WorldWideScience

Sample records for program acp contracts

  1. The ACP (Advanced Computer Program) multiprocessor system at Fermilab

    Energy Technology Data Exchange (ETDEWEB)

    Nash, T.; Areti, H.; Atac, R.; Biel, J.; Case, G.; Cook, A.; Fischler, M.; Gaines, I.; Hance, R.; Husby, D.

    1986-09-01

    The Advanced Computer Program at Fermilab has developed a multiprocessor system which is easy to use and uniquely cost effective for many high energy physics problems. The system is based on single board computers which cost under $2000 each to build including 2 Mbytes of on board memory. These standard VME modules each run experiment reconstruction code in Fortran at speeds approaching that of a VAX 11/780. Two versions have been developed: one uses Motorola's 68020 32 bit microprocessor, the other runs with AT and T's 32100. both include the corresponding floating point coprocessor chip. The first system, when fully configured, uses 70 each of the two types of processors. A 53 processor system has been operated for several months with essentially no down time by computer operators in the Fermilab Computer Center, performing at nearly the capacity of 6 CDC Cyber 175 mainframe computers. The VME crates in which the processing ''nodes'' sit are connected via a high speed ''Branch Bus'' to one or more MicroVAX computers which act as hosts handling system resource management and all I/O in offline applications. An interface from Fastbus to the Branch Bus has been developed for online use which has been tested error free at 20 Mbytes/sec for 48 hours. ACP hardware modules are now available commercially. A major package of software, including a simulator that runs on any VAX, has been developed. It allows easy migration of existing programs to this multiprocessor environment. This paper describes the ACP Multiprocessor System and early experience with it at Fermilab and elsewhere.

  2. Superfund Contract Laboratory Program

    Science.gov (United States)

    The Contract Laboratory Program (CLP) is a national network of EPA personnel, commercial laboratories, and support contractors whose primary mission is to provide data of known and documented quality to the Superfund program.

  3. The Joint Polar Satellite System (JPSS) Program's Algorithm Change Process (ACP): Past, Present and Future

    Science.gov (United States)

    Griffin, Ashley

    2017-01-01

    The Joint Polar Satellite System (JPSS) Program Office is the supporting organization for the Suomi National Polar Orbiting Partnership (S-NPP) and JPSS-1 satellites. S-NPP carries the following sensors: VIIRS, CrIS, ATMS, OMPS, and CERES with instruments that ultimately produce over 25 data products that cover the Earths weather, oceans, and atmosphere. A team of scientists and engineers from all over the United States document, monitor and fix errors in operational software code or documentation with the algorithm change process (ACP) to ensure the success of the S-NPP and JPSS 1 missions by maintaining quality and accuracy of the data products the scientific community relies on. This poster will outline the programs algorithm change process (ACP), identify the various users and scientific applications of our operational data products and highlight changes that have been made to the ACP to accommodate operating system upgrades to the JPSS programs Interface Data Processing Segment (IDPS), so that the program is ready for the transition to the 2017 JPSS-1 satellite mission and beyond.

  4. Meadow enriched ACP process algebras

    NARCIS (Netherlands)

    Bergstra, J.A.; Middelburg, C.A.

    2009-01-01

    We introduce the notion of an ACP process algebra. The models of the axiom system ACP are the origin of this notion. ACP process algebras have to do with processes in which no data are involved. We also introduce the notion of a meadow enriched ACP process algebra, which is a simple generalization

  5. Measuring Satisfaction in the Program Manager, Procuring Contracting Officer Relationship

    Science.gov (United States)

    1997-12-01

    Contracting Officer) and one of her customers (a U. S. Navy Program Manager ). From an examination of this relationship , the most appropriate criteria... Customer Satisfaction, Performance Measurement, Metrics, Contracting, Program Management 17. SECURITY CLASSIFICATION OF REPORT Unclassified...methodology for developing an instrument to measure the satisfaction of their customers , Navy Program Managers . The purpose of this thesis was to develop

  6. Measuring Satisfaction in the Program Manager, Procuring Contracting Officer Relationship

    National Research Council Canada - National Science Library

    Gray, John

    1997-01-01

    .... To comply with this Executive Order, Navy contracting offices require an effective methodology for developing an instrument to measure the satisfaction of their customers, Navy Program Managers...

  7. Notification: Review of the Contract Management Assessment Program

    Science.gov (United States)

    Project #OA-FY14-0034, October 30, 2013. The Office of Inspector General plans to begin the preliminary research phase of an audit evaluating the Office of Acquisition Management’s Contract Management Assessment Program (CMAP).

  8. 48 CFR 301.607-78 - Contracting Officer designation of a Program/Project Manager as the Contracting Officer's...

    Science.gov (United States)

    2010-10-01

    ... designation of a Program/Project Manager as the Contracting Officer's Technical Representative. 301.607-78... Contracting Officer designation of a Program/Project Manager as the Contracting Officer's Technical... acquisition. However, for those individuals serving as a Program or Project Manager under a FAC-P/PM...

  9. 7 CFR 701.45 - Forestry Incentives Program (FIP) contracts.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false Forestry Incentives Program (FIP) contracts. 701.45 Section 701.45 Agriculture Regulations of the Department of Agriculture (Continued) FARM SERVICE AGENCY... RELATED PROGRAMS PREVIOUSLY ADMINISTERED UNDER THIS PART § 701.45 Forestry Incentives Program (FIP...

  10. Contractions

    Science.gov (United States)

    ... body for labor and delivery. Labor contractions signal the beginning of childbirth. What causes contractions? Braxton-Hicks (false ... of your last menstrual period.) Labor contractions signal the beginning of childbirth. These contractions come at regular intervals, ...

  11. 48 CFR 3019.705 - Responsibilities for the contracting officer under the subcontracting program.

    Science.gov (United States)

    2010-10-01

    ... contracting officer under the subcontracting program. 3019.705 Section 3019.705 Federal Acquisition...) SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS The Small Business Subcontracting Program 3019.705 Responsibilities for the contracting officer under the subcontracting program. ...

  12. Putative ACP phosphodiesterase gene (acpD) encodes an azoreductase.

    Science.gov (United States)

    Nakanishi, M; Yatome, C; Ishida, N; Kitade, Y

    2001-12-07

    An FMN-dependent NADH-azoreductase of Escherichia coli was purified and analyzed for identification of the gene responsible for azo reduction by microorganisms. The N-terminal sequence of the azoreductase conformed to that of the acpD gene product, acyl carrier protein phosphodiesterase. Overexpression of the acpD gene provided the E. coli with a large amount of the 23-kDa protein and more than 800 times higher azoreductase activity. The purified gene product exhibited activity corresponding to that of the native azoreductase. The reaction followed a ping-pong mechanism requiring 2 mol of NADH to reduce 1 mol of methyl red (4'-dimethylaminoazobenzene-2-carboxylic acid) into 2-aminobenzoic acid and N,N'-dimethyl-p-phenylenediamine. On the other hand, the gene product could not convert holo-acyl carrier protein into the apo form under either in vitro or in vivo conditions. These data indicate that the acpD gene product is not acyl carrier protein phosphodiesterase but an azoreductase.

  13. 48 CFR 319.705 - Responsibilities of the Contracting Officer under the subcontracting assistance program.

    Science.gov (United States)

    2010-10-01

    ... Contracting Officer under the subcontracting assistance program. 319.705 Section 319.705 Federal Acquisition Regulations System HEALTH AND HUMAN SERVICES SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Subcontracting... Responsibilities of the Contracting Officer under the subcontracting assistance program. ...

  14. 48 CFR 219.705 - Responsibilities of the contracting officer under the subcontracting assistance program.

    Science.gov (United States)

    2010-10-01

    ... contracting officer under the subcontracting assistance program. 219.705 Section 219.705 Federal Acquisition... BUSINESS PROGRAMS The Small Business Subcontracting Program 219.705 Responsibilities of the contracting officer under the subcontracting assistance program. ...

  15. 48 CFR 2019.705 - Responsibilities of the contracting officer under the subcontracting assistance program.

    Science.gov (United States)

    2010-10-01

    ... contracting officer under the subcontracting assistance program. 2019.705 Section 2019.705 Federal Acquisition Regulations System NUCLEAR REGULATORY COMMISSION SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Subcontracting... Responsibilities of the contracting officer under the subcontracting assistance program. ...

  16. Cardiovascular Risk Factors and Behavioral Contracting in Exercise Programs.

    Science.gov (United States)

    Neale, Anne Victoria; And Others

    The use of behavioral contracting in exercise programs has been shown to be effective in increasing the frequency of exercise activity and in reducing dropout rates. A study was undertaken to examine the impact of three cardiovascular risk factors (poor physical fitness, obesity, and smoking) on both client willingness to sign a behavioral…

  17. 48 CFR 1419.705 - Responsibilities of the contracting officer under the subcontracting assistance program.

    Science.gov (United States)

    2010-10-01

    ... contracting officer under the subcontracting assistance program. 1419.705 Section 1419.705 Federal Acquisition... Business Subcontracting Program 1419.705 Responsibilities of the contracting officer under the subcontracting assistance program. ...

  18. A Game-Theoretic Model for Distributed Programming by Contract

    DEFF Research Database (Denmark)

    Henriksen, Anders Starcke; Hvitved, Tom; Filinski, Andrzej

    2009-01-01

    We present an extension of the programming-by-contract (PBC) paradigm to a concurrent and distributed environment.  Classical PBC is characterized by absolute conformance of code to its specification, assigning blame in case of failures, and a hierarchical, cooperative decomposition model – none...... of which extend naturally to a distributed environment with multiple administrative peers. We therefore propose a more nuanced contract model based on quantifiable performance of implementations; assuming responsibility for success; and a fundamentally adversarial model of system integration, where each...

  19. Solar buildings program contract summary, calendar year 1999

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-06-07

    The mission of the US Department of Energy's Solar Buildings Program is to advance the development and widespread deployment of competitive solar thermal technologies for use in buildings. The long-term goal of the Program is to combine solar energy technologies with energy-efficient construction techniques and create cost-effective buildings that have a zero net need for fossil fuel energy on an annual basis. The Solar Buildings Program conducts research and development on solar technologies that can deliver heat, light, and hot water to residential and commercial buildings. By working closely with manufacturers in both the buildings and solar energy industries and by supporting research at universities and national laboratories, the Solar Buildings Program brings together the diverse players developing reliable and affordable solar technologies for building applications. The National Renewable Energy Laboratory (NREL) in Golden, Colorado, and Sandia National Laboratories (SNL) in Albuquerque, New Mexico, jointly participate in the Solar Buildings Program. These two national laboratories work closely with industry researching new concepts, developing technology improvements, reducing manufacturing costs, monitoring system performance, promoting quality assurance, and identifying potential new markets. In calendar year 1999, the Solar Buildings Program focused primarily on solar hot water system research and development (R and D), US industry manufacturing assistance, and US market assistance. The Program also completed a number of other projects that were begun in earlier years. This Contract Summary describes the Program's contracted activities that were active during 1999.

  20. Project Hanford Management Contract (PHMC) pollution prevention program implementation plan

    Energy Technology Data Exchange (ETDEWEB)

    Place, B.G., Westinghouse Hanford

    1996-12-31

    This plan documents the Project Hanford Management Contract (PHMC) Pollution Prevention/Waste Minimization (P2/WMin) Program. The subject implementation plan has been updated to reflect the Fiscal Year (FY) 1997 contract structure in which Fluor Daniel Hanford, Inc. (FDH) is the management and integration contractor. The P2/WMin Program scope includes FDH as the principal PHMC contractor, and B&W Hanford Company (BWHC), Duke Engineering & Services Hanford, Inc. (DESH), Lockheed Martin Hanford Corporation, (LMHC), Numatec Hanford Corporation (NHC), Rust Federal Services of Hanford, Inc. (RFSH), and DynCorp Tri-Cities Services, Inc. (DYN) as PHMC contractors, as well as subcontracting enterprise companies, such as Fluor Daniel Northwest, Inc. (FDNW), Lockheed Martin Services, Inc. (LMSI), and Rust Federal Services Northwest (RFS), which provide engineering, operation, construction, maintenance, and computer services for the Hanford Site. The P2/WMin Program scope also includes all other subcontractor-affiliated enterprise companies, such as B&W Protec, Inc. (BWP), DE&S Northwest, Inc. (DESNW), and SGN Eurisys Services Corp. (SESC).

  1. HUYGENS ACP CALIBRATED ENGINEERING & SCIENCE DATA

    Data.gov (United States)

    National Aeronautics and Space Administration — This data set is composed of data produced during the descent to Titan on January 14 2005 from the ACP instrument (Engineering data) and also from the GCMS...

  2. Qualitative evaluation of advanced care planning in early dementia (ACP-ED.

    Directory of Open Access Journals (Sweden)

    Michaela Poppe

    Full Text Available BACKGROUND: End-of-life-care is often poor in individuals with dementia. Advanced care planning (ACP has the potential to improve end-of-life care in dementia. Commonly ACP is completed in the last six months of life but in dementia there may be problems with this as decision-making capacity and ability to communicate necessarily decrease as the disease progresses. Choosing the right time to discuss ACP with people with dementia may be challenging given the duration of the illness may be up to nine years. AIMS: To explore the acceptability of discussing ACP with people with memory problems and mild dementia shortly after diagnosis. METHODS: In-depth interviews were conducted with 12 patients and eight carers who had participated in ACP discussions and six staff members from a memory clinic and a community mental health team who had either conducted or attended the discussions for training purposes. RESULTS: Patients and carers found ACP a positive intervention that helped them think about the future, enabled people with dementia to make their wishes known, and resulted in their feeling relieved and less worried about the future. The importance of sharing the ACP documentation between health service providers was highlighted. CONCLUSIONS: This qualitative evaluation of ACP in early dementia has encouragingly positive results which support the wider application of the intervention in memory services and community mental health teams. Strategies are suggested to support the implementation of ACP further in clinical practice.

  3. A case study of the Advanced Amphibious Assault Vehicle (AAVP) program from a contracting perspective

    OpenAIRE

    Dalton, Ronald R.

    1998-01-01

    This research effort focused on the contracting history of the U.S. Marine Corps Advanced Amphibious Assault Vehicle (AAAV) Program. The research answered the primary question of what were the critical contracting decisions that have been made during the program and how would an analysis of these contracting decisions affect the future of the AAAV program. Interviews were conducted with personnel from the AAAV program office and other Government agencies as well as with contractor employees. ...

  4. 26 CFR 1.401(m)-2 - ACP test.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 5 2010-04-01 2010-04-01 false ACP test. 1.401(m)-2 Section 1.401(m)-2 Internal... TAXES Pension, Profit-Sharing, Stock Bonus Plans, Etc. § 1.401(m)-2 ACP test. (a) Actual contribution percentage (ACP) test—(1) In general—(i) ACP test formula. A plan satisfies the ACP test for a plan year only...

  5. Cost Effectiveness of Iran National Plasma Contract Fractionation Program

    Directory of Open Access Journals (Sweden)

    Abdol Majid Cheraghali

    2012-10-01

    Full Text Available Plasma derived medicines (PDM including immunoglobulins, clotting factors and albumin are life saving medicines which due to their high costs are inaccessible for many patients living in developing countries. By contrary substantial volume of plasma as raw materials for production of these medicines are discarded worldwide. Good quality recovered plasma, as a result of separation of donated blood into its components, could be used for production of PDM. In 2011 Iranian donors donated about 2 million units of blood. A shift fromadministration of whole blood to components therapy has resulted in the generation of over 250,000 liters of surplus of recovered plasma. This created a good opportunity for Iran’s health care system to use this plasma for production of PDM. Therefore Iran national transfusion service has started a contract fractionation program for converting recovered plasma into PDM. This program not only provided essential PDM for Iran pharmaceutical market but also has created a direct saving of about 8.5 million Euros in 2011 for national health sector. In addition this program has drastically contributed to improvement of overall quality of working procedures and services provided by Iran national blood transfusion organization.

  6. Accelerating the Contracting Process--A Case Study of the Small ICBM program

    Science.gov (United States)

    1985-04-01

    1 -- Small Missile Program Office Organization - 11 FIGURE 2-2 -- SICBM Program Contract Activities Summary- 13 vi EXECUTIVE SUMMARY A Part of our...continue to look deeper into the program office organization , management, and contracting methodology used on the Small ICBM Program in hopes of finding...program office resulted in prevention of a major delay in the acquisition schedule. Management’s approach to program office organization clearly held

  7. A Study of Customized Contract Training Programs at Selected Community Colleges.

    Science.gov (United States)

    Warford, Larry J.

    In 1987, a study was conducted to assess the status of customized contract training programs in 16 League for Innovation community college districts and to examine the issues surrounding the establishment of these programs. An initial survey requested information on the current status of contract training programs. A subsequent survey, employing…

  8. 75 FR 10272 - Notice Regarding 340B Drug Pricing Program-Contract Pharmacy Services

    Science.gov (United States)

    2010-03-05

    ... Administration Notice Regarding 340B Drug Pricing Program--Contract Pharmacy Services AGENCY: Health Resources... parties of final guidelines regarding the utilization of multiple contract pharmacies and suggested contract pharmacy provisions, which had been previously limited to the Alternative Methods Demonstration...

  9. 48 CFR 227.7104 - Contracts under the Small Business Innovation Research (SBIR) Program.

    Science.gov (United States)

    2010-10-01

    ... PATENTS, DATA, AND COPYRIGHTS Rights in Technical Data 227.7104 Contracts under the Small Business... Data and Computer Software—Small Business Innovation Research (SBIR) Program, when technical data or computer software will be generated during performance of contracts under the SBIR program. (b) Under the...

  10. 48 CFR 19.705 - Responsibilities of the contracting officer under the subcontracting assistance program.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Responsibilities of the contracting officer under the subcontracting assistance program. 19.705 Section 19.705 Federal Acquisition... Business Subcontracting Program 19.705 Responsibilities of the contracting officer under the subcontracting...

  11. 48 CFR 1319.705 - Responsibilities of the contracting officer under the subcontracting assistance program.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Responsibilities of the contracting officer under the subcontracting assistance program. 1319.705 Section 1319.705 Federal Acquisition... Subcontracting Program 1319.705 Responsibilities of the contracting officer under the subcontracting assistance...

  12. 48 CFR 619.705 - Responsibilities of the contracting officer under the subcontracting assistance program.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Responsibilities of the contracting officer under the subcontracting assistance program. 619.705 Section 619.705 Federal Acquisition... Subcontracting Program 619.705 Responsibilities of the contracting officer under the subcontracting assistance...

  13. 14 CFR 91.1003 - Management contract between owner and program manager.

    Science.gov (United States)

    2010-01-01

    ... RULES Fractional Ownership Operations § 91.1003 Management contract between owner and program manager... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Management contract between owner and program manager. 91.1003 Section 91.1003 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT...

  14. 48 CFR 3419.705 - Responsibilities of the contracting officer under the subcontracting assistance program.

    Science.gov (United States)

    2010-10-01

    ... contracting officer under the subcontracting assistance program. 3419.705 Section 3419.705 Federal Acquisition... SMALL DISADVANTAGED BUSINESS CONCERNS Subcontracting With Small Business and Small Disadvantaged Business Concerns 3419.705 Responsibilities of the contracting officer under the subcontracting assistance...

  15. Evaluating Value Chain Development Programs: Assessing Effectiveness, Efficiency, and Equity Effects of Contract Choice

    NARCIS (Netherlands)

    Ruben, R.

    2015-01-01

    Provides insights regarding the possible procedures for assessing welfare, efficiency, and equity effects of value chain development (VCD) programs, taking advantage of available analytical tools derived from impact analysis, transaction cost theory, and contract choice approaches and briefly

  16. The influence of contract type in program execution/V-22 Osprey: A case study

    Science.gov (United States)

    Smith, Danny Roy

    1989-12-01

    The purpose of this study was to look at the impact of a fixed price type contract on program execution of a major weapon system. The full scale development phase of the V-22 Osprey program was used as a case study. The focus of this thesis was to determine the affects of this contract type and identify the actions program management took to address it's influences. The predominant conclusion brought out by this research was that based on the political, historical, and economic circumstances of the period, the fixed price incentive fee contract was the best contractual instrument for the government to use. The major recommendations are: in future contracts, ensure an appropriate spread between ceiling and target price in order to adequately incentivize the contractor; in teaming arrangements, employ incentives to guarantee the appropriate transfer of technical information; and incentivize comprehensive production plans and Production Readiness Reviews.

  17. Contracts and management services site support program plan WBS 6.10.14

    Energy Technology Data Exchange (ETDEWEB)

    Knoll, J.M. Jr.

    1994-09-01

    Contracts and Management Services is recognized as the central focal point for programs having company or sitewide application in pursuit of the Hanford Missions`s financial and operational objectives. Contracts and Management Services actively pursues cost savings and operational efficiencies through: Management Standards by ensuring all employees have an accessible, integrated system of clear, complete, accurate, timely, and useful management control policies and procedures; Contract Reform by restructuring the contract, organization, and cost accounting systems to refocus Hanford contract activities on output products; Systems and Operations Evaluation by directing the Cost Reduction program, Great Ideas, and Span of Management activities; Program Administration by enforcing conditions of Accountability (whether DEAR-based or FAR-based) for WHC, BCSR, ICF KH, and BHI; Contract Performance activities; chairing the WHC Cost Reduction Review Board; and analyzing companywide Performance Measures; Data Standards and Administration by establishing and directing the company data management program; giving direction to the major RL programs and mission areas for implementation of cost-effective and efficient data management practices; directing all operations, application, and interfaces contained within the Hanford PeopleCore System; directing accomplishment and delivery of TPA data management milestones; and directing the sitewide data management processes for Data Standards and the Data Directory.

  18. 78 FR 4478 - Federal Employees Dental and Vision Insurance Program: Application Process for Contract Awards

    Science.gov (United States)

    2013-01-22

    ... MANAGEMENT Federal Employees Dental and Vision Insurance Program: Application Process for Contract Awards AGENCY: U.S. Office of Personnel Management. ACTION: Notice of Application Process for Federal Employees... the Federal Employees Dental and Vision Insurance Program (FEDVIP). This process is being changed to...

  19. Should Your College Start a Center for the Delivery of Contract Training Programs? ERIC Digest.

    Science.gov (United States)

    Deegan, William L.

    Community colleges have been at the forefront in providing contract training programs for clients such as businesses, health care organizations, and government agencies. Many state governments are beginning to provide resources for these programs as an incentive to attract or retain business and industry. One of the consequences of the demand for…

  20. An application of the Autoregressive Conditional Poisson (ACP) model

    CSIR Research Space (South Africa)

    Holloway, Jennifer P

    2010-11-01

    Full Text Available www.csir.co.za Results: ACP & DACP vs Poisson ? Cholera cases modelled using ? Seasonal variables and lag 6 air temperature Parameters ACP DACP Poisson 0.0438 0.0530 0.0214 0.0247 0.2291 0.2628 0.0951 Intercept -0.8624 Lag6 temp 0.1368 0...

  1. 77 FR 1857 - Women-Owned Small Business Federal Contract Program

    Science.gov (United States)

    2012-01-12

    ..., 125, 126, and 127 RIN 3245-AG34 Women-Owned Small Business Federal Contract Program AGENCY: U.S. Small... are already codified in the Federal Acquisition Regulation (FAR) as they relate to the Women-Owned... competition to eligible Women-Owned Small Businesses (WOSBs) or Economically Disadvantaged Women-Owned Small...

  2. Treatment of white spot lesions with ACP paste and microabrasion.

    Science.gov (United States)

    Pliska, Benjamin T; Warner, Gary A; Tantbirojn, Daranee; Larson, Brent E

    2012-09-01

    To examine the effects of application of casein phosphopeptide amorphous calcium phosphate (CPP-ACP) paste and microabrasion treatment on the regression of white spot lesions (WSLs). Artificially-induced WSLs in bovine enamel were randomly assigned to one of four treatment groups: CPP-ACP paste only, microabrasion only, microabrasion and CPP-ACP, and a control. Samples were treated with each regimen twice daily for 2 weeks and stored in remineralizing solution between the treatments. Quantitative light-induced fluorescence was used to measure changes in fluorescence, which indicate changes in mineral content of WSLs immediately before (T1) and 2 weeks after treatment (T2). A two-within-subject factor analysis of variance was used to analyze the significance of any changes in mineral content of the lesions from T1 to T2. There was a statistically significant (P microabrasion only, as well as the microabrasion and CPP-ACP treatments. The changes in fluorescence for the CPP-ACP treatment alone were not statistically significant (P  =  .40). CPP-ACP paste alone does not significantly improve the fluorescence value (ie, the mineral content) of WSLs. Within the limitations of this in vitro study, microabrasion treatment with or without CPP-ACP improved the fluorescence and thus reduced WSLs.

  3. The Navy Supply Corps Newsletter. Contracting Innovations: Navy Electronic Commerce Online Navy Afloat Purchase Card Program. Volume 62, No. 3.

    Science.gov (United States)

    1998-06-01

    tf • lovy Electronic Commerce Online m Afloat Purchase Card Program4 % y5.ll ’ ’"’#K5&. ifekj 1IÜN AB iräri.1 . ■■-■ 11...Contracting Innovations NAVSUP Electronic Commerce in Contracting for Beginners 8 The Afloat Purchase Card Program: Decentralizing Purchasing for...there. J- May/June NAVSUP Electronic Commerce in Contracting for Beginners By Matt Nielsen, NECO Project Manager, Naval Supply Systems Command M he

  4. 25 CFR 170.607 - Can a tribe use its allocation of IRR Program funds for contract support costs?

    Science.gov (United States)

    2010-04-01

    ... costs? Yes. Contract support costs are an eligible item out of a tribe's IRR Program allocation and need... 25 Indians 1 2010-04-01 2010-04-01 false Can a tribe use its allocation of IRR Program funds for contract support costs? 170.607 Section 170.607 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE...

  5. Genetic and bibliographic information: Acp1 [GenLibi

    Lifescience Database Archive (English)

    Full Text Available Acp1 acid phosphatase 1, soluble rat Myoclonic Epilepsy, Juvenile (MeSH) Nervous System... Diseases (C10) > Central Nervous System Diseases (C10.228) > Brain Diseases (C10.228.140) > Epilepsy (C

  6. Contracts and Management Services FY 1996 Site Support Program Plan: WBS 6.10.14. Revision 1

    Energy Technology Data Exchange (ETDEWEB)

    Knoll, J.M. Jr.

    1995-09-01

    This is the Contracts and Management Services site support program plan for the US DOE Hanford site. The topics addressed in the program plan include a mission statement, program objectives, planning assumptions, program constraints, work breakdown structure, milestone list, milestone description sheets, and activity detail including cost accounting narrative summary, approved funding budget, and activity detailed description.

  7. Contract case managers prove cost effective in federal workers' compensation programs.

    Science.gov (United States)

    Mallon, Timothy Michael; Cloeren, Marianne; Firestone, Lisa Michelle; Burch, Helen Christine

    2008-03-01

    This pilot study examined whether contract case managers are cost effective in reducing workers' compensation (WC) costs and preventing injuries. We placed contract medical case managers at four installations where they employed private industry best practices. A needs assessment was performed and site-specific targeted interventions were developed. Case managers improved WC program effectiveness by ensuring command support, and strengthening the case management process. They minimized lost work time and provided the WC team resources to review the oldest cases. Case managers cost $1.25 million and they generated $4.4 million in savings for a 3.52 return on investment. Case managers removed 73 workers from long-term rolls by making use of vocational rehabilitation, finding modified duty jobs, offering workers medical retirement, and terminating benefits when workers refused to work after being offered a job. This study of medical case managers demonstrates they can reduce WC costs.

  8. Mode of action of anticancer peptides (ACPs) from amphibian origin.

    Science.gov (United States)

    Oelkrug, Christopher; Hartke, Martin; Schubert, Andreas

    2015-02-01

    Although cancer belongs to one of the leading causes of death around the world, fortunately studies have shown that tumor cells have various targets that are susceptible to attack. Interestingly, tumor cells are comprised of cellular membranes, which are altered in chemical composition relative to non-neoplastic cells, giving them an increased net negative charge. These altered membranes are ideal targets for antimicrobial peptides (AMPs) shown to have additional tumoricidal properties and, hence, named anticancer peptides (ACPs). Several hundred ACPs have been explored in vitro and in vivo on various types of cancer. Novel anticancer agents are supposed not to cause serious side effects and the formation of multidrug-resistant tumor cells. During the quest for potent ACPs, promising candidates were isolated from skin secretions of amphibians, such as the granular glands of the Chinese brown frog, Rana chensinensis. ACPs have to be selective to cancer cells and should not induce strong immune responses or be cleared from the body rapidly. Several modifications can improve ACPs either by optimizing the primary structure rationally or randomly or even by introducing other chemical modifications. Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

  9. Design Report for ACP Hot Cell Rear Door

    Energy Technology Data Exchange (ETDEWEB)

    Ku, J. H.; Kwon, K. C.; Choung, W. M.; Cho, I. J.; Kook, D. H.; Lee, W. K.; You, G. S.; Lee, E. P.; Park, S. W

    2005-12-15

    A hot-cell facility was constructed at the IMEF building for the demonstrate ACP process. ACP hot-cell consists of process cell and maintenance cell, and each cell has rear door. Since this facility was constructed at basement floor, all process materials, equipment and radioactive materials are take in and out through the rear door. Also, this door can be an access route of workers for the maintenance works. Therefore ACP hot-cell rear doors must maintain the radiation shielding, sealing, mechanical and structural safety. This report presents design criteria, design contents of each part and driving part. It was confirmed that the rear doors sufficiently maintain the safety through the structural analysis and shielding analysis. Also, it was confirmed that the rear doors were constructed as designed by the gamma scanning test after the installation.

  10. 48 CFR 227.7204 - Contracts under the Small Business Innovative Research Program.

    Science.gov (United States)

    2010-10-01

    ... DEFENSE ACQUISITION REGULATIONS SYSTEM, DEPARTMENT OF DEFENSE GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Rights in Computer Software and Computer Software Documentation 227.7204 Contracts...

  11. Molecular cloning and characterization of an acyl-ACP thioesterase ...

    African Journals Online (AJOL)

    Acyl-acyl carrier protein (ACP) thioesterase is a nuclear encoded plastid localized enzyme which plays an essential role in chain termination during de novo fatty acid synthesis in plant. FatB genes coding for this enzyme from a variety of plant species have been isolated and characterized. However, there are few reports on ...

  12. Economic Partnership between the ACP countries and the EU

    NARCIS (Netherlands)

    Van Hoestenberghe, K.; Roelfsema, H.J.

    2006-01-01

    In this paper we explore the nature and effects of the Economic Partnership Agreements (EPAs) between the EU and groups of African, Caribbean and Pacific (ACP) countries. We argue that the direct economic effects from reciprocal trade liberalization - both positive and negative – may be rather

  13. Economic Partnership Agreements and Regional Integration among ACP Countries

    NARCIS (Netherlands)

    Faber, G.

    2001-01-01

    New initiatives are needed to increase the effectiveness of the trade policy instruments the EU uses in its policy of development cooperation with the ACP countries. Merely giving non-reciprocal preferences has not worked very well. The main reason for this failure is that non-reciprocal preferences

  14. Molecular cloning and characterization of an acyl-ACP thioesterase ...

    African Journals Online (AJOL)

    ajl11

    , 280(5):3621-3627. Moreno-Pérez AJ, Sánchez-García A, Salas JJ, Garcés R, Martínez-. Force E (2011). Acyl-ACP thioesterases from macadamia. (Macadamia tetraphylla) nuts: Cloning, characterization and their impact on oil composition.

  15. U.S. Department of Energy Photovoltaic Energy Program Contract Summary: Fiscal Year 2000

    Energy Technology Data Exchange (ETDEWEB)

    Surek, T.

    2001-02-21

    This report summarizes the in-house and subcontracted research and development (R and D) activities under the National Center for Photovoltaics (NCPV) and U.S. Department of Energy (DOE) National Photovoltaics Program from October 1, 1999, through September 30, 2000 (FY 2000). The mission of the DOE National Photovoltaics Program is to make PV a significant part of the domestic economy-as an industry and an energy resource. The two primary goals of the national program are to (1) maintain the U.S. industry's world leadership in research and technology development and (2) help the U.S. industry remain a major, profitable force in the world market. The NCPV is part of the National PV Program and provides leadership and support to the national program toward achieving its mission and goals. This Contract Summary for fiscal year (FY) 2000 documents some 179 research projects supported by the PV Program, performed by 107 organizations in 32 states, including 69 projects performed by universities and 60 projects performed by our industry partners. Of the total FY 2000 PV Program budget of $65.9 million, the industry and university research efforts received $36.9 million, or nearly 56%. And, of this amount, more than 93% was for contractors selected on a competitive basis. Much of the funding to industry was matched by industry cost-sharing. Each individual effort described in this summary represents another step toward improving PV manufacturing, performance, cost, and applications, and another step toward accomplishing the DOE PV Program's overall mission.

  16. Simultaneous Detection of ACP1 and GC Genotypes Using PCR/SSCP

    DEFF Research Database (Denmark)

    Dissing, Jørgen; Thymann, Mariann; Hopkinson, David

    2003-01-01

    ACP1, GC, acid phosphatase, phosphotyrosine phosphatase, group specific component, SSCP, alleles, classical genetic markers......ACP1, GC, acid phosphatase, phosphotyrosine phosphatase, group specific component, SSCP, alleles, classical genetic markers...

  17. Fossil Energy Program report, 1 October 1976--30 September 1977. [Objectives, progress and plans for each contract or project

    Energy Technology Data Exchange (ETDEWEB)

    Dunning, H. Neal; Batchelor, James; Crim, Winfred; Furlong, Leroy; Harvie, Robert; Hunter, Juanita; Jones, William; Karnes, Anita; Ludwig, Linda; Miller, C. Lowell; Mills, G. Alex; Sacks, Stephen; Watkins, J. Wade; Watson, Coni; Weaver, Val

    1978-08-01

    This report is an integral part of the documentation system of the Fossil Energy Program of the Department of Energy. It contains descriptions of each contract and project, arranged in conformance with planning and budgetary documents. The results of contracts are reported at various intervals, depending on the type of contract, but at least annually. These reports are not listed individually in the ''Publications'' sections but are available from the National Technical Information Service, U.S. Department of Commerce, Springfield, Virginia 22161. The Department of Energy also publishes several abstract journals: Fossil Energy Update, Energy Research Abstracts, and Energy Abstracts for Policy Analysis.

  18. Modeling holo-ACP:DH and holo-ACP:KR complexes of modular polyketide synthases: a docking and molecular dynamics study

    Directory of Open Access Journals (Sweden)

    Anand Swadha

    2012-05-01

    Full Text Available Abstract Background Modular polyketide synthases are multifunctional megasynthases which biosynthesize a variety of secondary metabolites using various combinations of dehydratase (DH, ketoreductase (KR and enoyl-reductase (ER domains. During the catalysis of various reductive steps these domains act on a substrate moiety which is covalently attached to the phosphopantetheine (P-pant group of the holo-Acyl Carrier Protein (holo-ACP domain, thus necessitating the formation of holo-ACP:DH and holo-ACP:KR complexes. Even though three dimensional structures are available for DH, KR and ACP domains, no structures are available for DH or KR domains in complex with ACP or substrate moieties. Since Ser of holo-ACP is covalently attached to a large phosphopantetheine group, obtaining complexes involving holo-ACP by standard protein-protein docking has been a difficult task. Results We have modeled the holo-ACP:DH and holo-ACP:KR complexes for identifying specific residues on DH and KR domains which are involved in interaction with ACP, phosphopantetheine and substrate moiety. A novel combination of protein-protein and protein-ligand docking has been used to first model complexes involving apo-ACP and then dock the phosphopantetheine and substrate moieties using covalent connectivity between ACP, phosphopantetheine and substrate moiety as constraints. The holo-ACP:DH and holo-ACP:KR complexes obtained from docking have been further refined by restraint free explicit solvent MD simulations to incorporate effects of ligand and receptor flexibilities. The results from 50 ns MD simulations reveal that substrate enters into a deep tunnel in DH domain while in case of KR domain the substrate binds a shallow surface exposed cavity. Interestingly, in case of DH domain the predicted binding site overlapped with the binding site in the inhibitor bound crystal structure of FabZ, the DH domain from E.Coli FAS. In case of KR domain, the substrate binding site

  19. Cross-scale Efficient Tensor Contractions for Coupled Cluster Computations Through Multiple Programming Model Backends

    Energy Technology Data Exchange (ETDEWEB)

    Ibrahim, Khaled Z. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Computational Research Division; Epifanovsky, Evgeny [Q-Chem, Inc., Pleasanton, CA (United States); Williams, Samuel W. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Computational Research Division; Krylov, Anna I. [Univ. of Southern California, Los Angeles, CA (United States). Dept. of Chemistry

    2016-07-26

    Coupled-cluster methods provide highly accurate models of molecular structure by explicit numerical calculation of tensors representing the correlation between electrons. These calculations are dominated by a sequence of tensor contractions, motivating the development of numerical libraries for such operations. While based on matrix-matrix multiplication, these libraries are specialized to exploit symmetries in the molecular structure and in electronic interactions, and thus reduce the size of the tensor representation and the complexity of contractions. The resulting algorithms are irregular and their parallelization has been previously achieved via the use of dynamic scheduling or specialized data decompositions. We introduce our efforts to extend the Libtensor framework to work in the distributed memory environment in a scalable and energy efficient manner. We achieve up to 240 speedup compared with the best optimized shared memory implementation. We attain scalability to hundreds of thousands of compute cores on three distributed-memory architectures, (Cray XC30&XC40, BlueGene/Q), and on a heterogeneous GPU-CPU system (Cray XK7). As the bottlenecks shift from being compute-bound DGEMM's to communication-bound collectives as the size of the molecular system scales, we adopt two radically different parallelization approaches for handling load-imbalance. Nevertheless, we preserve a uni ed interface to both programming models to maintain the productivity of computational quantum chemists.

  20. Automated evaluation of matrix elements between contracted wavefunctions: A Mathematica version of the FRODO program

    Science.gov (United States)

    Angeli, C.; Cimiraglia, R.

    2013-02-01

    A symbolic program performing the Formal Reduction of Density Operators (FRODO), formerly developed in the MuPAD computer algebra system with the purpose of evaluating the matrix elements of the electronic Hamiltonian between internally contracted functions in a complete active space (CAS) scheme, has been rewritten in Mathematica. New version : A program summaryProgram title: FRODO Catalogue identifier: ADV Y _v2_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/ADVY_v2_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.: 3878 No. of bytes in distributed program, including test data, etc.: 170729 Distribution format: tar.gz Programming language: Mathematica Computer: Any computer on which the Mathematica computer algebra system can be installed Operating system: Linux Classification: 5 Catalogue identifier of previous version: ADV Y _v1_0 Journal reference of previous version: Comput. Phys. Comm. 171(2005)63 Does the new version supersede the previous version?: No Nature of problem. In order to improve on the CAS-SCF wavefunction one can resort to multireference perturbation theory or configuration interaction based on internally contracted functions (ICFs) which are obtained by application of the excitation operators to the reference CAS-SCF wavefunction. The previous formulation of such matrix elements in the MuPAD computer algebra system, has been rewritten using Mathematica. Solution method: The method adopted consists in successively eliminating all occurrences of inactive orbital indices (core and virtual) from the products of excitation operators which appear in the definition of the ICFs and in the electronic Hamiltonian expressed in the second quantization formalism. Reasons for new version: Some years ago we published in this journal a couple of papers [1, 2

  1. 7 CFR 1430.212 - Contract modifications and statutory changes in program.

    Science.gov (United States)

    2010-01-01

    ... the next fiscal year, death of producer on the contract, new member joining the operation, member... contract preceded the statutory change. Operations will be given the option of accepting the changes or...

  2. Lowest Price, Technically Acceptable Evaluation Criteria Used in the November 2014 Request for Proposal for the Program Executive Office Soldier Systems Engineering and Technical Assistance (SETA) Contract

    Science.gov (United States)

    2017-09-01

    USED IN THE NOVEMBER 2014 REQUEST FOR PROPOSAL FOR THE PROGRAM EXECUTIVE OFFICE SOLDIER SYSTEMS ENGINEERING AND TECHNICAL ASSISTANCE (SETA) CONTRACT...NOVEMBER 2014 REQUEST FOR PROPOSAL FOR THE PROGRAM EXECUTIVE OFFICE SOLDIER SYSTEMS ENGINEERING AND TECHNICAL ASSISTANCE (SETA) CONTRACT 5. FUNDING...evaluation process for replies received in response to a request for proposal (RFP) for systems engineering and technical assistance (SETA) support

  3. 75 FR 6685 - Section 8 Housing Assistance Payments Program-Contract Rent Annual Adjustment Factors, Fiscal...

    Science.gov (United States)

    2010-02-10

    ... Expenditure Survey (CEX) and American Community Survey (ACS) data on the ratio of utilities to rents.\\2\\ \\1....HUDUSER.org Survey Data Used to Produce Contract Rent AAFs In this publication, the rent and fuel and... AAFs. The utility- to-rent ratio used to produce Contract Rent AAFs comes from 2007 ACS median rent and...

  4. 76 FR 14421 - Section 8 Housing Assistance Payments Program-Contract Rent Annual Adjustment Factors (AAFs...

    Science.gov (United States)

    2011-03-16

    ... Survey (ACS) data on the ratio of utilities to rents.\\2\\ \\1\\ CPI indexes CUUSA103SEHA and CUSR0000SAH2... AAFs In this publication, the rent and fuel and utilities inflation factors for large metropolitan... produce Contract Rent AAFs comes from 2008 ACS median rent and utility costs. Geographic Areas Contract...

  5. Army Contract Writing System (ACWS)

    Science.gov (United States)

    2016-03-01

    2016 Major Automated Information System Annual Report Army Contract Writing System (ACWS) Defense Acquisition Management Information Retrieval...Program Information Program Name Army Contract Writing System (ACWS) DoD Component Army Responsible Office Program Manager References MAIS...UNCLASSIFIED 4 Program Description The Army Contract Writing System (ACWS) will be the Army’s single, next-generation, enterprise-wide contract writing

  6. In situ effect of CPP-ACP chewing gum upon erosive enamel loss

    OpenAIRE

    de ALENCAR, Catarina Ribeiro Barros; de OLIVEIRA, Gabriela Cristina; MAGALH?ES, Ana Carolina; BUZALAF, Mar?lia Afonso Rabelo; MACHADO, Maria Aparecida de Andrade Moreira; HON?RIO, Heitor Marques; RIOS, Daniela

    2017-01-01

    Abstract Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) is able to increase salivary calcium and phosphate levels at an acidic pH. Previous studies demonstrated that a CPP-ACP chewing gum was able to enhance the re-hardening of erosion lesions, but could not diminish enamel hardness loss. Therefore, there is no consensus regarding the effectiveness of CPP-ACP on dental erosion. Objective This in situ study investigated the ability of a CPP-ACP chewing gum in preventing erosive e...

  7. Structure of the Neisseria Adhesin Complex Protein (ACP) and its role as a novel lysozyme inhibitor

    Science.gov (United States)

    Lian, Lu-Yun

    2017-01-01

    Pathogenic and commensal Neisseria species produce an Adhesin Complex Protein, which was first characterised in Neisseria meningitidis (Nm) as a novel surface-exposed adhesin with vaccine potential. In the current study, the crystal structure of a recombinant (r)Nm-ACP Type I protein was determined to 1.4 Å resolution: the fold resembles an eight-stranded β-barrel, stabilized by a disulphide bond between the first (Cys38) and last (Cys121) β-strands. There are few main-chain hydrogen bonds linking β4-β5 and β8-β1, so the structure divides into two four-stranded anti-parallel β-sheets (β1-β4 and β5-β8). The computed surface electrostatic charge distribution showed that the β1-β4 sheet face is predominantly basic, whereas the β5-β8 sheet is apolar, apart from the loop between β4 and β5. Concentrations of rNm-ACP and rNeisseria gonorrhoeae-ACP proteins ≥0.25 μg/ml significantly inhibited by ~80–100% (PNeisseria ACP sera to block ACP inhibition and restore HL activity. ACP expression conferred tolerance to HL activity, as demonstrated by significant 3–9 fold reductions (PNeisseria lactamica treated with purified ACP-specific rabbit IgG antibodies showed similar fold reductions in bacterial growth, compared with untreated bacteria (PNeisseria ACP proteins show Neisseria ACP adopts a different mode of lysozyme inhibition and that the ability of ACP to inhibit lysozyme activity could be important for host colonization by both pathogenic and commensal Neisseria organisms. Thus, ACP represents a dual target for developing Neisseria vaccines and drugs to inhibit host-pathogen interactions. PMID:28662181

  8. LHCb : Measuring $CP$ violation with $\\Delta A_{CP}$ at LHCb

    CERN Multimedia

    Pearce, A

    2014-01-01

    Measurements are presented of direct $CP$ violation in $D^{0}$ meson decays in LHCb, using the $\\Delta A_{CP}$ technique, and a proposal is outlined to make similar measurements in the decays of the charmed baryon $\\Lambda_{c}^{+}$. The motivations for use of the $\\Delta A_{CP}$ method are discussed, along with the current results and future prospects.

  9. Preference Utilisation and Tariff Reduction in EU Imports from ACP Countries

    NARCIS (Netherlands)

    M. Manchin (Miriam)

    2004-01-01

    textabstractDespite the long relationship between the EU and the African, Caribbean and Pacific (ACP) countries aimed at encouraging their exports while stimulating growth and investment, the ACP states still face difficulties in integrating into the world economy. This paper examines the non-least

  10. 75 FR 10029 - Women-Owned Small Business Federal Contract Program

    Science.gov (United States)

    2010-03-04

    ..., and therefore its reluctance to register on the CCR could itself result from gender discrimination... 127 that include eliminating the requirement for an agency-by-agency determination of discrimination... discrimination that have inhibited the ability of women to form firms and then to compete equally for contracts...

  11. 76 FR 76811 - Stakeholders Meeting Regarding Ready Reserve Force (RRF) Ship Manager Contract Program

    Science.gov (United States)

    2011-12-08

    ..., Ship Costs, Green Initiatives. Limited Scope Ship Management Contract for State Maritime Academy Schoolships. The meeting is open to the public. Due to space constraints, participation is limited to two (2) representatives per company/ organization. Advanced registration is recommended. The DOT building at 1200 New...

  12. 7 CFR 1726.304 - List of electric program standard contract forms.

    Science.gov (United States)

    2010-01-01

    .... 1726.304 Section 1726.304 Agriculture Regulations of the Department of Agriculture (Continued) RURAL... 198, Rev. 4-04, Equipment Contract. This form is used for equipment purchases. (5) RUS Form 200, Rev... the furnishing and installation of major items of equipment. (6) RUS Form 213, Rev. 2-04, Certificate...

  13. 25 CFR Appendix A to Subpart E - IRR Program Functions That Are Not Otherwise Contractible

    Science.gov (United States)

    2010-04-01

    ... State/tribal/Federal permits are obtained; 3. Performing quality assurance activities; 4. Conducting...-project-related management activities. I. BIADOT program management: 1. Developing budget on needs for the... Assistance Program, Recreational Travel and Tourism, Transit Program, ERFO Program, Presidential initiatives...

  14. [The role of the Constitutional Court on the analysis of contracts of prepaid medicine programs].

    Science.gov (United States)

    Quintana-Cepeda, Anamaría

    2016-01-01

    Since 1991, when the current Colombian Constitution came into force and the Constitutional Court was appointed as its guardian and protector, constitutional values have permeated all subjects and areas of law, even those that were previously considered as private matters. Prepaid medicine contracts are a good example of this phenomenon, since the Colombian Constitutional Court has limited individual freedom of contract to private parties -prepaid medical companies- for the benefit of final users of this service through "acción de tutela", in order to protect the right to healthcare and to prevent some behaviors that violate the principle of good faith. The Court has demanded private companies to assess the health condition of patients and has prohibited pre-existent and exclusion clauses that diminish the responsibilities of said companies. Nevertheless, there is a gap in the law regarding the duties of good faith that concern the user, which will be addressed in this paper.

  15. Annual Growth of Contract Costs for Major Programs in Development and Early Production

    Science.gov (United States)

    2016-03-21

    particular year). This correction function serves as a kind of negative feedback that keeps costs under control. Figure 1: Actual Growth of Contract...above, none of this work relates to government costs or firm- fixed-price costs, which are the majority of production efforts. The two significant... Under Secretary of Defense for Acquisition, Technology, and Logistics (AT&L), Performance of the Defense Acquisition System, 2015 Annual Report, U.S

  16. Effectiveness of adding voluntary pelvic floor muscle contraction to a Pilates exercise program: an assessor-masked randomized controlled trial.

    Science.gov (United States)

    Torelli, Luiza; de Jarmy Di Bella, Zsuzsanna Ilona Katalin; Rodrigues, Claudinei Alves; Stüpp, Liliana; Girão, Manoel João Batista Castello; Sartori, Marair Gracio Ferreira

    2016-11-01

    The purpose of this study was to evaluate the effectiveness of adding voluntary pelvic floor muscle contraction (PFMC) to a Pilates exercise program in sedentary nulliparous women. Fifty-seven healthy nulliparous and physically inactive women were randomized to a Pilates exercise program (PEP) with or without PFMC. Forty-eight women concluded this study (24 participants for each group). Each woman was evaluated before and after the PEP, by a physiotherapist and an urogynecologist (UG). Neither of the professionals was revealed to them. This physiotherapist measured their pelvic floor muscle strength by using both a perineometer (Peritron) and vaginal palpation (Oxford Scale). The UG, who performed 3D perineal ultrasound examinations, collected their data and evaluated the results for pubovisceral muscle thickness and the levator hiatus area (LA). Both professionals were blinded to the group allocation. The protocol for both groups consisted of 24 bi-weekly 1-h individual sessions of Pilates exercises, developed by another physiotherapist who specializes in PFM rehabilitation and the Pilates technique. The PEP+ PFMC group showed significantly greater strength improvements than the PEP group when comparing the Oxford scale, vaginal pressure and pubovisceral muscle thickness during contraction measurements at baseline and post-treatment. Our findings suggest that adding a voluntary PFMC to a Pilates exercise program is more effective than Pilates alone in improving PFM strength in sedentary nulliparous women.

  17. CPP-ACP: Effect on Dental Plaque Acidity after Water Rinsing Following Topical Fluoride Therapy.

    Science.gov (United States)

    Fatemeh, Mazhari; Marjan, Sharifi; Homa, Noorollahian; Mahsa, Sharifi

    There is some evidence that water rinsing immediately after topical fluoride therapy has the potential to reduce the effectiveness of fluoride. The aim was to determine if covering fluoridated teeth with a layer of mousse containing CPP-ACP could prevent the adverse effect of rinsing on fluoride and consequently its buffering effect on dental plaque pH during cariogenic challenge. This randomized, controlled, crossover, in situ study was conducted on 25 participants. The participants were subjected to acidulated phosphate fluoride (APF) application followed by five treatment protocols: (1) water rinsing after 30 minutes (APF-30) or (2) immediate water rinsing (APF-0); (3) using CPP-ACP immediately before water rinsing (F-CPP-ACP); and two control groups: (4) no fluoride therapy (No-F) and (5) using CPP-ACP and immediate water rinsing (CPP-ACP-0). After 48 hours, teeth were rinsed with 10% sucrose solution and plaque pH was measured before and after 5, 10, 15, 20 and 30 minutes. The least pH changes, the lowest pH drop, and the quickest pH recovery were found in the APF-30 and F-CPP-ACP groups. APF-0 ranked in the middle and the highest values were in the control groups. The results show that in the case using CPP-ACP on fluoridated teeth, water rinsing immediately after topical fluoride therapy did not seem to influence the inhibitory effect of fluoride on plaque acidity.

  18. Acyl carrier protein (ACP) inhibition and other differences between b-ketoacyl synthase (KAS) I and II

    DEFF Research Database (Denmark)

    McGuire, Kirsten Arnvig; McGuire, J.N.; Wettstein-Knowles, Penny von

    2000-01-01

    , whereas KAS I also forms higher multimers. The binding affinities for KAS I and KAS II to C14-acyl carrier protein (ACP) as well as for C14-ACP to KAS I and KAS II were determined. KAS I is sensitive to the ACP released during the transfer reaction, with 50% inhibition at 0.17 µM ACP close...... to the physiological concentration of ACP (0.13 µM). KAS I and II also differ in carrying out the decarboxylation step of the elongation reaction....

  19. Design Report for Hotcell Crane of ACP Facility

    Energy Technology Data Exchange (ETDEWEB)

    Ku, J. H.; You, G. S.; Choung, W. M.; Kwon, K. C.; Cho, I. J.; Kook, D. H.; Lee, W. K.; Lee, E. P.; Park, S. W

    2005-12-15

    For the handling of the process material, equipment, and radioactive material transport cask, hot-cell crane, crane gate and jib crane are designed and constructed in the advanced spent fuel conditioning process (ACP) demonstration facility. The in-cell crane and the crane gate were installed in the hot-cell, and the jib crane was installed in isolation room. The in-cell crane mainly consists of hoist, driving unit for travelling motion, operation and control equipment and other mechanical equipment. The in-cell crane is specially design to maximize its access area since the inside hot-cell is not accessed by workers. And the manual lifting and travelling devices are attached in the in-cell crane for the electric power failure accident as a fail safe design. The crane gate, which is used for closing the open space above the inter-cell wall, was designed to sufficiently guarantee radiation shielding safety. To investigate the structural safety of the in-cell crane and the crane gate, seismic analysis, structural analysis, modal analysis and stress analysis were performed. The results showed that a structural safety is sufficiently assured under various loading conditions. After installation was completed, the in-cell crane and the jib crane were inspected and tested by Korea Occupational Safety and Health Agency (KOSHA), and received the approval certificates of these cranes from KOSHA.

  20. Acyl-ACP substrate recognition in Burkholderia mallei BmaI1 acyl-homoserine lactone synthase.

    Science.gov (United States)

    Montebello, Aubrey N; Brecht, Ryan M; Turner, Remington D; Ghali, Miranda; Pu, Xinzhu; Nagarajan, Rajesh

    2014-10-07

    The acyl-homoserine lactone (AHL) autoinducer mediated quorum sensing regulates virulence in several pathogenic bacteria. The hallmark of an efficient quorum sensing system relies on the tight specificity in the signal generated by each bacterium. Since AHL signal specificity is derived from the acyl-chain of the acyl-ACP (ACP = acyl carrier protein) substrate, AHL synthase enzymes must recognize and react with the native acyl-ACP with high catalytic efficiency while keeping reaction rates with non-native acyl-ACPs low. The mechanism of acyl-ACP substrate recognition in these enzymes, however, remains elusive. In this study, we investigated differences in catalytic efficiencies for shorter and longer chain acyl-ACP substrates reacting with an octanoyl-homoserine lactone synthase Burkholderia mallei BmaI1. With the exception of two-carbon shorter hexanoyl-ACP, the catalytic efficiencies of butyryl-ACP, decanoyl-ACP, and octanoyl-CoA reacting with BmaI1 decreased by greater than 20-fold compared to the native octanoyl-ACP substrate. Furthermore, we also noticed kinetic cooperativity when BmaI1 reacted with non-native acyl-donor substrates. Our kinetic data suggest that non-native acyl-ACP substrates are unable to form a stable and productive BmaI1·acyl-ACP·SAM ternary complex and are thus effectively discriminated by the enzyme. These results offer insights into the molecular basis of substrate recognition for the BmaI1 enzyme.

  1. Dimethylformamide as a cryoprotectant for canine semen diluted and frozen in ACP-106C.

    Science.gov (United States)

    Mota Filho, A C; Teles, C H A; Jucá, R P; Cardoso, J F S; Uchoa, D C; Campello, C C; Silva, A R; Silva, L D M

    2011-10-15

    The objective was to assess the effect of adding various concentrations of dimethylformamide on characteristics of canine semen diluted in powdered coconut water (ACP-106C; ACP Biotecnologia, Fortaleza, CE, Brazil) and frozen at -196°C. Fifteen ejaculates were collected by manual stimulation from five adult Boxer dogs. The sperm-rich fraction was diluted in ACP-106C (ACP Biotecnologia) containing 10% egg yolk and divided into four aliquots. The cryoprotectants used for each aliquot were 6% glycerol (control group; CG) or 2%, 4%, or 6% dimethylformamide (DF2, DF4, and DF6, respectively). After thawing, total motility (mean ± SEM) for CG (58.4 ± 24.6) was higher (P Biotecnologia) and 10% egg yolk as a diluent, yielded unsatisfactory in vitro results for freezing canine semen. Copyright © 2011 Elsevier Inc. All rights reserved.

  2. U.S. Department of Energy photovoltaic energy program contract summary, fiscal year 1999

    Energy Technology Data Exchange (ETDEWEB)

    Surek, T.; Hansen, A.

    2000-02-17

    This report summarizes the in-house and subcontracted research and development (R and D) activities under the National Center for Photovoltaics (NCPV) and US Department of Energy (DOE) National Photovoltaics Program from October 1, 1998, through September 30, 1999 (FY 1999). The mission of the DOE National Photovoltaics Program is to make PV a significant part of the domestic economy as an industry and an energy resource. The two primary goals of the national program are to (1) maintain the US industry's world leadership in research and technology development and (2) help the US industry remain a major, profitable force in the world market. The NCPV is part of the National PV Program and provides leadership and support to the national program toward achieving its mission and goals.

  3. 7 CFR Exhibit E to Subpart E of... - List of Regional Offices, Office of Federal Contract Compliance Programs (OFCCP), U.S. Department...

    Science.gov (United States)

    2010-01-01

    ... Compliance Programs (OFCCP), U.S. Department of Labor (USDL) E Exhibit E to Subpart E of Part 1901... REGULATIONS PROGRAM-RELATED INSTRUCTIONS Civil Rights Compliance Requirements Pt. 1901, Subpt. E, Exh. E Exhibit E to Subpart E of Part 1901—List of Regional Offices, Office of Federal Contract Compliance...

  4. Self-Etch Adhesive as a Carrier for ACP Nanoprecursors to Deliver Biomimetic Remineralization.

    Science.gov (United States)

    Wu, Zhifang; Wang, Xiaokan; Wang, Zhe; Shao, Changyu; Jin, Xiaoting; Zhang, Leiqing; Pan, Haihua; Tang, Ruikang; Fu, Baiping

    2017-05-31

    Lab biomineralization should be carried out in an actual clinical practice. This study evaluated self-etch adhesive as a carrier for amorphous calcium phosphate (ACP) nanoprecursors to continuously deliver biomimetic remineralization of self-assembly type I collagen and demineralized dentin. Si-containing ACP particles (Si-ACP) stabilized with polyaspartic acid (PAsp) were synthesized and characterized by transmission electron microscopy (TEM), scanning electron microscopy-energy-dispersive X-ray spectroscopy, Fourier transform infrared analysis, X-ray powder diffractometry, and X-ray phototelectron spectroscopy. The biomimetic remineralization of single-layer reconstituted type I collagen fibrils and demineralized dentin was analyzed by using two one-bottle self-etch dentin adhesives (Clearfil S3 Bond (S3), Kurraray-Noritake; Adper Easy One (AEO), 3 M ESPE) as a carrier loaded (or not, in the case of the control) with 25 wt % of Si-ACP particles. In vitro cytotoxicity assessed by the Cell Counting Kit-8 indicated that the Si-ACP particles had no adverse effect on cell viability. The capacity for Ca and P ions release from cured Si-ACP-containing adhesives (S3, AEO) was evaluated by inductively coupled plasma-atomic emission spectrometry, revealing the successively increasing release of Ca and P ions for 28 days. The intra- and extrafibrillar remineralization of type I collagen and demineralized dentin was confirmed by TEM and selected-area electron diffraction when the adhesives were used as a carrier loaded with Si-ACP particles. Therefore, we propose self-etch adhesive as a novel carrier for ACP nanoprecursors to continuously deliver biomimetic remineralization.

  5. Effects of training programs based on ipsilateral voluntary and stimulated contractions on muscle strength and monopedal postural control of the contralateral limb.

    Science.gov (United States)

    Kadri, Mohamed Abdelhafid; Noé, Frederic; Nouar, Merbouha Boulahbel; Paillard, Thierry

    2017-07-03

    To compare the effects of unilateral strength training by stimulated and voluntary contractions on muscle strength and monopedal postural control of the contralateral limb. 36 non-active healthy male subjects were recruited and split randomly into three groups. Two groups of 12 subjects took part in a strength-training program (3 sessions a week over 8 weeks) comprising 43 contractions of the quadriceps femoris of the ipsilateral limb (at 20% of the MVC). One group carried out voluntary contractions exclusively (VOL group), while the other group benefited exclusively from electro-induced contractions (NMES group). The other 12 subjects formed the control (CON) group. Assessments of MVC and monopedal postural control in static and dynamic postural tasks were performed with the ipsilateral (ISPI) and contralateral (CONTRA) limbs before (PRE) and after (POST) completion of the training program. After the training program, the MVC of the IPSI and CONTRA limbs increased similarly for both experimental groups (VOL and NMES). There were no significant improvements of monopedal postural control for the IPSI or CONTRA limbs in either the VOL or NMES experimental group. No change was observed for the CON group over the protocol period. The purposed training program with NMES vs VOL contractions induced strength gains but did not permit any improvement of contralateral monopedal postural control in healthy young subjects. This has potential for therapeutic application and allows clinicians to focus their training programs on dynamic and poly-articular exercises to improve the postural control in young subjects.

  6. In situ effect of CPP-ACP chewing gum upon erosive enamel loss

    Directory of Open Access Journals (Sweden)

    Catarina Ribeiro Barros de ALENCAR

    Full Text Available Abstract Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP is able to increase salivary calcium and phosphate levels at an acidic pH. Previous studies demonstrated that a CPP-ACP chewing gum was able to enhance the re-hardening of erosion lesions, but could not diminish enamel hardness loss. Therefore, there is no consensus regarding the effectiveness of CPP-ACP on dental erosion. Objective This in situ study investigated the ability of a CPP-ACP chewing gum in preventing erosive enamel loss. Material and Methods: During three experimental crossover phases (one phase per group of seven days each, eight volunteers wore palatal devices with human enamel blocks. The groups were: GI – Sugar free chewing gum with CPP-ACP; GII – Conventional sugar free chewing gum; and GIII – No chewing gum (control. Erosive challenge was extraorally performed by immersion of the enamel blocks in cola drink (5 min, 4x/day. After each challenge, in groups CPP and No CPP, volunteers chewed one unit of the corresponding chewing gum for 30 minutes. Quantitative analysis of enamel loss was performed by profilometry (µm. Data were analyzed by Repeated-Measures ANOVA and Tukey’s test (p0.05. Conclusion The CPP-ACP chewing gum was not able to enhance the anti-erosive effect of conventional chewing gum against enamel loss.

  7. In situ effect of CPP-ACP chewing gum upon erosive enamel loss

    Science.gov (United States)

    de ALENCAR, Catarina Ribeiro Barros; de OLIVEIRA, Gabriela Cristina; MAGALHÃES, Ana Carolina; BUZALAF, Marília Afonso Rabelo; MACHADO, Maria Aparecida de Andrade Moreira; HONÓRIO, Heitor Marques; RIOS, Daniela

    2017-01-01

    Abstract Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) is able to increase salivary calcium and phosphate levels at an acidic pH. Previous studies demonstrated that a CPP-ACP chewing gum was able to enhance the re-hardening of erosion lesions, but could not diminish enamel hardness loss. Therefore, there is no consensus regarding the effectiveness of CPP-ACP on dental erosion. Objective This in situ study investigated the ability of a CPP-ACP chewing gum in preventing erosive enamel loss. Material and Methods: During three experimental crossover phases (one phase per group) of seven days each, eight volunteers wore palatal devices with human enamel blocks. The groups were: GI – Sugar free chewing gum with CPP-ACP; GII – Conventional sugar free chewing gum; and GIII – No chewing gum (control). Erosive challenge was extraorally performed by immersion of the enamel blocks in cola drink (5 min, 4x/day). After each challenge, in groups CPP and No CPP, volunteers chewed one unit of the corresponding chewing gum for 30 minutes. Quantitative analysis of enamel loss was performed by profilometry (µm). Data were analyzed by Repeated-Measures ANOVA and Tukey’s test (p0.05). Conclusion The CPP-ACP chewing gum was not able to enhance the anti-erosive effect of conventional chewing gum against enamel loss. PMID:28678944

  8. X-Ray Crystallographic Studies on Butyryl-ACP Reveal Flexibility of the Structure around a Putative Acyl Chain Binding Site

    NARCIS (Netherlands)

    Roujeinikova, A.; Baldock, C.; Simon, W.J.; Gilroy, J.; Baker, P.J.; Stuitje, A.R.; Rice, D.W.; Slabas, A.R.; Rafferty, J.B.

    2002-01-01

    Acyl carrier protein (ACP) is an essential cofactor in biosynthesis of fatty acids and many other reactions that require acyl transfer steps. We have determined the first crystal structures of an acylated form of ACP from E. coli, that of butyryl-ACP. Our analysis of the molecular surface of ACP

  9. Platensimycin activity against mycobacterial beta-ketoacyl-ACP synthases.

    Directory of Open Access Journals (Sweden)

    Alistair K Brown

    2009-07-01

    Full Text Available There is an urgent need for the discovery and development of new drugs against Mycobacterium tuberculosis, the causative agent of tuberculosis, especially due to the recent emergence of multi-drug and extensively-drug resistant strains. Herein, we have examined the susceptibility of mycobacteria to the natural product platensimycin.We have demonstrated that platensimycin has bacteriostatic activity against the fast growing Mycobacterium smegmatis (MIC = 14 microg/ml and against Mycobacterium tuberculosis (MIC = 12 microg/ml. Growth in the presence of paltensimycin specifically inhibited the biosynthesis of mycolic acids suggesting that the antibiotic targeted the components of the mycolate biosynthesis complex. Given the inhibitory activity of platensimycin against beta-ketoacyl-ACP synthases from Staphylococcus aureus, M. tuberculosis KasA, KasB or FabH were overexpressed in M. smegmatis to establish whether these mycobacterial KAS enzymes were targets of platensimycin. In M. smegmatis overexpression of kasA or kasB increased the MIC of the strains from 14 microg/ml, to 30 and 124 microg/ml respectively. However, overexpression of fabH on did not affect the MIC. Additionally, consistent with the overexpression data, in vitro assays using purified proteins demonstrated that platensimycin inhibited Mt-KasA and Mt-KasB, but not Mt-FabH.Our results have shown that platensimycin is active against mycobacterial KasA and KasB and is thus an exciting lead compound against M. tuberculosis and the development of new synthetic analogues.

  10. Characterization of soluble acyl-ACP desaturases from Camelina sativa, Macadamia tetraphylla and Dolichandra unguis-cati.

    Science.gov (United States)

    Rodríguez, Manuel Fernando Rodríguez; Sánchez-García, Alicia; Salas, Joaquín J; Garcés, Rafael; Martínez-Force, Enrique

    2015-04-15

    Acyl-acyl carrier protein (ACP) desaturases (EC 1.14.19.2) are soluble enzymes that catalyse the insertion of a double bond into saturated fatty acid bound in saturated acyl chains bound to ACP in higher plants, producing cis-monounsaturated fatty acids. Three types of soluble acyl-ACP desaturases have been described: Δ(9)-acyl-ACP, Δ(6)-acyl-ACP and Δ(4)-acyl-ACP desaturases, which differ in the substrate specificity and the position in which the double bond is introduced. In the present work, Camelina sativa (CsSAD), Macadamia tetraphylla (MtSAD) and Dolichandra unguis-cati (DuSAD) desaturases were cloned, sequenced and characterized. Single copies of CsSAD, MtSAD and DuSAD with three, one and two different alleles, respectively, were found. The corresponding mature proteins were heterologously expressed in Escherichia coli for biochemical characterization in protein extracts. The recombinant CsSAD enzyme showed 300-fold higher specificity towards 18:0-ACP than 16:0-ACP. Similar profile exhibited MtSAD although the differences in the specificity were lower, around 170-fold higher for 18:0-ACP than 16:0-ACP. Furthermore, DuSAD presented a profile showing preference towards 16:0-ACP against 18:0-ACP, around twice more, being so a Δ(9) palmitoyl-ACP desaturase. Also, we reported the expression profile of CsSAD, which showed the highest levels of expression in expanding tissues that typically are very active in lipid biosynthesis such as developing seed endosperm. Moreover, the possibility to express a new desaturase in C. sativa (oilseed crop that store high levels of oil and is easy to transform) to create a new line rich in short monounsaturated fatty acid is discussed. Copyright © 2015 Elsevier GmbH. All rights reserved.

  11. 75 FR 62257 - Women-Owned Small Business Federal Contract Program

    Science.gov (United States)

    2010-10-07

    ... from gender discrimination. The SBO database in the RAND Report does not distinguish between WOSBs and... that each Federal agency must certify that it had engaged in discrimination against WOSBs in order for... opposed gender based set asides, believed that the program creates an artificial advantage for a certain...

  12. Premature Contractions

    Science.gov (United States)

    ... Peripheral Artery Disease Venous Thromboembolism Aortic Aneurysm More Premature Contractions - PACs and PVCs Updated:Dec 15,2016 ... You felt this more-forceful beat. Types of premature contractions Premature atrial contractions (PACs) start in the ...

  13. 78 FR 52907 - Fees for Reviews of the Rule Enforcement Programs of Designated Contract Markets and Registered...

    Science.gov (United States)

    2013-08-27

    ... two.\\3\\ \\1\\ NFA is the only registered futures association. \\2\\ See section 237 of the Futures Trading... annual costs for all DCMs. NFA has no contracts traded; hence, its fee is based simply on costs for the... contracts traded is not applicable to NFA because it is not a DCM and has no contracts traded. The...

  14. Effect of CPP/ACP on Initial Bioadhesion to Enamel and Dentin In Situ

    Directory of Open Access Journals (Sweden)

    Susann Grychtol

    2014-01-01

    Full Text Available The present in situ study investigated the influence of a preparation containing CPP/ACP (caseinphosphopeptide-amorphous calcium phosphate (GC Tooth mousse on initial bacterial colonization of enamel and dentin. Therefore, pellicle formation was performed in situ on bovine enamel and dentin specimens fixed to individual upper jaw splints worn by 8 subjects. After 1 min of pellicle formation GC Tooth mousse was used according to manufacturer’s recommendations. Rinses with chlorhexidine served as positive controls. Specimens carried without any rinse served as negative controls. After 8 h overnight exposure of the splints, bacterial colonization was quantified by fluorescence microscopy (DAPI and BacLight live/dead staining. Additionally, the colony forming units (CFU were determined after desorption. Furthermore, the effects on Streptococcus mutans bacteria were tested in vitro (BacLight. There was no significant impact of CPP/ACP on initial bacterial colonization proved with DAPI and BacLight. Determination of CFU showed statistical significance for CPP/ACP to reduce bacterial adherence on enamel. The in vitro investigation indicated no antimicrobial effects for CPP/ACP on Streptococcus mutans suspension. Under the chosen conditions, CPP/ACP (GC Tooth mousse had no significant impact on initial biofilm formation on dental hard tissues. The tested preparation cannot be recommended for biofilm management.

  15. iACP: a sequence-based tool for identifying anticancer peptides.

    Science.gov (United States)

    Chen, Wei; Ding, Hui; Feng, Pengmian; Lin, Hao; Chou, Kuo-Chen

    2016-03-29

    Cancer remains a major killer worldwide. Traditional methods of cancer treatment are expensive and have some deleterious side effects on normal cells. Fortunately, the discovery of anticancer peptides (ACPs) has paved a new way for cancer treatment. With the explosive growth of peptide sequences generated in the post genomic age, it is highly desired to develop computational methods for rapidly and effectively identifying ACPs, so as to speed up their application in treating cancer. Here we report a sequence-based predictor called iACP developed by the approach of optimizing the g-gap dipeptide components. It was demonstrated by rigorous cross-validations that the new predictor remarkably outperformed the existing predictors for the same purpose in both overall accuracy and stability. For the convenience of most experimental scientists, a publicly accessible web-server for iACP has been established at http://lin.uestc.edu.cn/server/iACP, by which users can easily obtain their desired results.

  16. Cryopreservation of canine epididymal sperm using ACP-106c and TRIS.

    Science.gov (United States)

    Mota Filho, Antônio Cavalcante; Silva, Herlon Victor Rodrigues; Nunes, Thalles Gothardo Pereira; de Souza, Mírley Barbosa; de Freitas, Luana Azevedo; de Araújo, Airton Alencar; da Silva, Lúcia Daniel Machado

    2014-08-01

    The objective was to cryopreserve sperm recovered from the canine epididymal cauda immediately after an orchiectomy. The sperm was stored for 12h at 4 °C using ACP-106c and TRIS as extenders. Sixty adult male dogs were used. The testis-epididymis complex (TEC) was removed, immersed in 0.9% saline and transported to the laboratory. The 60 TEC were divided into groups according to the 4 °C cooling time (0 h or 12 h) and according to the extender used for sperm recovery (ACP-106c or TRIS), forming 4 experimental groups: G0h-ACP, G12h-ACP, G0h-TRIS and G12h-TRIS. The sperm were recovered from the epididymal cauda using the retrograde flow technique. Next, 1.0 mL of ACP-106c or 1.0 mL of TRIS (preheated to 37 °C for 5 min) was added to the sperm of each epididymis. One week later, the sperm was thawed at 37 °C for 1 min, and its morphology, functionality and total and progressive sperm motilities were analyzed. Other parameters were obtained by Computer Assisted Semen Analysis (CASA). The data were submitted to multivariate analysis of variance (MANOVA) (Psperm motility was observed after 12h of cooling for both extenders (Pepididymal sperm, and the freezing procedure must be performed immediately after sperm recovery. Copyright © 2014 Elsevier Inc. All rights reserved.

  17. Exploration of Methods Used by Pharmacy Professional Programs to Contract with Experiential Practice Sites.

    Science.gov (United States)

    Brownfield, Angela; Garavalia, Linda; Gubbins, Paul O; Ruehter, Valerie

    2016-03-25

    Objective. To explore methods used by pharmacy programs to attract and sustain relationships with preceptors and experiential practice sites. Methods. Interviews with eight focus groups of pharmacy experiential education experts (n=35) were conducted at two national pharmacy meetings. A semi-structured interview guide was used. Focus group interviews were recorded, transcribed verbatim, and categorically coded independently by two researchers. Codes were compared, consensus was reached through discussion, and two experiential education experts assisted with interpretation of the coded data. Results. Six themes emerged consistently across focus groups: a perceived increase in preceptor compensation, intended vs actual use of payments by sites, concern over renegotiation of established compensation, costs and benefits of experiential students, territorialism, and motives. Conclusion. Fostering a culture of collaboration may counteract potentially competitive strategies to gain sites. Participants shared a common interest in providing high-quality experiential learning where sites and preceptors participated for altruistic reasons, rather than compensation.

  18. Effect of CPP-ACP paste on tooth mineralization: an FE-SEM study.

    Science.gov (United States)

    Oshiro, Maki; Yamaguchi, Kanako; Takamizawa, Toshiki; Inage, Hirohiko; Watanabe, Takayuki; Irokawa, Atsushi; Ando, Susumu; Miyazaki, Masashi

    2007-06-01

    Milk and milk products, such as cheese, have been shown to exhibit anticariogenic properties in human and animal models. CPP-ACP shows an anti-caries effect by suppressing demineralization, enhancing remineralization, or possibly a combination of both. The purpose of this study was to evaluate the effect of CPP-ACP paste on demineralization by observing the treated tooth surface using an FE-SEM. The specimens were prepared by cutting enamel and dentin of bovine teeth into blocks. A few specimens were stored in 0.1 M lactic acid buffer solution for 10 min and then in artificial saliva (negative control). The remaining specimens were stored in a 10 times-diluted solution of CPP-ACP paste or a placebo paste containing no CPP-ACP for 10 min, followed by 10 min immersion in a demineralizing solution (pH = 4.75, Ca) twice a day before storage in artificial saliva. After treatment of the specimens for 3, 7, 21 and 28 days, they were fixed in 2.5% glutaraldehyde in cacodylate buffer solution, dehydrated in ascending grades of tert-butyl alcohol, and then transferred to a critical-point dryer. The surfaces were coated with a thin film of Au in a vacuum evaporator, and were observed under field emission-scanning electron microscopy (FE-SEM). The SEM observations revealed different morphological features brought about by the various storage conditions. Demineralization of the enamel and dentin surfaces was more pronounced with the longer test period in the control and negative control specimens. On the other hand, enamel and dentin specimens treated with CPP-ACP paste revealed slight changes in their morphological features. From the morphological observations of the enamel and dentin surfaces, it could be considered that the CPP-ACP paste might prevent demineralization of the tooth structure.

  19. Decisions on Energy Demand Response Option Contracts in Smart Grids Based on Activity-Based Costing and Stochastic Programming

    Directory of Open Access Journals (Sweden)

    Alfred J. Hildreth

    2013-01-01

    Full Text Available Smart grids enable a two-way energy demand response capability through which a utility company offers its industrial customers various call options for energy load curtailment. If a customer has the capability to accurately determine whether to accept an offer or not, then in the case of accepting an offer, the customer can earn both an option premium to participate, and a strike price for load curtailments if requested. However, today most manufacturing companies lack the capability to make the correct contract decisions for given offers. This paper proposes a novel decision model based on activity-based costing (ABC and stochastic programming, developed to accurately evaluate the impact of load curtailments and determine as to whether or not to accept an energy load curtailment offer. The proposed model specifically targets state-transition flexible and Quality-of-Service (QoS flexible energy use activities to reduce the peak energy demand rate. An illustrative example with the proposed decision model under a call-option based energy demand response scenario is presented. As shown from the example results, the proposed decision model can be used with emerging smart grid opportunities to provide a competitive advantage to the manufacturing industry.

  20. The effect of CPP-ACP containing fluoride on Streptococcus mutans adhesion and enamel roughness

    Directory of Open Access Journals (Sweden)

    Yulita Kristanti

    2013-12-01

    Full Text Available Background: Direct contact between the bleaching agent and the enamel surface results in demineralization, alteration in surface roughness and bacterial adhesion. Many studies try to minimize this side effect through different way. Purpose: The aim of this study was to determined the effect of Calcium Phospho Peptide-Amorphous Calcium Phosphate (CPP-ACP containing fluoride application before and after bleaching procedure on the adhesion of S. Mutans and enamel roughness. Methods: The samples were 6 teeth which were divided into 4 groups, and each tooth was cut into four pieces. Group A and C were treated with CPP-ACP after bleaching, while group B and D were treated with CPP-ACP before and after bleaching. CPP-ACP used in group C and D was the one that contain fluoride. After treatment, all samples were sterilized, immersed in steril human saliva for one hour, then immersed into S. mutans suspension of 108 CFU. Samples were incubated overnight. On the next day the samples were put into steril BHI and vortexed for one minute to detach the bacteria. Fifteen ml BHI containing bacteria was poured into TYS agar then incubated 37°Cfor 48 hours. Bacterial colony was counted with colony counter. The SEM examination was done on all samples. Results: Application of desensitizing agent reduced the S.mutans adhesion significantly among groups (p<0.05 except between group A and C. SEM evaluation revealed significant differences among groups. Conclusion: The application of CPP-ACP containing fluoride before and after bleaching was effective to reduce the accumulation of S.mutans colony and enamel roughness.Latar belakang: Kontak langsung antara bahan bleaching dan permukaan enamel menyebabkan demineralisasi, perubahan kekasaran permukaan dan berpengaruh terhadap banyaknya bakteri Streptococcus mutans (S. mutans yang melekat. Banyak peneliti mencoba meminimalkan efek samping ini dengan cara yang beragam. Tujuan: Penelitian ini bertujuan untuk meneliti efek

  1. 77 FR 26672 - Fees for Reviews of the Rule Enforcement Programs of Designated Contract Markets and Registered...

    Science.gov (United States)

    2012-05-07

    ... two.\\3\\ \\1\\ NFA is the only registered futures association. \\2\\ See section 237 of the Futures Trading... annual costs for all DCMs. NFA has no contracts traded; hence, its fee is based simply on costs for the..., the alternative calculation based on contracts traded is not applicable to NFA because it is not a DCM...

  2. Managing Contract Training Programs: Progress and Proposals. Institute for Studies in Higher Education Policy Paper No. 2.

    Science.gov (United States)

    Deegan, William L.

    An overview is provided of community college involvement in providing job training for industry on a contract basis. Part 1 provides background on the changing role of community colleges and the introduction of contract training as a means of addressing the growing need of organizations to train and retrain staff. Part 2 offers a national…

  3. 48 CFR 822.305 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause. 822.305... PROGRAMS APPLICATION OF LABOR LAWS TO GOVERNMENT ACQUISITIONS Contract Work Hours and Safety Standards Act 822.305 Contract clause. The contracting officer shall insert the clause at 852.222-70, Contract Work...

  4. Assessment of occlusion curriculum in predoctoral dental education: report from ACP Task Force on Occlusion Education.

    Science.gov (United States)

    Lee, Damian J; Wiens, Jonathan P; Ference, John; Donatelli, David; Smith, Rick M; Dye, Bryan D; Obrez, Ales; Lang, Lisa A

    2012-10-01

    The purposes of this report were to (1) assess the current occlusion curriculum in the predoctoral prosthodontic education of US dental institutions and (2) to examine the opinions of faculty, course directors, and program directors on the contents of occlusion curriculum. The Task Force on Occlusion Education from the American College of Prosthodontists (ACP) conducted two surveys using a web-based survey engine: one to assess the current status of occlusion education in predoctoral dental education and another to examine the opinions of faculty and course directors on the content of occlusion curriculum. The sections in the surveys included demographic information, general curriculum information, occlusion curriculum for dentate patients, occlusion curriculum for removable prosthodontics, occlusion curriculum for implant prosthodontics, temporomandibular disorder (TMD) curriculum, teaching philosophy, concepts taught, and methods of assessment. The results from the surveys were compiled and analyzed using descriptive statistics. The results from the two surveys on general concepts taught in occlusion curriculum were sorted and compared for discrepancies. According to the predoctoral occlusion curriculum surveys, canine guidance was preferred for dentate patients, fixed prosthodontics, and fixed implant prosthodontics. Bilateral balanced occlusion was preferred for removable prosthodontics and removable implant prosthodontics. There were minor differences between the two surveys regarding the occlusion concepts being taught and the opinions of faculty members teaching occlusion. Two surveys were conducted regarding the current concepts being taught in occlusion curriculum and the opinions of educators on what should be taught in occlusion curriculum. An updated and clearly defined curriculum guideline addressing occlusion in fixed prosthodontics, removable prosthodontics, implant prosthodontics, and TMD is needed. © 2012 by the American College of Prosthodontists.

  5. Recovery and cryopreservation of epididymal sperm from agouti (Dasiprocta aguti) using powdered coconut water (ACP-109c) and Tris extenders.

    Science.gov (United States)

    Silva, M A; Peixoto, G C X; Santos, E A A; Castelo, T S; Oliveira, M F; Silva, A R

    2011-10-01

    The objective was to compare the use of powdered coconut water (ACP-109c; ACP Biotecnologia, Fortaleza, CE, Brazil) and Tris extenders for recovery and cryopreservation of epididymal sperm from agouti. The caudae epididymus and proximal ductus deferens from 10 sexually mature agoutis were subjected to retrograde washing using ACP-109c (ACP Biotecnologia) or Tris. Epididymal sperm were evaluated for motility, vigor, sperm viability, membrane integrity, and morphology. Samples were centrifuged, and extended in the same diluents plus egg yolk (20%) and glycerol (6%), frozen in liquid nitrogen, and subsequently thawed at 37°C for 1 min, followed by re-evaluation of sperm characteristics. The two extenders were similarly efficient for epididymal recovery, with regard to the number and quality of sperm recovered. However, for both extenders, sperm quality decreased (P Biotecnologia) group, which was significantly better than 9.7 ± 2.6% motile sperm with 1.2 ± 0.3 vigor in Tris. In conclusion, agouti epididymal sperm were successfully recovered using either ACP-109c (ACP Biotecnologia) or Tris extenders; however, ACP-109c (ACP Biotecnologia) was a significantly better extender for processing and cryopreserving these sperm. Copyright © 2011 Elsevier Inc. All rights reserved.

  6. Acyl carrier proteins from sunflower (Helianthus annuus L.) seeds and their influence on FatA and FatB acyl-ACP thioesterase activities.

    Science.gov (United States)

    Aznar-Moreno, Jose A; Venegas-Calerón, Mónica; Martínez-Force, Enrique; Garcés, Rafael; Salas, Joaquín J

    2016-08-01

    The kinetics of acyl-ACP thioesterases from sunflower importantly changed when endogenous ACPs were used. Sunflower FatB was much more specific towards saturated acyl-ACPs when assayed with them. Acyl carrier proteins (ACPs) are small (~9 kDa), soluble, acidic proteins involved in fatty acid synthesis in plants and bacteria. ACPs bind to fatty acids through a thioester bond, generating the acyl-ACP lipoproteins that are substrates for fatty acid synthase (FAS) complexes, and that are required for fatty acid chain elongation, acting as important intermediates in de novo fatty acid synthesis in plants. Plants, usually express several ACP isoforms with distinct functionalities. We report here the cloning of three ACPs from developing sunflower seeds: HaACP1, HaACP2, and HaACP3. These proteins were plastidial ACPs expressed strongly in seeds, and as such they are probably involved in the synthesis of sunflower oil. The recombinant sunflower ACPs were expressed in bacteria but they were lethal to the prokaryote host. Thus, they were finally produced using the GST gene fusion system, which allowed the apo-enzyme to be produced and later activated to the holo form. Radiolabelled acyl-ACPs from the newly cloned holo-ACP forms were also synthesized and used to characterize the activity of recombinant sunflower FatA and FatB thioesterases, important enzymes in plant fatty acids synthesis. The activity of these enzymes changed significantly when the endogenous ACPs were used. Thus, FatA importantly increased its activity levels, whereas FatB displayed a different specificity profile, with much high activity levels towards saturated acyl-CoA derivatives. All these data pointed to an important influence of the ACP moieties on the activity of enzymes involved in lipid synthesis.

  7. The effect of CPP-ACP paste on the surface hardness of glass ionomer cement when immersed in orange juice

    Science.gov (United States)

    Nadia, A. A.; Eriwati, Y. K.; Damiyanti, M.

    2017-08-01

    This study aims to identify the effect of CPP-ACP paste on the surface hardness of glass ionomer cement (GIC) when immersed in orange juice. Eighteen specimens of Fuji IX GIC were divided into three groups: no CPP-ACP added (group A); CPP-ACP applied for three minutes (group B); and CPP-ACP applied for 30 minutes (group C). Specimens were immersed in orange juice and tested for surface hardness using a Vickers hardness tester. Data were analyzed using the one-way ANOVA (p = <0.05). Group A resulted in a 31.77 ± 0.77 Vickers Hardness Number (VHN), group B in a 42.97 ± 1.08 VHN, and group C in a 51.92 ± 0.27 VHN. It was concluded that application of CPP-ACP paste for 30 minutes is effective in preventing a decrease in the surface hardness of GIC due to orange juice consumption.

  8. Expression and developmental function of the 3-ketoacyl-ACP synthase2 gene in Arabidopsis thaliana.

    Science.gov (United States)

    Hakozaki, Hirokazu; Park, Jong-In; Endo, Makoto; Takada, Yoshinobu; Kazama, Tomohiko; Takeda, Yoshimitsu; Suzuki, Go; Kawagishi-Kobayashi, Makiko; Watanabe, Masao

    2008-04-01

    The 3-ketoacyl-ACP synthase (KAS) II is a fatty-acid-related enzyme which catalyzes the elongation of 16:0-acyl carrier protein (ACP) to 18:0-ACP in plastids. The fatty acid biosynthesis 1-1 (fab1-1) mutant of Arabidopsis thaliana is partially deficient in its activity of Arabidopsis thaliana 3-ketoacyl-ACP synthase 2 (AtKAS2), and its phenotype has been intensively studied in connection with the chilling resistance and fatty acid composition. In this study, we used the T-DNA insertion mutant of AtKAS2 to examine its possible role in plant development. Reverse transcription (RT)-PCR showed that the AtKAS2 gene was expressed in various plant organs, except for roots, and was highly expressed in siliques. The fusion of beta-glucuronidase (GUS) to the AtKAS2 promoter demonstrated that the promoter was active in various tissues such as embryos, stomatal guard cells, inflorescences and pollen grains. We were not able to identify atkas2 homozygous mutant adult plants in heterozygous mutant progeny. Phenotypic and genetic analyses showed that disruption of the AtKAS2 by T-DNA insertion caused embryo lethality, and the development of the embryos was arrested at the globular stage. Taken together, our results suggest that AtKAS2 is required for embryo development in Arabidopsis during the transition from the globular to the heart stage.

  9. Isolation of a kernel oleoyl-ACP thioesterase gene from the oil palm ...

    African Journals Online (AJOL)

    We have isolated a cDNA clone from the developing kernel of the oil palm Elaeis guineensis which encodes a thioesterase enzyme. Its highest homology was to the Brassica napus oleoyl-ACP thioesterase with which it had 72% homology at the nucleotide level, over the coding region examined, and 83% identity (90% ...

  10. Polymorphic Contracts

    Science.gov (United States)

    Belo, João Filipe; Greenberg, Michael; Igarashi, Atsushi; Pierce, Benjamin C.

    Manifest contracts track precise properties by refining types with predicates - e.g., {x : Int |x > 0 } denotes the positive integers. Contracts and polymorphism make a natural combination: programmers can give strong contracts to abstract types, precisely stating pre- and post-conditions while hiding implementation details - for example, an abstract type of stacks might specify that the pop operation has input type {x :α Stack |not ( empty x )} . We formalize this combination by defining FH, a polymorphic calculus with manifest contracts, and establishing fundamental properties including type soundness and relational parametricity. Our development relies on a significant technical improvement over earlier presentations of contracts: instead of introducing a denotational model to break a problematic circularity between typing, subtyping, and evaluation, we develop the metatheory of contracts in a completely syntactic fashion, omitting subtyping from the core system and recovering it post facto as a derived property.

  11. Electrical contracting

    CERN Document Server

    Neidle, Michael

    2013-01-01

    Electrical Contracting, Second Edition is a nine-chapter text guide for the greater efficiency in planning and completing installations for the design, installation and control of electrical contracts. This book starts with a general overview of the efficient cabling and techniques that must be employed for safe wiring design, as well as the cost estimation of the complete electrical contract. The subsequent chapters are devoted to other electrical contracting requirements, including electronic motor control, lighting, and electricity tariffs. A chapter focuses on the IEE Wiring Regulations an

  12. 48 CFR 1319.812 - Contract administration.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract administration. 1319.812 Section 1319.812 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Contracting With the Small Business Administration (the 8(a) Program) 1319.812 Contract administration. Awards unde...

  13. 48 CFR 1219.812 - Contract administration.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract administration. 1219.812 Section 1219.812 Federal Acquisition Regulations System DEPARTMENT OF TRANSPORTATION SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Contracting with the Small Business Administration (The 8(a) Program) 1219.812 Contract administration. (d)...

  14. 48 CFR 819.709 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause. 819.709... PROGRAMS SMALL BUSINESS PROGRAMS The Small Business Subcontracting Program 819.709 Contract clause. The contracting officer shall insert VAAR clause 852.219-9, Small Business Subcontracting Plan Minimum...

  15. Does Teaching Experience Matter? Examining Biology Teachers' Prior Knowledge for Teaching in an Alternative Certification Program

    Science.gov (United States)

    Friedrichsen, Patricia J.; Abell, Sandra K.; Pareja, Enrique M.; Brown, Patrick L.; Lankford, Deanna M.; Volkmann, Mark J.

    2009-01-01

    Alternative certification programs (ACPs) have been proposed as a viable way to address teacher shortages, yet we know little about how teacher knowledge develops within such programs. The purpose of this study was to investigate prior knowledge for teaching among students entering an ACP, comparing individuals with teaching experience to those…

  16. Transition metal HE`s - VII ACP. Progress report, August 1971--October 1971

    Energy Technology Data Exchange (ETDEWEB)

    Clink, G.L.

    1998-12-31

    Physical and physicochemical properties of hexaamminechromium III perchlorate (ACP) were investigated to determine its potentiality for HE and/or HE component application. Physicochemical properties obtained through investigation of isothermally aged ACP under conditions of various system and boundary restrictions (open and closed; 50 and 80 C; 0.65 and 0.85 g/cc) show the material to be substantially stable under these simulated isothermal storage conditions from a standpoint of infrared and DTA thermal pattern behavior and chemical analysis of aged residues. Spark sensitivity was 0.25 joules at 5 kv (by LASL type test) and impact sensitivity was about 23 and 14 cm on sandpaper (12A) and steel (12B), respectively.

  17. EU Aid Conditionality in ACP Countries: Explaining Inconsistency in EU Sanctions Practice

    Directory of Open Access Journals (Sweden)

    Karen Del Biondo

    2011-09-01

    Full Text Available The EU is often criticised for using negative conditionality only in poor, strategically less important countries in the ACP region. However, whether and why there is inconsistency within the group of ACP countries has not been properly investigated. Therefore, this article investigates the reasons for the EU’s non-application of Article 96 of the Cotonou Agreement in five countries that can be considered typical cases where negative conditionality is generally imposed, namely countries that experienced flawed elections over the last ten years: Ethiopia, Rwanda, Nigeria, Kenya and Chad. On the one hand, the study confirms previous findings that security interests tend to trump the EU’s efforts to promote democratisation. On the other hand, the article adds that democratisation might not only conflict with the EU’s interests, but also with its objective to promote development and poverty reduction.

  18. Effects of the addition of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) on mechanical properties of luting and lining glass ionomer cement

    Science.gov (United States)

    Heravi, Farzin; Bagheri, Hossein; Rangrazi, Abdolrasoul; Mojtaba Zebarjad, Seyed

    2016-07-01

    Recently, the addition of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) into glass ionomer cements (GICs) has attracted interest due to its remineralization of teeth and its antibacterial effects. However, it should be investigated to ensure that the incorporation of CPP-ACP does not have significant adverse effects on its mechanical properties. The purpose of this study was to evaluate the effects of the addition of CPP-ACP on the mechanical properties of luting and lining GIC. The first step was to synthesize the CPP-ACP. Then the CPP-ACP at concentrations of 1%, 1.56% and 2% of CPP-ACP was added into a luting and lining GIC. GIC without CPP-ACP was used as a control group. The results revealed that the incorporation of CPP-ACP up to 1.56%(w/w) increased the flexural strength (29%), diametral tensile strength (36%) and microhardness (18%), followed by a reduction in these mechanical properties at 2%(w/w) CPP-ACP. The wear rate was significantly decreased (23%) in 1.56%(w/w) concentration of CPP-ACP and it was increased in 2%(w/w). Accordingly, the addition of 1.56%(w/w) CPP-ACP into luting and lining GIC had no adverse effect on the mechanical properties of luting and lining GIC and could be used in clinical practice.

  19. Hyaluronic acid auto-crosslinked polymer (ACP): Reaction monitoring, process investigation and hyaluronidase stability.

    Science.gov (United States)

    Pluda, Stefano; Pavan, Mauro; Galesso, Devis; Guarise, Cristian

    2016-10-04

    Hyaluronic Acid (HA) is a non-sulphated glycosaminoglycan that, despite its high molecular weight, is soluble in water and is not resistant to enzymatic degradation, the latter of which hinders its wider application as a biomedical material. Auto-crosslinked polymer (ACP) gels of HA are fully biocompatible hydrogels that exhibit improved viscoelastic properties and prolonged in vivo residence times compared to the native polymer. Crosslinking is achieved through a base-catalysed reaction consisting of the activation of HA carboxyl groups by 2-chloro-1-methylpyridinium iodide (CMPI) and subsequent nucleophilic acyl substitution by the hydroxyl groups of HA in organic solvent. In this study, a number of ACP hydrogels have been obtained via reactions using varying ratios of CMPI to HA. The crosslinking reaction was monitored by rheological measurements in organic solvents during CMPI addition to the reaction mixture. The ACP intermediates, powders and hydrogels were characterized, helping to elucidate the crosslinking process. A two-step mechanism was proposed to explain the observed trends in viscosity and particle size. Syntheses were carried out by varying the reaction temperature, respectively at 0 °C, 25 °C and 45 °C in N-Methyl-2-Pyrrolidone (NMP), as well as the solvent respectively in NMP, DMSO and DMF at 25 °C. Interestingly, varying these parameters did not substantially affect the degree of crosslinking but likely did influence the intra/inter-molecular crosslinking ratio and, therefore, the viscoelastic properties. A wide range of crosslinking densities was confirmed through ESEM analysis. Finally, a comparative hyaluronidase degradation assay revealed that the ACPs exhibited a higher resistance toward enzymatic cleavage at low elastic modulus compared to other more chemically resistant, crosslinked HAs. These observations demonstrated the importance of crosslinking density of matrix structures on substrate availability. Copyright © 2016 Elsevier

  20. Environment for the simulation of different ACP and error recovery in Distributed Data Bases

    OpenAIRE

    Ruscuni, Sebastián; Bertone, Rodolfo Alfredo

    2001-01-01

    This paper presents an evolution of a simulation environment where situations in which a DDB should maintain data integrity are modeled and implemented. These situations include failures taking place during transactions, and the focus is mainly on the utilization and later comparison of different atomic commit protocols (ACP). The implementation was made on Java due to different aspects such as ease of work, portability, etc. The environment is mainly based on failure recovery of transactions...

  1. ORGANIZATIONAL CONFLICT OF INTEREST AND THE AIR FORCE CONTRACT AUGMENTATION PROGRAM: A PATTERNED APPROACH TO RISK IDENTIFICATION

    Science.gov (United States)

    2016-04-22

    contracting officer reasonably considered OCI in the protested acquisition. Conversely, 75% of Army Air Force Navy Kellog Brown Root (KBR) KBR KBR Fluor...Salem, OR, 2010. http://www.willamette.edu/~smaser/The%20Bid- Protest%20Mechanism.pdf Moore, Nancy Y., Clifford A. Grammich, and Judith D. Mele

  2. 76 FR 16388 - Fees for Reviews of the Rule Enforcement Programs of Contract Markets and Registered Futures...

    Science.gov (United States)

    2011-03-23

    ... (National Futures Association (NFA), a registered futures association, and the contract markets are referred... are collectively referred to herein as SROs, regulated by the Commission. \\1\\ NFA is the only... SROs over the last three years, and ``t'' equals the average annual costs for all SROs. NFA has no...

  3. Contract out

    Energy Technology Data Exchange (ETDEWEB)

    Walker, S. (Independent Editorial and Technical Services, Oxford (United Kingdom))

    1999-05-01

    Mining companies opt to offer all or part of their operations out to contract mainly to reduce risk. Contract mining has been most popular in the Southern Hemisphere over the last 15 years, with some exceptions - contractors were often employed in the UK's opencast coal sector and some US coal operators have made extensive use of contract mining. The article discusses the pros and cons of outsourcing, giving examples of contracted out work in Australia (by Thiess Contractors) the USA (Morrison Knudsen), and the UK (Kie Mining). The author comments that successful contracting can only be achieved where both parties know where they stand and have a good working relationship. 2 photos.

  4. KD-ACP: A Software Framework for Social Computing in Emergency Management

    Directory of Open Access Journals (Sweden)

    Bin Chen

    2015-01-01

    Full Text Available This paper addresses the application of a computational theory and related techniques for studying emergency management in social computing. We propose a novel software framework called KD-ACP. The framework provides a systematic and automatic platform for scientists to study the emergency management problems in three aspects: modelling the society in emergency scenario as the artificial society; investigating the emergency management problems by the repeat computational experiments; parallel execution between artificial society and the actual society managed by the decisions from computational experiments. The software framework is composed of a series of tools. These tools are categorized into three parts corresponding to “A,” “C,” and “P,” respectively. Using H1N1 epidemic in Beijing city as the case study, the modelling and data generating of Beijing city, experiments with settings of H1N1, and intervention measures and parallel execution by situation tool are implemented by KD-ACP. The results output by the software framework shows that the emergency response decisions can be tested to find a more optimal one through the computational experiments. In the end, the advantages of the KD-ACP and the future work are summarized in the conclusion.

  5. 48 CFR 819.7009 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 819.7009... Acquisition Program 819.7009 Contract clauses. The contracting officer shall insert VAAR clause 852.219-10... Veteran-Owned Small Business Set-Aside in solicitations and contracts for acquisitions under this subpart. ...

  6. Anti-caries effect of CPP-ACP in irradiated nasopharyngeal carcinoma patients.

    Science.gov (United States)

    Sim, Christina P C; Wee, Joseph; Xu, Ying; Cheung, Yin-Bun; Soong, Yoke-Lim; Manton, David J

    2015-06-01

    The aim of this study was to determine the effect of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) on caries progression in irradiated nasopharyngeal carcinoma (NPC) patients. Twenty-one males and three females (median age, 50 years) were randomized into two groups before radiotherapy. Subjects had at least eight teeth after oral health clearance. The test group used 0.4 % stannous fluoride gel and a crème containing 10 % CPP-ACP daily; the control group used a similar crème without CPP-ACP and otherwise identical care. Subjects applied the crème three times daily and fluoride gel once daily. Caries status, saliva and plaque parameters were measured pre-radiotherapy, at 2 weeks and 3 months post-radiotherapy. Baseline International Caries Detection and Assessment System (ICDAS) scores were 0-1126 surfaces (93.9 %), 1-28 surfaces (2.3 %), 2-40 surfaces (3.3 %) and 3-6 surfaces (0.5 %) for the control and 0-1186 surfaces (95.6 %), 1-31 surfaces (2.5 %), 2-15 surfaces (1.2 %) and 3-8 surfaces (0.7 %) for the test group. Twenty-two subjects returned at 3 months post-radiotherapy with reduced plaque pH, salivary flow, pH and buffering capacity. Nine test and 8 control subjects developed 32 and 59 new caries lesions, respectively. Test subjects showed lower caries progression than the controls: all surfaces (OR 0.51, 95 % CI 0.17∼1.59), occlusal (OR 0.20, 95 % CI 0.03∼1.29) and smooth surfaces (OR 0.61, 95 % CI 0.16∼2.38). The difference was not statistically significant. Application of CPP-ACP did not significantly reduce caries progression in NPC patients in the first 3 months after radiotherapy as compared to controls. Adjunct use of CPP-ACP with stannous fluoride gel in irradiated NPC patients gave comparable results compared to stannous fluoride gel alone in reducing caries progression.

  7. Intravaginal artificial insemination in bitches using frozen/thawed semen after dilution in powdered coconut water (ACP-106c).

    Science.gov (United States)

    Uchoa, D C; Silva, T F P; Mota Filho, A C; Silva, L D M

    2012-12-01

    The aim of this study was to evaluate powdered coconut water extender (ACP-106c; ACP Serviços Tecnológicos Ltda, ACP Biotecnologia, Fortaleza, Ceará, Brazil) as a diluent for freezing dog semen and the fertility after vaginal insemination of semen frozen therein. Ten ejaculates were collected from five dogs, evaluated fresh, diluted in ACP-106c, 10% egg yolk and 6% glycerol, cooled and frozen. In the first phase of the study, straws with frozen semen were thawed and immediately subjected to the same analysis as the fresh semen and, in addition, to Computer-Assisted Semen Analysis (CASA). In phase 2, 10 bitches that had been subjected to natural breeding during a preceding oestrous cycle were vaginally inseminated with thawed semen that had been re-diluted in ACP-106c. After thawing, a mean of 77% sperm motility was obtained through subjective analysis and 77.3% through CASA. Following artificial insemination, a 60% pregnancy rate was observed, resulting in a 50% parturition rate and a mean litter size of 3.4 (SEM 0.6), with 47.1% males and 52.9% females. ACP-106c can be successfully used for freezing canine semen, and vaginal deposition of such semen yields similar pregnancy rates to those reported in other studies. © 2012 Blackwell Verlag GmbH.

  8. Learning contracts

    Directory of Open Access Journals (Sweden)

    Nena Mijoč

    2006-12-01

    Full Text Available There are four different expressions to describe the method of learning, which increases the efficiency of adult learning. The article explains the translation of »learning contract« into Slovene as a method in adult learning area, which came in use in USA in 1970, also in organizations offering formal education. In the period of lifelong learning, when everyone is supposed to be able to learn efficiently from different sources it is even more important to have the skills to plan our learning. Learning contract develops these competencies and has already become established in organizations, which support learning processes. Learning contract is slowly gaining ground also to the area of formal education. Learning contract is an agreement in writing between two people, where one of them offers advice, the other undertakes the learning process. How do we prepare the agreement, who is responsible for its preparation and execution? Learning contract in writing explains objectives, techniques, strategies and how the learning process will be assessed. At the same time, learning is also limited in time. It is a strong motivational took, since it comprises needs of an individual and is adapted to the interests and learning style of a particular individual. This is especially suitable method for acquiring competencies, for field work and experiential learning at work. Learning contract is very suitable and efficient also for independent academical studies, especially when combined with the method of discussion.

  9. The effect of CPP-ACP-propolis chewing gum on calcium and phosphate ion release on caries-active subjects’ saliva and the formation of Streptococcus mutans biofilm

    Science.gov (United States)

    Hasnamudhia, F.; Bachtiar, E. W.; Sahlan, M.; Soekanto, S. A.

    2017-08-01

    The aim of this study was to analyze the effect of CPP-APP and propolis wax if they are combined in a chewing gum formulation, observed from the calcium and phosphate ion level released by CPP-ACP and the emphasis of Streptococcus mutans mass in the biofilm by propolis wax on caries-active subjects’ saliva. Chewing gum simulation was done in vitro on 25 caries-active subjects’ saliva using five concentrations of chewing gum (0% propolis + 0% CPP-ACP, 0% propolis + CPP-ACP, 2% propolis + CPP-ACP, 4% propolis + CPP-ACP, and 6% propolis + CPP-ACP) and was then tested using an atomic absorption spectrophotometer to analyze calcium ion levels, an ultraviolet-visible spectrophotometer to analyze phosphate ion levels, and a biofilm assay using crystal violet to analyze the decline in biofilm mass. After the chewing simulation, calcium ion levels on saliva+gum eluent increased significantly compared to the saliva control, with the highest calcium level released by CPP-ACP + 2% propolis chewing gum. There was an insignificant phosphate level change between the saliva control and saliva+gum eluent. There was also a significant decline of S. mutans biofilm mass in the saliva+gum eluent, mostly by the CPP-ACP chewing gum and CPP-ACP + 6% propolis. The CPP-ACP-propolis chewing gum simulation generated the largest increase in calcium and phosphate ion level and the largest decline in S. mutans biofilm mass.

  10. 42 CFR 422.641 - Contract determinations.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 3 2010-10-01 2010-10-01 false Contract determinations. 422.641 Section 422.641... (CONTINUED) MEDICARE PROGRAM MEDICARE ADVANTAGE PROGRAM Medicare Contract Determinations and Appeals § 422.641 Contract determinations. This subpart establishes the procedures for making and reviewing the...

  11. Contract Renewal Information - all Contracts

    Data.gov (United States)

    Department of Housing and Urban Development — Multifamily Portfolio datasets (section 8 contracts) - The information has been compiled from multiple data sources within FHA or its contractors. HUD oversees more...

  12. Application of a Dielectric Barrier Discharge Atmospheric Cold Plasma (Dbd-Acp) for Eshcerichia Coli Inactivation in Apple Juice.

    Science.gov (United States)

    Liao, Xinyu; Li, Jiao; Muhammad, Aliyu Idris; Suo, Yuanjie; Chen, Shiguo; Ye, Xingqian; Liu, Donghong; Ding, Tian

    2018-02-01

    Atmospheric cold plasma (ACP) is a promising non-thermal technology in food industry. In this study, a dielectric barrier discharge (DBD)-ACP exhibited strong bactericidal effect on Escherichia coli in apple juice. Under a 30 to 50 W input power, less than 40 s treatment time was required for DBD-ACP to result in 3.98 to 4.34 log CFU/mL reduction of E. coli in apple juice. The inactivation behavior of ACP on E. coli was well described by the Weibull model. During the treatment, the cell membrane of E. coli was damaged severely by active species produced by plasma, such as hydrogen peroxide, ozone and nitrate. In addition, the ACP exposure had slight effect on the °Brix, pH, titratable acidity (TA), color values, total phenolic content, and antioxidant capacity of apple juice. However, higher level of DBD-ACP treatment, 50 W for more than 10 s in this case, resulted in significant change of the pH, TA, color and total phenolic content of apple juice. The results in this study have provided insight in potential use of DBD-ACP as an alternative to thermal processing for fruit juices in food industry. Escherichia coli O157:H7 in apple juice is a potential risk for public health. This study demonstrated that 30 s cold plasma treatment resulted in more than 4 log CFU/mL reduction under 50 W, while the quality attributes of apple juice were not significantly affected. Therefore, cold plasma technology is a promising alternative substitute of traditional thermal processing for juice pasteurization. © 2018 Institute of Food Technologists®.

  13. Protective effect of calcium nanophosphate and CPP-ACP agents on enamel erosion

    Energy Technology Data Exchange (ETDEWEB)

    Carvalho, Fabiola Galbiatti de; Santos, Rogerio Lacerda dos, E-mail: fabigalbi@yahoo.com.br [Universidade Federal de Campina Grande (UFCG), Patos, PB (Brazil). Dept. de Ciencias Biologicas. Div. de Odontologia; Silva Filho, Tiago Joao da; Carlo, Hugo Lemes [Universidade Federal da Paraiba (UFPB), Joao Pessoa, PB (Brazil). Centro de Ciencias da Saude. Dept. de Odontologia Restauradora; Lima, Bruno Alessandro Silva Guedes de [Universidade Federal da Paraiba (UFPB), Joao Pessoa, PB (Brazil). Dept. de Tecnologia Mecanica. Lab. de Solidificacao Rapida

    2013-11-15

    The aim of this study was to assess the effect of different remineralizing agents on enamel microhardness (KHN) and surface topography after an erosive challenge. Forty-eight human enamel specimens (4 X 4 mm) were randomly assigned to 4 groups: control (no treatment), fluoride varnish, calcium nanophosphate paste and casein phosphopeptide-amorphous calcium phosphate paste (CPP-ACP). Both pastes were applied for 5 minutes, and fluoride varnish, for 24 h. Four daily erosive cycles of 5 minutes of immersion in a cola drink and 2 h in artificial saliva were conducted for 5 days. KHN readings were performed at baseline and after 5 days. The percentage of enamel hardness change (%KHN) was obtained after erosion. The surface topography was evaluated by atomic force microscopy (AFM). The data were tested using ANOVA, Tukey's and paired-T tests (p < 0.05). After an erosive challenge, there was no statistically significant difference between the control (96.8 ± 11.4 KHN / 72.4 ± 3.0 %KHN) and the varnish (91.7 ± 14.1 KHN / 73.4 ± 5.5 %KHN) groups. The nanophosphate group showed lower enamel hardness loss (187.2 ± 27.9 /49.0 ± 7.9 %KHN), compared with the CPP-ACP group (141.8 ± 16.5 /60.6 ± 4.0 %KHN), and both were statistically different from the varnish and the control groups. AFM images showed a rough surface for the control and the varnish groups, a non-homogeneous layer with globular irregularities for CPP-ACP, and a thick homogeneous layer for the nanophosphate group. None of the agents provided protection against the development of erosion; however, nanophosphate paste was able to reduce enamel surface softening after the erosive challenge. (author)

  14. Protective effect of calcium nanophosphate and CPP-ACP agents on enamel erosion

    Directory of Open Access Journals (Sweden)

    Fabiola Galbiatti de Carvalho

    2013-12-01

    Full Text Available The aim of this study was to assess the effect of different remineralizing agents on enamel microhardness (KHN and surface topography after an erosive challenge. Forty-eight human enamel specimens (4 × 4 mm were randomly assigned to 4 groups: control (no treatment, fluoride varnish, calcium nanophosphate paste and casein phosphopeptide-amorphous calcium phosphate paste (CPP-ACP. Both pastes were applied for 5 minutes, and fluoride varnish, for 24 h. Four daily erosive cycles of 5 minutes of immersion in a cola drink and 2 h in artificial saliva were conducted for 5 days. KHN readings were performed at baseline and after 5 days. The percentage of enamel hardness change (%KHN was obtained after erosion. The surface topography was evaluated by atomic force microscopy (AFM. The data were tested using ANOVA, Tukey's and paired-T tests (p < 0.05. After an erosive challenge, there was no statistically significant difference between the control (96.8 ± 11.4 KHN / 72.4 ± 3.0 %KHN and the varnish (91.7 ± 14.1 KHN / 73.4 ± 5.5 %KHN groups. The nanophosphate group showed lower enamel hardness loss (187.2 ± 27.9 / 49.0 ± 7.9 %KHN, compared with the CPP-ACP group (141.8 ± 16.5 / 60.6 ± 4.0 %KHN, and both were statistically different from the varnish and the control groups. AFM images showed a rough surface for the control and the varnish groups, a non-homogeneous layer with globular irregularities for CPP-ACP, and a thick homogeneous layer for the nanophosphate group. None of the agents provided protection against the development of erosion; however, nanophosphate paste was able to reduce enamel surface softening after the erosive challenge

  15. 48 CFR 619.808 - Contract negotiation.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Contract negotiation. 619.808 Section 619.808 Federal Acquisition Regulations System DEPARTMENT OF STATE SOCIOECONOMIC PROGRAMS... Contract negotiation. ...

  16. Utility Energy Services Contracts: Enabling Documents

    Energy Technology Data Exchange (ETDEWEB)

    Thomas, Karen; Vasquez, Deb

    2017-01-01

    The Federal Energy Management Program's 'Utility Energy Service Contracts: Enabling Documents' provide legislative information and materials that clarify the authority for federal agencies to enter into utility energy service contracts, or UESCs.

  17. Contract Training: Progress and Policy Issues.

    Science.gov (United States)

    Deegan, William L.; Drisko, Ronald

    1985-01-01

    Provides results of a national survey of community college contract training programs, including data on the extent of the colleges' involvement, centralization/decentralization of contract training, problems and benefits, and future trends. Discusses future policy trends. (HB)

  18. Contract Management: New Pupil Transportation Option.

    Science.gov (United States)

    Couzins, Jerome P.

    1984-01-01

    Using contract management services for their student transportation programs, school districts can maintain local control and accountability, limit administrative costs, improve management continuity, and reduce staff overhead. Competition for contract renewal stimulates service improvement. (MCG)

  19. Afghan National Security Forces: Despite Reported Successes, Concerns Remain about Literacy Program Results, Contract Oversight, Transition, and Sustainment

    Science.gov (United States)

    2014-01-01

    Special Inspector General for Afghanistan Reconstruction (SIGAR), 1550 Crystal Drive, Suite 900 (Attn: Ms. Gabriele Tonsil ), Arlington, VA 22202...ACKNOWLEDGMENTS Gabriele Tonsil , Senior Audit Manager Clifton Spruill, Analyst-in-Charge Vicki McClure, Senior Program Analyst Donnalee Scharschmidt, Program

  20. Acyl-ACP thioesterases from Camelina sativa: cloning, enzymatic characterization and implication in seed oil fatty acid composition.

    Science.gov (United States)

    Rodríguez-Rodríguez, Manuel Fernando; Salas, Joaquín J; Garcés, Rafael; Martínez-Force, Enrique

    2014-11-01

    Acyl-acyl carrier protein (ACP) thioesterases are intraplastidial enzymes that terminate de novo fatty acid biosynthesis in the plastids of higher plants by hydrolyzing the thioester bond between ACP and the fatty acid synthesized. Free fatty acids are then esterified with coenzyme A prior to being incorporated into the glycerolipids synthesized through the eukaryotic pathway. Acyl-ACP thioesterases belong to the TE14 family of thioester-active enzymes and can be classified as FatAs and FatBs, which differ in their amino acid sequence and substrate specificity. Here, the FatA and FatB thioesterases from Camelina sativa seeds, a crop of interest in plant biotechnology, were cloned, sequenced and characterized. The mature proteins encoded by these genes were characterized biochemically after they were heterologously expressed in Escherichia coli and purified. C. sativa contained three different alleles of both the FatA and FatB genes. These genes were expressed most strongly in expanding tissues in which lipids are very actively synthesized, such as developing seed endosperm. The CsFatA enzyme displayed high catalytic efficiency on oleoyl-ACP and CsFatB acted efficiently on palmitoyl-ACP. The contribution of these two enzymes to the synthesis of C. sativa oil was discussed in the light of these results. Copyright © 2014 Elsevier Ltd. All rights reserved.

  1. Agile Contracts

    DEFF Research Database (Denmark)

    Pries-Heje, Jan; Pries-Heje, Lene

    2014-01-01

    with “endless” re-negotiation of the requirements; you need a more flexible way to develop IS. A new way of coping with many changes is to use an agile development approach and a fixed budget and resources contract. This paper presents an example case. We analyse the case and design a guideline for how...

  2. Protective effect on enamel demineralization of a CPP-ACP paste: an AFM in vitro study.

    Science.gov (United States)

    Poggio, Claudio; Lombardini, Marco; Dagna, Alberto; Chiesa, Marco; Bianchi, Stefano

    2009-12-01

    The aim of the present in vitro study was the evaluation of a CPP-ACP paste (Tooth Mousse) on preventing dental erosion produced by a soft drink (Coca Cola), using Atomic Force Microscopy (AFM). Thirty extracted human central incisors free of caries were selected and divided in a treatment and a control half. The treatment halves were divided in three groups-group 1: demineralization with soft drink (4 intervals of 2 min); group 2: demineralization with soft drink (4 intervals of 2 min) plus Tooth Mousse; group 3: intact enamel plus Tooth Mousse. In groups 2 and 3 Tooth Mousse was applied for 3 min at 0, 8, 24 and 36 h. The surface of each specimen was imaged by AFM and R(rms) values were registered. Among treatment specimens of groups 1 and 2, a statistically significant difference (Ppaste had a protective effect on enamel demineralization. In group 3 no statistically significant difference was registered between exposed and not exposed halves of the specimens. The use of a CPP-ACP paste had a protective effect on enamel demineralization in an in vitro model.

  3. Evaluation of the remineralization capacity of CPP-ACP containing fluoride varnish by different quantitative methods

    Directory of Open Access Journals (Sweden)

    Selcuk SAVAS

    Full Text Available ABSTRACT Objective The aim of this study was to evaluate the efficacy of CPP-ACP containing fluoride varnish for remineralizing white spot lesions (WSLs with four different quantitative methods. Material and Methods Four windows (3x3 mm were created on the enamel surfaces of bovine incisor teeth. A control window was covered with nail varnish, and WSLs were created on the other windows (after demineralization, first week and fourth week in acidified gel system. The test material (MI Varnish was applied on the demineralized areas, and the treated enamel samples were stored in artificial saliva. At the fourth week, the enamel surfaces were tested by surface microhardness (SMH, quantitative light-induced fluorescence-digital (QLF-D, energy-dispersive spectroscopy (EDS and laser fluorescence (LF pen. The data were statistically analyzed (α=0.05. Results While the LF pen measurements showed significant differences at baseline, after demineralization, and after the one-week remineralization period (p0.05. With regards to the SMH and QLF-D analyses, statistically significant differences were found among all the phases (p<0.05. After the 1- and 4-week treatment periods, the calcium (Ca and phosphate (P concentrations and Ca/P ratio were higher compared to those of the demineralization surfaces (p<0.05. Conclusion CPP-ACP containing fluoride varnish provides remineralization of WSLs after a single application and seems suitable for clinical use.

  4. 77 FR 74351 - Fees for Reviews of the Rule Enforcement Programs of Designated Contract Markets and Registered...

    Science.gov (United States)

    2012-12-14

    ... oversight program costs, they are in line with the pro rata percentage for that SRO of United States... recent three years, plus a pro rata share (based on average trading volume for the most recent three...

  5. Russian Contract Procurement Document

    Energy Technology Data Exchange (ETDEWEB)

    Tobin, J G

    2010-03-29

    This contract supports the enhancement of physical protection or nuclear material control and accounting systems at institutes or enterprises of the newly independent states under the material protection control and accounting (MPC&A) program. The contract is entered into pursuant to the MPC&A Program, a gratuitous technical assistance program, in accordance with the bilateral Agreements between the Russian Federation and the United States of America concerning the Safe and Secure Transportation, Storage and Destruction of Weapons and the Prevention of Weapons Proliferation of June 1992, as extended and amended by Protocol signed of June 1999, Agreement between the Government of the Russian Federation regarding Cooperation in the Area of Nuclear Materials Physical Protection, Control and Accounting of October 1999 and the Russian Federation law of May 1999 on the taxation exemption of gratuitous technical assistance with Russian Federation under registration No.DOE001000.

  6. 42 CFR 434.10 - Contracts with fiscal agents.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 4 2010-10-01 2010-10-01 false Contracts with fiscal agents. 434.10 Section 434.10... (CONTINUED) MEDICAL ASSISTANCE PROGRAMS CONTRACTS Contracts with Fiscal Agents and Private Nonmedical Institutions § 434.10 Contracts with fiscal agents. Contracts with fiscal agents must— (a) Meet the...

  7. Testing geopressured geothermal reservoirs in existing wells. Wells of Opportunity Program final contract report, 1980-1981

    Energy Technology Data Exchange (ETDEWEB)

    1982-01-01

    The geopressured-geothermal candidates for the Wells of Opportunity program were located by the screening of published information on oil industry activity and through direct contact with the oil and gas operators. This process resulted in the recommendation to the DOE of 33 candidate wells for the program. Seven of the 33 recommended wells were accepted for testing. Of these seven wells, six were actually tested. The first well, the No. 1 Kennedy, was acquired but not tested. The seventh well, the No. 1 Godchaux, was abandoned due to mechanical problems during re-entry. The well search activities, which culminated in the acceptance by the DOE of 7 recommended wells, were substantial. A total of 90,270 well reports were reviewed, leading to 1990 wells selected for thorough geological analysis. All of the reservoirs tested in this program have been restricted by one or more faults or permeability barriers. A comprehensive discussion of test results is presented.

  8. Contract theory and EU Contract Law

    NARCIS (Netherlands)

    Hesselink, M.W.; Twigg-Flesner, C.

    2016-01-01

    This paper explores the relationship between contract theory and European contract law. In particular, it confronts the leading contract law theories with the main characteristics of EU contract law. The conclusion is that the two do not match well. In particular, monist normative contract theories

  9. Unit Testing Using Design by Contract and Equivalence Partitions, Extreme Programming and Agile Processes in Software Engineering

    DEFF Research Database (Denmark)

    Madsen, Per

    2003-01-01

    Extreme Programming [1] and in particular the idea of Unit Testing can improve the quality of the testing process. But still programmers need to do a lot of tiresome manual work writing test cases. If the programmers could get some automatic tool support enforcing the quality of test cases then t...... then the overall quality of the software would improve significantly.......Extreme Programming [1] and in particular the idea of Unit Testing can improve the quality of the testing process. But still programmers need to do a lot of tiresome manual work writing test cases. If the programmers could get some automatic tool support enforcing the quality of test cases...

  10. Influence of biofilm formation on the mechanical properties of enamel after treatment with CPP-ACP crème

    OpenAIRE

    Patrícia Regina Almeida de Oliveira; Thereza Christina Lopes Coutinho; Maristela Barbosa Portela; Viviane Cancio Andrade de Paula; Mônica Almeida Tostes

    2017-01-01

    Abstract: The study aimed to investigate the effects of bacterial biofilms on changes in the surface microhardness of enamel treated with casein phosphopeptide—amorphous calcium phosphate (CPP-ACP) with and without fluoride. Human enamel blocks with incipient caries-like lesions were divided into four groups of 13: G1: Saliva (Control); G2: fluoride dentifrice (Crest™, 1100 ppm as NaF); G3: CPP-ACP (MI Paste; Recaldent™); and G4: CPP-ACPF (MI Paste Plus; Recaldent™ 900 ppm as NaF). The specim...

  11. A STUDY OF CONTINUING EDUCATION NEEDS OF SELECTED PROFESSIONAL GROUPS AND UNIVERSITY EXTENSION CONTRACT PROGRAMS IN WYOMING.

    Science.gov (United States)

    NICHOLAS, ROBERT A.

    THIS STUDY AIMED TO DEVELOP PRINCIPLES FOR A MODEL PROGRAM OF CONTINUING EDUCATION FOR THE PROFESSIONS AT THE UNIVERSITY OF WYOMING. THE AUTHOR REVIEWED THE LITERATURE ON THE GROWTH OF THE PROFESSIONS AND ON CONTINUING EDUCATION IN THE PROFESSIONS GENERALLY, WITH SPECIAL REFERENCE TO ARCHITECTURE, DENTISTRY, LAW, MEDICINE, AND PHARMACY. FROM THIS…

  12. 48 CFR 923.103 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 923.103... Contract clauses. Insert the clause at 952.223-78, Sustainable Acquisition Program, or its Alternate I, in all contracts under which the contractor operates Government-owned facilities or Government-owned...

  13. THE EUROPEAN UNION AND PARTNERSHIPS WITH DEVELOPING COUNTRIES – THE CASE OF ACP REGION

    Directory of Open Access Journals (Sweden)

    Viera Dobošová

    2007-04-01

    Full Text Available The EU has developed a wide cooperation network with developing countries based on trade, cooperation, aid and other aspects. These bilateral and regional agreements serve various and specific interests of the EU and the concerned countries and cover not only trade, but also other broad issues. However, above those remain the main goals of the EU in the area of the common commercial policy, development policy and external relations policy. The trend of regional integration and regional trade agreements proliferation has influenced these relations as well. The article will examine this trend in the network of EU trade agreements with developing countries, specifically with the African, Caribbean and Pacific region. Some critical issues of the EU – ACP cooperation will be identified.

  14. Entamoeba histolytica: cloning, expression and evaluation of the efficacy of a recombinant amebiasis cysteine proteinase gene (ACP1) antigen in minipig.

    Science.gov (United States)

    He, Guang-Zhi

    2012-02-01

    The amebiasis cysteine proteinase gene (ACP1) encoding an antigen from Entamoeba histolytica, as well as the recombinant ACP1, obtained by cloning and expression of the ACP1 gene in heterologous host Escherichia coli BL-21 (DE3), were used to evaluate their ability to induce immune protective responses in minipig against challenge infection in a minipig -E. histolytica model. There was a 64.52% reduction (P<0.001) in the group of recovery of challenged E. histolytica compared with that in the control group. Specific anti-ACP1 antibodies from immune protected minipig had significantly higher levels of immunoglobulin G (IgG) (P<0.001). Our data indicate recombinant ACP1 may be a potential target as a vaccine antigen. Copyright © 2011 Elsevier Inc. All rights reserved.

  15. Retractable Contracts

    Directory of Open Access Journals (Sweden)

    Franco Barbanera

    2016-02-01

    Full Text Available In calculi for modelling communication protocols, internal and external choices play dual roles. Two external choices can be viewed naturally as dual too, as they represent an agreement between the communicating parties. If the interaction fails, the past agreements are good candidates as points where to roll back, in order to take a different agreement. We propose a variant of contracts with synchronous rollbacks to agreement points in case of deadlock. The new calculus is equipped with a compliance relation which is shown to be decidable.

  16. Oriented and Ordered Biomimetic Remineralization of the Surface of Demineralized Dental Enamel Using HAP@ACP Nanoparticles Guided by Glycine

    Science.gov (United States)

    Wang, Haorong; Xiao, Zuohui; Yang, Jie; Lu, Danyang; Kishen, Anil; Li, Yanqiu; Chen, Zhen; Que, Kehua; Zhang, Qian; Deng, Xuliang; Yang, Xiaoping; Cai, Qing; Chen, Ning; Cong, Changhong; Guan, Binbin; Li, Ting; Zhang, Xu

    2017-01-01

    Achieving oriented and ordered remineralization on the surface of demineralized dental enamel, thereby restoring the satisfactory mechanical properties approaching those of sound enamel, is still a challenge for dentists. To mimic the natural biomineralization approach for enamel remineralization, the biological process of enamel development proteins, such as amelogenin, was simulated in this study. In this work, carboxymethyl chitosan (CMC) conjugated with alendronate (ALN) was applied to stabilize amorphous calcium phosphate (ACP) to form CMC/ACP nanoparticles. Sodium hypochlorite (NaClO) functioned as the protease which decompose amelogenin in vivo to degrade the CMC-ALN matrix and generate HAP@ACP core-shell nanoparticles. Finally, when guided by 10 mM glycine (Gly), HAP@ACP nanoparticles can arrange orderly and subsequently transform from an amorphous phase to well-ordered rod-like apatite crystals to achieve oriented and ordered biomimetic remineralization on acid-etched enamel surfaces. This biomimetic remineralization process is achieved through the oriented attachment (OA) of nanoparticles based on non-classical crystallization theory. These results indicate that finding and developing analogues of natural proteins such as amelogenin involved in the biomineralization by natural macromolecular polymers and imitating the process of biomineralization would be an effective strategy for enamel remineralization. Furthermore, this method represents a promising method for the management of early caries in minimal invasive dentistry (MID).

  17. Oriented and Ordered Biomimetic Remineralization of the Surface of Demineralized Dental Enamel Using HAP@ACP Nanoparticles Guided by Glycine

    Science.gov (United States)

    Wang, Haorong; Xiao, Zuohui; Yang, Jie; Lu, Danyang; Kishen, Anil; Li, Yanqiu; Chen, Zhen; Que, Kehua; Zhang, Qian; Deng, Xuliang; Yang, Xiaoping; Cai, Qing; Chen, Ning; Cong, Changhong; Guan, Binbin; Li, Ting; Zhang, Xu

    2017-01-01

    Achieving oriented and ordered remineralization on the surface of demineralized dental enamel, thereby restoring the satisfactory mechanical properties approaching those of sound enamel, is still a challenge for dentists. To mimic the natural biomineralization approach for enamel remineralization, the biological process of enamel development proteins, such as amelogenin, was simulated in this study. In this work, carboxymethyl chitosan (CMC) conjugated with alendronate (ALN) was applied to stabilize amorphous calcium phosphate (ACP) to form CMC/ACP nanoparticles. Sodium hypochlorite (NaClO) functioned as the protease which decompose amelogenin in vivo to degrade the CMC-ALN matrix and generate HAP@ACP core-shell nanoparticles. Finally, when guided by 10 mM glycine (Gly), HAP@ACP nanoparticles can arrange orderly and subsequently transform from an amorphous phase to well-ordered rod-like apatite crystals to achieve oriented and ordered biomimetic remineralization on acid-etched enamel surfaces. This biomimetic remineralization process is achieved through the oriented attachment (OA) of nanoparticles based on non-classical crystallization theory. These results indicate that finding and developing analogues of natural proteins such as amelogenin involved in the biomineralization by natural macromolecular polymers and imitating the process of biomineralization would be an effective strategy for enamel remineralization. Furthermore, this method represents a promising method for the management of early caries in minimal invasive dentistry (MID). PMID:28079165

  18. Effect of atmospheric cold plasma (ACP) with its extended storage on the inactivation of Escherichia coli inoculated on tomato.

    Science.gov (United States)

    Prasad, Priyanka; Mehta, Deepak; Bansal, Vasudha; Sangwan, Rajender S

    2017-12-01

    The study investigated the efficacy of atmospheric cold plasma (ACP) treatment on inactivation of E. coli load during extended storage period of 48h at both the temperatures of refrigeration (4°C) as well as room (25°C). The tomato samples were spot inoculated with E. coli and exposed to ACP at 15 and 60kV for 5, 10, 15, and 30min followed by their storage at 4°C and 25°C. The highest log reduction of 6logCFUmL -1 was achieved in population of E. coli after 15min of ACP treatment at 60kV, which was sustained up to storage duration of 48h at both the temperatures. Furthermore, significant reduction in E. coli was found at plasma treatment of 60kV in comparison to 15kV. The inactivation of E. coli was significantly (pcoli. In addition, investigation of E. coli exposed tomato surface was done using scanning electron microscopy that clearly showed the breakdown of cell cover of E. coli as a consequence of ACP. The study predicts the promising potential of the technique in sanitization of vegetables that are eaten raw like tomato. Copyright © 2017 Elsevier Ltd. All rights reserved.

  19. Structure of the human beta-ketoacyl [ACP] synthase from the mitochondrial type II fatty acid synthase

    DEFF Research Database (Denmark)

    Christensen, Caspar Elo; Kragelund, Birthe B; von Wettstein-Knowles, Penny

    2007-01-01

    activities encoded by discrete genes. The beta-ketoacyl [ACP] synthase (KAS) moiety of the mitochondrial FAS (mtKAS) is targeted by the antibiotic cerulenin and possibly by the other antibiotics inhibiting prokaryotic KASes: thiolactomycin, platensimycin, and the alpha-methylene butyrolactone, C75. The high...

  20. Data report of BWR post-CHF tests. Transient core thermal-hydraulic test program. Contract research

    Energy Technology Data Exchange (ETDEWEB)

    Iguchi, Tadashi; Itoh, Hideo; Kiuchi, Toshio; Watanabe, Hironori; Kimura, Mamoru; Anoda, Yoshinari [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    2001-03-01

    JAERI has been performing transient core thermal-hydraulic test program. In the program, authors performed BWR/ABWR DBE simulation tests with a test facility, which can simulate BWR/ABWR transients. The test facility has a 4 x 4 bundle core simulator with 15-rod heaters and one non-heated rod. Through the tests, authors quantified the thermal safety margin for core cooling. In order to quantify the thermal safety margin, authors collected experimental data on post-CHF. The data are essential for the evaluation of clad temperature transient when core heat-up occurs during DBEs. In comparison with previous post-CHF tests, present experiments were performed in much wider experimental condition, covering high clad temperature, low to high pressure and low to high mass flux. Further, data at wider elevation (lower to higher elevation of core) were obtained in the present experiments, which make possible to discuss the effect of axial position on thermal-hydraulics, while previous works usually discuss the thermal-hydraulics at the position where the first heat-up occurs. This data report describes test procedure, test condition and major experimental data of post-CHF tests. (author)

  1. Structure of human Fe-S assembly subcomplex reveals unexpected cysteine desulfurase architecture and acyl-ACP-ISD11 interactions.

    Science.gov (United States)

    Cory, Seth A; Van Vranken, Jonathan G; Brignole, Edward J; Patra, Shachin; Winge, Dennis R; Drennan, Catherine L; Rutter, Jared; Barondeau, David P

    2017-07-03

    In eukaryotes, sulfur is mobilized for incorporation into multiple biosynthetic pathways by a cysteine desulfurase complex that consists of a catalytic subunit (NFS1), LYR protein (ISD11), and acyl carrier protein (ACP). This NFS1-ISD11-ACP (SDA) complex forms the core of the iron-sulfur (Fe-S) assembly complex and associates with assembly proteins ISCU2, frataxin (FXN), and ferredoxin to synthesize Fe-S clusters. Here we present crystallographic and electron microscopic structures of the SDA complex coupled to enzyme kinetic and cell-based studies to provide structure-function properties of a mitochondrial cysteine desulfurase. Unlike prokaryotic cysteine desulfurases, the SDA structure adopts an unexpected architecture in which a pair of ISD11 subunits form the dimeric core of the SDA complex, which clarifies the critical role of ISD11 in eukaryotic assemblies. The different quaternary structure results in an incompletely formed substrate channel and solvent-exposed pyridoxal 5'-phosphate cofactor and provides a rationale for the allosteric activator function of FXN in eukaryotic systems. The structure also reveals the 4'-phosphopantetheine-conjugated acyl-group of ACP occupies the hydrophobic core of ISD11, explaining the basis of ACP stabilization. The unexpected architecture for the SDA complex provides a framework for understanding interactions with acceptor proteins for sulfur-containing biosynthetic pathways, elucidating mechanistic details of eukaryotic Fe-S cluster biosynthesis, and clarifying how defects in Fe-S cluster assembly lead to diseases such as Friedreich's ataxia. Moreover, our results support a lock-and-key model in which LYR proteins associate with acyl-ACP as a mechanism for fatty acid biosynthesis to coordinate the expression, Fe-S cofactor maturation, and activity of the respiratory complexes.

  2. An in vitro study on the retentive strength of orthodontic bands cemented with CPP-ACP-containing GIC

    Science.gov (United States)

    Heravi, Farzin; Bagheri, Hossein; Rangrazi, Abdolrasoul; Mojtaba Zebarjad, Seyed

    2016-12-01

    Caries and white spot lesions around orthodontic bands are well known occurrences in fixed orthodontic treatment. There are several methods to overcome these problems. One of these includes modification of the band cement with remineralizing agents such as casein phosphopeptide-amorphous calcium phosphate (CPP-ACP). However, it should be evaluated that the cement modification has no significant negative effects on the retentive strength of the cemented orthodontic bands. In a continuation of our previous studies on the effects of the addition of CPP-ACP on the mechanical properties of luting and lining glass ionomer cement (GIC), this study aimed to investigate the retentive strength of orthodontic bands cemented with CPP-ACP containing GIC. Sixty extracted human pre molars teeth were embedded in acrylic resin and randomly divided into two groups of 30 specimens. In group 1, bands were cemented to the tooth with a GIC. In group 2, CPP-ACP (1.56% w/w) was added to the GIC before cementation. The retentive strength of each groups was determined with a universal testing machine. Further, the amount of cement remaining on the tooth surface was evaluated under a stereomicroscope, and the adhesive remnant index (ARI) score was determined. Results of this study showed that there were no significant differences between the groups in retentive strength and ARI score. In conclusion, modification of GIC with 1.56% w/w CPP-ACP had no negative effects on the retentive strength of the bands so can be used during fixed orthodontic treatment.

  3. Microleakage of Three Types of Glass Ionomer Cement Restorations: Effect of CPP-ACP Paste Tooth Pretreatment.

    Science.gov (United States)

    Doozandeh, Maryam; Shafiei, Fereshteh; Alavi, Mostafa

    2015-09-01

    Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) increases the mineral content of tooth structure. This may enhance the chemical bonding of glass ionomer cements (GIC) and marginal sealing of their restorations. The aim of this study was to evaluate the effect of CPP-ACP paste pretreatment on the microleakage of three types of GIC. In this study, 72 Class V cavities were prepared on the buccal and lingual surfaces of molars with occlusal margins in enamel and gingival margins in root. The cavities were divided into 6 groups. Cavities in group 1 and 2 were restored with Fuji II, group 3 and 4 with Fuji II LC, and group 5 and 6 with Ketac N100 with respect to the manufacturers' instructions. In groups 2, 4 and 6, CPP-ACP containing paste (MI paste) was placed into the cavities for 3 minutes before being filled with GIC. The teeth were thermocycled, stained with dye, sectioned, and scored for microleakage under stereomicroscope. Kruskall-Wallis and Chi-Square tests were used to analyze the data. There were no statistically significant differences between the control and the CPP-ACP pretreatment groups in enamel and dentin margins. In pairwise comparisons, there were no significant differences between the control and the experimental groups in enamel margin, and in dentin margins of G1 and 2, G5 and 6; however, a significant differences was detected in dentin margins between G3 and 4 (p= 0.041). CPP-ACP paste pretreatment did not affect the microleakage of Fuji II and Ketac N100 in enamel or dentin, but decreased the microleakage in dentine margins of Fuji II LC when cavity conditioner was applied before surface treatment.

  4. Comparative Effects of Traditional- versus Contract Activity Packaged- versus Programmed Learning-Sequenced versus Tactual-Instructional Presentations of Course Content on the Achievement and Attitudes of Undergraduate Students in a Private Metropolitan College

    Science.gov (United States)

    Egal, Sylvia

    2009-01-01

    This research was conducted to determine the effects of traditional instruction versus Contract Activity Packaged (CAP) versus Programmed Sequenced Learning (PLS) versus Tactual Resources (TR) on the achievement and attitudes of 32 second-year undergraduate teacher education majors enrolled in two classes of a required child-study course at a…

  5. Biomimetic remineralization of demineralized dentine using scaffold of CMC/ACP nanocomplexes in an in vitro tooth model of deep caries.

    Directory of Open Access Journals (Sweden)

    Zhen Chen

    Full Text Available Currently, it is still a tough task for dentists to remineralize dentine in deep caries. The aim of this study was to remineralize demineralized dentine in a tooth model of deep caries using nanocomplexes of carboxymethyl chitosan/amorphous calcium phosphate (CMC/ACP based on mimicking the stabilizing effect of dentine matrix protein 1 (DMP1 on ACP in the biomineralization of dentine. The experimental results indicate that CMC can stabilize ACP to form nanocomplexes of CMC/ACP, which is able to be processed into scaffolds by lyophilization. In the single-layer collagen model, ACP nanoparticles are released from scaffolds of CMC/ACP nanocomplexes dissolved and then infiltrate into collagen fibrils via the gap zones (40 nm to accomplish intrafibrillar mineralization of collagen. With this method, the completely demineralized dentine was partially remineralized in the tooth mode. This is a bottom-up remineralizing strategy based on non-classical crystallization theory. Since nanocomplexes of CMC/ACP show a promising effect of remineralization on demineralized dentine via biomimetic strategy, thereby preserving dentinal tissue to the maximum extent possible, it would be a potential indirect pulp capping (IPC material for the management of deep caries during vital pulp therapy based on the concept of minimally invasive dentistry (MID.

  6. Biomimetic Remineralization of Demineralized Dentine Using Scaffold of CMC/ACP Nanocomplexes in an In Vitro Tooth Model of Deep Caries

    Science.gov (United States)

    Chen, Zhen; Cao, Shansong; Wang, Haorong; Li, Yanqiu; Kishen, Anil; Deng, Xuliang; Yang, Xiaoping; Wang, Yinghui; Cong, Changhong; Wang, Huajun; Zhang, Xu

    2015-01-01

    Currently, it is still a tough task for dentists to remineralize dentine in deep caries. The aim of this study was to remineralize demineralized dentine in a tooth model of deep caries using nanocomplexes of carboxymethyl chitosan/amorphous calcium phosphate (CMC/ACP) based on mimicking the stabilizing effect of dentine matrix protein 1 (DMP1) on ACP in the biomineralization of dentine. The experimental results indicate that CMC can stabilize ACP to form nanocomplexes of CMC/ACP, which is able to be processed into scaffolds by lyophilization. In the single-layer collagen model, ACP nanoparticles are released from scaffolds of CMC/ACP nanocomplexes dissolved and then infiltrate into collagen fibrils via the gap zones (40 nm) to accomplish intrafibrillar mineralization of collagen. With this method, the completely demineralized dentine was partially remineralized in the tooth mode. This is a bottom-up remineralizing strategy based on non-classical crystallization theory. Since nanocomplexes of CMC/ACP show a promising effect of remineralization on demineralized dentine via biomimetic strategy, thereby preserving dentinal tissue to the maximum extent possible, it would be a potential indirect pulp capping (IPC) material for the management of deep caries during vital pulp therapy based on the concept of minimally invasive dentistry (MID). PMID:25587986

  7. Banana splits and policy challenges: The ACP Caribbean and the fragmentation of interest coalitions

    Directory of Open Access Journals (Sweden)

    Peter Clegg

    2005-10-01

    Full Text Available The article considers the changes that have taken  place within the political economy of international  trade over the last decade. The work begins by  assessing briefly the dynamics of the last successful trade negotiations undertaken by the ACP Caribbean – the agreement on a single European  banana market in 1993. Since then, however, the  international political and economic climate has  dramatically changed. The article evaluates recent  developments, which have highlighted attention  on the political acceptability of trade discrimination, particularly within the context of the General  Agreement on Tariffs and Trade and the World Trade Organisation. In addition, there is an analysis of the reform process undertaken by the European Union, both in terms of its membership and  policy agenda, which has seriously impacted on  Caribbean economic interests. The article establishes that the actors representing the Caribbean  were extremely successful in constructing strategic coalitions to defend their trading interests in  the early 1990s, but the region must now appreciate that the international environment has changed  so dramatically that former negotiating strategies  are no longer appropriate. An awareness of the  changed negotiating environment on the part of  the Caribbean is vitally important if ongoing  international trade negotiations are to be completed to the region’s satisfaction. Resumen: Batallas bananeras y desafíos políticos:  El grupo ACP del Caribe y la fragmentación de las coaliciones de interésEste trabajo considera los cambios ocurridos en la  economía política del comercio internacional  durante la última década. El artículo comienza  con una breve evaluación de la dinámica de las  últimas negociaciones comerciales satisfactorias  del grupo ACP del Caribe: el acuerdo sobre un  mercado único bananero europeo en 1993. Desde  entonces, sin embargo, el clima político y

  8. 48 CFR 26.404 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Contract clause. 26.404 Section 26.404 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SOCIOECONOMIC PROGRAMS OTHER SOCIOECONOMIC PROGRAMS Food Donations to Nonprofit Organizations 26.404 Contract clause. Insert the clause at 52.226-6, Promoting Excess...

  9. 48 CFR 2919.812 - Contract administration.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Contract administration. 2919.812 Section 2919.812 Federal Acquisition Regulations System DEPARTMENT OF LABOR SOCIOECONOMIC PROGRAMS SMALL BUSINESS AND SMALL DISADVANTAGED BUSINESS CONCERNS Contracting with the Small Business Administration (The 8(a) Program) 2919.812...

  10. Performance Contracts -- Success or Failure. Contract Learning Projects, Grand Rapids Public Schools, 1970-72.

    Science.gov (United States)

    Webster, Joan M.

    This report evaluates the Grand Rapids Public School (GRPS) experience with performance contracting. The report describes the first two years of the GRPS performance contracting experience, assesses the accomplishments of those two years, and describes the third year (1972-73) program. The author concludes that the contracts were successful and…

  11. An Analysis of Communication Between Program Managers and Contracting Officers and Its Effect on the Performance of the Defense Acquisition System

    Science.gov (United States)

    2015-09-01

    5 D. METHODOLOGY ...Department of Defense instruction ERP enterprise resource planning FAR Federal Acquisition Regulation FFP firm fixed price FPDS-NG...rejection. xix 2. Contract Type – Interviews revealed several cases where an appropriate contract type was bilaterally selected between the PM

  12. Final Report DOE Supported Activities through the Utility/DOE Matching Grant Program Contract Number DE FG02-95NE38111 For the Period 30 September 1995 through 30 September 2002 Extended until 30 March 2003

    Energy Technology Data Exchange (ETDEWEB)

    Stubbins, James F.

    2003-08-15

    This report covers activities in the Univesity of Illinois Department of Nulcear, Plasma and Radiological Engineering Matching Grant Program for the period form 30 September 1995 to 30 March 2003. The funds for this program include industrial partner funds which were matched, or nearly matched by DOE-NE. The industrial partner was Commonwealth Edison, which changed its corporate structure and name to Exelon during the course of the contract. The funds from the contract were used to support nuclear engineering educational needs, including undergraduate and graduate students support, purchase of laboratory equipment, support for seminar speakers and conferences, and support for new faculty members. The funds were instrumental in maintaining a first quality nuclear engineering educational program at the University of Illinois.

  13. The European Union’s and Poland’s trade relations with the African, Caribbean and Pacific group of states (ACP in the agri-food products in the years 2000-2009

    Directory of Open Access Journals (Sweden)

    Katarzyna Kita

    2012-01-01

    Full Text Available The aim of the paper is to examine key trends in the European Union’s trade policy towards the African, Caribbean and Pacific group of states (ACP, as well as to identify main changes in the commodity structure of the European (and Polish agri-food trade. The results showed that for the ACP countries, the European market is perceived as a source of food industry while the EU (including Poland imports from ACP region coffee, tea and cocoa. This confirms a certain specialization of production and trade in ACP countries. Both the European Union and Poland, are net importers of agri- food products from the ACP region.

  14. Contracting as a Science

    Science.gov (United States)

    2012-04-30

    neoclassical theory to be classified as financial, physical, legal, human, organizational, informational, and relational. Each firm will have some...social science theories applicable to contracting research, identify a contracting paradigm (or paradigms) and potential contracting theories and...principles, examine the nature of contracting research and practice, and present thoughts and ideas toward a general theory of contracting which, hopefully

  15. 24 CFR 983.253 - Leasing of contract units.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Leasing of contract units. 983.253... DEVELOPMENT PROJECT-BASED VOUCHER (PBV) PROGRAM Occupancy § 983.253 Leasing of contract units. (a) Owner selection of tenants. (1) During the term of the HAP contract, the owner must lease contract units only to...

  16. 9 CFR 206.2 - Swine contract library.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Swine contract library. 206.2 Section... STOCKYARDS PROGRAMS), DEPARTMENT OF AGRICULTURE SWINE CONTRACT LIBRARY § 206.2 Swine contract library. (a) Do... swine contract library will be made available to the public? GIPSA will summarize the information it has...

  17. Intelligent Systems and Technology for Integrative and Predictive Medicine: An ACP Approach.

    Science.gov (United States)

    Wang, Fei-Yue; Wong, Pak Kin

    2013-03-01

    One of the principal goals in medicine is to determine and implement the best treatment for patients through fastidious estimation of the effects and benefits of therapeutic procedures. The inherent complexities of physiological and pathological networks that span across orders of magnitude in time and length scales, however, represent fundamental hurdles in determining effective treatments for patients. Here we argue for a new approach, called ACP-based approach that combines artificial (societies), computational (experiments) and parallel (execution)methods in intelligent systems and technology for integrative and predictive medicine, or more general, precision medicine and smart health management. The advent of artificial societies that collect the clinically relevant information in prognostics and therapeutics provides a promising platform for organizing and experimenting complex physiological systems toward integrative medicine. The ability of computational experiments to analyze distinct, interactive systems such as the host mechanisms, pathological pathways, therapeutic strategies as well as other factors using the artificial systems will enable control and management through parallel execution of real and arficial systems concurrently within the integrative medicine context. The development of this framework in integrative medicine fueled by close collaborations between physicians, engineers, and scientists will result in preventive and predictive practices of personal, proactive, and precision nature, including rational combinatorial treatments, adaptive therapeutics, and patient-oriented disease management.

  18. Measurement of the direct $CP$-violating parameter $A_{CP}$ in the decay $D^+ \\to K^-\\pi^+\\pi^+$

    CERN Document Server

    Abazov, Victor Mukhamedovich; Abbott, Braden Keim; Acharya, Bannanje Sripath; Adams, Mark Raymond; Adams, Todd; Agnew, James P; Alexeev, Guennadi D; Alkhazov, Georgiy D; Alton, Andrew K; Askew, Andrew Warren; Atkins, Scott; Augsten, Kamil; Avila, Carlos A; Badaud, Frederique; Bagby, Linda F; Baldin, Boris; Bandurin, Dmitry V; Banerjee, Sunanda; Barberis, Emanuela; Baringer, Philip S; Bartlett, JFrederick; Bassler, Ursula Rita; Bazterra, Victor; Bean, Alice L; Begalli, Marcia; Bellantoni, Leo; Beri, Suman B; Bernardi, Gregorio; Bernhard, Ralf Patrick; Bertram, Iain A; Besancon, Marc; Beuselinck, Raymond; Bhat, Pushpalatha C; Bhatia, Sudeep; Bhatnagar, Vipin; Blazey, Gerald Charles; Blessing, Susan K; Bloom, Kenneth A; Boehnlein, Amber S; Boline, Daniel Dooley; Boos, Edward E; Borissov, Guennadi; Borysova, Maryna; Brandt, Andrew; Brandt, Oleg; Brock, Raymond L; Bross, Alan D; Brown, Duncan Paul; Bu, Xue-Bing; Buehler, Marc; Buescher, Volker; Bunichev, Viacheslav Yevgenyevich; Burdin, Sergey; Buszello, Claus Peter; Camacho-Perez, Enrique; Casey, Brendan Cameron Kieran; Castilla-Valdez, Heriberto; Caughron, Seth Aaron; Chakrabarti, Subhendu; Chan, Kwok Ming Leo; Chandra, Avdhesh; Chapon, Emilien; Chen, Guo; Cho, Sung-Woong; Choi, Suyong; Choudhary, Brajesh C; Cihangir, Selcuk; Claes, Daniel R; Clutter, Justace Randall; Cooke, Michael P; Cooper, William Edward; Corcoran, Marjorie D; Couderc, Fabrice; Cousinou, Marie-Claude; Cutts, David; Das, Amitabha; Davies, Gavin John; de Jong, Sijbrand Jan; De La Cruz-Burelo, Eduard; Deliot, Frederic; Demina, Regina; Denisov, Dmitri S; Denisov, Sergei P; Desai, Satish Vijay; Deterre, Cecile; DeVaughan, Kayle Otis; Diehl, HThomas; Diesburg, Michael; Ding, Pengfei; Dominguez, DAaron M; Dubey, Abhinav Kumar; Dudko, Lev V; Duperrin, Arnaud; Dutt, Suneel; Eads, Michael T; Edmunds, Daniel L; Ellison, John A; Elvira, VDaniel; Enari, Yuji; Evans, Harold G; Evdokimov, Valeri N; Faure, Alexandre; Feng, Lei; Ferbel, Thomas; Fiedler, Frank; Filthaut, Frank; Fisher, Wade Cameron; Fisk, HEugene; Fortner, Michael R; Fox, Harald; Fuess, Stuart C; Garbincius, Peter H; Garcia-Bellido, Aran; Garcia-Gonzalez, Jose Andres; Gavrilov, Vladimir B; Geng, Weigang; Gerber, Cecilia Elena; Gershtein, Yuri S; Ginther, George E; Gogota, Olga; Golovanov, Georgy Anatolievich; Grannis, Paul D; Greder, Sebastien; Greenlee, Herbert B; Grenier, Gerald Jean; Gris, Phillipe Luc; Grivaz, Jean-Francois; Grohsjean, Alexander; Gruenendahl, Stefan; Gruenewald, Martin Werner; Guillemin, Thibault; Gutierrez, Gaston R; Gutierrez, Phillip; Haley, Joseph Glenn Biddle; Han, Liang; Harder, Kristian; Harel, Amnon; Hauptman, John Michael; Hays, Jonathan M; Head, Tim; Hebbeker, Thomas; Hedin, David R; Hegab, Hatim; Heinson, Ann; Heintz, Ulrich; Hensel, Carsten; Heredia-De La Cruz, Ivan; Herner, Kenneth Richard; Hesketh, Gavin G; Hildreth, Michael D; Hirosky, Robert James; Hoang, Trang; Hobbs, John D; Hoeneisen, Bruce; Hogan, Julie; Hohlfeld, Mark; Holzbauer, Jenny Lyn; Howley, Ian James; Hubacek, Zdenek; Hynek, Vlastislav; Iashvili, Ia; Ilchenko, Yuriy; Illingworth, Robert A; Ito, Albert S; Jabeen, Shabnam; Jaffre, Michel J; Jayasinghe, Ayesh; Jeong, Min-Soo; Jesik, Richard L; Jiang, Peng; Johns, Kenneth Arthur; Johnson, Emily; Johnson, Marvin E; Jonckheere, Alan M; Jonsson, Per Martin; Joshi, Jyoti; Jung, Andreas Werner; Juste, Aurelio; Kajfasz, Eric; Karmanov, Dmitriy Y; Katsanos, Ioannis; Kaur, Manbir; Kehoe, Robert Leo Patrick; Kermiche, Smain; Khalatyan, Norayr; Khanov, Alexander; Kharchilava, Avto; Kharzheev, Yuri N; Kiselevich, Ivan Lvovich; Kohli, Jatinder M; Kozelov, Alexander V; Kraus, James Alexander; Kumar, Ashish; Kupco, Alexander; Kurca, Tibor; Kuzmin, Valentin Alexandrovich; Lammers, Sabine Wedam; Lebrun, Patrice; Lee, Hyun-Su; Lee, Seh-Wook; Lee, William M; Lei, Xiaowen; Lellouch, Jeremie; Li, Dikai; Li, Hengne; Li, Liang; Li, Qi-Zhong; Lim, Jeong Ku; Lincoln, Donald W; Linnemann, James Thomas; Lipaev, Vladimir V; Lipton, Ronald J; Liu, Huanzhao; Liu, Yanwen; Lobodenko, Alexandre; Lokajicek, Milos; Lopes de Sa, Rafael; Luna-Garcia, Rene; Lyon, Adam Leonard; Maciel, Arthur KA; Madar, Romain; Magana-Villalba, Ricardo; Malik, Sudhir; Malyshev, Vladimir L; Mansour, Jason; Martinez-Ortega, Jorge; McCarthy, Robert L; Mcgivern, Carrie Lynne; Meijer, Melvin M; Melnitchouk, Alexander S; Menezes, Diego D; Mercadante, Pedro Galli; Merkin, Mikhail M; Meyer, Arnd; Meyer, Jorg Manfred; Miconi, Florian; Mondal, Naba K; Mulhearn, Michael James; Nagy, Elemer; Narain, Meenakshi; Nayyar, Ruchika; Neal, Homer A; Negret, Juan Pablo; Neustroev, Petr V; Nguyen, Huong Thi; Nunnemann, Thomas P; Orduna, Jose de Jesus Hernandez; Osman, Nicolas Ahmed; Osta, Jyotsna; Pal, Arnab; Parashar, Neeti; Parihar, Vivek; Park, Sung Keun; Partridge, Richard A; Parua, Nirmalya; Patwa, Abid; Penning, Bjoern; Perfilov, Maxim Anatolyevich; Peters, Reinhild Yvonne Fatima; Petridis, Konstantinos; Petrillo, Gianluca; Petroff, Pierre; Pleier, Marc-Andre; Podstavkov, Vladimir M; Popov, Alexey V; Prewitt, Michelle; Price, Darren; Prokopenko, Nikolay N; Qian, Jianming; Quadt, Arnulf; Quinn, Breese; Ratoff, Peter N; Razumov, Ivan A; Ripp-Baudot, Isabelle; Rizatdinova, Flera; Rominsky, Mandy Kathleen; Ross, Anthony; Royon, Christophe; Rubinov, Paul Michael; Ruchti, Randal C; Sajot, Gerard; Sanchez-Hernandez, Alberto; Sanders, Michiel P; Santos, Angelo Souza; Savage, David G; Savitskyi, Mykola; Sawyer, HLee; Scanlon, Timothy P; Schamberger, RDean; Scheglov, Yury A; Schellman, Heidi M; Schwanenberger, Christian; Schwienhorst, Reinhard H; Sekaric, Jadranka; Severini, Horst; Shabalina, Elizaveta K; Shary, Viacheslav V; Shaw, Savanna; Shchukin, Andrey A; Simak, Vladislav J; Skubic, Patrick Louis; Slattery, Paul F; Smirnov, Dmitri V; Snow, Gregory R; Snow, Joel Mark; Snyder, Scott Stuart; Soldner-Rembold, Stefan; Sonnenschein, Lars; Soustruznik, Karel; Stark, Jan; Stoyanova, Dina A; Strauss, Michael G; Suter, Louise; Svoisky, Peter V; Titov, Maxim; Tokmenin, Valeriy V; Tsai, Yun-Tse; Tsybychev, Dmitri; Tuchming, Boris; Tully, Christopher George T; Uvarov, Lev; Uvarov, Sergey L; Uzunyan, Sergey A; Van Kooten, Richard J; van Leeuwen, Willem M; Varelas, Nikos; Varnes, Erich W; Vasilyev, Igor A; Verkheev, Alexander Yurievich; Vertogradov, Leonid S; Verzocchi, Marco; Vesterinen, Mika; Vilanova, Didier; Vokac, Petr; Wahl, Horst D; Wang, Michael HLS; Warchol, Jadwiga; Watts, Gordon Thomas; Wayne, Mitchell R; Weichert, Jonas; Welty-Rieger, Leah Christine; Williams, Mark Richard James; Wilson, Graham Wallace; Wobisch, Markus; Wood, Darien Robert; Wyatt, Terence R; Xie, Yunhe; Yamada, Ryuji; Yang, Siqi; Yasuda, Takahiro; Yatsunenko, Yuriy A; Ye, Wanyu; Ye, Zhenyu; Yin, Hang; Yip, Kin; Youn, Sungwoo; Yu, Jiaming; Zennamo, Joseph; Zhao, Tianqi Gilbert; Zhou, Bing; Zhu, Junjie; Zielinski, Marek; Zieminska, Daria; Zivkovic, Lidija

    2014-01-01

    We measure the direct CP-violating parameter A_CP for the decay of the charged charm meson, D+ -> K-pi+pi+ (and charge conjugate), using the full 10.4 fb-1 sample of ppbar collisions at sqrt(s) = 1.96 TeV collected by the D0 detector at the Fermilab Tevatron collider. We extract the raw reconstructed charge asymmetry by fitting the invariant mass distributions for the sum and difference of charge-specific samples. This quantity is then corrected for detector-related asymmetries using data-driven methods and for possible physics asymmetries (from B -> D processes) using input from Monte Carlo simulation. We measure A_CP = [-0.16 +- 0.15 (stat.) +- 0.09 (syst.)]%, which is consistent with zero, as expected from the standard model prediction of CP conservation, and is the most precise measurement of this quantity to date

  19. Measurement of the direct $CP$-violating parameter $A_{CP}$ in the decay $D^+ \\to K^-\\pi^+\\pi^+$

    CERN Document Server

    Abazov, Victor Mukhamedovich; Acharya, Bannanje Sripath; Adams, Mark Raymond; Adams, Todd; Agnew, James P; Alexeev, Guennadi D; Alkhazov, Georgiy D; Alton, Andrew K; Askew, Andrew Warren; Atkins, Scott; Augsten, Kamil; Avila, Carlos A; Badaud, Frederique; Bagby, Linda F; Baldin, Boris; Bandurin, Dmitry V; Banerjee, Sunanda; Barberis, Emanuela; Baringer, Philip S; Bartlett, JFrederick; Bassler, Ursula Rita; Bazterra, Victor; Bean, Alice L; Begalli, Marcia; Bellantoni, Leo; Beri, Suman B; Bernardi, Gregorio; Bernhard, Ralf Patrick; Bertram, Iain A; Besancon, Marc; Beuselinck, Raymond; Bhat, Pushpalatha C; Bhatia, Sudeep; Bhatnagar, Vipin; Blazey, Gerald Charles; Blessing, Susan K; Bloom, Kenneth A; Boehnlein, Amber S; Boline, Daniel Dooley; Boos, Edward E; Borissov, Guennadi; Borysova, Maryna; Brandt, Andrew; Brandt, Oleg; Brock, Raymond L; Bross, Alan D; Brown, Duncan Paul; Bu, Xue-Bing; Buehler, Marc; Buescher, Volker; Bunichev, Viacheslav Yevgenyevich; Burdin, Sergey; Buszello, Claus Peter; Camacho-Perez, Enrique; Casey, Brendan Cameron Kieran; Castilla-Valdez, Heriberto; Caughron, Seth Aaron; Chakrabarti, Subhendu; Chan, Kwok Ming Leo; Chandra, Avdhesh; Chapon, Emilien; Chen, Guo; Cho, Sung-Woong; Choi, Suyong; Choudhary, Brajesh C; Cihangir, Selcuk; Claes, Daniel R; Clutter, Justace Randall; Cooke, Michael P; Cooper, William Edward; Corcoran, Marjorie D; Couderc, Fabrice; Cousinou, Marie-Claude; Cutts, David; Das, Amitabha; Davies, Gavin John; de Jong, Sijbrand Jan; De La Cruz-Burelo, Eduard; Deliot, Frederic; Demina, Regina; Denisov, Dmitri S; Denisov, Sergei P; Desai, Satish Vijay; Deterre, Cecile; DeVaughan, Kayle Otis; Diehl, HThomas; Diesburg, Michael; Ding, Pengfei; Dominguez, DAaron M; Dubey, Abhinav Kumar; Dudko, Lev V; Duperrin, Arnaud; Dutt, Suneel; Eads, Michael T; Edmunds, Daniel L; Ellison, John A; Elvira, VDaniel; Enari, Yuji; Evans, Harold G; Evdokimov, Valeri N; Faure, Alexandre; Feng, Lei; Ferbel, Thomas; Fiedler, Frank; Filthaut, Frank; Fisher, Wade Cameron; Fisk, HEugene; Fortner, Michael R; Fox, Harald; Fuess, Stuart C; Garbincius, Peter H; Garcia-Bellido, Aran; Garcia-Gonzalez, Jose Andres; Gavrilov, Vladimir B; Geng, Weigang; Gerber, Cecilia Elena; Gershtein, Yuri S; Ginther, George E; Gogota, Olga; Golovanov, Georgy Anatolievich; Grannis, Paul D; Greder, Sebastien; Greenlee, Herbert B; Grenier, Gerald Jean; Gris, Phillipe Luc; Grivaz, Jean-Francois; Grohsjean, Alexander; Gruenendahl, Stefan; Gruenewald, Martin Werner; Guillemin, Thibault; Gutierrez, Gaston R; Gutierrez, Phillip; Haley, Joseph Glenn Biddle; Han, Liang; Harder, Kristian; Harel, Amnon; Hauptman, John Michael; Hays, Jonathan M; Head, Tim; Hebbeker, Thomas; Hedin, David R; Hegab, Hatim; Heinson, Ann; Heintz, Ulrich; Hensel, Carsten; Heredia-De La Cruz, Ivan; Herner, Kenneth Richard; Hesketh, Gavin G; Hildreth, Michael D; Hirosky, Robert James; Hoang, Trang; Hobbs, John D; Hoeneisen, Bruce; Hogan, Julie; Hohlfeld, Mark; Holzbauer, Jenny Lyn; Howley, Ian James; Hubacek, Zdenek; Hynek, Vlastislav; Iashvili, Ia; Ilchenko, Yuriy; Illingworth, Robert A; Ito, Albert S; Jabeen, Shabnam; Jaffre, Michel J; Jayasinghe, Ayesh; Jeong, Min-Soo; Jesik, Richard L; Jiang, Peng; Johns, Kenneth Arthur; Johnson, Emily; Johnson, Marvin E; Jonckheere, Alan M; Jonsson, Per Martin; Joshi, Jyoti; Jung, Andreas Werner; Juste, Aurelio; Kajfasz, Eric; Karmanov, Dmitriy Y; Katsanos, Ioannis; Kaur, Manbir; Kehoe, Robert Leo Patrick; Kermiche, Smain; Khalatyan, Norayr; Khanov, Alexander; Kharchilava, Avto; Kharzheev, Yuri N; Kiselevich, Ivan Lvovich; Kohli, Jatinder M; Kozelov, Alexander V; Kraus, James Alexander; Kumar, Ashish; Kupco, Alexander; Kurca, Tibor; Kuzmin, Valentin Alexandrovich; Lammers, Sabine Wedam; Lebrun, Patrice; Lee, Hyeon-Seung; Lee, Seh-Wook; Lee, William M; Lei, Xiaowen; Lellouch, Jeremie; Li, Dikai; Li, Hengne; Li, Liang; Li, Qi-Zhong; Lim, Jeong Ku; Lincoln, Donald W; Linnemann, James Thomas; Lipaev, Vladimir V; Lipton, Ronald J; Liu, Huanzhao; Liu, Yanwen; Lobodenko, Alexandre; Lokajicek, Milos; Lopes de Sa, Rafael; Luna-Garcia, Rene; Lyon, Adam Leonard; Maciel, Arthur KA; Madar, Romain; Magana-Villalba, Ricardo; Malik, Sudhir; Malyshev, Vladimir L; Mansour, Jason; Martinez-Ortega, Jorge; McCarthy, Robert L; Mcgivern, Carrie Lynne; Meijer, Melvin M; Melnitchouk, Alexander S; Menezes, Diego D; Mercadante, Pedro Galli; Merkin, Mikhail M; Meyer, Arnd; Meyer, Jorg Manfred; Miconi, Florian; Mondal, Naba K; Mulhearn, Michael James; Nagy, Elemer; Narain, Meenakshi; Nayyar, Ruchika; Neal, Homer A; Negret, Juan Pablo; Neustroev, Petr V; Nguyen, Huong Thi; Nunnemann, Thomas P; Hernandez Orduna, Jose de Jesus; Osman, Nicolas Ahmed; Osta, Jyotsna; Pal, Arnab; Parashar, Neeti; Parihar, Vivek; Park, Sung Keun; Partridge, Richard A; Parua, Nirmalya; Patwa, Abid; Penning, Bjoern; Perfilov, Maxim Anatolyevich; Peters, Reinhild Yvonne Fatima; Petridis, Konstantinos; Petrillo, Gianluca; Petroff, Pierre; Pleier, Marc-Andre; Podstavkov, Vladimir M; Popov, Alexey V; Prewitt, Michelle; Price, Darren; Prokopenko, Nikolay N; Qian, Jianming; Quadt, Arnulf; Quinn, Breese; Ratoff, Peter N; Razumov, Ivan A; Ripp-Baudot, Isabelle; Rizatdinova, Flera; Rominsky, Mandy Kathleen; Ross, Anthony; Royon, Christophe; Rubinov, Paul Michael; Ruchti, Randal C; Sajot, Gerard; Sanchez-Hernandez, Alberto; Sanders, Michiel P; Santos, Angelo Souza; Savage, David G; Savitskyi, Mykola; Sawyer, HLee; Scanlon, Timothy P; Schamberger, RDean; Scheglov, Yury A; Schellman, Heidi M; Schwanenberger, Christian; Schwienhorst, Reinhard H; Sekaric, Jadranka; Severini, Horst; Shabalina, Elizaveta K; Shary, Viacheslav V; Shaw, Savanna; Shchukin, Andrey A; Simak, Vladislav J; Skubic, Patrick Louis; Slattery, Paul F; Smirnov, Dmitri V; Snow, Gregory R; Snow, Joel Mark; Snyder, Scott Stuart; Soldner-Rembold, Stefan; Sonnenschein, Lars; Soustruznik, Karel; Stark, Jan; Stoyanova, Dina A; Strauss, Michael G; Suter, Louise; Svoisky, Peter V; Titov, Maxim; Tokmenin, Valeriy V; Tsai, Yun-Tse; Tsybychev, Dmitri; Tuchming, Boris; Tully, Christopher George T; Uvarov, Lev; Uvarov, Sergey L; Uzunyan, Sergey A; Van Kooten, Richard J; van Leeuwen, Willem M; Varelas, Nikos; Varnes, Erich W; Vasilyev, Igor A; Verkheev, Alexander Yurievich; Vertogradov, Leonid S; Verzocchi, Marco; Vesterinen, Mika; Vilanova, Didier; Vokac, Petr; Wahl, Horst D; Wang, Michael HLS; Warchol, Jadwiga; Watts, Gordon Thomas; Wayne, Mitchell R; Weichert, Jonas; Welty-Rieger, Leah Christine; Williams, Mark Richard James; Wilson, Graham Wallace; Wobisch, Markus; Wood, Darien Robert; Wyatt, Terence R; Xie, Yunhe; Yamada, Ryuji; Yang, Siqi; Yasuda, Takahiro; Yatsunenko, Yuriy A; Ye, Wanyu; Ye, Zhenyu; Yin, Hang; Yip, Kin; Youn, Sungwoo; Yu, Jiaming; Zennamo, Joseph; Zhao, Tianqi Gilbert; Zhou, Bing; Zhu, Junjie; Zielinski, Marek; Zieminska, Daria; Zivkovic, Lidija

    2014-12-11

    We measure the direct CP-violating parameter A_CP for the decay of the charged charm meson, D+ -> K-pi+pi+ (and charge conjugate), using the full 10.4 fb-1 sample of ppbar collisions at sqrt(s) = 1.96 TeV collected by the D0 detector at the Fermilab Tevatron collider. We extract the raw reconstructed charge asymmetry by fitting the invariant mass distributions for the sum and difference of charge-specific samples. This quantity is then corrected for detector-related asymmetries using data-driven methods and for possible physics asymmetries (from B -> D processes) using input from Monte Carlo simulation. We measure A_CP = [-0.16 +- 0.15 (stat.) +- 0.09 (syst.)]%, which is consistent with zero, as expected from the standard model prediction of CP conservation, and is the most precise measurement of this quantity to date

  20. Evolution of the AKH/corazonin/ACP/GnRH receptor superfamily and their ligands in the Protostomia

    DEFF Research Database (Denmark)

    Hauser, Frank; Grimmelikhuijzen, Cornelis

    2014-01-01

    In this review we trace the evolutionary connections between GnRH receptors from vertebrates and the receptors for adipokinetic hormone (AKH), AKH/corazonin-related peptide (ACP), and corazonin from arthropods. We conclude that these G protein-coupled receptors (GPCRs) are closely related and hav......QLTFSSDWSGamide), and the penis worm Priapulus caudatus (pQIFFSKGWRGamide). This is the first report, showing that AKH signaling is widespread in molluscs....

  1. European Union supports project to strengthen fisheries and biodiversity management in African, Caribbean, and Pacific (ACP) countries

    OpenAIRE

    Vakily, J.M.; Froese, R.; Palomares, M.L.D.; Pauly, D

    1997-01-01

    Proper resource management implies a better understanding of ecosystems and the conservation of biodiversity. Scientists from developing countries often have limited information on their aquatic resources because of many difficulties in accessing and exchanging information on a national and international level. The project described not only aims to strengthen the scientific capacity of fisheries scientists in ACP institutions but it is also expected to create an awareness among fisheries res...

  2. In silico Analysis and Modeling of ACP-MIP–PilQ Chimeric Antigen from Neisseria meningitidis Serogroup B

    OpenAIRE

    Mehrdad Gholami; Alireza Salimi Chirani; Mona Moshiri; Mansour Sedighi; Abazar Pournajaf; Masoud Tohidfar; Gholamreza Irajian

    2015-01-01

    Background: Neisseria meningitidis, a life-threatening human pathogen with the potential to cause large epidemics, can be isolated from the nasopharynx of 5–15% of adults. The aim of the current study was to evaluate biophysical and biochemical properties and immunological aspects of chimeric acyl-carrier protein-macrophage infectivity potentiator protein-type IV pilus biogenesis protein antigen (ACP-MIP-PilQ) from N. meningitidis serogroup B strain. Methods: Biochemical properties and mul...

  3. Tooth whitening with hydrogen/carbamide peroxides in association with a CPP-ACP paste at different proportions.

    Science.gov (United States)

    de Vasconcelos, A A M; Cunha, A G G; Borges, B C D; Machado, C T; dos Santos, A J S

    2012-06-01

    Different enhanced peroxide formulations have been developed to overcome mineral loss during tooth whitening. This study investigated the impact on tooth whitening from combining a CPP-ACP paste with home peroxide agents at several proportions. Ninety bovine incisors were randomly allocated into nine groups (n = 10) and exposed to 7.5% hydrogen peroxide (HP), 16% carbamide peroxide (CP), a CPP-ACP paste (Tooth Mousse/MI Paste, GC Corporation, Tokyo, Japan) and blends of HP/CP:MI at three proportions (1:1, 2:1 and 1:2). Tooth whitening was performed for 14 days and its effectiveness was measured by a spectrophotometer utilizing the CIE L*a*b* system (ΔE, ΔL*, Δa* and Δb*). Colour readings were measured at baseline (T0), 7 days of bleaching (T7), 14 days of bleaching (T14) and 7 days after the end of bleaching (T21). Data were analysed by two-way ANOVA for paired averages followed by the Tukey's test and Pearson's correlation at 5%. Although CP produced the greatest colour change (ΔE), all whitening protocols were considered to be effective regardless of the CPP-ACP presence. In general, greater changes in ΔE, ΔL*, Δa* and Δb* were detected at T14, with T21 exhibiting similar results to those at T7. A greater number of strong correlations with ΔE values was found for a* (11/15). Within the limitations of this study, the results indicate that the CPP-ACP paste did not affect tooth whitening efficacy. © 2012 Australian Dental Association.

  4. DIFFERENT CONCENTRATIONS OF POWDERED EGG YOLK ADDED TO THE ACP-103® EXTENDER IN SWINE SEMEN CONSERVATION

    Directory of Open Access Journals (Sweden)

    Ricardo Toniolli

    2016-04-01

    Full Text Available Many attempts have been made to improve the conservation of boar semen. Egg yolk is known to have cryoprotectant properties. This study aimed to test different concentrations of egg yolk added to the coconut milk powder extender (ACP-103®, and verify which one is better to maintain sperm viability. The ejaculated (36 were diluted in ACP-103® supplemented with different concentrations of egg yolk (0%, 1%, 3%, 5% and 7%. The conservation occurred at 17 °C, and vigor and motility analysis were carried out daily. On days 1 (D0, 3 (D2 and 5 (D4 the semen was evaluated for vitality, morphology and osmotic resistance. For statistical nonparametric analysis Kruskal-Wallis and Dunn’s tests were performed, and for parametric data ANOVA and Tukey test were used. A decrease in vigor and motility was observed in all treatments. Treatments T2, T3 and T4 better maintained spermatic on D0 (2.4±0.8, 2.5±1.1, and 2.8±0.9, respectively, with no signi cant differences among them. The same was observed for motility (77±15%, 74±23%, and 81±16% on D0. Analyses of vitality, morphology and osmotic resistance did not show statistical difference among treatments. In conclusion, the concentration of egg yolk (7% added to the ACP-103® can be e ectively used as extender to maintain sperm viability.

  5. Conventional cytogenetic characterization of a new cell line, ACP01, established from a primary human gastric tumor

    Directory of Open Access Journals (Sweden)

    E.M. Lima

    2004-12-01

    Full Text Available Gastric cancer is the second most frequent type of neoplasia and also the second most important cause of death in the world. Virtually all the established cell lines of gastric neoplasia were developed in Asian countries, and western countries have contributed very little to this area. In the present study we describe the establishment of the cell line ACP01 and characterize it cytogenetically by means of in vitro immortalization. Cells were transformed from an intestinal-type gastric adenocarcinoma (T4N2M0 originating from a 48-year-old male patient. This is the first gastric adenocarcinoma cell line established in Brazil. The most powerful application of the cell line ACP01 is in the assessment of cytotoxicity. Solid tumor cell lines from different origins have been treated with several conventional and investigational anticancer drugs. The ACP01 cell line is triploid, grows as a single, non-organized layer, similar to fibroblasts, with focus formation, heterogeneous division, and a cell cycle of approximately 40 h. Chromosome 8 trisomy, present in 60% of the cells, was the most frequent cytogenetic alteration. These data lead us to propose a multifactorial triggering of gastric cancer which evolves over multiple stages involving progressive genetic changes and clonal expansion.

  6. Treatment of post-orthodontic white spot lesions with CPP-ACP paste: A three year follow up study.

    Science.gov (United States)

    Karabekiroğlu, Said; Ünlü, Nimet; Küçükyilmaz, Ebru; Şener, Sevgi; Botsali, Murat Selim; Malkoç, Sıddık

    2017-11-29

    To determine the efficacy of topical applications of 10% casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) paste in reverting white spot lesions (WSLs) after fixed orthodontic treatment. Forty one participants were randomly assigned to either the test group (CPP-ACP) or the control group (only fluoride toothpaste). All patients used regular fluoride-containing toothpaste. CPPACP paste or fluoridated toothpaste was applied on to tooth surfaces with WSLs twice a day during 36-month after de-bonding. The labial/buccal surfaces of teeth were assessed by use of DIAGNOdent pen (DD), Gorelick Index and ICDAS II criteria at baseline (T1) and 36-month (T2) follow-up visits. The total counts of Streptococcus mutans and Lactobacillus were obtained at T1 and T2. DMFT, DMFS, stimulated flow rate and buffer capacity were calculated in two appointments. Daily usage of CPP-ACP paste was not better than normal care for improving the appearance of WSLs after 36 months.

  7. An ordered reaction mechanism for bacterial toxin acylation by the specialized acyltransferase HlyC: formation of a ternary complex with acylACP and protoxin substrates

    National Research Council Canada - National Science Library

    Stanley, Peter; Hyland, Caroline; Koronakis, Vassilis; Hughes, Colin

    1999-01-01

    .... Using an in vitro maturation reaction containing purified protoxin peptides and acylACP, we show unambiguously that HlyC possesses an apparently unique acyltransferase activity fully described by Michaelis–Menten analysis...

  8. ACP-EU fisheries research initiative: proceedings of the EXPO '98 conference : Ocean Food Webs and Economic Productivity : Lisbon, Portugal, 1-3 July 1998

    National Research Council Canada - National Science Library

    Pauly, D; Christensen, V; Coelho, L

    1999-01-01

    This report presents the proceedings of a three day scientific conference on "Ocean Food Webs and Economic Productivity", held under the auspices of the ACP-EU Fisheries Research Initiative and the European Commission...

  9. The relevance of SPS in the ACP-EU economic partnership agreements: What a development-friendly recognition of SPS measures within the EPA negotiations might look like

    OpenAIRE

    Chemnitz, Christine; Günther, Doris

    2007-01-01

    The Africa Caribbean and Pacific (ACP) countries have benefited from unilateral preferential access to EU markets under various trade agreements. However, since agricultural trade is increasingly determined by food safety and quality standards, one of the main concerns of ACP countries is their inability to benefit from their preferential status due to their lack of compliance with EU food quality requirements. Recently, this dilemma has become of particular interest because the unilateral pr...

  10. 48 CFR 1823.570-2 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... Program,” and in other solicitations and contracts exceeding $5 million in which work is performed by an employee in a sensitive position. However, the contracting officer shall not insert the clause at 1852.223...

  11. EFFECTS OF COMMERCIAL CONTRACT

    OpenAIRE

    Ana-Maria Florea; Constantin Giurca

    2014-01-01

    The contract is a legal instrument used to organize economic and social life. International trade agreement has certain features in order to ensure the international exchange of goods and services between the Contracting Parties. In terms of commercial contract, there is a foreign origin element, that gives the parties the right to determine the law to govern the contract. A fundamental aspect of commercial contract, in addition to that of determining the law applicable to judicial report est...

  12. Education Performance Contracting: The Dallas Project.

    Science.gov (United States)

    Estes, Nolan

    This report discusses performance contracting as one means of implementing educational accountability. It describes the planning for and main features of the Dallas, Texas, performance contract -- the Guaranteed Student Performance in Education and Training Program that uses a multifaceted approach to remove math, reading, and motivation…

  13. 48 CFR 1424.104 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 1424.104 Section 1424.104 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR SOCIOECONOMIC PROGRAMS PROTECTION OF PRIVACY AND FREEDOM OF INFORMATION Protection of Individual Privacy 1424.104 Contract clauses...

  14. Educational contracts in family medicine residency training.

    OpenAIRE

    Mahood, S.; Rojas, R.; Andres, D.; Zagozeski, C.; White, G.; Bradel, T.

    1994-01-01

    An educational contract for family medicine residency training and evaluation addresses many of the difficulties and challenges of current postgraduate medical education. This article identifies important principles for developing a contractual approach; describes the contract used in one program and its implementation; and discusses its theory, advantages, and limitations.

  15. In situ Effect of Chewing Gum with and without CPP-ACP on Enamel Surface Hardness Subsequent to ex vivo Acid Challenge.

    Science.gov (United States)

    Jordão, M C; Alencar, C R B; Mesquita, I M; Buzalaf, M A R; Magalhães, A C; Machado, M A A M; Honório, H M; Rios, D

    2016-01-01

    The erosion-protective effect of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) is controversial. This study aimed to investigate the ability of CPP-ACP chewing gum to prevent a single event of erosive demineralization in situ. Bovine enamel blocks (n = 120) were randomly assigned to 3 phases according to the baseline surface hardness: phase I (PI) - chewing gum with CPP-ACP, phase II (PII) - chewing gum without CPP-ACP, and control phase (PIII) - salivary effect without stimulation (no gum). Nineteen volunteers participated in this study during 3 crossover phases of 2 h. In PI and PII, the volunteers wore intraoral palatal appliances for 120 min and chewed a unit of the corresponding chewing gum for the final 30 min. In the control phase the volunteers wore the appliance for 2 h, without chewing gum. Immediately after intraoral use, the appliances were extraorally immersed in a cola drink for 5 min to promote erosive demineralization. The percentage of surface hardness loss was calculated. The data were analyzed by ANOVA models and Tukey's test. Lower enamel hardness loss was found after the use of chewing gum with CPP-ACP (PI: 32.7%) and without CPP-ACP (PII: 33.5%) compared to the salivary effect without stimulation (PIII: 39.8%) (p 0.05). The results suggest that the use of chewing gum immediately before an erosive demineralization can diminish enamel hardness loss. However, the presence of CPP-ACP in the chewing gum cannot enhance this protective effect. © 2016 S. Karger AG, Basel.

  16. Concentration of Calcium, Phosphate and Fluoride Ions in Microbial Plaque and Saliva after Using CPP-ACP Paste in 6-9 year-old Children.

    Science.gov (United States)

    Hr, Poureslami; Ra, Hoseinifar; Re, Hoseinifar; H, Sharifi; P, Poureslami

    2016-06-01

    Dental caries is one of the most common chronic diseases in children. The balance between demineralization and remineralization of the decayed teeth depends on the calcium and phosphate content of the tooth surface. Therefore, if a product such as casein phospho peptides - amorphous calcium phosphate (CPP- ACP) which can significantly increase the availability of calcium and phosphate in the plaque and saliva should have an anti-caries protective effect. The purpose of this study was to evaluate the concentration of calcium, phosphate and fluoride in the plaque and saliva of children before and after applying the CPP-ACP paste. A total of 25 children aged between 6-9 years were selected for this clinical trial study. At first, 1 ml of unstimulated saliva was collected and then 1 mg of the plaque sample was collected from the buccal surfaces of the two first primary molars on the upper jaw. In the next step, CPP-ACP paste (GC Corp, Japan) was applied on the tooth surfaces and then the plaque and saliva sampling was performed after 60 minutes. The amount of calcium ions was measured by Ion meter instrument (Metrohm Co, Swiss) and the amounts of phosphate and fluoride ions were measured by Ion Chromatography instrument (Metrohm Co, Swiss). Data were analyzed using paired t-test at a p paste. There were also statistically significant differences in the fluoride levels of the plaque before and after applying the CPP-ACP paste. However, there were no statistically significant differences in the fluoride levels of the saliva before and after applying the CPP-ACP paste. In this study, the use of the CPP-ACP paste significantly increased the fluoride levels of the plaque and the calcium and phosphate levels of both saliva and plaque. Hence, CPP-ACP paste can facilitate the remineralization of tooth surfaces and is useful for protecting the primary teeth.

  17. The CPP-ACP relieved enamel erosion from a carbonated soft beverage: an in vitro AFM and XRD study.

    Science.gov (United States)

    Wang, C P; Huang, S B; Liu, Y; Li, J Y; Yu, H Y

    2014-03-01

    To investigate the CPP-ACP's effect on enamel against carbonated beverage erosion and explore the potential mechanism. A total of 30 enamel samples were prepared from sound bovine incisors, divided into 3 groups. Samples in the control group were kept in artificial saliva. Specimens' surfaces were smeared with a CPP-ACP agent (Tooth Mousse, TM) for 3 min, rinsed with distilled water for 10s, merged into cola (Coca Cola, CC) for 4 intervals of 2 min, rinsed again for the TM+CC group. In the CC group, specimens were treated solely with cola for 4 intervals (2 min each). The cycles were applied at 0, 12, 24, 36, 48 and 60 h. The surface microhardness (SMH) alterations were measured using a microhardness tester, the surface profiles were analyzed using the atomic force microscope, and the surface crystalline amount (I%) and crystallinity (FWHM) were analyzed using X-ray diffractometer. The SMH were significantly decreased in CC group, showing the largest SMH alteration; the reduction of SMH in TM+CC group was lower than that in CC group, still larger than control. After cycles, the TM+CC group showed rougher surfaces than control, while the CC group had the roughest surfaces. The TM+CC had an I% higher than the CC, and lower than the control. The TM+CC group had a FWHM lower than CC, higher than control. CPP-ACP was able to relieve the erosion on enamel from carbonated beverage. Copyright © 2013 Elsevier Ltd. All rights reserved.

  18. iACP-GAEnsC: Evolutionary genetic algorithm based ensemble classification of anticancer peptides by utilizing hybrid feature space.

    Science.gov (United States)

    Akbar, Shahid; Hayat, Maqsood; Iqbal, Muhammad; Jan, Mian Ahmad

    2017-06-01

    Cancer is a fatal disease, responsible for one-quarter of all deaths in developed countries. Traditional anticancer therapies such as, chemotherapy and radiation, are highly expensive, susceptible to errors and ineffective techniques. These conventional techniques induce severe side-effects on human cells. Due to perilous impact of cancer, the development of an accurate and highly efficient intelligent computational model is desirable for identification of anticancer peptides. In this paper, evolutionary intelligent genetic algorithm-based ensemble model, 'iACP-GAEnsC', is proposed for the identification of anticancer peptides. In this model, the protein sequences are formulated, using three different discrete feature representation methods, i.e., amphiphilic Pseudo amino acid composition, g-Gap dipeptide composition, and Reduce amino acid alphabet composition. The performance of the extracted feature spaces are investigated separately and then merged to exhibit the significance of hybridization. In addition, the predicted results of individual classifiers are combined together, using optimized genetic algorithm and simple majority technique in order to enhance the true classification rate. It is observed that genetic algorithm-based ensemble classification outperforms than individual classifiers as well as simple majority voting base ensemble. The performance of genetic algorithm-based ensemble classification is highly reported on hybrid feature space, with an accuracy of 96.45%. In comparison to the existing techniques, 'iACP-GAEnsC' model has achieved remarkable improvement in terms of various performance metrics. Based on the simulation results, it is observed that 'iACP-GAEnsC' model might be a leading tool in the field of drug design and proteomics for researchers. Copyright © 2017 Elsevier B.V. All rights reserved.

  19. Influence of biofilm formation on the mechanical properties of enamel after treatment with CPP-ACP crème

    Directory of Open Access Journals (Sweden)

    Patrícia Regina Almeida de Oliveira

    2017-11-01

    Full Text Available Abstract: The study aimed to investigate the effects of bacterial biofilms on changes in the surface microhardness of enamel treated with casein phosphopeptide—amorphous calcium phosphate (CPP-ACP with and without fluoride. Human enamel blocks with incipient caries-like lesions were divided into four groups of 13: G1: Saliva (Control; G2: fluoride dentifrice (Crest™, 1100 ppm as NaF; G3: CPP-ACP (MI Paste; Recaldent™; and G4: CPP-ACPF (MI Paste Plus; Recaldent™ 900 ppm as NaF. The specimens were soaked in demineralizing solution for 6 h and remineralized in artificial saliva for 18 h alternately for 10 days. The dentifrice was prepared with deionized water in a 1 : 3 ratio (w/w or applied undiluted in the case of the CPP-ACP group. The surface microhardness (SMH was evaluated at baseline, after artificial caries, after pH cycling and treatment with dentifrices, and after incubation in media with Streptococcus mutans for biofilm formation. The biofilms were exposed once a day to 2% sucrose and the biofilm viability was measured by MTT reduction. The percentage of change in surface microhardness (%SMHC was calculated for each block. The data were analyzed by nonparametric test comparisons (α = 0.05. The %SMHC values observed in G2 were different from those of G1, G3, and G4 (p < 0.05. After biofilm formation, %SMHC was positive in G2 and G4 when compared to G1 and G3, but resistance to demineralization after biofilm formation was similar in all groups. In conclusion, the presence of biofilms did not influence the treatment outcomes of anticaries products.

  20. Annexe électronique : Indicateurs sociaux et scolaires retenus pour les analyses en composantes principales (ACP) et les graphiques

    OpenAIRE

    Heurdier, Lydie

    2017-01-01

    Les objectifs d’une analyse en composantes principales (ACP) sont de deux ordres : décrire les liaisons entre les variables, décrire les ressemblances et les différences entre les individus. Dans cette recherche, les individus sont les collèges, et les variables numériques retenues sont les indicateurs sociaux et scolaires, donc des données quantitatives. Les composantes principales (CP) sont hiérarchisées, la CP1 donnant le maximum d’information, c’est elle qui est retenue et figure dans le...

  1. 42 CFR 423.505 - Contract provisions.

    Science.gov (United States)

    2010-10-01

    ... period and 10 prior periods. (iii) Federal income tax or informational returns for the current contract... making recommendations for improving the economy, efficiency, or effectiveness of the Medicare program...

  2. ADMINISTRATIVE CONTRACTS. DELIMITATIONS

    Directory of Open Access Journals (Sweden)

    Liana Teodora PASCARIU

    2016-12-01

    Full Text Available Article examines whether all contracts of public persons are administrative contracts; in other words, if the administration may conclude contracts that, according to their legal nature, are not administrative. If we start from the definition of administrative contracts as it appears in Law no. 554/2004, these include contracts by public authorities which concern the enhancement of public property execution of works of public interest, public services, public procurement and other administrative contracts provided by special laws and subject to the jurisdiction of the administrative courts.

  3. Incentive contracts for development projects

    Science.gov (United States)

    Finley, David T.; Smith, Byron; DeGroff, B.

    2012-09-01

    Finding a contract vehicle that balances the concerns of the customer and the contractor in a development project can be difficult. The customer wants a low price and an early delivery, with as few surprises as possible as the project progresses. The contractor wants sufficient cost and schedule to cover risk. Both want to clearly define what each party will provide. Many program offices do not want to award cost plus contracts because their funding sources will not allow it, their boards do not want an open ended commitment, and they feel like they lose financial control of the project. A fixed price incentive contract, with a mutually agreed upon target cost, provides the owner with visibility into the project and input into the execution of the project, encourages both parties to save costs, and stimulates a collaborative atmosphere by aligning the respective interests of customers and contractors.

  4. Effect of casein phosphopeptide-amorphous calcium phosphate (cpp-acp on caries-like lesions in terms of time and nano-hardness: An in vitro study

    Directory of Open Access Journals (Sweden)

    Shanthan Mettu

    2015-01-01

    Full Text Available Context: Time bound increase in the nanohardness of the enamel after remineralization with casein phosphopeptide-amorphous calcium phosphate (CPP-ACP in a regular interval of 1 h has not been explored in the literature to a greater extent. Aims: To determine and compare the maximum hardness of the remineralized caries-like lesions, in terms of nanohardness and the rate of achieving maximum hardness at 1-h interval, after treatment with artificial saliva and CPP-ACP, over 12 h. Materials and Methods: Fifty longitudinal sections of extracted sound permanent maxillary central, lateral incisors were immersed in demineralizing solution for 4 days. The samples were then randomly divided into three groups, consisting of 12 sections each for soaking them in three different media-isotonic saline, artificial saliva, and CPP-ACP for 12 h. The nanohardness was measured on the labial surface, at baseline, after erosion, and after remineralization at 1-h interval. Statistical Analysis Used: The data was analyzed with paired t-test, one-way analysis of variance (ANOVA and post-hoc analysis. Results: CPP-ACP increased the enamel hardness significantly (P < 0.001, at an increased rate, than artificial saliva. Conclusions: This study has provided an insight into the frequency of use of CPP-ACP, once per day, as the nanohardness of enamel samples increased within 1 h of application and remained within the normal limits after 12 h.

  5. Short-term preservation of Pecari tajacu ovarian preantral follicles using phosphate buffered saline (PBS or powdered coconut water (ACP(r media

    Directory of Open Access Journals (Sweden)

    G.L. Lima

    2014-12-01

    Full Text Available We compare protocols for the short-term preservation of collared peccarie's ovarian preantral follicles (PFs by using phosphate buffered saline- (PBS or powdered coconut water- (ACP(r based medium. For morphology analysis each pair of ovaries collected from six females was divided into nine fragments. One fragment was destined for morphology analysis (histology and transmission electron microscopy - TEM, constituting the control group and the other fragments were placed in tubes with PBS or ACP(r, packed in 5 L Styrofoam boxes, stored for 4h, 12h, 24h, and 36h, and then analyzed. For viability analysis a pair of ovaries from two additional females was divided into nine fragments; one fragment was immediately destined for viability analysis (Trypan blue test and the other fragments were stored as previously described, until 24h and then analyzed. After 4h storage in ACP(r medium, the follicular integrity was similar to control (87.8% vs 94.4%, respectively; however, ultrastructural analyses revealed swollen mitochondria as the first signals of PF degeneration. It was observed that ACP(r (66.7% was more efficient than PBS (49.4% to preserve the morphological integrity after 36h storage (P0.05. In conclusion, the use of the ACP(r is recommended for the short-term preservation of Pecari tajacu preantral follicles.

  6. Biochemical and Structural Characterization of Germicidin Synthase: Analysis of a Type III Polyketide Synthase That Employs Acyl-ACP as a Starter Unit Donor

    Energy Technology Data Exchange (ETDEWEB)

    Chemler, Joseph A.; Buchholz, Tonia J.; Geders, Todd W.; Akey, David L.; Rath, Christopher M.; Chlipala, George E.; Smith, Janet L.; Sherman, David H. (Michigan)

    2012-08-10

    Germicidin synthase (Gcs) from Streptomyces coelicolor is a type III polyketide synthase (PKS) with broad substrate flexibility for acyl groups linked through a thioester bond to either coenzyme A (CoA) or acyl carrier protein (ACP). Germicidin synthesis was reconstituted in vitro by coupling Gcs with fatty acid biosynthesis. Since Gcs has broad substrate flexibility, we directly compared the kinetic properties of Gcs with both acyl-ACP and acyl-CoA. The catalytic efficiency of Gcs for acyl-ACP was 10-fold higher than for acyl-CoA, suggesting a strong preference toward carrier protein starter unit transfer. The 2.9 {angstrom} germicidin synthase crystal structure revealed canonical type III PKS architecture along with an unusual helical bundle of unknown function that appears to extend the dimerization interface. A pair of arginine residues adjacent to the active site affect catalytic activity but not ACP binding. This investigation provides new and surprising information about the interactions between type III PKSs and ACPs that will facilitate the construction of engineered systems for production of novel polyketides.

  7. 7 CFR 760.818 - Marketing contracts.

    Science.gov (United States)

    2010-01-01

    ... believe the participant lacks the capacity or history to fulfill the quality provisions of the marketing... 7 Agriculture 7 2010-01-01 2010-01-01 false Marketing contracts. 760.818 Section 760.818... AGRICULTURE SPECIAL PROGRAMS INDEMNITY PAYMENT PROGRAMS 2005-2007 Crop Disaster Program § 760.818 Marketing...

  8. Contingency Contracting Customer Guide

    Science.gov (United States)

    1996-12-01

    deployed contracting officer to train individual customers on the process, the customer support guide provides the necessary explanations without...straining valuable manpower resources. The Contracting Deployment Customer Guide aids the customer in contingency situations and addresses purchase requests

  9. Contractibility of curves

    Directory of Open Access Journals (Sweden)

    Janusz Charatonik

    1991-11-01

    Full Text Available Results concerning contractibility of curves (equivalently: of dendroids are collected and discussed in the paper. Interrelations tetween various conditions which are either sufficient or necessary for a curve to be contractible are studied.

  10. In silico analysis and modeling of ACP-MIP-PilQ chimeric antigen from Neisseria meningitidis serogroup B.

    Science.gov (United States)

    Gholami, Mehrdad; Salimi Chirani, Alireza; Moshiri, Mona; Sedighi, Mansour; Pournajaf, Abazar; Tohidfar, Masoud; Irajian, Gholamreza

    2015-10-01

    Neisseria meningitidis, a life-threatening human pathogen with the potential to cause large epidemics, can be isolated from the nasopharynx of 5-15% of adults. The aim of the current study was to evaluate biophysical and biochemical properties and immunological aspects of chimeric acyl-carrier protein-macrophage infectivity potentiator protein-type IV pilus biogenesis protein antigen (ACP-MIP-PilQ) from N. meningitidis serogroup B strain. Biochemical properties and multiple alignments were predicted by appropriate web servers. Secondary molecular structures were predicted based on Chou and Fasman, Garnier-Osguthorpe-Robson, and Neural Network methods. Tertiary modeling elucidated conformational properties of the chimeric protein. Proteasome cleavage and transporter associated with antigen processing (TAP) binding sites, and T- and B-cell antigenic epitopes, were predicted using bioinformatic web servers. Based on our in silico and immunoinformatics analyses, the ACP-MIP-PilQ protein (AMP) can induce high-level cross-strain bactericidal activity. In addition, several immune proteasomal cleavage sites were detected. The 22 epitopes associated with MHC class I and class II (DR) alleles were confirmed in the AMP. Thirty linear B-cell epitopes as antigenic regions were predicted from the full-length protein. All predicted properties of the AMP indicate it could be a good candidate for further immunological in vitro and in vivo studies.

  11. In silico Analysis and Modeling of ACP-MIP–PilQ Chimeric Antigen from Neisseria meningitidis Serogroup B

    Directory of Open Access Journals (Sweden)

    Mehrdad Gholami

    2015-10-01

    Full Text Available Background: Neisseria meningitidis, a life-threatening human pathogen with the potential to cause large epidemics, can be isolated from the nasopharynx of 5–15% of adults. The aim of the current study was to evaluate biophysical and biochemical properties and immunological aspects of chimeric acyl-carrier protein-macrophage infectivity potentiator protein-type IV pilus biogenesis protein antigen (ACP-MIP-PilQ from N. meningitidis serogroup B strain. Methods: Biochemical properties and multiple alignments were predicted by appropriate web servers. Secondary molecular structures were predicted based on Chou and Fasman, Garnier-Osguthorpe-Robson, and Neural Network methods. Tertiary modeling elucidated conformational properties of the chimeric protein. Proteasome cleavage and transporter associated with antigen processing (TAP binding sites, and T- and B-cell antigenic epitopes, were predicted using bioinformatic web servers. Results: Based on our in silico and immunoinformatics analyses, the ACP-MIP-PilQ protein (AMP can induce high-level cross-strain bactericidal activity. In addition, several immune proteasomal cleavage sites were detected. The 22 epitopes associated with MHC class I and class II (DR alleles were confirmed in the AMP. Thirty linear B-cell epitopes as antigenic regions were predicted from the full-length protein. Conclusion: All predicted properties of the AMP indicate it could be a good candidate for further immunological in vitro and in vivo studies.

  12. In silico analysis and modeling of ACP-MIP–PilQ chimeric antigen from Neisseria meningitidis serogroup B

    Science.gov (United States)

    Gholami, Mehrdad; Salimi Chirani, Alireza; Moshiri, Mona; Sedighi, Mansour; Pournajaf, Abazar; Tohidfar, Masoud; Irajian, Gholamreza

    2015-01-01

    Background: Neisseria meningitidis, a life-threatening human pathogen with the potential to cause large epidemics, can be isolated from the nasopharynx of 5–15% of adults. The aim of the current study was to evaluate biophysical and biochemical properties and immunological aspects of chimeric acyl-carrier protein-macrophage infectivity potentiator protein-type IV pilus biogenesis protein antigen (ACP-MIP-PilQ) from N. meningitidis serogroup B strain. Methods: Biochemical properties and multiple alignments were predicted by appropriate web servers. Secondary molecular structures were predicted based on Chou and Fasman, Garnier-Osguthorpe-Robson, and Neural Network methods. Tertiary modeling elucidated conformational properties of the chimeric protein. Proteasome cleavage and transporter associated with antigen processing (TAP) binding sites, and T- and B-cell antigenic epitopes, were predicted using bioinformatic web servers. Results: Based on our in silico and immunoinformatics analyses, the ACP-MIP-PilQ protein (AMP) can induce high-level cross-strain bactericidal activity. In addition, several immune proteasomal cleavage sites were detected. The 22 epitopes associated with MHC class I and class II (DR) alleles were confirmed in the AMP. Thirty linear B-cell epitopes as antigenic regions were predicted from the full-length protein. Conclusion: All predicted properties of the AMP indicate it could be a good candidate for further immunological in vitro and in vivo studies. PMID:26989750

  13. Enamel properties after tooth bleaching with hydrogen/carbamide peroxides in association with a CPP-ACP paste.

    Science.gov (United States)

    de Vasconcelos, Adriana Alcantara Meira; Cunha, Ana Gabriela Gama; Borges, Boniek Castillo Dutra; Vitoriano, Jussier de Oliveira; Alves-Júnior, Clodomiro; Machado, Cláudia Tavares; dos Santos, Alex José Souza

    2012-07-01

    This study evaluated the impact of bleaching teeth using blends of a CPP-ACP paste (MI Paste; MI) and carbamide/hydrogen peroxides in different proportions on surface properties of bleached enamel. Ninety bovine incisors were bleached with 7.5% hydrogen peroxide (HP), 16% carbamide peroxide (CP), MI and blends of HP or CP:MI at three proportions (1:1, 2:1, 1:2). Hardness and roughness were measured at baseline and after bleaching. Enamel morphology was evaluated by Scanning Electron Microscopy (SEM). The data were analyzed by two-way ANOVA for repeated measurements and Tukey's test. Most of the samples bleached with MI in combination with peroxides presented increased hardness and roughness which were associated to mineral deposition, as observed by SEM images. Blends with higher fractions of MI did not offer superior benefits. The use of a CPP-ACP paste mixed to carbamide/hydrogen peroxides can decrease adverse side-effects from tooth bleaching on an enamel surface.

  14. Synthesis and Characterization of New Amino Acid-Schiff Bases and Studies their Effects on the Activity of ACP, PAP and NPA Enzymes (In Vitro

    Directory of Open Access Journals (Sweden)

    Zahraa Salim M. Al-Garawi

    2012-01-01

    Full Text Available In this study, two new Schiff base compounds derived from the condensation reaction of L-glycine and L-tryptophan with 4-methylbenzal-dehyde have been synthesized. The Schiff base compounds were characterized by FT-IR, UV and 1H NMR spectroscopy. Their effects on the activity of total (ACP, prostatic (PAP and non prostatic (NPA acid phosphatase enzymes were studied. The Schiff base derived from L-glycine (A demonstrated inhibition effect on the ACP and NPA activities and activation effect on PAP activity. The Schiff base derived from L-tryptophan (B demonstrated semi fixed inhibition effects on the ACP and NPA activities at high concentrations (5.5×10-2, 5.5×10-3 and 5.5×10-4 M and activator effect at low concentration (5.5×10-5 M while it was exhibits as activator on PAP activity.

  15. 24 CFR 886.310 - Initial contract rents.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Initial contract rents. 886.310... Assistance Program for the Disposition of HUD-Owned Projects § 886.310 Initial contract rents. HUD will establish contract rents at levels that, together with other resources available to the purchasers, provide...

  16. 48 CFR 922.103-5 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 922.103... PROGRAMS APPLICATION OF LABOR LAWS TO GOVERNMENT ACQUISITION Basic Labor Policies 922.103-5 Contract clauses. In accordance with FAR 22.101-1(e) and FAR 22.103-5, the contracting officer shall insert the...

  17. Changes in the Concentration of Ions in Saliva and Dental Plaque after Application of CPP-ACP with and without Fluoride among 6-9 Year Old Children

    Directory of Open Access Journals (Sweden)

    Poureslami H

    2017-03-01

    Full Text Available Statement of Problem: The casein phospho peptide-amorphous calcium phosphate with or without fluoride (CPP-ACPF and CPP-ACP respectively are of considerably new materials which are highly recommended for prevention of dental caries. However, there is a shortage in literature on how they affect the ion concentration of saliva or dental plaque. Objectives: The aim of this study was to evaluate the concentration of calcium, phosphate and fluoride in the plaque and saliva of children with Early Childhood Caries (ECC after applying the CPP-ACP paste in comparison with the use of CPP- ACPF paste. Materials and Methods: One ml of un-stimulated saliva of 25 preschool children was collected and then 1 mg of the plaque sample was collected from the buccal surfaces of the two first primary molars on the upper jaw. CPP-ACP as well as CPP- ACPF pastes were applied on the tooth surfaces in two separate steps. In steps, plaque and saliva sampling was performed after 60 minutes. The amount of calcium ions was measured by Atomic Absorption Device and the amount of phosphate and fluoride ions was measured by Ion Chromatography instrument. Data were analyzed using Repeated Measurements ANOVA at a p < 0.05 level of significance. Results: Application of both CPP-ACPF and CPP-ACP significantly increased the concentration of calcium, phosphate, and fluoride in both saliva and dental plaque. Moreover, significantly higher salivary fluoride concentration was seen after application of CPP-ACPF compared to CPP-ACP. No other significant difference was observed between these two materials. Conclusions: CPP-ACPF can be more useful than CPP-ACP in protecting the primary teeth against caries process, especially when there is poor hygiene.

  18. Uso do diluente água de coco em pó (ACP-103® na conservação prolongada do sêmen do varrão: avaliação in vitro e in vivo Use of powder coconut water as extender (ACP-103® for boar semen longer preservation: in vitro and in vivo evaluations

    Directory of Open Access Journals (Sweden)

    R. Toniolli

    2010-10-01

    Full Text Available O sêmen de oito reprodutores foi coletado e de cada ejaculado separou-se um total de 1,75x10(9sptz, com concentração de 35x10(6sptz/mL. Usou-se o Beltsville Thawing Solution (BTS como controle para testar o diluente água de coco em pó (ACP. O dia de coleta foi o dia zero (D0, sendo o sêmen conservado durante cinco dias, com análises diárias no D0 e nos quatro dias seguintes (D1, D2, D3 e D4. A avaliação da qualidade espermática baseou-se nos resultados do vigor espermático, da porcentagem de células móveis, da morfologia espermática, da integridade da membrana plasmática e dos resultados de fertilidade. As avaliações do vigor espermático (4,1 e da porcentagem de espermatozoides móveis (91% ficaram acima dos parâmetros mínimos exigidos (3,0 e 70% para sua utilização em programas de inseminação artificial, pois não houve influência sobre as variáveis analisadas pelo protocolo experimental. O resultado médio da resistência osmótica foi de 71,3% de espermatozoides com cauda enrolada. Não houve diferenças entre os dois diluentes testados para a característica células com acrossoma intacto (BTS = 67,1%; ACP = 71,2%. O sêmen diluído em ACP apresentou maior número de células vivas (77,7 % com membrana plasmática íntegra (74,2% após a conservação. A escolha do diluente ACP é aconselhável para uso de rotina em laboratórios que trabalhem com conservação de sêmen suíno. Apesar dos bons resultados in vitro obtidos com o diluente ACP, o BTS apresentou os melhores resultados de fertilidade, 86,7% e 96,7%, respectivamente.The semen of eight boars was collected and a total of 1.75x10(9 spermatozoa were separated from each ejaculate, obtaining a concentration of 35x10(6sptz/mL. The Beltsville Thawing Solution (BTS was used as control, being tested the powder coconut water as extender (PCW. The day of collection was considered day zero (D0, and the semen was conserved for five days, with analyses on D0 and on

  19. Contracting for Public Services

    DEFF Research Database (Denmark)

    Greve, Carsten

    strategic purchasing understanding markets communicating the contracting decision designing and drafting the contract the role of the consumer the regulation of service provision Illustrated throughout with practitioner case-studies from a range of OECD countries, this book presents an important new...... theoretical ‘contract management model' and a ‘mature contract model', and explores the mechanisms, formal rules and informal norms that influence the way governments contract for public services. This book is essential reading for all students of public management and all public service managers....

  20. Combined BTK and PI3Kδ inhibition with acalabrutinib and ACP-319 improves survival and tumor control in CLL mouse model

    DEFF Research Database (Denmark)

    Niemann, Carsten U; Mora-Jensen, Helena I; Dadashian, Eman L

    2017-01-01

    the effectiveness of combing PI3K-delta and BTK inhibitors. Experimental design: As CLL proliferation and survival depends on the microenvironment, we used murine models to assess the efficacy of the BTK inhibitor acalabrutinib combined with the PI3K-delta inhibitor ACP-319 in vivo We compared single......, combination therapy extended survival by over two weeks compared to either single agent. The combination reduced tumor proliferation, NF-KB signaling and expression of BCL-xL and MCL-1 more potently than single-agent therapy. Conclusion: The combination of acalabrutinib and ACP-319 was superior...

  1. Contracts in distributed systems

    Directory of Open Access Journals (Sweden)

    Massimo Bartoletti

    2011-07-01

    Full Text Available We present a parametric calculus for contract-based computing in distributed systems. By abstracting from the actual contract language, our calculus generalises both the contracts-as-processes and contracts-as-formulae paradigms. The calculus features primitives for advertising contracts, for reaching agreements, and for querying the fulfilment of contracts. Coordination among principals happens via multi-party sessions, which are created once agreements are reached. We present two instances of our calculus, by modelling contracts as (i processes in a variant of CCS, and (ii as formulae in a logic. With the help of a few examples, we discuss the primitives of our calculus, as well as some possible variants.

  2. Campylobacter jejuni fatty acid synthase II: Structural and functional analysis of [beta]-hydroxyacyl-ACP dehydratase (FabZ)

    Energy Technology Data Exchange (ETDEWEB)

    Kirkpatrick, Andrew S.; Yokoyama, Takeshi; Choi, Kyoung-Jae; Yeo, Hye-Jeong; (Houston)

    2009-08-14

    Fatty acid biosynthesis is crucial for all living cells. In contrast to higher organisms, bacteria use a type II fatty acid synthase (FAS II) composed of a series of individual proteins, making FAS II enzymes excellent targets for antibiotics discovery. The {beta}-hydroxyacyl-ACP dehydratase (FabZ) catalyzes an essential step in the FAS II pathway. Here, we report the structure of Campylobacter jejuni FabZ (CjFabZ), showing a hexamer both in crystals and solution, with each protomer adopting the characteristic hot dog fold. Together with biochemical analysis of CjFabZ, we define the first functional FAS II enzyme from this pathogen, and provide a framework for investigation on roles of FAS II in C. jejuni virulence

  3. Cloning of acyl-ACP thioesterase FatA from Arachis hypogaea L. and its expression in Escherichia coli.

    Science.gov (United States)

    Chen, Gao; Peng, Zhen-ying; Shan, Lei; Xuan, Ning; Tang, Gui-ying; Zhang, Yan; Li, Lan; He, Qing-fang; Bi, Yu-ping

    2012-01-01

    In this study, a full-length cDNA of the acyl-ACP thioesterase, AhFatA, was cloned from developing seeds of Arachis hypogaea L. by 3'-RACE. Sequence analysis showed that the open reading frame encodes a peptide of 372 amino acids and has 50-70% identity with FatA from other plants. Real-time quantitative PCR analysis revealed that AhFatA was expressed in all tissues of A. hypogaea L., but most strongly in the immature seeds harvested at 60 days after pegging. Heterologous expression of AhFatA in Escherichia coli affected bacterial growth and changed the fatty acid profiles of the membrane lipid, resulting in directed accumulation towards palmitoleic acid and oleic acid. These results indicate that AhFatA is at least partially responsible for determining the high palmitoleic acid and oleic acid composition of E. coli.

  4. Cloning of Acyl-ACP Thioesterase FatA from Arachis hypogaea L. and Its Expression in Escherichia coli

    Directory of Open Access Journals (Sweden)

    Gao Chen

    2012-01-01

    Full Text Available In this study, a full-length cDNA of the acyl-ACP thioesterase, AhFatA, was cloned from developing seeds of Arachis hypogaea L. by 3′-RACE. Sequence analysis showed that the open reading frame encodes a peptide of 372 amino acids and has 50–70% identity with FatA from other plants. Real-time quantitative PCR analysis revealed that AhFatA was expressed in all tissues of A. hypogaea L., but most strongly in the immature seeds harvested at 60 days after pegging. Heterologous expression of AhFatA in Escherichia coli affected bacterial growth and changed the fatty acid profiles of the membrane lipid, resulting in directed accumulation towards palmitoleic acid and oleic acid. These results indicate that AhFatA is at least partially responsible for determining the high palmitoleic acid and oleic acid composition of E. coli.

  5. New staff contract policy

    CERN Multimedia

    HR Department

    2006-01-01

    Following discussion at TREF and on the recommendation of the Finance Committee, Council approved a new staff contract policy, which became effective on 1 January 2006. Its application is covered by a new Administrative Circular No. 2 (Rev. 3) 'Recruitment, appointment and possible developments regarding the contractual position of staff members'. The revised circular replaces the previous Circulars No. 9 (Rev. 3) 'Staff contracts' and No. 2 (Rev. 2) 'Guidelines and procedures concerning recruitment and probation period for staff members'. The main features of the new contract policy are as follows: The new policy provides chances for long-term employment for all staff recruits staying for four years without distinguishing between those assigned to long-term or short-term activities when joining CERN. In addition, it presents a number of simplifications for the award of ICs. There are henceforth only 2 types of contract: Limited Duration (LD) contracts for all recruitment and Indefinite Contracts (IC) for...

  6. SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function.

    Science.gov (United States)

    Li, Man; Li, Yong; Weeks, Olivia; Mijatovic, Vladan; Teumer, Alexander; Huffman, Jennifer E; Tromp, Gerard; Fuchsberger, Christian; Gorski, Mathias; Lyytikäinen, Leo-Pekka; Nutile, Teresa; Sedaghat, Sanaz; Sorice, Rossella; Tin, Adrienne; Yang, Qiong; Ahluwalia, Tarunveer S; Arking, Dan E; Bihlmeyer, Nathan A; Böger, Carsten A; Carroll, Robert J; Chasman, Daniel I; Cornelis, Marilyn C; Dehghan, Abbas; Faul, Jessica D; Feitosa, Mary F; Gambaro, Giovanni; Gasparini, Paolo; Giulianini, Franco; Heid, Iris; Huang, Jinyan; Imboden, Medea; Jackson, Anne U; Jeff, Janina; Jhun, Min A; Katz, Ronit; Kifley, Annette; Kilpeläinen, Tuomas O; Kumar, Ashish; Laakso, Markku; Li-Gao, Ruifang; Lohman, Kurt; Lu, Yingchang; Mägi, Reedik; Malerba, Giovanni; Mihailov, Evelin; Mohlke, Karen L; Mook-Kanamori, Dennis O; Robino, Antonietta; Ruderfer, Douglas; Salvi, Erika; Schick, Ursula M; Schulz, Christina-Alexandra; Smith, Albert V; Smith, Jennifer A; Traglia, Michela; Yerges-Armstrong, Laura M; Zhao, Wei; Goodarzi, Mark O; Kraja, Aldi T; Liu, Chunyu; Wessel, Jennifer; Boerwinkle, Eric; Borecki, Ingrid B; Bork-Jensen, Jette; Bottinger, Erwin P; Braga, Daniele; Brandslund, Ivan; Brody, Jennifer A; Campbell, Archie; Carey, David J; Christensen, Cramer; Coresh, Josef; Crook, Errol; Curhan, Gary C; Cusi, Daniele; de Boer, Ian H; de Vries, Aiko P J; Denny, Joshua C; Devuyst, Olivier; Dreisbach, Albert W; Endlich, Karlhans; Esko, Tõnu; Franco, Oscar H; Fulop, Tibor; Gerhard, Glenn S; Glümer, Charlotte; Gottesman, Omri; Grarup, Niels; Gudnason, Vilmundur; Hansen, Torben; Harris, Tamara B; Hayward, Caroline; Hocking, Lynne; Hofman, Albert; Hu, Frank B; Husemoen, Lise Lotte N; Jackson, Rebecca D; Jørgensen, Torben; Jørgensen, Marit E; Kähönen, Mika; Kardia, Sharon L R; König, Wolfgang; Kooperberg, Charles; Kriebel, Jennifer; Launer, Lenore J; Lauritzen, Torsten; Lehtimäki, Terho; Levy, Daniel; Linksted, Pamela; Linneberg, Allan; Liu, Yongmei; Loos, Ruth J F; Lupo, Antonio; Meisinger, Christine; Melander, Olle; Metspalu, Andres; Mitchell, Paul; Nauck, Matthias; Nürnberg, Peter; Orho-Melander, Marju; Parsa, Afshin; Pedersen, Oluf; Peters, Annette; Peters, Ulrike; Polasek, Ozren; Porteous, David; Probst-Hensch, Nicole M; Psaty, Bruce M; Qi, Lu; Raitakari, Olli T; Reiner, Alex P; Rettig, Rainer; Ridker, Paul M; Rivadeneira, Fernando; Rossouw, Jacques E; Schmidt, Frank; Siscovick, David; Soranzo, Nicole; Strauch, Konstantin; Toniolo, Daniela; Turner, Stephen T; Uitterlinden, André G; Ulivi, Sheila; Velayutham, Dinesh; Völker, Uwe; Völzke, Henry; Waldenberger, Melanie; Wang, Jie Jin; Weir, David R; Witte, Daniel; Kuivaniemi, Helena; Fox, Caroline S; Franceschini, Nora; Goessling, Wolfram; Köttgen, Anna; Chu, Audrey Y

    2017-03-01

    Genome-wide association studies have identified >50 common variants associated with kidney function, but these variants do not fully explain the variation in eGFR. We performed a two-stage meta-analysis of associations between genotypes from the Illumina exome array and eGFR on the basis of serum creatinine (eGFRcrea) among participants of European ancestry from the CKDGen Consortium (nStage1: 111,666; nStage2: 48,343). In single-variant analyses, we identified single nucleotide polymorphisms at seven new loci associated with eGFRcrea (PPM1J, EDEM3, ACP1, SPEG, EYA4, CYP1A1, and ATXN2L; PStage1<3.7×10-7), of which most were common and annotated as nonsynonymous variants. Gene-based analysis identified associations of functional rare variants in three genes with eGFRcrea, including a novel association with the SOS Ras/Rho guanine nucleotide exchange factor 2 gene, SOS2 (P=5.4×10-8 by sequence kernel association test). Experimental follow-up in zebrafish embryos revealed changes in glomerular gene expression and renal tubule morphology in the embryonic kidney of acp1- and sos2-knockdowns. These developmental abnormalities associated with altered blood clearance rate and heightened prevalence of edema. This study expands the number of loci associated with kidney function and identifies novel genes with potential roles in kidney formation. Copyright © 2017 by the American Society of Nephrology.

  7. An analysis of the training and development of the contract specialist 1102 interns

    OpenAIRE

    Jones, Pamela; Pettygrue, Valerie

    2010-01-01

    Joint Applied Project This thesis analyzed the U.S. Army Contracting Command (ACC) training and development programs for contract specialists (1102s). Involvement in two wars has generated unintended consequences in the contracting community, which may be adversely affecting the Army's ability to meet and sustain its contracting responsibilities, e.g., an expanding contracting mission accompanied by substantial attrition of experienced contracting professionals. The study analyzed 11...

  8. CRIOPRESERVAÇÃO DO SÊMEN OVINO EM MEIO DILUENTE À BASE DE ÁGUA DE COCO EM PÓ (ACP-102C

    Directory of Open Access Journals (Sweden)

    José Maurício Maciel Cavalcante

    2014-09-01

    Full Text Available The aim of this study was to evaluate the ACP-102c extender in the cryopreservation of ram semen compared to tris-glucose-egg yolk (TRIS extender and fresh semen. Forty-eight ejaculates were collected from four rams and two aliquots per ejaculate were taken for dilution and cryopreservation in ACP-102c or TRIS and a third aliquot used for the fresh semen analysis. Either the fresh semen and cryopreserved in both extenders were evaluated for viability, integrity of plasma and acrosomal membrane, hypoosmotic swelling test, DNA fragmentation and sperm motility. The extenders did not differ for sperm viability, acrosome and plasma membrane integrity, DNA fragmentation and quantitative and qualitative parameters of sperm velocity after thawing, but differed in hypoosmotic swelling test, total and progressive motility and lateral extent of the head as well as in all motility parameters evaluated (except linearity and straightness after two hours of incubation at 37 oC. There was variability among rams in total and progressive motility of semen cryopreserved in ACP-102c after thawing. The ACP-102c extender showed less protection in the cryopreservation of ram sperm when compared to TRIS, but the improvement in its formulation and freezing protocols may make it an alternative to freezing ram semen.

  9. Contracting in crisis intervention.

    Science.gov (United States)

    Nelson, Z P; Mowry, D D

    1976-01-01

    The use of contracts in the social services is an important area that needs to be looked at. This paper is concerned specifically with the use of contracts in one particular part of social services: crisis intervention. Contracts that define the working relationship between the client and mental health counselor can be beneficial for both when they attempt to solve the problems that contributed to the crisis situation. There are five benefits to be gained from the use of contracts in crisis intervention and they are briefly discussed.

  10. Smart contracts sobre Bitcoin

    OpenAIRE

    Andreu Alemany, Josep Miquel

    2016-01-01

    El present treball final de màster realitza una introducció als smart contracts. El treball introdueix el concepte de contracte intel·ligent, els seus usos i alguns exemples existents. Seguidament proporciona les nocions necessàries de les transaccions del protocol Bitcoin per poder implementar un contracte intel·ligent, usant la blockchain que ofereix el protocol. Per últim, s'explica la implementació d'un contracte intel·ligent usant bitcoin: un canal de micropagaments. El presente traba...

  11. A Module Language for Typing by Contracts

    Science.gov (United States)

    Glouche, Yann; Talpin, Jean-Pierre; LeGuernic, Paul; Gautier, Thierry

    2009-01-01

    Assume-guarantee reasoning is a popular and expressive paradigm for modular and compositional specification of programs. It is becoming a fundamental concept in some computer-aided design tools for embedded system design. In this paper, we elaborate foundations for contract-based embedded system design by proposing a general-purpose module language based on a Boolean algebra allowing to define contracts. In this framework, contracts are used to negotiate the correctness of assumptions made on the definition of a component at the point where it is used and provides guarantees to its environment. We illustrate this presentation with the specification of a simplified 4-stroke engine model.

  12. Forward genetic screen in Caenorhabditis elegans suggests F57A10.2 and acp-4 as suppressors of C9ORF72 related phenotypes

    Directory of Open Access Journals (Sweden)

    XIN WANG

    2016-11-01

    Full Text Available An abnormally expanded GGGGCC repeat in C9ORF72 is the most frequent causal mutation associated with amyotrophic lateral sclerosis (ALS frontotemporal lobar degeneration (FTLD. Both gain-of-function (gf and loss-of-function (lf mechanisms have been involved in C9ORF72 related ALS FTLD. The gf mechanism of C9ORF72 has been studied in various animal models but not in C. elegans. In the present study, we described mutant C9ORF72 modeling in C. elegans and report the finding of two suppressor genes.We made transgenes containing 9 or 29 repeats of GGGGCC in C9ORF72, driven by either the hsp-16 promoters or the unc 119 promoter.Transgenic worms were made to carry such transgenes.Phenotypic analysis of those animals revealed that Phsp 16::(G4C229::GFP transgenic animals (EAB 135 displayed severe paralysis by the second day of adulthood, followed by lethality, which phenotypes were less severe in Phsp 16::(G4C29::GFP transgenic animals (EAB242,and absent in control strains expressing empty vectors. Suppressor genes of this locomotor phenotype were pursued by introducing mutations with ethyl methanesulfonate in EAB135, screening mutant strains that moved faster than EAB135 by a food-ring assay, identifying mutations by whole-genome sequencing and testing the underlying mechanism of the suppressor genes either by employing RNA interference studies or C. elegans genetics. Three mutant strains, EAB164, EAB165 and EAB167, were identified. Eight suppressor genes carrying nonsense canonical splicing site mutations were confirmed, among which a nonsense mutation of F57A10.2 VAMP was found in all three mutant strains, and a nonsense mutation of acp-4 ACP2 was only found in EAB164. Knock down out of those two genes in EAB135 animals by feeding RNAi introducing a known acp-4 null allele phenocopied the suppression of the C9ORF72 variant related movement defect in the mutant strains. Translational conformation in a mammalian system is required, but our worm data

  13. 75 FR 18034 - Defense Federal Acquisition Regulation Supplement; Research and Development Contract Type...

    Science.gov (United States)

    2010-04-08

    ... Regulation Supplement; Research and Development Contract Type Determination (DFARS Case 2006-D053) AGENCY... a major defense acquisition program (MDAP) to select the contract type for a development program... requires DoD to modify regulations regarding the determination of contract type for development programs...

  14. Avaliação de espermatozoides caprinos congelados em meio à base de água de coco em pó (ACP-101® ou TRIS

    Directory of Open Access Journals (Sweden)

    R.V. Oliveira

    2011-12-01

    Full Text Available Compararam-se as características cinéticas e morfológicas de espermatozoides caprinos congelados nos meios à base de ACP-101® e TRIS. Os diluentes utilizados foram: ACP-101® (+ 2,5% gema ovo + 7% glicerol e TRIS (+ 20% gema ovo + 6,8% glicerol. Quarenta e oito ejaculados de quatro bodes foram coletados, avaliados, divididos em duas alíquotas e diluídos nos meios ACP-101® e TRIS, respectivamente, posteriormente congelados e, após 30 dias, descongelados. A avaliação da motilidade espermática por computador foi realizada aos 5, 60 e 120 minutos pós-descongelação. As características de motilidade espermática analisadas foram: motilidade total (MT (% e progressiva (MP (%, velocidades média do trajeto do espermatozoide (VAP (µm/s e linear (VSL (µm/s e população de espermatozoides rápidos (ER (%. As avaliações de morfologia espermática quantificaram a porcentagem de espermatozoides normais (N e as alterações da cabeça (AC, da peça intermediária (API e do flagelo (AF, aos cinco e 120 minutos pós-descongelação. O diluente TRIS apresentou resultados cinéticos mais elevados que o ACP-101® aos 60 e 120 minutos pós-descongelação. As AC aos 120 minutos pós-descongelação foram mais altas nos espermatozoides congelados em ACP-101®. Conclui-se que o diluente TRIS promoveu maior viabilidade in vitro dos espermatozoides caprinos pós-descongelação.

  15. Evaluation of metallic brackets adhesion after the use of bleaching gels with and without amorphous calcium phosphate (ACP: in vitro study

    Directory of Open Access Journals (Sweden)

    Sissy Maria Mendes Machado

    2013-06-01

    Full Text Available OBJECTIVE: To evaluate in vitro the effects of tooth whitening using gel with Amorphous Calcium Phosphate (ACP on the bond strength of metal brackets. METHODS: Thirty-six bovine incisors were sectioned at the crown-root interface, and the crowns were then placed in PVC cylinders. The specimens were divided into 3 groups (n = 12 according to whitening treatment and type of gel used, as follows: G1 (control = no whitening; G2 = whitening with gel not containing ACP (Whiteness Perfect - FGM, G3 = whitening with gel containing ACP (Nite White ACP - Discus Dental. Groups G2 and G3 were subjected to 14 cycles of whitening followed by an interval of 15 days before the bonding of metal brackets. Shear bond strength testing was performed on a Kratos universal test machine at a speed of 0.5 mm/min. After the mechanical test, the specimens were assessed to determine the adhesive remnant index (ARI. The results were subjected to ANOVA, Tukey's test and Kruskal-Wallis test (5%. RESULTS: Significant differences were noted between the groups. Control group (G1 = 11.10 MPa showed a statistically higher shear bond strength than the groups that underwent whitening (G2 = 5.40 Mpa, G3 = 3.73 MPa, which did not differ from each other. There were no significant differences between the groups in terms of ARI. CONCLUSION: Tooth whitening reduces the bond strength of metal brackets, whereas the presence of ACP in the whitening gel has no bearing on the results.

  16. 7 CFR 1416.202 - Eligible owners and contract growers.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Eligible owners and contract growers. 1416.202... DISASTER ASSISTANCE PROGRAMS Livestock Indemnity Program II § 1416.202 Eligible owners and contract growers. (a) To be considered eligible, a livestock owner must have had legal ownership of the eligible...

  17. 48 CFR 42.302 - Contract administration functions.

    Science.gov (United States)

    2010-10-01

    ... schedules. (32) Perform preaward surveys (see Subpart 9.1). (33) Advise and assist contractors regarding... awareness program (see subpart 23.5). (67) Support the program, product, and project offices regarding...) Monitor the contractor's environmental practices for adverse impact on contract performance or contract...

  18. Training by Contract: Models of Success between Colleges and Employers.

    Science.gov (United States)

    College Entrance Examination Board, New York, NY.

    This book offers colleges and universities information on contract training with business and industry, suggesting ways to blend corporate education programs into the organizational structure of both the educational institution and the business organization, and providing guidelines for obtaining contracts and delivering programs. Included also…

  19. Contracting out local services

    DEFF Research Database (Denmark)

    Petersen, Ole Helby; Houlberg, Kurt; Ring Christensen, Lasse

    2015-01-01

    Governments face a fundamental choice between in-house production and contracting out for the delivery of services to citizens. This article examines the importance of ideology, fiscal pressure, and size for contracting out in technical and social services. The analysis builds on a panel data set...... that the size effect is contingent on the transaction cost characteristics of the service....

  20. Gas contracts in transition

    Energy Technology Data Exchange (ETDEWEB)

    Wright, A.J. [Delhi Gas Pipeline Corp., Dallas, TX (United States)

    1992-12-31

    The transition of gas marketing by producers from a regulated and structured market to an open competitive and commodity market has created new challenges for attorneys drafting gas sales contracts. This article examines the following related topics: Interruptible contracts; pricing provisions; transport imbalances.

  1. BOT Outsourcing Contracts

    DEFF Research Database (Denmark)

    Ørberg Jensen, Peter D.; Petersen, Bent

    2012-01-01

    -firm linkages) and develop three scenarios for the implications for vendor firms. We find that BOT contracts, under certain circumstances, may imply benefits of process and knowledge upgrading for the emerging market vendor firm. However, given different sets of circumstances, engaging in a BOT contract carries...

  2. Partnering and contracting

    DEFF Research Database (Denmark)

    Bohnstedt, Kristian Ditlev

    2014-01-01

    Purpose - Partnering is often, by economists, and construction managerial literature related to more incomplete contracts. This can be explained by seeing partnering as something that neutralizes opportunism. The aim is to uncover whether partnering neutralizes opportunism when there is an incomp......Purpose - Partnering is often, by economists, and construction managerial literature related to more incomplete contracts. This can be explained by seeing partnering as something that neutralizes opportunism. The aim is to uncover whether partnering neutralizes opportunism when...... there is an incomplete contract or reduces transaction costs for renegotiation of complete contracts when new information arises. Design - The study is a cross-sectional design comprising document analysis and interviews. Findings - Firstly that partnering does not necessarily entail more incomplete contracts, which...... contradicts the incomplete contracting theory. Secondly, in complete contract setting partnering can be motivated when seen as a willingness to renegotiate complete contracts i.e. partnering lowers transaction costs for renegotiation. Partnering can make it rational for one party to accept disadvantageous...

  3. Contracting for Telecommunications Systems.

    Science.gov (United States)

    Brautigam, Arthur W.

    1984-01-01

    Reasons for changing telephone systems at colleges and universities and the preparation and evaluation of requests for proposals (RFP) are discussed. The negotiation and monitoring of the contract are also addressed. It is noted that contracting for a new telecommunications system is extremely complex. Reasons for changing systems include cost…

  4. Contracting Productivity Growth

    NARCIS (Netherlands)

    Francois, P.; Roberts, J.

    2001-01-01

    In this paper, we analyze the interactions between growth and the contracting environment in the production sector.Allowing incompleteness in contracting implies that viable production relationships for firms and workers, and therefore the profitability of industries, depend on the rates of

  5. Contract Teachers in India

    Science.gov (United States)

    Goyal, Sangeeta; Pandey, Priyanka

    2013-01-01

    In this paper, we use non-experimental data from government schools in Uttar Pradesh and Madhya Pradesh, two of the largest Indian states, to present average school outcomes by contract status of teachers. We find that contract teachers are associated with higher effort than civil service teachers with permanent tenures, before as well as after…

  6. Contract Training for Industry.

    Science.gov (United States)

    Averill, Donald F.

    1983-01-01

    Describes contract training whereby industries arrange with community colleges, technical institutes, and vocational schools to prepare employees for specific job assignments. Indicates that industrial training performed under contract with public institutions should be encouraged in favor of expansion of training that industry performs for…

  7. Contribution to contract theory

    Directory of Open Access Journals (Sweden)

    Pantelić Svetlana

    2016-01-01

    Full Text Available Oliver Hart and Bengt Holmstrom share the Nobel Prize in Economic Sciences for 2016, awarded to them by Sveriges Riksbank. They have been rewarded for their work in enhancing the design of contracts, i.e. arrangements connecting employers with employees or companies with clients, in other words, for their contribution to contract theory in the 1970s and 1980s. Their analysis of optimal contractual arrangements lays an intellectual foundation for designing policies and institutions in many areas, from bankruptcy legislation to political constitutions. Hart is an expert in contract theory, theory of the firm, corporate finance, and law and economics. His contribution to contract theory is exquisite when it comes to designing contracts which cover eventualities that cannot be precisely specified in advance.

  8. Bunker purchasing with contracts

    DEFF Research Database (Denmark)

    Plum, Christian Edinger Munk; Neergaard Jensen, Peter; Pisinger, David

    2014-01-01

    constraints such as capacity limits, reserve requirements and sulphur content. Contracts are often used for bunker purchasing, ensuring supply and often giving a discounted price. A contract can supply any vessel in a period and port, and is thus a shared resource between vessels, which must be distributed...... optimally to reduce overall costs. The Bunker Purchasing with Contracts Problem has been formulated as a mixed integer programme, which has been Dantzig-Wolfe decomposed. To solve it, a novel column generation algorithm has been developed. The algorithm has been run on a series of real-world instances...... with up to 500+ vessels and 500+ contracts, and provide near optimal solutions. This makes it possible for a major liner shipping company to plan bunker purchasing on a global level, and provides an efficient tool for assessing new contracts....

  9. THE PSYCHOLOGICAL CONTRACT

    Directory of Open Access Journals (Sweden)

    Blanca Giorgiana GRAMA

    2015-04-01

    Full Text Available The psychological contract became known as a research paradigm within corporate research, providing a broad framework which explains the employee-company relations. Despite all this, there are still many debates on the concept and a series of criticism were expressed that led to the necessity of some more rigorous theoretical and empirical analysis. The psychological contract refers to the unwritten, implicit expectations that employees have from the company and vice versa; it is that which defines the things the employee expects from the employer. Consequently, each of the parties involved in the contract may have different perceptions on these commitments and obligations. Thus the psychological contract may be regarded as an exchange relation between the employer and the employee. Breaking the psychological contract affects the performance, the morale, and the motivation of the staff in a negative manner. The information presented in this paper is intended to contribute to the theoretical and methodological development of the concept.

  10. Capsule contraction syndrome

    Directory of Open Access Journals (Sweden)

    Mesut COŞKUN

    2009-06-01

    Full Text Available Capsule contraction syndrome occurs after fibrous metaplasia of lens proteins that leads to capsular bag contraction. Excessive front capsular wrinkling is seen in capsule contraction syndrome and there is an imbalance between powers supplying capsular integrity. This situation leads to zonular weakness. Capsule contraction syndrome is associated with pseudoexfoliation, older age, uveitis, pars planitis and myotonic muscular dystrophy. In order to decrease the risk of capsule contraction syndrome, front capsulerhexis area should be open as 5.5-6 mm diameter and a curysoft intraocular lens should be used. In order to prevent lens epithelial proliferation and metaplasia, lens epithelial cells at inferior surface of front capsule should be aspirated carefully. If postoperative capsular contraction detected, front capsulotomy should be performed by Nd-YAG laser at postoperative 2 to 3 weeks. In patients that Nd-YAG laser is unsuccessful, capsular tension should be decreased by surgical microincisions. In present study, we evaluated etiology, prevention and management of capsule contraction syndrome in the light of actual literature knowledge.

  11. ENFORCEMENT OF MORTGAGE CONTRACT

    Directory of Open Access Journals (Sweden)

    Alisa A. BELU

    2016-07-01

    Full Text Available A chattel mortgage contract is the expression of a real guarantee that gives the creditor precedence over other creditors, in addition to the general pledge upon the belongings of the debtor. It refers to the sale of mortgaged movable assets, exclusively or prioritized in favor of the mortgaging creditor, in case the debtor does not comply with his / her commitments, under the signed mortgage contract. Beginning from this purpose, shared by both sides (as the chattel mortgage contract is synallagmatic, in case the debtor is unable to fulfill his / her commitments, the sides reach a situation of enforcement of the signed chattel mortgage contract. Given the legal status of the chattel mortgage contract [Art. 2387-2477 Noul Cod Civil , Universul Juridic, Bucureşti, 2016, ISBN 978-606-673-792-0], the principle of binding force of the contract and the principle according to which signed legal conventions will entail legal effects, the Romanian law maker developed the proper legal framework for the enforcement of the chattel mortgage contract. [art. 622 si urm. Noul Cod de Procedură Civilă, ed. Hamangiu, Bucureşti, 2016, ISBN 978-606-27-0459-9].

  12. Army Acquisition and Contracting Personnel Requirements: How are the Army’s Current Recruitment, Development and Retention Programs Meeting Current and Future Personnel Requirements?

    Science.gov (United States)

    2011-09-01

    execution. Organizations provided responses they have or are evaluating schedule flexibility, telework policy, and voluntary civilian fitness. Engaging...alternative work schedules, implementing ACC Telework policy, relocation incentives, and management placing special emphasis on the importance of...MICC G-1 established a voluntary civilian fitness program, embraced alternative work schedules, and implemented ACC Telework policy. 103

  13. A Comparison of Two Approaches to Marital Enrichment and Conjugal Skills Training: Minnesota Couples Communication Program and Structured Behavioral Exchange Contracting.

    Science.gov (United States)

    Russell, Candyce S.; And Others

    1984-01-01

    Compared Minnesota Couples Communication Program and Structured Behavior Exchange training with a waiting list control group through a multivariate repeated measures procedure (N=32 couples). Results indicated a general short-term improvement for both groups, but a need for follow-up experiences to maintain treatment gains. (JAC)

  14. A Business Case for Home Performance Contracting

    Energy Technology Data Exchange (ETDEWEB)

    Baechler, Michael C.; Antonopoulos, Chrissi A.; Sevigny, Maureen; Gilbride, Theresa L.; Hefty, Marye G.

    2012-10-01

    This report was prepared by PNNL for the DOE Building America program. The report provides information for businesses considering entering the home performance contracting industry. Metrics discussed include industry trends and drivers, specific points of entry, business models, startup costs, and marketing strategies. The report includes detailed analysis of eight businesses around the country that have successfully entered the home performance contracting industry. Data is provided on their financial structures, program participation, marketing efforts, and staff training. This report will be distributed via the DOE Building America website, www.buildingamerica.gov. Individual case studies will also be cleared separately.

  15. Temporary labour contracts

    CERN Document Server

    1999-01-01

    The five contracts for Temporary Labour assignments on the CERN site (L020/PE, L021/PE, L022/PE, L023/PE and L024/PE) approved by the Finance Committee in March 1996 (CERN/FC/3857) will reach the end of their initial three-year contractual period at the end of December 1999. Following the satisfactory execution of these contracts during this period, CERN requests approval to extend them from January 2000 for the first of the two years foreseen in the original adjudication. The Finance Committee is invited: - to take note that the three-year expenditure for Temporary Labour contracts from 1997 to 1999 will not exceed 19 100 000 Swiss francs, compared to the 18 900 000 Swiss francs estimated at the time of the adjudication in March 1996; - to approve an extension of the present Temporary Labour contracts for the year 2000 for a total amount not exceeding 6 000 000 Swiss francs.

  16. Premature Ventricular Contractions (PVCs)

    Science.gov (United States)

    ... Premature ventricular contractions (PVCs) Symptoms & causes Diagnosis & treatment Advertisement Mayo Clinic does not endorse companies or products. ... a Job Site Map About This Site Twitter Facebook Google YouTube Pinterest Mayo Clinic is a not- ...

  17. Contracting the Facebook API

    Directory of Open Access Journals (Sweden)

    Ben Rubinger

    2010-09-01

    Full Text Available In recent years, there has been an explosive growth in the popularity of online social networks such as Facebook. In a new twist, third party developers are now able to create their own web applications which plug into Facebook and work with Facebook's "social" data, enabling the entire Facebook user base of more than 400 million active users to use such applications. These client applications can contain subtle errors that can be hard to debug if they misuse the Facebook API. In this paper we present an experience report on applying Microsoft's new code contract system for the .NET framework to the Facebook API.We wrote contracts for several classes in the Facebook API wrapper which allows Microsoft .NET developers to implement Facebook applications. We evaluated the usefulness of these contracts during implementation of a new Facebook application. Our experience indicates that having code contracts provides a better and quicker software development experience.

  18. An unsatisfactory contract policy

    CERN Multimedia

    Association du personnel

    2012-01-01

    For the last 15 years contract policy has been one of the top priorities of CERN staff, as expressed in successive surveys initiated by the Staff Association. In one’s professional life, having some forward vision of one’s career prospects is the key to loyalty and motivation. On the contrary, instability about the future is always at the root of anxiety, conflicts, or even health problems. A good employer must therefore balance the needs of the Company and those of its employees. CERN’s current contract policy, as described in the Administrative Circular No 2, states that staff members should first obtain a limited duration (LD) contract of up to five years. Then, if they want to stay in the Organization, staff members must apply, usually once a year, and before the end of their LD contract, for an indefinite contract (IC) post. All candidates for an IC post are considered by the Review Board for the award of indefinite contracts (Review Board) which will choose the most suita...

  19. [Genetic polymorphism of AcP, EsD, 6-PGD and GPT in eleven ethnic groups of China].

    Science.gov (United States)

    Xu, J J; Tan, Q A; Zhao, X X; Du, R F

    1989-01-01

    The genetic polymorphism of red cell acid phosphatase (AcP), Esterase D (EsD), 6-phosphogluconate dehydrogenase (6-PGD) and Glutamic pyruvic transaminase (GPT) in eleven ethnic groups of China was studied by starch gel electrophoresis. The results of 2272 tested showed that the gene frequencies of AcPB1 in Dong, Hui, Bai, Tujia, Miao, Yi, Tibetan, Man, Yao, Hani, Buyi, etc. were 0.7835, 0.7958, 0.8137, 0.7750, 0.7624, 0.8038, 0.8075, 0.8035, 0.7725, 0.6488, 0.6896, EsD1 gene frequencies were 0.6418, 0.7315, 0.6005, 0.6025, 0.6411, 0.6411, 0.6558, 0.6305, 0.6020, 0.6023, 0.6368. 6-PGDA gene frequencies 0.9279, 0.9381, 0.9387, 0.9150, 0.9356, 0.9014, 0.7764, 0.8818, 0.9851, 0.9233, 0.9410. GPT1 gene frequencies 0.4075, 0.5367, 0.5049, 0.4824, 0.5322, 0.6106, 0.6313, 0.6400, 0.3985, 0.4930, 0.3976, respectively. In addition, some rare variants were found.

  20. Le processus d'intégration économique des pays ACP : de la convention de Lomé à la convention de Cotonou

    OpenAIRE

    Julien Etogo

    2001-01-01

    L’Accord de Cotonou, signé le 23 juin 2000, pour favoriser le partenariat entre l’Union Européenne et les pays d’Afrique, les Caraïbes et les pays du Pacifique (ACP) est de toute autre nature que les Accords de Lomé, qui n’ont par ailleurs donné aucun résultat réel concernant le développement et l’émancipation économique et politique des pays pauvres. Les avantages (appauvrissants) du système préférentiel de Lomé instauré entre l’Europe et les ACP sont critiqués par les politiques libéraux. L...

  1. Replication of rs300774, a genetic biomarker near ACP1, associated with suicide attempts in patients with schizophrenia: Relation to brain cholesterol biosynthesis.

    Science.gov (United States)

    Li, Jiang; Yoshikawa, Akane; Meltzer, Herbert Y

    2017-11-01

    The aim of this study was to determine if three biomarkers for suicide attempts previously identified and replicated in a genome-wide association (GWAS) study of bipolar disorder (BD) suicide attempters also predicted suicide attempts in patients prospectively diagnosed with schizophrenia (SCZ) or schizoaffective disorder (SAD). 162 genetically-verified Caucasian patients with SCZ or SAD were phenotyped for presence (45.7%) or absence of a lifetime suicide attempt. Three single nucleotide polymorphisms (SNPs) were genotyped or partially imputed from a GWAS dataset. After controlling for genetic architecture and gender, we replicated rs300774 (p = 0.012), near ACP1 (acid phosphatase 1), the top predictor of suicide attempts in the BD study. The result of Willour et al. (2012) was replicated in males (p = 0.046) but not in females (p = 0.205). The other two SNPs, rs7296262, and rs10437629, were not associated with suicide attempts in this study. rs300774 could be a cis-eQTL for ACP1, with minor allele carriers having lower expression levels (p = 0.002). This SNP also functioned as a trans-eQTL for genes related to cholesterol biosynthesis and the wnt-β-catenin pathway (p ≤ 0.0001). Further, co-expression analysis of candidate genes in brain suggested ACP1 is important to the regulation of a number of brain mechanisms linked to suicide, including cholesterol synthesis, β-catenin-mediated signaling pathway, serotonin, GABA, and the stress response via ARHGAP35 (p190rhogap), a repressor of glucocorticoid receptor (NR3C1) transcription. This study provides an additional validation of rs300774 as a potential transdiagnostic biomarker for suicide attempts and evidence that ACP1 may have an important role in regulation of the multiple systems associated with suicide. Copyright © 2017 Elsevier Ltd. All rights reserved.

  2. A participatory supportive return to work program for workers without an employment contract, sick-listed due to a common mental disorder: an economic evaluation alongside a randomized controlled trial.

    Science.gov (United States)

    Lammerts, Lieke; van Dongen, Johanna M; Schaafsma, Frederieke G; van Mechelen, Willem; Anema, Johannes R

    2017-02-02

    Mental disorders are associated with high costs for productivity loss, sickness absence and unemployment. A participatory supportive return to work (RTW) program was developed in order to improve RTW among workers without an employment contract, sick-listed due to a common mental disorder. The program contained a participatory approach, integrated care and direct placement in a competitive job. The aim of this study was to evaluate the cost-effectiveness and cost-utility of this new program, compared to usual care. In addition, its return on investment was evaluated. An economic evaluation was conducted alongside a 12-month randomized controlled trial. A total of 186 participants was randomly allocated to the new program (n = 94) or to usual care (n = 92). Effect measures were the duration until sustainable RTW in competitive employment and quality-adjusted life years (QALYs) gained. Costs included intervention costs, medical costs and absenteeism costs. Registered data of the Dutch Social Security Agency were used to assess the duration until sustainable RTW, intervention costs and absenteeism costs. QALYs and medical costs were assessed using three- or six-monthly questionnaires. Missing data were imputed using multiple imputations. Cost-effectiveness analysis and cost-utility analysis were conducted from the societal perspective. A return on investment analysis was conducted from the social insurer's perspective. Various sensitivity analyses were performed to assess the robustness of the results. The new program had no significant effect on the duration until sustainable RTW and QALYs gained. Intervention costs and medical costs were significantly higher in the intervention group. From the societal perspective, the maximum probability of cost-effectiveness for duration until sustainable RTW was 0.64 at a willingness to pay of about €10 000/day, and 0.27 for QALYs gained, regardless of the willingness to pay. From the social insurer's perspective, the

  3. A comparison of answer retrieval through four evidence-based textbooks (ACP PIER, Essential Evidence Plus, First Consult, and UpToDate): a randomized controlled trial.

    Science.gov (United States)

    Ahmadi, Seyed-Foad; Faghankhani, Masoomeh; Javanbakht, Anna; Akbarshahi, Maryam; Mirghorbani, Maryam; Safarnejad, Bahareh; Baradaran, Hamid

    2011-01-01

    The efficacy of bedside information products has not been properly evaluated, particularly in developing countries. To compare four evidence-based textbooks by comparing efficacy of their use by clinical residents, as measured by the proportion of questions for which relevant answers could be obtained within 20 min, the time to reach the answer and user satisfaction. One hundred and twelve residents were taught information mastery basics and were randomly allocated to four groups to use: (1) ACP PIER, (2) Essential Evidence Plus (formerly InfoRetriever), (3) First Consult, and (4) UpToDate. Participants received 3 of 24 questions randomly to retrieve the answers from the assigned textbook. Retrieved answers and time-to-answers were recorded by special designed software, and the researchers determined if each recorded answer was relevant. The rate of answer retrieval was 86% in UpToDate, 69% in First Consult, 49% in ACP PIER, and 45% in Essential Evidence Plus (p UpToDate, 15.9 min using First Consult, 16.3 min using Essential Evidence Plus, and 17.3 min using ACP PIER (p UpToDate seems more comprehensive in content and also faster than the other three evidence-based textbooks. Thus, it may be considered as one of the best sources for answering clinicians' questions at the point of care.

  4. Binding of NADP(+) triggers an open-to-closed transition in a mycobacterial FabG β-ketoacyl-ACP reductase.

    Science.gov (United States)

    Blaise, Mickaël; Van Wyk, Niël; Banères-Roquet, Françoise; Guérardel, Yann; Kremer, Laurent

    2017-03-07

    The ketoacyl-acyl carrier protein (ACP) reductase FabG catalyzes the NADPH/NADH dependent reduction of β-ketoacyl-ACP substrates to β-hydroxyacyl-ACP products, the first reductive step in the fatty acid biosynthesis elongation cycle. FabG proteins are ubiquitous in bacteria and are part of the type II fatty acid synthase system. Mining the Mycobacterium smegmatis genome uncovered several putative FabG-like proteins. Among them, we identified M. smegmatis MSMEG_6753 whose gene was found adjacent to MSMEG_6754, encoding a recently characterized enoyl-CoA dehydratase, and to MSMEG_6755, encoding another potential reductase. Recombinantly expressed and purified MSMEG_6753 exhibits ketoacyl reductase activity in the presence of acetoacetyl-CoA and NADPH. This activity was subsequently confirmed by functional complementation studies in a fabG thermosensitive Escherichia coli mutant. Furthermore, comparison of the apo and the NADP(+)-bound MSMEG_6753 crystal structures showed that cofactor binding induces a closed conformation of the protein. A ΔMSMEG_6753 deletion mutant could be generated in M. smegmatis, indicating that this gene is dispensable for mycobacterial growth. Overall, these results showcase the diversity of FabG-like proteins in mycobacteria and new structural features regarding the catalytic mechanism of this important family of enzymes that may be of importance for the rational design of specific FabG inhibitors. © 2017 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society.

  5. Efficacy of a casein phosphopeptide amorphous calcium phosphate (CPP-ACP) paste in preventing white spot lesions in patients with fixed orthodontic appliances: A prospective clinical trial.

    Science.gov (United States)

    Esenlik, E; Uzer Çelik, E; Bolat, E

    2016-12-01

    The aim of this prospective study was to test the efficacy of casein phosphopeptide amorphous calcium phosphate (CPP-ACP) paste applied in-office to prevent white spot lesions (WSL) in patients undergoing fixed orthodontic treatment. Study design: this study was designed as a randomised controlled clinical trial. Fifty-seven patients undergoing nonextraction fixed orthodontic treatment were enrolled and divided randomly into two groups (control n = 28, experimental n = 29). The pretreatment plaque, gingival and bleeding indices, and oral hygiene habits were recorded. One group received CPP-ACP paste (GC Tooth Mousse) at each monthly orthodontic follow-up examination; the control group received routine orthodontic treatment. The mean patient age was 16.9 years in the experimental group and 17.1 years in the control group. The periodontal indices, decayed, missing, and filled teeth (DMFT), decayed, missing, and filled surfaces (DMFS), and the WSL prevalence pre- and post-treatment were measured and compared between the groups. differences between groups in normally distributed data between groups were assessed by the paired-t test, and the Wilcoxon Signed Rank test was used to compare variables that were not normally distributed. There was a lower incidence of WSL in the experimental group compared to the control group. Most of the WSL occurred at the maxillary incisors, mandibular canines and premolars. The in-office application of CPP-ACP paste did not prevent WSL development completely; however, it did significantly decrease the number of WSL compared to the control patients.

  6. Contract Management Process Maturity: Analysis of Recent Organizational Assessments

    OpenAIRE

    Rendon, Rene G.

    2009-01-01

    Proceedings Paper (for Acquisition Research Program) Approved for public release; distribution unlimited. This research builds upon the emerging body of knowledge on organizational assessments of contract management processes. Since the development of the Contract Management Maturity Modelユ_ᄅ in 2003, several DoD, Air Force, Navy, Army, and defense contractor organizations have undergone contract management process assessments as a part of their process-improvement effort. The assessm...

  7. Contract management process maturity: empirical analysis of organizational assessments / by Rene G. Rendon.

    OpenAIRE

    Rendon, Rene G.

    2009-01-01

    This research builds upon the emerging body of knowledge on organizational assessments of contract management processes. Since the development of the Contract Management Maturity Model in 2003, several DoD, Air Force, Navy, Army, and defense contractor organizations have undergone contract management process assessments as a part of their process-improvement effort. The assessments were conducted using the Contract Management Maturity Model (CMMM) as the initial step in a program of contract ...

  8. Applicability of NASA contract quality management and failure mode effect analysis procedures to the USGS Outer Continental Shelf oil and gas lease management program

    Science.gov (United States)

    Dyer, M. K.; Little, D. G.; Hoard, E. G.; Taylor, A. C.; Campbell, R.

    1972-01-01

    An approach that might be used for determining the applicability of NASA management techniques to benefit almost any type of down-to-earth enterprise is presented. A study was made to determine the following: (1) the practicality of adopting NASA contractual quality management techniques to the U.S. Geological Survey Outer Continental Shelf lease management function; (2) the applicability of failure mode effects analysis to the drilling, production, and delivery systems in use offshore; (3) the impact on industrial offshore operations and onshore management operations required to apply recommended NASA techniques; and (4) the probable changes required in laws or regulations in order to implement recommendations. Several management activities that have been applied to space programs are identified, and their institution for improved management of offshore and onshore oil and gas operations is recommended.

  9. 48 CFR 23.706 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... PROGRAMS ENVIRONMENT, ENERGY AND WATER EFFICIENCY, RENEWABLE ENERGY TECHNOLOGIES, OCCUPATIONAL SAFETY, AND... Environmental Assessment of Personal Computer Products, in all solicitations and contracts for— (i) Personal... with its Alternate I when there are sufficient EPEAT Silver registered products available to meet...

  10. A Guide to Educational Performance Contracting.

    Science.gov (United States)

    Hall, G. R.; And Others

    This report is distilled from Rand's findings in previously reported research and from new research. It is addressed to school board members, administrators, and other educational decisionmakers who may be contemplating a performance contracting program. The guide follows the life cycle of a project and identifies the three major phases as…

  11. INDEFINITE CONTRACT REVIEW 2001

    CERN Multimedia

    Human Resources Division

    2001-01-01

    The Director-General has decided to review staff members in professional categories 2 to 5 satisfying the criteria for consideration for the award of an indefinite contract, in accordance with Article R II 1.20 of the Staff Regulations. Staff members holding a fixed-term contract which it has been decided not to renew will not be considered. The following stages are foreseen: 1. Candidates qualifying for review in accordance with Article R II 1.20 of the Staff Regulations and the Administrative Circular N° 9 will be contacted by Human Resources Division. 2. The criteria as to when staff members qualify for review are described in Administrative Circular N° 9. These include the following: staff members who are in their fourth year of service on a fixed-term contract; in addition, for staff members having three years or more of previous relevant service in the Organization on a contract of limited duration (or term-contract) and upon proposal by the division leader concerned, consideration fo...

  12. Energetics of contraction.

    Science.gov (United States)

    Barclay, C J

    2015-04-01

    Muscles convert energy from ATP into useful work, which can be used to move limbs and to transport ions across membranes. The energy not converted into work appears as heat. At the start of contraction heat is also produced when Ca(2+) binds to troponin-C and to parvalbumin. Muscles use ATP throughout an isometric contraction at a rate that depends on duration of stimulation, muscle type, temperature and muscle length. Between 30% and 40% of the ATP used during isometric contraction fuels the pumping Ca(2+) and Na(+) out of the myoplasm. When shortening, muscles produce less force than in an isometric contraction but use ATP at a higher rate and when lengthening force output is higher than the isometric force but rate of ATP splitting is lower. Efficiency quantifies the fraction of the energy provided by ATP that is converted into external work. Each ATP molecule provides 100 zJ of energy that can potentially be converted into work. The mechanics of the myosin cross-bridge are such that at most 50 zJ of work can be done in one ATP consuming cycle; that is, the maximum efficiency of a cross-bridge is ∼50%. Cross-bridges in tortoise muscle approach this limit, producing over 90% of the possible work per cycle. Other muscles are less efficient but contract more rapidly and produce more power. © 2015 American Physiological Society.

  13. INDEFINITE CONTRACT REVIEW 2000

    CERN Multimedia

    Division des ressources humaines

    2000-01-01

    The Director-General has decided to review staff members in professional categories 2 to 5 satisfying the criteria for consideration for the award of an indefinite contract, in accordance with Article R II 1.20 of the Staff Regulations. Staff members holding a fixed-term contract which it has been decided not to renew will not be considered. The following stages are foreseen:1.\tCandidates qualifying for review in accordance with Article R II 1.20 of the Staff Regulations and the Administrative Circular N° 9 will be contacted by Human Resources Division. 2.\tThe criteria as to when staff members qualify for review are described in Administrative Circular N° 9. These include the following:staff members who are in their fourth year of service on a fixed-term contract;in addition, for staff members having three years or more of previous relevant service in the Organization on a contract of limited duration (or term-contract) and upon proposal by the division leader concerned, consid...

  14. Performance-Driven Interface Contract Enforcement for Scientific Components

    Energy Technology Data Exchange (ETDEWEB)

    Dahlgren, Tamara Lynn [Univ. of California, Davis, CA (United States)

    2008-01-01

    Performance-driven interface contract enforcement research aims to improve the quality of programs built from plug-and-play scientific components. Interface contracts make the obligations on the caller and all implementations of the specified methods explicit. Runtime contract enforcement is a well-known technique for enhancing testing and debugging. However, checking all of the associated constraints during deployment is generally considered too costly from a performance stand point. Previous solutions enforced subsets of constraints without explicit consideration of their performance implications. Hence, this research measures the impacts of different interface contract sampling strategies and compares results with new techniques driven by execution time estimates. Results from three studies indicate automatically adjusting the level of checking based on performance constraints improves the likelihood of detecting contract violations under certain circumstances. Specifically, performance-driven enforcement is better suited to programs exercising constraints whose costs are at most moderately expensive relative to normal program execution.

  15. Amending Contracts for Choreographies

    Directory of Open Access Journals (Sweden)

    Laura Bocchi

    2011-07-01

    Full Text Available Distributed interactions can be suitably designed in terms of choreographies. Such abstractions can be thought of as global descriptions of the coordination of several distributed parties. Global assertions define contracts for choreographies by annotating multiparty session types with logical formulae to validate the content of the exchanged messages. The introduction of such constraints is a critical design issue as it may be hard to specify contracts that allow each party to be able to progress without violating the contract. In this paper, we propose three methods that automatically correct inconsistent global assertions. The methods are compared by discussing their applicability and the relationships between the amended global assertions and the original (inconsistent ones.

  16. PROCUREMENT AND CONTRACT MANAGEMENT

    CERN Multimedia

    Training & Development Group; Linda Orr-Easo; Tel. 72460; Nathalie Dumeaux; Tel. 78144

    2001-01-01

    We are pleased to announce the launch of a new training on: Procurement and Contract Management (This seminar will be run by CERN experts in French or in English) Level 1 The aim is to raise awareness of the key issues involved. Date : 8 June 2001 This level is open to everyone. Participants should register via our Web page as soon as possible. Level 2 To develop the skills needed to effectively manage contracts, from the Technical, Commercial and Legal aspects. Dates : Three days, Autumn 2001 This Level is open to those who are/will be more directly responsible for procurement and contract management. Participants should have followed Level 1. For a description of the seminar, please consult:   Level 1: http://training.web.cern.ch/Training/MANCO/P9798/9-cm_e.htm Level 2: http://training.web.cern.ch/Training/MANCO/P9798/9-cm2_e.htm

  17. Statutes and contracts

    DEFF Research Database (Denmark)

    Trosborg, Anna

    1995-01-01

    This paper is concerned with the language used in legal speech acts in legislative texts and contracts in the field of English Contract Law. The central objects of study are regulative functions with a particular view to establishing realization patterns of the rhetorical functions of directive...... and commissive acts. The findings show that the language of the law characteristically selects patterns of regulative distinct from, for example, the patterns typically selected in everyday conversational English. The characteristics of the language of the law can be interpreted within the adherence to legal...

  18. Do contracts help?

    DEFF Research Database (Denmark)

    Tumennasan, Norovsambuu

    Economists perceive moral hazard as an undesirable problem because it undermines efficiency. Carefully designed contracts can mitigate the moral hazard problem, but this assumes that a team is already formed. This paper demonstrates that these contracts are sometimes the reason why teams do...... transfers, then moral hazard affects stability positively in a large class of games. For example, a stable team structure exists if teams produce public goods or if the quota is two. However, these existence results no longer hold if efforts are verifiable....

  19. 14 CFR 1245.301 - Inventions under NASA contracts.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Inventions under NASA contracts. 1245.301... INTELLECTUAL PROPERTY RIGHTS NASA Foreign Patent Program § 1245.301 Inventions under NASA contracts. (a... providing for the granting of a waiver of title to a contractor to any identified invention in countries...

  20. Compositional specification of commercial contracts

    DEFF Research Database (Denmark)

    Andersen, Jesper; Elsborg, Ebbe; Henglein, Fritz

    2006-01-01

    We present a declarative language for compositional specification of contracts governing the exchange of resources. It extends Eber and Peyton Jones’s declarative language for specifying financial contracts (Jones et al. in The Fun of Programming. 2003) to the exchange of money, goods and services...

  1. THE EUROPEAN UNION’S TRADE NEGOTIATIONS WITH THE ACP:ENTRAPPED BY ITS OWN RHETORICAL STRATEGY?

    Directory of Open Access Journals (Sweden)

    Lotte Drieghe

    2008-12-01

    Full Text Available This paper deals with the Economic Partnership Agreements (EPAs between the European Union (EU and the group of African, Caribbean and Pacific (ACP countries. It addresses the question why the EU firmly insisted on upholding the negotiating deadline for these new trade agreements, despite the very damaging consequences; these hastily initialed trade deals entailed. Regional integration in the South was hampered; the development of the friendly image of the EU got a serious blow; the EU did not manage to include the WTO plus issues, and the prospect of full EPAs at later stage is not guaranteed. We first qualify the Union’s argument to the expiry of a waiver by the World Trade Organization (WTO, which legitimized the former trade regime, and placed an external and insurmountable pressure on the negotiations. There is no rational explanation for Europe’s harsh attitude on the EPA deadline, since neither legal, nor economic interests would have been harmed, if the deadline had been postponed. The main argument advanced in this article addresses whether the EU had to push through these trade deals, because it had entrapped itself through its own ‘rhetorical action’. In its negotiation discourse, the European Commission (EC had so often emphasized the deadline together with the fact that there were no alternatives to EPAs, that it could not change its mind overnight, when at the end of the 2007 negotiations they were still going nowhere. The Union was forced to keep up with the deadline it had imposed upon itself with the risk of losing all its credibility.

  2. 3 CFR - Government Contracting

    Science.gov (United States)

    2010-01-01

    ... contract oversight could reduce such sums significantly. Government outsourcing for services also raises... commercial services used by the Government, such as transportation, food, and maintenance. Office of... governmental functions. Agencies and departments must operate under clear rules prescribing when outsourcing is...

  3. Culture and Contract Laws

    DEFF Research Database (Denmark)

    Lando, Ole

    2007-01-01

    In the article it is argued that the wish to preserve the cultural values of national law should not prevent the EU from preparing a Code or an Optional Instrument. The no-code countries on the British Isles and in Scandinavia are the most ardent opponents to the idea of unifying European Contract...

  4. Muscle contraction and force

    DEFF Research Database (Denmark)

    Brüggemann, Dagmar Adeline; Risbo, Jens; Pierzynowski, Stefan G.

    2008-01-01

    Muscle contraction studies often focus solely on myofibres and the proteins known to be involved in the processes of sarcomere shortening and cross-bridge cycling, but skeletal muscle also comprises a very elaborate ancillary network of capillaries, which not only play a vital role in terms of nu...... contributor to force transfer within muscular tissue....

  5. Joint Contingency Contracting

    Science.gov (United States)

    2005-06-01

    parents, Ellsworth K. Johnson, Jr. and Helen E. Johnson, for their lifelong love and support. Mom, thanks for always being there when I needed you...Hurricanes Charley , Jeanne and Andrew are examples of domestic disaster emergency relief. 2. Phases of Contingency Contracting Contingency

  6. Construction Contract Provisions Analysis.

    Science.gov (United States)

    1982-09-01

    tractor, and localized variations characteristic of the subsurface materials of the region are anticipated and if encountered, such variations will...34Contract drawings, maps, and specification. On larger projects, provide one set of sepias , both large scale and reduced, in addition to the contact

  7. Cognition and Incomplete Contracts

    OpenAIRE

    Jean Tirole

    2009-01-01

    Thinking about contingencies, designing covenants, and seeing through their implications is costly. Parties to a contract accordingly use heuristics and leave it incomplete. The paper develops a model of limited cognition and examines its consequences for contractual design. (JEL D23, D82, D86, L22)

  8. Utility Energy Services Contracts: Enabling Documents, May 2009 (Book)

    Energy Technology Data Exchange (ETDEWEB)

    2009-05-01

    Enabling Documents, delivered by the U.S. Department of Energy's Federal Energy Management Program (FEMP) to provide materials that clarify the authority for federal agencies to enter into utility energy services contracts (UESCs).

  9. Practical concepts in Contract Law

    OpenAIRE

    Ehsan, zarrokh

    2008-01-01

    A contract is a legally binding exchange of promises or agreement between parties that the law will enforce. Contract law is based on the Latin phrase pacta sunt servanda (literally, promises must be kept) [1]. Breach of a contract is recognised by the law and remedies can be provided. Almost everyone makes contracts everyday. Sometimes written contracts are required, e.g., when buying a house [2]. However the vast majority of contracts can be and are made orally, like buying a law text book,...

  10. Employee contract issues for dermatologists.

    Science.gov (United States)

    Brown, Christopher E; Indest, George F

    2013-12-01

    Employees and employers routinely face negotiating and preparing physician employment contracts. It is important for both sides to know and understand the basic information on what a comprehensive employment contract for a dermatologist should contain. There are various employment contract provisions from both the employee's perspective and the employer's perspective that must be considered when preparing physician employment contracts. This article provides basic advice and recommendations on requirements that should be included in such contracts. It suggests legal pitfalls that can be avoided through various contract clauses.

  11. The logic of ACP

    NARCIS (Netherlands)

    A. Ponse (Alban); M.B. van der Zwaag

    2002-01-01

    textabstractWe distinguish two interpretations for the truth value `undefined' in Kleene's three-valued logic. Combining these two interpretations leads to a four-valued propositional logic that characterizes two particular ingredients of process algebra: ``choice' and ``inaction'. We study two

  12. Contract-Driven Testing of JavaScript Code

    Science.gov (United States)

    Heidegger, Phillip; Thiemann, Peter

    JSConTest is a tool that enhances JavaScript with simple, type-like contracts and provides a framework for monitoring and guided random testing of programs against these contracts at the same time. Function contracts in JSConTest serve a dual role as specifications of the input/output behavior and as test case generators. Generation of test data for a contract is generally random, but it can be guided by annotations on the contract to achieve higher coverage. Annotations may indicate dependencies among parameters and the result or they may select lightweight program analyses, the results of which influence the choice of test data. A case study substantiates that JSConTest finds type-related errors with high probability.

  13. Navy construction contract regulations vs. the Board of Contract Appeals.

    OpenAIRE

    McMurray, Thomas David

    1987-01-01

    Approved for public release; distribution is unlimited This thesis addresses construction contracting in the United States Navy. It compares the Government construction contract regulations with decisions by the Boards of Contract Appeals. Nine topics are researched including submittal reviews, profit, change orders and changes, notices to proceed, acceleration, beneficial occupancy, weather delays, and extended overhead. The Boards' decisions are used to understand...

  14. Determination of the crystal structure and active residues of FabV, the enoyl-ACP reductase from Xanthomonas oryzae.

    Directory of Open Access Journals (Sweden)

    He Li

    Full Text Available BACKGROUND: Enoyl-ACP reductase (ENR catalyses the last reduction reaction in the fatty acid elongation cycle in bacteria and is a good antimicrobial target candidate. FabV is the most recently discovered class of ENR, but we lack information about the atomic structure and the key residues involved in reductase activity except for the known conserved tyrosine and lysine residues in the Y-X(8-K active site motif. METHODOLOGY/PRINCIPAL FINDINGS: Here we report the crystal structure of FabV from Xanthomonas oryzae (xoFabV. The crystal structure of this enzyme has been solved to 1.6 Å resolution in space group P2(12(12(1. The model of xoFabV consists of one monomer in the asymmetric unit which is composed of 13 α-helices and 11 β-strands, representing a canonical Rossmann fold architecture. Structural comparison presents that the locations of the conserved tyrosine (Y236 and lysine (K245 residues in the Y-X(8-K active site motif of xoFabV and the Y-X(6-K motif of ecFabI are notably similar. However, the conformations of Y236 in xoFabV and Y156 in ecFabI are distinct. Structure-based site-directed mutagenesis and enzymatic activity assays reveal that in addition to the conserved Y236 and K245 in the Y-X(8-K motif, Y53, D111 and Y226 are key residues implicated in the reductase activity, and F113 and T276 are also important for enzyme function. Moreover, a proposed active lysine located immediately after the Y-X(8-K motif in FabV from Burkholderia mallei (bmFabV is altered to an inactive V246 in xoFabV. CONCLUSIONS/SIGNIFICANCE: We determine the first crystal structure of the FabV enzyme and identify several residues important for its enzymatic activity. These findings lay a solid foundation for the development of specific antibacterial inhibitors of the pathogenic bacteria, such as Vibrio cholerae, Burkholderia species and Xanthomonas species.

  15. Multiple receptor conformers based molecular docking study of fluorine enhanced ethionamide with mycobacterium enoyl ACP reductase (InhA).

    Science.gov (United States)

    Khan, Akib Mahmud; Shawon, Jakaria; Halim, Mohammad A

    2017-10-01

    A major limitation in current molecular docking method is that of failure to account for receptor flexibility. Herein we report multiple receptor conformers based molecular docking as a practical alternative to account for the receptor flexibility. Multiple (forty) conformers of Mycobacterium Enoyl ACP Reductase (InhA) are generated from Molecular Dynamics simulation and twenty crystallographic structures of InhA bound to different inhibitors are obtained from the Protein Data Bank. Fluorine directed modifications are performed to currently available anti-tuberculosis drug ethionamide. The modified drugs are optimized using B3LYP 6-31G (d,p) level of theory. Dipole moment, frontier orbital gap and thermodynamical properties such as electronic energy, enthalpy and Gibbs free energy of these optimized drugs are investigated. These drugs are subsequently docked against the conformers of InhA. Molecular docking against multiple InhA conformations show variation in ligand binding affinity and suggest that Ser94, Gly96, Lys165 and Ile194 amino acids play critical role on strong drug-InhA interaction. Modified drug N1 showed greater binding affinity compared to EN in most conformations. Structure of PDB ID: 2NSD and snapshot conformer at 5.5ns show most favorable binding with N1 compared to other conformers. Fluorine participates in forming fluorine bonds and contributes significantly in increasing binding affinity. Our study reveal that addition of trifluoromethyl group explicitly shows promise in improving thermodynamic properties and in enhancing hydrogen bonding and non-bonded interactions. Molecular dynamics (MD) simulation show that EN and N1 remained in the binding pocket similar to the docked pose of EN-InhA and E1-InhA complexes and also suggested that InhA binds to its inhibitor in inhibitor-induced folding manner. ADMET calculations predict modified drugs to have improved pharmacokinetic properties. Our study concludes that multiple receptor conformers based

  16. 48 CFR 819.7004 - Contracting Order of Priority.

    Science.gov (United States)

    2010-10-01

    ... SOCIOECONOMIC PROGRAMS SMALL BUSINESS PROGRAMS Service-Disabled Veteran-Owned and Veteran-Owned Small Business Acquisition Program 819.7004 Contracting Order of Priority. In determining the acquisition strategy applicable... limited to SDVOSBs; (c) Pursuant to— (1) Section 8(a) of the Small Business Act (15 U.S.C. 637(a)); or (2...

  17. Contracts for dispatchable power

    Energy Technology Data Exchange (ETDEWEB)

    Kahn, E.P.; Stoft, S.; Marnay, C.; Berman, D.

    1990-10-01

    Competitive bidding for electric power is maturing. Increasing numbers of utilities are soliciting proposals from private suppliers. The amount of capacity being sought is increasing, and potential suppliers appear to be abundant. Analysis of these developments still remains limited. Evidence on the behavior of this market is scarce and sketchy. The underlying economic principles that are shaping the market have not clearly been articulated. In this report we examine the economics of competitive bidding both empirically and analytically. Previous study of this market has focused on the evaluation criteria specified in Requests for Proposals (RFPs), and highly aggregated summary statistics on participation and results. We continue the examination of RFPs, but also survey the details of long term contracts that have emerged from competitive bidding. Contracts provide a new level of specific detail that has not been previously available. 68 refs., 13 figs., 25 tabs.

  18. Preliminary Results Towards Contract Monitorability

    Directory of Open Access Journals (Sweden)

    Annalizz Vella

    2016-05-01

    Full Text Available This paper discusses preliminary investigations on the monitorability of contracts for web service descriptions. There are settings where servers do not guarantee statically whether they satisfy some specified contract, which forces the client (i.e., the entity interacting with the server to perform dynamic checks. This scenario may be viewed as an instance of Runtime Verification, where a pertinent question is whether contracts can be monitored for adequately at runtime, otherwise stated as the monitorability of contracts. We consider a simple language of finitary contracts describing both clients and servers, and develop a formal framework that describes server contract monitoring. We define monitor properties that potentially contribute towards a comprehensive notion of contract monitorability and show that our simple contract language satisfies these properties.

  19. Utility Energy Services Contracts Guide

    Energy Technology Data Exchange (ETDEWEB)

    None

    2013-09-01

    The UESC Guide is a compilation of samples and templates developed as a resource to help contracting officers implement task orders for UESCs under existing U.S. General Services Administration areawide contracts.

  20. Enzymatic assembly of epothilones: the EpoC subunit and reconstitution of the EpoA-ACP/B/C polyketide and nonribosomal peptide interfaces.

    Science.gov (United States)

    O'Connor, Sarah E; Chen, Huawei; Walsh, Christopher T

    2002-04-30

    The biosynthesis of epothilones, a family of hybrid polyketide (PK)/nonribosomal peptide (NRP) antitumor agents, provides an ideal system to study a hybrid PK/NRP natural product with significant biomedical value. Here the third enzyme involved in epothilone production, the five domain 195 kDa polyketide synthase (PKS) EpoC protein, has been expressed and purified from Escherichia coli. EpoC was combined with the first two enzymes of the epothilone biosynthesis pathway, the acyl carrier protein (ACP) domain of EpoA and EpoB, to reconstitute the early steps in epothilone biosynthesis. The acyltransferase (AT) domain of EpoC transfers the methylmalonyl moiety from methylmalonyl-CoA to the holo HS-acyl carrier protein (ACP) in an autoacylation reaction. The ketosynthase (KS) domain of EpoC decarboxylates the methylmalonyl-S-EpoC acyl enzyme to generate the carbon nucleophile that reacts with methylthiazolylcarboxyl-S-EpoB. The resulting condensation product can be reduced in the presence of NADPH by the ketoreductase (KR) domain of EpoC and then dehydrated by the dehydratase (DH) domain to produce the methylthiazolylmethylacrylyl-S-EpoC acyl enzyme intermediate that serves as the acyl donor for subsequent elongation of the epothilone chain. The acetyl-CoA donor can be replaced with propionyl-CoA, isobutyryl-CoA, and benzoyl-CoA and the acyl chains accepted by both EpoB and EpoC subunits to produce ethyl-, isopropyl-, and phenylthiazolylmethylacrylyl-S-EpoC acyl enzyme intermediates, suggesting that future combinatorial biosynthetic variations in epothilone assembly may be feasible. These results demonstrate in vitro reconstitution of both the PKS/NRPS interface (EpoA-ACP/B) and the NRPS/PKS interface (EpoB/C) in the assembly line for this antitumor natural product.

  1. Effect of CPP-ACP paste with and without CO2 laser irradiation on demineralized enamel microhardness and bracket shear bond strength

    Directory of Open Access Journals (Sweden)

    Nasrin Farhadian

    Full Text Available ABSTRACT Introduction: Many patients seeking orthodontic treatment already have incipient enamel lesions and should be placed under preventive treatments. The aim of this in vitro study was to evaluate the effect of CPP-ACP paste and CO2 laser irradiation on demineralized enamel microhardness and shear bond strength of orthodontic brackets. Methods: Eighty caries-free human premolars were subjected to a demineralization challenge using Streptococcus mutans. After demineralization, the samples were randomly divided into five equal experimental groups: Group 1 (control, the brackets were bonded without any surface treatment; Group 2, the enamel surfaces were treated with CPP-ACP paste for 4 minutes before bonding; Group 3, the teeth were irradiated with CO2 laser beams at a wavelength of 10.6 µm for 20 seconds. The samples in Groups 4 and 5 were treated with CO2 laser either before or through CPP-ACP application. SEM photomicrographs of a tooth from each group were taken to observe the enamel surface. The brackets were bonded to the buccal enamel using a conventional method. Shear bond strength of brackets and ARI scores were measured. Vickers microhardness was measured on the non-bonded enamel surface. Data were analyzed with ANOVA and Tukey test at the p< 0.05 level. Results: The mean shear bond strength and microhardness of the laser group were higher than those in the control group and this difference was statistically significant (p< 0.05. All groups showed a higher percentage of ARI score 4. Conclusion: CO2 laser at a wavelength of 10.6 µm significantly increased demineralized enamel microhardness and enhanced bonding to demineralized enamel.

  2. The Crystal Structure of the Ivy delta4-16:0-ACP Desaturase Reveals Structural Details of the Oxidized Active Site and Potential Determinants of Regioselectivity

    Energy Technology Data Exchange (ETDEWEB)

    Guy,J.; Whittle, E.; Kumaran, D.; Lindqvist, Y.; Shanklin, J.

    2007-01-01

    The multifunctional acyl-acyl carrier protein (ACP) desaturase from Hedera helix (English ivy) catalyzes the {Delta}{sup 4} desaturation of 16:0-ACP and the{Delta}{sup 9} desaturation of 18:0-ACP and further desaturates{Delta}{sup 9}-16:1 or {Delta}{sup 9}-18:1 to the corresponding {Delta}{sup 4,9} dienes. The crystal structure of the enzyme has been solved to 1.95{angstrom} resolution, and both the iron-iron distance of 3.2{angstrom} and the presence of a {mu}-oxo bridge reveal this to be the only reported structure of a desaturase in the oxidized FeIII-FeIII form. Significant differences are seen between the oxidized active site and the reduced active site of the Ricinus communis (castor) desaturase; His{sup 227} coordination to Fe2 is lost, and the side chain of Glu{sup 224}, which bridges the two iron ions in the reduced structure, does not interact with either iron. Although carboxylate shifts have been observed on oxidation of other diiron proteins, this is the first example of the residue moving beyond the coordination range of both iron ions. Comparison of the ivy and castor structures reveal surface amino acids close to the annulus of the substrate-binding cavity and others lining the lower portion of the cavity that are potential determinants of their distinct substrate specificities. We propose a hypothesis that differences in side chain packing explains the apparent paradox that several residues lining the lower portion of the cavity in the ivy desaturase are bulkier than their equivalents in the castor enzyme despite the necessity for the ivy enzyme to accommodate three more carbons beyond the diiron site.

  3. Effect of CPP-ACP paste with and without CO2 laser irradiation on demineralized enamel microhardness and bracket shear bond strength.

    Science.gov (United States)

    Farhadian, Nasrin; Rezaei-Soufi, Loghman; Jamalian, Seyed Farzad; Farhadian, Maryam; Tamasoki, Shahrzad; Malekshoar, Milad; Javanshir, Bahareh

    2017-01-01

    Many patients seeking orthodontic treatment already have incipient enamel lesions and should be placed under preventive treatments. The aim of this in vitro study was to evaluate the effect of CPP-ACP paste and CO2 laser irradiation on demineralized enamel microhardness and shear bond strength of orthodontic brackets. Eighty caries-free human premolars were subjected to a demineralization challenge using Streptococcus mutans. After demineralization, the samples were randomly divided into five equal experimental groups: Group 1 (control), the brackets were bonded without any surface treatment; Group 2, the enamel surfaces were treated with CPP-ACP paste for 4 minutes before bonding; Group 3, the teeth were irradiated with CO2 laser beams at a wavelength of 10.6 µm for 20 seconds. The samples in Groups 4 and 5 were treated with CO2 laser either before or through CPP-ACP application. SEM photomicrographs of a tooth from each group were taken to observe the enamel surface. The brackets were bonded to the buccal enamel using a conventional method. Shear bond strength of brackets and ARI scores were measured. Vickers microhardness was measured on the non-bonded enamel surface. Data were analyzed with ANOVA and Tukey test at the p< 0.05 level. The mean shear bond strength and microhardness of the laser group were higher than those in the control group and this difference was statistically significant (p< 0.05). All groups showed a higher percentage of ARI score 4. CO2 laser at a wavelength of 10.6 µm significantly increased demineralized enamel microhardness and enhanced bonding to demineralized enamel.

  4. Effects of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP and fluoride on the microhardness of enamel treated with a bleaching agent: ex vivo

    Directory of Open Access Journals (Sweden)

    Mügem Aslı Gürel Ekici

    2017-05-01

    Full Text Available Objective: The aim of this study was to compare the effects of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP and 1.23% acidulated phosphate fluoride (APF; pH 3.5 on the microhardness of enamel treated with a bleaching agent. Materials and Method: Enamel slices (n=32; 2×4 mm were obtained from 8 mandibular permanent molar teeth. Specimens were embedded into acrylic resin blocks with the enamel surfaces facing upwards. Vickers microhardness (VHN values of the specimens were recorded at baseline. The specimens were randomly divided into 4 experimental groups, and the experimental designation was as follows: Group 1: no treatment (control, Group 2: 35% hydrogen peroxide (HP, Group 3: HP + CPP-ACP, Group 4: HP + APF application. After treatments, VHN values were measured and recorded again. Specimens were stored in artificial saliva at 37 °C for 1 week. After 1 week second application was done and VHN of the specimens was registered once more. Data were statistically analyzed with ANOVA and Tukey post hoc tests. Values obtained at baseline, and first and second applications were compared using paired samples t-test (α=0.05. Results: In inter-group comparisons, no statistically significant difference in the enamel microhardness values was found between the baseline, and first and second applications (p>0.05. In intra-group comparisons, again, no statistically significant difference in the enamel microhardness values was found between the baseline, and first and second applications (p>0.05. Conclusion: According to the limitations of this study it can be concluded that neither the HP application nor the CPP-ACP or APF application after HP had any significant effect on the enamel microhardness.

  5. CONTRACT FOLLOW UP TRAINING

    CERN Multimedia

    Technical Training; Tel. 74460

    2001-01-01

    SPL is organizing Training Sessions on the Contract Follow Up application. CFU is a Web based tool, developped and supported by the Administrative Information Services. It allows the creation of Divisional Requests and the follow up of their processing, from the Market Survey to the Invitation to Tender or Price Enquiry, approval by the Finance Committee, up to the actual signature of a Contract, acccording to the CERN Purchasing procedures. It includes a document management component. It also provides link with other AIS applications such as BHT and EDH. The course is primarily intended for DPOs, Contract Technical responsibles in the division and their assistants, but is beneficial to anybody involved in the follow up of such Purchasing Procedures. This course is free of charge, but application is necessary. The details of the course may be found at http://training.web.cern.ch/Training/ENSTEC/P2001/Bureautique/cfu4_f.htm General information of CFU may be found at http://ais.cern.ch/apps/cfu/ The dates of t...

  6. The interpretation of administrative contracts

    Directory of Open Access Journals (Sweden)

    Cătălin-Silviu SĂRARU

    2014-06-01

    Full Text Available The article analyzes the principles of interpretation for administrative contracts, in French law and in Romanian law. In the article are highlighted derogations from the rules of contract interpretation in common law. Are examined the exceptions to the principle of good faith, the principle of common intention (willingness of the parties, the principle of good administration, the principle of extensive interpretation of the administrative contract. The article highlights the importance and role of the interpretation in administrative contracts.

  7. Obstacles sanitaires, phytosanitaires et techniques au commerce dans les Accords de partenariat économique entre l'Union européenne et les pays ACP

    OpenAIRE

    Prévost, Denise

    2010-01-01

    L'étude expose une vision commune sur des questions qui pourraient constituer des obstacles sanitaires, phytosanitaires et techniques dans les APE et examine dans quelle mesure un recours abusif à ces dispositions pourrait être un obstacle à l'accès au marché. L'étude promeut également le partage d'expérience entre différentes régions ACP en termes d'établissement des positions de négociation. Les questions couvertes comprennent : Les disciplines dans les APE sur des obstacles traditionnels à...

  8. Une reconnexion asymétrique : le cas des accords de partenariat économique entre l'UE et les ACP

    OpenAIRE

    Abbas, Mehdi

    2008-01-01

    Le premier janvier 2008 inaugure une nouvelle phase dans la politique de coopération économique pour le développement de l'Union européenne (UE), phase caractérisée par la ratification d'accords de partenariat économique (APE) avec les économies d'Afrique, Caraïbes et Pacifique (ACP). Les APE sonnent le glas de la dimension commerciale contenue dans les accords de Cotonou et redéfinissent la forme et la substance des rapports qu'entretiennent les vingt-sept membres de l'UE avec les soixante-d...

  9. Sustainable Exploitation of Maritime Stocks in the West African Marine Eco-Region within the Context of ACP-EU Relation

    OpenAIRE

    2003-01-01

    This paper will mainly focus on the Western Africa Marine Eco-Region, (WAMER) composed of Mauritania, Senegal, Cape Verde, The Gambia, Guinea-Bissau and Guinea. Since all the countries in this eco-region, except The Gambia, have fisheries agreements with the European Union (EU), they provide an interesting example of ACP-EU relations in the fishery sector. In the WAMER eco-region, the fishery sector is a source of foreign currency, jobs and food for more than 22 million people. A look at t...

  10. Why radiologists lose their hospital contracts: is your contract secure?

    Science.gov (United States)

    Muroff, Lawrence R

    2010-03-01

    Previously, a hospital contract meant tenure for the incumbent group of radiologists; however, those days are long gone. Exclusive contracts have morphed into exclusive contracts with carve-outs. Turf erosion has become a fact of life for radiology practices. Now radiologists are losing their hospital contracts in record numbers. Group size, though helpful for a variety of reasons, does not ensure that a practice will be secure in its hospital setting. The reasons that groups lose their hospital contracts are varied, and in this paper, the author discusses the most common ones. Suggestions to help practices avoid this unfortunate fate are presented.

  11. Pressure drop in contraction flow

    DEFF Research Database (Denmark)

    Rasmussen, Henrik Koblitz

    This note is a supplement to Dynamic of Polymeric Liquids (DPL) page 178. DPL gives an equation for the pressure drop in a tapered (and circular) contraction, valid only at low angles. Here the general definition of contraction flow (the Bagley correction) and a more general method to find...... the pressure drop in a contraction are given....

  12. Service quality in contracted facilities.

    Science.gov (United States)

    Rabbani, Fauziah; Pradhan, Nousheen Akber; Zaidi, Shehla; Azam, Syed Iqbal; Yousuf, Farheen

    2015-01-01

    The purpose of this paper is to explore the readiness of contracted and non-contracted first-level healthcare facilities in Pakistan to deliver quality maternal and neonatal health (MNH) care. A balanced scorecard (BSC) was used as the assessment framework. Using a cross-sectional study design, two rural health centers (RHCs) contracted out to Aga Khan Health Service, Pakistan were compared with four government managed RHCs. A BSC was designed to assess RHC readiness to deliver good quality MNH care. In total 20 indicators were developed, representing five BSC domains: health facility functionality, service provision, staff capacity, staff and patient satisfaction. Validated data collection tools were used to collect information. Pearson χ2, Fisher's Exact and the Mann-Whitney tests were applied as appropriate to detect significant service quality differences among the two facilities. Contracted facilities were generally found to be better than non-contracted facilities in all five BSC domains. Patients' inclination for facility-based delivery at contracted facilities was, however, significantly higher than non-contracted facilities (80 percent contracted vs 43 percent non-contracted, p=0.006). The study shows that contracting out initiatives have the potential to improve MNH care. This is the first study to compare MNH service delivery quality across contracted and non-contracted facilities using BSC as the assessment framework.

  13. Transnational Law of Public Contracts

    NARCIS (Netherlands)

    Audit, M.; Schill, S.W.

    2016-01-01

    Public contracts were traditionally conceived as instruments of domestic public law and used within markets confined to the territory of the state party to the contract. Globalization, however, subjects public contracting to an increasing number of processes that take place at a transnational level

  14. 48 CFR 1819.708 - Contract clauses. (NASA supplements paragraph (b))

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Contract clauses. (NASA supplements paragraph (b)) 1819.708 Section 1819.708 Federal Acquisition Regulations System NATIONAL... Subcontracting Program 1819.708 Contract clauses. (NASA supplements paragraph (b)) (b)(1) The contracting officer...

  15. cASM: Obtaining the Ability to Capture Requirements Information Across the Installation Contracting Support Community

    Science.gov (United States)

    2016-04-22

    multiple electronic systems that facilitate contract generation, contract administration , acquisition history and acquisition spend analysis. Data must...8 Literature Review – The Evolution from Research to Doctrine...a brief history of the installation and contingency contracting environments and shown how the IAT program has proceeded but has not yet reached

  16. The Lanthanide Contraction Revisited

    Science.gov (United States)

    Seitz, Michael; Oliver, Allen G.; Raymond, Kenneth N.

    2011-01-01

    A complete, isostructural series of complexes with La-Lu (except Pm) with the ligand TREN-1,2-HOIQO has been synthesized and structurally characterized by means of single-crystal X-ray analysis. All complexes are 1D-polymeric species in the solid state, with the lanthanide being in an eight-coordinate, distorted trigonal-dodecahedral environment with a donor set of eight unique oxygen atoms. This series constitutes the first complete set of isostructural complexes from La-Lu (without Pm) with a ligand of denticity greater than two. The geometric arrangement of the chelating moieties slightly deviates across the lanthanide series, as analyzed by a shape parameter metric based on the comparison of the dihedral angles along all edges of the coordination polyhedron. The apparent lanthanide contraction in the individual Ln-O bond lengths deviates considerably from the expected quadratic decrease that was found previously in a number of complexes with ligands of low denticity. The sum of all bond lengths around the trivalent metal cation, however, is more regular, showing an almost ideal quadratic behavior across the entire series. The quadratic nature of the lanthanide contraction is derived theoretically from Slater’s model for the calculation of ionic radii. In addition, the sum of all distances along the edges of the coordination polyhedron show exactly the same quadratic dependence as the Ln-X bond lengths. The universal validity of this coordination sphere contraction, concomitant with the quadratic decrease in Ln-X bond lengths, was confirmed by reexamination of four other, previously published series of lanthanide complexes. Due to the importance of multidentate ligands for the chelation of rare-earth metals, this result provides a significant advance for the prediction and rationalization of the geometric features of the corresponding lanthanide complexes, with great potential impact for all aspects of lanthanide coordination. PMID:17705483

  17. The Lanthanide Contraction Revisited

    Energy Technology Data Exchange (ETDEWEB)

    Seitz, Michael; Oliver, Allen G.; Raymond, Kenneth N.

    2007-04-19

    A complete, isostructural series of lanthanide complexes (except Pm) with the ligand TREN-1,2-HOIQO has been synthesized and structurally characterized by means of single-crystal X-ray analysis. All complexes are 1D-polymeric species in the solid state, with the lanthanide being in an eight-coordinate, distorted trigonal-dodecahedral environment with a donor set of eight unique oxygen atoms. This series constitutes the first complete set of isostructural lanthanide complexes with a ligand of denticity greater than two. The geometric arrangement of the chelating moieties slightly deviates across the lanthanide series, as analyzed by a shape parameter metric based on the comparison of the dihedral angles along all edges of the coordination polyhedron. The apparent lanthanide contraction in the individual Ln-O bond lengths deviates considerably from the expected quadratic decrease that was found previously in a number of complexes with ligands of low denticity. The sum of all bond lengths around the trivalent metal cation, however, is more regular, showing an almost ideal quadratic behavior across the entire series. The quadratic nature of the lanthanide contraction is derived theoretically from Slater's model for the calculation of ionic radii. In addition, the sum of all distances along the edges of the coordination polyhedron show exactly the same quadratic dependency as the Ln-X bond lengths. The universal validity of this coordination sphere contraction, concomitant with the quadratic decrease in Ln-X bond lengths, was confirmed by reexamination of four other, previously published, almost complete series of lanthanide complexes. Due to the importance of multidentate ligands for the chelation of rare-earth metals, this result provides a significant advance for the prediction and rationalization of the geometric features of the corresponding lanthanide complexes, with great potential impact for all aspects of lanthanide coordination.

  18. Analysis of Contemporary Contingency Contracting Educational Resources

    Science.gov (United States)

    2010-11-29

    Attn: James B. Greene , RADM, USN, (Ret) Acquisition Chair Graduate School of Business and Public Policy Naval Postgraduate School 555 Dyer Road...Registration CERP Commander’s Emergency Response Program CICA Competition in Contracting Act CJCS Chairman of the Joint Chiefs of Staff CoCo ...334 Matrix OO LCO IPE 1 2 3 4 5 TLO 1 Recognize and defend the most appropriate approaches for a contingency CoCo in an AOR throughout the four

  19. Contracting singular horseshoe

    Science.gov (United States)

    Morales, C. A.; San Martín, B.

    2017-11-01

    We suggest a notion of hyperbolicity adapted to the geometric Rovella attractor (Robinson 2012 An Introduction to Dynamical Systems—Continuous and Discrete (Pure and Applied Undergraduate Texts vol 19) 2nd edn (Providence, RI: American Mathematical Society)) . More precisely, we call a partially hyperbolic set asymptotically sectional-hyperbolic if its singularities are hyperbolic and if its central subbundle is asymptotically sectional expanding outside the stable manifolds of the singularities. We prove that there are highly chaotic flows with Rovella-like singularities exhibiting this kind of hyperbolicity. We shall call them contracting singular horseshoes.

  20. Negotiating Efficient PPP Contracts

    DEFF Research Database (Denmark)

    Tvarnø, Christina D.

    should consider tendering out PPP projects in the spirit of joint utility because joint utility can increase the concept of more value for money; the cornerstone of the PPP concept. This paper discusses the positive gains from negotiation and compares it with the upcoming possibilities in the EU public....... Joint utility can increase the concept of more value for money; the cornerstone of the PPP concept. The paper draws upon existing legal content regarding collaboration and common goals and game theory to explain the benefits from implementing similar clauses in PPP contracts....

  1. A Study of Critical Thinking Training in the Army Contracting Workforce

    Science.gov (United States)

    2016-03-23

    the instructors need additional critical thinking skills 3 There are real benefits to DoD acquisition programs when PMs and Contracting Officers...training methods and contracting and business examples could benefit the contracting workforce and emphasize the importance of critical thinking in...Running head: CRITICAL THINKING TRAINING 1 A Study of Critical Thinking Training in the Army Contracting Workforce Cheryl L. Jones

  2. Defining Acquisition and Contracting Terms Associated with Contract Administration

    Science.gov (United States)

    1990-09-01

    Riemer Handbook of Government Contract Administration, the Armed Services Pricing Manual ( ASPM ), and AFIT’s Govern- ment Contract Law course and case book...these duties into general categories, as outlined in the ASPM and Government Contract Cost (16:B-3) (36:25-7,GL-3). NCMA’s Desktop Guide to Basic...processes by listing exactly how an audit is carried out and what it determines. For example, Arnavas, Rishe, and the ASPM conclude that an au- dit is

  3. Project management plan for Contract Management Information System (CONTRACT)

    Energy Technology Data Exchange (ETDEWEB)

    Severud, K.J.

    1995-01-27

    The office of the Vice President of A/E Construction for ICF Kaiser has requested that OSHA compliance statistics be made available to management for companies subcontracting to the ICF Kaiser Company. In addition, a need to better manage contract administrative data for the Contracts Administration and the Construction Management Projects organizations has been identified. The Contract Management Information System is being developed to achieve these objectives. This document provides a Project Management Plan for development of the Contract Management Administration System (CONTRACT) by Design Services DAD/CAE Support. The Project Management Plan describes the project work breakdown structure, safety and quality considerations, with associated cost, schedule and project management information. The CONTRACT System is intended to aid the ICF Kaiser divisions with tracking of A/E subcontractor information to include general contract administration information used by the Contracts Administration organization, contract and safety performance data used by the Construction Management Projects and office of the organization and Vice President of A/E Construction.

  4. 48 CFR 716.406 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 716.406 Section 716.406 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Cost Reimbursement Contracts 716.406 Contract clauses. The...

  5. 48 CFR 1416.405 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 1416.405 Section 1416.405 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Incentive Contracts 1416.405 Contract clauses. The BPC, without the power...

  6. 48 CFR 732.111 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 732.111... CONTRACTING REQUIREMENTS CONTRACT FINANCING General 732.111 Contract clauses. (a) (b) USAID may obtain short... indefinite quantity contracts that are a combination of contract types. Rather than using the fixed-price...

  7. 48 CFR 916.307 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 916.307 Section 916.307 Federal Acquisition Regulations System DEPARTMENT OF ENERGY CONTRACTING METHODS AND CONTRACT TYPES TYPES OF CONTRACTS Cost-Reimbursement Contracts 916.307 Contract clauses. (g) Insert the...

  8. Comparative evaluation of the effects of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and xylitol-containing chewing gum on salivary flow rate, pH and buffering capacity in children: An in vivo study

    OpenAIRE

    Rahul J Hegde; Janhavi B Thakkar

    2017-01-01

    Aim: This study aimed to compare and evaluate the changes in the salivary flow rate, pH, and buffering capacity before and after chewing casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and xylitol-containing chewing gums in children. Materials and Methods: Sixty children aged between 8 and 12 years were selected for the study. They were randomly divided into Group 1 (CPP-ACP chewing gum) and Group 2 (xylitol-containing chewing gum) comprising thirty children each. Unstimulated and...

  9. El conflicto bananero entre América Latina y la Unión Europea ¿por qué la actual preferencia arancelaria ACP no se justifica?

    OpenAIRE

    Sánches Rojas, Omar

    2013-01-01

    El comercio del banano en la UE, ha estado por largo tiempo en disputa en la OMC, debido principalmente a la preferencia otorgada a las naciones ACP en la importación de banano y a restricciones de acceso para la fruta proveniente de América Latina, por lo cual se han realizado infinidad de estudios de orden legal, comercial, político y económico. Sin embargo, se carece de un análisis que evalúe la evolución competitiva del bloque ACP y lo compare con las condiciones actuales del sector ba...

  10. Some ancestors of contraction analysis

    DEFF Research Database (Denmark)

    Jouffroy, Jerome

    2005-01-01

    Contraction analysis is a recent tool for analyzing the convergence behavior of nonlinear systems in state-space form (see Lohmiller and Slotine [16] for the main reference). However, it seems that earlier results derived by mathematicians in the 1950s closely match some of the results...... of contraction analysis. In this paper, we review and place into perspective some references of this era, and relate them with contraction....

  11. Methodological remarks on contraction theory

    DEFF Research Database (Denmark)

    Jouffroy, Jerome; Slotine, Jean-Jacques E.

    classical examples traditionally addressed using Lyapunov theory. Even in these cases, contraction tools can often yield significantly simplified analysis. The examples include adaptive control, robotics, and a proof of convergence of the deterministic Extended Kalman Filter.......Because contraction analysis stems from a differential and incremental framework, the nature and methodology of contraction-based proofs are significantly different from those of their Lyapunov-based counterparts. This paper specifically studies this issue, and illustrates it by revisiting some...

  12. Performance contracts for police forces

    OpenAIRE

    Ben Vollaard

    2003-01-01

    In 2003, the government will enter into performance contracts with each of the 25 regional police forces. The performance contracts establish a direct link between meeting a number of quantitative performance targets and financial incentives. A major improvement in police performance is necessary to meet the objective of 20 to 25 percent less criminal and disorderly behavior by 2006. A closer look at the performance contracts learns that they may not be the most appropriate policy instrument ...

  13. Expansionary fiscal contractions

    DEFF Research Database (Denmark)

    Bergman, Ulf Michael; Hutchison, Michael

    2010-01-01

    The Expansionary Fiscal Contraction (EFC) hypothesis predicts that a major fiscal consolidation leads to an economic expansion under certain circumstances. We test this hypothesis, and the implied non-linear responses of the economy to large and small changes in fiscal policy, using data from...... the 1983 Danish fiscal reform. We use a structural VAR/event study methodology following Blanchard and Perotti (2002) that explicitly allows us to distinguish between normally marginal changes in fiscal policy and comprehensive fiscal reforms. We find that 'marginal changes' in fiscal policy (expenditure...... and tax changes) have the expected Keynesian effects on output and consumption. However, we find no evidence that the large fiscal consolidation in Denmark slowed the economy after controlling for a host of exogenous shocks and business cycle effects. Rather, we find some support for the hypothesis...

  14. The Danish Contracting System

    DEFF Research Database (Denmark)

    Bonke, Sten; Levring, Peter

    development trends are indicated. A third section describes the contemporary external, regulative framework of construction projects. In the two final sections the construction process is decomposed with regard to 1)phases and activities and 2)procurement forms, actors and functions.......The paper is mainly concerned with the institutional framework of the Danish construction industry, describing structures, rules and actors' roles within a perspective of nationally defined procedural guidelines on construction projects. These aspects are treated under the concept of a "contracting...... system". After a short introduction to the structure and activities of the industry the post-war development is reviewed, in particular emphasising the importance of the early industrialisation process which in an international perspective represents quite unique features. Furthermore the most recent...

  15. Forthcoming indefinite contract review procedure

    CERN Multimedia

    Human Resources Department

    2011-01-01

    The vacancy notices for posts opened with a view to the award of an indefinite contract will be published in early April 2011. In the meantime, the list of posts to be opened this spring is available at the following address: Indefinite contract posts - spring 2011 A second exercise will take place in autumn 2011 and, as of 2012, the indefinite contract award procedure will only be held once a year, in autumn. For more information please consult: https://hr-recruit.web.cern.ch/hr-recruit/staff/IndefiniteContracts.asp  

  16. Simplifying Contract-Violating Traces

    Directory of Open Access Journals (Sweden)

    Christian Colombo

    2012-09-01

    Full Text Available Contract conformance is hard to determine statically, prior to the deployment of large pieces of software. A scalable alternative is to monitor for contract violations post-deployment: once a violation is detected, the trace characterising the offending execution is analysed to pinpoint the source of the offence. A major drawback with this technique is that, often, contract violations take time to surface, resulting in long traces that are hard to analyse. This paper proposes a methodology together with an accompanying tool for simplifying traces and assisting contract-violation debugging.

  17. Uterine Contraction Modeling and Simulation

    Science.gov (United States)

    Liu, Miao; Belfore, Lee A.; Shen, Yuzhong; Scerbo, Mark W.

    2010-01-01

    Building a training system for medical personnel to properly interpret fetal heart rate tracing requires developing accurate models that can relate various signal patterns to certain pathologies. In addition to modeling the fetal heart rate signal itself, the change of uterine pressure that bears strong relation to fetal heart rate and provides indications of maternal and fetal status should also be considered. In this work, we have developed a group of parametric models to simulate uterine contractions during labor and delivery. Through analysis of real patient records, we propose to model uterine contraction signals by three major components: regular contractions, impulsive noise caused by fetal movements, and low amplitude noise invoked by maternal breathing and measuring apparatus. The regular contractions are modeled by an asymmetric generalized Gaussian function and least squares estimation is used to compute the parameter values of the asymmetric generalized Gaussian function based on uterine contractions of real patients. Regular contractions are detected based on thresholding and derivative analysis of uterine contractions. Impulsive noise caused by fetal movements and low amplitude noise by maternal breathing and measuring apparatus are modeled by rational polynomial functions and Perlin noise, respectively. Experiment results show the synthesized uterine contractions can mimic the real uterine contractions realistically, demonstrating the effectiveness of the proposed algorithm.

  18. 7 CFR 1940.336 - Contracting for professional services.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 13 2010-01-01 2009-01-01 true Contracting for professional services. 1940.336 Section 1940.336 Agriculture Regulations of the Department of Agriculture (Continued) RURAL HOUSING... OF AGRICULTURE (CONTINUED) PROGRAM REGULATIONS (CONTINUED) GENERAL Environmental Program § 1940.336...

  19. A Review of Advance Care Planning Programs in Long-Term Care Homes: Are They Dementia Friendly?

    Directory of Open Access Journals (Sweden)

    Abigail Wickson-Griffiths

    2014-01-01

    Full Text Available Background. Persons living with dementia in the long-term care home (LTCH setting have a number of unique needs, including those related to planning for their futures. It is therefore important to understand the advance care planning (ACP programs that have been developed and their impact in order for LTCH settings to select a program that best suits residents’ needs. Methods. Four electronic databases were searched from 1990 to 2013, for studies that evaluated the impact of advance care planning programs implemented in the LTCH setting. Studies were critically reviewed according to rigour, impact, and the consideration of the values of residents with dementia and their family members according to the Dementia Policy Lens Toolkit. Results and Conclusion. Six ACP programs were included in the review, five of which could be considered more “dementia friendly.” The programs indicated a variety of positive impacts in the planning and provision of end-of-life care for residents and their family members, most notably, increased ACP discussion and documentation. In moving forward, it will be important to evaluate the incorporation of residents with dementia’s values when designing or implementing ACP interventions in the LTCH settings.

  20. Orchestrating with Contracts

    DEFF Research Database (Denmark)

    Kiniry, Joseph Roland; Martinez, Josu

    2012-01-01

    of the units under composition. Orc is an executable language, and in the Orc system, units are realized as methods implemented in the Java programming language. Since Java methods' behavior can be formally specified with the Java Modeling Language (JML), then the behavior of an Orc program can be reasoned......Our domain of interest is self-healing systems. We wish to reason about the behavior of statically and dynamically composed systems. The orchestration language Orc permits one to write programs that compose such systems. Unfortunately, Orc's semantics make no assumptions about the behavior...

  1. Principles of contracting; Grundlagen des Contracting. Waermecontracting - worauf es ankommt

    Energy Technology Data Exchange (ETDEWEB)

    Meixner, H. [HessenENERGIE, Gesellschaft fuer Rationelle Energienutzung mbH, Wiesbaden (Germany)

    2003-08-01

    Contracting has established itself as a permanent factor in the debate about energy policy and the energy industry. In a survey of senior managers in the German energy sector on the trends and services which will gain heavily in importance from 2002 to 2004, contracting occupied a prime position, immediately after 'New services in general' and 'Multi-utility' and far ahead of 'Electricity trading' or 'Telecommunications/Power lines'. Energy policy expectations of contracting are high and a lot of confidence is being placed in this service. Similarly long-term planning perspectives to those usual for energy generation facilities (e.g. power stations) must thus be facilitated for investment in saving energy. In its original version, contracting is only intended for the implementation of investments dedicated purely to saving energy, if possible, and accompanying measures by third parties. The amortisation of investments made by the contractor from the savings which can be made on energy costs is disputed. In parallel to such 'economy contracting' (also known as 'performance contracting'), energy supply contracting (also known as plant contracting or the supply of useful energy) has predominantly emerged, with a stronger orientation towards ordinary customer energy supply contracts. The user commissions an energy utility to provide the useful energy required. The utility frequently also assumes investment in the necessary technical plant, including planning, finance and operation - analogous to the supply of district heating. Various forms of finance contracting also exist which tend towards leasing and contracting models for the management of existing technical installations, which does not anticipate any (major) investment by the contractor. (orig.) [German] In den 90er Jahren hat Contracting 'Karriere' gemacht - allerdings eher der Begriff als die Sache, die er bezeichnet. Inzwischen sind aber

  2. Contract 98 Self-Assessment

    Energy Technology Data Exchange (ETDEWEB)

    1993-04-01

    This report documents the results of LBL`s Self-Assessment required by Appendix F to Contract DE ACOO3765F00098. This self assessment covers the performance measures set forth in Appendix F except those requiring an external audit. The performance measures for LBL are in the areas of ES&H Finance, Human Services and Procurement and Property. LBL is a multi-program laboratory operated by the University of California (UC) for DOE. The mission of LBL includes performing research in energy, general, and life sciences. LBL facilities include the main site on 130 acres located in the cities of Berkeley and Oakland; laboratories and offices located in buildings on the UC Berkeley Campus; and three leased buildings in the cities of Berkeley and Emeryville. 1. Involvement of Line Management in the assessment process to provide awareness and ownership. 2. Using existing assessments, audits and appraisals in lieu of a new assessment wherever possible. 3. Conduct of the assessments by individuals with functional responsibility and knowledge of the areas being assessed. 4. Interaction with individuals performing assessments at other Laboratories to enhance our learning process. As anticipated, a number of findings will require corrective action. General corrective actions are identified for key findings in this report. In early May 1993, this Laboratory will begin the development of detailed formal corrective action plans which will be entered into a laboratory automated corrective action tracking system.

  3. Different concentration of benzylpenicillin benzatin addition on cryopreserved canine semen using a powdered coconut water extender (ACP-106® Diferentes concentrações de benzilpenicilina benzatina no sêmen canino criopreservado em diluidor à base de água de coco na forma de pó (ACP-106®

    Directory of Open Access Journals (Sweden)

    Lúcia Daniel Machado da Silva

    2010-03-01

    Full Text Available This research aimed at analyzing the effect of benzylpenicillin benzatin addition in different concentrations, on semen motility, morphology and functional spermatic membrane integrity, and of control of bacterial growth on canine semen cryopreserved in ACP-106®. Thirteen ejaculates were used, evaluated and further divided into four aliquots. Each aliquots was extended in ACP-106® with 20% egg yolk and four concentrations of benzylpenicillin benzatin, forming four experimental groups: G0 (without antibiotic; G500 (with 500UI/mL; G1000 (with 1000UI/mL; and G1500 (with 1500UI/mL. After then, the samples were frozen and stored in liquid nitrogen. After about one week, samples were thawed and submitted to spermatic and microbiology evaluations. No differences were observed among groups after thawing regarding seminal parameters, morphology, intact acrossoma and percentual of live spermatozoa, as well for the number of UFC/L. In computerized analyzes, it was also evidenced no differences for all seminal parameters. In conclusion, benzylpenicillin benzatin added to ACP-106® does not control bacterial growth and does not influence spermatic quality after canine semen cryopreservation.Objetivou-se avaliar o efeito da adição de benzilpenicilina benzatina em diferentes concentrações, sobre a motilidade, morfologia e integridade funcional de membrana do espermatozoide, e o controle do crescimento bacteriano no sêmen canino criopreservado em ACP-106®. Foram utilizados treze ejaculados, avaliados e posteriormente divididos em quatro alíquotas. Cada alíquota foi diluída em ACP-106® com 20% de gema de ovo e quatro concentrações de benzilpenicilina benzatina, de maneira a formar os quatro grupos experimentais: G0 (diluído sem antibiótico; G500 (com 500UI/mL; G1000 (com 1000UI/mL; e G1500 (com 1500UI/mL. Em seguida, as amostras foram congeladas e armazenadas em nitrogênio líquido. Após cerca de uma semana, foram descongeladas e submetidas

  4. Issues in contracting with small minority businesses

    Energy Technology Data Exchange (ETDEWEB)

    Wood, M.T.; Radford, M.L.; Saari, L.M.; Wright, J.

    1986-04-01

    The focus of this investigation was to identify issues central to increasing the involvement of small minority businesses (MBs) in federal or prime contracts with the Department of Energy (DOE), as a foundation for designing a program to assist buyers of contracted goods and services. The approach to determining issues involved interviewing the owners of 15 MBs, representing a range of businesses, and buyers and purchasing officers from three large DOE prime contractors. The interviewees identified issues related to positive working relationships and rated a predetermined set of 27 potential MB-DOE problems regarding their existence and criticalness. The issues identified by MBs were of two broad types. The predominant issues and barriers were associated with their being small businesses. Secondary issues reflected the disadvantaged status of the business (woman and/or minority-owned).

  5. [Hospital performance contract: the Senegalese experience].

    Science.gov (United States)

    Gueye, Mame Abdoulaye; Kopp, Jacques Edouard

    2009-01-01

    In 1998 Senegal launched an ambitious hospital reform program which aimed to transform hospitals into government-owned health enterprises, corporations endowed with a legal entity and autonomy for management. Within this agenda, administrative logic was substituted with the concept of performance management, while simultaneously re-affirming the public service mission that had to remain prominently in the name of the State and public authority. The accompanying measures of the reform implemented by the central level did not produce the expected results in terms of management and quality of care; therefore, the authorities concluded that it was necessary to create more incentives and to link at least a portion of the resources allocated by the State to public hospital establishments in the form of grants which required the demonstration of the achievement of some pre-defined objectives according to a common memorandum of agreement with hospital officials. Thus the idea of contracting was born, an idea which ensued from an expression of political will translated through a national policy document on contracting in the health sector in 2004, but it was also translated through an agreement between the Senegalese government and the World Bank specifically within the framework of budgetary support. The preliminary work necessary to develop these performance contracts, namely, the choice of the domains to be contracted, criteria and performance indicators to be retained, was the subject of a significant process of dialogue with the hospital community. Fifteen contracts were signed during the first quarter of 2006, and then evaluated in July 2007. The results of the evaluations were utilised to substantiate the calculations of the performance subsidy that will be allocated in 2008 to the hospitals having achieved the required eligibility level. Despite the limitations and insufficiencies noted in the contracts' content and in the implementation methods, they had an overall

  6. 24 CFR 888.420 - One-time Contract Rent determination.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false One-time Contract Rent... PERSONS WITH DISABILITIES PROGRAM) SECTION 8 HOUSING ASSISTANCE PAYMENTS PROGRAM-FAIR MARKET RENTS AND CONTRACT RENT ANNUAL ADJUSTMENT FACTORS Retroactive Housing Assistance Payments for Moderate Rehabilitation...

  7. 24 CFR 888.320 - One-time Contract Rent determination.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false One-time Contract Rent... PERSONS WITH DISABILITIES PROGRAM) SECTION 8 HOUSING ASSISTANCE PAYMENTS PROGRAM-FAIR MARKET RENTS AND CONTRACT RENT ANNUAL ADJUSTMENT FACTORS Retroactive Housing Assistance Payments for New Construction...

  8. Simulation des débits moyens mensuels en zone semi-aride par l'analyse en composantes principales (ACP)

    OpenAIRE

    Dechemi, N.; Bermad, A.; Hamriche, A.

    1994-01-01

    La série historique des débits moyens mensuels du barrage de Beni-Bahdel, a été simulée par la méthode de l'analyse en composantes principales (ACP) afin de servir d'entrée aux modèles de gestion. Partant de la structure du modèle de base, plusieurs variantes ont été développées et comparées pour aboutir à un modèle conservant les caractéristiques statistiques de la série historique. L'utilisation de l'analyse en composantes principales dans la simulation des phénomènes aléatoires a donné des...

  9. On CNC commuting contractive tuples

    Indian Academy of Sciences (India)

    The characteristic function has been an important tool for studying completely non-unitary contractions on Hilbert spaces. In this note, we consider completely non-coisometric contractive tuples of commuting operators on a Hilbert space H . We show that the characteristic function, which is now an operator-valued analytic ...

  10. CONTRACT ADMINISTRATIVE TRACKING SYSTEM (CATS)

    Science.gov (United States)

    The Contract Administrative Tracking System (CATS) was developed in response to an ORD NHEERL, Mid-Continent Ecology Division (MED)-recognized need for an automated tracking and retrieval system for Cost Reimbursable Level of Effort (CR/LOE) Contracts. CATS is an Oracle-based app...

  11. Policing Mechanisms in Agricultural Contracts

    Science.gov (United States)

    Wolf, Steven; Hueth, Brent; Ligon, Ethan

    2001-01-01

    In this paper we focus on mechanisms of coordination in agricultural contracts. Our approach is intended to advance understanding of social relations of production and distribution of power in agrofood systems. Through an analysis of contracts between farmers and intermediaries (e.g., processors, shippers, consignment agents) for California fruits…

  12. Contract Training in Community Colleges.

    Science.gov (United States)

    Suchorski, Joan M.

    One of the most significant developments in higher education over the past decade has been the increased linkages between colleges and other organizations and institutions. A prominent and fast-growing form of linkage is contract training. Contract training refers to an arrangement in which a business, a government agency, or a community…

  13. Insights from computational analysis of full-length β-ketoacyl-[ACP] synthase-II cDNA isolated from American and African oil palms

    Science.gov (United States)

    Bhore, Subhash J.; Cha, Thye S.; Amelia, Kassim; Shah, Farida H.

    2014-01-01

    Background: Palm oil derived from fruits (mesocarp) of African oil palm (Elaeis guineensis Jacq. Tenera) and American oil palm (E. oleifera) is important for food industry. Due to high yield, Elaeis guineensis (Tenera) is cultivated on commercial scale, though its oil contains high (~54%) level of saturated fatty acids. The rate-limiting activity of beta-ketoacyl-[ACP] synthase-II (KAS-II) is considered mainly responsible for the high (44%) level of palmitic acid (C16:0) in the oil obtained from E. guineensis. Objective: The objective of this study was to annotate KAS-II cDNA isolated from American and African oil palms. Materials and Methods: The full-length E. oleifera KAS-II (EoKAS-II) cDNA clone was isolated using random method of gene isolation. Whereas, the E. guineensis KAS-II (EgTKAS-II) cDNA was isolated using reverse transcriptase polymerase chain reaction (RT-PCR) technique; and missing ends were obtained by employing 5’and 3’ RACE technique. Results: The results show that EoKAS-II and EgTKAS-II open reading frames (ORFs) are of 1689 and 1721 bp in length, respectively. Further analysis of the both EoKAS-II and EgTKAS-II predicted protein illustrates that they contains conserved domains for ‘KAS-I and II’, ‘elongating’ condensing enzymes, ‘condensing enzymes super-family’, and ‘3-oxoacyl-[ACP] synthase II’. The predicted protein sequences shows 95% similarity with each other. Consecutively, the three active sites (Cys, His, and His) were identified in both proteins. However, difference in positions of two active Histidine (His) residues was noticed. Conclusion: These insights may serve as the foundation in understanding the variable activity of KAS-II in American and African oil palms; and cDNA clones could be useful in the genetic engineering of oil palms. PMID:24678202

  14. Deposition of stearate-oleate rich seed fat in Mangifera indica is mediated by a FatA type acyl-ACP thioesterase.

    Science.gov (United States)

    Bhattacharjee, Ashish; Ghosh, Santosh K; Neogi, Krishnakali; Aich, Aniruddha; Willard, Belinda; Kinter, Michael; Sen, Soumitra K; Ghosh, Dolly; Ghosh, Sudhamoy

    2011-02-01

    Although the mechanism of accumulation of C8-C16 saturated fatty acids in seed oils has been well-studied, the control of stearic (C18:0) acid deposition in high stearate seed fat is still unclear. We investigated the mechanism that regulates high level of stearate and oleate (C18:1) accumulation in mango (Mangifera indica) seeds during its development, and examined the seed plastid extracts for induction of any specialized fatty acyl-ACP thioesterase (Fat) that may control this high level of deposition. Though the specificity of the Fat enzymes does not account directly for the fatty acid composition of mango seeds, our result suggested that an induced synthesis of a FatA type of thioesterase could be responsible for the high content of oleate and stearate in its seed fat. The major thioesterase from developing seed kernel was purified to near homogeneity, and characterized as a heat-labile, dimeric, neutral protein with relative substrate specificity of 100:35:1.8 towards oleoyl-, stearoyl- and palmitoyl-ACP, respectively. This enzyme was confirmed as Mi FatA by mass spectrometric analysis. Additionally, a heat-stable FatB type enzyme (Mi FatB) was also partially purified, with relative substrate specificity for the same substrates as 9:8.5:100, respectively. Mi FatA is an enzyme of great biotechnological interest because of its involvement in the regulation of stearate rich seed fat in mango. Copyright © 2010 Elsevier Ltd. All rights reserved.

  15. Choreography Synthesis as Contract Agreement

    Directory of Open Access Journals (Sweden)

    Julien Lange

    2013-10-01

    Full Text Available We propose a formal model for distributed systems, where each participant advertises its requirements and obligations as behavioural contracts, and where multiparty sessions are started when a set of contracts allows to synthesise a choreography. Our framework is based on the CO2 calculus for contract-oriented computing, and borrows concepts and results from the session type literature. It supports sessions where the number of participants is not determined beforehand, and keeps CO2's ability to rule out participants that are culpable if contracts are not fulfilled at runtime. We show that we have progress and session fidelity in CO2, as a result of the honesty of participants — i.e., their ability to always adhere to their contracts.

  16. Contracting and Performance in Agencies

    DEFF Research Database (Denmark)

    Bjørnholt, Bente; Houlberg Salomonsen, Heidi; Rennison, Betina Wolfgang

    , documentary and interview data. To measure the degree of performance as the degree of goal attainment, all agency contracts for 2008 as well as the subsequent ‘enterprise accounts’ defining the goal attainment have been collected. There were 62 agencies in 2008, 58 of which had a contract. Goal attainment......As part of New Public Management (NPM), contracting represents a supplement to the traditional hierarchical and rule-based managing of relations between actors in order to improve performance (Fortin and van Hassel 2000; Greve and Ejersbo 2002; Drewry et al. 2005; Verhoest 2005). To various degrees...... contracts combine some degree of managerial autonomy and influence on goal setting in return for a consistent and congruent system of control and monitoring. Internal contracts are often finalized within the ‘shadow of hierarchy’ between mutually dependent parties in a long-term, co-operation-based...

  17. Mechanobiology of lymphatic contractions.

    Science.gov (United States)

    Munn, Lance L

    2015-02-01

    The lymphatic system is responsible for controlling tissue fluid pressure by facilitating flow of lymph (i.e. the plasma and cells that enter the lymphatic system). Because lymph contains cells of the immune system, its transport is not only important for fluid homeostasis, but also immune function. Lymph drainage can occur via passive flow or active pumping, and much research has identified the key biochemical and mechanical factors that affect output. Although many studies and reviews have addressed how tissue properties and fluid mechanics (i.e. pressure gradients) affect lymph transport [1-3] there is less known about lymphatic mechanobiology. As opposed to passive mechanical properties, mechanobiology describes the active coupling of mechanical signals and biochemical pathways. Lymphatic vasomotion is the result of a fascinating system affected by mechanical forces exerted by the flowing lymph, including pressure-induced vessel stretch and flow-induced shear stresses. These forces can trigger or modulate biochemical pathways important for controlling the lymphatic contractions. Here, I review the current understanding of lymphatic vessel function, focusing on vessel mechanobiology, and summarize the prospects for a comprehensive understanding that integrates the mechanical and biomechanical control mechanisms in the lymphatic system. Copyright © 2015 Elsevier Ltd. All rights reserved.

  18. INFINITY construction contract signed

    Science.gov (United States)

    2010-01-01

    Key state and community leaders celebrated April 6 with the signing of a construction contract for the state-of-the-art INFINITY Science Center planned near John C. Stennis Space Center in south Mississippi. Gulfport Mayor George Schloegel (l to r), chair of non-profit INFINITY Science Center Inc., was joined for the signing ceremony at the Hancock Bank in Gulfport by Virginia Wagner, sister of late Hancock Bank President Leo Seal Jr.; and Roy Anderson III, president and CEO of Roy Anderson Corp. Seal was the first chair of INFINITY Science Center Inc., which has led in development of the project. Roy Anderson Corp. plans to begin construction on the 72,000-square-foot, $28 million science and education center in May. The Mississippi Department of Transportation (MDOT) also is set to begin construction of a $2 million access road to the new center. The April 6 ceremony was attended by numerous officials, including former Stennis Space Center Directors Jerry Hlass and Roy Estess; Mississippi Senate President Pro Tempore Billy Hewes, R-Gulfport; Mississippi Rep. Diane Peranich, D-Pass Christian; and MDOT Southern District Commissioner Wayne Brown.

  19. [Ulysses contract in psychiatry].

    Science.gov (United States)

    Daverio, Andrea; Piazzi, Gioia; Saya, Anna

    2017-01-01

    Over the last twenty years we have witnessed a growing focus on the rights of the ill people. The debate on informed consent and a new redefinition of the therapeutic relationship is constantly evolving. With this article, we propose a critical literature review of the so-called "Ulysses contract" or "psychiatric advance directives". It refers to the will that a subject expresses in writing, or orally, about the treatments he or she wishes or does not wish to be subject to if the time comes when it may be impossible to express his/her consent. This can especially occur in those with psychiatric disorders with serious clinical involvement and remitting-relapse (typically bipolar disorder, but also chronic delusional disorders and schizophrenia). In this context, the question is whether during intercritical periods the patient may or may not leave instructions to their care-givers. This aspect opens up to a series of interdisciplinary problems. In this article, we want to show the complexity of this debate from a clinical, ethical, legal and psychodynamic point of view, emphasizing the strengths and the major criticisms of the psychiatric advance directives for each area.

  20. 48 CFR 1516.307 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ...-reimbursement contracts when an anticipatory cost letter has been issued on the project. (b) The Contracting... such a provision would be detrimental to ensuring proper contract performance. (c) The Contracting... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Contract clauses. 1516.307...

  1. Ontologies for commitment-based smart contracts

    NARCIS (Netherlands)

    de Kruijff, Joost; Weigand, Hans; Panetto, H; Debruyne, C.; Gaaloul, W.; Papazoglou, M.; Paschke, A.; Ardagna, C.A.; Meersman, R.

    2017-01-01

    Smart contracts gain rapid exposure since the inception of blockchain technology. Yet there is no unified ontology for smart contracts. Being categorized as coded contracts or substitutes of conventional legal contracts, there is a need to reduce the conceptual ambiguity of smart contracts. We

  2. 48 CFR 811.503 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause. 811.503... ACQUISITION PLANNING DESCRIBING AGENCY NEEDS Liquidated Damages 811.503 Contract clause. When the contracting... contracting officer must include the clause in 852.211-74, Liquidated damages, in the contract. ...

  3. 48 CFR 837.403 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause. 837.403... OF CONTRACTING SERVICE CONTRACTING Nonpersonal Health Care Services 837.403 Contract clause. The contracting officer shall insert the clause at 852.237-7, Indemnification and medical liability insurance, in...

  4. Mission and Installation Contracting Command Services Acquisition: Empirical Analysis of Army Service Contract Management Practices

    OpenAIRE

    Michelle Ramos; Joshua Nabors

    2011-01-01

    Sponsored Report (for Acquisition Research Program) The overall purpose of this research is to develop a comprehensive understanding of how the Army Mission and Installation Contracting Command (MICC) manages the acquisition of services. The specific objective of the project is to build on the understanding developed in prior research projects and to identify the factors that promote or obstruct the use of best practices in acquisition management and influence the efficiency and effective...

  5. University contracts summary book

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-08-01

    The principal objectives of the Fossil Energy Program are to seek new ideas, new data, fundamental knowledge that will support the ongoing programs, and new processes to better utilize the nation's fossil energy resources with greater efficiency and environmental acceptability. Toward this end, the Department of Energy supports research projects conducted by universities and colleges to: Ensure a foundation for innovative technology through the use of the capabilities and talents in our academic institutions; provide an effective, two-way channel of communication between the Department of Energy and the academic community; and ensure that trained technical manpower is developed to carry out basic and applied research in support of DOE's mission. Fossil Energy's university activities emphasize the type of research that universities can do best - research to explore the potential of novel process concepts, develop innovative methods and materials for improving existing processes, and obtain fundamental information on the structure of coal and mechanisms of reactions of coal, shale oil, and other fossil energy sources. University programs are managed by different Fossil Energy technical groups; the individual projects are described in greater detail in this book. It is clear that a number of research areas related to the DOE Fossil Energy Program have been appropriate for university involvement, and that, with support from DOE, university scientific and technical expertise can be expected to continue to play a significant role in the advancement of fossil energy technology in the years to come.

  6. Food and drink serving contract

    Directory of Open Access Journals (Sweden)

    Veselinović Janko

    2012-01-01

    Full Text Available Food and drink catering service is almost as old as the civilization itself. Even though this vocation is a part of the catering activity, Serbian law does not foresee this contract section as personalized. Key legal sources for this kind of contract are business customs. Food and drink serving contract is a mixed-type contract and its legal nature is very interesting due to its complexity. Specific for this contract is the fact that it is not an ordinary service, but also an activity which requires a degree of culinary skills, knowledge of customs of other nations, as well as other skills. The very category of a good professional in business economy / hospitality industry is very dynamic, as it needs to be evaluated according to all given circumstances, which may be rather unpredictable. By considering the legal nature, but also the rights and obligations of the contracting parties, we tried to point to the questions that require a special attention. Legal sources that indirectly refer to food and drink serving contracts were taken into account. Apart from the Law on Obligatory Relations, we also considered here the Law on Tourism also pointing to the comparative law and jurisprudence.

  7. Analysis of the 314th contracting squadrons contract management capability using the Contract Management Maturity Model (CMMM)

    OpenAIRE

    Jackson, Carl J.

    2007-01-01

    MBA Professional Report This research project provides an assessment of the contract management capability of the 314th Contracting Squadron located at Little Rock Air Force Base, Arkansas. The assessment uses a questionnaire covering the six phases of the contract management process. The purpose of this research project is to analyze the 314th Contracting Squadron contracting processes and requirement target areas for improvement efforts by the application of the Contract Management M...

  8. CONTRACT FOLLOW-UP

    CERN Multimedia

    Technical Training; Tel. 74924

    2000-01-01

    CFU is the program developed by AS division to follow the life cycle of procurement of supply and services for large amounts. The course is free of charge but registration is requested. Sessions scheduled: 27.11.2000 12.03.2001 15.12.2000 09.04.2001 12.01.2001 07.05.2001 12.02.2001 11.06.2001

  9. 48 CFR 2446.710 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... CONTRACT MANAGEMENT QUALITY ASSURANCE Warranties 2446.710 Contract clauses. (c)(1) The contracting officer may include a clause substantially the same as FAR 52.246-19, Warranty of Systems and Equipment under...

  10. Bottomland Hardwood Planting: Example Contract Specifications

    National Research Council Canada - National Science Library

    Humprey, Monica

    2002-01-01

    This technical note provides an example of contract specifications that can be used as a template by USACE biologists, engineers, or contracting officers for contracting the planting of bottomland hardwood (BLH) seedlings...

  11. 78 FR 11699 - International Mail Contract

    Science.gov (United States)

    2013-02-19

    ... International Mail Contract AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: The Commission is... entered into an additional International Business Reply Service (IBRS) Competitive Contract 3 negotiated... Equivalent International Business Reply Service Competitive Contract 3 Negotiated Service Agreement, February...

  12. 78 FR 11237 - International Mail Contract

    Science.gov (United States)

    2013-02-15

    ... International Mail Contract AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: The Commission is noticing a recent Postal Service filing concerning an additional Global Reseller Expedited Package Contract... entered into an additional Global Reseller Expedited Package Contracts 1 negotiated service agreement...

  13. 77 FR 54937 - International Mail Postal Contract

    Science.gov (United States)

    2012-09-06

    ... COMMISSION International Mail Postal Contract AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY... (2) asks the Commission to include the new contract within the International Business Reply Service... Functionally Equivalent International Business Reply Service Competitive Contract 3 Negotiated Settlement...

  14. Utility Energy Services Contracts: Enabling Documents

    Energy Technology Data Exchange (ETDEWEB)

    None

    2009-05-01

    Utility Energy Services Contracts: Enabling Documents provides materials that clarify the authority for Federal agencies to enter into utility energy services contracts (UESCs), as well as sample documents and resources to ease utility partnership contracting.

  15. Predicting Commitment Forms From Psychological Contract Breach ...

    African Journals Online (AJOL)

    Measures to be taken by management at equilibrating employees' psychological contract breach, reducing labour turnover and increasing commitment are suggested. Keywords: Mergers, acquisition, Commitment, psychological contract breach, and psychological contract violation, human resource management.

  16. 40 CFR 35.970 - Contract enforcement.

    Science.gov (United States)

    2010-07-01

    ... STATE AND LOCAL ASSISTANCE Grants for Construction of Treatment Works-Clean Water Act § 35.970 Contract... technical or legal involvement in any contract dispute will not make EPA a party to any contract entered...

  17. 24 CFR 983.206 - HAP contract amendments (to add or substitute contract units).

    Science.gov (United States)

    2010-04-01

    ... substitute contract units). 983.206 Section 983.206 Housing and Urban Development Regulations Relating to... Contract § 983.206 HAP contract amendments (to add or substitute contract units). (a) Amendment to substitute contract units. At the discretion of the PHA and subject to all PBV requirements, the HAP contract...

  18. Smooth Sailing with Contract Services.

    Science.gov (United States)

    Fickes, Michael

    2001-01-01

    Discusses how to make the contract services relationship work smoothly for educational facilities. Covers topics of food, child care, and transportation services, along with a brief explanation of the benefits of outsourcing on-campus amenities. (GR)

  19. Next Indefinite Contract review exercise

    CERN Multimedia

    2013-01-01

    Dear Colleagues, We are pleased to inform you that the 2013 LD2IC exercise (selection process for the conversion of limited-duration contracts to indefinite contracts) was officially launched last week.  The vacancy notices for posts opened with a view to the award of indefinite contracts will be published on 9 August 2013 for a period of four weeks (until 8 September 2013). The CERN Contract Review Boards (candidate interviews) will be held between the end of September and mid-November. The LD to IC procedure, Frequently Asked Questions and a calendar for the exercise are now available in the Admin e-guide. In addition, general information sessions on the procedure will be organised for candidates on the following dates: Information on the location of these sessions will be provided in due course on the CERN announcements page. HR Department

  20. Framework for Structuring Procurement Contracts

    Directory of Open Access Journals (Sweden)

    Lena Borg

    2014-12-01

    Full Text Available The aim of this paper is to propose a new framework for structuring contract types and payment methods. Concerning procurement contracts, the first important new feature of this framework is a stepwise structure with three main steps in the contract design: (1 what will be procured—should the contract only include construction, or should it include both construction and operation/maintenance (2 who will do the detailed design of the premise and (3 how many contractors will the client use? The second important new feature of this framework is that both step 2 and step 3 include a continuum of alternatives. Concerning payment methods, the new framework is primarily based on how the specific risks of the project are shared. These frameworks can be useful for policy formulation in that they can help to avoid some problematic ways of formulating policies.

  1. Multifamily Assistance Section 8 Contracts

    Data.gov (United States)

    Department of Housing and Urban Development — he information regarding the Multifamily Assistance and Section 8 contracts, and properties is being furnished for the convenience of interested parties. The...

  2. Non-renewal of contracts

    CERN Multimedia

    Association du personnel

    2007-01-01

    A new illegal practice is appearing in certain sectors of the Organization: the non-renewal of renewable three-year limited-duration (LD) contracts, despite a more than satisfactory performance and an obvious commitment to the Organization.

  3. Construction contracts law and management

    CERN Document Server

    Hughes, Will; Murdoch, John

    2015-01-01

    The fifth edition of this bestselling textbook has been thoroughly revised to provide the most up-to-date and comprehensive coverage of the legislation, administration and management of construction contracts. It now includes comparisons of working with JCT, NEC3, and FIDIC contracts throughout. Introducing this topic at the core of construction law and management, this book provides students with a one-stop reference on construction contracts. Significant new material covers: procurement tendering developments in dispute settlement commentary on all key legislation, case law and contract amendments In line with new thinking in construction management research, this authoritative guide is essential reading for every construction undergraduate and an extremely useful source of reference for practitioners.

  4. Determinants of Service Contract Outcomes

    Science.gov (United States)

    2011-04-30

    limited to applications of service quality in business-to-consumer (B2C) contexts. The five dimensions of service quality do not always fit B2B ...Buyers of customer-defined B2B services often state service expectations in requirement documents that are incorporated into contracts. Within public...centrality of relational exchange, any study of B2B exchange should include the effects of relational norms. When contracting for services, proper

  5. 7 CFR 1780.61 - Construction contracts.

    Science.gov (United States)

    2010-01-01

    ... AGRICULTURE (CONTINUED) WATER AND WASTE LOANS AND GRANTS Planning, Designing, Bidding, Contracting... will be obtained prior to their use. (b) Contract review and concurrence. The owner's attorney will...

  6. Covenant Violations and Dynamic Loan Contracting

    DEFF Research Database (Denmark)

    Freudenberg, Felix; Imbierowicz, Björn; Saunders, Anthony

    2017-01-01

    This paper examines the dynamic allocation of control rights in private debt contracts of firms. We show that a covenant violation in the prior loan contract implies a stigma for borrowers which results in stricter loan contract terms in subsequent new loan contracts. Our analyses reject potentia......This paper examines the dynamic allocation of control rights in private debt contracts of firms. We show that a covenant violation in the prior loan contract implies a stigma for borrowers which results in stricter loan contract terms in subsequent new loan contracts. Our analyses reject...

  7. 48 CFR 39.103 - Modular contracting.

    Science.gov (United States)

    2010-10-01

    ... section implements Section 5202, Incremental Acquisition of Information Technology, of the Clinger-Cohen... circumstances (e.g., indefinite delivery, indefinite quantity contracts, single contract with options...

  8. Management of Contracts for F110 Engine Procurements

    National Research Council Canada - National Science Library

    Granetto, Paul

    2001-01-01

    .... The Administrative Contracting Office, Defense Contract Management Agency at the General Electric Aircraft Engine plant in Cincinnati, Ohio, was responsible for contract administration functions after contract award.

  9. Medicare HMO risk contracts: background, problems, and prognosis.

    Science.gov (United States)

    Krasner, W L; Goff, A R

    1987-01-01

    Major changes in the Medicare program mandated by the Tax Equity and Fiscal Responsibility Act of 1982 (TEFRA) became effective in 1985 and included the introduction of a capitated system for reimbursing health maintenance organizations (HMOs) for health care services provided to enrolled Medicare beneficiaries. Risk contracts with HMOs allowed the enrollment of some 900,000 individuals by May of 1987. The program has witnessed some variability in results including the Health Care Financing Administration's (HCFA's) May 1987 termination of its risk contract with International Medical Centers, Inc., a Florida-based HMO serving 150,000 subscribers, because of a number of problems, including quality of care. Recent Administration proposals would create a "private health plan option" (PHPO) with capitation and managed care provisions for all Medicare beneficiaries. This proposal would allow employers (and other entities not eligible for TEFRA risk contracts) to provide group health benefits to retirees with costs reimbursed on a capitated basis.

  10. Medicare program; prospective payment system for federally qualified health centers; changes to contracting policies for rural health clinics; and changes to Clinical Laboratory Improvement Amendments of 1988 enforcement actions for proficiency testing referral. Final rule with comment period.

    Science.gov (United States)

    2014-05-02

    This final rule with comment period implements methodology and payment rates for a prospective payment system (PPS) for federally qualified health center (FQHC) services under Medicare Part B beginning on October 1, 2014, in compliance with the statutory requirement of the Affordable Care Act. In addition, it establishes a policy which allows rural health clinics (RHCs) to contract with nonphysician practitioners when statutory requirements for employment of nurse practitioners and physician assistants are met, and makes other technical and conforming changes to the RHC and FQHC regulations. Finally, this final rule with comment period implements changes to the Clinical Laboratory Improvement Amendments (CLIA) regulations regarding enforcement actions for proficiency testing (PT) referrals.

  11. Medicare Program; End-Stage Renal Disease Prospective Payment System, Coverage and Payment for Renal Dialysis Services Furnished to Individuals With Acute Kidney Injury, End-Stage Renal Disease Quality Incentive Program, Durable Medical Equipment, Prosthetics, Orthotics and Supplies Competitive Bidding Program Bid Surety Bonds, State Licensure and Appeals Process for Breach of Contract Actions, Durable Medical Equipment, Prosthetics, Orthotics and Supplies Competitive Bidding Program and Fee Schedule Adjustments, Access to Care Issues for Durable Medical Equipment; and the Comprehensive End-Stage Renal Disease Care Model. Final rule.

    Science.gov (United States)

    2016-11-04

    This rule updates and makes revisions to the End-Stage Renal Disease (ESRD) Prospective Payment System (PPS) for calendar year 2017. It also finalizes policies for coverage and payment for renal dialysis services furnished by an ESRD facility to individuals with acute kidney injury. This rule also sets forth requirements for the ESRD Quality Incentive Program, including the inclusion of new quality measures beginning with payment year (PY) 2020 and provides updates to programmatic policies for the PY 2018 and PY 2019 ESRD QIP. This rule also implements statutory requirements for bid surety bonds and state licensure for the Durable Medical Equipment, Prosthetics, Orthotics, and Supplies (DMEPOS) Competitive Bidding Program (CBP). This rule also expands suppliers' appeal rights in the event of a breach of contract action taken by CMS, by revising the appeals regulation to extend the appeals process to all types of actions taken by CMS for a supplier's breach of contract, rather than limit an appeal for the termination of a competitive bidding contract. The rule also finalizes changes to the methodologies for adjusting fee schedule amounts for DMEPOS using information from CBPs and for submitting bids and establishing single payment amounts under the CBPs for certain groupings of similar items with different features to address price inversions. Final changes also are made to the method for establishing bid limits for items under the DMEPOS CBPs. In addition, this rule summarizes comments on the impacts of coordinating Medicare and Medicaid Durable Medical Equipment for dually eligible beneficiaries. Finally, this rule also summarizes comments received in response to a request for information related to the Comprehensive ESRD Care Model and future payment models affecting renal care.

  12. An empirical analysis of smart contracts: platforms, applications, and design patterns

    OpenAIRE

    Bartoletti, Massimo; Pompianu, Livio

    2017-01-01

    Smart contracts are computer programs that can be consistently executed by a network of mutually distrusting nodes, without the arbitration of a trusted authority. Because of their resilience to tampering, smart contracts are appealing in many scenarios, especially in those which require transfers of money to respect certain agreed rules (like in financial services and in games). Over the last few years many platforms for smart contracts have been proposed, and some of them have been actually...

  13. Dynamic Dispatch for Method Contracts through Abstract Predicates

    NARCIS (Netherlands)

    Mostowski, Wojciech; Ulbrich, Mattias

    2015-01-01

    Dynamic method dispatch is a core feature of object-oriented programming by which the executed implementation for a polymorphic method is only chosen at runtime. In this paper, we present a specification and verification methodology which extends the concept of dynamic dispatch to design-by-contract

  14. 24 CFR 1715.4 - Contract requirements and revocation.

    Science.gov (United States)

    2010-04-01

    ... HOUSING AND URBAN DEVELOPMENT (INTERSTATE LAND SALES REGISTRATION PROGRAM) PURCHASERS' REVOCATION RIGHTS... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Contract requirements and revocation. 1715.4 Section 1715.4 Housing and Urban Development Regulations Relating to Housing and Urban...

  15. 76 FR 2706 - Notice of Extension of Concession Contracts

    Science.gov (United States)

    2011-01-14

    ... Park. Specialists of Florida, Inc. GUIS001-03 Dudley Food and Gulf Islands National Seashore. Beverage... NATIONAL PARK SERVICE Notice of Extension of Concession Contracts AGENCY: National Park Service, Interior.... Pendry, Chief, Commercial Services Program, National Park Service, 1201 Eye Street, NW., 11th Floor...

  16. Next Indefinite Contract review exercise

    CERN Multimedia

    HR Department

    2015-01-01

    Dear Colleagues, We are pleased to inform you that the 2015 LD2IC exercise (selection process for the conversion of limited-duration contracts into indefinite contracts) has been officially launched. The vacancy notices for posts opened with a view to the award of indefinite contracts will be published on 3 August 2015 for a period of four weeks (until 31 August 2015). The CERN Contract Review Boards (candidate interviews) will be held between the end of September and mid-November. The LD to IC procedure, Frequently Asked Questions (FAQ) and a calendar for the exercise are now available in the Admin e-guide. In addition, general information sessions on the procedure will be organised for candidates on the following dates: We would like to remind you that all staff members holding a limited-duration contract who have successfully completed their probation period at the time of application and who meet the eligibility criteria in the vacancy notices (VNs) are eligible to apply for posts for the award of a...

  17. Next Indefinite Contract review exercise

    CERN Multimedia

    2015-01-01

    Dear Colleagues, We are pleased to inform you that the 2015 LD2IC exercise (selection process for the conversion of limited-duration contracts into indefinite contracts) has been officially launched. The vacancy notices for posts opened with a view to the award of indefinite contracts will be published on 3 August 2015 for a period of four weeks (until 31 August 2015). The CERN Contract Review Boards (candidate interviews) will be held between the end of September and mid-November. The LD to IC procedure, Frequently Asked Questions (FAQ) and a calendar for the exercise are now available in the Admin e-guide. In addition, general information sessions on the procedure will be organised for candidates on the following dates: We would like to remind you that all staff members holding a limited-duration contract who have successfully completed their probation period at the time of application and who meet the eligibility criteria in the vacancy notices (VNs) are eligible to apply for posts for the awa...

  18. 48 CFR 970.1504 - Contract pricing.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract pricing. 970.1504 Section 970.1504 Federal Acquisition Regulations System DEPARTMENT OF ENERGY AGENCY SUPPLEMENTARY REGULATIONS DOE MANAGEMENT AND OPERATING CONTRACTS Contracting by Negotiation 970.1504 Contract pricing. ...

  19. 29 CFR 96.62 - Contracts.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Contracts. 96.62 Section 96.62 Labor Office of the Secretary of Labor AUDIT REQUIREMENTS FOR GRANTS, CONTRACTS, AND OTHER AGREEMENTS Appeals § 96.62 Contracts. (a... audit, the contractor may appeal the final determination to the DOL Board of Contract Appeals, pursuant...

  20. 48 CFR 546.710 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... Section 546.710 Federal Acquisition Regulations System GENERAL SERVICES ADMINISTRATION CONTRACT MANAGEMENT QUALITY ASSURANCE Warranties 546.710 Contract clause. The Contracting officer shall insert the clause at 552.246-77, Additional Contract Warranty Provisions for Supplies of a Noncomplex Nature, when using...

  1. 48 CFR 846.710 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... Section 846.710 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS CONTRACT MANAGEMENT QUALITY ASSURANCE Warranties 846.710 Contract clauses. The contracting officer shall insert the clause at FAR 52.246-21, Warranty of Construction, in solicitations and contracts for construction that are...

  2. 43 CFR 2.53 - Government contracts.

    Science.gov (United States)

    2010-10-01

    ... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Government contracts. 2.53 Section 2.53 Public Lands: Interior Office of the Secretary of the Interior RECORDS AND TESTIMONY; FREEDOM OF INFORMATION ACT Privacy Act § 2.53 Government contracts. (a) Required contract provisions. When a contract...

  3. 77 FR 71458 - New International Mail Contract

    Science.gov (United States)

    2012-11-30

    ... New International Mail Contract AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: The... Expedited Package Contracts 1. This document invites public comments on the request and addresses several... additional Global Reseller Expedited Package (GREP) contract (Contracts 1).\\1\\ It seeks to have the instant...

  4. 48 CFR 29.401 - Domestic contracts.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Domestic contracts. 29.401 Section 29.401 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL CONTRACTING REQUIREMENTS TAXES Contract Clauses 29.401 Domestic contracts. ...

  5. 7 CFR 1753.11 - Contract amendments.

    Science.gov (United States)

    2010-01-01

    ...) The amendment alters the terms and conditions of the contract or changes the scope of the project... contract to require a contractor's performance bond. This would occur when a contract that is executed in... 7 Agriculture 11 2010-01-01 2010-01-01 false Contract amendments. 1753.11 Section 1753.11...

  6. 48 CFR 747.507 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 747.507 Section 747.507 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT CONTRACT MANAGEMENT TRANSPORTATION Ocean Transportation by U.S.-Flag Vessels 747.507 Contract clauses. Contracting...

  7. 48 CFR 904.7201 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause. 904.7201... MATTERS Public Affairs 904.7201 Contract clause. The contracting officer shall insert the clause at 952.204-75, Public Affairs, in solicitations and contracts that require the contractor to release...

  8. 48 CFR 1336.609 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 1336.609 Section 1336.609 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE SPECIAL CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS Architect-Engineer Services 1336.609 Contract...

  9. 48 CFR 53.111 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 2 2010-10-01 2010-10-01 false Contract clause. 53.111... AND FORMS FORMS General 53.111 Contract clause. Contracting officers shall insert the clause at 52.253-1, Computer Generated Forms, in solicitations and contracts that require the contractor to submit...

  10. 48 CFR 871.212 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 871.212... Rehabilitation and Employment Service 871.212 Contract clauses. Contracting officers must use the following clauses, as appropriate, in solicitations and contracts for vocational rehabilitation and employment...

  11. 48 CFR 811.404 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause. 811.404... ACQUISITION PLANNING DESCRIBING AGENCY NEEDS Delivery or Performance Schedules 811.404 Contract clause. When delivery is required by or on a particular date for f.o.b. destination contracts, the contracting officer...

  12. 48 CFR 833.215 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause. 833.215 Section 833.215 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS GENERAL CONTRACTING REQUIREMENTS PROTESTS, DISPUTES, AND APPEALS Disputes and Appeals 833.215 Contract clause. The contracting...

  13. 48 CFR 1339.107 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 1339.107... CONTRACTING ACQUISITION OF INFORMATION TECHNOLOGY General 1339.107 Contract clauses. Insert clause 1352.239-70, Software License Addendum, in all contracts when the primary purpose is to purchase new software licenses...

  14. 48 CFR 1443.205 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 1443.205 Section 1443.205 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR CONTRACT MANAGEMENT CONTRACT MODIFICATIONS Change Orders 1443.205 Contract clauses. BPCs may establish procedures, when...

  15. 48 CFR 903.971 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clause. 903.971... Contract clause. The contracting officer shall insert the clause at 952.203-70, Whistleblower Protection for Contractor Employees, in contracts that involve work to be done on behalf of DOE directly related...

  16. 48 CFR 1427.303 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 1427.303 Section 1427.303 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR GENERAL CONTRACTING REQUIREMENTS PATENTS, DATA, AND COPYRIGHTS Patent Rights Under Government Contracts. 1427.303 Contract clauses...

  17. 48 CFR 745.106 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 745.106 Section 745.106 Federal Acquisition Regulations System AGENCY FOR INTERNATIONAL DEVELOPMENT CONTRACT MANAGEMENT GOVERNMENT PROPERTY General 745.106 Contract clauses. (a) The contracting officer shall insert the...

  18. 24 CFR 242.52 - Construction contracts.

    Science.gov (United States)

    2010-04-01

    ...; a construction management contract with a guaranteed maximum price, the final costs of which are... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Construction contracts. 242.52... MORTGAGE INSURANCE FOR HOSPITALS Construction § 242.52 Construction contracts. (a) Awarding of contract. A...

  19. Genetic modifications of Mecr reveal a role for mitochondrial 2-enoyl-CoA/ACP reductase in placental development in mice.

    Science.gov (United States)

    Nair, Remya R; Kerätär, Juha M; Autio, Kaija J; Masud, Ali J; Finnilä, Mikko A J; Autio-Harmainen, Helena I; Miinalainen, Ilkka J; Nieminen, Pentti A; Hiltunen, J Kalervo; Kastaniotis, Alexander J

    2017-06-01

    Mitochondrial fatty acid synthesis (mtFAS) is an underappreciated but highly conserved metabolic process, indispensable for mitochondrial respiration. It was recently reported that dysfunction of mtFAS causes childhood onset of dystonia and optic atrophy in humans (MEPAN). To study the role of mtFAS in mammals, we generated three different mouse lines with modifications of the Mecr gene, encoding mitochondrial enoyl-CoA/ACP reductase (Mecr). A knock-out-first type mutation, relying on insertion of a strong transcriptional terminator between the first two exons of Mecr, displayed embryonic lethality over a broad window of time and due to a variety of causes. Complete removal of exon 2 or replacing endogenous Mecr by its functional prokaryotic analogue fabI (Mecrtm(fabI)) led to more consistent lethality phenotypes and revealed a hypoplastic placenta. Analyses of several mitochondrial parameters indicate that mitochondrial capacity for aerobic metabolism is reduced upon disrupting mtFAS function. Further analysis of the synthetic Mecrtm(fabI) models disclosed defects in development of placental trophoblasts consistent with disturbed peroxisome proliferator-activated receptor signalling. We conclude that disrupted mtFAS leads to deficiency in mitochondrial respiration, which lies at the root of the observed pantropic effects on embryonic and placental development in these mouse models. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  20. Aqueous Molecular Dynamics Simulations of the M. tuberculosis Enoyl-ACP Reductase-NADH System and Its Complex with a Substrate Mimic or Diphenyl Ethers Inhibitors

    Directory of Open Access Journals (Sweden)

    Camilo Henrique da Silva Lima

    2015-10-01

    Full Text Available Molecular dynamics (MD simulations of 12 aqueous systems of the NADH-dependent enoyl-ACP reductase from Mycobacterium tuberculosis (InhA were carried out for up to 20–40 ns using the GROMACS 4.5 package. Simulations of the holoenzyme, holoenzyme-substrate, and 10 holoenzyme-inhibitor complexes were conducted in order to gain more insight about the secondary structure motifs of the InhA substrate-binding pocket. We monitored the lifetime of the main intermolecular interactions: hydrogen bonds and hydrophobic contacts. Our MD simulations demonstrate the importance of evaluating the conformational changes that occur close to the active site of the enzyme-cofactor complex before and after binding of the ligand and the influence of the water molecules. Moreover, the protein-inhibitor total steric (ELJ and electrostatic (EC interaction energies, related to Gly96 and Tyr158, are able to explain 80% of the biological response variance according to the best linear equation, pKi = 7.772 − 0.1885 × Gly96 + 0.0517 × Tyr158 (R2 = 0.80; n = 10, where interactions with Gly96, mainly electrostatic, increase the biological response, while those with Tyr158 decrease. These results will help to understand the structure-activity relationships and to design new and more potent anti-TB drugs.

  1. Modulation of Medium-Chain Fatty Acid Synthesis in Synechococcus sp. PCC 7002 by Replacing FabH with a Chaetoceros ketoacyl-ACP synthase

    Directory of Open Access Journals (Sweden)

    Huiya eGu

    2016-05-01

    Full Text Available The isolation or engineering of algal cells synthesizing high levels of medium-chain fatty acids (MCFAs is attractive to mitigate the high clouding point of longer chain fatty acids in algal based biodiesel. To develop a more informed understanding of MCFA synthesis is photosynthetic microorganisms, we isolated several algae from Great Salt Lake and screened this collection for MCFA accumulation to identify strains naturally accumulating high levels of MCFA. A diatom, Chaetoceros sp. GSL56, accumulated particularly high levels of C14 (up to 40%, with the majority of C14 fatty acids (~2/3 allocated in triacylglycerols. Using whole cell transcriptome sequencing and de novo assembly, putative genes encoding fatty acid synthesis enzymes were identified. Enzymes from this Chaetoceros sp. were expressed in the cyanobacterium Synechococcus sp. PCC 7002 to validate gene function and to determine whether eukaryotic enzymes lacking bacteria evolutionary control mechanisms could be used to improve MCFA production in this promising production strains. Replacement of the Synechococcus 7002 native FabH with a Chaetoceros ketoacyl-ACP synthase III increased MCFA synthesis up to five fold. The level of increase is dependent on promoter strength and culturing conditions.

  2. AGILE DRAFTING OF OUTSOURCING CONTRACTS

    DEFF Research Database (Denmark)

    Schlichter, Bjarne Rerup; Storgaard, Kristian

    2015-01-01

    The concept of ‘agility’ has become quite popular in the development of IT-artefacts and has created interest in the more general project management literature. The process of drafting complex contracts for large IT projects (service as well as software) is often done under time pressure and in s......The concept of ‘agility’ has become quite popular in the development of IT-artefacts and has created interest in the more general project management literature. The process of drafting complex contracts for large IT projects (service as well as software) is often done under time pressure...... and in several parallel tracks using different competencies. By the use of an illustrative case-study, this paper explores how scrum can be applied to enhance the process of drafting outsourcing contracts. The analysis indicates that the use of an agile method, such as Scrum, can be beneficial in this context...

  3. Claims in civil engineering contracts

    CERN Document Server

    Speirs, N A

    1999-01-01

    This paper considers claims arising during civil engineering construction contracts. The meaning of the word 'claim' is considered and its possible implications for additional cost and time to completion. The conditions of the construction contract selected will influence the risk apportionment between contractor and client and the price offered by the contractor for the work. Competitive bidding constraints and profit margins in the construction industry, however, may also influence the price offered. This in turn can influence the likelihood of claims arising. The client from his point of view is concerned to complete the work within an agreed time and budget. The circumstances under which claims may arise are reviewed in relation to typical conditions of contract. These circumstances are then related to the CERN LHC civil works. Ways of avoiding claims, where this is possible, are considered. Finally, the means of evaluation of claims and their settlement are considered.

  4. Principles of European Contract Law

    DEFF Research Database (Denmark)

    Lando, Ole; Beale, Hugh

    of articles, with a detailed commentary explaining the purpose and operation of each article and its relation to the remainder. Each article also has extensive comparative notes surveying the national laws and other international provisions on the topic. "The Principles of European Contract Law Parts I &......This text provides a comprehensive guide to the principles of European contract law. They have been drawn up by an independent body of experts from each Member State of the EU, under a project supported by the European Commission and many other organizations. The principles are stated in the form......; II" cover the core rules of contract: formation, authority of agents, validity, interpretation, contents, performance, non-performance and remedies. The articles previously published in Part I (1995) are included in a revised and re-ordered form. Throughout Europe there is great interest...

  5. The Contracting Parties' Ability To Conclude The Employment Contract

    Directory of Open Access Journals (Sweden)

    Carmen Constantina NENU

    2014-08-01

    Full Text Available This study's main objective is to analyze certain effects produced by the changes of the Labor Code and by the entry into force of the current Romanian Civil Code. These effects refer to one of the fundamental conditions for the valid conclusion of the individual employment contract, that is, to the legal capacity of employers and employees. Thus, a complete analysis of legal regulations and of the correlations between different provisions on the legal capacity of parties to the individual employment contract is required to identify the existing noncompliance and to propose solutions. The research demonstrated that the current regulatory framework governing the legal capacity of the parties to an individual employment contract does not entirely correspond to the social reality. Therefore, only the employer benefits from a relatively comprehensive statutory regulation on the legal capacity to conclude an individual employment contract. The employee, however, does not benefit from the same attention from legislature. Considering the above, the study represents a significant scientific contribution, whose value lies in the proposed changes to modify legislature, so that the legal capacity of job holders would benefit from fair regulation, in accordance with the principle of legal protection of employee rights.

  6. Debt renegotiation with incomplete contract

    Directory of Open Access Journals (Sweden)

    Paulo de Melo Jorge Neto

    2005-09-01

    Full Text Available A debt contract usually does not include a provision about renegotiation. The right to seize the borrower’s asset and the rules of this process are usually stipulated in the contract. Such a promise not to renegotiate is not credible since renegotiation can mitigate the dead-weight loss of liquidating insolvent borrowers. Once the initial contract may not consider the renegotiation procedure and renegotiation may occur, this paper investigates why a complete contract is not offered. It shows that the lender does not need to stipulate the renegotiation procedure on the initial contract because he is indifferent about committing or not to the terms of a contract. This indicates that a complete contract gives the lender the same expected return as an incomplete contract, in which the renegotiation process is determined after the occurrence of default.Um contrato de débito geralmente não inclui uma cláusula sobre renegociação. O direito de liquidar os ativos do tomador e as regras do processo são habitualmente estipuladas no contrato. Tal promessa de não renegociar não é crível, já que a renegociação pode mitigar a perda bruta de se liquidar tomadores insolventes. Uma vez que o contrato inicial pode não considerar os procedimentos de renegociação, e esta pode, de fato, vir a ocorrer, este artigo investiga a razão de um contrato completo não ser ofertado. Mostra-se que o emprestador não precisa estipular os procedimentos de renegociação no contrato inicial porque ele é indiferente entre se comprometer ou não aos termos do contrato. Isto indica que um contrato completo dá ao emprestador o mesmo retorno esperado de um contrato incompleto, no qual os procedimentos de renegociação são determinados após a declaração de default.

  7. MANDATORY CLAUSES IN MEDIATION CONTRACTS

    Directory of Open Access Journals (Sweden)

    VERONICA STOICA

    2011-04-01

    Full Text Available The mediation contract – a contract by which conflicting parties agree, in conjunction with a mediator, upon conflict resolve in an amiable manner through the agency of mediation, under due efforts on the mediator’s part, in exchange for payment of a fee by the parties – must contain a set of mandatory clauses in compliance with legal provisions, Article 45 of Law no. 192/2006. In the absence of one of said clauses, sanction by absolute annulment is imposed.

  8. Forthcoming indefinite contract review procedure

    CERN Multimedia

    HR Department

    2011-01-01

    The vacancy notices for posts opened with a view to the award of an indefinite contract will be published as from the last week of September.  In the meantime, the list of posts to be opened is available at the following address: https://hr-recruit.web.cern.ch/hr-recruit/staff/Autumn_2011_listofslots.pdf Information sessions for candidates are being organised for 26 and 27 September 2011. For more information please consult:  https://hr-recruit.web.cern.ch/hr-recruit/staff/IndefiniteContracts.asp

  9. Paperless Contract Folder's (PCF) DoD 5015.2 certification

    OpenAIRE

    Flynn, Kimberly C.; Boorom, Eric W.; Grasso, Colleen E.

    2010-01-01

    Joint Applied Project The objective of this project is to conduct an analysis of the CECOM Contracting Center's Paperless Contracting Folder program in regards to maintaining its DoD 5015.2 certification. The desired outcomes will be the creation of a File Plan and User Guide to assist with DoD 5015.2 certification.

  10. 7 CFR 760.205 - Eligible producers, owners, and contract growers.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false Eligible producers, owners, and contract growers. 760... Livestock, Honeybees, and Farm-Raised Fish Program § 760.205 Eligible producers, owners, and contract... eligibility rules that may apply to be eligible as a: (1) Livestock owner for the payment with respect to the...

  11. 24 CFR 402.5 - Contract renewals under section 524(b) or (e) of MAHRA.

    Science.gov (United States)

    2010-04-01

    ... this part except § 402.7, upon expiration of a Section 8 contract entered into pursuant to a Portfolio... inappropriate, and the owner of the project executed a Portfolio Reengineering Demonstration Program Use... those provided under the contract that is expiring. This paragraph (d)(2) applies only to the extent...

  12. 48 CFR 2919.705-6 - Post-award responsibilities of the contracting officer.

    Science.gov (United States)

    2010-10-01

    ... Business Subcontracting Program 2919.705-6 Post-award responsibilities of the contracting officer. (a) Even... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Post-award responsibilities of the contracting officer. 2919.705-6 Section 2919.705-6 Federal Acquisition Regulations System...

  13. Navy Shipbuilding: Need to Document Rationale for the Use of Fixed-Price Incentive Contracts and Study Effectiveness of Added Incentives

    Science.gov (United States)

    2017-03-01

    purposes of this report we refer to the program as the ESD/ESB program. 4For the LCS contracts the Navy added a ship to each contract post -award... responsibility for all costs and resulting profit or loss. This contract type is suitable for situations where the government and shipbuilder have a...both of these situations, under a firm-fixed-price contract the shipbuilder assumes full responsibility for all costs and the

  14. Comparative evaluation of the effects of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and xylitol-containing chewing gum on salivary flow rate, pH and buffering capacity in children: Anin vivostudy.

    Science.gov (United States)

    Hegde, Rahul J; Thakkar, Janhavi B

    2017-01-01

    This study aimed to compare and evaluate the changes in the salivary flow rate, pH, and buffering capacity before and after chewing casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) and xylitol-containing chewing gums in children. Sixty children aged between 8 and 12 years were selected for the study. They were randomly divided into Group 1 (CPP-ACP chewing gum) and Group 2 (xylitol-containing chewing gum) comprising thirty children each. Unstimulated and stimulated saliva samples at 15 and 30 min interval were collected from all children. All the saliva samples were estimated for salivary flow rate, pH, and buffering capacity. Significant increase in salivary flow rate, pH, and buffering capacity from baseline to immediately after spitting the chewing gum was found in both the study groups. No significant difference was found between the two study groups with respect to salivary flow rate and pH. Intergroup comparison indicated a significant increase in salivary buffer capacity in Group 1 when compared to Group 2. Chewing gums containing CPP-ACP and xylitol can significantly increase the physiochemical properties of saliva. These physiochemical properties of saliva have a definite relation with caries activity in children.

  15. Comparative evaluation of the effects of casein phosphopeptide-amorphous calcium phosphate (CPP-ACP and xylitol-containing chewing gum on salivary flow rate, pH and buffering capacity in children: An in vivo study

    Directory of Open Access Journals (Sweden)

    Rahul J Hegde

    2017-01-01

    Full Text Available Aim: This study aimed to compare and evaluate the changes in the salivary flow rate, pH, and buffering capacity before and after chewing casein phosphopeptide-amorphous calcium phosphate (CPP-ACP and xylitol-containing chewing gums in children. Materials and Methods: Sixty children aged between 8 and 12 years were selected for the study. They were randomly divided into Group 1 (CPP-ACP chewing gum and Group 2 (xylitol-containing chewing gum comprising thirty children each. Unstimulated and stimulated saliva samples at 15 and 30 min interval were collected from all children. All the saliva samples were estimated for salivary flow rate, pH, and buffering capacity. Results: Significant increase in salivary flow rate, pH, and buffering capacity from baseline to immediately after spitting the chewing gum was found in both the study groups. No significant difference was found between the two study groups with respect to salivary flow rate and pH. Intergroup comparison indicated a significant increase in salivary buffer capacity in Group 1 when compared to Group 2. Conclusion: Chewing gums containing CPP-ACP and xylitol can significantly increase the physiochemical properties of saliva. These physiochemical properties of saliva have a definite relation with caries activity in children.

  16. EFEITO DE DIFERENTES PROTOCOLOS DE DESCONGELAÇÃO SOBRE O SÊMEN CANINO CRIOPRESERVADO EM DILUIDOR À BASE ÁGUA DE COCO EM PÓ (ACP-106®

    Directory of Open Access Journals (Sweden)

    Victor Leão Hitzschky Madeira

    2010-12-01

    Full Text Available It is known that temperature and thawing velocity can affect sperm quality during freeze-thawing procedures. Thus, the aim of this research was to compare different thawing protocols for canine semen extended in ACP-106® extender and cryopreserved. Ten ejaculates were collected from eight dogs and sperm rich fraction was evaluated regarding volume, concentration, motility, vigor, pH, morphology, acrosomal integrity and hyposmotic swelling test. Then, semen was extended in ACP-106® with 20% egg yolk and 6% glycerol, and frozen in 0.25 mL straws. After one week, one straw was thawed at 37°C/60s, another one at 55°C/5s and a third one at 75°C/8s, and the seminal characteristics were reevaluated. Similar results were observed for all the groups, except for sperm motility which was better preserved at 55°C/5s for up 30min than at 37°C/60s or 75°C/8s. From these results, it is concluded that canine semen extended in ACP -106® is better thawed at 55°C/5s.

  17. Specification Section 01065S ES&H for Service Contracts

    Energy Technology Data Exchange (ETDEWEB)

    Kirsch, Greg C. [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States)

    2014-07-01

    Section Includes: Requirements and guidelines in performance of work concerning protection of environment and property, and the safety and health of Contractors, Sandia National Laboratories (SNL) and Department of Energy (DOE) employees, visitors to SNL, and members of the public. This Section is applicable only to Service Contracts that do not involve construction or construction-like activities. Construction and construction-like activities are covered by Section 01065, Environment, Safety and Health (ES&H) for Construction Contracts. The entire ES&H program shall focus on safe-by-design intent, understanding the technical basis for the work, identifying and controlling energy sources, unacceptable consequences, risk assessments, and positive verification.

  18. Incentive Contracts and Cost Growth

    Science.gov (United States)

    1983-10-31

    Jack Livingston. Also see draft of DOI acd NASA Incentive Contracting Guide, Jan. 467.) Industry might not set up an infrastructure to implement...cmiuurcial ve tures is fusided through DOD business. I Can an Wicentive based on profit maximization function effectively in the above- environment? It is

  19. Digital content contracts for consumers

    NARCIS (Netherlands)

    Helberger, N.; Loos, M.B.M.; Guibault, L.; Mak, C.; Pessers, L.

    2013-01-01

    The application of consumer law to digital content contracts encounters a number of obstacles. Some of these are rather typical for digital content markets, e.g., the legal consequences of the classification of digital content as "goods" or "services" and, more importantly, the absence of general

  20. Crafting Contracts for International Projects.

    Science.gov (United States)

    Richey, John B.

    1993-01-01

    A discussion of the drafting of contracts for international sponsored research projects focuses on the terms of award that relate either to sensitive topics for international sponsors or to significant legal or financial risk to an institution. Issues specific to newly industrializing and developing countries are highlighted. (MSE)

  1. On CNC commuting contractive tuples

    Indian Academy of Sciences (India)

    automorphisms; functional model; coincidence. 1. Introduction. The characteristic function for a single contraction on a Hilbert space was defined by. Sz-Nagy and Foias in [23]. Since then it has drawn a lot of attention and several interesting results are known. A tupleT = (T1,...,Tn)of bounded operators on a Hilbert spaceHis ...

  2. Forestry contracting in South Africa

    CSIR Research Space (South Africa)

    Khosa, M

    2000-01-01

    Full Text Available of their workers directly to a contractor system. For example, forest contractors are now hired to carry out planting, tending and silvicultural operations. Sappi Forests, Mondi Forests and Safcol are all contracting certain work out and are currently assisting...

  3. Unbalanced Bidding in Government Contracts

    Science.gov (United States)

    1989-02-19

    the options will be excercised ) not to evaluate the options at the time of award? The FAR gives no guidance on how to deal with unbalanced option prices...surgically remove the cancer -us part of the contract relating to the enhanced bid price through partial termination for convenience? Until a few years

  4. Performance Contracting: A Balanced View.

    Science.gov (United States)

    Anderson, Richard R.

    This paper presents the sum of both individual research and the five papers specially prepared for the Upper Midwestern Region Interstate Project Constracting Conference (Minneapolis, Minnesota, May 9-10, 1972.) In particular, the various sections that comprise the publication speak to those aspects of performance contracting suggested for the…

  5. Improving Army Operational Contract Support

    Science.gov (United States)

    2013-04-01

    8. PERFORMING ORGANIZATION REPORT NUMBER 9. SPONSORING/MONITORING AGENCY NAME(S) AND ADDRESS(ES) Dr. Richard M. Meinhart U.S. Army War...Austin Project Adviser Dr. Richard M. Meinhart U.S. Army War College Faculty Mentor This manuscript is submitted in partial...Improving Army Operational Contract Support by Colonel Daryl P. Harger United States Army United

  6. Jazzing up the Psychological Contract

    Science.gov (United States)

    Hartley, Nell Tabor

    2010-01-01

    Helping students and practitioners to understand and utilize the Psychological Contract is often a difficult task. Unlike fault-finding research, this paper presents the PC as a positive, vibrant and valuable tool. In an effort to make the concept less elusive, the paper draws upon the metaphor of jazz. The metaphor is an accepted tool of…

  7. SSC Test Operations Contract Overview

    Science.gov (United States)

    Kleim, Kerry D.

    2010-01-01

    This slide presentation reviews the Test Operations Contract at the Stennis Space Center (SSC). There are views of the test stands layouts, and closer views of the test stands. There are descriptions of the test stand capabilities, some of the other test complexes, the Cryogenic propellant storage facility, the High Pressure Industrial Water (HPIW) facility, and Fluid Component Processing Facility (FCPF).

  8. Construction contract revenue recording comparison

    Directory of Open Access Journals (Sweden)

    Hana Bohušová

    2008-01-01

    Full Text Available Publicly traded companies prepare their consolidated accounts in conformity with the international accounting standards (IAS/IFRS in accordance with the Regulation No. 1606/2002. This is obliged for all publicly traded joint-stock companies in the Czech Republic. Other companies prepare financial statements in accordance with national accounting standards. There are Accounting Act No. 563/1991 of Coll. and Regulation No. 500/2002 of Coll., Czech Accounting Standards in the Czech Republic. Both systems are based on different principles so there are many differences. The Czech Accounting System (CAS is based on the rules while IAS/IFRS are based on principles (Kovanicová, 2005. These differences are mainly caused by the different philosophy. CAS prefers the fiscal policy to the economic substance while IAS/IFRS prefere the economic substance. One of the most significant dif­fe­ren­ces is in the field of revenue recording. There are two standards concerning the revenues recording (IAS 18 − Revenue, IAS 11 – Construction Contracts in IAS/IFRS. CAS 019 – Expenses and Revenue are dealing with the revenue recording in the Czech Republic. The paper is aimed at the comparison of the methodical approaches for revenue recording used by IAS/IFRS and by CAS. The most important differences are caused by the different approach to the long term contracts (construction contracts, software development contracts revenues recording.

  9. Analysis of Commercial Contract Training.

    Science.gov (United States)

    Copeland, D. Robert; And Others

    The report describes the Phase I findings of a two-phase study to determine the applications of commercial contract training to the Navy Training System. The objective of the study is to determine if commercial sources would be cost and training effective alternatives for current and peak Navy skill training requirements. The study was conducted…

  10. Supply contract and portfolio insurance

    Science.gov (United States)

    Runsheng Yin; Bob Izlar

    2001-01-01

    The long-term growth of institutional timberland investments depends on the ability of timberland investment management organizations (TIMO) to deal effectively with securitization, leveraging, arbitraging, supply contracting, portfolio insurance, tax efficiency enhancement, and other issues. Financial engineering holds great promise for many of these issues. This...

  11. [Patient safety in management contracts].

    Science.gov (United States)

    Campillo-Artero, C

    2012-01-01

    Patient safety is becoming commonplace in management contracts. Since our experience in patient safety still falls short of other clinical areas, it is advisable to review some of its characteristics in order to improve its inclusion in these contracts. In this paper opinions and recommendations concerning the design and review of contractual clauses on safety are given, as well as reflections drawn from methodological papers and informal opinions of clinicians, who are most familiar with the nuances of safe and unsafe practices. After reviewing some features of these contracts, criteria for prioritizing and including safety objectives and activities in them, and key points for their evaluation are described. The need to replace isolated activities by systemic and multifaceted ones is emphasized. Errors, limitations and improvement opportunities observed when contracts are linked to indicators, information and adverse event reporting systems are analysed. Finally, the influence of the rules of the game, and clinicians behaviour are emphasised. Copyright © 2011 SECA. Published by Elsevier Espana. All rights reserved.

  12. Clinical assessment of uterine contractions.

    Science.gov (United States)

    Cohen, Wayne R

    2017-11-01

    The assessment of uterine contractions is important in clinical decision-making, but the precise role for appraising contractions remains controversial. Four clinical approaches to assessing contractions are available: manual palpation; intrauterine pressure determination; external tocodynamometry; and electrohysterography. Palpation is inexpensive and harmless but requires the constant bedside presence of a trained observer. Intrauterine pressure measurement is considered the most sensitive and specific technique, and has become the standard by which other methods are judged; however, its quantitative measurements are not always precise or reproducible. Moreover, the availability of intrauterine pressure measurements does not seem to improve maternal or neonatal outcomes in most situations. External tocodynamometry is the most widely used technique. It is easy to apply and provides reasonably accurate information about the frequency and duration of contractions, but not their amplitude. It can require frequent adjustment during labor and might not work well in patients who are obese. Electrohysterography is a recently available noninvasive technology that detects uterine electrical activity using electrodes placed on the mother's abdominal wall. This approach is at least as reliable and accurate as tocodynamometry. © 2017 International Federation of Gynecology and Obstetrics.

  13. Towards Certified Management of Financial Contracts

    DEFF Research Database (Denmark)

    Bahr, Patrick; Berthold, Jost; Elsman, Martin

    2014-01-01

    . The seminal work by Peyton-Jones and Eber on financial contracts shows how an algebraic approach to contract specification can be used for valuation of contracts (when combined with a model of the underlying observables) and for managing how contracts evolve under so-called fixings and decision......-taking, with the contracts eventually evaporating into the empty contract, for which no party have further obligations. The ideas have emerged into Eber's company LexiFi, which has become a leading software provider for a range of financial institutions, with all contract management operations centralised around a domain......Banks and financial institutions nowadays often use domain-specific languages (DSLs) for describing complex financial contracts, in particular, for specifying how asset transfers for a specific contract depend on underlying observables, such as interest rates, currency rates, and stock prices...

  14. Termination of Commercial Contracts by giving Notice

    DEFF Research Database (Denmark)

    Edlund, Hans Henrik

    2008-01-01

    or not the contract can be terminated by giving notice. The international UNIDROIT principles and the Lando Commission have included a rule allowing the parties to a contract which is for an indefinite period to give notice, but it can be very difficult to distinguish between indefinite and definite periods......Some long-term contracts are brought to an end if one of the parties gives notice. Usually, such a step is not considered a breach of contract. It causes the contract to end in accordance with the contract. When no express rules cover the situation, it is often not entirely clear whether....... Furthermore, it is open to question whether the continuation of an expired contract is to be considered as a contract for an indefinite period, and whether contracts for definite periods are irrevocable. Even though these questions are not regulated, it is not recommended that new and more detailed principles...

  15. 41 CFR 101-26.508-1 - Requisitioning data processing tape available through Federal Supply Schedule contracts.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Requisitioning data processing tape available through Federal Supply Schedule contracts. 101-26.508-1 Section 101-26.508-1 Public... REGULATIONS SUPPLY AND PROCUREMENT 26-PROCUREMENT SOURCES AND PROGRAM 26.5-GSA Procurement Programs § 101-26...

  16. 41 CFR 101-26.509-1 - Requisitioning tabulating machine cards available from Federal Supply Schedule contracts.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Requisitioning tabulating machine cards available from Federal Supply Schedule contracts. 101-26.509-1 Section 101-26.509-1 Public... REGULATIONS SUPPLY AND PROCUREMENT 26-PROCUREMENT SOURCES AND PROGRAM 26.5-GSA Procurement Programs § 101-26...

  17. Report: Improved Contract Administration Needed for the Customer Technology Solutions Contract

    Science.gov (United States)

    Report #13-P-0398, September 16, 2013. Based on our review of the WCF contract EPW08034, which ended September 2012, the EPA needs to improve its contract administration to assist in managing other similar type contracts.

  18. Financial Management: Reopening of Contracts in the Mechanization of Contract Administration Services System

    National Research Council Canada - National Science Library

    Granetto, Paul

    2003-01-01

    .... In anticipation of transitioning to the new contract payment system, the Defense Finance and Accounting Service and the Defense Contract Management Agency were attempting to close out as many contracts as possible...

  19. 42 CFR 457.955 - Conditions necessary to contract as a managed care entity (MCE).

    Science.gov (United States)

    2010-10-01

    ...) ALLOTMENTS AND GRANTS TO STATES Program Integrity § 457.955 Conditions necessary to contract as a managed...; (2) Prohibit MCEs from conducting any unsolicited personal contact with a potential enrollee by an...

  20. Some Contracting Controls at Mission and Installation Contracting Command, Fort Polk, Louisiana, Need Improvement

    Science.gov (United States)

    2015-02-12

    Ability One contract. Early in our preliminary field work, we decided to review contract DACA87-94-C-0008, an energy savings performance contract to...install and maintain geothermal heat pumps on Fort Polk in a separate audit. To review MICC Fort Polk contract controls, we obtained and reviewed the...following documents except as noted for all three contracts: • basic contracts and subsequent modifications,11 • applicable purchase requests

  1. Three-dimensional (3D) structure prediction of the American and African oil-palms β-ketoacyl-[ACP] synthase-II protein by comparative modelling.

    Science.gov (United States)

    Wang, Edina; Chinni, Suresh; Bhore, Subhash Janardhan

    2014-01-01

    The fatty-acid profile of the vegetable oils determines its properties and nutritional value. Palm-oil obtained from the African oil-palm [Elaeis guineensis Jacq. (Tenera)] contains 44% palmitic acid (C16:0), but, palm-oil obtained from the American oilpalm [Elaeis oleifera] contains only 25% C16:0. In part, the b-ketoacyl-[ACP] synthase II (KASII) [EC: 2.3.1.179] protein is responsible for the high level of C16:0 in palm-oil derived from the African oil-palm. To understand more about E. guineensis KASII (EgKASII) and E. oleifera KASII (EoKASII) proteins, it is essential to know its structures. Hence, this study was undertaken. The objective of this study was to predict three-dimensional (3D) structure of EgKASII and EoKASII proteins using molecular modelling tools. The amino-acid sequences for KASII proteins were retrieved from the protein database of National Center for Biotechnology Information (NCBI), USA. The 3D structures were predicted for both proteins using homology modelling and ab-initio technique approach of protein structure prediction. The molecular dynamics (MD) simulation was performed to refine the predicted structures. The predicted structure models were evaluated and root mean square deviation (RMSD) and root mean square fluctuation (RMSF) values were calculated. The homology modelling showed that EgKASII and EoKASII proteins are 78% and 74% similar with Streptococcus pneumonia KASII and Brucella melitensis KASII, respectively. The EgKASII and EoKASII structures predicted by using ab-initio technique approach shows 6% and 9% deviation to its structures predicted by homology modelling, respectively. The structure refinement and validation confirmed that the predicted structures are accurate. The 3D structures for EgKASII and EoKASII proteins were predicted. However, further research is essential to understand the interaction of EgKASII and EoKASII proteins with its substrates.

  2. Functional, thermodynamics, structural and biological studies of in silico-identified inhibitors of Mycobacterium tuberculosis enoyl-ACP(CoA) reductase enzyme

    Science.gov (United States)

    Martinelli, Leonardo K. B.; Rotta, Mariane; Villela, Anne D.; Rodrigues-Junior, Valnês S.; Abbadi, Bruno L.; Trindade, Rogério V.; Petersen, Guilherme O.; Danesi, Giuliano M.; Nery, Laura R.; Pauli, Ivani; Campos, Maria M.; Bonan, Carla D.; de Souza, Osmar Norberto; Basso, Luiz A.; Santos, Diogenes S.

    2017-04-01

    Novel chemotherapeutics agents are needed to kill Mycobacterium tuberculosis, the main causative agent of tuberculosis (TB). The M. tuberculosis 2-trans-enoyl-ACP(CoA) reductase enzyme (MtInhA) is the druggable bona fide target of isoniazid. New chemotypes were previously identified by two in silico approaches as potential ligands to MtInhA. The inhibition mode was determined by steady-state kinetics for seven compounds that inhibited MtInhA activity. Dissociation constant values at different temperatures were determined by protein fluorescence spectroscopy. van’t Hoff analyses of ligand binding to MtInhA:NADH provided the thermodynamic signatures of non-covalent interactions (ΔH°, ΔS°, ΔG°). Phenotypic screening showed that five compounds inhibited in vitro growth of M. tuberculosis H37Rv strain. Labio_16 and Labio_17 compounds also inhibited the in vitro growth of PE-003 multidrug-resistant strain. Cytotoxic effects on Hacat, Vero and RAW 264.7 cell lines were assessed for the latter two compounds. The Labio_16 was bacteriostatic and Labio_17 bactericidal in an M. tuberculosis-infected macrophage model. In Zebrafish model, Labio_16 showed no cardiotoxicity whereas Labio_17 showed dose-dependent cardiotoxicity. Accordingly, a model was built for the MtInhA:NADH:Labio_16 ternary complex. The results show that the Labio_16 compound is a direct inhibitor of MtInhA, and it may represent a hit for the development of chemotherapeutic agents to treat TB.

  3. Assessment of Army Contracting Command’s Contract Management Processes

    Science.gov (United States)

    2010-06-16

    D. M., Clouse, A., & Turner, R. (2001). CMMI , distilled. Boston: Addison- Wesley. Army Aviation and Missile Command (AMCOM)(2009). AMCOM Fact Sheet...organizational culture at naval air systems command (Master’s Thesis ). Monterey, CA: Naval Postgraduate School. Kraljic, P. (1983, September...J. (2008, January). Analysis of the contracting processes and ethical culture at Ogden Air Logistics Center, Hill AFB, UT (Master’s Thesis

  4. Contract Design, Supply Chain Complexity, and Accountability in Federal Contracts

    Science.gov (United States)

    2016-04-30

    Fluctuations in market demand can be expected, but there can be more volatility for certain final goods, and this volatility will affect the entire...overriding goal may be ensuring that the supply chain is buffered from external volatility in order to protect the organizations that are involved in the...Incentive contracts, which allow suppliers to earn an additional fee based on meeting specified performance objectives, are characterized as a risk

  5. Demographics of the Contracting Workforce within the Army Contracting Command

    Science.gov (United States)

    2009-09-25

    Empresas in Madrid. Dr. Reed retired from Active Military Service in 2008 after 21 years in the Air Force. Dr. Reed held various assignments in...and Local Government, business, and marketing applications, it focuses on human resource planning and the difficulties of expanding and contracting...testimony indicated the use of these tools could have a significant effect on reducing the workforce, allowing for a change in the skills and mix of

  6. Analysis of Naval Facilities Engineering Command's (NAVFAC) Contracting Processes Using the Contract Management Maturity Model (CMMM)

    National Research Council Canada - National Science Library

    Ludwig, Walter S; Moore, Alexander M

    2006-01-01

    .... The purpose of this study is to analyze NAVFAC's contracting processes, establish a baseline for contract management maturity and ethical context, and recommend target areas for improvement efforts...

  7. Asiago Supernova classification program: Blowing out the first two hundred candles

    Science.gov (United States)

    Tomasella , L.; Benetti, S.; Cappellaro, E.; Pastorello, A.; Turatto, M.; Barbon, R.; Elias-Rosa, N.; Harutyunyan, A.; Ochner, P.; Tartaglia, L.; Valenti, S.

    2014-10-01

    We present the compilation of the first 221 supernovae classified during the Asiago Classification Program (ACP). The details of transients classification and the preliminarily reduced spectra, in fits format, are immediately posted on the Padova-Asiago SN group web site. The achieved performances for the first 2 years of the ACP are analysed, showing that half of all our classifications were made within 5 days from transient detection. The distribution of the supernova types of this sample resembles the distribution of the general list of all the supernovae listed in the Asiago SN catalog (ASNC, Barbon et al. 1999). Finally, we use our subsample of 78 core-collapse supernovae, for which we retrieve the host-galaxy morphology and r-band absolute magnitudes, to study the observed subtype distribution in dwarf compared to giant galaxies. This ongoing program will give its contribution to the classification of the large number of transients that will be soon delivered by the Gaia mission.

  8. Russian Contract Law for Foreigners

    Directory of Open Access Journals (Sweden)

    Andrey Shirvindt

    2015-01-01

    Full Text Available The book by Maria Efremova, Svetlana Yakovleva and Jane Henderson aims to serve as a short introduction to Russian contract law for a foreign lawyer. Assuming that the target readership are mainly English lawyers the book’s second aim, expressly stated by the authors (pp. i, 1, is to make lawyers from common law countries familiar with codified law, with Russian law being just an example. The book covers most of the general law of obligations as well as some questions of formation and invalidity of contracts that belong to the general part of the Civil Сode, with this preceded by a brief introduction into the Russian law dealing with its history, federal structure and state agencies of Russia, its court system, sources of law and legal profession.

  9. New transport and handling contract

    CERN Multimedia

    SC Department

    2008-01-01

    A new transport and handling contract entered into force on 1.10.2008. As with the previous contract, the user interface is the internal transport/handling request form on EDH: https://edh.cern.ch/Document/TransportRequest/ To ensure that you receive the best possible service, we invite you to complete the various fields as accurately as possible and to include a mobile telephone number on which we can reach you. You can follow the progress of your request (schedule, completion) in the EDH request routing information. We remind you that the following deadlines apply: 48 hours for the transport of heavy goods (up to 8 tonnes) or simple handling operations 5 working days for crane operations, transport of extra-heavy goods, complex handling operations and combined transport and handling operations in the tunnel. For all enquiries, the number to contact remains unchanged: 72202. Heavy Handling Section TS-HE-HH 72672 - 160319

  10. 48 CFR 19.808 - Contract negotiation.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Contract negotiation. 19.808 Section 19.808 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION SOCIOECONOMIC....808 Contract negotiation. ...

  11. Renewable Energy Contract Development Best Practices

    Science.gov (United States)

    This page provides information on how available resources can help organizations effectively navigate the solar contract development process with the goal of RFP and contract transparency, completeness, and accountability of all involved parties.

  12. Dynamic contracting mechanism for pavement maintenance management

    NARCIS (Netherlands)

    Demirel, H.C.; De Ridder, H.A.J.

    2013-01-01

    Technological advances, financial possibilities and changes of demands have increasingly affected the pavement maintenance environment for outsourcing in recent years. This induces complexity in the contracting methods of pavement maintenance activities. Despite the fact that current contracting

  13. 78 FR 54687 - International Mail Contract

    Science.gov (United States)

    2013-09-05

    ... International Mail Contract AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: The Commission is noticing a recent Postal Service filing seeking to include a new International Business Reply Service (IBRS... a Functionally Equivalent International Business Reply Service Competitive Contract 3 Negotiated...

  14. The Public Sector and Obligation to Contract

    DEFF Research Database (Denmark)

    Olesen, Karsten Naundrup; Indén, Tobias

    2016-01-01

    The paper concerns the situation where public sector bodies are forced to enter into contracts. These obligations to contract are analysed from two angles. First, the paper offers an analysis of the reasons for imposing such obligations to contract under Swedish and Danish law. Secondly the paper...... discusses some consequences of the public entities’ obligations to contract, more specific consequences for the use of rules that usually regulate contracts and the fact that obligations to contract imposed on public entities establish a new market and at the same time the obligations deprive the entities...... of the freedom to contract which is a fundamental to market behaviour. Finally attention is drawn to the fact that obligations to contract are also imposed on private entities. The paper takes Swedish and Danish regulations as a point of departure and provides an insight into regulations from these two countries...

  15. Senior Administrators Should Have Administrative Contracts.

    Science.gov (United States)

    Posner, Gary J.

    1987-01-01

    Recognizing that termination is viewed by the employee as the equivalent to capital punishment of a career, an administrative contract can reduce the emotional and financial entanglements that often result. Administrative contracts are described. (MLW)

  16. 48 CFR 239.7103 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... OF DEFENSE SPECIAL CATEGORIES OF CONTRACTING ACQUISITION OF INFORMATION TECHNOLOGY Security and... performance of information assurance functions as described in DoD 8570.01-M. ... Against Compromising Emanations, in solicitations and contracts involving information technology that...

  17. Inflation Persistence and Relative Contracting

    OpenAIRE

    John C. Driscoll; Steinar Holden

    2003-01-01

    Macroeconomists have for some time been aware that the New Keynesian Phillips curve, though highly popular in the literature, cannot explain the persistence observed in actual inflation. We argue that one of the more prominent alternative formulations, the Fuhrer and Moore (1995) relative contracting model, is highly problematic. Fuhrer and Moore's 1995 formulation generates inflation persistence, but this is a consequence of their assuming that workers care about the past real wages of other...

  18. Forthcoming indefinite contract review procedure

    CERN Multimedia

    2012-01-01

    The vacancy notices for posts opened with a view to the award of an indefinite contract will be published as from the first week of July 2012.   In the meantime, the list of posts to be opened will soon be available at the following address: https://hr-recruit.web.cern.ch/hr-recruit/staff/ListOfPosts-Autumn2012.pdf For more information please consult this page.

  19. Custom, contract, and kidney exchange.

    Science.gov (United States)

    Healy, Kieran; Krawiec, Kimberly D

    2012-01-01

    In this Essay, we examine a case in which the organizational and logistical demands of a novel form of organ exchange (the nonsimultaneous, extended, altruistic donor (NEAD) chain) do not map cleanly onto standard cultural schemas for either market or gift exchange, resulting in sociological ambiguity and legal uncertainty. In some ways, a NEAD chain resembles a form of generalized exchange, an ancient and widespread instance of the norm of reciprocity that can be thought of simply as the obligation to “pay it forward” rather than the obligation to reciprocate directly with the original giver. At the same time, a NEAD chain resembles a string of promises and commitments to deliver something in exchange for some valuable consideration--that is, a series of contracts. Neither of these salient "social imaginaries" of exchange--gift giving or formal contract--perfectly meets the practical demands of the NEAD system. As a result, neither contract nor generalized exchange drives the practice of NEAD chains. Rather, the majority of actual exchanges still resemble a simpler form of exchange: direct, simultaneous exchange between parties with no time delay or opportunity to back out. If NEAD chains are to reach their full promise for large-scale, nonsimultaneous organ transfer, legal uncertainties and sociological ambiguities must be finessed, both in the practices of the coordinating agencies and in the minds of NEAD-chain participants. This might happen either through the further elaboration of gift-like language and practices, or through a creative use of the cultural form and motivational vocabulary, but not necessarily the legal and institutional machinery, of contract.

  20. Abordagem racional no planejamento de novos tuberculostáticos: inibidores da InhA, enoil-ACP redutase do M. tuberculosis Rational approach in the new antituberculosis agent design: inhibitors of InhA, the enoyl-ACP reductase from Mycobacterium tuberculosis

    Directory of Open Access Journals (Sweden)

    Carolina Horta Andrade

    2008-06-01

    Full Text Available Associada à disseminação da infecção causada pelo HIV, a tuberculose (TB é considerada, atualmente, problema mundial de saúde pública devido às proporções que vem assumindo. A resistência micobacteriana aos fármacos utilizados na terapêutica é a principal causa da reincidência da TB. Diante deste quadro alarmante, o desenvolvimento de novos e seletivos fármacos anti-TB se faz urgente e necessário. A biossíntese de ácidos graxos é um processo bioquímico realizado por procariotos e eucariotos, o qual fornece precursores essenciais à montagem de componentes celulares importantes, tais como fosfolipídeos, lipoproteínas, lipopolissacarídeos, ácidos micólicos e envelope celular. As diferenças bioquímicas e funcionais entre o mecanismo biossintético de ácidos graxos em bactérias e mamíferos tornam-no alvo relevante ao planejamento de novos antibacterianos, mais seletivos e menos tóxicos. As enoil-ACP redutases são enzimas cruciais à etapa de alongamento de ácidos graxos, considerados produtos intermediários na biossíntese de ácidos micólicos - os principais componentes da parede celular micobacteriana. Portanto, tais enzimas são tidas como alvos moleculares no planejamento racional de novos tuberculostáticos. Avanços recentes no processo de descoberta de novos agentes anti-TB, particularmente os inibidores da enoil-ACP redutase, serão discutidos nesta revisão.In conjunction with the spread of HIV infection, tuberculosis (TB has been among the worldwide health threats. Mycobacteria resistance to the drugs currently used in the therapeutics is the main cause of TB resurgence. In view of this severe situation, the new and selective anti-TB design is of utmost importance. Fatty acid biosynthesis is a prokariontes and eucariontes biochemical process that supplies essential precursors for the assembly of important cellular components, such as phospholipids, lipoproteins, lipopolysaccharides, mycolic acids and

  1. ALMOST IDEAL AREA YIELD CROP INSURANCE CONTRACTS

    OpenAIRE

    Smith, Vincent H.; Chouinard, Hayley H.; Baquet, Alan E.

    1994-01-01

    Using yield data for a sample of 123 dryland wheat producers in Montana, the effects of three area yield contracts, including the contract currently offered by the United States Federal Crop Insurance Corporation and two individual yield contracts on individual farm yield variability, are examined. The results indicate that while the Federal Crop Insurance Corporation area yield contract provides all farmers in the sample with some protection against yield variability, a simpler, actuarially ...

  2. Contract closeout pathologies and recovery strategies

    OpenAIRE

    Busansky, Michael D.

    2003-01-01

    Approved for public release; distribution is unlimited. The primary purpose of this thesis is to classify contract closeout pathologies, identify the root causes of these pathologies, and provide a series of strategies to regain control of the contract closeout process all within the context of the Organizational Systems Framework Model. Critical pathologies identified include process friction, inadequate information technology, contract complexity, personnel skill level, contract financia...

  3. Production Assistance for Cellular Therapies (PACT): four-year experience from the United States National Heart, Lung, and Blood Institute (NHLBI) contract research program in cell and tissue therapies.

    Science.gov (United States)

    Reed, William; Noga, Stephen J; Gee, Adrian P; Rooney, Cliona M; Wagner, John E; McCullough, Jeffrey; McKenna, David H; Whiteside, Theresa L; Donnenberg, Albert D; Baker, Acacia K; Lindblad, Robert W; Wagner, Elizabeth L; Mondoro, Traci Heath

    2009-04-01

    In 2002, the US National Heart, Lung, and Blood Institute (NHLBI) conducted a workshop to determine needs of the cell therapy community. A consensus emerged that improved access to cGMP facilities, regulatory assistance, and training would foster the advancement of cellular therapy. A 2003 NHLBI request for proposals resulted in four contracts being awarded to three cell-manufacturing facilities (Baylor College of Medicine, University of Minnesota, and University of Pittsburgh) and one administrative center (The EMMES Corporation). As a result, Production Assistance for Cellular Therapies (PACT) was formed. As of October 1, 2008, PACT has received 65 preliminary applications of which 45 have been approved for product manufacture. A variety of cell therapies are represented including T-regulatory cells, natural killer cells, adipose-derived stem cells, cardiac progenitor cells for cardiac disease, hematopoietic progenitor cells (HPCs) for central nervous system applications, cytotoxic T lymphocytes, and dendritic cells. A total of 169 products have been administered under 12 applications and 2 reagents were manufactured and delivered. Fourteen peer-reviewed publications and 15 abstracts have resulted from the PACT project to date. A cell therapy textbook is nearly complete. PACT technical projects have addressed assay development, rapid endotoxin testing, shipping of cell products, and CD34+ HPC isolation from low-volume marrow. Educational Web seminars and on-site training through workshops have been conducted. PACT is an active and successful cell therapy manufacturing resource in the United States, addressing research and training while forging relationships among academia, industry, and participating institutions.

  4. 48 CFR 4.1303 - Contract clause.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Contract clause. 4.1303 Section 4.1303 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL ADMINISTRATIVE MATTERS Personal Identity Verification 4.1303 Contract clause. The contracting officer shall...

  5. 48 CFR 46.710 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... Section 46.710 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT QUALITY ASSURANCE Warranties 46.710 Contract clauses. The clauses and alternates prescribed in this section may be used in solicitations and contracts in which inclusion of a warranty is appropriate (see 46...

  6. 48 CFR 1346.710 - Contract clauses.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Contract clauses. 1346.710 Section 1346.710 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE CONTRACT MANAGEMENT QUALITY ASSURANCE Warranties 1346.710 Contract clauses. The warranty clauses and alternates under FAR Subpart 46.710...

  7. 14 CFR 145.217 - Contract maintenance.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Contract maintenance. 145.217 Section 145...) SCHOOLS AND OTHER CERTIFICATED AGENCIES REPAIR STATIONS Operating Rules § 145.217 Contract maintenance. (a) A certificated repair station may contract a maintenance function pertaining to an article to an...

  8. Advantages of a leveled commitment contracting protocol

    Energy Technology Data Exchange (ETDEWEB)

    Sandholm, T.W.; Lesser, V.R. [Univ. of Massachusetts, Amherst, MA (United States)

    1996-12-31

    In automated negotiation systems consisting of self-interested agents, contracts have traditionally been binding. Such contracts do not allow agents to efficiently accommodate future events. Game theory has proposed contingency contracts to solve this problem. Among computational agents, contingency contracts are often impractical due to large numbers of interdependent and unanticipated future events to be conditioned on, and because some events are not mutually observable. This paper proposes a leveled commitment contracting protocol that allows self-interested agents to efficiently accommodate future events by having the possibility of unilaterally decommitting from a contract based on local reasoning. A decommitment penalty is assigned to both agents in a contract: to be freed from the contract, an agent only pays this penalty to the other party. It is shown through formal analysis of several contracting settings that this leveled commitment feature in a contracting protocol increases Pareto efficiency of deals and can make contracts individually rational when no full commitment contract can. This advantage holds even if the agents decommit manipulatively.

  9. 24 CFR 886.110 - Contract rents.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Contract rents. 886.110 Section 886... for Projects With HUD-Insured and HUD-Held Mortgages § 886.110 Contract rents. (a) The sum of the Contract Rents plus an Allowance for Utilities and Other Services shall not exceed the published Section 8...

  10. Periodic review in natural resource contracts | Mandelbaum ...

    African Journals Online (AJOL)

    Periodic contract review mechanisms, which are provisions in contracts that formally require parties to meet at particular intervals to review the terms of the contract, are mechanisms that may facilitate the process of negotiating contractual changes to accommodate changing circumstances over the term of extractive ...

  11. 40 CFR 262.85 - Contracts.

    Science.gov (United States)

    2010-07-01

    ... control procedures are prohibited unless they occur under the terms of a valid written contract, chain of... person who will have physical custody of the wastes; (3) Each person who will have legal control of the... recovery facilities must submit to EPA copies of contracts, chain of contracts, or equivalent arrangements...

  12. 77 FR 5280 - Service Contracts Inventory

    Science.gov (United States)

    2012-02-02

    ... COMMISSION Service Contracts Inventory AGENCY: Nuclear Regulatory Commission. ACTION: Notice of availability. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC) is providing for public information its Inventory of Contracts for Services for Fiscal Year (FY) 2011. The inventory includes service contract actions over $25...

  13. 78 FR 10642 - Service Contracts Inventory

    Science.gov (United States)

    2013-02-14

    ... COMMISSION Service Contracts Inventory AGENCY: Nuclear Regulatory Commission. ACTION: Notice of availability. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC) is providing for public information its Inventory of Contracts for Services for Fiscal Year (FY) 2012. The inventory includes service contract actions over $25...

  14. 75 FR 82095 - Service Contracts Inventory

    Science.gov (United States)

    2010-12-29

    ... Doc No: 2010-32828] NUCLEAR REGULATORY COMMISSION [NRC-2010-0394] Service Contracts Inventory AGENCY... Regulatory Commission (NRC) is providing for public information its Inventory of Contracts for Services for Fiscal Year (FY) 2010. The inventory includes service contract actions over $25,000 that were awarded in...

  15. Incentive contracts with unobservable competence levels

    DEFF Research Database (Denmark)

    Davis, Jerome; Keiding, Hans

    2008-01-01

    about the competence of the agent to fulfill the obligations of the contract. The agent offers a choice of contracts to the principal, thereby signalling agent competence to the principal, and there is no alternative reputation mechanism to the contract for the principal's bargaining strategy. It turns...

  16. 78 FR 48728 - International Mail Contract

    Science.gov (United States)

    2013-08-09

    ... International Mail Contract AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: The Commission is... obligation to provide its contracting partner, on a periodic basis, with a list of countries to which... an Additional Global Plus 1C Contract, January 11, 2013. IV. Ordering Paragraphs It is ordered: 1...

  17. 77 FR 26583 - International Mail Contract

    Science.gov (United States)

    2012-05-04

    ... International Mail Contract AGENCY: Postal Regulatory Commission. ACTION: Notice. ] SUMMARY: The Commission is... Package contract. This document invites public comments on the request and addresses several related... additional Global Reseller Expedited Package (GREP) contract.\\1\\ The Postal Service states that the instant...

  18. 77 FR 70849 - International Mail Contract

    Science.gov (United States)

    2012-11-27

    ... International Mail Contract AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: The Commission is... contract with China Post. This notice informs the public of the filing, invites public comment, and takes... Functionally Equivalent Agreement, November 15, 2012 (Notice). Contract history and scope. The Agreement is a...

  19. 77 FR 10577 - International Mail Contract

    Science.gov (United States)

    2012-02-22

    ... International Mail Contract AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: The Commission is... it has entered into an additional International Business Reply Service (IBRS) contract.\\1\\ The Postal... International Business Reply Service Competitive Contract 3 Negotiated Service Agreement, February 13, 2012...

  20. 77 FR 70850 - International Mail Contract

    Science.gov (United States)

    2012-11-27

    ... International Mail Contract AGENCY: Postal Regulatory Commission. ACTION: Notice. SUMMARY: The Commission is... contract with the postal operator of the Netherlands. This notice informs the public of the filing, invites... expiration of rates in the existing TNT Agreement. Id. at 3. Contract history. The Agreement is a successor...