical helicopter accidents in the United States was also conducted. Multiple external sources were used to develop a compilation of ten "tall poles" in future safety issues/risks. The top-down analysis of the AvSafe was conducted by using a modification of the Gibson methodology. Of the 17 challenging safety issues that were identified, 11 were directly addressed by the AvSafe program research portfolio.

  1. Students' Needs Analysis in an EFL Program for University Professors

    Science.gov (United States)

    Bedoya, Paula Andrea; Valencia, Luz María; Montoya, Juan Carlos

    2016-01-01

    This study sets out to investigate professors' needs from an English as a foreign language program in a public university regarding demands, interests, and lacks based on the methodology of needs analysis. Data collected through a survey, focus groups, and individual interviews showed that professors need to meet the institutional language policy…

  2. Decision analysis of the Liquid Metal Fast Breeder Reactor program

    Energy Technology Data Exchange (ETDEWEB)

    Seim, E.H.

    1983-01-01

    The decision-analysis methodology is employed to develop a model to examine the Liquid Metal Fast Breeder Reactor Program to provide guidance for US decision makers. Information relative to the nuclear fuel cycle, the decision analysis technique, and the supporting economic theory is provided for background purposes. The model consists of four courses of action, three decision times, and five critical factors with either two or three paths leading to 198 possible end results. The courses of action cover a range of the possible programs to develop a commercial LMFBR including scale-up, program timing, and plant schedules. Data developed from a number of recent studies along with probability assignments from three sources are run through the model and indicate that course of action one (Compressed Full Program) produces the greatest net benefits discounted to a present value at a real rate of 5%. An analysis is included to consider the foregone costs of coal usage for electrical generation when LMFBR capacity could be available. Ranking of the courses of action does not change compared to the analysis without foregone costs. The foregone costs are approximately five times greater than the LMFBR benefits alone. Recommendations for specific actions by decision makers conclude the study.

  3. Supporting secure programming in web applications through interactive static analysis.

    Science.gov (United States)

    Zhu, Jun; Xie, Jing; Lipford, Heather Richter; Chu, Bill

    2014-07-01

    Many security incidents are caused by software developers' failure to adhere to secure programming practices. Static analysis tools have been used to detect software vulnerabilities. However, their wide usage by developers is limited by the special training required to write rules customized to application-specific logic. Our approach is interactive static analysis, to integrate static analysis into Integrated Development Environment (IDE) and provide in-situ secure programming support to help developers prevent vulnerabilities during code construction. No additional training is required nor are there any assumptions on ways programs are built. Our work is motivated in part by the observation that many vulnerabilities are introduced due to failure to practice secure programming by knowledgeable developers. We implemented a prototype interactive static analysis tool as a plug-in for Java in Eclipse. Our technical evaluation of our prototype detected multiple zero-day vulnerabilities in a large open source project. Our evaluations also suggest that false positives may be limited to a very small class of use cases.

  4. Supporting secure programming in web applications through interactive static analysis

    Directory of Open Access Journals (Sweden)

    Jun Zhu

    2014-07-01

    Full Text Available Many security incidents are caused by software developers’ failure to adhere to secure programming practices. Static analysis tools have been used to detect software vulnerabilities. However, their wide usage by developers is limited by the special training required to write rules customized to application-specific logic. Our approach is interactive static analysis, to integrate static analysis into Integrated Development Environment (IDE and provide in-situ secure programming support to help developers prevent vulnerabilities during code construction. No additional training is required nor are there any assumptions on ways programs are built. Our work is motivated in part by the observation that many vulnerabilities are introduced due to failure to practice secure programming by knowledgeable developers. We implemented a prototype interactive static analysis tool as a plug-in for Java in Eclipse. Our technical evaluation of our prototype detected multiple zero-day vulnerabilities in a large open source project. Our evaluations also suggest that false positives may be limited to a very small class of use cases.

  5. 7 CFR 1700.32 - Program Accounting and Regulatory Analysis.

    Science.gov (United States)

    2010-01-01

    ... accounting and financial services with respect to electric and telecommunications borrowers and directs and... standards of the Financial Accounting Standards Board, and recommends Agency policies and procedures. (d... 7 Agriculture 11 2010-01-01 2010-01-01 false Program Accounting and Regulatory Analysis. 1700.32...

  6. Analysis of Logic Programs Using Regular Tree Languages

    DEFF Research Database (Denmark)

    Gallagher, John Patrick

    2012-01-01

    The eld of nite tree automata provides fundamental notations and tools for reasoning about set of terms called regular or recognizable tree languages. We consider two kinds of analysis using regular tree languages, applied to logic programs. The rst approach is to try to discover automatically...

  7. Data Quality Assurance Program Plan for NRC Division of Risk Analysis Programs at the INL

    Energy Technology Data Exchange (ETDEWEB)

    Sattison, Martin B. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Wierman, Thomas E. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Vedros, Kurt G. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Germain, Shawn W. St. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Eide, Steven A. [Idaho National Lab. (INL), Idaho Falls, ID (United States); Sant, Robert L. [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2009-07-01

    The Division of Risk Analysis (DRA), Office of Nuclear Regulatory Research (RES), must ensure that the quality of the data that feed into its programs follow Office of Management and Budget (OMB) and U.S. Nuclear Regulatory Commission (NRC) guidelines and possibly other standards and guidelines used in nuclear power plant risk analyses. This report documents the steps taken in DRA’s Data Quality Improvement project (Job Control Number N6145) to develop a Data Quality Assurance Program Plan. These steps were 1. Conduct a review of data quality requirements 2. Review current data programs, products, and data quality control activities 3. Review the Institute of Nuclear Power Operation (INPO) Equipment Performance and Information Exchange (EPIX) data quality programs and characterize the EPIX data quality and uncertainty 4. Compare these programs, products, and activities against the requirements 5. Develop a program plan that provides assurance that data quality is being maintained. It is expected that the Data Quality Assurance Program Plan will be routinely implemented in all aspects of future data collection and processing efforts and that specific portions will be executed annually to provide assurance that data quality is being maintained.

  8. Analysis of TPU education programs content corresponding to systems engineering principles

    OpenAIRE

    Воронова, Гульнара Альфридовна; Ефременков, Егор Алексеевич

    2014-01-01

    Analysis of 25 Master education programs has been done. Three groups of technical Master education programs has been evaluated differ in content. As a result of analysis the integration of systems engineering principles in education master programs will be continued.

  9. System Safety Analysis Application Guide. Safety Analysis Report Update Program

    Energy Technology Data Exchange (ETDEWEB)

    1993-05-01

    Martin Marietta Energy Systems, Inc., (Energy Systems) is committed to performing and documenting safety analyses for facilities it manages for the Department of Energy (DOE). Safety analyses are performed to identify hazards and potential accidents; to analyze the adequacy of measures taken to eliminate, control, or mitigate hazards; and to evaluate potential accidents and determine associated risks. Safety Analysis Reports (SARs) are prepared to document the safety analysis to ensure facilities can be operated safely and in accordance with regulations. SARs include Technical Safety Requirements (TSRs), which are specific technical and administrative requirements that prescribe limits and controls to ensure safe operation of DOE facilities. These documented descriptions and analyses contribute to the authorization basis for facility operation. Energy Systems has established a process to perform Unreviewed Safety Question Determinations (USQDs) for planned changes and as-found conditions that are not described and analyzed in existing safety analyses. The process evaluates changes and as-found conditions to determine whether revisions to the authorization basis must be reviewed and approved by DOE. There is an Unreviewed Safety Question (USQ) if a change introduces conditions not bounded by the facility authorization basis. When it is necessary to request DOE approval to revise the authorization basis, preparation of a System Safety Analysis (SSA) is recommended. This application guide describes the process of preparing an SSA and the desired contents of an SSA. Guidance is provided on how to identify items and practices which are important to safety; how to determine the credibility and significance of consequences of proposed accident scenarios; how to evaluate accident prevention and mitigation features of the planned change; and how to establish special requirements to ensure that a change can be implemented with adequate safety.

  10. Cost-Effectiveness Analysis of a Military Hearing Conservation Program.

    Science.gov (United States)

    Garcia, Seth L; Smith, Kenneth J; Palmer, Catherine

    2018-02-07

    Occupational noise threatens U.S. worker health and safety and commands a significant financial burden on state and federal government worker compensation programs. Previous studies suggest that hearing conservation programs have contributed to reduced occupational hearing loss for noise-exposed workers. Many military personnel are overexposed to noise and are provided hearing conservation services. Select military branches require all active duty personnel to follow hearing conservation program guidelines, regardless of individual noise exposure. We evaluated the cost-effectiveness of a military hearing conservation program, relative to no intervention, in relation to cases of hearing loss prevented. We employed cost-effectiveness analytic methods to compare the costs and effectiveness, in terms of hearing loss cases prevented, of a military hearing conservation program relative to no program. We used costs and probability estimates available in the literature and publicly available sources. The effectiveness of the interventions was analyzed based on whether hearing loss occurred over a 20-yr time frame. The incremental cost-effectiveness ratio of the hearing conservation program compared with no intervention was $10,657 per case of hearing loss prevented. Workers were 28% less likely to sustain hearing loss in our model when they received the hearing conservation program compared with no intervention, which reflected the greater effectiveness of the hearing conservation program. Cost-effectiveness results were sensitive to estimated values for the probability of acquiring hearing loss from both interventions and the cost of hearing protection. We performed a Monte Carlo probabilistic sensitivity analysis where we simultaneously varied all the model parameters to their extreme plausible bounds. When we ran 10,000 Monte Carlo iterations, we observed that the hearing conservation program was more cost-effective in 99% of cases when decision makers were willing to

  11. [Cost analysis of the colorectal neoplasm screen program in Beijing].

    Science.gov (United States)

    Mao, Ayan; Dong, Pei; Yan, Xiaoling; Hu, Guangyu; Chen, Qingkun; Qiu, Wuqi

    2015-05-01

    To conduct with a cost analysis of the colorectal neoplasm screening program in Beijing, and provide data evidence for decision making. Based on stratified cluster sampling method, we carried out a 2-stage colorectal neoplasm screening program within 6 districts, Dongcheng, Xicheng, Chaoyang, Haidian, Fengtai and Shijingshan, of Beijing city between October, 2012 to May. 2013. The first stage of the program was to conducting a cancer risk level evaluation for community residents who were forty years older and the second stage's task was to providing clinical exam for those high risk people who were selected from the first stage. There were about 12 953 residents were involved in this program. We calculated the main cost of the colorectal neoplasm screen program in Beijing. Then estimate the cost of detecting one Colorectal Neoplasm patient of this program and compare it with the total treatment cost for a patient. 2 487 high risk residents were selected by the first stage and 1 055 of them made appointment for the colonoscopy exam but only 375 accepted the exam, participate rate was 35.5%. 9 neoplasm cancer patients and 71 pre-cancer patient were found at the second stage, the detection rate were 69.2/100 000 and 546/100 000, respectively. The direct input for this neoplasm screening program was 227 100 CNY and the transport expense was 4 200 CNY in the calculations. The cost for detecting one cancer patient was about 19 900 CNY. Comparing with the total medical care cost of a cancer patient (1 282 800 CNY), especially for those have been diagnosed as middle to end stage cancer, the screening program (cost 842 800 CNY) might help to reduce the total health expenditure about 128 700 CNY, based on 12 953 local residents age above 40 years old. An colonoscopy based colorectal neoplasm screening program showed its function on medical expenditure saving and might have advantage on health social labor creating.

  12. Mondelēz Hope Kitchen Program, China: a Program Impact Pathways (PIP) analysis.

    Science.gov (United States)

    Li, Yanran; Yao, Xiaoxun; Gu, Lan

    2014-09-01

    Mondelēz Hope Kitchen is a community program initiated jointly in 2009 by Mondelēz International and the China Youth Development Foundation (CYDF). In response to the urgent needs of students, parents, and teachers at primary and middle schools in poverty-stricken rural areas of China, the program addresses the complex and intertwined issues of undernutrition and obesity. By funding both kitchen equipment and teacher training in health and nutrition, the Mondelēz Hope Kitchen Program improves the capacity of schools to supply healthy meals, helping students to access safe and nutritious foods and, ultimately, to improve their nutritional status and health. In 2011, the Mondelēz International Foundation awarded CYDF a grant to formally assess the impact of the original program design. The Mondelēz International Foundation encouraged CYDF and six other healthy lifestyles-focused community partners around the world to participate in this program evaluation workshop. The goals of this study were to describe the logic model of the Mondelēz Hope Kitchen Program, summarize a recent evaluation of the Mondelēz Hope Kitchen Program, and conduct a Program Impact Pathways (PIP) analysis to identify Critical Quality Control Points (CCPs) and a suite of impact indicators. The findings were presented at the Healthy Lifestyles Program Evaluation Workshop held in Granada, Spain, 13-14 September 2013, under the auspices of the Mondelēz International Foundation. The authors developed the program's PIP diagram based on deliberations involving the program managers and Director and consulting the "Hope Kitchen Management Rules "and "Hope Kitchen Inspection and Acceptance Report". The PIP analyses identified three CCPs: buy-in from schools, kitchen infrastructure, and changes in teachers' knowledge of nutrition after training. In addition, changes in children's knowledge of nutrition will be added to the core suite of impact evaluation indicators that also includes children

  13. Evaluating disease management program effectiveness: an introduction to survival analysis.

    Science.gov (United States)

    Linden, Ariel; Adams, John L; Roberts, Nancy

    2004-01-01

    Currently, the most widely used method in the disease management industry for evaluating program effectiveness is the "total population approach." This model is a pretest-posttest design, with the most basic limitation being that without a control group, there may be sources of bias and/or competing extraneous confounding factors that offer plausible rationale explaining the change from baseline. Survival analysis allows for the inclusion of data from censored cases, those subjects who either "survived" the program without experiencing the event (e.g., achievement of target clinical levels, hospitalization) or left the program prematurely, due to disenrollement from the health plan or program, or were lost to follow-up. Additionally, independent variables may be included in the model to help explain the variability in the outcome measure. In order to maximize the potential of this statistical method, validity of the model and research design must be assured. This paper reviews survival analysis as an alternative, and more appropriate, approach to evaluating DM program effectiveness than the current total population approach.

  14. GSLIB-style programs for discriminant analysis and regionalized classification

    Science.gov (United States)

    Bohling, G.C.

    1997-01-01

    Discriminant analysis is a statistical technique used to predict the group membership of a set of multivariate observations, each of which is assumed to arise from one of a set of distinct classes or groups. Each group is characterized by a certain distribution in multivariate space, and group allocations are based on the similarity of each sample to each group. Assuming multivariate normality, generalized distance measures based on the squared Mahalanobis distance from each sample to each group centroid arise as the natural measure of similarity. One can allocate samples to groups either on the basis of minimum generalized distance or, equivalently, maximum posterior probability of group membership. In earth science applications samples are often associated with geographic locations. In this situation regionalized classification can be used to produce a map representing group membership throughout the sampled domain. This can be accomplished by interpolating either generalized distances or membership probabilities from sample locations to regularly spaced grid nodes and comparing resulting grids to produce a classification map. This paper presents a set of GSLIB-style FORTRAN programs for performing discriminant analysis and regionalized classification. The program disco performs discriminant analysis and the programs xmd2cls and prb2cls combine interpolated distances and probabilities, respectively, to create a grid of predicted classifications. In addition, the utility program colbind allows the user to combine selected columns from different GSLIB-style data files into one file. ?? 1997 Elsevier Science Ltd.

  15. Paper de les proteïnes de fusió mitocondrial Opa1 i Mfn1 durant la diferenciació miogènica

    OpenAIRE

    Noguera Jordà, Eduard

    2014-01-01

    Les mitocòndries generen la major part de l'energia necessària per a la funció cel·lular mitjançant la respiració i la fosforilació oxidativa. Quan els mioblasts diferencien a miotubs, la biogènesi mitocondrial i l'activitat enzimàtica mitocondrial augmenta. A més, la regeneració muscular també està acompanyada d'un augment en l'activitat enzimàtica mitocondrial. I la dinàmica mitocondrial és essencial per mantenir les funcions bioenergètiques mitocondrials. Opa1 i la Mitofusina 1 (Mfn1) són ...

  16. Introduction de prestations de soins de santé mentale dans l'article 7 de l'OPAS: propositions et arguments

    OpenAIRE

    Francey, Sylvie

    2002-01-01

    L'article 7 de l'ordonnance sur les prestations dans l'assurance obligatoire des soins en cas de maladie (Ordonnance sur les prestations de l'assurance des soins, OPAS) a pour titre "Définition des soins" et il donne une liste de prestations à l'alinéa 2. Les prestations de santé mentale en terme de soins spécifiques, prodigués par des infirmières diplômées, en sont absentes ou à tout le moins incomplètes. Ceci n'est pas la conséquence d'une omission, mais plutôt dû au contexte d'il y a en...

  17. The Pattern of Retinal Ganglion Cell Loss in OPA1-Related Autosomal Dominant Optic Atrophy Inferred From Temporal, Spatial, and Chromatic Sensitivity Losses

    Science.gov (United States)

    Majander, Anna; João, Catarina; Rider, Andrew T.; Henning, G. Bruce; Votruba, Marcela; Moore, Anthony T.; Yu-Wai-Man, Patrick; Stockman, Andrew

    2017-01-01

    Purpose Progressive retinal ganglion cell (RGC) loss is the pathological hallmark of autosomal dominant optic atrophy (DOA) caused by pathogenic OPA1 mutations. The aim of this study was to conduct an in-depth psychophysical study of the visual losses in DOA and to infer any selective vulnerability of visual pathways subserved by different RGC subtypes. Methods We recruited 25 patients carrying pathogenic OPA1 mutations and age-matched healthy individuals. Spatial contrast sensitivity functions (SCSFs) and chromatic contrast sensitivity were quantified, the latter using the Cambridge Colour Test. In 11 patients, long (L) and short (S) wavelength–sensitive cone temporal acuities were measured as a function of target illuminance, and L-cone temporal contrast sensitivity (TCSF) as a function of temporal frequency. Results Spatial contrast sensitivity functions were abnormal, with the loss of sensitivity increasing with spatial frequency. Further, the highest L-cone temporal acuity fell on average by 10 Hz and the TCSFs by 0.66 log10 unit. Chromatic thresholds along the protan, deutan, and tritan axes were 8, 9, and 14 times higher than normal, respectively, with losses increasing with age and S-cone temporal acuity showing the most significant age-related decline. Conclusions Losses of midget parvocellular, parasol magnocellular, and bistratified koniocellular RGCs could account for the losses of high spatial frequency sensitivity and protan and deutan sensitivities, high temporal frequency sensitivity, and S-cone temporal and tritan sensitivities, respectively. The S-cone–related losses showed a significant deterioration with increasing patient age and could therefore prove useful biomarkers of disease progression in DOA. PMID:28125838

  18. LineVISAR. A fringe-trace data analysis program

    Energy Technology Data Exchange (ETDEWEB)

    Furnish, Michael D. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2014-02-01

    The line-imaging ORVIS or VISAR provides velocity as a function of position and time for a line on an experimental setup via a streak camera record of interference fringes. This document describes a Matlab-based program which guides the user through the process of converting these fringe data to a velocity surface. The data reduction is of the "fringe trace" type, wherein the changes in velocity at a given position on the line are calculated based on fringe motion past that point. The analyst must establish the fringe behavior up front, aided by peak-finding routines in the program. However, the later work of using fringe jumps to compensate for phase problems in other analysis techniques is greatly reduced. This program is not a standard GUI construction, and is prescriptive. At various points it saves the progress, allowing later restarts from those points.

  19. Using Runtime Analysis to Guide Model Checking of Java Programs

    Science.gov (United States)

    Havelund, Klaus; Norvig, Peter (Technical Monitor)

    2001-01-01

    This paper describes how two runtime analysis algorithms, an existing data race detection algorithm and a new deadlock detection algorithm, have been implemented to analyze Java programs. Runtime analysis is based on the idea of executing the program once. and observing the generated run to extract various kinds of information. This information can then be used to predict whether other different runs may violate some properties of interest, in addition of course to demonstrate whether the generated run itself violates such properties. These runtime analyses can be performed stand-alone to generate a set of warnings. It is furthermore demonstrated how these warnings can be used to guide a model checker, thereby reducing the search space. The described techniques have been implemented in the b e grown Java model checker called PathFinder.

  20. Data-flow Analysis of Programs with Associative Arrays

    Directory of Open Access Journals (Sweden)

    David Hauzar

    2014-05-01

    Full Text Available Dynamic programming languages, such as PHP, JavaScript, and Python, provide built-in data structures including associative arrays and objects with similar semantics—object properties can be created at run-time and accessed via arbitrary expressions. While a high level of security and safety of applications written in these languages can be of a particular importance (consider a web application storing sensitive data and providing its functionality worldwide, dynamic data structures pose significant challenges for data-flow analysis making traditional static verification methods both unsound and imprecise. In this paper, we propose a sound and precise approach for value and points-to analysis of programs with associative arrays-like data structures, upon which data-flow analyses can be built. We implemented our approach in a web-application domain—in an analyzer of PHP code.

  1. Social network analysis of public health programs to measure partnership.

    Science.gov (United States)

    Schoen, Martin W; Moreland-Russell, Sarah; Prewitt, Kim; Carothers, Bobbi J

    2014-12-01

    In order to prevent chronic diseases, community-based programs are encouraged to take an ecological approach to public health promotion and involve many diverse partners. Little is known about measuring partnership in implementing public health strategies. We collected data from 23 Missouri communities in early 2012 that received funding from three separate programs to prevent obesity and/or reduce tobacco use. While all of these funding programs encourage partnership, only the Social Innovation for Missouri (SIM) program included a focus on building community capacity and enhancing collaboration. Social network analysis techniques were used to understand contact and collaboration networks in community organizations. Measurements of average degree, density, degree centralization, and betweenness centralization were calculated for each network. Because of the various sizes of the networks, we conducted comparative analyses with and without adjustment for network size. SIM programs had increased measurements of average degree for partner collaboration and larger networks. When controlling for network size, SIM groups had higher measures of network density and lower measures of degree centralization and betweenness centralization. SIM collaboration networks were more dense and less centralized, indicating increased partnership. The methods described in this paper can be used to compare partnership in community networks of various sizes. Further research is necessary to define causal mechanisms of partnership development and their relationship to public health outcomes. Copyright © 2014 Elsevier Ltd. All rights reserved.

  2. Ready, Steady, Go! Program, Italy: a Program Impact Pathways (PIP) analysis.

    Science.gov (United States)

    Veracini, Giordana; Leonardi, Elisabetta; Girotti, Rita; Thrasher, Erika Willumsen

    2014-09-01

    Ready, Steady, Go! promotes proper nutrition and physical activity among people of all ages in targeted neighborhoods and encourages social integration and children's participation in decisions that affect their lives. It also seeks to involve parents in activities so that they can influence their children's attitudes toward lifestyles and personal development. This partnership has reached 70,000 Italian children and adults with new opportunities for physical activities and social experiences that help them improve nutritional behaviors while having fun with their peers. To assess the Ready, Steady, Go! Program logic and to identify Critical Quality Control Points (CCPs) and a core suite of impact indicators based on a Program Impact Pathways (PIP) analysis. The PIP analysis team reviewed the key activities and processes that form Ready, Steady, Go! and then identified key CCPs for the project. The findings were presented at the Healthy Lifestyles Program Evaluation Workshop held in Granada, Spain, 13-14 September 2013, under the auspices of the Mondelēz International Foundation. The PIP analysis confirmed that Ready, Steady, Go! has a structure that is likely to support the primary aims of the program. The CCPs identified are training of teachers in healthy lifestyles, teachers' active participation in the program, access to remodeled and well-equipped sports and recreational centers, participation of parents and grandparents, and involvement of local institutions and networks. A suite of impact indicators for changes in healthy lifestyle knowledge, attitudes, and behavior was identified. Project staff are now more aware of the importance of carefully monitoring the CCPs and have decided to conduct quarterly PIP-informed quality control evaluations.

  3. An Analysis of Test And Evaluation in Rapid Acquisition Programs

    Science.gov (United States)

    2015-12-01

    Outfits DT Developmental Testing DT&E Development Test and Evaluation DTC Developmental Test Command E3 Electromagnetic Environmental Effects...by the OEM and evaluated by the Communication-Electronics Command (CECOM) Safety Office and the former Developmental Test Command ( DTC ) covering all...Force Management School AMC Army Materiel Command AOA Analysis of Alternatives AOR Area of Operation APC Acquisition Program Candidates APG Aberdeen

  4. Dispersion analysis and linear error analysis capabilities of the space vehicle dynamics simulation program

    Science.gov (United States)

    Snow, L. S.; Kuhn, A. E.

    1975-01-01

    Previous error analyses conducted by the Guidance and Dynamics Branch of NASA have used the Guidance Analysis Program (GAP) as the trajectory simulation tool. Plans are made to conduct all future error analyses using the Space Vehicle Dynamics Simulation (SVDS) program. A study was conducted to compare the inertial measurement unit (IMU) error simulations of the two programs. Results of the GAP/SVDS comparison are presented and problem areas encountered while attempting to simulate IMU errors, vehicle performance uncertainties and environmental uncertainties using SVDS are defined. An evaluation of the SVDS linear error analysis capability is also included.

  5. Structural mode significance using INCA. [Interactive Controls Analysis computer program

    Science.gov (United States)

    Bauer, Frank H.; Downing, John P.; Thorpe, Christopher J.

    1990-01-01

    Structural finite element models are often too large to be used in the design and analysis of control systems. Model reduction techniques must be applied to reduce the structural model to manageable size. In the past, engineers either performed the model order reduction by hand or used distinct computer programs to retrieve the data, to perform the significance analysis and to reduce the order of the model. To expedite this process, the latest version of INCA has been expanded to include an interactive graphical structural mode significance and model order reduction capability.

  6. An Analysis of the Relationship Between the Professionalism of Defense Acquisition Program Managers and Program Outcomes

    Science.gov (United States)

    2011-11-30

    manager’s job: Folklore and fact . Harvard Business Review, 53(4), 49–61. Mohr, L. (1995). Impact analysis for social evaluation (2nd ed.). Thousand...and Mintzberg (1975) documented the attributes and competencies of effective managers. B. Fox’s Studies J. Ronald Fox’s two books (1974, 1988...significantly better than those of other components. In almost no cases, however, was this relationship evident. In fact , outcomes of Army programs

  7. Using alternative transient program and electromagnetic transients programs (ATP/EMTP in lightning overvoltages analysis

    Directory of Open Access Journals (Sweden)

    Mrvić Jovan

    2016-01-01

    Full Text Available The goal of this paper is to introduce a procedure for risk assessment of insulation failure due to storm surges. The simulations were carried out in ATP / EMTP software, which allowed the use of the Monte Carlo method for the statistical analysis of insulation coordination. The paper gives a detailed account of modelling of all the elements relevant to the analysis. At the same time, the capabilities of the programming language MODELS (allows the creation and implementation of new complex components within the ATP software are discussed.

  8. NASA Aeronautics Multidisciplinary Analysis and Design Fellowship Program

    Science.gov (United States)

    Grossman, B.; Gurdal, Z.; Kapania, R. K.; Mason, W. H.; Schetz, J. A.

    1999-01-01

    This program began as a grant from NASA Headquarters, NGT-10025, which was in effect from 10/l/93 until 10/31/96. The remaining funding for this effort was transferred from NASA Headquarters to NASA Langley and a new grant NGT-1-52155 was issued covering the period II/l/96 to 5/15/99. This report serves as the final report of NGT-1-52155. For a number of years, Virginia Tech had been on the forefront of research in the area of multidisciplinary analysis and design. In June of 1994, faculty members from aerospace and ocean engineering, engineering science and mechanics, mechanical engineering, industrial engineering, mathematics and computer sciences, at Virginia Tech joined together to form the Multidisciplinary Analysis and Design (MAD) Center for Advanced Vehicles. The center was established with the single goal: to perform research that is relevant to the needs of the US industry and to foster collaboration between the university, government and industry. In October of 1994, the center was chosen by NASA headquarters as one of the five university centers to establish a fellowship program to develop a graduate program in multidisciplinary analysis and design. The fellowship program provides full stipend and tuition support for seven U. S. students per year during their graduate studies. The grant is currently being administered by the NMO Branch of NASA Langley. To advise us regarding the problems faced by the industry, an industrial advisory board has been formed consisting of representatives from industry as well as government laboratories. The present membership includes major aerospace companies: Aurora Flight Sciences, Boeing: Philadelphia, Boeing: Long Beach, Boeing: Seattle, Boeing: St. Louis, Cessna, Ford, General Electric, Hughes, Lockheed-Martin: Palo Alto, Northrop-Grumman, Sikorsky, smaller, aerospace software companies: Aerosoft, Phoenix Integration and Proteus Engineering, along with representatives from government agencies, including: NASA Ames

  9. Control system design and analysis using the INteractive Controls Analysis (INCA) program

    Science.gov (United States)

    Bauer, Frank H.; Downing, John P.

    1987-01-01

    The INteractive Controls Analysis (INCA) program was developed at the Goddard Space Flight Center to provide a user friendly efficient environment for the design and analysis of linear control systems. Since its inception, INCA has found extensive use in the design, development, and analysis of control systems for spacecraft, instruments, robotics, and pointing systems. Moreover, the results of the analytic tools imbedded in INCA have been flight proven with at least three currently orbiting spacecraft. This paper describes the INCA program and illustrates, using a flight proven example, how the package can perform complex design analyses with relative ease.

  10. Proteomic analysis of fetal programming-related obesity markers.

    Science.gov (United States)

    Lee, Ji Hye; Yoo, Jae Young; You, Young-Ah; Kwon, Woo-Sung; Lee, Sang Mi; Pang, Myung-Geol; Kim, Young Ju

    2015-08-01

    The objectives of this study were to analyze fetal programming in rat brain using proteomic analysis and to identify fetal programming-related obesity markers. Sprague-Dawley rats were divided into four feeding groups: (i) the Ad Libitum (AdLib)/AdLib group was given a normal diet during pregnancy and the lactation period; (ii) the AdLib/maternal food restriction group (FR) was subjected to 50% FR during the lactation period; (iii) the FR/AdLib group was subjected to 50% FR during pregnancy; and (iv) the FR/FR group was subjected to 50% FR during pregnancy and the lactation period. Offspring from each group were sacrificed at 3 weeks of age and whole brains were dissected. To obtain a maximum number of protein markers related to obesity, 2DE and Pathway Studio bioinformatics analysis were performed. The identities of the markers among the selected and candidate proteins were confirmed by Western blotting and immunohistochemistry. Proteomic and bioinformatics analyses revealed that expression of ubiquitin carboxy-terminal hydrolase L1 (UCHL1) and Secernin 1 (SCRN1) were significantly different in the FR/AdLib group compared with the AdLib/AdLib group for both male and female offspring. These findings suggest that UCHL1 and SCRN1 may be used as fetal programming-related obesity markers. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  11. Energy Star Lighting Verification Program (Program for the Evaluation and Analysis of Residential Lighting)

    Energy Technology Data Exchange (ETDEWEB)

    Conan O' Rourke; Yutao Zhou

    2006-03-01

    The Program for the Evaluation and Analysis of Residential Lighting (PEARL) is a watchdog program. It was created in response to complaints received by utility program managers about the performance of certain Energy Star lighting products being promoted within their service territories and the lack of a self-policing mechanism within the lighting industry that would ensure the reliability of these products and their compliance with ENERGY STAR specifications. To remedy these problems, PEARL purchases and tests products that are available to the consumers in the marketplace. The Lighting Research Center (LRC) tests the selected products against the corresponding Energy Star specifications. This report includes the experimental procedure and data results of Cycle Three of PEARL program during the period of October 2002 to April 2003, along with the description of apparatus used, equipment calibration process, experimental methodology, and research findings from the testing. The products tested are 20 models of screw-based compact fluorescent lamps (CFL) of various types and various wattages made or marketed by 12 different manufacturers, and ten models of residential lighting fixtures from eight different manufacturers.

  12. Energy Star Lighting Verification Program (Program for the Evaluation and Analysis of Residential Lighting)

    Energy Technology Data Exchange (ETDEWEB)

    Conan O' Rourke; Yutao Zhou

    2006-03-01

    The Program for the Evaluation and Analysis of Residential Lighting (PEARL) is a watchdog program. It was created in response to complaints received by utility program managers about the performance of certain Energy Star lighting products being promoted within their service territories and the lack of a self-policing mechanism within the lighting industry that would ensure the reliability of these products and their compliance with ENERGY STAR specifications. To remedy these problems, PEARL purchases and tests products that are available to the consumers in the marketplace. The Lighting Research Center (LRC) tests the selected products against the corresponding Energy Star specifications. This report includes the experimental procedure and data results of Cycle Four and Cycle Five of PEARL program during the period of October 2003 to April 2004, along with the description of apparatus used, equipment calibration process, experimental methodology, and research findings from the testing. The parameter tested for Cycle Four is lumen maintenance at 40% rated life, and parameters tested for Cycle Five are all parameters required in Energy Star specifications except lumen maintenance at 40% rated life.

  13. Energy Star Lighting Verification Program (Program for the Evaluation and Analysis of Residential Lighting)

    Energy Technology Data Exchange (ETDEWEB)

    Conan O' Rourke; Yutao Zhou

    2006-03-01

    The Program for the Evaluation and Analysis of Residential Lighting (PEARL) is a watchdog program. It was created in response to complaints received by utility program managers about the performance of certain Energy Star lighting products being promoted within their service territories and the lack of a self-policing mechanism within the lighting industry that would ensure the reliability of these products and their compliance with ENERGY STAR specifications. To remedy these problems, PEARL purchases and tests products that are available to the consumers in the marketplace. The Lighting Research Center (LRC) tests the selected products against the corresponding Energy Star specifications. This report includes the experimental procedure and data results of Cycle Three and Cycle Four of PEARL program during the period of April 2003 to October 2003, along with the description of apparatus used, equipment calibration process, experimental methodology, and research findings from the testing. The parameter tested for Cycle three is lumen maintenance at 40% rated life, and parameters tested for Cycle Four are all parameters required in Energy Star specifications except lumen maintenance at 40% rated life.

  14. Aeroelastic analysis for propellers - mathematical formulations and program user's manual

    Science.gov (United States)

    Bielawa, R. L.; Johnson, S. A.; Chi, R. M.; Gangwani, S. T.

    1983-01-01

    Mathematical development is presented for a specialized propeller dedicated version of the G400 rotor aeroelastic analysis. The G400PROP analysis simulates aeroelastic characteristics particular to propellers such as structural sweep, aerodynamic sweep and high subsonic unsteady airloads (both stalled and unstalled). Formulations are presented for these expanded propeller related methodologies. Results of limited application of the analysis to realistic blade configurations and operating conditions which include stable and unstable stall flutter test conditions are given. Sections included for enhanced program user efficiency and expanded utilization include descriptions of: (1) the structuring of the G400PROP FORTRAN coding; (2) the required input data; and (3) the output results. General information to facilitate operation and improve efficiency is also provided.

  15. Dispersion analysis techniques within the space vehicle dynamics simulation program

    Science.gov (United States)

    Snow, L. S.; Kuhn, A. E.

    1975-01-01

    The Space Vehicle Dynamics Simulation (SVDS) program was evaluated as a dispersion analysis tool. The Linear Error Analysis (LEA) post processor was examined in detail and simulation techniques relative to conducting a dispersion analysis using the SVDS were considered. The LEA processor is a tool for correlating trajectory dispersion data developed by simulating 3 sigma uncertainties as single error source cases. The processor combines trajectory and performance deviations by a root-sum-square (RSS process) and develops a covariance matrix for the deviations. Results are used in dispersion analyses for the baseline reference and orbiter flight test missions. As a part of this study, LEA results were verified as follows: (A) Hand calculating the RSS data and the elements of the covariance matrix for comparison with the LEA processor computed data. (B) Comparing results with previous error analyses. The LEA comparisons and verification are made at main engine cutoff (MECO).

  16. Frequency Domain Computer Programs for Prediction and Analysis of Rail Vehicle Dynamics : Volume 2. Appendixes

    Science.gov (United States)

    1975-12-01

    Frequency domain computer programs developed or acquired by TSC for the analysis of rail vehicle dynamics are described in two volumes. Volume 2 contains program listings including subroutines for the four TSC frequency domain programs described in V...

  17. Students’ Needs Analysis in an EFL Program for University Professors

    Directory of Open Access Journals (Sweden)

    Paula Andrea Bedoya

    2015-10-01

    Full Text Available This study sets out to investigate professors’ needs from an English as a foreign language program in a public university regarding demands, interests, and lacks based on the methodology of needs analysis. Data collected through a survey, focus groups, and individual interviews showed that professors need to meet the institutional language policy for contractual and academic reasons. Additionally, data revealed their desire to learn English to communicate in both academic and non-academic settings. Moreover, the lack of time and effective learning strategies were reported as comprising the main constraints for learning. Finally, the authors present the strengths and weaknesses of the program as well as the participants’ suggestions for curriculum restructuring.

  18. Population genetics analysis using R and the Geneland program

    DEFF Research Database (Denmark)

    Guillot, Gilles; Santos, Filipe; Estoup, Arnaud

    2011-01-01

    Geneland program documentation 2011 Program distributed under GNU license as an R package on the Comprehensive R Archive Network.......Geneland program documentation 2011 Program distributed under GNU license as an R package on the Comprehensive R Archive Network....

  19. New Mexico district work-effort analysis computer program

    Science.gov (United States)

    Hiss, W.L.; Trantolo, A.P.; Sparks, J.L.

    1972-01-01

    The computer program (CAN 2) described in this report is one of several related programs used in the New Mexico District cost-analysis system. The work-effort information used in these programs is accumulated and entered to the nearest hour on forms completed by each employee. Tabulating cards are punched directly from these forms after visual examinations for errors are made. Reports containing detailed work-effort data itemized by employee within each project and account and by account and project for each employee are prepared for both current-month and year-to-date periods by the CAN 2 computer program. An option allowing preparation of reports for a specified 3-month period is provided. The total number of hours worked on each account and project and a grand total of hours worked in the New Mexico District is computed and presented in a summary report for each period. Work effort not chargeable directly to individual projects or accounts is considered as overhead and can be apportioned to the individual accounts and projects on the basis of the ratio of the total hours of work effort for the individual accounts or projects to the total New Mexico District work effort at the option of the user. The hours of work performed by a particular section, such as General Investigations or Surface Water, are prorated and charged to the projects or accounts within the particular section. A number of surveillance or buffer accounts are employed to account for the hours worked on special events or on those parts of large projects or accounts that require a more detailed analysis. Any part of the New Mexico District operation can be separated and analyzed in detail by establishing an appropriate buffer account. With the exception of statements associated with word size, the computer program is written in FORTRAN IV in a relatively low and standard language level to facilitate its use on different digital computers. The program has been run only on a Control Data Corporation

  20. Synfuel program analysis. Volume I. Procedures-capabilities

    Energy Technology Data Exchange (ETDEWEB)

    Muddiman, J. B.; Whelan, J. W.

    1980-07-01

    This is the first of the two volumes describing the analytic procedures and resulting capabilities developed by Resource Applications (RA) for examining the economic viability, public costs, and national benefits of alternative synfuel projects and integrated programs. This volume is intended for Department of Energy (DOE) and Synthetic Fuel Corporation (SFC) program management personnel and includes a general description of the costing, venture, and portfolio models with enough detail for the reader to be able to specifiy cases and interpret outputs. It also contains an explicit description (with examples) of the types of results which can be obtained when applied to: the analysis of individual projects; the analysis of input uncertainty, i.e., risk; and the analysis of portfolios of such projects, including varying technology mixes and buildup schedules. In all cases, the objective is to obtain, on the one hand, comparative measures of private investment requirements and expected returns (under differing public policies) as they affect the private decision to proceed, and, on the other, public costs and national benefits as they affect public decisions to participate (in what form, in what areas, and to what extent).

  1. GAP ANALYSIS PROGRAM GIZI DAN KESEHATAN DI POSYANDU KABUPATEN BOGOR

    Directory of Open Access Journals (Sweden)

    Ellis Endang Nikmawati

    2012-03-01

    Full Text Available 800x600 Normal 0 false false false IN X-NONE X-NONE MicrosoftInternetExplorer4 Revitalization of Integrated Service Center Post (Posyandu is successful when  focused to its main function as community institution services. Determine gap analysis program based on tangibles, reliability, responsiveness, assurance, empathy dimension. Exploratory and experimental designs was applied in this study, which was conducted at Darmaga and Ciomas district, Bogor Regency from March to August 2008. The data included primary and secondary data. The respondent in the experiment was 240 mothers of children under five years and 80 cadres. Gap analysis was used to know the expected and the real nutrition and health program of respondent. Totally 96 balita’s mother, pregnancy and reproductive women and 16 cadres were involved in this study. The average of gap realization with standard tool -0,75; Tangibles dimension -0,35; Reliability -0,10; Responsiveness -0,37; Assurance  -0,44, and Empathy -0,47, its mean that a tools accomplisment only 25% (less; tangible dimension 65% (enough; reliability 90% (good; responsiveness dimension 63% (enough; assurance dimension  56% (less and emphaty 53%  (less, respectively.   Key words:  posyandu performance,  nutrition education, gap analysis

  2. Polyglot programming in applications used for genetic data analysis.

    Science.gov (United States)

    Nowak, Robert M

    2014-01-01

    Applications used for the analysis of genetic data process large volumes of data with complex algorithms. High performance, flexibility, and a user interface with a web browser are required by these solutions, which can be achieved by using multiple programming languages. In this study, I developed a freely available framework for building software to analyze genetic data, which uses C++, Python, JavaScript, and several libraries. This system was used to build a number of genetic data processing applications and it reduced the time and costs of development.

  3. The Efficacy of Machine Learning Programs for Navy Manpower Analysis

    Science.gov (United States)

    1993-03-01

    Machine Learning Programs for Navy Manpower Analysis 12 Personal Author(s) Dennis E. Pytel, Jr. 13a Type of Report 13b Time Covered 14 Date of Report...NPJT C-* -OUBLE- Source:AI IAker1 Meul p. 2-14 Figure 1: Four Input, Three Layer Polynomial Network. AIM uses seven types of nodes. The algebraic form of...I II iii short dark. blue: - tall red. bhe: + taN L d ak, blue: - 4 b w tall duot brown: - sh"d, blond, blue: + tol blod , br• n: - tall. bland. blue

  4. Knowledge transfer in pair programming: An in-depth analysis

    DEFF Research Database (Denmark)

    Plonka, Laura; Sharp, Helen; van der Linden, Janet

    2015-01-01

    constellations. We ask “what does it take to be a good “expert” and how can a “novice” best learn from a more experienced developer?”. An in-depth investigation of video and audio excerpts of professional pair programming sessions using Interaction Analysis reveals: six teaching strategies, ranging from “giving...... influences the strategies, challenges and benefits, in particular the roles of driver and navigator and agile prioritisation which considers business value rather than educational progression. Utilising these strategies more widely and recognizing the challenges and benefits for both partners will help...

  5. User's operating procedures. Volume 2: Scout project financial analysis program

    Science.gov (United States)

    Harris, C. G.; Haris, D. K.

    1985-01-01

    A review is presented of the user's operating procedures for the Scout Project Automatic Data system, called SPADS. SPADS is the result of the past seven years of software development on a Prime mini-computer located at the Scout Project Office, NASA Langley Research Center, Hampton, Virginia. SPADS was developed as a single entry, multiple cross-reference data management and information retrieval system for the automation of Project office tasks, including engineering, financial, managerial, and clerical support. This volume, two (2) of three (3), provides the instructions to operate the Scout Project Financial Analysis program in data retrieval and file maintenance via the user friendly menu drivers.

  6. Hybrid Information Flow Analysis for Programs with Arrays

    Directory of Open Access Journals (Sweden)

    Gergö Barany

    2016-07-01

    Full Text Available Information flow analysis checks whether certain pieces of (confidential data may affect the results of computations in unwanted ways and thus leak information. Dynamic information flow analysis adds instrumentation code to the target software to track flows at run time and raise alarms if a flow policy is violated; hybrid analyses combine this with preliminary static analysis. Using a subset of C as the target language, we extend previous work on hybrid information flow analysis that handled pointers to scalars. Our extended formulation handles arrays, pointers to array elements, and pointer arithmetic. Information flow through arrays of pointers is tracked precisely while arrays of non-pointer types are summarized efficiently. A prototype of our approach is implemented using the Frama-C program analysis and transformation framework. Work on a full machine-checked proof of the correctness of our approach using Isabelle/HOL is well underway; we present the existing parts and sketch the rest of the correctness argument.

  7. Integrated Data Collection Analysis (IDCA) Program — Ammonium Nitrate

    Energy Technology Data Exchange (ETDEWEB)

    Sandstrom, Mary M. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Brown, Geoffrey W. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Preston, Daniel N. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Pollard, Colin J. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Warner, Kirstin F. [Naval Surface Warfare Center (NSWC), Indian Head, MD (United States). Indian Head Division; Sorensen, Daniel N. [Naval Surface Warfare Center (NSWC), Indian Head, MD (United States). Indian Head Division; Remmers, Daniel L. [Naval Surface Warfare Center (NSWC), Indian Head, MD (United States). Indian Head Division; Phillips, Jason J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Shelley, Timothy J. [Bureau of Alcohol, Tobacco and Firearms, Redstone Arsenal, AL (United States); Reyes, Jose A. [Applied Research Associates, Tyndall AFB, FL (United States); Hsu, Peter C. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Reynolds, John G. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2013-05-17

    The Integrated Data Collection Analysis (IDCA) program is conducting a proficiency study for Small- Scale Safety and Thermal (SSST) testing of homemade explosives (HMEs). Described here are the results for impact, friction, electrostatic discharge, and differential scanning calorimetry analysis of ammonium nitrate (AN). AN was tested, in most cases, as both received from manufacturer and dried/sieved. The participants found the AN to be: 1) insensitive in Type 12A impact testing (although with a wide range of values), 2) completely insensitive in BAM friction testing, 3) less sensitive than the RDX standard in ABL friction testing, 4) less sensitive than RDX in ABL ESD testing, and 5) less sensitive than RDX and PETN in DSC thermal analyses.

  8. Integrated Data Analysis (IDCA) Program - PETN Class 4 Standard

    Energy Technology Data Exchange (ETDEWEB)

    Sandstrom, Mary M. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Brown, Geoffrey W. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Preston, Daniel N. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Pollard, Colin J. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Warner, Kirstin F. [Naval Surface Warfare Center (NSWC), Indian Head, MD (United States). Indian Head Division; Sorensen, Daniel N. [Naval Surface Warfare Center (NSWC), Indian Head, MD (United States). Indian Head Division; Remmers, Daniel L. [Naval Surface Warfare Center (NSWC), Indian Head, MD (United States). Indian Head Division; Shelley, Timothy J. [Air Force Research Lab. (AFRL), Tyndall AFB, FL (United States); Reyes, Jose A. [Applied Research Associates, Tyndall AFB, FL (United States); Phillips, Jason J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Hsu, Peter C. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Reynolds, John G. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2012-08-01

    The Integrated Data Collection Analysis (IDCA) program is conducting a proficiency study for Small- Scale Safety and Thermal (SSST) testing of homemade explosives (HMEs). Described here are the results for impact, friction, electrostatic discharge, and differential scanning calorimetry analysis of PETN Class 4. The PETN was found to have: 1) an impact sensitivity (DH50) range of 6 to 12 cm, 2) a BAM friction sensitivity (F50) range 7 to 11 kg, TIL (0/10) of 3.7 to 7.2 kg, 3) a ABL friction sensitivity threshold of 5 or less psig at 8 fps, 4) an ABL ESD sensitivity threshold of 0.031 to 0.326 j/g, and 5) a thermal sensitivity of an endothermic feature with Tmin = ~ 141 °C, and a exothermic feature with a Tmax = ~205°C.

  9. An algebraic approach to analysis of recursive and concurrent programs

    DEFF Research Database (Denmark)

    Terepeta, Michal Tomasz

    This thesis focuses on formal techniques based on static program analysis, model checking and abstract interpretation that offer means for reasoning about software, verification of its properties and discovering potential bugs. First, we investigate an algebraic approach to static analysis...... the soundness or completeness results. Moreover, we present a new application of pushdown systems in the context of an aspect-oriented process calculus. The addition of aspect-oriented features makes it possible for a process to exhibit a recursive structure. We show how one can faithfully model and analyze...... such a language. We also introduce an abstract domain that symbolically represents the messages sent between the concurrently executing processes. It stores prefixes or suffixes of communication traces including various constraints imposed on the messages. Since the problem has exponential complexity, we also...

  10. Ca analysis: an Excel based program for the analysis of intracellular calcium transients including multiple, simultaneous regression analysis.

    Science.gov (United States)

    Greensmith, David J

    2014-01-01

    Here I present an Excel based program for the analysis of intracellular Ca transients recorded using fluorescent indicators. The program can perform all the necessary steps which convert recorded raw voltage changes into meaningful physiological information. The program performs two fundamental processes. (1) It can prepare the raw signal by several methods. (2) It can then be used to analyze the prepared data to provide information such as absolute intracellular Ca levels. Also, the rates of change of Ca can be measured using multiple, simultaneous regression analysis. I demonstrate that this program performs equally well as commercially available software, but has numerous advantages, namely creating a simplified, self-contained analysis workflow. Copyright © 2013 The Author. Published by Elsevier Ireland Ltd.. All rights reserved.

  11. Integrated Data Collection Analysis (IDCA) Program - SSST Testing Methods

    Energy Technology Data Exchange (ETDEWEB)

    Sandstrom, Mary M. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Brown, Geoffrey W. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Preston, Daniel N. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Pollard, Colin J. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Warner, Kirstin F. [Naval Surface Warfare Center (NSWC), Indian Head, MD (United States). Indian Head Division; Remmers, Daniel L. [Naval Surface Warfare Center (NSWC), Indian Head, MD (United States). Indian Head Division; Sorensen, Daniel N. [Naval Surface Warfare Center (NSWC), Indian Head, MD (United States). Indian Head Division; Whinnery, LeRoy L. [Sandia National Lab. (SNL-CA), Livermore, CA (United States); Phillips, Jason J. [Sandia National Lab. (SNL-CA), Livermore, CA (United States); Shelley, Timothy J. [Bureau of Alcohol, Tobacco and Firearms (ATF), Huntsville, AL (United States); Reyes, Jose A. [Applied Research Associates, Tyndall AFB, FL (United States); Hsu, Peter C. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Reynolds, John G. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2013-03-25

    The Integrated Data Collection Analysis (IDCA) program is conducting a proficiency study for Small- Scale Safety and Thermal (SSST) testing of homemade explosives (HMEs). Described here are the methods used for impact, friction, electrostatic discharge, and differential scanning calorimetry analysis during the IDCA program. These methods changed throughout the Proficiency Test and the reasons for these changes are documented in this report. The most significant modifications in standard testing methods are: 1) including one specified sandpaper in impact testing among all the participants, 2) diversifying liquid test methods for selected participants, and 3) including sealed sample holders for thermal testing by at least one participant. This effort, funded by the Department of Homeland Security (DHS), is putting the issues of safe handling of these materials in perspective with standard military explosives. The study is adding SSST testing results for a broad suite of different HMEs to the literature. Ultimately the study will suggest new guidelines and methods and possibly establish the SSST testing accuracies needed to develop safe handling practices for HMEs. Each participating testing laboratory uses identical test materials and preparation methods wherever possible. The testing performers involved are Lawrence Livermore National Laboratory (LLNL), Los Alamos National Laboratory (LANL), Indian Head Division, Naval Surface Warfare Center, (NSWC IHD), Sandia National Laboratories (SNL), and Air Force Research Laboratory (AFRL/RXQL). These tests are conducted as a proficiency study in order to establish some consistency in test protocols, procedures, and experiments and to compare results when these testing variables cannot be made consistent.

  12. Establishment of a human DOA 'plus' iPSC line, IISHDOi003-A, with the mutation in the OPA1 gene: c.1635C>A; p.Ser545Arg.

    Science.gov (United States)

    Zurita-Díaz, Francisco; Galera-Monge, Teresa; Moreno-Izquierdo, Ana; Corton, Marta; Ayuso, Carmen; Garesse, Rafael; Gallardo, M Esther

    2017-10-01

    We have generated a human iPSC line IISHDOi003-A from fibroblasts of a patient with a dominant optic atrophy 'plus' phenotype, harbouring a heterozygous mutation, c.1635C>A; p.Ser545Arg, in the OPA1 gene. Reprogramming factors Oct3/4, Sox2, Klf4, and c-Myc were delivered using Sendai virus. Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

  13. Performance Demonstration Program Plan for Analysis of Simulated Headspace Gases

    Energy Technology Data Exchange (ETDEWEB)

    Carlsbad Field Office

    2006-04-01

    The Performance Demonstration Program (PDP) for headspace gases distributes sample gases of volatile organic compounds (VOCs) for analysis. Participating measurement facilities (i.e., fixed laboratories, mobile analysis systems, and on-line analytical systems) are located across the United States. Each sample distribution is termed a PDP cycle. These evaluation cycles provide an objective measure of the reliability of measurements performed for transuranic (TRU) waste characterization. The primary documents governing the conduct of the PDP are the Quality Assurance Program Document (QAPD) (DOE/CBFO-94-1012) and the Waste Isolation Pilot Plant (WIPP) Waste Analysis Plan (WAP) contained in the Hazardous Waste Facility Permit (NM4890139088-TSDF) issued by the New Mexico Environment Department (NMED). The WAP requires participation in the PDP; the PDP must comply with the QAPD and the WAP. This plan implements the general requirements of the QAPD and the applicable requirements of the WAP for the Headspace Gas (HSG) PDP. Participating measurement facilities analyze blind audit samples of simulated TRU waste package headspace gases according to the criteria set by this PDP Plan. Blind audit samples (hereafter referred to as PDP samples) are used as an independent means to assess each measurement facility’s compliance with the WAP quality assurance objectives (QAOs). To the extent possible, the concentrations of VOC analytes in the PDP samples encompass the range of concentrations anticipated in actual TRU waste package headspace gas samples. Analyses of headspace gases are required by the WIPP to demonstrate compliance with regulatory requirements. These analyses must be performed by measurement facilities that have demonstrated acceptable performance in this PDP. These analyses are referred to as WIPP analyses and the TRU waste package headspace gas samples on which they are performed are referred to as WIPP samples in this document. Participating measurement

  14. Performance Demonstration Program Plan for Analysis of Simulated Headspace Gases

    Energy Technology Data Exchange (ETDEWEB)

    Carlsbad Field Office

    2007-11-13

    The Performance Demonstration Program (PDP) for headspace gases distributes blind audit samples in a gas matrix for analysis of volatile organic compounds (VOCs). Participating measurement facilities (i.e., fixed laboratories, mobile analysis systems, and on-line analytical systems) are located across the United States. Each sample distribution is termed a PDP cycle. These evaluation cycles provide an objective measure of the reliability of measurements performed for transuranic (TRU) waste characterization. The primary documents governing the conduct of the PDP are the Quality Assurance Program Document (QAPD) (DOE/CBFO-94-1012) and the Waste Isolation Pilot Plant (WIPP) Waste Analysis Plan (WAP) contained in the Hazardous Waste Facility Permit (NM4890139088-TSDF) issued by the New Mexico Environment Department (NMED). The WAP requires participation in the PDP; the PDP must comply with the QAPD and the WAP. This plan implements the general requirements of the QAPD and the applicable requirements of the WAP for the Headspace Gas (HSG) PDP. Participating measurement facilities analyze blind audit samples of simulated TRU waste package headspace gases according to the criteria set by this PDP Plan. Blind audit samples (hereafter referred to as PDP samples) are used as an independent means to assess each measurement facility’s compliance with the WAP quality assurance objectives (QAOs). To the extent possible, the concentrations of VOC analytes in the PDP samples encompass the range of concentrations anticipated in actual TRU waste package headspace gas samples. Analyses of headspace gases are required by the WIPP to demonstrate compliance with regulatory requirements. These analyses must be performed by measurement facilities that have demonstrated acceptable performance in this PDP. These analyses are referred to as WIPP analyses and the TRU waste package headspace gas samples on which they are performed are referred to as WIPP samples in this document

  15. Performance Demonstration Program Plan for Analysis of Simulated Headspace Gases

    Energy Technology Data Exchange (ETDEWEB)

    Carlsbad Field Office

    2007-11-19

    The Performance Demonstration Program (PDP) for headspace gases distributes blind audit samples in a gas matrix for analysis of volatile organic compounds (VOCs). Participating measurement facilities (i.e., fixed laboratories, mobile analysis systems, and on-line analytical systems) are located across the United States. Each sample distribution is termed a PDP cycle. These evaluation cycles provide an objective measure of the reliability of measurements performed for transuranic (TRU) waste characterization. The primary documents governing the conduct of the PDP are the Quality Assurance Program Document (QAPD) (DOE/CBFO-94-1012) and the Waste Isolation Pilot Plant (WIPP) Waste Analysis Plan (WAP) contained in the Hazardous Waste Facility Permit (NM4890139088-TSDF) issued by the New Mexico Environment Department (NMED). The WAP requires participation in the PDP; the PDP must comply with the QAPD and the WAP. This plan implements the general requirements of the QAPD and the applicable requirements of the WAP for the Headspace Gas (HSG) PDP. Participating measurement facilities analyze blind audit samples of simulated TRU waste package headspace gases according to the criteria set by this PDP Plan. Blind audit samples (hereafter referred to as PDP samples) are used as an independent means to assess each measurement facility’s compliance with the WAP quality assurance objectives (QAOs). To the extent possible, the concentrations of VOC analytes in the PDP samples encompass the range of concentrations anticipated in actual TRU waste package headspace gas samples. Analyses of headspace gases are required by the WIPP to demonstrate compliance with regulatory requirements. These analyses must be performed by measurement facilities that have demonstrated acceptable performance in this PDP. These analyses are referred to as WIPP analyses and the TRU waste package headspace gas samples on which they are performed are referred to as WIPP samples in this document

  16. Characterisation of heat-induced protein aggregation in whey protein isolate and the influence of aggregation on the availability of amino groups as measured by the ortho-phthaldialdehyde (OPA) and trinitrobenzenesulfonic acid (TNBS) methods.

    Science.gov (United States)

    Mulcahy, Eve M; Fargier-Lagrange, Maéva; Mulvihill, Daniel M; O'Mahony, James A

    2017-08-15

    Whey protein isolate (WPI) solutions, with different levels of aggregated protein, were prepared by heating (5% protein, pH 7, 90°C for 30min) WPI solutions with either 20mM added NaCl (WPI+NaCl), 5mM N-ethylmaleimide (WPI+NEM) or 20mM added NaCl and 5mM NEM (WPI+NaCl+NEM). Gel electrophoresis demonstrated that the heated WPI and WPI+NaCl solutions had higher levels of aggregated protein, due to more covalent interactions between proteins, than the heated WPI+NEM and WPI+NaCl+NEM solutions. There were marked differences in the levels of amino groups between all heated WPI solutions when measured by the OPA and TNBS methods, with lower levels being measured by the TNBS method than by the OPA method. These results demonstrate that the measurement of available amino groups by the OPA method is less impacted than by the TNBS method after heat-induced structural changes, arising from disulfide or sulfhydryl-disulfide bond-mediated aggregation of whey protein molecules. Copyright © 2017 Elsevier Ltd. All rights reserved.

  17. Accident Sequence Evaluation Program: Human reliability analysis procedure

    Energy Technology Data Exchange (ETDEWEB)

    Swain, A.D.

    1987-02-01

    This document presents a shortened version of the procedure, models, and data for human reliability analysis (HRA) which are presented in the Handbook of Human Reliability Analysis With emphasis on Nuclear Power Plant Applications (NUREG/CR-1278, August 1983). This shortened version was prepared and tried out as part of the Accident Sequence Evaluation Program (ASEP) funded by the US Nuclear Regulatory Commission and managed by Sandia National Laboratories. The intent of this new HRA procedure, called the ''ASEP HRA Procedure,'' is to enable systems analysts, with minimal support from experts in human reliability analysis, to make estimates of human error probabilities and other human performance characteristics which are sufficiently accurate for many probabilistic risk assessments. The ASEP HRA Procedure consists of a Pre-Accident Screening HRA, a Pre-Accident Nominal HRA, a Post-Accident Screening HRA, and a Post-Accident Nominal HRA. The procedure in this document includes changes made after tryout and evaluation of the procedure in four nuclear power plants by four different systems analysts and related personnel, including human reliability specialists. The changes consist of some additional explanatory material (including examples), and more detailed definitions of some of the terms. 42 refs.

  18. The NASA aircraft noise prediction program improved propeller analysis system

    Science.gov (United States)

    Nguyen, L. Cathy

    1991-09-01

    The improvements and the modifications of the NASA Aircraft Noise Prediction Program (ANOPP) and the Propeller Analysis System (PAS) are described. Comparisons of the predictions and the test data are included in the case studies for the flat plate model in the Boundary Layer Module, for the effects of applying compressibility corrections to the lift and pressure coefficients, for the use of different weight factors in the Propeller Performance Module, for the use of the improved retarded time equation solution, and for the effect of the number grids in the Transonic Propeller Noise Module. The DNW tunnel test data of a propeller at different angles of attack and the Dowty Rotol data are compared with ANOPP predictions. The effect of the number of grids on the Transonic Propeller Noise Module predictions and the comparison of ANOPP TPN and DFP-ATP codes are studied. In addition to the above impact studies, the transonic propeller noise predictions for the SR-7, the UDF front rotor, and the support of the enroute noise test program are included.

  19. Components of Program for Analysis of Spectra and Their Testing

    Directory of Open Access Journals (Sweden)

    Ivan Taufer

    2013-11-01

    Full Text Available The spectral analysis of aqueous solutions of multi-component mixtures is used for identification and distinguishing of individual componentsin the mixture and subsequent determination of protonation constants and absorptivities of differently protonated particles in the solution in steadystate (Meloun and Havel 1985, (Leggett 1985. Apart from that also determined are the distribution diagrams, i.e. concentration proportions ofthe individual components at different pH values. The spectra are measured with various concentrations of the basic components (one or severalpolyvalent weak acids or bases and various pH values within the chosen range of wavelengths. The obtained absorbance response area has to beanalyzed by non-linear regression using specialized algorithms. These algorithms have to meet certain requirements concerning the possibility ofcalculations and the level of outputs. A typical example is the SQUAD(84 program, which was gradually modified and extended, see, e.g., (Melounet al. 1986, (Meloun et al. 2012.

  20. ENGINEERING ECONOMIC ANALYSIS OF A PROGRAM FOR ARTIFICIAL GROUNDWATER RECHARGE.

    Science.gov (United States)

    Reichard, Eric G.; Bredehoeft, John D.

    1984-01-01

    This study describes and demonstrates two alternate methods for evaluating the relative costs and benefits of artificial groundwater recharge using percolation ponds. The first analysis considers the benefits to be the reduction of pumping lifts and land subsidence; the second considers benefits as the alternative costs of a comparable surface delivery system. Example computations are carried out for an existing artificial recharge program in Santa Clara Valley in California. A computer groundwater model is used to estimate both the average long term and the drought period effects of artificial recharge in the study area. Results indicate that the costs of artificial recharge are considerably smaller than the alternative costs of an equivalent surface system. Refs.

  1. Cost-Utility Analysis of a Cardiac Telerehabilitation Program

    DEFF Research Database (Denmark)

    Kidholm, Kristian; Rasmussen, Maja Kjær; Andreasen, Jan Jesper

    2016-01-01

    and Methods: The analysis was carried out together with a randomized controlled trial with 151 patients during 2012-2014. Costs of the intervention were estimated with a health sector perspective following international guidelines for CU. Quality of life was assessed using the 36-Item Short Form Health Survey......Background: Cardiac rehabilitation can reduce mortality of patients with cardiovascular disease, but a frequently low participation rate in rehabilitation programs has been found globally. The objective of the Teledialog study was to assess the cost-utility (CU) of a cardiac telerehabilitation (CTR....... Results: The rehabilitation activities were approximately the same in the two groups, but the number of contacts with the physiotherapist was higher among the intervention group. The mean total cost per patient was (sic)1,700 higher in the intervention group. The quality-adjusted life-years (QALYs) gain...

  2. Product-Related Programming and Children's TV: A Content Analysis.

    Science.gov (United States)

    Eaton, B. Carol; Dominick, Joseph R.

    1991-01-01

    Analyzes the content of 16 hours of children's cartoon television programs. Finds that (1) all programs contained some violence, but especially those programs linked with toy merchandisers; (2) such programs used more theme music; and (3) few Black characters were shown, whereas males predominated and females were victims more often than were men.…

  3. The Military Construction (MILCON) Program and Privatization: A Comparative Analysis

    Science.gov (United States)

    1990-09-01

    8287, Shared Energy Savings Programs 3 - 10 U.S.C. 2394, Energy Production Facilities Program 4 - 10 U.S.C. 2667, Real Property Outleasing 5 - 10...of Long-Term Facility Contracts 3 - 42 U.S.C. 8287, Shared Energy Savings Programs 4 - 10 U.S.C. 2394, Energy Production Facilities Program 5 - 10

  4. Development of synthetic analysis program concerning on the safety of energy resources

    Energy Technology Data Exchange (ETDEWEB)

    Chang, S. H.; Choi, S. S.; Cheong, Y. H.; Ahn, S. H.; Chang, W. J. [Atomic Creative Technology, Daejeon (Korea, Republic of)

    2007-03-15

    Methodology development of synthetic analysis of energy resources: build system methodology of synthetic analysis of energy resources. Development of web-based enquete program, develop web-based enquete program to support synthetic analysis of energy resources. Aggregation Software development, develop AHP algorithm and aggregation software for the synthetic analysis of energy resources.

  5. Exercise portrayal in children’s television programs: analysis of the UK and Irish programming

    Directory of Open Access Journals (Sweden)

    Scully P

    2016-09-01

    Full Text Available Paul Scully,1 Orlaith Reid,1 Alan P Macken,1–3 Mark Healy,4 Jean Saunders,4 Des Leddin,3,5 Walter Cullen,3 Colum P Dunne,3 Clodagh S O’Gorman1–3,5 1The Children’s Ark, University Hospital Limerick, Limerick, 2National Children’s Research Centre, Dublin, 3Centre for Interventions in Infection, Inflammation & Immunity (4i, Graduate Entry Medical School, 4C-Star, University of Limerick, Limerick, Ireland; 5Department of Medicine, Dalhousie University, Halifax, Canada Background: Television watching is obesogenic due to its sedentary nature and programming content, which influences children. Few studies have examined exercise placement within children-specific programming. This study aimed to investigate the frequency and type of exercise placement in children-specific television broadcasts and to compare placements on the UK and Irish television channels.Methods: Content analysis for five weekdays’ worth of children-specific television broadcasting totaling 82.5 hours on both the UK (British Broadcasting Corporation and Irish (Radió Teilifís Éireann television channels was performed. For the purposes of comparing the UK and Irish placements, analysis was restricted to programming broadcast between 6 am and 11.30 am. Exercise placements were coded based on type of activity, activity context, activity motivating factors and outcome, and characters involved.Results: A total of 780 cues were recorded during the total recording period. A wide variety of sports were depicted, but dancing-related cues were most commonly seen (n=163, 23.3%, with the majority of cues being of mild (n=365, 65.9% or moderate (n=172, 31.0% intensity. The majority of cues were associated with a positive outcome (n=404, 61.4%, and social motivations were most commonly seen (n=289, 30.3%. The Irish and the UK portrayals were broadly similar.Conclusion: This study highlights the wide variety of sports portrayed and the active effort undertaken by television

  6. Regression Computer Programs for Setwise Regression and Three Related Analysis of Variance Techniques.

    Science.gov (United States)

    Williams, John D.; Lindem, Alfred C.

    Four computer programs using the general purpose multiple linear regression program have been developed. Setwise regression analysis is a stepwise procedure for sets of variables; there will be as many steps as there are sets. Covarmlt allows a solution to the analysis of covariance design with multiple covariates. A third program has three…

  7. On Static and Dynamic Control-Flow Information in Program Analysis and Transformation

    DEFF Research Database (Denmark)

    Damian, Daniel

    This thesis addresses several aspects of static and dynamic control-flow information in programming languages, by investigating its interaction with program transformation and program analysis. Control-flow information indicates for each point in a program the possible program points to be executed...... that a non-duplicating CPS transformation does not alter the result of a monovariant constraint-based control-flow analysis. Building on control-flow analysis, we show that traditional constraint-based binding-time analysis and traditional partial evaluation benefit from the effects of a CPS transformation...

  8. [A SAS marco program for batch processing of univariate Cox regression analysis for great database].

    Science.gov (United States)

    Yang, Rendong; Xiong, Jie; Peng, Yangqin; Peng, Xiaoning; Zeng, Xiaomin

    2015-02-01

    To realize batch processing of univariate Cox regression analysis for great database by SAS marco program. We wrote a SAS macro program, which can filter, integrate, and export P values to Excel by SAS9.2. The program was used for screening survival correlated RNA molecules of ovarian cancer. A SAS marco program could finish the batch processing of univariate Cox regression analysis, the selection and export of the results. The SAS macro program has potential applications in reducing the workload of statistical analysis and providing a basis for batch processing of univariate Cox regression analysis.

  9. WHB/WTB SPACE PROGRAM ANALYSIS FOR SITE RECOMMENDATION

    Energy Technology Data Exchange (ETDEWEB)

    W.D. Lindholm

    2000-05-25

    The purpose of this analysis is to identify and evaluate the functional space and spatial relationship requirements for the two main nuclear buildings, the Waste Handling Building (WHB) and the Waste Treatment Building (WTB), which are part of the Repository Surface Facilities. This analysis is consistent with the Development Plan for ''WHB/WTB Space Program Analysis for Site Recommendation'' (CRWMS M&O 2000r), which concentrates on the primary, primary support, facility support, and miscellaneous building support areas located in the WHB and WTB. The development plan was completed in accordance with AP-2.134, ''Technical Product Development Planning''. The objective and scope of this analysis is to develop a set of spatial parameters (e.g., square footage, room heights, etc.) and layout requirements (e.g., adjacency and access/circulation requirements, etc.) from which preliminary building floor plans are developed and presented as figures. The resulting figures will provide information to support the Site Recommendation and the total system life cycle cost. This analysis uses the Viability Assessment (VA) ''Surface Nuclear Facilities Space Program Analysis'' (SPA) (CRWMS M&O 1997c) as the baseline reference document and further develops the functional requirements based on Project-directed changes, including incorporation of a new design basis waste stream and the applicable elements of Enhanced Design Alternative (EDA)-II, as identified in the ''License Application Design Selection Report'' (CRWMS M&O 1999e), which followed the initial SPA (baseline). The impacts of the EDA-II were almost entirely to the WHB. To meet the EDA-II thermal requirements, hotter fuel would be handled, therefore requiring a fuel-blending pool to be added to the WHB in order to age the hotter he1 at the repository and provide for commercial spent nuclear fuel (CSNF) blending. In addition to EDA

  10. Designing Abstractions for JavaScript Program Analysis

    DEFF Research Database (Denmark)

    Andreasen, Esben Sparre

    JavaScript is a widely used dynamic programming language. What started out as a client-side scripting language for browsers, is now used for large applications in many different settings. As for other dynamic languages, JavaScript makes it easy to write programs quickly without being constrained...... by the language, and programmers exploit that power to write highly dynamic programs. Automated tools for helping programmers and optimizing programs are used successfully for many programming languages. Unfortunately, the automated tools for JavaScript are not as good as for other programming languages....... The program analyses, that the automated tools are built upon, are poorly suited to deal with the highly dynamic nature of JavaScript programs. The lack of language restrictions on the programmer are detrimental to the quality of program analyses for JavaScript. The aim of this dissertation is to address...

  11. Harmonic Analysis : special program at the Nankai Institute of Mathematics

    CERN Document Server

    Deng, Dong-Gao; Zhou, Xing-Wei

    1991-01-01

    All papers in this volume are original (fully refereed) research reports by participants of the special program on Harmonic Analysis held in the Nankai Institute of Mathematics. The main themes include: Wavelets, Singular Integral Operators, Extemal Functions, H Spaces, Harmonic Analysis on Local Domains and Lie Groups, and so on. See also :G. David "Wavelets and Singular Integrals on Curves and Surfaces", LNM 1465,1991. FROM THE CONTENTS: D.C. Chang: Nankai Lecture in -Neumann Problem.- T.P. Chen, D.Z. Zhang: Oscillary Integral with Polynomial Phase.- D.G. Deng, Y.S. Han: On a Generalized Paraproduct Defined by Non-Convolution.- Y.S. Han: H Boundedness of Calderon-Zygmund Operators for Product Domains.- Z.X. Liu, S.Z. Lu: Applications of H|rmander Multiplier Theorem to Approximation in Real Hardy Spaces.- R.L. Long, F.S. Nie: Weighted Sobolev Inequality and Eigenvalue Estimates of Schr|dinger Operator.- A. McIntosh, Q. Tao: Convolution Singular Integral Operators on Lipschitz Curves.- Z.Y. Wen, L.M.Wu, Y.P. ...

  12. An Analysis on Distance Education Computer Programming Students' Attitudes Regarding Programming and Their Self-Efficacy for Programming

    Science.gov (United States)

    Ozyurt, Ozcan

    2015-01-01

    This study aims to analyze the attitudes of students studying computer programming through the distance education regarding programming, and their self-efficacy for programming and the relation between these two factors. The study is conducted with 104 students being thought with distance education in a university in the north region of Turkey in…

  13. Frequency Domain Computer Programs for Prediction and Analysis of Rail Vehicle Dynamics : Volume 1. Technical Report

    Science.gov (United States)

    1975-12-01

    Frequency domain computer programs developed or acquired by TSC for the analysis of rail vehicle dynamics are described in two volumes. Volume I defines the general analytical capabilities required for computer programs applicable to single rail vehi...

  14. PCOM: A Microcomputer Program that Performs a Principal Components Analysis.

    Science.gov (United States)

    Powers, Stephen

    1984-01-01

    This paper describes a microcomputer program that extracts principal components from a correlation matrix and rotates them to a varimax solution. Eigenvalues, variances associated with each component, unrotated component loadings, and varimax rotated loadings are output by the program. (Author)

  15. Mitochondrial Reactive Oxygen Species in Lipotoxic Hearts Induces Post-Translational Modifications of AKAP121, DRP1 and OPA1 That Promote Mitochondrial Fission.

    Science.gov (United States)

    Tsushima, Kensuke; Bugger, Heiko; Wende, Adam R; Soto, Jamie; Jenson, Gregory A; Tor, Austin R; McGlauflin, Rose; Kenny, Helena C; Zhang, Yuan; Souvenir, Rhonda; Hu, Xiao X; Black, Crystal L; Pereira, Renata O; Lira, Vitor A; Spitzer, Kenneth; Sharp, Terry L; Shoghi, Kooresh I; Sparagna, Genevieve C; Rog-Zielinska, Eva A; Kohl, Peter; Khalimonchuk, Oleh; Schaffer, Jean E; Abel, E Dale

    2017-11-01

    Rationale: Cardiac lipotoxicity, characterized by increased uptake, oxidation and accumulation of lipid intermediates, contributes to cardiac dysfunction in obesity and diabetes. However, mechanisms linking lipid overload and mitochondrial dysfunction are incompletely understood. Objective: To elucidate the mechanisms for mitochondrial adaptations to lipid overload in postnatal hearts in vivo. Methods and Results: Using a transgenic mouse model of cardiac lipotoxicity overexpressing long-chain acyl-CoA synthetase 1 in cardiomyocytes, we show that modestly increased myocardial fatty acid uptake leads to mitochondrial structural remodeling with significant reduction in minimum diameter. This is associated with increased palmitoyl-carnitine oxidation and increased reactive oxygen species (ROS) generation in isolated mitochondria. Mitochondrial morphological changes and elevated ROS generation are also observed in palmitate-treated neonatal rat ventricular cardiomyocytes (NRVCs). Palmitate exposure to NRVCs initially activates mitochondrial respiration, coupled with increased mitochondrial membrane potential and adenosine triphosphate (ATP) synthesis. However, long-term exposure to palmitate (> 8h) enhances ROS generation, which is accompanied by loss of the mitochondrial reticulum and a pattern suggesting increased mitochondrial fission. Mechanistically, lipid-induced changes in mitochondrial redox status increased mitochondrial fission by increased ubiquitination of A-kinase anchor protein (AKAP121) leading to reduced phosphorylation of DRP1 at Ser637 and altered proteolytic processing of OPA1. Scavenging mitochondrial ROS restored mitochondrial morphology in vivo and in vitro. Conclusions: Our results reveal a molecular mechanism by which lipid overload-induced mitochondrial ROS generation causes mitochondrial dysfunction by inducing post-translational modifications of mitochondrial proteins that regulate mitochondrial dynamics. These findings provide a novel

  16. Quantitative Security Analysis for Multi-threaded Programs

    NARCIS (Netherlands)

    Ngo, Minh Tri; Huisman, Marieke

    Quantitative theories of information flow give us an approach to relax the absolute confidentiality properties that are difficult to satisfy for many practical programs. The classical information-theoretic approaches for sequential programs, where the program is modeled as a communication channel

  17. Promoting Diversity through Program Websites: A Multicultural Content Analysis of School Psychology Program Websites

    Science.gov (United States)

    Smith, Leann V.; Blake, Jamilia J.; Graves, Scott L.; Vaughan-Jensen, Jessica; Pulido, Ryne; Banks, Courtney

    2016-01-01

    The recruitment of culturally and linguistically diverse students to graduate programs is critical to the overall growth and development of school psychology as a field. Program websites serve as an effective recruitment tool for attracting prospective students, yet there is limited research on how school psychology programs use their websites to…

  18. Do Loyalty Programs Enhance Behavioral Loyalty : An Empirical Analysis Accounting for Program Design and Competitive Effects

    NARCIS (Netherlands)

    Leenheer, J.; Bijmolt, T.H.A.; van Heerde, H.J.; Smidts, A.

    2002-01-01

    This paper studies the effects of loyalty programs on share-of-wallet using market-wide household panel data on supermarket purchases.We find that loyalty programs relate positively to share-of-wallet, but the programs differ in effectiveness and some are ineffective.Both a saving component and a

  19. The NASA/industry Design Analysis Methods for Vibrations (DAMVIBS) program: A government overview

    Science.gov (United States)

    Kvaternik, Raymond G.

    1993-01-01

    NASA-Langley, under the Design Analysis Methods for Vibrations (DAMVIBS) Program, set out in 1984 to establish the technology base needed by the rotorcraft industry for developing an advanced finite-element-based dynamics design analysis capability for vibrations. Considerable work has been done by the industry participants in the program since that time. Because the DAMVIBS Program is being phased out, a government/industry assessment of the program has been made to identify those accomplishments and contributions which may be ascribed to the program. The purpose of this paper is to provide an overview of the program and its accomplishments and contributions from the perspective of the government sponsoring organization.

  20. COMPPAP - COMPOSITE PLATE BUCKLING ANALYSIS PROGRAM (UNIX VERSION)

    Science.gov (United States)

    Smith, J. P.

    1994-01-01

    The Composite Plate Buckling Analysis Program (COMPPAP) was written to help engineers determine buckling loads of orthotropic (or isotropic) irregularly shaped plates without requiring hand calculations from design curves or extensive finite element modeling. COMPPAP is a one element finite element program that utilizes high-order displacement functions. The high order of the displacement functions enables the user to produce results more accurate than traditional h-finite elements. This program uses these high-order displacement functions to perform a plane stress analysis of a general plate followed by a buckling calculation based on the stresses found in the plane stress solution. The current version assumes a flat plate (constant thickness) subject to a constant edge load (normal or shear) on one or more edges. COMPPAP uses the power method to find the eigenvalues of the buckling problem. The power method provides an efficient solution when only one eigenvalue is desired. Once the eigenvalue is found, the eigenvector, which corresponds to the plate buckling mode shape, results as a by-product. A positive feature of the power method is that the dominant eigenvalue is the first found, which is this case is the plate buckling load. The reported eigenvalue expresses a load factor to induce plate buckling. COMPPAP is written in ANSI FORTRAN 77. Two machine versions are available from COSMIC: a PC version (MSC-22428), which is for IBM PC 386 series and higher computers and compatibles running MS-DOS; and a UNIX version (MSC-22286). The distribution medium for both machine versions includes source code for both single and double precision versions of COMPPAP. The PC version includes source code which has been optimized for implementation within DOS memory constraints as well as sample executables for both the single and double precision versions of COMPPAP. The double precision versions of COMPPAP have been successfully implemented on an IBM PC 386 compatible running

  1. Micrometeoroid and Orbital Debris (MMOD) Shield Ballistic Limit Analysis Program

    Science.gov (United States)

    Ryan, Shannon

    2013-01-01

    This software implements penetration limit equations for common micrometeoroid and orbital debris (MMOD) shield configurations, windows, and thermal protection systems. Allowable MMOD risk is formulated in terms of the probability of penetration (PNP) of the spacecraft pressure hull. For calculating the risk, spacecraft geometry models, mission profiles, debris environment models, and penetration limit equations for installed shielding configurations are required. Risk assessment software such as NASA's BUMPERII is used to calculate mission PNP; however, they are unsuitable for use in shield design and preliminary analysis studies. The software defines a single equation for the design and performance evaluation of common MMOD shielding configurations, windows, and thermal protection systems, along with a description of their validity range and guidelines for their application. Recommendations are based on preliminary reviews of fundamental assumptions, and accuracy in predicting experimental impact test results. The software is programmed in Visual Basic for Applications for installation as a simple add-in for Microsoft Excel. The user is directed to a graphical user interface (GUI) that requires user inputs and provides solutions directly in Microsoft Excel workbooks.

  2. Hazard screening application guide. Safety Analysis Report Update Program

    Energy Technology Data Exchange (ETDEWEB)

    None

    1992-06-01

    The basic purpose of hazard screening is to group precesses, facilities, and proposed modifications according to the magnitude of their hazards so as to determine the need for and extent of follow on safety analysis. A hazard is defined as a material, energy source, or operation that has the potential to cause injury or illness in human beings. The purpose of this document is to give guidance and provide standard methods for performing hazard screening. Hazard screening is applied to new and existing facilities and processes as well as to proposed modifications to existing facilities and processes. The hazard screening process evaluates an identified hazards in terms of the effects on people, both on-site and off-site. The process uses bounding analyses with no credit given for mitigation of an accident with the exception of certain containers meeting DOT specifications. The process is restricted to human safety issues only. Environmental effects are addressed by the environmental program. Interfaces with environmental organizations will be established in order to share information.

  3. Proof-of-Concept Oil Shale Facility Environmental Analysis Program

    Energy Technology Data Exchange (ETDEWEB)

    1990-11-01

    The objectives of the Project are to demonstrate: (1) the Modified In- Situ (MIS) shale oil extraction process and (2) the application of CFBC technology using oil shale, coal and waste gas streams as fuels. The project will focus on evaluating and improving the efficiency and environmental performance of these technologies. The project will be modest by commercial standards. A 17-retort MIS system is planned in which two retorts will be processed simultaneously. Production of 1206-barrels per calendar day of raw shale oil and 46-megawatts of electricity is anticipated. West Virginia University coordinated an Environmental Analysis Program for the Project. Experts from around the country were retained by WVU to prepare individual sections of the report. These experts were exposed to all of OOSI`s archives and toured Tract C-b and Logan Wash. Their findings were incorporated into this report. In summary, no environmental obstacles were revealed that would preclude proceeding with the Project. One of the most important objectives of the Project was to verify the environmental acceptability of the technologies being employed. Consequently, special attention will be given to monitoring environmental factors and providing state of the art mitigation measures. Extensive environmental and socioeconomic background information has been compiled for the Tract over the last 15 years and permits were obtained for the large scale operations contemplated in the late 1970`s and early 1980`s. Those permits have been reviewed and are being modified so that all required permits can be obtained in a timely manner.

  4. Needs Analysis of Blind Students in Teaching Practice Program

    OpenAIRE

    *, Iswahyuni; Junining, Esti; Dewi, Dian Novita; Linta, Alies Poetri; Suwarso, Pratnyawati Nuridi

    2015-01-01

    As an inclusive university, Brawijaya University has accepted students with special needs in some differentstudy programs. Two of those are blind / visually impaired students who enrol English Language EducationStudy Program in which the program prepares the students to be English teachers. As a consequence, thestudents must be ready to do teaching practice in a public school when they are in the seventh semester. Thisstudy is going to find out the problems of the visually impaired students i...

  5. Global Analysis of Neutrophil Responses to Neisseria gonorrhoeae Reveals a Self-Propagating Inflammatory Program

    Science.gov (United States)

    Sintsova, Anna; Sarantis, Helen; Islam, Epshita A.; Sun, Chun Xiang; Amin, Mohsen; Chan, Carlos H. F.; Stanners, Clifford P.; Glogauer, Michael; Gray-Owen, Scott D.

    2014-01-01

    An overwhelming neutrophil-driven response causes both acute symptoms and the lasting sequelae that result from infection with Neisseria gonorrhoeae. Neutrophils undergo an aggressive opsonin-independent response to N. gonorrhoeae, driven by the innate decoy receptor CEACAM3. CEACAM3 is exclusively expressed by human neutrophils, and drives a potent binding, phagocytic engulfment and oxidative killing of Opa-expressing bacteria. In this study, we sought to explore the contribution of neutrophils to the pathogenic inflammatory process that typifies gonorrhea. Genome-wide microarray and biochemical profiling of gonococcal-infected neutrophils revealed that CEACAM3 engagement triggers a Syk-, PKCδ- and Tak1-dependent signaling cascade that results in the activation of an NF-κB-dependent transcriptional response, with consequent production of pro-inflammatory cytokines. Using an in vivo model of N. gonorrhoeae infection, we show that human CEACAM-expressing neutrophils have heightened migration toward the site of the infection where they may be further activated upon Opa-dependent binding. Together, this study establishes that the role of CEACAM3 is not restricted to the direct opsonin-independent killing by neutrophils, since it also drives the vigorous inflammatory response that typifies gonorrhea. By carrying the potential to mobilize increasing numbers of neutrophils, CEACAM3 thereby represents the tipping point between protective and pathogenic outcomes of N. gonorrhoeae infection. PMID:25188454

  6. LTP - A Tutorial Program for Analysis of Linear Two - Ports

    Directory of Open Access Journals (Sweden)

    J. Valsa

    1993-12-01

    Full Text Available The paper describes basic possibilities offered by the program LTP (Linear Two-Ports in teaching electrial networks theory. At the same time the most important algorithms used in the program are briefly described. The program LTP analyses immittance and transfer functions of two-ports in the domain of complex variable p, in the frequency domain and in the time domain. The results can be obtained in symbolic, semisymbolic and numerical form (with optional graphical representation of the numerical results. The program is user friendly and can be used easily by anyone.

  7. Workplace Violence Training Programs for Health Care Workers: An Analysis of Program Elements.

    Science.gov (United States)

    Arbury, Sheila; Hodgson, Michael; Zankowski, Donna; Lipscomb, Jane

    2017-06-01

    Commercial workplace violence (WPV) prevention training programs differ in their approach to violence prevention and the content they present. This study reviews 12 such programs using criteria developed from training topics in the Occupational Safety and Health Administration's (OSHA) Guidelines for Preventing Workplace Violence for Healthcare and Social Service Workers and a review of the WPV literature. None of the training programs addressed all the review criteria. The most significant gap in content was the lack of attention to facility-specific risk assessment and policies. To fill this gap, health care facilities should supplement purchased training programs with specific training in organizational policies and procedures, emergency action plans, communication, facility risk assessment, and employee post-incident debriefing and monitoring. Critical to success is a dedicated program manager who understands risk assessment, facility clinical operations, and program management and evaluation.

  8. Strong and healthy in Primary School Klasse2000 Program, Germany: a Program Impact Pathways (PIP) analysis.

    Science.gov (United States)

    Dokter, Andrea; Horst, Brigitte

    2014-09-01

    Developing a Program Impact Pathways (PIP) diagram helps identify and clarify the key objectives, processes, activities, and evaluation indicators of school-based nutrition programs. The Mondelēz International Foundation has recently supported the development of PIP analyses for programs in seven countries around the world. The results were shared with other project organizers at a Healthy Lifestyles Program Evaluation Workshop held in Granada, Spain, 13-14 September 2013, under the auspices of the Mondelēz International Foundation. The objectives were to develop the PIP assessment of the Strong and Healthy in Primary School Klasse2000 Program in order to refine the primary, secondary, and tertiary objectives of the program; identify Critical Quality Control Points (CCPs); and identify core indicators of the program's impact on healthy lifestyles. The PIP report was developed based on detailed instructions provided prior to the workshop, taking into account the Klasse2000 Program evaluation reports. The following CCPs were identified: monitoring the qualifications and motivation of teaching staff (external health promoters and schoolteachers); assessing involvement of the students' environmental influences, including families, schools, and sponsors; and assessing the children's healthy lifestyle knowledge, attitudes, and behaviors before and after program exposure. The healthy lifestyle indicators identified were children's knowledge of healthy diets and health-enhancing physical activities; the availability of healthy breakfast and snacks; the frequency of consumption of fruits, vegetables, sweetened and unsweetened drinks,fast food, and sweets, as well as attitudes toward physical activity; and the frequency and extent of physical activity in school and during free time. Body mass index (BMI) was identified as the final outcome indicator. Developing a PIP report helped to focus the objectives of the program. Identifying CCPs helped draw attention to the

  9. Do Health Benefits Outweigh the Costs of Mass Recreational Programs? An Economic Analysis of Four Ciclovía Programs

    OpenAIRE

    Montes, Felipe; Sarmiento, Olga L.; Zarama, Roberto; Pratt, Michael; Wang, Guijing; Jacoby, Enrique; Schmid, Thomas L.; Ramos, Mauricio; Ruiz, Oscar; Vargas, Olga; Michel, Gabriel; Zieff, Susan G.; Valdivia, Juan Alejandro; Cavill, Nick; Kahlmeier, Sonja

    2011-01-01

    One promising public health intervention for promoting physical activity is the Ciclovía program. The Ciclovía is a regular multisectorial community-based program in which streets are temporarily closed for motorized transport, allowing exclusive access to individuals for recreational activities and physical activity. The objective of this study was to conduct an analysis of the cost–benefit ratios of physical activity of the Ciclovía programs of Bogotá and Medellín in Colombia, Guadalajara i...

  10. Analysis of School Food Safety Programs Based on HACCP Principles

    Science.gov (United States)

    Roberts, Kevin R.; Sauer, Kevin; Sneed, Jeannie; Kwon, Junehee; Olds, David; Cole, Kerri; Shanklin, Carol

    2014-01-01

    Purpose/Objectives: The purpose of this study was to determine how school districts have implemented food safety programs based on HACCP principles. Specific objectives included: (1) Evaluate how schools are implementing components of food safety programs; and (2) Determine foodservice employees food-handling practices related to food safety.…

  11. Analytic central path, sensitivity analysis and parametric linear programming

    NARCIS (Netherlands)

    A.G. Holder; J.F. Sturm; S. Zhang (Shuzhong)

    1998-01-01

    textabstractIn this paper we consider properties of the central path and the analytic center of the optimal face in the context of parametric linear programming. We first show that if the right-hand side vector of a standard linear program is perturbed, then the analytic center of the optimal face

  12. Analysis of Engineering Content within Technology Education Programs

    Science.gov (United States)

    Fantz, Todd D.; Katsioloudis, Petros J.

    2011-01-01

    In order to effectively teach engineering, technology teachers need to be taught engineering content, concepts, and related pedagogy. Some researchers posit that technology education programs may not have enough content to prepare technology teachers to teach engineering design. Certain technology teacher education programs have responded by…

  13. Effective Analysis of C Programs by Rewriting Variability

    DEFF Research Database (Denmark)

    Iosif-Lazar, Alexandru Florin; Melo, Jean; Dimovski, Aleksandar

    2017-01-01

    Context. Variability-intensive programs (program families) appear in many application areas and for many reasons today. Different family members, called variants, are derived by switching statically configurable options (features) on and off, while reuse of the common code is maximized. Inquiry...

  14. A Quasi-Experimental Analysis of Schoolwide Violence Prevention Programs

    Science.gov (United States)

    Barnes, Tia Navelene; Leite, Walter; Smith, Stephen W.

    2017-01-01

    Violence prevention programs are commonplace in today's schools, though reviews of the literature reveal mixed empirical findings on their effectiveness. Often, these programs include a variety of components such as social skills training, student mentoring, and activities designed to build a sense of school community that have not been tested for…

  15. Proof-of-Concept Oil Shale Facility Environmental Analysis Program

    Energy Technology Data Exchange (ETDEWEB)

    1990-11-01

    The objectives of the Project are to demonstrate: (1) the Modified In- Situ (MIS) shale oil extraction process and (2) the application of CFBC technology using oil shale, coal and waste gas streams as fuels. The project will focus on evaluating and improving the efficiency and environmental performance of these technologies. The project will be modest by commercial standards. A 17-retort MIS system is planned in which two retorts will be processed simultaneously. Production of 1206-barrels per calendar day of raw shale oil and 46-megawatts of electricity is anticipated. West Virginia University coordinated an Environmental Analysis Program for the Project. Experts from around the country were retained by WVU to prepare individual sections of the report. These experts were exposed to all of OOSI's archives and toured Tract C-b and Logan Wash. Their findings were incorporated into this report. In summary, no environmental obstacles were revealed that would preclude proceeding with the Project. One of the most important objectives of the Project was to verify the environmental acceptability of the technologies being employed. Consequently, special attention will be given to monitoring environmental factors and providing state of the art mitigation measures. Extensive environmental and socioeconomic background information has been compiled for the Tract over the last 15 years and permits were obtained for the large scale operations contemplated in the late 1970's and early 1980's. Those permits have been reviewed and are being modified so that all required permits can be obtained in a timely manner.

  16. Programmer's guide for the GNAT computer program (numerical analysis of stratification in supercritical oxygen)

    Science.gov (United States)

    Heinmiller, J. P.

    1971-01-01

    This document is the programmer's guide for the GNAT computer program developed under MSC/TRW Task 705-2, Apollo cryogenic storage system analysis, subtask 2, is reported. Detailed logic flow charts and compiled program listings are provided for all program elements.

  17. A Meta-Analysis of School-Based Bullying Prevention Programs' Effects on Bystander Intervention Behavior

    Science.gov (United States)

    Polanin, Joshua R.; Espelage, Dorothy L.; Pigott, Therese D.

    2012-01-01

    This meta-analysis synthesized bullying prevention programs' effectiveness at increasing bystander intervention in bullying situations. Evidence from 12 school-based programs, involving 12,874 students, indicated that overall the programs were successful (Hedges's g = 0.20, 95% confidence interval [CI] = 0.11 to 0.29, p = 0.001), with larger…

  18. Prevention of Child Sexual Abuse Victimization: A Meta Analysis of School Programs.

    Science.gov (United States)

    Rispens, Jan; Aleman, Andre; Goudena, Paul P.

    1997-01-01

    Meta-analysis of 16 evaluation studies of school programs aimed at the prevention of child sexual abuse victimization found significant and considerable mean postintervention and follow-up effect sizes, indicating that the programs were effective in teaching children sexual abuse concepts and self-protection skills. Program duration and content…

  19. The Opportunity Cost of Study Abroad Programs: An Economics-Based Analysis

    Science.gov (United States)

    Heitmann, George

    2008-01-01

    Most colleges and universities offer study abroad programs, and an increasing number of students participate in such programs. The cost of offering and promoting study abroad programs is often misunderstood and incorrectly assessed. This paper provides an analysis of study abroad costs that will be of general interest, but will be especially…

  20. 76 FR 65769 - Airport Improvement Program: Modifications to Benefit Cost Analysis (BCA) Threshold

    Science.gov (United States)

    2011-10-24

    ... Federal Aviation Administration Airport Improvement Program: Modifications to Benefit Cost Analysis (BCA... Airport Improvement Program (AIP) discretionary funds. On December 16, 2010, the FAA issued a Notice of... which BCAs are required from $5 million to $10 million in Airport Improvement Program (AIP...

  1. Evaluating Intangible Outcomes: Using Multiattribute Utility Analysis to Compare the Benefits and Costs of Social Programs

    Science.gov (United States)

    Selameab, Tehout; Yeh, Stuart S.

    2008-01-01

    Increasingly, program managers are required to evaluate programs with multiple outcomes against costs. This is difficult when program outcomes are not easily translated into a common metric. This article compares cost benefit analysis with Multiple Attribute Utility Technology and discusses the application of judgment in both analytical…

  2. Java vs. Python Coverage of Introductory Programming Concepts: A Textbook Analysis

    Science.gov (United States)

    McMaster, Kirby; Sambasivam, Samuel; Rague, Brian; Wolthuis, Stuart

    2017-01-01

    In this research, we compare two languages, Java and Python, by performing a content analysis of words in textbooks that describe important programming concepts. Our goal is to determine which language has better textbook support for teaching introductory programming courses. We used the TextSTAT program to count how often our list of concept…

  3. Analysis of NOx Budget Trading Program Units Brought into the CAIR NOx Ozone Season Trading Program

    Science.gov (United States)

    EPA analyzed the effect of having the large non-EGU units in the NBP and the CAIR NOX ozone season trading program and evaluated whether or not emissions from this group of units were reduced as a result of their inclusion in those trading programs.

  4. 76 FR 34286 - ITS Joint Program Office; Webinar on Connected Vehicle Infrastructure Deployment Analysis Report...

    Science.gov (United States)

    2011-06-13

    ... between vehicles, infrastructure, and personal communications devices to improve safety, mobility, and... ITS Joint Program Office; Webinar on Connected Vehicle Infrastructure Deployment Analysis Report... Connected Vehicle Infrastructure Deployment Analysis Report. The webinar will provide an opportunity for...

  5. Utilizing Collaborative Analysis of Student Learning in Educator Preparation Programs for Continuous Improvement

    Directory of Open Access Journals (Sweden)

    Susan Colby

    2016-12-01

    Full Text Available In this results-oriented era of accountability, educator preparation programs are called upon to provide comprehensive data related to student and program outcomes while also providing evidence of continuous improvement. Collaborative Analysis of Student Learning (CASL is one approach for fostering critical inquiry about student learning. Graduate educator preparation programs in our university used collaborative analysis as the basis for continuous improvement during an accreditation cycle. As authors of this study, we sought to better understand how graduate program directors and faculty used collaborative analysis to inform practice and improve programs. Our findings suggested that CASL has the potential to foster collective responsibility for student learning, but only with a strong commitment from administrators and faculty, purposefully designed protocols and processes, fidelity to the CASL method, and a focus on professional development. Through CASL, programs have the ability to produce meaningful data related to student and program outcomes and meet the requirements for accreditation.

  6. Geodezija od Mesopotamije do Globalnog geodetskog opažačkog sistema : Geodesy from Mesopotamie to Global Geodetic Observing System

    Directory of Open Access Journals (Sweden)

    Medžida Mulić

    2015-12-01

    Full Text Available Tokom šest milenijuma postojanja civilizacije na Zemlji, geodetske tehnike su doživjele teško sagledive promjene. Definicija i uloga geodezije su se mijenjale u skladu s tim promijenila. Geodezija (viša je evoluirala od svoje originalne klasične definicije da „proučava kretanja nebeskih tijela, oblik i dimenzije Zemlje“ u „znanost koja osim naprijed rečenog, proučava njene promjene i kompleksne dinamičke procese, koji djeluju unutar Zemlje, na njenoj površini i iznad njene površine, kao i u svemiru koji je okružuje. Rad predstavlja detaljan pregled geodetskih tehnika, instrumenata, katastra i kartografije kod starih civilizacija: Mesopotamije, starog Egipta, antičke Grčke, starog Rima, pa sve do Evropljana, između 17. stoljeća do modernog doba. Posebno su opisani geodetski radovi u Bosni i Hercegovini, od doba osmanlija, austro-ugarskog premjera, do savremenih dostignuća u polju premjera i primjene satelitskih modernih tehnika. Globalni geodetski opažački sistem-GGOS, glavna komponenta Internacionalne asocijacije za geodeziju, kao projekat za buduće generacije geodeta, opisan je na kraju. : During the six millennia of the existence of the civilization on the Earth, surveying techniques have been experienced difficult foreseeable changes. The definition and role of geodesy have been changing accordingly. Geodesy has evolved from its original classic definition that "studying the movements of celestial bodies, the shape and dimensions of the Earth" in the "science which, beside it noted above, studies its changes and complex dynamic processes that ongoing inside the Earth, on the surface, above its surfaces, and evironment. The paper is overview of the geodetic techniques and the surveying instruments, cadastre and cartography in the ancien civilizations: Mesopotamia, ancient Egypt, antic Greece, ancient Rome, to the Europeans, from the 17th century to modern times. A detailed description devoted to surveying and geodetic

  7. A computer program for planimetric analysis of digitized images

    DEFF Research Database (Denmark)

    Lynnerup, N; Lynnerup, O; Homøe, P

    1992-01-01

    bones as seen on X-rays. By placing the X-rays on a digitizer tablet and tracing the outline of the cell system, the area was calculated by the program. The calculated data and traced images could be stored and printed. The program is written in BASIC; necessary hardware is an IBM-compatible personal......Planimetrical measurements are made to calculate the area of an entity. By digitizing the entity the planimetrical measurements may be done by computer. This computer program was developed in conjunction with a research project involving measurement of the pneumatized cell system of the temporal...... computer, a digitizer tablet and a printer....

  8. Opas CrossFit -harjoitteluun

    OpenAIRE

    Knaapi, Matti

    2014-01-01

    CrossFit on laji, joka pyrkii edistämään terveyttä ja kuntoa. CrossFit saleja löytyy mailmalta yli 10 000 kappaletta. CrossFit -harjoittelussa pyritään parantamaan ihmisen kuntoa mahdollisimman laajalla skaalalla kehittämällä mm. voimaa, kestävyyttä, tarkkuutta, tasapainoa ja eri aineenvaihduntareittejä samanaikaisesti. Terveyden ja kunnon kehittämiseen kuuluu kuntoilun lisäksi myös muita osa-alueita. Ruokavalio ja kehonhuolto ovat tärkeitä osa-alueita hyvän kunnon saavuttamiseksi. Ruokav...

  9. Kenguruun! : opas keskoslapsen vanhemmille kenguruhoidosta

    OpenAIRE

    Viitanen, Anni

    2009-01-01

    Tämä opinnäytetyö on osa lapsen, nuoren ja lapsiperheen ohjaus -projektia. Projekti toteutetaan yhteistyössä Metropolia ammattikorkeakoulun Terveys- ja hoitoalan, HYKS:n Naisten- ja lastentautien tulosyksikön sekä pitkäaikaissairaiden lasten hoitoon ja kuntoutukseen liittyvien kolmannen sektorin yhdistysten kanssa. Projektin tarkoituksena on selvittää, millaista on lapsen, nuoren ja lapsiperheen voimavaroja tukeva ohjaus ja tuottaa uusia hoitotyön ohjausmenetelmiä- ja sisältöjä keskeisiin ohj...

  10. Future-based Static Analysis of Message Passing Programs

    Directory of Open Access Journals (Sweden)

    Wytse Oortwijn

    2016-06-01

    Full Text Available Message passing is widely used in industry to develop programs consisting of several distributed communicating components. Developing functionally correct message passing software is very challenging due to the concurrent nature of message exchanges. Nonetheless, many safety-critical applications rely on the message passing paradigm, including air traffic control systems and emergency services, which makes proving their correctness crucial. We focus on the modular verification of MPI programs by statically verifying concrete Java code. We use separation logic to reason about local correctness and define abstractions of the communication protocol in the process algebra used by mCRL2. We call these abstractions futures as they predict how components will interact during program execution. We establish a provable link between futures and program code and analyse the abstract futures via model checking to prove global correctness. Finally, we verify a leader election protocol to demonstrate our approach.

  11. Future-based Static Analysis of Message Passing Programs

    NARCIS (Netherlands)

    Orchard, Dominic; Oortwijn, Wytse Hendrikus Marinus; Yoshida, Nobuko; Blom, Stefan; Huisman, Marieke

    Message passing is widely used in industry to develop programs consisting of several distributed communicating components. Developing functionally correct message passing software is very challenging due to the concurrent nature of message exchanges. Nonetheless, many safety-critical applications

  12. Program For Analysis Of Metal-Matrix Composites

    Science.gov (United States)

    Murthy, P. L. N.; Mital, S. K.

    1994-01-01

    METCAN (METal matrix Composite ANalyzer) is computer program used to simulate computationally nonlinear behavior of high-temperature metal-matrix composite structural components in specific applications, providing comprehensive analyses of thermal and mechanical performances. Written in FORTRAN 77.

  13. A national analytical quality assurance program: Developing guidelines and analytical tools for the forest inventory and analysis program

    Science.gov (United States)

    Phyllis C. Adams; Glenn A. Christensen

    2012-01-01

    A rigorous quality assurance (QA) process assures that the data and information provided by the Forest Inventory and Analysis (FIA) program meet the highest possible standards of precision, completeness, representativeness, comparability, and accuracy. FIA relies on its analysts to check the final data quality prior to release of a State’s data to the national FIA...

  14. Office of Nuclear Energy Knowledge Management Program Situational Analysis Report

    Energy Technology Data Exchange (ETDEWEB)

    Kimberlyn C. Mousseau

    2011-12-01

    Knowledge management (KM) has been a high priority for the Department of Energy (DOE) Office of Nuclear Energy (NE) for the past several years. NE Programs are moving toward well-established knowledge management practices and a formal knowledge management program has been established. Knowledge management is being practiced to some level within each of the NE programs. Although it continues to evolve as NE programs evolve, a formal strategic plan that guides the implementation of KM has been developed. Despite the acceptance of KM within DOE NE, more work is necessary before the NE KM program can be considered fully successful. Per Dr. David J. Skyrme[1], an organization typically moves through the following evolutionary phases: (1) Ad-hoc - KM is being practiced to some level in some parts of the organization; (2) Formal - KM is established as a formal project or program; (3) Expanding - the use of KM as a discipline grows in practice across different parts of the organization; (4) Cohesive - there is a degree of coordination of KM; (5) Integrated - there are formal standards and approaches that give every individual access to most organizational knowledge through common interfaces; and (6) Embedded - KM is part-and-parcel of everyday tasks; it blends seamlessly into the background. According to the evolutionary phases, the NE KM program is operating at the two lower levels, Ad-hoc and Formal. Although KM is being practiced to some level, it is not being practiced in a consistent manner across the NE programs. To be fully successful, more emphasis must be placed on establishing KM standards and processes for collecting, organizing, sharing and accessing NE knowledge. Existing knowledge needs to be prioritized and gathered on a routine basis, its existence formally recorded in a knowledge inventory. Governance to ensure the quality of the knowledge being used must also be considered. For easy retrieval, knowledge must be organized according to a taxonomy that

  15. Analysis of industrial pollution prevention programs in selected Asian countries

    Energy Technology Data Exchange (ETDEWEB)

    Chiu, S.Y. [Argonne National Lab., IL (United States). Environmental Assessment Div.]|[East-West Center, Honolulu, HI (United States)

    1995-05-01

    Industrialization in developing countries is causing increasing environmental damage. Pollution prevention (P2) is an emerging environmental concept that could help developing countries achieve leapfrog goals, bypassing old and pollutive technologies and minimizing traditional control practices. The current P2 promotion activities in Hong Kong, the Republic of Korea, the Philippines, Singapore, Taiwan, and Thailand are discussed. These programs, generally initiated in the last 5 years, are classified into five categories: awareness promotion, education and training, information transfer, technical assistance, and financial incentives. All important at the early stages of P2 promotion, these programs should inform industries of the benefits of P2 and help them identify applicable P2 measures. Participation in these programs is voluntary. The limited data indicate that adoption of P2 measures in these countries is not yet widespread. Recommendations for expanding P2 promotion activities include (1) strengthening the design and enforcement of environmental regulations; (2) providing P2 training and education to government workers, nongovernmental organizations and labor unions officials, university faculties, and news media; (3) tracking the progress of P2 programs; (4) implementing selected P2 mandatory measures; (5) identifying cleaner production technologies for use in new facilities; (6) implementing special programs for small and medium enterprises; and (7) expanding P2 promotion to other sectors, such as agriculture and transportation, and encouraging green design and green consumerism.

  16. Analysis Dataset - West Coast Groundfish Observer Program and At-Sea Hake Observer Program data collection, analysis and reporting

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Observer programs are the most comprehensive fishery dependent data collection system for total mortality estimation, protected species monitoring and discard data...

  17. PARS: Programs for Analysis and Resizing of Structures, user manual

    Science.gov (United States)

    Haftka, R. T.; Prasad, B.; Tsach, U.

    1979-01-01

    PARS processors and their use, flutter analysis, sensitivity analysis for stresses, and resizing are presented. Design variable definition and interface with finite element model, static constraints and their derivatives, flutter derivatives, and optimization are discussed.

  18. Policy Options Analysis of Assistance to Firefighters Grant Program

    Science.gov (United States)

    2014-03-01

    multi-goal policy analysis. Professor Eugene Bardach , at the University of California, Berkeley, summarizes a multi-goal policy analysis as...much as four years of war. Retrieved March 3, 2011, from http:/www.msnbc.msn.com/id/9281409/ Bardach , E. (2009). A practical guide for policy analysis

  19. Constraints and Logic Programming in Grammars and Language Analysis

    DEFF Research Database (Denmark)

    Christiansen, Henning

    2014-01-01

    analysis. With a tool such as Constraint Handling Rules, CHR, to be ex- plained below, the grammar writer or programmer working with language analysis can define his or her own constraint solvers specifically tailored for the linguistic problems at hand. We concentrate on grammars and lan- guage analysis...

  20. FLUT - A program for aeroelastic stability analysis. [of aircraft structures in subsonic flow

    Science.gov (United States)

    Johnson, E. H.

    1977-01-01

    A computer program (FLUT) that can be used to evaluate the aeroelastic stability of aircraft structures in subsonic flow is described. The algorithm synthesizes data from a structural vibration analysis with an unsteady aerodynamics analysis and then performs a complex eigenvalue analysis to assess the system stability. The theoretical basis of the program is discussed with special emphasis placed on some innovative techniques which improve the efficiency of the analysis. User information needed to efficiently and successfully utilize the program is provided. In addition to identifying the required input, the flow of the program execution and some possible sources of difficulty are included. The use of the program is demonstrated with a listing of the input and output for a simple example.

  1. Innovation and entrepreneurship programs in US medical education: a landscape review and thematic analysis.

    Science.gov (United States)

    Niccum, Blake A; Sarker, Arnab; Wolf, Stephen J; Trowbridge, Matthew J

    2017-01-01

    Training in innovation and entrepreneurship (I&E) in medical education has become increasingly prevalent among medical schools to train students in complex problem solving and solution design. We aim to characterize I&E education in US allopathic medical schools to provide insight into the features and objectives of this growing field. I&E programs were identified in 2016 via structured searches of 158 US allopathic medical school websites. Program characteristics were identified from public program resources and structured phone interviews with program directors. Curricular themes were identified via thematic analysis of program resources, and themes referenced by >50% of programs were analyzed. Thirteen programs were identified. Programs had a median age of four years, and contained a median of 13 students. Programs were led by faculty from diverse professional backgrounds, and all awarded formal recognition to graduates. Nine programs spanned all four years of medical school and ten programs required a capstone project. Thematic analysis revealed seven educational themes (innovation, entrepreneurship, technology, leadership, healthcare systems, business of medicine, and enhanced adaptability) and two teaching method themes (active learning, interdisciplinary teaching) referenced by >50% of programs. The landscape of medical school I&E programs is rapidly expanding to address newfound skills needed by physicians due to ongoing changes in healthcare, but programs remain relatively few and small compared to class size. This landscape analysis is the first review of I&E in medical education and may contribute to development of a formal educational framework or competency model for current or future programs. AAMC: American Association of Medical Colleges; AMA: American Medical Association; I&E: Innovation and entrepreneurship.

  2. [A SWOT (strengths, weaknesses, opportunities, threats) analysis of the current immunization program in Zhejiang Province].

    Science.gov (United States)

    He, Han-Qing; Ling, Luo-Ya; Xu, Xu-Qing

    2009-02-01

    To know the status of Immunization program in Zhejiang Province. The investigation on immunization program in zhejiang province was conducted, and the SWOT analysis was corducted to make a comprehensive evaluation. 11 cities, 22 counties and 44 towns were investigated in this study, and the current immunization program in Zhejiang province were explored by SWOT analysis. The SWOT Matrix, includes SO (strength-opportunity), ST (strength-threat), WO (weakness-opportunity) and WT (weakness-threat) can apply to make optimal strategy for the development of expanded program on immunization.

  3. Human Systems Engineering and Program Success - A Retrospective Content Analysis

    Science.gov (United States)

    2016-01-01

    generic program. It is not intended to reflect the time dedicated to associated phase activity. LEGEND : = Decision Point CDD = Capability Development...Beverly G. Knapp. Also, Dr. Holly A. H. Handley and Jeffrey Thomas provided techniques, data, and advice. Former col- leagues Susan Archer, Chris Plott

  4. Formal analysis of name accessing in programming languages

    Energy Technology Data Exchange (ETDEWEB)

    Smith, Carol Lynn [Iowa State Univ., Ames, IA (United States)

    1975-10-01

    One of the main purposes of a programming language is to provide a framework within which a user can convey the specification of a task to an information processing system. A model is proposed in which name accessing conventions can be analyzed and compared.

  5. Analysis of Students' Errors on Linear Programming at Secondary ...

    African Journals Online (AJOL)

    The purpose of this study was to identify secondary school students' errors on linear programming at 'O' level. It is based on the fact that students' errors inform teaching hence an essential tool for any serious mathematics teacher who intends to improve mathematics teaching. The study was guided by a descriptive survey ...

  6. An Analysis of Writing Coach Programs on American Daily Newspapers.

    Science.gov (United States)

    Laakaniemi, Ray

    A survey of 239 newspapers was conducted to explore the use of writing coach programs at these papers. The coaches' backgrounds, newsroom factors, specific writing problems, budgetary considerations, and implications for journalism education were all explored, as were the perceptions of editors supervising the writing coaches. Of the 239 papers…

  7. Networks Analysis of a Regional Ecosystem of Afterschool Programs

    Science.gov (United States)

    Russell, Martha G.; Smith, Marc A.

    2011-01-01

    Case studies have documented the impact of family-school-community collaboration in afterschool programs on increasing awareness about the problems of at-risk youth, initiating dialogue among leaders and community representatives, developing rich school-based information systems, and demonstrating how to build strong relationships between public…

  8. An economic analysis of leniency programs in antitrust law

    NARCIS (Netherlands)

    Hinloopen, J.

    2003-01-01

    Within a dynamic market environment the forces that drive the effectiveness of leniency programs in antitrust law are analyzed. This effectiveness unambigously is enhanced by (i) increasing the reduction in fine payments in return for reporting a cartel, and (ii) increasing the expected per-period

  9. A Critical Analysis of Attribute Development Programs for Army Leaders

    Science.gov (United States)

    2016-06-10

    consisting of books, articles, web sites, mission statements, program descriptions, and policies approved for public release. Attribute coverage of each...H. Jaycox, Invisible Wounds of War Psychological and Cognitive Injuries, their Consequences, and Services to Assist Recovery (Santa Monica, CA...methods:113 1. Online assessment and self-development training through the Army Fit web site. 112

  10. An Exploratory Analysis of Public and Private Correctional Education Programs

    Science.gov (United States)

    Sadeghi, Leila

    2009-01-01

    As prison populations soar at unprecedented rates, the need for high quality education behind bars has never been greater. Prison education programs are the vehicle for reform and may be the solution to curtailing an ever-growing prison population. Yet, as the public sector increasingly contracts with the private sector for prison management,…

  11. A computer program for analysis of fuelwood harvesting costs

    Science.gov (United States)

    George B. Harpole; Giuseppe Rensi

    1985-01-01

    The fuelwood harvesting computer program (FHP) is written in FORTRAN 60 and designed to select a collection of harvest units and systems from among alternatives to satisfy specified energy requirements at a lowest cost per million Btu's as recovered in a boiler, or thousand pounds of H2O evaporative capacity kiln drying. Computed energy costs are used as a...

  12. Collaboration Practices: An Analysis Within an Army Acquisition Program Office

    Science.gov (United States)

    2014-03-01

    8, DASC, TPO , PEO Sensor, PEO Platform, various platform Product Management Offices, contracting staff, and systems integrators. Please take this...Questions: 1) Who is involved in the Sensor Stakeholder Community? a) Program Management Office b) HQDA G-3/5/7 c) HQDA G-8, DASC d) TPO e) PEO Sensor

  13. Microfinance Programs in Uganda: An Analysis of Household ...

    African Journals Online (AJOL)

    This paper identifies a model of low-income household participation in microfinance credit programs and the effects on investment behavior from repeated access to these institutions using evidence from household survey data. The primary focus is on changes in household investment behavior, not the assessment of ...

  14. Analysis of 2014's Thirty Best Undergraduate Accounting Programs

    Science.gov (United States)

    Adkins, Darlene A.; Geddie, Mary F.; Moore, Paula Hearn; Griffin, Richard B.

    2016-01-01

    This paper examines primarily the courses in the accounting major and a portion of the business core of the best thirty accounting programs in the United States as identified by the Accounting Degree Review. A thorough examination of each school's web site has been conducted to gather current (2014) information concerning the requirements for a…

  15. Analysis of System Training Impact for Major Defense Acquisition Programs

    Science.gov (United States)

    2011-08-01

    Dogfighting, cheating death, and Hollywood glory as one of America’s best fighter jocks. New York: Skyhorse Publishing. Booher, H. (1990...ensure that there are no false starts or misunderstandings later in the process. Normally, cost estimates are sponsored by a system program office and

  16. An Analysis of the Navy’s Voluntary Education Program

    Science.gov (United States)

    2007-03-01

    and to provide a road map to earn a GEB diploma or a degree (Associate, Bachelor, or Graduate). Navy Campus also administers the ACT, SAT , CLEP, and...was that the study combined all the different components, (TA, PACE, SLC etc.), of the VOLED program together. This can skew the results because

  17. A Content Analysis of Problematic Behavior in Counselor Education Programs

    Science.gov (United States)

    Brown, Maranda

    2013-01-01

    Counselor education programs are obligated by accreditation standards and professional codes of ethics to identify counselors-in-training whose academic, clinical, and personal performance indicate problematic behavior that would potentially prevent them from entering the profession (McAdams, Foster, & Ward, 2007; Rust, Raskin, & Hill,…

  18. Police AED programs: a systematic review and meta-analysis.

    Science.gov (United States)

    Husain, Sofia; Eisenberg, Mickey

    2013-09-01

    Approximately 359,400 out-of-hospital cardiac arrests occur in the United States every year, and around 60% of them are treated by emergency medical services (EMS) personnel. In order to alleviate the impact of this public health burden, some communities have trained police officers as first responders so that they can provide cardiopulmonary resuscitation and defibrillation to cardiac arrest patients. This paper is a review of the current literature on the impact of police automated external defibrillators (AEDs) programs in these communities. A literature search of electronic journal databases was conducted to identify articles that evaluated police AED programs and quantified survival rates. The 10 articles that met the inclusion criteria were very heterogeneous in terms of study design, controlling for confounders, outcome definitions, and comparison groups. Two communities found a statistically significant difference in survival and 6 studies reported a statistically significant difference in time to defibrillation after the implementation of these programs. The weighted mean survival rate of the study groups was higher than that of the control groups (pAED programs. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  19. FREQFIT: Computer program which performs numerical regression and statistical chi-squared goodness of fit analysis

    Energy Technology Data Exchange (ETDEWEB)

    Hofland, G.S.; Barton, C.C.

    1990-10-01

    The computer program FREQFIT is designed to perform regression and statistical chi-squared goodness of fit analysis on one-dimensional or two-dimensional data. The program features an interactive user dialogue, numerous help messages, an option for screen or line printer output, and the flexibility to use practically any commercially available graphics package to create plots of the program`s results. FREQFIT is written in Microsoft QuickBASIC, for IBM-PC compatible computers. A listing of the QuickBASIC source code for the FREQFIT program, a user manual, and sample input data, output, and plots are included. 6 refs., 1 fig.

  20. A meta-analysis of psychoeduational programs for coronary heart disease patients.

    Science.gov (United States)

    Dusseldorp, E; van Elderen, T; Maes, S; Meulman, J; Kraaij, V

    1999-09-01

    In a meta-analysis of 37 studies, the effects of psychoeducational (health education and stress management) programs for coronary heart disease patients were examined. The results suggest that these programs yielded a 34% reduction in cardiac mortality; a 29% reduction in recurrence of myocardial infarction (MI); and significant (p psychoeducational programs were found in regard to coronary bypass surgery, anxiety, or depression. The results also suggest that cardiac rehabilitation programs that were successful on proximal targets (systolic blood pressure, smoking behavior, physical exercise, emotional distress) were more effective on distal targets (cardiac mortality and MI recurrences) than programs without success on proximal targets.

  1. Sensitivity Analysis of Linear Programming and Quadratic Programming Algorithms for Control Allocation

    Science.gov (United States)

    Frost, Susan A.; Bodson, Marc; Acosta, Diana M.

    2009-01-01

    The Next Generation (NextGen) transport aircraft configurations being investigated as part of the NASA Aeronautics Subsonic Fixed Wing Project have more control surfaces, or control effectors, than existing transport aircraft configurations. Conventional flight control is achieved through two symmetric elevators, two antisymmetric ailerons, and a rudder. The five effectors, reduced to three command variables, produce moments along the three main axes of the aircraft and enable the pilot to control the attitude and flight path of the aircraft. The NextGen aircraft will have additional redundant control effectors to control the three moments, creating a situation where the aircraft is over-actuated and where a simple relationship does not exist anymore between the required effector deflections and the desired moments. NextGen flight controllers will incorporate control allocation algorithms to determine the optimal effector commands and attain the desired moments, taking into account the effector limits. Approaches to solving the problem using linear programming and quadratic programming algorithms have been proposed and tested. It is of great interest to understand their relative advantages and disadvantages and how design parameters may affect their properties. In this paper, we investigate the sensitivity of the effector commands with respect to the desired moments and show on some examples that the solutions provided using the l2 norm of quadratic programming are less sensitive than those using the l1 norm of linear programming.

  2. Constraint Solver Techniques for Implementing Precise and Scalable Static Program Analysis

    DEFF Research Database (Denmark)

    Zhang, Ye

    solver using unification we could make a program analysis easier to design and implement, much more scalable, and still as precise as expected. We present an inclusion constraint language with the explicit equality constructs for specifying program analysis problems, and a parameterized framework...... data flow analyses for C language, we demonstrate a large amount of equivalences could be detected by off-line analyses, and they could then be used by a constraint solver to significantly improve the scalability of an analysis without sacrificing any precision.......As people rely on all kinds of software systems for almost every aspect of their lives, how to ensure the reliability of software is becoming more and more important. Program analysis, therefore, becomes more and more important for the software development process. Static program analysis helps...

  3. Alternatives Analysis for the Resumption of Transient Testing Program

    Energy Technology Data Exchange (ETDEWEB)

    Lee Nelson

    2013-11-01

    An alternatives analysis was performed for resumption of transient testing. The analysis considered eleven alternatives – including both US international facilities. A screening process was used to identify two viable alternatives from the original eleven. In addition, the alternatives analysis includes a no action alternative as required by the National Environmental Policy Act (NEPA). The alternatives considered in this analysis included: 1. Restart the Transient Reactor Test Facility (TREAT) 2. Modify the Annular Core Research Reactor (ACRR) which includes construction of a new hot cell and installation of a new hodoscope. 3. No Action

  4. Syntactic Accidents in Program Analysis: On the Impact of the CPS Transformation

    DEFF Research Database (Denmark)

    Daniel, Damian; Danvy, Olivier

    2000-01-01

    We show that a non-duplicating transformation into Continuation-Passing Style (CPS) has no effect on control-flow analysis, a positive effect on binding-time analysis for traditional partial evaluation, and no effect on binding-time analysis for continuation-based partial evaluation: a monovariant...... control-flow analysis yields equivalent results on a direct-style program and on its CPS counterpart, a monovariant binding-time analysis yields less precise results on a direct-style program than on its CPS counterpart, and an enhanced monovariant binding-time analysis yields equivalent results...... on a direct-style program and on its CPS counterpart. Our proof technique amounts to constructing the CPS counterpart of flow information and of binding times. Our results formalize and confirm a folklore theorem about traditional binding-time analysis, namely that CPS has a positive effect on binding times...

  5. Syntactic accidents in program analysis: on the impact of the CPS transformation

    DEFF Research Database (Denmark)

    Damian, Daniel; Danvy, Olivier

    2003-01-01

    We show that a non-duplicating transformation into Continuation-Passing Style (CPS) has no effect on control-flow analysis, a positive effect on binding-time analysis for traditional partial evaluation, and no effect on binding-time analysis for continuation-based partial evaluation: a monovariant...... control-flow analysis yields equivalent results on a direct-style program and on its CPS counterpart, a monovariant binding-time analysis yields less precise results on a direct-style program than on its CPS counterpart, and an enhanced monovariant binding-time analysis yields equivalent results...... on a direct-style program and on its CPS counterpart. Our proof technique amounts to constructing the CPS counterpart of flow information and of binding times. Our results formalize and confirm a folklore theorem about traditional binding-time analysis, namely that CPS has a positive effect on binding times...

  6. Reformulating the Tax Incentive Program in Jordan: Analysis and Recommendations

    OpenAIRE

    Duanjie Chen

    2004-01-01

    The paper summarizes the main weaknesses of Jordan’s current incentive program. Because of these weaknesses, Jordan’s long history of investment incentives has proven not to attract significant capital investment in areas favored by government. Instead, these measures have simply eroded the base for tax revenue. The paper compares Jordan to its major competitors for foreign investment with the region, namely Egypt, Israel, Tunisia, and the United Arab Emirates (UAE)/Dubai. The paper makes fou...

  7. Sensitivity analysis of risk assessment programs to various input parameters.

    Science.gov (United States)

    Vadász, Z; Hassanien, M A; László, E; Dura, G

    2000-07-01

    HESP 2.b risk assessment program was studied in detail concerning the effect of changing different input parameters for the output ADI values calculated by the program. We used the standard Netherlands 1.0 scenario offered by the program. With this we fixed a lot of input parameters which define the area, human and animal recipient parameters etc. The remaining 31 unfixed parameters were fixed at first to "BASE" input values and the BASE output values were calculated by HESP. Later we chose only one parameter at a time and changed it to an another value. The calculated ADI values were then compared to BASE output values. Seven parameters (soil type, soil usage, site length, soil pH, groundwater fraction in drinking water, basement floor type and Qev) were studied. We found, that changing soil pH or Qev have not any influence on the output ADI values in case of any contaminant. Soil type change has not any effect on the output ADI value in case of Pb or Cd but it seems to play important role in all cases of the four organic material we investigated. Changing soil usage have influence on the output ADI value almost in every case. It seems to be linear relation between the maximal concentration of contaminant and calculated ADI. Changing the site length and basement floor type gave in some cases different ADI values compared to BASE values. If we alter the groundwater fraction in drinking water we got usually different ADI values. With Risc Human risk assessment program we got similar results: nor the changes in soil type, site diameter or soil pH gave any changes in output ADI values. Our results hint that using HESP and Risc Human requires enhanced caution.

  8. A Political Economy Analysis of Turkey's Health Transformation Program

    OpenAIRE

    Bump, Jesse B; Powers Sparkes, Susan

    2014-01-01

    Beginning in 2003, Turkey initiated a series of reforms under the Health Transformation Program (HTP) that over the past decade have reshaped the health system. Understanding the political economy of this process is important for the future of Universal Health Coverage (UHC) in Turkey, and also for many other countries and the development agencies that assist them. This report analyzes the historical context and complex political economy challenges of the reform. Our findings are ...

  9. Test Program for the Performance Analysis of DNS64 Servers

    Directory of Open Access Journals (Sweden)

    Gábor Lencse

    2015-09-01

    Full Text Available In our earlier research papers, bash shell scripts using the host Linux command were applied for testing the performance and stability of different DNS64 server imple­mentations. Because of their inefficiency, a small multi-threaded C/C++ program (named dns64perf was written which can directly send DNS AAAA record queries. After the introduction to the essential theoretical background about the structure of DNS messages and TCP/IP socket interface programming, the design decisions and implementation details of our DNS64 performance test program are disclosed. The efficiency of dns64perf is compared to that of the old method using bash shell scripts. The result is convincing: dns64perf can send at least 95 times more DNS AAAA record queries per second. The source code of dns64perf is published under the GNU GPLv3 license to support the work of other researchers in the field of testing the performance of DNS64 servers.

  10. Content Analysis of Food Advertising in Iranian Children's Television Programs.

    Science.gov (United States)

    Amini, Maryam; Omidvar, Nasrin; Yeatman, Heather; Shariat-Jafari, Shadab; Eslami-Amirabadi, Maryam; Zahedirad, Malihe

    2014-10-01

    Advertisements can influence children's health related behaviors. Television advertisements are the main avenues directing commercials at children in Iran. This study aimed to explore the content of food advertisement during children's television programs in 2007-8 and to compare it with those reported in 2000. All advertisements broadcasted before, during, and after children's programs aired on two major Iran national television networks were videotaped for a period of 4 weeks during 2007-8. For each advertisement, type of product(s) and mode of presentation (s) were coded. A total of 229 television advertisements were broadcasted. Food commercials were the most frequent group (31%) across the two channels. Among the food products advertised, calorie dense foods, including chocolate, soft drinks, extruded cereals, ice cream, cookies and candies were the most frequent. The appeal mainly used in television food advertisements was "stimulation of hunger/thirst" (38.5%). The advertisements were mostly presented as animations (54%) and the messages used were mainly directed to good taste. Although the total number of food advertisements during children's television programs has decreased but the consumption of high fat, high sugar, low nutrient dense foods continues to be promoted. Policies to address the issue should be scrutinized.

  11. Analysis of the efficiency of the linearization techniques for solving multi-objective linear fractional programming problems by goal programming

    Directory of Open Access Journals (Sweden)

    Tunjo Perić

    2017-01-01

    Full Text Available This paper presents and analyzes the applicability of three linearization techniques used for solving multi-objective linear fractional programming problems using the goal programming method. The three linearization techniques are: (1 Taylor’s polynomial linearization approximation, (2 the method of variable change, and (3 a modification of the method of variable change proposed in [20]. All three linearization techniques are presented and analyzed in two variants: (a using the optimal value of the objective functions as the decision makers’ aspirations, and (b the decision makers’ aspirations are given by the decision makers. As the criteria for the analysis we use the efficiency of the obtained solutions and the difficulties the analyst comes upon in preparing the linearization models. To analyze the applicability of the linearization techniques incorporated in the linear goal programming method we use an example of a financial structure optimization problem.

  12. Ca analysis: An Excel based program for the analysis of intracellular calcium transients including multiple, simultaneous regression analysis☆

    Science.gov (United States)

    Greensmith, David J.

    2014-01-01

    Here I present an Excel based program for the analysis of intracellular Ca transients recorded using fluorescent indicators. The program can perform all the necessary steps which convert recorded raw voltage changes into meaningful physiological information. The program performs two fundamental processes. (1) It can prepare the raw signal by several methods. (2) It can then be used to analyze the prepared data to provide information such as absolute intracellular Ca levels. Also, the rates of change of Ca can be measured using multiple, simultaneous regression analysis. I demonstrate that this program performs equally well as commercially available software, but has numerous advantages, namely creating a simplified, self-contained analysis workflow. PMID:24125908

  13. CRITICAL ANALYSIS OF THE EXTREME PROGRAMMING (XP) PROJECT MANAGEMENT METHODOLOGY IN THE INFORMATION TECHNOLOGY FIELD

    OpenAIRE

    Ionel NĂFTĂNĂILĂ; Ivona ORZEA

    2009-01-01

    Extreme Programming represents a modern Project Management methodology, being a part of AGILE methodologies. The present paper has the purpose of making a critical analysis of the Extreme Programming (XP) from the point of view of advantages and disadvantages that it implies, both from a theoretical and practical approach. From the theoretical point of view the paper will present the main contributions in the Extreme Programming literature, analyzing in the same time the main characteristics ...

  14. Current Work in Energy Analysis (Energy Analysis Program -1996 Annual Report)

    Energy Technology Data Exchange (ETDEWEB)

    Energy Analysis Program

    1998-03-01

    This report describes the work that Environmental Energy Technologies Division of Lawrence Berkeley National Laboratory has been doing most recently. One of our proudest accomplishments is the publication of Scenarios of U.S. Carbon Reductions, an analysis of the potential of energy technologies to reduce carbon emissions in the U.S. This analysis played a key role in shaping the U.S. position on climate change in the Kyoto Protocol negotiations. Our participation in the fundamental characterization of the climate change issue by the IPCC is described. We are also especially proud of our study of ''leaking electricity,'' which is stimulating an international campaign for a one-watt ceiling for standby electricity losses from appliances. This ceiling has the potential to save two-thirds of the 5% of U.S. residential electricity currently expended on standby losses. The 54 vignettes contained in the following pages summarize results of research. activities ranging in scale from calculating the efficacy of individual lamp ballasts to estimating the cost-effectiveness of the national ENERGY STAR{reg_sign} labeling program, and ranging in location from a scoping study of energy-efficiency market transformation in California to development of an energy-efficiency project in the auto parts industry in Shandong Province, China. These are the intellectual endeavors of a talented team of researchers dedicated to public service.

  15. Integrated Data Collection Analysis (IDCA) Program - Statistical Analysis of RDX Standard Data Sets

    Energy Technology Data Exchange (ETDEWEB)

    Sandstrom, Mary M. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Brown, Geoffrey W. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Preston, Daniel N. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Pollard, Colin J. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Warner, Kirstin F. [Naval Surface Warfare Center (NSWC), Indian Head, MD (United States). Indian Head Division; Sorensen, Daniel N. [Naval Surface Warfare Center (NSWC), Indian Head, MD (United States). Indian Head Division; Remmers, Daniel L. [Naval Surface Warfare Center (NSWC), Indian Head, MD (United States). Indian Head Division; Phillips, Jason J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Shelley, Timothy J. [Air Force Research Lab. (AFRL), Tyndall AFB, FL (United States); Reyes, Jose A. [Applied Research Associates, Tyndall AFB, FL (United States); Hsu, Peter C. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Reynolds, John G. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2015-10-30

    The Integrated Data Collection Analysis (IDCA) program is conducting a Proficiency Test for Small- Scale Safety and Thermal (SSST) testing of homemade explosives (HMEs). Described here are statistical analyses of the results for impact, friction, electrostatic discharge, and differential scanning calorimetry analysis of the RDX Type II Class 5 standard. The material was tested as a well-characterized standard several times during the proficiency study to assess differences among participants and the range of results that may arise for well-behaved explosive materials. The analyses show that there are detectable differences among the results from IDCA participants. While these differences are statistically significant, most of them can be disregarded for comparison purposes to assess potential variability when laboratories attempt to measure identical samples using methods assumed to be nominally the same. The results presented in this report include the average sensitivity results for the IDCA participants and the ranges of values obtained. The ranges represent variation about the mean values of the tests of between 26% and 42%. The magnitude of this variation is attributed to differences in operator, method, and environment as well as the use of different instruments that are also of varying age. The results appear to be a good representation of the broader safety testing community based on the range of methods, instruments, and environments included in the IDCA Proficiency Test.

  16. The virtual analyst program: automated data mining, error analysis, and reporting

    Science.gov (United States)

    W. Keith Moser; Mark H. Hansen; Patrick Miles; Ronald E. McRoberts

    2007-01-01

    The Forest Inventory and Analysis (FIA) program of the U.S. Department of Agriculture Forest Service conducts ongoing comprehensive inventories of the forest resources of the United States. The Northern Region FIA (NFIA) program has three tasks: (1) core reporting function, which produces the annual and 5-year inventory reports; (2) forest health measurements; and (3)...

  17. Parent Training Programs for Ethnic Minorities: a Meta-analysis of Adaptations and Effect

    NARCIS (Netherlands)

    Mourik, K. van; Crone, M.R.; Wolff, M.S. de; Reis, R.

    2016-01-01

    This meta-analysis focuses on parent training programs for ethnic minority families and reports on (i) the adaptation of program content and (ii) the process that informs these adaptations. Relevant studies are reviewed to determine the adaptations made and the impact of the adaptations on parenting

  18. Vermont's use-value appraisal property tax program: a forest inventory and analysis

    Science.gov (United States)

    Paul E. Sendak; Donald F. Dennis; Donald F. Dennis

    1989-01-01

    A statistical report and analysis of the timberland enrolled in the Vermont Use Value Appraisal (UVA) property tax program. The study was conducted using data collected in the fourth forest survey of Vermont (1983). Estimates are presented on land area, timber volumes, tree quality, numbers of live trees, and biomass for timberland enrolled in the UVA program and for...

  19. Cartographic standards to improve maps produced by the Forest Inventory and Analysis program

    Science.gov (United States)

    Charles H. (Hobie) Perry; Mark D. Nelson

    2009-01-01

    The Forest Service, U.S. Department of Agriculture's Forest Inventory and Analysis (FIA) program is incorporating an increasing number of cartographic products in reports, publications, and presentations. To create greater quality and consistency within the national FIA program, a Geospatial Standards team developed cartographic design standards for FIA map...

  20. An Analysis of Homeless Veterans Participating in the Homeless Veteran Reintegration Program

    Science.gov (United States)

    Campbell, Katrina Lanelle

    2010-01-01

    The purpose of this study was to conduct an analysis on ex post facto data of the federal grant supported Homeless Veterans Reintegration Program (HVRP) administered at Goodwill Industries of Lower South Carolina. Pre-existing data on variables such as performance goals, training activities, support services, and demographics from program years…

  1. 75 FR 78798 - Airport Improvement Program: Proposed Changes to Benefit Cost Analysis (BCA) Threshold

    Science.gov (United States)

    2010-12-16

    ... Federal Aviation Administration Airport Improvement Program: Proposed Changes to Benefit Cost Analysis... requiring benefit cost analyses (BCA) for capacity projects when applying for Airport Improvement Program... Friday, except Federal holidays. Privacy: We will post all comments we receive, without change, to http...

  2. Micosoft Excel Sensitivity Analysis for Linear and Stochastic Program Feed Formulation

    Science.gov (United States)

    Sensitivity analysis is a part of mathematical programming solutions and is used in making nutritional and economic decisions for a given feed formulation problem. The terms, shadow price and reduced cost, are familiar linear program (LP) terms to feed formulators. Because of the nonlinear nature of...

  3. Self-evaluation of assessment programs: A cross-case analysis

    NARCIS (Netherlands)

    Baartman, Liesbeth; Prins, Frans; Kirschner, Paul A.; Van der Vleuten, Cees

    2011-01-01

    Baartman, L. K. J., Prins, F. J., Kirschner, P. A., & Van der Vleuten, C. P. M. (2011). Self-evaluation of assessment programs: A cross-case analysis. Evaluation and Program Planning, 34, 206-216. doi: 10.1016/j.evalprogplan.2011.03.001

  4. Effectiveness of the Triple P Positive Parenting Program on Parenting: A Meta-Analysis

    Science.gov (United States)

    de Graaf, Ireen; Speetjens, Paula; Smit, Filip; de Wolff, Marianne; Tavecchio, Louis

    2008-01-01

    Triple P is a parenting program intended to prevent and to provide treatment for severe behavioral, emotional, and developmental problems in children. The aim of this meta-analysis was to assess the effectiveness of Triple P Level 4 interventions on parenting styles and parental competency. Level 4 is an intensive training program of 8-10 sessions…

  5. Sensitivity analysis of linear programming problem through a recurrent neural network

    Science.gov (United States)

    Das, Raja

    2017-11-01

    In this paper we study the recurrent neural network for solving linear programming problems. To achieve optimality in accuracy and also in computational effort, an algorithm is presented. We investigate the sensitivity analysis of linear programming problem through the neural network. A detailed example is also presented to demonstrate the performance of the recurrent neural network.

  6. A Cost-Savings Analysis of a Statewide Parenting Education Program in Child Welfare

    Science.gov (United States)

    Maher, Erin J.; Corwin, Tyler W.; Hodnett, Rhenda; Faulk, Karen

    2012-01-01

    Objectives: This article presents a cost-savings analysis of the statewide implementation of an evidence-informed parenting education program. Methods: Between the years 2005 and 2008, the state of Louisiana used the Nurturing Parenting Program (NPP) to impart parenting skills to child welfare-involved families. Following these families' outcomes…

  7. Program-specific cost-effectiveness analysis: breast cancer screening policies for a safety-net program.

    Science.gov (United States)

    Melnikow, Joy; Tancredi, Daniel J; Yang, Zhuo; Ritley, Dominique; Jiang, Yun; Slee, Christina; Popova, Svetlana; Rylett, Phillip; Knutson, Kirsten; Smalley, Sherie

    2013-01-01

    Every Woman Counts (EWC), a California breast cancer screening program, faced challenging budget cutbacks and policy choices. A microsimulation model evaluated costs, outcomes, and cost-effectiveness of EWC program mammography policy options on coverage for digital mammography (which has a higher cost than film mammography but recent legislation allowed reimbursement at the lower film rate); screening eligibility age; and screening frequency. Model inputs were based on analyses of program claims data linked to California Cancer Registry data, Surveillance, Epidemiology, and End Results data, and the Medi-Cal literature. Outcomes included number of procedures, cancers, cancer deaths, costs, and incremental cost per life-year. Projected model outcomes matched program data closely. With restrictions on the number of clients screened, strategies starting screening at age 40 years were dominated (not cost-effective). This finding was highly robust in sensitivity analyses. Compared with no screening, biennial film mammography for women aged 50 to 64 years was projected to reduce 15-year breast cancer mortality by nearly 7.8% at $18,999 per additional life-year, annual film mammography was $106,428 per additional life-year, and digital mammography $180,333 per additional life-year. This more effective, more expensive strategy was projected to reduce breast cancer mortality by 8.6%. Under equal mammography reimbursement, biennial digital mammography beginning at age 50 years was projected to decrease 15-year breast cancer mortality by 8.6% at an incremental cost per additional life-year of $17,050. For the EWC program, biennial screening mammography starting at age 50 years was the most cost-effective strategy. The impact of digital mammography on life expectancy was small. Program-specific cost-effectiveness analysis can be completed in a policy-relevant time frame to assist policymakers faced with difficult program choices. Copyright © 2013, International Society for

  8. Using SWOT Analysis for Promoting the Accounting Program.

    Science.gov (United States)

    Sawyer, Joe E.

    2001-01-01

    Describes how SWOT (strengths, weaknesses, opportunities, threats) analysis can be used by business educators to find the best match between environmental trends (opportunities and threats) and internal departmental capabilities (strengths and weaknesses). An example from accounting education is provided. (JOW)

  9. Usability Analysis of the Channel Application Programming Interface

    National Research Council Canada - National Science Library

    Brown, Christopher

    2003-01-01

    ... has ever used the API; hence, no analysis was accomplished with respect to usability attributes, The project sponsor desires public release of the API, especially within the Department of Defense (DoD...

  10. Analisis Efektivitas Perangkat pada Program Desa Broadband Terpadu [Analysis of Device Effectiveness in Integrated Broadband Village Program

    Directory of Open Access Journals (Sweden)

    Hilarion Hamjen

    2016-12-01

    Full Text Available Pemerintah berkomitmen mendukung pertumbuhan e-commerce dan ekonomi digital di Indonesia untuk mencapai visi Indonesia 2020 sebagai negara ekonomi digital terbesar di Asia Tenggara. Secara fundamental diperlukan dukungan konektivitas nasional dari tingkat pusat sampai ke tingkat lokal, salah satunya melalui program KPU/USO yaitu program DBT (Desa Broadband Terpadu. Penelitian ini bertujuan untuk mengetahui efektivitas perangkat pada program DBT phase 1 dan keterkaitannya dengan konektivitas, dengan menggunakan metode analisis kepentingan kinerja dan uji statistik Chi square. Berdasarkan hasil penelitian diketahui bahwa efektivitas perangkat meliputi variabel kondisi, fungsi, pemeliharaan dan pemanfaatan rata-rata adalah 84,5 persen. Dengan nilai efektivitas tersebut diketahui bahwa keseluruhan variabel kondisi perangkat, fungsi dan pemanfaatannya tidak mempengaruhi konektivitas.  *****The Indonesian government has a strong commitment in supporting the growth of e-commerce and Digital Economy in Indonesia to attain Indonesia’s vision by 2020 as the largest digital economy nation in Southeast Asia. Fundamentally, the national connectivity supports from central level to local level are needed, where one of them comes from Integrated Broadband Village program. This research determines the effectiveness of devices in the DBT program and its correlation to the connectivity, by using importance-performance analysis method and Chi-square statistical test. It is known from the result that the effectiveness of devices, including condition, function, maintenance, and utilization variables, achieves 84.5 percent on average. The value shows that all mentioned variables have insignificant correlations to the connectivity.

  11. Cost benefit analysis of the California HVS program

    CSIR Research Space (South Africa)

    Du Plessis, L

    2008-10-01

    Full Text Available ); • Compile a set of assumptions required for a benefit/cost analysis including analysis period, initial construction costs, routine maintenance costs, rehabilitation timing and costs, discount rate etc.; • Conduct initial benefit/cost analyses based... Pf Ca Cb Cc Concrete Base Pavement Notation: Pi = Probability that option I would be implemented Ci = Discounted life cycle cost for each alternative Asphalt Base Pavement G1 Base Pavement Effective cost for each alternative = (P i ) x (C i...

  12. The breeding of programs for short-term ionospheric analysis

    Science.gov (United States)

    Telfer, C. R.

    The Darwinian 'survival of the fittest' principle is presently embodied in a process for computer-program definition and applied to the development of a code for short-term forecasting of the ionospheric parameter foF2. The code, in a manner analogous to biological populations, is structured according to 'beasts' and 'herds' whose genealogies and 'genetic variability' (mutation rate) are of central importance. The investigation, which draws on the three disciplines of computation, telecommunications, and biological evolution, has relevance for each.

  13. Marine Ecosystems Analysis (MESA) Program, New York Bight Surficial Sediment Analyses

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The Marine Ecosystems Analysis (MESA) Program, New York Bight Study was funded by NOAA and the Bureau of Land Management (BLM). The Atlas was a historical...

  14. Coastal Change Analysis Program (C-CAP) Regional Land Cover Data and Change Data

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NOAA Coastal Change Analysis Program (C-CAP) produces national standardized land cover and change products for the coastal regions of the U.S. C-CAP products...

  15. NOAA's Coastal Change Analysis Program (C-CAP) 2001 Regional Land Cover Data - Coastal United States

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NOAA Coastal Change Analysis Program (C-CAP) produces national standardized land cover and change products for the coastal regions of the U.S. C-CAP products...

  16. NOAA's Coastal Change Analysis Program (C-CAP) 1985 Regional Land Cover Data - Coastal United States

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NOAA Coastal Change Analysis Program (C-CAP) produces national standardized land cover and change products for the coastal regions of the U.S. C-CAP products...

  17. Intraobserver and intermethod reliability for using two different computer programs in preoperative lower limb alignment analysis

    Directory of Open Access Journals (Sweden)

    Mohamed Kenawey

    2016-12-01

    Conclusion: Computer assisted lower limb alignment analysis is reliable whether using graphics editing program or specialized planning software. However slight higher variability for angles away from the knee joint can be expected.

  18. NOAA's Coastal Change Analysis Program (C-CAP) 2006 Regional Land Cover Data - Coastal United States

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NOAA Coastal Change Analysis Program (C-CAP) produces national standardized land cover and change products for the coastal regions of the U.S. C-CAP products...

  19. NOAA's Coastal Change Analysis Program (C-CAP) 1996 Regional Land Cover Data - Coastal United States

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NOAA Coastal Change Analysis Program (C-CAP) produces national standardized land cover and change products for the coastal regions of the U.S. C-CAP products...

  20. NOAA's Coastal Change Analysis Program (C-CAP) 2010 Regional Land Cover Data - Coastal United States

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NOAA Coastal Change Analysis Program (C-CAP) produces national standardized land cover and change products for the coastal regions of the U.S. C-CAP products...

  1. NOAA's Coastal Change Analysis Program (C-CAP) 1975 Regional Land Cover Data - Coastal United States

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NOAA Coastal Change Analysis Program (C-CAP) produces national standardized land cover and change products for the coastal regions of the U.S. C-CAP products...

  2. NOAA's Coastal Change Analysis Program (C-CAP) 1996 Forest Fragmentation Data - Coastal United States

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NOAA Coastal Change Analysis Program (C-CAP) produces national standardized land cover and change products for the coastal regions of the U.S. C-CAP products...

  3. NOAA's Coastal Change Analysis Program (C-CAP) 2001 Forest Fragmentation Data - Coastal United States

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NOAA Coastal Change Analysis Program (C-CAP) produces national standardized land cover and change products for the coastal regions of the U.S. C-CAP products...

  4. NOAA's Coastal Change Analysis Program (C-CAP) 2010 Forest Fragmentation Data - Coastal United States

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NOAA Coastal Change Analysis Program (C-CAP) produces national standardized land cover and change products for the coastal regions of the U.S. C-CAP products...

  5. NOAA's Coastal Change Analysis Program (C-CAP) 1992 Forest Fragmentation Data - Coastal United States

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NOAA Coastal Change Analysis Program (C-CAP) produces national standardized land cover and change products for the coastal regions of the U.S. C-CAP products...

  6. A CRITICAL MULTICULTURAL ANALYSIS OF A ROMANIAN TEXTBOOK TAUGHT IN ELEMENTARY INTERNATIONAL LANGUAGE PROGRAMS

    National Research Council Canada - National Science Library

    Dorian Stoilescu

    2014-01-01

      This case study proposes a critical multicultural analysis of a Romanian language textbook used for instructing students in grades one and two in the Elementary Language International Program (ELIP...

  7. Articulation Therapy Using Distinctive Feature Analysis to Structure the Training Program: Two Case Studies.

    Science.gov (United States)

    Ruder, Kenneth F.; Bunce, Betty H.

    1981-01-01

    Two case reports of 4 and 5 year old children describe the rationale and procedures for structuring an articulation therapy program on the basis of distinctive feature analysis of the child's articulation problems. (Author/DB)

  8. NOAA's Coastal Change Analysis Program (C-CAP) 2006 Forest Fragmentation Data - Coastal United States

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NOAA Coastal Change Analysis Program (C-CAP) produces national standardized land cover and change products for the coastal regions of the U.S. C-CAP products...

  9. NOAA's Coastal Change Analysis Program (C-CAP) 1985 Forest Fragmentation Data - Coastal United States

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NOAA Coastal Change Analysis Program (C-CAP) produces national standardized land cover and change products for the coastal regions of the U.S. C-CAP products...

  10. NOAA's Coastal Change Analysis Program (C-CAP) 2016 Regional Land Cover Data - Coastal United States

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NOAA Coastal Change Analysis Program (C-CAP) produces national standardized land cover and change products for the coastal regions of the U.S. C-CAP products...

  11. Coastal Change Analysis Program (C-CAP) High Resolution Land Cover and Change Data

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — The NOAA Coastal Change Analysis Program (C-CAP) produces national standardized high resolution land cover and change products for the coastal regions of the U.S....

  12. Precise Analysis of Array Usage in Scientific Programs

    Directory of Open Access Journals (Sweden)

    M. Manjunathaiah

    1997-01-01

    Full Text Available The automatic transformation of sequential programs for efficient execution on parallel computers involves a number of analyses and restructurings of the input. Some of these analyses are based on computing array sections, a compact description of a range of array elements. Array sections describe the set of array elements that are either read or written by program statements. These sections can be compactly represented using shape descriptors such as regular sections, simple sections, or generalized convex regions. However, binary operations such as Union performed on these representations do not satisfy a straightforward closure property, e.g., if the operands to Union are convex, the result may be nonconvex. Approximations are resorted to in order to satisfy this closure property. These approximations introduce imprecision in the analyses and, furthermore, the imprecisions resulting from successive operations have a cumulative effect. Delayed merging is a technique suggested and used in some of the existing analyses to minimize the effects of approximation. However, this technique does not guarantee an exact solution in a general setting. This article presents a generalized technique to precisely compute Union which can overcome these imprecisions.

  13. [Cost-effectiveness analysis on colorectal cancer screening program].

    Science.gov (United States)

    Huang, Q C; Ye, D; Jiang, X Y; Li, Q L; Yao, K Y; Wang, J B; Jin, M J; Chen, K

    2017-01-10

    Objective: To evaluate the cost-effectiveness of colorectal cancer screening program in different age groups from the view of health economics. Methods: The screening compliance rates, detection rates in different age groups were calculated by using the data from colorectal cancer screening program in Jiashan county, Zhejiang province. The differences in indicator among age groups were analyzed with χ(2) test or trend χ(2) test. The ratios of cost to the number of case were calculated according to cost statistics. Results: The detection rates of immunochemical fecal occult blood test (iFOBT) positivity, advanced adenoma and colorectal cancer and early stage cancer increased with age, while the early diagnosis rates were negatively associated with age. After exclusion the younger counterpart, the cost-effectiveness of individuals aged >50 years could be reduced by 15%-30%. Conclusion: From health economic perspective, it is beneficial to start colorectal cancer screening at age of 50 years to improve the efficiency of the screening.

  14. The R software fundamentals of programming and statistical analysis

    CERN Document Server

    Lafaye de Micheaux, Pierre; Liquet, Benoit

    2013-01-01

    The contents of The R Software are presented so as to be both comprehensive and easy for the reader to use. Besides its application as a self-learning text, this book can support lectures on R at any level from beginner to advanced. This book can serve as a textbook on R for beginners as well as more advanced users, working on Windows, MacOs or Linux OSes. The first part of the book deals with the heart of the R language and its fundamental concepts, including data organization, import and export, various manipulations, documentation, plots, programming and maintenance.  The last chapter in this part deals with oriented object programming as well as interfacing R with C/C++ or Fortran, and contains a section on debugging techniques. This is followed by the second part of the book, which provides detailed explanations on how to perform many standard statistical analyses, mainly in the Biostatistics field. Topics from mathematical and statistical settings that are included are matrix operations, integration, o...

  15. Techniques to improve testing scalability on concurrent programs: combining static analysis and testing for Deadlock detection

    OpenAIRE

    Isabel Márquez, Miguel

    2015-01-01

    Static deadlock analyzers might be able to verify the absence of deadlock, but when they detect a potential deadlock cycle, they provide little (or even none) information on their output. Due to the complex ow of concurrent programs, the user might not be able to find the source of the anomalous behaviour from the abstract information computed by static analysis.This paper proposes the combined use of static analysis and testing for effective deadlock detection in asynchronous programs. Our m...

  16. A new computer program for QSAR-analysis: ARTE-QSAR.

    Science.gov (United States)

    Van Damme, Sofie; Bultinck, Patrick

    2007-08-01

    A new computer program has been designed to build and analyze quantitative-structure activity relationship (QSAR) models through regression analysis. The user is provided with a range of regression and validation techniques. The emphasis of the program lies mainly in the validation of QSAR models in chemical applications. ARTE-QSAR produces an easy interpretable output from which the user can conclude if the obtained model is suitable for prediction and analysis.

  17. Statistics and quality assurance for the Northern Research Station Forest Inventory and Analysis Program

    Science.gov (United States)

    Dale D. Gormanson; Scott A. Pugh; Charles J. Barnett; Patrick D. Miles; Randall S. Morin; Paul A. Sowers; James A. Westfall

    2018-01-01

    The U.S. Forest Service Forest Inventory and Analysis (FIA) program collects sample plot data on all forest ownerships across the United States. FIA’s primary objective is to determine the extent, condition, volume, growth, and use of trees on the Nation’s forest land through a comprehensive inventory and analysis of the Nation’s forest resources. The FIA program...

  18. Developing a quality assurance program for gunshot primer residue analysis

    Science.gov (United States)

    White, Thomas R.

    2014-09-01

    The Texas DPS Crime Laboratory Service analyzes an average of 45 gunshot residue (GSR) kits a month using three different SEM/EDS systems and involving four different analysts. To maintain the volume of cases, we have developed a robust, cost-efficient method to ensure that all three systems are performing automated GSR analysis within laboratory specifications, and yielding consistent results across all three systems. This analysis commonly includes analysis of GSR kits collected from suspects' hands, but can also include kits from screening of suspects' clothing for GSR. Analysts have developed procedures for cleaning and monitoring areas where clothing and GSR stubs are processed and analyzed in order to ensure that casework stubs were not contaminated in the laboratory.

  19. Analysis of amino acid composition in proteins of animal tissues and foods as pre-column o-phthaldialdehyde derivatives by HPLC with fluorescence detection.

    Science.gov (United States)

    Dai, Zhaolai; Wu, Zhenlong; Jia, Sichao; Wu, Guoyao

    2014-08-01

    Studies of protein nutrition and biochemistry require reliable methods for analysis of amino acid (AA) composition in polypeptides of animal tissues and foods. Proteins are hydrolyzed by 6M HCl (110°C for 24h), 4.2M NaOH (105°C for 20 h), or proteases. Analytical techniques that require high-performance liquid chromatography (HPLC) include pre-column derivatization with 4-chloro-7-nitrobenzofurazan, 9-fluorenyl methylchloroformate, phenylisothiocyanate, naphthalene-2,3-dicarboxaldehyde, 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate, and o-phthaldialdehyde (OPA). OPA reacts with primary AA (except cysteine or cystine) in the presence of 2-mercaptoethanol or 3-mercaptopropionic acid to form a highly fluorescent adduct. OPA also reacts with 4-amino-1-butanol and 4-aminobutane-1,3-diol produced from oxidation of proline and 4-hydroxyproline, respectively, in the presence of chloramine-T plus sodium borohydride at 60°C, or with S-carboxymethyl-cysteine formed from cysteine and iodoacetic acid at 25°C. Fluorescence of OPA derivatives is monitored at excitation and emission wavelengths of 340 and 455 nm, respectively. Detection limits are 50 fmol for AA. This technique offers the following advantages: simple procedures for preparation of samples, reagents, and mobile-phase solutions; rapid pre-column formation of OPA-AA derivatives and their efficient separation at room temperature (e.g., 20-25°C); high sensitivity of detection; easy automation on the HPLC apparatus; few interfering side reactions; a stable chromatography baseline for accurate integration of peak areas; and rapid regeneration of guard and analytical columns. Thus, the OPA method provides a useful tool to determine AA composition in proteins of animal tissues (e.g., skeletal muscle, liver, intestine, placenta, brain, and body homogenates) and foods (e.g., milk, corn grain, meat, and soybean meal). Copyright © 2014 Elsevier B.V. All rights reserved.

  20. F-Chart handbook. Active solar system sizing and economic analysis program

    Science.gov (United States)

    Mielke, G. W.

    1981-04-01

    The program is applicable to active solar space and service water heating systems that incorporate typical flat-plate solar collectors. The program is based on the F-Chart method of estimating annual system thermal performance. This program uses a standard life-cycle cost analysis methodology to calculate optimum solar system size and present economic performance data. The F-Chart program is designed to be used by anyone interested in, or involved with, solar heating systems. This handbook describes both information input requirements and the resultant thermal and economic analyses.

  1. NASA's Upper Atmosphere Research Program (UARP) and Atmospheric Chemistry Modeling and Analysis Program (ACMAP): Research Summaries 1997-1999

    Science.gov (United States)

    Kurylo, M. J.; DeCola, P. L.; Kaye, J. A.

    2000-01-01

    Under the mandate contained in the FY 1976 NASA Authorization Act, the National Aeronautics and Space Administration (NASA) has developed and is implementing a comprehensive program of research, technology development, and monitoring of the Earth's upper atmosphere, with emphasis on the upper troposphere and stratosphere. This program aims at expanding our chemical and physical understanding to permit both the quantitative analysis of current perturbations as well as the assessment of possible future changes in this important region of our environment. It is carried out jointly by the Upper Atmosphere Research Program (UARP) and the Atmospheric Chemistry Modeling and Analysis Program (ACMAP), both managed within the Research Division in the Office of Earth Science at NASA. Significant contributions to this effort have also been provided by the Atmospheric Effects of Aviation Project (AEAP) of NASA's Office of Aero-Space Technology. The long-term objectives of the present program are to perform research to: understand the physics, chemistry, and transport processes of the upper troposphere and the stratosphere and their control on the distribution of atmospheric chemical species such as ozone; assess possible perturbations to the composition of the atmosphere caused by human activities and natural phenomena (with a specific emphasis on trace gas geographical distributions, sources, and sinks and the role of trace gases in defining the chemical composition of the upper atmosphere); understand the processes affecting the distributions of radiatively active species in the atmosphere, and the importance of chemical-radiative-dynamical feedbacks on the meteorology and climatology of the stratosphere and troposphere; and understand ozone production, loss, and recovery in an atmosphere with increasing abundances of greenhouse gases. The current report is composed of two parts. Part 1 summarizes the objectives, status, and accomplishments of the research tasks supported

  2. SSL Pricing and Efficacy Trend Analysis for Utility Program Planning

    Energy Technology Data Exchange (ETDEWEB)

    Tuenge, Jason R.

    2013-10-01

    An LED lamp or luminaire can generally be found that matches or exceeds the efficacy of benchmark technologies in a given product category, and LED products continue to expand into ever-higher lumen output niches. However, the price premium for LED continues to pose a barrier to adoption in many applications, in spite of expected savings from reduced energy use and maintenance. Other factors—such as dimmability and quality of light—can also present challenges. The appropriate type, timing, and magnitude of energy efficiency activities will vary from organization to organization based on local variables and the method of evaluation. A number of factors merit consideration when prioritizing activities for development. Category-specific projections for pricing and efficacy are provided herein to assist in efficiency program planning efforts.

  3. The JUPITER-III Program: ANL analysis of ZPPR-17

    Energy Technology Data Exchange (ETDEWEB)

    Brumbach, S.B.; Collins, P.J.; Grasseschi, G.L.; Schaefer, R.W.; Brumbach, S.B.; Collins, P.J.; Grasseschi, G.L.; Schaefer, R.W.

    1989-01-31

    The ZPPR-17 assembly was part of the JUPITER-III cooperative program between the US DOE and PNC of Japan. The assembly was designed to study the neutronic behavior of a large, axially heterogeneous, liquid-metal-cooled reactor. The unique feature of the assembly was an internal blanket region in the axial center of the core extending two-thirds of the core radius. Assembly variants with 25 control rod positions and with 13 half-inserted control rods were built. This report describes in detail the results of measurements and analyses of ZPPR-17. The measurements emphasized reaction rate distributions, and gamma dose measurements were included. Additional measurements were control worth, sodium void worth, and reactivity coefficients associated with small material motions in assembly expansion and bowing.

  4. Design and Analysis of Decision Rules via Dynamic Programming

    KAUST Repository

    Amin, Talha M.

    2017-04-24

    The areas of machine learning, data mining, and knowledge representation have many different formats used to represent information. Decision rules, amongst these formats, are the most expressive and easily-understood by humans. In this thesis, we use dynamic programming to design decision rules and analyze them. The use of dynamic programming allows us to work with decision rules in ways that were previously only possible for brute force methods. Our algorithms allow us to describe the set of all rules for a given decision table. Further, we can perform multi-stage optimization by repeatedly reducing this set to only contain rules that are optimal with respect to selected criteria. One way that we apply this study is to generate small systems with short rules by simulating a greedy algorithm for the set cover problem. We also compare maximum path lengths (depth) of deterministic and non-deterministic decision trees (a non-deterministic decision tree is effectively a complete system of decision rules) with regards to Boolean functions. Another area of advancement is the presentation of algorithms for constructing Pareto optimal points for rules and rule systems. This allows us to study the existence of “totally optimal” decision rules (rules that are simultaneously optimal with regards to multiple criteria). We also utilize Pareto optimal points to compare and rate greedy heuristics with regards to two criteria at once. Another application of Pareto optimal points is the study of trade-offs between cost and uncertainty which allows us to find reasonable systems of decision rules that strike a balance between length and accuracy.

  5. Biomass energy production in agriculture: A weighted goal programming analysis

    Energy Technology Data Exchange (ETDEWEB)

    Ballarin, A. [TeSAF, Department of Land, Environment, Agriculture and Forestry, University of Padova (Italy); Vecchiato, D., E-mail: daniel.vecchiato@unipd.i [TeSAF, Department of Land, Environment, Agriculture and Forestry, University of Padova (Italy); Tempesta, T. [TeSAF, Department of Land, Environment, Agriculture and Forestry, University of Padova (Italy); Marangon, F.; Troiano, S. [DSE, Department of Economic Sciences, University of Udine (Italy)

    2011-03-15

    Energy production from biomasses can be an important resource that, when combined with other green energies such as wind power and solar plants, can contribute to reduce dependency on fossil fuels. The aim of this study is to assess how agriculture could contribute to the production of bio-energy. A multi-period Weighted Goal Programming model (MpWGP) has been applied to identify the optimal land use combinations that simultaneously maximise farmers' income and biomass energy production under three concurrent constraints: water, labour and soil availability. Alternative scenarios are considered that take into account the effect of climate change and social change. The MpWGP model was tested with data from the Rovigo county area (Italy) over a 15-year time period. Our findings show that trade-off exists between the two optimisation targets considered. Although the optimisation of the first target requires traditional agricultural crops, which are characterised by high revenue and a low production of biomass energy, the latter would be achievable with intensive wood production, namely, high-energy production and low income. Our results also show the importance of the constraints imposed, particularly water availability; water scarcity has an overall negative effect and specifically affects the level of energy production. - Research Highlights: {yields} The aim of this study is to assess how agriculture could contribute to the production of bio-energy. {yields} A multi-period (15-year) Weighted Goal Programming model (MpWGP) has been applied. {yields} We identify the optimal land use combinations that simultaneously maximise farmers' income and biomass energy production. {yields} Three concurrent constraints have been considered: water, labour and soil availability.{yields} Water scarcity has an overall negative effect and specifically affects the level of energy production.

  6. An Empirical Analysis of Factors Affecting Honors Program Completion Rates

    Science.gov (United States)

    Savage, Hallie; Raehsler, Rod D.; Fiedor, Joseph

    2014-01-01

    One of the most important issues in any educational environment is identifying factors that promote academic success. A plethora of research on such factors exists across most academic fields, involving a wide range of student demographics, and the definition of student success varies across the range of studies published. The analysis in this…

  7. Content Analysis Schedule for Bilingual Education Programs: Proyecto PAL.

    Science.gov (United States)

    Gonzalez, Castor

    This content analysis schedule for "Proyecto PAL" in San Jose, California, presents information on the history, funding, and scope of the project. Included are sociolinguistic process variables such as the native and dominant languages of students and their interaction. Information is provided on staff selection and the linguistic…

  8. Proceedings of the first analysis meeting on JUPITER-II Program

    Energy Technology Data Exchange (ETDEWEB)

    Shiradata, Keisho; Yamamoto, Masaaki [comps.

    1984-12-31

    The JUPITER-II Program is the Joint Physics Large Heterogeneous Core Critical Experiments Program between the U.S. Department of Energy (US DOE) and PNC, Japan. The experiments began in May 1982 and ended in April 1984, as a part of the ZPPR-13 program. The ZPPR-13 is a series of critical assemblies designed to study the fundamental neutronic behavior of large, radially-heterogeneous LMFBR cores. This report describes the results of analysis of ZPPR-13A and preliminary analysis of ZPPR-13B, and some topics of recent activities in fast reactor physics.

  9. PLATO A Program Library for the Analysis of 4D Nonlinear Transverse Motion

    CERN Document Server

    Giovannozzi, Massimo; Bazzani, A; Bartolini, R

    1998-01-01

    The PLATO (Perturbative Lattice Analysis and Tracking tOols) program, a program library for analyzing four-dimensional betatronic motion in circular particle accelerators is presented. The routines included in this library provide both the resonant and the nonresonant perturbative series that approximate nonlinear motion (normal forms); standard numerical tools such as the Lyapunov exponent, frequency analysis and evaluation of the dynamic aperture are also available. To ensure the highest flexibility, the code is fully compatible with standard tracking programs commonly used in the accelerator physics community.

  10. Utilization of Concept Mapping Program at the Root Cause Analysis of Events

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Bae-Joo; Kim, Gwang-Bong [Nuclear Power Education Institute, Ulsan (Korea, Republic of)

    2008-05-15

    KHNP introduced the Corrective Action Program (CAP) as a part of the nuclear operation innovation. The Key program of the CAP is the Root Cause Analysis (RCA) program. The RCA is a technique to extract root causes and take actions to prevent a recurrence in the event that management doesn't want it to happen again. KHNP establishes a temporary team for RCA of some event. KHNP should assign some human resources to the temporary team. KNPEI introduced a RCA training program from Comanche Peak Steam Electric Station in 2005 and began training the engineers from 2006. But the RCA Program doesn't operate well at the stations because of two reasons. KNPEI performed a research project from March 2006 to September 2007 to capture experience knowledge from seniors and transfer it to juniors. As part of the research activity KNPEI introduced a Concept Mapping Program and set up a Concept Mapping server to capture experience knowledge. Originally, the Concept Mapping Program was to teach conceptual knowledge by remote. But this Concept Mapping Program has some characteristics that can be used in root causes analysis. The purpose of this report is to suggest the utilization method in root causes analysis in the Concept Mapping.

  11. Integrated Data Collection Analysis (IDCA) Program — IDCA Quarterly Program Review, September 14 and 15, 2010

    Energy Technology Data Exchange (ETDEWEB)

    Sandstrom, Mary M. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Brown, Geoffrey W. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Warner, Kirstin F. [Naval Surface Warfare Center (IHD-NSWC), Indian Head, MD (United States). Indian Head Division; Remmers, Daniel L. [Naval Surface Warfare Center (IHD-NSWC), Indian Head, MD (United States). Indian Head Division; Shelley, Timothy J. [Air Force Research Lab. (AFRL/RXQF), Tyndall AFB, FL (United States); Reyes, Jose A. [Applied Research Associates, Inc., Tyndall AFB, FL (United States); Hsu, Peter C. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Reynolds, John G. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2012-02-07

    The IDCA conducted a program review at Los Alamos National Laboratory, September 14 and 15, 2010. The review was divided into three parts: 1) an update on the current status of the program, 2) an information exchange and discussion on technical details for current issues and future planning, and 3) a tour of the SSST testing facilities at LANL. The meeting started with an update from DHS by Laura Parker and a restating of some of the objectives of the Proficiency Test of which the IDCA is currently engaged. This update was followed by a discussion of some high level programmatic issues particularly about ways of communicating the overall goals of the IDCA to non-technical representatives. The final topic focused on the difficulty of releasing information, including the DHS approval process, ITAR, and open publication. Next JGR presented a technical summary of accomplishments, schedule, milestones, and future directions. These key points made were: 1) about 1/3 of the materials have been tested, 2) some participants are behind others causing a lag in report writing, 3) method reports have been assigned to various participants to speed up the process of reporting, 4) the SSST Compendium needs reformatting and restructuring, and 5) the Compendium needs a web site to house with access control. After the technical update, some of the Proficiency Test results were shown comparing data from the various laboratories. These results included comparisons of the RDX standard, KC/sugar mixtures (-100 mesh and as received), KC/dodecane, KP/Al, and KP/C. Impact, friction, ESD, and DSC results were the focus. All the participants were involved in these discussions. This report includes summary notes, presentations, and explanatory information.

  12. A novel patient support program to address isotretinoin adherence: proof-of-concept analysis.

    Science.gov (United States)

    Eichenfield, Lawrence F; Krakowski, Andrew C

    2015-04-01

    The iPLEDGE protocol for isotretinoin treatment requires multiple steps to be completed within strict timing windows, resulting in many interruptions or discontinuations of treatment. The US Food and Drug Administration has indicated that approximately 40% of isotretinoin prescriptions written over the course of one year of the iPLEDGE program were denied due to failure to comply with iPLEDGE. Insurance restrictions add to the likelihood of prescriptions not being filled. Here, we describe a novel program implemented specifically to assist patients and providers with improving isotretinoin therapy adherence. This innovative isotretinoin support program provides assistance with insurance questions and hurdles, an uninterrupted treatment supply, educational support, reminder communications, and an indigent patient assistance program. Proof-of-concept analysis shows that 17 months after implementation of the program, 93% of prescriptions received have been filled. Utilization of the program appears to improve adherence to an isotretinoin treatment regimen, with fewer interruptions due directly to unfilled prescriptions.

  13. TCP/IP Interface for the Satellite Orbit Analysis Program (SOAP)

    Science.gov (United States)

    Carnright, Robert; Stodden, David; Coggi, John

    2009-01-01

    The Transmission Control Protocol/ Internet protocol (TCP/IP) interface for the Satellite Orbit Analysis Program (SOAP) provides the means for the software to establish real-time interfaces with other software. Such interfaces can operate between two programs, either on the same computer or on different computers joined by a network. The SOAP TCP/IP module employs a client/server interface where SOAP is the server and other applications can be clients. Real-time interfaces between software offer a number of advantages over embedding all of the common functionality within a single program. One advantage is that they allow each program to divide the computation labor between processors or computers running the separate applications. Secondly, each program can be allowed to provide its own expertise domain with other programs able to use this expertise.

  14. Causal Analysis for Performance Modeling of Computer Programs

    Directory of Open Access Journals (Sweden)

    Jan Lemeire

    2007-01-01

    Full Text Available Causal modeling and the accompanying learning algorithms provide useful extensions for in-depth statistical investigation and automation of performance modeling. We enlarged the scope of existing causal structure learning algorithms by using the form-free information-theoretic concept of mutual information and by introducing the complexity criterion for selecting direct relations among equivalent relations. The underlying probability distribution of experimental data is estimated by kernel density estimation. We then reported on the benefits of a dependency analysis and the decompositional capacities of causal models. Useful qualitative models, providing insight into the role of every performance factor, were inferred from experimental data. This paper reports on the results for a LU decomposition algorithm and on the study of the parameter sensitivity of the Kakadu implementation of the JPEG-2000 standard. Next, the analysis was used to search for generic performance characteristics of the applications.

  15. Towards Program Optimization through Automated Analysis of Numerical Precision.

    Science.gov (United States)

    Linderman, Michael D; Ho, Matthew; Dill, David L; Meng, Teresa H; Nolan, Garry P

    2010-04-01

    Reducing the arithmetic precision of a computation has real performance implications, including increased speed, decreased power consumption, and a smaller memory footprint. For some architectures, e.g., GPUs, there can be such a large performance difference that using reduced precision is effectively a requirement. The tradeoff is that the accuracy of the computation will be compromised. In this paper we describe a proof assistant and associated static analysis techniques for efficiently bounding numerical and precision-related errors. The programmer/compiler can use these bounds to numerically verify and optimize an application for different input and machine configurations. We present several case study applications that demonstrate the effectiveness of these techniques and the performance benefits that can be achieved with rigorous precision analysis.

  16. Interprocedural Analysis and the Verification of Concurrent Programs

    Science.gov (United States)

    2009-01-01

    first k execution contexts. Using that table, it figures out a valuation of Vark +1G to continue the analysis of T s 1 , and stores the effect that T s1...reached when T s1 is started in state (1, g1, · · · , gk+1) because T s1 could not have touched Vark +1G before the increment that changed k to k + 1. The

  17. Sensitivity Analysis of the Integrated Medical Model for ISS Programs

    Science.gov (United States)

    Goodenow, D. A.; Myers, J. G.; Arellano, J.; Boley, L.; Garcia, Y.; Saile, L.; Walton, M.; Kerstman, E.; Reyes, D.; Young, M.

    2016-01-01

    Sensitivity analysis estimates the relative contribution of the uncertainty in input values to the uncertainty of model outputs. Partial Rank Correlation Coefficient (PRCC) and Standardized Rank Regression Coefficient (SRRC) are methods of conducting sensitivity analysis on nonlinear simulation models like the Integrated Medical Model (IMM). The PRCC method estimates the sensitivity using partial correlation of the ranks of the generated input values to each generated output value. The partial part is so named because adjustments are made for the linear effects of all the other input values in the calculation of correlation between a particular input and each output. In SRRC, standardized regression-based coefficients measure the sensitivity of each input, adjusted for all the other inputs, on each output. Because the relative ranking of each of the inputs and outputs is used, as opposed to the values themselves, both methods accommodate the nonlinear relationship of the underlying model. As part of the IMM v4.0 validation study, simulations are available that predict 33 person-missions on ISS and 111 person-missions on STS. These simulated data predictions feed the sensitivity analysis procedures. The inputs to the sensitivity procedures include the number occurrences of each of the one hundred IMM medical conditions generated over the simulations and the associated IMM outputs: total quality time lost (QTL), number of evacuations (EVAC), and number of loss of crew lives (LOCL). The IMM team will report the results of using PRCC and SRRC on IMM v4.0 predictions of the ISS and STS missions created as part of the external validation study. Tornado plots will assist in the visualization of the condition-related input sensitivities to each of the main outcomes. The outcomes of this sensitivity analysis will drive review focus by identifying conditions where changes in uncertainty could drive changes in overall model output uncertainty. These efforts are an integral

  18. Enhanced Severe Transient Analysis for Prevention Technical Program Plan

    Energy Technology Data Exchange (ETDEWEB)

    Gougar, Hans [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2014-09-01

    This document outlines the development of a high fidelity, best estimate nuclear power plant severe transient simulation capability that will complement or enhance the integral system codes historically used for licensing and analysis of severe accidents. As with other tools in the Risk Informed Safety Margin Characterization (RISMC) Toolkit, the ultimate user of Enhanced Severe Transient Analysis and Prevention (ESTAP) capability is the plant decision-maker; the deliverable to that customer is a modern, simulation-based safety analysis capability, applicable to a much broader class of safety issues than is traditional Light Water Reactor (LWR) licensing analysis. Currently, the RISMC pathway’s major emphasis is placed on developing RELAP-7, a next-generation safety analysis code, and on showing how to use RELAP-7 to analyze margin from a modern point of view: that is, by characterizing margin in terms of the probabilistic spectra of the “loads” applied to systems, structures, and components (SSCs), and the “capacity” of those SSCs to resist those loads without failing. The first objective of the ESTAP task, and the focus of one task of this effort, is to augment RELAP-7 analyses with user-selected multi-dimensional, multi-phase models of specific plant components to simulate complex phenomena that may lead to, or exacerbate, severe transients and core damage. Such phenomena include: coolant crossflow between PWR assemblies during a severe reactivity transient, stratified single or two-phase coolant flow in primary coolant piping, inhomogeneous mixing of emergency coolant water or boric acid with hot primary coolant, and water hammer. These are well-documented phenomena associated with plant transients but that are generally not captured in system codes. They are, however, generally limited to specific components, structures, and operating conditions. The second ESTAP task is to similarly augment a severe (post-core damage) accident integral analyses code

  19. An analysis of the effects of prospective reimbursement programs on hospital expenditures.

    Science.gov (United States)

    Coelen, C; Sullivan, D

    1981-01-01

    Prospective reimbursement (PR) programs attempt to restrain increases in hospital expenditures by establishing, in advance of a hospital's fiscal year, limits on the reimbursement the hospital will receive for the services it provides to patients. We used data complied from a sample of approximately 2700 community hospitals in the U.S. for each year from 1969 to 1978 to estimate the effects of prospective reimbursement programs on hospital expenditures per patient day, per admission, and, to a lesser extent, per capita. The statistical evidence indicates that some PR programs have been successful in reducing hospital expenditures per patient day, per admission, and per capita. Eight programs--in Arizona, Connecticut, Maryland, Massachusetts, Minnesota, New Jersey, New York, and Rhode Island--have reduced the rate of increase in expenses by 2 percentage points or more per year and, in some cases, by as much as 4 to 6 percentage points. There are indications, although less strong, that PR programs also reduced expenses in Indiana, Kentucky, Washington, western Pennsylvania, and Wisconsin. There are no indications of cost reductions for programs in Colorado and Nebraska. An analysis of the relative effectiveness of the various programs suggests that mandatory programs have a significantly higher probability of influencing hospital behavior than do voluntary programs. Some voluntary programs, however, are shown to be effective.

  20. Integrated Data Collection Analysis (IDCA) Program — Quarterly Review Meeting

    Energy Technology Data Exchange (ETDEWEB)

    Sandstrom, Mary M. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Brown, Geoffrey W. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Warner, Kirstin F. [Naval Surface Warfare Center (IHD-NSWC), Indian Head, MD (United States). Indian Head Division; Sorensen, Daniel N. [Naval Surface Warfare Center (IHD-NSWC), Indian Head, MD (United States). Indian Head Division; Remmers, Daniel L. [Naval Surface Warfare Center (IHD-NSWC), Indian Head, MD (United States). Indian Head Division; Shelley, Timothy J. [Air Force Research Lab. (AFRL/RXQF), Tyndall AFB, FL (United States); Reyes, Jose A. [Applied Research Associates, Inc., Tyndall AFB, FL (United States); Phillips, Jason J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Hsu, Peter C. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Reynolds, John G. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2011-12-05

    On November 9 and 10, 2011 the IDCA had the annual quarterly meeting. The meeting started the afternoon of the first day with a tour of the NSWC IHD explosives safety testing and analysis facilities. The meeting on the second day addressed the formal sponsor review and further technical issues for the IDCA. Examination of the IHD equipment during the tour, lead to a long discussion on liquid test methods. The discussion resulted in revision of liquid test methods in the impact test and selection of a new liquid test standard. In addition, modifications to friction, spark and thermal test methods were discussed.

  1. Optimization Models for Islanded Micro-Grids: A Comparative Analysis between Linear Programming and Mixed Integer Programming

    Directory of Open Access Journals (Sweden)

    Alberto Dolara

    2017-02-01

    Full Text Available This paper presents a comparison of optimization methods applied to islanded micro-grids including renewable energy sources, diesel generators and battery energy storage systems. In particular, a comparative analysis between an optimization model based on linear programming and a model based on mixed integer programming has been carried out. The general formulation of these models has been presented and applied to a real case study micro-grid installed in Somalia. The case study is an islanded micro-grid supplying the city of Garowe by means of a hybrid power plant, consisting of diesel generators, photovoltaic systems and batteries. In both models the optimization is based on load demand and renewable energy production forecast. The optimized control of the battery state of charge, of the spinning reserve and diesel generators allows harvesting as much renewable power as possible or to minimize the use of fossil fuels in energy production.

  2. The Impact of Programming Experience on Successfully Learning Systems Analysis and Design

    Science.gov (United States)

    Wong, Wang-chan

    2015-01-01

    In this paper, the author reports the results of an empirical study on the relationship between a student's programming experience and their success in a traditional Systems Analysis and Design (SA&D) class where technical skills such as dataflow analysis and entity relationship data modeling are covered. While it is possible to teach these…

  3. A Critical Multicultural Analysis of a Romanian Textbook Taught in Elementary International Language Programs

    Science.gov (United States)

    Stoilescu, Dorian

    2014-01-01

    This case study proposes a critical multicultural analysis of a Romanian language textbook used for instructing students in grades one and two in the Elementary Language International Program (ELIP) in Toronto public schools in Ontario, Canada. Based on an analysis developed from Fairclough and Parker's criteria, this paper determined stereotypes…

  4. Racial Harmony & Heroes: A Content Analysis of the Pearson Reading Program "Good Habits, Great Readers"

    Science.gov (United States)

    Tosolt, Brandelyn; Love, Bettina L.

    2011-01-01

    Multicultural education is a term with a variety of definitions growing from a number of different disciplines. These authors conducted a content analysis of the Pearson reading program "Good Habits, Great Readers" for grades four and five. The qualitative approach of content analysis allowed researchers to examine text "through the…

  5. Cost-Effectiveness Analysis of Early Reading Programs: A Demonstration with Recommendations for Future Research

    Science.gov (United States)

    Hollands, Fiona M.; Kieffer, Michael J.; Shand, Robert; Pan, Yilin; Cheng, Henan; Levin, Henry M.

    2016-01-01

    We review the value of cost-effectiveness analysis for evaluation and decision making with respect to educational programs and discuss its application to early reading interventions. We describe the conditions for a rigorous cost-effectiveness analysis and illustrate the challenges of applying the method in practice, providing examples of programs…

  6. Inference of Well-Typings for Logic Programs with Application to Termination Analysis

    DEFF Research Database (Denmark)

    Bruynooghe, M.; Gallagher, John Patrick; Humbeeck, W. Van

    2005-01-01

    A method is developed to infer a polymorphic well-typing for a logic program. Our motivation is to improve the automation of termination analysis by deriving types from which norms can automatically be constructed. Previous work on type-based termination analysis used either types declared...

  7. Linear circuit analysis program for IBM 1620 Monitor 2, 1311/1443 data processing system /CIRCS/

    Science.gov (United States)

    Hatfield, J.

    1967-01-01

    CIRCS is modification of IBSNAP Circuit Analysis Program, for use on smaller systems. This data processing system retains the basic dc, transient analysis, and FORTRAN 2 formats. It can be used on the IBM 1620/1311 Monitor I Mod 5 system, and solves a linear network containing 15 nodes and 45 branches.

  8. Statistics and quality assurance for the Northern Research Station Forest Inventory and Analysis Program, 2016

    Science.gov (United States)

    Dale D. Gormanson; Scott A. Pugh; Charles J. Barnett; Patrick D. Miles; Randall S. Morin; Paul A. Sowers; Jim Westfall

    2017-01-01

    The U.S. Forest Service Forest Inventory and Analysis (FIA) program collects sample plot data on all forest ownerships across the United States. FIA's primary objective is to determine the extent, condition, volume, growth, and use of trees on the Nation's forest land through a comprehensive inventory and analysis of the Nation's forest resources. The...

  9. Analysis of Recruit Attrition from the Navy’s Delayed Entry Program and Recruit Training Command

    Science.gov (United States)

    2007-12-01

    Matrix is depicted below in Figure 1. 3 Jennie W. Wenger and April K. Hodari, Final Analysis of Evaluation of Homeschool and...J. W. and Hodari, A. K., Final Analysis of Evaluation of Homeschool and ChalleNGe Program Recruits. Alexandria, VA: CNA Corporation, 2004. Wirt, J

  10. Policy analysis of the dengue control program in Mexico.

    Science.gov (United States)

    González Fernández, Mariana I; Orozco Núñez, Emanuel; Cifuentes, Enrique

    2010-12-01

    To analyze municipal measures implemented to control the dengue epidemic, giving priority to the functions of intersectoral coordination, policy strengthening and community participation. The observational study was performed in Morelos, Mexico in 2007. Data collected in interviews and direct observations were submitted to contents analysis and policy mapping. Policy Maker software was used to evaluate the values assigned to the stakeholders' performance (i.e., high, medium and low criteria) and to their role (actions undertaken for surveillance, control or management). A strategic analysis of opportunities and challenges regarding public policies and dengue control was conducted. The legal framework indicates that the approach to the dengue epidemic should be an intersectoral response. However, the burden of activities in terms of financial and human resources tends to fall on local health services, which contrasts with the contribution of other sectors (e.g., water and sanitation) that do not recognize their responsibilities. A high degree of operational feasibility links, in terms of optimization of resources and objectives fulfillment was detected, particularly among health authorities at state, jurisdictional and municipal levels. A multidisciplinary approach and strengthening of policy stewardship may allow a more efficient response to dengue outbreaks, sustained by intersectoral coordination and the active participation of the affected population.

  11. Data Science Programs in U.S. Higher Education: An Exploratory Content Analysis of Program Description, Curriculum Structure, and Course Focus

    Science.gov (United States)

    Tang, Rong; Sae-Lim, Watinee

    2016-01-01

    In this study, an exploratory content analysis of 30 randomly selected Data Science (DS) programs from eight disciplines revealed significant gaps in current DS education in the United States. The analysis centers on linguistic patterns of program descriptions, curriculum requirements, and DS course focus as pertaining to key skills and domain…

  12. A meta-analysis of the effect of school-based anti-bullying programs.

    Science.gov (United States)

    Lee, Sunhee; Kim, Chun-Ja; Kim, Dong Hee

    2015-06-01

    Bullying is a serious public health problem, and many studies have examined the effect of school-based anti-bullying programs. However, these programs and those outcomes are complex, broad, and diverse. Research is needed into the optimal strategies for these comprehensive programs, which consider both the effectiveness and cost of programs. We performed a meta-analysis of 13 studies using the Comprehensive Meta-Analysis software package to calculate effect size (ES) and the Q statistic. We conducted subgroup analyses to examine the differences based on student grade level, program duration, and program strategy. The pooled ES calculation indicated that school-based anti-bullying programs have a small to moderate effect on victimization. The results of the Q test indicated significant heterogeneity across studies of victimization (Q = 39.625; I (2) = 69.7%; p bullying (p bullying programs should include training in emotional control, peer counseling, and the establishment of a school policy on bullying. © The Author(s) 2013.

  13. Analysis to develop a program for energy-integrated farm systems

    Energy Technology Data Exchange (ETDEWEB)

    Eakin, D.E.; Clark, M.A.; Inaba, L.K.; Johnson, K.I.

    1981-09-01

    A program to use renewable energy resources and possibly develop decentralization of energy systems for agriculture is discussed. The purpose of the research presented is to establish the objective of the program and identify guidelines for program development. The program's objective is determined by: (1) an analysis of the technologies that could be utilized to transform renewable farm resources to energy by the year 2000, (2) the quantity of renewable farm resources that are available, and (3) current energy-use patterns. Individual research, development, and demonstration projects are fit into a national program of energy-integrated farm systems on the basis of: (1) market need, (2) conversion potential, (3) technological opportunities, and (4) acceptability. Quantification of these factors for the purpose of establishing program guidelines is conducted using the following four precepts: (1) market need is identified by current use of energy for agricultural production; (2) conversion potential is determined by the availability of renewable resources; and (3) technological opportunities are determined by the state-of-the-art methods, techniques, and processes that can convert renewable resources into farm energy. Each of these factors is analyzed in Chapters 2 to 4. Chapter 5 draws on the analysis of these factors to establish the objective of the program and identify guidelines for the distribution of program funds. Chapter 6 then discusses the acceptability of integrated farm systems, which can not be quantified like the other factors.

  14. Macro-economic benefit analysis of large scale building energy efficiency programs in Qatar

    Directory of Open Access Journals (Sweden)

    Moncef Krarti

    2017-12-01

    Full Text Available This paper evaluates the economic, environmental, and social benefits of large-scale energy efficiency programs for new and existing buildings in Qatar. Using data obtained from detailed energy audits, several proven energy efficiency measures have been analyzed through optimized based analysis to assess their impact on the energy performance for both new and existing buildings in Qatar. Moreover, a bottom-up analysis approach is considered to quantify the multiple benefits for implementing large-scale building energy efficiency programs for the building stock in Qatar. In particular, a more stringent energy efficiency code for the new constructions and three energy retrofit levels for the existing buildings are considered in the analysis. A novel macro-economic analysis using the concept of energy productivity is used to assess the cost-benefit of large-scale energy efficiency programs in Qatar. It is determined that the implementation of a government funded large-scale energy retrofit program for the existing building stock is highly cost-effective in Qatar. In particular, it is found that a large-scale energy efficiency retrofit program of existing buildings can provide a reduction of 11,000 GWh in annual electricity consumption and 2500 MW in peak demand as well as over 5400 kilo-ton per year in carbon emissions. In addition, over 4000 jobs per year can be created when this large-scale energy retrofit program is implemented over 10-year period.

  15. Development of the static analyzer ANALYSIS/EX for FORTRAN programs

    Energy Technology Data Exchange (ETDEWEB)

    Osanai, Seiji; Yokokawa, Mitsuo [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    1993-08-01

    The static analyzer `ANALYSIS` is the software tool for analyzing tree structure and COMMON regions of a FORTRAN program statically. With the installation of the new FORTRAN compiler, FORTRAN77EX(V12), to the computer system at JAERI, a new version of ANALYSIS, `ANALYSIS/EX`, has been developed to enhance its analyzing functions. In addition to the conventional functions of ANALYSIS, the ANALYSIS/EX is capable of analyzing of FORTRAN programs written in the FORTRAN77EX(V12) language grammar such as large-scale nuclear codes. The analyzing function of COMMON regions are also improved so as to obtain the relation between variables in COMMON regions in more detail. In this report, results of improvement and enhanced functions of the static analyzer ANALYSIS/EX are presented. (author).

  16. [An analysis of cancer survival narratives using computerized text analysis program].

    Science.gov (United States)

    Kim, Dal Sook; Park, Ah Hyun; Kang, Nam Jun

    2014-06-01

    This study was done to explore experiences of persons living through the periods of cancer diagnosis, treatment, and self-care. With permission, texts of 29 cancer survival narratives (8 men and 21 women, winners in contests sponsored by two institutes), were analyzed using Kang's Korean-Computerized-Text-Analysis-Program where the commonly used Korean-Morphological-Analyzer and the 21st-century-Sejong-Modern-Korean-Corpora representing laymen's Korean-language-use are connected. Experiences were explored based on words included in 100 highly-used-morphemes. For interpretation, we used 'categorizing words by meaning', 'comparing use-rate by periods and to the 21st-century-Sejong-Modern-Korean-Corpora', and highly-used-morphemes that appeared only in a specific period. The most highly-used-word-morpheme was first-person-pronouns followed by, diagnosis·treatment-related-words, mind-expression-words, cancer, persons-in-meaningful-interaction, living and eating, information-related-verbs, emotion-expression-words, with 240 to 0.8 times for layman use-rate. 'Diagnosis-process', 'cancer-thought', 'things-to-come-after-diagnosis', 'physician·husband', 'result-related-information', 'meaningful-things before diagnosis-period', and 'locus-of-cause' dominated the life of the diagnosis-period. 'Treatment', 'unreliable-body', 'husband · people · mother · physician', 'treatment-related-uncertainty', 'hard-time', and 'waiting-time represented experiences in the treatment-period. Themes of living in the self-care-period were complex and included 'living-as-a-human', 'self-managing-of-diseased-body', 'positive-emotion', and 'connecting past · present · future'. The results show that the experience of living for persons with cancer is influenced by each period's own situational-characteristics. Experiences of the diagnosis and treatment-period are negative disease-oriented while that of the self-care period is positive present-oriented.

  17. A Meta-Analysis of Empirically Tested School-Based Dating Violence Prevention Programs

    Directory of Open Access Journals (Sweden)

    Sarah R. Edwards

    2014-05-01

    Full Text Available Teen dating violence prevention programs implemented in schools and empirically tested were subjected to meta-analysis. Eight studies met criteria for inclusion, consisting of both within and between designs. Overall, the weighted mean effect size (ES across studies was significant, ESr = .11; 95% confidence interval (CI = [.08, .15], p < .0001, showing an overall positive effect of the studied prevention programs. However, 25% of the studies showed an effect in the negative direction, meaning students appeared to be more supportive of dating violence after participating in a dating violence prevention program. This heightens the need for thorough program evaluation as well as the need for decision makers to have access to data about the effectiveness of programs they are considering implementing. Further implications of the results and recommendations for future research are discussed.

  18. Structural analysis of underground gunite storage tanks. Environmental Restoration Program

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-08-01

    This report documents the structural analysis of the 50-ft diameter underground gunite storage tanks constructed in 1943 and located in the Oak Ridge National Laboratory (ORNL) South Tank Farm, known as Facility 3507 in the 3500-3999 area. The six gunite tanks (W-5 through W-10) are spaced in a 2 {times} 3 matrix at 60 ft on centers with 6 ft of soil cover. Each tank (Figures 1, 2, and 3) has an inside diameter of 50 ft, a 12-ft vertical sidewall having a thickness of 6 in. (there is an additional 1.5-in. inner liner for much of the height), and a spherical domed roof (nominal thickness is 10 in.) rising another 6 ft, 3 in. at the center of the tank. The thickness of both the sidewall and the domed roof increases to 30 in. near their juncture. The tank floor is nominally 3-in. thick, except at the juncture with the wall where the thickness increases to 9 in. The tanks are constructed of gunite (a mixture of Portland cement, sand, and water in the form of a mortar) sprayed from the nozzle of a cement gun against a form or a solid surface. The floor and the dome are reinforced with one layer of welded wire mesh and reinforcing rods placed in the radial direction. The sidewall is reinforced with three layers of welded wire mesh, vertical {1/2}-in. rods, and 21 horizontal rebar hoops (attached to the vertical rods) post-tensioned to 35,000 psi stress. The haunch at the sidewall/roof junction is reinforced with 17 horizontal rebar hoops post-tensioned with 35,000 to 40,000 psi stress. The yield strength of the post-tensioning steel rods is specified to be 60,000 psi, and all other steel is 40,000 psi steel. The specified 28-day design strength of the gunite is 5,000 psi.

  19. Innovative Molecular Analysis Technologies Program Funding Opportunities | Office of Cancer Clinical Proteomics Research

    Science.gov (United States)

    The NCI is very pleased to announce that the Innovative Molecular Analysis Technologies (IMAT) program funding opportunity announcements have been posted for calendar year (CY) 2013. Please visit this website for more information on these announcements. For your convenience, a link to each solicitation is provided below with associated submission deadlines for new applications and resubmissions. Please contact the NCI IMAT program director, Dr.

  20. Forest inventory and analysis program in the Western U.S.

    Science.gov (United States)

    Ashley. Lehman

    2015-01-01

    The Pacific Northwest (PNW) Research Station’s Forest Inventory and Analysis (FIA) program of the USDA Forest Service monitors and reports on the status and trends of the Pacific Island’s forest resources and ecosystem services. Since 2001 the FIA program has partnered with State and Private Forestry’s, Region 5 and the local governments in the U.S. Affiliated Western...

  1. Noise studies of communication systems using the SYSTID computer aided analysis program

    Science.gov (United States)

    Tranter, W. H.; Dawson, C. T.

    1973-01-01

    SYSTID computer aided design is a simple program for simulating data systems and communication links. A trial of the efficiency of the method was carried out by simulating a linear analog communication system to determine its noise performance and by comparing the SYSTID result with the result arrived at by theoretical calculation. It is shown that the SYSTID program is readily applicable to the analysis of these types of systems.

  2. Scenario Analysis of Web Service Composition based on Multi-Criteria Mathematical Goal Programming

    OpenAIRE

    LiYing Cui; Soundar Kumara; Dongwon Lee

    2011-01-01

    This paper addresses the web service composition problem considering multi-criteria regarding quality of services (QoS). Three different scenarios of multi-criteria mathematical programming models are explored under the framework of network based analysis in web service composition. This work takes care of the issues pertaining to inputs and outputs matching of web services and Quality-of-Service (QoS) at the same time. The multi-criteria programming models are explored to select the desirabl...

  3. SYNCH: A program for design and analysis of synchrotrons and beamlines -- user`s guide

    Energy Technology Data Exchange (ETDEWEB)

    Garren, A.A.; Kenney, A.S.; Courant, E.D.; Russell, A.D.; Syphers, M.J.

    1993-12-31

    SYNCH is a computer program for use in the design and analysis of synchrotrons, storage rings, and beamlines. It has a large repertoire of commands that can be accessed in a flexible way. The input statements and the results of the calculations they invoke are saved in an internal database so that this information may be shared by other statements. SYNCH is the first accelerator program to organize its input in the form of a language. The statements, which resemble sentences, provide a natural way of describing lattices and invoking relevant calculations. The organization of the program is modular, so that it has been possible to expand its capabilities progressively.

  4. Wind Atlas Analysis and Application Program: WAsP 11 Help Facility

    DEFF Research Database (Denmark)

    2014-01-01

    The Wind Atlas Analysis and Application Program (WAsP) is a PC-program for horizontal and vertical extrapolation of wind climates. The program contains a complete set of models to calculate the effects on the wind of sheltering obstacles, surface roughness changes and terrain height variations...... of specific wind turbines and wind farms. The WAsP Help Facility includes a Quick Start Tutorial, a User's Guide and a Technical Reference. It further includes descriptions of the Observed Wind Climate Wizard, the WAsP Climate Analyst, the WAsP Map Editor tool, the WAsP Turbine Editor tool, the Air Density...

  5. TIME ANALYSIS ACCORDING TO PART PROGRAMS ON A CNC VERTICAL MACHINING CENTER

    Directory of Open Access Journals (Sweden)

    Ahmet Murat PİNAR

    2002-01-01

    Full Text Available In this study, a program examining the CNC programs in the control unit of Dyna Myte 2900 Vertical Machining Center and calculating the machining time and rapid movement time of the cutting tools has been developed. The workpiece program to be examined is transferred to CNC code editor by the user manually, by a computer file with a diskette, or through hard disk or the machine tool. By examining all the movements of the cutting tools, detailed machining time, rapid movement time or total time is served to the user. So that, an important part of workpiece cost analysis information is provided.

  6. A meta-analysis of the effects of dropout prevention programs on school absenteeism.

    Science.gov (United States)

    Tanner-Smith, Emily E; Wilson, Sandra Jo

    2013-10-01

    This study reports findings from a systematic review and meta-analysis of literature examining the effects of school dropout prevention and intervention programs on students' school absenteeism outcomes. The meta-analysis synthesized 74 effect sizes measuring posttest differences in school absenteeism outcomes for youth enrolled in dropout prevention programs relative to a comparison group. Although results from randomized controlled trials indicated significant beneficial program effects, findings from quasi-experimental studies indicated no significant beneficial or detrimental effects. Examination of study characteristics suggested that dropout programs may have beneficial effects on school absenteeism among primarily male samples, and younger samples. Although no single type of intervention program was consistently more effective than others, vocational oriented and supplemental academic training programs showed some promise. However, the inconsistency in results and the possibility of small study bias mean the quality of evidence in this literature is low; at this time there is not enough evidence to conclude that dropout prevention programs have a universal impact on youth's school absenteeism outcomes.

  7. How can schools help youth increase physical activity? An economic analysis comparing school-based programs.

    Science.gov (United States)

    Babey, Susan H; Wu, Shinyi; Cohen, Deborah

    2014-12-01

    For optimal health, physical activity should be an integral and routine part of daily life. Youth spend a significant amount of time at school yet rarely achieve the recommended 60 min of moderate and vigorous physical activity in physical education (PE) classes or recess. This study assessed the following types of school-based opportunities to improve physical activity for youth: after-school programs, before-school programs, PE classes, extended-day PE, and short physical activity breaks during the school day. An economic analysis conducted in 2013 compared school-based approaches to increasing physical activity. Analysis factors included costs, reach, effects on physical activity gains, cost-effectiveness, and other potentially augmenting benefits. Two programs were significantly superior in terms of reach and cost per student: (1) extending the school day with mandatory PE participation and (2) offering short (10-minute) physical activity breaks during regular classroom hours. After-school program costs per student are high and the programs have a smaller reach, but they offer benefits (such as childcare) that may justify their higher costs. Before-school programs did not appear feasible. Incorporating short physical activity breaks into the existing school day would be a cost-effective way to increase school-based activity. This type of program is inexpensive and has broad reach. Inserting activity breaks throughout the day is appropriate, especially when youth are otherwise largely sedentary. Copyright © 2014 Elsevier Inc. All rights reserved.

  8. PKSolver: An add-in program for pharmacokinetic and pharmacodynamic data analysis in Microsoft Excel.

    Science.gov (United States)

    Zhang, Yong; Huo, Meirong; Zhou, Jianping; Xie, Shaofei

    2010-09-01

    This study presents PKSolver, a freely available menu-driven add-in program for Microsoft Excel written in Visual Basic for Applications (VBA), for solving basic problems in pharmacokinetic (PK) and pharmacodynamic (PD) data analysis. The program provides a range of modules for PK and PD analysis including noncompartmental analysis (NCA), compartmental analysis (CA), and pharmacodynamic modeling. Two special built-in modules, multiple absorption sites (MAS) and enterohepatic circulation (EHC), were developed for fitting the double-peak concentration-time profile based on the classical one-compartment model. In addition, twenty frequently used pharmacokinetic functions were encoded as a macro and can be directly accessed in an Excel spreadsheet. To evaluate the program, a detailed comparison of modeling PK data using PKSolver and professional PK/PD software package WinNonlin and Scientist was performed. The results showed that the parameters estimated with PKSolver were satisfactory. In conclusion, the PKSolver simplified the PK and PD data analysis process and its output could be generated in Microsoft Word in the form of an integrated report. The program provides pharmacokinetic researchers with a fast and easy-to-use tool for routine and basic PK and PD data analysis with a more user-friendly interface. Copyright 2010 Elsevier Ireland Ltd. All rights reserved.

  9. Adding Change Impact Analysis to the Formal Verification of C Programs

    Science.gov (United States)

    Autexier, Serge; Lüth, Christoph

    Handling changes to programs and specifications efficiently is a particular challenge in formal software verification. Change impact analysis is an approach to this challenge where the effects of changes made to a document (such as a program or specification) are described in terms of rules on a semantic representation of the document. This allows to describe and delimit the effects of syntactic changes semantically. This paper presents an application of generic change impact analysis to formal software verification, using the GMoC and SAMS tools. We adapt the GMoC tool for generic change impact analysis to the SAMS verification framework for the formal verification of C programs, and show how a few simple rules are sufficient to capture the essence of change management.

  10. National program for family planning and primary health care Pakistan: a SWOT analysis.

    Science.gov (United States)

    Wazir, Mohammad Salim; Shaikh, Babar Tasneem; Ahmed, Ashfaq

    2013-11-22

    The National Program for Family Planning and Primary Healthcare was launched in 1994. It is one of the largest community based programs in the world, providing primary healthcare services to about 80 million people, most of which is rural poor. The program has been instrumental in improving health related indicators of maternal and child health in the last two decades. SWOT analysis was used by making recourse to the structure and dynamics of the program as well as searching the literature. Strengths of the program include: comprehensive design of planning, implementation and supervision mechanisms aided by an MIS, selection and recruitments processes and evidence created through improving health impact indicators. Weaknesses identified are slow progress, poor integration of the program with health services at local levels including MIS, and de-motivational factors such as job insecurity and non-payment of salaries in time. Opportunities include further widening the coverage of services, its potential contribution to health system research, and its use in areas other than health like women empowerment and poverty alleviation. Threats the program may face are: political interference, lack of funds, social threats and implications for professional malpractices. Strengthening of the program will necessitate a strong political commitment, sustained funding and a just remuneration to this bare foot doctor of Pakistan, the Lady Health Worker.

  11. A Meta-analysis of universal mental health prevention programs for higher education students.

    Science.gov (United States)

    Conley, Colleen S; Durlak, Joseph A; Kirsch, Alexandra C

    2015-05-01

    This meta-analysis investigated the effectiveness of universal mental health prevention programs for higher education students on a range of adjustment outcomes. A systematic literature search identified 103 controlled published and unpublished interventions involving college, graduate, or professional students. As hypothesized, skill-training programs that included a supervised practice component were significantly more effective overall (mean effect size = 0.45, confidence interval (CI) = 0.39 to 0.52) compared to skill-training programs without supervised practice (0.11, CI = -0.01 to 0.22) and psychoeducational (information-only) programs (0.13, CI = 0.06 to 0.21). When comparisons on specific outcomes were possible, skill-training programs including supervised practice were significantly more effective than the other two groups of programs in reducing symptoms of depression, anxiety, stress, and general psychological distress, and in improving social-emotional skills, self-perceptions, and academic behaviors and performance. The magnitude of effects achieved in several outcome areas is comparable to or higher than that reported in other reviews of universal programs, suggesting that skill-training programs for higher education students that incorporate supervised practice now join the ranks of other effective preventive mental health interventions. This review offers several recommendations to improve the experimental rigor of future research.

  12. FY 2016 Grant Announcement: FY 2016 Technical Analysis and Programmatic Evaluation Support to the Chesapeake Bay Program Partnership

    Science.gov (United States)

    The U.S. Environmental Protection Agency’s Chesapeake Bay Program Office is announcing a Request for Proposals for applicants to provide the Chesapeake Bay Program partners with a proposal(s) for providing technical analysis and programmatic evaluation

  13. A Ballistic Limit Analysis Program for Shielding Against Micrometeoroids and Orbital Debris

    Science.gov (United States)

    Ryan, Shannon; Christiansen, Erie

    2010-01-01

    A software program has been developed that enables the user to quickly and simply perform ballistic limit calculations for common spacecraft structures that are subject to hypervelocity impact of micrometeoroid and orbital debris (MMOD) projectiles. This analysis program consists of two core modules: design, and; performance. The design module enables a user to calculate preliminary dimensions of a shield configuration (e.g., thicknesses/areal densities, spacing, etc.) for a ?design? particle (diameter, density, impact velocity, incidence). The performance module enables a more detailed shielding analysis, providing the performance of a user-defined shielding configuration over the range of relevant in-orbit impact conditions.

  14. Integrated use of computer programs for analysis and optimization of aircraft structures

    Science.gov (United States)

    Moon, Young IN

    1990-01-01

    The objective is to present results from investigating the integrated use of five computer programs: ANALYZE, ASTROS, NASTRAN, OPTSTAT, and VAASEL for analysis and optimization of a given structure. The structure designated for study purposes was the F-15E vertical tail. The concept of integrated use is limited to the capability of using a NASTRAN structural model to run each of the other specified programs. This was actually accomplished in practice by converting a NASTRAN model of the designated structure into an appropriate analysis model. For optimization purposes, the torque-box of the F-15E vertical tail was used.

  15. STATA Programs for Using the Intermediate Data Structure (IDS to Construct Files for Statistical Analysis

    Directory of Open Access Journals (Sweden)

    Luciana Quaranta

    2016-02-01

    Full Text Available The Intermediate Data Structure (IDS provides a common structure for storing and sharing historical demographic data. The structure also facilitates the construction of different open-access software to extract information from these tables and construct new variables. The article Using the Intermediate Data Structure (IDS to Construct Files for Analysis (Quaranta 2015 presented a series of concepts and programs that allow the user to construct a rectangular episodes file for longitudinal statistical analysis using data stored in the IDS. The current article discusses, in detail, each of these programs, describing their technicalities, structure and syntax, and also explaining how they can be used.

  16. [Curriculum analysis and comparison between strategies or programs for early child development in Mexico].

    Science.gov (United States)

    Vargas-López, Guillermo; Guadarrama-Orozco, Jessica Haydee; Rizzoli-Córdoba, Antonio; Narcizo-Cenobio, Francisco Javier; Medrano-Loera, Gerónimo; Villagrán, Daniel Aceves; O'Shea Cuevas, Gabriel; Muñoz Hernández, Onofre

    Most of the strategies or programs that support early child development in Mexico are independent efforts that vary in scale, services offered and means of providing them. For the evaluation of the quality of these programs, an important aspect is the curriculum content. The aim of this study was to analyze and compare the curriculum content of the different strategies or programs focused on the promotion and intervention of early child development, which are offered by the Federal Government in Health and Education sectors in Mexico. We conducted a review of the curriculum content of the strategies and programs. The qualitative phase consisted of a comparative analysis where 75 indicators proposed by the Inter-American Development Bank were identified. The quantitative phase consisted of a descriptive analysis of the indicators. Finally, the analyses were compared to establish the performance of each one. Six strategies or programs were identified. In the analysis of the presence of indicators, the Oportunidades de Aprendizaje (Learning Opportunities, LO) strategy showed a larger number of indicators. In the amplitude analysis, both PEI-CONAFE and LO were the best balanced. Finally, in-depth analysis of the indicators LO and Skills for life were the best balanced while PEI-CONAFE was the best balanced in the social-emotional area, CeNSIA program for language and LO for cognitive development area. LO strategy showed the closest level of contents established by the Inter-American Development Bank. Copyright © 2016 Hospital Infantil de México Federico Gómez. Publicado por Masson Doyma México S.A. All rights reserved.

  17. Parent Training Programs for Ethnic Minorities: a Meta-analysis of Adaptations and Effect.

    Science.gov (United States)

    van Mourik, K; Crone, M R; de Wolff, M S; Reis, R

    2017-01-01

    This meta-analysis focuses on parent training programs for ethnic minority families and reports on (i) the adaptation of program content and (ii) the process that informs these adaptations. Relevant studies are reviewed to determine the adaptations made and the impact of the adaptations on parenting and child outcomes. Studies were eligible for inclusion if they enrolled predominantly ethnic minority parents with children aged 0-12 years, used a randomized controlled trial design with post-intervention assessments, focused on group-based parent training programs and on prevention of parenting problems, and reported parenting behavior outcomes. A total of 18 studies were included in the analysis. The results show that parent training programs targeting ethnic minority parents have a small but significant effect on improving parenting behavior (k = 18, Cohen's d = 0.30), child outcomes (k = 16, Cohen's d = 0.13), and parental perspectives (k = 8, Cohen's d = 0.19). Most of the programs made adaptations related to surface and deep structure sensitivity. Programs with cultural adaptations, especially deep structure sensitivity (k = 7, Cohen's d = 0.54), are more effective in improving parenting behavior. Because only a third of the included studies provided details on the processes that guided the adaptations made, additional studies are needed to provide information on the process of adaptation; this will enable others to learn from the procedures that can be undertaken to culturally adapt interventions.

  18. Prevention of child sexual abuse victimization: a meta-analysis of school programs.

    Science.gov (United States)

    Rispens, J; Aleman, A; Goudena, P P

    1997-10-01

    The aim of this article was to provide data about the effects of child sexual abuse prevention programs. A more specific aim was to estimate the contribution of potential moderator variables such as age, program duration, or sample size to effect size. A meta-analytic approach was used to calculate post-test and follow-up effect sizes of 16 evaluation studies of school programs aimed at the prevention of child sexual abuse victimization. Tests of categorical models were used in the analysis of moderator variables. Multiple regression analysis was used to determine their association with effect sizes. Significant and considerable mean post-intervention (d = .71) and follow-up (d = .62) effect sizes were found, indicating that victimization prevention programs are successful in teaching children sexual abuse concepts and self-protection skills. Intervention characteristics such as duration and content of the program, and child characteristics such as age and SES were important moderators of effect size. Our findings corroborate and refine the positive conclusions of traditional narrative reviews. Programs that focus on skill training, allowing sufficient time for children to integrate self-protection skills into their cognitive repertoire, are to be preferred. Future evaluation research should focus on transfer of training.

  19. Analysis of medical students' needs for development of a career guidance program.

    Science.gov (United States)

    An, Hyejin; Kim, Eunjeong; Hwang, Jinyoung; Lee, Seunghee

    2014-09-01

    The purpose of this study is to provide basic data for the development of a career guidance program through a demand survey. For this purpose, three study topics were examined: Is there a difference between the satisfaction and importance of a career program? Is there a difference between the satisfaction and importance of a career program by gender, grade level? and What type of mentor and the mentoring way of medical students demanded? The subjects were 380 students at Seoul National University College of Medicine. The data were analyzed by frequency analysis, paired t-test, and Borich's formula. By t-test with matched samples for satisfaction-importance, We noted statistically significant differences in all domains. In particular, the difference was greater in the second year. According to the needs analysis, the most urgent program is meeting with seniors in various career areas. Also, medical students hope for mentor from clinical professors of the university and successful medical practitioners, and personal counseling. These results show that medical students need a career guidance program. The findings of the study can be used to guide the development of career education programs and curriculum for medicine students.

  20. Methodological Framework for Analysis of Buildings-Related Programs: The GPRA Metrics Effort

    Energy Technology Data Exchange (ETDEWEB)

    Elliott, Douglas B.; Anderson, Dave M.; Belzer, David B.; Cort, Katherine A.; Dirks, James A.; Hostick, Donna J.

    2004-06-18

    The requirements of the Government Performance and Results Act (GPRA) of 1993 mandate the reporting of outcomes expected to result from programs of the Federal government. The U.S. Department of Energy’s (DOE’s) Office of Energy Efficiency and Renewable Energy (EERE) develops official metrics for its 11 major programs using its Office of Planning, Budget Formulation, and Analysis (OPBFA). OPBFA conducts an annual integrated modeling analysis to produce estimates of the energy, environmental, and financial benefits expected from EERE’s budget request. Two of EERE’s major programs include the Building Technologies Program (BT) and Office of Weatherization and Intergovernmental Program (WIP). Pacific Northwest National Laboratory (PNNL) supports the OPBFA effort by developing the program characterizations and other market information affecting these programs that is necessary to provide input to the EERE integrated modeling analysis. Throughout the report we refer to these programs as “buildings-related” programs, because the approach is not limited in application to BT or WIP. To adequately support OPBFA in the development of official GPRA metrics, PNNL communicates with the various activities and projects in BT and WIP to determine how best to characterize their activities planned for the upcoming budget request. PNNL then analyzes these projects to determine what the results of the characterizations would imply for energy markets, technology markets, and consumer behavior. This is accomplished by developing nonintegrated estimates of energy, environmental, and financial benefits (i.e., outcomes) of the technologies and practices expected to result from the budget request. These characterizations and nonintegrated modeling results are provided to OPBFA as inputs to the official benefits estimates developed for the Federal Budget. This report documents the approach and methodology used to estimate future energy, environmental, and financial benefits

  1. [Analysis on the availability of programs and services for elderly people in Puerto Rico].

    Science.gov (United States)

    López León, R

    2001-03-01

    This research was conducted with the purpose of analyzing the programs and services available to the aged population in the municipalities of Puerto Rico during 1999 and 2000. The analysis was performed using an evaluation instrument which collected data of the programs and services directed exclusively to the aged population, such as: senior centers, foster homes, institutions, independent living, employed and/or volunteer people, geriatric services, adult education (literacy), recreation, discounts, corporations and/or associations that benefit the aged population, aging offices, support groups, social services, home meal services, and financial aid. Data was also collected from programs and services that benefit diverse aged populations in areas such as: health, housing, employment and social welfare. The sources for the collection of data were directories available to government and private agencies, telephone directories, telephone interviews, and personal visits. The municipalities were divided into two zones, the Northern zone, constituted by 40 municipalities and the Southern zone, constituted by 38 municipalities, for a total of 78 evaluated municipalities. In the Northern region, which accounted to approximately 295,938 aged persons, 18 types of programs or services were found to serve the aged population directly and 50 types were aged-related programs or services. In the Southern region, which accounted for approximately 169,798 aged persons, 13 types of programs or services served the aged exclusively and 43 were aged-related services. The following were among the principal programs or services available: senior centers, foster homes and/or institutions, employment programs, home care services and hospices, independent living, and agricultural extension services. Among the least available programs or services were private home meal services, literacy and retraining, arts and travel services, corporations or associations for the benefit of the aged

  2. Analysis of competition program "Аcrobatics" of skilled athletes in acrobatic rock and roll

    Directory of Open Access Journals (Sweden)

    Batieieva N.P.

    2013-06-01

    Full Text Available Reviewed and analyzed the results of the strongest performances of dancing couples in acrobatic rock and roll category "M-class", the competition rules of the World rock 'n' roll confederation. A comparative analysis on the requirements to perform acrobatic competition program "Acrobatics". Selected a number of acrobatic elements that make up the structure of competitive acrobatic programs. Found that a number of sports pairs allow technical errors (involuntary distortion performance techniques acrobatic element when performing acrobatic elements. Proposed grading scale acrobatic elements of the program, using methodical and special terms "related" sports. The recommendations to judges, coaches on the cost of each acrobatic element in assessing and compiling competitive program.

  3. Design of Standards and Labeling programs in Chile: Techno-Economic Analysis for Refrigerators

    Energy Technology Data Exchange (ETDEWEB)

    Letschert, Virginie E. [Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States). Environmental Energy Technologies Division.; McNeil, Michael A. [Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States). Environmental Energy Technologies Division.; Pavon, Mariana [Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States). Environmental Energy Technologies Division.; Lutz, Wolfgang F. [Lawrence Berkeley National Laboratory (LBNL), Berkeley, CA (United States). Environmental Energy Technologies Division.

    2013-05-01

    Lawrence Berkeley National Laboratory is a global leader in the study of energy efficiency and its effective implementation through government policy. The Energy Analysis and Environmental Impacts Department of LBNL’s Environmental Energy Technologies Division provides technical assistance to help federal, stat e and local government agencies in the United States, and throughout the world, develop long-term strategies, policy, and programs to encourage energy efficiency in all sectors and industries. In the past, LBNL has assisted staff of various countries government agencies and their con tractors in providing methodologies to analyze cost-effectiveness of regulations and asses s overall national impacts of efficiency programs. The paper presents the work done in collaboration with the Ministry of Energy (MoE) in Chile and the Collaborative Labeling Appliance Standards Programs (CLASP) on designing a Minimum Energy Performance Standards (MEPS) and ext ending the current labeling program for refrigerators.

  4. Dynamic analysis for solid waste management systems: an inexact multistage integer programming approach.

    Science.gov (United States)

    Li, Yongping; Huang, Guohe

    2009-03-01

    In this study, a dynamic analysis approach based on an inexact multistage integer programming (IMIP) model is developed for supporting municipal solid waste (MSW) management under uncertainty. Techniques of interval-parameter programming and multistage stochastic programming are incorporated within an integer-programming framework. The developed IMIP can deal with uncertainties expressed as probability distributions and interval numbers, and can reflect the dynamics in terms of decisions for waste-flow allocation and facility-capacity expansion over a multistage context. Moreover, the IMIP can be used for analyzing various policy scenarios that are associated with different levels of economic consequences. The developed method is applied to a case study of long-term waste-management planning. The results indicate that reasonable solutions have been generated for binary and continuous variables. They can help generate desired decisions of system-capacity expansion and waste-flow allocation with a minimized system cost and maximized system reliability.

  5. Towards program theory validation: Crowdsourcing the qualitative analysis of participant experiences.

    Science.gov (United States)

    Harman, Elena; Azzam, Tarek

    2018-02-01

    This exploratory study examines a novel tool for validating program theory through crowdsourced qualitative analysis. It combines a quantitative pattern matching framework traditionally used in theory-driven evaluation with crowdsourcing to analyze qualitative interview data. A sample of crowdsourced participants are asked to read an interview transcript and identify whether program theory components (Activities and Outcomes) are discussed and to highlight the most relevant passage about that component. The findings indicate that using crowdsourcing to analyze qualitative data can differentiate between program theory components that are supported by a participant's experience and those that are not. This approach expands the range of tools available to validate program theory using qualitative data, thus strengthening the theory-driven approach. Copyright © 2017 Elsevier Ltd. All rights reserved.

  6. A program of computer-aided coordination analysis for an undergraduate course in protective relaying

    Energy Technology Data Exchange (ETDEWEB)

    Chu, W.C.; Liu, M.C. (Tatung Inst. of Tech., Taipei (Taiwan, Province of China))

    1992-11-01

    This paper introduces a program used as a practicing tool for the protective relaying course of undergraduate level. This progress allows students to practice protective devices coordination in power systems on a personal computer by representing the time-current curve with dynamic computer graphics. The program is also provided with a debugging system that is designed to inform the user of any problem found in his protection scheme. In order to make students fully understand the dynamic performance of protective devices coordination, the program allows students to assign the location of a fault and it will display the operating time of the protective devices according to the tripping sequence. The program also has the function of automatic coordination analysis, the results of which can be compared with the user's scheme and can also help the user to have a better understanding of what are actually used in the industry today.

  7. A Meta-analysis of the Effectiveness of Interactive Middle School Cannabis Prevention Programs.

    Science.gov (United States)

    Lize, Steven E; Iachini, Aidyn L; Tang, Weizhou; Tucker, Joshua; Seay, Kristen D; Clone, Stephanie; DeHart, Dana; Browne, Teri

    2017-01-01

    This meta-analysis examines the effectiveness of interactive middle school-based drug prevention programs on adolescent cannabis use in North America, as well as program characteristics that could moderate these effects. Interactive programs, compared to more didactic, lecture style programs, involve participants in skill-building activities and focus on interaction among participants. A systematic literature search was conducted for English-language studies from January 1998 to March 2014. Studies included evaluations using random assignment or a quasi-experimental design of interactive school-based substance use prevention programs delivered to adolescents (aged 12-14) in North American middle schools (grades 6-8). Data were extracted using a coding protocol. The outcomes of interest were post-treatment cannabis use, intent to use, and refusal skills compared across intervention and control groups. Effect sizes (Cohen's d) were calculated from continuous measures, and dichotomous measures were converted to the d index. A total of 30 studies yielding 23 independent samples were included. The random effects pooled effect size for cannabis use (k = 21) was small ([Formula: see text]= -0.07, p skills (k = 3) were not significant. Moderator analyses indicated significant differences in program effectiveness between instructor types, with teachers found to be most effective ([Formula: see text]= -0.08, p = 0.02). The findings provide further support for the use of interactive school-based programs to prevent cannabis use among middle school students in North America.

  8. An Analysis of the Geothermal Energy Extraction and Utilization Technology R&D Program

    Energy Technology Data Exchange (ETDEWEB)

    Nguyen, Van Thanh; Dhillon, Harpal S.

    1979-05-01

    The Division of Geothermal Energy (DGE) in the Department of Energy is currently reviewing its RD&D programs to evaluate their relevance to the national goals for the development of geothermal energy during the next 22 years. This report presents the results of an analysis of the RD&D program for geothermal energy extraction and conversion technology. A review of the state-of-the-art was conducted to identify opportunities for improvement. The current RDBD program was checked against the opportunities for improvement to determine if any potential improvements are being ignored, Finally, a benefit/cost analysis was conducted by estimating the benefits expected to result from successful completion of various projects.

  9. Strengthening prevention program theories and evaluations: contributions from social network analysis.

    Science.gov (United States)

    Gest, Scott D; Osgood, D Wayne; Feinberg, Mark E; Bierman, Karen L; Moody, James

    2011-12-01

    A majority of school-based prevention programs target the modification of setting-level social dynamics, either explicitly (e.g., by changing schools' organizational, cultural or instructional systems that influence children's relationships), or implicitly (e.g., by altering behavioral norms designed to influence children's social affiliations and interactions). Yet, in outcome analyses of these programs, the rich and complicated set of peer network dynamics is often reduced to an aggregation of individual characteristics or assessed with methods that do not account for the interdependencies of network data. In this paper, we present concepts and analytic methods from the field of social network analysis and illustrate their great value to prevention science--both as a source of tools for refining program theories and as methods that enable more sophisticated and focused tests of intervention effects. An additional goal is to inform discussions of the broader implications of social network analysis for public health efforts.

  10. Effectiveness of disease-management programs for improving diabetes care: a meta-analysis.

    Science.gov (United States)

    Pimouguet, Clément; Le Goff, Mélanie; Thiébaut, Rodolphe; Dartigues, Jean François; Helmer, Catherine

    2011-02-08

    We conducted a meta-analysis of randomized controlled trials to assess the effectiveness of disease-management programs for improving glycemic control in adults with diabetes mellitus and to study which components of programs are associated with their effectiveness. We searched several databases for studies published up to December 2009. We included randomized controlled trials involving adults with type 1 or 2 diabetes that evaluated the effect of disease-management programs on glycated hemoglobin (hemoglobin A₁(C)) concentrations. We performed a meta-regression analysis to determine the effective components of the programs. We included 41 randomized controlled trials in our review. Across these trials, disease-management programs resulted in a significant reduction in hemoglobin A₁(C) levels (pooled standardized mean difference between intervention and control groups -0.38 [95% confidence interval -0.47 to -0.29], which corresponds to an absolute mean difference of 0.51%). The finding was robust in the sensitivity analyses based on quality assessment. Programs in which the disease manager was able to start or modify treatment with or without prior approval from the primary care physician resulted in a greater improvement in hemoglobin A₁(C) levels (standardized mean difference -0.60 v. -0.28 in trials with no approval to do so; p management programs had a clinically moderate but significant impact on hemoglobin A₁(C) levels among adults with diabetes. Effective components of programs were a high frequency of patient contact and the ability for disease managers to adjust treatment with or without prior physician approval.

  11. TOF plotter—a program to perform routine analysis time-of-flight mass spectral data

    Science.gov (United States)

    Knippel, Brad C.; Padgett, Clifford W.; Marcus, R. Kenneth

    2004-03-01

    The main article discusses the operation and application of the program to mass spectral data files. This laboratory has recently reported the construction and characterization of a linear time-of-flight mass spectrometer (ToF-MS) utilizing a radio frequency glow discharge ionization source. Data acquisition and analysis was performed using a digital oscilloscope and Microsoft Excel, respectively. Presently, no software package is available that is specifically designed for time-of-flight mass spectral analysis that is not instrument dependent. While spreadsheet applications such as Excel offer tremendous utility, they can be cumbersome when repeatedly performing tasks which are too complex or too user intensive for macros to be viable. To address this situation and make data analysis a faster, simpler task, our laboratory has developed a Microsoft Windows-based software program coded in Microsoft Visual Basic. This program enables the user to rapidly perform routine data analysis tasks such as mass calibration, plotting and smoothing on x- y data sets. In addition to a suite of tools for data analysis, a number of calculators are built into the software to simplify routine calculations pertaining to linear ToF-MS. These include mass resolution, ion kinetic energy and single peak identification calculators. A detailed description of the software and its associated functions is presented followed by a characterization of its performance in the analysis of several representative ToF-MS spectra obtained from different GD-ToF-MS systems.

  12. An Analysis of Problems in College Students' Participation in the Western China Program

    Science.gov (United States)

    Yumei, Yi

    2008-01-01

    Since its initiation in 2003, the College Student Western China Program has had several satisfying achievements. At the same time, however, problems exist in the project. This article gives a brief analysis of problems encountered in the project from the aspects of publicity and campaign work, plans and schedules, student participation, voluntary…

  13. Applications of Combinatorial Programming to Data Analysis: The Traveling Salesman and Related Problems

    Science.gov (United States)

    Hubert, Lawrence J.; Baker, Frank B.

    1978-01-01

    The "Traveling Salesman" and similar combinatorial programming tasks encountered in operations research are discussed as possible data analysis models in psychology, for example, in developmental scaling, Guttman scaling, profile smoothing, and data array clustering. A short overview of various computational approaches from this area of…

  14. Applied Behavior Analysis Programs for Autism: Sibling Psychosocial Adjustment during and Following Intervention Use

    Science.gov (United States)

    Cebula, Katie R.

    2012-01-01

    Psychosocial adjustment in siblings of children with autism whose families were using a home-based, applied behavior analysis (ABA) program was compared to that of siblings in families who were not using any intensive autism intervention. Data gathered from parents, siblings and teachers indicated that siblings in ABA families experienced neither…

  15. Analysis of Large- Capacity Water Heaters in Electric Thermal Storage Programs

    Energy Technology Data Exchange (ETDEWEB)

    Cooke, Alan L. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Anderson, David M. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Winiarski, David W. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Carmichael, Robert T. [Cadeo Group, Washington D. C. (United States); Mayhorn, Ebony T. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Fisher, Andrew R. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2015-03-17

    This report documents a national impact analysis of large tank heat pump water heaters (HPWH) in electric thermal storage (ETS) programs and conveys the findings related to concerns raised by utilities regarding the ability of large-tank heat pump water heaters to provide electric thermal storage services.

  16. [Application of the mixed programming with Labview and Matlab in biomedical signal analysis].

    Science.gov (United States)

    Yu, Lu; Zhang, Yongde; Sha, Xianzheng

    2011-01-01

    This paper introduces the method of mixed programming with Labview and Matlab, and applies this method in a pulse wave pre-processing and feature detecting system. The method has been proved suitable, efficient and accurate, which has provided a new kind of approach for biomedical signal analysis.

  17. Vehicle technologies heavy vehicle program : FY 2008 benefits analysis, methodology and results --- final report.

    Energy Technology Data Exchange (ETDEWEB)

    Singh, M.; Energy Systems; TA Engineering

    2008-02-29

    This report describes the approach to estimating the benefits and analysis results for the Heavy Vehicle Technologies activities of the Vehicle Technologies (VT) Program of EERE. The scope of the effort includes: (1) Characterizing baseline and advanced technology vehicles for Class 3-6 and Class 7 and 8 trucks, (2) Identifying technology goals associated with the DOE EERE programs, (3) Estimating the market potential of technologies that improve fuel efficiency and/or use alternative fuels, and (4) Determining the petroleum and greenhouse gas emissions reductions associated with the advanced technologies. In FY 08 the Heavy Vehicles program continued its involvement with various sources of energy loss as compared to focusing more narrowly on engine efficiency and alternative fuels. These changes are the result of a planning effort that first occurred during FY 04 and was updated in the past year. (Ref. 1) This narrative describes characteristics of the heavy truck market as they relate to the analysis, a description of the analysis methodology (including a discussion of the models used to estimate market potential and benefits), and a presentation of the benefits estimated as a result of the adoption of the advanced technologies. The market penetrations are used as part of the EERE-wide integrated analysis to provide final benefit estimates reported in the FY08 Budget Request. The energy savings models are utilized by the VT program for internal project management purposes.

  18. Instrument and Survey Analysis Technical Report: Program Implementation Survey. Technical Report #1112

    Science.gov (United States)

    Alonzo, Julie; Tindal, Gerald

    2011-01-01

    This technical document provides guidance to educators on the creation and interpretation of survey instruments, particularly as they relate to an analysis of program implementation. Illustrative examples are drawn from a survey of educators related to the use of the easyCBM learning system. This document includes specific sections on…

  19. 10 CFR 70.62 - Safety program and integrated safety analysis.

    Science.gov (United States)

    2010-01-01

    ... to the technology of the process, and information pertaining to the equipment in the process. (c... have experience in nuclear criticality safety, radiation safety, fire safety, and chemical process... this safety program; namely, process safety information, integrated safety analysis, and management...

  20. Reassessing the Skills Required of Graduates of an Information Systems Program: An Updated Analysis

    Science.gov (United States)

    Legier, John; Woodward, Belle; Martin, Nancy

    2013-01-01

    The study involves an updated analysis of the job characteristics of information systems graduates based on the status of the job market as well as the perceptions of 72 graduates from an information systems program of a Midwestern university. Approximately one-third of the graduates were working in positions related to technical support.…

  1. 78 FR 6140 - Discount Rates for Cost-Effectiveness Analysis of Federal Programs

    Science.gov (United States)

    2013-01-29

    ... BUDGET Discount Rates for Cost-Effectiveness Analysis of Federal Programs AGENCY: Office of Management... and Budget revised Circular A-94 in 1992. The revised Circular specified certain discount rates to be... States Government were changed. These discount rates are found in Appendix C of the revised Circular. The...

  2. 77 FR 1743 - Discount Rates for Cost-Effectiveness Analysis of Federal Programs

    Science.gov (United States)

    2012-01-11

    ... BUDGET Discount Rates for Cost-Effectiveness Analysis of Federal Programs AGENCY: Office of Management... and Budget revised Circular A-94 in 1992. The revised Circular specified certain discount rates to be... States Government were changed. These discount rates are found in Appendix C of the revised Circular. The...

  3. 76 FR 7881 - Discount Rates for Cost-Effectiveness Analysis of Federal Programs

    Science.gov (United States)

    2011-02-11

    ... BUDGET Discount Rates for Cost-Effectiveness Analysis of Federal Programs AGENCY: Office of Management... and Budget revised Circular A-94 in 1992. The revised Circular specified certain discount rates to be... States Government were changed. These discount rates are found in Appendix C of the revised Circular. The...

  4. Puerto Rico's forest inventory: adapting the forest inventory and analysis program to a Caribbean island.

    Science.gov (United States)

    T. J. Brandeis

    2003-01-01

    Rapid Changes in vegetation over short distances, high species diversity, and fragmented landscape challege the implementation of the Forest service's Forest inventory and Analysis (FIA)program on Puerto Rico. Applying the hexagonal FIA grid as used on the continental United States, the Forest service is installing a new forest sampling and monitoring framework...

  5. The forest inventory and analysis program: what's in it for landowners?

    Science.gov (United States)

    Richard Harper

    2009-01-01

    In 1597, Sir Francis Bacon coined the phrase, "Knowledge is power." KnOwledge today often means knowing where to find reliable information from branded research sources. One such source that benefits forest landowners and the forest community is the Forest Inventory and Analysis (FIA) program.

  6. Specifications of the equations for LEAP Model 22C. [Long-Term Energy Analysis Program

    Energy Technology Data Exchange (ETDEWEB)

    Goldstein, M.; Alsmiller, R.G. Jr.; Barish, J.

    1981-03-01

    This report describes the equations implemented in the Long-Term Energy Analysis Program (LEAP) Model 22C. The equilibrium equations of each of the processes contained in the LEAP Model 22C are specified, and the interrelations of the various equations are discussed. No attempt is made to derive the equations or to discuss their validity from an economic point of view.

  7. WINDOWS: a program for the analysis of spectral data foil activation measurements

    Energy Technology Data Exchange (ETDEWEB)

    Stallmann, F.W.; Eastham, J.F.; Kam, F.B.K.

    1978-12-01

    The computer program WINDOWS together with its subroutines is described for the analysis of neutron spectral data foil activation measurements. In particular, the unfolding of the neutron differential spectrum, estimated windows and detector contributions, upper and lower bounds for an integral response, and group fluxes obtained from neutron transport calculations. 116 references. (JFP)

  8. Analysis of Evidence Supporting the Educational Leadership Constituent Council 2011 Educational Leadership Program Standards

    Science.gov (United States)

    Tucker, Pamela D.; Anderson, Erin; Reynolds, Amy L.; Mawhinney, Hanne

    2016-01-01

    This document analysis provides a summary of the research from high-impact journals published between 2008 and 2013 with the explicit purpose of determining the extent to which the current empirical evidence supports the individual 2011 Educational Leadership Constituent Council Program Standards and their elements. We found that the standards are…

  9. STARS: An Integrated, Multidisciplinary, Finite-Element, Structural, Fluids, Aeroelastic, and Aeroservoelastic Analysis Computer Program

    Science.gov (United States)

    Gupta, K. K.

    1997-01-01

    A multidisciplinary, finite element-based, highly graphics-oriented, linear and nonlinear analysis capability that includes such disciplines as structures, heat transfer, linear aerodynamics, computational fluid dynamics, and controls engineering has been achieved by integrating several new modules in the original STARS (STructural Analysis RoutineS) computer program. Each individual analysis module is general-purpose in nature and is effectively integrated to yield aeroelastic and aeroservoelastic solutions of complex engineering problems. Examples of advanced NASA Dryden Flight Research Center projects analyzed by the code in recent years include the X-29A, F-18 High Alpha Research Vehicle/Thrust Vectoring Control System, B-52/Pegasus Generic Hypersonics, National AeroSpace Plane (NASP), SR-71/Hypersonic Launch Vehicle, and High Speed Civil Transport (HSCT) projects. Extensive graphics capabilities exist for convenient model development and postprocessing of analysis results. The program is written in modular form in standard FORTRAN language to run on a variety of computers, such as the IBM RISC/6000, SGI, DEC, Cray, and personal computer; associated graphics codes use OpenGL and IBM/graPHIGS language for color depiction. This program is available from COSMIC, the NASA agency for distribution of computer programs.

  10. Systematic Review and Meta-Analysis of the "Skills for Social and Academic Success" ("SASS") Program

    Science.gov (United States)

    Mychailyszyn, Matthew P.

    2017-01-01

    The purpose of this systematic review and meta-analysis was to synthesize the available research on the "Skills for Social and Academic Success" ("SASS") program, a school-based cognitive/behavioural intervention for adolescents with social anxiety disorder. A search of online databases, combined with reference list examination…

  11. Identifying Barriers in Implementing Outcomes-Based Assessment Program Review: A Grounded Theory Analysis

    Science.gov (United States)

    Bresciani, Marilee J.

    2011-01-01

    The purpose of this grounded theory study was to identify the typical barriers encountered by faculty and administrators when implementing outcomes-based assessment program review. An analysis of interviews with faculty and administrators at nine institutions revealed a theory that faculty and administrators' promotion, tenure (if applicable),…

  12. An Analysis of the Reading Mastery Program: Effective Components and Research Review.

    Science.gov (United States)

    Schieffer, Cheryl; Marchand-Martella, Nancy E.; Martella, Ronald C.; Simonsen, Flint L.; Waldron-Soler, Kathleen M.

    2002-01-01

    Provides an analysis of the Reading Mastery program that includes an overview of the need to teach reading. Examines how Reading Mastery aligns with the focal areas of oral language, decoding, and comprehension. Details a comprehensive research review of 25 published studies and two large-scale research reviews. Finds use of the Reading Mastery…

  13. School Programs Targeting Stress Management in Children and Adolescents: A Meta-Analysis

    Science.gov (United States)

    Kraag, Gerda; Zeegers, Maurice P.; Kok, Gerjo; Hosman, Clemens; Abu-Saad, Huda Huijer

    2006-01-01

    Introduction: This meta-analysis evaluates the effect of school programs targeting stress management or coping skills in school children. Methods: Articles were selected through a systematic literature search. Only randomized controlled trials or quasi-experimental studies were included. The standardized mean differences (SMDs) between baseline…

  14. Effectiveness of the triple P positive parenting program on parenting: A meta-analysis

    NARCIS (Netherlands)

    Graaf, I. de; Speetjens, P.; Smit, F.; Wolff, M. de; Tavecchio, L.

    2008-01-01

    Triple P is a parenting program intended to prevent and to provide treatment for severe behavioral, emotional, and developmental problems in children. The aim of this meta-analysis was to assess the effectiveness of Triple P Level 4 interventions on parenting styles and parental competency. Level 4

  15. Competing definitions: a public policy analysis of the federal recreational fee demonstration program

    Science.gov (United States)

    Thomas A. E. More

    2003-01-01

    Problem definition theory specifies that however controls the definition of a problem is in a unique position to control debate over the issue, influence others, and determine the problem's place on the agenda. This paper uses a rhetorical analysis and a questionnaire survey of congressional aides to examine the federal Recreational Fee Demonstration Program....

  16. The soil indicator of forest health in the Forest Inventory and Analysis Program

    Science.gov (United States)

    Michael C. Amacher; Charles H. Perry

    2010-01-01

    Montreal Process Criteria and Indicators (MPCI) were established to monitor forest conditions and trends to promote sustainable forest management. The Soil Indicator of forest health was developed and implemented within the USFS Forest Inventory and Analysis (FIA) program to assess condition and trends in forest soil quality in U.S. forests regardless of ownership. The...

  17. Age 26 Cost-Benefit Analysis of the Child-Parent Center Early Education Program

    Science.gov (United States)

    Reynolds, Arthur J.; Temple, Judy A.; White, Barry A. B.; Ou, Suh-Ruu; Robertson, Dylan L.

    2011-01-01

    Using data collected up to age 26 in the Chicago Longitudinal Study, this cost-benefit analysis of the Child-Parent Centers (CPC) is the first for a sustained publicly funded early intervention. The program provides services for low-income families beginning at age 3 in 20 school sites. Kindergarten and school-age services are provided up to age 9…

  18. Statistical analysis on the factors affecting agricultural landowners’ willingness to enroll in a tree planting program

    Science.gov (United States)

    Taeyoung Kim; Christian. Langpap

    2015-01-01

    This report provides a statistical analysis of the data collected from two survey regions of the United States, the Pacific Northwest and the Southeast. The survey asked about individual agricultural landowners’ characteristics, characteristics of their land, and the landowners’ willingness to enroll in a tree planting program under incentive payments for carbon...

  19. Technical efficiency of women's health prevention programs in Bucaramanga, Colombia: a four-stage analysis.

    Science.gov (United States)

    Ruiz-Rodriguez, Myriam; Rodriguez-Villamizar, Laura A; Heredia-Pi, Ileana

    2016-10-13

    Primary Health Care (PHC) is an efficient strategy to improve health outcomes in populations. Nevertheless, studies of technical efficiency in health care have focused on hospitals, with very little on primary health care centers. The objective of the present study was to use the Data Envelopment Analysis to estimate the technical efficiency of three women's health promotion and disease prevention programs offered by primary care centers in Bucaramanga, Colombia. Efficiency was measured using a four-stage data envelopment analysis with a series of Tobit regressions to account for the effect of quality outcomes and context variables. Input/output information was collected from the institutions' records, chart reviews and personal interviews. Information about contextual variables was obtained from databases from the primary health program in the municipality. A jackknife analysis was used to assess the robustness of the results. The analysis was based on data from 21 public primary health care centers. The average efficiency scores, after adjusting for quality and context, were 92.4 %, 97.5 % and 86.2 % for the antenatal care (ANC), early detection of cervical cancer (EDCC) and family planning (FP) programs, respectively. On each program, 12 of the 21 (57.1 %) health centers were found to be technically efficient; having had the best-practice frontiers. Adjusting for context variables changed the scores and reference rankings of the three programs offered by the health centers. The performance of the women's health prevention programs offered by the centers was found to be heterogeneous. Adjusting for context and health care quality variables had a significant effect on the technical efficiency scores and ranking. The results can serve as a guide to strengthen management and organizational and planning processes related to local primary care services operating within a market-based model such as the one in Colombia.

  20. An Irish Cross-Institutional User Needs Analysis of Undergraduate Programming

    Directory of Open Access Journals (Sweden)

    Eileen Mary Costelloe

    2006-07-01

    Full Text Available Research literature and practical experience of subject experts indicate that teaching programming to novices has proven challenging for both learner and lecturer. A number of difficulties arise when teaching novices to program. These ranges from the inadequacy of the undergraduate students’ problem-solving skills, problems with understanding programming constructs, to the complexity of the environments in which the students develop their solutions. This paper outlines a project which aims to address some of the challenges faced by novice programmers by providing them with an innovative learning tool, incorporating a set of Reusable Learning Objects (RLOs, based on sound pedagogical principles and encapsulated in a Constructivist Learning Environment (CLE. The Learning Objects will focus on the common areas of weaknesses that are determined by an Irish cross-institutional User Needs Analysis. The initial research activity was to conduct a User Needs Analysis, which was carried out in the three third level academic partner institutions and which will inform and direct the remainder of the research project. The User Needs Analysis confirmed that first year undergraduate students find programming the most challenging module they study. Programming constructs such as Arrays, Looping and Selection were shown to be the most problematic in semester one, and Methods and Polymorphism posing difficulties in semester two. Interestingly the students’ actual and perceived difficulties with the concepts were not in-line, with the students perceiving their difficulties to be less than they actually were. The students acknowledge that problem-solving abilities impacted on their performance but only 20% of students in one college admitted to thinking about their approach in designing programming solutions. The results of the User Needs Analysis directs the design and development of the RLOs and the learning tool.

  1. A Cost Analysis Study of the Radiography Program at Middlesex Hospital Using Shock's Analysis Model.

    Science.gov (United States)

    Spence, Weymouth

    Federal and state governments want to decrease payments for medical education, and other payers are trying to restrict payouts to direct and necessary patient care services. Teaching hospitals are increasing tuition and fees, reducing education budgets and, in many instances, closing education programs. Hospital administrators are examining the…

  2. Numeric Program Analysis Techniques with Applications to Array Analysis and Library Summarization

    Science.gov (United States)

    2007-01-01

    importance for the areas of software engineering, soft - ware verification, and security: to identify many program errors, such as out-of-bounds array...ification language with primitives for specifying numeric conditional expressions in logic formu- lae , and for specifying numeric updates in TVLA

  3. FIRE: an SPSS program for variable selection in multiple linear regression analysis via the relative importance of predictors

    National Research Council Canada - National Science Library

    Lorenzo-Seva, Urbano; Ferrando, Pere J

    2011-01-01

    We provide an SPSS program that implements currently recommended techniques and recent developments for selecting variables in multiple linear regression analysis via the relative importance of predictors...

  4. Review and analysis of the 1980-1989 biomass thermochemical conversion program

    Energy Technology Data Exchange (ETDEWEB)

    Stevens, D.J.

    1994-09-01

    In the period between 1980 and 1989, the U.S. Department of Energy (DOE) sponsored research and development projects through its Biomass Thermochemical Conversion (BTC) Program. Thermochemical conversion technologies use elevated temperatures to convert biomass into more useful forms of energy such as fuel gases or transportation fuels. The BTC Program included a wide range of biomass conversion projects in the areas of gasification, pyrolysis, liquefaction, and combustion. This work formed the basis of the present DOE research and development efforts on advanced liquid fuel and power generation systems. At the beginning of Fiscal Year 1989, the management of the BTC Program was transferred from Pacific Northwest Laboratory (PNL) to National Renewable Energy Laboratory (NREL, formerly Solar Energy Research Institute). This document presents a summary of the research which was performed under the BTC Program during the 1981-1989 time frame. The document consists of an analysis of the research projects which were funded by the BTC Program and a bibliography of published documents. This work will help ensure that information from PNL`s BTC Program is available to those interested in biomass conversion technologies. The background of the BTC Program is discussed in the first chapter of this report. In addition, a brief summary of other related biomass research and development programs funded by the U.S. Department of Energy and others is presented with references where additional information can be found. The remaining chapters of the report present a detailed summary of the research projects which were funded by the BTC Program. The progress which was made on each project is summarized, the overall impact on biomass conversion is discussed, and selected references are provided.

  5. CRITIC2: A program for real-space analysis of quantum chemical interactions in solids

    Science.gov (United States)

    Otero-de-la-Roza, A.; Johnson, Erin R.; Luaña, Víctor

    2014-03-01

    We present CRITIC2, a program for the analysis of quantum-mechanical atomic and molecular interactions in periodic solids. This code, a greatly improved version of the previous CRITIC program (Otero-de-la Roza et al., 2009), can: (i) find critical points of the electron density and related scalar fields such as the electron localization function (ELF), Laplacian, … (ii) integrate atomic properties in the framework of Bader’s Atoms-in-Molecules theory (QTAIM), (iii) visualize non-covalent interactions in crystals using the non-covalent interactions (NCI) index, (iv) generate relevant graphical representations including lines, planes, gradient paths, contour plots, atomic basins, … and (v) perform transformations between file formats describing scalar fields and crystal structures. CRITIC2 can interface with the output produced by a variety of electronic structure programs including WIEN2k, elk, PI, abinit, Quantum ESPRESSO, VASP, Gaussian, and, in general, any other code capable of writing the scalar field under study to a three-dimensional grid. CRITIC2 is parallelized, completely documented (including illustrative test cases) and publicly available under the GNU General Public License. Catalogue identifier: AECB_v2_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AECB_v2_0.html Program obtainable from: CPC Program Library, Queen’s University, Belfast, N. Ireland Licensing provisions: yes No. of lines in distributed program, including test data, etc.: 11686949 No. of bytes in distributed program, including test data, etc.: 337020731 Distribution format: tar.gz Programming language: Fortran 77 and 90. Computer: Workstations. Operating system: Unix, GNU/Linux. Has the code been vectorized or parallelized?: Shared-memory parallelization can be used for most tasks. Classification: 7.3. Catalogue identifier of previous version: AECB_v1_0 Journal reference of previous version: Comput. Phys. Comm. 180 (2009) 157 Nature of problem: Analysis of quantum

  6. SWOT analysis: strengths, weaknesses, opportunities and threats of the Israeli Smallpox Revaccination Program.

    Science.gov (United States)

    Huerta, Michael; Balicer, Ran D; Leventhal, Alex

    2003-01-01

    During September 2002, Israel began its current revaccination program against smallpox, targeting previously vaccinated "first responders" among medical and emergency workers. In order to identify the potential strengths and weaknesses of this program and the conditions under which critical decisions were reached, we conducted a SWOT analysis of the current Israeli revaccination program, designed to identify its intrinsic strengths and weaknesses, as well as opportunities for its success and threats against it. SWOT analysis--a practical tool for the study of public health policy decisions and the social and political contexts in which they are reached--revealed clear and substantial strengths and weaknesses of the current smallpox revaccination program, intrinsic to the vaccine itself. A number of threats were identified that may jeopardize the success of the current program, chief among them the appearance of severe complications of vaccination. Our finding of a lack of a generation of knowledge on smallpox vaccination highlights the need for improved physician education and dissipation of misconceptions that are prevalent in the public today.

  7. Development of Thermal Performance Analysis Computer Program on Turbine Cycle of Yoggwang 3,4 Units

    Energy Technology Data Exchange (ETDEWEB)

    Hong, S.Y.; Choi, K.H.; Jee, M.H.; Chung, S.I. [Korea Electric Power Research Institute, Taejon (Korea)

    2002-07-01

    The objective of the study ''Development of Thermal Performance Analysis Computer Program on Turbine Cycle of Yonggwang 3,4 Units'' is to utilize computerized program to the performance test of the turbine cycle or the analysis of the operational status of the thermal plants. In addition, the result can be applicable to the analysis of the thermal output at the abnormal status and be a powerful tool to find out the main problems for such cases. As a results, the output of this study can supply the way to confirm the technical capability to operate the plants efficiently and to obtain the economic gains remarkably. (author). 27 refs., 73 figs., 6 tabs.

  8. Integrated care programs for patients with psychological comorbidity: A systematic review and meta-analysis.

    Science.gov (United States)

    Lemmens, Lidwien C; Molema, Claudia C M; Versnel, Nathalie; Baan, Caroline A; de Bruin, Simone R

    2015-12-01

    Presently, little is known about the characteristics and impact of integrated care programs for patients with psychological comorbidity. The aim was to provide an overview of these integrated care programs and their effectiveness. Systematic literature review including papers published between 1995 and 2014. An integrated care program had to consist of interventions related to at least two out of the six components of the Chronic Care Model. Programs had to address patients with psychological comorbidity, which is a psychological disease next to a somatic chronic disease. A meta-analysis was performed on depression treatment response and a best evidence synthesis was performed on other outcomes. Ten programs were identified, which mostly addressed comorbid depression and consisted of interventions related to three to five components of the Chronic Care Model. Meta-analysis showed significantly higher odds for depression treatment response for patients receiving integrated care (OR: 2.49, 95%CI [1.66-3.75]). Best evidence synthesis suggested moderate evidence for cost-effectiveness and for a beneficial effect on patient satisfaction and emotional well-being. Insufficient evidence was found for a beneficial effect on health-related quality of life, medication adherence, Hb1Ac levels and mortality. There are few studies evaluating integrated care programs for patients with psychological comorbidity. Although these studies suggest that integrated care programs could positively affect several patient outcomes and could be cost-effective, additional studies are recommended to further assess the value of integrated care for this patient group. This is especially important since the number of people with psychological comorbidity is rising. Copyright © 2015 Elsevier Inc. All rights reserved.

  9. Benefit-cost analysis of Uganda's clonal coffee replanting program: An ex-ante analysis

    OpenAIRE

    Benin, Samuel; You, Liangzhi

    2007-01-01

    "The Ugandan coffee industry is facing some serious challenges, including low international prices in the international coffee market, aging coffee trees and declining productivity, and, more recently, the appearance of coffee-wilt disease, which have all contributed to the decline in both the quantity and value of coffee exports. The government of Uganda, through the Uganda Coffee Development Authority (UCDA), in 1993/94 started a coffee-replanting program to both replace coffee trees that w...

  10. INMETRO products analysis program: impact on quality of the brazilian industry

    Directory of Open Access Journals (Sweden)

    Marcos André Borges

    2008-07-01

    Full Text Available The main objective is to proceed a detailed analysis of the Products Analysis Program of Inmetro, evaluating its contribution to the suppliers of products and services. The relevance of this program - a governmental initiative financed with public resources that relates several sectors of the society – as a factor of incentive to the competitiveness of the national industry, can be evidenced by the research of the impact generated by this activity, translated in improvement actions to the analyzed products and services that aim at the correction of eventual non-conformity to the criteria set in standards and technical regulations related to health and safety. Several sectors in industry have been benefited with the creation or revision of standards, implementation of industry quality programs, voluntary or mandatory conformity assessment programs, and others. The consequences include, beyond the protection of the consumers, the increase of national industry competitiveness and domestic market strength, and the warranty of loyal competition between the suppliers. Key-words: Product Analysis, Quality, Inmetro.

  11. Optimizing national immunization program supply chain management in Thailand: an economic analysis.

    Science.gov (United States)

    Riewpaiboon, A; Sooksriwong, C; Chaiyakunapruk, N; Tharmaphornpilas, P; Techathawat, S; Rookkapan, K; Rasdjarmrearnsook, A; Suraratdecha, C

    2015-07-01

    This study aimed to conduct an economic analysis of the transition of the conventional vaccine supply and logistics systems to the vendor managed inventory (VMI) system in Thailand. Cost analysis of health care program. An ingredients based approach was used to design the survey and collect data for an economic analysis of the immunization supply and logistics systems covering procurement, storage and distribution of vaccines from the central level to the lowest level of vaccine administration facility. Costs were presented in 2010 US dollar. The total cost of the vaccination program including cost of vaccine procured and logistics under the conventional system was US$0.60 per packed volume procured (cm(3)) and US$1.35 per dose procured compared to US$0.66 per packed volume procured (cm(3)) and US$1.43 per dose procured under the VMI system. However, the findings revealed that the transition to the VMI system and outsourcing of the supply chain system reduced the cost of immunization program at US$6.6 million per year because of reduction of un-opened vaccine wastage. The findings demonstrated that the new supply chain system would result in efficiency improvement and potential savings to the immunization program compared to the conventional system. Copyright © 2015 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved.

  12. [Cost-benefit analysis of primary prevention programs for mental health at the workplace in Japan].

    Science.gov (United States)

    Yoshimura, Kensuke; Kawakami, Norito; Tsusumi, Akizumi; Inoue, Akiomi; Kobayashi, Yuka; Takeuchi, Ayano; Fukuda, Takashi

    2013-01-01

    To determine the cost-benefits of primary prevention programs for mental health at the workplace, we conducted a meta-analysis of published studies in Japan. We searched the literature, published as of 16 November 2011, using the Pubmed database and relevant key words. The inclusion criteria were: conducted in the workplace in Japan; primary prevention focus; quasi-experimental studies or controlled trials; and outcomes including absenteeism or presenteeism. Four studies were identified: one participatory work environment improvement, one individual-oriented stress management, and two supervisor education programs. Costs and benefits in yen were estimated for each program, based on the description of the programs in the literature, and additional information from the authors. The benefits were estimated based on each program's effect on work performance (measured using the WHO Health and Work Performance Questionnaire in all studies), as well as sick leave days, if available. The estimated relative increase in work performance (%) in the intervention group compared to the control group was converted into labor cost using the average bonus (18% of the total annual salary) awarded to employees in Japan as a base. Sensitive analyses were conducted using different models of time-trend of intervention effects and 95% confidence limits of the relative increase in work performance. For the participatory work environment improvement program, the cost was estimated as 7,660 yen per employee, and the benefit was 15,200-22,800 yen per employee. For the individual-oriented stress management program, the cost was 9,708 yen per employee, and the benefit was 15,200-22,920 yen per employee. For supervisor education programs, the costs and benefits were respectively 5,209 and 4,400-6,600 yen per employee, in one study, 2,949 and zero yen per employee in the other study. The 95% confidence intervals were wide for all these studies. For the point estimates based on these cases, the

  13. The enhanced forest inventory and analysis program of the USDA forest service: historical perspective and announcements of statistical documentation

    Science.gov (United States)

    Ronald E. McRoberts; William A. Bechtold; Paul L. Patterson; Charles T. Scott; Gregory A. Reams

    2005-01-01

    The Forest Inventory and Analysis (FIA) program of the USDA Forest Service has initiated a transition from regional, periodic inventories to an enhanced national FIA program featuring annual measurement of a proportion of plots in each state, greater national consistency, and integration with the ground sampling component of the Forest Health Monitoring (FHM) program...

  14. A self-capitalization model for building behavior analysis graduate programs.

    Science.gov (United States)

    Hayes, L J; Hayes, S C; Ghezzi, P M; Bijou, S W; Williams, W L; Follette, W C

    1995-01-01

    The development of the Behavior Analysis Program at the University of Nevada through self-capitalization is described. With this model, both doctoral and master's degree programs were established at almost no cost to the university. Some of the problems encountered along the way, including gaining support for the original proposal, attracting and retaining high-quality faculty, engendering support from the Department of Psychology and the university, developing resources, and balancing academic with entrepreneurial demands are discussed, as are the solutions we have found for those problems.

  15. Model-based schedulability analysis of safety critical hard real-time Java programs

    DEFF Research Database (Denmark)

    Bøgholm, Thomas; Kragh-Hansen, Henrik; Olsen, Petur

    2008-01-01

    has been implemented in a tool, named SARTS, successfully used to verify the schedulability of a real-time sorting machine consisting of two periodic and two sporadic tasks. SARTS has also been applied on a number of smaller examples to investigate properties of our approach.......In this paper, we present a novel approach to schedulability analysis of Safety Critical Hard Real-Time Java programs. The approach is based on a translation of programs, written in the Safety Critical Java profile introduced in [21] for the Java Optimized Processor [18], to timed automata models...

  16. Analysis of Participatory Photojournalism in a Widely Disseminated Skin Cancer Prevention Program

    OpenAIRE

    Hall, Dawn; Glanz, Karen; Kline, Melissa

    2010-01-01

    This article describes the content of pictures submitted to a photo contest as part of a nationally disseminated skin cancer prevention program called Pool Cool. The aims of this analysis are to describe sun-safety behaviors and environmental supports depicted in the photos and to gain insight into pool staff perceptions of the program. A directed approach was used to assess the content of 1,886 photos submitted in 2005 and 2006. Staying in the shade and applying sunscreen were the most commo...

  17. The TEACCH program for children and adults with autism: a meta-analysis of intervention studies.

    Science.gov (United States)

    Virues-Ortega, Javier; Julio, Flávia M; Pastor-Barriuso, Roberto

    2013-12-01

    The intervention program for autism known as Treatment and Education of Autistic and Related Communication Handicapped Children (TEACCH) is considered an emerging practice for autism. In the present study we used state-of-the-art meta-analytical procedures to examine the pooled clinical effects of TEACCH in a variety of outcomes. A total of 13 studies were selected for meta-analysis totaling 172 individuals with autism exposed to TEACCH. Standardized measures of perceptual, motor, adaptive, verbal and cognitive skills were identified as treatment outcomes. We used inverse-variance weighted random effects meta-analysis supplemented with quality assessment, sensitivity analysis, meta-regression, and heterogeneity and publication bias tests. The results suggested that TEACCH effects on perceptual, motor, verbal and cognitive skills were of small magnitude in the meta-analyzed studies. Effects over adaptive behavioral repertoires including communication, activities of daily living, and motor functioning were within the negligible to small range. There were moderate to large gains in social behavior and maladaptive behavior. The effects of the TEACCH program were not moderated by aspects of the intervention such as duration (total weeks), intensity (hours per week), and setting (home-based vs. center-based). While the present meta-analysis provided limited support for the TEACCH program as a comprehensive intervention, our results should be considered exploratory owing to the limited pool of studies available. © 2013.

  18. Java Programs for Using Newmark's Method and Simplified Decoupled Analysis to Model Slope Performance During Earthquakes

    Science.gov (United States)

    Jibson, Randall W.; Jibson, Matthew W.

    2003-01-01

    Landslides typically cause a large proportion of earthquake damage, and the ability to predict slope performance during earthquakes is important for many types of seismic-hazard analysis and for the design of engineered slopes. Newmark's method for modeling a landslide as a rigid-plastic block sliding on an inclined plane provides a useful method for predicting approximate landslide displacements. Newmark's method estimates the displacement of a potential landslide block as it is subjected to earthquake shaking from a specific strong-motion record (earthquake acceleration-time history). A modification of Newmark's method, decoupled analysis, allows modeling landslides that are not assumed to be rigid blocks. This open-file report is available on CD-ROM and contains Java programs intended to facilitate performing both rigorous and simplified Newmark sliding-block analysis and a simplified model of decoupled analysis. For rigorous analysis, 2160 strong-motion records from 29 earthquakes are included along with a search interface for selecting records based on a wide variety of record properties. Utilities are available that allow users to add their own records to the program and use them for conducting Newmark analyses. Also included is a document containing detailed information about how to use Newmark's method to model dynamic slope performance. This program will run on any platform that supports the Java Runtime Environment (JRE) version 1.3, including Windows, Mac OSX, Linux, Solaris, etc. A minimum of 64 MB of available RAM is needed, and the fully installed program requires 400 MB of disk space.

  19. [Analysis of the implementation of the Tuberculosis Control Program in Brazilian prisons].

    Science.gov (United States)

    Oliveira, Luisa Gonçalves Dutra de; Natal, Sonia; Camacho, Luiz Antonio Bastos

    2015-03-01

    Tuberculosis control measures in Brazil's prison population have been regulated for ten years under the National Prison Health System Plan. Brazilian states have different organizational models for the Tuberculosis Control Program (TCP) in their prison systems. This study evaluated TCP implementation in prisons in two Brazilian states, using a multiple case study design with a qualitative approach and a log-frame analysis and assessment. According to predefined criteria, two state cases were selected, with two analytical units for each case and one prison hospital in Case 2. We identified partial program implementation in the Case 1 prisons and prison hospital and low implementation in non-hospital prison health services in Case 2. Lack of financial investment and resources, lack of integration between the courts and law enforcement system and health institutions, and poor access to health services in prisons were adverse factors for program implementation.

  20. Using Curriculum Mapping to Engage Faculty Members in the Analysis of a Pharmacy Program

    Science.gov (United States)

    Vercaigne, Lavern; Davies, Neal M.; Davis, Christine; Renaud, Robert; Kristjanson, Cheryl

    2014-01-01

    Objective. To develop a curriculum mapping process that supports continuous analysis and evidence-based decisions in a pharmacy program. Design. A curriculum map based on the national educational outcomes for pharmacy programs was created using conceptual frameworks grounded in cognitive learning and skill acquisition. Assessment. The curriculum map was used to align the intended curriculum with the national educational outcomes and licensing examination blueprint. The leveling and sequencing of content showed longitudinal progression of student learning and performance. There was good concordance between the intended and learned curricula as validated by survey responses from employers and graduating students. Conclusion. The curriculum mapping process was efficient and effective in providing an evidence-based approach to the continuous quality improvement of a pharmacy program. PMID:25258444