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Sample records for program aap aap

  1. Tectonics wins AAP Award

    Science.gov (United States)

    AGU's newest journal, Tectonics, won the 1983 award for excellence in journal design and production given by the Association of American Publishers, Inc. (AAP), in the eighth annual professional and scholarly publishing awards competition. Edited by John F. Dewey, the bimonthly journal is a joint publication of AGU and the European Geophysical Society. Paul E. Tapponnier is the European editor and B.C. Burchfiel is the North American editor. The journal is now in its third year of publication.

  2. Transport Function of Rice Amino Acid Permeases (AAPs).

    Science.gov (United States)

    Taylor, Margaret R; Reinders, Anke; Ward, John M

    2015-07-01

    The transport function of four rice (Oryza sativa) amino acid permeases (AAPs), OsAAP1 (Os07g04180), OsAAP3 (Os06g36180), OsAAP7 (Os05g34980) and OsAAP16 (Os12g08090), was analyzed by expression in Xenopus laevis oocytes and electrophysiology. OsAAP1, OsAAP7 and OsAAP16 functioned, similarly to Arabidopsis AAPs, as general amino acid permeases. OsAAP3 had a distinct substrate specificity compared with other rice or Arabidopsis AAPs. OsAAP3 transported the basic amino acids lysine and arginine well but selected against aromatic amino acids. The transport of basic amino acids was further analyzed for OsAAP1 and OsAAP3, and the results support the transport of both neutral and positively charged forms of basic amino acids by the rice AAPs. Cellular localization using the tandem enhanced green fluorescent protein (EGFP)-red fluorescent protein (RFP) reporter pHusion showed that OsAAP1 and OsAAP3 localized to the plasma membrane after transient expression in onion epidermal cells or stable expression in Arabidopsis. © The Author 2015. Published by Oxford University Press on behalf of Japanese Society of Plant Physiologists. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  3. Did the 2011 AAP recommendations on youth HIV testing change practice? Trends from a large urban adolescent program

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    Seetharaman S

    2017-04-01

    Full Text Available Sujatha Seetharaman,1 Cathryn L Samples,2 Maria Trent3 1Division of Adolescent Medicine, Stanford University Medical Center, Palo Alto, CA, 2Division of Adolescent Medicine, Boston Children’s Hospital, Harvard Medical School, Boston, MA, 3Division of General Pediatrics and Adolescent Medicine, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins School of Medicine, Baltimore, MD, USA Purpose: The purpose of this study was to determine whether there is adherence to the October 2011 American Academy of Pediatrics (AAP recommendations for HIV screening in a large urban adolescent program with availability of a publicly funded program providing free, confidential, sexually transmitted infection (STI and HIV counseling and testing (then rapid or third generation HIV testing, nested in the same adolescent clinic.Methods: We conducted a retrospective chart review of HIV screening trends among 13- to 24-year-old patients tested for HIV during periods of January 2010 to June 2011 (18 months pre-AAP recommendations period and July 2011 to December 2012 (18-month period, which included 15 months after the AAP recommendations.Results: During the period of January 2010 to June 2011, there were 22 tests/1,000 medical visits (N = 824 of 37,520 medical visits, and during the period of July 2011 to December 2012, there were 27 tests/1,000 medical visits (N = 1,068 of 38,763 medical visits (p < 0.0001, odds ratio [OR] 1.26. The number of 13- to 18-year-old patients screened in the pre-AAP period was 150, compared to 297 in the second 18-month period (X2 = 43.3, df = 1, p < 0.0001. A summative risk profile score of 0–9 was created in the form of a continuous variable, with a risk score of 0 for those with no risk factor identified and 1 point for each risk behavior identified. The proportion of HIV test clients with zero-specified risk (a risk score of “0” increased from 2010 to 2012.Conclusion: Release of the 2011 AAP HIV testing guidelines

  4. AAPE proliposomes for topical atopic dermatitis treatment.

    Science.gov (United States)

    Jahn, Alexander; Song, Chung Kil; Balakrishnan, Prabagar; Hong, Soon-Sun; Lee, Ju-Hee; Chung, Suk-Jae; Kim, Dae-Duk

    2014-01-01

    Anti-inflammatory effect of advanced adipose stem cell derived protein extract (AAPE) could be improved by minimising protein degradation. To develop a proliposomal formulation of AAPE for the treatment of topical atopic dermatitis. Proliposomal powder was manufactured by evaporating a solution of soy phosphatidyl choline, AAPE and Poloxamer 407 in ethanol under vacuum on sorbitol powder. Characterisation of proliposomes (zeta potential, diameter, stability and flowability) as well as in vivo efficacy in a dermatitis mouse model was investigated. Reconstitution of the proliposomal powder formed liposomes of 589 ± 3.6 nm diameter with zeta potential of -51.33 ± 0.36 mV. Protein stability was maintained up to 90 days at 25 °C as proliposomes. In vivo studies on atopic dermatitis mouse model showed a significant reduction in IgE levels after topical AAPE proliposome treatment. AAPE proliposomes maintained protein stability and showed promising results for atopic dermatitis treatment.

  5. AAPS, African Political Science and Globalisation: Which Way ...

    African Journals Online (AJOL)

    AAPS, African Political Science and Globalisation: Which Way Forward? L. Adele Jinadu. Abstract. (Af. J. Political Science: 2002 7(2): 1-10). Full Text: EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT · http://dx.doi.org/10.4314/ajps.v7i2.27328 · AJOL African Journals Online.

  6. Milestone Completion Report STCO04-1 AAPS: engagements with code teams, vendors, collaborators, developers

    Energy Technology Data Exchange (ETDEWEB)

    Draeger, E. W. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2017-09-22

    The Advanced Architecture and Portability Specialists team (AAPS) worked with a select set of LLNL application teams to develop and/or implement a portability strategy for next-generation architectures. The team also investigated new and updated programming models and helped develop programming abstractions targeting maintainability and performance portability. Significant progress was made on both fronts in FY17, resulting in multiple applications being significantly more prepared for the nextgeneration machines than before.

  7. Sustainability in the AAP Bronchiolitis Quality Improvement Project.

    Science.gov (United States)

    Shadman, Kristin A; Ralston, Shawn L; Garber, Matthew D; Eickhoff, Jens; Mussman, Grant M; Walley, Susan C; Rice-Conboy, Elizabeth; Coller, Ryan J

    2017-11-01

    Adherence to American Academy of Pediatrics (AAP) bronchiolitis clinical practice guideline recommendations improved significantly through the AAP's multiinstitutional collaborative, the Bronchiolitis Quality Improvement Project (BQIP). We assessed sustainability of improvements at participating institutions for 1 year following completion of the collaborative. Twenty-one multidisciplinary hospital-based teams provided monthly data for key inpatient bronchiolitis measures during baseline and intervention bronchiolitis seasons. Nine sites provided data in the season following completion of the collaborative. Encounters included children younger than 24 months who were hospitalized for bronchiolitis without comorbid chronic illness, prematurity, or intensive care. Changes between baseline-, intervention-, and sustainability-season data were assessed using generalized linear mixed-effects models with site-specific random effects. Differences between hospital characteristics, baseline performance, and initial improvement between sites that did and did not participate in the sustainability season were compared. A total of 2275 discharges were reviewed, comprising 995 baseline, 877 intervention, and 403 sustainability- season encounters. Improvements in all key bronchiolitis quality measures achieved during the intervention season were maintained during the sustainability season, and orders for intermittent pulse oximetry increased from 40.6% (95% confidence interval [CI], 22.8-61.1) to 79.2% (95% CI, 58.0- 91.3). Sites that did and did not participate in the sustainability season had similar characteristics. BQIP participating sites maintained improvements in key bronchiolitis quality measures for 1 year following the project's completion. This approach, which provided an evidence-based best-practice toolkit while building the quality-improvement capacity of local interdisciplinary teams, may support performance gains that persist beyond the active phase of the

  8. Changes and Factors Associated With Tobacco Counseling: Results From the AAP Periodic Survey.

    Science.gov (United States)

    McMillen, Robert; O'Connor, Karen G; Groner, Judith; Tanski, Susanne; Park, Elyse R; Klein, Jonathan D

    2017-07-01

    The American Academy of Pediatrics (AAP) advises pediatricians to counsel parents and patients who use tobacco to quit. This study assesses changes in counseling between 2004 and 2010, and factors associated with counseling in 2010. In 2004 and 2010, the Periodic Survey, a national survey of AAP members, inquired about tobacco counseling. Chi-square tests were performed to compare responses by survey year. Bivariate and multivariable analyses examined factors associated with counseling. Similar proportions of pediatricians in both years (N 2004  = 535 and N 2010  = 549) advised adolescents who smoke to quit (85% vs 81%), discussed quitting techniques (34% vs 32%), and recommended nicotine replacement medications (17% vs 18%). More pediatricians in 2010 reported helping patients assess reasons for and against continuing to smoke (56% vs 48%), providing quitting materials (20% vs 15%), and referring patients to cessation programs (18% vs 13%). More pediatricians in 2010 reported providing quitting materials to parents who smoke (14% vs 10%) and referring to smoking cessation programs (16% vs 11%) (all P counsel, with more tobacco prevention training, and routine documentation of patients' tobacco smoke exposure were associated with counseling about cessation. Most pediatricians advised patients and parents who smoke to quit, and these percentages did not change from 2004 to 2010. Although percentages for assisting with cessation did increase for several activities, most pediatricians still do not do so. Opportunities exist to improve clinicians' protection of children from tobacco and tobacco smoke through quit-line referrals, motivational interviewing, and offering medications. Copyright © 2017 Academic Pediatric Association. Published by Elsevier Inc. All rights reserved.

  9. Veracity and rhetoric in paediatric medicine: a critique of Svoboda and Van Howe's response to the AAP policy on infant male circumcision

    NARCIS (Netherlands)

    Morris, Brian J.; Tobian, Aaron A. R.; Hankins, Catherine A.; Klausner, Jeffrey D.; Banerjee, Joya; Bailis, Stefan A.; Moses, Stephen; Wiswell, Thomas E.

    2014-01-01

    In a recent issue of the Journal of Medical Ethics, Svoboda and Van Howe commented on the 2012 change in the American Academy of Pediatrics (AAP) policy on newborn male circumcision, in which the AAP stated that benefits of the procedure outweigh the risks. Svoboda and Van Howe disagree with the AAP

  10. The AAP gene family for amino acid permeases contributes to development of the cyst nematode Heterodera schachtii in roots of Arabidopsis☆

    Science.gov (United States)

    Elashry, Abdelnaser; Okumoto, Sakiko; Siddique, Shahid; Koch, Wolfgang; Kreil, David P.; Bohlmann, Holger

    2013-01-01

    The beet cyst nematode Heterodera schachtii is able to infect Arabidopsis plants and induce feeding sites in the root. These syncytia are the only source of nutrients for the nematodes throughout their life and are a nutrient sink for the host plant. We have studied here the role of amino acid transporters for nematode development. Arabidopsis contains a large number of different amino acid transporters in several gene families but those of the AAP family were found to be especially expressed in syncytia. Arabidopsis contains 8 AAP genes and they were all strongly expressed in syncytia with the exception of AAP5 and AAP7, which were slightly downregulated. We used promoter::GUS lines and in situ RT-PCR to confirm the expression of several AAP genes and LHT1, a lysine- and histidine-specific amino acid transporter, in syncytia. The strong expression of AAP genes in syncytia indicated that these transporters are important for the transport of amino acids into syncytia and we used T-DNA mutants for several AAP genes to test for their influence on nematode development. We found that mutants of AAP1, AAP2, and AAP8 significantly reduced the number of female nematodes developing on these plants. Our study showed that amino acid transport into syncytia is important for the development of the nematodes. PMID:23831821

  11. Autolytic Activity and Plasma Binding Study of Aap, a Novel Minor Autolysin of Streptococcus pneumoniae

    Directory of Open Access Journals (Sweden)

    Ramina Mahboobi

    2016-04-01

    Full Text Available Pneumococcal autolysins are enzymes involved in cell wall turnover and cellular division physiologically. They have been found to be involved in the pneumococcus pathogenesis. The aim of this study was to identify the autolytic activity of Spr1754 as a novel protein of Streptococcus pneumoniae. Moreover, the binding of the recombinant protein to plasma proteins was also determined. The spr1754 gene was amplified by PCR and cloned into the pET21a(+ prokaryotic expression vector. The constructed pET21a(+/spr1754 recombinant plasmid was transformed into E. coli Origami (DE3 and induced using IPTG. The recombinant protein of Spr1754 was purified by Ni-NTA affinity chromatography and confirmed by SDS-PAGE and Western blot analysis using anti-His tag monoclonal antibody. Autolytic activity and the ability of the recombinant protein in binding to plasma proteins were performed using zymogram analysis and western blot, respectively. The spr1754 with expected size was cloned and overexpressed in Escherichia coli Origami (DE3, successfully. After purification of the Spr1754 recombinant protein, the autolytic activity was observed by zymography. Of the four plasma proteins used in this study, binding of lactoferrin to Spr1754 recombinant protein was shown. The Spr1754 recombinant protein has a bifunctional activity, i.e., as being autolysin and lactoferrin binding and designated as Aap (autolytic/ adhesion/ pneumococcus. Nevertheless, characterization of the Aap needs to be followed using gene inactivation and cell wall localization.

  12. SELECTIVE EVALUATION OF TWO URINARY ENZYMES (NAG AND AAP BEFORE AND AFTER UNILATERAL SHOCK WAVE LITHOTRIPSY

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    M. R. Nikoobakht

    2006-09-01

    Full Text Available Biological effects extracorporeal shock wave lithotripsy (ESWL is not precisely known. We have evaluated two urinary enzymes activity N-acetyl-B-D-glucosamine (NAG and alanine amino peptidase (AAP before and after unilateral ESWL as markers for renal parenchymal damage. Forty eight patients with kidney stones (mean age 39 who had presented for the first time or at least one year after their previous lithotripsy underwent ESWL. Urinary specimens were collected before and after first, third and seventh days of lithotripsy and NAG, AAP were evaluated. These enzymes displayed the greatest activity 24 hours after ESWL with significant difference compared to the control group, (P < 0.05 versus 0.02. Elevation of urinary enzymes activity correlated with stone size particularly stones larger than 2 cm. These data suggest that there is some tubular and parenchymal damage induced by ESWL that needs time to get improved. The higher urinary enzyme activity in patients with larger stones ( > 2 cm is probably related to injury resulting from passage of smaller stones, produced after lithotripsy of a large stone, and it is suggested that these patients are treated with a safer procedure.

  13. Synergistic Radiation Protective Effect of Purified Auricularia auricular-judae Polysaccharide (AAP IV with Grape Seed Procyanidins

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    Haina Bai

    2014-12-01

    Full Text Available The aim of this study was to investigate the synergistic antioxidant potential and protective effect of grape seed procyanidins (GSP in combination with Auricularia auricular-judae polysaccharides (AAP IV on radiation injury in splenocytes. Rat splenocyte irradiation resulted in significantly higher apoptosis rate, malondialdehyde (MDA (p < 0.005, reactive oxygen species (ROS (p < 0.01; cell viability, total superoxide dismutase (T-SOD (p < 0.01, catalase (CAT (p < 0.01, glutathione peroxidase (GSH-PX (p < 0.05, activity and glutathione (GSH (p < 0.01 levels were significantly reduced, compared with the control group. “GSP + AAP IV” treatment of rat splenocytes at doses of “GSP (0.3 μg/mL + AAP IV (50 μg/mL” displayed higher radioprotective and antioxidative effects than the administration of either GSP or AAP IV, as evident by lower levels of MDA (p < 0.001 concentration, as well as higher cell viability and T-SOD (p < 0.05, CAT (p < 0.005, GSH-PX (p < 0.01 and GSH content compared to the radiation group. In addition, in vivo studies have shown that “GSP + AAP IV” significantly ameliorated the decrease of spleen index (p < 0.005 and spleen GSH (p < 0.005 levels and significantly inhibited the increase of MDA (p < 0.005 levels of spleen with radiation-induced damage, compared with the non-treated group. The in vivo and in vitro results suggested that GSP and AAP IV have a synergistic protective effect against radiation-induced injury by improving the antioxidant and immunomodulation activities.

  14. Cytokinins and Expression of SWEET, SUT, CWINV and AAP Genes Increase as Pea Seeds Germinate

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    Paula E. Jameson

    2016-12-01

    Full Text Available Transporter genes and cytokinins are key targets for crop improvement. These genes are active during the development of the seed and its establishment as a strong sink. However, during germination, the seed transitions to being a source for the developing root and shoot. To determine if the sucrose transporter (SUT, amino acid permease (AAP, Sugar Will Eventually be Exported Transporter (SWEET, cell wall invertase (CWINV, cytokinin biosynthesis (IPT, activation (LOG and degradation (CKX gene family members are involved in both the sink and source activities of seeds, we used RT-qPCR to determine the expression of multiple gene family members, and LC-MS/MS to ascertain endogenous cytokinin levels in germinating Pisum sativum L. We show that genes that are actively expressed when the seed is a strong sink during its development, are also expressed when the seed is in the reverse role of being an active source during germination and early seedling growth. Cytokinins were detected in the imbibing seeds and were actively biosynthesised during germination. We conclude that, when the above gene family members are targeted for seed yield improvement, a downstream effect on subsequent seed germination or seedling vigour must be taken into consideration.

  15. Cytokinins and Expression of SWEET, SUT, CWINV and AAP Genes Increase as Pea Seeds Germinate.

    Science.gov (United States)

    Jameson, Paula E; Dhandapani, Pragatheswari; Novak, Ondrej; Song, Jiancheng

    2016-12-01

    Transporter genes and cytokinins are key targets for crop improvement. These genes are active during the development of the seed and its establishment as a strong sink. However, during germination, the seed transitions to being a source for the developing root and shoot. To determine if the sucrose transporter (SUT), amino acid permease (AAP), Sugar Will Eventually be Exported Transporter (SWEET), cell wall invertase (CWINV), cytokinin biosynthesis (IPT), activation (LOG) and degradation (CKX) gene family members are involved in both the sink and source activities of seeds, we used RT-qPCR to determine the expression of multiple gene family members, and LC-MS/MS to ascertain endogenous cytokinin levels in germinating Pisum sativum L. We show that genes that are actively expressed when the seed is a strong sink during its development, are also expressed when the seed is in the reverse role of being an active source during germination and early seedling growth. Cytokinins were detected in the imbibing seeds and were actively biosynthesised during germination. We conclude that, when the above gene family members are targeted for seed yield improvement, a downstream effect on subsequent seed germination or seedling vigour must be taken into consideration.

  16. Connecting Source with Sink: The Role of Arabidopsis AAP8 in Phloem Loading of Amino Acids1[OPEN

    Science.gov (United States)

    Santiago, James P.; Tegeder, Mechthild

    2016-01-01

    Allocation of large amounts of nitrogen to developing organs occurs in the phloem and is essential for plant growth and seed development. In Arabidopsis (Arabidopsis thaliana) and many other plant species, amino acids represent the dominant nitrogen transport forms in the phloem, and they are mainly synthesized in photosynthetically active source leaves. Following their synthesis, a broad spectrum of the amino nitrogen is actively loaded into the phloem of leaf minor veins and transported within the phloem sap to sinks such as developing leaves, fruits, or seeds. Controlled regulation of the source-to-sink transport of amino acids has long been postulated; however, the molecular mechanism of amino acid phloem loading was still unknown. In this study, Arabidopsis AMINO ACID PERMEASE8 (AAP8) was shown to be expressed in the source leaf phloem and localized to the plasma membrane, suggesting its function in phloem loading. This was further supported by transport studies with aap8 mutants fed with radiolabeled amino acids and by leaf exudate analyses. In addition, biochemical and molecular analyses revealed alterations in leaf nitrogen pools and metabolism dependent on the developmental stage of the mutants. Decreased amino acid phloem loading and partitioning to sinks led to decreased silique and seed numbers, but seed protein levels were unchanged, demonstrating the importance of AAP8 function for sink development rather than seed quality. Overall, these results show that AAP8 plays an important role in source-to-sink partitioning of nitrogen and that its function affects source leaf physiology and seed yield. PMID:27016446

  17. Slime layer formation and the prevalence of mecA and aap genes in Staphylococcus epidermidis isolates.

    Science.gov (United States)

    Pourmand, Mohammad Reza; Abdossamadi, Zahra; Salari, Mohammad Hossein; Hosseini, Mostafa

    2011-02-01

    Staphylococcus epidermidis strains are frequently associated with catheter-related infection, acute bacteremia, and hospital-acquired infection. Some isolates produce an extracellular matrix called slime that may make them more resistant to antibiotics. The aim of this study was to determine antimicrobial resistance patterns, the prevalence of slime production, and the distribution of genes (mecA and aap, respectively) associated with these phenotypes in S. epidermidis nasal isolates from health-care personnel. A descriptive cross-sectional study was performed on 163 nasal swabs from health-care staff (one swab per subject). S. epidermidis isolates were tested for slime production on congo red agar and antibiotic resistance. PCR-based screening for mecA and aap genes was performed upon the extracted DNA of S. epidermidis isolates. A total of 99 S. epidermidis strains were cultured from 58.9% of the study participants (n = 96). Of these strains, 34 (34.3%) isolates produced slime. A significant relation between slime production and resistance to penicillin 32(94%) , oxacillin 30(88%), tetracycline 20(59%), erythromycin 27(79%), and clindamycin 26(77%) was found. Respectively, 95.8% and 94.8% of all isolates were PCR-positive for mecA and aap, but only 59.8% of mecA+ strains were oxacillin-resistant and 37.3% of aap+ strains were slime producers. The surveillance of nasal colonization with slime-forming oxacillin-resistant S. epidermidis in health-care workers might be helpful in breaking the epidemiological chain of hospital-acquired infections.

  18. Do high-risk preschoolers or overweight mothers meet AAP-recommended behavioral goals for reducing obesity?

    Science.gov (United States)

    Turer, Christy Boling; Stroo, Marissa; Brouwer, Rebecca J; Krause, Katrina M; Lovelady, Cheryl A; Bastian, Lori A; Peterson, Bercedis; Østbye, Truls

    2013-01-01

    The American Academy of Pediatrics (AAP) has issued specific behavioral recommendations to prevent obesity. It is unclear how often high-risk preschoolers and overweight mothers meet recommended behavior goals and whether meeting these goals is negatively associated with overweight/obesity. To describe the proportion of preschoolers and mothers that meet AAP-recommended behavior goals and examine the associations of meeting goals with weight-status, and mothers meeting goals and children meeting corresponding goals. Secondary analysis of baseline data (before an intervention) from mother-preschooler dyads in a weight-control study. Mothers were overweight or obese. Preschoolers were 2-5 years old. Dietary and feeding practices were assessed by the use of questionnaires. Activity was measured directly using accelerometry. Outcomes included preschooler overweight and maternal obesity. The respective proportions of children and mothers that met behavior goals were: 17% and 13% for ≥5 fruits/vegetables/day, 46% and 33% for zero sugar-sweetened beverages/day, 41% and 13% for fast-food meeting each goal when mothers met the corresponding goal. Few high-risk preschoolers or overweight mothers meet AAP-recommended behavior goals. Meeting a greater number of behavior goals may be particularly important for maternal weight. Preschoolers have greater odds of meeting behavior goals when mothers meet behavior goals. Copyright © 2013 Academic Pediatric Association. Published by Elsevier Inc. All rights reserved.

  19. Role of the two-component regulatory system arlRS in ica operon and aap positive but non-biofilm-forming Staphylococcus epidermidis isolates from hospitalized patients.

    Science.gov (United States)

    Wu, Yang; Liu, Jingran; Jiang, Juan; Hu, Jian; Xu, Tao; Wang, Jiaxue; Qu, Di

    2014-11-01

    The ica operon and aap gene are important factors for Staphylococcus epidermidis biofilm formation. However, we found 15 out of 101 S. epidermidis strains isolated from patients had both the ica operon and the aap gene in the genome but could not form biofilms (ica(+)aap(+)/BF(-) isolates). Compared with standard strain RP62A, the 15 ica(+)aap(+)/BF(-) isolates had similar growth curves and initial attachment abilities, but had much lower apparent transcription levels of the icaA gene and significantly less production of polysaccharide intercellular adhesion (PIA). Furthermore, the expression of accumulation-associated protein in ica(+)aap(+)/BF(-) isolates was much weaker than in RP62A. The mRNA levels of icaADBC transcription-related regulatory genes, including icaR, sarA, rsbU, srrA, arlRS and luxS, were measured in the 15 ica(+)aap(+)/BF(-) clinical isolates. The mRNA levels of arlR and rsbU in all of the ica(+)aap(+)/BF(-) isolates were lower than in RP62A at 4 h. At 10 h, 14/15 of the isolates showed lower mRNA levels of arlR and rsbU than shown by RP62A. However, expression of sarA, luxS, srrA and icaR varied in different ica(+)aap(+)/BF(-) isolates. To further investigate the role of arlRS in biofilm formation, we analyzed icaA, sarA and rsbU transcription, PIA synthesis, Aap expression and biofilm formation in an arlRS deletion mutant of S. epidermidis strain 1457 and all were much less than in the wild type strain. This is consistent with the hypothesis that ArlRS may play an important role in regulating biofilm formation by the ica(+)aap(+)/BF(-)S. epidermidis clinical isolates and operate via both ica-dependent and Aap-dependent pathways. Copyright © 2014 Elsevier Ltd. All rights reserved.

  20. Distribution of Pathogenic Genes aatA, aap, aggR, among Uropathogenic Escherichia coli (UPEC) and Their Linkage with StbA Gene.

    Science.gov (United States)

    Nazemi, A; Mirinargasi, M; Merikhi, N; Sharifi, S H

    2011-07-01

    Urinary tract infection (UTI) with E. coli (UPEC) is one of the most common bacterial infections among human beings. In addition to the host predisposing factors, genes are also proposed to have an important role in the occurrence of UTIs. This study investigated the distribution of three pathogenic genes including aggR, aap and aatA among UPEC infected samples and their linkage with stbA, the essential gene for maintaining of pAA plasmid. A total of 244 samples were collected from patients with UTIs through clinical laboratories located in western side of Tehran (Iran) during years 2008-2009. E. coli isolation was performed according to standard laboratory methods. DNAs were extracted from samples using Boiling method, and the presence of aap, aggR, aatA and stbA genes were investigated by PCR. No pathogenic genes (aap, aggR, aatA) were found in 104 out of 244 UPEC samples, while 14 of them were carrying stbA gene. Out of 140 UPEC samples with pathogenic genes, 94 (46.6%) were carrying aap gene, 52 (23%) aggR gene, and 80 (35.4%) aatA gene. A total of 18 samples were also carrying all pathogenic genes together. Moreover, 44 out of 144 samples were carrying stbA gene. The results obtained by this study showed that the aggR, aap and aatA pathogenic genes have different existence patterns in different E. coli strains that infect different organs. Our study also showed that these three plasmid genes in EAEC strains are able to transpose in the genome and change their level of linkage with pAA plasmid essential gene stbA. Meanwhile, this study confirmed that aggR, aap and aatA genes are not specific to only EAEC strains.

  1. Opposite effects of cell differentiation and apoptosis on Ap3A/Ap4A ratio in human cell cultures.

    Science.gov (United States)

    Vartanian, A; Prudovsky, I; Suzuki, H; Dal Pra, I; Kisselev, L

    1997-09-29

    The biological role of diadenosine oligophosphates (DAOP) remains obscure in spite of numerous attempts to solve this enigma. It is known that Ap3A contrary to Ap4A accumulates in human cultured cells treated with interferons (IFNs) alpha or gamma. Since IFNs are considered as antiproliferative regulators, we assumed that different cell status may be associated with varying intracellular levels of DAOP. Promyelocytic human cell line HL60 induced by phorbol ester (TPA) to differentiate to macrophage-like cells in culture exhibits a profound loss of proliferative potential. Here we have shown a 4-5-fold increase in Ap3A concentration in HL60 cells induced by TPA, similar to the effect of IFN, while the Ap4A concentration remained unchanged. On the contrary, in cells undergoing apoptosis induced by VP16, a topoisomerase II inhibitor, the Ap3A concentration considerably decreased, while the Ap4A concentration increased. These findings combined with earlier results suggest an involvement of the Ap3A/Ap4A ratio in signal transduction pathways controlling the cell status.

  2. Periodontal regeneration - intrabony defects: a consensus report from the AAP Regeneration Workshop.

    Science.gov (United States)

    Reynolds, Mark A; Kao, Richard T; Camargo, Paulo M; Caton, Jack G; Clem, Donald S; Fiorellini, Joseph P; Geisinger, Maria L; Mills, Michael P; Nares, Salvador; Nevins, Marc L

    2015-02-01

    is possible on previously diseased root surfaces, as evidenced by a gain in clinical attachment, decreased pocket probing depth, gain in radiographic bone height, and overall improvement in periodontal health. These clinical findings are consistent with available histologic evidence. Clinical improvements can be maintained over long periods (>10 years). Although bone replacement grafts have been the most commonly investigated modality, GTR, biologics, and combination therapies have also been shown to be effective. Future research should emphasize patient-reported outcomes, individual response differences, and emerging technologies to enhance treatment results. Early management of intrabony defects with regenerative therapies offers the greatest potential for successful periodontal regeneration. The clinical selection and application of a regenerative therapy or combination of therapies for periodontal regeneration should be based on the clinician's experiences and understanding of the regenerative biology and technology. This decision-making process should take into consideration the potential adverse influence of factors, such as smoking, poor oral hygiene, tooth mobility, and defect morphology, on regeneration. Management should be coupled with an effective maintenance program for long-term success.

  3. Clinical Management of ADHD in a Family Medicine Residency Program: Comparison with AAP Guidelines.

    Science.gov (United States)

    Skelley, Jessica W; Carpenter, P Chase; Morehead, M Shawn; Murphy, Patrick L

    2016-06-01

    Attention-deficit/hyperactivity disorder (ADHD) is the most common neurobehavioral disorder. Research has shown that even with the growing incidence of children diagnosed as having ADHD, physicians may find providing optimal care to these patients challenging. Our objective was to contrast existing clinical management of ADHD in a family medicine setting with published American Academy of Pediatrics guidelines and review the literature pertinent to differences. A report was generated for all visits with "ADHD" or "ADD" (attention-deficit disorder) as a current or past medical problem that had been addressed at the family medicine clinic from July 2012 to June 2014. A total of 60 pediatric patients were identified. A retrospective chart review of clinical practice and management patterns for these patients was completed using a standardized data collection form based on the 2011 ADHD treatment guidelines set by the American Academy of Pediatrics. Fifty-seven (95%) patients had documentation of at least one core symptom of ADHD, and 27 (45%) patients had documentation of these symptoms in more than one setting (clinic/school/home). Only 30 (50%) patients were assessed at the initial ADHD visit for coexisting conditions. Coexisting conditions were found to be present in 20 (33.3%) patients. Of these 20 patients, coexisting conditions were not addressed during the visit in 12 (60%) patients before drug therapy for ADHD was initially prescribed. Behavioral therapy was initiated as first-line monotherapy in one of the nine preschool-age patients (4-5 years old). Fifty-two (86.7%) patients received a preferred initial medication as identified by guidelines, and 41 (78.8%) of those patients received an appropriate initial dose. Fifty-one (85%) patients were assessed for improvement of symptoms, and 39 (65%) were assessed for adverse events. Of 62 documented medication adjustments, 54 (87.1%) adjustments coincided with current practice guidelines. Sixteen (26.7%) patients were referred to mental health specialists. This retrospective review identified areas of strength and weakness for attending physicians and medical residents in the diagnosis, evaluation, and treatment of children with ADHD. A significant need was identified for more physician-focused education on the evaluation of coexisting conditions and long-term management associated with ADHD therapy. Further training in the initiation of behavioral therapy as a first-line treatment above drug therapy and proper medication selection in children aged 4 to 5 years also are recommended.

  4. AAP Updates Recommendations on Car Seats

    Science.gov (United States)

    ... trip in every type of transportation, on the road or in the air,” Dr. Durbin said. Click here for a list of approved car safety seats. Healthy Children Radio: Car Seat Safety Dennis Durbin, MD, FAAP, ...

  5. Automated Assessment of Postural Stability (AAPS)

    Science.gov (United States)

    2016-10-01

    resolution of the Kinect with respect to movements and postures that are relevant to the physical therapy community. Importantly, our observation...4 42 k Ac tu al E xp en di tu re : ~$ 38 4k U pd at ed : 3 0 O ct ob er 2 01 6 Ti m el in e an d C os t Ac tiv iti es

  6. Automated Assessment of Postural Stability (AAPS)

    Science.gov (United States)

    2017-10-01

    individual trial started with the subject facing the sensor with their arms spread out perpendicularly and their feet spread out shoulder width (the “T...one leg with hands resting on hips, while tandem stance entails standing with one foot directly in front of the other with hands resting on hips...subject is unable to keep his or her hands resting on their hip. The system performance analysis begins with a comparison between the Kinect-measured

  7. Lawrence Berkeley Laboratory Affirmative Action Program. Revised

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-06-01

    The Lawrence Berkeley Laboratory`s Affirmative Action Program (AAP) serves as a working document that describes current policies, practices, and results in the area of affirmative action. It represents the Laboratory`s framework for an affirmative approach to increasing the representation of people of color and women in segments of our work force where they have been underrepresented and taking action to increase the employment of persons with disabilities and special disabled and Vietnam era veterans. The AAP describes the hierarchy of responsibility for Laboratory affirmative action, the mechanisms that exist for full Laboratory participation in the AAP, the policies and procedures governing recruitment at all levels, the Laboratory`s plan for monitoring, reporting, and evaluating affirmative action progress, and a description of special affirmative action programs and plans the Laboratory has used and will use in its efforts to increase the representation and retention of groups historically underrepresented in our work force.

  8. Periodontal soft tissue non-root coverage procedures: a systematic review from the AAP Regeneration Workshop.

    Science.gov (United States)

    Kim, David M; Neiva, Rodrigo

    2015-02-01

    Gingival augmentation procedures around natural teeth and dental implants are performed to facilitate plaque control, to improve patient comfort, to prevent future recession, and in conjunction with restorative, orthodontic, or prosthetic dentistry. The aim of this study is to answer the most common questions related to this treatment modality based on the most relevant and current knowledge in the field. Two reviewers worked to answer the five most common and clinically relevant questions with supporting literature to understand the role of gingiva around teeth. 1) What circumstances require an increased zone of keratinized tissue (KT), or is KT important? 2) What is the ideal thickness of an autogenous gingival graft? Is a thick autogenous gingival graft more effective than a thin autogenous gingival graft? 3) What are the alternatives to autogenous gingival grafting to increase the zone of attached gingiva? 4) Does orthodontic intervention affect soft tissue health and dimensions? 5) What is the patient-reported patient outcome for minimal KT compared with that for an enhanced zone of KT? An extensive literature search was performed using PubMed, the Cochrane Oral Health Group Specialized Trials Registry (the Cochrane Library), and the most respected journals in the field. Although gingival augmentation procedures were first introduced in 1960s, there have not been in-depth comparative studies examining the five questions that have been proposed by the authors. Lack of relevant systematic reviews and randomized clinical trials (RCTs) on this topic do not allow authors to answer those questions with a strong level of evidence. However, the following can be recommended after reviewing case reports and case series on these topics. 1) There is enough clinical evidence to support maintaining an adequate band of gingiva for intracrevicular margin restoration. 2) Thick grafts do not appear to result in better clinical outcomes than thin grafts. Thick grafts are likely to result in more primary contraction, whereas thin grafts tend to be prone to secondary contraction. 3) Viable alternative treatment modalities are currently available that are capable of providing KT augmentation without the need for palatal donor tissue. 4) Appropriately applied orthodontic forces do not cause permanent damage to a healthy periodontium. The probability of recession during tooth movement in thin biotype is high to justify gingival augmentation when the dimension of gingiva is inadequate. In addition, cases in which there will be a facial tooth movement outside of the alveolar process need to be considered for a gingival augmentation procedure. 5) Although the articles that have been published on this topic did not consider patient-reported outcomes and esthetics as part of the overall treatment success assessment, patients who have received alternative treatment modalities that did not depend on palatal tissue harvesting appear to have reported more satisfaction and less discomfort after treatment. Autogenous gingival grafts are still considered to be the "gold standard" procedure with unmatched success rates and clinical success when gingival augmentation procedures are required. However, tissue-engineered materials may offer viable options to palatal tissue harvesting for gingival augmentation. KT augmentation may prevent the development and progression of gingival recession, especially when restorative margins may interact with the periodontium and/or orthodontic treatment is indicated. Patient-reported outcomes should be considered for future studies on this topic. Additional RCTs and systematic reviews are needed to support these conclusions.

  9. Emerging Regenerative Approaches for Periodontal Reconstruction: Practical Applications From the AAP Regeneration Workshop

    Science.gov (United States)

    Rios, Hector F.; Bashutski, Jill D.; McAllister, Bradley S.; Murakami, Shinya; Cobb, Charles M.; Chun, Yong-Hee Patricia; Lin, Zhao; Mandelaris, George A.; Cochran, David L.

    2015-01-01

    Focused Clinical Question Can emerging technologies for periodontal regeneration become clinical reality? Summary Emerging technologies are presenting options to hopefully improve the outcomes of regeneration in challenging clinical scenarios. Cellular allografts represent a current technology in which cells and scaffolds are being delivered directly to the periodontal lesion. Recombinant human fibroblast growth factor 2 and teriparatide (parathyroid 1–34) have each been tested in controlled prospective human randomized clinical trials, and both have been shown to have potential for periodontal regeneration. These examples, as well as other emerging technologies, show promise for continued advancement in the field of periodontal regenerative therapy. Conclusions At present, there are indications that emerging technologies can be used successfully for periodontal regeneration. Case reports and clinical trials are being conducted with a variety of emerging technologies. However, many are yet to be approved by a regulatory agency, or there is a lack of evidence-based literature to validate their expanded use. PMID:26146593

  10. Emerging regenerative approaches for periodontal reconstruction: a systematic review from the AAP Regeneration Workshop.

    Science.gov (United States)

    Lin, Zhao; Rios, Hector F; Cochran, David L

    2015-02-01

    More than 30 years have passed since the first successful application of regenerative therapy for treatment of periodontal diseases. Despite being feasible, periodontal regeneration still faces numerous challenges, and complete restoration of structure and function of the diseased periodontium is often considered an unpredictable task. This review highlights developing basic science and technologies for potential application to achieve reconstruction of the periodontium. A comprehensive search of the electronic bibliographic database PubMed was conducted to identify different emerging therapeutic approaches reported to influence either biologic pathways and/or tissues involved in periodontal regeneration. Each citation was assessed based on its abstract, and the full text of potentially eligible reports was retrieved. Based on the review of the full papers, their suitability for inclusion in this report was determined. In principle, only reports from scientifically well-designed studies that presented preclinical in vivo (animal studies) or clinical (human studies) evidence for successful periodontal regeneration were included. Hence, in vitro studies, namely those conducted in laboratories without any live animals, were excluded. In case of especially recent and relevant reviews with a narrow focus on specific regenerative approaches, they were identified as such, and thereby the option of referring to them to summarize the status of a specific approach, in addition to or instead of listing each separately, was preserved. Admittedly, the presence of subjectivity in the selection of studies to include in this overview cannot be excluded. However, it is believed that the contemporary approaches described in this review collectively represent the current efforts that have reported preclinical or clinical methods to successfully enhance regeneration of the periodontium. Today's challenges facing periodontal regenerative therapy continue to stimulate important research and clinical development, which, in turn, shapes the current concept of periodontal tissue engineering. Emerging technologies--such as stem cell therapy, bone anabolic agents, genetic approaches, and nanomaterials--also offer unique opportunities to enhance the predictability of current regenerative surgical approaches and inspire development of novel treatment strategies.

  11. Scientific impact of presentations from the EURAPS and the AAPS meetings

    DEFF Research Database (Denmark)

    Khorasani, Hoda; Lassen, Mats Højbjerg; Kuzon, William

    2017-01-01

    -2009) were analyzed. A search using PubMed and Google Scholar was performed to obtain publication status of each presentation as of 2014 (observation period: 5 years). Data were analyzed according to subspecialty. Weighted chi-square was used to examine differences in publication rates for the two societies...

  12. Die aap in jou koffie: Afrikaanse epo- nieme van A tot Z. Anton F ...

    African Journals Online (AJOL)

    In 'n onlangse radio-onderhoud sê Anton. Prinsloo dat hy probeer om 'n woordeboek per jaar te lewer; vir 2011 lewer hy die eerste eponiemwoordeboek vir Afrikaans. In hierdie woordeboek vertel Prinsloo die etimologiese verhaal van ongeveer 2000 woorde in Afri- kaans wat almal op een of ander manier herlei kan word ...

  13. Resensie: "Die aap in jou koffie: Afrikaanse eponieme van A tot Z ...

    African Journals Online (AJOL)

    : Protea Boekhuis, 2011. 352 pp. ISBN: 978-1-86919-463-5. Full Text: EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT · http://dx.doi.org/10.4314/tvl.v50i1.13 · AJOL African Journals ...

  14. Review of an Atlas of Pediatric Surgery in the Tropics (AAPS)

    African Journals Online (AJOL)

    to be carried about and big enough to accommodate the contents. The choice of hardcover was well thought out; bearing in mind the frequent references it would ... of pediatric surgery in the tropics. Generally, well-structured up to date with short and succinct chapters superbly referenced. The book can assist the surgeon ...

  15. Periodontal soft tissue non-root coverage procedures: a consensus report from the AAP Regeneration Workshop.

    Science.gov (United States)

    Scheyer, E Todd; Sanz, Mariano; Dibart, Serge; Greenwell, Henry; John, Vanchit; Kim, David M; Langer, Laureen; Neiva, Rodrigo; Rasperini, Giulio

    2015-02-01

    Soft tissue grafting for the purposes of increasing the width of keratinized tissue (KT) is an important aspect of periodontal treatment. A systematic review was analyzed, focusing on non-root coverage tissue grafts. The references were updated to reflect the current literature. To formulate the consensus report, group members submitted any new literature related to the topic that met criteria fitting the systematic review, and this information was reviewed for inclusion in this report. A consensus report was developed to summarize the findings from the systematic review and to guide clinicians in their treatment decision-making process. Forty-six articles met the criteria for inclusion in the final analysis, and two articles were added that were used to formulate this consensus report. A list of eight clinically relevant questions was posed, and consensus statements were developed. The evidence suggests that a minimum amount of KT is not needed to prevent attachment loss (AL) when optimal plaque control is present. However, if plaque control is suboptimal, a minimum of 2 mm of KT is needed. The standard procedure to predictably gain KT is the autogenous gingival graft. There is limited evidence for alternative treatment options. However, additional research may offer promising results in certain clinical scenarios. Before patient treatment, the clinician should evaluate etiology, including the role of inflammation and various types of trauma that contribute to AL. The best outcome procedure (autograft) and alternative options should be reviewed with the patient during appropriate informed consent. Proper assessment of the outcome should be included during supportive periodontal care.

  16. Cultural bias in the AAP's 2012 Technical Report and Policy Statement on male circumcision

    DEFF Research Database (Denmark)

    Frisch, Morten; Aigrain, Yves; Barauskas, Vidmantas

    2013-01-01

    urinary tract infections in infant boys, which can easily be treated with antibiotics without tissue loss. The other claimed health benefits, including protection against HIV/AIDS, genital herpes, genital warts, and penile cancer, are questionable, weak, and likely to have little public health relevance...

  17. Response to Vogelstein: How the 2012 AAP Task Force on circumcision went wrong.

    Science.gov (United States)

    Van Howe, Robert S

    2017-07-09

    Vogelstein cautions medical organizations against jumping into the fray of controversial issues, yet proffers the 2012 American Academy of Pediatrics' Task Force policy position on infant male circumcision as 'an appropriate use of position-statements.' Only a scratch below the surface of this policy statement uncovers the Task Force's failure to consider Vogelstein's many caveats. The Task Force supported the cultural practice by putting undeserved emphasis on questionable scientific data, while ignoring or underplaying the importance of valid contrary scientific data. Without any effort to quantitatively assess the risk/benefit balance, the Task Force concluded the benefits of circumcision outweighed the risks, while acknowledging that the incidence of risks was unknown. This Task Force differed from other Academy policy-forming panels by ignoring the Academy's standard quality measures and by not appointing members with extensive research experience, extensive publications, or recognized expertise directly related to this topic. Despite nearly 100 publications available at the time addressing the substantial ethical issues associated with infant male circumcision, the Task Force chose to ignore the ethical controversy. They merely stated, with minimal justification, the opinion of one of the Task Force members that the practice of infant male circumcision is morally permissible. The release of the report has fostered an explosion of academic discussion on the ethics of infant male circumcision with a number of national medical organizations now decrying the practice as a human rights violation. © 2017 John Wiley & Sons Ltd.

  18. The child neurology clinical workforce in 2015: Report of the AAP/CNS Joint Taskforce.

    Science.gov (United States)

    Kang, Peter B; Bale, James F; Mintz, Mark; Joshi, Sucheta M; Gilbert, Donald L; Radabaugh, Carrie; Ruch-Ross, Holly

    2016-09-27

    More than a decade has passed since the last major workforce survey of child neurologists in the United States; thus, a reassessment of the child neurology workforce is needed, along with an inaugural assessment of a new related field, neurodevelopmental disabilities. The American Academy of Pediatrics and the Child Neurology Society conducted an electronic survey in 2015 of child neurologists and neurodevelopmental disabilities specialists. The majority of respondents participate in maintenance of certification, practice in academic medical centers, and offer subspecialty care. EEG reading and epilepsy care are common subspecialty practice areas, although many child neurologists have not had formal training in this field. In keeping with broader trends, medical school debts are substantially higher than in the past and will often take many years to pay off. Although a broad majority would choose these fields again, there are widespread dissatisfactions with compensation and benefits given the length of training and the complexity of care provided, and frustrations with mounting regulatory and administrative stresses that interfere with clinical practice. Although not unique to child neurology and neurodevelopmental disabilities, such issues may present barriers for the recruitment of trainees into these fields. Creative approaches to enhance the recruitment of the next generation of child neurologists and neurodevelopmental disabilities specialists will benefit society, especially in light of all the exciting new treatments under development for an array of chronic childhood neurologic disorders. © 2016 American Academy of Neurology.

  19. Periodontitis and systemic diseases : a record of discussions of working group 4 of the Joint EFP/AAP Workshop on Periodontitis and Systemic Diseases

    NARCIS (Netherlands)

    Linden, Gerry J; Herzberg, Mark C; van Winkelhoff, Arie

    BACKGROUND: There has been an explosion in research into possible associations between periodontitis and various systemic diseases and conditions. AIM: To review the evidence for associations between periodontitis and various systemic diseases and conditions, including chronic obstructive pulmonary

  20. Economic Evaluation of Carbon Adsorption/Ion Exchange Wastewater Treatment Options for Sunflower AAP (Army Ammunition Plant) NQ (Nitroguanidine) Wastewater Treatment Facility

    Science.gov (United States)

    1987-07-31

    quality to be used as boiler feedwater. % % . Process options using mechanical vapor recompression ( MVR ) either as an lvv add-on or an alternative to...separator with rotary valve for discharging dried salts, main blower and dust control equipment. The system also includes a tube conveyor, a dried-salt...brine at 10 wt.% and 215 oF. System consists of gas-fired burner, V ,. atomizer with driver, drying chamber, ,,’ . exhaust blower , cyclone and rotary

  1. Draamateatris müüakse pähkleid, aga ükski ei taha osta / Priit Pedajas ; interv. Aap Egorov

    Index Scriptorium Estoniae

    Pedajas, Priit, 1954-

    1999-01-01

    Eesti Draamateatris Madis Kõivu näidend "Kui me Moondsundi Vasseliga kreeka pähkleid kauplesime, siis ükski ei tahtnud osta", lavastaja Priit Pedajas, kunstnik Pille Jänes, osades Ita Ever, Andrus Vaarik, Ain Lutsepp, Rein Oja, Laine Mägi, Kersti Kreismann jt. Esietendus 9. juunil

  2. Potential for Using Acetic Acid Plus Pear Ester Combination Lures to Monitor Codling Moth in an SIT Program

    Directory of Open Access Journals (Sweden)

    Gary J. R. Judd

    2016-11-01

    Full Text Available Studies were conducted in commercial apple orchards in British Columbia, Canada, to determine whether lures combining ethyl-(E,Z-2,4-decadienoate, pear ester (PE, with either acetic acid (AA or sex pheromone, (E,E-8,10-dodecadien-1-ol (codlemone, might improve monitoring of codling moth, Cydia pomonella (L., in an area-wide programme integrating sterile insect technology (SIT and mating disruption (MD. Catches of sterile and wild codling moths were compared in apple orchards receiving weekly delivery of sterile moths (1:1 sex ratio using white delta traps baited with either AA or PE alone, and in combination. Sterile and wild codling moths responded similarly to these kairomone lures. For each moth sex and type (sterile and wild, AA-PE lures were significantly more attractive than AA or PE alone. Bisexual catches with AA-PE lures were compared with those of commercial bisexual lures containing 3 mg of codlemone plus 3 mg of PE (Pherocon CM-DA Combo lure, Trécé Inc., Adair, OK, USA, and to catches of males with standard codlemone-loaded septa used in SIT (1 mg and MD (10 mg programmes, respectively. CM-DA lures caught the greatest number of sterile and wild male moths in orchards managed with SIT alone, or combined with MD, whereas AA-PE lures caught 2–3× more females than CM-DA lures under both management systems. Sterile to wild (S:W ratios for male versus female moths in catches with AA-PE lures were equivalent, whereas in the same orchards, male S:W ratios were significantly greater than female S:W ratios when measured with CM-DA lures. Male S:W ratios measured with CM-DA lures were similar to those with codlemone lures. CM-DA and codlemone lures appear to overestimate S:W ratios as measured by AA-PE lures, probably by attracting relatively more sterile males from long range. Using AA-PE lures to monitor codling moths in an SIT programme removes fewer functional sterile males and reduces the need for trap maintenance compared with using

  3. Purification and characterization of novel cationic peroxidases from Asparagus acutifolius L. with biotechnological applications.

    Science.gov (United States)

    Guida, Vincenzo; Cantarella, Maria; Chambery, Angela; Mezzacapo, Maria C; Parente, Augusto; Landi, Nicola; Severino, Valeria; Di Maro, Antimo

    2014-08-01

    Four novel basic peroxidases, named AaP-1, AaP-2, AaP-3, and AaP-4, were purified from Asparagus acutifolius L. seeds by cation-exchange and gel filtration chromatographies. The four proteins showed a similar electrophoretic mobility of 46 kDa while, by MALDI-TOF MS, different Mr values of 42758.3, 41586.9, 42796.3, and 41595.5 were determined for AaP-1, AaP-2, AaP-3, and AaP-4, respectively. N-terminal sequences of AaPs 1-4 up to residue 20 showed a high percentage of identity with the peroxidase from Glycine max. In addition, AaP-1, AaP-2, AaP-3, and AaP-4 were found to be glycoproteins, containing 21.75, 22.27, 25.62, and 18.31 % of carbohydrates, respectively. Peptide mapping and MALDI-TOF MS analysis of AaPs 1-4 showed that the structural differences between AaP-1 and AaP-2 and AaP-3 and AaPs-4 were mainly due to their glycan content. We also demonstrate that AaPs were able to remove phenolic compounds from olive oil mill wastewaters with a higher catalytic efficiency with respect to horseradish peroxidase, thus representing candidate enzymes for potential biotechnological applications in the environmental field.

  4. Neonatal hearing screening program in Ahvaz, Southern Iran

    Directory of Open Access Journals (Sweden)

    Marzieh Amiri

    2014-01-01

    Full Text Available Background and Aim: American Academy of Pediatrics (AAP established standards for neonatal hearing screening programs in 1999. The main purpose of this study was to achieve exact statistical data of this program in Ahvaz, Iran, and to compare these results with the standards of American Academy of Pediatrics.Methods: In this cross-sectional descriptive study, the data of neonatal hearing program in Ahvaz west health center from 2008 to 2011 were reviewed. Data were analysed by descriptive statistics.Results: From 25073 neonates, 25 had hearing loss. The false positive and referral ratio to the diagnosis stage were 2.6 and 0.48 percent, respectively. 92 percent of hard of hearing infants were diagnosed before three months of life.Conclusion: In comparison with the standards of American Academy of Pediatrics, all of the items, except two, were included completely or relatively complete. But, more efforts must be done to achieve the whole standards which are available.

  5. Evaluation of Six Options for Obtaining Red Water

    National Research Council Canada - National Science Library

    Pfetzing, E; Hoye, R

    1993-01-01

    .... The AEC is conducting a research and development program to select and demonstrate the best available treatment technology for red water in support of environmental compliance at Army ammunition plants (AAPs...

  6. NCBI nr-aa BLAST: CBRC-DYAK-08-0041 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-DYAK-08-0041 gb|AAP31709.1| NADH dehydrogenase subunit 2 [Microgale longicauda...ta] gb|AAP31710.1| NADH dehydrogenase subunit 2 [Microgale longicaudata] gb|AAP31711.1| NADH dehydrogenase subunit 2 [Microgale longicaudata] AAP31709.1 1.2 21% ...

  7. Effect of ultrasonic treatment on immunological activities of polysaccharides from adlay.

    Science.gov (United States)

    Yao, Yang; Zhu, Yingying; Gao, Yue; Ren, Guixing

    2015-09-01

    Alkali-extractable polysaccharides from the seed of adlay and their two polysaccharide sub-fractions (AAP-1 and AAP-2) were isolated and purified by anion-exchange and gel filtration chromatography. Ultrasonic treatment was put in place to obtain AAP-1' and AAP-2'. Average molecular weights (Mws) of AAP-1, AAP-1', AAP-2, and AAP-2' were 94.2 kDa, 63.1 kDa, 82.3 kDa, and 60.4 kDa, respectively. Monosaccharides composition analysis indicated that AAP-1 and AAP-1' were composed of Rha, Ara, Glc, and Gal in a molar ratio of 1.1:0.4:0.7:0.5 and 1.4:1.6:0.4:0.7. AAP-2 and AAP-2' were composed of Xyl, Rha, Gal and Glc in a molar percent of 0.4:1.4:1.6:0.5 and 0.3:1.6:1.1:0.7. In vitro study showed that AAP-1, AAP-1', AAP-2, and AAP-2' were all able to encourage the production of secretory molecules (NO, TNF-α and IL-6) of RAW264.7 murine macrophages in concentrations determines manner. AAP-2' seemed to be the most potent and induced significantly higher the NO production. These findings suggest that the ultrasonic polysaccharides isolated in our study have immune potentiation effects on macrophages and should serve as a beneficial health food. Copyright © 2015 Elsevier B.V. All rights reserved.

  8. Advanced Avionics and Processor Systems for a Flexible Space Exploration Architecture

    Science.gov (United States)

    Keys, Andrew S.; Adams, James H.; Smith, Leigh M.; Johnson, Michael A.; Cressler, John D.

    2010-01-01

    The Advanced Avionics and Processor Systems (AAPS) project, formerly known as the Radiation Hardened Electronics for Space Environments (RHESE) project, endeavors to develop advanced avionic and processor technologies anticipated to be used by NASA s currently evolving space exploration architectures. The AAPS project is a part of the Exploration Technology Development Program, which funds an entire suite of technologies that are aimed at enabling NASA s ability to explore beyond low earth orbit. NASA s Marshall Space Flight Center (MSFC) manages the AAPS project. AAPS uses a broad-scoped approach to developing avionic and processor systems. Investment areas include advanced electronic designs and technologies capable of providing environmental hardness, reconfigurable computing techniques, software tools for radiation effects assessment, and radiation environment modeling tools. Near-term emphasis within the multiple AAPS tasks focuses on developing prototype components using semiconductor processes and materials (such as Silicon-Germanium (SiGe)) to enhance a device s tolerance to radiation events and low temperature environments. As the SiGe technology will culminate in a delivered prototype this fiscal year, the project emphasis shifts its focus to developing low-power, high efficiency total processor hardening techniques. In addition to processor development, the project endeavors to demonstrate techniques applicable to reconfigurable computing and partially reconfigurable Field Programmable Gate Arrays (FPGAs). This capability enables avionic architectures the ability to develop FPGA-based, radiation tolerant processor boards that can serve in multiple physical locations throughout the spacecraft and perform multiple functions during the course of the mission. The individual tasks that comprise AAPS are diverse, yet united in the common endeavor to develop electronics capable of operating within the harsh environment of space. Specifically, the AAPS tasks for

  9. Metabolic Signature of Antipsychotics Used in the Treatment of Autism

    Science.gov (United States)

    2015-10-01

    Atypical antipsychotics (AAP) are prescribed to patients with autism spectrum disorders with symptoms of aggression or agitation, stereotypic behavior...Atypical antipsychotics (AAP) are used chronically to treat millions of pediatric, adult, and geriatric patients with schizophrenia , bipolar disorder

  10. application of ascorbic acid 2-phosphate as a new voltammetric

    African Journals Online (AJOL)

    a

    ) using ascorbic acid 2-phosphate (AAP) as a new voltammetric substrate has been described in this paper. In the alkaline buffer solution the ALP enzymatic hydrolysis product of AAP was ascorbic acid (AA), which was an electro-active ...

  11. NCBI nr-aa BLAST: CBRC-OANA-01-1968 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-OANA-01-1968 gb|AAP13045.1| NADH dehydrogenase subunit 2 [Pseudochaenichthys georg...ianus] gb|AAP13046.1| NADH dehydrogenase subunit 2 [Pseudochaenichthys georgianus] AAP13045.1 0.17 23% ...

  12. NCBI nr-aa BLAST: CBRC-AGAM-02-0007 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-AGAM-02-0007 gb|AAP56247.1| deltamethrin resistance-associated NYD-OP1 [Culex ...pipiens pallens] gb|AAP56248.1| deltamethrin resistance-associated NYD-OP2 [Culex pipiens pallens] AAP56247.1 0.0 86% ...

  13. NCBI nr-aa BLAST: CBRC-AGAM-02-0015 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-AGAM-02-0015 gb|AAP56247.1| deltamethrin resistance-associated NYD-OP1 [Culex ...pipiens pallens] gb|AAP56248.1| deltamethrin resistance-associated NYD-OP2 [Culex pipiens pallens] AAP56247.1 0.0 86% ...

  14. NCBI nr-aa BLAST: CBRC-AGAM-02-0008 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-AGAM-02-0008 gb|AAP56247.1| deltamethrin resistance-associated NYD-OP1 [Culex ...pipiens pallens] gb|AAP56248.1| deltamethrin resistance-associated NYD-OP2 [Culex pipiens pallens] AAP56247.1 0.0 86% ...

  15. NCBI nr-aa BLAST: CBRC-AGAM-02-0007 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-AGAM-02-0007 gb|AAP56249.1| deltamethrin resistance-associated NYD-OP3 [Culex ...pipiens pallens] gb|AAP56250.1| deltamethrin resistance-associated NYD-OP4 [Culex pipiens pallens] AAP56249.1 0.0 86% ...

  16. NCBI nr-aa BLAST: CBRC-AGAM-02-0005 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-AGAM-02-0005 gb|AAP56249.1| deltamethrin resistance-associated NYD-OP3 [Culex ...pipiens pallens] gb|AAP56250.1| deltamethrin resistance-associated NYD-OP4 [Culex pipiens pallens] AAP56249.1 1e-178 81% ...

  17. NCBI nr-aa BLAST: CBRC-AGAM-02-0015 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-AGAM-02-0015 gb|AAP56249.1| deltamethrin resistance-associated NYD-OP3 [Culex ...pipiens pallens] gb|AAP56250.1| deltamethrin resistance-associated NYD-OP4 [Culex pipiens pallens] AAP56249.1 0.0 86% ...

  18. NCBI nr-aa BLAST: CBRC-AGAM-02-0008 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-AGAM-02-0008 gb|AAP56249.1| deltamethrin resistance-associated NYD-OP3 [Culex ...pipiens pallens] gb|AAP56250.1| deltamethrin resistance-associated NYD-OP4 [Culex pipiens pallens] AAP56249.1 0.0 86% ...

  19. NCBI nr-aa BLAST: CBRC-OCUN-01-0785 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-OCUN-01-0785 gb|AAP41476.1| immediate early protein ICP0 [Cercopithecine herpe...svirus 1] gb|AAP41493.1| immediate early protein ICP0 [Cercopithecine herpesvirus 1] AAP41476.1 0.029 31% ...

  20. Effect Effects of Auricularia auricula Polysaccharides on Exhaustive ...

    African Journals Online (AJOL)

    results suggest that AAPs have anti-fatigue activity and could enhance exercise endurance. Effect of AAPs on serum, muscle, and liver. MDA levels. Similar to the effect on performance in the exhaustive swimming test, AAPs also exerted a significant effect on MDA levels as demonstrated in Fig. 2. Serum MDA levels of mice ...

  1. NCBI nr-aa BLAST: CBRC-ATHA-05-0006 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-ATHA-05-0006 gb|AAP45159.1| Plant viral-response family protein [Solanum bulbo...castanum] gb|AAP45189.1| Plant viral-response family protein [Solanum bulbocastanum] AAP45159.1 4e-13 23% ...

  2. Respiratory health effects of ambient air pollution: an update.

    Science.gov (United States)

    Sava, Francesco; Carlsten, Chris

    2012-12-01

    There is new evidence for ambient air pollution (AAP) leading to an increased incidence of respiratory diseases in adults. Research has demonstrated that co-exposures have the potential to dramatically augment the effects of AAP and lower the threshold of effect of a given pollutant. Interactions between genes related to oxidative stress and AAP seem to significantly alter the effect of AAP on an individual and population basis. A better definition of vulnerable populations may bolster local or regional efforts to remediate AAP. Advances in genetic research tools have the potential to identify candidate genes that can guide further research. Copyright © 2012 Elsevier Inc. All rights reserved.

  3. Serial Ultrasound Monitoring for Early Recognition of Asparaginase Associated Pancreatitis in Children With Acute Lymphoblastic Leukemia

    DEFF Research Database (Denmark)

    Raja, Raheel Altaf; Schmiegelow, K.; Henriksen, Birthe Merete

    2015-01-01

    protocol, with PEG-asparaginase of 2 or 6 week intervals, for 30 weeks had their pancreas monitored using serial ultrasound in order to detect early signs of inflammation. RESULTS: Nineteen of 31 eligible patients were included. Three of the included patients developed AAP. None of the patients, including...... the three patients that developed AAP, had signs of inflammatory edema or pancreas enzymes above three times the upper normal limit prior to AAP. CONCLUSION: We found no signs of inflammatory edema within the pancreas on ultrasound during treatment with PEG-asparginase in our cohort prior to development...... of AAP or in patients that did not develop AAP....

  4. Advanced Avionics and Processor Systems for Space and Lunar Exploration

    Science.gov (United States)

    Keys, Andrew S.; Adams, James H.; Ray, Robert E.; Johnson, Michael A.; Cressler, John D.

    2009-01-01

    NASA's newly named Advanced Avionics and Processor Systems (AAPS) project, formerly known as the Radiation Hardened Electronics for Space Environments (RHESE) project, endeavors to mature and develop the avionic and processor technologies required to fulfill NASA's goals for future space and lunar exploration. Over the past year, multiple advancements have been made within each of the individual AAPS technology development tasks that will facilitate the success of the Constellation program elements. This paper provides a brief review of the project's recent technology advancements, discusses their application to Constellation projects, and addresses the project's plans for the coming year.

  5. Developing pictorial asthma action plans to promote self-management and health in rural youth with asthma: A qualitative study.

    Science.gov (United States)

    Duncan, Christina L; Walker, Heather A; Brabson, Laurel; Williford, Desireé N; Hynes, Lisa; Hogan, Mary Beth

    2017-09-21

    Asthma action plans (AAPs) provide asthma management instructions to families; however, AAPs typically are written at a 7th-9th grade reading level, making them less useful in lower literacy families. There is a need to develop simpler AAP formats and content to optimize their utility across all families, including those who are rural and may be at a risk for literacy concerns. Because using pictures can simplify and enhance health education, our study's aim was to develop a pictorial AAP through a series of focus groups with key stakeholders - youth with asthma, caregivers, and physicians. Fourteen caregiver/youth dyads and four physicians participated in separate focus groups where their preferences for pictorial AAP structure and content were obtained. Focus groups were audio recorded, transcribed, coded with ATLAS.ti, and analyzed for themes. Youth and their caregivers prefer that the AAPs include simple, cartoon-like pictures customized to the patient. Physicians emphasized AAP's capability to display pictures of controller medication given its importance in preventing asthma exacerbations. A stoplight format, currently used in most written AAPs, received positive reviews. Specific suggestions for pictures showing symptoms, medications, and how to take medication were suggested. Words and short phrases accompanying the pictures were thought to add clarity. Key stakeholders viewed pictorial AAPs as positive and potentially effective alternatives to standard written AAPs. It is expected that low literacy youth and caregivers would more easily understand a pictorial AAP presentation, which should facilitate better medication adherence and asthma outcomes in these children.

  6. Adeno-associated Virus (AAV) Assembly-Activating Protein Is Not an Essential Requirement for Capsid Assembly of AAV Serotypes 4, 5, and 11.

    Science.gov (United States)

    Earley, Lauriel F; Powers, John M; Adachi, Kei; Baumgart, Joshua T; Meyer, Nancy L; Xie, Qing; Chapman, Michael S; Nakai, Hiroyuki

    2017-02-01

    Adeno-associated virus (AAV) vectors have made great progress in their use for gene therapy; however, fundamental aspects of AAV's capsid assembly remain poorly characterized. In this regard, the discovery of assembly-activating protein (AAP) sheds new light on this crucial part of AAV biology and vector production. Previous studies have shown that AAP is essential for assembly; however, how its mechanistic roles in assembly might differ among AAV serotypes remains uncharacterized. Here, we show that biological properties of AAPs and capsid assembly processes are surprisingly distinct among AAV serotypes 1 to 12. In the study, we investigated subcellular localizations and assembly-promoting functions of AAP1 to -12 (i.e., AAPs derived from AAV1 to -12, respectively) and examined the AAP dependence of capsid assembly processes of these 12 serotypes using combinatorial approaches that involved immunofluorescence and transmission electron microscopy, barcode-Seq (i. e., a high-throughput quantitative method using DNA barcodes and a next-generation sequencing technology), and quantitative dot blot assays. This study revealed that AAP1 to -12 are all localized in the nucleus with serotype-specific differential patterns of nucleolar association; AAPs and assembled capsids do not necessarily colocalize; AAPs are promiscuous in promoting capsid assembly of other serotypes, with the exception of AAP4, -5, -11, and -12; assembled AAV5, -8, and -9 capsids are excluded from the nucleolus, in contrast to the nucleolar enrichment of assembled AAV2 capsids; and, surprisingly, AAV4, -5, and -11 capsids are not dependent on AAP for assembly. These observations highlight the serotype-dependent heterogeneity of the capsid assembly process and challenge current notions about the role of AAP and the nucleolus in capsid assembly. Assembly-activating protein (AAP) is a recently discovered adeno-associated virus (AAV) protein that promotes capsid assembly and provides new opportunities

  7. 48 CFR 307.104 - General procedures.

    Science.gov (United States)

    2010-10-01

    ... monitoring. (4) The HCA/CCO and Small Business Specialist (SBS) in the Office of Small and Disadvantaged Business Utilization (OSDBU) shall review the AAP at least quarterly, with input from the cognizant program.... As appropriate, the discussions shall include— (1) Determining the intended acquisition strategy and...

  8. Accumulation-Associated Protein Enhances Staphylococcus epidermidis Biofilm Formation under Dynamic Conditions and Is Required for Infection in a Rat Catheter Model

    Science.gov (United States)

    Schaeffer, Carolyn R.; Woods, Keith M.; Longo, G. Matt; Kiedrowski, Megan R.; Paharik, Alexandra E.; Büttner, Henning; Christner, Martin; Boissy, Robert J.; Horswill, Alexander R.; Rohde, Holger

    2014-01-01

    Biofilm formation is the primary virulence factor of Staphylococcus epidermidis. S. epidermidis biofilms preferentially form on abiotic surfaces and may contain multiple matrix components, including proteins such as accumulation-associated protein (Aap). Following proteolytic cleavage of the A domain, which has been shown to enhance binding to host cells, B domain homotypic interactions support cell accumulation and biofilm formation. To further define the contribution of Aap to biofilm formation and infection, we constructed an aap allelic replacement mutant and an icaADBC aap double mutant. When subjected to fluid shear, strains deficient in Aap production produced significantly less biofilm than Aap-positive strains. To examine the in vivo relevance of our findings, we modified our previously described rat jugular catheter model and validated the importance of immunosuppression and the presence of a foreign body to the establishment of infection. The use of our allelic replacement mutants in the model revealed a significant decrease in bacterial recovery from the catheter and the blood in the absence of Aap, regardless of the production of polysaccharide intercellular adhesin (PIA), a well-characterized, robust matrix molecule. Complementation of the aap mutant with full-length Aap (containing the A domain), but not the B domain alone, increased initial attachment to microtiter plates, as did in trans expression of the A domain in adhesion-deficient Staphylococcus carnosus. These results demonstrate Aap contributes to S. epidermidis infection, which may in part be due to A domain-mediated attachment to abiotic surfaces. PMID:25332125

  9. Safe Sleep Infant Care Practices Reported by Mothers of Twins.

    Science.gov (United States)

    Damato, Elizabeth G; Haas, Madeline C; Czeck, Pamela; Dowling, Donna A; Barsman, Sarah Gutin

    2016-12-01

    The high prevalence of prematurity and low birth-weight places twin infants at increased risk for sudden unexpected infant death (SUID) and/or sudden infant death syndrome (SIDS). Risk for these SUID and SIDS is affected by a combination of nonmodifiable intrinsic risk factors and modifiable extrinsic stressors including infant care practices related to sleep. Although adherence to the full scope of American Academy of Pediatrics (AAP) 2011 recommendations is intended to decrease risk, these recommendations are aimed at singleton infants and may require tailoring for families with multiple infants. The study describes infant care practices reported by mothers of twins in the first 6 months postpartum. Mothers caring for twin infants (N = 35) were surveyed online both longitudinally (at 2, 8, 16, and 24 weeks after infant hospital discharge) and cross-sectionally. AAP recommendations (2011) guided survey content. The degree of adherence to AAP recommendations varied over time. For example, mothers of twins reported 100% adherence to placing twins supine for sleep initially, but many reported putting babies on their stomachs for naps as twins became older. Sharing a parent's bedroom decreased over time as did frequency of crib sharing. Fewer than half of mothers offered a pacifier most or all of the time for sleep. Opportunities exist for development of an educational program geared specifically for postpartum parents of twins. Barriers affecting adherence to AAP recommendations and effectiveness of educational programs addressing needs of this unique population need further exploration.

  10. Early childhood adversity, toxic stress, and the role of the pediatrician: translating developmental science into lifelong health.

    Science.gov (United States)

    Garner, Andrew S; Shonkoff, Jack P

    2012-01-01

    Advances in a wide range of biological, behavioral, and social sciences are expanding our understanding of how early environmental influences (the ecology) and genetic predispositions (the biologic program) affect learning capacities, adaptive behaviors, lifelong physical and mental health, and adult productivity. A supporting technical report from the American Academy of Pediatrics (AAP) presents an integrated ecobiodevelopmental framework to assist in translating these dramatic advances in developmental science into improved health across the life span. Pediatricians are now armed with new information about the adverse effects of toxic stress on brain development, as well as a deeper understanding of the early life origins of many adult diseases. As trusted authorities in child health and development, pediatric providers must now complement the early identification of developmental concerns with a greater focus on those interventions and community investments that reduce external threats to healthy brain growth. To this end, AAP endorses a developing leadership role for the entire pediatric community-one that mobilizes the scientific expertise of both basic and clinical researchers, the family-centered care of the pediatric medical home, and the public influence of AAP and its state chapters-to catalyze fundamental change in early childhood policy and services. AAP is committed to leveraging science to inform the development of innovative strategies to reduce the precipitants of toxic stress in young children and to mitigate their negative effects on the course of development and health across the life span.

  11. Analysis of Advantages and Disadvantages of the Location Methods of International Auricular Acupuncture Points

    Directory of Open Access Journals (Sweden)

    Pei-Jing Rong

    2016-01-01

    Full Text Available The international standardization of auricular acupuncture points (AAPs is an important basis for auricular therapy or auricular diagnosis and treatment. The study on the international standardization of AAPs has gone through a long process, in which the location method is one of the key research projects. There are different points of view in the field of AAPs among experts from different countries or regions. By only analyzing the nine representative location methods, this paper tried to offer a proper location method to locate AAPs. Through analysis of the pros and cons of each location method, the location method applied in the WFAS international standard of AAPs is thoroughly considered as an appropriate method. It is important to keep the right direction during developing an International Organization for Standardization (ISO international standard of auricular acupuncture points and to improve the research quality of international standardization for AAPs.

  12. Analysis of Advantages and Disadvantages of the Location Methods of International Auricular Acupuncture Points

    OpenAIRE

    Pei-Jing Rong; Jing-Jun Zhao; Lei Wang; Li-Qun Zhou

    2016-01-01

    The international standardization of auricular acupuncture points (AAPs) is an important basis for auricular therapy or auricular diagnosis and treatment. The study on the international standardization of AAPs has gone through a long process, in which the location method is one of the key research projects. There are different points of view in the field of AAPs among experts from different countries or regions. By only analyzing the nine representative location methods, this paper tried to o...

  13. Blonanserin Augmentation of Atypical Antipsychotics in Patients with Schizophrenia-Who Benefits from Blonanserin Augmentation?: An Open-Label, Prospective, Multicenter Study

    OpenAIRE

    Woo, Young Sup; Park, Joo Eon; Kim, Do-Hoon; Sohn, Inki; Hwang, Tae-Yeon; Park, Young-Min; Jon, Duk-In; Jeong, Jong-Hyun; Bahk, Won-Myong

    2016-01-01

    Objective The purpose of this study was to investigate the efficacy and tolerability of atypical antipsychotics (AAPs) with augmentation by blonanserin in schizophrenic patients. Methods aA total of 100 patients with schizophrenia who were partially or completely unresponsive to treatment with an AAP were recruited in this 12-week, open-label, non-comparative, multicenter study. Blonanserin was added to their existing AAP regimen, which was maintained during the study period. Efficacy was pri...

  14. [Giant pulmonary artery aneurysm: etiology and an exceptional 17 years natural course].

    Science.gov (United States)

    Anzouan-Kacou, J-B; Séka, R; N'guetta, R; Kramoh, E; Konin, C

    2015-04-01

    True pulmonary artery aneurysm (AAP) is rare and represent less than 1% of intra-thoracic aneurysms. We report a case of a AAP in a patient with a likely cor triatrium sinister, with an obstructive membrane responsible for pulmonary hypertension, explaining AAP. The long-term evolution of 17 years is made to an uncomplicated myocardial infarction. The patient died eight months later suddenly probably due to the rupture of the PAA. Copyright © 2014 Elsevier Masson SAS. All rights reserved.

  15. Auricularia auricular polysaccharide-low molecular weight chitosan polyelectrolyte complex nanoparticles: Preparation and characterization

    Directory of Open Access Journals (Sweden)

    Wei Xiong

    2016-06-01

    Full Text Available Novel polyelectrolyte complex nanoparticles (AAP/LCS NPs were prepared in this study and these were produced by mixing negatively charged auricularia auricular polysaccharide (AAP with positively charged low molecular weight chitosan (LCS in an aqueous medium. The AAP was extracted and purified from auricularia auricular, and then characterized by micrOTOF-Q mass spectrometry, UV/Vis spectrophotometry, moisture analyzer and SEM. The yield, moisture, and total sugar content of the AAP were 4.5%, 6.2% and 90.12% (w/w, respectively. The AAP sample was water-soluble and exhibited white flocculence. The characteristics of AAP/LCS NPs, such as the particle size, zeta potential, morphology, FT-IR spectra, DSC were investigated. The results obtained revealed that the AAP/LCS NPs had a spherical shape with a diameter of 223 nm and a smooth surface, and the results of the FT-IR spectra and DSC investigations indicated that there was an electrostatic interaction between the two polyelectrolyte polymers. Bovine serum albumin (BSA, pI = 4.8 and bovine hemoglobin (BHb, pI = 6.8 were used as model drugs to investigate the loading and release features of the AAP/LCS NPs. The results obtained showed that the AAP/LCS NPs had a higher entrapment efficiency (92.6% for BHb than for BSA (81.5%. The cumulative release of BSA and BHb from AAP/LCS NPs after 24 h in vitro was 95.4% and 91.9%, respectively. The in vitro release demonstrated that AAP/LCS NPs provided a sustained release matrix suitable for the delivery of protein drugs. These studies demonstrate that AAP/LCS NPs have a very promising potential as a delivery system for protein drugs.

  16. Complexes of Rhenium(V) with Aminoacetopehenones and their ...

    African Journals Online (AJOL)

    Complexes of rhenium(V) with 2-, 3- and 4-aminoacetophenone (H2aap) have been synthesized. The reaction of trans-ReOCl3(PPh3)2 with 2-H2aap in benzene yielded the imido complex [Re(2-aap)Cl3(PPh3)], in which the oxo oxygen and one of the PPh3 groups were substituted by the dianionic imido nitrogen and the ...

  17. Qualitative and quantitative analysis of the effects of acetaminophen and N-acetylcysteine on the surface morphology of Hep3B hepatoma cells in vitro.

    Science.gov (United States)

    Levanon, Daniel; Manov, Irena; Iancu, Theodore C

    2004-01-01

    Acetaminophen (AAP) is harmful to the liver if consumed in excessive doses. Its toxicity can be counteracted by N-acetylcysteine (NAC). The authors studied cultures of Hep3B cells exposed to AAP or NAC or both, at 24 and 48 h, using the scanning electron microscope. Using morphometric software, they found that cultures exposed for 24 h to AAP or AAP + NAC suffered reduction in cell confluence. Exposure increased the incidence of rounding cells and of apoptotic and autoschizic appearances. Differences between control cultures cultivated without serum versus those exposed to xenobiotics were merely quantitative, not essential.

  18. Acetaminophen hepatotoxicity and mechanisms of its protection by N-acetylcysteine: a study of Hep3B cells.

    Science.gov (United States)

    Manov, Irena; Hirsh, Mark; Iancu, Theodore C

    2002-02-01

    Acetaminophen (AAP) hepatotoxicity, resulting in centrilobular necrosis, is frequently encountered following suicidal attempts, especially by adolescents, but also after its excessive use in infants. The subcellular and molecular sequences leading to hepatocellular cell death are not yet clear. We therefore investigated AAP hepatotoxicity by using cultured hepatoma-derived cells (Hep3B) exposed to AAP and N-acetylcysteine (NAC), used as a protective agent. Specifically, we studied the role of apoptosis and oxidative damage as putative mechanisms of AAP-associated cytotoxicity. Hep3B cells were exposed to AAP (5-25 mM) and NAC (5 mM) for different time periods. Cell viability was assessed by the Alamar Blue Reduction Test and LDH. Oxidative damage was evaluated by measuring reactive oxygen species (ROS) and glutathione. AAP-induced apoptosis was investigated by flow cytometry and transmission electron microscopy. We found that: 1. In Hep3B cells, AAP causes a time- and concentration-dependent cytotoxic effect, leading to oxidative stress, mitochondrial dysfunction, alterations of membrane permeability and apoptosis; 2. In the course of AAP cytotoxicity, the generation of ROS appears as an early event which precedes decrease of viability, LDH leakage, glutathione depletion and apoptosis; 3. NAC protects Hep3B cells from AAP-induced oxidative injury, but does not prevent apoptosis.

  19. Complexes of rhenium(V with aminoacetophenones and their reactions with some bidentate ligands

    Directory of Open Access Journals (Sweden)

    G. Bandoli

    2002-12-01

    Full Text Available Complexes of rhenium(V with 2-, 3- and 4-aminoacetophenone (H2aap have been synthesized. The reaction of trans-ReOCl3(PPh32 with 2-H2aap in benzene yielded the imido complex [Re(2-aapCl3(PPh3], in which the oxo oxygen and one of the PPh3 groups were substituted by the dianionic imido nitrogen and the neutral ketonic oxygen, respectively. With 3- and 4-H2aap the imido complexes trans-[Re(aapCl3(PPh32] were isolated. The monodentate coordination mode of these latter two ligands was authenticated by the X-ray crystal structure of trans-[Re(3-aapCl3(PPh32]; crystals are triclinic, P1, with a = 10.567(5, b = 11.989(6, c = 18.739(8 Å, α = 74.82(4°, β = 75.27(4°, γ= 73.15(4°, U = 2152(2 Å3, Z = 2, R = 0.0469. The further reaction of [Re(3-aapCl3(PPh32] with the bidentate ligands 2-aminophenol and 8-hydroxyquinoline (HL led to the isolation of complexes of the type [Re(3-aapCl2(PPh3(L]. However, with 1,2-diaminobenzene (H2dab, the 3-aap imido moiety was displaced by the imido group {N(C6H4NH2}, to give the complex trans-[Re(dabCl3(PPh32].

  20. PRECIPITATION EFFECTS ON SOIL CHARACTERISTICS IN TROPICAL RAIN FORESTS OF THE CHOCO BIOGEOGRAPHICAL REGION

    Directory of Open Access Journals (Sweden)

    Harley Quinto Mosquera

    2016-01-01

    Full Text Available Average annual precipitation (AAP is one of the principal environmental factors that regulates processes in terrestrial ecosystems. The effect of AAP on the availability of edaphic nutrients is poorly understood, especially in tropical zones with high rainfall. In order to evaluate the effects of high AAP on the availability of soil N, P, and K, physicochemical parameters were measured in soils of three tropical rainforests in the Chocó biogeographical region with different AAPs (7,500, 8,000, and 10,000 mm yr-1. Furthermore, a bibliographical review was carried out that including studies for distinct tropical Ultisols and AAP ranging from 1,800 to 10,000 mm yr-1. The evaluated soils presented extreme acidity with high contents of Al, organic matter (OM and total N, and low quantities of P, Mg, and Ca. The K concentrations were intermediate and the effective cation exchange capacity (ECEC was low. On the other hand, in the evaluation of the influence of the AAP on the availability of N, P, and K in the soil, contrasting tendencies were observed. On one side, a positive curvilinear relationship was found between the availability of N and the increase in the AAP. On the other side, the available P content significantly decreased with increasing AAP. In conclusion, the excessive AAP resulted in increases in total N and low availability of P, thereby altering the dynamics of the nutrients and the carbon balance of the tropical forest

  1. Single-cell activity of freshwater aerobic anoxygenic phototrophic bacteria and their contribution to biomass production

    National Research Council Canada - National Science Library

    Garcia-Chaves, Maria C; Cottrell, Matthew T; Kirchman, David L; Ruiz-González, Clara; Del Giorgio, Paul A

    2016-01-01

    Aerobic anoxygenic phototrophic (AAP) bacteria are photoheterotrophs that despite their low abundances have been hypothesized to play an ecologically and biogeochemically important role in aquatic systems...

  2. Functional Relationship Between Phytoplankton and Aerobic Anoxygenic Photosynthetic Bacteria: Modes of Coexistence

    Science.gov (United States)

    Kolber, Z. S.; Haffa, A.; Klimov, D.

    2006-12-01

    Aerobic Anoxygenic Photosynthetic Bacteria (AAPs) are ubiquitously distributed in the upper ocean. Although they contain bacteriochlorophyll a (BChla), the main absorption bands in the near UV (370 nm) and infrared (800-850 nm) make this pigment impractical in light harvesting below the first few meters of the water column. Instead, they utilize carotenoids as major light harvesting pigments. Since these carotenoids absorb in the 430-550 nm range, phytoplankton and AAPs utilize a similar portion of the available light spectrum. As AAPs cannot utilize water as the electron donor, they transfer electrons between a range of organic/inorganic electron donors and electron acceptors, thus significantly participating in the redox cycle in the upper ocean. We have measured the vertical distribution and photosynthetic properties of both phytoplankton and AAPs in a highly oligotrophic region 800 km SW of Monterey Bay (34N, 129W), and we have consistently observed the presence of a BChla maximum about 30 to 40 meters above the chlorophyll maximum, indicating that phytoplankton and AAPs occupy different ecological niches in the water column. However, the abundance of AAPs generally displayed a maximum at dawn and a minimum at the dusk, indicating a high level of mortality. This diel cycle was observed in 5 micron and 3 micron size fractions, indicating active grazing by small protists. Incubation experiments with natural, mixed population of AAPs and phytoplankton results in an unusually high accumulation of AAPs in DCMU-treated samples, indicating that pigmented protists do contribute significantly to AAP grazing in a tightly-controlled microbial loop. On the other hand, AAP incubations in pure cultures indicate that they biomineralize sulfur, thus affecting the sulfur cycle. All of these observations indicate that the role of AAPs in the upper ocean ecology is defined by their relationship with phototrophic and heterotrophic communities, rather than by their relative

  3. Food security policies and family farm in Brazil: actors, ideas and institutions

    Directory of Open Access Journals (Sweden)

    Georges FLEXOR

    2016-12-01

    Full Text Available This article analyzes the formulation of two food security policies –the Food Acquisition Program (aap and the National School Food Program (neap– emphasizing the role of ideas, interests and institutions. The establishment of aap dates back to the 2003, a period characterized by the implementation of the policy Fome Zero (Zero Hunger, a public action which was the flagship of Luiz Inácio «Lula» da Silva first mandate policies to fight poverty. This program aims to promote food security based on family farm supply. These ideas, the actors and the institutions that have shaped this policies were also the basis for the reformulation of the neap. In this sense, this article provides not only an analysis of two policies that are the object of transfer to other countries (Latin America and Africa, but also a «portrait» –limited, but informative– of a political juncture of Brazilian history. 

  4. Relevance of Assembly-Activating Protein for Adeno-associated Virus Vector Production and Capsid Protein Stability in Mammalian and Insect Cells.

    Science.gov (United States)

    Grosse, Stefanie; Penaud-Budloo, Magalie; Herrmann, Anne-Kathrin; Börner, Kathleen; Fakhiri, Julia; Laketa, Vibor; Krämer, Chiara; Wiedtke, Ellen; Gunkel, Manuel; Ménard, Lucie; Ayuso, Eduard; Grimm, Dirk

    2017-10-15

    The discovery that adeno-associated virus 2 (AAV2) encodes an eighth protein, called assembly-activating protein (AAP), transformed our understanding of wild-type AAV biology. Concurrently, it raised questions about the role of AAP during production of recombinant vectors based on natural or molecularly engineered AAV capsids. Here, we show that AAP is indeed essential for generation of functional recombinant AAV2 vectors in both mammalian and insect cell-based vector production systems. Surprisingly, we observed that AAV2 capsid proteins VP1 to -3 are unstable in the absence of AAP2, likely due to rapid proteasomal degradation. Inhibition of the proteasome led to an increase of intracellular VP1 to -3 but neither triggered assembly of functional capsids nor promoted nuclear localization of the capsid proteins. Together, this underscores the crucial and unique role of AAP in the AAV life cycle, where it rapidly chaperones capsid assembly, thus preventing degradation of free capsid proteins. An expanded analysis comprising nine alternative AAV serotypes (1, 3 to 9, and rh10) showed that vector production always depends on the presence of AAP, with the exceptions of AAV4 and AAV5, which exhibited AAP-independent, albeit low-level, particle assembly. Interestingly, AAPs from all 10 serotypes could cross-complement AAP-depleted helper plasmids during vector production, despite there being distinct intracellular AAP localization patterns. These were most pronounced for AAP4 and AAP5, congruent with their inability to rescue an AAV2/AAP2 knockout. We conclude that AAP is key for assembly of genuine capsids from at least 10 different AAV serotypes, which has implications for vectors derived from wild-type or synthetic AAV capsids.IMPORTANCE Assembly of adeno-associated virus 2 (AAV2) is regulated by the assembly-activating protein (AAP), whose open reading frame overlaps with that of the viral capsid proteins. As the majority of evidence was obtained using virus

  5. The evaluation of dryland Cenchrus ciliaris l. cv Molopo for weaner ...

    African Journals Online (AJOL)

    Weaner calf production from a dryland C. ciliaris pasture was evaluated at three stocking rates under continuous grazing (1978 -1983). Differences in available above ground phytomass (AAP) weaning mass and economic returns were investigated. The AAP decreased with increased stocking rates. At the high and medium ...

  6. A plasma membrane association module in yeast amino acid transporters

    NARCIS (Netherlands)

    Popov-Čeleketić, Dušan; Bianchi, Frans; Ruiz, Stephanie J; Meutiawati, Febrina; Poolman, Bert

    2016-01-01

    Amino acid permeases (AAPs) in the plasma membrane (PM) of Saccharomyces cerevisiae are responsible for the uptake of amino acids and involved in regulation of their cellular levels. Here, we report on a strong and complex module for PM association found in the C-terminal tail of AAPs. Using in

  7. Asparaginase-associated pancreatitis: a study on phenotype and genotype in the NOPHO ALL2008 protocol

    DEFF Research Database (Denmark)

    Wolthers, B. O.; Frandsen, Thomas L.; Abrahamsson, Jonas

    2016-01-01

    Asparaginase (ASP)-associated pancreatitis (AAP) occurs during acute lymphoblastic leukemia treatment. Among 1285 children (1.0-17.9 years) diagnosed during July 2008-December 2014 and treated according to the Nordic/Baltic ALL2008 protocol, 86 (cumulative incidence = 6.8%) developed AAP. Seventy...

  8. 75 FR 22234 - Phosphate Ester, Tallowamine, Ethoxylated; Exemption from the Requirement of a Tolerance

    Science.gov (United States)

    2010-04-28

    ...; wetting, spreading, and dispersing agents; propellants in aerosol dispensers; microencapsulating agents..., there was no evidence that AAPs are mutagenic or clastogenic. There are no chronic toxicity or... expected to be immunotoxic and, there was no evidence that the AAPs are mutagenic or clastogenic. ii. No...

  9. Enzymuria in neonates receiving continuous intravenous infusion of gentamicin

    DEFF Research Database (Denmark)

    Colding, H; Brygge, K; Brendstrup, L

    1992-01-01

    with non-treatment periods in the same newborn infant (33 infants). The same tendency applied to AAP. Newborn infants receiving continuous intravenous infusion of gentamicin were not found to be at greater risk of nephrotoxicity than those receiving intermittent gentamicin treatment, using NAG and AAP...

  10. Increasing availability to and ascertaining value of asthma action plans in schools through use of technology and community collaboration.

    Science.gov (United States)

    Hanson, Tabitha K; Aleman, Martha; Hart, Lacey; Yawn, Barbara

    2013-12-01

    Approximately 9% of school-aged children in the United States have asthma. Since 1997, the Asthma Action Plan (AAP) has been recommended as an asthma self-management tool for individuals with asthma. In the school setting, the use of the AAP has been primarily dependent on communication between the family and the school through a paper process. To address the limited availability of AAPs, the Southeast Minnesota Beacon Project developed and implemented a secure portal designed for the electronic exchange of the AAP between providers and schools. This project was designed to assess school nurses' responses to the portal and the perceived value of AAPs, efficiency, self-efficacy, and project impact. School nurses perceive that the AAP enables more efficient management of the care of students with asthma and increases school nurse self-efficacy in regard to asthma management. Overall, school nurses felt the AAP portal was useful and they reported satisfaction with its function as a school health office resource. Electronic sharing of the AAP has the potential to increase efficiency and enhance effective communication among health care providers, families, and schools. © 2013, American School Health Association.

  11. Diagnostic value of plain abdominal radiographs in acute ...

    African Journals Online (AJOL)

    Objective: The plain film of the abdomen (PAX) is still utilised in the diagnosis of acute appendicitis (Aap). Aim of this study was to evaluate the value of PAX in the diagnosis of Aap in children, since it continues to be a controversial subject. Design: A retrospective study. Setting: Department of Paediatric Surgery, Gazi ...

  12. NCBI nr-aa BLAST: CBRC-FCAT-01-0751 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-FCAT-01-0751 gb|AAP36136.1| Homo sapiens cholinergic receptor, muscarinic 1 [s...ynthetic construct] gb|AAX29286.1| cholinergic receptor muscarinic 1 [synthetic construct] gb|AAX29287.1| cholinergic receptor muscarinic 1 [synthetic construct] AAP36136.1 0.0 98% ...

  13. NCBI nr-aa BLAST: CBRC-OPRI-01-0897 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-OPRI-01-0897 gb|AAP36136.1| Homo sapiens cholinergic receptor, muscarinic 1 [s...ynthetic construct] gb|AAX29286.1| cholinergic receptor muscarinic 1 [synthetic construct] gb|AAX29287.1| cholinergic receptor muscarinic 1 [synthetic construct] AAP36136.1 0.0 91% ...

  14. NCBI nr-aa BLAST: CBRC-OANA-01-0359 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-OANA-01-0359 gb|AAP36136.1| Homo sapiens cholinergic receptor, muscarinic 1 [s...ynthetic construct] gb|AAX29286.1| cholinergic receptor muscarinic 1 [synthetic construct] gb|AAX29287.1| cholinergic receptor muscarinic 1 [synthetic construct] AAP36136.1 5e-42 92% ...

  15. NCBI nr-aa BLAST: CBRC-EEUR-01-0488 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-EEUR-01-0488 gb|AAP36136.1| Homo sapiens cholinergic receptor, muscarinic 1 [s...ynthetic construct] gb|AAX29286.1| cholinergic receptor muscarinic 1 [synthetic construct] gb|AAX29287.1| cholinergic receptor muscarinic 1 [synthetic construct] AAP36136.1 7e-75 94% ...

  16. NCBI nr-aa BLAST: CBRC-CPOR-01-0167 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-CPOR-01-0167 gb|AAP36136.1| Homo sapiens cholinergic receptor, muscarinic 1 [s...ynthetic construct] gb|AAX29286.1| cholinergic receptor muscarinic 1 [synthetic construct] gb|AAX29287.1| cholinergic receptor muscarinic 1 [synthetic construct] AAP36136.1 9e-92 98% ...

  17. NCBI nr-aa BLAST: CBRC-TBEL-01-1343 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-TBEL-01-1343 gb|AAP36136.1| Homo sapiens cholinergic receptor, muscarinic 1 [s...ynthetic construct] gb|AAX29286.1| cholinergic receptor muscarinic 1 [synthetic construct] gb|AAX29287.1| cholinergic receptor muscarinic 1 [synthetic construct] AAP36136.1 0.0 98% ...

  18. NCBI nr-aa BLAST: CBRC-MDOM-05-0613 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MDOM-05-0613 gb|AAP36136.1| Homo sapiens cholinergic receptor, muscarinic 1 [s...ynthetic construct] gb|AAX29286.1| cholinergic receptor muscarinic 1 [synthetic construct] gb|AAX29287.1| cholinergic receptor muscarinic 1 [synthetic construct] AAP36136.1 0.0 89% ...

  19. NCBI nr-aa BLAST: CBRC-PVAM-01-1538 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-PVAM-01-1538 gb|AAP36136.1| Homo sapiens cholinergic receptor, muscarinic 1 [s...ynthetic construct] gb|AAX29286.1| cholinergic receptor muscarinic 1 [synthetic construct] gb|AAX29287.1| cholinergic receptor muscarinic 1 [synthetic construct] AAP36136.1 0.0 91% ...

  20. NCBI nr-aa BLAST: CBRC-SARA-01-0019 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-SARA-01-0019 gb|AAP36136.1| Homo sapiens cholinergic receptor, muscarinic 1 [s...ynthetic construct] gb|AAX29286.1| cholinergic receptor muscarinic 1 [synthetic construct] gb|AAX29287.1| cholinergic receptor muscarinic 1 [synthetic construct] AAP36136.1 0.0 96% ...

  1. NCBI nr-aa BLAST: CBRC-OCUN-01-1441 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-OCUN-01-1441 gb|AAP36136.1| Homo sapiens cholinergic receptor, muscarinic 1 [s...ynthetic construct] gb|AAX29286.1| cholinergic receptor muscarinic 1 [synthetic construct] gb|AAX29287.1| cholinergic receptor muscarinic 1 [synthetic construct] AAP36136.1 0.0 98% ...

  2. NCBI nr-aa BLAST: CBRC-MEUG-01-2700 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MEUG-01-2700 gb|AAP36136.1| Homo sapiens cholinergic receptor, muscarinic 1 [s...ynthetic construct] gb|AAX29286.1| cholinergic receptor muscarinic 1 [synthetic construct] gb|AAX29287.1| cholinergic receptor muscarinic 1 [synthetic construct] AAP36136.1 0.0 89% ...

  3. NCBI nr-aa BLAST: CBRC-CFAM-18-0237 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-CFAM-18-0237 gb|AAP36136.1| Homo sapiens cholinergic receptor, muscarinic 1 [s...ynthetic construct] gb|AAX29286.1| cholinergic receptor muscarinic 1 [synthetic construct] gb|AAX29287.1| cholinergic receptor muscarinic 1 [synthetic construct] AAP36136.1 0.0 98% ...

  4. Reference: 579 [Arabidopsis Phenome Database[Archive

    Lifescience Database Archive (English)

    Full Text Available amounts, and plants frequently make use of these nitrogen sources. The goal of this study was to identify tr...ant role of AAP1 for efficient use of nitrogen sources present in the rhizosphere. AAP1 transports uncharged

  5. Alchornea cordifolia extract protects wistar albino rats against ...

    African Journals Online (AJOL)

    Abstract. At the therapeutic doses, aetaminophen (N-acety1-p-aminophenol, paracetamol, AAP) is considered a safe drug, intake of toxic dosage could lead to liver disease. The hepatoxicity of AAP is mainly as a result of oxidative stress mediated by the metabolites of APP. The present work seeks to evaluate phytochemical ...

  6. NCBI nr-aa BLAST: CBRC-GGOR-01-1322 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-GGOR-01-1322 gb|AAP44475.1| transient receptor potential cation channel subfam...ily M member 4 splice variant C [Homo sapiens] gb|EAW52460.1| transient receptor potential cation channel, subfamily M, member 4, isoform CRA_a [Homo sapiens] AAP44475.1 3e-28 87% ...

  7. APPLICATION OF ASCORBIC ACID 2-PHOSPHATE AS A NEW ...

    African Journals Online (AJOL)

    An electrochemical assay of the enzyme alkaline phosphatase (ALP) using ascorbic acid 2-phosphate (AAP) as a new voltammetric substrate has been described in this paper. In the alkaline buffer solution the ALP enzymatic hydrolysis product of AAP was ascorbic acid (AA), which was an electro-active substance and had ...

  8. Unresolved Issues for Utilization of Atypical Antipsychotics in Schizophrenia: Antipsychotic Polypharmacy and Metabolic Syndrome

    Directory of Open Access Journals (Sweden)

    Sang Won Jeon

    2017-10-01

    Full Text Available Atypical antipsychotics (AAP are the prevailing form of schizophrenia treatment today due to their low side effects and superior efficacy. Nevertheless, some issues still need to be addressed. First, there are still a large number of patients with treatment-resistant schizophrenia (TRS, which has led to a growing trend to resort to AAP polypharmacy with few side effects. Most clinical treatment guidelines recommend clozapine monotherapy in TRS, but around one third of schizophrenic patients fail to respond to clozapine. For these patients, with clozapine-resistant schizophrenia AAP polypharmacy is a common strategy with a continually growing evidence base. Second, AAP generally have great risks for developing metabolic syndrome, such as weight gain, abnormality in glucose, and lipid metabolism. These metabolic side effects have become huge stumbling blocks in today’s schizophrenia treatment that aims to improve patients’ quality of life as well as symptoms. The exact reasons why this particular syndrome occurs in patients treated with AAP is as yet unclear though factors such as interaction of AAP with neurotransmitter receptors, genetic pholymorphisms, type of AAPs, length of AAP use, and life style of schizophrenic patients that may contribute to its development. The present article aimed to review the evidence underlying these key issues and provide the most reasonable interpretations to expand the overall scope of antipsychotics usage.

  9. Does a Structured Data Collection Form Improve The Accuracy of ...

    African Journals Online (AJOL)

    Objectives: To determine the extent to which use of a structured data collection form (SDCF) affected the diagnostic accuracy of AAP. Methodology: A before and after study carried out from October 2011 to March 2012 of patients aged 13 years and older presenting with AAP in the emergency department (ED) of Aga Khan ...

  10. Grr1p is required for transcriptional induction of amino acid permease genes and proper transcriptional regulation of genes in carbon metabolism of Saccharomyces cerevisiae

    DEFF Research Database (Denmark)

    Eckert-Boulet, Nadine; Regenberg, Birgitte; Nielsen, Jens

    2005-01-01

    The F-box protein Grr1p is involved in cell cycle regulation, glucose repression and transcriptional induction of the amino acid permease (AAP) gene AGP1. We investigated the role of Grr1p in amino acid-mediated induction of AAP genes by performing batch cultivations with a wild-type strain and a...

  11. Use of the adult attachment projective picture system in psychodynamic psychotherapy with a severely traumatized patient.

    Science.gov (United States)

    George, Carol; Buchheim, Anna

    2014-01-01

    The following case study is presented to facilitate an understanding of how the attachment information evident from Adult Attachment Projective Picture System (AAP) assessment can be integrated into a psychodynamic perspective in making therapeutic recommendations that integrate an attachment perspective. The Adult Attachment Projective Picture System (AAP) is a valid representational measure of internal representations of attachment based on the analysis of a set of free response picture stimuli designed to systematically activate the attachment system (George and West, 2012). The AAP provides a fruitful diagnostic tool for psychodynamic-oriented clinicians to identify attachment-based deficits and resources for an individual patient in therapy. This paper considers the use of the AAP with a traumatized patient in an inpatient setting and uses a case study to illustrate the components of the AAP that are particularly relevant to a psychodynamic conceptualization. The paper discusses also attachment-based recommendations for intervention.

  12. Do depressed patients on adjunctive atypical antipsychotics demonstrate a better quality of life compared to those on antidepressants only? A comparative cross-sectional study of a nationally representative sample of the US population.

    Science.gov (United States)

    Al-Ruthia, Yazed Sulaiman; Hong, Song Hee; Solomon, David

    2015-01-01

    The adjunctive use of some atypical antipsychotics (AAPs) has been popular for patients with treatment-resistant depression. However, little is known about the impact of these agents on patients' Health-related quality of life (HRQoL). The objective of this study is to examine the impact of the adjunctive AAPs use on HRQoL among users of antidepressants with self-reported depression. Patients with depression (ICD-9-CM: 296, 300, and 311), and to have used the given AAPs and/or antidepressants for at least a year, were identified in the Medical Expenditure Panel Survey of 2008-2011. The patients were classified into users of adjunctive AAPs (i.e., antidepressants plus AAPs) and users of antidepressants only. Adjusted multivariate linear regression analyses were conducted to examine the association between the utilization of AAPs and HRQoL measure.(c) A total of 3638 participants who met the inclusion criteria were identified (306 on AAPs vs. 3332 on antidepressants only). The study subjects were ≥18 years, predominately White (91.9%) and female (71%). The AAPs utilization was not associated with higher scores in the Physical Component Summary (PCS-12) of the Short Form Health Survey (SF-12v2) (β = 1.542, 95% CI = -0.0142 to 3.0977, P = 0.0521). Rather, it was negatively associated with the Mental Component Summary (MCS-12) scores of the SF-12v2 (β = -1.5537, 95% CI = -3.0247 to -0.0827, P = 0.0385). The utilization of AAPs was not associated with higher scores of HRQoL. The findings of this study should underscore the need to consider other treatment options as add-on therapy for depression before resorting to AAPs. Copyright © 2015 Elsevier Inc. All rights reserved.

  13. The EASE Quality Improvement Project: Improving Safe Sleep Practices in Ohio Children's Hospitals.

    Science.gov (United States)

    Macklin, Jamie R; Gittelman, Michael A; Denny, Sarah A; Southworth, Hayley; Arnold, Melissa Wervey

    2016-10-01

    Despite American Academy of Pediatrics (AAP) recommendations, many hospitalized infants are not observed in the appropriate safe sleep environment. Caregivers tend to model sleep patterns observed in a hospital setting. This project assessed the change in infant safe sleep practices within 6 children's hospitals after the implementation of a statewide quality improvement program. The AAP recruited hospitalists from each of the state's children's hospitals and asked them to form "safe sleep teams" within their institutions. Teams used a standardized data tool to collect information on the infant's age and sleep position/environment. They collected baseline data and then weekly for the duration of the 12-month project. Teams were required to implement at least 3 Plan-Do-Study-Act cycles. We calculated changes in safe sleep practices over time. Providers received Maintenance of Certification Part IV credit for participation. Teams collected 5343 audits at all participating sites. At baseline, only 279 (32.6%) of 856 of the sleeping infants were observed to follow AAP recommendations, compared with 110 (58.2%) of 189 (P sleep practices from 48.2% to 75.4% (P hospitals improved observed infant safe sleep behaviors and family report of safe sleep education. These behavior changes may lead to more appropriate safe sleep practices at home. Copyright © 2016 by the American Academy of Pediatrics.

  14. Monoclonal antibodies against accumulation-associated protein affect EPS biosynthesis and enhance bacterial accumulation of Staphylococcus epidermidis.

    Directory of Open Access Journals (Sweden)

    Jian Hu

    Full Text Available Because there is no effective antibiotic to eradicate Staphylococcus epidermidis biofilm infections that lead to the failure of medical device implantations, the development of anti-biofilm vaccines is necessary. Biofilm formation by S. epidermidis requires accumulation-associated protein (Aap that contains sequence repeats known as G5 domains, which are responsible for the Zn(2+-dependent dimerization of Aap to mediate intercellular adhesion. Antibodies against Aap have been reported to inhibit biofilm accumulation. In the present study, three monoclonal antibodies (MAbs against the Aap C-terminal single B-repeat construct followed by the 79-aa half repeat (AapBrpt1.5 were generated. MAb(18B6 inhibited biofilm formation by S. epidermidis RP62A to 60% of the maximum, while MAb(25C11 and MAb(20B9 enhanced biofilm accumulation. All three MAbs aggregated the planktonic bacteria to form visible cell clusters. Epitope mapping revealed that the epitope of MAb(18B6, which recognizes an identical area within AapBrpt constructs from S. epidermidis RP62A, was not shared by MAb(25C11 and MAb(20B9. Furthermore, all three MAbs were found to affect both Aap expression and extracellular polymeric substance (EPS, including extracellular DNA and PIA biosynthesis in S. epidermidis and enhance the cell accumulation. These findings contribute to a better understanding of staphylococcal biofilm formation and will help to develop epitope-peptide vaccines against staphylococcal infections.

  15. The hydrological context determines the beta-diversity of aerobic anoxygenic phototrophic bacteria in European Arctic seas but does not favor endemism

    Directory of Open Access Journals (Sweden)

    Anne-Catherine eLehours

    2015-07-01

    Full Text Available Despite an increasing number of studies over the last 15 years, aerobic anoxygenic photoheterotrophic (AAP bacteria remain a puzzling functional group in terms of physiology, metabolism, and ecology. To contribute to a better knowledge of their environmental distribution, the present study aims at analyzing their diversity and structure at the boundary between the Norwegian, Greenland, and Barents Seas. The polymorphism of a marker gene encoding a sub-unit of the photosynthetic apparatus (pufM gene was analyzed and attempted to be related to environmental parameters. The Atlantic or Arctic origin of water masses had a strong impact on the AAP bacterial community structure whose populations mostly belonged to the Alpha- and Gammaproteobacteria. A majority (> 60 % of pufM sequences were affiliated to the Gammaproteobacteria reasserting that this class often represents the major component of the AAP bacterial community in oceanic regions. Two alphaproteobacterial groups dominate locally suggesting that they can constitute key players in this marine system transiently. We found that temperature is a major determinant of alpha diversity of AAP bacteria in this marine biome with specific clades emerging locally according to the partitioning of water masses. Whereas we expected specific AAP bacterial populations in this peculiar and newly explored ecosystem, most pufM sequences were highly related to sequences retrieved elsewhere. This observation highlights that the studied area does not favor AAP bacteria endemism but also opens new questions about the truthfulness of biogeographical patterns and on the extent of AAP bacterial diversity.

  16. Hpyerglycemic and anti-diabetic nephritis activities of polysaccharides separated from Auricularia auricular in diet-streptozotocin-induced diabetic rats.

    Science.gov (United States)

    Hu, Xinyu; Liu, Chungang; Wang, Xue; Jia, Dongxu; Lu, Wenqian; Sun, Xiaoqi; Liu, Yang; Yuan, Lijia

    2017-01-01

    Due to substantial morbidity and complications including nephropathy, a search for alternative treatment of diabetes mellitus is urgently required. The present study aimed to investigate the hypoglycemic and anti-diabetic nephropathy activities of polysaccharides separated from Auricularia auricular (AAP). Diet streptozotocin (STZ)-induced diabetic Sprague-Dawley rats were orally treated with metformin (100 mg/kg; positive control) and AAP (100 and 400 mg/kg) for four weeks, and parameters in the serum and liver associated with blood glucose, free radicals and nephropathy were determined. Similar to metformin, AAP treatment strongly reduced blood glucose levels by promoting glucose metabolism. The anti-oxidative activity of AAP, which was indicated by the modulation of superoxide dismutase, glutathione peroxidase, reactive oxygen species and methane dicarboxylic aldehyde levels in serum, was observed in diabetic rats. Furthermore, the regulatory effects of AAP on blood urea nitrogen, creatinine, uric protein and inflammatory-related factors revealed its protection against diabetic nephropathy. The present data suggests that AAP-mediated anti-diabetic and anti-nephritic effects are partially associated with their modulations on the anti-oxidative system and nuclear factor kappa B-related signaling pathway. In conclusion, AAP has potential to be a novel source of treatments for diabetes.

  17. Evaluation of Prevalence, Homology and Immunogenicity of Dispersin among Enteroaggregative Escherichia coli Isolates from Iran.

    Science.gov (United States)

    Asadi Karam, Mohammad Reza; Rezaei, Ali Akbar; Siadat, Seyed Davar; Habibi, Mehri; Bouzari, Saeid

    2017-01-01

    Diarrhea, caused by enteroaggregative Escherichia coli (EAEC), is an important infection leading toillness and death. Numerous virulent factors have been described in EAEC. However, their prevalence was highly variable among EAECs of distinct geographic locations. Studies have shown that dispersin (antiaggregation protein, aap) is one of the important and abundant virulent factors in EAEC. In this study, we aimed to determine the presence, conservation, and immunogenicity of aap gene in EAEC isolated from Iranian patients. PCR amplification of aap gene in the EAEC isolates was performed, and the aap gene was cloned in pBAD-gIIIA vector. The sequence of aap gene was analyzed using the ExPASy and BLAST tools. The expression of aap gene was performed in E. coli Top10, and expression confirmation was carried out by SDS-PAGE and Western-blot techniques. Rabbits were immunized with purified dispersin protein emulsified with Freund's adjuvant. Sera were collected and examined for antibody response. Finally, in vitro efficacy of dispersin and anti-dispersin was evaluated. The results of PCR showed the presence of aap gene in all of the EAEC isolates with significant homology. Finally, the significant difference between the levels of IgG response in dispersin-injected rabbits and control group was observed. Our results were in accordance with other studies that reported the presence of dispersin in the EAEC isolates with high conservation and immunogenicity. Hence, dispersin could be a promising candidate for any probable prevention against EAEC infections.

  18. Does the use of atypical antipsychotics as adjunctive therapy in depression result in cost savings? Comparing healthcare costs and utilization between second-line treatment options.

    Science.gov (United States)

    Hassan, Amany K; Farmer, Kevin C; Brahm, Nancy C; Keast, Shellie; Nesser, Nancy; Neas, Barbara R

    2016-12-01

    Several atypical antipsychotics (AAPs) are used as second-line agents for treatment resistant depression. AAPs can be expensive compared to other treatment options and can cause several side effects. To estimate healthcare costs and utilization of AAPs compared to other second-line agents. Observational study using Medicaid claims data (2006-2011). Subjects were depression-diagnosed adult members with at least two prescriptions of antidepressant medications followed by a second-line agent. Gamma generalized linear models (GLM) produced estimates of the difference in mean expenditures among treatment groups after adjusting for individual baseline characteristics using propensity scores. Negative binomial models produced estimates of the difference in number of hospitalizations and emergency department (ED) visits. A total of 3910 members received second-line treatment. Treatment groups were AAPs (n = 2211), augmentation agents other than AAPs (n = 1008), and antidepressant switching (n = 691). AAPs resulted in higher mean adjusted pharmacy costs and higher mean adjusted total mental health-related costs. Mean adjusted total healthcare costs and number of inpatient and ED visits were not different among treatments. The results show no evidence that AAPs used as second-line treatment for depression results in overall cost savings or lower inpatient and ED visits compared to other treatment strategies.

  19. X-ray crystallographic characterization of the Co(II)-substituted Tris-bound form of the aminopeptidase from Aeromonas proteolytica.

    Science.gov (United States)

    Munih, Petra; Moulin, Aaron; Stamper, Carin C; Bennett, Brian; Ringe, Dagmar; Petsko, Gregory A; Holz, Richard C

    2007-08-01

    The X-ray crystal structure of the Co(II)-loaded form of the aminopeptidase from Aeromonas proteolytica ([CoCo(AAP)]) was solved to 2.2A resolution. [CoCo(AAP)] folds into an alpha/beta globular domain with a twisted beta-sheet hydrophobic core sandwiched between alpha-helices, identical to [ZnZn(AAP)]. Co(II) binding to AAP does not introduce any major conformational changes to the overall protein structure and the amino acid residues ligated to the dicobalt(II) cluster in [CoCo(AAP)] are the same as those in the native Zn(II)-loaded structure with only minor perturbations in bond lengths. The Co(II)-Co(II) distance is 3.3A. Tris(hydroxymethyl)aminomethane (Tris) coordinates to the dinuclear Co(II) active site of AAP with one of the Tris hydroxyl oxygen atoms (O4) forming a single oxygen atom bridge between the two Co(II) ions. This is the only Tris atom coordinated to the metals with Co1-O and Co2-O bonds distances of 2.2 and 1.9A, respectively. Each of the Co(II) ions resides in a distorted trigonal bipyramidal geometry. This important structure bridges the gap between previous structural and spectroscopic studies performed on AAP and is discussed in this context.

  20. The metalloprotease SepA governs processing of accumulation-associated protein and shapes intercellular adhesive surface properties in Staphylococcus epidermidis.

    Science.gov (United States)

    Paharik, Alexandra E; Kotasinska, Marta; Both, Anna; Hoang, Tra-My N; Büttner, Henning; Roy, Paroma; Fey, Paul D; Horswill, Alexander R; Rohde, Holger

    2017-03-01

    The otherwise harmless skin inhabitant Staphylococcus epidermidis is a major cause of healthcare-associated medical device infections. The species' selective pathogenic potential depends on its production of surface adherent biofilms. The Cell wall-anchored protein Aap promotes biofilm formation in S. epidermidis, independently from the polysaccharide intercellular adhesin PIA. Aap requires proteolytic cleavage to act as an intercellular adhesin. Whether and which staphylococcal proteases account for Aap processing is yet unknown. Here, evidence is provided that in PIA-negative S. epidermidis 1457Δica, the metalloprotease SepA is required for Aap-dependent S. epidermidis biofilm formation in static and dynamic biofilm models. qRT-PCR and protease activity assays demonstrated that under standard growth conditions, sepA is repressed by the global regulator SarA. Inactivation of sarA increased SepA production, and in turn augmented biofilm formation. Genetic and biochemical analyses demonstrated that SepA-related induction of biofilm accumulation resulted from enhanced Aap processing. Studies using recombinant proteins demonstrated that SepA is able to cleave the A domain of Aap at residue 335 and between the A and B domains at residue 601. This study identifies the mechanism behind Aap-mediated biofilm maturation, and also demonstrates a novel role for a secreted staphylococcal protease as a requirement for the development of a biofilm. © 2016 John Wiley & Sons Ltd.

  1. A weight-independent association between atypical antipsychotic medications and obstructive sleep apnea.

    Science.gov (United States)

    Khazaie, Habibolah; Sharafkhaneh, Amir; Khazaie, Sepideh; Ghadami, Mohammad Rasoul

    2017-07-13

    With increasing use of atypical antipsychotic (AAP) agents, the concern has been raised about the association between AAP agents and medical complications. Obstructive sleep apnea (OSA) is a common breathing disorder that adversely affects health and quality of life. Because the major risk factors for OSA are weight gain and obesity by altering the upper airway anatomy, an association between AAP and development of OSA is predictable. However, we hypothesized that AAP may promote OSA not only by weight gain but also because of its potential effects on upper airway muscle function. In the present study, we evaluated the possible association between AAP use and the severity of OSA. A sample of patients using AAP for treatment of paradoxical insomnia was evaluated before and at least 8 weeks after AAP use. Patients were divided based on type of AAP use to olanzapine, risperidone, and quetiapine groups. Patients used olanzapine (5-10 mg), risperidone (2-4 mg), or quetiapine (100-200 mg) 2 h before bedtime. Before and after treatment, respiratory variables were recorded using polysomnography. BMI, neck circumference (NC), and waist circumference (WC) were measured before and after treatment period. There was no significant difference between pre- and post-treatment apnea index (0.2 ± 0.6 vs. 2.6 ± 4.3; p = 0.094) in olanzapine group. However, significant differences in hypopnea index (5.1 ± 5 vs. 30 ± 10.8; p weight gain as a main risk factor of OSA, our finding demonstrated a weight-independent association between AAP medications and worsening respiration during sleep.

  2. Patterns in Abundance, Cell Size and Pigment Content of Aerobic Anoxygenic Phototrophic Bacteria along Environmental Gradients in Northern Lakes.

    Directory of Open Access Journals (Sweden)

    Lisa Fauteux

    Full Text Available There is now evidence that aerobic anoxygenic phototrophic (AAP bacteria are widespread across aquatic systems, yet the factors that determine their abundance and activity are still not well understood, particularly in freshwaters. Here we describe the patterns in AAP abundance, cell size and pigment content across wide environmental gradients in 43 temperate and boreal lakes of Québec. AAP bacterial abundance varied from 1.51 to 5.49 x 105 cells mL-1, representing <1 to 37% of total bacterial abundance. AAP bacteria were present year-round, including the ice-cover period, but their abundance relative to total bacterial abundance was significantly lower in winter than in summer (2.6% and 7.7%, respectively. AAP bacterial cells were on average two-fold larger than the average bacterial cell size, thus AAP cells made a greater relative contribution to biomass than to abundance. Bacteriochlorophyll a (BChla concentration varied widely across lakes, and was not related to AAP bacterial abundance, suggesting a large intrinsic variability in the cellular pigment content. Absolute and relative AAP bacterial abundance increased with dissolved organic carbon (DOC, whereas cell-specific BChla content was negatively related to chlorophyll a (Chla. As a result, both the contribution of AAP bacteria to total prokaryotic abundance, and the cell-specific BChla pigment content were positively correlated with the DOC:Chla ratio, both peaking in highly colored, low-chlorophyll lakes. Our results suggest that photoheterotrophy might represent a significant ecological advantage in highly colored, low-chlorophyll lakes, where DOC pool is chemically and structurally more complex.

  3. Improving Family Communications

    Science.gov (United States)

    ... Spread the Word Shop AAP Find a Pediatrician Family Life Medical Home Family Dynamics Adoption & Foster Care ... Listen Español Text Size Email Print Share Improving Family Communications Page Content Article Body How can I ...

  4. One Family's Struggles with Pertussis (Whooping Cough)

    Medline Plus

    Full Text Available ... Tos Ferina AAP CME ask your doctor brochure family stories faq meet dr. gary freed meet keri ... media video/audio pneumonia tb overview links & resources families advocacy about civil rights kids' rights sample school ...

  5. One Family's Struggles with HPV (Human Papillomavirus)

    Medline Plus

    Full Text Available ... Tos Ferina AAP CME ask your doctor brochure family stories faq meet dr. gary freed meet keri ... media video/audio pneumonia tb overview links & resources families advocacy about civil rights kids' rights sample school ...

  6. One Family's Struggle with Chickenpox

    Medline Plus

    Full Text Available ... Tos Ferina AAP CME ask your doctor brochure family stories faq meet dr. gary freed meet keri ... media video/audio pneumonia tb overview links & resources families advocacy about civil rights kids' rights sample school ...

  7. Normal Functioning Family

    Science.gov (United States)

    ... Spread the Word Shop AAP Find a Pediatrician Family Life Medical Home Family Dynamics Adoption & Foster Care ... Español Text Size Email Print Share Normal Functioning Family Page Content Article Body Is there any way ...

  8. Roles within the Family

    Science.gov (United States)

    ... Spread the Word Shop AAP Find a Pediatrician Family Life Medical Home Family Dynamics Adoption & Foster Care ... Text Size Email Print Share Roles Within the Family Page Content Article Body Families are not democracies. ...

  9. One Family's Struggles with Rotavirus

    Medline Plus

    Full Text Available ... Tos Ferina AAP CME ask your doctor brochure family stories faq meet dr. gary freed meet keri ... media video/audio pneumonia tb overview links & resources families advocacy about civil rights kids' rights sample school ...

  10. One Family's Struggles with Hepatitis B

    Medline Plus

    Full Text Available ... Tos Ferina AAP CME ask your doctor brochure family stories faq meet dr. gary freed meet keri ... media video/audio pneumonia tb overview links & resources families advocacy about civil rights kids' rights sample school ...

  11. Myth of the Perfect Family

    Science.gov (United States)

    ... Spread the Word Shop AAP Find a Pediatrician Family Life Medical Home Family Dynamics Adoption & Foster Care ... Español Text Size Email Print Share The "Perfect" Family Page Content Article Body Is there such a ...

  12. Rapid determination of total phenols in seawater by 4-aminoantipyrine colorimetry

    Digital Repository Service at National Institute of Oceanography (India)

    Kadam, A.N.; Bhangale, V.P.

    A rapid and efficient 4-aminoantipyrine (4-AAP) colorimetric method without any cleanup step to determine total phenols in seawater is described. Efficiency of the method for seawater using external addition of phenol concentrations with working...

  13. Chemical properties of a polysaccharide purified from solid-state fermentation of Auricularia auricular and its biological activity as a hypolipidemic agent.

    Science.gov (United States)

    Zeng, Feng; Zhao, Chao; Pang, Jie; Lin, Zhanxi; Huang, Yifan; Liu, Bin

    2013-09-01

    A water-soluble crude polysaccharide was extracted by hot water from Auricularia auricular mycelium grown under solid-state fermentation (SSF). The crude polysaccharide was purified by DEAE Sephadex A-50 and Sephadex G-200 chromatography. Fourier transform infrared spectroscopy and nuclear magnetic resonance ((1) H NMR) spectroscopy were used to investigate the structure of the purified A. auricular polysaccharide (AAP-I) and revealed that it is α-glycosidically linked. After 14 and 28 days of AAP-I orally administered, the AAP-I significantly decreased the levels of total cholesterol, triglyceride, and low-density lipoprotein cholesterol in mice in which hyperlipidemia had been induced by a high fat diet (P < 0.05). The results revealed that AAP-I from SSF of A. auricular mycelium possesses potent hypolipidemic properties. The polysaccharide may be useful as a functional food additive and a hypolipidemic agent. © 2013 Institute of Food Technologists®

  14. Baltimore Eesti Selts - 75 / Vilve Ladon ; fotod: Fred Ise

    Index Scriptorium Estoniae

    Ladon, Vilve

    2010-01-01

    Baltimore Eesti Majas tähistati 2. okt. 2010 Baltimore Eesti Seltsi aastapäeva. Eesti suursaatkonna esimene sekretär poliitilistes küsimustes Aap Neljas edastas president Toomas Hendrik Ilvese tervituse

  15. Toddler Bedtime Trouble: Tips for Parents

    Science.gov (United States)

    ... 18-21yrs. Healthy Living Healthy Living Healthy Living Nutrition Fitness Sports Oral Health Emotional Wellness Growing Healthy Sleep Safety & ... Word Shop AAP Find a Pediatrician Healthy Living Nutrition ... Fitness Sports Oral Health Emotional Wellness Building Resilience Sleep Growing ...

  16. Poison Prevention

    Science.gov (United States)

    ... the Word Shop AAP Find a Pediatrician Safety & Prevention Immunizations All Around At Home At Play On ... Listen Español Text Size Email Print Share Poison Prevention Page Content Article Body Post the Poison Help ...

  17. 40 CFR Appendix A to Part 419 - Processes Included in the Determination of BAT Effluent Limitations for Total Chromium...

    Science.gov (United States)

    2010-07-01

    ..., and Phenolic Compounds (4AAP) Crude Processes 1. Atmospheric Crude Distillation 2. Crude Desalting 3. Vacuum Crude Distillation Cracking and Coking Processes 4. Visbreaking 5. Thermal Cracking 6. Fluid...

  18. Asthma Triggers and What to Do about Them

    Science.gov (United States)

    ... 21/2015 Source AAP Section on Allergy and Immunology (Copyright © 2003) The information contained on this Web ... information: verify here. © Copyright 2018 American Academy of Pediatrics. All rights reserved.

  19. School Avoidance: Tips for Concerned Parents

    Science.gov (United States)

    ... Fears and Anxieties How to Ease Your Child's Separation Anxiety What to Know about Child Abuse What Parents Can Do to Support Friendships Understanding the Behavioral and Emotional Consequences of Child Abuse (AAP Policy Statement) AttendanceWorks. ...

  20. Signs of Overload

    Science.gov (United States)

    ... Spread the Word Shop AAP Find a Pediatrician Healthy Living Nutrition Fitness Sports Oral Health Emotional Wellness Building Resilience Sleep Growing Healthy Healthy Children > Healthy Living > Emotional Wellness > Signs of ...

  1. Effect effects of Auricularia auricula polysaccharides on exhaustive ...

    African Journals Online (AJOL)

    MDA), 8-hydroxydeoxyguanosine (8-OHdG), superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) were determined. Results: Exhaustive swimming times were significantly prolonged in all AAPs-treated animals as ...

  2. Ecology of aerobic anoxygenic phototrophs in aquatic environments.

    Science.gov (United States)

    Koblížek, Michal

    2015-11-01

    Recognition of the environmental role of photoheterotrophic bacteria has been one of the main themes of aquatic microbiology over the last 15 years. Aside from cyanobacteria and proteorhodopsin-containing bacteria, aerobic anoxygenic phototrophic (AAP) bacteria are the third most numerous group of phototrophic prokaryotes in the ocean. This functional group represents a diverse assembly of species which taxonomically belong to various subgroups of Alpha-, Beta- and Gammaproteobacteria. AAP bacteria are facultative photoheterotrophs which use bacteriochlorophyll-containing reaction centers to harvest light energy. The light-derived energy increases their bacterial growth efficiency, which provides a competitive advantage over heterotrophic species. Thanks to their enzymatic machinery AAP bacteria are active, rapidly growing organisms which contribute significantly to the recycling of organic matter. This chapter summarizes the current knowledge of the ecology of AAP bacteria in aquatic environments, implying their specific role in the microbial loop. © FEMS 2015. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  3. Teasing and Bullying of Obese and Overweight Children: How Parents Can Help

    Science.gov (United States)

    ... in Children: How Parents Can Help Page Content Children with obesity have to deal with many challenges beyond pressures ... Additional Information Obesity Prevention: AAP Policy Explained Childhood Obesity: Common ... & Address Bullying Article Body Last Updated 11/ ...

  4. Questions and Answers about Sex (For Parents)

    Science.gov (United States)

    ... Pediatrics (AAP), and shouldn't bring scolding or punishment. So, what should you do when your toddler ... when a doctor or nurse is performing a physical exam. Kids should know that if anyone ever ...

  5. Find a Periodontist

    Science.gov (United States)

    ... in Perio CAP Editors AAP Clinical and Scientific Papers Periospectives Magazine Glossary of Periodontal Terms Periodontal Literature ... MEXICO MOROCCO NETHERLANDS NEW ZEALAND NICARAGUA NORWAY PAKISTAN PANAMA PERU PHILIPPINES POLAND PORTUGAL SAUDI ARABIA SERBIA SINGAPORE ...

  6. American Academy of Pediatrics

    Science.gov (United States)

    ... AAP Urges Elected Leaders to Protect Communities from Gun Violence Gun violence is in everyone's hometown. This affects all ... Infectious Diseases Associated With Organized Sports and Outbreak Control Infection Prevention and Control in Pediatric Ambulatory Settings ...

  7. One Family's Struggles with Hepatitis B

    Medline Plus

    Full Text Available ... Sounds of Pertussis Acalla los Sonidos de la Tos Ferina AAP CME ask your doctor brochure family ... ask the advice nurse ask the experts back-to-school health clinical trials disclosing to kids estate ...

  8. Asparaginase-associated pancreatitis is not predicted by hypertriglyceridemia or pancreatic enzyme levels in children with acute lymphoblastic leukemia

    DEFF Research Database (Denmark)

    Raja, Raheel Altaf; Schmiegelow, Kjeld; Sørensen, Ditte Nørbo

    2017-01-01

    Background: l-Asparaginase is an important drug for treatment of childhood acute lymphoblastic leukemia (ALL), but is associated with serious toxicities, including pancreatitis and hypertriglyceridemia (HTG). Asparaginase-associated pancreatitis (AAP) is a common reason for stopping asparaginase...

  9. Gender Identity and Gender Confusion in Children

    Science.gov (United States)

    ... and Their Parents Office-Based Care for Lesbian, Gay, Bisexual, Transgender, and Questioning Youth (AAP Policy Statement) Gender Spectrum Family Acceptance Project (familyproject.sfsu.edu) Lesbian, Gay, Bisexual and ...

  10. Evaluation of Some Anionic Exchange Resins as Potential Tablet ...

    African Journals Online (AJOL)

    . The thickness and ... synthesis of the resins via polymerization [13]. In previous studies, these resins were pharmaceutically ..... classes of superdisintegrants in promoting aspirin tablet disintegration and dissolution. AAPS. PharmSciTech ...

  11. The Automated Assessment of Postural Stability: Balance Detection Algorithm.

    Science.gov (United States)

    Napoli, Alessandro; Glass, Stephen M; Tucker, Carole; Obeid, Iyad

    2017-12-01

    Impaired balance is a common indicator of mild traumatic brain injury, concussion and musculoskeletal injury. Given the clinical relevance of such injuries, especially in military settings, it is paramount to develop more accurate and reliable on-field evaluation tools. This work presents the design and implementation of the automated assessment of postural stability (AAPS) system, for on-field evaluations following concussion. The AAPS is a computer system, based on inexpensive off-the-shelf components and custom software, that aims to automatically and reliably evaluate balance deficits, by replicating a known on-field clinical test, namely, the Balance Error Scoring System (BESS). The AAPS main innovation is its balance error detection algorithm that has been designed to acquire data from a Microsoft Kinect® sensor and convert them into clinically-relevant BESS scores, using the same detection criteria defined by the original BESS test. In order to assess the AAPS balance evaluation capability, a total of 15 healthy subjects (7 male, 8 female) were required to perform the BESS test, while simultaneously being tracked by a Kinect 2.0 sensor and a professional-grade motion capture system (Qualisys AB, Gothenburg, Sweden). High definition videos with BESS trials were scored off-line by three experienced observers for reference scores. AAPS performance was assessed by comparing the AAPS automated scores to those derived by three experienced observers. Our results show that the AAPS error detection algorithm presented here can accurately and precisely detect balance deficits with performance levels that are comparable to those of experienced medical personnel. Specifically, agreement levels between the AAPS algorithm and the human average BESS scores ranging between 87.9% (single-leg on foam) and 99.8% (double-leg on firm ground) were detected. Moreover, statistically significant differences in balance scores were not detected by an ANOVA test with alpha equal to 0

  12. NCBI nr-aa BLAST: CBRC-MEUG-01-1882 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MEUG-01-1882 gb|AAP88735.1| MCM2 minichromosome maintenance deficient 2, mitot...in (S. cerevisiae) [synthetic construct] gb|AAX29736.1| MCM2 minichromosome maintenance deficient 2 [synthet...ic construct] gb|AAX29737.1| MCM2 minichromosome maintenance deficient 2 [synthetic construct] AAP88735.1 0.0 95% ...

  13. 40 CFR 419.53 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

    Science.gov (United States)

    2010-07-01

    ... feedstock) Phenolic compounds (4AAP): Crude 0.037 0.009 Cracking and coking 0.419 0.102 Asphalt 0.226 0.055... Reforming and alkylation 0.0196 0.0088 English units (pounds per 1,000 bbl of feedstock) Phenolic compounds... flow) Phenolic compounds (4AAP) 0.35 0.17 Total chromium 0.60 0.21 Hexavalent chromium 0.062 0.028 COD...

  14. 40 CFR 419.33 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

    Science.gov (United States)

    2010-07-01

    ... days shall not exceed Metric units (kilograms per 1,000 cubic meters of feedstock) Phenolic compounds... alkylation 0.0196 0.0088 English units (pounds per 1,000 bbl of feedstock) Phenolic compounds (4AAP): Crude 0... flow) Phenolic compounds (4AAP) 0.35 0.17 Total chromium 0.60 0.21 Hexavalent chromium 0.062 0.028 COD...

  15. 40 CFR 419.23 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

    Science.gov (United States)

    2010-07-01

    ...) Phenolic compounds (4AAP): Crude 0.037 0.009 Cracking and coking 0.419 0.102 Asphalt 0.226 0.055 Lube 1.055... Reforming and alkylation 0.0196 0.0088 English units (pounds per 1,000 bbl of feedstock) Phenolic compounds... flow) Phenolic compounds (4AAP) 0.35 0.17 Total chromium 0.60 0.21 Hexavalent chromium 0.062 0.028 COD...

  16. Atypical Antipsychotics and the Risk of Hyperlipidemia: A Sequence Symmetry Analysis.

    Science.gov (United States)

    Takeuchi, Yoshinori; Kajiyama, Kazuhiro; Ishiguro, Chieko; Uyama, Yoshiaki

    2015-07-01

    Although hyperlipidemia is a well known adverse event of atypical antipsychotic (AAP) medication, there are few studies that have quantitatively compared the risks of various AAPs. Our aim was to comparatively evaluate the risk of hyperlipidemia associated with the use of AAPs approved in Japan through a consecutive epidemiological study. We conducted a sequence symmetry analysis (SSA) using health insurance claims data to analyze the following nine AAPs approved for use in Japan: risperidone, paliperidone, perospirone hydrochloride hydrate, blonanserin, clozapine, olanzapine, quetiapine fumarate, aripiprazole, and zotepine. Exposed cases were identified from drug dispensing records as those who had been administered both AAPs and antihyperlipidemic drugs. The adjusted sequence ratio (ASR) and 95 % confidence interval (CI) for each individual AAP and for all AAPs were calculated while controlling for time trends in dispensing patterns. Olanzapine was significantly associated with increased hyperlipidemia occurrence (ASR 1.56; 95 % CI 1.25-1.95). The ASRs obtained for risperidone (1.01; 95 % CI 0.80-1.27), perospirone hydrochloride hydrate (0.93; 95 % CI 0.63-1.39), blonanserin (0.83; 95 % CI 0.52-1.33), quetiapine fumarate (0.93; 95 % CI 0.73-1.18), and aripiprazole (1.02; 95 % CI 0.82-1.26) were approximately 1.0. Unstable estimates (wide CIs) were obtained for paliperidone and zotepine due to the small sample sizes. Among the AAPs used in Japan, only olanzapine was found to have an elevated risk of hyperlipidemia. In contrast, risperidone, perospirone hydrochloride hydrate, blonanserin, quetiapine fumarate, and aripiprazole had relatively low risks.

  17. Comparative efficacy and acceptability of seven augmentation ...

    African Journals Online (AJOL)

    The results revealed that T3 was more efficacious than lithium, TCAs, AAPs, AEDs, buspirone and CBT with odds ratios (ORs) of 1.58, 1.56, 1.51, 1.47, 1.77 and 1.25, respectively. ORs favoured CBT compared with lithium, TCAs, AAPs, AEDs and buspirone. Buspirone was the least efficacious of all the other augmentation ...

  18. Isolation of a polysaccharide with anticancer activity from Auricularia polytricha using high-speed countercurrent chromatography with an aqueous two-phase system.

    Science.gov (United States)

    Song, Guanglei; Du, Qizhen

    2010-09-17

    Polysaccharides from a crude extract of Auricularia polytricha were separated by high-speed countercurrent chromatography (HSCCC). The separation was performed with an aqueous two-phase system of PEG1000-K2HPO4-KH2PO4-H2O (0.5:1.25:1.25:7.0, w/w). The crude sample (2.0 g) was successfully separated into three polysaccharide components of AAPS-1 (192 mg), AAPS-2 (137 mg), and AAPS-3 (98 mg) with molecular weights of 162, 259, and 483 kDa, respectively. These compounds were tested for growth inhibition of transplanted S180 sarcoma in mice. AAPS-2 had an inhibition rate of 40.4%. The structure of AAPS-2 was elucidated from partial hydrolysis, periodate oxidation, acetylation, methylation analysis, and NMR spectroscopy (1H, 13C). These results showed AAPS-2 is a polysaccharide with a backbone of (1-->3)-linked-beta-d-glucopyranosyl and (1-->3, 6)-linked-beta-D-glucopyranosyl residues in a 2:1 ratio, and has one terminal (1-->)-beta-D-glucopyranosyl at the O-6 position of (1-->3, 6)-linked-beta-D-glucopyranosyl of the main chain. 2010 Elsevier B.V. All rights reserved.

  19. Acute ethanol and taurine intake affect absolute alpha power in frontal cortex before and after exercise.

    Science.gov (United States)

    Paulucio, Dailson; da Costa, Bruno M; Santos, Caleb G; Velasques, Bruna; Ribeiro, Pedro; Gongora, Mariana; Cagy, Mauricio; Alvarenga, Renato L; Pompeu, Fernando A M S

    2017-09-14

    Taurine and alcohol has been popularly ingested through energy drinks. Reports from both compounds shows they are active on nervous system but little is known about the acute effect of these substances on the frontal cortex in an exercise approach. The aim of this study was to determine the effects of 0,6mldL -1 of ethanol (ET), 6g of taurine (TA), and taurine with ethanol (TA+ET) intake on absolute alpha power (AAP) in the frontal region, before and after exercise. Nine participants were recruited, five women (22±3years) and four men (26±5years), for a counterbalanced experimental design. For each treatment, the tests were performed considering three moments: "baseline", "peak" and "post-exercise". In the placebo treatment (PL), the frontal areas showed AAP decrease at the post-exercise. However, in the TA, AAP decreased at peak and increased at post-exercise. In the ET treatment, AAP increased at the peak moment for the left frontal electrodes. In the TA+ET treatment, an AAP increase was observed at peak, and it continued after exercise ended. These substances were able to produce electrocortical activity changes in the frontal regions after a short duration and low intensity exercise. Left and right regions showed different AAP dynamics during peak and post-exercise moments when treatments were compared. Copyright © 2017 Elsevier B.V. All rights reserved.

  20. Effect of augmented atypical antipsychotics on weight change in patients with major depressive disorder in a naturalistic setting.

    Science.gov (United States)

    Seo, Ho-Jun; Jung, Young-Eun; Woo, Young Sup; Jun, Tae-Youn; Chae, Jeong-Ho; Bahk, Won-Myong

    2009-03-01

    The extent of weight changes in depressed patients who use atypical antipsychotics (AAP) as augmentation could not be easily predicted due to weight related symptoms of depression and the interaction with antidepressants which have weight reducing effects. Patients were treated with either antidepressants augmented with AAP for more than 2 weeks (AAP group, n = 100) or only with antidepressants (non-AAP group, n = 172) during the admission between 2002 and 2006, and the differences in weight were analyzed. Mean weight gains of AAP group were significantly higher than those of non-AAP group (2.98 +/- 1.87 kg vs. 1.70 +/- 1.85 kg, p = 0.001). When stratified by antidepressants, the significant difference between the two groups was shown among the subjects who had taken serotonin reuptake inhibitors (SSRIs), but not mirtazapine and venlafaxine (3.42 +/- 2.01 kg vs. 1.48 +/- 1.79 kg, p depression could severely aggravate preexisting weight-related problems of antidepressants use and the possibility that the combined use with specific antidepressants could have a unique effect on weight by drug-drug interactions.

  1. The haloperoxidase of the agaric fungus Agrocybe aegerita hydroxylates toluene and naphthalene.

    Science.gov (United States)

    Ullrich, René; Hofrichter, Martin

    2005-11-07

    The mushroom Agrocybe aegerita secretes a peroxidase (AaP) that catalyzes halogenations and hydroxylations. Phenol was brominated to 2- and 4-bromophenol (ratio 1:4) and chlorinated to a lesser extent to 2-chlorophenol. The purified enzyme was found to oxidize toluene via benzyl alcohol and benzaldehyde into benzoic acid. A second fraction of toluene was hydroxylated to give p-cresol as well as o-cresol and methyl-p-benzoquinone. The UV-Vis absorption spectrum of purified AaP showed high similarity to a resting state cytochrome P450 with the Soret band at 420 nm and additional maxima at 278, 358, 541 and 571 nm; the AaP CO-complex had a distinct absorption maximum at 445 nm that is characteristic for heme-thiolate proteins. AaP regioselectively hydroxylated naphthalene to 1-naphthol and traces of 2-naphthol (ratio 36:1). H2O2 was necessarily required for AaP function and hence the hydroxylations catalyzed by AaP can be designated as peroxygenation and the enzyme as an extracellular peroxygenase.

  2. Description and Results: Antenna Measurement Facility Comparisons [Measurements Corner

    DEFF Research Database (Denmark)

    Alberica Saporetti, Maria; Foged, Lars; Sierra Castañer, Manuel

    2017-01-01

    the management of the European Association on Antennas and Propagation (EurAAP), supported by the European Cooperation in Science and Technology (COST) in the programs Antenna Systems and Sensors for Information Society Technologies (ASSIST) IC0603 and Versatile, Integrated, and Signal-Aware Technologies...... for Antennas (VISTA) IC1102, including still ongoing campaigns [3]-[5]. Results of these activities have led to improvements in antenna measurement procedures and protocols in facilities and standards [6], [7]. Due to the direct benefits available to the participants, the activities have been very successful...

  3. Trends in the use of standardized tools for developmental screening in early childhood: 2002-2009.

    Science.gov (United States)

    Radecki, Linda; Sand-Loud, Nina; O'Connor, Karen G; Sharp, Sanford; Olson, Lynn M

    2011-07-01

    Early identification of developmental delays is essential for optimal early intervention. An American Academy of Pediatrics (AAP) 2002 Periodic Survey of Fellows found education programs promoted screening implementation. In 2006, the AAP issued a revised policy statement with a detailed algorithm. Since the 2002 Periodic Survey, no national surveys have examined the effectiveness of policy, programmatic, and educational enhancements. The goal of this study was to compare pediatricians' use of standardized screening tools from 2002 to 2009. A national, random sample of nonretired US AAP members were mailed Periodic Surveys (2002: N=1617, response rate: 55%; 2009: N=1620, response rate: 57%). χ(2) analyses were used to examine responses across survey years; a multivariate logistic regression model was developed to compare differences in using ≥1 formal screening tools across survey years while controlling for various individual and practice characteristics. Pediatricians' use of standardized screening tools increased significantly between 2002 and 2009. The percentage of those who self-reported always/almost always using ≥1 screening tools increased over time (23.0%-47.7%), as did use of specific instruments (eg, Ages & Stages Questionnaire, Parents' Evaluation of Developmental Status). No differences were noted on the basis of physician or practice characteristics. The percentage of pediatricians who reported using ≥1 formal screening tools more than doubled between 2002 and 2009. Despite greater attention to consistent use of appropriate tools, the percentage remains less than half of respondents providing care to patients younger than 36 months. Given the critical importance of developmental screening in early identification, evaluation, and intervention, additional research is needed to identify barriers to greater use of standardized tools in practice. Copyright © 2011 by the American Academy of Pediatrics.

  4. Korean Medication Algorithm Project for Bipolar Disorder: third revision

    Directory of Open Access Journals (Sweden)

    Woo YS

    2015-02-01

    Full Text Available Young Sup Woo,1 Jung Goo Lee,2,3 Jong-Hyun Jeong,1 Moon-Doo Kim,4 Inki Sohn,5 Se-Hoon Shim,6 Duk-In Jon,7 Jeong Seok Seo,8 Young-Chul Shin,9 Kyung Joon Min,10 Bo-Hyun Yoon,11 Won-Myong Bahk1 1Department of Psychiatry, College of Medicine, The Catholic University of Korea, Seoul, South Korea; 2Department of Psychiatry, Inje University Haeundae Paik Hospital, Busan, South Korea;3Paik Institute for Clinical Research, Inje Univeristy, Busan, South Korea; 4Department of Psychiatry, Jeju National University Hospital, Jeju, South Korea; 5Department of Psychiatry, Keyo Hospital, Keyo Medical Foundation, Uiwang, South Korea; 6Department of Psychiatry, Soonchunhyang University Cheonan Hospital, Soonchunhyang University, Cheonan, South Korea; 7Department of Psychiatry, Sacred Heart Hospital, Hallym University, Anyang, South Korea; 8Department of Psychiatry, School of Medicine, Konkuk University, Chungju, South Korea; 9Department of Psychiatry, Kangbuk Samsung Hospital, School of Medicine, Sungkyunkwan University, Seoul, South Korea; 10Department of Psychiatry, College of Medicine, Chung-Ang University, Seoul, South Korea; 11Department of Psychiatry, Naju National Hospital, Naju, South Korea Objective: To constitute the third revision of the guidelines for the treatment of bipolar disorder issued by the Korean Medication Algorithm Project for Bipolar Disorder (KMAP-BP 2014. Methods: A 56-item questionnaire was used to obtain the consensus of experts regarding pharmacological treatment strategies for the various phases of bipolar disorder and for special populations. The review committee included 110 Korean psychiatrists and 38 experts for child and adolescent psychiatry. Of the committee members, 64 general psychiatrists and 23 child and adolescent psychiatrists responded to the survey. Results: The treatment of choice (TOC for euphoric, mixed, and psychotic mania was the combination of a mood stabilizer (MS and an atypical antipsychotic (AAP; the TOC for

  5. Structural and Functional Insights into Aeropyrum pernix OppA, a Member of a Novel Archaeal OppA Subfamily▿ †

    Science.gov (United States)

    Balestrieri, M.; Gogliettino, M.; Fiume, I.; Pocsfalvi, G.; Catara, G.; Rossi, M.; Palmieri, G.

    2011-01-01

    In this study we gain insight into the structural and functional characterization of the Aeropyrum pernix oligopeptide-binding protein (OppAAp) previously identified from the extracellular medium of an Aeropyrum pernix cell culture at late stationary phase. OppAAp showed an N-terminal Q32 in a pyroglutamate form and C-terminal processing at the level of a threonine-rich region probably involved in protein membrane anchoring. Moreover, the OppAAp protein released into the medium was identified as a “nicked” form composed of two tightly associated fragments detachable only under strong denaturing conditions. The cleavage site E569-G570 seems be located on an exposed surface loop that is highly conserved in several three-dimensional (3D) structures of dipeptide/oligopeptide-binding proteins from different sources. Structural and biochemical properties of the nicked protein were virtually indistinguishable from those of the intact form. Indeed, studies of the entire bacterially expressed OppAAp protein owning the same N and C termini of the nicked form supported these findings. Moreover, in the middle exponential growth phase, OppAAp was found as an intact cell membrane-associated protein. Interestingly, the native exoprotein OppAAp was copurified with a hexapeptide (EKFKIV) showing both lysines methylated and possibly originating from an A. pernix endogenous stress-induced lipoprotein. Therefore, the involvement of OppAAp in the recycling of endogenous proteins was suggested to be a potential physiological function. Finally, a new OppA from Sulfolobus solfataricus, SSO1288, was purified and preliminarily characterized, allowing the identification of a common structural/genetic organization shared by all “true” archaeal OppA proteins of the dipeptide/oligopeptide class. PMID:21097609

  6. Association between Ghrelin gene (GHRL polymorphisms and clinical response to atypical antipsychotic drugs in Han Chinese schizophrenia patients

    Directory of Open Access Journals (Sweden)

    Yang Yongfeng

    2012-02-01

    Full Text Available Abstract Background Ghrelin (GHRL is a pivotal peptide regulator of food intake, energy balance, and body mass. Weight gain (WG is a common side effect of the atypical antipsychotics (AAPs used to treat schizophrenia (SZ. Ghrelin polymorphisms have been associated with pathogenic variations in plasma lipid concentrations, blood pressure, plasma glucose, and body mass index (BMI. However, it is unclear whether GHRL polymorphisms are associated with WG due to AAPs. Furthermore, there is no evidence of an association between GHRL polymorphisms and SZ or the therapeutic response to AAPs. We explored these potential associations by genotyping GHRL alleles in SZ patients and controls. We also examined the relation between these SNPs and changes in metabolic indices during AAP treatment in SZ subgroups distinguished by high or low therapeutic response. Methods Four SNPs (Leu72Met, -501A/C, -604 G/A, and -1062 G > C were genotyped in 634 schizophrenia patients and 606 control subjects. Results There were no significant differences in allele frequencies, genotype distributions, or the distributions of two SNP haplotypes between SZ patients and healthy controls (P > 0.05. There was also no significant difference in symptom reduction between genotypes after 8 weeks of AAP treatment as measured by positive and negative symptom scale scores (PANSS. However, the -604 G/A polymorphism was associated with a greater BMI increase in response to AAP administration in both APP responders and non-responders as distinguished by PANSS score reduction (P P Conclusions These four GHRL gene SNPs were not associated with SZ in this Chinese Han population. The -604 G/A polymorphism was associated with significant BW and BMI increases during AAP treatment. Patients exhibiting higher WG showed greater improvements in positive and negative symptoms than patients exhibiting lower weight gain or weight loss.

  7. Transformation of acetaminophen during water chlorination treatment: kinetics and transformation products identification.

    Science.gov (United States)

    Cao, Fei; Zhang, Mengtao; Yuan, Shoujun; Feng, Jingwei; Wang, Qiquan; Wang, Wei; Hu, Zhenhu

    2016-06-01

    As a high-consumption drug in the world, acetaminophen (AAP) has been widely detected in natural waters and wastewaters. Its reactivity and the transformation products formed during chlorination may greatly threaten the safety of drinking water. The reaction kinetics of AAP during chlorination was investigated in this study. The results showed that the reaction kinetics could be well described with a kinetics model of -d[AAP]/dt = k app[AAP]t (0.63)[Cl2]t (1.37). The values of apparent rate constant (k app) were dependent on reaction temperature, ammonium, and pH. With the increase in reaction temperature from 5.0 ± 1.0 to 40.0 ± 1.0 °C, the removal efficiency of AAP increased from 60 to 100 %. When ammonium was present in the solution at 2.0 mg/L, the transformation of AAP was inhibited due to the rapid formation of chloramines. The maximum of k app was 0.58 × 10(2) M(-1) · min(-1) at pH 9.0, and the minimum was 0.27 M(-1) · min(-1) at pH 11.0. A low mineralization of AAP (about 7.2 %) with chlorination was observed through TOC analysis, implying the formation of plenty of transformation products during chlorination. The main transformation products, hydroquinone and two kinds of chlorinated compounds, monochlorinated acetaminophen and dichlorinated acetaminophen, were detected in gas chromatography-mass spectrometry analysis.

  8. Ultrasonic degradation of acetaminophen and naproxen in the presence of single-walled carbon nanotubes

    Energy Technology Data Exchange (ETDEWEB)

    Im, Jong-Kwon; Heo, Jiyong; Boateng, Linkel K. [Department of Civil and Environmental Engineering, University of South Carolina, Columbia, SC 29208 (United States); Her, Namguk [Department of Chemistry and Environmental Sciences, Korea Army Academy at Young-Cheon, 135-1, Changhari, Kokyungmeon, Young-cheon, Gyeongbuk 770-849 (Korea, Republic of); Flora, Joseph R.V. [Department of Civil and Environmental Engineering, University of South Carolina, Columbia, SC 29208 (United States); Yoon, Jaekyung [Korea Institute of Energy Research, New and Renewable Energy Research Division, 71-2 Jang-Dong, Yuseong-Gu, Daejeon 305-343 (Korea, Republic of); Zoh, Kyung-Duk [Department of Environmental Health, School of Public Health, Seoul National University, Seoul 151-742 (Korea, Republic of); Yoon, Yeomin, E-mail: yoony@cec.sc.edu [Department of Civil and Environmental Engineering, University of South Carolina, Columbia, SC 29208 (United States)

    2013-06-15

    Highlights: • Sonodegradation of acetaminophen and naproxen was performed. • Degradation was enhanced with the dispersion of SWNTs under US irradiation. • Synergistic effect on the degradation PhACs was observed in US/SWNT process. • Significant removal of dissolved organic carbon was achieved. -- Abstract: Ultrasonic (US) and single-walled carbon nanotube (SWNT)-catalyzed ultrasonic (US/SWNT) degradation of a pharmaceutical (PhAC) mixture of acetaminophen (AAP) and naproxen (NPX) used as analgesics was carried out in water. In the absence of SWNTs, maximum degradations of AAP and NPX occurred at a high frequency (1000 kHz) and under acidic conditions (pH 3) and different solution temperatures (25 °C at 28 kHz and 35 °C at 1000 kHz) during US reactions. Rapid degradation of PhACs occurred within 10 min at 28 kHz (44.5% for AAP; 90.3% for NPX) and 1000 kHz (39.2% for AAP; 74.8% for NPX) at a SWNT concentration of 45 mg L{sup −1} under US/SWNT process, compared with 28 kHz (5.2% for AAP; 10.6% for NPX) and 1000 kHz (29.1% for AAP; 46.2% for NPX) under US process. Degradation was associated with the dispersion of SWNTs; small particles acted as nuclei during US reactions, enhancing the H{sub 2}O{sub 2} production yield. NPX removal was greater than AAP removal under all US-induced reaction and SWNT adsorption conditions, which is governed by the chemical properties of PhACs. Based on the results, the optimal treatment performance was observed at 28 kHz with 45 mg L{sup −1} SWNTs (US/SWNT) within 10 min.

  9. Impact of atypical antipsychotic use among adolescents with attention-deficit/hyperactivity disorder.

    Science.gov (United States)

    Sikirica, Vanja; Pliszka, Steven R; Betts, Keith A; Hodgkins, Paul; Samuelson, Thomas M; Xie, Jipan; Erder, M Haim; Dammerman, Ryan S; Robertson, Brigitte; Wu, Eric Q

    2014-09-01

    To compare treatment patterns, resource utilization, and costs to US third-party payers of stimulant-treated adolescent attentiondeficit/ hyperactivity disorder (ADHD) patients who switched to or augmented with atypical antipsychotics (AAPs; not FDA-indicated for ADHD) with those who switched to or augmented with nonantipsychotic medications. Retrospective cohort study conducted using a US commercial medical/pharmacy claims database. Adolescent patients with an ADHD diagnosis and ≥ 1 stimulant medication claim between January 2005 and December 2009 were identified. Patients were classified into the AAP or non-antipsychotic cohorts based on subsequent claims for AAPs or non-antipsychotic medications, respectively. Patients with psychiatric diagnoses for which AAPs are often prescribed were excluded. Patients were matched 1:1 from the AAP to the non-antipsychotic cohort using propensity score matching. Treatment patterns, resource utilization, and costs in the 12 months after AAP or non-antipsychotic initiation were compared using Cox models, Poisson regression, and Wilcoxon signed-rank tests, respectively. After propensity score matching, a total of 849 adolescents were included in each of the matched cohorts. Patients in the AAP cohort had a significantly higher rate of medication augmentation (27.7% vs 15.5%; hazard ratio = 2.56; 95% confidence interval [CI], 1.90-3.46; P < .001) than patients in the non-antipsychotic cohort. The AAP cohort also had significantly higher incidences of inpatient admissions (0.13 vs 0.05; incidence rate ratio [IRR] = 2.45; 95% CI, 1.73-3.48; P < .001), emergency department visits (0.39 vs 0.31; IRR = 1.27; 95% CI, 1.08-1.49; P = .004), and outpatient visits (14.82 vs 13.19; IRR = 1.12; 95% CI, 1.10-1.15; P < .001), and incurred significantly higher mean annual medical ($3622 vs $3311; P = .002), drug ($4314 vs $2884; P < .001), and total healthcare ($7936 vs $6195; P < .001) costs. Stimulant-treated adolescents with ADHD who

  10. Photoheterotrophic Microbes in the Arctic Ocean in Summer and Winter▿

    Science.gov (United States)

    Cottrell, Matthew T.; Kirchman, David L.

    2009-01-01

    Photoheterotrophic microbes, which are capable of utilizing dissolved organic materials and harvesting light energy, include coccoid cyanobacteria (Synechococcus and Prochlorococcus), aerobic anoxygenic phototrophic (AAP) bacteria, and proteorhodopsin (PR)-containing bacteria. Our knowledge of photoheterotrophic microbes is largely incomplete, especially for high-latitude waters such as the Arctic Ocean, where photoheterotrophs may have special ecological relationships and distinct biogeochemical impacts due to extremes in day length and seasonal ice cover. These microbes were examined by epifluorescence microscopy, flow cytometry, and quantitative PCR (QPCR) assays for PR and a gene diagnostic of AAP bacteria (pufM). The abundance of AAP bacteria and PR-containing bacteria decreased from summer to winter, in parallel with a threefold decrease in the total prokaryotic community. In contrast, the abundance of Synechococcus organisms did not decrease in winter, suggesting that their growth was supported by organic substrates. Results from QPCR assays revealed no substantial shifts in the community structure of AAP bacteria and PR-containing bacteria. However, Arctic PR genes were different from those found at lower latitudes, and surprisingly, they were not similar to those in Antarctic coastal waters. Photoheterotrophic microbes appear to compete successfully with strict heterotrophs during winter darkness below the ice, but AAP bacteria and PR-containing bacteria do not behave as superior competitors during the summer. PMID:19502441

  11. Ecology of aerobic anoxygenic phototrophic bacteria along an oligotrophic gradient in the Mediterranean Sea

    Directory of Open Access Journals (Sweden)

    D. Lamy

    2011-04-01

    Full Text Available Aerobic anoxygenic phototrophic (AAP bacteria are photoheterotrophic prokaryotes able to use both light and organic substrates for energy production. They are widely distributed in coastal and oceanic environments and may contribute significantly to the carbon cycle in the upper ocean. To better understand questions regarding links between the ecology of these photoheterotrophic bacteria and the trophic status of water masses, we examined their horizontal and vertical distribution and the effects of nutrient additions on their growth along an oligotrophic gradient in the Mediterranean Sea. Concentrations of bacteriochlorophyll-a (BChl-a and AAP bacterial abundance decreased from the western to the eastern basin of the Mediterranean Sea and were linked with concentrations of chlorophyll-a, nutrient and dissolved organic carbon. Inorganic nutrient and glucose additions to surface seawater samples along the oligotrophic gradient revealed that AAP bacteria were nitrogen- and carbon-limited in the ultraoligotrophic eastern basin. The intensity of the AAP bacterial growth response generally differed from that of the total bacterial growth response. BChl-a quota of AAP bacterial communities was significantly higher in the eastern basin than in the western basin, suggesting that reliance on phototrophy varied along the oligotrophic gradient and that nutrient and/or carbon limitation favors BChl-a synthesis.

  12. Status and strategies analysis on international standardization of auricular acupuncture points.

    Science.gov (United States)

    Wang, Lei; Zhao, Baixiao; Zhou, Liqun

    2013-06-01

    To supply literature for developing an international standard of auricular acupuncture points. Electronic database searches were conducted in the Chinese National Knowledge Infrastructure and VIP, and the Western databases, Pubmed, the National Science and Technology Library, and the German Journal of Acupuncture, from 1990 to April, 2012. We also searched the documents of international symposiums for auricular acupuncture points (AAPs). Keywords were "auricular points", "auricular acupuncture points", "ear points", or "auriculotherapy". Basic and clinical research on AAPs was performed in China, the United States, France, and Germany. Clinical AAP research was done in Italy, Austria, Switzerland, Spain, the UK, Holland, Japan, Russia, and Africa. However, AAP research was not communicated internationally. The World Federation of Acupuncture-Moxibustion Societies recommended international standard of auricular acupuncture points (ISAAPs). Standardized nomenclature and locations of AAPs would provide a solid basis to draft an international standard organization. Experts need to find common points from different countries or regions, provide evidence of different ideas, and list the proposal as a recommendation for an international standard.

  13. Atypical antipsychotics in the treatment of early-onset schizophrenia

    Directory of Open Access Journals (Sweden)

    Hrdlicka M

    2015-04-01

    Full Text Available Michal Hrdlicka, Iva Dudova Department of Child Psychiatry, Charles University Second Faculty of Medicine and University Hospital Motol, Prague, Czech Republic Abstract: Atypical antipsychotics (AAPs have been successfully used in early-onset schizophrenia (EOS. This review summarizes the randomized, double-blind, controlled studies of AAPs in EOS, including clozapine, risperidone, olanzapine, aripiprazole, paliperidone, quetiapine, and ziprasidone. No significant differences in efficacy between AAPs were found, with the exception of clozapine and ziprasidone. Clozapine demonstrated superior efficacy in treatment-resistant patients with EOS, whereas ziprasidone failed to demonstrate efficacy in the treatment of EOS. Our review also focuses on the onset of action and weight gain associated with AAPs. The data on onset of action of AAPs in pediatric psychiatry are scanty and inconsistent. Olanzapine appears to cause the most significant weight gain in patients with EOS, while ziprasidone and aripiprazole seem to cause the least. Keywords: early-onset schizophrenia, atypical antipsychotics, efficacy, onset of action, weight gain

  14. Blonanserin Augmentation of Atypical Antipsychotics in Patients with Schizophrenia-Who Benefits from Blonanserin Augmentation?: An Open-Label, Prospective, Multicenter Study.

    Science.gov (United States)

    Woo, Young Sup; Park, Joo Eon; Kim, Do-Hoon; Sohn, Inki; Hwang, Tae-Yeon; Park, Young-Min; Jon, Duk-In; Jeong, Jong-Hyun; Bahk, Won-Myong

    2016-07-01

    The purpose of this study was to investigate the efficacy and tolerability of atypical antipsychotics (AAPs) with augmentation by blonanserin in schizophrenic patients. aA total of 100 patients with schizophrenia who were partially or completely unresponsive to treatment with an AAP were recruited in this 12-week, open-label, non-comparative, multicenter study. Blonanserin was added to their existing AAP regimen, which was maintained during the study period. Efficacy was primarily evaluated using the Positive and Negative Syndrome Scale (PANSS) at baseline and at weeks 2, 4, 8, and 12. Predictors for PANSS response (≥20% reduction) were investigated. The PANSS total score was significantly decreased at 12 weeks of blonanserin augmentation (-21.0±18.1, F=105.849, pblonanserin occurred in 17 patients (17.0%); 4 of these patients dropped out due to adverse events. The patients who benefited the most from blonanserin were those with severe symptoms despite a treatment with a higher dose of AAP. Blonanserin augmentation could be an effective strategy for patients with schizophrenia who were partially or completely unresponsive to treatment with an AAP.

  15. Diagnostic Accuracy of Two Food Insecurity Screeners Recommended for Use in Health Care Settings.

    Science.gov (United States)

    Makelarski, Jennifer A; Abramsohn, Emily; Benjamin, Jasmine H; Du, Senxi; Lindau, Stacy Tessler

    2017-11-01

    To test the diagnostic accuracy of the American Academy of Pediatrics (AAP) recommended food insecurity screener. We conducted prospective diagnostic accuracy studies between July and November 2016 in Chicago, Illinois. We recruited convenience samples of adults from adult and pediatric emergency departments (12-month recall study: n = 188; 30-day recall study: n = 154). A self-administered survey included the 6-item Household Food Security Screen (gold standard), the validated 2-item Hunger Vital Sign (HVS; often, sometimes, never response categories), and the 2-item AAP tool (yes-or-no response categories). Food insecurity was prevalent (12-month recall group: 46%; 30-day group: 39%). Sensitivity of the AAP tool using 12-month and 30-day recall was, respectively, 76% (95% confidence interval [CI] = 65%, 85%) and 72% (95% CI = 57%, 84%). The HVS sensitivity was significantly higher than the AAP tool (12-month: 94% [95% CI = 86%, 98%; P = .002]; 30-day: 92% [95% CI = 79%, 98%; P = .02]). The AAP tool missed nearly a quarter of food-insecure adults screened in the hospital; the HVS screening tool was more sensitive. Public health implications. Health care systems adopting food insecurity screening should optimize ease of administration and sensitivity of the screening tool.

  16. Templated nucleation of acetaminophen on spherical excipient agglomerates.

    Science.gov (United States)

    Quon, Justin L; Chadwick, Keith; Wood, Geoffrey P F; Sheu, Iris; Brettmann, Blair K; Myerson, Allan S; Trout, Bernhardt L

    2013-03-12

    We investigated the effect of spherical agglomeration of heterogeneous crystalline substrates on the nucleation of acetaminophen (AAP). Optical and electron microscopy showed that the surface morphologies of single crystal triclinic lactose and D-mannitol differed significantly from their counterparts formed via spherical agglomeration. Spherical agglomerates of lactose were shown to enhance the nucleation rate of acetaminophen (AAP) by a factor of 11 compared to single crystal lactose; however, no such enhancement was observed for D-mannitol. X-ray powder diffraction identified the presence of new crystal faces of lactose present only in the spherical agglomerates However, D-mannitol did not show any significant change in crystal morphology. The new crystal faces of triclinic lactose were analyzed using geometric lattice matching software and molecular dynamics simulations to establish any new and significant epitaxial matches between lactose and AAP. A coincident lattice match and a large favorable energy interaction from hydrogen bonding were observed between the (141¯) and (001) crystal faces of lactose and AAP, respectively. The enhanced nucleation kinetics, X-ray data, and computational studies indicated that the spherical crystallization of lactose exposed the (141¯) face on the surface of the agglomerates, which subsequently enhanced the nucleation rate of AAP through geometric lattice matching and molecular functionality. This study highlights the importance of exploring different heterogeneous substrate morphologies for enhancing nucleation kinetics.

  17. Bioenergetics of photoheterotrophic bacteria in the oceans.

    Science.gov (United States)

    Kirchman, David L; Hanson, Thomas E

    2013-04-01

    Photoheterotrophic microbes, such as proteorhodopsin (PR)-based phototrophic (PRP) and aerobic anoxygenic phototrophic (AAP) bacteria, are well known to be abundant in the oceans, potentially playing unique roles in biogeochemical cycles. However, the contribution of phototrophy to the energy requirements of these bacteria has not been quantitatively examined to date. To better understand the implications of photoheterophy in the oceans, we calculated energy benefits and costs of phototrophy and compared net benefits with maintenance costs. Benefits depend on the number of photosynthetic units (PSUs), absorption cross-section area of each PSU as function of wavelength, the in situ light quality, and the energy yield per absorbed photon. For costs we considered the energy required for the synthesis of pigments, amino acids and proteins in each PSU. Our calculations indicate that AAP bacteria harvest more light energy than do PRP bacteria, but the costs of phototrophy are much higher for AAP bacteria. Still, the net energy gained by AAP bacteria is often sufficient to meet maintenance costs, while that is not the case for PRP bacteria except with high light intensities and large numbers of proteorhodopsin molecules per cell. The low costs and simplicity of PR-based phototrophy explain the high abundance of proteorhodopsin genes in the oceans. However, even for AAP bacteria, the net energy yield of phototrophy is apparently too low to influence the distribution of photoheterotrophic bacteria among various marine systems. © 2012 Society for Applied Microbiology and Blackwell Publishing Ltd.

  18. Optimising contributions of goat farming to household economic success and food security in three production systems in Ethiopia

    Directory of Open Access Journals (Sweden)

    Tatek Woldu

    2016-03-01

    Full Text Available The study aims to analyse factors affecting contributions of goat farming to household economic success and food security in three goat production systems of Ethiopia. A study was conducted in three districts of Ethiopia representing arid agro-pastoral (AAP, semi-arid agro-pastoral (SAAP and highland mixed crop-livestock (HMCL systems involving 180 goat keeping households. Gross margin (GM and net benefit (NB1 and NB2 were used as indicators of economic success of goat keeping. NB1 includes in-kind benefits of goats (consumption and manure, while NB2 additionally constitutes intangible benefits (insurance and finance. Household dietary diversity score (HDDS was used as a proxy indicator of food security. GM was significantly affected by an off-take rate and flock size interaction (P0.05. Nevertheless, a significant positive correlation (P<0.05 was observed between GM from goats and HDDS in AAP system, indicating the indirect role of goat production for food security. The study indicated that extent of utilising tangible and intangible benefits of goats varied among production systems and these differences should be given adequate attention in designing genetic improvement programs.

  19. Modeling Multioperator Multi-UAV Operator Attention Allocation Problem Based on Maximizing the Global Reward

    Directory of Open Access Journals (Sweden)

    Yuhang Wu

    2016-01-01

    Full Text Available This paper focuses on the attention allocation problem (AAP in modeling multioperator multi-UAV (MOMU, with the operator model and task properties taken into consideration. The model of MOMU operator AAP based on maximizing the global reward is established and used to allocate tasks to all operators as well as set work time and rest time to each task simultaneously for operators. The proposed model is validated in Matlab simulation environment, using the immune algorithm and dynamic programming algorithm to evaluate the performance of the model in terms of the reward value with regard to the work time, rest time, and task allocation. The result shows that the total reward of the proposed model is larger than the one obtained from previously published methods using local maximization and the total reward of our method has an exponent-like relation with the task arrival rate. The proposed model can improve the operators’ task processing efficiency in the MOMU command and control scenarios.

  20. The correlates of preschoolers' compliance with screen recommendations exist across multiple domains.

    Science.gov (United States)

    Hinkley, Trina; Salmon, Jo; Okely, Anthony D; Crawford, David

    2013-09-01

    To investigate the individual, social and physical environment correlates of preschool children's compliance with Australian/Canadian and American Academy of Pediatrics (AAP) screen recommendations. An Ecological Model (EM) was used to identify constructs potentially associated with children's screen time. In 2008-2009, parents in Melbourne, Australia, reported their child's screen time and on a range of potential correlates. Children (n = 935; 54% boys, mean age 4.54 ± 0.70 years) were assessed as meeting or not meeting each of the screen recommendations. Logistic regression assessed bivariable and multivariable associations. In total, 15 explanatory variables, across the three domains of the EM were associated with boys' and/or girls' compliance with either Australian/Canadian or AAP recommendations. Correlates varied by sex and recommendation. Maternal television viewing time was the only consistent correlate for both boys' and girls' compliance with both recommendations. No demographic groups were identified as being less likely to comply with screen recommendations. Public health programs should take account of the sex-specific nature of correlates of preschool children's screen time. Preschool children across all demographic groups need support to engage in less screen use. Parents may benefit from education and parenting skills to minimize potentially harmful effects of excessive screen time for their child. Copyright © 2013 Elsevier Inc. All rights reserved.

  1. Principles of Child Health Care Financing.

    Science.gov (United States)

    Hudak, Mark L; Helm, Mark E; White, Patience H

    2017-09-01

    After passage of the Patient Protection and Affordable Care Act, more children and young adults have become insured and have benefited from health care coverage than at any time since the creation of the Medicaid program in 1965. From 2009 to 2015, the uninsurance rate for children younger than 19 years fell from 9.7% to 5.3%, whereas the uninsurance rate for young adults 19 to 25 years of age declined from 31.7% to 14.5%. Nonetheless, much work remains to be done. The American Academy of Pediatrics (AAP) believes that the United States can and should ensure that all children, adolescents, and young adults from birth through the age of 26 years who reside within its borders have affordable access to high-quality and comprehensive health care, regardless of their or their families' incomes. Public and private health insurance should safeguard existing benefits for children and take further steps to cover the full array of essential health care services recommended by the AAP. Each family should be able to afford the premiums, deductibles, and other cost-sharing provisions of the plan. Health plans providing these benefits should ensure, insofar as possible, that families have a choice of professionals and facilities with expertise in the care of children within a reasonable distance of their residence. Traditional and innovative payment methodologies by public and private payers should be structured to guarantee the economic viability of the pediatric medical home and of other pediatric specialty and subspecialty practices to address developing shortages in the pediatric specialty and subspecialty workforce, to promote the use of health information technology, to improve population health and the experience of care, and to encourage the delivery of evidence-based and quality health care in the medical home, as well as in other outpatient, inpatient, and home settings. All current and future health care insurance plans should incorporate the principles for child

  2. An evaluation of plastic surgery resident selection factors.

    Science.gov (United States)

    Liang, Fan; Rudnicki, Pamela A; Prince, Noah H; Lipsitz, Stuart; May, James W; Guo, Lifei

    2015-01-01

    Our purpose was to provide a metric by which evaluation criteria are prioritized during resident selection. In this study, we assessed which residency applicant qualities are deemed important by members of the American Association of Plastic Surgeons (AAPS). A survey was distributed to all 580 AAPS members, and 295 responded to rate the importance of resident metrics, including measures of competency and personal characteristics. Demographic information, background training, and interaction with residents were also noted. Using SAS v9.2 (SAS Institute, Cary, NC), outcomes were analyzed across demographic groups with column trend exact (CTE) test for ordinal variables, Mantel-Haenszel trend test for interval variables, and Fisher exact test for discrete variables. Regarding competency metrics, letters of recommendation from known sources is the most important factor, whereas letters from unknown sources ranks the lowest. Character evaluations identified honesty as the most desirable trait; dishonesty was the most despised. Across demographic groups, academic surgeons and program directors value letters from known sources more than nonacademicians or nonprogram directors (CTE p = 0.005 and 0.002, respectively). Academicians and current program directors regard research more highly than their counterparts do (CTE p = 0.022 and 0.022, respectively). Currently, practicing surgeons, academicians, and program directors value hard work more than others (CTE p = 0.008, 0.033, and 0.029, respectively). Program directors emphasize maturity and patient commitment and are less tolerant of narcissism (CTE p = 0.002, 0.005, and 0.003, respectively). Lastly, academic surgeons and program directors look more favorably upon strong team players (CTE p < 0.00001 and p = 0.008, respectively), but less so over time (Mantel-Haenszel trend p = 0.006). We have examined applicant metrics that were deemed important by AAPS members and assessed their demographic interpretation. We hope this

  3. Use of the Adult Attachment Projective Picture System in an assessment of an adolescent in foster care.

    Science.gov (United States)

    Webster, Linda; Joubert, David

    2011-01-01

    Child maltreatment has been associated with a host of negative outcomes including impaired social relationships (Rogosch, Cicchetti, & Aber, 1995), depression (Toth, Manly, & Cicchetti, 1992), poor self-concept and motivation (Vondra, Barnett, & Cicchetti, 1990), and delinquency and conduct problems (Cook et al., 2005; Grotevant et al., 2006; McCabe, Lucchini, Hough, Yeh, & Hazen, 2005; Ryan & Testa, 2005). An assessment of the mental representation of attachment relationships could offer additional relevant and useful information to the evaluation of youth in foster care, and could inform treatment and placement considerations. The Adult Attachment Projective Picture System (AAP) is a relatively new measure of internal representations of attachment based on the analysis of a set of stimuli designed to systematically activate the attachment system (George, West, & Pettem, 1997). This article considers the use of the AAP with a maltreated adolescent in a clinical setting and uses a case study to illustrate the components of the AAP that are particularly relevant to case conceptualization and interventions.

  4. Growth and nutritional status of children from dysfunctional families with alcohol addicted parents in Poland.

    Science.gov (United States)

    Hanć, Tomasz; Czapla, Zbigniew; Szwed, Anita; Durda, Magdalena; Krotowska, Aleksandra; Cieślik, Joachim

    2015-07-01

    The study was aimed at assessment of impact of parents' alcohol addiction on growth and prevalence of underweight and overweight in their children. Two groups of subjects were compared: 80 children of alcohol addicted parents (ChAAP) aged from 7 to 14 years and reference group (RG) of 1000 children selected in terms of age and place of residence. Differences in z scores for height and Body Mass Index (BMI), prevalence of underweight and overweight were assessed. Families of ChAAP were characterized by: lower parents' education, higher unemployment rate, a greater number of children than in RG. The differences between ChAAP and RG in z scores for height (z scores: -0.54 vs. 0.45, t = -7.01, p development. Copyright © 2015 Elsevier B.V. All rights reserved.

  5. Updated parental viewpoints on male neonatal circumcision in the United States.

    Science.gov (United States)

    Wang, Marvin L; Macklin, Eric A; Tracy, Erin; Nadel, Hiyam; Catlin, Elizabeth A

    2010-02-01

    Through a questionnaire, the authors sought to elicit information about initial attitudes concerning circumcision after reading a summary of the American Academy of Pediatrics (AAP) Policy Statement and, again, after reading a description of recent HIV/HPV studies. Predictors of increased support for circumcision included having a prior circumcised boy and being US born. Predictors of decreased support included being of Hispanic ethnicity and believing that the uncircumcised penis was more culturally normal. After reading the AAP statement, 86% of respondents remained favorable of elective circumcision, whereas 13% viewed it less favorably. After reading the passage about the HIV/HPV studies, the majority maintained their initial level of support. Certain characteristics were associated with an individual's desire to perform circumcision on his/her infant. Despite a slight decrease in support to perform circumcision after reading the AAP policy summary, respondents' initial attitudes toward circumcision were unchanged after subsequent review of recent HIV/HPV research.

  6. Nano-TiO2, ultrasound and sequential nano-TiO2/ultrasonic degradation of N-acetyl-para-aminophenol from aqueous solution.

    Science.gov (United States)

    Ayanda, Olushola S; Nelana, Simphiwe M; Petrik, Leslie F; Naidoo, Eliazer B

    2017-10-01

    The application of nano-TiO2 as adsorbent combined with ultrasound for the degradation of N-acetyl-para-aminophenol (AAP) from aqueous solution was investigated. The nano-TiO2 was characterized by means of powder X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy dispersive spectroscopy (EDS), and attenuated total reflection-Fourier transform infrared spectroscopy (ATR-FTIR). Experimental results revealed that the adsorption of AAP by nano-TiO2 fitted the pseudo-second-order kinetic model, the equilibrium could be explained by the Freundlich isotherm and the treatment process is exothermic. The optimum removal efficiency of AAP (128.89 mg/g (77.33%)) was achieved at pH 4 when 0.03 g of nano-TiO2 was mixed with 50 mL of 100 mg/L AAP aqueous solution at ambient temperature, 60 min contact time, and a stirring speed of 120 rpm. Ultrasound at 20 kHz and pH 3 was favorable and it resulted in 52.61% and 57.43% removal efficiency with and without the addition of nano-TiO2, respectively. The degradation of AAP by ultrasound followed by nano-TiO2 treatment resulted in approximately 99.50% removal efficiency. This study showed that a sequential ultrasound and nano-TiO2 treatment process could be employed for the removal of AAP or other emerging water and wastewater contaminants.

  7. Cationic Amino Acid Uptake Constitutes a Metabolic Regulation Mechanism and Occurs in the Flagellar Pocket of Trypanosoma cruzi

    Science.gov (United States)

    Bouvier, León A.; Cámara, María de los Milagros; Montserrat, Javier; Pereira, Claudio A.

    2012-01-01

    Trypanosomatids' amino acid permeases are key proteins in parasite metabolism since they participate in the adaptation of parasites to different environments. Here, we report that TcAAP3, a member of a Trypanosoma cruzi multigene family of permeases, is a bona fide arginine transporter. Most higher eukaryotic cells incorporate cationic amino acids through a single transporter. In contrast, T. cruzi can recognize and transport cationic amino acids by mono-specific permeases since a 100-fold molar excess of lysine could not affect the arginine transport in parasites that over-express the arginine permease (TcAAP3 epimastigotes). In order to test if the permease activity regulates downstream processes of the arginine metabolism, the expression of the single T. cruzi enzyme that uses arginine as substrate, arginine kinase, was evaluated in TcAAP3 epimastigotes. In this parasite model, intracellular arginine concentration increases 4-folds and ATP level remains constant until cultures reach the stationary phase of growth, with decreases of about 6-folds in respect to the controls. Interestingly, Western Blot analysis demonstrated that arginine kinase is significantly down-regulated during the stationary phase of growth in TcAAP3 epimastigotes. This decrease could represent a compensatory mechanism for the increase in ATP consumption as a consequence of the displacement of the reaction equilibrium of arginine kinase, when the intracellular arginine concentration augments and the glucose from the medium is exhausted. Using immunofluorescence techniques we also determined that TcAAP3 and the specific lysine transporter TcAAP7 co-localize in a specialized region of the plasma membrane named flagellar pocket, staining a single locus close to the flagellar pocket collar. Taken together these data suggest that arginine transport is closely related to arginine metabolism and cell energy balance. The clinical relevance of studying trypanosomatids' permeases relies on the

  8. Pro-oxidant status and matrix metalloproteinases in apical lesions and gingival crevicular fluid as potential biomarkers for asymptomatic apical periodontitis and endodontic treatment response

    Directory of Open Access Journals (Sweden)

    Dezerega Andrea

    2012-03-01

    Full Text Available Abstract Background Oxidative stress and matrix metalloproteinases -9 and -2 are involved in periodontal breakdown, whereas gingival crevicular fluid has been reported to reflect apical status. The aim of this study was to characterize oxidant balance and activity levels of MMP -2 and -9 in apical lesions and healthy periodontal ligament; and second, to determine whether potential changes in oxidant balance were reflected in gingival crevicular fluid from asymptomatic apical periodontitis (AAP-affected teeth at baseline and after endodontic treatment. Methods Patients with clinical diagnosis of AAP and healthy volunteers having indication of tooth extraction were recruited. Apical lesions and healthy periodontal ligaments, respectively, were homogenized or processed to obtain histological tissue sections. Matrix metalloproteinase -9 and -2 levels and/or activity were analyzed by Immunowestern blot, zymography and consecutive densitometric analysis, and their tissue localization was confirmed by immunohistochemistry. A second group of patients with AAP and indication of endodontic treatment was recruited. Gingival crevicular fluid was extracted from AAP-affected teeth at baseline, after endodontic treatment and healthy contralateral teeth. Total oxidant and antioxidant status were determined in homogenized tissue and GCF samples. Statistical analysis was performed using STATA v10 software with unpaired t test, Mann-Whitney test and Spearman's correlation. Results Activity of MMP-2 and MMP-9 along with oxidant status were higher in apical lesions (p Conclusions Apical lesions display an oxidant imbalance along with increased activity of matrix metalloproteinase-2 and -9 and might contribute to AAP progression. Oxidant imbalance can also be reflected in GCF from AAP-affected teeth and was restored to normal levels after conservative endodontic treatment. These mediators might be useful as potential biomarkers for chair-side complementary diagnostic

  9. Are specific initiatives required to enhance prescribing of generic atypical antipsychotics in Scotland?: International implications.

    Science.gov (United States)

    Bennie, M; Bishop, I; Godman, B; Barbui, C; Raschi, E; Campbell, S; Miranda, J; Gustafsson, L L

    2013-02-01

    National and regional authorities in Scotland have introduced multiple measures to appreciably enhance prescribing efficiency for the proton pump inhibitors (PPIs), statins and renin-angiotensin inhibitor drugs. Generic oral risperidone recently became available in Scotland; however, schizophrenia is a complex disease with advice from respected authorities suggesting that treatment should be individualised. To assess (i) changes in atypical antipsychotic drug (AAP) utilisation and expenditure following the availability of oral generic risperidone in Scotland; (ii) to determine (a) current INN prescribing rates for risperidone following generic availability and (b) decrease in expenditure/DDD for generic risperidone; (iii) to suggest additional measures that could possibly be introduced in Scotland to further enhance prescribing of generic AAPs; and (iv) to provide guidance to NHS Scotland as well as other European authorities on the implications. Retrospective observational study and an interrupted time series design. No appreciable change in the utilisation patterns of risperidone pre- and postgeneric availability. Appreciable INN prescribing averaged 93-98% of total oral risperidone. Generic risperidone was 84% below prepatent loss prices by study end, reducing annual expenditure for oral risperidone in 2010 by GB£3.19mn compared with prepatent loss situation. However, overall expenditure on AAPs increased by 42% from 2005 to 2010. As expected, there was no change in utilisation patterns for risperidone, although potential to influence prescribing patterns. Continued high INN prescribing suggests no problems with generic risperidone in practice. Costs will start to decrease as more AAPs lose their patents (olanzapine and quetiapine). There is the possibility to accelerate this reduction through educational activities. There is potential to realise some savings with generic AAPs. However, this is limited by the complexity of the disease area. Any measures

  10. Improved Anticancer Photothermal Therapy Using the Bystander Effect Enhanced by Antiarrhythmic Peptide Conjugated Dopamine-Modified Reduced Graphene Oxide Nanocomposite.

    Science.gov (United States)

    Yu, Jiantao; Lin, Yu-Hsin; Yang, Lingyan; Huang, Chih-Ching; Chen, Liliang; Wang, Wen-Cheng; Chen, Guan-Wen; Yan, Junyan; Sawettanun, Saranta; Lin, Chia-Hua

    2017-01-01

    Despite tremendous efforts toward developing novel near-infrared (NIR)-absorbing nanomaterials, improvement in therapeutic efficiency remains a formidable challenge in photothermal cancer therapy. This study aims to synthesize a specific peptide conjugated polydopamine-modified reduced graphene oxide (pDA/rGO) nanocomposite that promotes the bystander effect to facilitate cancer treatment using NIR-activated photothermal therapy. To prepare a nanoplatform capable of promoting the bystander effect in cancer cells, we immobilized antiarrhythmic peptide 10 (AAP10) on the surface of dopamine-modified rGO (AAP10-pDA/rGO). Our AAP10-pDA/rGO could promote the bystander effect by increasing the expression of connexin 43 protein in MCF-7 breast-cancer cells. Because of its tremendous ability to absorb NIR absorption, AAP10-pDA/rGO offers a high photothermal effect under NIR irradiation. This leads to a massive death of MCF-7 cells via the bystander effect. Using tumor-bearing mice as the model, it is found that NIR radiation effectively ablates breast tumor in the presence of AAP10-pDA/rGO and inhibits tumor growth by ≈100%. Therefore, this research integrates the bystander and photothermal effects into a single nanoplatform in order to facilitate an efficient photothermal therapy. Furthermore, our AAP10-pDA/rGO, which exhibits both hyperthermia and the bystander effect, can prevent breast-cancer recurrence and, therefore, has great potential for future clinical and research applications. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  11. Staphylococcus epidermidis Uses Distinct Mechanisms of Biofilm Formation To Interfere with Phagocytosis and Activation of Mouse Macrophage-Like Cells 774A.1 ▿

    Science.gov (United States)

    Schommer, Nina N.; Christner, Martin; Hentschke, Moritz; Ruckdeschel, Klaus; Aepfelbacher, Martin; Rohde, Holger

    2011-01-01

    Assembly of adherent biofilms is the key mechanism involved in Staphylococcus epidermidis virulence during device-associated infections. Aside from polysaccharide intercellular adhesin (PIA), the accumulation-associated protein Aap and the extracellular matrix binding protein Embp act as intercellular adhesins, mediating S. epidermidis cell aggregation and biofilm accumulation. The aim of this study was to investigate structural features of PIA-, Aap-, and Embp-mediated S. epidermidis biofilms in more detail and to evaluate their specific contributions to biofilm-related S. epidermidis immune escape. PIA-, Embp-, and Aap-mediated biofilms exhibited substantial morphological differences. Basically, PIA synthesis induced formation of macroscopically visible, rough cell clusters, whereas Aap- and Embp-dependent biofilms preferentially displayed a smooth layer of aggregated bacteria. On the microscopic level, PIA was found to form a string-like organized extracellular matrix connecting the bacteria, while Embp produced small deposits of intercellular matrix and Aap was strictly localized to the bacterial surface. Despite marked differences, S. epidermidis strains using PIA, Aap, or Embp for biofilm formation were protected from uptake by J774A.1 macrophages, with similarly efficiencies. In addition, compared to biofilm-negative S. epidermidis strains, isogenic biofilm-forming S. epidermidis induced only a diminished inflammatory J774A.1 macrophage response, leading to significantly (88.2 to 88.7%) reduced NF-κB activation and 68.8 to 83% reduced interleukin-1β (IL-1β) production. Mechanical biofilm dispersal partially restored induction of NF-κB activation, although bacterial cell surfaces remained decorated with the respective intercellular adhesins. Our results demonstrate that distinct S. epidermidis biofilm morphotypes are similarly effective at protecting S. epidermidis from phagocytic uptake and at counteracting macrophage activation, providing novel insights

  12. NATO Glossary of Abbreviations Used in NATO Documents and Publications (glossaire otan des abreviations utilisees dans les documents et publications otan)

    Science.gov (United States)

    2010-01-01

    02] informatique [EAPC(NCSREPS)WP] Note : usage général et très courant. traitement automatique des données /TAD2/ [ADatP-02] ADP3 automatic... informatique [ADatP-02] ADR1 aerodrome damage repair [AAP-06] réparation des dégâts subis par un aérodrome [AAP-06] ADR2 air defence radar [NASG...AC/281-N(2009)0090] commandement, contrôle, communication et informatique [AC/281-N(2009)0090] CA1 civil affairs [C-M(2004)0001] affaires

  13. New insights into the tectonic evolution of the Andaman basin, northeast Indian Ocean

    Digital Repository Service at National Institute of Oceanography (India)

    KameshRaju, K.A.; Ramprasad, T.; Rao, P.S.; Rao, B.R.; Varghese, J.

    lines represent absence of magnetics, dashed lines AAP and BBP seismic re£ection data. EPSL 7024 25-3-04 Cyaan Magenta Geel Zwart K.A. Kamesh Raju et al./Earth and Planetary Science Letters 221 (2004) 145^162146 Andaman island arc including the Andaman... Zwart K.A. Kamesh Raju et al./Earth and Planetary Science Letters 221 (2004) 145^162 147 Fig. 2. Color-coded image of the sea£oor generated from the swath bathymetry data. The image is arti¢cially illuminated at an azimuth of 330‡N. Lines AAP and BBP...

  14. Amino Acid Permeases and Virulence in Cryptococcus neoformans.

    Directory of Open Access Journals (Sweden)

    Kevin Felipe Cruz Martho

    Full Text Available Fungal opportunistic pathogens colonize various environments, from plants and wood to human and animal tissue. Regarding human pathogens, one great challenge during contrasting niche occupation is the adaptation to different conditions, such as temperature, osmolarity, salinity, pressure, oxidative stress and nutritional availability, which may constitute sources of stress that need to be tolerated and overcome. As an opportunistic pathogen, C. neoformans faces exactly these situations during the transition from the environment to the human host, encountering nutritional constraints. Our previous and current research on amino acid biosynthetic pathways indicates that amino acid permeases are regulated by the presence of the amino acids, nitrogen and temperature. Saccharomyces cerevisiae and Candida albicans have twenty-four and twenty-seven genes encoding amino acid permeases, respectively; conversely, they are scarce in number in Basidiomycetes (C. neoformans, Coprinopsis cinerea and Ustilago maydis, where nine to ten permease genes can be found depending on the species. In this study, we have demonstrated that two amino acid permeases are essential for virulence in C. neoformans. Our data showed that C. neoformans uses two global and redundant amino acid permeases, Aap4 and Aap5 to respond correctly to thermal and oxidative stress. Double deletion of these permeases causes growth arrest in C. neoformans at 37°C and in the presence of hydrogen peroxide. The inability to uptake amino acid at a higher temperature and under oxidative stress also led to virulence attenuation in vivo. Our data showed that thermosensitivity caused by the lack of permeases Aap4 and Aap5 can be remedied by alkaline conditions (higher pH and salinity. Permeases Aap4 and Aap5 are also required during fluconazole stress and they are the target of the plant secondary metabolite eugenol, a potent antifungal inhibitor that targets amino acid permeases. In summary, our work

  15. A putative role for amino acid permeases in sink-source communication of barley tissues uncovered by RNA-seq

    Directory of Open Access Journals (Sweden)

    Kohl Stefan

    2012-08-01

    Full Text Available Abstract Background The majority of nitrogen accumulating in cereal grains originates from proteins remobilised from vegetative organs. However, interactions between grain filling and remobilisation are poorly understood. We used transcriptome large-scale pyrosequencing of flag leaves, glumes and developing grains to identify cysteine peptidase and N transporter genes playing a role in remobilisation and accumulation of nitrogen in barley. Results Combination of already known and newly derived sequence information reduced redundancy, increased contig length and identified new members of cysteine peptidase and N transporter gene families. The dataset for N transporter genes was aligned with N transporter amino acid sequences of rice and Arabidopsis derived from Aramemnon database. 57 AAT, 45 NRT1/PTR and 22 OPT unigenes identified by this approach cluster to defined subgroups in the respective phylogenetic trees, among them 25 AAT, 8 NRT1/PTR and 5 OPT full-length sequences. Besides, 59 unigenes encoding cysteine peptidases were identified and subdivided into different families of the papain cysteine peptidase clade. Expression profiling of full-length AAT genes highlighted amino acid permeases as the group showing highest transcriptional activity. HvAAP2 and HvAAP6 are highly expressed in vegetative organs whereas HvAAP3 is grain-specific. Sequence similarities cluster HvAAP2 and the putative transporter HvAAP6 together with Arabidopsis transporters, which are involved in long-distance transfer of amino acids. HvAAP3 is closely related to AtAAP1 and AtAAP8 playing a role in supplying N to developing seeds. An important role in amino acid re-translocation can be considered for HvLHT1 and HvLHT2 which are specifically expressed in glumes and flag leaves, respectively. PCA and K-means clustering of AAT transcript data revealed coordinate developmental stages in flag leaves, glumes and grains. Phloem-specific metabolic compounds are proposed that

  16. Fluorescence excitation spectrum and solvent-assisted conformational isomerization (SACI) of jet-cooled acetaminophen

    Science.gov (United States)

    Sohn, Woon Yong; Kang, Jeong Seok; Lee, So Young; Kang, Hyuk

    2013-08-01

    Fluorescence excitation spectrum of jet-cooled acetaminophen was obtained. When AAP was expanded with a buffer gas containing 0.3-1.1% of water, absorption peaks of the less stable trans conformer was significantly reduced by solvent-assisted conformational isomerization (SACI), which is confirmed by a separately measured UV-UV hole burning spectroscopy. It is also confirmed by quantum mechanical calculation and RRKM calculation that it is energetically and kinetically possible to induce SACI in AAP with water. The SACI mechanism suggests a possible pathway that acetaminophen can adopt an active conformation in vivo, which is need for molecular recognition and drug activity.

  17. Use of a FITLINE to Support Families of Overweight and Obese Children in Pediatric Practices.

    Science.gov (United States)

    Pbert, Lori; Druker, Susan; Barton, Bruce; Olendzki, Barbara; Andersen, Victoria; Persuitte, Gioia; Bram, Jennifer; Kurtz, Stephen; Powers, E Michael; Crawford, Sybil; Geller, Alan C

    2016-02-01

    The American Academy of Pediatrics (AAP) recommends a staged approach to pediatric weight management, starting with helping families to make targeted dietary and activity changes. This pilot study evaluated the preliminary efficacy of a pediatric practice-based referral program to support parents in helping their overweight/obese children improve their weight-related behaviors and BMI. A nonrandomized intervention study with contemporaneous control was used. Parents and their children ages 8-12 with BMI ≥85th percentile (N = 37) were recruited from a pediatric practice serving a low-income, multiethnic population. Providers delivered brief intervention and referred families to six weekly FITLINE telephone counseling sessions with a nutritionist who guided parents in helping their child make AAP-recommended changes. Child BMI and parent survey of child diet and physical activity were completed at baseline and 3 months. Medical record data from 44 children matched for age and BMI were collected. Mean change in BMI from baseline to 3-month follow-up was -0.49 BMI units (standard deviation [SD], 0.95; p = 0.007) for the FITLINE group and 0.35 BMI units (SD, 0.96; p = 0.02) for the control group. Adjusting for baseline BMI, age, and sex, children in the FITLINE condition reduced BMI significantly more than children in the control condition (mean difference = -0.89; p = 0.0003). Significant improvements in many dietary and sedentary behaviors also were noted. The FITLINE program reduced short-term BMI and improved dietary and sedentary behaviors. A randomized, controlled trial is warranted to assess the program's efficacy and potential to serve as a model for reducing obesity in pediatric practice.

  18. Oral health content of early education and child care regulations and standards.

    Science.gov (United States)

    Kranz, Ashley M; Rozier, R Gary

    2011-01-01

    Almost two out of every three US children younger than five receive child care from someone other than their parents. Health promotion in early education and child care (EECC) programs can improve the general health of children and families, but little is known about the role of these programs in oral health. We identified U.S. EECC program guidelines and assessed their oral health recommendations for infants and toddlers. State licensing regulations were obtained from the National Resource Center for Health and Safety in Child Care's online database. Professional standards were identified through a search of PubMed, early childhood organizations' websites, and early childhood literature. All EECC guidelines were reviewed for key terms related to oral health promotion in children and summarized by domains. Thirty-six states include oral health in their licensing regulations, but recommendations are limited and most often address the storage of toothbrushes. Eleven sets of standards were identified, four of which make recommendations about oral health. Standards from the American Academy of Pediatrics/American Public Health Association (AAP/APHA) and the Office of Head Start (OHS) provide the most comprehensive oral health recommendations regarding screening and referral, classroom activities, and education. Detailed guidelines for oral health practices exist but they exhibit large variation in number and content. States can use the comprehensive standards from the AAP/APHA and OHS to inform and strengthen the oral health content of their licensing regulations. Research is needed to determine compliance with regulations and standards, and their effect on oral health.

  19. Summer Safety Tips - Staying Safe Outdoors

    Science.gov (United States)

    ... following these tips from the American Academy of Pediatrics (AAP). Also, see Summer Safety Tips: Sun and Water Safety ​ for more information. Fireworks Safety​​ Fireworks can result in severe burns , blindness, scars, and even death. Fireworks that are ...

  20. Browse Title Index

    African Journals Online (AJOL)

    Items 1 - 50 of 63 ... Issue, Title. Vol 7, No 2 (2002), AAPS, African Political Science and Globalisation: Which Way Forward? Abstract. L. Adele Jinadu. Vol 6, No 1 (2001), African Crisis Response Initiative and the New African Security (Dis)order, Abstract. Emmanuel K. Aning. Vol 5, No 1 (2000), African Renaissance in the New ...

  1. Delayed and successful manual removal of abnormally adherent ...

    African Journals Online (AJOL)

    myomectomy, hysteroscopic surgery and uterine artery embolisation. – curiously, our patient had none of these. Despite the risk factors being well established, the underlying cause of AAP is not fully understood. Current aetiological concepts include abnormal decidualisation (with an absent normal plane of cleavage above.

  2. Infection and inflammatory mechanisms

    NARCIS (Netherlands)

    Van Dyke, Thomas E.; van Winkelhoff, Arie Jan

    This introductory article examines the potential mechanisms that may play a role in the associations between periodontitis and the systemic conditions being considered in the EFP/AAP Workshop in Segovia, Spain. Three basic mechanisms have been postulated to play a role in these interactions;

  3. Asparaginase-associated pancreatitis in children with acute lymphoblastic leukaemia in the NOPHO ALL2008 protocol

    DEFF Research Database (Denmark)

    Raja, Raheel A; Schmiegelow, Kjeld; Albertsen, Birgitte K

    2014-01-01

    within an asparaginase-intensive protocol has been poorly reported. Children (1-17 years) on the ongoing Nordic Society of Paediatric Haematology and Oncology (NOPHO) ALL2008 protocol with asparaginase-associated pancreatitis (AAP) diagnosed between 2008 and 2012 were identified through the online NOPHO...

  4. Demonstration of Electro-Osmotic Pulse Technology for Groundwater Intrusion Control in Concrete Structures.

    Science.gov (United States)

    1998-04-01

    humidity and mold problems. This study demonstrated and document the effectiveness of EOP technology to control groundwater intrusion in concrete ... structures at Fort Jackson, SC and McAlester Army Ammunition Plant (AAP), OK. The cost of installation was determined to be 40 percent lower than the cost of

  5. The effect of amyloid associated proteins on the expression of genes involved in amyloid-beta clearance by adult human astrocytes

    NARCIS (Netherlands)

    Mulder, S.D.; Veerhuis, R.; Blankenstein, M.A.; Nielsen, H.M.

    2012-01-01

    Astrocytes appear to be important mediators in the clearance of amyloid beta1-42 (Aβ), the key component of senile plaques characteristic of Alzheimer's disease (AD). Recently, we found the amyloid associated proteins (AAPs) α1-antichymotrypsin (ACT), apolipoprotein J and E (ApoJ and ApoE) and a

  6. NCBI nr-aa BLAST: CBRC-MDOM-05-0629 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MDOM-05-0629 ref|YP_025950.1| NADH dehydrogenase subunit 2 [Strigops habroptil...us] gb|AAP47794.1| NADH dehydrogenase subunit 2 [Strigops habroptilus] YP_025950.1 0.28 24% ...

  7. ORF Alignment: NC_002940 [GENIUS II[Archive

    Lifescience Database Archive (English)

    Full Text Available NC_002940 gi|33151562 >1u07A 8 84 201 279 1e-08 ... gb|AAP95304.1| TobB energy transd...ucing protein [Haemophilus ducreyi 35000HP] ... ref|NP_872915.1| TobB energy transducing protein ...

  8. 421-IJBCS-Article-Dr Renu Chadha

    African Journals Online (AJOL)

    DR GATSING

    229. Chowdhary KPR, Rao YS. 2003. Design and in-vitro and in-vivo evaluation of mucoadhesive microcapsules of glipizide for oral controlled release: A technical note. AAPS Pharm. Sci. Tech., 4: 1-6. Chowdhary KPR, Rao NK, Malathi K. 2004. Ethyl cellulose microspheres of glipizide: Characterization, in vitro and in vivo.

  9. St. John's Wort

    Science.gov (United States)

    ... Dietary Supplements. 2nd ed. New York, NY: Informa Healthcare; 2010:727-737. Borrelli F, Izzo AA. Herb-drug interactions with St. John’s wort (Hypericum perforatum) : an update on clinical observations . The AAPS Journal. 2009;11(4):2009;11(4):710-727. ...

  10. NCBI nr-aa BLAST: CBRC-AGAM-01-0042 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-AGAM-01-0042 ref|NP_860134.1| type IV prepilin peptidase HopD [Helicobacter he...paticus ATCC 51449] gb|AAP77200.1| type IV prepilin peptidase HopD [Helicobacter hepaticus ATCC 51449] NP_860134.1 0.15 26% ...

  11. ORF Alignment: NC_004722 [GENIUS II[Archive

    Lifescience Database Archive (English)

    Full Text Available NC_004722 gi|30022646 >1y0yA 3 348 9 357 e-103 ... ref|NP_834277.1| Deblocking aminop...eptidase [Bacillus cereus ATCC 14579] ... gb|AAP11478.1| Deblocking aminopeptidase [Bacillus ...

  12. ORF Alignment: NC_004722 [GENIUS II[Archive

    Lifescience Database Archive (English)

    Full Text Available NC_004722 gi|30022768 >1y0yA 3 341 5 343 3e-99 ... ref|NP_834399.1| Deblocking aminop...eptidase [Bacillus cereus ATCC 14579] ... gb|AAP11600.1| Deblocking aminopeptidase [Bacillus ...

  13. ORF Alignment: NC_004722 [GENIUS II[Archive

    Lifescience Database Archive (English)

    Full Text Available NC_004722 gi|30019056 >1y0yA 3 340 8 342 3e-72 ... ref|NP_830687.1| Deblocking aminop...eptidase [Bacillus cereus ATCC 14579] ... gb|AAP07888.1| Deblocking aminopeptidase [Bacillus ...

  14. NCBI nr-aa BLAST: CBRC-PVAM-01-0362 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-PVAM-01-0362 gb|AAP36781.1| Homo sapiens vasoactive intestinal peptide recepto...r 2 [synthetic construct] gb|AAX43622.1| vasoactive intestinal peptide receptor 2 [synthetic construct] gb|AAX43623.1| va

  15. NCBI nr-aa BLAST: CBRC-PVAM-01-1300 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-PVAM-01-1300 ref|NP_001136269.1| chemokine (C-X-C motif) receptor 3 isoform B ... gb|AAP55851.1|AF469635_1 CXC chemokine receptor transcript variant B [Homo sapiens] dbj|BAG74000.1| chemoki

  16. Studying the role of vision in cycling : critique on restricting research to fixation behaviour.

    NARCIS (Netherlands)

    Schepers, J.P. Brinker, B.P.L.M. den Waard, D. de Twisk, D.A.M. Schwab, D.A.M. & Smeets, J.B.J.

    2013-01-01

    In a recent study published in Accident Analysis & Prevention, Vansteenkiste et al. (2013, http://dx.doi.org/10.1016/j.aap.2012.11.025) – as one of the first in this field – investigated the visual control of bicycle steering. They undertook the interesting task of testing cyclists’ eye fixation

  17. "Ma ei ole Soprano!" / Mihkel Kärmas

    Index Scriptorium Estoniae

    Kärmas, Mihkel, 1974-

    2002-01-01

    Ilmunud ka: Estonija Mar/18 lk. 5. Kümme aastat Tallinna Keskkonnaametit juhtinud Aap Mumme tõi Eestisse Euroopa suurima jäätmekäitlusfirma SKP. Pärast riigitöölt lahkumist sai temast sama firma palgaline ja partner

  18. Surveying Turkish High School and University Students' Attitudes and Approaches to Physics Problem Solving

    Science.gov (United States)

    Balta, Nuri; Mason, Andrew J.; Singh, Chandralekha

    2016-01-01

    Students' attitudes and approaches to physics problem solving can impact how well they learn physics and how successful they are in solving physics problems. Prior research in the U.S. using a validated Attitude and Approaches to Problem Solving (AAPS) survey suggests that there are major differences between students in introductory physics and…

  19. NCBI nr-aa BLAST: CBRC-DNOV-01-1344 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-DNOV-01-1344 ref|YP_223898.1| putative tape measure protein [Lactobacillus pha...ge phiJL-1] gb|AAP74525.1| putative tape measure protein [Lactobacillus plantarum bacteriophage phiJL-1] YP_223898.1 0.015 22% ...

  20. 42 CFR 457.520 - Cost sharing for well-baby and well-child care services.

    Science.gov (United States)

    2010-10-01

    ... examinations as recommended and updated by the American Academy of Pediatrics (AAP) “Guidelines for Health... 42 Public Health 4 2010-10-01 2010-10-01 false Cost sharing for well-baby and well-child care services. 457.520 Section 457.520 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF...

  1. Enhancing pediatric workforce diversity and providing culturally effective pediatric care: implications for practice, education, and policy making.

    Science.gov (United States)

    2013-10-01

    This policy statement serves to combine and update 2 previously independent but overlapping statements from the American Academy of Pediatrics (AAP) on culturally effective health care (CEHC) and workforce diversity. The AAP has long recognized that with the ever-increasing diversity of the pediatric population in the United States, the health of all children depends on the ability of all pediatricians to practice culturally effective care. CEHC can be defined as the delivery of care within the context of appropriate physician knowledge, understanding, and appreciation of all cultural distinctions, leading to optimal health outcomes. The AAP believes that CEHC is a critical social value and that the knowledge and skills necessary for providing CEHC can be taught and acquired through focused curricula across the spectrum of lifelong learning. This statement also addresses workforce diversity, health disparities, and affirmative action. The discussion of diversity is broadened to include not only race, ethnicity, and language but also cultural attributes such as gender, religious beliefs, sexual orientation, and disability, which may affect the quality of health care. The AAP believes that efforts must be supported through health policy and advocacy initiatives to promote the delivery of CEHC and to overcome educational, organizational, and other barriers to improving workforce diversity.

  2. Eesti paviljon "Koda" = Estonian pavilion "Koda"

    Index Scriptorium Estoniae

    2015-01-01

    Eesti paviljon "Koda" Hollandi maailmanäitusel "Floriade". Arhitektuurivõistlus 2011. Arhitektid Joel Kopli, Koit Ojaliiv (Kuu Arhitektid), konstruktorid Alar Hammer, Marek Suursalu (Projekt 363). Lauad Kristel Jakobson (Haka Disain), toolid Aap Piho (Maast Furniture), valgustid Margus Triibmann (Keha3)

  3. NCBI nr-aa BLAST: CBRC-DDIS-04-0058 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-DDIS-04-0058 ref|NP_859977.1| hypothetical protein HH0446 [Helicobacter hepati...cus ATCC 51449] gb|AAP77043.1| conserved hypothetical protein [Helicobacter hepaticus ATCC 51449] NP_859977.1 1e-10 28% ...

  4. NCBI nr-aa BLAST: CBRC-BTAU-01-1813 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-BTAU-01-1813 ref|NP_852880.1| hypothetical protein MGA_0800 [Mycoplasma galliseptic...um R] gb|AAP56448.1| unique hypothetical protein [Mycoplasma gallisepticum R] NP_852880.1 0.39 21% ...

  5. NCBI nr-aa BLAST: CBRC-DDIS-02-0086 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-DDIS-02-0086 ref|NP_853044.1| hypothetical protein MGA_1103 [Mycoplasma galliseptic...um R] gb|AAP56612.1| conserved hypothetical protein [Mycoplasma gallisepticum R] NP_853044.1 0.003 24% ...

  6. NCBI nr-aa BLAST: CBRC-LAFR-01-0231 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-LAFR-01-0231 ref|NP_852970.1| hypothetical protein MGA_0954 [Mycoplasma galliseptic...um R] gb|AAP56538.1| conserved hypothetical protein [Mycoplasma gallisepticum R] NP_852970.1 0.033 23% ...

  7. NCBI nr-aa BLAST: CBRC-ATHA-05-0017 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-ATHA-05-0017 ref|NP_852878.1| hypothetical protein MGA_0797 [Mycoplasma galliseptic...um R] gb|AAP56446.1| unique hypothetical protein [Mycoplasma gallisepticum R] NP_852878.1 0.43 26% ...

  8. NCBI nr-aa BLAST: CBRC-DNOV-01-0787 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-DNOV-01-0787 ref|NP_853432.1| hypothetical protein MGA_0477 [Mycoplasma galliseptic...um R] gb|AAP57000.1| unique hypothetical protein [Mycoplasma gallisepticum R] NP_853432.1 0.047 27% ...

  9. NCBI nr-aa BLAST: CBRC-DNOV-01-0511 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-DNOV-01-0511 ref|NP_852884.1| hypothetical protein MGA_0805 [Mycoplasma galliseptic...um R] gb|AAP56452.1| conserved hypothetical protein [Mycoplasma gallisepticum R] NP_852884.1 0.73 23% ...

  10. NCBI nr-aa BLAST: CBRC-DDIS-02-0111 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-DDIS-02-0111 ref|NP_853044.1| hypothetical protein MGA_1103 [Mycoplasma galliseptic...um R] gb|AAP56612.1| conserved hypothetical protein [Mycoplasma gallisepticum R] NP_853044.1 0.003 24% ...

  11. NCBI nr-aa BLAST: CBRC-ACAR-01-0122 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-ACAR-01-0122 gb|AAP36136.1| Homo sapiens cholinergic receptor, muscarinic 1 [s...ynthetic construct] gb|AAX29286.1| cholinergic receptor muscarinic 1 [synthetic construct] gb|AAX29287.1| choliner

  12. Assessing Attachment Representations in Adolescents: Discriminant Validation of the Adult Attachment Projective Picture System.

    Science.gov (United States)

    Gander, Manuela; George, Carol; Pokorny, Dan; Buchheim, Anna

    2017-04-01

    The contribution of attachment to human development and clinical risk is well established for children and adults, yet there is relatively limited knowledge about attachment in adolescence due to the poor availability of construct valid measures. The Adult Attachment Projective Picture System (AAP) is a reliable and valid instrument to assess adult attachment status. This study examines for the first time the discriminant validity of the AAP in adolescents. In our sample of 79 teenagers between 15 and 18 years, 42 % were classified as secure, 34 % as insecure-dismissing, 13 % as insecure-preoccupied and 11 % as unresolved. The results demonstrated discriminant validity for using the AAP in that age group, with no associations between attachment classifications and verbal intelligence, social desirability, story length or sociodemographic variables. These results poise the AAP to be used in clinical intervention and large-scale research investigating normative and atypical developmental correlates and sequelae of attachment, including psychopathology in adolescence.

  13. NCBI nr-aa BLAST: CBRC-GACU-17-0011 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-GACU-17-0011 ref|NP_989793.1| potassium voltage-gated channel, shaker-related ...subfamily, member 10 [Gallus gallus] gb|AAP94024.1| shaker subfamily potassium channel KCNA10 [Gallus gallus] NP_989793.1 0.0 68% ...

  14. Women Physicians Are Underrepresented in Recognition Awards From the Association of Academic Physiatrists.

    Science.gov (United States)

    Silver, Julie K; Blauwet, Cheri A; Bhatnagar, Saurabha; Slocum, Chloe S; Tenforde, Adam S; Schneider, Jeffrey C; Zafonte, Ross D; Goldstein, Richard; Gallegos-Kearin, Vanessa; Reilly, Julia M; Mazwi, Nicole L

    2018-01-01

    Determine representation by gender for individual recognition awards presented to physicians by the Association of Academic Physiatrists (AAP). Cross-sectional survey was used. Lists of individual recognition award recipients for the 27-yr history of the AAP awards (1990-2016) were analyzed. The primary outcome measures were the total numbers of men versus women physician award recipients overall and for the past decade (2007-2016). No awards were given to women physicians for the past 4 yrs (2013-2016) or in half of the award categories for the past decade (2007-2016). No woman received the outstanding resident/fellow award since its inception (2010-2016). There was a decrease in the proportion of awards given to women in the past decade (2007-2016, 7 of 39 awards, 17.9%) as compared with the first 17 yrs (1990-2006, 10 of 46 awards, 21.7%). Furthermore, compared with their proportional membership within the specialty, women physicians were underrepresented for the entire 27-yr history of the AAP awards (1990-2016, 17 of 85 awards, 20%). According to the Association of American Medical Colleges, the proportion of full-time female physical medicine and rehabilitation faculty members was 38% in 1992 and 41% in 2013. Women physicians have been underrepresented by the AAP in recognition awards. Although the reasons are not clear, these findings should be further investigated.

  15. 77 FR 62512 - Radio Broadcasting Services; AM or FM Proposals To Change the Community of License.

    Science.gov (United States)

    2012-10-15

    ... COMMISSION Radio Broadcasting Services; AM or FM Proposals To Change the Community of License. AGENCY... BROADCASTING ASSOCIATION, Station KLXM, Facility ID 184961, BMPED-20120823AAP, From WEATHERFORD, OK, To ARAPAHO, OK; COMMUNITY RADIO PROJECT, Station KZET, Facility ID 173810, BPED-20120914AEF, From CORTEZ, CO, To...

  16. 41 CFR 60-1.20 - Compliance evaluations.

    Science.gov (United States)

    2010-07-01

    ... otherwise treated during employment without regard to race, color, religion, sex, or national origin. A... regulatory obligations not required to be included in the AAP, and to examine potential instances or issues... be conducted where issues have arisen concerning deficiencies or an apparent violation which, in the...

  17. Influence of the surface structure on the filtration performance of UV-modified PES membranes

    DEFF Research Database (Denmark)

    Kæselev, Bozena Alicja; Kingshott, P.; Jonsson, Gunnar Eigil

    2002-01-01

    Poly (ether sulfone) (PES) 50 kDa membranes were surface modified by irradiation with UV light (254 nm) in the presence of N-vinyl-2-pyrrolidine (NVP), 2-acrylamidoglycolic acid monohydrate (AAG) and 2-acrylamido-2-methyl-1-propanesulfonic acid (AAP). The surfaces of the modified membranes were c...

  18. Animal-assisted dyadic therapy: A therapy model promoting development of the reflective function in the parent-child bond.

    Science.gov (United States)

    Shani, Liat

    2017-01-01

    Animal-assisted psychotherapy (AAP) inherently incorporates standpoints, interventions, and ways of action promoting the development of the reflective function and mentalization, and thus has special value for parent-child psychotherapy. Two central tools in AAP contribute to this process. The first is the ethical stance of the therapist, who sees the animals as full partners in the therapy situation, respecting them as subjects with needs, desires, and thoughts of their own. The second tool combines nonverbal communication with animals together with the relating, in the here and now, to the understanding and decoding of body language of everyone in the setting. Nonverbal communication in AAP enables access to implicit communication patterns occurring between parent and child. This article provides a survey of theoretical development and research constituting a basis for the development of therapeutic approaches for the improvement of parent-children dynamics, followed by a description of a dyadic therapy model of a mentalization-based treatment originating from a psychoanalytic-relational orientation. Clinical examples are provided to illustrate AAP processes in parent-child psychotherapy (consent was received for examples that were not aggregated).

  19. Characterization of Celecoxib-Loaded Solid Lipid Nanoparticles ...

    African Journals Online (AJOL)

    of solid lipid Nanoparticles (SLN) made of cacao butter and curdlan. Eur J Pharm Sci 2005; 24: 199-. 205. 19. Reddy LH, Murthy RS. Etoposide-loaded nanoparticles made from glyceride lipids: formulation, characterization, in vitro drug release, and stability evaluation. AAPS PharmSciTech 2005; 6(2): E158–. E166. 20.

  20. ORF Alignment: NC_004722 [GENIUS II[Archive

    Lifescience Database Archive (English)

    Full Text Available NC_004722 gi|30020738 >1mr7A 1 202 9 210 2e-65 ... ref|NP_832369.1| Virginiamycin A a...cetyltransferase [Bacillus cereus ATCC 14579] ... gb|AAP09570.1| Virginiamycin A acetyltransferase ...

  1. NCBI nr-aa BLAST: CBRC-TTRU-01-1120 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-TTRU-01-1120 sp|Q86UP3|ZFHX4_HUMAN RecName: Full=Zinc finger homeobox protein ...4; AltName: Full=Zinc finger homeodomain protein 4; Short=ZFH-4 gb|AAP20225.1| zinc finger homeodomain 4 protein [Homo sapiens] Q86UP3 0.0 87% ...

  2. NCBI nr-aa BLAST: CBRC-PVAM-01-1002 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-PVAM-01-1002 sp|Q86UP3|ZFHX4_HUMAN RecName: Full=Zinc finger homeobox protein ...4; AltName: Full=Zinc finger homeodomain protein 4; Short=ZFH-4 gb|AAP20225.1| zinc finger homeodomain 4 protein [Homo sapiens] Q86UP3 0.0 86% ...

  3. NCBI nr-aa BLAST: CBRC-MDOM-03-0052 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MDOM-03-0052 sp|Q86UP3|ZFHX4_HUMAN RecName: Full=Zinc finger homeobox protein ...4; AltName: Full=Zinc finger homeodomain protein 4; Short=ZFH-4 gb|AAP20225.1| zinc finger homeodomain 4 protein [Homo sapiens] Q86UP3 0.0 91% ...

  4. Gene : CBRC-DNOV-01-1344 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-DNOV-01-1344 Novel UN B UNKNOWN THI74_YEAST 0.098 24% ref|YP_223898.1| putative tape measure... protein [Lactobacillus phage phiJL-1] gb|AAP74525.1| putative tape measure protein [Lactobaci

  5. Asymmetric dimethylarginine in somatically healthy schizophrenia patients treated with atypical antipsychotics

    DEFF Research Database (Denmark)

    Jørgensen, Anders; Knorr, Ulla Benedichte Søsted; Soendergaard, Mia Greisen

    2015-01-01

    ratio are positively correlated to measures of oxidative stress. METHODS: We included 40 schizophrenia patients treated with AAP, but without somatic disease or drug abuse, and 40 healthy controls. Plasma concentrations of ADMA and L-arginine were determined by high-performance liquid chromatography...

  6. Impact of FDA Black Box Warning on Psychotropic Drug Use in Noninstitutionalized Elderly Patients Diagnosed With Dementia: A Retrospective Study.

    Science.gov (United States)

    Singh, Rakesh R; Nayak, Rajesh

    2016-10-01

    The study seeks to investigate the impact of Food and Drug Administration's black box warning (BBW) on the use of atypical antipsychotics (AAP) and nonantipsychotic psychotropic alternatives in noninstitutionalized elderly population diagnosed with dementia. The Medical Expenditure Panel Survey (2004 through 2007) was utilized as the data source. Medication use in elderly patients (≥65 years) was defined as taking at least 1 medication for dementia. We performed a statistical comparison of prewarning (2004-2005) and postwarning (2006-2007) periods with respect to AAP and nonantipsychotic psychotropic use to examine the impact of labeling changes. A bivariate analysis did not yield statistically significant change in either the AAP or nonantipsychotic psychotropic use, pre- versus postwarning. However, multivariate logistic-regression analyses revealed greater odds for antidementia (odds ratio [OR] = 1.976, P = .0195) and benzodiazepine (OR = 3.046, P = .0227) medication use in postwarning period compared to the prewarning period. The regulatory warnings and labeling changes regarding off-label use of AAPs in dementia treatment showed minimal impact on their actual use in noninstitutionalized populations. A corresponding increase in the use of nonantipsychotic psychotropics explains that BBW might have resulted in a compensatory shift in favor of benzodiazepines and antidementia medications. Additional research should be conducted to examine the long-term impact of BBW on antipsychotic prescribing changes. © The Author(s) 2015.

  7. NCBI nr-aa BLAST: CBRC-DNOV-01-2484 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-DNOV-01-2484 ref|YP_006355.1| ATP synthase F0 subunit 6 [Siphonodentalium loba...tum] gb|AAP91676.1| ATP synthase F0 subunit 6 [Siphonodentalium lobatum] YP_006355.1 5e-04 29% ...

  8. Motivational Style and Actual and Perceived Academic Performance of Secondary School Students in Hong Kong

    Science.gov (United States)

    Sit, Cindy H. P.; Braman, O. Randall; Kerr, John H.; Lindner, Koenraad J.

    2013-01-01

    This study examined the relationship between motivational style and academic achievement among 2,220 secondary school males and females in Hong Kong. Respondents were classified into high, average, or low academic performance (AAP) groups based on a single average for academic subjects obtained from their schools. Respondents were also classified…

  9. NCBI nr-aa BLAST: CBRC-PVAM-01-1470 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-PVAM-01-1470 sp|Q86UP3|ZFHX4_HUMAN RecName: Full=Zinc finger homeobox protein ...4; AltName: Full=Zinc finger homeodomain protein 4; Short=ZFH-4 gb|AAP20225.1| zinc finger homeodomain 4 protein [Homo sapiens] Q86UP3 0.0 91% ...

  10. NCBI nr-aa BLAST: CBRC-MEUG-01-1719 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MEUG-01-1719 sp|Q86UP3|ZFHX4_HUMAN RecName: Full=Zinc finger homeobox protein ...4; AltName: Full=Zinc finger homeodomain protein 4; Short=ZFH-4 gb|AAP20225.1| zinc finger homeodomain 4 protein [Homo sapiens] Q86UP3 0.0 94% ...

  11. Development and Evaluation of Controlled-Release Bilayer Tablets ...

    African Journals Online (AJOL)

    Purpose: To develop and characterize bilayer tablet formulations of tramadol HCl (TmH) and acetaminophen (AAP) microparticles. Methods: Coacervation via temperature change was the encapsulated method used for the preparation of the microparticles, with ethyl cellulose (EC) of medium viscosity as the polymer for ...

  12. NCBI nr-aa BLAST: CBRC-XTRO-01-1252 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-XTRO-01-1252 ref|NP_833085.1| Collagen-like triple helix repeat protein [Bacil...lus cereus ATCC 14579] gb|AAP10286.1| Collagen-like triple helix repeat protein [Bacillus cereus ATCC 14579] NP_833085.1 2e-45 36% ...

  13. Vitamin D in Health and Disease in Adolescents: When to Screen, Whom to Treat, and How to Treat.

    Science.gov (United States)

    Golden, Neville H; Carey, Dennis E

    2016-01-01

    The existing guidelines on screening and treatment are confusing because different guidelines target different populations. The IOM and AAP guidelines target generally healthy populations, whereas the Endocrine Society and other subspecialty guidelines target individuals with specific medical conditions associated with increased bone fragility. These distinctions have not always been well articulated. For healthy adolescents, the AAP does not recommend universal screening or screening of obese or dark-skinned individuals. Increased dietary intake of vitamin D is recommended, and vitamin D supplementation can be considered if the RDA cannot be met. For adolescents with chronic medical illnesses associated with increased fracture risk, screening for vitamin D deficiency should be performed by obtaining a serum 25-OHD level. Those found to be deficient (25-OHD level vitamin D2 or vitamin D3 higher than the daily requirement (as discussed in the section on vitamin D and chronic disease), followed by a maintenance dose. A repeat 25-OHD level should be obtained after the therapeutic course is completed. Some experts advocate for achievement of 25-OHD levels greater than 30 ng/mL in conditions associated with increased bone fragility, and several pediatric subspecialty organizations have made recommendations specific to the diseases they treat. In such instances, the recommendations of the pediatric subspecialty organizations should take precedence over the AAP recommendations for adolescents with chronic illnesses associated with increased bone fragility because the AAP recommendations were primarily targeted at a healthy population.

  14. Development and In vitro Evaluation of Self-Adhesive Matrix-Type ...

    African Journals Online (AJOL)

    Gondaliya D, Pundarikakshudu K. Studies in formulation and pharmacotechnical evaluation of controlled release transdermal delivery system of bupropion. AAPS PharmSciTech 2003; 4(1): 18-26. 22. Ganju K, Kondalkar A, Pathak AK. Formulation and evaluation of transdermal patch of colchicines with release modifiers.

  15. NCBI nr-aa BLAST: CBRC-GACU-17-0012 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-GACU-17-0012 ref|NP_001025549.1| potassium voltage-gated channel, shaker-relat...ed subfamily, member 3 [Gallus gallus] gb|AAP94028.1| shaker subfamily potassium channel Kv1.3 [Gallus gallus] NP_001025549.1 0.0 74% ...

  16. NCBI nr-aa BLAST: CBRC-TGUT-29-0000 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-TGUT-29-0000 ref|NP_001025549.1| potassium voltage-gated channel, shaker-relat...ed subfamily, member 3 [Gallus gallus] gb|AAP94028.1| shaker subfamily potassium channel Kv1.3 [Gallus gallus] NP_001025549.1 0.0 98% ...

  17. NCBI nr-aa BLAST: CBRC-FRUB-02-0329 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-FRUB-02-0329 ref|NP_989793.1| potassium voltage-gated channel, shaker-related ...subfamily, member 10 [Gallus gallus] gb|AAP94024.1| shaker subfamily potassium channel KCNA10 [Gallus gallus] NP_989793.1 0.0 71% ...

  18. NCBI nr-aa BLAST: CBRC-DRER-26-0215 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-DRER-26-0215 ref|NP_001025549.1| potassium voltage-gated channel, shaker-relat...ed subfamily, member 3 [Gallus gallus] gb|AAP94028.1| shaker subfamily potassium channel Kv1.3 [Gallus gallus] NP_001025549.1 0.0 74% ...

  19. NCBI nr-aa BLAST: CBRC-FRUB-02-0328 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-FRUB-02-0328 ref|NP_001025549.1| potassium voltage-gated channel, shaker-relat...ed subfamily, member 3 [Gallus gallus] gb|AAP94028.1| shaker subfamily potassium channel Kv1.3 [Gallus gallus] NP_001025549.1 0.0 84% ...

  20. NCBI nr-aa BLAST: CBRC-DRER-06-0073 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-DRER-06-0073 ref|NP_001025549.1| potassium voltage-gated channel, shaker-relat...ed subfamily, member 3 [Gallus gallus] gb|AAP94028.1| shaker subfamily potassium channel Kv1.3 [Gallus gallus] NP_001025549.1 0.0 74% ...

  1. NCBI nr-aa BLAST: CBRC-XTRO-01-2371 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-XTRO-01-2371 ref|NP_001025549.1| potassium voltage-gated channel, shaker-relat...ed subfamily, member 3 [Gallus gallus] gb|AAP94028.1| shaker subfamily potassium channel Kv1.3 [Gallus gallus] NP_001025549.1 0.0 78% ...

  2. NCBI nr-aa BLAST: CBRC-OLAT-07-0019 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-OLAT-07-0019 ref|NP_989793.1| potassium voltage-gated channel, shaker-related ...subfamily, member 10 [Gallus gallus] gb|AAP94024.1| shaker subfamily potassium channel KCNA10 [Gallus gallus] NP_989793.1 0.0 72% ...

  3. NCBI nr-aa BLAST: CBRC-OLAT-07-0020 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-OLAT-07-0020 ref|NP_001025549.1| potassium voltage-gated channel, shaker-relat...ed subfamily, member 3 [Gallus gallus] gb|AAP94028.1| shaker subfamily potassium channel Kv1.3 [Gallus gallus] NP_001025549.1 0.0 76% ...

  4. NCBI nr-aa BLAST: CBRC-CPOR-01-0502 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-CPOR-01-0502 ref|NP_989793.1| potassium voltage-gated channel, shaker-related ...subfamily, member 10 [Gallus gallus] gb|AAP94024.1| shaker subfamily potassium channel KCNA10 [Gallus gallus] NP_989793.1 0.0 78% ...

  5. NCBI nr-aa BLAST: CBRC-ACAR-01-1044 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-ACAR-01-1044 ref|NP_001025549.1| potassium voltage-gated channel, shaker-relat...ed subfamily, member 3 [Gallus gallus] gb|AAP94028.1| shaker subfamily potassium channel Kv1.3 [Gallus gallus] NP_001025549.1 0.0 90% ...

  6. NCBI nr-aa BLAST: CBRC-OLAT-26-0139 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-OLAT-26-0139 ref|NP_001025549.1| potassium voltage-gated channel, shaker-relat...ed subfamily, member 3 [Gallus gallus] gb|AAP94028.1| shaker subfamily potassium channel Kv1.3 [Gallus gallus] NP_001025549.1 0.0 81% ...

  7. NCBI nr-aa BLAST: CBRC-TNIG-09-0017 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-TNIG-09-0017 ref|NP_001025549.1| potassium voltage-gated channel, shaker-relat...ed subfamily, member 3 [Gallus gallus] gb|AAP94028.1| shaker subfamily potassium channel Kv1.3 [Gallus gallus] NP_001025549.1 0.0 83% ...

  8. NCBI nr-aa BLAST: CBRC-TSYR-01-1170 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-TSYR-01-1170 ref|NP_898745.1| putative cadmium resistance protein (CadA) [Rhod...ococcus erythropolis] gb|AAP74015.1| putative cadmium resistance protein (CadA) [Rhodococcus erythropolis] NP_898745.1 0.14 29% ...

  9. Parallel Tree Projection Algorithm for Sequence Mining

    Science.gov (United States)

    2001-03-29

    HPMA +00] was developed by extending the tree-projectionalgorithm [AAP00]. Even though, sequential association rule discovery algorithms based on tree...Kumar. Scalable parallel data mining for association rules. IEEETransactions on Knowledge and Data Eng. (accepted for publication), 1999.[ HPMA +00] J

  10. A study investigating sound sources and noise levels in neonatal ...

    African Journals Online (AJOL)

    This study aimed to identify noise sources in three NICUs in Johannesburg, South Africa, and to determine the sound levels to which neonates in incubators are exposed at various positions in the NICU. These findings were then compared with the standards recommended by the American Academy of Pediatrics (AAP).

  11. NCBI nr-aa BLAST: CBRC-PMAR-01-0463 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-PMAR-01-0463 ref|NP_833085.1| Collagen-like triple helix repeat protein [Bacil...lus cereus ATCC 14579] gb|AAP10286.1| Collagen-like triple helix repeat protein [Bacillus cereus ATCC 14579] NP_833085.1 5e-32 37% ...

  12. African Journal of Political Science

    African Journals Online (AJOL)

    The AJPS is published by the African Association of Political Science (AAPS), with the aim of providing a platform for African perspectives on issues of politics, economy and society in Africa. It is published 2 times a year - in June and December, and targeted at the social science community, policy-makers, and university ...

  13. TEMPLATE POLYMERIZATION OF N-VINYLIMIDAZOLE ALONG POLY(METHACRYLIC ACID) IN WATER .2. KINETICS OF THE TEMPLATE POLYMERIZATION

    NARCIS (Netherlands)

    VANDEGRAMPEL, HT; TAN, YY; CHALLA, G

    1991-01-01

    The template polymerization of N-vinylimidazole (VIm) along poly(methacrylic acid) (PMAA) in water at 50-degrees-C with 2,2'-azobis(2-amidinopropane).2HCl (AAP) as initiator was studied by using variable initiator and monomer concentrations at constant [PMAA]/[VIm]0. From the order in [VIm] it was

  14. Cow's milk - infants

    Science.gov (United States)

    ... cow's milk. To provide the best diet and nutrition for your infant, the AAP recommends: If possible, you should feed ... and the A.D.A.M. Editorial team. Infant and Newborn Nutrition Read more NIH MedlinePlus Magazine Read more Health ...

  15. Circumcision on the web: a comparison of quality, content, and bias online.

    Science.gov (United States)

    Coutinho, Karl; Stensland, Kristian; Hyun, Grace

    2014-08-01

    In 2012, the American Academy of Pediatrics (AAP) newborn circumcision policy statement expressed that although benefits outweigh risks, final decisions lie with parents. Although health information on the Internet is plentiful, the quality and availability of information on circumcision, including dissemination of AAP and AUA policy statements, is unknown. We analyzed English and Spanish circumcision websites to evaluate their overall quality, detail, accuracy, and bias. In April 2013, three search engines were queried for English and Spanish circumcision websites, which were analyzed utilizing the DISCERN Plus scale for content quality as well as additional study-specific criteria. We analyzed 214 websites (141 English, 73 Spanish). Most websites in both languages had very good content quality and were neutral regarding circumcision. Regardless of language, only 21% of sites mentioned the updated AAP guidelines. Surprisingly, the AUA circumcision policy statement did not appear in the top results. Spanish sites were more likely to give good descriptions of circumcision procedures than English sites (p Internet is of very good quality, but different English and Spanish characteristics possibly reflect cultural bias, which may explain the disparate rates of circumcision between different groups in the USA. The AAP's circumcision policy statement was referenced by a minority (20%) of websites, and AUA's policy statement was not even part of the top results. The AUA should have a more active role in providing accurate and comprehensive online information to parents regarding circumcision. Copyright © 2014 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved.

  16. Kosovo Armed Forces Development; Achieving NATO Non-Article 5 Crisis Response Operations Interoperability

    Science.gov (United States)

    2014-12-12

    Intercultural Factors. ................................................................................................. 27 Allied Administrative...Multinational Military Operations and Intercultural Factors, NATO Standard Allied Administrative Publication (AAP) 47 Allied Joint Doctrine Development, NATO...standards for Peace Support Operations. NATO RTO Technical Report Multinational Military Operations and Intercultural Factors. NATO Research and

  17. Evaluation of the Financial and Health Burden of Infants at Risk for Respiratory Syncytial Virus.

    Science.gov (United States)

    Blake, Stephanie McCallum; Tanaka, David; Bendz, Lisa M; Staebler, Suzanne; Brandon, Debra

    2017-08-01

    Respiratory syncytial virus (RSV) is the leading viral cause of death in infants younger than 1 year. In July 2014, the American Academy of Pediatrics (AAP) Committee on Infectious Diseases concluded that the "limited clinical benefit" for infants born at more than 29 weeks' gestation, together with the associated high cost of the immunoprophylaxis, no longer supported the routine use of palivizumab (Synagis). To evaluate the impact of the newly adopted AAP palivizumab prophylaxis administration on health and subsequent hospital costs of infants born between 29 and less than 32 weeks' gestation. A retrospective cohort analysis from a single institution across the duration of the study comparing the clinical and financial outcomes of infants (aged 29 weeks) managed after the 2014 AAP guidelines (POST) took effect. RSV-positive admissions were greater in the POST cohort versus the PRE cohort (P = .04). There were no readmission deaths due to RSV infection in either cohort. The number needed to treat to avoid a single RSV-positive hospitalization was 20 infants at an estimated palivizumab cost of $90,000 to avoid an estimated hospital cost of $29,000. Assessment of individual risk factors and their ability to predict severe RSV risk/disease, thus, would allow providers greater flexibility in determining need for prophylaxis therapy. Longitudinal evaluation of financial and clinical outcomes is needed to determine the impact of the 2014 AAP revised regulatory guidelines.

  18. Feasibility Study for Habitat Development Using Dredged Material at Jetty Island, Everett, Washington.

    Science.gov (United States)

    1984-07-01

    seashore sal tgrass (D~zjallbIs- s.pI SAtU), Jaunea (WTuimgO Asnai), Lilaeopsis 412,aaps.i. .i~dankaLa), low clubrush ({icixa entzmus)c ditcbgrass (.a...Jamea, Lilaeopsis , ditchgrass, low clubrush, and seaside plantain are .lso present in this zone In minor amounts and can be expected to establish at

  19. Using Acetaminophen's Toxicity Mechanism to Enhance Cisplatin Efficacy in Hepatocarcinoma and Hepatoblastoma Cell Lines

    Directory of Open Access Journals (Sweden)

    Alexander J. Neuwelt

    2009-10-01

    Conclusions: Our results suggest that a chemotherapeutic regimen containing both AAP and CDDP with delayed NAC rescue has the potential to enhance chemotherapeutic efficacy while decreasing adverse effects. This would be a promising approach particularly for hepatoblastomas regardless of cellular CYP2E1 protein level but could also be beneficial in other malignancies.

  20. Using Digital Materials in Online Courses: A Cautionary Tale of Georgia State University

    Science.gov (United States)

    Talab, Rosemary

    2008-01-01

    On April 15, 2008, a lawsuit was filed against Georgia State University by Cambridge University Press, Oxford University Press, and Sage, supported by the American University Presses (AAP). The complaint asserted ""pervasive, flagrant, and ongoing" unauthorized distribution of copyrighted materials...through its electronic course…

  1. Competitive adsorption of PPCP and humic substances by carbon nanotube membranes: Effects of coagulation and PPCP properties.

    Science.gov (United States)

    Wang, Yifei; Yang, Qing; Dong, Junqing; Huang, Haiou

    2017-11-16

    Natural organic matter (NOM) and pharmaceuticals and personal care products (PPCP) are known to compete for adsorption sites on carbon nanotubes (CNT), resulting in decreasing PPCP adsorption onto CNT. In this study, four types of PPCP, as such acetaminophen (AAP), caffeine (CAF), triclosan (TCS), and carbendazim (CBD) were used to investigate the effects of PPCP properties and NOM coagulation on the competitive adsorption of PPCP and NOM. Coagulation preferentially removed HS from a natural surface water, thereby increasing adsorption of AAP, CAF, TCS and CBD by 19%, 13%, 17% and 11%, respectively. Similar trends were obtained with synthetic natural waters, for which the adsorption of AAP, CAF, TCS, and CBD increased by 29%, 7%, 44% and 69%, respectively, as humic acid (HA) concentration decreased from 10mgL-1 to 0mgL-1. Furthermore, PPCP properties also affected their competition with NOM for adsorption by CNT membranes Because CAF existed in cationic form at pH ranging from 7 to 8.3, its adsorption was less affected by the presence/coagulation of NOM than AAP, CBD, and TCS. Based upon these findings, coagulation has the potential to be integrated with CNT adsorption for the removal of PPCP compounds during advanced drinking water treatment. Copyright © 2017 Elsevier B.V. All rights reserved.

  2. NCBI nr-aa BLAST: CBRC-MDOM-04-0142 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MDOM-04-0142 ref|YP_073290.1| NADH dehydrogenase subunit 5 [Pachypsylla venust...a] gb|AAP14655.1| NADH dehydrogenase subunit 5 [Pachypsylla venusta] YP_073290.1 0.039 25% ...

  3. Assessing the relationship between pediatric media guidance and media use in American families

    NARCIS (Netherlands)

    Lapierre, M.A.; Piotrowski, J.; Linebarger, D.L.

    2014-01-01

    Objective. American parents were surveyed to isolate demographic factors that predict reliance on a pediatrician, the American Academy of Pediatrics (AAP), or both for media guidance. We then investigated whether reliance on these resources resulted in different media practices with children.

  4. Routine DNA analysis based on 12S rRNA gene sequencing as a tool in the management of captive primates

    NARCIS (Netherlands)

    van der Kuyl, A. C.; van Gennep, D. R.; Dekker, J. T.; Goudsmit, J.

    2000-01-01

    Automated DNA sequencing of a fragment of the relatively slowly evolving mitochondrial 12S rRNA gene was used to distinguish primate species, and the method was compared with species determination based upon classical taxonomy. DNA from blood from 53 monkeys housed at the Stichting AAP Shelter for

  5. Korsten : tellimata tellised = Chimney : an outside job / Andres Aule

    Index Scriptorium Estoniae

    Aule, Andres

    2012-01-01

    Aap Kaur Suvi kavandatud Tallinna linnainstallatsioonide festivali "LIFT11" installatsioonist "Korsten", mis pidi seisnema Tauno Kangro skulptuuri "Lõbus korstnapühkija" ümber ajutise telliskorstna ehitamises. Lift11 jättis selle installatsiooni ära, kuid ootamatult sai "Korsten" kodanikualgatusena 8. IX 2011 teoks

  6. Rundum artist-run space and its elusive form / Hanna Laura Kaljo, Mari-Leen Kiipli, Kulla Laas ... [jt.

    Index Scriptorium Estoniae

    2015-01-01

    Rundum on 2013. a septembris Tallinnas loodud liikuv loominguline platvorm, mille eesmärgiks on suhestuda erinevate kohtadega, reageerida tühikutele Eesti loomemaastikus ning uurida sealjuures ka omaalgatuslike praktikate võimalikkust kohalikus kontekstis. Vestlusringis Rundumi algatajad Mari-Leen Kiipli, Kulla Laas, Aap Tepper, Mari Volens, Kristina Õllek

  7. Drosophila melanogaster females restore their attractiveness after mating by removing male anti-aphrodisiac pheromones

    NARCIS (Netherlands)

    Laturney, Meghan; Billeter, Jean-Christophe

    2016-01-01

    Males from many species ensure paternity by preventing their mates from copulating with other males. One mate-guarding strategy involves marking females with anti-aphrodisiac pheromones (AAPs), which reduces the females' attractiveness and dissuades other males from courting. Since females benefit

  8. Abiraterone Acetate for the Treatment of Chemotherapy-Naive Metastatic Castration-Resistant Prostate Cancer : An Evidence Review Group Perspective of an NICE Single Technology Appraisal

    NARCIS (Netherlands)

    Ramaekers, Bram L. T.; Riemsma, Rob; Tomini, Florian; van Asselt, Thea; Deshpande, Sohan; Duffy, Steven; Armstrong, Nigel; Severens, Johan L.; Kleijnen, Jos; Joore, Manuela A.

    The National Institute for Health and Care Excellence (NICE) invited Janssen, the company manufacturing abiraterone acetate (AA; tradename Zytiga(A (R))), to submit evidence for the clinical and cost effectiveness of AA in combination with prednisone/prednisolone (AAP) compared with watchful waiting

  9. NCBI nr-aa BLAST: CBRC-TTRU-01-0100 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-TTRU-01-0100 ref|YP_025744.1| NADH dehydrogenase subunit 4 [Ornithoctonus huwe...na] gb|AAP51154.2| NADH dehydrogenase subunit 4 [Ornithoctonus huwena] YP_025744.1 0.012 25% ...

  10. NCBI nr-aa BLAST: CBRC-OSAT-07-0033 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-OSAT-07-0033 ref|YP_025744.1| NADH dehydrogenase subunit 4 [Ornithoctonus huwe...na] gb|AAP51154.2| NADH dehydrogenase subunit 4 [Ornithoctonus huwena] YP_025744.1 3.2 25% ...

  11. NCBI nr-aa BLAST: CBRC-OGAR-01-0901 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-OGAR-01-0901 gb|AAP36559.1| Homo sapiens potassium voltage-gated channel, delayed...-rectifier, subfamily S, member 3 [synthetic construct] gb|AAX28989.1| potassium voltage-gated channel delayed

  12. NCBI nr-aa BLAST: CBRC-MLUC-01-0761 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MLUC-01-0761 gb|AAP36559.1| Homo sapiens potassium voltage-gated channel, delayed...-rectifier, subfamily S, member 3 [synthetic construct] gb|AAX28989.1| potassium voltage-gated channel delayed

  13. NCBI nr-aa BLAST: CBRC-TGUT-05-0042 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-TGUT-05-0042 gb|AAP36559.1| Homo sapiens potassium voltage-gated channel, delayed...-rectifier, subfamily S, member 3 [synthetic construct] gb|AAX28989.1| potassium voltage-gated channel delayed

  14. NCBI nr-aa BLAST: CBRC-ETEL-01-0884 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-ETEL-01-0884 gb|AAP36559.1| Homo sapiens potassium voltage-gated channel, delayed...-rectifier, subfamily S, member 3 [synthetic construct] gb|AAX28989.1| potassium voltage-gated channel delayed

  15. NCBI nr-aa BLAST: CBRC-EEUR-01-1046 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-EEUR-01-1046 gb|AAP36559.1| Homo sapiens potassium voltage-gated channel, delayed...-rectifier, subfamily S, member 3 [synthetic construct] gb|AAX28989.1| potassium voltage-gated channel delayed

  16. 75 FR 47819 - Workshop on Optimizing Clinical Trial Design for the Development of Pediatric Cardiovascular Devices

    Science.gov (United States)

    2010-08-09

    ... HUMAN SERVICES Food and Drug Administration Workshop on Optimizing Clinical Trial Design for the... support from the American Academy of Pediatrics (AAP), the American College of Cardiology (ACC), and the... ``Optimizing Clinical Trial Design for the Development of Pediatric Cardiovascular Devices.'' The topic to be...

  17. Diversity of cultivated and metabolically active aerobic anoxygenic phototrophic bacteria along an oligotrophic gradient in the Mediterranean Sea

    Directory of Open Access Journals (Sweden)

    C. Jeanthon

    2011-07-01

    Full Text Available Aerobic anoxygenic phototrophic (AAP bacteria play significant roles in the bacterioplankton productivity and biogeochemical cycles of the surface ocean. In this study, we applied both cultivation and mRNA-based molecular methods to explore the diversity of AAP bacteria along an oligotrophic gradient in the Mediterranean Sea in early summer 2008. Colony-forming units obtained on three different agar media were screened for the production of bacteriochlorophyll-a (BChl-a, the light-harvesting pigment of AAP bacteria. BChl-a-containing colonies represented a low part of the cultivable fraction. In total, 54 AAP strains were isolated and the phylogenetic analyses based on their 16S rRNA and pufM genes showed that they were all affiliated to the Alphaproteobacteria. The most frequently isolated strains belonged to Citromicrobium bathyomarinum, and Erythrobacter and Roseovarius species. Most other isolates were related to species not reported to produce BChl-a and/or may represent novel taxa. Direct extraction of RNA from seawater samples enabled the analysis of the expression of pufM, the gene coding for the M subunit of the reaction centre complex of aerobic anoxygenic photosynthesis. Clone libraries of pufM gene transcripts revealed that most phylotypes were highly similar to sequences previously recovered from the Mediterranean Sea and a large majority (~94 % was affiliated to the Gammaproteobacteria. The most abundantly detected phylotypes occurred in the western and eastern Mediterranean basins. However, some were exclusively detected in the eastern basin, reflecting the highest diversity of pufM transcripts observed in this ultra-oligotrophic region. To our knowledge, this is the first study to document extensively the diversity of AAP isolates and to unveil the active AAP community in an oligotrophic marine environment. By pointing out the discrepancies

  18. Well-child visits in the video age: pediatricians and the American Academy of Pediatrics' guidelines for children's media use.

    Science.gov (United States)

    Gentile, Douglas A; Oberg, Charles; Sherwood, Nancy E; Story, Mary; Walsh, David A; Hogan, Marjorie

    2004-11-01

    The goal of this study was to evaluate awareness of, agreement with, and implementation of the American Academy of Pediatrics (AAP) media use guidelines among pediatricians. Pediatricians' beliefs about several media effects were also measured, as was their own media use. Pediatricians were also asked about how often they make media recommendations as part of anticipatory guidance during well-child visits, as well as the perceived efficacy of and barriers to making such recommendations. A cross-sectional survey mailed to all members of the Minnesota chapter of the AAP. A total of 365 pediatricians completed the survey. The 58-item survey assessed familiarity with, agreement with, and implementation of each of 3 AAP recommendations, to limit children's media time, to discourage television (TV) viewing among children habits and their opinions about how much media affect children's health and behavior. Most pediatricians were familiar with and also agreed with the 3 AAP recommendations. Their agreement may stem from the fact that pediatricians almost universally believe that children's media use negatively affects children in many different areas, including children's aggressive behavior, eating habits, physical activity levels, risk for obesity, high-risk behaviors, and school performance. Pediatricians were most likely to have encouraged alternative entertainment and were least likely to have discouraged TV viewing for children media habits as barriers. Finally, pediatricians who watched the greatest amounts of TV were significantly more likely than those who watched less to think that the AAP recommendation to limit children's total media time to no more than 1 to 2 hours per day is unrealistic, whereas those who watched less were more likely to agree with the recommendation. Results suggest that the efforts of the AAP in reaching pediatricians have been largely successful, with the majority of pediatricians in Minnesota being aware of and agreeing with the 3 major

  19. Smartphone-based vs paper-based asthma action plans for adolescents.

    Science.gov (United States)

    Perry, Tamara T; Marshall, Alexandra; Berlinski, Ariel; Rettiganti, Mallikarjuna; Brown, Rita H; Randle, Shemeka M; Luo, Chunqiao; Bian, Jiang

    2017-03-01

    Adolescents with asthma are at risk of poor outcomes and are traditionally difficult to reach. To examine adolescents' use of and asthma outcomes associated with smartphone- vs paper-based asthma action plans (AAPs). We conducted a 6-month randomized clinical trial with adolescents (12-17 years old) with persistent asthma. Participants used their respective smartphone or paper AAPs for medication instructions and peak flow or asthma symptoms logging. AAP use was measured electronically for smartphone users and via mail-in diaries for the paper group. Changes in Asthma Control Test (ACT) and self-efficacy scores were examined. Thirty-four adolescents participated in this study (median age, 15.4 years). Participants were mostly African American (62%) with state-issued insurance (71%). Adolescents in the smartphone group accessed the AAP a median of 12.17 times per week or 4.36 days per week but only recorded medications or symptoms and peak flow data in the electronic diary a median of 10 days per month during the 6-month period. Participants in the paper group recorded data a median of 23.5 days per month on their paper diaries. Overall, there were no changes in ACT and self-efficacy scores between groups. Adolescents with uncontrolled asthma (baseline ACT score ≤19) had an improvement in ACT for the smartphone group (before, 11; after, 20) ([P = .04) compared with no change in the paper group (before, 17; after, 17) (P = .64). Adolescent satisfaction with the application was high, with 100% stating they would recommend the smartphone AAP to a friend. Adolescents were frequent and highly satisfied users of the smartphone AAP with a subset of participants with uncontrolled asthma demonstrating possible clinical benefit. Findings suggest a need for larger-scale studies to determine the effectiveness of smartphone-based AAPs among high-risk patients with asthma. clinicaltrials.gov Identifier: NCT02091869. Copyright © 2016 American College of Allergy, Asthma

  20. Comparison of high resolution x-ray detectors with conventional FPDs using experimental MTFs and apodized aperture pixel design for reduced aliasing

    Science.gov (United States)

    Shankar, A.; Russ, M.; Vijayan, S.; Bednarek, D. R.; Rudin, S.

    2017-03-01

    Apodized Aperture Pixel (AAP) design, proposed by Ismailova et.al, is an alternative to the conventional pixel design. The advantages of AAP processing with a sinc filter in comparison with using other filters include non-degradation of MTF values and elimination of signal and noise aliasing, resulting in an increased performance at higher frequencies, approaching the Nyquist frequency. If high resolution small field-of-view (FOV) detectors with small pixels used during critical stages of Endovascular Image Guided Interventions (EIGIs) could also be extended to cover a full field-of-view typical of flat panel detectors (FPDs) and made to have larger effective pixels, then methods must be used to preserve the MTF over the frequency range up to the Nyquist frequency of the FPD while minimizing aliasing. In this work, we convolve the experimentally measured MTFs of an Microangiographic Fluoroscope (MAF) detector, (the MAF-CCD with 35μm pixels) and a High Resolution Fluoroscope (HRF) detector (HRF-CMOS50 with 49.5μm pixels) with the AAP filter and show the superiority of the results compared to MTFs resulting from moving average pixel binning and to the MTF of a standard FPD. The effect of using AAP is also shown in the spatial domain, when used to image an infinitely small point object. For detectors in neurovascular interventions, where high resolution is the priority during critical parts of the intervention, but full FOV with larger pixels are needed during less critical parts, AAP design provides an alternative to simple pixel binning while effectively eliminating signal and noise aliasing yet allowing the small FOV high resolution imaging to be maintained during critical parts of the EIGI.

  1. Effects of the Adult Attachment Projective Picture System on oxytocin and cortisol blood levels in mothers

    Directory of Open Access Journals (Sweden)

    Sabrina Krause

    2016-12-01

    Full Text Available Oxytocin, a small neuropeptide of nine amino acids, has been characterized as the hormone of affiliation and is stimulated, for instance, in mothers when interacting with their offspring. Variations in maternal oxytocin levels were reported to predict differences in the quality of care provided by mothers. In this study, the Adult Attachment Projective Picture System (AAP as a valid measure to assess attachment representations was used as an activating attachment-related stimulus. We investigated whether the AAP induces a release of oxytocin in mothers with a secure attachment representation and a stress-related cortisol response in mothers with an insecure attachment representation. Therefore, pre-post effects of AAP administration on plasma oxytocin and serum cortisol levels were investigated in n = 44 mothers 3 months after parturition. Oxytocin levels increased from pre to post by the significant majority of 73% participants (p = .004 and cortisol decreased by the significant majority of 73% participants (p = .004. Interestingly, no association between alterations in oxytocin and cortisol were found; this suggests taking a model of two independent processes into considerations. These results show that the AAP test procedure induces an oxytocin response. Concerning the results within the four AAP representation subgroups, our hypothesis of a particularly strong increase in oxytocin in secure mothers was not confirmed; however, in secure mothers we observed a particularly strong decrease in cortisol, consistent with our hypotheses. Effect sizes are reported, allowing the replication of results in a larger study with sufficient sample size to draw final conclusions with respect to differences in OT and cortisol alterations depending on attachment representation. When interpreting the results, one should keep in mind that this study investigated lactating mothers. Thus, the generalizability of results is limited and future studies should

  2. The Effect of Secretory Factors of Adipose-Derived Stem Cells on Human Keratinocytes

    Directory of Open Access Journals (Sweden)

    Soo-Wan Nam

    2012-01-01

    Full Text Available The beneficial effects of adipose-derived stem cell conditioned medium (ADSC-CM on skin regeneration have been reported. Although the mechanism of how ADSC-CM promotes skin regeneration is unclear, ADSC-CM contained various growth factors and it is an excellent raw material for skin treatment. ADSC-CM produced in a hypoxia condition of ADSC—in other words, Advanced Adipose-Derived Stem cell Protein Extract (AAPE—has great merits for skin regeneration. In this study, human primary keratinocytes (HKs, which play fundamental roles in skin tissue, was used to examine how AAPE affects HK. HK proliferation was significantly higher in the experimental group (1.22 μg/mL than in the control group. DNA gene chip demonstrated that AAPE in keratinocytes (p < 0.05 notably affected expression of 290 identified transcripts, which were associated with cell proliferation, cycle and migration. More keratinocyte wound healing and migration was shown in the experimental group (1.22 μg/mL. AAPE treatment significantly stimulated stress fiber formation, which was linked to the RhoA-ROCK pathway. We identified 48 protein spots in 2-D gel analysis and selected proteins were divided into 64% collagen components and 30% non-collagen components as shown by the MALDI-TOF analysis. Antibody array results contained growth factor/cytokine such as HGF, FGF-1, G-CSF, GM-CSF, IL-6, VEGF, and TGF-β3 differing from that shown by 2-D analysis. Conclusion: AAPE activates HK proliferation and migration. These results highlight the potential of the topical application of AAPE in the treatment of skin regeneration.

  3. Role of symbiotic auxotrophy in the Rhizobium-legume symbioses.

    Directory of Open Access Journals (Sweden)

    Jurgen Prell

    2010-11-01

    Full Text Available Rhizobium leguminosarum bv. viciae mutants unable to transport branched-chain amino acids via the two main amino acid ABC transport complexes AapJQMP and BraDEFGC produce a nitrogen starvation phenotype when inoculated on pea (Pisum sativum plants [1], [2]. Bacteroids in indeterminate pea nodules have reduced abundance and a lower chromosome number. They reduce transcription of pathways for branched-chain amino acid biosynthesis and become dependent on their provision by the host. This has been called "symbiotic auxotrophy".A region important in solute specificity was identified in AapQ and changing P144D in this region reduced branched-chain amino acid transport to a very low rate. Strains carrying P144D were still fully effective for N(2 fixation on peas demonstrating that a low rate of branched amino acid transport in R. leguminosarum bv. viciae supports wild-type rates of nitrogen fixation. The importance of branched-chain amino acid transport was then examined in other legume-Rhizobium symbioses. An aap bra mutant of R. leguminosarum bv. phaseoli also showed nitrogen starvation symptoms when inoculated on French bean (Phaseolus vulgaris, a plant producing determinate nodules. The phenotype is different from that observed on pea and is accompanied by reduced nodule numbers and nitrogen fixation per nodule. However, an aap bra double mutant of Sinorhizobium meliloti 2011 showed no phenotype on alfalfa (Medicago sativa.Symbiotic auxotrophy occurs in both determinate pea and indeterminate bean nodules demonstrating its importance for bacteroid formation and nodule function in legumes with different developmental programmes. However, only small quantities of branched chain amino acids are needed and symbiotic auxotrophy did not occur in the Sinorhizobium meliloti-alfalfa symbiosis under the conditions measured. The contrasting symbiotic phenotypes of aap bra mutants inoculated on different legumes probably reflects altered timing of amino acid

  4. Role of symbiotic auxotrophy in the Rhizobium-legume symbioses.

    Science.gov (United States)

    Prell, Jurgen; Bourdès, Alexandre; Kumar, Shalini; Lodwig, Emma; Hosie, Arthur; Kinghorn, Seonag; White, James; Poole, Philip

    2010-11-11

    Rhizobium leguminosarum bv. viciae mutants unable to transport branched-chain amino acids via the two main amino acid ABC transport complexes AapJQMP and BraDEFGC produce a nitrogen starvation phenotype when inoculated on pea (Pisum sativum) plants [1], [2]. Bacteroids in indeterminate pea nodules have reduced abundance and a lower chromosome number. They reduce transcription of pathways for branched-chain amino acid biosynthesis and become dependent on their provision by the host. This has been called "symbiotic auxotrophy". A region important in solute specificity was identified in AapQ and changing P144D in this region reduced branched-chain amino acid transport to a very low rate. Strains carrying P144D were still fully effective for N(2) fixation on peas demonstrating that a low rate of branched amino acid transport in R. leguminosarum bv. viciae supports wild-type rates of nitrogen fixation. The importance of branched-chain amino acid transport was then examined in other legume-Rhizobium symbioses. An aap bra mutant of R. leguminosarum bv. phaseoli also showed nitrogen starvation symptoms when inoculated on French bean (Phaseolus vulgaris), a plant producing determinate nodules. The phenotype is different from that observed on pea and is accompanied by reduced nodule numbers and nitrogen fixation per nodule. However, an aap bra double mutant of Sinorhizobium meliloti 2011 showed no phenotype on alfalfa (Medicago sativa). Symbiotic auxotrophy occurs in both determinate pea and indeterminate bean nodules demonstrating its importance for bacteroid formation and nodule function in legumes with different developmental programmes. However, only small quantities of branched chain amino acids are needed and symbiotic auxotrophy did not occur in the Sinorhizobium meliloti-alfalfa symbiosis under the conditions measured. The contrasting symbiotic phenotypes of aap bra mutants inoculated on different legumes probably reflects altered timing of amino acid availability

  5. Metabolic Syndrome and Insulin Resistance in Schizophrenia Patients Receiving Antipsychotics Genotyped for the Methylenetetrahydrofolate Reductase (MTHFR) 677C/T and 1298A/C Variants

    Science.gov (United States)

    Ellingrod, Vicki L.; Miller, Del D.; Taylor, Stephan F.; Moline, Jessica; Holman, Timothy; Kerr, Jane

    2008-01-01

    Introduction The metabolic syndrome and insulin resistance represent growing concerns related to atypical antipsychotic (AAP) use as their incidence in the schizophrenia population is two to four fold higher than the general population. Reduced methylenetetrahydrofolate reductase (MTHFR) activity, resulting in aberrant folate metabolism and hyperhomocysteinemia, has been linked to cardiovascular disease and is unstudied in relation to AAP associated metabolic complications. Purpose To examine the relationship between MTHFR, metabolic syndrome, and insulin resistance in schizophrenia subjects receiving AAPs for ≥ 12 months. Methods Fifty-eight subjects were included in this cross-sectional analysis and screened for the metabolic syndrome, insulin resistance and MTHFR 677C/T and 1298 A/C genotype. Results Overall, 23 subjects (40%) met metabolic syndrome criteria. There were no differences in age, gender, race, or AAP exposure between genotype groups. For the 677 T allele carriers, 53% met metabolic syndrome criteria, compared to 23% in the CC genotype group, giving an OR = 3.7, (95% CI = 1.24 – 12.66, p = 0.02). Thus, for T allele subjects, the risk was almost four times greater, despite similar antipsychotic exposure. Both waist circumference and MTHFR genotype significantly predicted insulin resistance (F = 8.35, df = 5, 51, p < 0.0001), with these two terms interacting (F = 8.6, df = 2, p = 0.0006) suggesting TT subjects are at greater risk for insulin resistance with increasing central adiposity, which is independent of age, gender, BMI, or metabolic syndrome diagnosis. Conclusion Results should be taken cautiously due to the small sample size, but suggest the MTHFR 677C/T variant may predispose patients to AAP metabolic complications. PMID:17976958

  6. Identifying Sources of Funding That Contribute to Scholastic Productivity in Academic Plastic Surgeons.

    Science.gov (United States)

    Ruan, Qing Zhao; Cohen, Justin B; Baek, Yoonji; Chen, Austin D; Doval, Andres F; Singhal, Dhruv; Fukudome, Eugene Y; Lin, Samuel J; Lee, Bernard T

    2018-01-09

    Scholastic productivity has previously been shown to be positively associated with National Institute of Health (NIH) grants and industry funding. This study examines whether society, industry, or federal funding contributes toward academic productivity as measured by scholastic output of academic plastic surgeons. Institution Web sites were used to acquire academic attributes of full-time academic plastic surgeons. The Center for Medicare and Medicaid Services Open Payment database, NIH reporter, the Plastic Surgery Foundation (PSF), and American Association of Plastic Surgeons (AAPS) Web sites were accessed for funding and endowment details. Bibliometric data of each surgeon were then collected via Scopus to ascertain strengths of association with each source. Multiple linear regression analysis was used to identify significant contributors to high scholastic output. We identified 935 academic plastic surgeons with 94 (10.1%), 24 (2.6%), 724 (77.4%), and 62 (6.6%) receiving funding from PSF, AAPS, industry, and NIH, respectively. There were positive correlations in receiving NIH, PSF, and/or AAPS funding (P < 0.001), whereas industry funding was found to negatively associate with PSF (r = -0.75, P = 0.022) grants. The NIH R award was consistently found to be the most predictive of academic output across bibliometrics, followed by the AAPS academic scholarship award. Conventional measures of academic seniority remained predictive across all measures used. Our study demonstrates for the first time interactions between industry, federal, and association funding. The NIH R award was the strongest determinant of high scholastic productivity. Recognition through AAPS academic scholarships seemed to associate with subsequent success in NIH funding.

  7. Animal-assisted psychotherapy for young people with behavioural problems in residential care.

    Science.gov (United States)

    Muela, Alexander; Balluerka, Nekane; Amiano, Nora; Caldentey, Miguel Angel; Aliri, Jone

    2017-11-01

    The aim of this study was to evaluate the impact of an animal-assisted psychotherapy (AAP) programme on clinical symptoms, personal adjustment, and adaptive skills in a group of adolescents in residential care who had experienced childhood trauma and who presented mental health problems and difficulties adapting to the care home environment. The 87 participants (Mage  = 15.17, SD = 1.53) were divided into two groups: a treatment group (25 girls and 27 boys; Mage  = 15.00, SD = 1.55) and a control group (9 girls and 26 boys; Mage  = 15.42, SD = 1.50). The programme consisted of 34 sessions involving both group (23 sessions) and individual (11 sessions) AAP. The Behaviour Assessment System for Children was used to evaluate clinical and adaptive dimensions of behaviour and personality. The results indicated that, in comparison with controls, the young people who took part in the AAP programme reported a significant improvement on two measures of internalizing symptoms, namely, depression and sense of inadequacy. Although no significant differences were observed in relation to externalizing symptoms, the adolescents who received the AAP programme showed improved social skills in terms of their ability to interact satisfactorily with peers and adults in the care home environment, as well as a more positive attitude towards teachers at school. These results suggest that AAP may be a promising treatment for young people who have experienced childhood trauma and who subsequently find it difficult to adapt to the residential care setting. Copyright © 2017 John Wiley & Sons, Ltd.

  8. Medicine and medical sciences in Africa.

    Science.gov (United States)

    Gathiram, Prem; Hänninen, Osmo

    2014-06-01

    The year 2014 is an important year because it will mark the 25th Anniversary of the founding of the African Association of Physiological Sciences (AAPS) and initial talks to launch the International Society for Pathophysiology (ISP). Both these organizations had a foothold in Finland and both occurred during the IUPS Centennial Celebration Congress in 1989. The congress was hosted by the Finnish Physiological Society in Helsinki, Finland in July 1989. For both organizations, Prof OsmoHänninen was instrumental in the launching and inauguration of AAPS and also to initiate the creation of ISP. In order to celebrate the 25th Anniversaries of both organizations it was decided to hold the ISP2014 congress on the African soil. Hence in 2004, at the 4th international congress of AAPS held in Morocco, Wail Benjeloun.the then secretary general of AAPS, submitted successfully a bid to host ISP2014 in Morocco. Following the inauguration of AAPS in Helsinki, the 1st Congress of AAPS was held in Nairobi, Kenya in 1992 where the Constitution of AAPS was drawn up. The Constitution was adopted at the 2nd congress of AAPS in Durban, South Africa in 1997. Following this congress, the next congress, as scheduled, was held in Pretoria, South Africa in 2000. The last congress (6th) of AAPS was held on 1-5 September 2012 in Ismailia, Egypt. This was an historical congress because of many reasons and amongst these was the appointment of Anthony B. Ebeigbe, Department of Physiology, University of Benin, Nigeria as its first Editor-in-Chief of its official journal, the Journal of the African association of Physiological Sciences (JAAPS). He successfully published the first issue in June 2013, as mandated in Ismailia. The World's medicine has its initial root in Africa and in fact it was in Memphis, Egypt as early as 2700 BC. During the Ptulomaic period the seat of medicine was in Alexandria, Egypt and Medical knowledge then spread to the Greeks 330 BC. Many western medical scientists

  9. Active appearance pyramids for object parametrisation and fitting.

    Science.gov (United States)

    Zhang, Qiang; Bhalerao, Abhir; Dickenson, Edward; Hutchinson, Charles

    2016-08-01

    Object class representation is one of the key problems in various medical image analysis tasks. We propose a part-based parametric appearance model we refer to as an Active Appearance Pyramid (AAP). The parts are delineated by multi-scale Local Feature Pyramids (LFPs) for superior spatial specificity and distinctiveness. An AAP models the variability within a population with local translations of multi-scale parts and linear appearance variations of the assembly of the parts. It can fit and represent new instances by adjusting the shape and appearance parameters. The fitting process uses a two-step iterative strategy: local landmark searching followed by shape regularisation. We present a simultaneous local feature searching and appearance fitting algorithm based on the weighted Lucas and Kanade method. A shape regulariser is derived to calculate the maximum likelihood shape with respect to the prior and multiple landmark candidates from multi-scale LFPs, with a compact closed-form solution. We apply the 2D AAP on the modelling of variability in patients with lumbar spinal stenosis (LSS) and validate its performance on 200 studies consisting of routine axial and sagittal MRI scans. Intervertebral sagittal and parasagittal cross-sections are typically used for the diagnosis of LSS, we therefore build three AAPs on L3/4, L4/5 and L5/S1 axial cross-sections and three on parasagittal slices. Experiments show significant improvement in convergence range, robustness to local minima and segmentation precision compared with Constrained Local Models (CLMs), Active Shape Models (ASMs) and Active Appearance Models (AAMs), as well as superior performance in appearance reconstruction compared with AAMs. We also validate the performance on 3D CT volumes of hip joints from 38 studies. Compared to AAMs, AAPs achieve a higher segmentation and reconstruction precision. Moreover, AAPs have a significant improvement in efficiency, consuming about half the memory and less than 10% of

  10. Secondhand smoke in combination with ambient air pollution exposure is associated with increasedx CpG methylation and decreased expression of IFN-γ in T effector cells and Foxp3 in T regulatory cells in children

    Directory of Open Access Journals (Sweden)

    Kohli Arunima

    2012-09-01

    Full Text Available Abstract Background Secondhand smoke (SHS and ambient air pollution (AAP exposures have been associated with increased prevalence and severity of asthma and DNA modifications of immune cells. In the current study, we examined the association between SHS and AAP with DNA methylation and expression of interferon-gamma (IFN-γ and forkhead box protein 3 (Foxp3 in T cell populations. Methods Subjects 7–18 years old were recruited from Fresno (high AAP; n = 62 and Stanford, CA (low AAP; n = 40 and divided into SHS-exposed (Fresno: n = 31, Stanford: n = 6 and non-SHS-exposed (nSHS; Fresno: n = 31, Stanford: n = 34 groups. T cells purified from peripheral blood were assessed for levels of DNA methylation and expression of IFN-γ (in effector T cells or Foxp3 (in regulatory T cells. Results Analysis showed a significant increase in mean % CpG methylation of IFN-γ and Foxp3 associated with SHS exposure (IFN-γ: FSHS 62.10%, FnSHS 41.29%, p p Foxp3: FSHS 74.60%, FnSHS 54.44%, p p IFN-γ: FSHS 0.75, FnSHS 1.52, p p Foxp3: FSHS 0.75, FnSHS 3.29, p p IFN-γ: FSHS vs. SSHS, p p Foxp3: FSHS vs. SSHS, p p IFN-γ: FSHS vs. SSHS, p p Foxp3: FSHS vs. SSHS, p p IFN-γ: p = 0.15; Foxp3: p = 0.27, nor was Foxp3 expression (p = 0.08; IFN-γ expression was significantly decreased in AAP-only subjects (p  Conclusions Exposures to SHS and AAP are associated with significant hypermethylation and decreased expression of IFN-γ in Teffs and Foxp3 in Tregs. Relative contributions of each exposure to DNA modification and asthma pathogenesis warrant further investigation.

  11. Au@Ag/Au nanoparticles assembled with activatable aptamer probes as smart ``nano-doctors'' for image-guided cancer thermotherapy

    Science.gov (United States)

    Shi, Hui; Ye, Xiaosheng; He, Xiaoxiao; Wang, Kemin; Cui, Wensi; He, Dinggeng; Li, Duo; Jia, Xuekun

    2014-07-01

    Although nanomaterial-based theranostics have increased positive expectations from cancer treatment, it remains challenging to develop in vivo ``nano-doctors'' that provide high-contrast image-guided site-specific therapy. Here we designed an activatable theranostic nanoprobe (ATNP) via self-assembly of activatable aptamer probes (AAPs) on Au@Ag/Au nanoparticles (NPs). As both quenchers and heaters, novel Au@Ag/Au NPs were prepared, showing excellent fluorescence quenching and more effective near-infrared photothermal therapy than Au nanorods. The AAP comprised a thiolated aptamer and a fluorophore-labeled complementary DNA; thus, the ATNP with quenched fluorescence in the free state could realize signal activation through target binding-induced conformational change of the AAP, and then achieve on-demand treatment under image-guided irradiation. By using S6 aptamer as the model, in vitro and in vivo studies of A549 lung cancer verified that the ATNP greatly improved imaging contrast and specific destruction, suggesting a robust and versatile theranostic strategy for personalized medicine in future.Although nanomaterial-based theranostics have increased positive expectations from cancer treatment, it remains challenging to develop in vivo ``nano-doctors'' that provide high-contrast image-guided site-specific therapy. Here we designed an activatable theranostic nanoprobe (ATNP) via self-assembly of activatable aptamer probes (AAPs) on Au@Ag/Au nanoparticles (NPs). As both quenchers and heaters, novel Au@Ag/Au NPs were prepared, showing excellent fluorescence quenching and more effective near-infrared photothermal therapy than Au nanorods. The AAP comprised a thiolated aptamer and a fluorophore-labeled complementary DNA; thus, the ATNP with quenched fluorescence in the free state could realize signal activation through target binding-induced conformational change of the AAP, and then achieve on-demand treatment under image-guided irradiation. By using S6 aptamer as

  12. From porous gold nanocups to porous nanospheres and solid particles - A new synthetic approach

    KAUST Repository

    Ihsan, Ayesha

    2015-05-01

    We report a versatile approach for the synthesis of porous gold nanocups, porous gold nanospheres and solid gold nanoparticles. Gold nanocups are formed by the slow reduction of gold salt (HAuCl4{dot operator}3H2O) using aminoantipyrene (AAP) as a reducing agent. Adding polyvinylpyrrolidone (PVP) to the gold salt followed by reduction with AAP resulted in the formation of porous gold nanospheres. Microwave irradiation of both of these porous gold particles resulted in the formation of slightly smaller but solid gold particles. All these nanoparticles are thoroughly characterized by UV-visible spectroscopy, scanning electron microscopy (SEM), high resolution transmission electron microscopy (HR-TEM) and bright-field tomography. Due to the larger size, porous nature, low density and higher surface area, these nanomaterials may have interesting applications in catalysis, drug delivery, phototherapy and sensing.

  13. Cadmium-induced oxidative stress in potato tuber

    Directory of Open Access Journals (Sweden)

    Andrzej Stroiński

    2014-01-01

    Full Text Available Short-term treatment of tuber discs of potato (Solanum tuberosum L. with cadmium chloride elevated the concentration of active oxygen species (.O-2, H202 and activated the antioxidative system. Two cultivars, Bintje and Bzura, susceptible and tolerant, respectively, to cadmium were examined. In more tolerant, control tissues the activity of ascorbic acid peroxidase (AAP and catalase (CAT was higher than in the sensitive ones. During first hours of stress, the inhibition of superoxide dismutase (SOD, CAT and AAP was observed and it comes from inactivation of enzymes by cadmium ions. A subsequent activity increase of the enzymes aroused earlier in tolerant tissues. It seems therefore, that tolerant tissues possess a more efficient antioxidative system.

  14. Resolution of alliance ruptures: The special case of animal-assisted psychotherapy.

    Science.gov (United States)

    Zilcha-Mano, Sigal

    2017-01-01

    Many therapists regard alliance ruptures as one of the greatest challenges therapists face in the therapy room. Alliance ruptures has been previously defined as breakdowns in the process of negotiation of treatment tasks and goals and a deterioration in the affective bond between patient and therapist. Alliance ruptures have been found to predict premature termination of treatment and poor treatment outcomes. But ruptures can also present important opportunities for gaining insight and awareness and for facilitating therapeutic change. A process of rupture resolution may lead to beneficial outcomes and serve as a corrective emotional experience. The article describes unique processes of alliance rupture resolution inherent in animal-assisted psychotherapy (AAP). Building on Safran and Muran's model and on clinical examples, the article describes strategies for identifying ruptures in AAP and techniques for repairing them to facilitate a corrective experience in treatment. Implications for clinical practice and future research are discussed.

  15. Level-2 Milestone 5588: Deliver Strategic Plan and Initial Scalability Assessment by Advanced Architecture and Portability Specialists Team

    Energy Technology Data Exchange (ETDEWEB)

    Draeger, Erik W. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2016-09-30

    This report documents the fact that the work in creating a strategic plan and beginning customer engagements has been completed. The description of milestone is: The newly formed advanced architecture and portability specialists (AAPS) team will develop a strategic plan to meet the goals of 1) sharing knowledge and experience with code teams to ensure that ASC codes run well on new architectures, and 2) supplying skilled computational scientists to put the strategy into practice. The plan will be delivered to ASC management in the first quarter. By the fourth quarter, the team will identify their first customers within PEM and IC, perform an initial assessment and scalability and performance bottleneck for next-generation architectures, and embed AAPS team members with customer code teams to assist with initial portability development within standalone kernels or proxy applications.

  16. Anorexia and Attachment: Dysregulated Defense and Pathological Mourning

    Directory of Open Access Journals (Sweden)

    elisa edelvecchio

    2014-10-01

    Full Text Available The role of Defensive exclusion (Deactivation and Segregated Systems in the development of early relationships and related to subsequent manifestations of symptoms of eating disorders was assessed using the Adult Attachment Projective Picture System (AAP. Fifty-one DSM-IV diagnosed women with anorexia participated in the study. Anorexic patients were primarily classified as dismissing or unresolved. Quantitative and qualitative analyses of defensive exclusion were carried out. Results showed potential benefits of using the AAP defense exclusion coding system, in addition to the main attachment classifications, in order to better understand the developmental issues involved in anorexia. Discussion concerned the processes, such as pathological mourning, that may underlie the associations between dismissing and unresolved attachment and anorexia. Implications for developmental research and clinical nosology are discussed.

  17. Surveying Turkish high school and university student attitudes and approaches to physics problem solving

    CERN Document Server

    Balta, Nuri; Singh, Chandralekha

    2016-01-01

    Student attitudes and approaches to problem solving can impact how well they learn physics. Prior research in the US using a validated Attitude and Approaches to Problem Solving (AAPS) survey suggests that there are major differences between students in introductory physics and astronomy courses and physics experts in terms of their attitudes and approaches to physics problem solving. Here we discuss the validation, administration and analysis of data for the Turkish version of the AAPS survey for high school and university students in Turkey. After the validation and administration of the Turkish version of the survey, the analysis of the data was conducted by grouping the data by grade level, school type, and gender. While there are no statistically significant differences between the averages of various groups on the survey, overall, the university students in Turkey were more expert-like than vocational high school students. On an item by item basis, there are statistically differences between the average...

  18. Correlation between aortic/carotid atherosclerotic plaques and cerebral infarction.

    Science.gov (United States)

    Wang, Baojun; Sun, Shaoli; Liu, Guorong; Li, Yuechun; Pang, Jiangxia; Zhang, Jingfen; Yang, Lijuan; Li, Ruiming; Zhang, Hui; Jiang, Changchun; Li, Xiue

    2013-08-01

    The aim of this study was to investigate the correlation between aortic/carotid atherosclerotic plaques and cerebral infarction. We examined 116 cases of cerebral infarction using transcranial Doppler ultrasound in order to exclude cerebrovascular stenosis. Transesophageal echocardiography and color Doppler ultrasound were used to detect aortic atherosclerotic plaques (AAPs) and carotid atherosclerotic plaques (CAPs). AAPs were detected in a total of 70 of the 116 cases (60.3%), including 56 with moderate/severe atherosclerotic changes (48.3%). The difference in the incidence of various types of infarction between APP severity levels was significant (PCAPs (55.2%), including 46 with unstable plaque (39.7%). The difference in the incidence of various types of infarction between CAP stability levels was significant (PCAP are significant causes of embolic infarction without stenosis in the internal carotid arteries.

  19. Adding abiraterone to androgen deprivation therapy in men with metastatic hormone-sensitive prostate cancer: A systematic review and meta-analysis.

    Science.gov (United States)

    Rydzewska, Larysa H M; Burdett, Sarah; Vale, Claire L; Clarke, Noel W; Fizazi, Karim; Kheoh, Thian; Mason, Malcolm D; Miladinovic, Branko; James, Nicholas D; Parmar, Mahesh K B; Spears, Melissa R; Sweeney, Christopher J; Sydes, Matthew R; Tran, NamPhuong; Tierney, Jayne F

    2017-10-01

    There is a need to synthesise the results of numerous randomised controlled trials evaluating the addition of therapies to androgen deprivation therapy (ADT) for men with metastatic hormone-sensitive prostate cancer (mHSPC). This systematic review aims to assess the effects of adding abiraterone acetate plus prednisone/prednisolone (AAP) to ADT. Using our framework for adaptive meta-analysis (FAME), we started the review process before trials had been reported and worked collaboratively with trial investigators to anticipate when eligible trial results would emerge. Thus, we could determine the earliest opportunity for reliable meta-analysis and take account of unavailable trials in interpreting results. We searched multiple sources for trials comparing AAP plus ADT versus ADT in men with mHSPC. We obtained results for the primary outcome of overall survival (OS), secondary outcomes of clinical/radiological progression-free survival (PFS) and grade III-IV and grade V toxicity direct from trial teams. Hazard ratios (HRs) for the effects of AAP plus ADT on OS and PFS, Peto Odds Ratios (Peto ORs) for the effects on acute toxicity and interaction HRs for the effects on OS by patient subgroups were combined across trials using fixed-effect meta-analysis. We identified three eligible trials, one of which was still recruiting (PEACE-1 (NCT01957436)). Results from the two remaining trials (LATITUDE (NCT01715285) and STAMPEDE (NCT00268476)), representing 82% of all men randomised to AAP plus ADT versus ADT (without docetaxel in either arm), showed a highly significant 38% reduction in the risk of death with AAP plus ADT (HR = 0.62, 95% confidence interval [CI] = 0.53-0.71, p = 0.55 × 10-10), that translates into a 14% absolute improvement in 3-year OS. Despite differences in PFS definitions across trials, we also observed a consistent and highly significant 55% reduction in the risk of clinical/radiological PFS (HR = 0.45, 95% CI = 0.40-0.51, p = 0.66

  20. Current pediatric rheumatology fellowship training in the United States: what fellows actually do.

    Science.gov (United States)

    Patwardhan, Anjali; Henrickson, Michael; Laskosz, Laura; Duyenhong, Sandy; Spencer, Charles H

    2014-02-10

    Pediatric Rheumatology (PR) training in the US has existed since the 1970's. In the early 1990's, the training was formalized into a three year training program by the American College of Graduate Medical Education (ACGME) and American Board of Pediatrics (ABP). Programs have been evaluated every 5 years by the ACGME to remain credentialed and graduates had to pass a written exam to be certified. There has been no report yet that details not just what training fellows should receive in the 32 US PR training programs but what training the trainees are actually receiving. After a literature search, a survey was constructed by the authors, then reviewed and revised with the help members of the Executive Committee of the Rheumatology Section of the American Academy of Pediatrics (AAP) using the Delphi technique. IRB approval was obtained from the AAP and Nationwide Children's Hospital. The list of fellows was obtained from the ABP and the survey sent out to 81 current fellows or fellows just having finished. One repeat e-mail was sent out. Forty-seven fellows returned the survey by e-mail (58%) with the majority being 3rd year fellows or fellows who had completed their training. The demographics were as expected with females > males and Caucasians> > non-Caucasians. Training appeared quite appropriate in the number of ½ day continuity clinics per week (1-2, 71%), number of patients per clinic (4-5, 60%), inpatient exposure (2-4 inpatients per week, 40%; 5 or greater, 33%), and weekday/weekend call. Fellows attended more didactic activities than required, had ample time for research (54% 21-60/hours per week), and had multiple teaching opportunities. Seventy-seven percent of the trainees presented abstracts at national meetings, 41% had publication. Disease exposure was excellent and joint injection experience sufficient. Most US PR training programs as a whole provide an appropriate training by current ACGME, American College of Rheumatology (ACR), and ABP

  1. Program specialization

    CERN Document Server

    Marlet, Renaud

    2013-01-01

    This book presents the principles and techniques of program specialization - a general method to make programs faster (and possibly smaller) when some inputs can be known in advance. As an illustration, it describes the architecture of Tempo, an offline program specializer for C that can also specialize code at runtime, and provides figures for concrete applications in various domains. Technical details address issues related to program analysis precision, value reification, incomplete program specialization, strategies to exploit specialized program, incremental specialization, and data speci

  2. NCBI nr-aa BLAST: CBRC-DDIS-04-0018 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-DDIS-04-0018 ref|XP_639042.1| Rh-like glycoprotein [Dictyostelium discoideum AX4] gb|AAF63243.1| Rh-...like glycoprotein RhgA [Dictyostelium discoideum] gb|AAP47143.1| Rh-like glycoprotein ...[Dictyostelium discoideum] gb|EAL65679.1| Rh-like glycoprotein [Dictyostelium discoideum AX4] XP_639042.1 0.0 100% ...

  3. ORF Alignment: NC_004337 [GENIUS II[Archive

    Lifescience Database Archive (English)

    Full Text Available NC_004337 gi|24111484 >1q7eA 4 407 11 392 3e-09 ... ref|NP_705994.1| l-carnitine dehy...dratase [Shigella flexneri 2a str. 301] ... gb|AAN41701.1| l-carnitine dehydratase [Shigella ... ... ... flexneri 2a str. 301] ref|NP_835777.1| l-carnitine ... dehydratase [Shigella flexneri 2a str. 2457...T] ... gb|AAP15582.1| l-carnitine dehydratase [Shigella ... flexner

  4. ORF Alignment: NC_004741 [GENIUS II[Archive

    Lifescience Database Archive (English)

    Full Text Available NC_004741 gi|30061606 >1q7eA 4 407 11 392 3e-09 ... ref|NP_705994.1| l-carnitine dehy...dratase [Shigella flexneri 2a str. 301] ... gb|AAN41701.1| l-carnitine dehydratase [Shigella ... ... ... flexneri 2a str. 301] ref|NP_835777.1| l-carnitine ... dehydratase [Shigella flexneri 2a str. 2457...T] ... gb|AAP15582.1| l-carnitine dehydratase [Shigella ... flexner

  5. Gene : CBRC-OSAT-07-0026 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-OSAT-07-0026 Novel 7 B UNKNOWN HCN4_MOUSE 0.006 33% gb|AAP12955.1| hypothetical protein [Oryza sat...iva (japonica cultivar-group)] gb|AAR10872.1| hypothetical protein OSJNBa0008D12.15 [Oryza sat...iva (japonica cultivar-group)] 2e-05 32% gnl|UG|Os#S16395749 Oryza sativa (japonica cultivar-group) cD

  6. Macrophage pro-inflammatory cytokine secretion is enhanced following interaction with autologous platelets

    Directory of Open Access Journals (Sweden)

    Fischer Thomas H

    2010-11-01

    Full Text Available Abstract Background Macrophages are the dominant phagocyte at sites of wound healing and inflammation, and the cellular and acellular debris encountered by macrophages can have profound effects on their inflammatory profile. Following interaction with apoptotic cells, macrophages are known to switch to an anti-inflammatory phenotype. Activated platelets, however, are also a major component of inflammatory lesions and have been proposed to be pro-inflammatory mediators. In the present study, we tested the hypothesis that macrophage interaction with activated platelets results in an inflammatory response that differs from the response following phagocytosis of apoptotic cells. Methods Human monocyte-derived macrophages (hMDMs were co-incubated with autologous activated platelets (AAPs and the platelet-macrophage interaction was examined by electron microscopy and flow cytometry. The cytokines TNF-α, IL-6, and IL-23 were also measured during LPS-activated hMDM co-incubation with AAPs, which was compared to co-incubation with apoptotic lymphocytes. Cytokine secretion was also compared to platelets pre-treated with the gluococorticoid dexamethasone. Results Macrophages trapped and phagocytized AAPs utilizing a mechanism that was significantly inhibited by the scavenger receptor ligand fucoidan. LPS-induced macrophage secretion of TNF-α, IL-6, and IL-23 was inhibited by co-incubation with apoptotic cells, but enhanced by co-incubation with AAPs. The platelet-dependent enhancement of LPS-induced cytokines could be reversed by pre-loading the platelets with the glucocorticoid dexamethasone. Conclusions The interaction of human macrophages with autologous platelets results in scavenger-receptor-mediated platelet uptake and enhancement of LPS-induced cytokines. Therefore, the presence of activated platelets at sites of inflammation may exacerbate pro-inflammatory macrophage activation. The possibility of reversing macrophage activation with

  7. Television viewing in Thai infants and toddlers: impacts to language development and parental perceptions

    OpenAIRE

    Kriweradechachai Suntree; Mo-suwan Ladda; Chuthapisith Jariya; Ruangdaraganon Nichara; Udomsubpayakul Umaporn; Choprapawon Chanpen

    2009-01-01

    Abstract Background Effects of television to language development in infants and toddlers, especially in the Asian children, are inconclusive. This study aimed to (a) study time spent on television in Thai infants and toddlers (age < 2 years), (b) investigate the association between time spent on television (as recommended by the American Academy of Paediatrics (AAP), < 2 hours per day) and language development in Thai 2-year-old children, and (c) explore parental perceptions on television to...

  8. Esiplaanil heli / Harri Slip

    Index Scriptorium Estoniae

    Slip, Harri

    2015-01-01

    Kõrvaklapid hinnaga alla 200 €: AKG Y50BT, Audio-Technica, Beyerdynamic Custom Street, Bose SoundTrue around-ear II, Creative Aurvana Gold, Denon AH-MM200, Focal Spirit One S, Grado SR 80e, JBL Everest V300, Klipsch Reference On Ear, Panasonic RP-HD10, Philips SHB8850NC, Sennheiser HD 25, SMS Audio On-Ear Wired Sport, Sony MDR-100AAP

  9. Reevaluating Reference Ranges of Oxygen Saturation for Healthy Full-term Neonates Using Pulse Oximetry

    Directory of Open Access Journals (Sweden)

    Ying-Chun Lu

    2014-12-01

    Conclusion: The delivery modes did not affect the SpO2 values of full-term healthy neonates. Discrepancies in SpO2 changes in full-term neonates not requiring resuscitation between this study and the AAP/AHA guidelines were significant. SpO2 ranges for each time point within the first 10 minutes after birth should therefore be reevaluated locally.

  10. ORF Alignment: NC_000913 [GENIUS II[Archive

    Lifescience Database Archive (English)

    Full Text Available NC_000913 gi|16129213 >1u07A 1 90 153 242 2e-32 ... ref|NP_707161.2| membrane protein, energy... transducer [Shigella flexneri 2a str. 301] ... gb|AAN42868.2| membrane protein, energy trans...ducer ... [Shigella flexneri 2a str. 301] ref|NP_836946.1| ... membrane protein, energy transd...ucer [Shigella flexneri ... 2a str. 2457T] gb|AAP16753.1| membrane protein, energy

  11. ORF Alignment: NC_002695 [GENIUS II[Archive

    Lifescience Database Archive (English)

    Full Text Available NC_002695 gi|15831006 >1u07A 1 90 153 242 2e-32 ... ref|NP_707161.2| membrane protein, energy... transducer [Shigella flexneri 2a str. 301] ... gb|AAN42868.2| membrane protein, energy trans...ducer ... [Shigella flexneri 2a str. 301] ref|NP_836946.1| ... membrane protein, energy transd...ucer [Shigella flexneri ... 2a str. 2457T] gb|AAP16753.1| membrane protein, energy

  12. ORF Alignment: NC_004741 [GENIUS II[Archive

    Lifescience Database Archive (English)

    Full Text Available NC_004741 gi|30062775 >1u07A 1 90 153 242 2e-32 ... ref|NP_707161.2| membrane protein, energy... transducer [Shigella flexneri 2a str. 301] ... gb|AAN42868.2| membrane protein, energy trans...ducer ... [Shigella flexneri 2a str. 301] ref|NP_836946.1| ... membrane protein, energy transd...ucer [Shigella flexneri ... 2a str. 2457T] gb|AAP16753.1| membrane protein, energy

  13. ORF Alignment: NC_004337 [GENIUS II[Archive

    Lifescience Database Archive (English)

    Full Text Available NC_004337 gi|56479866 >1u07A 1 90 153 242 2e-32 ... ref|NP_707161.2| membrane protein, energy... transducer [Shigella flexneri 2a str. 301] ... gb|AAN42868.2| membrane protein, energy trans...ducer ... [Shigella flexneri 2a str. 301] ref|NP_836946.1| ... membrane protein, energy transd...ucer [Shigella flexneri ... 2a str. 2457T] gb|AAP16753.1| membrane protein, energy

  14. ORF Alignment: NC_004431 [GENIUS II[Archive

    Lifescience Database Archive (English)

    Full Text Available NC_004431 gi|26247582 >1u07A 1 90 153 242 2e-32 ... ref|NP_707161.2| membrane protein, energy... transducer [Shigella flexneri 2a str. 301] ... gb|AAN42868.2| membrane protein, energy trans...ducer ... [Shigella flexneri 2a str. 301] ref|NP_836946.1| ... membrane protein, energy transd...ucer [Shigella flexneri ... 2a str. 2457T] gb|AAP16753.1| membrane protein, energy

  15. A bacterial acyl aminoacyl peptidase couples flexibility and stability as a result of cold adaptation.

    Science.gov (United States)

    Brocca, Stefania; Ferrari, Cristian; Barbiroli, Alberto; Pesce, Alessandra; Lotti, Marina; Nardini, Marco

    2016-12-01

    Life in cold environments requires an overall increase in the flexibility of macromolecular and supramolecular structures to allow biological processes to take place at low temperature. Conformational flexibility supports high catalytic rates of enzymes in the cold but in several cases is also a cause of instability. The three-dimensional structure of the psychrophilic acyl aminoacyl peptidase from Sporosarcina psychrophila (SpAAP) reported in this paper highlights adaptive molecular changes resulting in a fine-tuned trade-off between flexibility and stability. In its functional form SpAAP is a dimer, and an increase in flexibility is achieved through loosening of intersubunit hydrophobic interactions. The release of subunits from the quaternary structure is hindered by an 'arm exchange' mechanism, in which a tiny structural element at the N terminus of one subunit inserts into the other subunit. Mutants lacking the 'arm' are monomeric, inactive and highly prone to aggregation. Another feature of SpAAP cold adaptation is the enlargement of the tunnel connecting the exterior of the protein with the active site. Such a wide channel might compensate for the reduced molecular motions occurring in the cold and allow easy and direct access of substrates to the catalytic site, rendering transient movements between domains unnecessary. Thus, cold-adapted SpAAP has developed a molecular strategy unique within this group of proteins: it is able to enhance the flexibility of each functional unit while still preserving sufficient stability. Structural data are available in the Protein Data Bank under the accession number 5L8S. © 2016 Federation of European Biochemical Societies.

  16. AcEST: DK953767 [AcEST

    Lifescience Database Archive (English)

    Full Text Available T... 30 5.6 sp|A7XYJ6|SOBPB_DANRE Sine oculis-binding protein homolog OS=Dan... 29 7.3 sp|Q9BZ72|PITM2_HUMAN...PLP--RATPQP 1032 Query: 51 QLP 43 P Sbjct: 1033 AAP 1035 >sp|A7XYJ6|SOBPB_DANRE Sine oculis-binding protein

  17. Aard en oorsprong van bipedalisme by primate

    OpenAIRE

    P. A. J. Ryke

    1987-01-01

    Die verskille en ooreenkomste wat ape en mense kenmerk, is die onvermydelike en voorspelbare gevolg van afstamming van ’n gemeenskaplike voorouer. ’n Belangrike vraag om in hierdie verband te vra, is wat tot verandering van kwadrupedalisme na bipedalisme, waarskynlik ten tye van die divergering van aap- en hominiedstamlyne, aanleiding gegee het? Of het dit voor die splitsing geskied? Wat is die voordele en nadele van bipedale voortbeweging? ’n Evaluering van die oorsprong van bipedalisme verg...

  18. Gene : CBRC-PVAM-01-0362 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-PVAM-01-0362 Novel UN A Family 2 (B) receptors VIPR2_HUMAN 0.0 79% gb|AAP36781.1| Homo sapiens va...soactive intestinal peptide receptor 2 [synthetic construct] gb|AAX43622.1| vasoactive in...testinal peptide receptor 2 [synthetic construct] gb|AAX43623.1| vasoactive intestinal peptide receptor 2 [s...HLNLFLSFILRAISVLVKDEVLYSSSSTLHCPDQPSSWVGCKLSLVVFQYCTMANFYWLLVEGLYLHTLLVAVLGPRRHLLAYLLIGWGVPTVCTAAWTVARLFVEDT...GCWDSNEHSVPWGLLRWAFGEVNFVLFISIVRILLQKLTSPDIGGNEQSQYKRLTKSTLLLIPLFGVHYVVFAVVPMGISSKYQLTFELCVGSFQGLVVA

  19. NCBI nr-aa BLAST: CBRC-CBRE-01-0099 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available -group)] gb|AAG13395.1|AF283006_1 cold acclimation protein WCOR413-like protein [Oryza sativa (japonica cult...ivar-group)] gb|AAP50941.1| putative cold acclimation protein [Oryza sativa (japonica cultivar-group)] gb|AAR87336.1| cold acclima...ultivar-group)] gb|ABF99064.1| cold acclimation protein COR413-PM1, putative, expressed [Oryza sativa (japon

  20. NCBI nr-aa BLAST: CBRC-CFAM-17-0004 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-CFAM-17-0004 gb|AAB00481.1| apolipoprotein B-100 precursor gb|AAP72970.1| apolipoprotein... B (including Ag(x) antigen) [Homo sapiens] gb|EAX00801.1| apolipoprotein B (including Ag(x) antig...en), isoform CRA_a [Homo sapiens] gb|EAX00803.1| apolipoprotein B (including Ag(x) antigen), isoform CRA_a [Homo sapiens] AAB00481.1 0.0 78% ...

  1. Role of Symbiotic Auxotrophy in the Rhizobium-Legume Symbioses

    OpenAIRE

    Jurgen Prell; Alexandre Bourdès; Shalini Kumar; Emma Lodwig; Arthur Hosie; Seonag Kinghorn; James White; Philip Poole

    2010-01-01

    Background Rhizobium leguminosarum bv. viciae mutants unable to transport branched-chain amino acids via the two main amino acid ABC transport complexes AapJQMP and BraDEFGC produce a nitrogen starvation phenotype when inoculated on pea (Pisum sativum) plants [1], [2]. Bacteroids in indeterminate pea nodules have reduced abundance and a lower chromosome number. They reduce transcription of pathways for branched-chain amino acid biosynthesis and become dependent on their provision by the host....

  2. NCBI nr-aa BLAST: CBRC-DYAK-02-0082 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-DYAK-02-0082 ref|NP_611979.1| painless CG15860-PA [Drosophila melanogaster] sp...|Q9W0Y6|PAIN_DROME Transient receptor potential cation channel protein painless gb|AAF47293.1| CG15860-PA [D...rosophila melanogaster] gb|AAP03646.1| painless [Drosophila melanogaster] gb|AAR99141.1| RE03641p [Drosophila melanogaster] NP_611979.1 0.0 88% ...

  3. Gene : CBRC-DYAK-02-0082 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-DYAK-02-0082 Novel 2R C UNKNOWN PAIN_DROME 0.0 88% ref|NP_611979.1| painless C...G15860-PA [Drosophila melanogaster] sp|Q9W0Y6|PAIN_DROME Transient receptor potential cation channel protein painless... gb|AAF47293.1| CG15860-PA [Drosophila melanogaster] gb|AAP03646.1| painless [Drosophila melanogast

  4. NCBI nr-aa BLAST: CBRC-DSIM-02-0084 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-DSIM-02-0084 ref|NP_611979.1| painless CG15860-PA [Drosophila melanogaster] sp...|Q9W0Y6|PAIN_DROME Transient receptor potential cation channel protein painless gb|AAF47293.1| CG15860-PA [D...rosophila melanogaster] gb|AAP03646.1| painless [Drosophila melanogaster] gb|AAR99141.1| RE03641p [Drosophila melanogaster] NP_611979.1 0.0 93% ...

  5. Gene : CBRC-DSIM-02-0084 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-DSIM-02-0084 Novel 2R C UNKNOWN PAIN_DROME 0.0 93% ref|NP_611979.1| painless C...G15860-PA [Drosophila melanogaster] sp|Q9W0Y6|PAIN_DROME Transient receptor potential cation channel protein painless... gb|AAF47293.1| CG15860-PA [Drosophila melanogaster] gb|AAP03646.1| painless [Drosophila melanogast

  6. NCBI nr-aa BLAST: CBRC-AGAM-03-0028 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-AGAM-03-0028 ref|NP_611979.1| painless CG15860-PA [Drosophila melanogaster] sp...|Q9W0Y6|PAIN_DROME Transient receptor potential cation channel protein painless gb|AAF47293.1| CG15860-PA [D...rosophila melanogaster] gb|AAP03646.1| painless [Drosophila melanogaster] gb|AAR99141.1| RE03641p [Drosophila melanogaster] NP_611979.1 7e-56 29% ...

  7. Cadmium-induced oxidative stress in potato tuber

    OpenAIRE

    Andrzej Stroiński; Monika Kozłowska

    2014-01-01

    Short-term treatment of tuber discs of potato (Solanum tuberosum L.) with cadmium chloride elevated the concentration of active oxygen species (.O-2, H202) and activated the antioxidative system. Two cultivars, Bintje and Bzura, susceptible and tolerant, respectively, to cadmium were examined. In more tolerant, control tissues the activity of ascorbic acid peroxidase (AAP) and catalase (CAT) was higher than in the sensitive ones. During first hours of stress, the inhibition of superoxide dism...

  8. Periapical fluid RANKL and IL-8 are differentially regulated in pulpitis and apical periodontitis.

    Science.gov (United States)

    Rechenberg, Dan-K; Bostanci, Nagihan; Zehnder, Matthias; Belibasakis, Georgios N

    2014-09-01

    The dental pulp space can become infected due to a breach in the surrounding hard tissues. This leads to inflammation of the pulp (pulpitis), soft tissue breakdown, and finally to bone loss around the root apex (apical periodontitis). The succession of the molecular events leading to apical periodontitis is currently not known. The main inflammatory mediator associated with neutrophil chemotaxis is interleukin-8 (IL-8), and with bone resorption the dyad of receptor activator of NF-κB ligand (RANKL) and osteoprotegerin (OPG). The levels of RANKL, OPG and IL-8 were studied in periapical tissue fluid of human teeth (n = 48) diagnosed with symptomatic irreversible pulpitis (SIP) and asymptomatic apical periodontitis (AAP). SIP represents the starting point, and AAP an established steady state of the disease. Periapical tissue fluid samples were collected using paper points and then evaluated using enzyme-linked immunosorbent assays (ELISAs). Target protein levels per case were calibrated against the corresponding total protein content, as determined fluorometrically. RANKL was expressed at significantly higher levels in SIP compared to AAP (P < 0.05), whereas OPG was under the detection limit in most samples. In contrast, IL-8 levels were significantly lower in SIP compared to AAP (P < 0.05). Spearman's correlation analysis between RANKL and IL-8 revealed a significantly (P < 0.05) negative correlation between the two measures (rho = -.44). The results of this study suggest that, in the development of apical periodontitis, periapical bone resorption signaling, as determined by RANKL, occurs prior to inflammatory cell recruitment signaling, as determined by IL-8. Copyright © 2014 Elsevier Ltd. All rights reserved.

  9. A Reassessment of the SIDS Back to Sleep Campaign

    Directory of Open Access Journals (Sweden)

    Ralph Pelligra

    2005-01-01

    Full Text Available The Back to Sleep Campaign was initiated in 1994 to implement the American Academy of Pediatrics' (AAP recommendation that infants be placed in the nonprone sleeping position to reduce the risk of the Sudden Infant Death Syndrome (SIDS. This paper offers a challenge to the Back to Sleep Campaign (BTSC from two perspectives: (1 the questionable validity of SIDS mortality and risk statistics, and (2 the BTSC as human experimentation rather than as confirmed preventive therapy.

  10. Risk of ischemic stroke associated with the use of antipsychotic drugs in elderly patients: a retrospective cohort study in Korea.

    Directory of Open Access Journals (Sweden)

    Ju-Young Shin

    Full Text Available Strong concerns have been raised about whether the risk of ischemic stroke differs between conventional antipsychotics (CAPs and atypical antipsychotics (AAPs. This study compared the risk of ischemic stroke in elderly patients taking CAPs and AAPs.We conducted a retrospective cohort study of 71,584 elderly patients who were newly prescribed the CAPs (haloperidol or chlorpromazine and those prescribed the AAPs (risperidone, quetiapine, or olanzapine. We used the National Claims Database from the Health Insurance Review and Assessment Service (HIRA from January 1, 2006 to December 31, 2009. Incident cases for ischemic stroke (ICD-10, I63 were identified. The hazard ratios (HR for AAPs, CAPs, and for each antipsychotic were calculated using multivariable Cox regression models, with risperidone as a reference.Among a total of 71,584 patients, 24,668 patients were on risperidone, 15,860 patients on quetiapine, 3,888 patients on olanzapine, 19,564 patients on haloperidol, and 7,604 patients on chlorpromazine. A substantially higher risk was observed with chlorpromazine (HR = 3.47, 95% CI, 1.97-5.38, which was followed by haloperidol (HR = 2.43, 95% CI, 1.18-3.14, quetiapine (HR = 1.23, 95% CI, 0.78-2.12, and olanzapine (HR = 1.12, 95% CI, 0.59-2.75. Patients who were prescribed chlorpromazine for longer than 150 days showed a higher risk (HR = 3.60, 95% CI, 1.83-6.02 than those who took it for a shorter period of time.A much greater risk of ischemic stroke was observed in patients who used chlorpromazine and haloperidol compared to risperidone. The evidence suggested that there is a strong need to exercise caution while prescribing these agents to the elderly in light of severe adverse events with atypical antipsychotics.

  11. Literacy promotion: an essential component of primary care pediatric practice.

    Science.gov (United States)

    High, Pamela C; Klass, Perri

    2014-08-01

    Reading regularly with young children stimulates optimal patterns of brain development and strengthens parent-child relationships at a critical time in child development, which, in turn, builds language, literacy, and social-emotional skills that last a lifetime. Pediatric providers have a unique opportunity to encourage parents to engage in this important and enjoyable activity with their children beginning in infancy. Research has revealed that parents listen and children learn as a result of literacy promotion by pediatricians, which provides a practical and evidence-based opportunity to support early brain development in primary care practice. The American Academy of Pediatrics (AAP) recommends that pediatric providers promote early literacy development for children beginning in infancy and continuing at least until the age of kindergarten entry by (1) advising all parents that reading aloud with young children can enhance parent-child relationships and prepare young minds to learn language and early literacy skills; (2) counseling all parents about developmentally appropriate shared-reading activities that are enjoyable for children and their parents and offer language-rich exposure to books, pictures, and the written word; (3) providing developmentally appropriate books given at health supervision visits for all high-risk, low-income young children; (4) using a robust spectrum of options to support and promote these efforts; and (5) partnering with other child advocates to influence national messaging and policies that support and promote these key early shared-reading experiences. The AAP supports federal and state funding for children's books to be provided at pediatric health supervision visits to children at high risk living at or near the poverty threshold and the integration of literacy promotion, an essential component of pediatric primary care, into pediatric resident education. This policy statement is supported by the AAP technical report "School

  12. Hypertonic Saline for the Treatment of Bronchiolitis in Infants and Young Children: A Critical Review of the Literature

    OpenAIRE

    Baron, Jeffrey; El-Chaar, Gladys

    2016-01-01

    Bronchiolitis, an infection of the lower respiratory tract, is the leading cause of infant and child hospitalization in the United States. Therapeutic options for management of bronchiolitis are limited. Hypertonic saline inhalation therapy has been studied in numerous clinical trials with mixed results. In 2014, the American Academy of Pediatrics (AAP) published updated guidelines on the diagnosis and management of bronchiolitis, which include new recommendations on the use of hypertonic sal...

  13. In vitro interference by acetaminophen, aspirin, and metamizole in serum measurements of glucose, urea, and creatinine.

    Science.gov (United States)

    Luna-Záizar, Hilda; Virgen-Montelongo, María; Cortez-Álvarez, Cesar R; Ruiz-Quezada, Sandra L; Escutia-Gutiérrez, Raymundo; García-Lemus, Cuauhtémoc R; Mendizabal-Ruiz, Adriana P

    2015-05-01

    Here we aimed to investigate the in vitro effects of three analgesic-antipyretic drugs frequently used in clinical practice in Mexico - acetaminophen (AAP), aspirin (ASA) and metamizole (MMZ) - on serum measurements of glucose, urea, and creatinine. Each analyte was measured in a base-serum pool spiked with the drugs at subtherapeutic, therapeutic, and toxic doses. Serum glucose and urea were measured using the hexokinase/G-6PDH and urease/GLDH kinetic assays, respectively. Serum creatinine (SCr) was measured with a Jaffe procedure based on the alkaline-picrate reaction and with an enzymatic dry-chemistry system. Measurements were carried out in IL-Monarch and Vitros DT60-II analyzers, respectively. Data were analyzed by the difference-paired interference test and by ANOVA. By the kinetic Jaffe/Monarch procedure, we found positive interference by the drugs on the SCr measurements and by only ASA for urea measurement. For creatinine measurements, the total errors (TEs) were 22-51%, 18-105%, and 15-26% for AAP, ASA, and MMZ respectively, while for urea measurement the TE was 16-21% for ASA. A negative interference by MMZ on SCr (TE=-47%), but no-interference for AAP or ASA, were found via the enzymatic/DT60-II system. In vitro positive interference induced by AAP, ASA, and MMZ (via the alkaline-picrate reaction), or negative interference by MMZ (via a dry-chemistry system), on the SCr measurements highlights the importance of investigating all possible sources of variation that may alter the accuracy of the laboratory tests, in order to provide useful results for making medical decisions for optimal patient care. Copyright © 2015 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

  14. Download this PDF file

    African Journals Online (AJOL)

    USER

    The complexes are diamagnetic (no paramagnetic broadening observed in the 1H NMR spectra) and stable for long periods in solution and in the solid state. Crystal structure of [Re(3-aap)Cl3(PPh3)2•ЅMe2CO]. The structure of complex 2 is shown in Figure 1. The monomeric neutral octahedral complex is formally a ...

  15. NCBI nr-aa BLAST: CBRC-DDIS-06-0034 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-DDIS-06-0034 ref|NP_566644.1| WD-40 repeat family protein / mitotic checkpoint... protein, putative [Arabidopsis thaliana] dbj|BAB02543.1| mitotic checkpoint protein [Arabidopsis thaliana] ...gb|AAM64953.1| mitotic checkpoint protein, putative [Arabidopsis thaliana] gb|AAO42274.1| putative mitotic checkpoint... protein [Arabidopsis thaliana] gb|AAP04137.1| putative mitotic checkpoint protein [Arabidopsis thaliana] NP_566644.1 2e-70 48% ...

  16. Compliance of Parenting Magazines Advertisements with American Academy of Pediatrics Recommendations

    Science.gov (United States)

    Pitt, Michael B.; Berger, Jennifer N.; Sheehan, Karen M.

    2016-01-01

    This study examined 3218 advertisements from the two parenting magazines with highest circulation in the United States. The authors compared each advertisement for a product for use by children, against all the published recommendations of the American Academy of Pediatrics (AAP) on topics such as toy safety, helmet use, age-defined choking hazards, infant sleep safety, and others. Any advertisement with images or products which went against a published AAP recommendation was deemed as non-adherence and was categorized according to the statement it contradicted. Nearly one in six (15.7%) of the advertisements contained example(s) of non-adherence to AAP recommendations, with twelve categories of offense represented. Categories ranked by overall share from most to least include: non-Food and Drug Administration (FDA) approved medical treatments, age-defined choking hazards, vitamins, cold medicine, formula, oral care, screen time, toy/playground safety, infant sleep, nutrition, water safety, and fall risk. Given that repeated exposure to messages in advertisements has been associated with changes in health decision-making, and parents often turn to parenting magazines for advice and ideas regarding their children, the publishers might consider screening the content in order to prevent confusing and potentially dangerous messages from being disseminated in the media. PMID:27809284

  17. Compliance of Parenting Magazines Advertisements with American Academy of Pediatrics Recommendations

    Directory of Open Access Journals (Sweden)

    Michael B. Pitt

    2016-11-01

    Full Text Available This study examined 3218 advertisements from the two parenting magazines with highest circulation in the United States. The authors compared each advertisement for a product for use by children, against all the published recommendations of the American Academy of Pediatrics (AAP on topics such as toy safety, helmet use, age-defined choking hazards, infant sleep safety, and others. Any advertisement with images or products which went against a published AAP recommendation was deemed as non-adherence and was categorized according to the statement it contradicted. Nearly one in six (15.7% of the advertisements contained example(s of non-adherence to AAP recommendations, with twelve categories of offense represented. Categories ranked by overall share from most to least include: non-Food and Drug Administration (FDA approved medical treatments, age-defined choking hazards, vitamins, cold medicine, formula, oral care, screen time, toy/playground safety, infant sleep, nutrition, water safety, and fall risk. Given that repeated exposure to messages in advertisements has been associated with changes in health decision-making, and parents often turn to parenting magazines for advice and ideas regarding their children, the publishers might consider screening the content in order to prevent confusing and potentially dangerous messages from being disseminated in the media.

  18. Family Socioeconomic Status Moderates Associations Between Television Viewing and School Readiness Skills.

    Science.gov (United States)

    Ribner, Andrew; Fitzpatrick, Caroline; Blair, Clancy

    2017-04-01

    We examined whether the negative relation between television viewing that exceeds the recommendations of the American Academy of Pediatrics (AAP) and school readiness varied by family income. Data were collected from 807 children from diverse backgrounds. Parents reported hours of television viewing, as well as family income. Children were assessed using measures of math, knowledge of letters and words, and executive function (EF). Television viewing was negatively associated with math and EF but not with letter and word knowledge. An interaction between television viewing and family income indicated that the effect of television viewing in excess of the AAP recommended maximum had negative associations with math and EF that increased as a linear function of family income. Furthermore, EF partially mediated the relation between television viewing and math. Television viewing is negatively associated with children's school readiness skills, and this association increased as family income decreased. Active efforts to reinforce AAP guidelines to limit the amount of television children watch should be made, especially for children from middle- to lower-income families.

  19. Hypertonic Saline for the Treatment of Bronchiolitis in Infants and Young Children: A Critical Review of the Literature

    Science.gov (United States)

    Baron, Jeffrey

    2016-01-01

    Bronchiolitis, an infection of the lower respiratory tract, is the leading cause of infant and child hospitalization in the United States. Therapeutic options for management of bronchiolitis are limited. Hypertonic saline inhalation therapy has been studied in numerous clinical trials with mixed results. In 2014, the American Academy of Pediatrics (AAP) published updated guidelines on the diagnosis and management of bronchiolitis, which include new recommendations on the use of hypertonic saline. We reviewed all published clinical trials mentioned in the 2014 AAP guidelines, as well as additional trials published since the guidelines, and critically evaluated each trial to determine efficacy, safety, and expectations of hypertonic saline inhalation therapy. A total of 2682 infants were studied over the course of 22 clinical trials. Nine trials were carried out in the outpatient/clinic/emergency department and 13 in the inpatient setting. We agree with the AAP guidelines regarding the recommendation to use nebulized hypertonic saline for infants hospitalized with bronchiolitis, with the expectation of reducing bronchiolitis scores and length of stay when it is expected to last more than 72 hours. However, we also believe there might be an advantage for hypertonic saline in reducing admission rates from the emergency department, based on close examination of the results of recent trials. This review also highlights important gaps in the available literature that need to be addressed in order to define the role of inhaled hypertonic saline therapy. PMID:26997926

  20. Barriers to Pediatricians’ Adherence to American Academy of Pediatrics Oral Health Referral Guidelines: North Carolina General Dentists’ Opinions

    Science.gov (United States)

    Long, C. Marshall; Quinonez, Rocio B.; Rozier, R. Gary; Kranz, Ashley M.; Lee, Jessica Y.

    2015-01-01

    Purpose The purposes of this study were to: (1) assess knowledge, attitudes, and behaviors of North Carolina general dentists (GDs) regarding American Academy of Pediatrics (AAP) dental referral guidelines; and (2) determine factors that influence pediatricians’ ability to comply with AAP guidelines. Methods One thousand GDs were surveyed to determine barriers toward acceptance of physician referrals of infants and toddlers. The primary outcome using ordered logistic regression was GDs’ acceptance of children described in five case scenarios, with different levels of risk and oral health status. Results GDs believed pediatricians should refer patients at risk for caries to a dentist. While 61 to 75 percent of GDs were willing to accept low caries risk referrals of infants and toddlers, only 35 percent would accept referrals when caries was present. Predictors of referral acceptance were correct knowledge about AAP guidelines (OR=2.0, 95%CI=1.2-3.3), confidence in pro- viding preventive care to infants and toddlers (OR=2.6, 95%CI=1.3-4.9), and agreement that parents see importance in dental referrals (OR=2.1, 95% CI=1.2-3.6). Conclusions This study identified factors influencing acceptance of pediatrician referrals for the age one dental visit among North Carolina GDs and highlighted challenges pediatricians face in referring young children for dental care. PMID:25197996

  1. Barriers to pediatricians' adherence to American Academy of Pediatrics oral health referral guidelines: North Carolina general dentists' opinions.

    Science.gov (United States)

    Long, C Marshall; Quinonez, Rocio B; Rozier, R Gary; Kranz, Ashley M; Lee, Jessica Y

    2014-01-01

    The purposes of this study were to: (1) assess knowledge, attitudes, and behaviors of North Carolina general dentists (GDs) regarding American Academy of Pediatrics (AAP) dental referral guidelines; and (2) determine factors that influence pediatricians' ability to comply with AAP guidelines. One thousand GDs were surveyed to determine barriers toward acceptance of physician referrals of infants and toddlers. The primary outcome using ordered logistic regression was GDs' acceptance of children described in five case scenarios, with different levels of risk and oral health status. GDs believed pediatricians should refer patients at risk for caries to a dentist. While 61 to 75 percent of GDs were willing to accept low caries risk referrals of infants and toddlers, only 35 percent would accept referrals when caries was present. Predictors of referral acceptance were correct knowledge about AAP guidelines (OR=2.0, 95%CI=1.2-3.3), confidence in providing preventive care to infants and toddlers (OR=2.6, 95%CI=1.3-4.9), and agreement that parents see importance in dental referrals (OR=2.1, 95% CI=1.2-3.6). This study identified factors influencing acceptance of pediatrician referrals for the age one dental visit among North Carolina GDs and highlighted challenges pediatricians face in referring young children for dental care.

  2. The Med-Peds Hospitalist Workforce: Results From the American Academy of Pediatrics Workforce Survey.

    Science.gov (United States)

    Donnelly, Michael J; Lubrano, Lauren; Radabaugh, Carrie L; Lukela, Michael P; Friedland, Allen R; Ruch-Ross, Holly S

    2015-11-01

    There is no published literature about the med-peds hospitalist workforce, physicians dually trained in internal medicine and pediatrics. Our objective was to analyze this subset of physicians by using data from the American Academy of Pediatrics (AAP) workforce survey to assess practice patterns and workforce demographics. We hypothesized that demographic differences exist between hospitalists and nonhospitalists. The AAP surveyed med-peds physicians from the Society of Hospital Medicine and the AAP to define workforce demographics and patterns of practice. We compared self-identified hospitalists with nonhospitalist physicians on multiple characteristics. Almost one-half of the hospitalists self-identified as being both primary care physicians and hospitalists; we therefore also compared the physicians self-identifying as being both primary care physicians and hospitalists with those who identified themselves solely as hospitalists. Of 1321 respondents, 297 physicians (22.4%) self-reported practicing as hospitalists. Hospitalists were more likely than nonhospitalists to have been practicing50 hours per week (PMed-peds hospitalists are more likely to be newer to practice and be employed by a health care organization than nonhospitalists and to report satisfaction that their training sufficiently prepared them to see adults and children in practice. Copyright © 2015 by the American Academy of Pediatrics.

  3. Fabrication of multiwalled carbon nanotube-surfactant modified sensor for the direct determination of toxic drug 4-aminoantipyrine

    Directory of Open Access Journals (Sweden)

    Jayant I. Gowda

    2015-08-01

    Full Text Available A multi-walled carbon nanotube (MWCNT-cetyltrimethylammonium bromide (CTAB surfactant composite modified glassy carbon electrode (GCE was developed as a novel system for the determination of 4-aminoantipyrine(AAP. The oxidation process was irreversible over the pH range studied and exhibited a diffusion controlled behavior. All experimental parameters were optimized. The combination of MWCNT-CTAB endows the biosensor with large surface area, good biological compatibility, electricity and stability, high selectivity and sensitivity. MWCNT-CTAB/GCE electrode gave a linear response for AAP from 5.0×10−9 to 4.0×10−8 M with a detection limit of 1.63×10−10 M. The modified electrode showed good selectivity against interfering species and also exhibited good reproducibility. The present electrochemical sensor based on the MWCNT-CTAB/GCE electrode was applied to the determination of AAP in real samples. Keywords: Voltammetry, Modified electrode, Diffusion controlled, 4-aminoantipyrine, Pharmacokinetic study

  4. Cultivation of Aquincola tertiaricarbonis L108 on the fuel oxygenate intermediate tert-butyl alcohol induces aerobic anoxygenic photosynthesis at extremely low feeding rates.

    Science.gov (United States)

    Rohwerder, Thore; Müller, Roland H; Weichler, M Teresa; Schuster, Judith; Hübschmann, Thomas; Müller, Susann; Harms, Hauke

    2013-10-01

    Aerobic anoxygenic photosynthesis (AAP) is found in an increasing number of proteobacterial strains thriving in ecosystems ranging from extremely oligotrophic to eutrophic. Here, we have investigated whether the fuel oxygenate-degrading betaproteobacterium Aquincola tertiaricarbonis L108 can use AAP to compensate kinetic limitations at low heterotrophic substrate fluxes. In a fermenter experiment with complete biomass retention and also during chemostat cultivation, strain L108 was challenged with extremely low substrate feeding rates of tert-butyl alcohol (TBA), an intermediate of methyl tert-butyl ether (MTBE). Interestingly, formation of photosynthetic pigments, identified as bacteriochlorophyll a and spirilloxanthin, was only induced in growing cells at TBA feeding rates less than or equal to maintenance requirements observed under energy excess conditions. Growth continued at rates between 0.001 and 0.002 h(-1) even when the TBA feed was decreased to values close to 30 % of this maintenance rate. Partial sequencing of genomic DNA of strain L108 revealed a bacteriochlorophyll synthesis gene cluster (bchFNBHL) and photosynthesis regulator genes (ppsR and ppaA) typically found in AAP and other photosynthetic proteobacteria. The usage of light as auxiliary energy source enabling evolution of efficient degradation pathways for kinetically limited heterotrophic substrates and for lowering the threshold substrate concentration Smin at which growth becomes zero is discussed.

  5. Synthesis, characterization, antimicrobial screening and computational studies of 4-[3-(4-methoxy-phenyl)-allylideneamino]-1,5-dimethyl-2-phenyl-1,2-dihydro-pyrazol-3-one

    Science.gov (United States)

    Obasi, L. N.; Kaior, G. U.; Rhyman, L.; Alswaidan, Ibrahim A.; Fun, Hoong-Kun; Ramasami, P.

    2016-09-01

    The Schiff base, 4-[3-(4-methoxy-phenyl)-allylideneamino]-1,5-dimethyl-2-phenyl-1,2-dihydro-pyrazol-3-one (TPMC/AAP) was synthesized by the condensation of 4-aminoantipyrine (4-amino-1,5-dimethyl-2-phenylpyrazole-3-one) and trans-para-methoxycinnamaldehyde (trans-3,4-methoxyphenyl-2-propenal) in dry methanol at 75 °C. The compound was characterized using elemental microanalysis, IR, NMR, UV spectroscopies and single-crystal X-ray crystallography. The X-ray structure determination shows that the Schiff base, (TPMC/AAP) is orthorhombic with the Pbca space group. The anti-microbial screening of the compound was carried out with Escherichia coli, Bacillus subtillis, Staphylococcus aureus, Pseudemonas aeruginosa, Candida albicans and Aspergillus niger using agar well diffusion method. The Schiff base possesses significant antimicrobial activity. The minimum inhibitory concentration (MIC) of the compound was also determined and the activity was compared with that of conventional drugs ciprofloxacin and ketoconazole. The compound (TPMC/AAP) showed varying activity against the cultured bacteria and fungi used. To complement the experimental data, density functional theory (DFT) was used to have deeper understanding into the molecular parameters and infrared spectra of the compound.

  6. Compliance of Parenting Magazines Advertisements with American Academy of Pediatrics Recommendations.

    Science.gov (United States)

    Pitt, Michael B; Berger, Jennifer N; Sheehan, Karen M

    2016-11-01

    This study examined 3218 advertisements from the two parenting magazines with highest circulation in the United States. The authors compared each advertisement for a product for use by children, against all the published recommendations of the American Academy of Pediatrics (AAP) on topics such as toy safety, helmet use, age-defined choking hazards, infant sleep safety, and others. Any advertisement with images or products which went against a published AAP recommendation was deemed as non-adherence and was categorized according to the statement it contradicted. Nearly one in six (15.7%) of the advertisements contained example(s) of non-adherence to AAP recommendations, with twelve categories of offense represented. Categories ranked by overall share from most to least include: non-Food and Drug Administration (FDA) approved medical treatments, age-defined choking hazards, vitamins, cold medicine, formula, oral care, screen time, toy/playground safety, infant sleep, nutrition, water safety, and fall risk. Given that repeated exposure to messages in advertisements has been associated with changes in health decision-making, and parents often turn to parenting magazines for advice and ideas regarding their children, the publishers might consider screening the content in order to prevent confusing and potentially dangerous messages from being disseminated in the media.

  7. Impact of utilizing pharmacy students as workforce for Hawai'i Asthma Friendly Pharmacy Project.

    Science.gov (United States)

    Ma, Carolyn S; Nett, Blythe; Kishaba, Gregg; Gomez, Lara

    2015-02-01

    A partnership was formed between the University of Hawai'i at Hilo Daniel K. Inouye College of Pharmacy (DKICP) and the Department of Health to carry out the Hawai'i Asthma Friendly Pharmacy Project (HAFPP), which utilizes pharmacy students as a workforce to administer Asthma Control Tests™ (ACT), and provide Asthma Action Plans (AAP) and inhaler technique education. Evaluation of data from a pilot project in 2008 with first and second year students prompted more intensive training in therapeutics, inhaler medication training, and communication techniques. Data collection began when two classes of students were first and second year students and continued until the students became fourth year students in their advanced experiential ambulatory care clinic and retail community pharmacy rotations. Patients seen included pediatric (32%) and adult (68%) aged individuals. Hawai'i County was the most common geographic site (50%) and most sites were retail pharmacies (72%). Administered ACT surveys (N=96) yielded a mean score of 19.64 (SD +/-3.89). In addition, 12% of patients had received previous ACT, and 47% had previous AAPs. Approximately 83% of patients received an additional intervention of AAP and inhaler education with 73% of these patients able to demonstrate back proper inhaler technique. Project challenges included timing of student training, revising curriculum and logistics of scheduling students to ensure consistent access to patients.

  8. A Longitudinal Study of Pediatricians Early in Their Careers: PLACES.

    Science.gov (United States)

    Frintner, Mary Pat; Cull, William L; Byrne, Bobbi J; Freed, Gary L; Katakam, Shesha K; Leslie, Laurel K; Miller, Ashley A; Starmer, Amy J; Olson, Lynn M

    2015-08-01

    The American Academy of Pediatrics (AAP) launched the Pediatrician Life and Career Experience Study (PLACES), a longitudinal study that tracks the personal and professional experiences of early career pediatricians, in 2012. We used a multipronged approach to develop the study methodology and survey domains and items, including review of existing literature and qualitative research with the target population. We chose to include 2 cohorts of US pediatricians on the basis of residency graduation dates, including 1 group who were several years out of residency (2002-2004 Residency Graduates Cohort) and a second group who recently graduated from residency at study launch (2009-2011 Residency Graduates Cohort). Recruitment into PLACES was a 2-stage process: (1) random sample recruitment from the target population and completion of an initial intake survey and (2) completion of the first Annual Survey by pediatricians who responded positively to stage 1. Overall, 41.2% of pediatricians randomly selected to participate in PLACES indicated positive interest in the study by completing intake surveys; of this group, 1804 (93.7%) completed the first Annual Survey and were considered enrolled in PLACES. Participants were more likely to be female, AAP members, and graduates of US medical schools compared with the target sample; weights were calculated to adjust for these differences. We will survey PLACES pediatricians 2 times per year. PLACES data will allow the AAP to examine career and life choices and transitions experienced by early-career pediatricians. Copyright © 2015 by the American Academy of Pediatrics.

  9. Hypertonic Saline for the Treatment of Bronchiolitis in Infants and Young Children: A Critical Review of the Literature.

    Science.gov (United States)

    Baron, Jeffrey; El-Chaar, Gladys

    2016-01-01

    Bronchiolitis, an infection of the lower respiratory tract, is the leading cause of infant and child hospitalization in the United States. Therapeutic options for management of bronchiolitis are limited. Hypertonic saline inhalation therapy has been studied in numerous clinical trials with mixed results. In 2014, the American Academy of Pediatrics (AAP) published updated guidelines on the diagnosis and management of bronchiolitis, which include new recommendations on the use of hypertonic saline. We reviewed all published clinical trials mentioned in the 2014 AAP guidelines, as well as additional trials published since the guidelines, and critically evaluated each trial to determine efficacy, safety, and expectations of hypertonic saline inhalation therapy. A total of 2682 infants were studied over the course of 22 clinical trials. Nine trials were carried out in the outpatient/clinic/emergency department and 13 in the inpatient setting. We agree with the AAP guidelines regarding the recommendation to use nebulized hypertonic saline for infants hospitalized with bronchiolitis, with the expectation of reducing bronchiolitis scores and length of stay when it is expected to last more than 72 hours. However, we also believe there might be an advantage for hypertonic saline in reducing admission rates from the emergency department, based on close examination of the results of recent trials. This review also highlights important gaps in the available literature that need to be addressed in order to define the role of inhaled hypertonic saline therapy.

  10. Premedication Use Before Nonemergent Intubation in the Newborn Infant.

    Science.gov (United States)

    Muniraman, Hemananda K; Yaari, Jonathan; Hand, Ivan

    2015-07-01

    In 2010, an American Academy of Pediatrics (AAP) clinical report recommended that except for emergent situations, premedication should be used for all endotracheal intubations in newborns. The purpose of this study is to ascertain the current practice of premedication before elective intubation. An online, survey-based questionnaire on the practice of premedication before nonemergent intubations was distributed via e-mail to neonatologists who are members of the Perinatal Section of the AAP. Although 72% of respondents believed premedication should be used in nonemergent intubations, only 34% of the respondents report frequently premedicating before intubation with significant variation among the neonatal units (46% among level 4 units and 27% in level 3 and 2 units) p = 0.000. About 44% of respondents report having a written protocol or guideline on premedication which significantly correlated with the use of premedication (62% in level 4, 33% in level 3, and 16% in level 2 units), p = 0.000. Despite a recent AAP clinical report recommending the use of premedication before nonemergent endotracheal intubation, only one-third of neonatologists report frequent use of premedication and less than half of the institutions have a written protocol on premedication. Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

  11. Nonemergency Acute Care: When It's Not the Medical Home.

    Science.gov (United States)

    Conners, Gregory P; Kressly, Susan J; Perrin, James M; Richerson, Julia E; Sankrithi, Usha M

    2017-05-01

    The American Academy of Pediatrics (AAP) affirms that the optimal location for children to receive care for acute, nonemergency health concerns is the medical home. The medical home is characterized by the AAP as a care model that "must be accessible, family centered, continuous, comprehensive, coordinated, compassionate, and culturally effective." However, some children and families use acute care services outside the medical home because there is a perceived or real benefit related to accessibility, convenience, or cost of care. Examples of such acute care entities include urgent care facilities, retail-based clinics, and commercial telemedicine services. Children deserve high-quality, appropriate, and safe acute care services wherever they access the health care system, with timely and complete communication with the medical home, to ensure coordinated and continuous care. Treatment of children under established, new, and evolving practice arrangements in acute care entities should adhere to the core principles of continuity of care and communication, best practices within a defined scope of services, pediatric-trained staff, safe transitions of care, and continuous improvement. In support of the medical home, the AAP urges stakeholders, including payers, to avoid any incentives (eg, reduced copays) that encourage visits to external entities for acute issues as a preference over the medical home. Copyright © 2017 by the American Academy of Pediatrics.

  12. Everything in Moderation: Moderate Use of Screens Unassociated with Child Behavior Problems.

    Science.gov (United States)

    Ferguson, Christopher J

    2017-12-01

    The impact of children's use of "screen" media including television and computer games, continues to be debated. The American Academy of Pediatrics (AAP) until recently recommended a relatively restrictive screen time diet of 2 h or less for most youth. A representative correlational sample of youth were assessed for links between screen time and risky behavioral outcomes. Data collection occurred in 2013 conducted by the State of Florida. Use of screens that was moderately high, in excess of the AAP's former recommendations, but not excessive (1 SD or higher than average), was not associated with delinquency, risky behaviors, sexual behaviors, substance abuse, reduced grades or mental health problems. Even excessive screen use (1 SD or higher) was only weakly associated with negative outcomes related to delinquency, grades and depression only, and at levels unlikely to be practically significant. Results conceptually replicate those of Przybylski (2014) with a US sample for depression and delinquency as outcomes. Moderate use of screens, though in excess of the AAP's historical recommendations, are unassociated with problem outcomes. Excessive use of screens is only weakly associated with negative outcomes, and only those related to depression and delinquency as well as reduced grades, but not risky driving, substance use, risky sex or disordered eating. Although an "everything in moderation" message when discussing screen time with parents may be most productive, results do not support a strong focus on screen time as a preventative measure for youth problem behaviors.

  13. Determination of total phenols in environmental wastewater by flow-injection analysis with a biamperometric detector

    Energy Technology Data Exchange (ETDEWEB)

    Zhao, Chuan; Song, Jun-feng; Zhang, Jun-cai [Institute of Analytical Science, Northwest University, Xi' an 710069 (China)

    2002-10-01

    A flow injection (FI) method with a biamperometric detector, based on the biamperometry for an irreversible redox couple, is described for the determination of phenols in environmental wastewater. The method relies on coupling of the oxidation of phenols at one platinum-wire electrode with the reduction of MnO{sub 4}{sup -} at another platinum wire electrode to enable biamperometric detection with an applied potential difference of 0 V. The linear dynamic range for the dependence of current on phenol concentration was from 1.0 x 10{sup -6} to 1.0 x 10{sup -4} mol L{sup -1}, with a detection limit of 4.0 x 10{sup -7} mol L{sup -1} (signal-to-noise ratio, S/N=3). In comparison with the 4-aminoantipyrine (4-AAP) standard method and the 3-methyl-2-benzothiazoline hydrazone (MBTH) method the proposed method can be used to detect many para-substituted phenols that do not react with 4-AAP and MBTH, and response factors are higher for most of the phenols tested. The method, which is simple, economic, and rapid (180 samples h{sup -1}), has been applied to the analysis of four wastewater samples. The results obtained were compared with those from 4-AAP method. The recoveries obtained by adding phenol standards to samples ranged from 94.3 to 105.2% with a standard deviation of 3.6%. (orig.)

  14. Determination of total phenols in environmental wastewater by flow-injection analysis with a biamperometric detector.

    Science.gov (United States)

    Zhao, Chuan; Song, Jun-Feng; Zhang, Jun-Cai

    2002-10-01

    A flow injection (FI) method with a biamperometric detector, based on the biamperometry for an irreversible redox couple, is described for the determination of phenols in environmental wastewater. The method relies on coupling of the oxidation of phenols at one platinum-wire electrode with the reduction of MnO4- at another platinum wire electrode to enable biamperometric detection with an applied potential difference of 0 V. The linear dynamic range for the dependence of current on phenol concentration was from 1.0 x 10(-6) to 1.0 x 10(-4) mol L(-1), with a detection limit of 4.0 x 10(-7) mol L(-1) (signal-to-noise ratio, S/N=3). In comparison with the 4-aminoantipyrine (4-AAP) standard method and the 3-methyl-2-benzothiazoline hydrazone (MBTH) method the proposed method can be used to detect many para-substituted phenols that do not react with 4-AAP and MBTH, and response factors are higher for most of the phenols tested. The method, which is simple, economic, and rapid (180 samples h(-1)), has been applied to the analysis of four wastewater samples. The results obtained were compared with those from 4-AAP method. The recoveries obtained by adding phenol standards to samples ranged from 94.3 to 105.2% with a standard deviation of 3.6%.

  15. Biofilm formation of ica operon-positive Staphylococcus epidermidis from different sources.

    Science.gov (United States)

    Argudín, Maria Angeles; Vanderhaeghen, Wannes; Vandendriessche, Stien; Vandecandelaere, Ilse; Denis, Olivier; Coenye, Tom; Butaye, Patrick

    2015-12-01

    Information on the prevalence of biofilm-related factors (PIA, Bhp, Aap, Embp) in Staphylococcus epidermidis of animal origin is scarce. In this study, 263 S. epidermidis isolates of diverse origin (animal, farmers, patients, and laboratory staff) were investigated for the presence of the ica operon (icaRADBC). The icaRADBC-positive isolates were further characterized by means of biofilm formation, presence of other biofilm-related genes, antimicrobial resistance, and population structure. Of all isolates, 28.5% (n = 75) were icaRADBC-positive, including 16.5% of animal origin, 29.1% farmer isolates, and 44.6% hospital-associated isolates (including patients and laboratory staff isolates). Most icaRADBC-positive isolates carried embp (n = 73), aap (n = 57), bhp (n = 22), and IS256 (n = 29). Statistical differences were found between animal and patient isolates for the presence of icaRADBC, bhp, and aap. No statistically significant relation was found between the presence of one or more genes and the level of biofilm formation. Most icaRADBC-positive isolates belonged to the clonal complex 5 (formerly 2) and most sequence types corresponded to types previously observed in community and nosocomial S. epidermidis populations. Although the prevalence of S. epidermidis in the nasal cavity of bovines and poultry is low, some isolates belong to STs related to ica-positive clinical strains. © 2015 APMIS. Published by John Wiley & Sons Ltd.

  16. Chapter Oral Health Advocates: A Nationwide Model for Pediatrician Peer Education and Advocacy about Oral Health

    Directory of Open Access Journals (Sweden)

    Charlotte W. Lewis

    2013-01-01

    Full Text Available Objective. (1 To describe an innovative program training US pediatricians to be Chapter Oral Health Advocates (COHAs. (2 To provide insight into COHAs’ experiences disseminating oral health knowledge to fellow pediatricians. Patients and Methods. Interviews with 40 COHAs who responded to an email request, from a total of 64 (62% response. Transcripts were analyzed for common themes about COHA activities, facilitators, and barriers. Results. COHAs reported positive experiences at the AAP oral health training program. A subset of academic COHAs focused on legislative activity and another on resident education about oral health. Residents had an easier time adopting oral health activities while practicing pediatricians cited time constraints. COHAs provided insights into policy, barriers, and facilitators for incorporating oral health into practice. Conclusions. This report identifies factors influencing pediatricians’ adoption of oral health care into practice. COHAs reported successes in training peers on integrating oral health into pediatric practice, identified opportunities and challenges to oral health implementation in primary care, and reported issues about the state of children’s oral health in their communities. With ongoing support, the COHA program has a potential to improve access to preventive oral health services in the Medical Home and to increase referrals to a Dental Home.

  17. Parenting Programs

    Directory of Open Access Journals (Sweden)

    Juan Carlos Martín-Quintana

    2010-01-01

    Full Text Available This paper was aimed at emphasizing the importance of using parenting programs to promote parental competences. There is a need for this support taking into account the complexity of the parenting task in our modern societies. Following the European recommendation on positive parenting, those parenting programs are considered important measures to support parents in their educational role. Forward, several generations of parenting programs at the international context were briefly described and some examples of programs within the national context, as well. This paper provides some reflection on three models of parental education, and shows the results of an experiential parenting programs addressed to parents in psychosocial risk situation in two Spanish communities. A new program “Crecer felices en familia”, still in the implementation phase, was also described. As a conclusion, the paper emphasized the importance of evaluating programs in order to know more about their efficacy and to improve the way of implementation in real settings.

  18. Acquisition, Replication and Inoculation of Candidatus Liberibacter asiaticus following Various Acquisition Periods on Huanglongbing-Infected Citrus by Nymphs and Adults of the Asian Citrus Psyllid.

    Science.gov (United States)

    Ammar, El-Desouky; Ramos, John E; Hall, David G; Dawson, William O; Shatters, Robert G

    2016-01-01

    The Asian citrus psyllid, Diaphorina citri (Hemiptera: Liviidae), is the primary vector of Candidatus Liberibacter asiaticus (Las) implicated as causative agent of citrus huanglongbing (citrus greening), currently the most serious citrus disease worldwide. Las is transmitted by D. citri in a persistent-circulative manner, but the question of replication of this bacterium in its psyllid vector has not been resolved. Thus, we studied the effects of the acquisition access period (AAP) by nymphs and adults of D. citri on Las acquisition, multiplication and inoculation/transmission. D. citri nymphs or adults (previously non-exposed to Las) were caged on Las-infected citrus plants for an AAP of 1, 7 or 14 days. These 'Las-exposed' psyllids were then transferred weekly to healthy citrus or orange jasmine plants, and sampled via quantitative polymerase chain reaction (qPCR) analysis 1-42 days post-first access to diseased plants (padp); all tested nymphs became adults 7-14 days padp. Our results indicate that following 1 or 7 day AAP as nymphs 49-59% of Las-exposed psyllids became Las-infected (qPCR-positive), whereas only 8-29% of the psyllids were infected following 1-14 day AAP as adults. Q-PCR analysis also indicated that Las titer in the Las-exposed psyllids (relative to that of the psyllid S20 ribosomal protein gene) was: 1) significantly higher, and increasing at a faster rate, following Las acquisition as nymphs compared to that following Las acquisition as adults; 2) higher as post-acquisition time of psyllids on healthy plants increased reaching a peak at 14-28 days padp for nymphs and 21-35 days padp for adults, with Las titer decreasing or fluctuating after that; 3) higher with longer AAP on infected plants, especially with acquisition as adults. Our results strongly suggest that Las multiplies in both nymphs and adults of D. citri but attains much higher levels in a shorter period of time post-acquisition when acquired by nymphs than when acquired by adults

  19. Acquisition, Replication and Inoculation of Candidatus Liberibacter asiaticus following Various Acquisition Periods on Huanglongbing-Infected Citrus by Nymphs and Adults of the Asian Citrus Psyllid.

    Directory of Open Access Journals (Sweden)

    El-Desouky Ammar

    Full Text Available The Asian citrus psyllid, Diaphorina citri (Hemiptera: Liviidae, is the primary vector of Candidatus Liberibacter asiaticus (Las implicated as causative agent of citrus huanglongbing (citrus greening, currently the most serious citrus disease worldwide. Las is transmitted by D. citri in a persistent-circulative manner, but the question of replication of this bacterium in its psyllid vector has not been resolved. Thus, we studied the effects of the acquisition access period (AAP by nymphs and adults of D. citri on Las acquisition, multiplication and inoculation/transmission. D. citri nymphs or adults (previously non-exposed to Las were caged on Las-infected citrus plants for an AAP of 1, 7 or 14 days. These 'Las-exposed' psyllids were then transferred weekly to healthy citrus or orange jasmine plants, and sampled via quantitative polymerase chain reaction (qPCR analysis 1-42 days post-first access to diseased plants (padp; all tested nymphs became adults 7-14 days padp. Our results indicate that following 1 or 7 day AAP as nymphs 49-59% of Las-exposed psyllids became Las-infected (qPCR-positive, whereas only 8-29% of the psyllids were infected following 1-14 day AAP as adults. Q-PCR analysis also indicated that Las titer in the Las-exposed psyllids (relative to that of the psyllid S20 ribosomal protein gene was: 1 significantly higher, and increasing at a faster rate, following Las acquisition as nymphs compared to that following Las acquisition as adults; 2 higher as post-acquisition time of psyllids on healthy plants increased reaching a peak at 14-28 days padp for nymphs and 21-35 days padp for adults, with Las titer decreasing or fluctuating after that; 3 higher with longer AAP on infected plants, especially with acquisition as adults. Our results strongly suggest that Las multiplies in both nymphs and adults of D. citri but attains much higher levels in a shorter period of time post-acquisition when acquired by nymphs than when acquired by

  20. Association Study of Val66Met Polymorphism in Brain-Derived Neurotrophic Factor Gene with Clozapine-Induced Metabolic Syndrome: Preliminary Results

    Science.gov (United States)

    Zhang, Yi; Chen, Meijuan; Wu, Zhiguo; Chen, Jun; Yu, Shunying; Fang, Yiru; Zhang, Chen

    2013-01-01

    The prevalence of the metabolic syndrome (MetS) is higher among patients receiving atypical antipsychotics (AAPs) treatment, and even among AAPs, treatment with clozapine has been shown to be associated with a higher long-term incidence rate of MetS. Likewise, brain-derived neurotrophic factor (BDNF) deficiency has been reported to result in metabolic traits, such as increased food intake, hyperphagia and obesity, etc. In this study, we hypothesized that a functional polymorphism (Val66Met) in the BDNF gene may confer susceptibility to clozapine-induced MetS, potentially in a sex-specific manner, since an interaction between Val66Met polymorphism and sex was observed in our previous studies. A total of 199 schizophrenia patients being treated with clozapine were divided into two groups, MetS and non-MetS, based on the diagnostic criteria of the National Cholesterol Education Program's Adult Treatment Panel III. We genotyped the Val66Met polymorphism, and measured the serum levels of fasting glucose (GLU), triglyceride (TG) and high density lipoprotein cholesterol (HDL). There was a trend indicating a significant association between the homozygous Met/Met genotype and MetS in male patients (OR = 2.39; 95% CI: 1.05–5.41; p = 0.039; corrected p = 0.078). Among the six risk factors listed in the ATPIII criteria, we found a significant association between fasting GLU levels and Val66Met polymorphism in males (p = 0.005; corrected p = 0.03), but not in females (p = 0.65). Post-hoc analysis in males revealed that the Met/Met carriers had significant higher levels of fasting GLU than those with Val/Val or Val/Met genotypes (p = 0.007; corrected p = 0.042 and p = 0.002; corrected p = 0.012, respectively). In conclusion, we observed a weak association between the Val66Met polymorphism and clozapine-induced MetS in a sex-specific manner. While preliminary, such findings prompt further, large-scale longitudinal studies to replicate

  1. Association study of Val66Met polymorphism in brain-derived neurotrophic factor gene with clozapine-induced metabolic syndrome: preliminary results.

    Directory of Open Access Journals (Sweden)

    Yi Zhang

    Full Text Available The prevalence of the metabolic syndrome (MetS is higher among patients receiving atypical antipsychotics (AAPs treatment, and even among AAPs, treatment with clozapine has been shown to be associated with a higher long-term incidence rate of MetS. Likewise, brain-derived neurotrophic factor (BDNF deficiency has been reported to result in metabolic traits, such as increased food intake, hyperphagia and obesity, etc. In this study, we hypothesized that a functional polymorphism (Val66Met in the BDNF gene may confer susceptibility to clozapine-induced MetS, potentially in a sex-specific manner, since an interaction between Val66Met polymorphism and sex was observed in our previous studies. A total of 199 schizophrenia patients being treated with clozapine were divided into two groups, MetS and non-MetS, based on the diagnostic criteria of the National Cholesterol Education Program's Adult Treatment Panel III. We genotyped the Val66Met polymorphism, and measured the serum levels of fasting glucose (GLU, triglyceride (TG and high density lipoprotein cholesterol (HDL. There was a trend indicating a significant association between the homozygous Met/Met genotype and MetS in male patients (OR = 2.39; 95% CI: 1.05-5.41; p = 0.039; corrected p = 0.078. Among the six risk factors listed in the ATPIII criteria, we found a significant association between fasting GLU levels and Val66Met polymorphism in males (p = 0.005; corrected p = 0.03, but not in females (p = 0.65. Post-hoc analysis in males revealed that the Met/Met carriers had significant higher levels of fasting GLU than those with Val/Val or Val/Met genotypes (p = 0.007; corrected p = 0.042 and p = 0.002; corrected p = 0.012, respectively. In conclusion, we observed a weak association between the Val66Met polymorphism and clozapine-induced MetS in a sex-specific manner. While preliminary, such findings prompt further, large-scale longitudinal studies to

  2. Material Programming

    DEFF Research Database (Denmark)

    Vallgårda, Anna; Boer, Laurens; Tsaknaki, Vasiliki

    2017-01-01

    , and color, but additionally being capable of sensing, actuating, and computing. Indeed, computers will not be things in and by themselves, but embedded into the materials that make up our surroundings. This also means that the way we interact with computers and the way we program them, will change....... Consequently we ask what the practice of programming and giving form to such materials would be like? How would we be able to familiarize ourselves with the dynamics of these materials and their different combinations of cause and effect? Which tools would we need and what would they look like? Will we program...... these computational composites through external computers and then transfer the code them, or will the programming happen closer to the materials? In this feature we outline a new research program that floats between imagined futures and the development of a material programming practice....

  3. Effective Programming

    DEFF Research Database (Denmark)

    Frost, Jacob

    To investigate the use of VTLoE as a basis for formal derivation of functional programs with effects. As a part of the process, a number of issues central to effective formal programming are considered. In particular it is considered how to develop a proof system suitable for pratical reasoning......, how to implement this system in the generic proof assistant Isabelle and finally how to apply the logic and the implementation to programming....

  4. Program Fullerene

    DEFF Research Database (Denmark)

    Wirz, Lukas; Peter, Schwerdtfeger,; Avery, James Emil

    2013-01-01

    Fullerene (Version 4.4), is a general purpose open-source program that can generate any fullerene isomer, perform topological and graph theoretical analysis, as well as calculate a number of physical and chemical properties. The program creates symmetric planar drawings of the fullerene graph......-Fowler, and Brinkmann-Fowler vertex insertions. The program is written in standard Fortran and C++, and can easily be installed on a Linux or UNIX environment....

  5. Programming Interactivity

    CERN Document Server

    Noble, Joshua

    2009-01-01

    Make cool stuff. If you're a designer or artist without a lot of programming experience, this book will teach you to work with 2D and 3D graphics, sound, physical interaction, and electronic circuitry to create all sorts of interesting and compelling experiences -- online and off. Programming Interactivity explains programming and electrical engineering basics, and introduces three freely available tools created specifically for artists and designers: Processing, a Java-based programming language and environment for building projects on the desktop, Web, or mobile phonesArduino, a system t

  6. Programming F#

    CERN Document Server

    Smith, Chris

    2009-01-01

    Why learn F#? This multi-paradigm language not only offers you an enormous productivity boost through functional programming, it also lets you develop applications using your existing object-oriented and imperative programming skills. With Programming F#, you'll quickly discover the many advantages of Microsoft's new language, which includes access to all the great tools and libraries of the .NET platform. Learn how to reap the benefits of functional programming for your next project -- whether it's quantitative computing, large-scale data exploration, or even a pursuit of your own. With th

  7. A statewide assessment of tuberculin skin testing of preschool children enrolled in medicaid managed care.

    Science.gov (United States)

    Vivier, Patrick M; O'haire, Christen; Alario, Anthony J; Simon, Peter; Leddy, Tricia; Peter, Georges

    2006-03-01

    This study examined tuberculosis screening among preschool children enrolled in a statewide Medicaid managed care program. A random sample of 2,000 was selected from 19 to 35 month old children who were continuously enrolled in Rhode Island's Medicaid managed care program for 1 year. Sociodemographic data were obtained from computerized administrative databases. Medical record audits were performed to obtain the dates and results of tuberculosis tests. Data from the medical record audits were available for 1,988 of the study children. For 1,215 of the study children (1,215/1,988 = 61%) a tuberculin skin test had been performed, but a reading was only documented for 736 children (60% of children who received a tuberculin skin test) and only one child tested positive (0.1%). A majority of preschool children in this population in which the prevalence of risk factors for tuberculosis is likely to be relatively high did have a tuberculosis test performed. However, in many cases the tuberculin skin test was either not read or the results not documented. The low rate of positivity is consistent with current AAP guidelines for selective tuberculin skin testing.

  8. Transitioning HIV-Positive Adolescents to Adult Care: Lessons Learned From Twelve Adolescent Medicine Clinics.

    Science.gov (United States)

    Tanner, Amanda E; Philbin, Morgan M; DuVal, Anna; Ellen, Jonathan; Kapogiannis, Bill; Fortenberry, J Dennis

    2016-01-01

    To maximize positive health outcomes for youth with HIV as they transition from youth to adult care, clinical staff need strategies and protocols to help youth maintain clinic engagement and medication adherence. Accordingly, this paper describe transition processes across twelve clinics within the Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) to provide lessons learned and inform the development of transition protocols to improve health outcomes as youth shift from adolescent to adult HIV care. During a large multi-method Care Initiative program evaluation, three annual visits were completed at each site from 2010-2012 and conducted 174 semi-structured interviews with clinical and program staff (baseline n=64, year 1 n=56, year 2=54). The results underscore the value of adhering to recent American Academy of Pediatrics (AAP) transition recommendations, including: developing formal transition protocols, preparing youth for transition, facilitating youth's connection to the adult clinic, and identifying necessary strategies for transition evaluation. Transitioning youth with HIV involves targeting individual-, provider-, and system-level factors. Acknowledging and addressing key barriers is essential for developing streamlined, comprehensive, and context-specific transition protocols. Adolescent and adult clinic involvement in transition is essential to reduce service fragmentation, provide coordinated and continuous care, and support individual and community level health. Copyright © 2016 Elsevier Inc. All rights reserved.

  9. Computer Programs.

    Science.gov (United States)

    Anderson, Tiffoni

    This module provides information on development and use of a Material Safety Data Sheet (MSDS) software program that seeks to link literacy skills education, safety training, and human-centered design. Section 1 discusses the development of the software program that helps workers understand the MSDSs that accompany the chemicals with which they…

  10. Choreographic Programming

    DEFF Research Database (Denmark)

    Montesi, Fabrizio

    , as they offer a concise view of the message flows enacted by a system. For this reason, in the last decade choreographies have been used in the development of programming languages, giving rise to a programming paradigm that in this dissertation we refer to as Choreographic Programming. Recent studies show...... endpoint described in a choreography can then be automatically generated, ensuring that such implementations are safe by construction. However, current formal models for choreographies do not deal with critical aspects of distributed programming, such as asynchrony, mobility, modularity, and multiparty...... sessions; it remains thus unclear whether choreographies can still guarantee safety when dealing with such nontrivial features. This PhD dissertation argues for the suitability of choreographic programming as a paradigm for the development of safe distributed systems. We proceed by investigating its...

  11. Programming Python

    CERN Document Server

    Lutz, Mark

    2011-01-01

    If you've mastered Python's fundamentals, you're ready to start using it to get real work done. Programming Python will show you how, with in-depth tutorials on the language's primary application domains: system administration, GUIs, and the Web. You'll also explore how Python is used in databases, networking, front-end scripting layers, text processing, and more. This book focuses on commonly used tools and libraries to give you a comprehensive understanding of Python's many roles in practical, real-world programming. You'll learn language syntax and programming techniques in a clear and co

  12. Programming Python

    National Research Council Canada - National Science Library

    Lutz, Mark

    2006-01-01

    ... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 3 3 8 9 15 17 20 22 2. A Sneak Preview "Programming Python: The Short Story" The Task Step 1: Representing Records Step 2: Storing Records Persistently Step 3...

  13. Linear programming

    CERN Document Server

    Solow, Daniel

    2014-01-01

    This text covers the basic theory and computation for a first course in linear programming, including substantial material on mathematical proof techniques and sophisticated computation methods. Includes Appendix on using Excel. 1984 edition.

  14. Graduating med-peds residents' interest in part-time employment.

    Science.gov (United States)

    Fix, Amy L; Kaelber, David C; Melgar, Thomas A; Chamberlain, John; Cull, William; Robbins, Brett W

    2011-01-01

    As part-time work is becoming more popular among the primary care specialties, we examined the demographic descriptors of med-peds residents seeking and finding part-time employment upon completion of residency training. As part of the 2006 annual American Academy of Pediatrics (AAP) Graduating Med-Peds Residents Survey, we surveyed the graduating residents of all med-peds programs about their interest in and plans for part-time employment. A total of 199 (60%) of the residents responded. Of the resident respondents applying for nonfellowship jobs, 19% sought part-time positions and 10% actually accepted a part-time position. Female residents were significantly more likely than male residents to apply for part-time jobs (26% vs. 7%, P = .034). Sixty percent of female residents immediately seeking work and 58% of those going on to fellowship reported an interest in arranging a part-time or reduced-hours position at some point in the next 5 years. Part-time employment among med-peds residents applying for nonfellowship positions after graduation is similar to the current incidence of part-time employment in other fields of primary care. A much higher percentage of med-peds residents are interested in arranging part-time work within 5 years after graduation. This strong interest in part-time work has many implications for the primary care workforce. Copyright © 2011 Academic Pediatric Association. Published by Elsevier Inc. All rights reserved.

  15. Assessment of active play, inactivity and perceived barriers in an inner city neighborhood.

    Science.gov (United States)

    Kottyan, Gregg; Kottyan, Leah; Edwards, Nicholas M; Unaka, Ndidi I

    2014-06-01

    Avondale, a disadvantaged neighborhood in Cincinnati, lags behind on a number of indicators of child well-being. Childhood obesity has become increasingly prevalent, as one-third of Avondale's kindergarteners are obese or overweight. The study objective was to determine perceptions of the quantity of and obstacles to childhood physical activity in the Avondale community. Caregivers of children from two elementary schools were surveyed to assess their child's physical activity and barriers to being active. Three hundred and forty surveys were returned out of 1,047 for a response rate of 32%. On school days, 41% of caregivers reported that their children spent more than 2 h watching television, playing video games, or spending time on the computer. While over half of respondents reported that their children get more than 2 h of physical activity on school days, 14% of children were reported to be physically active less than 1 h per day. Caregivers identified violence, cost of extracurricular activities, and lack of organized activities as barriers to their child's physical activity. The overwhelming majority of caregivers expressed interest in a program to make local playgrounds safer. In conclusion, children in Avondale are not participating in enough physical activity and are exposed to more screen time than is recommended by the AAP. Safety concerns were identified as a critical barrier to address in future advocacy efforts in this community. This project represents an important step toward increasing the physical activity of children in Avondale and engaging the local community.

  16. Army Programs: Army Energy Program

    Science.gov (United States)

    1997-02-03

    the Energy Program. o Expands the responsibilities of the Assistant Chief of Staff for Installation Management (para 1-4). o Includes ridesharing as...not been highlighted. Summary. This regulation establishes poli- cies, procedures, and responsibilities for the Army Energy Program. Applicability ...Energy Technology Service (FETS) • 3–13, page 6 Energy Surveys • 3–14, page 6 Army Energy Awareness Seminars • 3–15, page 6 Army ridesharing • 3–16

  17. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Program Commission on Cancer National Accreditation Program for Breast Centers National Cancer Database National Accreditation Program for Rectal Cancer Oncology Medical Home Accreditation Program Stereotactic Breast Biopsy Accreditation Program Cancer Programs Staff Information Children's ...

  18. Programming Algol

    CERN Document Server

    Malcolme-Lawes, D J

    2014-01-01

    Programming - ALGOL describes the basics of computer programming using Algol. Commands that could be added to Algol and could increase its scope are described, including multiplication and division and the use of brackets. The idea of labeling or naming a command is also explained, along with a command allowing two alternative results. Most of the important features of Algol syntax are discussed, and examples of compound statements (that is, sets of commands enclosed by a begin ... end command) are given.Comprised of 11 chapters, this book begins with an introduction to the digital computer an

  19. Programming Interactivity

    CERN Document Server

    Noble, Joshua

    2012-01-01

    Ready to create rich interactive experiences with your artwork, designs, or prototypes? This is the ideal place to start. With this hands-on guide, you'll explore several themes in interactive art and design-including 3D graphics, sound, physical interaction, computer vision, and geolocation-and learn the basic programming and electronics concepts you need to implement them. No previous experience is necessary. You'll get a complete introduction to three free tools created specifically for artists and designers: the Processing programming language, the Arduino microcontroller, and the openFr

  20. ICD programming

    OpenAIRE

    Biffi, Mauro

    2014-01-01

    Background: Appropriate ICD programming is the key to prevent inappropriate shock delivery, that is closely associated to a negative patients' outcome. Methods: Review of the literature on ICD therapy to generate ICD programmings that can be applied to the broad population of ICD and CRT-D carriers. Results: Arrhythmia detection should occur with a detection time ranging 9″–12″ in the VF zone, and 15″–60″ in the VT zone. Discriminator should be applied at least up to 200 bpm. ATP therap...

  1. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Safety Conference Registry Login SCR Training and Testing Cancer Cancer Programs Cancer Programs Overview of Cancer Programs Cancer Programs News American Joint Committee on ...

  2. Program Proposal

    Science.gov (United States)

    Baskas, Richard S.

    2012-01-01

    A study was conducted to determine if a deficiency, or learning gap, existed in a particular working environment. To determine if an assessment was to be conducted, a program proposal would need to be developed to explore this situation. In order for a particular environment to react and grow with other environments, it must be able to take on…

  3. Sprego Programming

    Directory of Open Access Journals (Sweden)

    Maria Csernoch

    2015-02-01

    Full Text Available Spreadsheet management is a border-land between office applications and programming, however, it is rather communicated that spreadsheet is nothing more than an easily handled fun piece. Consequently, the complexity of spreadsheet handling, the unprepared end-users, their problem solving abilities and approaches do not match. To overcome these problems we have developed and introduced Sprego (Spreadsheet Lego. Sprego is a simplified functional programming language in spreadsheet environment, and such as can be used both as introductory language and the language of end-user programmers. The essence of Sprego is that we use as few and simple functions as possible and based on these functions build multilevel formulas. With this approach, similar to high level programming, we are able solve advanced problems, developing algorithmic skills, computational thinking. The advantage of Sprego is the simplicity of the language, when the emphasis is not on the coding but on the problem. Beyond that spreadsheets would provide real life problems with authentic data and tables which students are more interested in than the artificial environment and semi-authentic problems of high level programming languages.

  4. Constraint Programming versus Mathematical Programming

    DEFF Research Database (Denmark)

    Hansen, Jesper

    2003-01-01

    Constraint Logic Programming (CLP) is a relatively new technique from the 80's with origins in Computer Science and Artificial Intelligence. Lately, much research have been focused on ways of using CLP within the paradigm of Operations Research (OR) and vice versa. The purpose of this paper...

  5. Linear programming

    CERN Document Server

    Karloff, Howard

    1991-01-01

    To this reviewer’s knowledge, this is the first book accessible to the upper division undergraduate or beginning graduate student that surveys linear programming from the Simplex Method…via the Ellipsoid algorithm to Karmarkar’s algorithm. Moreover, its point of view is algorithmic and thus it provides both a history and a case history of work in complexity theory. The presentation is admirable; Karloff's style is informal (even humorous at times) without sacrificing anything necessary for understanding. Diagrams (including horizontal brackets that group terms) aid in providing clarity. The end-of-chapter notes are helpful...Recommended highly for acquisition, since it is not only a textbook, but can also be used for independent reading and study. —Choice Reviews The reader will be well served by reading the monograph from cover to cover. The author succeeds in providing a concise, readable, understandable introduction to modern linear programming. —Mathematics of Computing This is a textbook intend...

  6. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Inspiring Quality Initiative Resources Continuous Quality Improvement ACS Clinical Scholars in Residence AHRQ Safety Program for ISCR ... Advocacy Efforts Cancer Liaison Program Cancer Programs Conference Clinical Research Program Commission on Cancer National Accreditation Program ...

  7. Programming Pig

    CERN Document Server

    Gates, Alan

    2011-01-01

    This guide is an ideal learning tool and reference for Apache Pig, the open source engine for executing parallel data flows on Hadoop. With Pig, you can batch-process data without having to create a full-fledged application-making it easy for you to experiment with new datasets. Programming Pig introduces new users to Pig, and provides experienced users with comprehensive coverage on key features such as the Pig Latin scripting language, the Grunt shell, and User Defined Functions (UDFs) for extending Pig. If you need to analyze terabytes of data, this book shows you how to do it efficiently

  8. Programming Razor

    CERN Document Server

    Chadwick, Jess

    2011-01-01

    Take Razor for a test drive and discover first hand how this scripting syntax simplifies the way you create dynamic, data-driven websites. With this concise guide, you'll work with Razor syntax by building example websites with Microsoft WebMatrix and ASP.NET MVC. You'll quickly learn how Razor lets you combine code and content in a fluid and expressive manner on Windows-based servers. Programming Razor also explores components of the Razor API, and shows you how Razor templates are turned into rendered HTML. By the end of this book, you'll be able to create Razor-based websites with custom

  9. Geothermal Technologies Program Overview - Peer Review Program

    Energy Technology Data Exchange (ETDEWEB)

    Milliken, JoAnn [Office of Energy Efficiency and Renewable Energy (EERE), Washington, DC (United States)

    2011-06-06

    This Geothermal Technologies Program presentation was delivered on June 6, 2011 at a Program Peer Review meeting. It contains annual budget, Recovery Act, funding opportunities, upcoming program activities, and more.

  10. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Accreditation Program Stereotactic Breast Biopsy Accreditation Program Cancer Programs Staff Information Children's Surgery Children's Surgery Children's Surgery Children's Surgery Verification ...

  11. Annotated Answer Set Programming

    OpenAIRE

    Straccia, Umberto

    2005-01-01

    We present Annotated Answer Set Programming, that extends the ex pressive power of disjunctive logic programming with annotation terms, taken from the generalized annotated logic programming framework.

  12. Functional Python programming

    CERN Document Server

    Lott, Steven

    2015-01-01

    This book is for developers who want to use Python to write programs that lean heavily on functional programming design patterns. You should be comfortable with Python programming, but no knowledge of functional programming paradigms is needed.

  13. Human Reliability Program Overview

    Energy Technology Data Exchange (ETDEWEB)

    Bodin, Michael

    2012-09-25

    This presentation covers the high points of the Human Reliability Program, including certification/decertification, critical positions, due process, organizational structure, program components, personnel security, an overview of the US DOE reliability program, retirees and academia, and security program integration.

  14. Vehicle Technologies Program Overview

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2006-09-05

    Overview of the Vehicle Technologies Program including external assessment and market view; internal assessment, program history and progress; program justification and federal role; program vision, mission, approach, strategic goals, outputs, and outcomes; and performance goals.

  15. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Quality Improvement Program About Standards Apply Participant Use Data File (PUF) Resources & FAQs Find a MBSAQIP Center ... Programs BleedingControl.org Trauma Quality Programs National Trauma Data Bank Trauma Quality Improvement Program Mentoring for Excellence ...

  16. Ostomy Home Skills Program

    Medline Plus

    Full Text Available ... Overview of Cancer Programs Cancer Programs News American Joint Committee on Cancer Cancer Advocacy Efforts Cancer Liaison ... Validation Programs Accredited Education Institutes CME Accreditation CME Joint Providership Program Verification of Knowledge and Skills Resources ...

  17. Effects of Matrix Composition on Detection Threshold Estimates for Methyl Anthranilate and 2-Aminoacetophenone

    Directory of Open Access Journals (Sweden)

    Demetra M. Perry

    2016-05-01

    Full Text Available Conceptually, a detection threshold represents the lowest concentration at which an individual or a group of individuals can reliably perceive a given stimulus, with a commonly used operational definition of 50% performance above chance. Estimated detection thresholds (DTs, however, are often reported in the literature with little attention given to the matrix in which the stimuli were evaluated. Here, we highlight the influence of matrix effects on DTs for two odor-active compounds commonly found in Vitis Labrusca wines. Differences in orthonasal DTs for methyl anthranilate (MA and 2-aminoacetophenone (2AAP in water, a model wine system, and wine were demonstrated using a within-subject design and forced choice (i.e., criterion free psychophysical methods. Six sample triads, each containing two blanks and one spiked sample, were presented to participants with the instructions to choose the “different” sample, and this was repeated in different matrices (water, model wine, and wine. The estimated DTs for both compounds were significantly lower in water versus the model wine system and wine. This finding recapitulates the strong need to carefully consider the nature of the delivery matrix when determining and comparing threshold estimates across studies. Additionally, data from prior reports have suggested DTs for MA and 2AAP may differ by two orders of magnitude in spite of their structural similarity. We failed to confirm this difference here: although 2AAP thresholds were somewhat lower than MA thresholds, differences were much smaller than what had been suggested previously. This, again, emphasizes the need to make comparisons within the same individuals, using appropriate methods with sufficient numbers of participants.

  18. School Start Times for Middle School and High School Students - United States, 2011-12 School Year.

    Science.gov (United States)

    Wheaton, Anne G; Ferro, Gabrielle A; Croft, Janet B

    2015-08-07

    Adolescents who do not get enough sleep are more likely to be overweight; not engage in daily physical activity; suffer from depressive symptoms; engage in unhealthy risk behaviors such as drinking, smoking tobacco, and using illicit drugs; and perform poorly in school. However, insufficient sleep is common among high school students, with less than one third of U.S. high school students sleeping at least 8 hours on school nights. In a policy statement published in 2014, the American Academy of Pediatrics (AAP) urged middle and high schools to modify start times as a means to enable students to get adequate sleep and improve their health, safety, academic performance, and quality of life. AAP recommended that "middle and high schools should aim for a starting time of no earlier than 8:30 a.m.". To assess state-specific distributions of public middle and high school start times and establish a pre-recommendation baseline, CDC and the U.S. Department of Education analyzed data from the 2011-12 Schools and Staffing Survey (SASS). Among an estimated 39,700 public middle, high, and combined schools* in the United States, the average start time was 8:03 a.m. Overall, only 17.7% of these public schools started school at 8:30 a.m. or later. The percentage of schools with 8:30 a.m. or later start times varied greatly by state, ranging from 0% in Hawaii, Mississippi, and Wyoming to more than three quarters of schools in Alaska (76.8%) and North Dakota (78.5%). A school system start time policy of 8:30 a.m. or later provides teenage students the opportunity to achieve the 8.5-9.5 hours of sleep recommended by AAP and the 8-10 hours recommended by the National Sleep Foundation.

  19. The Korean Medication Algorithm for Depressive Disorder: second revision.

    Science.gov (United States)

    Seok Seo, Jeong; Rim Song, Hoo; Bin Lee, Hwang; Park, Young-Min; Hong, Jeong-Wan; Kim, Won; Wang, Hee-Ryung; Lim, Eun-Sung; Jeong, Jong-Hyun; Jon, Duk-In; Joon Min, Kyung; Sup Woo, Young; Bahk, Won-Myong

    2014-01-01

    This study constitutes a revision of the guidelines for the treatment of major depressive disorder (MDD) issued by the Korean Medication Algorithm Project for Depressive Disorder (KMAP-DD) 2006. In incorporates changes in the experts׳ consensus that occurred between 2006 and 2012 as well as information regarding newly developed and recently published clinical trials. Using a 44-item questionnaire, an expert consensus was obtained on pharmacological treatment strategies for (1) non-psychotic MDD, (2) psychotic MDD, (3) dysthymia and depression subtypes, (4) continuous and maintenance treatment, and (5) special populations; consensus was also obtained regarding (6) the choice of an antidepressant (AD) in the context of safety and adverse effects, and (7) non-pharmacological biological therapies. AD monotherapy was recommended as the first-line strategy for nonpsychotic depression in adults, children and adolescents, elderly adults, and patients with postpartum depression or premenstrual dysphoric disorder. The combination of AD and atypical antipsychotics (AAP) was recommended for psychotic depression. The duration of the initial AD treatment for psychotic depression depends on the number of depressive episodes. Most experts recommended stopping the initial AD and AAP therapy after a certain period in patients with one or two depressive episodes. However, for those with three or more episodes, maintenance of the initial treatment was recommended for as long as possible. Monotherapy with various selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs) was recommended for dysthymic disorder and melancholic type MDD. The pharmacological treatment strategy of KMAP-DD 2012 is similar to that of KMAP-DD 2006; however, the preference for the first-line use of AAPs was stronger in 2012 than in 2006. Copyright © 2014 Elsevier B.V. All rights reserved.

  20. SIDS and other sleep-related infant deaths: expansion of recommendations for a safe infant sleeping environment.

    Science.gov (United States)

    Moon, Rachel Y

    2011-11-01

    Despite a major decrease in the incidence of sudden infant death syndrome (SIDS) since the American Academy of Pediatrics (AAP) released its recommendation in 1992 that infants be placed for sleep in a nonprone position, this decline has plateaued in recent years. Concurrently, other causes of sudden unexpected infant death occurring during sleep (sleep-related deaths), including suffocation, asphyxia, and entrapment, and ill-defined or unspecified causes of death have increased in incidence, particularly since the AAP published its last statement on SIDS in 2005. It has become increasingly important to address these other causes of sleep-related infant death. Many of the modifiable and nonmodifiable risk factors for SIDS and suffocation are strikingly similar. The AAP, therefore, is expanding its recommendations from being only SIDS-focused to focusing on a safe sleep environment that can reduce the risk of all sleep-related infant deaths including SIDS. The recommendations described in this report include supine positioning, use of a firm sleep surface, breastfeeding, room-sharing without bed-sharing, routine immunization, consideration of a pacifier, and avoidance of soft bedding, overheating, and exposure to tobacco smoke, alcohol, and illicit drugs. The rationale for these recommendations is discussed in detail in this technical report. The recommendations are published in the accompanying "Policy Statement--Sudden Infant Death Syndrome and Other Sleep-Related Infant Deaths: Expansion of Recommendations for a Safe Infant Sleeping Environment," which is included in this issue (www.pediatrics.org/cgi/doi/10.1542/peds.2011-2220).

  1. Pediatricians Working Part-Time Has Plateaued.

    Science.gov (United States)

    Cull, William L; Frintner, Mary Pat; O'Connor, Karen G; Olson, Lynn M

    2016-04-01

    To examine trends in pediatricians working part-time and residents seeking part-time work and to examine associated characteristics. The American Academy of Pediatrics (AAP) Periodic Survey of Fellows and the AAP Annual Survey of Graduating Residents were used to examine part-time employment. Fourteen periodic surveys were combined with an overall response rate of 57%. Part-time percentages were compared for surveys conducted from 2006-2009 and 2010-2013. The AAP Annual Surveys of Graduating Residents (combined response rate = 60%) from 2006-2009 were compared with 2010-2013 surveys for residents seeking and obtaining part-time positions following training. Multivariable logistic regression models identified characteristics associated with part-time work. Comparable percentages of pediatricians worked part-time in 2006-2009 (23%) and 2010-2013 (23%). There was similarly no statistically significant difference in residents seeking part-time work (30%-28%), and there was a slight decline in residents accepting part-time work (16%-13%, aOR .75, 95% CI .56-.96). Increases in working part-time were not found for any subgroups examined. Women consistently were more likely than men to work part-time (35% vs 9%), but they showed different patterns of part-time work across age. Women in their 40s (40%) were more likely than other women (33%) and men in their 60s (20%) were more likely than other men (5%) to work part-time. There has been a levelling off in the number of pediatricians working part-time and residents seeking part-time work. Overall, women remain more likely to work part-time, although 1 in 5 men over 60 work part-time. Copyright © 2016 Elsevier Inc. All rights reserved.

  2. Primary care providers' knowledge, practices, and perceived barriers to the treatment and prevention of childhood obesity.

    Science.gov (United States)

    Spivack, Jordan G; Swietlik, Maggie; Alessandrini, Evaline; Faith, Myles S

    2010-07-01

    This study evaluated primary care providers' (PCPs, pediatricians, and nurse practitioners) knowledge, current practices, and perceived barriers to childhood obesity prevention and treatment, with an emphasis on first-year well-child care visits. A questionnaire was distributed to 192 PCPs in the primary care network at The Children's Hospital of Philadelphia (CHOP) addressing (i) knowledge of obesity and American Academy of Pediatrics (AAP) guidelines, (ii) anticipatory guidance practices at well visits regarding nutrition and exercise, and (iii) perceived barriers to childhood obesity treatment and prevention. Eighty pediatricians and seven nurse practitioners responded, and a minority correctly identified the definition (26%) and prevalence (9%) of childhood overweight and AAP guidelines for exercise (39%) and juice consumption (44%). Most PCPs (81%) spent 11-20 min per well visit during the first 2 years, and 79% discussed diet, nutrition, and exercise for > or =3 min. Although >95% of PCPs discussed juice, fruits and vegetables, sippy cups, and finger foods during the first year, over 35% never discussed fast food, TV, or candy, and 55% never discussed exercise. Few rated current resources as adequate to treat or prevent childhood obesity. Over 90% rated the following barriers for obesity prevention and treatment as important or very important: parent is not motivated, child is not motivated, parents are overweight, families often have fast food, watch too much TV, and do not get enough exercise. In conclusion, there is much room to improve PCPs' knowledge of obesity and AAP guidelines. Although PCPs rate fast-food consumption, TV viewing, and lack of exercise as important treatment barriers, many never discussed these topics during the first year.

  3. Transmission of grapevine leafroll-associated virus 3 by the vine mealybug (Planococcus ficus).

    Science.gov (United States)

    Tsai, C-W; Chau, J; Fernandez, L; Bosco, D; Daane, K M; Almeida, R P P

    2008-10-01

    Grapevine leafroll disease is caused by grapevine leafroll-associated viruses (GLRaVs). Within this virus complex, GLRaV-3 is the predominant species in the world. Several GLRaVs have been shown to be transmitted from vine to vine by mealybugs although a detailed characterization of transmission biology is lacking. The introduction of the vine mealybug (Planococcus ficus) in California and other regions of the world may result in increasing disease incidence of established GLRaVs. We studied the characteristics of GLRaV-3 transmission by the vine mealybug. Our results indicate that the vine mealybug transmits GLRaV-3 in a semipersistent manner. First instars were more efficient vectors than adult mealybugs. GLRaV-3 transmission lacked a latent period in the vector. Virus transmission occurred with a 1-h acquisition access period (AAP) and peaked with a 24-h AAP. Mealybugs inoculated GLRaV-3 with a 1-h inoculation access period (IAP), and transmission efficiency increased with longer plant access period up to 24 h, after which transmission rate remained constant. After an AAP of 24 h, mealybugs lost GLRaV-3 and infectivity 4 days after virus acquisition. In addition, GLRaV-3 was not transovarially transmitted from infected females to their progeny as detected by reverse transcription polymerase chain reaction. In summary, we systematically analyzed transmission parameters of GLRaV-3 by the vine mealybug and showed that transmission of this virus occurs in a semipersistent manner. This research fills in important gaps in knowledge of leafroll virus transmission, which is critical for development of leafroll disease management practices.

  4. Evaluation of compliance with palivizumab recommendations in a multicenter study of young children presenting to the emergency department with bronchiolitis.

    Science.gov (United States)

    Mansbach, Jonathan; Kunz, Sarah; Acholonu, Uchechi; Clark, Sunday; Camargo, Carlos A

    2007-06-01

    Monthly palivizumab injections from November to March decrease risk of respiratory syncytial virus (RSV)-related hospitalization during RSV season in high-risk infants born less than 35 weeks of gestation. Our objective was to investigate compliance with the American Academy of Pediatrics (AAP) recommendations for palivizumab prophylaxis among children who present to the emergency department (ED) with bronchiolitis. Seventeen centers, from 9 US states, performed a prospective, observational study of ED patients less than 2 years with an attending physician diagnosis of bronchiolitis. Researchers conducted a structured interview, followed by a chart review, and a 2-week follow-up phone call. Of 825 eligible children, 624 (73%) were enrolled. According to AAP recommendations, 35 children (6%) should have received palivizumab, but only 17 (49%; 95% confidence interval, 31%-66%) did. Prophylaxis with palivizumab did not differ by US region (P > 0.50). The ED clinical presentations were similar when comparing those children that did and did not receive prophylaxis (all P > 0.27). Those receiving palivizumab were more likely to come to the ED using systemic corticosteroids (22% vs 7%; P = 0.003) and to be treated with corticosteroids in the ED (31% vs 15%; P = 0.02). The 2 groups were at similar risk of hospitalization (52% vs 39%; P = 0.11). According to parental report, only half of children presenting to the ED with bronchiolitis who met AAP criteria for palivizumab prophylaxis received this monoclonal antibody. Emergency department visits provide an untapped opportunity for staff to educate families and communicate with PCPs about RSV prophylaxis.

  5. Effects of Matrix Composition on Detection Threshold Estimates for Methyl Anthranilate and 2-Aminoacetophenone

    Science.gov (United States)

    Perry, Demetra M.; Hayes, John E.

    2016-01-01

    Conceptually, a detection threshold represents the lowest concentration at which an individual or a group of individuals can reliably perceive a given stimulus, with a commonly used operational definition of 50% performance above chance. Estimated detection thresholds (DTs), however, are often reported in the literature with little attention given to the matrix in which the stimuli were evaluated. Here, we highlight the influence of matrix effects on DTs for two odor-active compounds commonly found in Vitis Labrusca wines. Differences in orthonasal DTs for methyl anthranilate (MA) and 2-aminoacetophenone (2AAP) in water, a model wine system, and wine were demonstrated using a within-subject design and forced choice (i.e., criterion free) psychophysical methods. Six sample triads, each containing two blanks and one spiked sample, were presented to participants with the instructions to choose the “different” sample, and this was repeated in different matrices (water, model wine, and wine). The estimated DTs for both compounds were significantly lower in water versus the model wine system and wine. This finding recapitulates the strong need to carefully consider the nature of the delivery matrix when determining and comparing threshold estimates across studies. Additionally, data from prior reports have suggested DTs for MA and 2AAP may differ by two orders of magnitude in spite of their structural similarity. We failed to confirm this difference here: although 2AAP thresholds were somewhat lower than MA thresholds, differences were much smaller than what had been suggested previously. This, again, emphasizes the need to make comparisons within the same individuals, using appropriate methods with sufficient numbers of participants. PMID:28231131

  6. Pediatric hospital medicine core competencies: development and methodology.

    Science.gov (United States)

    Stucky, Erin R; Ottolini, Mary C; Maniscalco, Jennifer

    2010-01-01

    Pediatric hospital medicine is the most rapidly growing site-based pediatric specialty. There are over 2500 unique members in the three core societies in which pediatric hospitalists are members: the American Academy of Pediatrics (AAP), the Academic Pediatric Association (APA) and the Society of Hospital Medicine (SHM). Pediatric hospitalists are fulfilling both clinical and system improvement roles within varied hospital systems. Defined expectations and competencies for pediatric hospitalists are needed. In 2005, SHM's Pediatric Core Curriculum Task Force initiated the project and formed the editorial board. Over the subsequent four years, multiple pediatric hospitalists belonging to the AAP, APA, or SHM contributed to the content of and guided the development of the project. Editors and collaborators created a framework for identifying appropriate competency content areas. Content experts from both within and outside of pediatric hospital medicine participated as contributors. A number of selected national organizations and societies provided valuable feedback on chapters. The final product was validated by formal review from the AAP, APA, and SHM. The Pediatric Hospital Medicine Core Competencies were created. They include 54 chapters divided into four sections: Common Clinical Diagnoses and Conditions, Core Skills, Specialized Clinical Services, and Healthcare Systems: Supporting and Advancing Child Health. Each chapter can be used independently of the others. Chapters follow the knowledge, skills, and attitudes educational curriculum format, and have an additional section on systems organization and improvement to reflect the pediatric hospitalist's responsibility to advance systems of care. These competencies provide a foundation for the creation of pediatric hospital medicine curricula and serve to standardize and improve inpatient training practices. (c) 2010 Society of Hospital Medicine.

  7. Diagnostic practices for attention deficit hyperactivity disorder: a national survey of primary care physicians.

    Science.gov (United States)

    Chan, Eugenia; Hopkins, Marianne R; Perrin, James M; Herrerias, Carla; Homer, Charles J

    2005-01-01

    The American Academy of Pediatrics (AAP) clinical practice guideline emphasizes the appropriate diagnosis of attention deficit hyperactivity disorder (ADHD) in school-aged children. Although previous studies have shown wide variation in diagnostic practices for ADHD, few recent studies have examined nationally representative samples. To describe practice patterns of primary care physicians evaluating school-aged children for ADHD in the late 1990s and compare the patterns with subsequently published AAP guidelines. We surveyed a national sample of 2000 primary care pediatricians and family physicians. Of the 1076 returned surveys, 861 (43%) met data quality criteria and were included in the analysis. We tabulated frequencies for each item and used a chi2 test to examine relationships between survey items and physician characteristics. Primary care physicians most commonly reported conducting 1-2 new evaluations for ADHD per month, the majority spending 15-45 minutes and at least 2 office visits to confirm a diagnosis of ADHD. Although 58% of physicians used formal diagnostic criteria, only 28% reported using criteria according to the Diagnostic and Statistical Manual of Mental Disorders. Eighty-three percent reported using any teacher or school information such as report cards and rating scales. Approximately 70% used ADHD-specific rating scales, and 60% used global behavior scales. A quarter of respondents obtained laboratory tests such as hematocrit, lead, and thyroid function profile. Most physicians reported routinely assessing for coexisting conditions, ranging from 74% for tic disorders to 91% for depression and conduct disorder. Before the publication of AAP guidelines, primary care physicians' evaluation practices for school-aged children with ADHD varied widely, especially with respect to use of Diagnostic and Statistical Manual of Mental Disorders diagnostic criteria and inappropriate diagnostic tests.

  8. The acylaminoacyl peptidase from Aeropyrum pernix K1 thought to be an exopeptidase displays endopeptidase activity.

    Science.gov (United States)

    Kiss, András L; Hornung, Balázs; Rádi, Krisztina; Gengeliczki, Zsolt; Sztáray, Bálint; Juhász, Tünde; Szeltner, Zoltán; Harmat, Veronika; Polgár, László

    2007-04-27

    Mammalian acylaminoacyl peptidase, a member of the prolyl oligopeptidase family of serine peptidases, is an exopeptidase, which removes acylated amino acid residues from the N terminus of oligopeptides. We have investigated the kinetics and inhibitor binding of the orthologous acylaminoacyl peptidase from the thermophile Aeropyrum pernix K1 (ApAAP). Complex pH-rate profiles were found with charged substrates, indicating a strong electrostatic effect in the surroundings of the active site. Unexpectedly, we have found that oligopeptides can be hydrolysed beyond the N-terminal peptide bond, demonstrating that ApAAP exhibits endopeptidase activity. It was thought that the enzyme is specific for hydrophobic amino acids, in particular phenylalanine, in accord with the non-polar S1 subsite of ApAAP. However, cleavage after an Ala residue contradicted this notion and demonstrated that P1 residues of different nature may bind to the S1 subsite depending on the remaining peptide residues. The crystal structures of the complexes formed between the enzyme and product-like inhibitors identified the oxyanion-binding site unambiguously and demonstrated that the phenylalanine ring of the P1 peptide residue assumes a position different from that established in a previous study, using 4-nitrophenylphosphate. We have found that the substrate-binding site extends beyond the S2 subsite, being capable of binding peptides with a longer N terminus. The S2 subsite displays a non-polar character, which is unique among the enzymes of this family. The S3 site was identified as a hydrophobic region that does not form hydrogen bonds with the inhibitor P3 residue. The enzyme-inhibitor complexes revealed that, upon ligand-binding, the S1 subsite undergoes significant conformational changes, demonstrating the plasticity of the specificity site.

  9. Promoting the well-being of children whose parents are gay or lesbian.

    Science.gov (United States)

    2013-04-01

    To promote optimal health and well-being of all children, the American Academy of Pediatrics (AAP) supports access for all children to (1) civil marriage rights for their parents and (2) willing and capable foster and adoptive parents, regardless of the parents' sexual orientation. The AAP has always been an advocate for, and has developed policies to support, the optimal physical, mental, and social health and well-being of all infants, children, adolescents, and young adults. In so doing, the AAP has supported families in all their diversity, because the family has always been the basic social unit in which children develop the supporting and nurturing relationships with adults that they need to thrive. Children may be born to, adopted by, or cared for temporarily by married couples, nonmarried couples, single parents, grandparents, or legal guardians, and any of these may be heterosexual, gay or lesbian, or of another orientation. Children need secure and enduring relationships with committed and nurturing adults to enhance their life experiences for optimal social-emotional and cognitive development. Scientific evidence affirms that children have similar developmental and emotional needs and receive similar parenting whether they are raised by parents of the same or different genders. If a child has 2 living and capable parents who choose to create a permanent bond by way of civil marriage, it is in the best interests of their child(ren) that legal and social institutions allow and support them to do so, irrespective of their sexual orientation. If 2 parents are not available to the child, adoption or foster parenting remain acceptable options to provide a loving home for a child and should be available without regard to the sexual orientation of the parent(s).

  10. Influence of aripiprazole, risperidone, and amisulpride on sensory and sensorimotor gating in healthy 'low and high gating' humans and relation to psychometry.

    Science.gov (United States)

    Csomor, Philipp A; Preller, Katrin H; Geyer, Mark A; Studerus, Erich; Huber, Theodor; Vollenweider, Franz X

    2014-09-01

    Despite advances in the treatment of schizophrenia spectrum disorders with atypical antipsychotics (AAPs), there is still need for compounds with improved efficacy/side-effect ratios. Evidence from challenge studies suggests that the assessment of gating functions in humans and rodents with naturally low-gating levels might be a useful model to screen for novel compounds with antipsychotic properties. To further evaluate and extend this translational approach, three AAPs were examined. Compounds without antipsychotic properties served as negative control treatments. In a placebo-controlled, within-subject design, healthy males received either single doses of aripiprazole and risperidone (n=28), amisulpride and lorazepam (n=30), or modafinil and valproate (n=30), and placebo. Prepulse inhibiton (PPI) and P50 suppression were assessed. Clinically associated symptoms were evaluated using the SCL-90-R. Aripiprazole, risperidone, and amisulpride increased P50 suppression in low P50 gaters. Lorazepam, modafinil, and valproate did not influence P50 suppression in low gaters. Furthermore, low P50 gaters scored significantly higher on the SCL-90-R than high P50 gaters. Aripiprazole increased PPI in low PPI gaters, whereas modafinil and lorazepam attenuated PPI in both groups. Risperidone, amisulpride, and valproate did not influence PPI. P50 suppression in low gaters appears to be an antipsychotic-sensitive neurophysiologic marker. This conclusion is supported by the association of low P50 suppression and higher clinically associated scores. Furthermore, PPI might be sensitive for atypical mechanisms of antipsychotic medication. The translational model investigating differential effects of AAPs on gating in healthy subjects with naturally low gating can be beneficial for phase II/III development plans by providing additional information for critical decision making.

  11. Influence of Aripiprazole, Risperidone, and Amisulpride on Sensory and Sensorimotor Gating in Healthy ‘Low and High Gating' Humans and Relation to Psychometry

    Science.gov (United States)

    Csomor, Philipp A; Preller, Katrin H; Geyer, Mark A; Studerus, Erich; Huber, Theodor; Vollenweider, Franz X

    2014-01-01

    Despite advances in the treatment of schizophrenia spectrum disorders with atypical antipsychotics (AAPs), there is still need for compounds with improved efficacy/side-effect ratios. Evidence from challenge studies suggests that the assessment of gating functions in humans and rodents with naturally low-gating levels might be a useful model to screen for novel compounds with antipsychotic properties. To further evaluate and extend this translational approach, three AAPs were examined. Compounds without antipsychotic properties served as negative control treatments. In a placebo-controlled, within-subject design, healthy males received either single doses of aripiprazole and risperidone (n=28), amisulpride and lorazepam (n=30), or modafinil and valproate (n=30), and placebo. Prepulse inhibiton (PPI) and P50 suppression were assessed. Clinically associated symptoms were evaluated using the SCL-90-R. Aripiprazole, risperidone, and amisulpride increased P50 suppression in low P50 gaters. Lorazepam, modafinil, and valproate did not influence P50 suppression in low gaters. Furthermore, low P50 gaters scored significantly higher on the SCL-90-R than high P50 gaters. Aripiprazole increased PPI in low PPI gaters, whereas modafinil and lorazepam attenuated PPI in both groups. Risperidone, amisulpride, and valproate did not influence PPI. P50 suppression in low gaters appears to be an antipsychotic-sensitive neurophysiologic marker. This conclusion is supported by the association of low P50 suppression and higher clinically associated scores. Furthermore, PPI might be sensitive for atypical mechanisms of antipsychotic medication. The translational model investigating differential effects of AAPs on gating in healthy subjects with naturally low gating can be beneficial for phase II/III development plans by providing additional information for critical decision making. PMID:24801767

  12. The diagnosis and management of acute otitis media.

    Science.gov (United States)

    Lieberthal, Allan S; Carroll, Aaron E; Chonmaitree, Tasnee; Ganiats, Theodore G; Hoberman, Alejandro; Jackson, Mary Anne; Joffe, Mark D; Miller, Donald T; Rosenfeld, Richard M; Sevilla, Xavier D; Schwartz, Richard H; Thomas, Pauline A; Tunkel, David E

    2013-03-01

    This evidence-based clinical practice guideline is a revision of the 2004 acute otitis media (AOM) guideline from the American Academy of Pediatrics (AAP) and American Academy of Family Physicians. It provides recommendations to primary care clinicians for the management of children from 6 months through 12 years of age with uncomplicated AOM. In 2009, the AAP convened a committee composed of primary care physicians and experts in the fields of pediatrics, family practice, otolaryngology, epidemiology, infectious disease, emergency medicine, and guideline methodology. The subcommittee partnered with the Agency for Healthcare Research and Quality and the Southern California Evidence-Based Practice Center to develop a comprehensive review of the new literature related to AOM since the initial evidence report of 2000. The resulting evidence report and other sources of data were used to formulate the practice guideline recommendations. The focus of this practice guideline is the appropriate diagnosis and initial treatment of a child presenting with AOM. The guideline provides a specific, stringent definition of AOM. It addresses pain management, initial observation versus antibiotic treatment, appropriate choices of antibiotic agents, and preventive measures. It also addresses recurrent AOM, which was not included in the 2004 guideline. Decisions were made on the basis of a systematic grading of the quality of evidence and benefit-harm relationships. The practice guideline underwent comprehensive peer review before formal approval by the AAP. This clinical practice guideline is not intended as a sole source of guidance in the management of children with AOM. Rather, it is intended to assist primary care clinicians by providing a framework for clinical decision-making. It is not intended to replace clinical judgment or establish a protocol for all children with this condition. These recommendations may not provide the only appropriate approach to the management of this

  13. Recent and Past Musical Activity Predicts Cognitive Aging Variability: Direct Comparison with Leisure Activities

    Directory of Open Access Journals (Sweden)

    Brenda eHanna-Pladdy

    2012-07-01

    Full Text Available Studies evaluating the impact of modifiable lifestyle factors on cognition offer potential insights into sources of cognitive aging variability. Recently, we reported an association between extent of musical instrumental practice throughout the life span (greater than 10 years on preserved cognitive functioning in advanced age . These findings raise the question of whether there are training-induced brain changes in musicians that can transfer to nonmusical cognitive abilities to allow for compensation of age-related cognitive declines. However, because of the relationship between engagement in lifestyle activities and preserved cognition, it remains unclear whether these findings are specifically driven by musical training or the types of individuals likely to engage in greater activities in general. The current study examined the type of leisure activity (musical versus other as well as the timing of engagement (age of acquisition, past versus recent in predictive models of successful cognitive aging. Seventy age and education matched older musicians (> 10 years and nonmusicians (ages 59-80 were evaluated on neuropsychological tests and life-style activities (AAP. Partition analyses were conducted on significant cognitive measures to explain performance variance in musicians. Musicians scored higher on tests of phonemic fluency, verbal immediate recall, judgment of line orientation (JLO, and Letter Number Sequencing (LNS, but not the AAP. The first partition analysis revealed education best predicted JLO in musicians, followed by recent musical engagement which offset low education. In the second partition analysis, early age of musical acquisition (< 9 years predicted enhanced LNS in musicians, while analyses for AAP, verbal recall and fluency were not predictive. Recent and past musical activity, but not leisure activity, predicted variability across verbal and visuospatial domains in aging. Early musical acquisition predicted auditory

  14. The Child Witness in the Courtroom.

    Science.gov (United States)

    Pantell, Robert H

    2017-03-01

    Beginning in the 1980s, children have increasingly served as witnesses in the criminal, civil, and family courts; currently, >100 000 children appear in court each year. This statement updates the 1992 American Academy of Pediatrics (AAP) policy statement "The Child as a Witness" and the subsequent 1999 "The Child in Court: A Subject Review." It also builds on existing AAP policy on adverse life events affecting children and resources developed to understand and address childhood trauma. The purpose of this policy statement is to provide background information on some of the legal issues involving children testifying in court, including the accuracy and psychological impact of child testimony; to provide suggestions for how pediatricians can support patients who will testify in court; and to make recommendations for policy improvements to minimize the adverse psychological consequences for child witnesses. These recommendations are, for the most part, based on studies on the psychological and physiologic consequences of children witnessing and experiencing violence, as well as appearing in court, that have emerged since the previous AAP publications on the subject. The goal is to reduce the secondary traumatization of and long-term consequences for children providing testimony about violence they have experienced or witnessed. This statement primarily addresses children appearing in court as victims of physical or sexual abuse or as witnesses of violent acts; most of the scientific literature addresses these specific situations. It may apply, in certain situations, to children required to provide testimony in custody disputes, child welfare proceedings, or immigration court. It does not address children appearing in court as offenders or as part of juvenile justice proceedings. Copyright © 2017 by the American Academy of Pediatrics.

  15. Behavioral program synthesis with genetic programming

    CERN Document Server

    Krawiec, Krzysztof

    2016-01-01

    Genetic programming (GP) is a popular heuristic methodology of program synthesis with origins in evolutionary computation. In this generate-and-test approach, candidate programs are iteratively produced and evaluated. The latter involves running programs on tests, where they exhibit complex behaviors reflected in changes of variables, registers, or memory. That behavior not only ultimately determines program output, but may also reveal its `hidden qualities' and important characteristics of the considered synthesis problem. However, the conventional GP is oblivious to most of that information and usually cares only about the number of tests passed by a program. This `evaluation bottleneck' leaves search algorithm underinformed about the actual and potential qualities of candidate programs. This book proposes behavioral program synthesis, a conceptual framework that opens GP to detailed information on program behavior in order to make program synthesis more efficient. Several existing and novel mechanisms subs...

  16. NASA's educational programs

    Science.gov (United States)

    Brown, Robert W.

    1990-01-01

    The educational programs of NASA's Educational Affairs Division are examined. The problem of declining numbers of science and engineering students is reviewed. The various NASA educational programs are described, including programs at the elementary and secondary school levels, teacher education programs, and undergraduate, graduate, and university faculty programs. The coordination of aerospace education activities and future plans for increasing NASA educational programs are considered.

  17. LAHAN BASAH BUATAN SEBAGAI MEDIA PENGOLAHAN AIR LIMBAH BUDIDAYA UDANG VANAME (Litopenaeus vannamaei BERSALINITAS RENDAH (Constructed Wetland for Remediation of Brackish Wastewater from White Shrimp (Litopenaeus vannamaei Cultivation

    Directory of Open Access Journals (Sweden)

    Syafrudin Raharjo

    2015-07-01

    Full Text Available ABSTRAK Air limbah budidaya udang berjumlah relatif banyak dan mengandung bahan pencemar yang berpotensi mencemari lingkungan. Di sisi lain, air limbah tersebut dapat diolah dan diresirkulasi dalam sistem budidaya udang. Tujuan penelitian ini adalah untuk menyelidiki kemampuan sistem lahan basah buatan-aliran air permukaan (LBB-AAP yang ditanami dengan rumput vetiver (Chrysopogon zizanioides, L dalam menghilangkan pencemar (NO2-, NO3-, NH3, NH4+ dan PO43- dari air limbah budidaya udang vaname (Litopenaeus vannamaei kondisi mesohaline dan mengevaluasi kinerja sistem tersebut. Hasil penelitian menunjukkan bahwa sistem LBB-AAP mampu mengeliminasi parameter NO2-, NO3-, NH3, NH4+ dan PO43- secara signifikan. Rumput vetiver mampu tumbuh pada kondisi mesohaline dan dapat melakukan remediasi air limbah tersebut. Serapan rumput vetiver dalam sistem LBB-AAP untuk NO3-, NH4+ dan PO43-adalah 28, 63 dan 83 %. Desain konstruksi LBB-AAP tipe Hidroponik menunjukkan kinerja terbaik dalam pengendalian air limbah budidaya udang vaname dibandingkan dengan tipe emergent, kombinasi hidroponik dan emergent. ABSTRACT The amount of wastewater shrimp cultivation is relatively/too much, contains a variety of pollutants and potentially pollute the environment. In other side, The wastewater can be treated and also recirculated in shrimp cultivation systems. The purpose of research is to investigate the ability of flow water surface-constructed wetland system (FWS-CWs that planted vetiver grass (Chrysopogon zizanioides, L that removes of pollutants (NO2-, NO3-, NH3, NH4+ and PO43- from wastewater vaname shrimp cultivation (Litopenaeus vannamaei on conditions mesohaline and with the aim of evaluating the performance of the system. The results of the research indicate that FWS-CWs able to eliminate the parameters significantly of NO2-, NO3-, NH3, NH4+ and PO43-. Vetiver grass could grow on mesohaline conditions and it can perform remediation of the wastewater. Uptake of

  18. Abreviaturas

    OpenAIRE

    2014-01-01

    aa. vv. Autores Varios aaa American Arbitration Asociation aap Auto de la Audiencia Provincial adr Alternative Dispute Resolution AP Audiencia Provincial atsj Auto del Tribunal Superior de Justicia B. D. Base de datos boe Boletín Oficial del Estado CC Código Civil cci Cámara de Comercio Internacional CCo Código de Comercio CE Constitución Española cgp Código General del Proceso ciadi Centro Internacional de Arreglo de diferencias relativas a inversiones cnudmi Comisión de Naciones Unidas para...

  19. [Attachment in very low birthweight infants (< 1500 g) and their mothers].

    Science.gov (United States)

    Schiltz, Paul; Walger, Petra; Krischer, Maya; von Gontard, Alexander; Wendrich, Daniela; Kribs, Angela; Roth, Bernhard; Lehmkuhl, Gerd

    2013-01-01

    A long hospital stay, along with the worries about the survival and the possible disabilities the child might suffer from, mark the start into life of very low birth weight premature infants (VLBW). The goal of this trial was to study the stability of the attachment representations of very low birthweight infants (birthweight Bindung (GEV-B) and for the mothers the Adult Attachment Projective (AAP) to determine the attachment representation. The attachment representations first corresponded to a normal distribution pattern and shifted over time to a more insecure attachment. We could not determine a significant link between the attachment patterns of the child and their mother.

  20. NCBI nr-aa BLAST: CBRC-TTRU-01-1305 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-TTRU-01-1305 ref|NP_858288.2| Spa29, component of the Mxi-Spa secretion machine...64.1| ORF24 [Shigella sonnei] gb|AAP79018.1| Spa29 [Shigella flexneri] gb|AAL72306.2| Spa29, component of the Mxi-Spa secretion machi...nery [Shigella flexneri 2a str. 301] gb|AAZ91136.1| Spa29 [Shigella sonnei Ss046] gb|ABB64705.1| Spa29 [Shigella dysenteriae Sd197] NP_858288.2 0.034 28% ...

  1. NCBI nr-aa BLAST: CBRC-MEUG-01-1882 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MEUG-01-1882 ref|XP_001136482.1| PREDICTED: minichromosome maintenance protein... 2 isoform 2 [Pan troglodytes] ref|XP_001136572.1| PREDICTED: minichromosome maintenance protein 2 isoform 3... [Pan troglodytes] gb|AAP88736.1| MCM2 minichromosome maintenance deficient 2, mitotin (S. cerevisiae) [Homo... sapiens] gb|AAX42290.1| MCM2 minichromosome maintenance deficient 2 [synthetic c...onstruct] gb|AAX42291.1| MCM2 minichromosome maintenance deficient 2 [synthetic construct] XP_001136482.1 0.0 95% ...

  2. 40 CFR 419.42 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

    Science.gov (United States)

    2010-07-01

    ... 360.0 187.0 Oil and grease 16.2 8.5 Phenolic compounds 0.38 0.184 Ammonia as N 23.4 10.6 Sulfide 0.33...) BOD5 48. 26. TSS 33. 21. COD 1 360. 180. Oil and grease 15. 8. Phenolic compounds (4AAP) 0.35 0.17... gallons of flow) BOD5 0.40 0.22 TSS 0.28 0.18 COD 1 3.0 1.5 Oil and grease 0.13 0.067 Phenolic compounds...

  3. 40 CFR 419.22 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

    Science.gov (United States)

    2010-07-01

    ... COD1 210.0 109 Oil and grease 8.4 4.5 Phenolic compounds 0.21 0.10 Ammonia as N 18.8 8.5 Sulfide 0.18 0...,000 bbl feedstock) BOD5 9.9 5.5 TSS 6.9 4.4 COD1 74.0 38.4 Oil and grease 3.0 1.6 Phenolic compounds 0... Phenolic compounds (4AAP) 0.0029 0.0014 Total chromium 0.0060 0.0035 Hexavalent chromium 0.00052 0.00023 pH...

  4. 40 CFR 419.12 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

    Science.gov (United States)

    2010-07-01

    ... 10.1 COD 1 117.0 60.3 Oil and grease 6.9 3.7 Phenolic compounds 0.168 0.076 Ammonia as N 2.81 1.27... Phenolic compounds 0.060 0.027 Ammonia as N 0.99 0.45 Sulfide 0.053 0.024 Total chromium 0.122 0.071.... 8. Phenolic compounds (4AAP) 0.35 0.17 Total chromium 0.73 0.43 Hexavalent chromium 0.062 0.028 pH...

  5. 40 CFR 419.52 - Effluent limitations guidelines representing the degree of effluent reduction attainable by the...

    Science.gov (United States)

    2010-07-01

    ... 23.7 COD 1 388.0 198.0 Oil and grease 17.1 9.1 Phenolic compounds 0.40 0.192 Ammonia as N 23.4 10.6... Phenolic compounds 0.14 0.068 Ammonia as N 8.3 3.8 Sulfide 0.124 0.056 Total chromium 0.29 0.17 Hexavalent.... 8. Phenolic compounds (4AAP) 0.35 0.17 Total chromium 0.73 0.43 Hexavalent chromium 0.062 0.028 pH...

  6. Novedades en alimentación complementaria Novelties in complementary feeding

    OpenAIRE

    J.M. Marugán de Miguelsanz

    2010-01-01

    La alimentación complementaria o beikost, son los términos clásicamente utilizados para referirnos a todos los alimentos, que no sean la leche humana ni la procedente de fórmula adaptada, utilizados en la alimentación del lactante, y esenciales.
    Desde el establecimiento de las recomendaciones históricas sobre alimentación complementaria realizadas por la Academia Americana de Pediatría (AAP) y seguidamente por la Sociedad Europea de Gastroenterología, Hepatología y Nutrición Pediá...

  7. NCBI nr-aa BLAST: CBRC-MMUR-01-0860 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MMUR-01-0860 ref|NP_005963.3| pancreatic polypeptide receptor 1 [Homo sapiens]...polypeptide receptor 1; Short=PP1 gb|AAC50280.1| neuropeptide Y4 receptor protein [Homo sapiens] emb|CAA91433.1| pancreatic... polypeptide receptor PP1 [Homo sapiens] gb|AAP23199.1| pancreatic... polypeptide receptor 1 [Homo sapiens] emb|CAI13318.1| pancreatic polypeptide receptor 1 [Homo sapiens] gb|AAV68197.1| pancreatic... polypeptide receptor 1 [Homo sapiens] dbj|BAG74162.1| pancreatic polypeptide receptor 1 [synthetic construct] NP_005963.3 1e-178 83% ...

  8. NCBI nr-aa BLAST: CBRC-TSYR-01-0633 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-TSYR-01-0633 ref|NP_005963.3| pancreatic polypeptide receptor 1 [Homo sapiens]...polypeptide receptor 1; Short=PP1 gb|AAC50280.1| neuropeptide Y4 receptor protein [Homo sapiens] emb|CAA91433.1| pancreatic... polypeptide receptor PP1 [Homo sapiens] gb|AAP23199.1| pancreatic... polypeptide receptor 1 [Homo sapiens] emb|CAI13318.1| pancreatic polypeptide receptor 1 [Homo sapiens] gb|AAV68197.1| pancreatic... polypeptide receptor 1 [Homo sapiens] dbj|BAG74162.1| pancreatic polypeptide receptor 1 [synthetic construct] NP_005963.3 0.0 86% ...

  9. NCBI nr-aa BLAST: CBRC-STRI-01-2780 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-STRI-01-2780 ref|NP_005963.3| pancreatic polypeptide receptor 1 [Homo sapiens]...polypeptide receptor 1; Short=PP1 gb|AAC50280.1| neuropeptide Y4 receptor protein [Homo sapiens] emb|CAA91433.1| pancreatic... polypeptide receptor PP1 [Homo sapiens] gb|AAP23199.1| pancreatic... polypeptide receptor 1 [Homo sapiens] emb|CAI13318.1| pancreatic polypeptide receptor 1 [Homo sapiens] gb|AAV68197.1| pancreatic... polypeptide receptor 1 [Homo sapiens] dbj|BAG74162.1| pancreatic polypeptide receptor 1 [synthetic construct] NP_005963.3 6e-78 81% ...

  10. NCBI nr-aa BLAST: CBRC-TTRU-01-0673 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-TTRU-01-0673 ref|NP_005963.3| pancreatic polypeptide receptor 1 [Homo sapiens]...polypeptide receptor 1; Short=PP1 gb|AAC50280.1| neuropeptide Y4 receptor protein [Homo sapiens] emb|CAA91433.1| pancreatic... polypeptide receptor PP1 [Homo sapiens] gb|AAP23199.1| pancreatic... polypeptide receptor 1 [Homo sapiens] emb|CAI13318.1| pancreatic polypeptide receptor 1 [Homo sapiens] gb|AAV68197.1| pancreatic... polypeptide receptor 1 [Homo sapiens] dbj|BAG74162.1| pancreatic polypeptide receptor 1 [synthetic construct] NP_005963.3 0.0 87% ...

  11. NCBI nr-aa BLAST: CBRC-VPAC-01-0614 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-VPAC-01-0614 ref|NP_005963.3| pancreatic polypeptide receptor 1 [Homo sapiens]...polypeptide receptor 1; Short=PP1 gb|AAC50280.1| neuropeptide Y4 receptor protein [Homo sapiens] emb|CAA91433.1| pancreatic... polypeptide receptor PP1 [Homo sapiens] gb|AAP23199.1| pancreatic... polypeptide receptor 1 [Homo sapiens] emb|CAI13318.1| pancreatic polypeptide receptor 1 [Homo sapiens] gb|AAV68197.1| pancreatic... polypeptide receptor 1 [Homo sapiens] dbj|BAG74162.1| pancreatic polypeptide receptor 1 [synthetic construct] NP_005963.3 1e-88 85% ...

  12. NCBI nr-aa BLAST: CBRC-GGOR-01-0886 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-GGOR-01-0886 ref|NP_005963.3| pancreatic polypeptide receptor 1 [Homo sapiens]...polypeptide receptor 1; Short=PP1 gb|AAC50280.1| neuropeptide Y4 receptor protein [Homo sapiens] emb|CAA91433.1| pancreatic... polypeptide receptor PP1 [Homo sapiens] gb|AAP23199.1| pancreatic... polypeptide receptor 1 [Homo sapiens] emb|CAI13318.1| pancreatic polypeptide receptor 1 [Homo sapiens] gb|AAV68197.1| pancreatic... polypeptide receptor 1 [Homo sapiens] dbj|BAG74162.1| pancreatic polypeptide receptor 1 [synthetic construct] NP_005963.3 0.0 98% ...

  13. NCBI nr-aa BLAST: CBRC-CBRI-03-0039 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-CBRI-03-0039 ref|NP_498570.1| Serpentine Receptor, class B (beta) family membe...r (srb-9) [Caenorhabditis elegans] ref|NP_498569.2| Serpentine Receptor, class B (beta) family member (srb-8...) [Caenorhabditis elegans] sp|P83260|SRB8_CAEEL Serpentine receptor class beta-8/9 (Protein srb-8/Srb-9) gb|AAC48304.2| Serpent...ine receptor, class b (beta) protein 9 [Caenorhabditis elegans] gb|AAP68944.1| Serpent

  14. NCBI nr-aa BLAST: CBRC-CELE-03-0024 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-CELE-03-0024 ref|NP_498570.1| Serpentine Receptor, class B (beta) family membe...r (srb-9) [Caenorhabditis elegans] ref|NP_498569.2| Serpentine Receptor, class B (beta) family member (srb-8...) [Caenorhabditis elegans] sp|P83260|SRB8_CAEEL Serpentine receptor class beta-8/9 (Protein srb-8/Srb-9) gb|AAC48304.2| Serpent...ine receptor, class b (beta) protein 9 [Caenorhabditis elegans] gb|AAP68944.1| Serpent

  15. NCBI nr-aa BLAST: CBRC-CFAM-03-0005 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available gulation factor II (thrombin) receptor [Homo sapiens] gb|AAX32147.1| coagulation fa...ctor II receptor [synthetic construct] gb|ABM86025.1| coagulation factor II (thrombin) receptor [synthetic c...onstruct] gb|ABW03766.1| coagulation factor II (thrombin) receptor [synthetic construct] AAH02464.1 0.0 83% ... ...CBRC-CFAM-03-0005 gb|AAH02464.1| Coagulation factor II (thrombin) receptor [Homo sapiens] gb|AAP35943.1| coa

  16. NCBI nr-aa BLAST: CBRC-MMUR-01-1599 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available gulation factor II (thrombin) receptor [Homo sapiens] gb|AAX32147.1| coagulation fa...ctor II receptor [synthetic construct] gb|ABM86025.1| coagulation factor II (thrombin) receptor [synthetic c...onstruct] gb|ABW03766.1| coagulation factor II (thrombin) receptor [synthetic construct] AAH02464.1 0.0 89% ... ...CBRC-MMUR-01-1599 gb|AAH02464.1| Coagulation factor II (thrombin) receptor [Homo sapiens] gb|AAP35943.1| coa

  17. NCBI nr-aa BLAST: CBRC-PHAM-01-0359 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available gulation factor II (thrombin) receptor [Homo sapiens] gb|AAX32147.1| coagulation fa...ctor II receptor [synthetic construct] gb|ABM86025.1| coagulation factor II (thrombin) receptor [synthetic c...onstruct] gb|ABW03766.1| coagulation factor II (thrombin) receptor [synthetic construct] AAH02464.1 0.0 96% ... ...CBRC-PHAM-01-0359 gb|AAH02464.1| Coagulation factor II (thrombin) receptor [Homo sapiens] gb|AAP35943.1| coa

  18. NCBI nr-aa BLAST: CBRC-FCAT-01-0994 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available gulation factor II (thrombin) receptor [Homo sapiens] gb|AAX32147.1| coagulation fa...ctor II receptor [synthetic construct] gb|ABM86025.1| coagulation factor II (thrombin) receptor [synthetic c...onstruct] gb|ABW03766.1| coagulation factor II (thrombin) receptor [synthetic construct] AAH02464.1 0.0 85% ... ...CBRC-FCAT-01-0994 gb|AAH02464.1| Coagulation factor II (thrombin) receptor [Homo sapiens] gb|AAP35943.1| coa

  19. NCBI nr-aa BLAST: CBRC-XTRO-01-3803 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available gulation factor II (thrombin) receptor [Homo sapiens] gb|AAX32147.1| coagulation fa...ctor II receptor [synthetic construct] gb|ABM86025.1| coagulation factor II (thrombin) receptor [synthetic c...onstruct] gb|ABW03766.1| coagulation factor II (thrombin) receptor [synthetic construct] AAH02464.1 1e-122 52% ... ...CBRC-XTRO-01-3803 gb|AAH02464.1| Coagulation factor II (thrombin) receptor [Homo sapiens] gb|AAP35943.1| coa

  20. NCBI nr-aa BLAST: CBRC-CJAC-01-0928 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available gulation factor II (thrombin) receptor [Homo sapiens] gb|AAX32147.1| coagulation fa...ctor II receptor [synthetic construct] gb|ABM86025.1| coagulation factor II (thrombin) receptor [synthetic c...onstruct] gb|ABW03766.1| coagulation factor II (thrombin) receptor [synthetic construct] AAH02464.1 0.0 91% ... ...CBRC-CJAC-01-0928 gb|AAH02464.1| Coagulation factor II (thrombin) receptor [Homo sapiens] gb|AAP35943.1| coa

  1. NCBI nr-aa BLAST: CBRC-PCAP-01-1727 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available gulation factor II (thrombin) receptor [Homo sapiens] gb|AAX32147.1| coagulation fa...ctor II receptor [synthetic construct] gb|ABM86025.1| coagulation factor II (thrombin) receptor [synthetic c...onstruct] gb|ABW03766.1| coagulation factor II (thrombin) receptor [synthetic construct] AAH02464.1 3e-91 77% ... ...CBRC-PCAP-01-1727 gb|AAH02464.1| Coagulation factor II (thrombin) receptor [Homo sapiens] gb|AAP35943.1| coa

  2. NCBI nr-aa BLAST: CBRC-GGAL-31-0005 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available gulation factor II (thrombin) receptor [Homo sapiens] gb|AAX32147.1| coagulation fa...ctor II receptor [synthetic construct] gb|ABM86025.1| coagulation factor II (thrombin) receptor [synthetic c...onstruct] gb|ABW03766.1| coagulation factor II (thrombin) receptor [synthetic construct] AAH02464.1 1e-133 59% ... ...CBRC-GGAL-31-0005 gb|AAH02464.1| Coagulation factor II (thrombin) receptor [Homo sapiens] gb|AAP35943.1| coa

  3. NCBI nr-aa BLAST: CBRC-PTRO-06-0019 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available gulation factor II (thrombin) receptor [Homo sapiens] gb|AAX32147.1| coagulation fa...ctor II receptor [synthetic construct] gb|ABM86025.1| coagulation factor II (thrombin) receptor [synthetic c...onstruct] gb|ABW03766.1| coagulation factor II (thrombin) receptor [synthetic construct] AAH02464.1 0.0 99% ... ...CBRC-PTRO-06-0019 gb|AAH02464.1| Coagulation factor II (thrombin) receptor [Homo sapiens] gb|AAP35943.1| coa

  4. EST Table: BY916307 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available BY916307 mg0096 10/09/28 55 %/142 aa gb|AAP42818.1| NADH dehydrogenase subunit 6 [Bombyx mandarin...a] gb|ADE18271.1| NADH dehydrogenase subunit 6 [Bombyx mandarina] gb|ADE18284.1| NADH dehydrog...enase subunit 6 [Bombyx mandarina] gb|ADE18388.1| NADH dehydrogenase subunit 6 [Bombyx mandarina] gb|ADE1855...7.1| NADH dehydrogenase subunit 6 [Bombyx mandarina] gb|ADE18583.1| NADH dehydrog...enase subunit 6 [Bombyx mandarina] gb|ADE18661.1| NADH dehydrogenase subunit 6 [Bombyx mandarina] gb|ADE1871

  5. EST Table: DN985187 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available DN985187 EST01033 10/09/28 51 %/157 aa gb|AAP42818.1| NADH dehydrogenase subunit 6 [Bombyx mandarin...a] gb|ADE18271.1| NADH dehydrogenase subunit 6 [Bombyx mandarina] gb|ADE18284.1| NADH dehydr...ogenase subunit 6 [Bombyx mandarina] gb|ADE18388.1| NADH dehydrogenase subunit 6 [Bombyx mandarina] gb|ADE18...557.1| NADH dehydrogenase subunit 6 [Bombyx mandarina] gb|ADE18583.1| NADH dehydr...ogenase subunit 6 [Bombyx mandarina] gb|ADE18661.1| NADH dehydrogenase subunit 6 [Bombyx mandarina] gb|ADE18

  6. EST Table: DN237519 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available DN237519 EST00645 10/09/29 49 %/159 aa gb|AAP42818.1| NADH dehydrogenase subunit 6 [Bombyx mandarin...a] gb|ADE18271.1| NADH dehydrogenase subunit 6 [Bombyx mandarina] gb|ADE18284.1| NADH dehydr...ogenase subunit 6 [Bombyx mandarina] gb|ADE18388.1| NADH dehydrogenase subunit 6 [Bombyx mandarina] gb|ADE18...557.1| NADH dehydrogenase subunit 6 [Bombyx mandarina] gb|ADE18583.1| NADH dehydr...ogenase subunit 6 [Bombyx mandarina] gb|ADE18661.1| NADH dehydrogenase subunit 6 [Bombyx mandarina] gb|ADE18

  7. EST Table: BB983718 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available BB983718 ovS3024C07r 10/09/28 47 %/160 aa gb|AAP42818.1| NADH dehydrogenase subunit 6 [Bombyx mandarin...a] gb|ADE18271.1| NADH dehydrogenase subunit 6 [Bombyx mandarina] gb|ADE18284.1| NADH deh...ydrogenase subunit 6 [Bombyx mandarina] gb|ADE18388.1| NADH dehydrogenase subunit 6 [Bombyx mandarina] gb|AD...E18557.1| NADH dehydrogenase subunit 6 [Bombyx mandarina] gb|ADE18583.1| NADH deh...ydrogenase subunit 6 [Bombyx mandarina] gb|ADE18661.1| NADH dehydrogenase subunit 6 [Bombyx mandarina] gb|AD

  8. EST Table: BP181108 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available BP181108 ovS324C07f 10/09/28 45 %/160 aa gb|AAP42818.1| NADH dehydrogenase subunit 6 [Bombyx mandarin...a] gb|ADE18271.1| NADH dehydrogenase subunit 6 [Bombyx mandarina] gb|ADE18284.1| NADH dehy...drogenase subunit 6 [Bombyx mandarina] gb|ADE18388.1| NADH dehydrogenase subunit 6 [Bombyx mandarina] gb|ADE...18557.1| NADH dehydrogenase subunit 6 [Bombyx mandarina] gb|ADE18583.1| NADH dehy...drogenase subunit 6 [Bombyx mandarina] gb|ADE18661.1| NADH dehydrogenase subunit 6 [Bombyx mandarina] gb|ADE

  9. EST Table: BB990129 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available one) activity)|GO:0055114(oxidation reduction) 10/09/28 49 %/157 aa gb|AAP42818.1| NADH dehydrogenase subunit 6 [Bombyx mandarin...a] gb|ADE18271.1| NADH dehydrogenase subunit 6 [Bombyx mandarina] gb|ADE18284.1| NADH de...hydrogenase subunit 6 [Bombyx mandarina] gb|ADE18388.1| NADH dehydrogenase subunit 6 [Bombyx mandarin...a] gb|ADE18557.1| NADH dehydrogenase subunit 6 [Bombyx mandarina] gb|ADE18583.1| NADH de...hydrogenase subunit 6 [Bombyx mandarina] gb|ADE18661.1| NADH dehydrogenase subunit 6 [Bombyx mandarina] gb|A

  10. ORF Alignment: NC_004337 [GENIUS II[Archive

    Lifescience Database Archive (English)

    Full Text Available NC_004337 gi|56479667 >1jw2A 1 72 1 72 2e-20 ... ref|NP_706353.2| hemolysin expression modul...ating protein [Shigella flexneri 2a ... str. 301] gb|AAN42060.2| hemolysin expression ... modul...ating protein [Shigella flexneri 2a str. 301] ... ref|NP_836131.1| hemolysin expression modulati...ng ... protein [Shigella flexneri 2a str. 2457T] ... gb|AAP15937.1| hemolysin expression modul... ... protein [Escherichia coli] ref|NP_414993.1| haemolysin ... expression modulating protein [Escheri

  11. ORF Alignment: NC_002695 [GENIUS II[Archive

    Lifescience Database Archive (English)

    Full Text Available NC_002695 gi|15829767 >1jw2A 1 72 1 72 2e-20 ... ref|NP_706353.2| hemolysin expression modul...ating protein [Shigella flexneri 2a ... str. 301] gb|AAN42060.2| hemolysin expression ... modul...ating protein [Shigella flexneri 2a str. 301] ... ref|NP_836131.1| hemolysin expression modulati...ng ... protein [Shigella flexneri 2a str. 2457T] ... gb|AAP15937.1| hemolysin expression modul... ... protein [Escherichia coli] ref|NP_414993.1| haemolysin ... expression modulating protein [Escheri

  12. ORF Alignment: NC_004431 [GENIUS II[Archive

    Lifescience Database Archive (English)

    Full Text Available NC_004431 gi|26246473 >1jw2A 1 72 1 72 2e-20 ... ref|NP_706353.2| hemolysin expression modul...ating protein [Shigella flexneri 2a ... str. 301] gb|AAN42060.2| hemolysin expression ... modul...ating protein [Shigella flexneri 2a str. 301] ... ref|NP_836131.1| hemolysin expression modulati...ng ... protein [Shigella flexneri 2a str. 2457T] ... gb|AAP15937.1| hemolysin expression modul... ... protein [Escherichia coli] ref|NP_414993.1| haemolysin ... expression modulating protein [Escheri

  13. ORF Alignment: NC_004741 [GENIUS II[Archive

    Lifescience Database Archive (English)

    Full Text Available NC_004741 gi|30061960 >1jw2A 1 72 1 72 2e-20 ... ref|NP_706353.2| hemolysin expression modul...ating protein [Shigella flexneri 2a ... str. 301] gb|AAN42060.2| hemolysin expression ... modul...ating protein [Shigella flexneri 2a str. 301] ... ref|NP_836131.1| hemolysin expression modulati...ng ... protein [Shigella flexneri 2a str. 2457T] ... gb|AAP15937.1| hemolysin expression modul... ... protein [Escherichia coli] ref|NP_414993.1| haemolysin ... expression modulating protein [Escheri

  14. ORF Alignment: NC_000913 [GENIUS II[Archive

    Lifescience Database Archive (English)

    Full Text Available NC_000913 gi|16128444 >1jw2A 1 72 1 72 2e-20 ... ref|NP_706353.2| hemolysin expression modul...ating protein [Shigella flexneri 2a ... str. 301] gb|AAN42060.2| hemolysin expression ... modul...ating protein [Shigella flexneri 2a str. 301] ... ref|NP_836131.1| hemolysin expression modulati...ng ... protein [Shigella flexneri 2a str. 2457T] ... gb|AAP15937.1| hemolysin expression modul... ... protein [Escherichia coli] ref|NP_414993.1| haemolysin ... expression modulating protein [Escheri

  15. ORF Alignment: NC_002655 [GENIUS II[Archive

    Lifescience Database Archive (English)

    Full Text Available NC_002655 gi|15800189 >1jw2A 1 72 1 72 2e-20 ... ref|NP_706353.2| hemolysin expression modul...ating protein [Shigella flexneri 2a ... str. 301] gb|AAN42060.2| hemolysin expression ... modul...ating protein [Shigella flexneri 2a str. 301] ... ref|NP_836131.1| hemolysin expression modulati...ng ... protein [Shigella flexneri 2a str. 2457T] ... gb|AAP15937.1| hemolysin expression modul... ... protein [Escherichia coli] ref|NP_414993.1| haemolysin ... expression modulating protein [Escheri

  16. Application OF LIBS To Estimate The Age Of Broiler Breeders

    Science.gov (United States)

    Salam, Z. Abdel; Harith, M. A.

    2011-09-01

    Laser Induced Breakdown Spectroscopy (LIBS) is a well-known spectrochemical elemental analysis technique. In our investigations of the LIBS spectra it has been found that there is a remarkable correlation between the ionic to atomic spectral lines emission ratio and the surface hardness of eggshell for two Different Broiler Breeder at different age. The proposed technique has been applied successfully in poultry science to estimate the age of broiler breeders by measuring the surface hardness of their eggshell. The experiments have been performed on two different strains, Arbor Acres plus (AAP) and Hubard Classic (HC), and the results were satisfactory.

  17. NCBI nr-aa BLAST: CBRC-GACU-15-0006 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-GACU-15-0006 ref|NP_000943.1| platelet-activating factor receptor [Homo sapien...s] sp|P25105|PTAFR_HUMAN Platelet-activating factor receptor (PAF-R) gb|AAA60001.1| platelet activating fact...or receptor dbj|BAA01050.1| platelet-activating factor receptor [Homo sapiens] gb|AAB25755.1| platelet-activ...ating factor receptor; PAF receptor [Homo sapiens] gb|AAA60002.1| platelet activa...ting factor receptor gb|AAH13816.1| Platelet-activating factor receptor [Homo sapiens] gb|AAP32298.1| platelet

  18. NCBI nr-aa BLAST: CBRC-FRUB-02-0076 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-FRUB-02-0076 ref|NP_000943.1| platelet-activating factor receptor [Homo sapien...s] sp|P25105|PTAFR_HUMAN Platelet-activating factor receptor (PAF-R) gb|AAA60001.1| platelet activating fact...or receptor dbj|BAA01050.1| platelet-activating factor receptor [Homo sapiens] gb|AAB25755.1| platelet-activ...ating factor receptor; PAF receptor [Homo sapiens] gb|AAA60002.1| platelet activa...ting factor receptor gb|AAH13816.1| Platelet-activating factor receptor [Homo sapiens] gb|AAP32298.1| platelet

  19. NCBI nr-aa BLAST: CBRC-DNOV-01-1051 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-DNOV-01-1051 ref|NP_000943.1| platelet-activating factor receptor [Homo sapien...s] sp|P25105|PTAFR_HUMAN Platelet-activating factor receptor (PAF-R) gb|AAA60001.1| platelet activating fact...or receptor dbj|BAA01050.1| platelet-activating factor receptor [Homo sapiens] gb|AAB25755.1| platelet-activ...ating factor receptor; PAF receptor [Homo sapiens] gb|AAA60002.1| platelet activa...ting factor receptor gb|AAH13816.1| Platelet-activating factor receptor [Homo sapiens] gb|AAP32298.1| platelet

  20. NCBI nr-aa BLAST: CBRC-OCUN-01-0066 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-OCUN-01-0066 ref|NP_000943.1| platelet-activating factor receptor [Homo sapien...s] sp|P25105|PTAFR_HUMAN Platelet-activating factor receptor (PAF-R) gb|AAA60001.1| platelet activating fact...or receptor dbj|BAA01050.1| platelet-activating factor receptor [Homo sapiens] gb|AAB25755.1| platelet-activ...ating factor receptor; PAF receptor [Homo sapiens] gb|AAA60002.1| platelet activa...ting factor receptor gb|AAH13816.1| Platelet-activating factor receptor [Homo sapiens] gb|AAP32298.1| platelet

  1. NCBI nr-aa BLAST: CBRC-GGAL-23-0001 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-GGAL-23-0001 ref|NP_000943.1| platelet-activating factor receptor [Homo sapien...s] sp|P25105|PTAFR_HUMAN Platelet-activating factor receptor (PAF-R) gb|AAA60001.1| platelet activating fact...or receptor dbj|BAA01050.1| platelet-activating factor receptor [Homo sapiens] gb|AAB25755.1| platelet-activ...ating factor receptor; PAF receptor [Homo sapiens] gb|AAA60002.1| platelet activa...ting factor receptor gb|AAH13816.1| Platelet-activating factor receptor [Homo sapiens] gb|AAP32298.1| platelet

  2. NCBI nr-aa BLAST: CBRC-GACU-15-0007 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-GACU-15-0007 ref|NP_000943.1| platelet-activating factor receptor [Homo sapien...s] sp|P25105|PTAFR_HUMAN Platelet-activating factor receptor (PAF-R) gb|AAA60001.1| platelet activating fact...or receptor dbj|BAA01050.1| platelet-activating factor receptor [Homo sapiens] gb|AAB25755.1| platelet-activ...ating factor receptor; PAF receptor [Homo sapiens] gb|AAA60002.1| platelet activa...ting factor receptor gb|AAH13816.1| Platelet-activating factor receptor [Homo sapiens] gb|AAP32298.1| platelet

  3. NCBI nr-aa BLAST: CBRC-BTAU-01-3051 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-BTAU-01-3051 ref|NP_000943.1| platelet-activating factor receptor [Homo sapien...s] sp|P25105|PTAFR_HUMAN Platelet-activating factor receptor (PAF-R) gb|AAA60001.1| platelet activating fact...or receptor dbj|BAA01050.1| platelet-activating factor receptor [Homo sapiens] gb|AAB25755.1| platelet-activ...ating factor receptor; PAF receptor [Homo sapiens] gb|AAA60002.1| platelet activa...ting factor receptor gb|AAH13816.1| Platelet-activating factor receptor [Homo sapiens] gb|AAP32298.1| platelet

  4. NCBI nr-aa BLAST: CBRC-PABE-01-0131 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-PABE-01-0131 ref|NP_000943.1| platelet-activating factor receptor [Homo sapien...s] sp|P25105|PTAFR_HUMAN Platelet-activating factor receptor (PAF-R) gb|AAA60001.1| platelet activating fact...or receptor dbj|BAA01050.1| platelet-activating factor receptor [Homo sapiens] gb|AAB25755.1| platelet-activ...ating factor receptor; PAF receptor [Homo sapiens] gb|AAA60002.1| platelet activa...ting factor receptor gb|AAH13816.1| Platelet-activating factor receptor [Homo sapiens] gb|AAP32298.1| platelet

  5. NCBI nr-aa BLAST: CBRC-HSAP-01-0035 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-HSAP-01-0035 ref|NP_000943.1| platelet-activating factor receptor [Homo sapien...s] sp|P25105|PTAFR_HUMAN Platelet-activating factor receptor (PAF-R) gb|AAA60001.1| platelet activating fact...or receptor dbj|BAA01050.1| platelet-activating factor receptor [Homo sapiens] gb|AAB25755.1| platelet-activ...ating factor receptor; PAF receptor [Homo sapiens] gb|AAA60002.1| platelet activa...ting factor receptor gb|AAH13816.1| Platelet-activating factor receptor [Homo sapiens] gb|AAP32298.1| platelet

  6. NCBI nr-aa BLAST: CBRC-CFAM-02-0022 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-CFAM-02-0022 ref|NP_000943.1| platelet-activating factor receptor [Homo sapien...s] sp|P25105|PTAFR_HUMAN Platelet-activating factor receptor (PAF-R) gb|AAA60001.1| platelet activating fact...or receptor dbj|BAA01050.1| platelet-activating factor receptor [Homo sapiens] gb|AAB25755.1| platelet-activ...ating factor receptor; PAF receptor [Homo sapiens] gb|AAA60002.1| platelet activa...ting factor receptor gb|AAH13816.1| Platelet-activating factor receptor [Homo sapiens] gb|AAP32298.1| platelet

  7. NCBI nr-aa BLAST: CBRC-XTRO-01-1619 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-XTRO-01-1619 ref|NP_000943.1| platelet-activating factor receptor [Homo sapien...s] sp|P25105|PTAFR_HUMAN Platelet-activating factor receptor (PAF-R) gb|AAA60001.1| platelet activating fact...or receptor dbj|BAA01050.1| platelet-activating factor receptor [Homo sapiens] gb|AAB25755.1| platelet-activ...ating factor receptor; PAF receptor [Homo sapiens] gb|AAA60002.1| platelet activa...ting factor receptor gb|AAH13816.1| Platelet-activating factor receptor [Homo sapiens] gb|AAP32298.1| platelet

  8. NCBI nr-aa BLAST: CBRC-SARA-01-1761 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-SARA-01-1761 ref|NP_000943.1| platelet-activating factor receptor [Homo sapien...s] sp|P25105|PTAFR_HUMAN Platelet-activating factor receptor (PAF-R) gb|AAA60001.1| platelet activating fact...or receptor dbj|BAA01050.1| platelet-activating factor receptor [Homo sapiens] gb|AAB25755.1| platelet-activ...ating factor receptor; PAF receptor [Homo sapiens] gb|AAA60002.1| platelet activa...ting factor receptor gb|AAH13816.1| Platelet-activating factor receptor [Homo sapiens] gb|AAP32298.1| platelet

  9. NCBI nr-aa BLAST: CBRC-RNOR-05-0234 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-RNOR-05-0234 ref|NP_000943.1| platelet-activating factor receptor [Homo sapien...s] sp|P25105|PTAFR_HUMAN Platelet-activating factor receptor (PAF-R) gb|AAA60001.1| platelet activating fact...or receptor dbj|BAA01050.1| platelet-activating factor receptor [Homo sapiens] gb|AAB25755.1| platelet-activ...ating factor receptor; PAF receptor [Homo sapiens] gb|AAA60002.1| platelet activa...ting factor receptor gb|AAH13816.1| Platelet-activating factor receptor [Homo sapiens] gb|AAP32298.1| platelet

  10. NCBI nr-aa BLAST: CBRC-EEUR-01-0964 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-EEUR-01-0964 ref|NP_000943.1| platelet-activating factor receptor [Homo sapien...s] sp|P25105|PTAFR_HUMAN Platelet-activating factor receptor (PAF-R) gb|AAA60001.1| platelet activating fact...or receptor dbj|BAA01050.1| platelet-activating factor receptor [Homo sapiens] gb|AAB25755.1| platelet-activ...ating factor receptor; PAF receptor [Homo sapiens] gb|AAA60002.1| platelet activa...ting factor receptor gb|AAH13816.1| Platelet-activating factor receptor [Homo sapiens] gb|AAP32298.1| platelet

  11. NCBI nr-aa BLAST: CBRC-TGUT-26-0000 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-TGUT-26-0000 ref|NP_000943.1| platelet-activating factor receptor [Homo sapien...s] sp|P25105|PTAFR_HUMAN Platelet-activating factor receptor (PAF-R) gb|AAA60001.1| platelet activating fact...or receptor dbj|BAA01050.1| platelet-activating factor receptor [Homo sapiens] gb|AAB25755.1| platelet-activ...ating factor receptor; PAF receptor [Homo sapiens] gb|AAA60002.1| platelet activa...ting factor receptor gb|AAH13816.1| Platelet-activating factor receptor [Homo sapiens] gb|AAP32298.1| platelet

  12. NCBI nr-aa BLAST: CBRC-LAFR-01-0144 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-LAFR-01-0144 ref|NP_000943.1| platelet-activating factor receptor [Homo sapien...s] sp|P25105|PTAFR_HUMAN Platelet-activating factor receptor (PAF-R) gb|AAA60001.1| platelet activating fact...or receptor dbj|BAA01050.1| platelet-activating factor receptor [Homo sapiens] gb|AAB25755.1| platelet-activ...ating factor receptor; PAF receptor [Homo sapiens] gb|AAA60002.1| platelet activa...ting factor receptor gb|AAH13816.1| Platelet-activating factor receptor [Homo sapiens] gb|AAP32298.1| platelet

  13. NCBI nr-aa BLAST: CBRC-MMUS-04-0071 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-MMUS-04-0071 ref|NP_000943.1| platelet-activating factor receptor [Homo sapien...s] sp|P25105|PTAFR_HUMAN Platelet-activating factor receptor (PAF-R) gb|AAA60001.1| platelet activating fact...or receptor dbj|BAA01050.1| platelet-activating factor receptor [Homo sapiens] gb|AAB25755.1| platelet-activ...ating factor receptor; PAF receptor [Homo sapiens] gb|AAA60002.1| platelet activa...ting factor receptor gb|AAH13816.1| Platelet-activating factor receptor [Homo sapiens] gb|AAP32298.1| platelet

  14. NCBI nr-aa BLAST: CBRC-ETEL-01-1333 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-ETEL-01-1333 ref|NP_000943.1| platelet-activating factor receptor [Homo sapien...s] sp|P25105|PTAFR_HUMAN Platelet-activating factor receptor (PAF-R) gb|AAA60001.1| platelet activating fact...or receptor dbj|BAA01050.1| platelet-activating factor receptor [Homo sapiens] gb|AAB25755.1| platelet-activ...ating factor receptor; PAF receptor [Homo sapiens] gb|AAA60002.1| platelet activa...ting factor receptor gb|AAH13816.1| Platelet-activating factor receptor [Homo sapiens] gb|AAP32298.1| platelet

  15. NCBI nr-aa BLAST: CBRC-FRUB-02-0737 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-FRUB-02-0737 ref|NP_000943.1| platelet-activating factor receptor [Homo sapien...s] sp|P25105|PTAFR_HUMAN Platelet-activating factor receptor (PAF-R) gb|AAA60001.1| platelet activating fact...or receptor dbj|BAA01050.1| platelet-activating factor receptor [Homo sapiens] gb|AAB25755.1| platelet-activ...ating factor receptor; PAF receptor [Homo sapiens] gb|AAA60002.1| platelet activa...ting factor receptor gb|AAH13816.1| Platelet-activating factor receptor [Homo sapiens] gb|AAP32298.1| platelet

  16. NCBI nr-aa BLAST: CBRC-PTRO-01-0023 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-PTRO-01-0023 ref|NP_000943.1| platelet-activating factor receptor [Homo sapien...s] sp|P25105|PTAFR_HUMAN Platelet-activating factor receptor (PAF-R) gb|AAA60001.1| platelet activating fact...or receptor dbj|BAA01050.1| platelet-activating factor receptor [Homo sapiens] gb|AAB25755.1| platelet-activ...ating factor receptor; PAF receptor [Homo sapiens] gb|AAA60002.1| platelet activa...ting factor receptor gb|AAH13816.1| Platelet-activating factor receptor [Homo sapiens] gb|AAP32298.1| platelet

  17. NCBI nr-aa BLAST: CBRC-OLAT-22-0006 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-OLAT-22-0006 ref|NP_000943.1| platelet-activating factor receptor [Homo sapien...s] sp|P25105|PTAFR_HUMAN Platelet-activating factor receptor (PAF-R) gb|AAA60001.1| platelet activating fact...or receptor dbj|BAA01050.1| platelet-activating factor receptor [Homo sapiens] gb|AAB25755.1| platelet-activ...ating factor receptor; PAF receptor [Homo sapiens] gb|AAA60002.1| platelet activa...ting factor receptor gb|AAH13816.1| Platelet-activating factor receptor [Homo sapiens] gb|AAP32298.1| platelet

  18. NCBI nr-aa BLAST: CBRC-CJAC-01-1549 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-CJAC-01-1549 ref|NP_000943.1| platelet-activating factor receptor [Homo sapien...s] sp|P25105|PTAFR_HUMAN Platelet-activating factor receptor (PAF-R) gb|AAA60001.1| platelet activating fact...or receptor dbj|BAA01050.1| platelet-activating factor receptor [Homo sapiens] gb|AAB25755.1| platelet-activ...ating factor receptor; PAF receptor [Homo sapiens] gb|AAA60002.1| platelet activa...ting factor receptor gb|AAH13816.1| Platelet-activating factor receptor [Homo sapiens] gb|AAP32298.1| platelet

  19. NCBI nr-aa BLAST: CBRC-TNIG-10-0009 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-TNIG-10-0009 ref|NP_000943.1| platelet-activating factor receptor [Homo sapien...s] sp|P25105|PTAFR_HUMAN Platelet-activating factor receptor (PAF-R) gb|AAA60001.1| platelet activating fact...or receptor dbj|BAA01050.1| platelet-activating factor receptor [Homo sapiens] gb|AAB25755.1| platelet-activ...ating factor receptor; PAF receptor [Homo sapiens] gb|AAA60002.1| platelet activa...ting factor receptor gb|AAH13816.1| Platelet-activating factor receptor [Homo sapiens] gb|AAP32298.1| platelet

  20. NCBI nr-aa BLAST: CBRC-RMAC-01-0019 [SEVENS

    Lifescience Database Archive (English)

    Full Text Available CBRC-RMAC-01-0019 ref|NP_000943.1| platelet-activating factor receptor [Homo sapien...s] sp|P25105|PTAFR_HUMAN Platelet-activating factor receptor (PAF-R) gb|AAA60001.1| platelet activating fact...or receptor dbj|BAA01050.1| platelet-activating factor receptor [Homo sapiens] gb|AAB25755.1| platelet-activ...ating factor receptor; PAF receptor [Homo sapiens] gb|AAA60002.1| platelet activa...ting factor receptor gb|AAH13816.1| Platelet-activating factor receptor [Homo sapiens] gb|AAP32298.1| platelet