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Sample records for progeria research foundation

  1. Progeria Research Foundation Diagnostic Testing Program

    Science.gov (United States)

    ... scientific test to definitively diagnose children with Progeria. What is the Gene for HGPS? The gene responsible for HGPS is called LMNA (pronounced Lamin A). Within this gene there is a change in one element of DNA. This type of gene change is ...

  2. Progeria Research Foundation, Inc.

    Science.gov (United States)

    ... Find The Other 150 Kids Video Gallery In Memory Of Life According To Sam Awards & Reviews Buy & ... 2018 in Boston MA: Night of Wonder 2018: Music to your ears! Learn More College Diabetes Network ...

  3. Physical Therapy and Occupational Therapy in Progeria

    Science.gov (United States)

    Physical Therapy and Occupational Therapy in Progeria Information for Families and Caretakers from The Progeria Research Foundation Written ... accelerated aging in children. Children with Progeria need Physical Therapy (PT) and Occupational Therapy (OT) as often as ...

  4. Progeria

    Directory of Open Access Journals (Sweden)

    Kaur Charandeep

    2000-01-01

    Full Text Available A case of progeria is being reported in a 7-year old boy. He had characteristic facies, short stature, alopecia, high pitched voice, coxa valga and sclerodermatous changes in skin.

  5. Progeria

    Directory of Open Access Journals (Sweden)

    Raval Ranjan

    1992-01-01

    Full Text Available An 8-year-old boy presented with clinical manifestations of progeria. He had senile looks, scanty scalp hair, stunted growth, and wrinkled skin with loss of subcutaneous fat. Sclerodermatous changes were found on both thighs and pelvic region, which was confirmed by histopathology.

  6. Progeria

    Directory of Open Access Journals (Sweden)

    Mohamed Riyaz S

    2009-01-01

    Full Text Available Hutchinson Gilford Progeria Syndrome (HGPS is a rare, sporadic, autosomal dominant syndrome that involves premature ageing and death at early age due to myocardial infarction or stroke. A 30-year-old male with clinical and radiologic features highly suggestive of HGPS is presented here with description of differential diagnosis, dental considerations and review of literature.

  7. Progeria

    Science.gov (United States)

    ... urac.org). URAC's accreditation program is an independent audit to verify that A.D.A.M. follows ... the principles of the Health on the Net Foundation (www.hon.ch). The information provided herein should ...

  8. Mesothelioma Applied Research Foundation

    Science.gov (United States)

    Mesothelioma Foundation Experts Can Answer Your Questions! The Mesothelioma Applied Research Foundation's team of experts is available ... up for our e-newsletter . Our Impact Against Mesothelioma 9.8 Million in research funded 600 People ...

  9. Foundation for Sarcoidosis Research

    Science.gov (United States)

    ... a Clinical Trial Our mission is to stop sarcoidosis — join us. The sarcoidosis community needs your help ... receive periodic emails from the Foundation. Foundation For Sarcoidosis Research 1820 W. Webster Ave., Ste 304 Chicago, ...

  10. Intracranial Hypertension Research Foundation

    Science.gov (United States)

    ... Espanol. PARTNERSHIPS Meet our Fundraising Partners Tweet Welcome Intracranial hypertension (IH) is the general term for the neurological ... too high. (Old names for IH include Benign Intracranial Hypertension and Pseudotumor Cerebri). The Intracranial Hypertension Research Foundation ...

  11. Experimental Research of Engine Foundations

    Directory of Open Access Journals (Sweden)

    Violeta-Elena Chiţan

    2004-01-01

    Full Text Available This paper tries a compact presentation of experimental research of engine-foundations. The dynamic phenomena are so complex, that the vibrations cannot be estimated in the design stage. The design engineer of an engine foundation must foresee through a dynamic analysis of the vibrations, those measures that lead to the avoidance or limiting of the bad effects caused by the vibrations.

  12. American Foundation for AIDS Research

    Science.gov (United States)

    ... to a Cure for AIDS amfAR Institute for HIV Cure Research amfAR Research Consortium on HIV Eradication: (ARCHE) Publications ... day community update on the latest developments in HIV cure research. More New amfAR Awards Latest round of Mathilde ...

  13. Research Award: Foundations for Innovation

    International Development Research Centre (IDRC) Digital Library (Canada)

    Office 2004 Test Drive User

    IDRC is one of the world's leaders in generating new knowledge to meet global challenges. We offer a number of research awards providing a unique opportunity to enhance research skills and gain a fresh perspective on crucial development issues. These one‐year, paid, in‐house programs of training and mentorship ...

  14. Progeria: A rare genetic premature ageing disorder

    Directory of Open Access Journals (Sweden)

    Jitendra Kumar Sinha

    2014-01-01

    Full Text Available Progeria is characterized by clinical features that mimic premature ageing. Although the mutation responsible for this syndrome has been deciphered, the mechanism of its action remains elusive. Progeria research has gained momentum particularly in the last two decades because of the possibility of revealing evidences about the ageing process in normal and other pathophysiological conditions. Various experimental models, both in vivo and in vitro, have been developed in an effort to understand the cellular and molecular basis of a number of clinically heterogeneous rare genetic disorders that come under the umbrella of progeroid syndromes (PSs. As per the latest clinical trial reports, Lonafarnib, a farnesyltranferase inhibitor, is a potent ′drug of hope′ for Hutchinson-Gilford progeria syndrome (HGPS and has been successful in facilitating weight gain and improving cardiovascular and skeletal pathologies in progeroid children. This can be considered as the dawn of a new era in progeria research and thus, an apt time to review the research developments in this area highlighting the molecular aspects, experimental models, promising drugs in trial and their implications to gain a better understanding of PSs.

  15. Labor Market Progeria.

    Science.gov (United States)

    Rodeheaver, Dean

    1990-01-01

    Social ambivalence toward women's roles, sexuality, appearance, and aging combine with social standards of attractiveness to create both age and sex discrimination in the workplace. The life expectancy of presentability is shorter among women than men, thus creating an accelerated aging process termed labor market progeria. (SK)

  16. Institutional Support : Economic and Social Research Foundation ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    The Economic and Social Research Foundation (ESRF) is an independent research organization that was registered in Tanzania in October 1992. Recent uncertainty regarding the delivery ... The Science Granting Councils Initiative in sub-Saharan Africa wins Science Diplomacy Award. The Science Granting Councils ...

  17. Expert Meeting Report. Foundations Research Results

    Energy Technology Data Exchange (ETDEWEB)

    Ojczyk, C. [Univ. of Minnesota, St. Paul, MN (United States); Huelman, P. [Univ. of Minnesota, St. Paul, MN (United States); Carmody, J. [Univ. of Minnesota, St. Paul, MN (United States)

    2013-05-01

    The NorthernSTAR Building America Partnership held an expert meeting on Foundations–Research Results on November 15, 2011, in Minneapolis, MN. Audience participation was actively encouraged during each presentation to uncover needs and promote dialog among researchers and industry professionals. Key results were: greater understanding of the role of moisture transport through foundation and insulation materials and its potential impact on building durability; greater understanding of the role of foundation type in the process of selecting an insulation system for energy performance and building durability; need for research to quantify the risks associated with insulation processes to better enable users to weigh costs and benefits against the existing conditions of a home; need for improved performance modeling capabilities that address variations in foundation types and soil conditions.

  18. Research Award: Foundations for Innovation | IDRC - International ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2016-09-07

    Sep 7, 2016 ... The Foundations for Innovation program wishes to better understand the environment that enables researchers and partners to innovate, test new products and processes, and grow their adoption to improve the lives of people in low and middle income countries (LMICs). We invite applicants interested in ...

  19. Annex. Bulgarian Gender Research Foundation (BGRF)

    OpenAIRE

    2016-01-01

    The Bulgarian Gender Research Foundation was founded in June 1998 in Sofia by women committed to work in the field of women’s rights and all of them with previous experience in advocacy, education, monitoring violations of human rights, lobbying for legislative changes, preparing publications, networking. The group consists of lawyers, university professors and women’s rights activists. The group was formed because all the founders strongly felt that there was a need for specific research, ed...

  20. Hutchinson-Gilford progeria syndrome

    Directory of Open Access Journals (Sweden)

    Agarwal Uma

    2010-01-01

    Full Text Available Progeria is a rare genetic disorder characterized by premature aging, involving the skin, bones, heart, and blood vessels. We report a 4-year-old boy who presented with clinical manifestations of progeria. He had characteristic facies, prominent eyes, scalp and leg veins, senile look, loss of scalp hair, eyebrows and eyelashes, stunted growth, and sclerodermatous changes. The present case is reported due to its rarity.

  1. Progeria syndrome: A case report

    Directory of Open Access Journals (Sweden)

    Rastogi Rajul

    2008-01-01

    Full Text Available Progeria is a rare and peculiar combination of dwarfism and premature aging. The incidence is one in several million births. It occurs sporadically and is probably an autosomal recessive syndrome. Though the clinical presentation is usually typical, conventional radiological and biochemical investigations help in confirming the diagnosis. We present a rare case of progeria with most of the radiological features as a pictorial essay.

  2. Foundations of Intervention Research in Instrumental Practice

    Science.gov (United States)

    Hatfield, Johannes L.; Lemyre, Pierre-Nicolas

    2016-01-01

    The goals of the present study are to evaluate, implement, and adapt psychological skills used in the realm of sports into music performance. This research project also aims to build foundations on how to implement future interventions to guide music students on how to optimize practice toward performance. A 2-month psychological skills intervention was provided to two students from the national music academy's bachelor program in music performance to better understand how to adapt and construct psychological skills training programs for performing music students. The program evaluated multiple intervention tools including the use of questionnaires, performance profiling, iPads, electronic practice logs, recording the perceived value of individual and combined work, as well as the effectiveness of different communication forms. Perceived effects of the intervention were collected through semi-structured interviews, observations, and logs. PMID:26834660

  3. Foundations of intervention research in instrumental practice

    Directory of Open Access Journals (Sweden)

    Johannes Lunde Hatfield

    2016-01-01

    Full Text Available The goals of the present study are to evaluate, implement, and adapt psychological skills used in the realm of sports into music performance. This research project also aims to build foundations on how to implement future interventions to guide music students on how to optimize practice toward performance. A two-month psychological skills intervention was provided to two students from the national music academy’s bachelor program in music performance to better understand how to adapt and construct psychological skills training programs for performing music students. The program evaluated multiple intervention tools including the use of questionnaires, performance profiling, iPads, electronic practice logs, recording the perceived value of individual and combined work, as well as the effectiveness of different communication forms. Perceived effects of the intervention were collected through semi-structured interviews, observations, and logs.

  4. Research on simulation of soft foundation treatment

    Science.gov (United States)

    Li, Bin; Zhao, Yan

    2017-06-01

    Engineering field is in a closed area, big surcharge ratio of precipitation preloading method is the first time be proposed to apply to soft foundation treatment, and successfully applied in the artificial island foundation treatment, its advantages of efficient and fast were fully played in practice. This paper discusses process of the overload preloading method to apply to soft foundation treatment, include all key technologies of designing, monitoring and evaluated the reinforcement effect. this project can provide reference for future similar engineering construction or modification of the value of limited of specification.

  5. The research and application of anchor foundation

    Directory of Open Access Journals (Sweden)

    Li Yongping

    2016-01-01

    Full Text Available The previous project in mountain area is often used in the ordinary rock digging foundation, the foundation of the general requirements of artificial digging, when the rock very good integrity and weathering degree is low, the time-consuming, low construction efficiency, low degree of mechanization. In order to change this situation, The study of rock bolt foundation specially set up, and the application in the engineering and the follow-up project, make it become the basic types of practical value in engineering.

  6. Stem cell aging in adult progeria

    Directory of Open Access Journals (Sweden)

    Hoi-Hung Cheung

    2015-01-01

    Full Text Available Aging is considered an irreversible biological process and also a major risk factor for a spectrum of geriatric diseases. Advanced age-related decline in physiological functions, such as neurodegeneration, development of cardiovascular disease, endocrine and metabolic dysfunction, and neoplastic transformation, has become the focus in aging research. Natural aging is not regarded as a programmed process. However, accelerated aging due to inherited genetic defects in patients of progeria is programmed and resembles many aspects of natural aging. Among several premature aging syndromes, Werner syndrome (WS and Hutchinson–Gilford progeria syndrome (HGPS are two broadly investigated diseases. In this review, we discuss how stem cell aging in WS helps us understand the biology of aging. We also discuss briefly how the altered epigenetic landscape in aged cells can be reversed to a “juvenile” state. Lastly, we explore the potential application of the latest genomic editing technique for stem cell-based therapy and regenerative medicine in the context of aging.

  7. Expert Meeting Report: Foundations Research Results

    Energy Technology Data Exchange (ETDEWEB)

    Ojczyk, C.; Huelman, P.; Carmody, J.

    2013-05-01

    In the Expert Meeting Plan, the NorthernSTAR Team proposed to host two Expert Meetings in calendar year 2011. Invitees to the meetings would include experts in the current field of study, other BA team members, and representatives from DOE and NREL. They will invite leading industry experts to present at these meetings. The Expert Meetings will focus on key systems areas that will be required to meet the Building America performance goals and shall be sufficiently narrow in scope that specific conclusions, action items, and delegation of future tasks can be identified and completed. The two expert meeting topics are 'Foundations' and 'Window Retrofit.' The first session is designed as a webinar only and the second will be a live meeting.

  8. Qualitative Research in Counseling Psychology: Conceptual Foundations

    Science.gov (United States)

    Morrow, Susan L.

    2007-01-01

    Beginning with calls for methodological diversity in counseling psychology, this article addresses the history and current state of qualitative research in counseling psychology. It identifies the historical and disciplinary origins as well as basic assumptions and underpinnings of qualitative research in general, as well as within counseling…

  9. Research award: Foundations for Innovation | IDRC - International ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2017-09-06

    Sep 6, 2017 ... Deadline: September 6, 2017 Please note that all applications must be submitted online. IDRC is one of the world's leaders in generating new knowledge to meet global challenges. We offer a number of research awards providing a unique opportunity to enhance research skills and gain a fresh ...

  10. MS Swaminathan Research Foundation : Organizational and ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Building on the results of the assessment, this grant will provide core support to MSSRF's Coastal systems research and strategic planning, and promote synergies across programs through internal ... Five world-class research teams are working to develop vaccines for neglected livestock diseases in the Global South.

  11. Progeria: a new kind of Laminopathy-- report of the First European Symposium on Progeria and creation of EURO-Progeria, a European Consortium on Progeria and related disorders

    NARCIS (Netherlands)

    Brune, Thomas; Bonne, Gisele; Denecke, Jonas; Elcioglu, Nursel; Hennekam, Raoul C. M.; Marquardt, Thorsten; Ozgen, Heval; Stamsnijder, Marjet; Steichen, Elisabeth; Steinmann, Beat; Wehnert, Manfred; Levy, Nicolas

    2004-01-01

    Progeria is a rare, genetically determined condition characterized by accelerated aging in children. Its name is derived from Greek (Geron) and means "prematurely old". The classic type is the Hutchinson-Gilford Progeria Syndrome (HGPS), which was first described in England in 1886 by Dr. Jonathan

  12. Ontological and Epistemological Foundations of Qualitative Research

    Directory of Open Access Journals (Sweden)

    Irene Vasilachis de Gialdino

    2009-05-01

    Full Text Available The purpose of this paper is to describe the most relevant features of qualitative research in order to show how, from the Epistemology of the Known Subject perspective I propose, it is necessary to review first the ontological and then the epistemological grounds of this type of inquiry. I begin by following the path that leads from the Epistemology of the Knowing Subject to the Epistemology of the Known Subject, proposed as a new and non exclusive way of knowing. I pass on to describe the primary and secondary characteristics of qualitative research, expressing the need for an ontological rupture. Finally, cognitive interaction and cooperative knowledge construction are considered as two fundamental features in the process of qualitative research grounded on the Epistemology of the Known Subject. URN: urn:nbn:de:0114-fqs0902307

  13. Conceptual foundations of qualitative life course research

    Directory of Open Access Journals (Sweden)

    Walter R. Heinz

    2016-06-01

    Full Text Available Analyzing biographies is a main field of qualitative social research that studies individuals’ sensemaking in regard to transitions and life projects. The paper presents concepts for linking the macrosocial and micro-social levels in life course analysis. First, the concept of “status passage” is reviewed, with a focus on social structure, institutions, and biography. Second, the concept of “selfsocialization” is introduced, highlighting the notion of the “biographical actor”. Third, recent elaborations of the concept of “agency” in life course research are discussed. Fourth, two examples of qualitative longitudinal research are presented: one on occupational careers, another on the process of family formation. Finally, methodological implications are sketched.

  14. Foundational principles of classical Ayurveda research

    Directory of Open Access Journals (Sweden)

    Somik Raha

    2013-01-01

    Full Text Available Double-blind randomized controlled trials (RCTs are viewed as the golden standard of drug research in Western medicine. However, RCTs are far from "golden" in many respects. They are impractical for many therapies, such as for surgeries and complex lifestyle changes. They encourage a one-size-fits-all approach to medical treatment that fails to address the huge diversity among individual patients in terms of their physical and emotional symptoms, social and cultural upbringing, and other factors. Perhaps, more importantly, they do not help doctors make the best medical decisions required to produce optimal patient outcomes. To guide a search for an alternate model of medical research, three principles based on Ayurveda, an ancient and powerful system of health care that has stood the test of time, are presented. These principles, arrived at after mining Ayurvedic epistemology, are: Inductive learning, whole systems thinking, and individually optimized therapy. In honor of the ancient sages or "Rishis," whose voice is used to deliver Ayurvedic knowledge in the ancient texts of Ayurveda, these are referred to as the "Rishi principles." Individually optimized therapy is interpreted using the lens of decision analysis. Common research methodologies are examined for embodiment of these principles.

  15. Hutchinson-Gilford progeria syndrome

    Directory of Open Access Journals (Sweden)

    Zahoor Hussain Daraz

    2017-06-01

    Full Text Available Hutchinson-Gilford progeria syndrome (HGPS is a rare genetic disease in which symptoms of aging are manifested at an early age. In the present report, we describe a 9 months old female child presented with a history of progressive coarsening of skin, failure to thrive and irregular bumps over thighs, buttocks and lower limbs for the last 7½ months. In the course of time, she developed alopecia, hyperpigmented spots over the abdomen with thickening and a typical facial profile of HGPS including micrognathia, absent ear lobules, prominent eyes, loss of eyelashes, eyebrows and a bluish hue over the nose.

  16. Report on the second Intracranial Hypertension Research Foundation conference

    Science.gov (United States)

    Tanne, Emanuel

    2008-01-01

    This report highlights a conference designed for patient education on elevated cerebrospinal fluid (CSF) pressure. The conference centered on chronic intracranial hypertension (IH) including the latest research and clinical information. It was sponsored by the Intracranial Hypertension Research Foundation and held at the University of Texas Medical School, Houston, on June 21–22nd, 2008. PMID:18700981

  17. Report on the second Intracranial Hypertension Research Foundation conference

    Directory of Open Access Journals (Sweden)

    Tanne Emanuel

    2008-08-01

    Full Text Available Abstract This report highlights a conference designed for patient education on elevated cerebrospinal fluid (CSF pressure. The conference centered on chronic intracranial hypertension (IH including the latest research and clinical information. It was sponsored by the Intracranial Hypertension Research Foundation and held at the University of Texas Medical School, Houston, on June 21–22nd, 2008.

  18. Progeria in siblings: A rare case report

    Directory of Open Access Journals (Sweden)

    R Sowmiya

    2011-01-01

    Full Text Available Progeria, also known as Hutchinson-Gilford syndrome, is an extremely rare, severe genetic condition wherein symptoms resembling aspects of aging are manifested at an early age. It is an autosomal dominant disorder. It is not seen in siblings of affected children although there are very few case reports of progeria affecting more than one child in a family. Here we are presenting two siblings, a 14-year-old male and a 13-year-old female with features of progeria, suggesting a possible autosomal recessive inheritance.

  19. Learning about Progeria

    Science.gov (United States)

    ... and Projects Grant Information NIH Common Fund NIH RePORTER Research at NHGRI An Overview Branches Clinical Research ... use of high-throughput screening technology to identify chemical compounds that might reverse nuclear membrane abnormalities of ...

  20. Expanding the Foundation: Climate Change and Opportunities for Educational Research

    Science.gov (United States)

    Henderson, Joseph; Long, David; Berger, Paul; Russell, Constance; Drewes, Andrea

    2017-01-01

    Human-caused climate change is a dominant global challenge. Unlike other disciplines and fields, there has as yet been only limited attention to climate change in educational research generally, and in educational foundations in particular. Education is key to assisting humanity in mitigating and adapting to climate change, and educational…

  1. Research into employee trust: epistemological foundations and paradigmatic boundaries

    OpenAIRE

    Siebert, Sabina; Martin, Graeme; Bozic, Branko

    2016-01-01

    This article explores the epistemological roots and paradigmatic boundaries of research into employee trust, a growing field in human resource management. Drawing on Burrell and Morgan's well-known sociological paradigms and their epistemological foundations, we identify the dominant approaches to employee trust research to examine its strengths and limitations. Our review of the literature on employee trust revealed that the majority of the most cited papers were written from a psychological...

  2. NATIONAL SCIENCE FOUNDATION. Preliminary Observations on Indirect Costs for Research

    Science.gov (United States)

    2017-05-24

    NATIONAL SCIENCE FOUNDATION Preliminary Observations on Indirect Costs for Research Statement of John Neumann, Director...on Science , Space, and Technology, House of Representatives For Release on Delivery Expected at 10:00 a.m. ET Wednesday, May 24th, 2017 GAO-17...testimony before the Subcommittee on Research and Technology and the Subcommittee on Oversight, Committee on Science , Space, and Technology, House of

  3. Genetics Home Reference: Hutchinson-Gilford progeria syndrome

    Science.gov (United States)

    ... Wilson A. Progeria of stem cells: stem cell exhaustion in Hutchinson-Gilford progeria syndrome. J Gerontol A ... should not be used as a substitute for professional medical care or advice. Users with questions about ...

  4. Hutchinson-Gilford Progeria Syndrome

    Directory of Open Access Journals (Sweden)

    Gopal G

    2014-08-01

    Full Text Available Hutchinson-Gilford Progeria syndrome (HGPS is a rare pediatric genetic syndrome associated with a characteristic aged appearance very early in life, generally leading to death in the second decade of life. Apart from premature aging, the other notable characteristics of children with HGPS include extreme short stature, prominent superficial veins, poor weight gain, alopecia, as well as various skeletal and cardiovascular pathologies associated with advanced age. The pattern of inheritance of HGPS is uncertain, though both autosomal dominant and autosomal recessive modes have been described. Recent genetic studies have demonstrated mutations in the LMNA gene in children with HGPS. In this article, we report a 16 years old girl who had the phenotypic features of HGPS and was later confirmed to have LMNA mutation by genetic analysis.

  5. Foundations

    Science.gov (United States)

    Harteveld, Casper

    A building will more likely collapse if it does not have any proper foundations. Similarly, the design philosophy of Triadic Game Design (TGD) needs to reside on solid building blocks, otherwise the concept will collapse as well. In this level I will elaborate on these building blocks. First I will explain what the general idea of TGD is. It is a design philosophy, for sure, but one which stresses that an “optimum” needs to be found in a design space constituted by three different worlds: Reality, Meaning, and Play. Additionally, these worlds need to be considered simultaneously and be treated equally. The latter requires balancing the worlds which may result in different tensions, within and between two or three of the worlds. I continue by discussing each of the worlds and showing their perspective on the field of games with a meaningful purpose. From this, we clearly see that it is feasible to think of each world and that the idea makes sense. I substantiate this further by relating the notion of player and similar approaches to this framework. This level is quite a tough pill to swallow yet essential for finishing the other levels. Do not cheat or simply skip this level, but just take a big cup of coffee or tea and start reading it.

  6. Hutchinson-Gilford progeria syndrome: a rare case report

    Directory of Open Access Journals (Sweden)

    Kalegowda Deepadarshan

    2016-04-01

    Full Text Available Progeroid syndromes are characterised by clinical features of physiological aging at an early age. Hutchinson-Gilford progeria syndrome is a type of progeroid syndrome, characterised by abnormal facies, bone abnormalities, sclerodermatous skin changes and retarded physical development. Average life expectancy of progeria patients is 13 years. Herein we are reporting a case of progeria who is 21 years old.

  7. Immortalization of Werner syndrome and progeria fibroblasts

    Energy Technology Data Exchange (ETDEWEB)

    Saito, H.; Moses, R.E. (Baylor College of Medicine, Houston, TX (USA))

    1991-02-01

    Human fibroblast cells from two different progeroid syndromes, Werner syndrome (WS) and progeria, were established as immortalized cell lines by transfection with plasmid DNA containing the SV40 early region. The lineage of each immortalized cell line was confirmed by VNTR analysis. Each of the immortalized cell lines maintained its original phenotype of slow growth. DNA repair ability of these cells was also studied by measuring sensitivity to killing by uv or the DNA-damaging drugs methyl methansulfonate, bleomycin, and cis-dichlorodiamine platinum. The results showed that both WS and progeria cells have normal sensitivity to these agents.

  8. Neonatal progeria: increased ratio of progerin to lamin A leads to progeria of the newborn

    OpenAIRE

    Reunert, Janine; Wentzell, Rüdiger; Walter, Michael; Jakubiczka, Sibylle; Zenker, Martin; Brune, Thomas; Rust, Stephan; Marquardt, Thorsten

    2012-01-01

    Hutchinson–Gilford progeria syndrome (HGPS) is an important model disease for premature ageing. Affected children appear healthy at birth, but develop the first symptoms during their first year of life. They die at an average age of 13 years, mostly because of myocardial infarction or stroke. Classical progeria is caused by the heterozygous point mutation c.1824C>T in the LMNA gene, which activates a cryptic splice site. The affected protein cannot be processed correctly to mature lamin A, bu...

  9. [Cognitive therapy: foundations, conceptual models, applications and research].

    Science.gov (United States)

    Knapp, Paulo; Beck, Aaron T

    2008-10-01

    There is growing interest in the cognitive model of psychotherapy stimulated by an extensive body of research findings demonstrating its effectiveness for a varied set of psychiatric disorders and medical conditions. This review article aims to give an overview of the historical and philosophical background to contemporary cognitive and cognitive-behavioral approaches to psychotherapy, pointing out similarities across and differences between them. A presentation of the cognitive model as designed by Aaron Beck, and some of the cognitive and behavioral techniques used in emotional disorders will be discussed. Outcome studies and meta-analyses contemplating the efficacy of cognitive and cognitive-behavioral therapies in various psychological and medical conditions will be briefly depicted. Through review of articles and textbooks, especially the works of Aaron Beck from which this review article has heavily borrowed, the origins and foundations of the cognitive-behavioral approaches to the treatment of psychiatric and medical conditions are described. Through Medline, the search of randomized controlled trials and meta-analyses has pointed out the evidence-based efficacy of this psychotherapeutic approach. Cognitive-behavioral therapies in general and Beckian cognitive therapy in particular hold a theoretical foundation and a varied set of techniques, whose evidence-based efficacy was demonstrated for the treatment of diverse mental and physical conditions.

  10. Intelligent Propulsion System Foundation Technology: Summary of Research

    Science.gov (United States)

    2008-01-01

    The purpose of this cooperative agreement was to develop a foundation of intelligent propulsion technologies for NASA and industry that will have an impact on safety, noise, emissions, and cost. These intelligent engine technologies included sensors, electronics, communications, control logic, actuators, smart materials and structures, and system studies. Furthermore, this cooperative agreement helped prepare future graduates to develop the revolutionary intelligent propulsion technologies that will be needed to ensure pre-eminence of the U.S. aerospace industry. This Propulsion 21 - Phase 11 program consisted of four primary research areas and associated work elements at Ohio universities: 1.0 Turbine Engine Prognostics, 2.0 Active Controls for Emissions and Noise Reduction, 3.0 Active Structural Controls and Performance, and 4.0 System Studies and Integration. Phase l, which was conducted during the period August 1, 2003, through September 30, 2004, has been reported separately.

  11. Space Weather Research at the National Science Foundation

    Science.gov (United States)

    Moretto, T.

    2015-12-01

    There is growing recognition that the space environment can have substantial, deleterious, impacts on society. Consequently, research enabling specification and forecasting of hazardous space effects has become of great importance and urgency. This research requires studying the entire Sun-Earth system to understand the coupling of regions all the way from the source of disturbances in the solar atmosphere to the Earth's upper atmosphere. The traditional, region-based structure of research programs in Solar and Space physics is ill suited to fully support the change in research directions that the problem of space weather dictates. On the observational side, dense, distributed networks of observations are required to capture the full large-scale dynamics of the space environment. However, the cost of implementing these is typically prohibitive, especially for measurements in space. Thus, by necessity, the implementation of such new capabilities needs to build on creative and unconventional solutions. A particularly powerful idea is the utilization of new developments in data engineering and informatics research (big data). These new technologies make it possible to build systems that can collect and process huge amounts of noisy and inaccurate data and extract from them useful information. The shift in emphasis towards system level science for geospace also necessitates the development of large-scale and multi-scale models. The development of large-scale models capable of capturing the global dynamics of the Earth's space environment requires investment in research team efforts that go beyond what can typically be funded under the traditional grants programs. This calls for effective interdisciplinary collaboration and efficient leveraging of resources both nationally and internationally. This presentation will provide an overview of current and planned initiatives, programs, and activities at the National Science Foundation pertaining to space weathe research.

  12. Self-Determination Theory as a Foundation for Personality Researchers.

    Science.gov (United States)

    Sheldon, Kennon M; Prentice, Mike

    2017-11-16

    In this introductory article we first describe the impetus for this special issue. What made us think that Self-Determination Theory (SDT) might provide a sort of foundation for the rest of personality psychology? For readers unfamiliar with SDT, we then provide a historical overview which covers the evolution of the six "mini-theories" that currently comprise SDT: cognitive evaluation theory, causality orientations theory, organismic integration theory, basic psychological needs theory, goal contents theory, and relational motivation theory. Following each section are preliminary suggestions about how each mini-theory might be useful or informative in other branches of personality. This special issue contains 9 articles, each of which makes its own attempt to newly link its area of personality research to SDT. Even if SDT is not the appropriate seed for greater consilience in personality psychology, we urge the field not to neglect the search for unifying principles (Sheldon, Chen, & Hilpert, 2011); it may finally be time to renew the search for a "grand theory" in personality. This article is protected by copyright. All rights reserved. © 2017 Wiley Periodicals, Inc.

  13. Environmental Science and Research Foundation, Inc. annual technical report: Calendar year 1997

    Energy Technology Data Exchange (ETDEWEB)

    Reynolds, R.D.; Warren, R.W. [eds.

    1998-05-01

    This Annual Technical Report describes work conducted for the Department of Energy, Idaho Operations Office (DOE-ID), by the Environmental Science and Research Foundation (Foundation). The Foundation`s mission to DOE-ID provides support in several key areas. The Foundation conducts an environmental monitoring and surveillance program over an area covering much of the upper Snake River Plain, and provides environmental education and support services related to Idaho National Engineering and Environmental Laboratory (INEEL) natural resource issues. Also, the Foundation, with its University Affiliates, conducts ecological and radioecological research on the Idaho National Environmental Research Park. This research benefits major DOE-ID programs including Waste Management, Environmental Restoration, Spent Nuclear Fuels, and Land Management Issues. Summaries are included of the individual research projects.

  14. Neonatal progeria: increased ratio of progerin to lamin A leads to progeria of the newborn.

    Science.gov (United States)

    Reunert, Janine; Wentzell, Rüdiger; Walter, Michael; Jakubiczka, Sibylle; Zenker, Martin; Brune, Thomas; Rust, Stephan; Marquardt, Thorsten

    2012-09-01

    Hutchinson-Gilford progeria syndrome (HGPS) is an important model disease for premature ageing. Affected children appear healthy at birth, but develop the first symptoms during their first year of life. They die at an average age of 13 years, mostly because of myocardial infarction or stroke. Classical progeria is caused by the heterozygous point mutation c.1824C>T in the LMNA gene, which activates a cryptic splice site. The affected protein cannot be processed correctly to mature lamin A, but is modified into a farnesylated protein truncated by 50 amino acids (progerin). Three more variations in LMNA result in the same mutant protein, but different grades of disease severity. We describe a patient with the heterozygous LMNA mutation c.1821G>A, leading to neonatal progeria with death in the first year of life. Intracellular lamin A was downregulated in the patient's fibroblasts and the ratio of progerin to lamin A was increased when compared with HGPS. It is suggestive that the ratio of farnesylated protein to mature lamin A determines the disease severity in progeria.

  15. Environmental Science and Research Foundation annual technical report: Calendar year 1996

    Energy Technology Data Exchange (ETDEWEB)

    Morris, R.C.; Blew, R.D. [eds.

    1997-07-01

    This Annual Technical Report describes work conducted for the Department of Energy, Idaho Operations Office (DOE-ID), by the Environmental Science and Research Foundation (Foundation). The Foundation`s mission to DOE-ID provides support in several key areas. The authors conduct an environmental monitoring and surveillance program over an area covering much of the upper Snake River Plain, and provide environmental education and support services related to Idaho National Engineering and Environmental Laboratory (INEEL) natural resource issues. Also, the Foundation, with its University Affiliates, conducts ecological and radioecological research in the Idaho National Environmental Research Park. This research benefits major DOE-ID programs including Waste Management, Environmental Restoration, Spent Nuclear Fuels, and Land Management Issues. The major accomplishments of the Foundation and its University Affiliates during the calendar year 1996 are discussed.

  16. The Medical Science Research and Development Supported by the Korea Science and Engineering Foundation

    National Research Council Canada - National Science Library

    Min, Tae-Sun; Han, Jin; Kim, Seong-Yong; Rhee, Byoung-Doo; Kim, Myung-Suk

    2005-01-01

    This study examined ways of promoting research in the medical sciences by evaluating trends in research funding, and the present status of research funding by the Korea Science and Engineering Foundation (KOSEF...

  17. Research on the Teaching System of the University Computer Foundation

    Directory of Open Access Journals (Sweden)

    Ji Xiaoyun

    2016-01-01

    Full Text Available Inonal students, the teaching contents, classification, hierarchical teaching methods with the combination of professional level training, as well as for top-notch students after class to promote comprehensive training methods for different students, establish online Q & A, test platform, to strengthen the integration professional education and computer education and training system of college computer basic course of study and exploration, and the popularization and application of the basic programming course, promote the cultivation of university students in the computer foundation, thinking methods and innovative practice ability, achieve the goal of individualized educ the College of computer basic course teaching, the specific circumstances of the need for students, professiation.

  18. Research Review: The Dana Foundation and ArtsConnection

    Science.gov (United States)

    Brown, Susannah

    2007-01-01

    In this Research Review, various models of research found in a recent publication from ArtsConnection, New York, are discussed. The researchers for the first study look at research from each person's unique perspective and value the descriptive and analytical process of inquiry. The researchers in the second study focus on research as a heuristic…

  19. Decreased repair of gamma damaged DNA in progeria

    Energy Technology Data Exchange (ETDEWEB)

    Rainbow, A.J.; Howes, M.

    1977-01-01

    A sensitive host-cell reactivation technique was used to examine the DNA repair ability of fibroblasts from two patients with classical progeria. Fibroblasts were infected with either non-irradiated or gamma-irradiated adenovirus type 2 and at 48 hrs after infection cells were examined for the presence of viral structural antigens using immunofluorescent staining. The production of viral structural antigens was considerably reduced in the progeria lines as compared to normal fibroblasts when gamma-irradiated virus was used, indicating a defect in the repair of gamma ray damaged DNA in the progeria cells.

  20. Lethal neonatal Hutchinson-Gilford progeria syndrome.

    Science.gov (United States)

    Rodríguez, J I; Pérez-Alonso, P; Funes, R; Pérez-Rodríguez, J

    1999-01-29

    We report on a 35-week gestation female fetus with Hutchinson-Gilford progeria (HGP). This patient, who is the first reported with neonatal HGP in the English literature but is the fourth, counting three previous French cases, supports the existence of a more severe prenatal form of progeria. She died 7 hours after birth and presented with intrauterine growth retardation, premature aging, absence of subcutaneous fat, brachydactyly, absent nipples, hypoplastic external genitalia, and abnormal ear lobes. The child's combination of clinical and skeletal manifestations differentiates this form of HGP from other progeroid syndromes with neonatal presentation. We also report previously undescribed autopsy findings including premature loss of hair follicles, premature regression of the renal nephrogenic layer, and premature closure of the growth plates in the distal phalanges that may be related to the aging processes in this condition. We could not find any histological data to support acro-osteolysis, which is the radiographic sign of brachydactyly. The terminal phalanges in HGP seem to be underdeveloped rather than osteolytic.

  1. Preparation of Educational Researchers in Philosophical Foundations of Inquiry.

    Science.gov (United States)

    Paul, James L.; Marfo, Kofi

    2001-01-01

    Discusses the nature, scope, and significance of basic philosophical issues in the preparation of researchers, focusing on two assertions: (1) that the curriculum for preparing educational researchers continues to be dominated by logical empiricism; and (2) that research education places a disproportionate emphasis on technical methods and…

  2. Research within the disciplines foundations for reference and library instruction

    CERN Document Server

    Keeran, Peggy

    2014-01-01

    Research within the Disciplines is designed to help reference librarians - and students studying to become librarians - gain that deeper understanding of disciplinary differences that allows them to comfortably solve information needs rather than merely responding to questions, and practical knowledge about how to work with researchers in a library setting.

  3. Active Transportation and Demand Management (ATDM) foundational research : Analysis, Modeling, and Simulation (AMS) capabilities assessment.

    Science.gov (United States)

    2013-06-01

    As part of the Federal Highway Administrations (FHWAs) Active Transportation and Demand Management (ATDM) Foundational Research, this publication identifies the AMS needs to support simulated real-time and real-time analysis to evaluate the imp...

  4. Environmental Science and Research Foundation. Annual technical report, April 11, 1994--December 31, 1994

    Energy Technology Data Exchange (ETDEWEB)

    Reynolds, T.D.; Morris, R.C.; Markham, O.D. [eds.

    1995-06-01

    This Annual Technical Report describes work conducted for the Department of Energy, Idaho Operations Office, by the Environmental Science and Research Foundation (Foundation) for work under contract DE-AC07-94ID13268. The Foundation began, on April 11, 1994, to conduct environmental surveillance near to and distant from the Idaho National Engineering Laboratory, provide environmental public relations and education related to INEL natural resource issues, and conduct ecological and radioecological research benefiting major DOE-ID programs including Waste Management, Environmental Restoration, Spent Nuclear Fuels, and Infrastructure.

  5. Novel LMNA mutations cause an aggressive atypical neonatal progeria without progerin accumulation

    NARCIS (Netherlands)

    Soria-Valles, Clara; Carrero, Dido; Gabau, Elisabeth; Velasco, Gloria; Quesada, Víctor; Bárcena, Clea; Moens, Marleen; Fieggen, Karen; Möhrcken, Silvia; Owens, Martina; Puente, Diana A.; Asensio, Óscar; Loeys, Bart; Pérez, Ana; Benoit, Valerie; Wuyts, Wim; Lévy, Nicolas; Hennekam, Raoul C.; de Sandre-Giovannoli, Annachiara; López-Otín, Carlos

    2016-01-01

    Background Progeroid syndromes are genetic disorders that recapitulate some phenotypes of physiological ageing. Classical progerias, such as Hutchinson-Gilford progeria syndrome (HGPS), are generally caused by mutations in LMNA leading to accumulation of the toxic protein progerin and consequently,

  6. Bibliometric analyses of publications from Centres of Excellence funded by the Danish National Research Foundation

    DEFF Research Database (Denmark)

    Schneider, Jesper Wiborg; Costas, Rodrigo; Henriksen, Dorte

    2013-01-01

    , the interaction with host institutions, and the governance and management of the DNRF. The evaluation concludes that the DNRF has had a very positive impact on the quality of research in Denmark and recommends that the foundation is re-funded. The evaluation is based on a bibliometric study, self......-assessment report by DNRF, numerous interviews and desk studies. Appendix 5: Bibliometric analyses of publications from Centres of Excellence funded by the Danish National Research Foundation...

  7. [German Research Foundation (DFG) Early Career Investigators Workshop in Health Services Research: concept - progress - feedback].

    Science.gov (United States)

    Scherer, Martin; Lühmann, Dagmar; Raspe, Heiner

    2012-01-01

    In December 2010, the Institutes for Social Medicine and Cancer Epidemiology of the University of Lübeck hosted the first Workshop for Early Career Investigators in the area of Health Services Research. This workshop was funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) with the aim to promote young scientists and researchers that wish to pursue research in the field of Health Services Research in an early phase of their career. The following report addresses the background, concept and progress of the initiative. All applicants had to submit a detailed project proposal and underwent a rigorous selection process. The projects presented at the workshop covered a wide range of topics, such as, for example, access to health care, common elements of mental illnesses and psychosomatic disorders, quality assurance in medical practices (i.e., evaluation of disease management programmes) and targets in rehabilitation. A major subject was migration as a challenge to Health Services Research. The 20 best applicants out of 121 were invited to attend the programme. During five days the participants had the opportunity to present their projects and discuss current issues as well as fundamental themes in study design. At the same time, national and international leading experts gave a series of lectures on current topics of Health Services Research. In numerous discussion groups and topical workshops participants and speakers explored and sought solutions to specific research issues. Following the programme participants are expected to finalise their research proposals and apply for funding to the DFG. To foster networking among early-career researchers, an alumni meeting is scheduled after 12 months. The DFG Workshop for Early Career Investigators was the first of its kind in the field of Health Services Research in Germany. However, evidence of its sustainability will have to be obtained from the future development of the German Health Services

  8. Laying the Foundations for Scientometric Research: A Data Science Approach

    Science.gov (United States)

    Perron, Brian E.; Victor, Bryan G.; Hodge, David R.; Salas-Wright, Christopher P.; Vaughn, Michael G.; Taylor, Robert Joseph

    2017-01-01

    Objective: Scientometric studies of social work have stagnated due to problems with the organization and structure of the disciplinary literature. This study utilized data science to produce a set of research tools to overcome these methodological challenges. Method: We constructed a comprehensive list of social work journals for a 25-year time…

  9. Disparate foundations of scientists' policy positions on contentious biomedical research.

    Science.gov (United States)

    Edelmann, Achim; Moody, James; Light, Ryan

    2017-06-13

    What drives scientists' position taking on matters where empirical answers are unavailable or contradictory? We examined the contentious debate on whether to limit experiments involving the creation of potentially pandemic pathogens. Hundreds of scientists, including Nobel laureates, have signed petitions on the debate, providing unique insights into how scientists take a public stand on important scientific policies. Using 19,257 papers published by participants, we reconstructed their collaboration networks and research specializations. Although we found significant peer associations overall, those opposing "gain-of-function" research are more sensitive to peers than are proponents. Conversely, specializing in fields directly related to gain-of-function research (immunology, virology) predicts public support better than specializing in fields related to potential pathogenic risks (such as public health) predicts opposition. These findings suggest that different social processes might drive support compared with opposition. Supporters are embedded in a tight-knit scholarly community that is likely both more familiar with and trusting of the relevant risk mitigation practices. Opponents, on the other hand, are embedded in a looser federation of widely varying academic specializations with cognate knowledge of disease and epidemics that seems to draw more heavily on peers. Understanding how scientists' social embeddedness shapes the policy actions they take is important for helping sides interpret each other's position accurately, avoiding echo-chamber effects, and protecting the role of scientific expertise in social policy.

  10. Progeria (Hutchison - Gilford syndrome in siblings: In an autosomal recessive pattern of inheritance

    Directory of Open Access Journals (Sweden)

    Raghu Tanjore

    2001-09-01

    Full Text Available Progeria is an autosomal dominant, premature aging syndrome. Six and three year old female siblings had sclcrodermatous changes over the extremities, alopecia, beaked nose, prominent veins and bird-like facies. Radiological features were consistent with features of progeria. The present case highlights rarity of progeria in siblings with a possible autosomal recessive pattern.

  11. Building a Foundation for Knowledge Management Research: Developing, Validating, and Applying the Knowledge Internalization Construct

    Science.gov (United States)

    Wipawayangkool, Kamphol

    2011-01-01

    The notion of knowledge internalization (KI), albeit a critical link in Nonaka's (1994) organizational knowledge creation theory, has not been rigorously conceptualized and defined, let alone operationalized. To strengthen the foundation for knowledge management (KM) research, we attempt to fulfill the following research objectives in the three…

  12. Connecting Creativity Research and Practice in Art Education: Foundations, Pedagogies, and Contemporary Issues

    Science.gov (United States)

    Bastos, Flávia, Ed.; Zimmerman, Enid, Ed.

    2015-01-01

    In three broad sections--Foundations, Pedagogies, and Contemporary Issues--the editors and chapter authors of "Connecting Creativity Research and Practice in Art Education" articulate the significance of reconsidering creativity as a crucial dimension of art education research and practice today. This book represents a groundbreaking…

  13. Research for assessment, not deployment, of Climate Engineering: The German Research Foundation's Priority Program SPP 1689

    Science.gov (United States)

    Oschlies, Andreas; Klepper, Gernot

    2017-01-01

    The historical developments are reviewed that have led from a bottom-up responsibility initiative of concerned scientists to the emergence of a nationwide interdisciplinary Priority Program on the assessment of Climate Engineering (CE) funded by the German Research Foundation (DFG). Given the perceived lack of comprehensive and comparative appraisals of different CE methods, the Priority Program was designed to encompass both solar radiation management (SRM) and carbon dioxide removal (CDR) ideas and to cover the atmospheric, terrestrial, and oceanic realm. First, key findings obtained by the ongoing Priority Program are summarized and reveal that, compared to earlier assessments such as the 2009 Royal Society report, more detailed investigations tend to indicate less efficiency, lower effectiveness, and often lower safety. Emerging research trends are discussed in the context of the recent Paris agreement to limit global warming to less than two degrees and the associated increasing reliance on negative emission technologies. Our results show then when deployed at scales large enough to have a significant impact on atmospheric CO2, even CDR methods such as afforestation—often perceived as "benign"—can have substantial side effects and may raise severe ethical, legal, and governance issues. We suppose that before being deployed at climatically relevant scales, any negative emission or CE method will require careful analysis of efficiency, effectiveness, and undesired side effects.

  14. Promising and Established Investigators' Experiences Participating in the National Athletic Trainers' Association Foundation Research Mentor Program.

    Science.gov (United States)

    Nottingham, Sara L; Mazerolle, Stephanie M; Barrett, Jessica L

    2017-04-01

      Mentorship is a helpful resource for individuals who transition from doctoral student to tenure-track faculty member. The National Athletic Trainers' Association (NATA) Research & Education Foundation offers a Research Mentor Program to provide mentorship to promising investigators, particularly as they work to establish independent lines of research.   To gain the perspectives of promising and established investigators on their participation in the NATA Foundation Research Mentor Program.   Qualitative, phenomenological research.   Higher education institutions.   Seven promising investigators (5 women, 2 men) and 7 established investigators (2 women, 5 men), all of whom had completed the NATA Foundation Research Mentor Program. Data Collection and Analysis We developed and piloted intervi: ew guides designed to gain participants' perspectives on their experiences participating in the NATA Foundation Research Mentor Program. Semistructured telephone interviews were completed with each individual and transcribed verbatim. Data were analyzed using a phenomenological approach, and saturation was obtained. Trustworthiness was established with the use of member checking, multiple-analyst triangulation, and data-source triangulation.   Three themes emerged from the interviews: (1) motivation, (2) collaboration, and (3) resources. Participants were motivated to become involved because they saw the value of mentorship, and mentees desired guidance in their research. Participants believed that collaboration on a project contributed to a positive relationship, and they also desired additional program and professional resources to support novice faculty.   Promising and established investigators should be encouraged to engage in mentoring relationships to facilitate mentees' research agendas and professional development. The NATA Foundation and athletic training profession may consider providing additional resources for novice faculty, such as training on

  15. The research infrastructure of Chinese foundations, a database for Chinese civil society studies.

    Science.gov (United States)

    Ma, Ji; Wang, Qun; Dong, Chao; Li, Huafang

    2017-07-25

    This paper provides technical details and user guidance on the Research Infrastructure of Chinese Foundations (RICF), a database of Chinese foundations, civil society, and social development in general. The structure of the RICF is deliberately designed and normalized according to the Three Normal Forms. The database schema consists of three major themes: foundations' basic organizational profile (i.e., basic profile, board member, supervisor, staff, and related party tables), program information (i.e., program information, major program, program relationship, and major recipient tables), and financial information (i.e., financial position, financial activities, cash flow, activity overview, and large donation tables). The RICF's data quality can be measured by four criteria: data source reputation and credibility, completeness, accuracy, and timeliness. Data records are properly versioned, allowing verification and replication for research purposes.

  16. Technology Solutions Case Study: Cold Climate Foundation Wall Hygrothermal Research Facility, Cloquet, Minnesota

    Energy Technology Data Exchange (ETDEWEB)

    None

    2014-09-01

    This case study describes the University of Minnesota’s Cloquet Residential Research Facility (CRRF) in northern Minnesota, which features more than 2,500 ft2 of below-grade space for building systems foundation hygrothermal research. Here, the NorthernSTAR Building America Partnership team researches ways to improve the energy efficiency of the building envelope, including wall assemblies, basements, roofs, insulation, and air leakage.

  17. Deconstructing the Elephant and the Flag in the Lavatory: Promises and Problems of Moral Foundations Research

    Science.gov (United States)

    Haste, Helen

    2013-01-01

    Moral Foundations research offers rich promise, opening up key questions about how affect and cognition are integrated in moral response, and exploring how different moral discourses may supply meaning and valence to moral experience. Haidt and his colleagues also associate different discourses with different political positions. However I address…

  18. Hutchinson-Gilford progeria syndrome: review of the phenotype

    NARCIS (Netherlands)

    Hennekam, Raoul C. M.

    2006-01-01

    Hutchinson-Gilford progeria syndrome (HGPS) is a rare but well known entity characterized by extreme short stature, low body weight, early loss of hair, lipodystrophy, scleroderma, decreased joint mobility, osteolysis, and facial features that resemble aged persons. Cardiovascular compromise leads

  19. INSTRUMENTS OF SUPPORT FOR RESEARCH AND DEVELOPMENT FUNDED BY LEADING DOMESTIC AND INTERNATIONAL SCIENCE FOUNDATIONS

    Directory of Open Access Journals (Sweden)

    Irina E. Ilina

    2017-06-01

    Full Text Available Introduction: one of the key aspects of the knowledge economy development is the growing significance of the results of research and development. The education and basic research play a key role in this process. Funding for education and fundamental science is carried out mainly at the expense of the state resources, including a system of foundations for scientific, engineering and innovation activities in Russia. The purpose of this article is to present recommendations for improving the tools of domestic foundations in funding fundamental research and development, including education and training. The propositions are made with a comparative analysis of the domestic and foreign science foun dations’ activities. Materials and Methods: the authors used analysis, comparison, induction, deduction, graphical analysis, generalisation and other scientific methods during the study. Results: the lack of comparability between domestic and foreign scientific funds in the volume of funding allocated for basic research and development is revealed. This situation affects the scientific research. The foreign foundations have a wide range of instruments to support research projects at all stages of the life cycle of grants for education and training prior to release of an innovative product to market (the use of “innovation elevator” system. The Russian national scientific foundations have no such possibilities. The authors guess that the Russian organisations ignore some of the instruments for supporting research and development. Use of these tools could enhance the effectiveness of research projects. According to the study of domestic and foreign experience in supporting research and development, the authors proposed a matrix composed of instruments for support in the fields of basic scientific researches and education with such phases of the project life cycle as “research” and “development”. Discussion and Conclusions: the foreign science

  20. Building a Bright Future. The Hydro Research Foundation's Fellowship Program

    Energy Technology Data Exchange (ETDEWEB)

    Vaughn, Brenna [Hydro Research Foundation, Inc., Evergreen, CO (United States); Linke, Deborah M. [Hydro Research Foundation, Inc., Evergreen, CO (United States)

    2015-12-29

    The Hydro Fellowship Program (program) began as an experiment to discover whether the hydropower industry could find mechanisms to attract new entrants through conducting relevant research to benefit the industry. This nationwide, new-to-the-world program was started through funding from the Wind and Water Power Technologies Office of the Energy Efficiency and Renewable Energy (EERE) Office of the Department of Energy (DOE). Between 2010-2015, the Hydro Research Foundation (HRF) designed and implemented a program to conduct valuable research and attract new entrants to the hydro workforce. This historic grant has empowered and engaged industry members from 25 organizations by working with 91 students and advisors at 24 universities in 19 states. The work funded answered pressing research needs in the fields of civil, mechanical, environmental, and electrical engineering, as well as law, energy engineering and materials innovation. In terms of number of individuals touched through funding, 148 individuals were supported by this work through direct research, mentorship, oversight of the work, partnerships and the day-to-day program administration. Based on the program results, it is clear that the funding achieved the hoped-for outcomes and has the capacity to draw universities into the orbit of hydropower and continue the conversation about industry research and development needs. The Foundation has fostered unique partnerships at the host universities and has continued to thrive with the support of the universities, advisors, industry and the DOE. The Foundation has demonstrated industry support through mentorships, partnerships, underwriting the costs and articulating the universities’ support through in-kind cost sharing. The Foundation recommends that future work be continued to nurture these graduate level programs using the initial work and improvements in the successor program, the Research Awards Program, while stimulating engagement of academia at the

  1. Action Research Built on Uncertain Foundations: The Internship and Action-Research in a Graduate Teaching Degree

    Science.gov (United States)

    Loughland, Tony; Bowen, Margo

    2012-01-01

    This paper analyses the uncertain foundations of the use of action research in a graduate teaching degree. This analysis is conducted by the course coordinator in partnership with a recent graduate. The uncertainty is traced to the pedagogical incoherence of the course that is caused by philosophical infidelity. The philosophy and practice of the…

  2. Engaging Girls in STEM: A Discussion of Foundational and Current Research on What Works

    Science.gov (United States)

    Sharma, M.; Peterson, K. A.; Bleacher, L. V.; Smith, D. A.

    2012-08-01

    This article summarizes a panel discussion with Jolene Jesse (Program Director, NSF Research on Gender in Science and Engineering program) and Laura Migus (Director of Equity & Diversity at the Association of Science Technology Centers) on research related to gender in science, technology, engineering and math (STEM). Moderated by Ms. Karen Peterson from the NSF-funded National Girls Collaborative Project, Dr. Jesse and Ms. Migus discussed foundational and current research on pressing questions about the lack of gender diversity in STEM advanced education and careers, and on strategies the EPO community could employ in designing and implementing programs to encourage more girls and women to engage in STEM for the long term.

  3. Corporate Foundations

    DEFF Research Database (Denmark)

    Herlin, Heidi; Thusgaard Pedersen, Janni

    2013-01-01

    This paper aims to explore the potential of Danish corporate foundations as boundary organizations facilitating relationships between their founding companies and non-governmental organizations (NGOs). Hitherto, research has been silent about the role of corporate foundations in relation to cross...... action between business and NGOs through convening, translation, collaboration, and mediation. Our study provides valuable insights into the tri-part relationship of company foundation NGO by discussing the implications of corporate foundations taking an active role in the realm of corporate social...

  4. A case of progeria syndrome treated as VIP patient

    Directory of Open Access Journals (Sweden)

    Seema Mahant, Mahant PD, C.M. Reddy

    2014-11-01

    Full Text Available Progeria is rare autosomal recessive genetic disease with an incidence of about one in eight million. He was 16 years old boy lying on the couch. He was short stature thin with minimal subcutaneous tissue, skin was thin and fragile with loss of hair over scalp, eyebrows and eyelashes, and his face was dismorphic with prominent eyes, beaked nose, small jaw and large cranium with visible veins over it. His voice was thin and high pitched. Overall, this gives them an extremely aged nearly 70 -80 years old man look. The patient was a known case of progeria syndrome and he was treated as a VIP patient by all faculty members and staff, though he belongs low socioeconomic status, no political issue with them. But still he was a VIP.

  5. Ocular manifestations in the Hutchinson-Gilford progeria syndrome

    Directory of Open Access Journals (Sweden)

    Shivcharan L Chandravanshi

    2011-01-01

    Full Text Available The Hutchinson-Gilford progeria (HGP syndrome is an extremely rare genetic condition characterized by an appearance of accelerated aging in children. The word progeria is derived from the Greek word progeros meaning ′prematurely old′. It is caused by de novo dominant mutation in the LMNA gene (gene map locus 1q21.2 and characterized by growth retardation and accelerated degenerative changes of the skin, musculoskeletal and cardiovascular systems. The most common ocular manifestations are prominent eyes, loss of eyebrows and eyelashes, and lagophthalmos. In the present case some additional ocular features such as horizontal narrowing of palpebral fissure, superior sulcus deformity, upper lid retraction, upper lid lag in down gaze, poor pupillary dilatation, were noted. In this case report, a 15-year-old Indian boy with some additional ocular manifestations of the HGP syndrome is described.

  6. Foundational biomedical informatics research in the clinical and translational science era: a call to action.

    Science.gov (United States)

    Payne, Philip R O; Embi, Peter J; Niland, Joyce

    2010-01-01

    Advances in clinical and translational science, along with related national-scale policy and funding mechanisms, have provided significant opportunities for the advancement of applied clinical research informatics (CRI) and translational bioinformatics (TBI). Such efforts are primarily oriented to application and infrastructure development and are critical to the conduct of clinical and translational research. However, they often come at the expense of the foundational CRI and TBI research needed to grow these important biomedical informatics subdisciplines and ensure future innovations. In light of this challenge, it is critical that a number of steps be taken, including the conduct of targeted advocacy campaigns, the development of community-accepted research agendas, and the continued creation of forums for collaboration and knowledge exchange. Such efforts are needed to ensure that the biomedical informatics community is able to advance CRI and TBI science in the context of the modern clinical and translational science era.

  7. Biomechanical Strain Exacerbates Inflammation on a Progeria-on-a-Chip Model

    NARCIS (Netherlands)

    Ribas, J.; Zhang, Y.S.; Pitrez, P.R.; Leijten, Jeroen Christianus Hermanus; Miscuglio, M.; Rouwkema, Jeroen; Dokmeci, M.R.; Nissan, X.; Ferreira, L.; Khademhosseini, A.

    2017-01-01

    A progeria-on-a-chip model is engineered to recapitulate the biomechanical dynamics of vascular disease and aging. The model shows an exacerbated injury response to strain and is rescued by pharmacological treatments. The progeria-on-a-chip is expected to drive the discovery of new drugs and to

  8. A prospective study of radiographic manifestations in Hutchinson-Gilford progeria syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Cleveland, Robert H. [Harvard Medical School, Pediatric Radiology, Children' s Hospital Boston, Boston, MA (United States); Gordon, Leslie B. [Harvard Medical School, Department of Anesthesia, Children' s Hospital Boston, Boston, MA (United States); Warren Alpert Medical School of Brown University, Department of Pediatrics, Hasbro Children' s Hospital, Providence, RI (United States); Kleinman, Monica E. [Harvard Medical School, Department of Anesthesia, Children' s Hospital Boston, Boston, MA (United States); Miller, David T. [Harvard Medical School, Division of Genetics, Children' s Hospital Boston, Boston, MA (United States); Gordon, Catherine M. [Harvard Medical School, Division of Endocrinology and Adolescent Medicine, Children' s Hospital Boston, Boston, MA (United States); Snyder, Brian D. [Harvard Medical School, Department of Orthopedic Surgery, Children' s Hospital Boston, Boston, MA (United States); Nazarian, Ara [Harvard Medical School, Boston, MA (United States); Giobbie-Hurder, Anita [Dana-Farber Cancer Institute, Department of Biostatistics and Computational Biology, Boston, MA (United States); Neuberg, Donna [Dana-Farber Cancer Institute, Department of Biostatistics and Computational Biology, Boston, MA (United States); Harvard School of Public Health, Department of Biostatistics, Boston, MA (United States); Kieran, Mark W. [Dana-Farber Cancer Institute and Children' s Hospital Boston, Division of Pediatric Oncology, Boston, MA (United States)

    2012-09-15

    Progeria is a rare segmental premature aging disease with significant skeletal abnormalities. Defining the full scope of radiologic abnormalities requires examination of a large proportion of the world's progeria population (estimated at 1 in 4 million). There has been no comprehensive prospective study describing the skeletal abnormalities associated with progeria. To define characteristic radiographic features of this syndrome. Thirty-nine children with classic progeria, ages 2-17 years, from 29 countries were studied at a single site. Comprehensive radiographic imaging studies were performed. Sample included 23 girls and 16 boys - the largest number of patients with progeria evaluated prospectively to date. Eight new and two little known progeria-associated radiologic findings were identified (frequencies of 3-36%). Additionally, 23 commonly reported findings were evaluated. Of these, 2 were not encountered and 21 were present and ranked according to their frequency. Nine abnormalities were associated with increasing patient age (P = 0.02-0.0001). This study considerably expands the radiographic morphological spectrum of progeria. A better understanding of the radiologic abnormalities associated with progeria and improved understanding of the biology of progerin (the molecule responsible for this disease), will improve our ability to treat the spectrum of bony abnormalities. (orig.)

  9. ”Generalizability” as Recognition: Reflections on a Foundational Problem in Qualitative Research

    Directory of Open Access Journals (Sweden)

    Charlotte Delmar

    2010-10-01

    Full Text Available The aim of the article is to develop what counts as “generalizability” in qualitative research. By taking an ontological and epistemic stance in relation to the four foundational problems: 1Knowledge and its various forms. 2 Properties of reality and the doubleness of the situation. 3 How is understanding possible? 4 The researcher’s role: What are the fundamental questions that the researcher must ask himself before a study is designed? we are able to approach the exploration of ”generalizability” in qualitative research. Methodological theorists agree that the question of applicability is essential in the discussion of “generalizability” in qualitative research. If the quantitative tradition’s requirement for replicability also has to be met, the pressing question during the article is what counts as replicability and applicability in qualitative research. In the exploration of what is involved in “generalizability” in qualitative research a combination of Gadamer and Flyvbjerg´s thinking are important sources for a reflection on the ontological and epistemic questions related to the four foundational problems. The ontological question of what establishes a situation is an essential interpretation for the finding. A situation is characterised by its quality of doubleness: it is unique and typical at the same time. People with each their unique story and life world constitute the uniqueness of the situation. And a situation is typical in the sense that fundamental experiences can be found in every situation. The typical is what we as people have in common. There will be typical traits and recogizable patterns in every situation. The finding show us that “generalizability” in qualitative research builds on recognisability and a challenge to practice as a practical reasoning.

  10. Scleroderma Foundation

    Science.gov (United States)

    ... Scleroderma Scleroderma Researcher Profile - Peter Wemuth, Ph.D. Messenger of Hope Award 2017 Nursing Survey - American Thoracic ... to access our FY 2015-16 Annual Report! Facebook Scleroderma Foundation E-Newsletter Signup Get the latest ...

  11. Integrated corridor management concept development and foundational research. Task 3.2, develop criteria for delineating a corridor

    Science.gov (United States)

    2006-04-12

    Task 3 involves overall foundational research to further the understanding of various aspects of Integrated Corridor Management (ICM) and to identify integration issues needed to evaluate the feasibility of the ICM initiative. The focus of Task 3.2 a...

  12. Behavioral science foundations of the Rorschach test: research and clinical applications.

    Science.gov (United States)

    Acklin, M W

    1999-12-01

    Never without its critics, the Rorschach Test continues to be widely used in clinical settings. The test continues to be criticized vigorously. Rorschach critics appear to fall into two broad groups: those leveling valid methodological concerns about the test s behavioral science foundations and method critics who appear to deny the validity of the test on strictly a priori or theoretical considerations. Many critics do not appear to be acquainted with the extensive Rorschach research literature. The current paper provides an overview of several domains of applied and laboratory Rorschach behavioral science, including statistical power analysis, interobserver agreement and interrater reliability, Rorschach assessment of thought disorder, and emerging research linking Rorschach variables with diagnostic criteria from the DSM-IV, as a means of educating both adherents and detractors alike concerning the test s scientific track record and applicability to clinical assessment.

  13. The Ontology of Clinical Research (OCRe): an informatics foundation for the science of clinical research

    National Research Council Canada - National Science Library

    Sim, Ida; Tu, Samson W; Carini, Simona; Lehmann, Harold P; Pollock, Brad H; Peleg, Mor; Wittkowski, Knut M

    2014-01-01

    .... The activities of these scientific processes - the science of clinical research - are centered on the study protocol, which is the abstract representation of the scientific design of a clinical study...

  14. Eclecticism as the foundation of meta-theoretical, mixed methods and interdisciplinary research in social sciences.

    Science.gov (United States)

    Kroos, Karmo

    2012-03-01

    This article examines the value of "eclecticism" as the foundation of meta-theoretical, mixed methods and interdisciplinary research in social sciences. On the basis of the analysis of the historical background of the concept, it is first suggested that eclecticism-based theoretical scholarship in social sciences could benefit from the more systematic research method that has been developed for synthesizing theoretical works under the name metatheorizing. Second, it is suggested that the mixed methods community could base its research approach on philosophical eclecticism instead of pragmatism because the basic idea of eclecticism is much more in sync with the nature of the combined research tradition. Finally, the Kuhnian frame is used to support the argument for interdisciplinary research and, hence, eclecticism in social sciences (rather than making an argument against multiple paradigms). More particularly, it is suggested that integrating the different (inter)disciplinary traditions and schools into one is not necessarily desirable at all in social sciences because of the complexity and openness of the research field. If it is nevertheless attempted, experience in economics suggests that paradigmatic unification comes at a high price.

  15. SERI's photovoltaic research project: A foundation for tomorrow's utility-scale electricity

    Science.gov (United States)

    Mitchell, R. L.; Surek, T.

    1988-05-01

    Recent progress and future directions in PV research managed by SERI for the U.S. Department of Energy (DOE) are reviewed. The primary emphases of the research are on thin-film single-junction and multijunction devices. However, work also continues on advanced crystalline silicon sheet materials. Improvements in materials and processing, solar cell design, and cell fabrication techniques have led to continuing improvements in cell efficiencies in nearly all material areas. Recent research has identified the criticality of source-material purity and device-processing conditions for different PV materials. Attention to total device design and processing has increased understanding of metallic contacts, transparent conductors, and intermediate layers. Sophisticated models have been developed to quickly assess device concepts. Enhanced measurement and characterization techniques, along with increased interactions among PV scientists, are adding to the strong foundation of photovoltaics. Future directions in PV research are given in the recent Five Year Research Plan prepared by DOE. The plan is predicated on partnerships among the Federal government, private firms, universities, and electric utilities. As part of a consensus review of the plan, this multifaceted PV community identified the specific technical goals and pertinent R and D needed for success. These technical goals and future research are described in detail.

  16. Identifying Research Priorities: Themes and Directions for the TESOL International Research Foundation.

    Science.gov (United States)

    Tucker, G. Richard; Lightbown, Patsy M.; Snow, Catherine; Christian, Donna; de Bot, Kees; Lynch, Brian K.; Nunan, David; Duff, Patricia A.; Freeman, Donald; Bailey, Kathleen M.

    2001-01-01

    Highlights research priorities for the Teaching English to Speakers of Other Languages (TESOL) field, including the following: age of beginning instruction, learning to read in a second language, dual-language education for English language learners, language assessment and program evaluation, English as a global language, learning English for…

  17. Research in Social Work and Foundations of the Marxian Theoretical-Methodological Perspective

    Directory of Open Access Journals (Sweden)

    Adilson Aquino Silveira Júnior

    2012-12-01

    Full Text Available This article analyzes the investigative foundation provided by Marx to his theoretical-methodological categories, that is, how to operate the relationship between ontology, gnosiological process and method in his work. It highlights that the appropriation of a Marxian approach to ontology and method in research in Social Work is necessary to deepen the critical and emancipatory perspective of the profession. Based on the category of praxis, it reveals the organic ties between the ontological and methodological determinations in the process of production of knowledge, which imply the refusal of a formal-abstract position. Finally, it indicates that the perspective of concrete totality and of historicity make unviable any speculative and formalist separation of the method in relation to the contradictions of social life.

  18. Evaluation of the National Science Foundation's Partnerships for International Research and Education (PIRE) Program, Volume 2: Supplementary Materials. Final Report

    Science.gov (United States)

    Martinez, Alina; Epstein, Carter; Parsad, Amanda

    2015-01-01

    The National Science Foundation contracted with Abt Associates to conduct an evaluation of its Partnerships for International Research and Education (PIRE) program, which supports intellectually substantive collaborations between U.S. and foreign researchers in which the international partnership is essential to the research effort. The evaluation…

  19. Environmental Science and Research Foundation annual technical report to DOE-ID, January , 1995--December 31, 1995

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-06-01

    The foundation conducts an environmental monitoring and surveillance program over an area covering much of the upper Snake River Plain and provide environmental education and support services related to INEL natural resource issues. Also, the foundation, with its university affiliates, conducts ecological and radioecological research on the Idaho National Environmental Research Park. This research benefits major DOE-ID programs including waste management, environmental restoration, spent nuclear fuels, and land management issues. Major accomplishments during CY1995 can be divided into five categories: environmental surveillance program, environmental education, environmental services and support, ecological risk assessment, and research benefitting the DOE-ID mission.

  20. Hutchinson-Gilford Progeria Syndrome: A Rare Genetic Disorder

    Directory of Open Access Journals (Sweden)

    Rajat G. Panigrahi

    2013-01-01

    Full Text Available Hutchinson-Gilford progeria syndrome (HGPS is a rare pediatric genetic syndrome with incidence of one per eight million live births. The disorder is characterised by premature aging, generally leading to death at approximately 13.4 years of age. This is a follow-up study of a 9-year-old male with clinical and radiographic features highly suggestive of HGPS and presented here with description of differential diagnosis and dental consideration. This is the first case report of HGPS which showed pectus carinatum structure of chest.

  1. Hutchinson - Gilford progeria syndrome: A rare case report

    Directory of Open Access Journals (Sweden)

    Subhash Kashyap

    2014-01-01

    Full Text Available Hutchinson - Gilford Progeria Syndrome is a rare genetic disorder characterized by premature aging involving the skin, bones, heart, and blood vessels. We report a three-year-old boy with clinical manifestations characteristic of this syndrome. He had a characteristic "plucked-bird" appearance, prominent eyes and scalp veins, senile look, loss of scalp hair, eyebrows, and eyelashes, stunted growth, and mottled pigmentation with sclerodermatous changes over the trunk and lower limbs. Radiological changes and decreased high-density lipoprotein (HDL levels were also characteristic of the syndrome. This interesting case is reported for its rarity.

  2. [Hutchinson-Gilford progeria. A rare case of neonatal occurrence].

    Science.gov (United States)

    Zucchini, A; Bonfiglioli, G; Masignà Ricciardi, M G

    1986-01-01

    A case of Hutchinson-Gilford progeria syndrome is described in which phenotypic and metabolic symptoms were already evident at birth. Both under a clinical and autopsy point of view an early old age of organs and apparatuses was apparent, posing the problem of the reason why an early old aging occurs. The authors mention literature in favour of a genetic control of cellular aging and make the assumption that the genes controlling old age are various and that a greater or lesser presence and incidence of them could justify the earlier or normal appearance of this status.

  3. A feminist critique of foundational nursing research and theory on transition to motherhood.

    Science.gov (United States)

    Parratt, Jenny A; Fahy, Kathleen M

    2011-08-01

    is using 'transition to motherhood theory' the best way to guide midwives in providing woman-centred care? contemporary research about changes to women's embodied sense of self during childbearing is influenced by foundational research and theory about the transition to motherhood. Rubin and Mercer are two key nursing authors whose work on transition to motherhood theory still shapes the ways in which a woman's experience of change during childbearing is understood in midwifery. using a feminist post-structural framework, Rubin and Mercer's theory and research is described, critiqued and discussed. Rubin and Mercer used pre-existing theories and concepts that had the effect of finding similarities and discarding differences between women. Rubin and Mercer's theory and research is an expression of humanistic philosophy. This philosophy creates frameworks that have an assumed, disempowered role for childbearing women. Their research used a logico-empirical, quantitative approach. Qualitative interpretive or constructivist approaches offer more appropriate ways to study the highly individualised, embodied, lived experience of a woman's changing self during childbearing. Rubin and Mercer's theory is baby-centred. Transition to motherhood theory privileges the position of experts in directing how a woman should become a mother. This has the effect of making midwives agents for the social control of women. Rubin and Mercer's transition to motherhood theory is a well-intentioned product of its time. The theory is inconsistent with contemporary midwifery philosophy which promotes a woman-centred partnership between the midwife and the woman. The usefulness of this outdated nursing theory in midwifery teaching, research or practice is debatable. Copyright © 2010 Elsevier Ltd. All rights reserved.

  4. Sensitivity, Specificity, and Predictive Values: Foundations, Pliabilities, and Pitfalls in Research and Practice

    Directory of Open Access Journals (Sweden)

    Robert Trevethan

    2017-11-01

    Full Text Available Within the context of screening tests, it is important to avoid misconceptions about sensitivity, specificity, and predictive values. In this article, therefore, foundations are first established concerning these metrics along with the first of several aspects of pliability that should be recognized in relation to those metrics. Clarification is then provided about the definitions of sensitivity, specificity, and predictive values and why researchers and clinicians can misunderstand and misrepresent them. Arguments are made that sensitivity and specificity should usually be applied only in the context of describing a screening test’s attributes relative to a reference standard; that predictive values are more appropriate and informative in actual screening contexts, but that sensitivity and specificity can be used for screening decisions about individual people if they are extremely high; that predictive values need not always be high and might be used to advantage by adjusting the sensitivity and specificity of screening tests; that, in screening contexts, researchers should provide information about all four metrics and how they were derived; and that, where necessary, consumers of health research should have the skills to interpret those metrics effectively for maximum benefit to clients and the healthcare system.

  5. [Review and analysis of transplant biological research projects funded by National Natural Science Foundation of China].

    Science.gov (United States)

    Gong, Weihua; Sun, Ruijuan; Dong, Erdan

    2015-08-01

    To study the funding and achievements in the field of organ transplantation support by the National Natural Science Foundation of China (NSFC). A search of NSFC database was made by using the key word "transplantation" and excluding "bone marrow transplantation" for the projects funded between 1988 and 2013. SCI indexed publications that marked with NSFC project number were collected by searching each grant number in the database of the Web of Science. Six hundreds fifty-five projects were identified and received about 220 million yuan in grant funding. These funded research projects were distributed among 25 provinces and autonomous regions, however, which were mainly in the developed coastal areas; of them, 43 (6.56%) projects were granted in xenotransplantation and 17 projects (2.60%) were funded in the field of traditional Chinese medicine-related organ transplantation; Transplantation on blood vessels, heart, kidney, liver, lung, small intestine, pancreatic, cornea, trachea, skin, etc. were primarily performed in research. Nine hundreds and sixty-one SCI-indexed publications were achieved. Magnitude and intensity of NSFC funding, output of SCI publications have been increasing, suggesting that NSFC positively promotes the development of organ transplantation. Although a great progress of transplantation has been made, basic and translational studies should be vigorously strengthened.

  6. The National Shipbuilding Research Program. A Common Sense Design Manual for Producibility of Hull Foundations

    Science.gov (United States)

    1996-06-01

    Purchasing to Engineering 3) Engineering to Composite 4) Engineering to Designers -McDERMOTT 1) Equipment/system owner identifies equipment 2) Compositor ...uses detail data plus equipment model to develop foundation in model 5) Compositor checks completed foundation in model for fouls -NNs The department

  7. Adaptive stress response in segmental progeria resembles long-lived dwarfism and calorie restriction in mice

    NARCIS (Netherlands)

    van de Ven, Marieke; Andressoo, Jaan-Olle; Holcomb, Valerie B.; von Lindern, Marieke; Jong, Willeke M. C.; de Zeeuw, Chris I.; Suh, Yousin; Hasty, Paul; Hoeijmakers, Jan H. J.; van der Horst, Gijsbertus T. J.; Mitchell, James R.

    2006-01-01

    How congenital defects causing genome instability can result in the pleiotropic symptoms reminiscent of aging but in a segmental and accelerated fashion remains largely unknown. Most segmental progerias are associated with accelerated fibroblast senescence, suggesting that cellular senescence is a

  8. Building America Special Research Project—High-R Foundations Case Study Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Jonathan Smegal/John Straube

    2010-08-20

    This report considers a number of promising foundation and basement insulation strategies that can meet the requirement for better thermal control in colder climates while enhancing moisture control, health, and comfort.

  9. Research Misconduct in National Science Foundation Funded Research: A Mixed-Methods Analysis of 2007-2011 Research Awards

    Science.gov (United States)

    Masters, Elizabeth A.

    2013-01-01

    Research is an important aspect of academic institutions as it brings funding, reputation, and other benefits to the associated establishment. Research misconduct in the form of plagiarism, fabrication, and falsification can occur in association with research, along with subsequent penalties. The problem of the poorly established prevalence of the…

  10. Starting Where the People Are: The African Medical and Research Foundation (AMREF). Carnegie Quarterly, Volume XXXII, Number 2.

    Science.gov (United States)

    Carnegie Quarterly, 1987

    1987-01-01

    This issue of the "Carnegie Quarterly" describes three projects that are being conducted by the African Medical and Research Foundation (AMREF). The projects are the following: (1) building community participation in health care at Lake Kenyatta; (2) the role of community education in disease control among the Turkana people at…

  11. 75 FR 62838 - Award of a Single-Source Expansion Supplement to the Research Foundation of CUNY on Behalf of...

    Science.gov (United States)

    2010-10-13

    ... HUMAN SERVICES Administration for Children and Families Award of a Single-Source Expansion Supplement to the Research Foundation of CUNY on Behalf of Hunter College School of Social Work AGENCY: Children's.... ] Project Period: September 30, 2010 to September 29, 2011. SUMMARY: The Administration for Children and...

  12. The Danish Industrial Foundations

    DEFF Research Database (Denmark)

    Thomsen, Steen

    Industrial foundations are foundations that own companies. Typically, they combine charitable and business goals. This book is about industrial foundation ownership of business companies and what we can learn about it from the Danish evidence. It is about how foundation ownership is ruled, taxed...... and governed, what role it plays in the Danish economy, and how industrial foundation-owned companies perform. The book is the result of a large collaborative research project, led by the author, on industrial foundations. Some global companies such as IKEA, Robert Bosch or the Tata Group are foundation...

  13. The Hub and the Spokes: Foundations, Intermediary Organizations, Incentivist Reforms, and the Politics of Research Evidence

    Science.gov (United States)

    Scott, Janelle; Jabbar, Huriya

    2014-01-01

    The rise in the influence of and spending by educational philanthropists and foundations over the past two decades, especially in the area of market-based reforms, such as charter schools, vouchers, and merit pay, is evident across the United States. Largely due to philanthropic investments, relatively new educational intermediary organizations…

  14. The Development of the Foundations of Modern Pedagogy: Paradigmal and Methodological Aspects of Research

    Science.gov (United States)

    Dmitrenko, ?amara ?.; Lavryk, Tatjana V.; Yaresko, Ekaterina V.

    2015-01-01

    Changes in the various fields of knowledge influenced the pedagogical science. The article explains the structure of the foundations of modern pedagogy through paradigmal and methodological aspects. Bases of modern pedagogy include complex of paradigms, object and subject of science, general and specific principles, methods and technologies.…

  15. National Kidney Foundation Newsroom

    Science.gov (United States)

    ... Kidney Foundation - 04/10/2017 National University of Malaysia Researcher Honored by National Kidney Foundation - 04/10/ ... Organizations”, a special report in The New England Journal of Medicine - 03/01/2017 Industry News New ...

  16. Building America Case Study: Cold Climate Foundation Wall Hygrothermal Research Facility, Cloquet, Minnesota (Fact Sheet)

    Energy Technology Data Exchange (ETDEWEB)

    NorthernSTAR

    2014-09-01

    This report focuses on the progress made to date and the technical details of the experiment. An overview of the experimental data being collected with some interesting highlights noted thus far is also provided. A full analysis of the experimental data and the drawing of conclusions with regard to the thermal and hygrothermal performance of the retrofit foundation insulation systems tested will only be possible after a full year of data has been collected in 2014.

  17. The Research on Subsidence Prediction of Soils Around Deep Foundation Pit

    Directory of Open Access Journals (Sweden)

    Ge LIU

    2014-12-01

    Full Text Available Deep foundation pit will cause settlement of surround buildings in the process of excavation. When the settlement is excessive, it will give rise to safety issues. Subsidence monitoring has become an important measure to ensure the safety of deep foundation pits. But in current subsidence monitoring engineering, the costs of wiring, unwiring and installation are particularly high. This paper proposes a portable wireless data transmission device in forecasting and early warning of settlement deformation of soils around deep foundation pits. We solve the problem by adopting the means of wireless communication to replace the cable transmission link part. The device does not rely on any personal computers. Instead, it can directly deal with the collected data through grey prediction GM (1, 1 mathematical model, neural network and interpolation model to give short-term, medium- term and long-term forecasts, respectively. Additionally it is able to set a threshold value. Once the forecast data reach the threshold, the device can issue alert and achieve the target of reminding technicians, so as to provide reliable basis to prevent and reduce disasters.

  18. [The research course in geriatrics at the Robert Bosch Foundation--new scientific geriatric academicians from a German view].

    Science.gov (United States)

    Stähelin, H B

    2005-09-01

    The medical needs of the aging population, accentuated by demographic changes, are poorly reflected by the present academic medical training programs. Geriatric medicine does not receive the attention it should have to meet the rapidly increasing demands of the aging population. This is true for Germany but also for Switzerland and Austria as well as many other European countries. The Robert Bosch Foundation with the goal of improving social conditions and scientific competence through innovative projects is engaged in improving the situation of the aging population by a number of projects. Aware of the deficits in geriatric medicine and in response to the need of a training program in academic geriatric medicine, the Foundation initiated a research training program in Geriatrics in 2002 together with initially five now seven academic centers in Germany and Switzerland. The program is aimed at young researchers having graduated in medicine and interested in a career in academic geriatric medicine. Two types of grants are given: an early career award for young postdocs at the beginning of their scientific training for two years and a mid career stipend for medical scientists coming from other disciplines and interested in a career in geriatric medicine. The goal of the training program is developing competence in clinical research and in geriatric medicine. A research council advises the Foundation in the grant allocation and monitors the program as well as the individual progress of the award recipients. Currently, 10 trainees are in the program. The initiative of the Robert Bosch Foundation is an enormous help to establish academic geriatric medicine in Germany.

  19. Rescue of progeria in trichothiodystrophy by homozygous lethal Xpd alleles.

    Directory of Open Access Journals (Sweden)

    Jaan-Olle Andressoo

    2006-10-01

    Full Text Available Although compound heterozygosity, or the presence of two different mutant alleles of the same gene, is common in human recessive disease, its potential to impact disease outcome has not been well documented. This is most likely because of the inherent difficulty in distinguishing specific biallelic effects from differences in environment or genetic background. We addressed the potential of different recessive alleles to contribute to the enigmatic pleiotropy associated with XPD recessive disorders in compound heterozygous mouse models. Alterations in this essential helicase, with functions in both DNA repair and basal transcription, result in diverse pathologies ranging from elevated UV sensitivity and cancer predisposition to accelerated segmental progeria. We report a variety of biallelic effects on organismal phenotype attributable to combinations of recessive Xpd alleles, including the following: (i the ability of homozygous lethal Xpd alleles to ameliorate a variety of disease symptoms when their essential basal transcription function is supplied by a different disease-causing allele, (ii differential developmental and tissue-specific functions of distinct Xpd allele products, and (iii interallelic complementation, a phenomenon rarely reported at clinically relevant loci in mammals. Our data suggest a re-evaluation of the contribution of "null" alleles to XPD disorders and highlight the potential of combinations of recessive alleles to affect both normal and pathological phenotypic plasticity in mammals.

  20. Factors impacting successfully competing for research funding: an analysis of applications submitted to the Plastic Surgery Foundation.

    Science.gov (United States)

    Hume, Keith M; Giladi, Aviram M; Chung, Kevin C

    2015-02-01

    Federal research funding is decreasing, forcing specialty organizations to have an increasingly important position in developing and fostering research. As the research and innovation arm of the American Society of Plastic Surgeons, The Plastic Surgery Foundation has a key role in supporting promising plastic surgery research. Understanding the grant review process and factors that contribute to funding well-written grant funding applications is essential for aspiring academic surgeons. All research grant applications submitted to The Plastic Surgery Foundation in 2012 and 2013 were evaluated. Each reviewer comment was assessed independently by two study team members and classified into key weakness categories. The chi-square test was used to compare results between funded and unfunded grants. Linear regression identified which critique elements corresponded to changes in scores, and logistic regression identified elements that predicted funding. The authors analyzed 1764 comments from 240 applications. Of these, 55 received funding. Funded grants had significantly fewer reviewer comments in four of five weakness categories. As expected, funded grants received better (lower) scores. Concerns in the categories of plan for execution and other elements/grantsmanship significantly affected score and odds of funding. Ensuring that a grant addresses all required elements is important for receiving a low reviewer score. Our study demonstrates that plan for execution and grantsmanship influence reviewer scoring more than others. Investigators must clearly address items associated with conducting their experiments and performing the analysis. Investigators must also give equal attention to elements of overall quality and completeness to optimize chances of funding.

  1. Research following a foundation in the applied optics group at University of Kent

    Science.gov (United States)

    Kersey, Alan D.

    2011-06-01

    This paper summarizes research activities at University of Kent over the period from September 1981 through November 1984. Subsequent researches undertaken in the US Naval Research Laboratory and two start-up companies are also described.

  2. Cold Climate Foundation Retrofit Experimental Hygrothermal Performance. Cloquet Residential Research Facility Laboratory Results

    Energy Technology Data Exchange (ETDEWEB)

    Goldberg, Louise F. [NorthernSTAR, St. Paul, MN (United States); Harmon, Anna C. [NorthernSTAR, St. Paul, MN (United States)

    2015-04-09

    This project was funded jointly by the National Renewable Energy Laboratory (NREL) and Oak Ridge National Laboratory (ORNL). ORNL focused on developing a full basement wall system experimental database to enable others to validate hygrothermal simulation codes. NREL focused on testing the moisture durability of practical basement wall interior insulation retrofit solutions for cold climates. The project has produced a physically credible and reliable long-term hygrothermal performance database for retrofit foundation wall insulation systems in zone 6 and 7 climates that are fully compliant with the performance criteria in the 2009 Minnesota Energy Code. These data currently span the period from November 10, 2012 through May 31, 2014 and are anticipated to be extended through November 2014. The experimental data were configured into a standard format that can be published online and that is compatible with standard commercially available spreadsheet and database software.

  3. A lamin A protein isoform overexpressed in Hutchinson–Gilford progeria syndrome interferes with mitosis in progeria and normal cells

    Science.gov (United States)

    Cao, Kan; Capell, Brian C.; Erdos, Michael R.; Djabali, Karima; Collins, Francis S.

    2007-01-01

    Hutchinson–Gilford progeria syndrome (HGPS) is a rare genetic disorder characterized by dramatic premature aging. Classic HGPS is caused by a de novo point mutation in exon 11 (residue 1824, C → T) of the LMNA gene, activating a cryptic splice donor and resulting in a mutant lamin A (LA) protein termed “progerin/LAΔ50” that lacks the normal cleavage site to remove a C-terminal farnesyl group. During interphase, irreversibly farnesylated progerin/LAΔ50 anchors to the nuclear membrane and causes characteristic nuclear blebbing. Progerin/LAΔ50's localization and behavior during mitosis, however, are completely unknown. Here, we report that progerin/LAΔ50 mislocalizes into insoluble cytoplasmic aggregates and membranes during mitosis and causes abnormal chromosome segregation and binucleation. These phenotypes are largely rescued with either farnesyltransferase inhibitors or a farnesylation-incompetent mutant progerin/LAΔ50. Furthermore, we demonstrate that small amounts of progerin/LAΔ50 exist in normal fibroblasts, and a significant percentage of these progerin/LAΔ50-expressing normal cells are binucleated, implicating progerin/LAΔ50 as causing similar mitotic defects in the normal aging process. Our findings present evidence of mitotic abnormality in HGPS and may shed light on the general phenomenon of aging. PMID:17360355

  4. The New Aphrodite school on Disasters Food and Poverty organized by CIMA Research Foundation and University of Genova

    Science.gov (United States)

    Boni, G.

    2009-04-01

    CIMA is a Research Foundation which aim is to advance science and engineering in environmentally related fields, focusing on public health and safety, civil protection and the preservation of terrestrial and water-related ecosystems. This aim is accomplished through scientific research, technology transfer and high level training services. Here we present the "New Aphrodite school on Disasters Food and Poverty" jointly managed by CIMA Foundation, and the University of Genova. The school is organized to provide to international students, professionals and government officials, mainly from poor or developing countries, formation for the management, prediction and prevention of natural and man made disasters. The expertise of the teachers, mainly CIMA's researchers, comes from a long term support of CIMA Foundation to the Italian Civil Protection in developing the advanced national system for risk prediction, prevention and management. The school is organized in two levels. The first level includes an international master of science degree in "Environmental Engineering: Sustainable Development and Risk Management", which classes are given in English, and a master for professional and government officials in "Disasters, food and poverty". The second level includes an international Ph.D. programme in "Information sciences and technologies for system monitoring and environmental risk management". Short training courses for international government official are periodically organized. At present the school is organizing short courses for officials of Civil Protections of Venezuela, Barbados and Mozambique. The philosophy underlying the teaching activities is to promote a multi-disciplinary approach to disaster mitigation, prevention and prediction. Special focus is on the potential of high-tech low-cost technologies for rapid communication and disaster monitoring, such as satellite based technologies. Such technologies are seen as the best way to support the development

  5. The Start-Up Phase in a Research and Development Work Project: A Foundation for Development

    Science.gov (United States)

    Postholm, May Britt

    2008-01-01

    The article is based on a research and development work project (R&D project) conducted in a Norwegian lower secondary school. The purpose of the text is to describe the researchers' and teachers' roles during the initial phase of such a project, and what this phase and the close cooperation between the researcher and teachers mean for the…

  6. Takina te Kawa: Laying the Foundation, a Research Engagement Methodology in Aotearoa (New Zealand)

    Science.gov (United States)

    Taiwhati, Marama; Toia, Rawiri; Te Maro, Pania; McRae, Hiria; McKenzie, Tabitha

    2010-01-01

    In the bi-cultural context of Aotearoa (New Zealand), engagement with stakeholders that is transparent and culturally responsive is a priority for educational research. More common research approaches in New Zealand have followed a Western euro-centric model of engagement with research participants resulting in interventions and initiatives that…

  7. Cold Climate Foundation Retrofit Experimental Hygrothermal Performance: Cloquet Residential Research Facility Laboratory Results

    Energy Technology Data Exchange (ETDEWEB)

    Goldberg, Louise F. [NorthernSTAR, St. Paul, MN (United States); Harmon, Anna C. [NorthernSTAR, St. Paul, MN (United States)

    2015-04-01

    Thermal and moisture problems in existing basements create a unique challenge because the exterior face of the wall is not easily or inexpensively accessible. This approach addresses thermal and moisture management from the interior face of the wall without disturbing the exterior soil and landscaping. the interior and exterior environments. This approach has the potential for improving durability, comfort, and indoor air quality. This project was funded jointly by the National Renewable Energy Laboratory (NREL) and Oak Ridge National Laboratory (ORNL). ORNL focused on developing a full basement wall system experimental database to enable others to validate hygrothermal simulation codes. NREL focused on testing the moisture durability of practical basement wall interior insulation retrofit solutions for cold climates. The project has produced a physically credible and reliable long-term hygrothermal performance database for retrofit foundation wall insulation systems in zone 6 and 7 climates that are fully compliant with the performance criteria in the 2009 Minnesota Energy Code. The experimental data were configured into a standard format that can be published online and that is compatible with standard commercially available spreadsheet and database software.

  8. Compound heterozygosity for mutations in LMNA causes a progeria syndrome without prelamin A accumulation.

    NARCIS (Netherlands)

    Verstraeten, V.L.; Broers, J.L.; Steensel, M.A.M. van; Zinn-Justin, S.; Ramaekers, F.C.S.; Steijlen, P.M.; Kamps, M.; Kuijpers, H.J.; Merckx, D.; Smeets, H.J.M.; Hennekam, R.C.M.; Marcelis, C.L.M.; Wijngaard, A. van de

    2006-01-01

    LMNA-associated progeroid syndromes have been reported with both recessive and dominant inheritance. We report a 2-year-old boy with an apparently typical Hutchinson-Gilford progeria syndrome (HGPS) due to compound heterozygous missense mutations (p.T528M and p.M540T) in LMNA. Both mutations affect

  9. The two-faced progeria gene and its implications in aging and metabolism

    NARCIS (Netherlands)

    Chatzispyrou, Iliana A.; Houtkooper, Riekelt H.

    2014-01-01

    Premature aging syndromes have gained much attention, not only because of their devastating symptoms but also because they might hold a key to some of the mechanisms underlying aging. The Hutchinson-Gilford progeria syndrome (HGPS) is caused by a mutation in the LMNA gene, which normally produces

  10. Compound heterozygosity for mutations in LMNA causes a progeria syndrome without prelamin A accumulation

    NARCIS (Netherlands)

    Verstraeten, Valerie L. R. M.; Broers, Jos L. V.; van Steensel, Maurice A. M.; Zinn-Justin, Sophie; Ramaekers, Frans C. S.; Steijlen, Peter M.; Kamps, Miriam; Kuijpers, Helma J. H.; Merckx, Diane; Smeets, Hubert J. M.; Hennekam, Raoul C. M.; Marcelis, Carlo L. M.; van den Wijngaard, Arthur

    2006-01-01

    LMNA-associated progeroid syndromes have been reported with both recessive and dominant inheritance. We report a 2-year-old boy with an apparently typical Hutchinson-Gilford progeria syndrome (HGPS) due to compound heterozygous missense mutations (p.T528M and p.M540T) in LMNA. Both mutations affect

  11. Survivor-Controlled Research: A New Foundation for Thinking about Psychiatry and Mental Health

    Directory of Open Access Journals (Sweden)

    Jasna Russo

    2012-01-01

    Full Text Available Survivor-controlled research in the field of mental health can be perceived as the most extended development of participatory research. This is not only because it does away with the role of research subjects, but because the experiential knowledge (as opposed to clinical acquires a central role throughout the whole research process—from the design to the analysis and the interpretation of outcomes stages. The first part of this article provides some background information about the context and development of user/survivor-controlled research in the UK. In the second part, the discussion focuses on the first two German studies which apply this research methodology in the field of psychiatry. Both studies are used as examples of the approach, which favors closeness to the subject as opposed to "scientific distance." The overall objective of this paper is to outline the general achievements and challenges of survivor-controlled research. Arguing for the value of this research approach I hope to demonstrate the ways in which it raises fundamental issues related to conventional knowledge production and challenges the nature of what counts as psychiatric evidence. URN: http://nbn-resolving.de/urn:nbn:de:0114-fqs120187

  12. Collaborative action research for the governance of climate adaptation - foundations, conditions and pitfalls

    NARCIS (Netherlands)

    Huntjens, P.M.J.M.; Termeer, C.J.A.M.; Eshuis, J.; Buuren, van M.

    2011-01-01

    This position paper serves as an introductory guide to designing and facilitating an action research process with stakeholders in the context of climate adaptation. Specifically, this is aimed at action researchers who are targeting at involving stakeholders and their expert knowledge in generating

  13. The Delaware River Basin Collaborative Environmental Monitoring and Research Initiative: Foundation Document

    Science.gov (United States)

    Peter S. Murdoch; Jennifer C. Jenkins; Richard A. Birdsey

    2008-01-01

    The U.S. Forest Service, the U.S. Geological Survey, and the National Park Service formed the Collaborative Environmental Monitoring and Research Initiative (CEMRI) to test strategies for integrated environmental monitoring among the agencies. The initiative combined monitoring and research efforts of the participating Federal programs to evaluate health and...

  14. Integrated corridor management : phase I, concept development and foundational research. Task 3.4, identify integrated corridor management institutional strategies and administration

    Science.gov (United States)

    2006-04-12

    Task 3 involves overall foundational research to further the understanding of various aspects of Integrated Corridor Management (ICM) and to identify integration issues needed to evaluate the feasibility of the ICM initiative. The focus of Task 3.4 a...

  15. Diabetic nephropathy research in China: Data analysis and review from the National Natural Science Foundation of China.

    Science.gov (United States)

    Wan, Qiang; Xu, Yanying; Dong, Erdan

    2015-05-01

    As the largest funding agency of natural science of China, the National Natural Science Foundation of China (NSFC) has made great efforts in promoting the development of diabetic nephropathy (DN) research in recent years. The aim of the current study is to summarize the diabetic nephropathy research in China by analyzing NSFC-funded projects. Data on all projects in the DN field funded by NSFC from 1986 to 2013 were collected. The funding tendency, funding areas, and hotspots in the DN field, and major research institutions, were analyzed. As one output of this support, outstanding research groups in China, and their representative studies, are also highlighted. From 1986 to 2013, the NSFC has funded a total of 248 projects in the DN field, with a total funding amount of 91.5 million RMB (US$14.9 million). A rapid increase could be seen in the past 5 years, with an average annual 30% increase in projects numbers and a 52% increase in funding amount. All fields in DN research have been covered by the NSFC, including etiology, pathophysiology, diagnostics, and therapeutics. Along with increased funding of the DN research, there has been a growth in the papers published in Science Citation Index journals by Chinese scholars. In the past decade, the funding scale and funding budget have increased dramatically. Benefiting from this, DN research in China has also made considerable progression. © 2015 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and Wiley Publishing Asia Pty Ltd.

  16. Comparing the Research Contributions of Community Pharmacy Foundation Funding on Practice Innovation Between Non-Academics and Academics

    Directory of Open Access Journals (Sweden)

    Anthony W Olson

    2017-07-01

    Full Text Available Objective: Evaluate and compare the research contributions of Community Pharmacy Foundation (CPF funding on community pharmacy practice innovation between non-academic and academic principal investigators (PIs with respect to the following measurements: 1 “Pharmacy Practice Activity Classifications” (PPAC; 2 CPF “Coordinated Use of Medications”; and 3 CPF Investigator Impact. Methods: Quantitative data for all 124 CPF-funded grants awarded from 2002-2016 were obtained from the CPF website and personnel, while ethnographic qualitative data was generated from queries of PIs. Grant categorization was conducted by researchers serving as judges trained on the rules and procedures for coding. A threshold level of 90% agreement in scores of independent judging was established a priori. Findings were summarized and groups were compared using descriptive statistics for quantitative data and a thematic analysis of PI ethnographic reflections for qualitative data. Results: There were no differences between non-academic and academic PI groups for Coordinated Use of Medications and PPAC domains, but non-academics contributed more to two dispensing-related PPAC subclasses: ‘Preparing the Product’ (10% vs. 2% and ‘Delivering the Medication or Device’ (13% vs. 2%. Analysis of investigator reflections revealed similarities between groups regarding impact on practice innovations, expanded collaborations, new practice tools, and patient-care financing models. Conclusions: CPF funding contributed new knowledge and resources for expanding and enhancing practice innovations as shown by quantitative (PPAC & Coordinated Use of Medications and qualitative (PI impact measures. Similarities between PI groups suggest that the CPF has established a funding niche with unique diversity of practice innovation opportunities. This investigation’s findings may be useful to the CPF’s continuous quality improvement efforts, as well as future grant applicants to

  17. Neuroplasticity of selective attention: Research foundations and preliminary evidence for a gene by intervention interaction.

    Science.gov (United States)

    Isbell, Elif; Stevens, Courtney; Pakulak, Eric; Hampton Wray, Amanda; Bell, Theodore A; Neville, Helen J

    2017-08-29

    This article reviews the trajectory of our research program on selective attention, which has moved from basic research on the neural processes underlying selective attention to translational studies using selective attention as a neurobiological target for evidence-based interventions. We use this background to present a promising preliminary investigation of how genetic and experiential factors interact during development (i.e., gene × intervention interactions). Our findings provide evidence on how exposure to a family-based training can modify the associations between genotype (5-HTTLPR) and the neural mechanisms of selective attention in preschool children from lower socioeconomic status backgrounds.

  18. An Xpd mouse model for the combined xeroderma pigmentosum/Cockayne syndrome exhibiting both cancer predisposition and segmental progeria.

    NARCIS (Netherlands)

    Andressoo, Jaan-Olle; Mitchell, James R; Wit, Jan de; Hoogstraten, Deborah; Volker, Marcel; Toussaint, Wendy; Speksnijder, Ewoud; Beems, Rudolf B; Steeg, Harry van; Jans, Judith; Zeeuw, Chris I de; Jaspers, Nicolaas G J; Raams, Anja; Lehmann, Alan R; Vermeulen, Wim; Hoeijmakers, Jan H J; Horst, Gijsbertus T J van der

    2006-01-01

    Inborn defects in nucleotide excision DNA repair (NER) can paradoxically result in elevated cancer incidence (xeroderma pigmentosum [XP]) or segmental progeria without cancer predisposition (Cockayne syndrome [CS] and trichothiodystrophy [TTD]). We report generation of a knockin mouse model for the

  19. Monsef Benkirane awarded 2013 Ming K. Jeang Foundation Retrovirology Prize: landmark HIV-1 research honoured

    NARCIS (Netherlands)

    Berkhout, Ben; Lever, Andrew; Wainberg, Mark; Fassati, Ariberto; Borrow, Persephone; Fujii, Masahiro

    2013-01-01

    Dr. Monsef Benkirane, from the Laboratoire de Virologie Moleculaire in Montpellier, France, has been announced as the recipient of the 2013 Retrovirology Prize. This bi-annual prize covers all aspects of the Retrovirology field and celebrates groundbreaking research from retrovirologists aged

  20. Foundational Research in Behavioral and Social Sciences: Marching Towards the Future

    Science.gov (United States)

    2014-07-01

    determinants of the Army’s adaptability in a dynamic geo- political context. The overarching goal of this research portfolio is to develop theories...strength, cultural memes , cultural artifacts, norms, beliefs, and behaviors. The program also seeks to identify the sources of change in culture and

  1. Laying the Foundation: Institutional Research Office Organization, Staffing, and Career Development

    Science.gov (United States)

    Leimer, Christina; Terkla, Dawn Geronimo

    2009-01-01

    Staffing is a fundamental component of effective institutional research, yet determining and securing adequate resources can be difficult. In addition, as was noted in an AIR Forum presentation on the Achieving the Dream project (Rincones and Champion, 2008), even when colleges allocate money for positions they have difficulty finding…

  2. Snapshots of what, exactly? A comment on methodological experimentation and conceptual foundations in place research

    Science.gov (United States)

    Daniel R. Williams; Michael E. Patterson

    2007-01-01

    Place ideas in natural resource management have grown in recent years. But with that growth have come greater complexity and diversity in thinking and mounting confusion about the ontological and epistemological assumptions underlying any specific investigation. Beckley et al. (2007) contribute to place research by proposing a new methodological approach to analyzing...

  3. Joint research to build a foundation for nuclear cooperation between Korea and China (KINS-NNSA)

    Energy Technology Data Exchange (ETDEWEB)

    Chung, J. K. [Korea Atomic Energy Research Institute, Taejeon (Korea); Park, D. K.; Eun, Y. S.; Lee, J. I.; Park, Y. S.; Song, I. J.; Bang, Y. S.; Hyun, C. H.; Jung, D. W.; Jung, J. W.; Lee, J. H.; Kang, S. C.; Lee, S. H.; Kim, H. Y.; Ryu, Y. H.; Bae, K H.; Ahn, S. H.; Jo, D. H. [Korea Institute of Nuclear Safety, Taejeon (Korea)

    2000-03-01

    In order to strengthen and effectively perform nuclear cooperation between Korea and China. This joint research is not only to develop cooperative programme but also to establish implementation direction for the cooperation between KINS and NNSA as nuclear regulatory bodies. Through this research; 1) Regulatory system, organization, function, and activities of Chinese regulatory bodies could be identified. 2) Both institutions agreed to follow cooperative programmes for nuclear safety, such as: - held annually regular meeting on technical informations and experts exchange - Immediate exchange the informations on NPP operational events each other and establishment of channel for this purpose - Immediate notification each other in the radiological nuclear accident and establishment of channel for this purpose - Cooperative safety research for mutual interests in the field of nuclear safety analysis technology 3) It is understood each other that both institutions will make into effort bilateral cooperation between Korea and China to advance triple cooperation among Korea, China and Japan. It is thought that this research makes nuclear safety cooperation between the two assist export of our predominant technology to China in the future. 7 refs., 5 tabs. (Author)

  4. Entry to Vocations: Building the Foundations for Successful Transitions. Research Report

    Science.gov (United States)

    Clarke, Kira

    2014-01-01

    Vocational education and training (VET) in Schools is intended to provide young people with an opportunity to develop skills for a range of vocational occupations as they complete their senior secondary certificates. This report draws together findings from all three years of the "Entry to Vocations" research project and presents a set…

  5. As the bell tolls: a foundation study on pancreatic cancer consumer's research priorities

    Directory of Open Access Journals (Sweden)

    Gooden Helen

    2009-09-01

    Full Text Available Abstract Background This is the first investigation of its kind to explore the views of people affected by pancreatic cancer with regard to research priorities. Pancreatic cancer has an extremely poor outlook in terms of early diagnosis, effective treatment and survival. Those affected by the disease generally lack opportunities to voice their needs or concerns in an organised manner, link with others affected by the condition and take part in research. Methods This qualitative study adopts a self-selected telephone focussed discussion group approach. Information was obtained from distinct carer and patient groups after adequate controls such as the 'safe space' technique (repeatedly enquiring on and respecting the emotional needs were implemented to protect participants from undue physical and psychological distress. Results Five themes emerged overall, with three themes being common between the patients and carers groups. Early detection, clinician communication and public awareness were areas of recurring discussion and consensus for both groups. The fourth theme to emerge for the patient group centred on quality of care, while the fourth theme of the carer group focused on the need for more and improved treatment options. Conclusion Research priorities for pancreatic cancer consumers have been identified via an investigation that was tailored to meet exceptional needs. This research gives us a primary understanding of the role that pancreatic cancer patients can play in identifying areas of research that are responsive to their needs and priorities when suitably planned. Importantly it also provides a much greater understanding of the grim realities of the disease for those affected. This work is likely to be of value to anyone planning to work with those with a time limited, challenging condition.

  6. Behaviour Guides and Law. Research Perspectives on the (InFormal and its Currently Shifting Foundations

    Directory of Open Access Journals (Sweden)

    Karin Harrasser / Elisabeth Timm

    2010-08-01

    Full Text Available The juridification of social life in the modern bourgeois world was long understood as a triumph of rationality over particular interests, as the “civilisation” of physical violence. For some time now, this grand narrative of the modern world has been criticized as a specific historical case, as Eurocentric and bourgeois. Additionally, the concept and practice of modern, national sovereign statehood is being challenged in many ways. Individuals are also experiencing an unbounding of their “sovereignty”. The article sums up different disciplines’ research into the fields of behaviour guides and law. In doing so, it sketches out research perspectives intended to transcend the either-or dichotomy of the previous debates (ethics / particular / informal / personal / emotional-cultural vs. law / universal / formal / institutional and envisions new analytical assessments of these two poles.

  7. Classification within the cosmopolitan genus Culex (Diptera: Culicidae): the foundation for molecular systematics and phylogenetic research.

    Science.gov (United States)

    Harbach, Ralph E

    2011-01-01

    The internal classification of the cosmopolitan and medically important genus Culex is thoroughly reviewed and updated to reflect the multitude of taxonomic changes and concepts which have been published since the classification was last compiled by Edwards in 1932. Both formal and informal taxa are included. The classification is intended to aid researchers and students who are interested in analyzing species relationships, making group comparisons and testing phylogenetic hypotheses. The genus includes 768 formally recognized species divided among 26 subgenera. Many of the subgenera are subdivided hierarchically into nested informal groups of morphologically similar species that are believed to represent monophyletic lineages based on morphological similarity. The informal groupings proposed by researchers include Sections, Series, Groups, Lines, Subgroups and Complexes, which are unlikely to be phylogenetically equivalent categories among the various subgenera. Copyright © 2011 Elsevier B.V. All rights reserved.

  8. The expanding field of plant virus ecology: historical foundations, knowledge gaps, and research directions.

    Science.gov (United States)

    Malmstrom, Carolyn M; Melcher, Ulrich; Bosque-Pérez, Nilsa A

    2011-08-01

    Plant viruses are widespread in nature, where they operate in intimate association with their hosts and often with vectors. Most research on plant viruses to the present has focused on agricultural systems (agronomic and horticultural) and viruses that are pathogenic. Consequently, there is a dearth of fundamental information about plant virus dynamics in natural ecosystems and how they might differ from or be influenced by virus interactions in managed systems. Key questions include under what conditions the influence of virus on host fitness is negative, neutral, or positive and the extent to which this relationship is influenced by ecosystem properties. To address these critical knowledge gaps, the expanding field of plant virus ecology seeks to examine (i) the ecological roles of plant-associated viruses and their vectors in managed and unmanaged ecosystems and (ii) the reciprocal influence of ecosystem properties on the distribution and evolution of plant viruses and their vectors. In this work, plant virus ecology draws on the achievements of epidemiology and extends the research focus to new ecological arenas. Here we provide an historical perspective and highlight key issues and emerging research directions. We suggest that there is broad need to (i) integrate consideration of plant viruses into ecological research and theory, in which viruses have generally been overlooked, and (ii) to expand ecological perspectives in virology to include new methods and disciplines in ecology, such as ecosystem ecology. Studies of plant-virus-vector interactions in nature offer both opportunities and challenges that will ultimately produce multi-faceted understanding of the role of viruses in shaping ecological and evolutionary dynamics. Copyright © 2011 Elsevier B.V. All rights reserved.

  9. Promoting research in advanced dementia: early clinical results of the Alzheimer Center Reina Sofía Foundation.

    Science.gov (United States)

    Olazarán, Javier; Agüera-Ortiz, Luis; Osorio, Ricardo S; León-Salas, Beatriz; Dobato, José Luis; Cruz-Orduña, Isabel; González, Belén; Valentí, Meritxell; Gil-Ruiz, Nuria; Frades, Belén; Ramos-García, M I; Martínez-Martín, Pablo

    2012-01-01

    The Alzheimer Center Reina Sofía Foundation (ACRSF) was envisaged to address the complex and multi-disciplinary research and care needs posed by Alzheimer's disease (AD) and other neurodegenerative dementias. Patients may be admitted at ACRSF either as inpatients (i.e., nursing home) or outpatients (i.e., day-care center). The research program includes clinical, social, biochemical, genetic, and magnetic resonance investigations, as well as brain donation. We present the inception of the clinical research protocol for the ACRSF, the early results, and the amendments to the protocol. Foreseen as distinct populations, inpatient and outpatient results are presented separately. Data were collected from 180 patients (153 inpatients, 27 outpatients) (86% AD), with informed consent for participation in the research program of the ACRSF. Most patients (95%) had moderate to severe dementia. Nursing home patients were older, displayed marked gait dysfunction, and were significantly more dependent in the activities of daily living (ADL), compared to the day-care patients (p dementia. New measurements were added for evaluation of cognition, apathy, agitation, depression, ADL, motor function, and QoL. The final assessment is expected to be sensitive to change in all the clinical aspects of advanced degenerative dementia, to promote multidisciplinary and, desirably, inter-center collaborative research and, eventually, to contribute to the improvement of treatment and care for these patients.

  10. Conducting multinational, cross-cultural research in the functional gastrointestinal disorders: issues and recommendations. A Rome Foundation working team report.

    Science.gov (United States)

    Sperber, A D; Gwee, K A; Hungin, A P; Corazziari, E; Fukudo, S; Gerson, C; Ghoshal, U C; Kang, J-Y; Levy, R L; Schmulson, M; Dumitrascu, D; Gerson, M-J; Chen, M; Myung, S-J; Quigley, E M M; Whorwell, P J; Zarzar, K; Whitehead, W E

    2014-11-01

    Cross-cultural, multinational research can advance the field of functional gastrointestinal disorders (FGIDs). Cross-cultural comparative research can make a significant contribution in areas such as epidemiology, genetics, psychosocial modulators, symptom reporting and interpretation, extra-intestinal co-morbidity, diagnosis and treatment, determinants of disease severity, health care utilisation, and health-related quality of life, all issues that can be affected by geographical region, culture, ethnicity and race. To identify methodological challenges for cross-cultural, multinational research, and suggest possible solutions. This report, which summarises the full report of a working team established by the Rome Foundation that is available on the Internet, reflects an effort by an international committee of FGID clinicians and researchers. It is based on comprehensive literature reviews and expert opinion. Cross-cultural, multinational research is important and feasible, but has barriers to successful implementation. This report contains recommendations for future research relating to study design, subject recruitment, availability of appropriate study instruments, translation and validation of study instruments, documenting confounders, statistical analyses and reporting of results. Advances in study design and methodology, as well as cross-cultural research competence, have not matched technological advancements. The development of multinational research networks and cross-cultural research collaboration is still in its early stages. This report is intended to be aspirational rather than prescriptive, so we present recommendations, not guidelines. We aim to raise awareness of these issues and to pose higher standards, but not to discourage investigators from doing what is feasible in any particular setting. © 2014 John Wiley & Sons Ltd.

  11. Grouting for Pile Foundation Improvement

    NARCIS (Netherlands)

    Van der Stoel, A.E.C.

    2001-01-01

    The aim of this research was to examine the use of grouting methods for pile foundation improvement, a generic term that is used here to define both foundation renovation (increasing the bearing capacity of a pile foundation that has insufficient bearing capacity) and foundation protection

  12. World Endometriosis Research Foundation Endometriosis Phenome and biobanking harmonization project: II. Clinical and covariate phenotype data collection in endometriosis research

    DEFF Research Database (Denmark)

    Vitonis, Allison F.; Vincent, Katy; Rahmioglu, Nilufer

    2014-01-01

    ObjectiveTo harmonize the collection of nonsurgical clinical and epidemiologic data relevant to endometriosis research, allowing large-scale collaboration.......ObjectiveTo harmonize the collection of nonsurgical clinical and epidemiologic data relevant to endometriosis research, allowing large-scale collaboration....

  13. World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonisation Project: I. Surgical phenotype data collection in endometriosis research

    DEFF Research Database (Denmark)

    Becker, Christian M.; Laufer, Marc R.; Stratton, Pamela

    2014-01-01

    ObjectiveTo standardize the recording of surgical phenotypic information on endometriosis and related sample collections obtained at laparoscopy, allowing large-scale collaborative research into the condition.......ObjectiveTo standardize the recording of surgical phenotypic information on endometriosis and related sample collections obtained at laparoscopy, allowing large-scale collaborative research into the condition....

  14. Complex Intelligent Systems: Juxtaposition of Foundational Notions and a Research Agenda

    Directory of Open Access Journals (Sweden)

    Petros A.M. Gelepithis

    2001-12-01

    Full Text Available Abstract: The cardinality of the class, C , of complex intelligent systems, i.e., systems of intelligent systems and their resources, is steadily increasing. Such an increase, whether designed, sometimes changes significantly and fundamentally, the structure of C . Recently,the study of members of C and its structure comes under a variety of multidisciplinary headings the most prominent of which include General Systems Theory, Complexity Science, Artificial Life, and Cybernetics. Their common characteristic is the quest for a unified theory of a certain class of systems like a living system or an organisation. So far, the only candidate for a general theory of intelligent systems is Newell's Soar. To my knowledge there is presently no candidate theory of C except Newell's claimed extensibility of Soar. This paper juxtaposes the elements of Newell's conceptual basis with those of an alternative conceptual framework based on the thesis that communication and understanding are the primary processes shaping the structure of C and its members. It is patently obvious that a research agenda for the study of C can be extremely varied and long. The third section of this paper presents a highly selective research agenda that aims to provoke discussion among complexity theory scientists.

  15. Medical research: civil liability and compensation for personal injury--a discussion paper. Ciba Foundation Study Group.

    Science.gov (United States)

    1980-01-01

    The Ciba Foundation Study Group has considered the most appropriate means of compensating participants (or their relatives) for injuries received as a consequence of medical research. The group recognises that injury may occur despite the exercise of the highest degree of skill and care by the investigator and that compensation through an action for negligence is therefore not available. At present injured participants have to rely on ex gratia payments. The group considers this unsatisfactory and recommends the establishment of a centrally operated fund with authority to provide compensation on a no-fault basis. These recommendations do not diminish the rights of the participant to bring an action in the event of negligence on the part of the investigator or an action under the law relating to product liability against the manufacturers of defective equipment or drugs. PMID:7388452

  16. 31 March 2016 - Qatar Foundation Research and Development Executive Vice President H. Al-Ibrahim signing a Cooperation Agreement with CERN Director-General F. Gianotti.

    CERN Multimedia

    Brice, Maximilien

    2016-01-01

    Dr Hamad Al-Ibrahim Executive Vice President, Qatar Foundation Research and Development. Were present: CERN International Relations Unit, Adviser for Qatar P. Fassnacht; CERN Director for Research and Computing E. Elsen; Texas A&M Professor of Physics A. Safonov ; CERN Director for International Relations C. Warakaulle; Professor of Physics, Qatar University I.Al-Qaradawi; Executive Vice President H. Al-Ibrahim; CERN Director-General F. Gianotti; Ambassador Faisal Bin Abdulla Al-Henzab to the UNOG; Director of Research Computing, Texas A&M, Qatar O. Bouhali; Vice Dean, Texas A&M, Qatar E. Massad; Executive Director, Research Coordination & Special Initiatives, Qatar Foundation R&D D. Khoury.

  17. 15th March 2011 - Singapore National Research Foundation Permanent Secretary(National Research and Development)T. M. Kian signing the guest book with Head of International Relations F. Pauss and visiting CMS control centre with Collaboration Spokesperson G. Tonelli.

    CERN Multimedia

    Maximilien Brice

    2011-01-01

    15th March 2011 - Singapore National Research Foundation Permanent Secretary(National Research and Development)T. M. Kian signing the guest book with Head of International Relations F. Pauss and visiting CMS control centre with Collaboration Spokesperson G. Tonelli.

  18. Activities of the National Academy of Sciences in relation to the Radiation Effects Research Foundation

    Energy Technology Data Exchange (ETDEWEB)

    Edington, C.W.

    1992-06-01

    This progress report relates progress in the various research projects evaluating the late health effects, both somatic and genetic, resulting from radiation exposure of the survivors of the atomic bombs at Hiroshima and Nagasaki, Japan. Considerable progress has been made in the collection and utilization of the various epidemiological data bases. These include the Life Span Study, (LSS) cohort, the Adult Health Study (AHS) cohort, the In Utero cohort, the leukemia registry and the F-1 Study population. Important progress has been made in using RERF Tumor and Tissue Registry records for evaluation of cancer incidence and radiation risk estimates for comparison with cancer mortality and risk in the LSS cohort. At the present time, a manuscript on the incidence of solid tumors (1950-1987) is undergoing internal and external review for publication as an RERF Technical report (TR) and for publication in a peer-reviewed scientific journal. In addition, manuscripts are in preparation on (1) a comprehensive report on the incidence of hematological cancers, including analysis of leukemia by cell type (1950-1987), (2) a general description of Tumor Registry operations and (3) a comparison of incidence- and mortality-based estimates of radiation risk in the LSS cohort.

  19. [Research progresses of the completed pediatrics projects funded by National Natural Science Foundation of China from 2002 to 2006].

    Science.gov (United States)

    Xu, Ling; Hao, Jie; Deng, Min; Xu, Yan-ying

    2009-05-01

    To understand the projects completion and research progresses in pediatrics which were funded by the National Natural Science Foundation of China (NSFC), and evaluate the accomplishment objectively and justly. The completion status of projects in pediatrics funded by department of clinical medicine II from 2002 to 2006 was analysed retrospectively, and important research achievement and outstanding development in some projects were reported. During the period between 2002 and 2006, 420 articles were published, and the average was 8.1 papers per project, which included 56 papers that were published in journals indexed by SCI (the average was 1.1 papers per project). The completion of general project was better than that of "the Young Researchers Fund" and small grant project. Ten post-doctors, 102 doctors and 109 masters were trained. Two projects were awarded with the first grade prize and another 2 with the second grade prize at the provincial and ministerial level, 4 items applied for patent and 1 was granted. These completed projects, which were mainly related to 7 of 12 subspecialties in the field of pediatrics, such as the respiratory disease, nephrology, neurology, cardiology, endocrinology, hematology, neonatology, are the major portion of the application projects and subsidized projects funded by NSFC, and achieved great research progresses. During the period between 2002 and 2006, the 52 completed projects in pediatrics showed difference in the distribution and quality of accomplishment among subspecialties and among types of supported projects; there are some gaps between pediatrics and some other clinical basic subspecialties II, this situation released the research status and problems in development of pediatrics in China. The general projects completion was good, and many projects obtained research achievements, which reflect the leading function of NSFC in pediatric research.

  20. Bucket foundations

    DEFF Research Database (Denmark)

    Foglia, Aligi; Ibsen, Lars Bo

    In this report, bearing behaviour and installation of bucket foundations are reviewed. Different methods and standards are compared with the experimental data presented in Foglia and Ibsen (2014a). The most important studies on these topics are suggested. The review is focused on the response...... of monopod bucket foundations supporting offshore wind turbines....

  1. Research of the Interaction of Piles with Different Lengths and the Grillage in the Foundations of High-Rise Buildings

    Science.gov (United States)

    Pidlutskyi, Vasyl; Boyko, Igor; Nosenko, Viktor

    2017-09-01

    The interaction of piles with different lengths and the grillage in the foundations of high-rise buildings is considered. The numerical modeling of the «base - foundation - superstructure» system is performed. The redistribution of the efforts in piles depending on the sizes of a foundation slab and the parameters of piles (length and location) is investigated. Typical zones of a foundation such as central, lateral, and angular ones are separated. The redistribution of efforts between piles and a grillage is revealed.

  2. Research of the Interaction of Piles with Different Lengths and the Grillage in the Foundations of High-Rise Buildings

    Directory of Open Access Journals (Sweden)

    Pidlutskyi Vasyl

    2017-09-01

    Full Text Available The interaction of piles with different lengths and the grillage in the foundations of high-rise buildings is considered. The numerical modeling of the «base - foundation - superstructure» system is performed. The redistribution of the efforts in piles depending on the sizes of a foundation slab and the parameters of piles (length and location is investigated. Typical zones of a foundation such as central, lateral, and angular ones are separated. The redistribution of efforts between piles and a grillage is revealed.

  3. Policy-contribution assessment and field-building analysis of the Robert Wood Johnson Foundation's Active Living Research Program.

    Science.gov (United States)

    Ottoson, Judith M; Green, Lawrence W; Beery, William L; Senter, Sandra K; Cahill, Carol L; Pearson, David C; Greenwald, Howard P; Hamre, Robin; Leviton, Laura

    2009-02-01

    The Robert Wood Johnson Foundation requested this utilization-focused evaluation of its Active Living Research (ALR) program. This evaluation reports on the trajectory of influence of past and future ALR outcomes on field-building and policy contributions as well as on possible users of completed and disseminated ALR products. In 2006 and 2007, key-informant interviews were conducted with 136 representatives of first-line potential users of ALR research products, including state physical activity and nutrition program coordinators, policymakers, scientists, and funders. Literature reviews, bibliometric analyses, and document reviews served to describe the context for ALR's work and the ways it could enhance its utility for field building and policymaking. The contributions of ALR to the emerging transdisciplinary field included leadership in the development of measurement tools, epidemiologic studies, implementation research, the translation of research to practice, and the communication of learned lessons to diverse audiences. ALR's contributions to policy discussions were found across a spectrum of policy-development phases that included describing the problem, raising awareness of alternative strategies for increasing physical activity, convening nontraditional partners, and evaluating policy implementation. Policy-relevant research can make contributions to policymakers' thinking but almost never causes a change by itself. Five years after the original authorization of ALR, there is ample evidence of its recognition as a resource by key players, its field-building influence, and its contributions to policy discussions. All these bear promise for a broader contribution to obesity prevention. Recommendations for increasing ALR's impact on policy and practice are offered.

  4. Molecular ageing in progeroid syndromes: Hutchinson-Gilford progeria syndrome as a model

    Directory of Open Access Journals (Sweden)

    da Nóbrega Raphael

    2009-04-01

    Full Text Available Abstract Hutchinson-Gilford progeria syndrome (HGPS is a rare premature aging disorder that belongs to a group of conditions called laminopathies which affect nuclear lamins. Mutations in two genes, LMNA and ZMPSTE24, have been found in patients with HGPS. The p.G608G LMNA mutation is the most commonly reported mutation. The aim of this work was to compile a comprehensive literature review of the clinical features and genetic mutations and mechanisms of this syndrome as a contribution to health care workers. This review shows the necessity of a more detailed clinical identification of Hutchinson-Gilford progeria syndrome and the need for more studies on the pharmacologic and pharmacogenomic approach to this syndrome.

  5. Academic Anesthesiology Career Development: A Mixed-Methods Evaluation of the Role of Foundation for Anesthesiology Education and Research Funding.

    Science.gov (United States)

    Speck, Rebecca M; Ward, Denham S; Fleisher, Lee A

    2018-01-05

    In 1986, the American Society of Anesthesiologists created the Foundation for Anesthesiology Education and Research (FAER) to fund young anesthesiology investigators toward the goal of helping launch their academic careers. Determining the impact of the FAER grant program has been of importance. This mixed-methods study included quantitative data collection through a Research Electronic Data Capture survey and curriculum vitae (CV) submission and qualitative interviews. CVs were abstracted for education history, faculty appointment(s), first and last author peer-reviewed publications, grant funding, and leadership positions. Survey nonrespondents were sent up to 3 reminders. Interview questions elicited details about the experience of submitting a FAER grant. Quantitative data were summarized descriptively, and qualitative data were analyzed with NVivo. Of 830 eligible participants, 38.3% (N = 318) completed surveys, 170 submitted CVs, and 21 participated in interviews. Roughly 85% held an academic appointment. Funded applicants were more likely than unfunded applicants to apply for National Institutes of Health funding (60% vs 35%, respectively; P value of having multiple mentors. Key mentor attributes mentioned were availability, guidance, reputation, and history of success. This cross-sectional data demonstrated career success in publications, grants, and leadership positions for faculty who apply for a FAER grant. A FAER grant application may be a marker for an anesthesiologist who is interested in pursuing a physician-scientist career.

  6. Scleroderma Research Foundation

    Science.gov (United States)

    ... of an investigational drug for SSc-ILD called nintedanib. Nintedanib is an oral drug that has been approved ... which is a disease similar to SSc-ILD. Nintedanib has not been approved for the treatment of ...

  7. FRAXA Research Foundation

    Science.gov (United States)

    ... a cure for fragile X syndrome, the most common inherited cause of autism. In Their Own Words: Reports from the International ... Fragile X? Fragile X syndrome is the most common inherited cause of autism and intellectual disabilities. It affects 1 in 4000 ...

  8. Cardiovascular Research Foundation

    Science.gov (United States)

    Home About Us The Problem Our Model Leadership Faculty Board of Directors Management Team Advancements Drug-eluting stents TAVR Bioresorbable stents Clinicians and Industry Innovate Skirball Center for Innovation Investigate Clinical ...

  9. American Vitiligo Research Foundation

    Science.gov (United States)

    ... by Kim Kirkland Kim Kirkland, a Maryland based fiction has sparked a new conversation about Vitiligo in a delightful and insightful manner. The book’s main character, Chris, a young boy who has ...

  10. Diabetes Research Institute Foundation

    Science.gov (United States)

    ... Caring for Older People with Diabetes Checking Blood Sugar Diabetes at School Exercise and Diabetes Explaining Diabetes to ... Insulin Therapy Keeping Your Heart Healthy Low Blood Sugar Meal Planning Preventing Diabetes Complications Preventing Type 2 Diabetes Setting Goals Sick ...

  11. Glaucoma Research Foundation

    Science.gov (United States)

    ... born with glaucoma. Read her story » Learn About Glaucoma Glaucoma is a complicated disease in which damage ... Christopher doesn't ever want to go blind » Glaucoma 360 Glaucoma 360 — three days of events uniting ...

  12. Dystonia Medical Research Foundation

    Science.gov (United States)

    ... Fellowship Training Program Dystonia Coalition Dystonia Study Group Global Dystonia Registry About Us Mission & History How Will We Find a Cure? People Newsletters & Press Releases Dystonia Dialogue Financials Contact For 40 years, we have fought ...

  13. Hypoparathyroidism in an Egyptian child with Hutchinson-Gilford progeria syndrome: a case report

    Directory of Open Access Journals (Sweden)

    Kalil Kotb

    2012-01-01

    Full Text Available Abstract Introduction Hutchinson-Gilford progeria syndrome is a rare genetic disorder. It is reported to be present in one in eight million and is characterized by severe growth failure, early loss of hair, lipodystrophy, scleroderma, decreased joint mobility, osteolysis, early atherosclerosis and facial features that resemble those of an aged person. Apart from diabetes mellitus, there are no reported abnormalities of thyroid, parathyroid, pituitary or adrenal function. Here, we report the case of a 10-year-old Egyptian child with Hutchinson-Gilford progeria syndrome and hypoparathyroidism. Case presentation A 10-year-old Egyptian boy was referred to our institution for an evaluation of recurrent attacks of muscle cramps, paresthesia of his fingertips and perioral numbness of two months duration. On examination, we found dilated veins present over his scalp with alopecia and frontal bossing, a beaked nose, thin lips, protruding ears, a high pitched voice with sparse hair over his eyebrows and eyelashes and micrognathia but normal dentition. His eyes appeared prominent and our patient appeared to have poor sexual development. A provisional diagnosis of progeria was made, which was confirmed by molecular genetics study. Chvostek's and Trousseau's signs were positive. He had low total calcium (5.4 mg/dL, low ionized calcium (2.3 mg/dL, raised serum phosphate (7.2 mg/dL, raised alkaline phosphatase (118 U/L and low intact parathyroid hormone (1.2 pg/mL levels. He was started on oral calcium salt and vitamin D; his symptoms improved with the treatment and his serum calcium, urinary calcium and alkaline phosphates level were monitored every three months to ensure adequacy of therapy and to avoid hypercalcemia. Conclusion Routine checking of serum calcium, phosphorus and parathyroid hormone will help in the early detection of hypoparathyrodism among children with progeria.

  14. Progeria syndrome with characteristic deformation of proximal radius observed on CT

    Energy Technology Data Exchange (ETDEWEB)

    Sood, S.; Rao, R.C.K.; Ragav, B.; Berry, M. (All India Inst. of Medical Sciences, New Delhi (India). Dept. of Radio-Diagnosis)

    1991-01-01

    The progeria syndrome (Hutchinson-Gilford) is an uncommon disease. A peculiar shape of the proximal radial metaphyseal region caused by an infolding of the cortex was observed on CT in 2 brothers suffering from this disorder, a feature not previously reported. A brief review of the radiologic literature was undertaken. This new observation needs to be further evaluated as it may provide a clinching diagnostic feature of this disease. (orig.).

  15. Hypoparathyroidism in an Egyptian child with Hutchinson-Gilford progeria syndrome: a case report.

    Science.gov (United States)

    Kalil, Kotb Abbass Metwalley; Fargalley, Hekma Saad

    2012-01-17

    Hutchinson-Gilford progeria syndrome is a rare genetic disorder. It is reported to be present in one in eight million and is characterized by severe growth failure, early loss of hair, lipodystrophy, scleroderma, decreased joint mobility, osteolysis, early atherosclerosis and facial features that resemble those of an aged person. Apart from diabetes mellitus, there are no reported abnormalities of thyroid, parathyroid, pituitary or adrenal function. Here, we report the case of a 10-year-old Egyptian child with Hutchinson-Gilford progeria syndrome and hypoparathyroidism. A 10-year-old Egyptian boy was referred to our institution for an evaluation of recurrent attacks of muscle cramps, paresthesia of his fingertips and perioral numbness of two months duration. On examination, we found dilated veins present over his scalp with alopecia and frontal bossing, a beaked nose, thin lips, protruding ears, a high pitched voice with sparse hair over his eyebrows and eyelashes and micrognathia but normal dentition. His eyes appeared prominent and our patient appeared to have poor sexual development. A provisional diagnosis of progeria was made, which was confirmed by molecular genetics study. Chvostek's and Trousseau's signs were positive. He had low total calcium (5.4 mg/dL), low ionized calcium (2.3 mg/dL), raised serum phosphate (7.2 mg/dL), raised alkaline phosphatase (118 U/L) and low intact parathyroid hormone (1.2 pg/mL) levels. He was started on oral calcium salt and vitamin D; his symptoms improved with the treatment and his serum calcium, urinary calcium and alkaline phosphates level were monitored every three months to ensure adequacy of therapy and to avoid hypercalcemia. Routine checking of serum calcium, phosphorus and parathyroid hormone will help in the early detection of hypoparathyrodism among children with progeria.

  16. Novel LMNA mutations cause an aggressive atypical neonatal progeria without progerin accumulation.

    Science.gov (United States)

    Soria-Valles, Clara; Carrero, Dido; Gabau, Elisabeth; Velasco, Gloria; Quesada, Víctor; Bárcena, Clea; Moens, Marleen; Fieggen, Karen; Möhrcken, Silvia; Owens, Martina; Puente, Diana A; Asensio, Óscar; Loeys, Bart; Pérez, Ana; Benoit, Valerie; Wuyts, Wim; Lévy, Nicolas; Hennekam, Raoul C; De Sandre-Giovannoli, Annachiara; López-Otín, Carlos

    2016-06-22

    Progeroid syndromes are genetic disorders that recapitulate some phenotypes of physiological ageing. Classical progerias, such as Hutchinson-Gilford progeria syndrome (HGPS), are generally caused by mutations in LMNA leading to accumulation of the toxic protein progerin and consequently, to nuclear envelope alterations. In this work, we describe a novel phenotypic feature of the progeria spectrum affecting three unrelated newborns and identify its genetic cause. Patients reported herein present an extremely homogeneous phenotype that somewhat recapitulates those of patients with HGPS and mandibuloacral dysplasia. However, pathological signs appear earlier, are more aggressive and present distinctive features including episodes of severe upper airway obstruction. Exome and Sanger sequencing allowed the identification of heterozygous de novo c.163G>A, p.E55K and c.164A>G, p.E55G mutations in LMNA as the alterations responsible for this disorder. Functional analyses demonstrated that fibroblasts from these patients suffer important dysfunctions in nuclear lamina, which generate profound nuclear envelope abnormalities but without progerin accumulation. These nuclear alterations found in patients' dermal fibroblasts were also induced by ectopic expression of the corresponding site-specific LMNA mutants in control human fibroblasts. Our results demonstrate the causal role of p.E55K and p.E55G lamin A mutations in a disorder which manifests novel phenotypic features of the progeria spectrum characterised by neonatal presentation and aggressive clinical evolution, despite being caused by lamin A/C missense mutations with effective prelamin A processing. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  17. Social sciences research in neglected tropical diseases 3: Investment in social science research in neglected diseases of poverty: a case study of Bill and Melinda Gates Foundation

    Directory of Open Access Journals (Sweden)

    Reidpath Daniel

    2011-01-01

    Full Text Available Abstract Background The level of funding provides a good proxy for the level of commitment or prioritisation given to a particular issue. While the need for research relevant to social, economic, cultural and behavioural aspects of neglected tropical diseases (NTD control has been acknowledged, there is limited data on the level of funding that supports NTD social science research. Method A case study was carried out in which the spending of a major independent funder, the Bill and Melinda Gates Foundation (BMGF - was analysed. A total of 67 projects funded between October 1998 and November 2008 were identified from the BMGF database. With the help of keywords within the titles of 67 grantees, they were categorised as social science or non-social science research based on available definition of social science. A descriptive analysis was conducted. Results Of 67 projects analysed, 26 projects (39% were social science related while 41 projects (61% were basic science or other translational research including drug development. A total of US$ 697 million was spent to fund the projects, of which 35% ((US$ 241 million went to social science research. Although the level of funding for social science research has generally been lower than that for non-social science research over 10 year period, social science research attracted more funding in 2004 and 2008. Conclusion The evidence presented in this case study indicates that funding on NTD social science research compared to basic and translational research is not as low as it is perceived to be. However, as there is the acute need for improved delivery and utilisation of current NTD drugs/technologies, informed by research from social science approaches, funding priorities need to reflect the need to invest significantly more in NTD social science research.

  18. Social sciences research in neglected tropical diseases 3: Investment in social science research in neglected diseases of poverty: a case study of Bill and Melinda Gates Foundation.

    Science.gov (United States)

    Pokhrel, Subhash; Reidpath, Daniel; Allotey, Pascale

    2011-01-06

    The level of funding provides a good proxy for the level of commitment or prioritisation given to a particular issue. While the need for research relevant to social, economic, cultural and behavioural aspects of neglected tropical diseases (NTD) control has been acknowledged, there is limited data on the level of funding that supports NTD social science research. A case study was carried out in which the spending of a major independent funder, the Bill and Melinda Gates Foundation (BMGF) - was analysed. A total of 67 projects funded between October 1998 and November 2008 were identified from the BMGF database. With the help of keywords within the titles of 67 grantees, they were categorised as social science or non-social science research based on available definition of social science. A descriptive analysis was conducted. Of 67 projects analysed, 26 projects (39%) were social science related while 41 projects (61%) were basic science or other translational research including drug development. A total of US$ 697 million was spent to fund the projects, of which 35% ((US$ 241 million) went to social science research. Although the level of funding for social science research has generally been lower than that for non-social science research over 10 year period, social science research attracted more funding in 2004 and 2008. The evidence presented in this case study indicates that funding on NTD social science research compared to basic and translational research is not as low as it is perceived to be. However, as there is the acute need for improved delivery and utilisation of current NTD drugs/technologies, informed by research from social science approaches, funding priorities need to reflect the need to invest significantly more in NTD social science research.

  19. Foundation Structure

    DEFF Research Database (Denmark)

    2009-01-01

    Method of installing a bucket foundation structure comprising one, two, three or more skirts, into soils in a controlled manner. The method comprises two stages: a first stage being a design phase and the second stage being an installation phase. In the first stage, design parameters are determined...... relating to the loads on the finished foundation structure; soil profile on the location; allowable installation tolerances, which parameters are used to estimate the minimum diameter and length of the skirts of the bucket. The bucket size is used to simulate load situations and penetration into foundation...

  20. Model of human aging: Recent findings on Werner’s and Hutchinson-Gilford progeria syndromes

    Directory of Open Access Journals (Sweden)

    Shian-ling Ding

    2008-09-01

    Full Text Available Shian-ling Ding1, Chen-Yang Shen2,3,41Department of Nursing, Kang-Ning Junior College of Medical Care and Management, Taipei, Taiwan; 2Institute of Biomedical Sciences, and 3Life Science Library, Academia Sinica, Taipei, Taiwan; 4Graduate Institute of Environmental Science, China Medical University, Taichong, TaiwanAbstract: The molecular mechanisms involved in human aging are complicated. Two progeria syndromes, Werner’s syndrome (WS and Hutchinson-Gilford progeria syndrome (HGPS, characterized by clinical features mimicking physiological aging at an early age, provide insights into the mechanisms of natural aging. Based on recent findings on WS and HGPS, we suggest a model of human aging. Human aging can be triggered by two main mechanisms, telomere shortening and DNA damage. In telomere-dependent aging, telomere shortening and dysfunction may lead to DNA damage responses which induce cellular senescence. In DNA damage-initiated aging, DNA damage accumulates, along with DNA repair deficiencies, resulting in genomic instability and accelerated cellular senescence. In addition, aging due to both mechanisms (DNA damage and telomere shortening is strongly dependent on p53 status. These two mechanisms can also act cooperatively to increase the overall level of genomic instability, triggering the onset of human aging phenotypes.Keywords: human aging, Hutchinson-Gilford Progeria syndrome, Werner syndrome

  1. Mars Exploration Student Data Teams: Building Foundations and Influencing Students to Pursue STEM Careers through Experiences with Authentic Research

    Science.gov (United States)

    Turney, D.; Grigsby, B.; Murchie, S. L.; Buczkowski, D.; Seelos, K. D.; Nair, H.; McGovern, A.; Morgan, F.; Viviano, C. E.; Goudge, T. A.; Thompson, D.

    2013-12-01

    The Mars Exploration Student Data Teams (MESDT) immerses diverse teams of high school and undergraduate students in an authentic research Science, Technology, Engineering and Mathematics (STEM) based experience and allows students to be direct participants in the scientific process by working with scientists to analyze data sets from NASA's Mars program, specifically from the CRISM instrument. MESDT was created by Arizona State University's Mars Education Program, and is funded through NASA's Compact Reconnaissance Imaging Spectrometer for Mars or CRISM, an instrument onboard the Mars Reconnaissance Orbiter (MRO). Students work with teacher mentors and CRISM team members to analyze data, develop hypotheses, conduct research, submit proposals, critique and revise work. All students begin the program with basic Mars curriculum lessons developed by the MESDT education team. This foundation enables the program to be inclusive of all students. Teachers have reported that populations of students with diverse academic needs and abilities have been successful in this program. The use of technology in the classroom allows the MESDT program to successfully reach a nationwide audience and funding provided by NASA's CRISM instrument allows students to participate free of charge. Recent changes to the program incorporate a partnership with United States Geological Survey (USGS) and a CRISM sponsored competitive scholarship for two teams of students to present their work at the annual USGS Planetary Mappers Meeting. Returning MESDT teachers have attributed an increase in student enrollment and interest to this scholarship opportunity. The 2013 USGS Planetary Mappers Meeting was held in Washington DC which provided an opportunity for the students to meet with their Senators at the US Capitol to explain the science work they had done throughout the year as well as the impact that the program had had on their goals for the future. This opportunity extended to the students by the

  2. ABIM Foundation

    Science.gov (United States)

    ... manner. ABIM Foundation asks that you not post comments that: • Disclose personal health information • Violate the intellectual property rights, confidentiality or privacy of another • Include hate speech directed at race, sex, sexual orientation, national ...

  3. Children's Brain Tumor Foundation

    Science.gov (United States)

    ... 2 Family Donate Volunteer Justin's Hope Fund Children’s Brain Tumor Foundation, A non-profit organization, was founded ... and the long term outlook for children with brain and spinal cord tumors through research, support, education, ...

  4. National Psoriasis Foundation

    Science.gov (United States)

    ... 723-9166 | Submit a Question | Learn More National Psoriasis Foundation provides you with the help you need to best manage your psoriasis or psoriatic arthritis, while promoting research to find ...

  5. National Pancreas Foundation

    Science.gov (United States)

    ... More Read More Success Stories More Success Stories Facebook Twitter Youtube rss feed Instagram About Us Patient Information Research State Chapters Take Action Donate E-News Sign-Up The National Pancreas Foundation 3 ...

  6. Theoretical Foundations of Research Focused on HIV Prevention Among Substance-Involved Women: A Review of Observational and Intervention Studies.

    Science.gov (United States)

    Auerbach, Judith D; Smith, Laramie R

    2015-06-01

    Although substance use continues to be a significant component of HIV risk among women worldwide, to date, relatively little attention has been paid in research, services, or policy to substance-involved women (SIW). HIV acquisition for SIW stems from transmission risks directly related to substance use and risks associated with sexual activity in which power to negotiate risk and safety are influenced by dynamics of male partnerships, sex work, and criminalization (of both drug use and sex work), among other factors. As such, HIV risk for SIW resides as much in the environment—physical, social, cultural, economic, and political—in which drug use occurs as it does from transmission-related behaviors of individual women. To reduce HIV infections among SIW, it is important to specify the interaction of individual- and environmental-level factors, including, but not limited to those related to women's own substance use, that can and ought to be changed. This involves theorizing about the interplay of gender, substance use, and HIV risk, and incorporating that theoretical understanding into intervention design and evaluation. A review of the published literature focused on HIV prevention among SIW revealed a general lack of theoretical and conceptual foundation specific to the gender-related and environmental drivers of HIV in this population. Greater theoretical linkages to intersectionality and syndemic approaches are recommended to better identify and target relevant mechanisms by which the interplay of gender dynamics and substance use potentiate the likelihood of HIV acquisition and transmission among SIW.

  7. The prospective development of Climate and Environmental Research Laboratory of AARI, Roshydromet, after gaining the grant of Russian Science Foundation

    Directory of Open Access Journals (Sweden)

    V. Ya. Lipenkov

    2014-01-01

    Full Text Available In November 2010 a new research unit was inaugurated in Arctic and Antarctic Research Institute (St. Petersburg – Climate and Environmental Research Laboratory (CERL – that became the first lab in Russia dedicated to the complex studies of ice cores, paleoclimate and subglacial environments in Antarctica. The total investments to construct the laboratory were 28.8 million rubles, provided by Roshydromet and AARI in frames of implementing the program of International Polar Year. The total area of the laboratory is about 300 m² that includes mass-spectrometric and gas analyses labs, cold chambers and utility rooms. The CERL’s equipment comprises laser stable water isotope analyzer Picarro L2120-i, IR mass-spectrometer Delta V Plus, system of gas extraction from ice, facilities for ice petrographic observations, for ice core treatment and storage. Before 2014 CERL was the head unit in the project “Complex studies of Lake Vostok and glaciological investigations of Antarctica” of the sub-program “Antarctica” of the FTP “World Ocean”. Now CERL is the leading organization in International Associated Laboratory “Ice archives of climatic and environmental data” that combines 4 French and 5 Russian scientific research groups. In 2014 the specialists of CERL won a grant of Russian Science Foundation for fundamental scientific works implemented by operating research laboratories. Project 14-27-00030 “Evolution of climate, glaciation and subglacial environments of Antarctica from the deep ice core and Lake Vostok water sample studies” (2014–2016 is intended to refine the reconstruction of Antarctic climate history over the past 400,000 years using the newly developed geochemical methods of ice core studies. Another goal is to develop the approaches to study the hydrological parameters of subglacial Lake Vostok using the samples of lake ice and water. The funding to be received through the grant (58.5 million rubles will be mainly

  8. [Evolution and scientific impact of research grants from the spanish society of cardiology and spanish heart foundation (2000-2006)].

    Science.gov (United States)

    Aleixandre Benavent, Rafael; Alonso Arroyo, Adolfo; Anguita Sánchez, Manuel; Bolaños Pizarro, Máxima; Heras, Magda; González Alcalde, Gregorio; Macaya Miguel, Carlos; Navarro Molina, Carolina; Castelló Cogollos, Lourdes; Valderrama Zurián, Juan Carlos; Chorro Gascó, Francisco Javier; Bertomeu Martínez, Vicente; Salvador Taboada, María Jesús; Plaza Celemín, Leandro; Pérez-Villacastín, Julián; Cequier Fillat, Angel; Varela Román, Alfonso; Laraudogoitia Zaldumbide, Eva; Morell Cabedo, Salvador

    2011-10-01

    The Sociedad Española de Cardiología (Spanish Society of Cardiology) every year awards grants to finance research in the field of cardiovascular diseases. The aim of this study is to identify the impact of these investments during the period 2000-2006 from the subsequently published articles in scientific journals. Using the identifying data of each project as search terms, all articles that resulted from these grants were located in the Spanish Índice Médico Español and Índice Bibliográfico Español en Ciencias de la Salud databases, and in Science Citation Index-Expanded and Scopus. Descriptive statistical analysis of these articles included type of grant, number and amount awarded per year, and the recipient's sex and institutional affiliation. The Sociedad Española de Cardiología awarded €3,270,877 to 207 recipients, an average annual total of €467,268. We identified 231 publications that resulted from 123 (59.42%) of these grants. The average number of articles per grant awarded was 1.12, and 1.9 when taking into account only the awards that led to publication. During the period 2000 to 2006, the Sociedad Española de Cardiología/ Fundación Española del Corazón (Spanish Heart Foundation) provided about €500,000 per year to fund research grants, thereby contributing to the fight against cardiovascular diseases. Almost 60% of grants have led to publications, 73% of which were published in international journals, and 91.34% in national or international journals with an impact factor in the Journal Citation Reports. Copyright © 2011 Sociedad Española de Cardiología. Published by Elsevier Espana. All rights reserved.

  9. Development of the Diary for Irritable Bowel Syndrome Symptoms to Assess Treatment Benefit in Clinical Trials: Foundational Qualitative Research.

    Science.gov (United States)

    Fehnel, Sheri E; Ervin, Claire M; Carson, Robyn T; Rigoni, Gianna; Lackner, Jeffrey M; Coons, Stephen Joel

    2017-04-01

    Irritable bowel syndrome (IBS) is a chronic gastrointestinal disorder characterized by abdominal pain and alterations in bowel habits. Three subtypes are defined on the basis of stool patterns: diarrhea-predominant IBS, constipation-predominant IBS, and alternating or mixed IBS. To develop patient-reported outcome measures for qualification by the Food and Drug Administration to support product approvals and labeling in IBS; the article focuses on the qualitative research that provided the foundation for the new measures. Forty-nine concept elicitation and 42 cognitive debriefing interviews were conducted with subjects meeting Rome III criteria; additional criteria were imposed to yield a sample representative of the target patient population. Although incomplete bowel movements, abnormal stool frequency and consistency, and abdominal pain, discomfort, and bloating were reported most frequently across concept elicitation interviews, the relative importance of specific symptoms varied by subtype. Among their five symptoms most important to treat, diarrhea-predominant and alternating or mixed IBS subjects frequently identified urgency, loose/watery stools, abdominal pain, and cramping, whereas constipation-predominant IBS subjects commonly included infrequent and incomplete bowel movements, bloating, and abdominal pain. The cognitive debriefing interviews facilitated refinement of each item set, supported minor modifications following translatability assessment, and suggested improvements to the electronic interface. Furthermore, subjects reported that every item was relevant and no concepts of importance were missing. Results support the content validity of the IBS patient-reported outcome measures. A pilot study was recently initiated to inform item reduction, develop scoring algorithms, and provide preliminary psychometric information. Comprehensive psychometric evaluation and responder definition development will follow. Copyright © 2017 International Society

  10. 'The industry must be inconspicuous': Japan Tobacco's corruption of science and health policy via the Smoking Research Foundation.

    Science.gov (United States)

    Iida, Kaori; Proctor, Robert N

    2018-02-04

    To investigate how and why Japan Tobacco, Inc. (JT) in 1986 established the Smoking Research Foundation (SRF), a research-funding institution, and to explore the extent to which SRF has influenced science and health policy in Japan. We analysed documents in the Truth Tobacco Industry Documents archive, along with recent Japanese litigation documents and published documents. JT's effort to combat effective tobacco control was strengthened in the mid-1980s, following privatisation of the company. While remaining under the protection of Japan's Ministry of Finance, the semiprivatised company lost its 'access to politicos', opening up a perceived need for collaboration with global cigarette makers. One solution, arrived at through clandestine planning with American companies, was to establish a third-party organisation, SRF, with the hope of capturing scientific and medical authority for the industry. Guarded by powerful people in government and academia, SRF was launched with the covert goal of influencing tobacco policy both inside and outside Japan. Scholars funded by SRF have participated in international conferences, national advisory committees and tobacco litigation, in most instances helping the industry to maintain a favourable climate for the continued sale of cigarettes. Contrary to industry claims, SRF was never meant to be independent or neutral. With active support from foreign cigarette manufacturers, SRF represents the expansion into Asia of the denialist campaign that began in the USA in 1953. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  11. Applied Foundations

    DEFF Research Database (Denmark)

    Kohlenbach, Ulrich

    2002-01-01

    A central theme in the foundations of mathematics, dating back to D. Hilbert, can be paraphrased by the following question "How is it that abstract methods (`ideal elements´) can be used to prove `real´ statements e.g. about the natural numbers and is this use necessary in principle?"......A central theme in the foundations of mathematics, dating back to D. Hilbert, can be paraphrased by the following question "How is it that abstract methods (`ideal elements´) can be used to prove `real´ statements e.g. about the natural numbers and is this use necessary in principle?"...

  12. Progeria caused by a rare LMNA mutation p.S143F associated with mild myopathy and atrial fibrillation.

    Science.gov (United States)

    Madej-Pilarczyk, Agnieszka; Kmieć, Tomasz; Fidziańska, Anna; Rekawek, Joanna; Niebrój-Dobosz, Irena; Turska-Kmieć, Anna; Nestorowicz, Klaudia; Jóźwiak, Sergiusz; Hausmanowa-Petrusewicz, Irena

    2008-09-01

    We present a 6-year-old girl with premature aging associated with mild myopathy, displaying muscle weakness, joint contractures and hyporeflexia. Genetic analysis revealed rare heterozygous point mutation in lamin A/C gene, g.428C>T. Cardiological evaluation showed atrial fibrillation, but we did not find signs of coronary heart disease, which is life-threatening cardiovascular complication in progeria. Electron microscopy of the muscle revealed abnormalities in nuclear architecture, i.e. blebbing, thick lamina and peripheral distribution of heterochromatin. As some diagnostic criteria characteristic for classic progeria are not fulfilled, this case could be regarded as atypical progeria associated with myopathy and atrial fibrillation. To our knowledge, this is the second case of such association described in the literature.

  13. Foundations of measurement

    CERN Document Server

    Suppes, Patrick

    1989-01-01

    Foundations of Measurement offers the most coherently organized treatment of the topics and issues central to measurement. Much of the research involved has been scattered over several decades and a multitude of journals--available in many instances only to specialties. With the publication of Volumes two and three of this important work, Foundations of Measurement is the most comprehensive presentation in the area of measurement.

  14. Fundamentos, modelos conceituais, aplicações e pesquisa da terapia cognitiva Cognitive therapy: foundations, conceptual models, applications and research

    Directory of Open Access Journals (Sweden)

    Paulo Knapp

    2008-10-01

    Full Text Available OBJETIVO: Há um interesse crescente no modelo cognitivo de psicoterapia estimulado por grande número de resultados de pesquisa, demonstrando sua eficácia em uma série de transtornos psiquiátricos e distúrbios médicos. Este artigo de revisão objetiva dar um panorama dos fundamentos históricos e filosóficos das abordagens cognitivo-comportamentais contemporâneas, e apontar similaridades e diferenças entre elas. O modelo cognitivo, conforme delineado por Aaron Beck, e alguns dos procedimentos e técnicas cognitivas e comportamentais utilizados em transtornos emocionais serão apresentados. Ao final, resultados de pesquisas e metanálises em relação à eficácia das terapias cognitivas e cognitivo-comportamentais em vários transtornos psiquiátricos e distúrbios médicos serão relatados brevemente. MÉTODO: Por meio da revisão de artigos e livros-texto, principalmente dos trabalhos de Aaron Beck dos quais foi extraída a presente revisão, foram descritas as origens e os fundamentos das abordagens cognitivo-comportamentais no tratamento dos transtornos psiquiátricos e médicos. Através de buscas no Medline de ensaios clínicos randomizados e metanálises, foram apontadas as evidências de eficácia dessa modalidade de tratamento psicoterápico. RESULTADOS E CONCLUSÕES: As terapias cognitivo-comportamentais em geral, e a terapia cognitiva beckiana em especial, apresentam um fundamento teórico e um conjunto de técnicas cuja eficácia baseada em evidências foi demonstrada no tratamento de diversos quadros mentais e físicos.OBJECTIVE: There is growing interest in the cognitive model of psychotherapy stimulated by an extensive body of research findings demonstrating its effectiveness for a varied set of psychiatric disorders and medical conditions. This review article aims to give an overview of the historical and philosophical background to contemporary cognitive and cognitive-behavioral approaches to psychotherapy, pointing out

  15. Simultaneous Shoulder and Hip Dislocation in a 12-Year-Old Girl with Hutchinson-Gilford Progeria Syndrome

    Directory of Open Access Journals (Sweden)

    Shirin Mardookhpour

    2012-06-01

    Full Text Available Hutchinson-Gilford progeria syndrome (HGPS is a rare premature ageing disorder that is characterized by accelerated degenerative changes of the cutaneous, musculoskeletal and cardiovascular systems. Mean age at diagnosis is 2.9 years and generally leading to death at approximately 13 years of age due to myocardial infarction or stroke. Orthopedic manifestations of HGPS are multiple and shoulder dislocation is a rare skeletal trauma in progeria syndrome. Our patient had simultaneous shoulder and hip dislocation associated with a low energy trauma. This subject has not been reported. Treatment accomplished as close reduction under general anesthesia and immobilization.

  16. Radiological Diagnosis of a Rare Premature Aging Genetic Disorder: Progeria (Hutchinson-Gilford Syndrome

    Directory of Open Access Journals (Sweden)

    Haji Mohammed Nazir

    2017-01-01

    Full Text Available Hutchinson-Gilford Progeria Syndrome (HGPS is a rare disease with a combination of short stature, bone abnormalities, premature ageing, and skin changes. Though the physical appearance of these patients is characteristic, there is little emphasis on the characteristic radiological features. In this paper, we report a 16-year-old boy with clinical and radiological features of this rare genetic disorder. He had a characteristic facial appearance with a large head, large eyes, thin nose with beaked tip, small chin, protruding ears, prominent scalp veins, and absence of hair.

  17. Computational Exploration for Lead Compounds That Can Reverse the Nuclear Morphology in Progeria

    Directory of Open Access Journals (Sweden)

    Shailima Rampogu

    2017-01-01

    Full Text Available Progeria is a rare genetic disorder characterized by premature aging that eventually leads to death and is noticed globally. Despite alarming conditions, this disease lacks effective medications; however, the farnesyltransferase inhibitors (FTIs are a hope in the dark. Therefore, the objective of the present article is to identify new compounds from the databases employing pharmacophore based virtual screening. Utilizing nine training set compounds along with lonafarnib, a common feature pharmacophore was constructed consisting of four features. The validated Hypo1 was subsequently allowed to screen Maybridge, Chembridge, and Asinex databases to retrieve the novel lead candidates, which were then subjected to Lipinski’s rule of 5 and ADMET for drug-like assessment. The obtained 3,372 compounds were forwarded to docking simulations and were manually examined for the key interactions with the crucial residues. Two compounds that have demonstrated a higher dock score than the reference compounds and showed interactions with the crucial residues were subjected to MD simulations and binding free energy calculations to assess the stability of docked conformation and to investigate the binding interactions in detail. Furthermore, this study suggests that the Hits may be more effective against progeria and further the DFT studies were executed to understand their orbital energies.

  18. Autophagic degradation of farnesylated prelamin A as a therapeutic approach to lamin-linked progeria

    Directory of Open Access Journals (Sweden)

    V. Cenni

    2011-10-01

    Full Text Available Farnesylated prelamin A is a processing intermediate produced in the lamin A maturation pathway. Accumulation of a truncated farnesylated prelamin A form, called progerin, is a hallmark of the severe premature ageing syndrome, Hutchinson-Gilford progeria. Progerin elicits toxic effects in cells, leading to chromatin damage and cellular senescence and ultimately causes skin and endothelial defects, bone resorption, lipodystrophy and accelerated ageing. Knowledge of the mechanism underlying prelamin A turnover is critical for the development of clinically effective protein inhibitors that can avoid accumulation to toxic levels without impairing lamin A/C expression, which is essential for normal biological functions. Little is known about specific molecules that may target farnesylated prelamin A to elicit protein degradation. Here, we report the discovery of rapamycin as a novel inhibitor of progerin, which dramatically and selectively decreases protein levels through a mechanism involving autophagic degradation. Rapamycin treatment of progeria cells lowers progerin, as well as wild-type prelamin A levels, and rescues the chromatin phenotype of cultured fibroblasts, including histone methylation status and BAF and LAP2alpha distribution patterns. Importantly, rapamycin treatment does not affect lamin C protein levels, but increases the relative expression of the prelamin A endoprotease ZMPSTE24. Thus, rapamycin, an antibiotic belonging to the class of macrolides, previously found to increase longevity in mouse models, can serve as a therapeutic tool, to eliminate progerin, avoid farnesylated prelamin A accumulation, and restore chromatin dynamics in progeroid laminopathies.

  19. Bilateral stenosis of carotid siphon in Hutchinson-Gilford progeria syndrome.

    Science.gov (United States)

    Narazaki, Ryo; Makimura, Mika; Sanefuji, Masafumi; Fukamachi, Shigeru; Akiyoshi, Hidetaka; So, Hidenori; Yamamura, Kenichiro; Doisaki, Sayoko; Kojima, Seiji; Ihara, Kenji; Hara, Toshiro; Ohga, Shouichi

    2013-08-01

    Hutchinson-Gilford progeria syndrome (HGPS) is a rare premature aging disease, caused by a de novo mutation of lamin-A gene, LMNA G608G. Accumulation of abnormal lamin-A (progerin) compromises nuclear membrane integrity and results in the accelerated senescence. Affected patients show a typical feature of birdlike face, alopecia, sclerotic skin, loss of subcutaneous fat, and short stature with advancing years. Neonatal scleroderma is the first presentation, although early diagnosis is challenging. The leading cause of death is cardio-/cerebro-vascular accidents associated with atherosclerosis. However, not all findings may recapitulate the aging process. We herein report a 9-year-old Japanese male with HGPS who developed cerebral infarction. The genetic study of peripheral blood-derived DNA determined a heterozygous c.1824C>T mutation, p.G608G. Telomere length of lymphocytes was normal. Bilateral stenosis of carotid siphons was prominent, while systemic arteriosclerosis was unremarkable assessed by the ankle-brachial index, carotid ultrasound imaging and funduscopic study. HGPS patients have marked loss and functional defects in vascular smooth muscle cells, leading to the vulnerability to circulatory stress. Symmetrical stenosis of siphons might occur as a distinctive cerebral vasculopathy of HGPS, rather than simple vascular senescence. Peripheral blood study on LMNA G608G and telomere length could screen progerias in infancy for early therapeutic intervention. Copyright © 2012 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.

  20. Oral and Maxillofacial Surgery Foundation Research and Fellowship Awards: A 26-Year Review at Massachusetts General Hospital and Harvard School of Dental Medicine.

    Science.gov (United States)

    Inverso, Gino; Chuang, Sung-Kiang; Kaban, Leonard B

    2016-02-01

    The purpose of this study was to review outcomes of the Oral and Maxillofacial Surgery (OMS) Foundation's funding awards to members of the OMS department at Massachusetts General Hospital (MGH) in terms of projects completed, abstracts presented, peer-reviewed publications, and career trajectories of recipients. Data were collected from MGH and OMS Foundation records and interviews with award recipients. Primary outcome variables included 1) number of awards and award types, 2) funding amount, 3) project completion, 4) number of presented abstracts, 5) conversion from abstracts to publications, 6) number of peer-reviewed publications, 7) career trajectories of awardees, and 8) additional extramural funding. Eleven Student Research Training Awards provided $135,000 for 39 projects conducted by 37 students. Of these, 34 (87.2%) were completed. There were 30 student abstracts presented, 21 peer-reviewed publications, and a publication conversion rate of 58.8%. Faculty research awards comprised $1,510,970 for 22 research projects by 12 faculty members and two research fellows. Of the 22 funded projects, 21 (95.5%) were completed. There were 110 faculty and research fellow abstracts presented and 113 peer-reviewed publications, for a publication conversion rate of 93.8%. In the student group, 17 of 37 (45.9%) are enrolled in or are applying for OMS residencies. Of the 10 students who have completed OMS training, 3 (30%) are in full-time academic positions. Of the 12 faculty recipients, 9 (75%) remain in OMS academic practice. During this time period, the department received $9.9 million of extramural foundation or National Institutes of Health funding directly or indirectly related to the OMS Foundation grants. The results of this study indicate that 90.2% of projects funded by the OMS Foundation have been completed. Most projects resulted in abstracts and publications in peer-reviewed journals. These grants encouraged students to pursue OMS careers and aided OMS

  1. The origins of the research on the foundations of quantum mechanics (and other critical activities) in Italy during the 1970s

    Science.gov (United States)

    Baracca, Angelo; Bergia, Silvio; Del Santo, Flavio

    2017-02-01

    We present a reconstruction of the studies on the Foundations of Quantum Mechanics carried out in Italy at the turn of the 1960s. Actually, they preceded the revival of the interest of the American physicists towards the foundations of quantum mechanics around mid-1970s, recently reconstructed by David Kaiser in a book of 2011. An element common to both cases is the role played by the young generation, even though the respective motivations were quite different. In the US they reacted to research cuts after the war in Vietnam, and were inspired by the New Age mood. In Italy the dissatisfaction of the young generations was rooted in the student protests of 1968 and the subsequent labour and social fights, which challenged the role of scientists. The young generations of physicists searched for new scientific approaches and challenged their own scientific knowledge and role. The criticism to the foundations of quantum mechanics and the perspectives of submitting them to experimental tests were perceived as an innovative research field and this attitude was directly linked to the search for an innovative and radical approach in the history of science. All these initiatives gave rise to booming activity throughout the 1970s, contributing to influence the scientific attitude and the teaching approach.

  2. But…What about My Epistemological Foundations?

    Science.gov (United States)

    Curin, Raquel Isabel Barrera

    2015-01-01

    At one time or another, all researchers in mathematics education must face the rather complex question of their epistemological foundations. Discussing epistemological foundations naturally leads to a conversation about theories. Theories and epistemological foundations work in a circular fashion: theories can have epistemological foundations and…

  3. CARES Foundation

    Science.gov (United States)

    ... html CLICK HERE for article from USA Today Magazine HELP US MAKE A DIFFERENCE IN THE LIVES ... as “Congenital Adrenal Hyperplasia Research Educ & Support Found, Inc aka CARES Foundation” Support Our Mission Research, education ...

  4. Hutchinson-Gilford progeria syndrome with severe calcific aortic valve stenosis

    Directory of Open Access Journals (Sweden)

    Natesh B Hanumanthappa

    2011-01-01

    Full Text Available Hutchinson-Gilford progeria syndrome (HGPS is a rare premature aging syndrome that results from mutation in the Laminin A gene. This case report of a 12-year-old girl with HGPS is presented for the rarity of the syndrome and the classical clinical features that were observed in the patient. All patients with this condition should undergo early and periodic evaluation for cardiovascular diseases. However, the prognosis is poor and management is mainly conservative. There is no proven therapy available. Mortality in this uniformly fatal condition is primarily due to myocardial infarction, strokes or congestive cardiac failure between ages 7 and 21 years due to the rapidly progressive arteriosclerosis involving the large vessels.

  5. A 36 years old woman with Hutchinson-Gilford Progeria Syndrome: a case report

    Directory of Open Access Journals (Sweden)

    Akrami S M

    2007-10-01

    Full Text Available Background: Hutchinson-Gilford Progeria Syndrome (HGPS is a very rare genetic disorder with a frequency of 1 in 8 million live births. It is characterised by premature aging phenotype. The median age at death is 13.4 years. It is an autosomal dominat disease due to a de novo point mutation in the Lamin A gene exon 11 in the majority of cases. More than 100 cases have been reported world wide."nCase report: We describe here an exceptionally long-lived patient with HGPS, who is alive at age 36. She was referred by a cardiologist to our endocrinology clinic to be worked up for presence of a metabolic or genetic disorder before a heart surgery."nResults: Having more attention of clinicians about very rare diseases and referring the patients to geneticist are the main goals of this case report as well as describing the disease.

  6. Hip pathology in Hutchinson-Gilford progeria syndrome: a report of two children.

    Science.gov (United States)

    Akhbari, Pouya; Jha, Shilpa; James, Kyle D; Hinves, Barry L; Buchanan, Jamie A F

    2012-11-01

    Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disorder. The estimated incidence is one in 4 million births. Orthopaedic manifestations include abnormality of the hips occurring early in the disease process. Severe coxa valga can be apparent by the age of 2 years. We report two cases of HGPS, one in a 7-year-old girl with avascular necrosis of the left hip and the second in a 13-year-old girl with recurrent traumatic hip dislocations. We demonstrate the pathoanatomical changes in the hip with HGPS using a combination of imaging modalities including radiographic, computed tomographic and MRI scans. These include coxa magna, coxa valga and acetabular dysplasia. We also comment on how these would affect the surgical management of this high-risk group of patients. © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins.

  7. Characteristic Behavior of Bucket Foundations

    DEFF Research Database (Denmark)

    Barari, Amin

    the design of offshore wind turbine foundations. The work was divided into two main research efforts: geotechnical engineering experiments to gain insight into the behavior of offshore bucket foundations, and development of methods to improve the study of infiltration into unsaturated soils, an important...

  8. [Analysis of hot spots and trend of molecular pharmacognosy research based on project supported by National Natural Science Foundation of 1995-2014].

    Science.gov (United States)

    Wang, Jun-Wen; Liu, Yang; Tong, Yuan-Yuan; Yang, Ce; Li, Hai-Yan

    2016-05-01

    This study collected 1995-2014 molecular pharmacognosy study, a total of 595 items, funded by Natural Science Foundation of China (NSFC). TDA and Excel software were used to analyze the data of the projects about general situation, hot spots of research with rank analytic and correlation analytic methods. Supported by NSFC molecular pharmacognosy projects and funding a gradual increase in the number of, the proportion of funds for pharmaceutical research funding tends to be stable; mainly supported by molecular biology methods of genuine medicinal materials, secondary metabolism and Germplasm Resources Research; hot drugs including Radix Salviae Miltiorrhizae, Radix Rehmanniae, Cordyceps sinensis, hot contents including tanshinone biosynthesis, Rehmannia glutinosa continuous cropping obstacle. Copyright© by the Chinese Pharmaceutical Association.

  9. Bucket Foundation Response Under Various Displacement Rates

    DEFF Research Database (Denmark)

    Vaitkunaite, Evelina; Nielsen, Benjaminn Nordahl; Ibsen, Lars Bo

    2016-01-01

    The present testing program aims at showing the pore pressure response around a bucket foundation skirt as well as the load and displacement change due to ten different displacement rates. Research findings are useful for a numerical model calibration focusing on the design of the upwind foundation...... in a multi-bucket foundation system. The foundation model is at a scale of approximately 1:20 prototype foundation size. The tests are performed in a pressure tank with the foundation model installed in dense sand. Based on the data, the conclusion is that the bucket foundation design in a storm case should...

  10. Aspen Handbook on the Media, 1975-76 Edition. Research, Publications, Organizations, Foundation Support, Government Review, International Communication Agencies.

    Science.gov (United States)

    Rivers, William L., Ed.; Slater, William T., Ed.

    The second edition of this guide to media organization and media research doubles previous listings and includes new sections on international organizations, law school programs dealing with the media, and an expanded section on government activities. Basic listings include universities and other institutions conducting major media research,…

  11. The Convention on the Rights of Persons with Disabilities: a foundation for ethical disability and health research in developing countries.

    Science.gov (United States)

    Durham, Jo; Brolan, Claire E; Mukandi, Bryan

    2014-11-01

    The United Nations Convention on the Rights of Persons with Disabilities (CRPD) has foregrounded disability as a human rights and equity issue, elevating it to a priority global research area. Academics from Western universities are likely to play an increasing role in disability health research in developing countries. In such contexts, there is a need to bridge the gap between procedural ethics and the realities of disability research in cross-cultural contexts. We provide guidance on engaging in ethical disability health research that intersects with and upholds the CRPD. We highlight challenges and tensions in doing so, underscoring the need to be sensitive to the sociocultural and political context of disability that determines how ethical research should proceed. We conclude with 5 recommendations.

  12. Cooperation Agreement between the European Organization for Nuclear Research (CERN) and The Qatar Foundation for Education, Science and Community Development concerning Scientific and Technical Co-operation in High Energy Physics

    CERN Document Server

    2016-01-01

    Cooperation Agreement between the European Organization for Nuclear Research (CERN) and The Qatar Foundation for Education, Science and Community Development concerning Scientific and Technical Co-operation in High Energy Physics

  13. Transient monoparesis following blade plate removal in a Hutchinson-Gilford progeria syndrome patient. A case report

    OpenAIRE

    Yandow, Suzanne M.; Rimoin, David L.; Grace, Aimee M.; Fillman, Ramona R.; Raney, Ellen M.

    2009-01-01

    Treating patients with Hutchinson-Gilford progeria syndrome (HGPS) are based on the abnormalities of accelerated aging that affect the healing processes, combined with a fragile cardiovascular status. A classic HGPS case is presented, of Korean ancestry, who was treated for severe coxa valga with bilateral varus osteotomies using blade plate fixation. Complications over the blade plate area required removal of the hardware, after which the patient displayed left-sided hypertonicity--determine...

  14. [Overview of research projects funding in traditional Chinese medicine oncology field supported by National Natural Science Foundation of China].

    Science.gov (United States)

    Tang, Dong-Xin; Chen, Lian-Yu; Guo, Shu-Zhen; Han, Li-Wei; Zhang, Feng-Zhu

    2017-05-01

    In this paper, the funding situation of traditional Chinese medicine oncology research projects supported by National Natural Science Fund from 1986-2016 was reviewed. The characteristics of funded projects were summarized from funding amount, funding expenses, funding category, and the main research contents of projects, etc. At the same time, the main problems in the projects were analyzed in this paper, in order to provide reference for the relevant fund applicants. Copyright© by the Chinese Pharmaceutical Association.

  15. Mathematical foundations of thermodynamics

    CERN Document Server

    Giles, R; Stark, M; Ulam, S

    2013-01-01

    Mathematical Foundations of Thermodynamics details the core concepts of the mathematical principles employed in thermodynamics. The book discusses the topics in a way that physical meanings are assigned to the theoretical terms. The coverage of the text includes the mechanical systems and adiabatic processes; topological considerations; and equilibrium states and potentials. The book also covers Galilean thermodynamics; symmetry in thermodynamics; and special relativistic thermodynamics. The book will be of great interest to practitioners and researchers of disciplines that deal with thermodyn

  16. ["Maintaining a Common Culture"--the German Research Foundation and the Austrian-German scientific aid in the interbellum].

    Science.gov (United States)

    Fengler, Silke; Luxbacher, Günther

    2011-12-01

    After the end of the Great War, private as well as public research funding in Austria was anaemic and slow to develop. Whereas the German state-funded Deutsche Forschungsgemeinschaft (DFG) was established as early as 1920, first steps in that direction were only taken in Austria in the late 1920s. In 1929, the Osterreichisch-deutsche Wissenschaftshilfe (ODW) was founded under the auspices of the Austrian Academy of Sciences and the DFG. Although prima facie on an equal footing, the new research funding organisation was in fact highly dependent on its German cooperation partner. The article explores for the first time ODW's position within the German and Austrian science and foreign policies, which aimed to promote the idea of unification of both states within the German Reich. A quantitative analysis of the subsidies policy in the first five years of existence shows that the ODW gave financial aid primarily to conservative research fields, affecting the intellectual balance of power in the First Austrian Republic. Policy continuities and discontinuities of the organisation in the course of the national-socialist rise to power in Germany after 1933 are examined in the second part of the article. The article thus both increases our knowledge about the most important German research funding organisation DFG, and identifies some of the fundamental structural features of Austrian science policy in the interwar years.

  17. Proceedings of the Workshop on Design, Construction, and Research for Ribbed Mat Foundations Held in Vicksburg, Mississippi on August 25-27, 1987

    Science.gov (United States)

    1988-03-01

    154 VIH Inspection of Shallow Foundations . . . . . . . . 156 VII Inspection of Deep Foundations . . . . . . . . . 156 VII SAFETY...SHAPE OF MAT MINERALOGY BELOW-SLAB UTILITIES STIFFNESS OF CLAY CONTENT MAT *DEPTH OF ACTIVE SITE PREP . ZONE METHOD OF .CHANGE IN SOIL BACKFILL...MOISTURE CONTENT LOAD MAGNITUDE *EXTENT OF CLAY FRACTURING LOAD LOCATION FOUNDATION PREP . LOAD TYPE PRE-CONSTRUCTION METHOD OF VEGETATION REINFORCEMENT

  18. Research on the Horizontal Displacement Coefficient of Soil Surrounding Pile in Layered Foundations by Considering the Soil Mass’s Longitudinal Continuity

    Directory of Open Access Journals (Sweden)

    Yao Wen-Juan

    2013-01-01

    Full Text Available When utilizing the p-y curve to simulate the nonlinear characteristics of soil surrounding pile in layered foundations, due to having not taken into account the soil mass’s longitudinal continuity, the calculation deviation of horizontal displacement increases with the growth of a load. This paper adopted the layered elasticity system theory to consider the soil mass’s longitudinal continuity, as well as utilizing the research method for layered isotropic bodies, assuming that the horizontal resistance is evenly distributed around the perimeter of the pile's cross-section. Then an appropriate transfer matrix method of horizontal displacement coefficient for the soil surrounding pile in layered foundations was established. According to the calculation principle of finite element equivalent load, the horizontal displacement coefficient matrix was deduced as well as providing a corrected formula for the horizontal displacement of soil surrounding pile through the p-y curve method when the external load was increased. Following the established model, a program was created which was used for calculating and analyzing the horizontal displacement coefficient matrix of three-layered soil in order to verify this method’s validity and rationale. Where there is a relatively large discrepancy in the soil layers’ properties, this paper’s method is able to reflect the influence on the layered soil’s actual distributional difference as well as the nearby soil layers’ interaction.

  19. A Foundational Analysis of Dorothea Orem's Self-Care Theory and Evaluation of Its Significance for Nursing Practice and Research.

    Science.gov (United States)

    Younas, Ahtisham

    2017-02-01

    In-depth understanding of the ontological and epistemological assumptions of nursing theories can be achieved through theory analysis. Several theory analysis criteria have been proposed for examining ontological and epistemological assumptions, but there are limited examples of actual analysis of these assumptions. This article presents an analysis of the ontological and epistemological assumptions of Dorothea Orem's selfcare theory and evaluates its significance for nursing practice and research.

  20. A strategy for the generation, characterization and distribution of animal models by The Michael J. Fox Foundation for Parkinson’s Research

    Directory of Open Access Journals (Sweden)

    Marco A. S. Baptista

    2013-11-01

    Full Text Available Progress in Parkinson’s disease (PD research and therapeutic development is hindered by many challenges, including a need for robust preclinical animal models. Limited availability of these tools is due to technical hurdles, patent issues, licensing restrictions and the high costs associated with generating and distributing these animal models. Furthermore, the lack of standardization of phenotypic characterization and use of varying methodologies has made it difficult to compare outcome measures across laboratories. In response, The Michael J. Fox Foundation for Parkinson’s Research (MJFF is directly sponsoring the generation, characterization and distribution of preclinical rodent models, enabling increased access to these crucial tools in order to accelerate PD research. To date, MJFF has initiated and funded the generation of 30 different models, which include transgenic or knockout models of PD-relevant genes such as Park1 (also known as Park4 and SNCA, Park8 (LRRK2, Park7 (DJ-1, Park6 (PINK1, Park2 (Parkin, VPS35, EiF4G1 and GBA. The phenotypic characterization of these animals is performed in a uniform and streamlined manner at independent contract research organizations. Finally, MJFF created a central repository at The Jackson Laboratory (JAX that houses both non-MJFF and MJFF-generated preclinical animal models. Funding from MJFF, which subsidizes the costs involved in transfer, rederivation and colony expansion, has directly resulted in over 2500 rodents being distributed to the PD community for research use.

  1. Oral Cancer Foundation

    Science.gov (United States)

    ... survivors and caregivers. Join or Login Today! The Oral Cancer Foundation The Oral Cancer Foundation is a national ... Find an OCF Event. OCF Sitemap Sitemap The Oral Cancer Foundation 3419 Via Lido #205 Newport Beach Ca ...

  2. Web services foundations

    CERN Document Server

    Bouguettaya, Athman; Daniel, Florian

    2013-01-01

    Web services and Service-Oriented Computing (SOC) have become thriving areas of academic research, joint university/industry research projects, and novel IT products on the market. SOC is the computing paradigm that uses Web services as building blocks for the engineering of composite, distributed applications out of the reusable application logic encapsulated by Web services. Web services could be considered the best-known and most standardized technology in use today for distributed computing over the Internet.Web Services Foundations is the first installment of a two-book collection coverin

  3. Corporate Ownership by Industrial Foundations

    DEFF Research Database (Denmark)

    Thomsen, Steen

    1999-01-01

    to be relatively inefficient since they lack monitoring by residual claimants and access to equity finance from the stock market. Nevertheless, empirical research (Thomsen 1996) has found that Danish foundation-owned companies do no worse in terms of profitability and growth than companies with dispersed ownership......Industrial foundations are self-governing non profit institutions that own business companies. This ownership structure is found in a fair number of Northern European companies, some of them successful world class competitors. Standard agency theory would predict foundation-owned companies...

  4. PREFACE: International Scientific and Research Conference on Topical Issues in Aeronautics and Astronautics (dedicated to the 55th anniversary from the foundation of SibSAU)

    Science.gov (United States)

    2015-10-01

    The International Scientific and Research Conference ''Topical Issues in Aeronautics and Astronautics'' is one of the most significant scientific conferences arranged by the Reshetnev Siberian State Aerospace University (SibSAU) which is located in the Krasnoyarsk Region of Russian Federation. In April 2015 this Conference was dedicated to the 55th anniversary from the foundation of the University. Traditionally, the Conference is seen as emblematic of the University's specialty and is annually organized in April, when the first human travelled into space. This Conference is arranged for undergraduate, graduate and postgraduate students, scientists and lecturers, as well as developers, designers and constructors representing leading companies and enterprises of the aerospace sector to give opportunities to present their projects, research work and results. The Conference is a great chance to connect scientists and highly-qualified and skilled specialists with a new community of future scientists and practitioners in the aerospace sector. The Conference proceedings include papers presented by creative young specialists closely connected with aviation and space vehicles - design, production, problem-solving in space machine building and aerospace education, macro- and microeconomic development of the field, new approaches to solving philosophical and social problems, - experienced scientists and specialists, and all those who want to dedicate themselves to aeronautics and astronautics. The selected papers are presented in these proceedings to share University research results, innovations and cutting-edge technologies with the international community to develop aeronautics and astronautics on a global scale.

  5. E-learning for research capacity strengthening in sexual and reproductive health: the experience of the Geneva Foundation for Medical Education and Research and the Department of Reproductive Health and Research, World Health Organization.

    Science.gov (United States)

    Abawi, Karim; Chandra-Mouli, Venkatraman; Toskin, Igor; Festin, Mario Philip; Gertiser, Lynn; Idris, Raqibat; Hamamy, Hanan; Ali, Moazzam; Bonventure, Ameyo Masakhwe; Temmerman, Marleen; Campana, Aldo

    2016-12-07

    Technological advancement has resulted in the increasing use of e-learning and online education, initially in high-income countries and increasingly in low- and middle-income countries. In 2010, the Geneva Foundation for Medical Education and Research, in collaboration with the World Health Organization and partner institutions, developed an online postgraduate course "From Research to Practice: Training Course in Sexual and Reproductive Health Research". This course takes advantage of the advancing Internet technology to provide training opportunities to health professionals mostly from low- and middle-income countries whose access to quality education is constrained by time, financial resources, or both. To assess the outcomes of the course, an evaluation was conducted by sending a self-administered questionnaire to graduates of the 2010-2012 programme. The objectives were to determine if the graduates had applied the knowledge gained from the course to their work and whether they had implemented their research project developed during the course. The evaluation also appraised the number of graduates who participated in the design or implementation of a new research project since the course concluded and whether the course had contributed to advancement in their careers. A total of 175 of 219 course graduates answered the questionnaire. The evaluation revealed that the majority of respondents (98%) had utilized the knowledge acquired, with nearly half of them (47%) having published a scientific paper as author or co-author. About a third of respondents (39%) had implemented their course research project and about three quarters of them (74%) have been involved in the design or implementation of a research project after completing the course. Over three quarters (81%) of respondents opined that the course had contributed to their career advancement and almost half of them (46%) had a career promotion as a direct or indirect benefit of the course. We surmise that

  6. Foundations of genetic algorithms 1991

    CERN Document Server

    1991-01-01

    Foundations of Genetic Algorithms 1991 (FOGA 1) discusses the theoretical foundations of genetic algorithms (GA) and classifier systems.This book compiles research papers on selection and convergence, coding and representation, problem hardness, deception, classifier system design, variation and recombination, parallelization, and population divergence. Other topics include the non-uniform Walsh-schema transform; spurious correlations and premature convergence in genetic algorithms; and variable default hierarchy separation in a classifier system. The grammar-based genetic algorithm; condition

  7. Different prelamin A forms accumulate in human fibroblasts: a study in experimental models and progeria

    Directory of Open Access Journals (Sweden)

    S Dominici

    2009-08-01

    Full Text Available Lamin A is a component of the nuclear lamina mutated in a group of human inherited disorders known as laminopathies. Among laminopathies, progeroid syndromes and lipodystrophies feature accumulation of prelamin A, the precursor protein which, in normal cells, undergoes a multi-step processing to yield mature lamin A. It is of utmost importance to characterize the prelamin A form accumulated in each laminopathy, since existing evidence shows that drugs acting on protein processing can improve some pathological aspects.We report that two antibodies raised against differently modified prelamin A peptides show a clear specificity to full-length prelamin A or carboxymethylated farnesylated prelamin A, respectively. Using these antibodies, we demonstrated that inhibition of the prelamin A endoprotease ZMPSTE24 mostly elicits accumulation of full-length prelamin A in its farnesylated form, while loss of the prelamin A cleavage site causes accumulation of carboxymethylated prelamin A in progeria cells. These results suggest a major role of ZMPSTE24 in the first prelamin A cleavage step.

  8. Sporadic premature aging in a Japanese monkey: a primate model for progeria.

    Directory of Open Access Journals (Sweden)

    Takao Oishi

    Full Text Available In our institute, we have recently found a child Japanese monkey who is characterized by deep wrinkles of the skin and cataract of bilateral eyes. Numbers of analyses were performed to identify symptoms representing different aspects of aging. In this monkey, the cell cycle of fibroblasts at early passage was significantly extended as compared to a normal control. Moreover, both the appearance of senescent cells and the deficiency in DNA repair were observed. Also, pathological examination showed that this monkey has poikiloderma with superficial telangiectasia, and biochemical assay confirmed that levels of HbA1c and urinary hyaluronan were higher than those of other (child, adult, and aged monkey groups. Of particular interest was that our MRI analysis revealed expansion of the cerebral sulci and lateral ventricles probably due to shrinkage of the cerebral cortex and the hippocampus. In addition, the conduction velocity of a peripheral sensory but not motor nerve was lower than in adult and child monkeys, and as low as in aged monkeys. However, we could not detect any individual-unique mutations of known genes responsible for major progeroid syndromes. The present results indicate that the monkey suffers from a kind of progeria that is not necessarily typical to human progeroid syndromes.

  9. Different prelamin A forms accumulate in human fibroblasts: a study in experimental models and progeria

    Directory of Open Access Journals (Sweden)

    G Lattanzi

    2009-03-01

    Full Text Available Lamin A is a component of the nuclear lamina mutated in a group of human inherited disorders known as laminopathies. Among laminopathies, progeroid syndromes and lipodystrophies feature accumulation of prelamin A, the precursor protein which, in normal cells, undergoes a multi-step processing to yield mature lamin A. It is of utmost importance to characterize the prelamin A form accumulated in each laminopathy, since existing evidence shows that drugs acting on protein processing can improve some pathological aspects.We report that two antibodies raised against differently modified prelamin A peptides show a clear specificity to full-length prelamin A or carboxymethylated farnesylated prelamin A, respectively. Using these antibodies, we demonstrated that inhibition of the prelamin A endoprotease ZMPSTE24 mostly elicits accumulation of full-length prelamin A in its farnesylated form, while loss of the prelamin A cleavage site causes accumulation of carboxymethylated prelamin A in progeria cells. These results suggest a major role of ZMPSTE24 in the first prelamin A cleavage step.

  10. Transgene silencing of the Hutchinson-Gilford progeria syndrome mutation results in a reversible bone phenotype, whereas resveratrol treatment does not show overall beneficial effects

    DEFF Research Database (Denmark)

    Strandgren, Charlotte; Nasser, Hasina Abdul; McKenna, Tomás

    2015-01-01

    Hutchinson-Gilford progeria syndrome (HGPS) is a rare premature aging disorder that is most commonly caused by a de novo point mutation in exon 11 of the LMNA gene, c.1824C>T, which results in an increased production of a truncated form of lamin A known as progerin. In this study, we used a mouse...... progerin splicing give hope to patients who are affected by HGPS.-Strandgren, C., Nasser, H. A., McKenna, T., Koskela, A., Tuukkanen, J., Ohlsson, C., Rozell, B., Eriksson, M. Transgene silencing of the Hutchinson-Gilford progeria syndrome mutation results in a reversible bone phenotype, whereas...

  11. Justification of parameters and selection of equipment for laboratory researches of a rammer's operating element dynamics in a soil foundation of a tank for oil and oil products storage

    Science.gov (United States)

    Gruzin, A. V.; Gruzin, V. V.; Shalay, V. V.

    2017-08-01

    The development of technology for a directional soil compaction of tank foundations for oil and oil products storage is a relevant problem which solution will enable simultaneously provide required operational characteristics of a soil foundation and reduce time and material costs to prepare the foundation. The impact dynamics of rammers' operating elements on the soil foundation is planned to specify in the course of laboratory studies. A specialized technique is developed to justify the parameters and select the equipment for laboratory researches. The usage of this technique enabled us to calculate dimensions of the models, of a test bench and specifications of the recording equipment, and a lighting system. The necessary equipment for laboratory studies was selected. Preliminary laboratory tests were carried out. The estimate of accuracy for planned laboratory studies was given.

  12. Cushing's Support and Research Foundation

    Science.gov (United States)

    ... Overlays Share Tweet Previous Next Previous Next News Cushing’s Disease book released Cushing’s Disease: An Often Misdiagnosed ... of the CSRF, is now available. LEARN MORE > Cushing's Patient Day Summaries and Videos Available On March ...

  13. Characteristic Behavior of Bucket Foundations

    DEFF Research Database (Denmark)

    Barari, Amin

    engineering experiments to gain insight into the behavior of offshore bucket foundations, and development of methods to improve the study of infiltration intounsaturated soils, an important problem in geo-environmental engineering. The outcomes of the research have the potential to directly or indirectly...... reduce the risks and costsrelated to offshore geotechnics. The thesis examines: 1.Characteristic Behavior of Bucket Foundations 2. Modeling of Water Flow through Porous Media The outcomes of each of the research contributions are summarized in four research articles, either directly or indirectly...

  14. Foundation Ownership, Reputation, and Labour

    DEFF Research Database (Denmark)

    Børsting, Christa Winther; Thomsen, Steen

    2017-01-01

    of profitability and growth, despite lacking governance mechanisms such as profit incentives or takeover threats. Given their non-profit ownership, they might be expected to behave more responsibly towards stakeholders, such as employees or customers (Hansmann, 1980), but so far there has been little empirical...... evidence to support this hypothesis. This paper presents new research on the reputation and responsibility of foundation-owned companies. In a panel of large Danish companies 2001–11 we find that foundation-owned firms have better reputations and are regarded as more socially responsible in corporate image...... ratings. Secondary evidence on labour market behaviour is consistent with these findings. Using matched employer–employee data we show that foundation-owned companies are more stable employers, pay their employees better, and keep them for longer. Altogether, the evidence indicates that foundation...

  15. Transient monoparesis following blade plate removal in a Hutchinson-Gilford progeria syndrome patient. A case report

    Science.gov (United States)

    Yandow, Suzanne M.; Rimoin, David L.; Grace, Aimee M.; Fillman, Ramona R.; Raney, Ellen M.

    2010-01-01

    Treating patients with Hutchinson-Gilford progeria syndrome (HGPS) are based on the abnormalities of accelerated aging that affect the healing processes, combined with a fragile cardiovascular status. A classic HGPS case is presented, of Korean ancestry, who was treated for severe coxa valga with bilateral varus osteotomies using blade plate fixation. Complications over the blade plate area required removal of the hardware, after which the patient displayed left-sided hypertonicity--determined to be a cerebrovascular accident. Subsequently, she returned almost completely to her pre-surgical neurologic status. Perioperative planning for HGPS patients should include risks typically considered in the planning for geriatric patient care. PMID:19373113

  16. Toxicology Education Foundation

    Science.gov (United States)

    ... bodies and our world. Welcome to the Toxicology Education Foundation! Our mission is to enhance public understanding ... In with us, follow our Tweets, choose Toxicology Education Foundation as your preferred charity through Smile.Amazon. ...

  17. Virginia 4-H Foundation

    OpenAIRE

    2012-01-01

    The Virginia 4-H Foundation is a portfolio of accounts within the Virginia Tech Foundation. This publication describes the portfolio in terms of finance, restrictions, fund-development, areas of emphasis, and meet times.

  18. Skin Cancer Foundation

    Science.gov (United States)

    ... Host a Fundraising Event | About Us | Store The Skin Cancer Foundation The Skin Cancer Foundation is the only ... Handbook A "Sunscreen Gene"? Skin Cancer Facts & Statistics Skin Cancer Treatment Glossary Information on medications and procedures The ...

  19. Melanoma International Foundation

    Science.gov (United States)

    ... Luke, MD January 07, 2016 Our Awards Melanoma International Foundation Our Mission: To develop personalized strategies with ... the state of Pennsylvania, certificate #29498 © 2013 Melanoma International Foundation. All Rights Reserved. Privacy Policy | Terms of ...

  20. Proteus Syndrome Foundation

    Science.gov (United States)

    ... Gift Stock Gift Sunshine Society Contact Privacy Policy Proteus Syndrome Foundation CLICK HERE to watch Dr. Leslie ... 1 Trial with ARQ 092 in Proteus Syndrome Proteus Syndrome Patient Registry The Proteus Syndrome Foundation Contact ...

  1. Osteogenesis Imperfecta Foundation

    Science.gov (United States)

    ... Better Bones Upcoming Events Online Store What is Osteogenesis Imperfecta? Osteogenesis Imperfecta (OI) is a genetic bone disorder ... known as "brittle bone disease." Learn More The Osteogenesis Imperfecta Foundation The OI Foundation provides medically verified information ...

  2. Alport Syndrome Foundation

    Science.gov (United States)

    ... Groups Hear From the Experts Follow us on Facebook! Alport Syndrome Foundation of USA 1 day ago ... 2017. Karol provided an ov... Video View on Facebook · Share View on Facebook The Alport syndrome Foundation ...

  3. Pulmonary Fibrosis Foundation

    Science.gov (United States)

    ... the most current news and updates from the Pulmonary Fibrosis Foundation. Life with PF Education & Support About PF ... abstract submissions. MORE We Imagine a World Without Pulmonary Fibrosis The Pulmonary Fibrosis Foundation mobilizes people and resources ...

  4. Adaptive stress response in segmental progeria resembles long-lived dwarfism and calorie restriction in mice.

    Directory of Open Access Journals (Sweden)

    Marieke van de Ven

    2006-12-01

    Full Text Available How congenital defects causing genome instability can result in the pleiotropic symptoms reminiscent of aging but in a segmental and accelerated fashion remains largely unknown. Most segmental progerias are associated with accelerated fibroblast senescence, suggesting that cellular senescence is a likely contributing mechanism. Contrary to expectations, neither accelerated senescence nor acute oxidative stress hypersensitivity was detected in primary fibroblast or erythroblast cultures from multiple progeroid mouse models for defects in the nucleotide excision DNA repair pathway, which share premature aging features including postnatal growth retardation, cerebellar ataxia, and death before weaning. Instead, we report a prominent phenotypic overlap with long-lived dwarfism and calorie restriction during postnatal development (2 wk of age, including reduced size, reduced body temperature, hypoglycemia, and perturbation of the growth hormone/insulin-like growth factor 1 neuroendocrine axis. These symptoms were also present at 2 wk of age in a novel progeroid nucleotide excision repair-deficient mouse model (XPD(G602D/R722W/XPA(-/- that survived weaning with high penetrance. However, despite persistent cachectic dwarfism, blood glucose and serum insulin-like growth factor 1 levels returned to normal by 10 wk, with hypoglycemia reappearing near premature death at 5 mo of age. These data strongly suggest changes in energy metabolism as part of an adaptive response during the stressful period of postnatal growth. Interestingly, a similar perturbation of the postnatal growth axis was not detected in another progeroid mouse model, the double-strand DNA break repair deficient Ku80(-/- mouse. Specific (but not all types of genome instability may thus engage a conserved response to stress that evolved to cope with environmental pressures such as food shortage.

  5. From the NSF: The National Science Foundation's Investments in Broadening Participation in Science, Technology, Engineering, and Mathematics Education through Research and Capacity Building.

    Science.gov (United States)

    James, Sylvia M; Singer, Susan R

    The National Science Foundation (NSF) has a long history of investment in broadening participation (BP) in science, technology, engineering, and mathematics (STEM) education. A review of past NSF BP efforts provides insights into how the portfolio of programs and activities has evolved and the broad array of innovative strategies that has been used to increase the participation of groups underrepresented in STEM, including women, minorities, and persons with disabilities. While many are familiar with these long-standing programmatic efforts, BP is also a key component of NSF's strategic plans, has been highlighted in National Science Board reports, and is the focus of ongoing outreach efforts. The majority of familiar BP programs, such as the Louis Stokes Alliances for Minority Participation (now 25 years old), are housed in the Directorate for Education and Human Resources. However, fellowship programs such as the Graduate Research Fellowships and Postdoctoral Research Fellowships under the Directorate for Biological Sciences (and parallel directorates in other STEM disciplines) are frequently used to address underrepresentation in STEM disciplines. The FY2016 and FY2017 budget requests incorporate funding for NSF INCLUDES, a new cross-agency BP initiative that will build on prior successes while addressing national BP challenges. NSF INCLUDES invites the use of innovative approaches for taking evidence-based best practices to scale, ushering in a new era in NSF BP advancement. © 2016 S. M. James and S. R. Singer. CBE—Life Sciences Education © 2016 The American Society for Cell Biology. This article is distributed by The American Society for Cell Biology under license from the author(s). It is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

  6. Environmental Foundations in Germany

    Directory of Open Access Journals (Sweden)

    Thomas Krikser

    2015-05-01

    Full Text Available Foundations in Germany were examined in the context of environmental issues. Data from environmental foundations show that there is huge difference between private and public foundations concerning financial settings. Furthermore, environment is often not the only objective and sometimes not even processed. Our analysis shows that there are different types of foundations with regard to environmental scopes and activities. Although “attractive topics” such as biodiversity and landscape conservation seem to be more important to foundations, less visible topics such as pollution prevention remain merely a “blind spot.” Together, these findings suggest that there is only a limited potential of private foundations compared with public foundations. Nevertheless, there might be an impact on environmental awareness and local sustainability.

  7. Foundations of quantum gravity

    CERN Document Server

    Lindesay, James

    2013-01-01

    Exploring how the subtleties of quantum coherence can be consistently incorporated into Einstein’s theory of gravitation, this book is ideal for researchers interested in the foundations of relativity and quantum physics. The book examines those properties of coherent gravitating systems that are most closely connected to experimental observations. Examples of consistent co-gravitating quantum systems whose overall effects upon the geometry are independent of the coherence state of each constituent are provided, and the properties of the trapping regions of non-singular black objects, black holes, and a dynamic de Sitter cosmology are discussed analytically, numerically, and diagrammatically. The extensive use of diagrams to summarise the results of the mathematics enables readers to bypass the need for a detailed understanding of the steps involved. Assuming some knowledge of quantum physics and relativity, the book provides textboxes featuring supplementary information for readers particularly interested ...

  8. Scour Development Around Bucket Foundations

    DEFF Research Database (Denmark)

    Stroescu, Ionut Emanuel; Frigaard, Peter Bak; Fejerskov, Morten

    2016-01-01

    A wind turbine foundation design without scour protection, especially for wind turbines in the North Sea, is a sensitive topic for most offshore developers. However, recent research shows that this concept is realistic if there is extended comprehension of the scour and backfill phenomena. The pr...

  9. [Analysis on Research Projects Supported by the National Natural Science Foundation of China at the National Institute of Parasitic Diseases during 2003-2013].

    Science.gov (United States)

    Zhou, Xiao-jun; Zheng, Bin; Yi, Feng-yun; Xiong, Yan-hong; Zhang, Min-qi

    2015-04-01

    The data of the National Natural Science Foundation (NSFC) projests obtained by the National Institute of Parasitic Diseases (NIPD), Chinese Center for Disease Control and Prevention (China CDC) during 2003-2013 were collected from internet-based science information system of NSFC, and NSFC search tool of Dingxiang Garden (http://nsfc.biomart.cn/). The number of funded projects, their subject classification and approved amount were analyzed, and compared with the other institutes of China CDC. Furthermore, the rationalization proposals were given in order to enhance the level of foundation management in the future.

  10. Partial lipodystrophy with severe insulin resistance and adult progeria Werner syndrome.

    Science.gov (United States)

    Donadille, Bruno; D'Anella, Pascal; Auclair, Martine; Uhrhammer, Nancy; Sorel, Marc; Grigorescu, Romulus; Ouzounian, Sophie; Cambonie, Gilles; Boulot, Pierre; Laforêt, Pascal; Carbonne, Bruno; Christin-Maitre, Sophie; Bignon, Yves-Jean; Vigouroux, Corinne

    2013-07-12

    Laminopathies, due to mutations in LMNA, encoding A type-lamins, can lead to premature ageing and/or lipodystrophic syndromes, showing that these diseases could have close physiopathological relationships. We show here that lipodystrophy and extreme insulin resistance can also reveal the adult progeria Werner syndrome linked to mutations in WRN, encoding a RecQ DNA helicase. We analysed the clinical and biological features of two women, aged 32 and 36, referred for partial lipodystrophic syndrome which led to the molecular diagnosis of Werner syndrome. Cultured skin fibroblasts from one patient were studied. Two normal-weighted women presented with a partial lipodystrophic syndrome with hypertriglyceridemia and liver steatosis. One of them had also diabetes. Both patients showed a peculiar, striking lipodystrophic phenotype with subcutaneous lipoatrophy of the four limbs contrasting with truncal and abdominal fat accumulation. Their oral glucose tolerance tests showed extremely high levels of insulinemia, revealing major insulin resistance. Low serum levels of sex-hormone binding globulin and adiponectin suggested a post-receptor insulin signalling defect. Other clinical features included bilateral cataracts, greying hair and distal skin atrophy. We observed biallelic WRN null mutations in both women (p.Q748X homozygous, and compound heterozygous p.Q1257X/p.M1329fs). Their fertility was decreased, with preserved menstrual cycles and normal follicle-stimulating hormone levels ruling out premature ovarian failure. However undetectable anti-müllerian hormone and inhibin B indicated diminished follicular ovarian reserve. Insulin-resistance linked ovarian hyperandrogenism could also contribute to decreased fertility, and the two patients became pregnant after initiation of insulin-sensitizers (metformin). Both pregnancies were complicated by severe cervical incompetence, leading to the preterm birth of a healthy newborn in one case, but to a second trimester

  11. The Reflective Foundation

    DEFF Research Database (Denmark)

    Lunde Jørgensen, Ida

    Private foundations and cultural philanthropy by élites is viewed with increasing skepticism in recent years, begging the question of the extent to which foundations reflect on their role vis a vis wider societal norms. Through the prism of the New Carlsberg Foundation, financed by the brewery...... Carlsberg A/S, the paper seeks to elucidate the way in which one culturally significant foundation from Denmark has reflected on - and legitimated - its work and investments at critical moments in the past decades. The paper indicates a foundation with a high degree of reflection on the wider societal...... pressures, and position as a mediator between culture and capital. The paper draws inspiration from the institutional logics perspective and Boltanski and Thévenot’s convention theoretical work, to analyse the legitimations pursued by the foundation....

  12. Building Capacity in Understanding Foundational Biology Concepts: A K-12 Learning Progression in Genetics Informed by Research on Children's Thinking and Learning

    Science.gov (United States)

    Elmesky, Rowhea

    2013-01-01

    This article describes the substance, structure, and rationale of a learning progression in genetics spanning kindergarten through twelfth grade (K-12). The learning progression is designed to build a foundation towards understanding protein structure and activity and should be viewed as one possible pathway to understanding concepts of genetics…

  13. From the NSF: The National Science Foundation's Investments in Broadening Participation in Science, Technology, Engineering, and Mathematics Education through Research and Capacity Building

    Science.gov (United States)

    James, Sylvia M.; Singer, Susan R.

    2016-01-01

    The National Science Foundation (NSF) has a long history of investment in broadening participation (BP) in science, technology, engineering, and mathematics (STEM) education. A review of past NSF BP efforts provides insights into how the portfolio of programs and activities has evolved and the broad array of innovative strategies that has been…

  14. Developing and Evaluating an Eighth Grade Curriculum Unit That Links Foundational Chemistry to Biological Growth: Changing the Research-Based Curriculum

    Science.gov (United States)

    Kruse, Rebecca; Howes, Elaine V.; Carlson, Janet; Roth, Kathleen; Bourdelat-Parks, Brooke; Roseman, Jo Ellen; Herrmann-Abell, Cari F.; Flanagan, Jean C.

    2013-01-01

    Much of modern biology has become increasingly chemical in character. Not surprisingly, students often have trouble understanding key ideas in biology because they lack foundational chemistry ideas. AAAS and BSCS are collaborating to develop and study a curriculum unit that supports students' ability to explain a variety of biological processes…

  15. Moebius Syndrome Foundation

    Science.gov (United States)

    ... friends and relatives For professionals Treatment options Video introduction to Moebius syndrome Who we are Mission and History Foundation leadership Scientific advisory board Press room Our stories Financial ...

  16. 從課程學理基礎與核心素養論K-12 年級課程綱要A Research on Curriculum Theoretical Foundations and Key Competencies of K-12 Curriculum Guideline in

    Directory of Open Access Journals (Sweden)

    蔡清田Ching-Tien Tsai

    2011-09-01

    Full Text Available 本研究結合了研究者近年主持的兩件整合型研究計畫初步成果,包括國家教育研究院所委託執行的「K-12中小學一貫課程綱要核心素養與各領域之連貫體系研究」與「中小學課程相關之課程、教學、認知發展等學理基礎與理論趨向」,這些研究旨在建立我國未來幼兒教育、初等教育、前期中等教育及後期中等教育的「K-12年級課程綱要」之課程發展學理基礎,預備下一波課程改革。本文從核心素養與課程學理的教育哲學、教學理論、認知心理學、文化研究與社會變遷等角度切入,分析課程發展相關學理基礎,並依據課程學理與核心素養研究,對我國「K-12年級課程綱要」的基本理念、課程目標、核心素養、學習領域及實施通則等提出建議,冀能提升我國國民核心素養。 The main goal of this research aims to build theoretical foundations of curriculum development in order to prepare for the next curriculum reform regarding the K-12 curriculum guideline in Taiwan. So far as theoretical foundations of curriculum development is concerned, this research focuses on the relationships between key competencies and curriculum theoretical foundations regarding with five theoretical dimensions – educational philosophy, teaching theory, cognitive psychology, cultural studies and social change. First, the researcher analyses key competencies and theoretical foundations of curriculum development according to the literature review of the related curriculum theories and related studies. Second, the researcher builds up a set of theoretical foundations regarding curriculum development which is suitable for Taiwanese historical and cultural contexts. Finally, according to the new set of curriculum theoretical foundations, the researcher makes some suggestions for the future K-12 curriculum guidelines in Taiwan.

  17. Liberating Foundations of Art and Design

    Science.gov (United States)

    Lerner, Fern

    2012-01-01

    Research concerning the basic course known as Foundations of Art and Design strengthens the pedagogical approach for K-16 art and design education. The version of Foundations introduced to America by Josef Albers, although hardly changed, is shown to have continued, timeless relevance. Next, a sequential, implicit logic is revealed in linking the…

  18. On Ultimate Epistemic Foundations

    NARCIS (Netherlands)

    van Woudenberg, R.

    1995-01-01

    This paper is a contribution to the debate on epistemic foundationalism. Section I expounds and criticises Hans Albert's critical rationalist antifoundationalism position. Section I1 discusses Karl‐Otto Apel's ‘transcendental pragmatic’ argument for ultimate epistemic foundations. Section III

  19. Establishing a School Foundation.

    Science.gov (United States)

    Erickson, Juanita; Stewart, G. Kent

    2002-01-01

    A school foundation is a nonprofit, tax-exempt organization that finances school projects not covered by the district budget. Legal requirements and accounting procedures; the board of trustees and fund manager; use of volunteers; capitalization and sources of capital (gifts, bequests, fundraising activities); marketing the foundation; examples of…

  20. Foundations for Critical Thinking

    Science.gov (United States)

    Bers, Trudy; Chun, Marc; Daly, William T.; Harrington, Christine; Tobolowsky, Barbara F.

    2015-01-01

    "Foundations for Critical Thinking" explores the landscape of critical-thinking skill development and pedagogy through foundational chapters and institutional case studies involving a range of students in diverse settings. By establishing a link between active learning and improved critical thinking, this resource encourages all higher…

  1. The Monopod Bucket Foundation

    DEFF Research Database (Denmark)

    Bakmar, Christian LeBlanc; Ahle, Kim; Nielsen, Søren A.

    2009-01-01

    Following the successful installation of a prototype of a monopod bucket foundation, also called a “monopod suction caisson”, at Horns Rev 2 Offshore Wind Farm, Denmark, in 2009, DONG Energy is currently developing a commercialization strategy. The monopod bucket foundation is a promising...

  2. National Reye's Syndrome Foundation

    Science.gov (United States)

    ... a great way to learn even more about aspirin and children, and get tips and hints about a range ... Foundation's LinkedIn profile Spread Awareness with the Kids & Aspirin Don't Mix ... In 1974, the National Reye's Syndrome Foundation, a children's health advocacy organization, was incorporated as a 501( ...

  3. BrightFocus Foundation

    Science.gov (United States)

    ... sooner. More science news Help us find a cure. Give to BrightFocus BrightFocus Updates BrightFocus Foundation Lauds Bill Gates Alzheimer’s Initiative “BrightFocus Foundation lauds today’s historic announcement by ...

  4. Case study and case-based research in emergency nursing and care: Theoretical foundations and practical application in paramedic pre-hospital clinical judgment and decision-making of patients with mental illness.

    Science.gov (United States)

    Shaban, Ramon Z; Considine, Julie; Fry, Margaret; Curtis, Kate

    2017-02-01

    Generating knowledge through quality research is fundamental to the advancement of professional practice in emergency nursing and care. There are multiple paradigms, designs and methods available to researchers to respond to challenges in clinical practice. Systematic reviews, randomised control trials and other forms of experimental research are deemed the gold standard of evidence, but there are comparatively few such trials in emergency care. In some instances it is not possible or appropriate to undertake experimental research. When exploring new or emerging problems where there is limited evidence available, non-experimental methods are required and appropriate. This paper provides the theoretical foundations and an exemplar of the use of case study and case-based research to explore a new and emerging problem in the context of emergency care. It examines pre-hospital clinical judgement and decision-making of mental illness by paramedics. Using an exemplar the paper explores the theoretical foundations and conceptual frameworks of case study, it explains how cases are defined and the role researcher in this form of inquiry, it details important principles and the procedures for data gathering and analysis, and it demonstrates techniques to enhance trustworthiness and credibility of the research. Moreover, it provides theoretically and practical insights into using case study in emergency care. Copyright © 2017 College of Emergency Nursing Australasia. Published by Elsevier Ltd. All rights reserved.

  5. Using drug treatments to control genome behaviour in normal and Hutchinson-Gilford Progeria Syndrome fibroblasts, with and without hTERT immortalisation

    OpenAIRE

    Bikkul, Mehmet Ural

    2016-01-01

    This thesis was submitted for the award of Doctor of Philosophy and was awarded by Brunel University London Hutchinson-Gilford Progeria Syndrome (HGPS) is an exceedingly rare genetic condition with striking features reminiscent of marked premature ageing. HGPS is commonly caused by a ‘classic’ mutation in the A-type lamin gene, LMNA (G608G). This leads to the expression of an aberrant truncated lamin A protein, progerin. The nuclear lamina is known to anchor chromosomes, stabilising and re...

  6. Blocking protein farnesylation improves nuclear shape abnormalities in keratinocytes of mice expressing the prelamin A variant in Hutchinson-Gilford progeria syndrome

    OpenAIRE

    Wang, Yuexia; Östlund, Cecilia; Worman, Howard J

    2010-01-01

    Hutchinson-Gilford progeria syndrome (HGPS) is an accelerated aging disorder caused by mutations in LMNA leading to expression of a truncated prelamin A variant termed progerin. Whereas a farnesylated polypeptide is normally removed from the carboxyl-terminus of prelamin A during endoproteolytic processing to lamin A, progerin lacks the cleavage site and remains farnesylated. Cultured cells from human subjects with HGPS and genetically modified mice expressing progerin have nuclear morphologi...

  7. Cognitive Foundations for Visual Analytics

    Energy Technology Data Exchange (ETDEWEB)

    Greitzer, Frank L.; Noonan, Christine F.; Franklin, Lyndsey

    2011-02-25

    In this report, we provide an overview of scientific/technical literature on information visualization and VA. Topics discussed include an update and overview of the extensive literature search conducted for this study, the nature and purpose of the field, major research thrusts, and scientific foundations. We review methodologies for evaluating and measuring the impact of VA technologies as well as taxonomies that have been proposed for various purposes to support the VA community. A cognitive science perspective underlies each of these discussions.

  8. The Defective Nuclear Lamina in Hutchinson-Gilford Progeria Syndrome Disrupts the Nucleocytoplasmic Ran Gradient and Inhibits Nuclear Localization of Ubc9▿

    Science.gov (United States)

    Kelley, Joshua B.; Datta, Sutirtha; Snow, Chelsi J.; Chatterjee, Mandovi; Ni, Li; Spencer, Adam; Yang, Chun-Song; Cubeñas-Potts, Caelin; Matunis, Michael J.; Paschal, Bryce M.

    2011-01-01

    The mutant form of lamin A responsible for the premature aging disease Hutchinson-Gilford progeria syndrome (termed progerin) acts as a dominant negative protein that changes the structure of the nuclear lamina. How the perturbation of the nuclear lamina in progeria is transduced into cellular changes is undefined. Using patient fibroblasts and a variety of cell-based assays, we determined that progerin expression in Hutchinson-Gilford progeria syndrome inhibits the nucleocytoplasmic transport of several factors with key roles in nuclear function. We found that progerin reduces the nuclear/cytoplasmic concentration of the Ran GTPase and inhibits the nuclear localization of Ubc9, the sole E2 for SUMOylation, and of TPR, the nucleoporin that forms the basket on the nuclear side of the nuclear pore complex. Forcing the nuclear localization of Ubc9 in progerin-expressing cells rescues the Ran gradient and TPR import, indicating that these pathways are linked. Reducing nuclear SUMOylation decreases the nuclear mobility of the Ran nucleotide exchange factor RCC1 in vivo, and the addition of SUMO E1 and E2 promotes the dissociation of RCC1 and Ran from chromatin in vitro. Our data suggest that the cellular effects of progerin are transduced, at least in part, through reduced function of the Ran GTPase and SUMOylation pathways. PMID:21670151

  9. Pediatric Brain Tumor Foundation

    Science.gov (United States)

    ... navigate their brain tumor diagnosis. WATCH AND SHARE Brain tumors and their treatment can be deadly so ... Pediatric Central Nervous System Cancers Read more >> Pediatric Brain Tumor Foundation 302 Ridgefield Court, Asheville, NC 28806 ...

  10. Foundations of laser spectroscopy

    CERN Document Server

    Stenholm, Stig

    2005-01-01

    A simple presentation of the theoretical foundations of steady-state laser spectroscopy, this text helps students to apply theory to calculations with a systematic series of examples and exercises. 1984 edition.

  11. Hepatitis B Foundation

    Science.gov (United States)

    ... worldwide 2 Billion People have been infected with Hepatitis B Worldwide The Hepatitis B Foundation is working ... of people living with hepatitis B. Learn About Hepatitis B in 11 Other Languages . Resource Video See ...

  12. Brain Aneurysm Foundation

    Science.gov (United States)

    ... Megyn Kelly sits down with CNBC’s Senior Personal Finance Correspondent Sharon Epperson to discuss how she survived ... in Touch Stay current with the Brain Aneurysm Foundation. Sign up to receive our newsletter! Please leave ...

  13. American Porphyria Foundation

    Science.gov (United States)

    ... English Español Portuguêse Search form Search About the APF About Porphyria Testing for Porphyria Treatment Options Get ... Gary Eyster Art Sale Featured Items Support the APF The American Porphyria Foundation empowered me to understand ...

  14. Prostate Cancer Foundation News

    Science.gov (United States)

    ... when men who are being treated with androgen deprivation therapy (ADT) see their PSA levels begin to... ... fight against prostate cancer today. Donate Terms of use Privacy Policy © Prostate Cancer Foundation, 2018 Understanding Prostate ...

  15. The foundations of statistics

    CERN Document Server

    Savage, Leonard J

    1972-01-01

    Classic analysis of the foundations of statistics and development of personal probability, one of the greatest controversies in modern statistical thought. Revised edition. Calculus, probability, statistics, and Boolean algebra are recommended.

  16. Foundational aspects of security

    DEFF Research Database (Denmark)

    Chatzikokolakis, Konstantinos; Mödersheim, Sebastian Alexander; Palamidessi, Catuscia

    2014-01-01

    This Special Issue of the Journal of Computer Security focuses on foundational aspects of security, which in recent years have helped change much of the way we think about and approach system security.......This Special Issue of the Journal of Computer Security focuses on foundational aspects of security, which in recent years have helped change much of the way we think about and approach system security....

  17. Foundation trusts. Power sharing.

    Science.gov (United States)

    Jobanputra, Renu; Buchan, James

    2003-05-01

    Foundation trusts will in theory have greater freedoms over pay, non-pay rewards and recruitment, although details are still unclear. Foundations are likely to differ in their use of these powers, partly because of desire and partly because of practical limits. Taking advantage of new powers for short-term gain, at the expense of other trusts, will have negative effects if not part of a wider development of HR practice.

  18. Foundations of Information Theory

    OpenAIRE

    Burgin, Mark

    2008-01-01

    Information is the basic concept of information theory. However, there is no definition of this concept that can encompass all uses of the term information in information theories and beyond. Many question a possibility of such a definition. However, foundations of information theory developed in the context of the general theory of information made it possible to build such a relevant and at the same time, encompassing definition. Foundations of information theory are built in a form of onto...

  19. 30 January 2012 - Danish National Research Foundation Chairman of board K. Bock and University of Copenhagen Rector R. Hemmingsen visiting ATLAS underground experimental area, CERN Control Centre and ALICE underground experimental area, throughout accompanied by J. Dines Hansen and B. Svane Nielsen; signing the guest book with CERN Director for Research and Scientific Computing S. Bertolucci and Head of International Relations F. Pauss.

    CERN Multimedia

    Jean-Claude Gadmer

    2012-01-01

    30 January 2012 - Danish National Research Foundation Chairman of board K. Bock and University of Copenhagen Rector R. Hemmingsen visiting ATLAS underground experimental area, CERN Control Centre and ALICE underground experimental area, throughout accompanied by J. Dines Hansen and B. Svane Nielsen; signing the guest book with CERN Director for Research and Scientific Computing S. Bertolucci and Head of International Relations F. Pauss.

  20. Philosophical foundations of human rights

    CERN Document Server

    Liao, Matthew S

    2015-01-01

    What makes something a human right? What is the relationship between the moral foundations of human rights and human rights law? What are the difficulties of appealing to human rights? This book offers the first comprehensive survey of current thinking on the philosophical foundations of human rights. Divided into four parts, this book focusses firstly on the moral grounds of human rights, for example in our dignity, agency, interests or needs. 'Secondly, it looks at the implications that different moral perspectives on human rights bear for human rights law and politics. Thirdly, it discusses specific and topical human rights including freedom of expression and religion, security, health and more controversial rights such as a human right to subsistence. The final part discusses nuanced critical and reformative views on human rights from feminist, Kantian and relativist perspectives among others. The essays represent new and canonical research by leading scholars in the field. Each part is comprised of a set...

  1. Establishment of a cohort for the long-term clinical follow-up with dose reconstruction under the joint medical research project conducted by Sasakawa Memorial Health Foundation (Japan) and the Research Institute of Radiation Hygine (Russia)

    Energy Technology Data Exchange (ETDEWEB)

    Konstantinov, Y.O.; Bruk, G.Y.; Ershov, E.B. [Research Inst. of Radiation Hygiene, St.Petersburg (Russian Federation)] [and others

    2000-05-01

    The cohort of children in the western districts of the Bryansk Region of Russia exposed to radiation following the Chernobyl accident is described in this paper. The cohort was selected under the Joint Medical Research Project on Dosimetry Associated with the Chernobyl Accident conducted by Sasakawa Memorial Health Foundation (SMHF, Japan) and the Research Institute of Radiation Hygiene (RIRH, Russia). The subjects of the Research Project are those people residing in the most contaminated areas of Russia who was 0 to 10 years old at the time of exposure. At the moment the cohort comprises 1210 subjects, though this number may slightly decrease in course of a follow-up in view of migration of population. Most of cohort subjects were examined on their health status within the framework of the Chernobyl Sasakawa Health and Medical Cooperation Project (CSHMCP) from 1991-1996. In view of the main findings of studies in CSHMCP were thyroid abnormalities, selection of subjects was conducted on the basis of the credible estimates of thyroid dose. Preference for subjects to be included into the cohort was defined by the availability of health examination data from previous study (1991-1996) and individual dosimetry, environmental and social data that may prove useful for reconstruction of individual dose. The primary data analyzed for subjects slection are measurements of iodine-131 in the thyroid in May-June 1986, questionnaire data on individual food habits and early measurements of radiocesium in the body of subjects made by RIRH from May to September 1986. Plausible analytical models were applied to calculate thyroid dose from available data. Previously worked out methods of thyroid dose reconstruction using early measurement data of radiocesium content in the body and questionnaire data on individual consumption of locally produced milk were reevaluated. Basing on these analytical procedures, the individual thyroid dose was ascribed to each member of the cohort. The

  2. CONSTITUTIONAL FOUNDATIONS OF JURISDICTION

    Directory of Open Access Journals (Sweden)

    Alexandre Jamal Batista

    2016-06-01

    Full Text Available At the current stage of our State of Law there is no way to separate the study of the civil procedural law from the Federal Constitution, especially the jurisdiction, because it is in the Constitution that there are the legitimizing foundations of the jurisdiction institute. In this article, we carry on about the constitutional foundations of jurisdiction, such as: the principle of natural justice, principle of access to justice, principle of impartiality, principle of publicity, principle of motivation and principle of submission to res judicata. The conclusion is, after all, that jurisdiction, as one of the bulwarks of the citizen, finds in the “Citizen Constitution” of 1988 its foundations and decisive bases.

  3. Optimization Foundations and Applications

    CERN Document Server

    Miller, H Ronald

    2011-01-01

    A thorough and highly accessible resource for analysts in a broad range of social sciences. Optimization: Foundations and Applications presents a series of approaches to the challenges faced by analysts who must find the best way to accomplish particular objectives, usually with the added complication of constraints on the available choices. Award-winning educator Ronald E. Miller provides detailed coverage of both classical, calculus-based approaches and newer, computer-based iterative methods. Dr. Miller lays a solid foundation for both linear and nonlinear models and quickly moves on to dis

  4. Buckling of Bucket Foundations

    DEFF Research Database (Denmark)

    Madsen, Søren; Andersen, Lars Vabbersgaard; Ibsen, Lars Bo

    2012-01-01

    In this paper, the risk of structural buckling during installation of large-diameter bucket foundations is addressed using numerical methods. Imperfect geometries are introduced based on the pre-buckling mode shapes from a linear Eigenvalue buckling analysis. Various imperfect geometries are intr......In this paper, the risk of structural buckling during installation of large-diameter bucket foundations is addressed using numerical methods. Imperfect geometries are introduced based on the pre-buckling mode shapes from a linear Eigenvalue buckling analysis. Various imperfect geometries...

  5. Foundations of predictive analytics

    CERN Document Server

    Wu, James

    2012-01-01

    Drawing on the authors' two decades of experience in applied modeling and data mining, Foundations of Predictive Analytics presents the fundamental background required for analyzing data and building models for many practical applications, such as consumer behavior modeling, risk and marketing analytics, and other areas. It also discusses a variety of practical topics that are frequently missing from similar texts. The book begins with the statistical and linear algebra/matrix foundation of modeling methods, from distributions to cumulant and copula functions to Cornish--Fisher expansion and o

  6. Foundations of Risk Analysis

    CERN Document Server

    Aven, Terje

    2012-01-01

    Foundations of Risk Analysis presents the issues core to risk analysis - understanding what risk means, expressing risk, building risk models, addressing uncertainty, and applying probability models to real problems. The author provides the readers with the knowledge and basic thinking they require to successfully manage risk and uncertainty to support decision making. This updated edition reflects recent developments on risk and uncertainty concepts, representations and treatment. New material in Foundations of Risk Analysis includes:An up to date presentation of how to understand, define and

  7. Foundations of analysis

    CERN Document Server

    Taylor, Joseph L

    2012-01-01

    Foundations of Analysis is an excellent new text for undergraduate students in real analysis. More than other texts in the subject, it is clear, concise and to the point, without extra bells and whistles. It also has many good exercises that help illustrate the material. My students were very satisfied with it.-Nat Smale, University of Utah I have taught our Foundations of Analysis course (based on Joe Taylor.s book) several times recently, and have enjoyed doing so. The book is well-written, clear, and concise, and supplies the students with very good introductory discussions of the various t

  8. Foundations of stochastic analysis

    CERN Document Server

    Rao, M M; Lukacs, E

    1981-01-01

    Foundations of Stochastic Analysis deals with the foundations of the theory of Kolmogorov and Bochner and its impact on the growth of stochastic analysis. Topics covered range from conditional expectations and probabilities to projective and direct limits, as well as martingales and likelihood ratios. Abstract martingales and their applications are also discussed. Comprised of five chapters, this volume begins with an overview of the basic Kolmogorov-Bochner theorem, followed by a discussion on conditional expectations and probabilities containing several characterizations of operators and mea

  9. Impedance of Bucket Foundations

    DEFF Research Database (Denmark)

    Andersen, Lars; Ibsen, Lars Bo; Liingaard, Morten

    2008-01-01

    Modern offshore wind turbines are flexible structures with natural frequencies near the excitation frequencies related to wave and wind-induced loads. In order to obtain a reliable prediction of the structural response, the dynamic stiffness of the foundation must be evaluated accurately...... solutions, finding that the present boundary-element-finite-element model provides accurate results. The influence of the soil properties as well as the skirt length of the foundation is analysed, and each dynamic stiffness component is computed as function of a non-dimensional frequency....

  10. Transient Monotonic and Cyclic Load Effects on Mono Bucket Foundations

    DEFF Research Database (Denmark)

    Nielsen, Søren Dam

    and when hitting the foundation they induce high impact loads with a short duration. It is important that the foundation is able to resists these huge loads. Fortunately, the conducted research showed that the capacity of the mono bucket foundation is high to impact loads. When exposed to a huge wave load...

  11. Review: Udo Kelle (2007. Die Integration qualitativer und quantitativer Methoden in der empirischen Sozialforschung [Integrating Qualitative and Quantitative Methods in Empirical Social Research: Theoretical Foundations and Methodological Concepts

    Directory of Open Access Journals (Sweden)

    Jeannette Bischkopf

    2008-07-01

    Full Text Available Udo KELLE adds to the debate on integrating qualitative and quantitative methods by going beyond epistemological and pragmatic arguments and placing a stronger emphasis on the area of research and the actual research questions addressed empirically in social science. The fact that social scientific research mainly involves middle-range theories poses specific methodological problems for each of the two research traditions and makes their combination inevitable. The integrative methodological program the author develops can be understood as a new guiding program for evaluating the strengths and weaknesses of qualitative as well as quantitative methods and for deciding in which area of research and for which research questions each methods is best suited. The book provides a wealth of arguments for a theoretical and methodological integration of the two research traditions but these arguments could have been made more accessible by including more examples from actual research projects. URN: urn:nbn:de:0114-fqs080386

  12. Real-Life Solutions to Real-Life Problems: Collaborating with a Non-Profit Foundation to Engage Honors Students in Applied Research

    Science.gov (United States)

    Stark, Emily

    2013-01-01

    Colleges and universities have long emphasized undergraduate research experiences as valuable activities for students. Collegiate honors programs in particular have embraced the role of student research as an integral experience for high-ability students, leading the way in developing the thesis-based model of undergraduate research that is…

  13. Foundation of Basic Arithmetic

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 11; Issue 2. Foundation of Basic Arithmetic. Jasbir S Chahal. General Article Volume 11 Issue 2 February 2006 pp 6-16. Fulltext. Click here to view fulltext PDF. Permanent link: http://www.ias.ac.in/article/fulltext/reso/011/02/0006-0016. Keywords. Different ...

  14. Foundations of Basic Geometry

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 11; Issue 7. Foundations of Basic Geometry. Jasbir S Chahal. General Article Volume 11 Issue 7 July 2006 pp 30-41. Fulltext. Click here to view fulltext PDF. Permanent link: http://www.ias.ac.in/article/fulltext/reso/011/07/0030-0041. Keywords. Area ...

  15. Foundation of Basic Arithmetic

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 11; Issue 1. Foundation of Basic Arithmetic. Jasbir S Chahal. General Article Volume 11 Issue 1 January 2006 pp 8-20. Fulltext. Click here to view fulltext PDF. Permanent link: http://www.ias.ac.in/article/fulltext/reso/011/01/0008-0020. Keywords. Roman ...

  16. Foundations of factor analysis

    CERN Document Server

    Mulaik, Stanley A

    2009-01-01

    Introduction Factor Analysis and Structural Theories Brief History of Factor Analysis as a Linear Model Example of Factor AnalysisMathematical Foundations for Factor Analysis Introduction Scalar AlgebraVectorsMatrix AlgebraDeterminants Treatment of Variables as Vectors Maxima and Minima of FunctionsComposite Variables and Linear Transformations Introduction Composite Variables Unweighted Composite VariablesDifferentially Weighted Composites Matrix EquationsMulti

  17. Journal of Educational Foundations

    African Journals Online (AJOL)

    The Journal of Educational Foundations (JEF) publishes papers from all fields in education. The Editorial Board accepts original, scholarly articles on significant educational issues in Nigeria and Africa. Both empirical and theoretical papers are accepted, although empirical papers are strongly preferred. Papers should ...

  18. [History of the development of radiodiagnosis at the Russian Research Center of Roentgenology and Radiology: on the occasion of the 90th anniversary of its foundation].

    Science.gov (United States)

    Solodkiĭ, V A; Kotliarov, P M; Nudnov, N V

    2014-01-01

    The paper describes the history of the Russian Research Center of Roentgenology and Radiology set up 90 years ago, the main advances of the researchers of the Institute in roentgenology and radiodiagnosis in historical perspective--from the last century up to the present day. It gives a brief list of the most important procedures and publications on radiodiagnosis, which have been developed and published by the Institute's researchers.

  19. Defective lamin A-Rb signaling in Hutchinson-Gilford Progeria Syndrome and reversal by farnesyltransferase inhibition.

    Directory of Open Access Journals (Sweden)

    Jackleen Marji

    Full Text Available Hutchinson-Gilford Progeria Syndrome (HGPS is a rare premature aging disorder caused by a de novo heterozygous point mutation G608G (GGC>GGT within exon 11 of LMNA gene encoding A-type nuclear lamins. This mutation elicits an internal deletion of 50 amino acids in the carboxyl-terminus of prelamin A. The truncated protein, progerin, retains a farnesylated cysteine at its carboxyl terminus, a modification involved in HGPS pathogenesis. Inhibition of protein farnesylation has been shown to improve abnormal nuclear morphology and phenotype in cellular and animal models of HGPS. We analyzed global gene expression changes in fibroblasts from human subjects with HGPS and found that a lamin A-Rb signaling network is a major defective regulatory axis. Treatment of fibroblasts with a protein farnesyltransferase inhibitor reversed the gene expression defects. Our study identifies Rb as a key factor in HGPS pathogenesis and suggests that its modulation could ameliorate premature aging and possibly complications of physiological aging.

  20. A farnesyltransferase inhibitor prevents both the onset and late progression of cardiovascular disease in a progeria mouse model.

    Science.gov (United States)

    Capell, Brian C; Olive, Michelle; Erdos, Michael R; Cao, Kan; Faddah, Dina A; Tavarez, Urraca L; Conneely, Karen N; Qu, Xuan; San, Hong; Ganesh, Santhi K; Chen, Xiaoyan; Avallone, Hedwig; Kolodgie, Frank D; Virmani, Renu; Nabel, Elizabeth G; Collins, Francis S

    2008-10-14

    Hutchinson-Gilford progeria syndrome (HGPS) is the most dramatic form of human premature aging. Death occurs at a mean age of 13 years, usually from heart attack or stroke. Almost all cases of HGPS are caused by a de novo point mutation in the lamin A (LMNA) gene that results in production of a mutant lamin A protein termed progerin. This protein is permanently modified by a lipid farnesyl group, and acts as a dominant negative, disrupting nuclear structure. Treatment with farnesyltransferase inhibitors (FTIs) has been shown to prevent and even reverse this nuclear abnormality in cultured HGPS fibroblasts. We have previously created a mouse model of HGPS that shows progressive loss of vascular smooth muscle cells in the media of the large arteries, in a pattern that is strikingly similar to the cardiovascular disease seen in patients with HGPS. Here we show that the dose-dependent administration of the FTI tipifarnib (R115777, Zarnestra) to this HGPS mouse model can significantly prevent both the onset of the cardiovascular phenotype as well as the late progression of existing cardiovascular disease. These observations provide encouraging evidence for the current clinical trial of FTIs for this rare and devastating disease.

  1. Lifespan extension by dietary intervention in a mouse model of Cockayne syndrome uncouples early postnatal development from segmental progeria.

    Science.gov (United States)

    Brace, Lear E; Vose, Sarah C; Vargas, Dorathy F; Zhao, Shuangyun; Wang, Xiu-Ping; Mitchell, James R

    2013-12-01

    Cockayne syndrome (CS) is a rare autosomal recessive segmental progeria characterized by growth failure, lipodystrophy, neurological abnormalities, and photosensitivity, but without skin cancer predisposition. Cockayne syndrome life expectancy ranges from 5 to 16 years for the two most severe forms (types II and I, respectively). Mouse models of CS have thus far been of limited value due to either very mild phenotypes, or premature death during postnatal development prior to weaning. The cause of death in severe CS models is unknown, but has been attributed to extremely rapid aging. Here, we found that providing mutant pups with soft food from as late as postnatal day 14 allowed survival past weaning with high penetrance independent of dietary macronutrient balance in a novel CS model (Csa(-/-) | Xpa(-/-)). Survival past weaning revealed a number of CS-like symptoms including small size, progressive loss of adiposity, and neurological symptoms, with a maximum lifespan of 19 weeks. Our results caution against interpretation of death before weaning as premature aging, and at the same time provide a valuable new tool for understanding mechanisms of progressive CS-related progeroid symptoms including lipodystrophy and neurodysfunction. © 2013 the Anatomical Society and John Wiley & Sons Ltd.

  2. Chemical screening identifies ROCK as a target for recovering mitochondrial function in Hutchinson-Gilford progeria syndrome.

    Science.gov (United States)

    Kang, Hyun Tae; Park, Joon Tae; Choi, Kobong; Choi, Hyo Jei Claudia; Jung, Chul Won; Kim, Gyu Ree; Lee, Young-Sam; Park, Sang Chul

    2017-06-01

    Hutchinson-Gilford progeria syndrome (HGPS) constitutes a genetic disease wherein an aging phenotype manifests in childhood. Recent studies indicate that reactive oxygen species (ROS) play important roles in HGPS phenotype progression. Thus, pharmacological reduction in ROS levels has been proposed as a potentially effective treatment for patient with this disorder. In this study, we performed high-throughput screening to find compounds that could reduce ROS levels in HGPS fibroblasts and identified rho-associated protein kinase (ROCK) inhibitor (Y-27632) as an effective agent. To elucidate the underlying mechanism of ROCK in regulating ROS levels, we performed a yeast two-hybrid screen and discovered that ROCK1 interacts with Rac1b. ROCK activation phosphorylated Rac1b at Ser71 and increased ROS levels by facilitating the interaction between Rac1b and cytochrome c. Conversely, ROCK inactivation with Y-27632 abolished their interaction, concomitant with ROS reduction. Additionally, ROCK activation resulted in mitochondrial dysfunction, whereas ROCK inactivation with Y-27632 induced the recovery of mitochondrial function. Furthermore, a reduction in the frequency of abnormal nuclear morphology and DNA double-strand breaks was observed along with decreased ROS levels. Thus, our study reveals a novel mechanism through which alleviation of the HGPS phenotype is mediated by the recovery of mitochondrial function upon ROCK inactivation. © 2017 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.

  3. Cyber warfare building the scientific foundation

    CERN Document Server

    Jajodia, Sushil; Subrahmanian, VS; Swarup, Vipin; Wang, Cliff

    2015-01-01

    This book features a wide spectrum of the latest computer science research relating to cyber warfare, including military and policy dimensions. It is the first book to explore the scientific foundation of cyber warfare and features research from the areas of artificial intelligence, game theory, programming languages, graph theory and more. The high-level approach and emphasis on scientific rigor provides insights on ways to improve cyber warfare defense worldwide. Cyber Warfare: Building the Scientific Foundation targets researchers and practitioners working in cyber security, especially gove

  4. At the United Nation Foundation's Social Good Summit, Vice President Biden Announces New Cancer Moonshot International Cooperation and Investments | Office of Cancer Clinical Proteomics Research

    Science.gov (United States)

    This week, Vice President Joe Biden announced progress on his global vision for the Cancer Moonshot.  Announced were 10 new Memoranda of Understanding or Memoranda of Cooperation for international cancer research and care, as well as new efforts in the emerging scientific areas of precision oncology, the funding of collaborative research centers to address cancer disparities in low- and middle- income (LMIC) countries, and a strengthening of existing U.S. bilateral science and technology engagements around cancer.  

  5. Mathematical foundations of neurocomputing

    Energy Technology Data Exchange (ETDEWEB)

    Amari, S. (Tokyo Univ. (Japan). Faculty of Engineering)

    1990-09-01

    Neurocomputing makes use of parallel dynamical interactions of modifiable neuron-like elements. It is important to show, by mathematical treatments, the capabilities and limitations of information processing by various architectures of neural networks. This paper, gives mathematical foundations to neurocomputing. It considers the capabilities of transformations by layered networks, statistical neurodynamics, the dynamical characteristics of associative memory, a general theory of neural learning, and self-organization of neural networks.

  6. Foundations of image science

    CERN Document Server

    Barrett, Harrison H

    2013-01-01

    Winner of the 2006 Joseph W. Goodman Book Writing Award! A comprehensive treatment of the principles, mathematics, and statistics of image science In today's visually oriented society, images play an important role in conveying messages. From seismic imaging to satellite images to medical images, our modern society would be lost without images to enhance our understanding of our health, our culture, and our world. Foundations of Image Science presents a comprehensive treatment of the principles, mathematics, and st

  7. Topological Foundations of Electromagnetism

    CERN Document Server

    Barrett, Terrence W

    2008-01-01

    Topological Foundations of Electromagnetism seeks a fundamental understanding of the dynamics of electromagnetism; and marshals the evidence that in certain precisely defined topological conditions, electromagnetic theory (Maxwell's theory) must be extended or generalized in order to provide an explanation and understanding of, until now, unusual electromagnetic phenomena. Key to this generalization is an understanding of the circumstances under which the so-called A potential fields have physical effects. Basic to the approach taken is that the topological composition of electromagnetic field

  8. CONVEYOR FOUNDATIONS CALCULATION

    Energy Technology Data Exchange (ETDEWEB)

    S. Romanos

    1995-03-10

    The purpose of these calculations is to design foundations for all conveyor supports for the surface conveyors that transport the muck resulting from the TBM operation, from the belt storage to the muck stockpile. These conveyors consist of: (1) Conveyor W-TO3, from the belt storage, at the starter tunnel, to the transfer tower. (2) Conveyor W-SO1, from the transfer tower to the material stacker, at the muck stockpile.

  9. Research Briefings 1986. For the Office of Science and Technology Policy, the National Science Foundation, and Selected Federal Departments and Agencies.

    Science.gov (United States)

    National Academy of Sciences, Washington, DC.

    This is part of a series on selected areas of science and technology prepared by the Committee on Science, Engineering, and Public Policy, at the request of the Science Advisor to the President of the United States. This volume includes four individual reports. The first is the report of the "Research Briefing Panel on Science of Interfaces…

  10. The Language of Media and the Cultivation of Mental Skills. A Report on Three Years of Research Submitted to the Spencer Foundation.

    Science.gov (United States)

    Salomon, Gavriel

    This report presents two research studies. The first, an experiment using 176 fifth graders, tested three hypotheses: (1) When content is held constant across messages, different formats of a medium differentially call for mental skills. (2) Formats which call for the same skills in different ways affect learners differently. (3) The TV formats…

  11. Emotional foundations of cognitive control.

    Science.gov (United States)

    Inzlicht, Michael; Bartholow, Bruce D; Hirsh, Jacob B

    2015-03-01

    Often seen as the paragon of higher cognition, here we suggest that cognitive control is dependent on emotion. Rather than asking whether control is influenced by emotion, we ask whether control itself can be understood as an emotional process. Reviewing converging evidence from cybernetics, animal research, cognitive neuroscience, and social and personality psychology, we suggest that cognitive control is initiated when goal conflicts evoke phasic changes to emotional primitives that both focus attention on the presence of goal conflicts and energize conflict resolution to support goal-directed behavior. Critically, we propose that emotion is not an inert byproduct of conflict but is instrumental in recruiting control. Appreciating the emotional foundations of control leads to testable predictions that can spur future research. Copyright © 2015 Elsevier Ltd. All rights reserved.

  12. Foundations for microstrip circuit design

    CERN Document Server

    Edwards, Terry

    2016-01-01

    Building on the success of the previous three editions, Foundations for Microstrip Circuit Design offers extensive new, updated and revised material based upon the latest research. Strongly design-oriented, this fourth edition provides the reader with a fundamental understanding of this fast expanding field making it a definitive source for professional engineers and researchers and an indispensable reference for senior students in electronic engineering. Topics new to this edition: microwave substrates, multilayer transmission line structures, modern EM tools and techniques, microstrip and planar transmision line design, transmission line theory, substrates for planar transmission lines, Vias, wirebonds, 3D integrated interposer structures, computer-aided design, microstrip and power-dependent effects, circuit models, microwave network analysis, microstrip passive elements, and slotline design fundamentals.

  13. A review of the theoretical foundations of research into arts-based interventions in organisations and management education, and their methodological implications

    OpenAIRE

    Kernan, M.A.

    2014-01-01

    This paper explores theoretical frameworks, drawn primarily from learning theory, which might inform future research into arts-based initiatives (ABIs) in organisations and HE, and both the analysis and of outcomes.\\ud The theoretical insights considered here include pedagogical and philosophical models (eg Buber 1937/2002; Heron 1992; and Gardner 2006, 2011); psychological and management frameworks in self-efficacy, social cognition, socio-constructive approaches and complexity theory (eg Ba...

  14. Networking and Information Technology Research and Development. Advanced Foundations for American Innovation. Supplement to the President’s FY 2004 Budget

    Science.gov (United States)

    2003-09-01

    Atlantic Monthly article proposing “ Memex ,” a configurable device for information storage and retrieval g) Thomas Edison films in Open Video Project include...NIST, and NSF, this free interactive resource – accessed some 50 million times in 2002 – enables researchers to find and download validated structural...log on to www.SATshot.com, where they download the free AI/Satshot Viewer, based on NASA imaging software customized by the farmer and university

  15. Scour around Offshore Windturbine Foundations

    DEFF Research Database (Denmark)

    Larsen, Brian Juul; De Vos, Leen; Frigaard, Peter

    For the present report a testprogramme has been performed to determine the scour around offshore windturbine foundations.......For the present report a testprogramme has been performed to determine the scour around offshore windturbine foundations....

  16. Instant Zurb Foundation 4

    CERN Document Server

    Arévalo, Jorge

    2013-01-01

    A quick and easy guide that follows a practical approach to rapidly create responsive web pages using Foundation 4 framework, following the mobile-first philosophy.If you are a web developer who wants to get the most out of your HTML5/CSS/JavaScript skills, this book is ideal for you. It is assumed that you will have some experience with these languages, but for those who don't, you can also be up and running in an instant.

  17. Mathematical foundations of elasticity

    CERN Document Server

    Marsden, Jerrold E

    1994-01-01

    This advanced-level study approaches mathematical foundations of three-dimensional elasticity using modern differential geometry and functional analysis. It is directed to mathematicians, engineers and physicists who wish to see this classical subject in a modern setting with examples of newer mathematical contributions. Prerequisites include a solid background in advanced calculus and the basics of geometry and functional analysis.The first two chapters cover the background geometry ― developed as needed ― and use this discussion to obtain the basic results on kinematics and dynamics of con

  18. Geometric and numerical foundations of movements

    CERN Document Server

    Mansard, Nicolas; Lasserre, Jean-Bernard

    2017-01-01

    This book aims at gathering roboticists, control theorists, neuroscientists, and mathematicians, in order to promote a multidisciplinary research on movement analysis. It follows the workshop “ Geometric and Numerical Foundations of Movements ” held at LAAS-CNRS in Toulouse in November 2015[1]. Its objective is to lay the foundations for a mutual understanding that is essential for synergetic development in motion research. In particular, the book promotes applications to robotics --and control in general-- of new optimization techniques based on recent results from real algebraic geometry.

  19. American foundations : roles and contributions

    OpenAIRE

    Anheier, Helmut K.; Hammack, David

    2010-01-01

    Foundations play an essential part in the philanthropic activity that defines so much of American life. No other nation provides its foundations with so much autonomy and freedom of action as does the United States. Liberated both from the daily discipline of the market and from direct control by government, American foundations understandably attract great attention. As David Hammack and Helmut Anheier note in this volume, "Americans have criticized foundations for... their alleged conservat...

  20. Wave Forces on Windturbine Foundations

    DEFF Research Database (Denmark)

    Larsen, Brian Juul; Frigaard, Peter

    A testprogramme has been performed to determine the wave forces on two types of foundations for an offshore windturbine. the tested foundation types are a monopile and cone. Furthermore the shaft of the cone has been tested.......A testprogramme has been performed to determine the wave forces on two types of foundations for an offshore windturbine. the tested foundation types are a monopile and cone. Furthermore the shaft of the cone has been tested....

  1. The moral foundations of illusory correlation.

    Science.gov (United States)

    Rodríguez-Ferreiro, Javier; Barberia, Itxaso

    2017-01-01

    Previous research has studied the relationship between political ideology and cognitive biases, such as the tendency of conservatives to form stronger illusory correlations between negative infrequent behaviors and minority groups. We further explored these findings by studying the relation between illusory correlation and moral values. According to the moral foundations theory, liberals and conservatives differ in the relevance they concede to different moral dimensions: Care, Fairness, Loyalty, Authority, and Purity. Whereas liberals consistently endorse the Care and Fairness foundations more than the Loyalty, Authority and Purity foundations, conservatives tend to adhere to the five foundations alike. In the present study, a group of participants took part in a standard illusory correlation task in which they were presented with randomly ordered descriptions of either desirable or undesirable behaviors attributed to individuals belonging to numerically different majority and minority groups. Although the proportion of desirable and undesirable behaviors was the same in the two groups, participants attributed a higher frequency of undesirable behaviors to the minority group, thus showing the expected illusory correlation effect. Moreover, this effect was specifically associated to our participants' scores in the Loyalty subscale of the Moral Foundations Questionnaire. These results emphasize the role of the Loyalty moral foundation in the formation of attitudes towards minorities among conservatives. Our study points out the moral system as a useful fine-grained framework to explore the complex interaction between basic cognitive processes and ideology.

  2. The moral foundations of illusory correlation

    Science.gov (United States)

    Barberia, Itxaso

    2017-01-01

    Previous research has studied the relationship between political ideology and cognitive biases, such as the tendency of conservatives to form stronger illusory correlations between negative infrequent behaviors and minority groups. We further explored these findings by studying the relation between illusory correlation and moral values. According to the moral foundations theory, liberals and conservatives differ in the relevance they concede to different moral dimensions: Care, Fairness, Loyalty, Authority, and Purity. Whereas liberals consistently endorse the Care and Fairness foundations more than the Loyalty, Authority and Purity foundations, conservatives tend to adhere to the five foundations alike. In the present study, a group of participants took part in a standard illusory correlation task in which they were presented with randomly ordered descriptions of either desirable or undesirable behaviors attributed to individuals belonging to numerically different majority and minority groups. Although the proportion of desirable and undesirable behaviors was the same in the two groups, participants attributed a higher frequency of undesirable behaviors to the minority group, thus showing the expected illusory correlation effect. Moreover, this effect was specifically associated to our participants’ scores in the Loyalty subscale of the Moral Foundations Questionnaire. These results emphasize the role of the Loyalty moral foundation in the formation of attitudes towards minorities among conservatives. Our study points out the moral system as a useful fine-grained framework to explore the complex interaction between basic cognitive processes and ideology. PMID:28972990

  3. Problem solving in foundation engineering using foundationPro

    CERN Document Server

    Yamin, Mohammad

    2016-01-01

    This book is at once a supplement to traditional foundation engineering textbooks and an independent problem-solving learning tool. The book is written primarily for university students majoring in civil or construction engineering taking foundation analysis and design courses to encourage them to solve design problems. Its main aim is to stimulate problem solving capability and foster self-directed learning. It also explains the use of the foundationPro software, available at no cost, and includes a set of foundation engineering applications. Taking a unique approach, Dr. Yamin summarizes the general step-by-step procedure to solve various foundation engineering problems, illustrates traditional applications of these steps with longhand solutions, and presents the foundationPro solutions. The special structure of the book allows it to be used in undergraduate and graduate foundation design and analysis courses in civil and construction engineering. The book stands as valuable resource for students, faculty, ...

  4. The Impact of an Interactive Statistics Module on Novices' Development of Scientific Process Skills and Attitudes in a First-Semester Research Foundations Course.

    Science.gov (United States)

    Marsan, Lynnsay A; D'Arcy, Christina E; Olimpo, Jeffrey T

    2016-12-01

    Evidence suggests that incorporating quantitative reasoning exercises into existent curricular frameworks within the science, technology, engineering, and mathematics (STEM) disciplines is essential for novices' development of conceptual understanding and process skills in these domains. Despite this being the case, such studies acknowledge that students often experience difficulty in applying mathematics in the context of scientific problems. To address this concern, the present study sought to explore the impact of active demonstrations and critical reading exercises on novices' comprehension of basic statistical concepts, including hypothesis testing, experimental design, and interpretation of research findings. Students first engaged in a highly interactive height activity that served to intuitively illustrate normal distribution, mean, standard deviation, and sample selection criteria. To enforce practical applications of standard deviation and p-value, student teams were subsequently assigned a figure from a peer-reviewed primary research article and instructed to evaluate the trustworthiness of the data. At the conclusion of this exercise, students presented their evaluations to the class for open discussion and commentary. Quantitative assessment of pre- and post-module survey data indicated a statistically significant increase both in students' scientific reasoning and process skills and in their self-reported confidence in understanding the statistical concepts presented in the module. Furthermore, data indicated that the majority of students (>85%) found the module both interesting and helpful in nature. Future studies will seek to develop additional, novel exercises within this area and to evaluate the impact of such modules across a variety of STEM and non-STEM contexts.

  5. [Foundation of the science and society alliance in France. Towards a conscious and recognised collaboration between actors of research and civil society].

    Science.gov (United States)

    Fellini, Nadia; Faroult, Elie

    2015-01-01

    In the last two decades, the debate on the meaning of science in relation to societies that create it, nourish it, and benefit from it, focused on civil society's ability to produce knowledge. This yielded first the concept of participatory science and later the wider concept of participatory research. Throughout Europe, numerous collective experimentations have generated countless interactions, and new interfaces between the world of research and civil society are constantly being created. But in spite of the proliferation of these experiences, a paradox slows down their acknowledgment and legitimation. On the one hand, these interactions often go unseen and unrecognized by the institutions, public policies, and even at times their very creators. On the other hand, scientists, are still overwhelmingly wary of civil society and, perceiving only its intellectual deficit and lack of comprehension, they fail to consider the study and development of these interactions as being of primary importance. The Sciences and Society Alliance, which was recently founded in France, provides a platform where these collaborative experiences can be collected, studied, supported, communicated, and institutionally acknowledged. The launch of this process,which is soon to be European in scope, answers the need to bring science into the democratic path tread by the societies that create it. In its ability to compose diversity, this process is an example of deep democracy.

  6. Foundations for offshore wind turbines.

    Science.gov (United States)

    Byrne, B W; Houlsby, G T

    2003-12-15

    An important engineering challenge of today, and a vital one for the future, is to develop and harvest alternative sources of energy. This is a firm priority in the UK, with the government setting a target of 10% of electricity from renewable sources by 2010. A component central to this commitment will be to harvest electrical power from the vast energy reserves offshore, through wind turbines or current or wave power generators. The most mature of these technologies is that of wind, as much technology transfer can be gained from onshore experience. Onshore wind farms, although supplying 'green energy', tend to provoke some objections on aesthetic grounds. These objections can be countered by locating the turbines offshore, where it will also be possible to install larger capacity turbines, thus maximizing the potential of each wind farm location. This paper explores some civil-engineering problems encountered for offshore wind turbines. A critical component is the connection of the structure to the ground, and in particular how the load applied to the structure is transferred safely to the surrounding soil. We review previous work on the design of offshore foundations, and then present some simple design calculations for sizing foundations and structures appropriate to the wind-turbine problem. We examine the deficiencies in the current design approaches, and the research currently under way to overcome these deficiencies. Designs must be improved so that these alternative energy sources can compete economically with traditional energy suppliers.

  7. Mathematical foundations of biomechanics.

    Science.gov (United States)

    Niederer, Peter F

    2010-01-01

    The aim of biomechanics is the analysis of the structure and function of humans, animals, and plants by means of the methods of mechanics. Its foundations are in particular embedded in mathematics, physics, and informatics. Due to the inherent multidisciplinary character deriving from its aim, biomechanics has numerous connections and overlapping areas with biology, biochemistry, physiology, and pathophysiology, along with clinical medicine, so its range is enormously wide. This treatise is mainly meant to serve as an introduction and overview for readers and students who intend to acquire a basic understanding of the mathematical principles and mechanics that constitute the foundation of biomechanics; accordingly, its contents are limited to basic theoretical principles of general validity and long-range significance. Selected examples are included that are representative for the problems treated in biomechanics. Although ultimate mathematical generality is not in the foreground, an attempt is made to derive the theory from basic principles. A concise and systematic formulation is thereby intended with the aim that the reader is provided with a working knowledge. It is assumed that he or she is familiar with the principles of calculus, vector analysis, and linear algebra.

  8. The Impact of an Interactive Statistics Module on Novices’ Development of Scientific Process Skills and Attitudes in a First-Semester Research Foundations Course

    Directory of Open Access Journals (Sweden)

    Lynnsay A. Marsan

    2016-12-01

    Full Text Available Evidence suggests that incorporating quantitative reasoning exercises into existent curricular frameworks within the science, technology, engineering, and mathematics (STEM disciplines is essential for novices’ development of conceptual understanding and process skills in these domains. Despite this being the case, such studies acknowledge that students often experience difficulty in applying mathematics in the context of scientific problems. To address this concern, the present study sought to explore the impact of active demonstrations and critical reading exercises on novices’ comprehension of basic statistical concepts, including hypothesis testing, experimental design, and interpretation of research findings. Students first engaged in a highly interactive height activity that served to intuitively illustrate normal distribution, mean, standard deviation, and sample selection criteria. To enforce practical applications of standard deviation and p-value, student teams were subsequently assigned a figure from a peer-reviewed primary research article and instructed to evaluate the trustworthiness of the data. At the conclusion of this exercise, students presented their evaluations to the class for open discussion and commentary. Quantitative assessment of pre- and post-module survey data indicated a statistically significant increase both in students’ scientific reasoning and process skills and in their self-reported confidence in understanding the statistical concepts presented in the module. Furthermore, data indicated that the majority of students (>85% found the module both interesting and helpful in nature. Future studies will seek to develop additional, novel exercises within this area and to evaluate the impact of such modules across a variety of STEM and non-STEM contexts.

  9. Developing a Child and Youth Mental Health and Addictions Framework for Yukon as a Foundation for Policy Reform: Engaging Stakeholders Through a Policy and Research Partnership

    Directory of Open Access Journals (Sweden)

    Gillian Mulvale

    2016-09-01

    Full Text Available In April 2015 the Yukon Government released a new child and youth mental health and addictions framework (CYMHAF to improve territory-wide access to basic mental health care and coordination of services for children and families. Yukon’s limited resource base and dispersed population challenges delivery of child and youth mental health and addictions services to small rural communities where needs are often high as a legacy of residential school policies. The objective of CYMHAF is to improve outcomes by identifying and capitalizing on current strengths, and reallocating existing resources to better meet the mental health needs of Yukon youth and families. Access, coordination and quality problems associated with existing services, growing public awareness of mental health issues, and a new national policy framework designed to assist provinces and territories, led Yukon policy makers to partner with researchers to capitalize on a Canadian Institutes of Health Research (CIHR strategic grant initiative. CYMHAF was based on extensive stakeholder engagement, best evidence and advice from key informants in other jurisdictions, and offers a cascading model of service delivery through which basic mental health care can be provided by existing health and human service workers in communities. These workers will be trained in child and youth mental health competencies, and will have electronic linkages and support to integrated teams of primary care providers who will be located in regional hubs once fully implemented, and to specialists in Whitehorse and out of Territory. Implementation is underway with some training of front line Health and Social Service and First Nations workers, a new mental wellness strategy for Yukon founded on CYMHAF scheduled for release in spring 2016, and may be accelerated by federal government promises of a new Health Accord and a new relationship with indigenous people.

  10. Challenges and Ideas to Achieve Wireless 100 Gb/s Transmission: An Overview of Challenges and Solutions within the German Research Foundation (DFG) Special Priority Program SPP1655

    Science.gov (United States)

    Kraemer, Rolf

    2017-09-01

    Wireless communications is one of the fastest growing technology fields, driving numerous other innovations in electronics. One challenging research area within the wireless field is to achieve much higher transmission rates. First products with up to 3 Gb/s are in the market. In the coming years we predict this speed growing quickly up to and beyond 100 Gb/s. Today it is an open question how we can realize a wireless system at this speed. If we intend to use such systems in a mobile environment, we can only afford to spend approximately 1-10 pW/b for the end-to-end communication. This includes RF-transmission and all processing and protocol steps. The SPP1655 of the DFG was set up to investigate new paradigms for achieving the 100 Gb/s wireless transmission goal. Within 11 coordinated projects researchers from all over Germany are addressing several relevant issues ranging from the antennas and RF-Frontend, baseband-processing and error correction to protocol processing. A number of limitations of current approaches have to be investigated and new algorithms must be found in order to achieve the intended goal. One of the big challenges is finding the correct balance between analog and digital signal processing to achieve an extremely high performance at very low energy consumption. Another challenge is to find a good balance between bandwidth and bandwidth efficiency to achieve the 100 Gbps goal. Finally, protocol processing will need new approaches to decouple the central processor of a computer from the high-end input/output operations. Within this editorial we will address the main challenges and briefly outline the approaches of the running projects. The rest of this special issue will be devoted to more detailed descriptions and achievements of the individual projects of SPP1655.

  11. Activities of the National Academy of Sciences in relation to the Radiation Effects Research Foundation. Annual performance report, June 1, 1991--May 31, 1992

    Energy Technology Data Exchange (ETDEWEB)

    Edington, C.W.

    1992-06-01

    This progress report relates progress in the various research projects evaluating the late health effects, both somatic and genetic, resulting from radiation exposure of the survivors of the atomic bombs at Hiroshima and Nagasaki, Japan. Considerable progress has been made in the collection and utilization of the various epidemiological data bases. These include the Life Span Study, (LSS) cohort, the Adult Health Study (AHS) cohort, the In Utero cohort, the leukemia registry and the F-1 Study population. Important progress has been made in using RERF Tumor and Tissue Registry records for evaluation of cancer incidence and radiation risk estimates for comparison with cancer mortality and risk in the LSS cohort. At the present time, a manuscript on the incidence of solid tumors (1950-1987) is undergoing internal and external review for publication as an RERF Technical report (TR) and for publication in a peer-reviewed scientific journal. In addition, manuscripts are in preparation on (1) a comprehensive report on the incidence of hematological cancers, including analysis of leukemia by cell type (1950-1987), (2) a general description of Tumor Registry operations and (3) a comparison of incidence- and mortality-based estimates of radiation risk in the LSS cohort.

  12. Static Behaviour of Bucket Foundations

    DEFF Research Database (Denmark)

    Larsen, Kim André

    as well as large-scale tests on bucket foundations subjected to low vertical load are performed during this work. Numerical simulations of the tests performed are carried out using the Mohr Coulomb material model and the commercial finite element code ABAQUS. Based on the present work, the finite element......One new foundation concept in relation to offshore wind turbines is bucket foundations. The concept is known from the oil and gas industry, though the load conditions here are significantly different. The bucket foundation can be used as monopod or e.g. tripod foundations for offshore wind turbines....... The monopod concept is investigated in this thesis, regarding the static behaviour from loads relevant to offshore wind turbines. The main issue in this concept is the rotational stiffness of the foundation and the combined capacity dominated by moments. The vertical bearing capacity of bucket foundations...

  13. Foundations of Power

    DEFF Research Database (Denmark)

    Lev, Amnon

    of state power. This sets the modern state apart from the societies of the Middle Ages in which civil authority was either seen to be founded in religion (Christian doctrine) or in custom (Roman law). In the age of the modern state, it is law, or rather, constitutional doctrine that serves as the medium...... in which human freedom is translated into civil authority. The system of this translation is natural law.   The dissertation traces the genesis and the disintegration of the tradition of modern natural law in the period from the 17th to the 19th century. It shows how the format of 20th century......The categories of law play an essential part in the elaboration of the concept of the modern state. From the 17th century society is perceived to be the product of the free will of its citizens, as expressed in their consent to the social contract. Contract thus becomes the conceptual foundation...

  14. Foundations of signal processing

    CERN Document Server

    Vetterli, Martin; Goyal, Vivek K

    2014-01-01

    This comprehensive and engaging textbook introduces the basic principles and techniques of signal processing, from the fundamental ideas of signals and systems theory to real-world applications. Students are introduced to the powerful foundations of modern signal processing, including the basic geometry of Hilbert space, the mathematics of Fourier transforms, and essentials of sampling, interpolation, approximation and compression. The authors discuss real-world issues and hurdles to using these tools, and ways of adapting them to overcome problems of finiteness and localisation, the limitations of uncertainty and computational costs. Standard engineering notation is used throughout, making mathematical examples easy for students to follow, understand and apply. It includes over 150 homework problems and over 180 worked examples, specifically designed to test and expand students' understanding of the fundamentals of signal processing, and is accompanied by extensive online materials designed to aid learning, ...

  15. Mathematical foundation of quantum mechanics

    CERN Document Server

    Parthasarathy, K R

    2005-01-01

    This is a brief introduction to the mathematical foundations of quantum mechanics based on lectures given by the author to Ph.D.students at the Delhi Centre of the Indian Statistical Institute in order to initiate active research in the emerging field of quantum probability. The material in the first chapter is included in the author's book "An Introduction to Quantum Stochastic Calculus" published by Birkhauser Verlag in 1992 and the permission of the publishers to reprint it here is acknowledged. Apart from quantum probability, an understanding of the role of group representations in the development of quantum mechanics is always a fascinating theme for mathematicians. The first chapter deals with the definitions of states, observables and automorphisms of a quantum system through Gleason's theorem, Hahn-Hellinger theorem and Wigner's theorem. Mackey's imprimitivity theorem and the theorem of inducing representations of groups in stages are proved directly for projective unitary antiunitary representations ...

  16. Sir Henry Solomon Wellcome and Dr Andrew Balfour: an enterprise on the Nile and the early foundation of public health and medical research in the Sudan (1899-1935).

    Science.gov (United States)

    Elhadd, T A

    2015-01-01

    In Sudan, modern medical practice and medical research began soon after the creation of Anglo-Egyptian Sudan at the turn of the 20th century. The benevolent involvement of Sir Henry Solomon Wellcome, and the ingenious feat of his protégé Sir Andrew Balfour, was crucial to the strong foundation of that establishment. Sir Henry Wellcome provided the financial sponsorship plus influential, logistical and moral support. Dr Balfour put great energy into making the enterprise one of the most amazing medical achievements in colonial medicine. Improvement in the public health of the capital Khartoum was emulated by other doctors working in this vast country. Research was not restricted to tropical medicine; it also encompassed agricultural and chemical research. This helped with the establishment of the first modern medical school in the country in 1924 and resulted in the medical service in Sudan being described as one of the best in the world. Many British doctors flocked to Sudan to make a fortune and to set a path for their career back in Britain.

  17. Israel Science Foundation | IDRC - International Development ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Israel Science Foundation. https://www.isf.org.il/#/ · What we do · Funding · Resources · About IDRC. Knowledge. Innovation. Solutions. Careers · Contact Us · Site map. Sign up now for IDRC news and views sent directly to your inbox each month. Subscribe · Copyright · Open access policy · Privacy policy · Research ethics ...

  18. 76 FR 7855 - Patient Safety Organizations: Voluntary Delisting From Community Medical Foundation for Patient...

    Science.gov (United States)

    2011-02-11

    ... HUMAN SERVICES Agency for Healthcare Research and Quality Patient Safety Organizations: Voluntary Delisting From Community Medical Foundation for Patient Safety AGENCY: Agency for Healthcare Research and Quality (AHRQ), HHS. ACTION: Notice of Delisting. SUMMARY: Community Medical Foundation for Patient Safety...

  19. Governance of Open Source Software Foundations: Who Holds the Power?

    Directory of Open Access Journals (Sweden)

    Ludovico Prattico

    2012-12-01

    Full Text Available The research reported in this article attempts to discover who holds the power in open source software foundations through the analysis of governance documents. Artificial neural network analysis is used to analyse the content of the bylaws of six open source foundations (Apache, Eclipse, GNOME, Plone, Python, and SPI for the purpose of identifying power structures. Results of the research suggest that: i the actions of an open source software foundation are centered around one of three groups: Members, Chairman/President/Executive Director, and Board of Directors; ii in only one of the six foundations is the Board of Directors responsible for both the community and the product; and iii artificial neural network analysis of the content of bylaws provides unbiased insights of the power structure of open source software foundations. These results may prove useful to those who contribute to open source foundations and use their products and services.

  20. History on foundation of Korea nuclear power

    Energy Technology Data Exchange (ETDEWEB)

    Park, Ik Su

    1999-12-15

    This reports the history on foundation of Korea nuclear power from 1955 to 1980, which is divided ten chapters. The contents of this book are domestic and foreign affairs before foundation of nuclear power center, establishment of nuclear power and research center, early activity and internal conflict about nuclear power center, study for nuclear power business and commercialization of the studying ordeal over nuclear power administration and new phase, dispute for jurisdiction on nuclear power business and the process, permission for nuclear reactor, regulation and local administration, the process of deliberation and decision of reactor 3. 4 in Yonggwang, introduction of nuclear reprocessing facilities and activities for social organization.

  1. Foundation Fighting Blindness

    Science.gov (United States)

    ... Media VISIONS Conference Audio/Video Recordings For Researchers & Industry Funding Philosophy Funded Grants & Researchers Apply for Funding ... will be held at the Sheraton San Diego Hotel and Marina, San Diego, California, June 21 – 23, ...

  2. Mortality of people with chronic fatigue syndrome: a retrospective cohort study in England and Wales from the South London and Maudsley NHS Foundation Trust Biomedical Research Centre (SLaM BRC) Clinical Record Interactive Search (CRIS) Register.

    Science.gov (United States)

    Roberts, Emmert; Wessely, Simon; Chalder, Trudie; Chang, Chin-Kuo; Hotopf, Matthew

    2016-04-16

    Mortality associated with chronic fatigue syndrome is uncertain. We investigated mortality in individuals diagnosed with chronic fatigue syndrome in secondary and tertiary care using data from the South London and Maudsley NHS Foundation Trust Biomedical Research Centre (SLaM BRC) Clinical Record Interactive Search (CRIS) register. We calculated standardised mortality ratios (SMRs) for all-cause, suicide-specific, and cancer-specific mortality for a 7-year observation period using the number of deaths observed in SLaM records compared with age-specific and sex-specific mortality statistics for England and Wales. Study participants were included if they had had contact with the chronic fatigue service (referral, discharge, or case note entry) and received a diagnosis of chronic fatigue syndrome. We identified 2147 cases of chronic fatigue syndrome from CRIS and 17 deaths from Jan 1, 2007, to Dec 31, 2013. 1533 patients were women of whom 11 died, and 614 were men of whom six died. There was no significant difference in age-standardised and sex-standardised mortality ratios (SMRs) for all-cause mortality (SMR 1·14, 95% CI 0·65-1·85; p=0·67) or cancer-specific mortality (1·39, 0·60-2·73; p=0·45) in patients with chronic fatigue syndrome when compared with the general population in England and Wales. This remained the case when deaths from suicide were removed from the analysis. There was a significant increase in suicide-specific mortality (SMR 6·85, 95% CI 2·22-15·98; p=0·002). We did not note increased all-cause mortality in people with chronic fatigue syndrome, but our findings show a substantial increase in mortality from suicide. This highlights the need for clinicians to be aware of the increased risk of completed suicide and to assess suicidality adequately in patients with chronic fatigue syndrome. National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London

  3. Lupus Foundation of America

    Science.gov (United States)

    ... Store Read About Our $3.8M Commitment to Stem Cell Research. Learn More Committed to Advancing Research on Lupus ... person with lupus? Get Answers Latest News & Stories Research News | Nov. 16, 2017 Major Lupus Stem Cell Study Receives Funding $3.8 million committed by ...

  4. Foundations of intervention research in instrumental practice

    OpenAIRE

    Hatfield, Johannes Lunde; Lemyre, Nicolas

    2016-01-01

    Copyright © 2016 Hatfield and Lemyre. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms The goals of the presen...

  5. Western Kentucky University Research Foundation Biodiesel Project

    Energy Technology Data Exchange (ETDEWEB)

    Pan, Wei-Ping [Principal Investigator; Cao, Yan [Co-Principal Investigator

    2013-03-15

    Petroleum-based liquid hydrocarbons is exclusively major energy source in the transportation sector. Thus, it is the major CO{sub 2} source which is the associated with greenhouse effect. In the United States alone, petroleum consumption in the transportation sector approaches 13.8 million barrels per day (Mbbl/d). It is corresponding to a release of 0.53 gigatons of carbon per year (GtC/yr), which accounts for approximate 7.6 % of the current global release of CO{sub 2} from all of the fossil fuel usage (7 GtC/yr). For the long term, the conventional petroleum production is predicted to peak in as little as the next 10 years to as high as the next 50 years. Negative environmental consequences, the frequently roaring petroleum prices, increasing petroleum utilization and concerns about competitive supplies of petroleum have driven dramatic interest in producing alternative transportation fuels, such as electricity-based, hydrogen-based and bio-based transportation alternative fuels. Use of either of electricity-based or hydrogen-based alternative energy in the transportation sector is currently laden with technical and economical challenges. The current energy density of commercial batteries is 175 Wh/kg of battery. At a storage pressure of 680 atm, the lower heating value (LHV) of H{sub 2} is 1.32 kWh/liter. In contrast, the corresponding energy density for gasoline can reach as high as 8.88 kWh/liter. Furthermore, the convenience of using a liquid hydrocarbon fuel through the existing infrastructures is a big deterrent to replacement by both batteries and hydrogen. Biomass-derived ethanol and bio-diesel (biofuels) can be two promising and predominant U.S. alternative transportation fuels. Both their energy densities and physical properties are comparable to their relatives of petroleum-based gasoline and diesel, however, biofuels are significantly environmental-benign. Ethanol can be made from the sugar-based or starch-based biomass materials, which is easily fermented to create ethanol. In the United States almost all starch ethanol is mainly manufactured from corn grains. The technology for manufacturing corn ethanol can be considered mature as of the late 1980s. In 2005, 14.3 % of the U.S. corn harvest was processed to produce 1.48 x10{sup 10} liters of ethanol, energetically equivalent to 1.72 % of U.S. gasoline usage. Soybean oil is extracted from 1.5 % of the U.S. soybean harvest to produce 2.56 x 10{sup 8} liters of bio-diesel, which was 0.09 % of U.S. diesel usage. However, reaching maximum rates of bio-fuel supply from corn and soybeans is unlikely because these crops are presently major contributors to human food supplies through livestock feed and direct consumption. Moreover, there currently arguments on that the conversion of many types of many natural landscapes to grow corn for feedstock is likely to create substantial carbon emissions that will exacerbate globe warming. On the other hand, there is a large underutilized resource of cellulose biomass from trees, grasses, and nonedible parts of crops that could serve as a feedstock. One of the potentially significant new bio-fuels is so called "cellulosic ethanol", which is dependent on break-down by microbes or enzymes. Because of technological limitations (the wider variety of molecular structures in cellulose and hemicellulose requires a wider variety of microorganisms to break them down) and other cost hurdles (such as lower kinetics), cellulosic ethanol can currently remain in lab scales. Considering farm yields, commodity and fuel prices, farm energy and agrichemical inputs, production plant efficiencies, byproduct production, greenhouse gas (GHG) emissions, and other environmental effects, a life-cycle evaluation of competitive indicated that corn ethanol yields 25 % more energy than the energy invested in its production, whereas soybean bio-diesel yields 93 % more. Relative to the fossil fuels they displace, greenhouse gas emissions are reduced 12 % by the production and combustion of ethanol and 41 % by bio-diesel. Bio-diesel also releases less air pollutants per net energy gain than ethanol. Bio-diesel has advantages over ethanol due to its lower agricultural inputs and more efficient conversion. Thus, to be a viable alternative, a bio-fuel firstly should be producible in large quantities without reducing food supplies. In this aspect, larger quantity supplies of cellulose biomass are likely viable alternatives. U. S. Congress has introduced an initiative and subsequently rolled into the basic energy package, which encourages the production of fuel from purely renewable resources, biomass. Secondly, a bio-fuel should also provide a net energy gain, have environmental benefits and be economically competitive. In this aspect, bio-diesel has advantages over ethanol. The commonwealth of Kentucky is fortunate to have a diverse and abundant supply of renewable energy resources. Both Kentucky Governor Beshear in the energy plan for Kentucky "Intelligent Energy Choices for Kentucky's Future", and Kentucky Renewable Energy Consortium, outlined strategies on developing energy in renewable, sustainable and efficient ways. Smart utilization of diversified renewable energy resources using advanced technologies developed by Kentucky public universities, and promotion of these technologies to the market place by collaboration between universities and private industry, are specially encouraged. Thus, the initially question answering Governor's strategic plan is if there is any economical way to make utilization of larger quantities of cellulose and hemicellulose for production of bio-fuels, especially bio-diesel. There are some possible options of commercially available technologies to convert cellulose based biomass energy to bio-fuels. Cellulose based biomass can be firstly gasified to obtain synthesis gas (a mixture of CO and H{sub 2}), which is followed up by being converted into liquid hydrocarbon fuels or oxygenate hydrocarbon fuel through Fischer-Tropsch (F-T) synthesis. Methanol production is regarded to be the most economic starting step in many-year practices of the development of F-T synthesis technology since only C{sub 1} synthesis through F-T process can potentially achieve 100% conversion efficiency. Mobil's F-T synthesis process is based on this understanding. Considering the economical advantages of bio-diesel production over ethanol and necessary supply of methanol during bio-diesel production, a new opportunity for bio-diesel production with total supplies of biomass-based raw materials through more economic reaction pathways is likely identified in this proposal. The bio-oil part of biomass can be transesterified under available methanol (or mixed alcohols), which can be synthesized in the most easy part of F-T synthesis process using synthesis gas from gasification of cellulose fractions of biomass. We propose a novel concept to make sense of bio-diesel production economically though a coupling reaction of bio-oil transesterification and methanol synthesis. It will overcome problems of current bio-diesel producing process based on separated handling of methanol and bio-oil.

  6. Michael J. Fox Foundation for Parkinson's Research

    Science.gov (United States)

    ... 2014 2015 2016 Our single, urgent goal: Eliminate Parkinson's disease in our lifetime. Today we are the ... 20 years since he publicly disclosed he has Parkinson's, Michael J. Fox sits down with Jane Pauley ...

  7. Research in Foundation Grouting with Cement

    Science.gov (United States)

    1960-03-01

    were not obtained, it was the opinion of the reporting engineer that higher strength than that indicated could be realized by allowing for the...overlapping of the piling an- using lar-ger dia-meter than she 4.8-in, cores tested. It was the Coliets opinion that a d-ced-in-place pile wall was a... lideration , and to collect data that might aid in the determination of the grPcthbility of sands and in the selection of suitable gi juts. In order to

  8. A Summary of the Foundation Research Program.

    Science.gov (United States)

    1980-03-01

    Modelling," Operations-analytische Spiele fur die Verteidigung, R. K. Huber, K. Niemeyer and H. W. Hofmann (E𔃻itors), Oldenbourg, Munchen, pp 139-189, 1979...preparation. 50 Title: Aerodynamic Stabilization of Gaseous Discharges Investigators: Oscar Biblarz, Associate Professor of Aeronautics, J. Stricker, Adjunct

  9. Institutional Support : Economic and Social Research Foundation ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Tanzania). Au départ la division tanzanienne du Réseau d'études sur la politique technologique en Afrique (African Technology Policy Studies Network), et ce, depuis 1984, ATPS-Tanzania est devenu... Voir davantageSoutien institutionnel à ...

  10. Fisher Center for Alzheimer's Research Foundation

    Science.gov (United States)

    ... CEO of the Fisher Center, describe his new book and the power of art therapy Click Here ... including The New York Times, Nature, and the Proceedings of the National Academy of Sciences. Every article ...

  11. Foundations of Logistics and Supply Chain Research

    DEFF Research Database (Denmark)

    Georgi, Christoph; Darkow, Inga-Lena; Kotzab, Herbert

    2013-01-01

    17,000 references of 412 papers and further analysed the 39 top-references with the means of multidimensional scaling (MDS), cluster- and factor analysis. We were able to identify a mix of textbooks and articles from academic journals and revealed a journal-specific citation pattern, not only...... in the choice of textbooks but also in the choice of referenced methodology papers. We were also able to identify citation streams and citation areas, where it was surprising to find so many general socio-scientific papers and general papers explaining the character of the field....

  12. Foundations of resilience thinking.

    Science.gov (United States)

    Curtin, Charles G; Parker, Jessica P

    2014-08-01

    Through 3 broad and interconnected streams of thought, resilience thinking has influenced the science of ecology and natural resource management by generating new multidisciplinary approaches to environmental problem solving. Resilience science, adaptive management (AM), and ecological policy design (EPD) contributed to an internationally unified paradigm built around the realization that change is inevitable and that science and management must approach the world with this assumption, rather than one of stability. Resilience thinking treats actions as experiments to be learned from, rather than intellectual propositions to be defended or mistakes to be ignored. It asks what is novel and innovative and strives to capture the overall behavior of a system, rather than seeking static, precise outcomes from discrete action steps. Understanding the foundations of resilience thinking is an important building block for developing more holistic and adaptive approaches to conservation. We conducted a comprehensive review of the history of resilience thinking because resilience thinking provides a working context upon which more effective, synergistic, and systems-based conservation action can be taken in light of rapid and unpredictable change. Together, resilience science, AM, and EPD bridge the gaps between systems analysis, ecology, and resource management to provide an interdisciplinary approach to solving wicked problems. © 2014 Society for Conservation Biology.

  13. The logical foundations of mathematics

    CERN Document Server

    Hatcher, William S

    1981-01-01

    The Logical Foundations of Mathematics offers a study of the foundations of mathematics, stressing comparisons between and critical analyses of the major non-constructive foundational systems. The position of constructivism within the spectrum of foundational philosophies is discussed, along with the exact relationship between topos theory and set theory.Comprised of eight chapters, this book begins with an introduction to first-order logic. In particular, two complete systems of axioms and rules for the first-order predicate calculus are given, one for efficiency in proving metatheorems, and

  14. Una mirada a medio siglo de cimentaciones laminares, métodos de cálculo e investigaciones asociadas en Cuba A look at half a century of shells foundations, methods of calculation and associate research in Cuba

    Directory of Open Access Journals (Sweden)

    Ángel Emilio Castañeda

    2011-12-01

    Full Text Available El trabajo presenta un resumen de las cimentaciones laminares más significativas construidas en Cuba en los últimos decenios y los desarrollos asociados a estas en cuanto a métodos de cálculo de láminas y cascarones de geometría compleja mediante superficies y cuerpos de referencia, a partir de la generalización del método de las solicitaciones proyectadas (Pücher, 1934 con el empleo de superficies de referencia (Hernández, 1970 y otros desarrollos alcanzados en la mecánica del sólido deformable mediante el Método de la Dualidad (Rianitsiyn, 1974; Castañeda, 1993 y la Analogía estático-geométrica en la mecánica del sólido deformable (Castañeda, 1985. Incluye además una síntesis de las investigaciones desarrolladas en los últimos años sobre el estado tenso-deformacional del suelo bajo cimentaciones laminares para chimeneas de 74,5 m en Centrales Azucareros (Cobelo, 2004, estudios comparativos realizados a estas con el empleo del MEF (González, 2010 y otros proyectos investigativos en ejecución actualmente (Álvarez, 2010.The work shows a summary of the most significant shells foundations built in Cuba in the last decades and the developments related to these in term of methods of calculation of plates and shells of complex geometry using reference surfaces and reference bodies, from the generalization of the projected solicitations method (Pücher, 1934 with the use of referential surfaces (Hernández, 1970 and other developments made in the mechanics of deformable solid by the Method of Duality (Rianitsiyn, 1974; Castañeda, 1993 and the Static-Geometric Analogy in the mechanics of the deformable solid (Castañeda, 1985.It also includes a summary of the research developed in recent years on the stress-strain states of soil under and inside shell foundations for chimneys of 74.5 m in sugar industries (Cobelo, 2004, comparative studies made of these with the use of the FEM (González, 2010 and other research projects

  15. American Macular Degeneration Foundation

    Science.gov (United States)

    ... Macular Degeneration How The Eye Works as a Camera Anatomy of a Normal Human Eye ADA and ... Low Vision Depression and AMD Service Providers Research & Cases AMD Research Genetics of AMD Complement Factor H (CFH) Study on Lutein and AMD Study on Zeaxanthin and ...

  16. Foundation Degree Learning: An Educational Journey of Personal Development

    Science.gov (United States)

    Herrera, Helena; Brown, David; Portlock, Jane

    2015-01-01

    The foundation degree is an intermediate-level qualification designed to widen participation in higher education while providing work-related skills and knowledge. It has a vocational focus and a pedagogic approach that integrates academic and work-based learning. Research into opportunities and the process of learning within foundation degrees is…

  17. Iterative analysis of concrete gravity dam-nonlinear foundation ...

    African Journals Online (AJOL)

    user

    Keywords: Concrete gravity dam; dam-foundation interaction; iterative algorithm; Duncan-Chang model; viscous dashpots. 1. Introduction. Considerable research has been conducted on the subject of dynamic analysis of structure-foundation system. The various numerical methods developed for the analysis of dynamic ...

  18. Foundation Degree Students and Their Educational Decision-Making

    Science.gov (United States)

    Greenbank, Paul

    2009-01-01

    Purpose: The purpose of this paper is to examine the decision-making process of students who decided to study for a foundation degree. Design/methodology/approach: The research involved interviewing 30 students who were on, or had recently completed, a business-related foundation degree. Findings: This study found that students were not adopting a…

  19. Quantum theory informational foundations and foils

    CERN Document Server

    Spekkens, Robert

    2016-01-01

    This book provides the first unified overview of the burgeoning research area at the interface between Quantum Foundations and Quantum Information.  Topics include: operational alternatives to quantum theory, information-theoretic reconstructions of the quantum formalism, mathematical frameworks for operational theories, and device-independent features of the set of quantum correlations. Powered by the injection of fresh ideas from the field of Quantum Information and Computation, the foundations of Quantum Mechanics are in the midst of a renaissance. The last two decades have seen an explosion of new results and research directions, attracting broad interest in the scientific community. The variety and number of different approaches, however, makes it challenging for a newcomer to obtain a big picture of the field and of its high-level goals. Here, fourteen original contributions from leading experts in the field cover some of the most promising research directions that have emerged in the new wave of quant...

  20. Can Innate, modular "foundations" explain morality? Challenges for Haidt's Moral Foundations Theory.

    Science.gov (United States)

    Suhler, Christopher L; Churchland, Patricia

    2011-09-01

    Jonathan Haidt's Moral Foundations Theory is an influential scientific account of morality incorporating psychological, developmental, and evolutionary perspectives. The theory proposes that morality is built upon five innate "foundations," each of which is believed to have been selected for during human evolution and, subsequently, tuned-up by learning during development. We argue here that although some general elements of Haidt's theory are plausible, many other important aspects of his account are seriously flawed. First, innateness and modularity figure centrally in Haidt's account, but terminological and conceptual problems foster confusion and ambiguities. Second, both the theory's proposed number of moral foundations and its taxonomy of the moral domain appear contrived, ignoring equally good candidate foundations and the possibility of substantial intergroup differences in the foundations' contents. Third, the mechanisms (viz., modules) and categorical distinctions (viz., between foundations) proposed by the theory are not consilient with discoveries in contemporary neuroscience concerning the organization, functioning, and development of the brain. In light of these difficulties, we suggest that Haidt's theory is inadequate as a scientific account of morality. Nevertheless, the theory's weaknesses are instructive, and hence, criticism may be useful to psychologists, neuroscientists, and philosophers attempting to advance theories of morality, as well as to researchers wishing to invoke concepts such as innateness and modularity more generally.

  1. Foundations of health psychology

    National Research Council Canada - National Science Library

    Friedman, Howard S; Silver, Roxane Cohen

    2007-01-01

    ... and Effective Treatment 9 Adjustment to Chronic Disease: Progress and Promise in Research Annette L. Stanton and Tracey A. Revenson 203 10 Aging and Health 234 Karen S. Rook, Susan T. Charles, and...

  2. [The influence of the organizational structure on the internal controls of a foundation for cancer research, prevention and care in the interior of the state of São Paulo, Brazil].

    Science.gov (United States)

    Bonacim, Carlos Alberto Grespam; Salgado, André Luís; Girioli, Lumila Souza; de Araujo, Adriana Maria Procópio

    2011-05-01

    This work focuses on a discussion about the extent to which the level of organizational structure interferes in the internal control practices of non-governmental organizations (NGOs), especially those related to health. The objective of this work was to observe the efficiency of the internal control tests applied within the organizational structure of the Foundation for Cancer Research, Prevention and Care, checking the reliability of the accounting records and operational controls. A case study in a third sector health organization was the chosen methodology. The case study involved company interviews and the analysis of confidential reports. After an evaluation of the organizational structure (of the relations between officials and volunteers) and the application of evaluation proceedings on the quality of the internal controls, the extent to which the organizational structure interferes with the internal control practices of the hospital was assessed. It was revealed that there are structured mechanisms of control in the institution, however the implementation of these controls is inadequately performed. It was further detected that the level of the organizational structure does indeed interfere in internal control practices at the entity.

  3. "The Trampoline Tree and the Swamp Monster with 18 Heads": Outdoor Play in the Foundation Stage and Foundation Phase

    Science.gov (United States)

    Waller, Tim

    2007-01-01

    This paper considers pedagogy and outdoor play in the early years. The particular focus is on the specific features and benefits of outdoor play in the Foundation Stage (England) and Foundation Phase (Wales). The paper will draw on current international literature and evidence from outdoor learning constructed in an ongoing research project in two…

  4. A four-country comparison of healthcare systems, implementation of diagnostic criteria, and treatment availability for functional gastrointestinal disorders: a report of the Rome Foundation Working Team on cross-cultural, multinational research.

    Science.gov (United States)

    Schmulson, M; Corazziari, E; Ghoshal, U C; Myung, S-J; Gerson, C D; Quigley, E M M; Gwee, K-A; Sperber, A D

    2014-10-01

    Variations in healthcare provision around the world may impact how patients with functional gastrointestinal disorder (FGIDs) are investigated, diagnosed, and treated. However, these differences have not been reviewed. The Multinational Working Team of the Rome Foundation, established to make recommendations on the conduct of multinational, cross-cultural research in FGIDs, identified seven key issues that are analyzed herein: (i) coverage afforded by different healthcare systems/providers; (ii) level of the healthcare system where patients with FGIDs are treated; (iii) extent/types of diagnostic procedures typically undertaken to diagnose FGIDs; (iv) physicians' familiarity with and implementation of the Rome diagnostic criteria in clinical practice; (v) range of medications approved for FGIDs and approval process for new agents; (vi) costs involved in treating FGIDs; and (vii) prevalence and role of complementary/alternative medicine (CAM) for FGIDs. Because it was not feasible to survey all countries around the world, we compared a selected number of countries based on their geographical and ethno-cultural diversity. Thus, we included Italy and South Korea as representative of nations with broad-based coverage of healthcare in the population and India and Mexico as newly industrialized countries where there may be limited provision of healthcare for substantial segments of the population. In light of the paucity of formal publications on these issues, we included additional sources from the medical literature as well as perspectives provided by local experts and the media. Finally, we provide future directions on healthcare issues that should be taken into account and implemented when conducting cross-cultural and multinational research in FGIDs. © 2014 John Wiley & Sons Ltd.

  5. Robert Wood Johnson Foundation

    Science.gov (United States)

    ... SUBMIT CANCEL Stay connected Twitter Facebook Email Linkedin Google+ YouTube RSS Our mission: to improve the health and health care of all Americans. How We Work Grants and Grant Programs Research, Evaluation and Learning Building a Culture of Health Our Focus Areas Health Leadership Health ...

  6. Evolutionary foundations for cancer biology.

    Science.gov (United States)

    Aktipis, C Athena; Nesse, Randolph M

    2013-01-01

    New applications of evolutionary biology are transforming our understanding of cancer. The articles in this special issue provide many specific examples, such as microorganisms inducing cancers, the significance of within-tumor heterogeneity, and the possibility that lower dose chemotherapy may sometimes promote longer survival. Underlying these specific advances is a large-scale transformation, as cancer research incorporates evolutionary methods into its toolkit, and asks new evolutionary questions about why we are vulnerable to cancer. Evolution explains why cancer exists at all, how neoplasms grow, why cancer is remarkably rare, and why it occurs despite powerful cancer suppression mechanisms. Cancer exists because of somatic selection; mutations in somatic cells result in some dividing faster than others, in some cases generating neoplasms. Neoplasms grow, or do not, in complex cellular ecosystems. Cancer is relatively rare because of natural selection; our genomes were derived disproportionally from individuals with effective mechanisms for suppressing cancer. Cancer occurs nonetheless for the same six evolutionary reasons that explain why we remain vulnerable to other diseases. These four principles-cancers evolve by somatic selection, neoplasms grow in complex ecosystems, natural selection has shaped powerful cancer defenses, and the limitations of those defenses have evolutionary explanations-provide a foundation for understanding, preventing, and treating cancer.

  7. Polish Foundation for Energy Efficiency

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-12-31

    The Polish Foundation for Energy Efficiency (FEWE) was established in Poland at the end of 1990. FEWE, as an independent and non-profit organization, has the following objectives: to strive towards an energy efficient national economy, and to show the way and methods by use of which energy efficiency can be increased. The activity of the Foundation covers the entire territory of Poland through three regional centers: in Warsaw, Katowice and Cracow. FEWE employs well-known and experienced specialists within thermal and power engineering, civil engineering, economy and applied sciences. The organizer of the Foundation has been Battelle Memorial Institute - Pacific Northwest Laboratories from the USA.

  8. Excavationless Exterior Foundation Insulation Field Study

    Energy Technology Data Exchange (ETDEWEB)

    Schirber, T. [NorthernSTAR, Minneaplolis, MN (United States); Mosiman, G. [NorthernSTAR, Minneaplolis, MN (United States); Ojczyk, C. [NorthernSTAR, Minneaplolis, MN (United States)

    2014-09-01

    Building science research supports installing exterior (soil side) foundation insulation as the optimal method to enhance the hygrothermal performance of new homes. With exterior foundation insulation, water management strategies are maximized while insulating the basement space and ensuring a more even temperature at the foundation wall. However, such an approach can be very costly and disruptive when applied to an existing home, requiring deep excavation around the entire house. The NorthernSTAR Building America Partnership team implemented an innovative, minimally invasive foundation insulation upgrade technique on an existing home. The approach consisted of using hydrovac excavation technology combined with liquid insulating foam. The team was able to excavate a continuous 4 inches wide by 4 feet to 5 feet deep trench around the entire house, 128 linear feet, except for one small part under the stoop that was obstructed with concrete debris. The combination pressure washer and vacuum extraction technology also enabled the elimination of large trenches and soil stockpiles normally produced by backhoe excavation. The resulting trench was filled with liquid insulating foam, which also served as a water-control layer of the assembly. The insulation was brought above grade using a liquid foam/rigid foam hybrid system and terminated at the top of the rim joist. Cost savings over the traditional excavation process ranged from 23% to 50%. The excavationless process could result in even greater savings since replacement of building structures, exterior features, utility meters, and landscaping would be minimal or non-existent in an excavationless process.

  9. Excavationless Exterior Foundation Insulation Field Study

    Energy Technology Data Exchange (ETDEWEB)

    Schirber, T.; Mosiman, G.; Ojczyk, C.

    2014-10-01

    Building science research supports installing exterior (soil side) foundation insulation as the optimal method to enhance the hygrothermal performance of new homes. With exterior foundation insulation, water management strategies are maximized while insulating the basement space and ensuring a more even temperature at the foundation wall. However, such an approach can be very costly and disruptive when applied to an existing home, requiring deep excavation around the entire house. The NorthernSTAR Building America Partnership team implemented an innovative, minimally invasive foundation insulation upgrade technique on an existing home. The approach consisted of using hydrovac excavation technology combined with a liquid insulating foam. The team was able to excavate a continuous 4" wide by 4' to 5' deep trench around the entire house, 128 linear feet, except for one small part under the stoop that was obstructed with concrete debris. The combination pressure washer and vacuum extraction technology also enabled the elimination of large trenches and soil stockpiles normally produced by backhoe excavation. The resulting trench was filled with liquid insulating foam, which also served as a water-control layer of the assembly. The insulation was brought above grade using a liquid foam/rigid foam hybrid system and terminated at the top of the rim joist. Cost savings over the traditional excavation process ranged from 23% to 50%. The excavationless process could result in even greater savings since replacement of building structures, exterior features, utility meters, and landscaping would be minimal or non-existent in an excavationless process.

  10. Foundations for low cost buildings

    Directory of Open Access Journals (Sweden)

    Sayed Abdel Salam

    2017-04-01

    Full Text Available Attaining an economical and safe design of structures is regarded as a prerequisite for the structural engineer. The market prices of reinforcing steels have dramatically soared in recent years internationally. Therefore, the purpose of the current paper is not just reducing the ratio of reinforcing steel in the foundations for skeleton structures, but rather minimizing this ratio through choosing the most effective footing shape (folded strip footings. Folded footings have been used as an alternative to the conventional rectangular strip footings. The height of the studied model is ten floors. Two different foundation systems are used in the analysis namely; rectangular strip footings, and folded strip footings respectively. Both footing shapes will be designed as continuous footings with grid shape under the building. Comparison between the two systems is also presented regarding the concrete sections and reinforcement ratio under the same applied loads. The finite element analysis software ADINA is used in modeling and analysis of the structural and geotechnical behavior of both types of footings, with emphasis on the effect of changing the footing shape on the stresses in the footing concrete body and the underlying soils. Research results presents the internal stresses within the footing and soil domains, as well as the contact pressure distribution for a reinforced folded strip footing resting on different soil types. The influence of folding inclination angle, and soil type on the results are also studied. Results showed that folded strip footings are efficient in reducing the amount of needed reinforcements, and such efficiency in reducing the required steel reinforcement in the footings is depending on the applied footing loads, and to some degree on the soil type and properties. Reduction in the reinforcement ratio between the rectangular and folded footing types is about 26% in favor of the folded strip footings. A comparative

  11. ICASE/LaRC/NSF/ARO Workshop, conducted by the Institute for Computer Applications in Science and Engineering, NASA Langley Research Center, The National Science Foundation and the Army Research Office

    CERN Document Server

    Anderson, W

    2000-01-01

    Over the last decade, the role of computational simulations in all aspects of aerospace design has steadily increased. However, despite the many advances, the time required for computations is far too long. This book examines new ideas and methodologies that may, in the next twenty years, revolutionize scientific computing. The book specifically looks at trends in algorithm research, human computer interface, network-based computing, surface modeling and grid generation and computer hardware and architecture. The book provides a good overview of the current state-of-the-art and provides guidelines for future research directions. The book is intended for computational scientists active in the field and program managers making strategic research decisions.

  12. Foundations of generic optimization

    CERN Document Server

    Iglesias, M; Verschoren, A

    2006-01-01

    The success of a genetic algorithm when applied to an optimization problem depends upon several features present or absent in the problem to be solved, including the quality of the encoding of data, the geometric structure of the search space, deception or epistasis. This book deals essentially with the latter notion, presenting for the first time a complete state-of-the-art research on this notion, in a structured completely self-contained and methodical way. In particular, it contains a refresher on the linear algebra used in the text as well as an elementary introductory chapter on genetic algorithms aimed at readers unacquainted with this notion. In this way, the monograph aims to serve a broad audience consisting of graduate and advanced undergraduate students in mathematics and computer science, as well as researchers working in the domains of optimization, artificial intelligence, theoretical computer science, combinatorics and evolutionary algorithms.

  13. Stochastic relations foundations for Markov transition systems

    CERN Document Server

    Doberkat, Ernst-Erich

    2007-01-01

    Collecting information previously scattered throughout the vast literature, including the author's own research, Stochastic Relations: Foundations for Markov Transition Systems develops the theory of stochastic relations as a basis for Markov transition systems. After an introduction to the basic mathematical tools from topology, measure theory, and categories, the book examines the central topics of congruences and morphisms, applies these to the monoidal structure, and defines bisimilarity and behavioral equivalence within this framework. The author views developments from the general

  14. Philosophical and Ethical Foundations of Systems Thinking

    OpenAIRE

    Debora, Hammond

    2005-01-01

    Drawing on more than a decade of research on the social implications of systems thinking, as well as practical experience in integrative, community-based approaches to education, this paper is an inquiry into philosophical and ethical considerations growing out of recent developments in systems thinking. In his foundational work on general system theory, Ludwig von Bertalanffy distinguishes between three general developments in the systems field: systems technology, systems science, and syste...

  15. 18 February 2013 - Foundation for Polish Science President M. Zylicz signing the guest book with CERN Director for Research and Scientific Computing S. Bertolucci; visiting the ALICE experimental cavern with K. Safarik and L. Graczykowskind LHC tunnel with Technology Department A. Siemko.

    CERN Multimedia

    Samuel Morier-Genoud

    2013-01-01

    18 February 2013 - Foundation for Polish Science President M. Zylicz signing the guest book with CERN Director for Research and Scientific Computing S. Bertolucci; visiting the ALICE experimental cavern with K. Safarik and L. Graczykowskind LHC tunnel with Technology Department A. Siemko.

  16. National Science Foundation Assistant Director for Mathematics and Physical Sciences Tony Chan (USA) visiting CMS experiment on 23rd May 2007 with Spokesperson T. Virdee, Deputy Spokesperson R. Cousins, Advisor to CERN Director-General J. Ellis, US CMS Research Program Deputy Manager D. Marlow and FNAL D. Green

    CERN Multimedia

    Maximilien Brice

    2007-01-01

    National Science Foundation Assistant Director for Mathematics and Physical Sciences Tony Chan (USA) visiting CMS experiment on 23rd May 2007 with Spokesperson T. Virdee, Deputy Spokesperson R. Cousins, Advisor to CERN Director-General J. Ellis, US CMS Research Program Deputy Manager D. Marlow and FNAL D. Green

  17. Evaluation Policy in a Nonprofit Foundation: A Case Study Exploration of the Robert Wood Johnson Foundation

    Science.gov (United States)

    Dillman, Lisa M.; Christie, Christina A.

    2017-01-01

    This study explores the relationship between evaluation policies and evaluation practice. Through document analysis, interviews, and a multiple case study, the research examined the explicit and implicit policies overarching the evaluation work commissioned by the Robert Wood Johnson Foundation (RWJF) and explored how these policies are…

  18. Mathematical foundations of quantum statistics

    CERN Document Server

    Khinchin, A Y

    2011-01-01

    A coherent, well-organized look at the basis of quantum statistics' computational methods, the determination of the mean values of occupation numbers, the foundations of the statistics of photons and material particles, thermodynamics.

  19. Aplastic Anemia & MDS International Foundation

    Science.gov (United States)

    ... Menu Donate In Treatment at NIH "The Aplastic Anemia and MDS International Foundation is helping patients like ... cope with bone marrow failure disease." Diseases Aplastic Anemia Myelodysplastic Syndromes (MDS) Paroxysmal Nocturnal Hemoglobinuria (PNH) Related ...

  20. Crohn's & Colitis Foundation of America

    Science.gov (United States)

    ... to enjoy the full interactive experience. Crohn's & Colitis Foundation of America Find a Doctor Find a support ... Dating & Relationships Diagnosis & Testing Diet & Nutrition Disease Basics Finances Flares Health Insurance Medication Ostomy Patient Rights Pregnancy ...

  1. Kaiser Family Foundation - Content Search

    Data.gov (United States)

    U.S. Department of Health & Human Services — Chartpacks, chartbooks, factsheets, reports, and slide presentations bring Kaiser Family Foundation information to life, and can be easily incorporated into your...

  2. Foundations of radiation hydrodynamics

    CERN Document Server

    Mihalas, Dimitri

    1999-01-01

    Radiation hydrodynamics is a broad subject that cuts across many disciplines in physics and astronomy: fluid dynamics, thermodynamics, statistical mechanics, kinetic theory, and radiative transfer, among others. The theory developed in this book by two specialists in the field can be applied to the study of such diverse astrophysical phenomena as stellar winds, supernova explosions, and the initial phases of cosmic expansion, as well as the physics of laser fusion and reentry vehicles. As such, it provides students with the basic tools for research on radiating flows.Largely self-contained,

  3. Participation in a Year-Long CURE Embedded into Major Core Genetics and Cellular and Molecular Biology Laboratory Courses Results in Gains in Foundational Biological Concepts and Experimental Design Skills by Novice Undergraduate Researchers

    Directory of Open Access Journals (Sweden)

    Marcy A. Peteroy-Kelly

    2017-05-01

    Full Text Available This two-year study describes the assessment of student learning gains arising from participation in a year-long curriculum consisting of a classroom undergraduate research experience (CURE embedded into second-year, major core Genetics and Cellular and Molecular Biology (CMB laboratory courses. For the first course in our CURE, students used micro-array or RNAseq analyses to identify genes important for environmental stress responses by Saccharomyces cerevisiae. The students were tasked with creating overexpressing mutants of their genes and designing their own original experiments to investigate the functions of those genes using the overexpression and null mutants in the second CURE course. In order to evaluate student learning gains, we employed three validated concept inventories in a pretest/posttest format and compared gains on the posttest versus the pretest with student laboratory final grades. Our results demonstrated that there was a significant correlation between students earning lower grades in the Genetics laboratory for both years of this study and gains on the Genetics Concept Assessment (GCA. We also demonstrated a correlation between students earning lower grades in the Genetics laboratory and gains on the Introductory Molecular and Cell Biology Assessment (IMCA for year 1 of the study. Students furthermore demonstrated significant gains in identifying the variable properties of experimental subjects when assessed using the Rubric for Experimental (RED design tool. Results from the administration of the CURE survey support these findings. Our results suggest that a year-long CURE enables lower performing students to experience greater gains in their foundational skills for success in the STEM disciplines.

  4. THE PHILOSOPHICAL FOUNDATIONS OF MODERN BIOENGINEERING

    Directory of Open Access Journals (Sweden)

    Ibrahim A. Shogar

    2017-12-01

    Full Text Available This paper investigates the philosophical foundations of modern bioengineering to articulate its ethical framework. Engineering as an ultimate mechanism to transform knowledge into practice is essential for both physical and biological sciences. It reduces data, concepts, and designs to pictorial forms. The integration of engineering with the newly emerging biosciences, has presented a unique opportunity to overcome the major challenges that face the environmental and human health. To harness potentials of bioengineering and establish a sustainable foundation for green technology, modern scientists and engineers need to be acquainted with the normative questions of science. In addition to acquiring the general principles of scientific research and identifying the intrinsic goals of the endeavour, philosophy of bioengineering exposes bioengineers to both the descriptive ‘how’ questions of the physical world as well as the normative ‘why’ questions of values. Such an interdisciplinary approach is significant, not only for inspiring to acquire the genuine knowledge of the existing world, but also to expose the bioengineers to their ethical and social responsibilities. Besides introducing the conceptual framework of bioengineering, this paper has investigated the three major philosophies that have been dominating the theoretical presuppositions of scientific research method in history. Namely, (i Systems biology approach; (ii Evolutionary biology approach; and (iii Mechanical view approach. To establish the ethical foundation of modern bioengineering, the paper, also has conducted an analytical study on various branches of the emerging discipline of bioscience. The paper has concluded that adopting the interdisciplinary approach in research and education is essential to harness potentials of bioengineering and to establish foundations of green technology. To achieve the final objectives of bioengineering, both the practical and theoretical

  5. Foundations of radiation hydrodynamics

    Science.gov (United States)

    Mihalas, D.; Mihalas, B. W.

    This book is the result of an attempt, over the past few years, to gather the basic tools required to do research on radiating flows in astrophysics. The microphysics of gases is discussed, taking into account the equation of state of a perfect gas, the first and second law of thermodynamics, the thermal properties of a perfect gas, the distribution function and Boltzmann's equation, the collision integral, the Maxwellian velocity distribution, Boltzmann's H-theorem, the time of relaxation, and aspects of classical statistical mechanics. Other subjects explored are related to the dynamics of ideal fluids, the dynamics of viscous and heat-conducting fluids, relativistic fluid flow, waves, shocks, winds, radiation and radiative transfer, the equations of radiation hydrodynamics, and radiating flows. Attention is given to small-amplitude disturbances, nonlinear flows, the interaction of radiation and matter, the solution of the transfer equation, acoustic waves, acoustic-gravity waves, basic concepts of special relativity, and equations of motion and energy.

  6. Progeria 101/FAQ

    Science.gov (United States)

    ... growth failure, loss of body fat and hair, aged-looking skin and stiffness of joints. As children get older, they suffer from osteoporosis, generalized atherosclerosis, cardiovascular (heart) disease and stroke. The ...

  7. On St. Sava’s (svetosavski redaction of Holy Monks images in Mileševa church narthex: Contribution to research in iconographic common places in the Nemanjićs’ church foundation

    Directory of Open Access Journals (Sweden)

    Milanović Vesna D.

    2002-01-01

    Full Text Available This paper discusses the possibility of further completing the to-date analyses on the content and scope of the painting program in the Mileševa narthex, representing a striking two-band frieze of the images of holy monks. This new examination does not ignore the already recognized distinguishing marks, and pays special attention to investigating possible relationships and links with the solutions in some other monuments of the same era not having been previously researched in detail. The undertaking of the author was in this case determined by an attempt to look into and throw some light onto the hardly discernible, and to date unexplained, original content of a smaller, only fragmentarily saved, and indeed the most challenging segment of that numerous and complex gathering of the images of holy monks. That segment included several extremely damaged and rather faded images of holy monks in the lower zone of the narthex southern wall (the band of standing figures, and the figure in the southern end of the adjoining, west wall, in all probability, belonged to it as well. Furthermore, according to the faded traces of previous iconographic characteristics of these figures, it could be seen that they constituted a compact and specific group with regard to the nearest images or groups of images, related to them by belonging to the same, more general category of the holiness. Bearing in mind the damage to heads and faces, as well as the disappearance of the inscription with the names and texts on the scrolls in their hands, the only way to discovering, or at least to closer determining the identity of the images presented was by means of to date unused circumstantial data, which could be provided by more extensive iconographic materials from the other monuments of the time. This way was, up to a certain extent, already open by previous numerous notes of the researchers on the essential closeness of solutions in Mileševa with those of Studenica and

  8. Foundations for the future

    CERN Document Server

    2010-01-01

    Since this is the last Bulletin of 2010, this will be the last word from the Director-General for this remarkable year. I’d like to use it to share some of my reflections on how important it is for CERN, and for science, that the LHC has worked so very well. The scientific results are remarkable, but it’s the political legacy of the LHC’s first year of running that I’d like to talk about here.   Whenever economies are slow, as they are now, basic science comes under pressure as governments look to applied science for winners. Basic science takes too long to deliver products to market – so the conventional logic goes – and it’s much better to concentrate on the applied. There’s merit to this logic, but it’s no cure-all for the economy. We need a broadly balanced approach to science that includes basic and applied research, that harnesses the power of the new media to ensure open access to knowledge, and that...

  9. A behaviorological thanatology: Foundations and implications

    Science.gov (United States)

    Fraley, Lawrence E.

    1998-01-01

    Foundation principles supporting a behaviorological thanatology are reviewed, including concepts of life, person, death, value, right, ethic, and body/person distinctions. These natural science foundations are contrasted with traditional foundations, and their respective implications are speculatively explored. PMID:22478293

  10. Globalising the classical foundations of IPE thought

    Directory of Open Access Journals (Sweden)

    Eric Helleiner

    2015-12-01

    Full Text Available Abstract Current efforts to teach and research the historical foundations of IPE thought in classical political economy in the 18th, 19th and early 20th centuries centre largely on European and American thinkers. If a more extensive 'global conversation' is to be fostered in the field today, the perspectives of thinkers in other regions need to be recognised, and brought into the mainstream of its intellectual history. As a first step towards 'globalising' the classical foundations of IPE thought, this article demonstrates some ways in which thinkers located beyond Europe and the United States engaged with and contributed to debates associated with the three well-known classical traditions on which current IPE scholarship often draws: economic liberalism, economic nationalism and Marxism. It also reveals the extensive nature of 'global conversations' about IPE issues in this earlier era.

  11. Scour around Offshore Wind Turbine Foundations

    DEFF Research Database (Denmark)

    Petersen, Thor Ugelvig

    focuses on the case where the foundation is placed without scour protection. Here the continuously changing flow climate, comprising currents, waves and combined waves and current forces the scour depth around the foundation to change over time experiencing scour and backfill in an alternating fashion...... the changing scour depth over time. It is shown that the scour depth corresponding to the equilibrium stage of the backfilling process is the same as that corresponding to the equilibrium stage of the scour process for the same wave or combined waves and current climate. The time scale of the backfilling....... The scour mechanism and the time development of a scour process in waves, current and steady current has received a vast amount of research over the last decades revealing various features of scour processes. While the scour process seems well documented, relatively few studies have been reported...

  12. Fractal geometry mathematical foundations and applications

    CERN Document Server

    Falconer, Kenneth

    2013-01-01

    The seminal text on fractal geometry for students and researchers: extensively revised and updated with new material, notes and references that reflect recent directions. Interest in fractal geometry continues to grow rapidly, both as a subject that is fascinating in its own right and as a concept that is central to many areas of mathematics, science and scientific research. Since its initial publication in 1990 Fractal Geometry: Mathematical Foundations and Applications has become a seminal text on the mathematics of fractals.  The book introduces and develops the general theory and applica

  13. Moral foundations vignettes: a standardized stimulus database of scenarios based on moral foundations theory.

    Science.gov (United States)

    Clifford, Scott; Iyengar, Vijeth; Cabeza, Roberto; Sinnott-Armstrong, Walter

    2015-12-01

    Research on the emotional, cognitive, and social determinants of moral judgment has surged in recent years. The development of moral foundations theory (MFT) has played an important role, demonstrating the breadth of morality. Moral psychology has responded by investigating how different domains of moral judgment are shaped by a variety of psychological factors. Yet, the discipline lacks a validated set of moral violations that span the moral domain, creating a barrier to investigating influences on judgment and how their neural bases might vary across the moral domain. In this paper, we aim to fill this gap by developing and validating a large set of moral foundations vignettes (MFVs). Each vignette depicts a behavior violating a particular moral foundation and not others. The vignettes are controlled on many dimensions including syntactic structure and complexity making them suitable for neuroimaging research. We demonstrate the validity of our vignettes by examining respondents' classifications of moral violations, conducting exploratory and confirmatory factor analysis, and demonstrating the correspondence between the extracted factors and existing measures of the moral foundations. We expect that the MFVs will be beneficial for a wide variety of behavioral and neuroimaging investigations of moral cognition.

  14. Professional Team Foundation Server 2010

    CERN Document Server

    Blankenship, Ed; Holliday, Grant; Keller, Brian

    2011-01-01

    Authoritative guide to TFS 2010 from a dream team of Microsoft insiders and MVPs!Microsoft Visual Studio Team Foundation Server (TFS) has evolved until it is now an essential tool for Microsoft?s Application Lifestyle Management suite of productivity tools, enabling collaboration within and among software development teams. By 2011, TFS will replace Microsoft?s leading source control system, VisualSourceSafe, resulting in an even greater demand for information about it. Professional Team Foundation Server 2010, written by an accomplished team of Microsoft insiders and Microsoft MVPs, provides

  15. Professional Team Foundation Server 2012

    CERN Document Server

    Blankenship, Ed; Holliday, Grant; Keller, Brian

    2012-01-01

    A comprehensive guide to using Microsoft Team Foundation Server 2012 Team Foundation Server has become the leading Microsoft productivity tool for software management, and this book covers what developers need to know to use it effectively. Fully revised for the new features of TFS 2012, it provides developers and software project managers with step-by-step instructions and even assists those who are studying for the TFS 2012 certification exam. You'll find a broad overview of TFS, thorough coverage of core functions, a look at extensibility options, and more, written by Microsoft ins

  16. ITIL Foundation exam study guide

    CERN Document Server

    Gallacher, Liz

    2012-01-01

    Everything you need to prepare for the ITIL exam The ITIL (Information Technology Infrastructure Library) exam is the ultimate certification for IT service management. This essential resource is a complete guide to preparing for the ITIL Foundation exam and includes everything you need for success. Organized around the ITIL Foundation syllabus, the study guide addresses the ITIL Service Lifecycles, the ITIL processes, roles, and functions, and also thoroughly explains how the Service Lifecycle provides effective and efficient IT services. Offers an introduction to IT service management and ITI

  17. Physical foundations of technical acoustics

    CERN Document Server

    Malecki, I

    1969-01-01

    Physical Foundations of Technical Acoustics discusses theoretical foundations of acoustical engineering. It is not so much a technical compendium as a systematic statement of physical laws so conceived that technologists might find in it all the information they need to become acquainted with the physical meaning and mathematical expression of phenomena they encounter in their work. To facilitate the acquirement of notions, which lie beyond a layman's grasp, the plan of narration adopted consists in beginning with the simplest idealized cases and then gradually moving on to the truest possibl

  18. Investigating the Learning-Theory Foundations of Game-Based Learning: A Meta-Analysis

    Science.gov (United States)

    Wu, W-H.; Hsiao, H-C.; Wu, P-L.; Lin, C-H.; Huang, S-H.

    2012-01-01

    Past studies on the issue of learning-theory foundations in game-based learning stressed the importance of establishing learning-theory foundation and provided an exploratory examination of established learning theories. However, we found research seldom addressed the development of the use or failure to use learning-theory foundations and…

  19. Foundation analyzing of centrifugal ID fans in cement pla

    Directory of Open Access Journals (Sweden)

    Hamid Eskandari

    2016-06-01

    Full Text Available This research was based on a finite-element model (FEM of large foundations such as induced draft (ID fans. Three-dimensional (3D linear analyses were performed under arbitrary static and dynamic loads for various modulus of elasticity of concrete (Ec (20, 25, 28 and 30 GPa and reinforcement (Es (200, 250, 300 GPa. FEM results were compared with the existing ID fan foundations (laboratory-based evidence to assess the accuracy of simulations made by the FEM. This study validated what constitutes a major departure from current thinking regarding material properties modeling of concrete under various loads to increase foundation for lifetime.

  20. Foundations as Promoters of Life Science Start-ups.

    Science.gov (United States)

    Vonmont, Pascale

    2014-12-01

    Because private foundations have only modest financial resources compared to public and private-sector research funding, the only way in which foundations can play a key role is in the initial and risk financing of gap areas. This is generally in what is known as the 'valley of death', but even there an additional focus is needed. One promising field is the very early-stage support for high-risk but high-potential business cases in order to increase the number of start-ups, not only but very often in the field of life sciences. The pre-seed fund venture kick, an initiative by private foundations, is a good example of success. There is still a gap in the innovation chain in Switzerland from the first research results to becoming a successful life science company. However, for the first time promising solutions are on the way, and here too, foundations can play an important role.

  1. Foundation programme: A student's perspective.

    Science.gov (United States)

    Mittal, Rakesh; Mahajan, Rajiv; Mittal, Niti

    2013-01-01

    Various colleges and universities worldwide develop and implement students' orientation programs to acclimatize them to the campus environment, familiarize them with the teaching programs and its importance has been stressed in the document "Vision 2015" planned by the Medical Council of India (MCI). To evaluate the feedback questionnaire after conclusion of two day :Foundation Program" for MBBS 2nd Professional students, conducted by the medical education unit at a tertiary care Medical Institute. After the conclusion of two day "Foundation Program", a pre-designed, anonymous questionnaire was received from all the students who participated in the program. Of the 100 participants, 67% of the participants labeled the foundation program a very good exercise. Students' view regarding the factors that facilitated their learning were good topics (covered important aspects pertaining to the clinical phases), good presentations, good and experienced speakers, and interactive faculty. Such orientation programs lay a strong foundation for better understanding and learning of under-graduate courses, and should be a regular feature in the curriculum.

  2. Conceptual foundations of evolutionary thought

    Indian Academy of Sciences (India)

    2017-07-04

    Jul 4, 2017 ... Home; Journals; Journal of Genetics; Volume 96; Issue 3. Conceptual foundations of evolutionary thought. K. P. MOHANAN. Perspectives Volume 96 Issue 3 July 2017 pp 401-412. Fulltext. Click here to view fulltext PDF. Permanent link: http://www.ias.ac.in/article/fulltext/jgen/096/03/0401-0412. Abstract ...

  3. The Governance of Industrial Foundations

    DEFF Research Database (Denmark)

    Børsting, Christa; Kuhn, Johan; Poulsen, Thomas

    We study turnover among executives and directors in companies owned by Danish industrial foundations, which are held to be long term owners. Executives are members of the management board (direktionen), whereas directors a members of the supervisiory board (bestyrelsen). As expected, we find...

  4. The foundational ontology library ROMULUS

    CSIR Research Space (South Africa)

    Khan, ZC

    2013-09-01

    Full Text Available . We present here a basic step in that direction with the Repository of Ontologies for MULtiple USes, ROMULUS, which is the first online library of machine-processable, modularised, aligned, and logic-based merged foundational ontologies. In addition...

  5. Team Foundation Server 2013 customization

    CERN Document Server

    Beeming, Gordon

    2014-01-01

    This book utilizes a tutorial based approach, focused on the practical customization of key features of the Team Foundation Server for collaborative enterprise software projects.This practical guide is intended for those who want to extend TFS. This book is for intermediate users who have an understanding of TFS, and basic coding skills will be required for the more complex customizations.

  6. Urban heritage, building maintenance : Foundations

    NARCIS (Netherlands)

    Verhoef, L.G.W.

    1999-01-01

    What do we understand by the term 'foundations'? This general idea may embody the literal ' groundwork' that provides support for a building and may possibly include the entire structural works that serve to pre vent subsidence. Remarkably, in this definition the word 'groundwork' incorporates both

  7. Conceptual foundations of evolutionary thought

    Indian Academy of Sciences (India)

    K. P. MOHANAN

    2017-07-04

    Jul 4, 2017 ... This article seeks to explore the conceptual foundations of evolutionary thought in the physical, biological, and human sciences. Viewing evolution as symmetry breaking, it explores the concepts of change, history, and evolutionary history, and outlines a concept of biological macroevolution.

  8. Behavior Modeling -- Foundations and Applications

    DEFF Research Database (Denmark)

    This book constitutes revised selected papers from the six International Workshops on Behavior Modelling - Foundations and Applications, BM-FA, which took place annually between 2009 and 2014. The 9 papers presented in this volume were carefully reviewed and selected from a total of 58 papers...

  9. The foundations of organization power

    NARCIS (Netherlands)

    Clegg, S.R.

    2009-01-01

    I shall argue that the foundations of organization power were laid down in practice through theories of power - in the sense that they sought to explain power - but through quite pragmatic practices that were not necessarily regarded as embodying a theory of power, which I shall maintain they most

  10. The promises of moral foundationalism

    NARCIS (Netherlands)

    Musschenga, A.W.

    2013-01-01

    In this article I examine whether Moral Foundations Theory can fulfil the promises that Haidt claims for the theory: that it will help in developing new approaches to moral education and to the moral conflicts that divide our diverse society. I argue that, first, the model that Haidt suggests for

  11. Foundations and the Advancement of Postsecondary Education

    Science.gov (United States)

    Morris, Libby V.

    2017-01-01

    The author examined the websites of two large foundations, the Bill and Melinda Gates Foundation and the Lumina Foundation. Each has developed projects and networks, coupled with substantive grants, to improve postsecondary education. These and other foundations have deep and ongoing commitments, not just philosophical but resource-based, to…

  12. Study of wind turbine foundations in cold climates

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2012-11-01

    This report provides an overview of the processes at work in soil in cold climates and their effect on wind turbine foundations. Havsnaes wind farm consists of 48 turbines located in Jaemtland county in central Sweden. Havsnaes has provided an appropriate research environment to investigate the engineering challenges related to the design and construction of wind turbine foundations in sub-arctic conditions and the experienced gained from this project informs this report.

  13. Energy biotechnology at the National Science Foundation

    Energy Technology Data Exchange (ETDEWEB)

    Heineken, F.G. [National Science Foundation, Washington, DC (United States)

    1993-12-31

    A number of projects supported by the National Science Foundation (NSF) have possible applications in the area of Energy Biotechnology. These range from studies on the metabolic pathways for solvent and fuel production using microorganisms, both aerobic and anaerobic, to the conversion of biomass for the production of fuels and other chemicals and materials. Other projects focus in on new purification and separation technologies as well as new process monitoring techniques that could have an impact on solvent and fuel production. A brief review of these activities will be presented as well as a discussion of future needs and opportunities for research in Energy Biotechnology at NSF.

  14. Defective DSB repair correlates with abnormal nuclear morphology and is improved with FTI treatment in Hutchinson-Gilford progeria syndrome fibroblasts

    Energy Technology Data Exchange (ETDEWEB)

    Constantinescu, Dan [Department of Cell Biology-Physiology, University of Pittsburgh, Pittsburgh, PA 15260 (United States); Pittsburgh Development Center, Magee-Women' s Research Institute, University of Pittsburgh, Pittsburgh, PA 15260 (United States); Csoka, Antonei B. [Division of Geriatrics, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA 15260 (United States); Navara, Christopher S. [Division of Developmental and Regenerative Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA 15260 (United States); Pittsburgh Development Center, Magee-Women' s Research Institute, University of Pittsburgh, Pittsburgh, PA 15260 (United States); Schatten, Gerald P., E-mail: schattengp@upmc.edu [Division of Developmental and Regenerative Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh, Pittsburgh, PA 15260 (United States); Department of Cell Biology-Physiology, University of Pittsburgh, Pittsburgh, PA 15260 (United States); Pittsburgh Development Center, Magee-Women' s Research Institute, University of Pittsburgh, Pittsburgh, PA 15260 (United States)

    2010-10-15

    Impaired DSB repair has been implicated as a molecular mechanism contributing to the accelerating aging phenotype in Hutchinson-Gilford progeria syndrome (HGPS), but neither the extent nor the cause of the repair deficiency has been fully elucidated. Here we perform a quantitative analysis of the steady-state number of DSBs and the repair kinetics of ionizing radiation (IR)-induced DSBs in HGPS cells. We report an elevated steady-state number of DSBs and impaired repair of IR-induced DSBs, both of which correlated strongly with abnormal nuclear morphology. We recreated the HGPS cellular phenotype in human coronary artery endothelial cells for the first time by lentiviral transduction of GFP-progerin, which also resulted in impaired repair of IR-induced DSBs, and which correlated with abnormal nuclear morphology. Farnesyl transferase inhibitor (FTI) treatment improved the repair of IR-induced DSBs, but only in HGPS cells whose nuclear morphology was also normalized. Interestingly, FTI treatment did not result in a statistically significant reduction in the higher steady-state number of DSBs. We also report a delay in localization of phospho-NBS1 and MRE11, MRN complex repair factors necessary for homologous recombination (HR) repair, to DSBs in HGPS cells. Our results demonstrate a correlation between nuclear structural abnormalities and the DSB repair defect, suggesting a mechanistic link that may involve delayed repair factor localization to DNA damage. Further, our results show that similar to other HGPS phenotypes, FTI treatment has a beneficial effect on DSB repair.

  15. Naïve adult stem cells from patients with Hutchinson-Gilford progeria syndrome express low levels of progerin in vivo

    Directory of Open Access Journals (Sweden)

    Vera Wenzel

    2012-04-01

    Hutchinson-Gilford progeria syndrome (HGPS, OMIM 176670 is a rare disorder characterized by segmental accelerated aging and early death from coronary artery disease or stroke. Nearly 90% of HGPS sufferers carry a G608G mutation within exon 11 of LMNA, producing a truncated form of prelamin A, referred to as “progerin”. Here, we report the isolation of naïve multipotent skin-derived precursor (SKP cells from dermal fibroblast cultures from HGPS donors. These cells form spheres and express the neural crest marker, nestin, in addition to the multipotent markers, OCT4, Sox2, Nanog and TG30; these cells can self-renew and differentiate into smooth muscle cells (SMCs and fibroblasts. The SMCs derived from the HGPS-SKPs accumulate nuclear progerin with increasing passages. A subset of the HGPS-naïve SKPs express progerin in vitro and in situ in HGPS skin sections. This is the first in vivo evidence that progerin is produced in adult stem cells, and implies that this protein could induce stem cells exhaustion as a mechanism contributing to aging. Our study provides a basis on which to explore therapeutic applications for HGPS stem cells and opens avenues for investigating the pathogenesis of other genetic diseases.

  16. The mutant form of lamin A that causes Hutchinson-Gilford progeria is a biomarker of cellular aging in human skin.

    Directory of Open Access Journals (Sweden)

    Dayle McClintock

    2007-12-01

    Full Text Available Hutchinson-Gilford progeria syndrome (HGPS, OMIM 176670 is a rare disorder characterized by accelerated aging and early death, frequently from stroke or coronary artery disease. 90% of HGPS cases carry the LMNA G608G (GGC>GGT mutation within exon 11 of LMNA, activating a splice donor site that results in production of a dominant negative form of lamin A protein, denoted progerin. Screening 150 skin biopsies from unaffected individuals (newborn to 97 years showed that a similar splicing event occurs in vivo at a low level in the skin at all ages. While progerin mRNA remains low, the protein accumulates in the skin with age in a subset of dermal fibroblasts and in a few terminally differentiated keratinocytes. Progerin-positive fibroblasts localize near the basement membrane and in the papillary dermis of young adult skin; however, their numbers increase and their distribution reaches the deep reticular dermis in elderly skin. Our findings demonstrate that progerin expression is a biomarker of normal cellular aging and may potentially be linked to terminal differentiation and senescence in elderly individuals.

  17. Unique Preservation of Neural Cells in Hutchinson- Gilford Progeria Syndrome Is Due to the Expression of the Neural-Specific miR-9 MicroRNA

    Directory of Open Access Journals (Sweden)

    Xavier Nissan

    2012-07-01

    Full Text Available One puzzling observation in patients affected with Hutchinson-Gilford progeria syndrome (HGPS, who overall exhibit systemic and dramatic premature aging, is the absence of any conspicuous cognitive impairment. Recent studies based on induced pluripotent stem cells derived from HGPS patient cells have revealed a lack of expression in neural derivatives of lamin A, a major isoform of LMNA that is initially produced as a precursor called prelamin A. In HGPS, defective maturation of a mutated prelamin A induces the accumulation of toxic progerin in patient cells. Here, we show that a microRNA, miR-9, negatively controls lamin A and progerin expression in neural cells. This may bear major functional correlates, as alleviation of nuclear blebbing is observed in nonneural cells after miR-9 overexpression. Our results support the hypothesis, recently proposed from analyses in mice, that protection of neural cells from progerin accumulation in HGPS is due to the physiologically restricted expression of miR-9 to that cell lineage.

  18. John S. Bell on the foundations of quantum mechanics

    CERN Document Server

    Bell, John S; Gottfried, Kurt; Veltman, Martinus J G

    2001-01-01

    This book is the most complete collection of John S Bell's research papers, review articles and lecture notes on the foundations of quantum mechanics. Some of this material has hitherto been difficult to access. The book also appears in a paperback edition, aimed at students and young researchers. This volume will be very useful to researchers in the foundations and applications of quantum mechanics. Contents: (1) On the Problem of Hidden Variables in Quantum Mechanics; (2) On the Einstein-Podolsky-Rosen Paradox; (3) The Moral Aspect of Quantum Mechanics; (4) Introduction to the Hidden-Variabl

  19. Linear programming foundations and extensions

    CERN Document Server

    Vanderbei, Robert J

    2001-01-01

    Linear Programming: Foundations and Extensions is an introduction to the field of optimization. The book emphasizes constrained optimization, beginning with a substantial treatment of linear programming, and proceeding to convex analysis, network flows, integer programming, quadratic programming, and convex optimization. The book is carefully written. Specific examples and concrete algorithms precede more abstract topics. Topics are clearly developed with a large number of numerical examples worked out in detail. Moreover, Linear Programming: Foundations and Extensions underscores the purpose of optimization: to solve practical problems on a computer. Accordingly, the book is coordinated with free efficient C programs that implement the major algorithms studied: -The two-phase simplex method; -The primal-dual simplex method; -The path-following interior-point method; -The homogeneous self-dual methods. In addition, there are online JAVA applets that illustrate various pivot rules and variants of the simplex m...

  20. Behavior Modeling -- Foundations and Applications

    DEFF Research Database (Denmark)

    This book constitutes revised selected papers from the six International Workshops on Behavior Modelling - Foundations and Applications, BM-FA, which took place annually between 2009 and 2014. The 9 papers presented in this volume were carefully reviewed and selected from a total of 58 papers...... presented at these 6 workshops. The contributions were organized in topical sections named: modelling practices; new ways of behaviour modelling: events in modelling; and new ways of behaviour modelling: protocol modelling....

  1. Mono pile foundation. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Lyngesen, S.; Brendstrup, C.

    1997-02-01

    The use of mono piles as foundations for maritime structures has been developed during the last decades. The installation requirements within the offshore sector have resulted in equipment enabling driving of piles up to 3-4 m to large penetration depths. The availability of this equipment has made the use of large mono piles feasible as foundations for structures like wind turbines. The mono pile foundations consists of three parts; the bare pile, a conical transition and a boat landing. All parts are prefitted at the yard in order to minimise the installation work that has to be carried out offshore. The study of a mono pile foundations for a 1.5 MW wind turbine has been conducted for two locations, Horns Rev and Roedsand. Three different water depths: 5, 8 and 11 m have been investigated in the study. The on-site welding between pile and conical transition is performed by an automatic welding machine. Final testing and eventually repair of the weld are conducted at least 16 hours after welding. This is followed by final installation of J-tube, tie-in to subsea cables and installation of the impressed current system for corrosive protection of the mono pile. The total cost for procurement and installation of the mono pile using the welded connection is estimated. The price does not include procurement and installation of access platform and boat landing. These costs are estimated to 250.000 DKK. Depending on water depth the cost of the pile ranges from 2,2 to 2,7 million DKK. Procurement and fabrication of the pile are approx. 75% of the total costs. The remaining 25% are due to installation. The total costs are very sensitive to the unit price of pile steel. During the project it became obvious that ice load has a very large influence on the dimensions of the mono pile. (EG)

  2. Legal foundations of adaptive licensing.

    Science.gov (United States)

    Oye, K; Baird, L G; Chia, A; Hocking, S; Hutt, P B; Lee, D; Norwalk, L; Salvatore, V

    2013-09-01

    In April 2012, MIT's Center for Biomedical Innovation and the European Medicines Agency (EMA) cosponsored a workshop on legal foundations of adaptive pharmaceuticals licensing. Past and present attorneys from the US Food and Drug Administration (FDA), the EMA, and Health Sciences Agency Singapore (HSA) found that existing statutes provided authority for adaptive licensing (AL). By contrast, an attorney from Health Canada identified gaps in authority. Reimbursement during initial phases of adaptive approaches to licensing was deemed consistent with existing statutes in all jurisdictions.

  3. Mathematical foundation for computer science

    CERN Document Server

    Vashanti, M

    2013-01-01

    "Mathematical Foundation For Computer Science", a textbook covers mathematical logic, Normal Forms, Graphs, Trees and Relations. The emphasis in the book is on the presentation of fundamentals and theoretical concepts in an intelligible and easy to understand manner. Every topic is illustrated with a number of problems of increasing complexities which will help the beginner understand the fundamentals involved and enable them to solve various problems.

  4. Strengthening foundation phase teacher education through mentoring

    Directory of Open Access Journals (Sweden)

    Kerryn Dixon

    2012-07-01

    Full Text Available This paper explores a multidimensional mentorship model implemented between lecturers from the foundation phase at the Wits School of Education and four master’s students from the University of Limpopo, as part of the Departments of Education’s research initiative to strengthen foundation phase teacher education. Using three critical incidents, we interrogate mentors’ experiences of their mentoring practices. Two sets of literature, mentoring and social capital are used as a lens for analysing these incidents. Initial findings suggest the relationship has moved from the initiation to cultivation stage (Kram, 1985; Ragins & Kram, 2007. But, cultural preconceptions, implicit assumptions and institutional practices can impede or enhance information flows and trust. It is argued that weak ties characterised by mentors’ heterogeneity is a strength that has resulted in growing professional development. Through a process of reflection-on-practice, we have begun to think of ourselves as a fledging community of practice. This opens up possibilities for the larger research project.

  5. The Feature of Deformation at Convex Corner of Deep Foundation Pit Based on FLAC3D

    Directory of Open Access Journals (Sweden)

    ZHAO Shun-li

    2016-03-01

    Full Text Available The study on the space-time feature of foundation pit deformation has important significance to ensure the stability of foundation pit engineering. In the present study, the relationship between the space-time fractal feature of foundation pit deformation and the stability of the foundation pit has not been studied adequately. By combining the concrete engineering example, used the FLAC3D software for numerical simulation, and the simulated values were compared with the actual value. Finally, we researched on the relationship between the foundation pit deformation and the stability of foundation pit. Research showed that FLAC3D could reveal the complex spatial and temporal characteristics of foundation pit deformation. But compared with the actual monitoring value, it still has some limitations.

  6. Learning Theory Foundations of Simulation-Based Mastery Learning.

    Science.gov (United States)

    McGaghie, William C; Harris, Ilene B

    2018-01-25

    Simulation-based mastery learning (SBML), like all education interventions, has learning theory foundations. Recognition and comprehension of SBML learning theory foundations are essential for thoughtful education program development, research, and scholarship. We begin with a description of SBML followed by a section on the importance of learning theory foundations to shape and direct SBML education and research. We then discuss three principal learning theory conceptual frameworks that are associated with SBML-behavioral, constructivist, social cognitive-and their contributions to SBML thought and practice. We then discuss how the three learning theory frameworks converge in the course of planning, conducting, and evaluating SBML education programs in the health professions. Convergence of these learning theory frameworks is illustrated by a description of an SBML education and research program in advanced cardiac life support. We conclude with a brief coda.

  7. History on foundation of Korea nuclear energy

    Energy Technology Data Exchange (ETDEWEB)

    Park, Ik Su

    1999-12-15

    This book reports the history of establishment of Korea nuclear power. It is divided into twelve chapters, which deals with situation of domestic and foreign countries before establishment of nuclear power agency, foundation of nuclear power agency and nuclear power research center, the early activity of nuclear power agency and internal conflict, research for nuclear power business and commercialization, new phase and ordeal of administration of nuclear power, the process of nuclear power business, permission and regulation on nuclear power, building of the third and fourth reactor in Yonggwang and antinuclear campaign, establishment of nuclear power plant and commission, introduction of nuclear reprocessing facilities and frustration of nuclear weapon, the process on KEDO, association and social organization related nuclear power.

  8. Feasibility of automated foundational ontology interchangeability

    CSIR Research Space (South Africa)

    Khan, ZC

    2014-11-01

    Full Text Available While a foundational ontology can solve interoperability issues among the domain ontologies aligned to it, multiple foundational ontologies have been developed. Thus, there are still interoperability issues among domain ontologies aligned...

  9. Developing a foundation apprenticeship in care.

    Science.gov (United States)

    Cunningham, A

    This article explores the development of a foundation apprenticeship in care at Sheffield Teaching Hospitals NHS Foundation Trust. The benefits for recruitment and development of the workforce are discussed.

  10. Run-up on Offshore Windturbine Foundations

    DEFF Research Database (Denmark)

    De Vos, Leen; Larsen, Brian Juul; Frigaard, Peter

    For the present report a testprogramme has been performed to determine the run-up on offshore windturbine foundations.......For the present report a testprogramme has been performed to determine the run-up on offshore windturbine foundations....

  11. The Ethical Foundations of Environmental Conservation and ...

    African Journals Online (AJOL)

    REGINALDS

    135-146. Mafeje, Archie. 2002. “Sustainable Development and Poverty Eradication”. Heinrich Boll. Foundation ed. 2002. Sustainable Development, Governance, Globalisation: African. Perspective. Nairobi: Heinrich Boll Foundation, pp.112-125 ...

  12. Foundations of wireless and electronics

    CERN Document Server

    Scroggie, M G

    1984-01-01

    Foundations of Wireless and Electronics, 10th Edition covers the cathode-ray and microwave tubes; modern pulse methods; f.m. detectors; basic processes of transmission; and reception, computers, and non-sinusoidal signal amplification. The book starts by giving a general overview of a complete electronic system, electricity and circuits, capacitance, and inductance. The text also discusses alternating currents (a.c.), including the frequency and phase of a.c.; the capacitance and inductance in a.c. circuits; and the capacitance and inductance in a series. Diodes, triode, transistor equivalent

  13. Foundations of combinatorics with applications

    CERN Document Server

    Bender, Edward A

    2006-01-01

    This introduction to combinatorics, the foundation of the interaction between computer science and mathematics, is suitable for upper-level undergraduates and graduate students in engineering, science, and mathematics.The four-part treatment begins with a section on counting and listing that covers basic counting, functions, decision trees, and sieving methods. The following section addresses fundamental concepts in graph theory and a sampler of graph topics. The third part examines a variety of applications relevant to computer science and mathematics, including induction and recursion, sorti

  14. Letter to European Science Foundation

    Directory of Open Access Journals (Sweden)

    2006-06-01

    Full Text Available Département de Linguistique AppliquéeEt de Didactique des languesDirecteur : Claude Springerhttp://dladl.u-strasbg.fr Dr. Rüdiger KleinEUROCORES Programme CoordinatorEuropean Science Foundation1, quai Lezay MarnésiaBP 90015F-67080 Strasbourg Cedex Strasbourg, le 22 mai 2006 Dear colleague, The Editorial Board of the journal ALSIC (Apprentissage des langues et système d’information et de communication which comprises 45 people from universities in 9 different countries was astonished to note...

  15. Microsoft Windows Identity Foundation Cookbook

    CERN Document Server

    Chanda, Sandeep

    2012-01-01

    This book is written in a simple, easy to understand format, with lots of screenshots and step-by-step explanations.If you are a .NET developer looking forward to building access control in your applications using claims-based identity, then this is the best guide for you. This book is also an excellent choice for professionals and IT administrators trying to enable Single Sign-On across applications within the enterprise, and in the cloud spanning interoperable platforms. No previous knowledge on the subject is necessary, however a strong foundation in the C# programming language and .NET Fra

  16. The shifting foundations of nursing.

    Science.gov (United States)

    Law, Kate; Aranda, Kay

    2010-08-01

    In this paper we argue that the concerns generated by the development of Foundation Degrees and the Assistant and Associate Practitioner roles have rekindled some of the unresolved debates regarding the status and identity of nursing and nurses. Through the application of the sociological theories of professionalisation and nostalgia we have identified the shifting and unresolved nature of nursing. We argue that these theories continue to have resonance in the current climate of change and 'upskilling' of the health care workforce and argue, that the shifts illuminated are perhaps so significant as to demonstrate that we have entered a post-nursing era. Copyright 2009 Elsevier Ltd. All rights reserved.

  17. EVOLUTIONARY FOUNDATIONS FOR MOLECULAR MEDICINE

    Science.gov (United States)

    Nesse, Randolph M.; Ganten, Detlev; Gregory, T. Ryan; Omenn, Gilbert S.

    2015-01-01

    Evolution has long provided a foundation for population genetics, but many major advances in evolutionary biology from the 20th century are only now being applied in molecular medicine. They include the distinction between proximate and evolutionary explanations, kin selection, evolutionary models for cooperation, and new strategies for tracing phylogenies and identifying signals of selection. Recent advances in genomics are further transforming evolutionary biology and creating yet more opportunities for progress at the interface of evolution with genetics, medicine, and public health. This article reviews 15 evolutionary principles and their applications in molecular medicine in hopes that readers will use them and others to speed the development of evolutionary molecular medicine. PMID:22544168

  18. Electromagnetic foundations of electrical engineering

    CERN Document Server

    Faria, J A Brandao

    2008-01-01

    The applications of electromagnetic phenomena within electrical engineering have been evolving and progressing at a fast pace. In contrast, the underlying principles have been stable for a long time and are not expected to undergo any changes. It is these electromagnetic field fundamentals that are the subject of discussion in this book with an emphasis on basic principles, concepts and governing laws that apply across the electrical engineering discipline. Electromagnetic Foundations of Electrical Engineering begins with an explanation of Maxwell's equations, from which the fundament

  19. Deontological foundations for medical ethics?

    Science.gov (United States)

    Gillon, R

    1985-05-04

    Gillon outlines the principles of the deontological, or duty-based, group of moral theories in one of a series of British Medical Journal articles on the philosophical foundations of medical ethics. He differentiates between monistic theories, such as Immanuel Kant's, which rely on a single moral principle, and pluralistic theories, such as that of W.D. Ross, which rely on several principles that potentially could conflict. He summarizes the contributions of Kant and Ross to the development of deontological thought, then concludes his essay with brief paragraphs on other deontological approaches to the resolution of conflicting moral principles.

  20. Quantum mechanics foundations and applications

    CERN Document Server

    Swanson, Donald Gary

    2006-01-01

    Progressing from the fundamentals of quantum mechanics (QM) to more complicated topics, Quantum Mechanics: Foundations and Applications provides advanced undergraduate and graduate students with a comprehensive examination of many applications that pertain to modern physics and engineering.Based on courses taught by the author, this textbook begins with an introductory chapter that reviews historical landmarks, discusses classical theory, and establishes a set of postulates. The next chapter demonstrates how to find the appropriate wave functions for a variety of physical systems in one dimens

  1. Cost-Effective Mass Production of Mono Bucket Foundations

    DEFF Research Database (Denmark)

    Gres, Szymon; Nielsen, Søren Andreas; Fejerskov, Morten

    2015-01-01

    No recognized procedures exist for the Mono Bucket Foundation design, which is an obstruction for mass customization/production and industrialization in relation to certifying authorities. This paper presents the outcome of on-going research and development program that provides solution for inno......No recognized procedures exist for the Mono Bucket Foundation design, which is an obstruction for mass customization/production and industrialization in relation to certifying authorities. This paper presents the outcome of on-going research and development program that provides solution...

  2. Centrifuge model testing for pile foundation reuse

    OpenAIRE

    Begaj, L.; McNamara, A M

    2011-01-01

    With continuous development in the urban environment the ground is becoming more and more congested with redundant foundations. The underground development of services and infrastructure already restricts the location of new building foundations and the redundant foundations only add to this problem. This paper describes how existing single pile foundations in overconsolidated clay are likely to behave when their loading conditions are changed by un-loading caused by demolition and subsequent...

  3. Philanthropy and Private Foundations: Expanding Revenue Sources

    Science.gov (United States)

    Drummer, Carlee; Marshburn, Roxann

    2014-01-01

    As community colleges seek new revenue streams, philanthropic organizations, including college foundations and private funders, have already begun to influence both revenues and college programming. This chapter discusses the current role of philanthropy, especially private foundations such as the Lumina Foundation for Education and the Bill and…

  4. Compressor Foundation Analysis Tool(COFANTO)

    NARCIS (Netherlands)

    Eijk, A.; Lentzen, S.S.K; Zuada Coelho, B.E.; Galanti, F.M.B.

    2012-01-01

    Reciprocating compressors are generally supported on a heavy concrete foundation. In spite of the large inertia and stiffness of the foundation, problems can occur due to interaction between the mechanical installation and the foundation. Two types of problems may occur. In the first type, the

  5. Loss of H3K9me3 Correlates with ATM Activation and Histone H2AX Phosphorylation Deficiencies in Hutchinson-Gilford Progeria Syndrome.

    Directory of Open Access Journals (Sweden)

    Haoyue Zhang

    Full Text Available Compelling evidence suggests that defective DNA damage response (DDR plays a key role in the premature aging phenotypes in Hutchinson-Gilford progeria syndrome (HGPS. Studies document widespread alterations in histone modifications in HGPS cells, especially, the global loss of histone H3 trimethylated on lysine 9 (H3K9me3. In this study, we explore the potential connection(s between H3K9me3 loss and the impaired DDR in HGPS. When cells are exposed to a DNA-damaging agent Doxorubicin (Dox, double strand breaks (DSBs are generated that result in the phosphorylation of histone H2A variant H2AX (gammaH2AX within an hour. We find that the intensities of gammaH2AX foci appear significantly weaker in the G0/G1 phase HGPS cells compared to control cells. This reduction is associated with a delay in the recruitment of essential DDR factors. We further demonstrate that ataxia-telangiectasia mutated (ATM is responsible for the amplification of gammaH2AX signals at DSBs during G0/G1 phase, and its activation is inhibited in the HGPS cells that display significant loss of H3K9me3. Moreover, methylene (MB blue treatment, which is known to save heterochromatin loss in HGPS, restores H3K9me3, stimulates ATM activity, increases gammaH2AX signals and rescues deficient DDR. In summary, this study demonstrates an early DDR defect of attenuated gammaH2AX signals in G0/G1 phase HGPS cells and provides a plausible connection between H3K9me3 loss and DDR deficiency.

  6. Discordant gene expression signatures and related phenotypic differences in lamin A- and A/C-related Hutchinson-Gilford progeria syndrome (HGPS.

    Directory of Open Access Journals (Sweden)

    Martina Plasilova

    Full Text Available Hutchinson-Gilford progeria syndrome (HGPS is a genetic disorder displaying features reminiscent of premature senescence caused by germline mutations in the LMNA gene encoding lamin A and C, essential components of the nuclear lamina. By studying a family with homozygous LMNA mutation (K542N, we showed that HGPS can also be caused by mutations affecting both isoforms, lamin A and C. Here, we aimed to elucidate the molecular mechanisms underlying the pathogenesis in both, lamin A- (sporadic and lamin A and C-related (hereditary HGPS. For this, we performed detailed molecular studies on primary fibroblasts of hetero- and homozygous LMNA K542N mutation carriers, accompanied with clinical examinations related to the molecular findings. By assessing global gene expression we found substantial overlap in altered transcription profiles (13.7%; 90/657 in sporadic and hereditary HGPS, with 83.3% (75/90 concordant and 16.7% (15/90 discordant transcriptional changes. Among the concordant ones we observed down-regulation of TWIST2, whose inactivation in mice and humans leads to loss of subcutaneous fat and dermal appendages, and loss of expression in dermal fibroblasts and periadnexial cells from a LMNA(K542N/K542N patient further confirming its pivotal role in skin development. Among the discordant transcriptional profiles we identified two key mediators of vascular calcification and bone metabolism, ENPP1 and OPG, which offer a molecular explanation for the major phenotypic differences in vascular and bone disease in sporadic and hereditary HGPS. Finally, this study correlates reduced TWIST2 and OPG expression with increased osteocalcin levels, thereby linking altered bone remodeling to energy homeostasis in hereditary HGPS.

  7. Dermal fibroblasts in Hutchinson-Gilford progeria syndrome with the lamin A G608G mutation have dysmorphic nuclei and are hypersensitive to heat stress

    Directory of Open Access Journals (Sweden)

    Worman Howard J

    2005-06-01

    Full Text Available Abstract Background Hutchinson-Gilford progeria syndrome (HGPS, OMIM 176670 is a rare sporadic disorder with an incidence of approximately 1 per 8 million live births. The phenotypic appearance consists of short stature, sculptured nose, alopecia, prominent scalp veins, small face, loss of subcutaneous fat, faint mid-facial cyanosis, and dystrophic nails. HGPS is caused by mutations in LMNA, the gene that encodes nuclear lamins A and C. The most common mutation in subjects with HGPS is a de novo single-base pair substitution, G608G (GGC>GGT, within exon 11 of LMNA. This creates an abnormal splice donor site, leading to expression of a truncated protein. Results We studied a new case of a 5 year-old girl with HGPS and found a heterozygous point mutation, G608G, in LMNA. Complementary DNA sequencing of RNA showed that this mutation resulted in the deletion of 50 amino acids in the carboxyl-terminal tail domain of prelamin A. We characterized a primary dermal fibroblast cell line derived from the subject's skin. These cells expressed the mutant protein and exhibited a normal growth rate at early passage in primary culture but showed alterations in nuclear morphology. Expression levels and overall distributions of nuclear lamins and emerin, an integral protein of the inner nuclear membrane, were not dramatically altered. Ultrastructural analysis of the nuclear envelope using electron microscopy showed that chromatin is in close association to the nuclear lamina, even in areas with abnormal nuclear envelope morphology. The fibroblasts were hypersensitive to heat shock, and demonstrated a delayed response to heat stress. Conclusion Dermal fibroblasts from a subject with HGPS expressing a mutant truncated lamin A have dysmorphic nuclei, hypersensitivity to heat shock, and delayed response to heat stress. This suggests that the mutant protein, even when expressed at low levels, causes defective cell stability, which may be responsible for phenotypic

  8. Cold war, quantum foundations, and East-West collaboration

    Energy Technology Data Exchange (ETDEWEB)

    Skaar-Jacobsen, Anja [Niels Bohr Archive, Copenhagen (Germany)

    2011-07-01

    It is well-known that the cultural cold war changed the ideological line in the Soviet Union from the late 1940s and that this had serious implications for the autonomy of research in genetics and quantum foundations in the East bloc. However, besides the more narrow concern from the point of view of research in quantum foundations, I suggest that the ideological impact on quantum foundations also constituted an obstacle for attempts by Western physicists to bring about a rapprochement between physics in the east and west in general. In connection with re-establishing East-West co-operation between physicists after Stalin's death in 1953 this obstacle needed to be cleared away. In my talk I discuss these issues and how the Institute for Theoretical Physics in Copenhagen came to be an important meeting place for physicists from the East and West from the mid-1950s.

  9. Stiffness Formulation of Flexible Bucket Foundation

    DEFF Research Database (Denmark)

    Ibsen, Lars Bo; Liingaard, Morten; Larsen, Kim André

    that it can be properly included and analysed in a composite structure-foundation system. The typical approach for analysing the structure-foundation system is to use a finite-element method. Such an approach is, however, inefficient and time consuming. The Elastic Macro Model describes the foundation......The response of offshore wind turbines e.g. static, eigen frequencies and eigen modes, are affected by elastic properties of the foundation and the subsoil. The Elastic Macro Model is developed to evaluate the soil-structure interaction of flexible bucket foundations for offshore wind turbines so...

  10. Instability of Bucket Foundations during Installation

    DEFF Research Database (Denmark)

    Madsen, Søren; Andersen, Lars Vabbersgaard; Ibsen, Lars Bo

    The bucket foundation is an upcoming technology for offshore wind turbines. The bucket foundation is a large cylindrical monopod foundation constructed as a thin steel shell structure. A bucket foundation does not require heavy installation equipment since it is installed by suction forces....... The combination of a thin shell structure and suction forces leads to the fact that instability, in form of buckling, becomes a crucial issue during installation. The hydrostatic buckling pressure of the bucket foundation is addressed using three-dimensional, non-linear finite element analysis. The results...

  11. Activating analytic thinking enhances the value given to individualizing moral foundations.

    Science.gov (United States)

    Yilmaz, Onurcan; Saribay, S Adil

    2017-08-01

    Two central debates within Moral Foundations Theory concern (1) which moral foundations are core and (2) how conflict between ideological camps stemming from valuing different moral foundations can be resolved. Previous studies have attempted to answer the first question by imposing cognitive load on participants to direct them toward intuitive and automatic thought. However, this method has limitations and has produced mixed findings. In the present research, in two experiments, instead of directing participants toward intuitive thought, we tested the effects of activating high-effort, analytic thought on participants' moral foundations. In both experiments, analytic thought activation caused participants to value individualizing foundations greater than the control condition. This effect was not qualified by participants' political orientation. No effect was observed on binding foundations. The results are consistent with the idea that upholding individualizing foundations requires mental effort and may provide the basis for reconciliation between different ideological camps. Copyright © 2017 Elsevier B.V. All rights reserved.

  12. Research

    African Journals Online (AJOL)

    raoul

    2011-12-15

    Dec 15, 2011 ... Collaborations. The Program has developed collaborative relationships with several multilateral agencies including the World Bank, European Union, the Division for International Development (DFID) and UN agencies like WHO, UNHCR, WFP and Gates Foundation, and National Institute of Health (NIH) ...

  13. Foundations of pulsed power technology

    CERN Document Server

    Lehr, Janet

    2018-01-01

    Pulsed power technologies could be an answer to many cutting-edge applications. The challenge is in how to develop this high-power/high-energy technology to fit current market demands of low-energy consuming applications. This book provides a comprehensive look at pulsed power technology and shows how it can be improved upon for the world of today and tomorrow. Foundations of Pulsed Power Technology focuses on the design and construction of the building blocks as well as their optimum assembly for synergetic high performance of the overall pulsed power system. Filled with numerous design examples throughout, the book offers chapter coverage on various subjects such as: Marx generators and Marx-like circuits; pulse transformers; pulse-forming lines; closing switches; opening switches; multi-gigawatt to multi-terawatt systems; energy storage in capacitor banks; electrical breakdown in gases; electrical breakdown in solids, liquids and vacuum; pulsed voltage and current measurements; electromagnetic interferen...

  14. Offshore Wind Turbine Foundation Design

    DEFF Research Database (Denmark)

    Passon, Patrik

    continued into 2015 it is even more important to drive down the costs of energy for renewable energy sources such as offshore wind energy in order to arrive at a sustainable future on a global level.Cost of energy reductions for offshore wind turbines (OWTs) can be achieved by optimizations on different......-wave correlations are typically subjected to sequential load calculation approaches in an iterative and collaborative process between foundation designer and wind turbine manufacturer. Involvement of these different design parties may be motivated by various aspects such as introduction of state-of-the-art design......Offshore wind energy has greatly matured during the last decade with an annually installed energy capacity exceeding 1 GW. A key factor for further large-scale development of offshore wind energy is a cost of energy reduction. Given for example the drop in oil price since summer 2014, which has...

  15. Interactive data visualization foundations, techniques, and applications

    CERN Document Server

    Ward, Matthew; Keim, Daniel

    2010-01-01

    Visualization is the process of representing data, information, and knowledge in a visual form to support the tasks of exploration, confirmation, presentation, and understanding. This book is designed as a textbook for students, researchers, analysts, professionals, and designers of visualization techniques, tools, and systems. It covers the full spectrum of the field, including mathematical and analytical aspects, ranging from its foundations to human visual perception; from coded algorithms for different types of data, information and tasks to the design and evaluation of new visualization techniques. Sample programs are provided as starting points for building one's own visualization tools. Numerous data sets have been made available that highlight different application areas and allow readers to evaluate the strengths and weaknesses of different visualization methods. Exercises, programming projects, and related readings are given for each chapter. The book concludes with an examination of several existin...

  16. Towards a paradigmatic foundation of accounting practice

    DEFF Research Database (Denmark)

    Nørreklit, Hanne; Nørreklit, Lennart; Mitchell, Falconer

    2010-01-01

    Purpose - The purpose of this paper is to propose a framework (pragmatic constructivism) for a new paradigm for accounting practice. The paradigmatic base of practice is an important element in explaining, understanding, justifying and defending practice. Design/methodology/approach - The paper...... is designed to argue the case for the use of pragmatic constructivism as a basis for the development of a paradigmatic foundation of accounting practice. To achieve this, pragmatic constructivism is explained and its application to accounting is illustrated and contrasted with the traditional paradigm...... of realism. Findings - The analysis shows how the use of a less reductionist paradigm than realism can assist accountants both in the creation of a rationale and a defence for practice. Research limitations/implications - The analysis is exploratory in the sense that a new paradigmatic framework is outlined...

  17. Plasma Physics at the National Science Foundation

    Science.gov (United States)

    Lukin, Vyacheslav

    2017-10-01

    The Town Meeting on Plasma Physics at the National Science Foundation will provide an opportunity for Q&A about the variety of NSF programs and solicitations relevant to a broad cross-section of the academic plasma science community, from graduating college seniors to senior leaders in the field, and from plasma astrophysics to basic physics to plasma engineering communities. We will discuss recent NSF-hosted events, research awards, and multi-agency partnerships aimed at enabling the progress of science in plasma science and engineering. Future outlook for plasma physics and broader plasma science support at NSF, with an emphasis on how you can help NSF to help the community, will be speculated upon within the uncertainty of the federal budgeting process.

  18. Extended equal areas criterion: foundations and applications

    Energy Technology Data Exchange (ETDEWEB)

    Yusheng, Xue [Nanjim Automation Research Institute, Nanjim (China)

    1994-12-31

    The extended equal area criterion (EEAC) provides analytical expressions for ultra fast transient stability assessment, flexible sensitivity analysis, and means to preventive and emergency controls. Its outstanding performances have been demonstrated by thousands upon thousands simulations on more than 50 real power systems and by on-line operation records in an EMS environment of Northeast China Power System since September 1992. However, the researchers have mainly based on heuristics and simulations. This paper lays a theoretical foundation of EEAC and brings to light the mechanism of transient stability. It proves true that the dynamic EEAC furnishes a necessary and sufficient condition for stability of multi machine systems with any detailed models, in the sense of the integration accuracy. This establishes a new platform for further advancing EEAC and better understanding of problems. An overview of EEAC applications in China is also given in this paper. (author) 30 refs.

  19. Foundationalism in Moral Rules and the Problem of Relativism ...

    African Journals Online (AJOL)

    In this paper we undertake a deep critical analysis of the foundations of moral principles. In it we have established that moral rules guiding human conduct are ... Hence, relativism remains a challenge in the attempt to universalize principles of morality. LWATI: A Journal of Contemporary Research, 8(2), 267-273, 2011 ...

  20. Foundations of Pragmatics: the Primacy of Language in African ...

    African Journals Online (AJOL)

    Foundations of Pragmatics: the Primacy of Language in African Music Theory, Practice and Education. ... It is hoped that this paper would draw our attention more to the beauty and good characteristics of our own music, and arouse our research instincts towards its intellectual repackaging, for global appreciation and ...

  1. Cost-Effective Mass Production of Mono Bucket Foundations

    DEFF Research Database (Denmark)

    Gres, Szymon; Nielsen, Søren Andreas; Fejerskov, Morten

    2015-01-01

    No recognized procedures exist for the Mono Bucket Foundation design, which is an obstruction for mass customization/production and industrialization in relation to certifying authorities. This paper presents the outcome of on-going research and development program that provides solution...

  2. Main issues of pile foundation at waterfront development and its prevention method

    Science.gov (United States)

    Manap, N.; Tan, K. Y.; Syahrom, N.

    2017-12-01

    Pile foundation is widely used in construction and building marine structures. This is because pile foundation is an important structure and should have long-term durability. However, in waterfront development, a lot of issues from the seawater should be considered distinctively because it consists of many problems that can affect the building structure especially the foundation of the building. Thus, a research should be conducted to identify issues of pile foundation at waterfront development and determine its prevention methods. The research was carried out through interviews with the developers and contractors from the projects of Lexis Hibiscus at Port Dickson, Negeri Sembilan and Redevelopment for Deep-Water Facilities at Quay 6 in Pasir Gudang, Johor, Malaysia. The objectives of this research are to identify issues of pile foundation and to determine the prevention methods of pile foundation issues at waterfront development. All respondents agreed that the main issues of pile foundations at waterfront development are the wave and tide condition. The prevention methods of the issue faced at waterfront development that are most frequently used for the pile foundation are coating system and concrete cover. This research is beneficial to all developers and contractors to ensure pile foundations at waterfront development can be protected by using the prevention methods.

  3. Design of a New Foundation for Offshore Wind Turbines

    DEFF Research Database (Denmark)

    Ibsen, Lars Bo; Brincker, Rune

    2004-01-01

    as compared to a traditional pile foundation, it is much easier to install and it can easily be removed when the wind turbine is taken down. However, the new design is suffering from uncertainties in the accumulated fatigue in the both the steel structure and the surrounding earth material. Therefore an on......The gravitation platform and the monopile have in the previous major offshore wind turbine projects been dominating. A four-year research and development project has proven the bucket foundation to be feasible in suitable soil condition in water depth from near shore to app. 40 meters. A prototype...

  4. Foundation analyzing of centrifugal ID fans in cement plants

    OpenAIRE

    Eskandari, Hamid; Nik, Morteza; Pakzad, Amir

    2017-01-01

    This research was based on a finite-element model (FEM) of large foundations such as induced draft (ID) fans. Three-dimensional (3D) linear analyses were performed under arbitrary static and dynamic loads for various modulus of elasticity of concrete (Ec) (20, 25, 28 and 30 GPa) and reinforcement (Es) (200, 250, 300 GPa). FEM results were compared with the existing ID fan foundations (laboratory-based evidence) to assess the accuracy of simulations made by the FEM. This study validated what c...

  5. SPECIFICATION OF ENGINEERING PROPOSALS FOR FOUNDATIONS ON COMPACTED FILLS

    Directory of Open Access Journals (Sweden)

    V.A. Kovalev

    2017-06-01

    Full Text Available In the present article engineering proposals (operation schedules for foundations on compacted fills, aimed to improve their bearing capability, labour intensity (energy requirement decrement, primarily in a rugged geological profile including thixotropic, heaving (swelling, collapsible, filled and other similar types of soils, have been outlined. The main technological processes applied to foundation works in tamped ditches, with the use of drop-in blocks, cast-in-situ and displacement stilts in drilled wells, including short stilts with rigging on a crane-type excavator of improved design have been researched.

  6. The road to Maxwell's demon conceptual foundations of statistical mechanics

    CERN Document Server

    Hemmo, Meir

    2012-01-01

    Time asymmetric phenomena are successfully predicted by statistical mechanics. Yet the foundations of this theory are surprisingly shaky. Its explanation for the ease of mixing milk with coffee is incomplete, and even implies that un-mixing them should be just as easy. In this book the authors develop a new conceptual foundation for statistical mechanics that addresses this difficulty. Explaining the notions of macrostates, probability, measurement, memory, and the arrow of time in statistical mechanics, they reach the startling conclusion that Maxwell's Demon, the famous perpetuum mobile, is consistent with the fundamental physical laws. Mathematical treatments are avoided where possible, and instead the authors use novel diagrams to illustrate the text. This is a fascinating book for graduate students and researchers interested in the foundations and philosophy of physics.

  7. Towards an arithmetical logic the arithmetical foundations of logic

    CERN Document Server

    Gauthier, Yvon

    2015-01-01

    This book offers an original contribution to the foundations of logic and mathematics, and focuses on the internal logic of mathematical theories, from arithmetic or number theory to algebraic geometry. Arithmetical logic is the term used to refer to the internal logic of classical arithmetic, here called Fermat-Kronecker arithmetic, and combines Fermat’s method of infinite descent with Kronecker’s general arithmetic of homogeneous polynomials. The book also includes a treatment of theories in physics and mathematical physics to underscore the role of arithmetic from a constructivist viewpoint. The scope of the work intertwines historical, mathematical, logical and philosophical dimensions in a unified critical perspective; as such, it will appeal to a broad readership from mathematicians to logicians, to philosophers interested in foundational questions. Researchers and graduate students in the fields of philosophy and mathematics will benefit from the author’s critical approach to the foundations of l...

  8. Research protocol: EB-GIS4HEALTH UK – foundation evidence base and ontology-based framework of modular, reusable models for UK/NHS health and healthcare GIS applications

    Directory of Open Access Journals (Sweden)

    Boulos Maged

    2005-01-01

    Full Text Available Abstract EB-GIS4HEALTH UK aims at building a UK-oriented foundation evidence base and modular conceptual models for GIS applications and programmes in health and healthcare to improve the currently poor GIS state of affairs within the NHS; help the NHS understand and harness the importance of spatial information in the health sector in order to better respond to national health plans, priorities, and requirements; and also foster the much-needed NHS-academia GIS collaboration. The project will focus on diabetes and dental care, which together account for about 11% of the annual NHS budget, and are thus important topics where GIS can help optimising resource utilisation and outcomes. Virtual e-focus groups will ensure all UK/NHS health GIS stakeholders are represented. The models will be built using Protégé ontology editor http://protege.stanford.edu/ based on the best evidence pooled in the project's evidence base (from critical literature reviews and e-focus groups. We will disseminate our evidence base, GIS models, and documentation through the project's Web server. The models will be human-readable in different ways to inform NHS GIS implementers, and it will be possible to also use them to generate the necessary template databases (and even to develop "intelligent" health GIS solutions using software agents for running the modelled applications. Our products and experience in this project will be transferable to address other national health topics based on the same principles. Our ultimate goal is to provide the NHS with practical, vendor-neutral, modular workflow models, and ready-to-use, evidence-based frameworks for developing successful GIS business plans and implementing GIS to address various health issues. NHS organisations adopting such frameworks will achieve a common understanding of spatial data and processes, which will enable them to efficiently and effectively share, compare, and integrate their data silos and results for

  9. Forensic bitemark identification: weak foundations, exaggerated claims

    Science.gov (United States)

    Saks, Michael J.; Albright, Thomas; Bohan, Thomas L.; Bierer, Barbara E.; Bowers, C. Michael; Bush, Mary A.; Bush, Peter J.; Casadevall, Arturo; Cole, Simon A.; Denton, M. Bonner; Diamond, Shari Seidman; Dioso-Villa, Rachel; Epstein, Jules; Faigman, David; Faigman, Lisa; Fienberg, Stephen E.; Garrett, Brandon L.; Giannelli, Paul C.; Greely, Henry T.; Imwinkelried, Edward; Jamieson, Allan; Kafadar, Karen; Kassirer, Jerome P.; Koehler, Jonathan ‘Jay’; Korn, David; Mnookin, Jennifer; Morrison, Alan B.; Murphy, Erin; Peerwani, Nizam; Peterson, Joseph L.; Risinger, D. Michael; Sensabaugh, George F.; Spiegelman, Clifford; Stern, Hal; Thompson, William C.; Wayman, James L.; Zabell, Sandy; Zumwalt, Ross E.

    2016-01-01

    Abstract Several forensic sciences, especially of the pattern-matching kind, are increasingly seen to lack the scientific foundation needed to justify continuing admission as trial evidence. Indeed, several have been abolished in the recent past. A likely next candidate for elimination is bitemark identification. A number of DNA exonerations have occurred in recent years for individuals convicted based on erroneous bitemark identifications. Intense scientific and legal scrutiny has resulted. An important National Academies review found little scientific support for the field. The Texas Forensic Science Commission recently recommended a moratorium on the admission of bitemark expert testimony. The California Supreme Court has a case before it that could start a national dismantling of forensic odontology. This article describes the (legal) basis for the rise of bitemark identification and the (scientific) basis for its impending fall. The article explains the general logic of forensic identification, the claims of bitemark identification, and reviews relevant empirical research on bitemark identification—highlighting both the lack of research and the lack of support provided by what research does exist. The rise and possible fall of bitemark identification evidence has broader implications—highlighting the weak scientific culture of forensic science and the law's difficulty in evaluating and responding to unreliable and unscientific evidence. PMID:28852538

  10. Forensic bitemark identification: weak foundations, exaggerated claims.

    Science.gov (United States)

    Saks, Michael J; Albright, Thomas; Bohan, Thomas L; Bierer, Barbara E; Bowers, C Michael; Bush, Mary A; Bush, Peter J; Casadevall, Arturo; Cole, Simon A; Denton, M Bonner; Diamond, Shari Seidman; Dioso-Villa, Rachel; Epstein, Jules; Faigman, David; Faigman, Lisa; Fienberg, Stephen E; Garrett, Brandon L; Giannelli, Paul C; Greely, Henry T; Imwinkelried, Edward; Jamieson, Allan; Kafadar, Karen; Kassirer, Jerome P; Koehler, Jonathan 'Jay'; Korn, David; Mnookin, Jennifer; Morrison, Alan B; Murphy, Erin; Peerwani, Nizam; Peterson, Joseph L; Risinger, D Michael; Sensabaugh, George F; Spiegelman, Clifford; Stern, Hal; Thompson, William C; Wayman, James L; Zabell, Sandy; Zumwalt, Ross E

    2016-12-01

    Several forensic sciences, especially of the pattern-matching kind, are increasingly seen to lack the scientific foundation needed to justify continuing admission as trial evidence. Indeed, several have been abolished in the recent past. A likely next candidate for elimination is bitemark identification. A number of DNA exonerations have occurred in recent years for individuals convicted based on erroneous bitemark identifications. Intense scientific and legal scrutiny has resulted. An important National Academies review found little scientific support for the field. The Texas Forensic Science Commission recently recommended a moratorium on the admission of bitemark expert testimony. The California Supreme Court has a case before it that could start a national dismantling of forensic odontology. This article describes the (legal) basis for the rise of bitemark identification and the (scientific) basis for its impending fall. The article explains the general logic of forensic identification, the claims of bitemark identification, and reviews relevant empirical research on bitemark identification-highlighting both the lack of research and the lack of support provided by what research does exist. The rise and possible fall of bitemark identification evidence has broader implications-highlighting the weak scientific culture of forensic science and the law's difficulty in evaluating and responding to unreliable and unscientific evidence.

  11. Altered Nuclear Functions in Progeroid Syndromes: a Paradigm for Aging Research

    Directory of Open Access Journals (Sweden)

    Baomin Li

    2009-01-01

    Full Text Available Syndromes of accelerated aging could provide an entry point for identifying and dissecting the cellular pathways that are involved in the development of age-related pathologies in the general population. However, their usefulness for aging research has been controversial, as it has been argued that these diseases do not faithfully reflect the process of natural aging. Here we review recent findings on the molecular basis of two progeroid diseases, Werner syndrome (WS and Hutchinson-Gilford progeria syndrome (HGPS, and highlight functional connections to cellular processes that may contribute to normal aging.

  12. Strategic HRM in Building Micro-Foundations of Organizational Knowledge-Based Performance

    DEFF Research Database (Denmark)

    Minbaeva, Dana

    2013-01-01

    Strategic HRM research has a strong potential to further our understanding of how organizational knowledge processes influence performance at various analytical levels. Drawing on ability–motivation–opportunity research and linking it to knowledge sharing behaviors, we discuss the micro......-foundations in the link between strategic HRM practices and knowledge-based organizational performance. We thus describe a research agenda for future micro-foundational research that links strategic HRM and knowledge-based performance....

  13. Theoretical Foundations for Digital Libraries

    CERN Document Server

    Fox, Edward A; Shen, Rao

    2012-01-01

    In 1991, a group of researchers chose the term digital libraries to describe an emerging field of research, development, and practice. Since then, Virginia Tech has had funded research in this area, largely through its Digital Library Research Laboratory. This book is the first in a four book series that reports our key findings and current research investigations. Underlying this book series are five completed dissertations (Gonçalves, Kozievitch, Murthy, Shen, Torres), nine dissertations underway, and many masters theses. These reflect our experience with a long string of prototype or produc

  14. The foundations of diffusion revisited

    Energy Technology Data Exchange (ETDEWEB)

    Milligen, B. P. van; Carreras, B. A.; Sanchez, R.

    2005-07-01

    Fick's Law lies at the basis of the study of particle and heat transport in many fields of physics. The detailed analysis of transport in magnetically confined plasmas has revealed a very rich phenomenology, including some rather unusual behaviour, such as an unexpected scaling of confinement with system size, power degradation, stiff profiles, rapid transient phenomena (cold and heat pulses) and non-local behaviour, and profile peaking during off axis fueling. It has been extremely difficult to capture these phenomena in the standard transport modelling framework, i.e. local Fickian transport. Ad-hoc modifications of the standard transport paradigm have been proposed, but no unified framework has emerged that is capable of reproducing all phenomena. In the present talk, we review the foundations of the diffusive transport paradigm in terms of the Continuous Time Random Walk (CTRW), which is a generalization of standard Brownian motion. Using a simplified one-dimensional single-field model that incorporates a critical gradient mechanism, we will present a number of highly suggestive results, demonstrating that all mentioned phenomena arise in a natural fashion in this type of model. In addition, we discuss the fluid limit and show that the model produces a radially increasing effective diffusion and an inward directed pinch, very similar to the actual situation in confined plasmas. Finally, we will discuss the general relevance of this type of model for a more profound understanding of transport in magnetic confinement systems, while indicating future developments in this line of investigation. (Author)

  15. Philosophical foundations of nursing practice.

    Science.gov (United States)

    1990-06-01

    This chapter examined how nursing has conceived itself historically and how this conception has changed. It is our contention, along with some of the authors discussed, that this issue is of paramount importance in structuring how a nurse responds to a moral dilemma and which obligations have primary or greater weighting. The empirical studies contained or referred to in Holfing et al. and Murphy substantiate that these conceptions do make a determinative difference in how nurses make ethical decisions. How nursing is viewed and its role relationships defined has been variously referred to as model, role conception, or philosophy of nursing. The significant point is that this forms the philosophical foundation of nursing and has profound ethical implications. The now dominant philosophy is that of client advocacy. However, as the articles indicate, ambiguity about just what advocacy entails and misgivings about the direction nursing has taken by those within and outside of nursing do exist. The next chapter presents still more conceptions of client advocacy and problems associated with it.

  16. ELECTRONIC SCHOLARLY PUBLISHING: FOUNDATIONS OF GENETICS

    Energy Technology Data Exchange (ETDEWEB)

    Robert J. Robbins

    2002-11-10

    As the Human Genome Project (HGP) moves toward its successful completion, more and more people have become interested in understanding this project and its results. Since the HGP has significant ethical, legal, and social implications for all citizens, the number of individuals who do, or should wish to become familiar with the project is high. In addition to its importance in the training of professional geneticists, the HGP is of special relevance for undergraduate training in basic biology, and even for high-school and other K-12 education. Understanding the results of HGP research requires a familiarity with the notions of basic genetics. Unlike other disciplines that evolved over centuries, modern genetics began abruptly with the rediscovery of Gregor Mendel's work in 1900. Within a few years, fundamental concepts were elaborated and the foundations of genetics established. Because genetics developed so rapidly in just a few decades after 1900, the literature of that period constitutes a valuable resource even now. It may be read profitably by students and scientists wishing to understand the foundations of their field, as well as by laymen or historians of science. Unfortunately, the early literature is rapidly becoming almost inaccessible. Newer libraries do not hold older journals and even established libraries are moving their materials from that era into hard-to-reach (and impossible to browse) long-term storage in remote warehouses. To be sure, key studies from the early work are discussed in nearly all textbooks, but a comparison of these presentations with the actual literature shows that most textbook treatments have essentially mythologized the early work so that real understanding is lost. There have been several collections of classic works developed over the years (although none lately), but these suffer from the effects of the necessary, but nonetheless pernicious, highly selective sampling that accompanies these projects. Such selectivity

  17. Foundational Forces & Hidden Variables in Technology Commercialization

    Science.gov (United States)

    Barnett, Brandon

    2011-03-01

    The science of physics seems vastly different from the process of technology commercialization. Physics strives to understand our world through the experimental deduction of immutable laws and dependent variables and the resulting macro-scale phenomenon. In comparison, the~goal of business is to make a profit by addressing the needs, preferences, and whims of individuals in a market. It may seem that this environment is too dynamic to identify all the hidden variables and deduct the foundational forces that impact a business's ability to commercialize innovative technologies. One example of a business ``force'' is found in the semiconductor industry. In 1965, Intel co-founder Gordon Moore predicted that the number of transistors incorporated in a chip will approximately double every 24 months. Known as Moore's Law, this prediction has become the guiding principle for the semiconductor industry for the last 40 years. Of course, Moore's Law is not really a law of nature; rather it is the result of efforts by Intel and the entire semiconductor industry. A closer examination suggests that there are foundational principles of business that underlie the macro-scale phenomenon of Moore's Law. Principles of profitability, incentive, and strategic alignment have resulted in a coordinated influx of resources that has driven technologies to market, increasing the profitability of the semiconductor industry and optimizing the fitness of its participants. New innovations in technology are subject to these same principles. So, in addition to traditional market forces, these often unrecognized forces and variables create challenges for new technology commercialization. In this talk, I will draw from ethnographic research, complex adaptive theory, and industry data to suggest a framework with which to think about new technology commercialization. Intel's bio-silicon initiative provides a case study.

  18. Adaptive plasticity model for bucket foundations

    DEFF Research Database (Denmark)

    Ibsen, Lars Bo; Barari, Amin; Larsen, Kim A.

    2014-01-01

    Based on experimental investigations, the literature proposes different methods for modeling the behavior and capacity of foundations subjected to combined loading. Generally, two methods are used to predict the behavior of foundations: traditional approaches and hardening plasticity solutions....... The first method is only capable of determining the capacity of the foundations and not the prepeak behavior. Thus, a new strain-hardening criterion is developed by calibrating failure criteria by employing data from small-scale tests on bucket foundations subjected to static loads. The shape of the yield...

  19. Industrial Foundations in the Tax System

    DEFF Research Database (Denmark)

    Nielsen, Søren Bo

    and elsewhere. This system implies clear consequences for the taxation of different types of income, labor income and capital income. However, as the outline of the system is based on the premise that “people pay taxes”, industrial foundations, having no personal owners, do not immediately fit in. So what to do......This paper attempts to place industrial foundations (IFs in the following; similar to trusts) in the tax system. An industrial foundation is a private foundation that holds a voting majority in a joint stock corporation. These IFs are probably more prevalent in Denmark than in any other country...

  20. Numerical modeling of reinforced foundation pads structures

    Directory of Open Access Journals (Sweden)

    Ponomarev Andrey Budimirovich

    2016-11-01

    Full Text Available The wide use of reinforced foundation pads is complicated because of the absence of technical rules and regulations on design of such structures. It is necessary to investigate the main parameters and regularities of such structures operation under loading. For this aim numerical study of the foundation was carried out, the parameters of which were improved by reinforced foundation pad. The numerical modeling of reinforced foundation pads was carried out in the Plaxis 2D for study of the basic laws and operating parameters and for determination of the application area of these structures. The main goal of this study was to establish the optimal structures of reinforced foundation pads. This goal was achieved by solving the following tasks: determination of the optimal parameters of reinforced foundation pads; study of the stress-strain state of reinforced foundation pads and a soft base; estimation of the load, at which the ultimate settlement is achieved for all types of reinforced foundation pads. It was concluded that the lower reinforcement separating layer allows increasing the loading of the foundation. The typical and optimal reinforcement spacing were specified and analyzed.

  1. Vertical Dynamic Stiffness of Offshore Foundations

    DEFF Research Database (Denmark)

    Latini, Chiara; Cisternino, Michele; Zania, Varvara

    2016-01-01

    Nowadays, pile and suction caisson foundations are widely used to support offshore structures which are subjected to vertical dynamic loads. The dynamic soil-structure interaction of floating foundations (foundations embedded in a soil layer whose height is greater than the foundation length......) is investigated by numerical analyses of representative finite element models. The 3D numerical model is compared and validated with existing analytical solutions. A parametric study is carried out analyzing the effect of the slenderness ratio Hp/d and the height and the stiffness of the soil layer on the dynamic...

  2. Industrial Foundations in the Danish Economy

    DEFF Research Database (Denmark)

    Thomsen, Steen

    -owned companies account for 5-10% of the Danish economy depending on measurement. However, they constitute the bulk of Danish stock market capitalization and R&D expenditure, and they also contribute disproportionally to international business activity. Finally the industrial foundations make charitable donations......Industrial Foundations (foundations that own business companies) are found around the world e.g in Northern Europe, Germany, the US and India, but nowhere do they appear to be as economically important as in Denmark. In this paper we review their share of the Danish economy. We find that foundation...

  3. Teaching for understanding : curriculum guidance for the foundation stage.

    OpenAIRE

    English, E.

    2001-01-01

    This paper briefly considers what research has told us about the development of young children's understanding. It goes on to look at the Curriculum Guidance for the Foundation Stage (QCA, 2000) in terms of that research. The paper suggests that the guidance has addressed concerns that early years practitioners might be delivering an inappropriate curriculum in their attempts to reach targets. The published guidance is giving a clear message that an early years curriculum is quite different f...

  4. A joint study on the research reactor development technology in Brazil, Vietnam, Thailand, etc. and a study on the establishment of basic foundation for the activation of the HANARO technology export

    Energy Technology Data Exchange (ETDEWEB)

    Choi, C. W.; Lee, J. B.; Kim, H. R. [and others

    2003-03-01

    According to the characteristics of this project, the results of the technical cooperation development are the agreed terms, developed items, and others that the one who is conducting a research reactor project, requires from Hanaro specifically.

  5. Density functional theory: Foundations reviewed

    Energy Technology Data Exchange (ETDEWEB)

    Kryachko, Eugene S., E-mail: eugene.kryachko@ulg.ac.be [Bogolyubov Institute for Theoretical Physics, Kiev, 03680 (Ukraine); Ludeña, Eduardo V., E-mail: popluabe@yahoo.es [Centro de Química, Instituto Venezolano de Investigaciones Científicas, IVIC, Apartado 21827, Caracas 1020-A (Venezuela, Bolivarian Republic of); Prometheus Program, Senescyt (Ecuador); Grupo Ecuatoriano para el Estudio Experimental y Teórico de Nanosistemas, GETNano, USFQ, N104-E, Quito (Ecuador); Escuela Politécnica Superior del Litoral, ESPOL, Guayaquil (Ecuador)

    2014-11-10

    Guided by the above motto (quotation), we review a broad range of issues lying at the foundations of Density Functional Theory, DFT, a theory which is currently omnipresent in our everyday computational study of atoms and molecules, solids and nano-materials, and which lies at the heart of modern many-body computational technologies. The key goal is to demonstrate that there are definitely the ways to improve DFT. We start by considering DFT in the larger context provided by reduced density matrix theory (RDMT) and natural orbital functional theory (NOFT), and examine the implications that N-representability conditions on the second-order reduced density matrix (2-RDM) have not only on RDMT and NOFT but, also, by extension, on the functionals of DFT. This examination is timely in view of the fact that necessary and sufficient N-representability conditions on the 2-RDM have recently been attained. In the second place, we review some problems appearing in the original formulation of the first Hohenberg–Kohn theorem which is still a subject of some controversy. In this vein we recall Lieb’s comment on this proof and the extension to this proof given by Pino et al. (2009), and in this context examine the conditions that must be met in order that the one-to-one correspondence between ground-state densities and external potentials remains valid for finite subspaces (namely, the subspaces where all Kohn–Sham solutions are obtained in practical applications). We also consider the issue of whether the Kohn–Sham equations can be derived from basic principles or whether they are postulated. We examine this problem in relation to ab initio DFT. The possibility of postulating arbitrary Kohn–Sham-type equations, where the effective potential is by definition some arbitrary mixture of local and non-local terms, is discussed. We also deal with the issue of whether there exists a universal functional, or whether one should advocate instead the construction of problem

  6. Laboratory Setup for Vertically Loaded Suction Caisson Foundation in Sand and Validation of Responses

    DEFF Research Database (Denmark)

    Manzotti, E.; Vaitkunaite, Evelina; Ibsen, Lars Bo

    devices usually installed in farms, therefore many inexpensive foundations are needed. Suction Bucket foundations are a suitable option for this purpose, but for large scale utilization more research is required, especially for in-service performance. Size of offshore wind turbine has been increasing...... during the last years and, following this trend, design choice will turn into foundation composed of three or four suction bucket foundations, called respectively tripod and tetrapod. Overturning moment in tripod and tetrapod is carried by vertical loading; therefore vertical pull-out capacity is tested...

  7. The Psychology of the Politics of Rape: Political Ideology, Moral Foundations, and Attitudes Toward Rape.

    Science.gov (United States)

    Barnett, Michael D; Hilz, Emily N

    2017-05-01

    Previous research has found that conservatives and liberals emphasize different moral foundations. The purpose of these two studies was to investigate whether moral foundations mediate the relationship between political ideology and attitudes toward rape among U.S. college students. In Study 1, moral foundations fully mediated the relationship between political ideology and rape myth acceptance. Study 2 generally replicated the results of Study 1, with binding foundations demonstrating the most consistent mediating effects. These results suggest that individual differences in moral decision-making may explain the relationship between political ideology and attitudes toward rape.

  8. Laying the Foundations of Contemporary Romanian Astronomy

    Science.gov (United States)

    Marin, Sorin

    2017-11-01

    This article describes the first stage in the history of Romanian astronomy represented by the events, processes and evolution which led to the formation of great scientific personalities, development drives and the creation of the material base for the contemporary Romanian astronomy, having a focus point on the activity of Bucharest Observatory. The article discusses the roots of an evolution pathway determined and inspired by the activity of several scientific personalities of Romania such as Stefan Hepites, Spiru Haret, Nicolae Coculescu and others. It also underlines that a great importance for the astronomical research in Romania was given by the outstanding technical value of the main instruments used at the Observatory in the first decades of activity and, consequentially, by their longevity in service: in the Equatorial Dome - the impressive 6 m. Prin-Mertz telescope and in the Meridian Hall - the GautierPrin telescope. This determined the formation of a powerful astrometry division and a research drive which led over time to important scientific works such as the ultraprecise stellar catalogues developed in Romania at Bucharest Observatory, which were appreciated and awarded nationally and internationally. Therefore, the article includes the moments and the people which determined the success of laying the foundations of the Observatory in 1908 and then having completed the initial scientific infrastructure in 1912 when the construction work was finished, and briefly presents the features, scientific utilisation and outputs of its telescopes, some of the best in the world in their golden years.

  9. Locomotion concerns with moral usefulness: When liberals endorse binding moral foundations.

    Science.gov (United States)

    Cornwell, James F M; Higgins, E Tory

    2014-01-01

    Moral Foundations Theory has provided a framework for understanding the endorsement of different moral beliefs. Our research investigated whether there are other reasons to endorse moral foundations in addition to epistemic concerns; specifically, the perceived social usefulness of moral foundations. In Study 1, we demonstrate that those showing stronger locomotion concerns for controlling movement tend toward a higher endorsement of binding foundations, and that this effect is stronger among political liberals who otherwise do not typically endorse these foundations. In Study 2, we show that priming participants with assessment concerns (emphasizing truth) rather than locomotion concerns (emphasizing control) reduces the response variance among liberals and also removes the association between locomotion and the binding foundations. In Study 3, we directly ask participants to focus on moral truth versus moral usefulness, with moral truth replicating the Study 2 effect of assessment priming, and moral usefulness replicating the effect of locomotion priming.

  10. This New Field of Inclusive Education: Beginning a Dialogue on Conceptual Foundations

    Science.gov (United States)

    Danforth, Scot; Naraian, Srikala

    2015-01-01

    Numerous scholars have suggested that the standard knowledge base of the field of special education is not a suitable intellectual foundation for the development of research, policy, and practice in the field of inclusive education. Still, we have yet to have a dialogue on what conceptual foundations may be most generative for the growth and…

  11. Environmental Education in the Galapagos: 2007 Report to the Charles Darwin Foundation

    Science.gov (United States)

    Stepath, Carl M.

    2007-01-01

    Background: "Environmental education in the Galapagos: 2007 report to the Charles Darwin Foundation" is a report to the Charles Darwin Foundation (CDF) about the researchers observations about the status of environmental education in the Galapagos in 2006 and 2007. Purpose: This paper reports on environmental education in the Galapagos…

  12. Peace Education: Exploring Some Philosophical Foundations

    Science.gov (United States)

    Page, James S.

    2004-01-01

    Peace education has been recognized as an important aspect of social education for the past three decades. The critical literature as well as official documents, however, have given little attention to its philosophical foundations. This essay explores these foundations in the ethics of (1) virtue, (2) consequentialism, (3) aesthetics, (4)…

  13. Vibrations of a pipe on elastic foundations

    Indian Academy of Sciences (India)

    R. Narasimhan (Krishtel eMaging) 1461 1996 Oct 15 13:05:22

    is investigated. Two cases of elastic foundations are considered: rotational and both linear and rotational. The major findings are the variations in frequency with flow velocity and displacements at different points and times. Keywords. Cantilevered pipe; vibrations of pipes; elastic foundations; exter- nal transverse force. 1.

  14. Historical and Conceptual Foundation of Diagrammatical Ontology

    DEFF Research Database (Denmark)

    Øhrstrøm, Peter; Uckelman, Sara L.; Schärfe, Henrik

    2007-01-01

    During the Renaissance there was a growing interest for the use of diagrams within conceptual studies. This paper investigates the historical and philosophical foundation of this renewed use of diagrams in ontology as well as the modern relevance of this foundation. We discuss the historical...

  15. Monopod Bucket Foundations Under Cyclic Lateral Loading

    DEFF Research Database (Denmark)

    Foglia, Aligi; Ibsen, Lars Bo

    2016-01-01

    The monopod bucket foundation has the potential to become a cost-reducing substructure for offshore wind turbines. To avoid problems during the energy converter operation, the long-term effect of cyclic loading must be considered in the design of the foundation. In this paper, a 1-g testing rig...

  16. Monopod bucket foundations under cyclic lateral loading

    DEFF Research Database (Denmark)

    Foglia, Aligi; Ibsen, Lars Bo

    The monopod bucket foundation can be a cost-reducing sub-structure for offshore wind turbines. To avoid problems during the turbine operation, the long-term effect of cyclic loading must be considered in the design of the foundation. In this paper a 1g testing rig is adopted to extend the knowledge...

  17. A behavioral foundation for fuzzy measures

    NARCIS (Netherlands)

    Wakker, P.P.

    1990-01-01

    In Savage (1954) a behavioral foundation was given for subjective probabilities, to be used in the maximization of expected utility. This paper analogously gives a behavioral foundation for fuzzy measures, to be used in the maximization of the Choquet-integral. This opens the way to empirical

  18. Scour and Scour Protection for Windturbine Foundations

    DEFF Research Database (Denmark)

    Larsen, Brian Juul; Frigaard, Peter

    A test programme has been performed to determine the necessary scour protection around a various types of foundation for an offshore windturbine. Furthermore the unprotected scour depths have been investigated.......A test programme has been performed to determine the necessary scour protection around a various types of foundation for an offshore windturbine. Furthermore the unprotected scour depths have been investigated....

  19. Wave Forces on Offshore Windturbine Foundations

    DEFF Research Database (Denmark)

    Larsen, Brian Juul; Frigaard, Peter

    The present report on the wave forces is the first report on the Borkum Riff project. A testprogramme has been performed to dertermine the wave forces on windturbine foundations.......The present report on the wave forces is the first report on the Borkum Riff project. A testprogramme has been performed to dertermine the wave forces on windturbine foundations....

  20. Scour and Scour Protection for Bucket Foundations

    DEFF Research Database (Denmark)

    Larsen, Brian Juul; Frigaard, Peter

    A test programme has been performed to determine the scour around a bucket foundation for an offshore windturbine. furthermore the necessary scour protection has been investigated.......A test programme has been performed to determine the scour around a bucket foundation for an offshore windturbine. furthermore the necessary scour protection has been investigated....