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Sample records for progeny recurrent selection

  1. Phytochemical profile of morphologically selected yerba-mate progenies

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    Alice Teresa Valduga

    2016-02-01

    Full Text Available ABSTRACT Yerba-mate (Ilex paraguariensis St. Hil is a native South American species. Plant progenies are populations that differ in terms of their productivity, morphology and phytochemical profile. This study aimed to determine the concentration of primary and secondary metabolites, such as antioxidants, in leaves, of yerba-mate progenies selected based on morphological characteristics. We evaluated the centesimal composition of secondary metabolites in the leaves of five yerba-mate plants. Methylxanthines and phenolic compounds were determined by UPLC-PDA, and antioxidant activity by measuring DPPH scavenging. Significant differences were found in centesimal composition and the contents of caffeine, theobromine, rutin and chlorogenic acid, as well as antioxidant activities, in selected progenies. The IC50 values were correlated with the chlorogenic acid levels (r2 = 0.5242 and soluble content (r2 = 0.7686. The morphological characteristics observed in yerba-mate leaves can be used as a tool for plant selection, to obtain matrices with different phytochemical profiles as a genetic material source.

  2. Selection of arabica coffee progenies tolerant to heat stress

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    Alexsandro Lara Teixeira

    2015-07-01

    Full Text Available Due to high temperatures, practically all coffee farms in the state of Rondonia are of the C. canephora species. Thus, importing arabica coffee from other states becomes necessary for composition of blends, as well as for the specialty or gourmet coffee market. The purpose of this study was to select arabica coffee genotypes that exhibit satisfactory agronomic performance under high temperature conditions. The experiment was conducted in OuroPreto do Oeste, RO, Brazil, with mean annual temperature of 25.8°C and mean annual rainfall of 2300mm year-1. The experiment was composed of 114 arabica coffee genotypes, with 103 progenies and eleven control cultivars, provided by EPAMIG. A randomized block experimental design was used with three replications, spacing of 3.0x1.0 meters and five plants per plot. All the crop seasons showed significant difference for the green coffee yield trait. In joint analysis, significant differences were detected among progenies and control cultivars. In the average of the four harvests, green coffee yield was 32.38 bags ha-1. The cultivars 'CatuaíVermelho IAC 15', 'Obatã IAC 1669-20' and 'Catucaí Amarelo 2SLCAK' stood out, achieving yields greater than 40 bags ha-1. The gain obtained from selection was 14.33 bags ha-1, which is equivalent to an increase of 44.04% in production of green coffee. The progeny H514-7-10-6-2-3-9 stood out with an average yield of 51.20 bags ha-1. In regard to maturation cycle, 56% of the progenies were classified as early maturity and 44% as medium maturity. Late maturity genotypes were not observed

  3. Selection of inbred maize (Zea mays L.) progenies by topcrosses conducted in contrasting environments.

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    Rodrigues, C S; Pacheco, C A P; Guedes, M L; Pinho, R G V; Castro, C R

    2016-09-23

    The aim of this study was to identify inbred progenies of S 0:1 maize (Zea mays L.) plants that were efficient at a low level of technology and responsive at a high level of technology through the use of topcrosses. Two contrasting environments were created using two levels of base fertilization and topdressing, so that the levels of nitrogen, phosphorus, and potassium were applied four times higher in one environment than in the other. We used S 0:1 progenies derived from commercial hybrids in topcrosses with two testers (an elite line from the flint heterotic group and an elite line from the dent heterotic group). The progenies and three controls were evaluated in an augmented block design in Nossa Senhora das Dores, SE, Brazil in the 2010 crop season. The average grain yield in the high-technological level was 21.44% greater than that in the low-technological level. There were no changes in progeny behavior in the two technological levels for grain yield. The testers did not differ in the average grain yield of the progenies at the two technological levels. Therefore, it is possible to select progenies derived from commercial hybrids that have an efficient response to fertilization.

  4. Improvement in genetic characteristics and oil yield of selected soybean progenies from octuple crosses

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    Hamawaki Osvaldo Toshiyuki

    2000-01-01

    Full Text Available The objective of the present study was to evaluate 44 soybean octuple crosses in the F4:3[8] and F5:3[8] generations in order to select progenies superior for seed oil yield (OY and other important agronomic characteristics. Octuple crosses were hybridized in a chain mating system. In one group, crosses were carried out for three generations with the adapted x exotic parents until octuple crosses with 75% adapted genes and 25% exotic genes were obtained. In a second group, hybridization of adapted x adapted parents originated crosses with 100% adapted genes. During the growing season 1994/95, the progenies F4:3[8] were evaluated by using the augmented block design. The progenies F5:3[8] were evaluated during the growing season 1995/96 in three experiments using augmented block design without repetition. The octuple crosses gave origin to superior progenies for all the characters studied. In the C22 cross, OY values were 707 kg/ha. The estimates of heritability in relation to the crosses average resulted in the following mean, minimum and maximum values, respectively: number of days to maturity (52.35%, 3.71%, 84.23%; agronomic value (26.69%, 1.62%, 61.28% and grain yield (29.28%, 1.52%, 61.06%. The observed genetic gains for grain yield in the early, intermediate and late F5:3[8] progenies were superior to the expected genetic gains and the observed genetic gains for OY were more expressive in the early and late F5:[8] progenies. The genetic variability remaining in the selected progenies of some crosses suggests that further genetic gains for grain yield and OY might be possible with advanced selection cycles.

  5. Increasing the resistance of common bean to white mold through recurrent selection

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    Monik Evelin Leite

    2016-02-01

    Full Text Available ABSTRACT White mold, caused by Sclerotinea sclerotiorum (Lib. de Bary is one of the most important diseases of the common bean (Phaseolus vulgaris L. worldwide. Physiological resistance and traits related to disease avoidance such as architecture contribute to field resistance. The aim of this study was to verify the efficiency of recurrent selection in physiological resistance to white mold, “Carioca” grain type and upright habit in common bean. Thirteen common bean lines with partial resistance to white mold were intercrossed by means of a circulant diallel table, and seven recurrent selection cycles were obtained. Of these cycles, progenies of the S0:1, S0:2 and S0:3 generations of cycles III, IV, V and VI were evaluated. The best (8 to 10 progenies of the seven cycles were also evaluated, in two experiments, one in the greenhouse and one in the field. Lattice and/or randomized block experimental designs were used. The traits evaluated were: resistance to white mold by the straw test method, growth habit and grain type. The most resistant progenies were selected based on the average score of resistance to white mold. Subsequently, they were evaluated with regard to grain type and growth habit. Recurrent selection allowed for genetic progress of about 11 % per year for white mold resistance and about 15 % per year for the plant architecture. There was no gain among cycles for grain type. Progeny selection and recurrent selection were efficient for obtaining progenies with a high level of resistance to white mold with “Carioca” grain type and upright habit.

  6. A study on genetic variation and selective effect of principal characters of hybrid progenies of macro-mutants in peanut

    International Nuclear Information System (INIS)

    Qiu Qingrong

    1990-01-01

    In order to make good use of macro-mutants, we have studied the law of genetic variation and selective effect on the hybrid progenies of original varieties and of two macro-mutants with steady phenotypes. The results show that the hybrid progenies of the two experimental macro-mutants in the broad-sense heritability and the genetic advance of their main economical characters as well as the effect on selection are better than those of the hybrid progenies of the two original varieties. The selection rate from the macro-mutant hybrid progenies is 72.2% which is higher than that of the hybrid progenies of the two original varieties, and and a new prospecting strain has been obtained

  7. Repeatability and number of growing seasons for the selection of custard apple progenies

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    Julio César Do Vale

    2011-01-01

    Full Text Available This study aimed to estimate the repeatability coefficient and determine the minimum number of samplesrequired for effective selection for yield of custard apple. Twenty progenies were evaluated in randomized blocks, fivereplications and four plants per plot. The fruits were collected, counted and weighed every two days of the year. Estimates ofthe repeatability coefficients were obtained by the methods of analysis of variance - ANOVA and principal components - PC.The estimates from the repeatability analysis of biennial data are higher than those based on individual years. The estimatesof the PC method were accurate even in the first harvest, unlike ANOVA. Four biennia were sufficient to ensure effectiveprogeny selection of custard apple.

  8. Continuous progeny testing, use and selection of proven bulls in Israel

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    R. Bar-Anan

    1983-12-01

    Full Text Available The breeding policy of the Israeli Holstein-type dairy cattle is reviewed. The bulls are progeny tested on their daughters’ first three lactations. The traits evaluated are the following: milk, fat, yield persistency, fertility, incidence of mastitis, and % cullings for three most important reasons. The test analysis takes into account the genetic level of daughters’ contemporaries and maternal grandsires. The paper describes a general outline of the selection decisions in AI bulls. Considerable amount of imported semen is used for breeding young bulls. Breeding goals are discussed against the estimated genetic parameters for and between the given traits.

  9. ARTICLE - Inbreeding depression in castor bean (Ricinus communis L. progenies

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    Milton Krieger

    2012-12-01

    Full Text Available The purpose of this study was to investigate inbreeding depression (DE in castor bean. From a population derived from the Guarani cultivar, 60 mother plants were sampled. Three types of progenies were obtained from each one: from self-pollination (AU, from crosses (CR and from open pollination (PL. Grain yield of the progenies was evaluated in two locations. There was a strong interaction of progenies x locations, which led to obtaining estimates within each location. Broad variation was observed in inbreeding depression, with mean values of 6.7% and 13.4%, comparing AU progenies with PL progenies. It was observed that the population has high potential for selecting promising inbred lines. The frequency of mother plants generating progenies with simultaneous high general combination capacity and low inbreeding depression was low. Recurrent selection will increase the occurrence of parent plants associating these two properties, which is necessary for obtaining superior synthetic varieties.

  10. Divergent clonal selection dominates medulloblastoma at recurrence

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    Morrissy, A. Sorana; Garzia, Livia; Shih, David J. H.; Zuyderduyn, Scott; Huang, Xi; Skowron, Patryk; Remke, Marc; Cavalli, Florence M. G.; Ramaswamy, Vijay; Lindsay, Patricia E.; Jelveh, Salomeh; Donovan, Laura K.; Wang, Xin; Luu, Betty; Zayne, Kory; Li, Yisu; Mayoh, Chelsea; Thiessen, Nina; Mercier, Eloi; Mungall, Karen L.; Ma, Yusanne; Tse, Kane; Zeng, Thomas; Shumansky, Karey; Roth, Andrew J. L.; Shah, Sohrab; Farooq, Hamza; Kijima, Noriyuki; Holgado, Borja L.; Lee, John J. Y.; Matan-Lithwick, Stuart; Liu, Jessica; Mack, Stephen C.; Manno, Alex; Michealraj, K. A.; Nor, Carolina; Peacock, John; Qin, Lei; Reimand, Juri; Rolider, Adi; Thompson, Yuan Y.; Wu, Xiaochong; Pugh, Trevor; Ally, Adrian; Bilenky, Mikhail; Butterfield, Yaron S. N.; Carlsen, Rebecca; Cheng, Young; Chuah, Eric; Corbett, Richard D.; Dhalla, Noreen; He, An; Lee, Darlene; Li, Haiyan I.; Long, William; Mayo, Michael; Plettner, Patrick; Qian, Jenny Q.; Schein, Jacqueline E.; Tam, Angela; Wong, Tina; Birol, Inanc; Zhao, Yongjun; Faria, Claudia C.; Pimentel, José; Nunes, Sofia; Shalaby, Tarek; Grotzer, Michael; Pollack, Ian F.; Hamilton, Ronald L.; Li, Xiao-Nan; Bendel, Anne E.; Fults, Daniel W.; Walter, Andrew W.; Kumabe, Toshihiro; Tominaga, Teiji; Collins, V. Peter; Cho, Yoon-Jae; Hoffman, Caitlin; Lyden, David; Wisoff, Jeffrey H.; Garvin, James H.; Stearns, Duncan S.; Massimi, Luca; Schüller, Ulrich; Sterba, Jaroslav; Zitterbart, Karel; Puget, Stephanie; Ayrault, Olivier; Dunn, Sandra E.; Tirapelli, Daniela P. C.; Carlotti, Carlos G.; Wheeler, Helen; Hallahan, Andrew R.; Ingram, Wendy; MacDonald, Tobey J.; Olson, Jeffrey J.; Van Meir, Erwin G.; Lee, Ji-Yeoun; Wang, Kyu-Chang; Kim, Seung-Ki; Cho, Byung-Kyu; Pietsch, Torsten; Fleischhack, Gudrun; Tippelt, Stephan; Ra, Young Shin; Bailey, Simon; Lindsey, Janet C.; Clifford, Steven C.; Eberhart, Charles G.; Cooper, Michael K.; Packer, Roger J.; Massimino, Maura; Garre, Maria Luisa; Bartels, Ute; Tabori, Uri; Hawkins, Cynthia E.; Dirks, Peter; Bouffet, Eric; Rutka, James T.; Wechsler-Reya, Robert J.; Weiss, William A.; Collier, Lara S.; Dupuy, Adam J.; Korshunov, Andrey; Jones, David T. W.; Kool, Marcel; Northcott, Paul A.; Pfister, Stefan M.; Largaespada, David A.; Mungall, Andrew J.; Moore, Richard A.; Jabado, Nada; Bader, Gary D.; Jones, Steven J. M.; Malkin, David; Marra, Marco A.; Taylor, Michael D.

    2016-01-01

    The development of targeted anti-cancer therapies through the study of cancer genomes is intended to increase survival rates and decrease treatment-related toxicity. We treated a transposon–driven, functional genomic mouse model of medulloblastoma with ‘humanized’ in vivo therapy (microneurosurgical tumour resection followed by multi-fractionated, image-guided radiotherapy). Genetic events in recurrent murine medulloblastoma exhibit a very poor overlap with those in matched murine diagnostic samples (sequencing of 33 pairs of human diagnostic and post-therapy medulloblastomas demonstrated substantial genetic divergence of the dominant clone after therapy (recurrence). In both mice and humans, the dominant clone at recurrence arose through clonal selection of a pre-existing minor clone present at diagnosis. Targeted therapy is unlikely to be effective in the absence of the target, therefore our results offer a simple, proximal, and remediable explanation for the failure of prior clinical trials of targeted therapy. PMID:26760213

  11. Recurrent selection in inbred popcorn families

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    Daros Máskio

    2004-01-01

    Full Text Available Although much appreciated in Brazil, commercial popcorn is currently cropped on a fairly small scale. A number of problems need to be solved to increase production, notably the obtaintion of seeds with good agronomic traits and good culinary characteristics. With the objective of developing superior genotypes in popcorn, a second cycle of intrapopulation recurrent selection based on inbred S1 families was carried out. From the first cycle of selection over the UNB-2U population, 222 S1 families were obtained, which were then divided into six sets and evaluated in a randomized complete block design with two replications within the sets. Experiments were carried out in two Brazilian localities. The analysis of variance revealed environmental effects for all evaluated traits, except popping and stand, showing that, for most traits, these environments affected genotype behavior in different ways. In addition, the set as source of variation was significant for most of the evaluated traits, indicating that dividing the families into sets was an efficient strategy. Genotype-by-environment interaction was detected for most traits, except popping expansion and stand. Differences among genotypes were also detected (1% F-test, making viable the proposition of using the genetic variability in the popcorn population as a basis for future recurrent selection cycles. Superior families were selected using the Smith and Hazel classic index, with predicted genetic gains of 17.8% for popping expansion and 26.95% for yield.

  12. Late Maturation Steps Preceding Selective Nuclear Export and Egress of Progeny Parvovirus.

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    Wolfisberg, Raphael; Kempf, Christoph; Ros, Carlos

    2016-06-01

    Although the mechanism is not well understood, growing evidence indicates that the nonenveloped parvovirus minute virus of mice (MVM) may actively egress before passive release through cell lysis. We have dissected the late maturation steps of the intranuclear progeny with the aims of confirming the existence of active prelytic egress and identifying critical capsid rearrangements required to initiate the process. By performing anion-exchange chromatography (AEX), we separated intranuclear progeny particles by their net surface charges. Apart from empty capsids (EC), two distinct populations of full capsids (FC) arose in the nuclei of infected cells. The earliest population of FC to appear was infectious but, like EC, could not be actively exported from the nucleus. Further maturation of this early population, involving the phosphorylation of surface residues, gave rise to a second, late population with nuclear export potential. While capsid surface phosphorylation was strictly associated with nuclear export capacity, mutational analysis revealed that the phosphoserine-rich N terminus of VP2 (N-VP2) was dispensable, although it contributed to passive release. The reverse situation was observed for the incoming particles, which were dephosphorylated in the endosomes. Our results confirm the existence of active prelytic egress and reveal a late phosphorylation event occurring in the nucleus as a selective factor for initiating the process. In general, the process of egress of enveloped viruses is active and involves host cell membranes. However, the release of nonenveloped viruses seems to rely more on cell lysis. At least for some nonenveloped viruses, an active process before passive release by cell lysis has been reported, although the underlying mechanism remains poorly understood. By using the nonenveloped model parvovirus minute virus of mice, we could confirm the existence of an active process of nuclear export and further characterize the associated capsid

  13. Selection and genetic gains for juvenile traits in progenies of Hevea in São Paulo State, Brazil

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    Paulo de Souza Gonçalves

    2004-01-01

    Full Text Available Five yield traits were investigated in three-year-old progenies from open-pollinated rubber trees [Hevea brasiliensis (Willd. ex Adr. de Juss Muell.-Arg.]. Twenty progenies were evaluated in a randomized, complete block design replicated three times using 10 plants per linear plot at the North Central Experimental Station in Pindorama, São Paulo State, Brazil. The characters evaluated included the average yield of rubber, growth vigor, bark thickness, total number of latex vessel rings and latex vessel size. Highly significant (p were 37%, 35%, 69%, 10% and 16%, respectively. Significant positive genotypic and phenotypic correlations were found between the yield of rubber and growth vigor (r g = 0.73, r p = 0.70, bark thickness (r g = 0.70**, r p = 0.75** and the total number of latex vessel rings (r g = 0.64, r p = 0.80. There was no relationship between yield and latex vessel size, growth vigor or total number of latex vessel rings. Based on these data, selecting the best two out of 20 progenies would result in a genetic gain of 12.3% and 6.8% for yield of rubber and growth vigor, respectively. The two best individual ortets within each progeny would result in a genetic gain of 27.7% and 9.1%, with a total gain of 40% and 16% for these two traits, respectively.

  14. The possibility of recurrent selection to increase the oil content in soybeans using genetic male sterility and NMR spectroscopy; Possibilidade de selecao recorrente para aumento do teor de oleo em soja com a utilizacao da macho-esterilidade genetica e da espectroscopia de ressonancia nuclear magnetica

    Energy Technology Data Exchange (ETDEWEB)

    Miranda, M A.C. de; Teixeira, J P.F.; Mascarenhas, H A.A. [Instituto Agronomico de Campinas, SP (Brazil); Rettori, C [Universidade Estadual de Campinas, SP (Brazil). Inst. de Fisica

    1990-12-31

    The seed oil content of male sterile plants and their progenies was analysed by a NMR spectroscope to study the possibility of recurrent selection to improve the oil content. The results suggest the possibility of recurrent selection in the composite IAC-1 both in the field with male sterile plants or at the greenhouse when selection is based on average values of progenies. 30 refs., 3 figs., 3 tabs.

  15. Selecting elephant grass families and progenies to produce bioenergy through mixed models (REML/BLUP).

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    Rodrigues, E V; Daher, R F; Dos Santos, A; Vivas, M; Machado, J C; Gravina, G do A; de Souza, Y P; Vidal, A K; Rocha, A Dos S; Freitas, R S

    2017-05-18

    Brazil has great potential to produce bioenergy since it is located in a tropical region that receives high incidence of solar energy and presents favorable climatic conditions for such purpose. However, the use of bioenergy in the country is below its productivity potential. The aim of the current study was to select full-sib progenies and families of elephant grass (Pennisetum purpureum S.) to optimize phenotypes relevant to bioenergy production through mixed models (REML/BLUP). The circulating diallel-based crossing of ten elephant grass genotypes was performed. An experimental design using the randomized block methodology, with three repetitions, was set to assess both the hybrids and the parents. Each plot comprised 14-m rows, 1.40 m spacing between rows, and 1.40 m spacing between plants. The number of tillers, plant height, culm diameter, fresh biomass production, dry biomass rate, and the dry biomass production were assessed. Genetic-statistical analyses were performed through mixed models (REML/BLUP). The genetic variance in the assessed families was explained through additive genetic effects and dominance genetic effects; the dominance variance was prevalent. Families such as Capim Cana D'África x Guaçu/I.Z.2, Cameroon x Cuba-115, CPAC x Cuba-115, Cameroon x Guaçu/I.Z.2, and IAC-Campinas x CPAC showed the highest dry biomass production. The family derived from the crossing between Cana D'África and Guaçu/I.Z.2 showed the largest number of potential individuals for traits such as plant height, culm diameter, fresh biomass production, dry biomass production, and dry biomass rate. The individual 5 in the family Cana D'África x Guaçu/I.Z.2, planted in blocks 1 and 2, showed the highest dry biomass production.

  16. Engineered Dwarf Male-Sterile Rice: A Promising Genetic Tool for Facilitating Recurrent Selection in Rice.

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    Ansari, Afsana; Wang, Chunlian; Wang, Jian; Wang, Fujun; Liu, Piqing; Gao, Ying; Tang, Yongchao; Zhao, Kaijun

    2017-01-01

    Rice is a crop feeding half of the world's population. With the continuous raise of yield potential via genetic improvement, rice breeding has entered an era where multiple genes conferring complex traits must be efficiently manipulated to increase rice yield further. Recurrent selection is a sound strategy for manipulating multiple genes and it has been successfully performed in allogamous crops. However, the difficulties in emasculation and hand pollination had obstructed efficient use of recurrent selection in autogamous rice. Here, we report development of the dwarf male-sterile rice that can facilitate recurrent selection in rice breeding. We adopted RNAi technology to synergistically regulate rice plant height and male fertility to create the dwarf male-sterile rice. The RNAi construct pTCK-EGGE, targeting the OsGA20ox2 and OsEAT1 genes, was constructed and used to transform rice via Agrobacterium -mediated transformation. The transgenic T0 plants showing largely reduced plant height and complete male-sterile phenotypes were designated as the dwarf male-sterile plants. Progenies of the dwarf male-sterile plants were obtained by pollinating them with pollens from the wild-type. In the T1 and T2 populations, half of the plants were still dwarf male-sterile; the other half displayed normal plant height and male fertility which were designated as tall and male-fertile plants. The tall and male-fertile plants are transgene-free and can be self-pollinated to generate new varieties. Since emasculation and hand pollination for dwarf male-sterile rice plants is no longer needed, the dwarf male-sterile rice can be used to perform recurrent selection in rice. A dwarf male-sterile rice-based recurrent selection model has been proposed.

  17. Responses to two-way selection on growth in mass-spawned F1 progeny of Argopecten irradians concentricus (Say)

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    Wang, Hui; Liu, Jin; Li, Yanhong; Zhu, Xiaowen; Liu, Zhigang

    2014-03-01

    In the present study, the effect of one-generation divergent selection on the growth and survival of the bay scallop ( Argopecten irradians concentricus) was examined to evaluate the efficacy of a selection program currently being carried out in Beibu Bay in the South China Sea. A total of 146 adult scallops were randomly selected from the same cultured population of A. i. concentricus, and divided into two groups in shell length (anterior-posterior measurement): large (4.91-6.02 cm, n=74) and small (3.31-4.18 cm, n=72). At the same time, a control group was also randomly sampled (4.21-4.88 cm, n =80). Mass-spawned F 1 progenies from the three size groups were obtained and reared under identical conditions at all growth phases. The effects of two-way (or upward-downward) selection on fertilization rate, hatching rate, survival rate, daily growth in shell length and body weight were assessed in the three size groups. Results show that significant differences ( Pfertilization rate ( P>0.05), among the three groups. The hatching rate, survival rate and daily growth of the progeny of large-sized parents were greater than those of the control group ( Pbody weight were 0.32 ± 0.04 cm and 2.18 ± 0.05 g, respectively, for the upward selection, and -0.14 ± 0.03 cm and -2.77 ± 0.06 g, respectively, for the downward selection. The realized heritability estimates of shell length and body weight were 0.38 ± 0.06 cm and 0.22 ± 0.07 g for the upward selection, and 0.24 ± 0.06 cm and 0.37 ± 0.09 g for the downward selection, respectively. The change in growth by bidirectional selection suggests that high genetic variation may be present in the cultured bay scallop population in China.

  18. Recurrent selection as breeding strategy for heat tolerance in wheat

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    Juarez Campolina Machado

    2010-01-01

    Full Text Available The development of heat-tolerant varieties is an important goal of wheat breeding programs, requiringefficient selection methods. In the present study the use of recurrent selection was evaluated as a strategy to improve heatstress tolerance in wheat. Two cycles of recurrent selection were performed in experiments conducted in research areas of theUniversidade Federal de Viçosa, located in Coimbra-MG and Viçosa-MG, in 2004 and 2007, in two growing seasons (summerand winter. The genetic gain and the existence of variability show the possibility of successful recurrent selection for heattolerancein wheat.

  19. Dominance of highly divergent feline leukemia virus A progeny variants in a cat with recurrent viremia and fatal lymphoma

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    Bauer-Pham Kim

    2010-02-01

    Full Text Available Abstract Background In a cat that had ostensibly recovered from feline leukemia virus (FeLV infection, we observed the reappearance of the virus and the development of fatal lymphoma 8.5 years after the initial experimental exposure to FeLV-A/Glasgow-1. The goals of the present study were to investigate this FeLV reoccurrence and molecularly characterize the progeny viruses. Results The FeLV reoccurrence was detected by the presence of FeLV antigen and RNA in the blood and saliva. The cat was feline immunodeficiency virus positive and showed CD4+ T-cell depletion, severe leukopenia, anemia and a multicentric monoclonal B-cell lymphoma. FeLV-A, but not -B or -C, was detectable. Sequencing of the envelope gene revealed three FeLV variants that were highly divergent from the virus that was originally inoculated (89-91% identity to FeLV-A/Glasgow-1. In the long terminal repeat 31 point mutations, some previously described in cats with lymphomas, were detected. The FeLV variant tissue provirus and viral RNA loads were significantly higher than the FeLV-A/Glasgow-1 loads. Moreover, the variant loads were significantly higher in lymphoma positive compared to lymphoma negative tissues. An increase in the variant provirus blood load was observed at the time of FeLV reoccurrence. Conclusions Our results demonstrate that ostensibly recovered FeLV provirus-positive cats may act as a source of infection following FeLV reactivation. The virus variants that had largely replaced the inoculation strain had unusually heavily mutated envelopes. The mutations may have led to increased viral fitness and/or changed the mutagenic characteristics of the virus.

  20. Estimates for Genetic Variance Components in Reciprocal Recurrent Selection in Populations Derived from Maize Single-Cross Hybrids

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    Matheus Costa dos Reis

    2014-01-01

    Full Text Available This study was carried out to obtain the estimates of genetic variance and covariance components related to intra- and interpopulation in the original populations (C0 and in the third cycle (C3 of reciprocal recurrent selection (RRS which allows breeders to define the best breeding strategy. For that purpose, the half-sib progenies of intrapopulation (P11 and P22 and interpopulation (P12 and P21 from populations 1 and 2 derived from single-cross hybrids in the 0 and 3 cycles of the reciprocal recurrent selection program were used. The intra- and interpopulation progenies were evaluated in a 10×10 triple lattice design in two separate locations. The data for unhusked ear weight (ear weight without husk and plant height were collected. All genetic variance and covariance components were estimated from the expected mean squares. The breakdown of additive variance into intrapopulation and interpopulation additive deviations (στ2 and the covariance between these and their intrapopulation additive effects (CovAτ found predominance of the dominance effect for unhusked ear weight. Plant height for these components shows that the intrapopulation additive effect explains most of the variation. Estimates for intrapopulation and interpopulation additive genetic variances confirm that populations derived from single-cross hybrids have potential for recurrent selection programs.

  1. Attention-based Memory Selection Recurrent Network for Language Modeling

    OpenAIRE

    Liu, Da-Rong; Chuang, Shun-Po; Lee, Hung-yi

    2016-01-01

    Recurrent neural networks (RNNs) have achieved great success in language modeling. However, since the RNNs have fixed size of memory, their memory cannot store all the information about the words it have seen before in the sentence, and thus the useful long-term information may be ignored when predicting the next words. In this paper, we propose Attention-based Memory Selection Recurrent Network (AMSRN), in which the model can review the information stored in the memory at each previous time ...

  2. Recurrent selection as breeding strategy for heat tolerance in wheat

    OpenAIRE

    Juarez Campolina Machado; Moacil Alves de Souza; Davi Melo de Oliveira; Adeliano Cargnin; Aderico Júnior Badaró Pimentel; Josiane Cristina de Assis

    2010-01-01

    The development of heat-tolerant varieties is an important goal of wheat breeding programs, requiringefficient selection methods. In the present study the use of recurrent selection was evaluated as a strategy to improve heatstress tolerance in wheat. Two cycles of recurrent selection were performed in experiments conducted in research areas of theUniversidade Federal de Viçosa, located in Coimbra-MG and Viçosa-MG, in 2004 and 2007, in two growing seasons (summerand winter). The genetic gain ...

  3. [Selective neck dissection for treating recurrent branchial anomalies].

    Science.gov (United States)

    Chen, Liangsi; Song, Xinhan; Zhang, Siyi; Han, Zhijuan; Luo, Xiaoning; Chen, Shaohua; Zhan, Jiandong

    2011-01-01

    To evaluate the role of selective neck dissection in the treatment of recurrent branchial anomalies. The clinical data of 18 patients with recurrent branchial anomalies were retrospectively analyzed. In accordance with the embryologic and anatomic features of branchial anomalies, different types of selective neck dissection were applied. With dissection and protection of important vessels, nerves and other structures, enbloc resection principles were applied to extirpate branchial lesions, scarrings and inflammatory granuloma during the operation. Of all 18 patients, 16 cases were healed with primary healing, 2 cases with local incision infection were healed after dressing changes. A temporary facial nerve paralysis occurred in 1 case with recurrent first branchial cleft fistula postoperatively, and completely recovered 2 months after operation. A postoperative temporary vocal cord paralysis occurred in 1 case with recurrent fourth branchial cleft fistula, and totally recuperated 1 month after operation. No recurrences were found in all 18 cases with a follow-up period of 12-78 months (average 35 months). Selective neck dissection is a safe and effective surgical procedure for the radical treatment of recurrent branchial anomalies.

  4. Detecting negative selection on recurrent mutations using gene genealogy

    Science.gov (United States)

    2013-01-01

    Background Whether or not a mutant allele in a population is under selection is an important issue in population genetics, and various neutrality tests have been invented so far to detect selection. However, detection of negative selection has been notoriously difficult, partly because negatively selected alleles are usually rare in the population and have little impact on either population dynamics or the shape of the gene genealogy. Recently, through studies of genetic disorders and genome-wide analyses, many structural variations were shown to occur recurrently in the population. Such “recurrent mutations” might be revealed as deleterious by exploiting the signal of negative selection in the gene genealogy enhanced by their recurrence. Results Motivated by the above idea, we devised two new test statistics. One is the total number of mutants at a recurrently mutating locus among sampled sequences, which is tested conditionally on the number of forward mutations mapped on the sequence genealogy. The other is the size of the most common class of identical-by-descent mutants in the sample, again tested conditionally on the number of forward mutations mapped on the sequence genealogy. To examine the performance of these two tests, we simulated recurrently mutated loci each flanked by sites with neutral single nucleotide polymorphisms (SNPs), with no recombination. Using neutral recurrent mutations as null models, we attempted to detect deleterious recurrent mutations. Our analyses demonstrated high powers of our new tests under constant population size, as well as their moderate power to detect selection in expanding populations. We also devised a new maximum parsimony algorithm that, given the states of the sampled sequences at a recurrently mutating locus and an incompletely resolved genealogy, enumerates mutation histories with a minimum number of mutations while partially resolving genealogical relationships when necessary. Conclusions With their

  5. Progeny reproduction

    International Nuclear Information System (INIS)

    Mashneva, N.I.

    1984-01-01

    Studies on clarification of importance of different harmful factors of radiation and chemical nature on the function of progeny reproduction, growth and development are presented. Intake of radionuclides to organism, of white mices and rats in concentrations corresponding to 10 6 PCsub(s) ( 90 Sr, 210 Po, 210 Pb and other) is shown to result in 100% sterility of females, 10 5 -10 4 PCsub(s) concentrations cause damaging effect of different degrees of expression at later stages of effect. Smaller contents of radionuclides (10 3 -10 2 PCsub(s)) did not result in noticeable changes in reproductivity of animals. Similar regularities were observed under effect of different concentrations of chemical agent. Some peculiarities of animal physiology should be taken into account to obtain data of estimation of damaging effect of harmful factors on reproduction function

  6. Isoenzymatic variability in tropical maize populations under reciprocal recurrent selection

    Directory of Open Access Journals (Sweden)

    Pinto Luciana Rossini

    2003-01-01

    Full Text Available Maize (Zea mays L. is one of the crops in which the genetic variability has been extensively studied at isoenzymatic loci. The genetic variability of the maize populations BR-105 and BR-106, and the synthetics IG-3 and IG-4, obtained after one cycle of a high-intensity reciprocal recurrent selection (RRS, was investigated at seven isoenzymatic loci. A total of twenty alleles were identified, and most of the private alleles were found in the BR-106 population. One cycle of reciprocal recurrent selection (RRS caused reductions of 12% in the number of alleles in both populations. Changes in allele frequencies were also observed between populations and synthetics, mainly for the Est 2 locus. Populations presented similar values for the number of alleles per locus, percentage of polymorphic loci, and observed and expected heterozygosities. A decrease of the genetic variation values was observed for the synthetics as a consequence of genetic drift effects and reduction of the effective population sizes. The distribution of the genetic diversity within and between populations revealed that most of the diversity was maintained within them, i.e. BR-105 x BR-106 (G ST = 3.5% and IG-3 x IG-4 (G ST = 4.0%. The genetic distances between populations and synthetics increased approximately 21%. An increase in the genetic divergence between the populations occurred without limiting new selection procedures.

  7. Functional molecular markers (EST-SSR) in the full-sib reciprocal recurrent selection program of maize (Zea mays L.).

    Science.gov (United States)

    Galvão, K S C; Ramos, H C C; Santos, P H A D; Entringer, G C; Vettorazzi, J C F; Pereira, M G

    2015-07-03

    This study aimed to improve grain yield in the full-sib reciprocal recurrent selection program of maize from the North Fluminense State University. In the current phase of the program, the goal is to maintain, or even increase, the genetic variability within and among populations, in order to increase heterosis of the 13th cycle of reciprocal recurrent selection. Microsatellite expressed sequence tags (EST-SSRs) were used as a tool to assist the maximization step of genetic variability, targeting the functional genome. Eighty S1 progenies of the 13th recur-rent selection cycle, 40 from each population (CIMMYT and Piranão), were analyzed using 20 EST-SSR loci. Genetic diversity, observed heterozygosity, information content of polymorphism, and inbreeding co-efficient were estimated. Subsequently, analysis of genetic dissimilarity, molecular variance, and a graphical dispersion of genotypes were conducted. The number of alleles in the CIMMYT population ranged from 1 to 6, while in the Piranão population the range was from 2 to 8, with a mean of 3.65 and 4.35, respectively. As evidenced by the number of alleles, the Shannon index showed greater diversity for the Piranão population (1.04) in relation to the CIMMYT population (0.89). The genic SSR markers were effective in clustering genotypes into their respective populations before selection and an increase in the variation between populations after selection was observed. The results indicate that the study populations have expressive genetic diversity, which cor-responds to the functional genome, indicating that this strategy may contribute to genetic gain, especially in association with the grain yield of future hybrids.

  8. Selection of wheat subpopulations obtained by recurrent radiation

    International Nuclear Information System (INIS)

    Morales Gomez Jose Antonio; Cervantes Santana Tarcicio

    1990-01-01

    The purpose of this study was the analysis of the effect of one cycle of divergent selection for number of tillers per plant, in subpopulations M1 to M4 after each of six cycles of radiation of seed of wheat (Triticum aestivum L.) var. Salamanca S-75 with gamma rays. Irradiated materials and the original variety were field evaluated under two seeding densities. Results varied significantly for the two seeding densities. The 5 kr recurrent dose of radiation caused first a decrease in the number of tillers per plant and then an increase; doses of 20 and 40 kr were lethal in the fifth time of radiation, and 60 kr were lethal at the second radiation time. One cycle of divergent selection was more effective for more tillers per plant in the radiated subpopulations than in the original variety showing at the same time, an increase in the number of tillers as the number of generations of segregation (M) increased for the first four radiations [es

  9. Development of a portable radon progeny monitor

    International Nuclear Information System (INIS)

    Iimoto, Takeshi; Kosako, Toshiso; Sugiura, Nobuyuki

    2000-01-01

    Important nuclides in the radon family contributing to the effective dose are the members of the radon short-life progeny, 218 Po and 214 Po and direct measurement of these progenies is suitable for dosimetry. Survey of the radon progeny concentrations in a number of dwellings and offices is very difficult because we have no convenient instrument for the measurement. At present, radon dosimetry is carried out based on the concentration of the parent radon itself. Therefore, for accurate estimation of public or personal effective dose, it is necessary to develop a facile and portable radon progeny monitor. In this study, a portable radon progeny monitor (PRPM) was designed and developed to automatically estimate the individual progeny concentration in the natural environment. The properties of PRPM were investigated. The dimensions of the entire instrument were 65 x 145 x 170 mm and the total weight was 780 g. The portability of PRPM was much superior to the conventional instrument. The PRPM can operate automatically to estimate individual progeny concentration. All component materials of the monitor were selected based on the data of specified performance, cost performance and availability bon the market. The concentration of individual radon progeny was estimated by the build-up decay. It was concluded that PRPM is much suitable for outdoor study and personal dose estimation, as well as indoor measurement. In the field survey, especially in mines and caverns, PRPM is found as a valuable and convenient instrument. (M.N.)

  10. New strategy for evaluating grain cooking quality of progenies in dry bean breeding programs

    Directory of Open Access Journals (Sweden)

    Bruna Line Carvalho

    2017-04-01

    Full Text Available The methodology available for evaluating the cooking quality of dry beans is impractical for assessing a large number of progenies. The aims of this study were to propose a new strategy for evaluating cooking quality of grains and to estimate genetic and phenotypic parameters using a selection index. A total of 256 progenies of the 13thcycle of a recurrent selection program were evaluated at three locations for yield, grain type, and cooked grains. Samples of grains from each progeny were placing in a cooker and the percentage of cooked grains was assessed. The new strategy for evaluating cooking quality was efficient because it allowed a nine-fold increase in the number of progenies evaluated per unit time in comparison to available methods. The absence of association between grain yield and percentage of cooked grains or grain type indicated that it is possible to select high yielding lines with excellent grain aspect and good cooking properties using a selection index.

  11. FDG-PET improves the staging and selection of patients with recurrent colorectal cancer

    International Nuclear Information System (INIS)

    Lonneux, Max; Reffad, Abdel-Malek; Pauwels, Stanislas; Detry, Roger; Kartheuser, Alex; Gigot, Jean-Francois

    2002-01-01

    Whole-body fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET) has proved effective in the diagnosis and staging of recurrent colorectal cancer. In this study, we analysed how PET affects the management of patients with recurrent colorectal cancer by permitting more accurate selection of candidates for curative resection. The data of 79 patients with known or suspected recurrent colorectal cancer were analysed. Conventional imaging modalities (CIM) and PET results were compared with regard to their accuracy in determining the extent and the resectability of tumour recurrence. Recurrence was demonstrated in 68 of the 79 patients. The data indicate that PET was superior to CIM for detection of recurrence at all sites except the liver. Based on the CIM+PET staging, surgery with curative intent was proposed in 39 patients and was indeed achieved in 31 of them (80%). PET was more accurate than CIM alone in predicting the resectability or non-resectability of the recurrence (82% vs 68%, P=0.02). It is concluded that whole-body FDG-PET is highly sensitive for both the diagnosis and the staging of patients with recurrent colorectal cancer. Its use in conjunction with conventional imaging procedures results in a more accurate selection of patients for surgical treatment with curative intent. (orig.)

  12. Enhancing Breast Cancer Recurrence Algorithms Through Selective Use of Medical Record Data.

    Science.gov (United States)

    Kroenke, Candyce H; Chubak, Jessica; Johnson, Lisa; Castillo, Adrienne; Weltzien, Erin; Caan, Bette J

    2016-03-01

    The utility of data-based algorithms in research has been questioned because of errors in identification of cancer recurrences. We adapted previously published breast cancer recurrence algorithms, selectively using medical record (MR) data to improve classification. We evaluated second breast cancer event (SBCE) and recurrence-specific algorithms previously published by Chubak and colleagues in 1535 women from the Life After Cancer Epidemiology (LACE) and 225 women from the Women's Health Initiative cohorts and compared classification statistics to published values. We also sought to improve classification with minimal MR examination. We selected pairs of algorithms-one with high sensitivity/high positive predictive value (PPV) and another with high specificity/high PPV-using MR information to resolve discrepancies between algorithms, properly classifying events based on review; we called this "triangulation." Finally, in LACE, we compared associations between breast cancer survival risk factors and recurrence using MR data, single Chubak algorithms, and triangulation. The SBCE algorithms performed well in identifying SBCE and recurrences. Recurrence-specific algorithms performed more poorly than published except for the high-specificity/high-PPV algorithm, which performed well. The triangulation method (sensitivity = 81.3%, specificity = 99.7%, PPV = 98.1%, NPV = 96.5%) improved recurrence classification over two single algorithms (sensitivity = 57.1%, specificity = 95.5%, PPV = 71.3%, NPV = 91.9%; and sensitivity = 74.6%, specificity = 97.3%, PPV = 84.7%, NPV = 95.1%), with 10.6% MR review. Triangulation performed well in survival risk factor analyses vs analyses using MR-identified recurrences. Use of multiple recurrence algorithms in administrative data, in combination with selective examination of MR data, may improve recurrence data quality and reduce research costs. © The Author 2015. Published by Oxford University Press. All rights reserved. For

  13. Accuracy of Genomic Selection in a Rice Synthetic Population Developed for Recurrent Selection Breeding.

    Directory of Open Access Journals (Sweden)

    Cécile Grenier

    Full Text Available Genomic selection (GS is a promising strategy for enhancing genetic gain. We investigated the accuracy of genomic estimated breeding values (GEBV in four inter-related synthetic populations that underwent several cycles of recurrent selection in an upland rice-breeding program. A total of 343 S2:4 lines extracted from those populations were phenotyped for flowering time, plant height, grain yield and panicle weight, and genotyped with an average density of one marker per 44.8 kb. The relative effect of the linkage disequilibrium (LD and minor allele frequency (MAF thresholds for selecting markers, the relative size of the training population (TP and of the validation population (VP, the selected trait and the genomic prediction models (frequentist and Bayesian on the accuracy of GEBVs was investigated in 540 cross validation experiments with 100 replicates. The effect of kinship between the training and validation populations was tested in an additional set of 840 cross validation experiments with a single genomic prediction model. LD was high (average r2 = 0.59 at 25 kb and decreased slowly, distribution of allele frequencies at individual loci was markedly skewed toward unbalanced frequencies (MAF average value 15.2% and median 9.6%, and differentiation between the four synthetic populations was low (FST ≤0.06. The accuracy of GEBV across all cross validation experiments ranged from 0.12 to 0.54 with an average of 0.30. Significant differences in accuracy were observed among the different levels of each factor investigated. Phenotypic traits had the biggest effect, and the size of the incidence matrix had the smallest. Significant first degree interaction was observed for GEBV accuracy between traits and all the other factors studied, and between prediction models and LD, MAF and composition of the TP. The potential of GS to accelerate genetic gain and breeding options to increase the accuracy of predictions are discussed.

  14. Accuracy of Genomic Selection in a Rice Synthetic Population Developed for Recurrent Selection Breeding.

    Science.gov (United States)

    Grenier, Cécile; Cao, Tuong-Vi; Ospina, Yolima; Quintero, Constanza; Châtel, Marc Henri; Tohme, Joe; Courtois, Brigitte; Ahmadi, Nourollah

    2015-01-01

    Genomic selection (GS) is a promising strategy for enhancing genetic gain. We investigated the accuracy of genomic estimated breeding values (GEBV) in four inter-related synthetic populations that underwent several cycles of recurrent selection in an upland rice-breeding program. A total of 343 S2:4 lines extracted from those populations were phenotyped for flowering time, plant height, grain yield and panicle weight, and genotyped with an average density of one marker per 44.8 kb. The relative effect of the linkage disequilibrium (LD) and minor allele frequency (MAF) thresholds for selecting markers, the relative size of the training population (TP) and of the validation population (VP), the selected trait and the genomic prediction models (frequentist and Bayesian) on the accuracy of GEBVs was investigated in 540 cross validation experiments with 100 replicates. The effect of kinship between the training and validation populations was tested in an additional set of 840 cross validation experiments with a single genomic prediction model. LD was high (average r2 = 0.59 at 25 kb) and decreased slowly, distribution of allele frequencies at individual loci was markedly skewed toward unbalanced frequencies (MAF average value 15.2% and median 9.6%), and differentiation between the four synthetic populations was low (FST ≤0.06). The accuracy of GEBV across all cross validation experiments ranged from 0.12 to 0.54 with an average of 0.30. Significant differences in accuracy were observed among the different levels of each factor investigated. Phenotypic traits had the biggest effect, and the size of the incidence matrix had the smallest. Significant first degree interaction was observed for GEBV accuracy between traits and all the other factors studied, and between prediction models and LD, MAF and composition of the TP. The potential of GS to accelerate genetic gain and breeding options to increase the accuracy of predictions are discussed.

  15. Resection of recurrent branchial cleft deformity using selective neck dissection technique.

    Science.gov (United States)

    Cai, Qian; Pan, Yong; Xu, Yaodong; Liang, Faya; Huang, Xiaoming; Jiang, Xiaoyu; Han, Ping

    2014-07-01

    This study explores application of selective neck dissection technique in recurrent second, third, and fourth branchial cleft deformities. A total of 19 cases of recurrent second, third, and fourth branchial cleft deformities were treated using the selective neck dissection technique, during which the sternocleidomastoid muscle, cervical anterior muscle, and carotid sheath were contoured. The lesion above the prevertebral fascia was then resected en bloc. Finally, the opening of the internal fistula was ligated and sutured using the purse-string approach. Patients in this study had no injures to their internal carotid artery, jugular vein, vagus nerve, accessory nerve, hypoglossal nerve, or recurrent laryngeal nerve. There were also no complications such as poor wound healing. The patients were monitored for 7-73 months and showed no recurrences. Using selective neck dissection to treat second, third, and fourth branchial cleft deformities resulted in en bloc lesion resections and reduced the chance of recurrence. Contouring the sternocleidomastoid muscle, strap muscle, and carotid sheath is key to the surgical procedure, as it leads to en bloc lesion resection while retaining the recurrent laryngeal nerve and carotid sheath. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  16. Recurrent selection increases the seed germination of little bluestem (Schizachyrium scoparium)

    Science.gov (United States)

    Rainfall is often inadequate for satisfactory seed germination and emergence under field conditions. This research was designed to improve the seed germination of six experimental lines of little bluestem [Schizachyrium scoparium (Michx.) Nash]. Two cycle of recurrent selection were used to develo...

  17. Choosing tree genotypes for phytoremediation of landfill leachate using phyto-recurrent selection

    Science.gov (United States)

    Jill A. Zalesny; Ronald S., Jr. Zalesny; Adam H. Wiese; Richard B. Hall

    2007-01-01

    Information about the response of poplar (Populus spp.) genotypes to landfill leachate irrigation is needed, along with efficient methods for choosing genotypes based on leachate composition. Poplar clones were irrigated during three cycles of phyto-recurrent selection to test whether genotypes responded differently to leachate and water, and to test...

  18. Selective Attention and Fear of Cancer Recurrence in Breast Cancer Survivors

    NARCIS (Netherlands)

    Custers, J. A. E.; Becker, E. S.; Gielissen, M. F. M.; van Laarhoven, H. W. M.; Rinck, M.; Prins, J. B.

    2015-01-01

    Anxious people show an attentional bias towards threatening information. It was investigated whether an attentional bias exists for cancer-related stimuli in breast cancer survivors and if different levels of fear of cancer recurrence would lead to different patterns of selective attention. Breast

  19. Soft sweeps III: the signature of positive selection from recurrent mutation.

    Directory of Open Access Journals (Sweden)

    Pleuni S Pennings

    2006-12-01

    Full Text Available Polymorphism data can be used to identify loci at which a beneficial allele has recently gone to fixation, given that an accurate description of the signature of selection is available. In the classical model that is used, a favored allele derives from a single mutational origin. This ignores the fact that beneficial alleles can enter a population recurrently by mutation during the selective phase. In this study, we present a combination of analytical and simulation results to demonstrate the effect of adaptation from recurrent mutation on summary statistics for polymorphism data from a linked neutral locus. We also analyze the power of standard neutrality tests based on the frequency spectrum or on linkage disequilibrium (LD under this scenario. For recurrent beneficial mutation at biologically realistic rates, we find substantial deviations from the classical pattern of a selective sweep from a single new mutation. Deviations from neutrality in the level of polymorphism and in the frequency spectrum are much less pronounced than in the classical sweep pattern. In contrast, for levels of LD, the signature is even stronger if recurrent beneficial mutation plays a role. We suggest a variant of existing LD tests that increases their power to detect this signature.

  20. Immunoliposome-mediated delivery of neomycin phosphotransferase for the lineage-specific selection of differentiated/committed stem cell progenies: potential advantages over transfection with marker genes, fluorescence-activated and magnetic affinity cell-sorting.

    Science.gov (United States)

    Heng, Boon Chin; Cao, Tong

    2005-01-01

    A major challenge in the therapeutic application of stem cells in regenerative medicine is the lineage-specific selection of their committed/differentiated progenies for transplantation. This is necessary to avoid engraftment of undesired lineages at the transplantation site, i.e. fibroblastic scar tissue, as well as to enhance the efficacy of transplantation therapy. Commonly used techniques for lineage-specific selection of committed/differentiated stem cell progenies include marker gene transfection, fluorescence-activated (FACS) and magnetic-affinity (MACS) cell-sorting. Nevertheless, these have their disadvantages for therapeutic applications. Marker gene transfection invariably leads to permanent genetic modification of stem cells, which in turn limits their use in human clinical therapy due to overwhelming ethical and safety concerns. FACS requires expensive instrumentation and highly-skilled personnel, and is unsuited for handling bulk quantities of cells that would almost certainly be required for transplantation therapy. MACS is a cheaper alternative, but the level of purity attained is also reduced. A possible novel approach that has yet to be investigated is immunoliposome-mediated delivery of neomycin phosphotranferase (NPT) for lineage-specific selection of stem cell progenies. This would avoid permanent genetic modification to the cell, unlike recombinant NPT expression linked to activation of specific promoter sequences. Moreover, it could potentially provide a much more practical and cost-effective alternative for handling bulk quantities of cells that would be required for transplantation therapy, as compared to FACS or MACS. As such, this alternative approach needs to be rigorously investigated, in view of its potentially useful applications in stem cell therapeutics.

  1. Spatially dynamic recurrent information flow across long-range dorsal motor network encodes selective motor goals.

    Science.gov (United States)

    Yoo, Peter E; Hagan, Maureen A; John, Sam E; Opie, Nicholas L; Ordidge, Roger J; O'Brien, Terence J; Oxley, Thomas J; Moffat, Bradford A; Wong, Yan T

    2018-03-08

    Performing voluntary movements involves many regions of the brain, but it is unknown how they work together to plan and execute specific movements. We recorded high-resolution ultra-high-field blood-oxygen-level-dependent signal during a cued ankle-dorsiflexion task. The spatiotemporal dynamics and the patterns of task-relevant information flow across the dorsal motor network were investigated. We show that task-relevant information appears and decays earlier in the higher order areas of the dorsal motor network then in the primary motor cortex. Furthermore, the results show that task-relevant information is encoded in general initially, and then selective goals are subsequently encoded in specifics subregions across the network. Importantly, the patterns of recurrent information flow across the network vary across different subregions depending on the goal. Recurrent information flow was observed across all higher order areas of the dorsal motor network in the subregions encoding for the current goal. In contrast, only the top-down information flow from the supplementary motor cortex to the frontoparietal regions, with weakened recurrent information flow between the frontoparietal regions and bottom-up information flow from the frontoparietal regions to the supplementary cortex were observed in the subregions encoding for the opposing goal. We conclude that selective motor goal encoding and execution rely on goal-dependent differences in subregional recurrent information flow patterns across the long-range dorsal motor network areas that exhibit graded functional specialization. © 2018 Wiley Periodicals, Inc.

  2. Genetic Variation Among Open-Pollinated Progeny of Eastern Cottonwood

    Science.gov (United States)

    R. E. Farmer

    1970-01-01

    Improvement programs in eastern cottonwood (Populus deltoides Bartr.) are most frequently designed to produce genetically superior clones for direct commercial use. This paper describes a progeny test to assess genetic variability on which selection might be based.

  3. A general population genetic framework for antagonistic selection that accounts for demography and recurrent mutation.

    Science.gov (United States)

    Connallon, Tim; Clark, Andrew G

    2012-04-01

    Antagonistic selection--where alleles at a locus have opposing effects on male and female fitness ("sexual antagonism") or between components of fitness ("antagonistic pleiotropy")--might play an important role in maintaining population genetic variation and in driving phylogenetic and genomic patterns of sexual dimorphism and life-history evolution. While prior theory has thoroughly characterized the conditions necessary for antagonistic balancing selection to operate, we currently know little about the evolutionary interactions between antagonistic selection, recurrent mutation, and genetic drift, which should collectively shape empirical patterns of genetic variation. To fill this void, we developed and analyzed a series of population genetic models that simultaneously incorporate these processes. Our models identify two general properties of antagonistically selected loci. First, antagonistic selection inflates heterozygosity and fitness variance across a broad parameter range--a result that applies to alleles maintained by balancing selection and by recurrent mutation. Second, effective population size and genetic drift profoundly affect the statistical frequency distributions of antagonistically selected alleles. The "efficacy" of antagonistic selection (i.e., its tendency to dominate over genetic drift) is extremely weak relative to classical models, such as directional selection and overdominance. Alleles meeting traditional criteria for strong selection (N(e)s > 1, where N(e) is the effective population size, and s is a selection coefficient for a given sex or fitness component) may nevertheless evolve as if neutral. The effects of mutation and demography may generate population differences in overall levels of antagonistic fitness variation, as well as molecular population genetic signatures of balancing selection.

  4. Thoron and radon progeny concentration measurements using direct progeny sensors in HLNRAs of Kerala

    International Nuclear Information System (INIS)

    Mishra, R.; Prajith, R.; Gole, A.C.; Kanse, S.D.; Chougaonkar, M.P.; Sapra, B.K.; Mayya, Y.S.; Jayalekshmi, P.; Nair, Raghu Ram K.

    2010-01-01

    Passive Progeny Dosimeters (PPDs) were deployed in 500 houses in 3 villages namely Allapad, Chavara and Neendakara villages of Karunagapally Taluk of Kollam district of Kerala. Each PPD unit is a combination of a DTPS and a DRPS placed side-by-side for time integrated thoron and radon progeny concentration estimation respectively. The PPDs were suspended vertically in the rooms, such that the nearest distance from any wall or surface was at least 30 cm. These are, as of now, being exposed for a period of 3 months, after which they will be retrieved and analysed by chemical etching and track counting. Simultaneously, external gamma radiation measurements have also been made using a survey meter; these showed a variation from 13 to 118 μR/h in indoors and 21 to 213 μR/h in the outdoor environments. Spot measurements of thoron progeny concentrations were also made in 7 selected houses using the conventional grab filter-paper sampling technique at a flow-rate of 21 min -1 for 30 minutes, followed by alpha counting. The average thoron progeny concentration was found to be 2.0 ± 0.7 Bq m -3 . In the outdoor environment, filter-paper sampling was carried out for 2 hours at 21 min -1 and the thoron progeny concentration was measured as 2.96 Bq m -3 . To corroborate these measurements, a flow mode integrated sampler which uses the DTPS and DRPS elements was used

  5. Recurrent twin-twin transfusion syndrome after selective fetoscopic laser photocoagulation: a systematic review of the literature.

    LENUS (Irish Health Repository)

    Walsh, C A

    2012-11-01

    Selective fetoscopic laser photocoagulation (SFLP) is now the treatment of choice for twin-twin transfusion syndrome (TTTS). The incidence of recurrent TTTS following SFLP has been inconsistently reported across different studies. We performed a systematic review of TTTS recurrence following SFLP.

  6. Recurrent selection on the Winters sex-ratio genes in Drosophila simulans.

    Science.gov (United States)

    Kingan, Sarah B; Garrigan, Daniel; Hartl, Daniel L

    2010-01-01

    Selfish genes, such as meiotic drive elements, propagate themselves through a population without increasing the fitness of host organisms. X-linked (or Y-linked) meiotic drive elements reduce the transmission of the Y (X) chromosome and skew progeny and population sex ratios, leading to intense conflict among genomic compartments. Drosophila simulans is unusual in having a least three distinct systems of X chromosome meiotic drive. Here, we characterize naturally occurring genetic variation at the Winters sex-ratio driver (Distorter on the X or Dox), its progenitor gene (Mother of Dox or MDox), and its suppressor gene (Not Much Yang or Nmy), which have been previously mapped and characterized. We survey three North American populations as well as 13 globally distributed strains and present molecular polymorphism data at the three loci. We find that all three genes show signatures of selection in North America, judging from levels of polymorphism and skews in the site-frequency spectrum. These signatures likely result from the biased transmission of the driver and selection on the suppressor for the maintenance of equal sex ratios. Coalescent modeling indicates that the timing of selection is more recent than the age of the alleles, suggesting that the driver and suppressor are coevolving under an evolutionary "arms race." None of the Winters sex-ratio genes are fixed in D. simulans, and at all loci we find ancestral alleles, which lack the gene insertions and exhibit high levels of nucleotide polymorphism compared to the derived alleles. In addition, we find several "null" alleles that have mutations on the derived Dox background, which result in loss of drive function. We discuss the possible causes of the maintenance of presence-absence polymorphism in the Winters sex-ratio genes.

  7. Optimal Feature Space Selection in Detecting Epileptic Seizure based on Recurrent Quantification Analysis and Genetic Algorithm

    Directory of Open Access Journals (Sweden)

    Saleh LAshkari

    2016-06-01

    Full Text Available Selecting optimal features based on nature of the phenomenon and high discriminant ability is very important in the data classification problems. Since it doesn't require any assumption about stationary condition and size of the signal and the noise in Recurrent Quantification Analysis (RQA, it may be useful for epileptic seizure Detection. In this study, RQA was used to discriminate ictal EEG from the normal EEG where optimal features selected by combination of algorithm genetic and Bayesian Classifier. Recurrence plots of hundred samples in each two categories were obtained with five distance norms in this study: Euclidean, Maximum, Minimum, Normalized and Fixed Norm. In order to choose optimal threshold for each norm, ten threshold of ε was generated and then the best feature space was selected by genetic algorithm in combination with a bayesian classifier. The results shown that proposed method is capable of discriminating the ictal EEG from the normal EEG where for Minimum norm and 0.1˂ε˂1, accuracy was 100%. In addition, the sensitivity of proposed framework to the ε and the distance norm parameters was low. The optimal feature presented in this study is Trans which it was selected in most feature spaces with high accuracy.

  8. Distribution of orientation selectivity in recurrent networks of spiking neurons with different random topologies.

    Science.gov (United States)

    Sadeh, Sadra; Rotter, Stefan

    2014-01-01

    Neurons in the primary visual cortex are more or less selective for the orientation of a light bar used for stimulation. A broad distribution of individual grades of orientation selectivity has in fact been reported in all species. A possible reason for emergence of broad distributions is the recurrent network within which the stimulus is being processed. Here we compute the distribution of orientation selectivity in randomly connected model networks that are equipped with different spatial patterns of connectivity. We show that, for a wide variety of connectivity patterns, a linear theory based on firing rates accurately approximates the outcome of direct numerical simulations of networks of spiking neurons. Distance dependent connectivity in networks with a more biologically realistic structure does not compromise our linear analysis, as long as the linearized dynamics, and hence the uniform asynchronous irregular activity state, remain stable. We conclude that linear mechanisms of stimulus processing are indeed responsible for the emergence of orientation selectivity and its distribution in recurrent networks with functionally heterogeneous synaptic connectivity.

  9. Seleção recorrente fenotípica para florescimento precoce de feijoeiro 'Carioca' Phenotypic recurrent selection for early flowering of 'Carioca' common bean

    Directory of Open Access Journals (Sweden)

    Flávia Barbosa Silva

    2007-10-01

    :2 progenies of each cycle were used for evaluation of the genetic progress. The number of days to flowering, severity of angular leaf spot (Phaeoisariopsis griseola, number of days to maturation, yield and grain type were evaluated. A selection gain of 2.2% per year was observed, which indicates that phenotypic recurrent selection reduced the number of days to flowering. The selection for the number of days to flowering had no correlated response with other evaluated traits, indicating that progeny selection for early flowering can be associated with the phenotypic expression of other traits, according to the breeder's interest.

  10. Family versus individual plant selection for stem borer ( Eldana ...

    African Journals Online (AJOL)

    Parents selected from breeding programmes where E. saccharina is endemic consistently produced less damaged progenies than those from low E. saccharina infestation, indicating the occurrence of natural and recurrent selection. The results suggested presence of additive and non-additive genetic effects as well as ...

  11. Recurrent pain is associated with decreased selective attention in a population-based sample.

    Science.gov (United States)

    Gijsen, C P; Dijkstra, J B; van Boxtel, M P J

    2011-01-01

    Studies which have examined the impact of pain on cognitive functioning in the general population are scarce. In the present study we assessed the predictive value of recurrent pain on cognitive functioning in a population-based study (N=1400). Furthermore, we investigated the effect of pain on cognitive functioning in individuals with specific pain complaints (i.e. back pain, gastric pain, muscle pain and headache). Cognitive functioning was assessed using the Stroop Color-Word Interference test (Stroop interference), the Letter-Digit-Substitution test (LDST) and the Visual Verbal learning Task (VVLT). Pain was measured with the COOP/WONCA pain scale (Dartmouth Primary Care Cooperative Information Project/World Organization of National Colleges, Academies, and Academic Associations of General Practice /Family Physicians). We controlled for the effects of age, sex, level of education and depressive symptoms. It was demonstrated that pain had a negative impact on the performance on the Stroop interference but not on the VVLT and the LDST. This indicates that subjects who reported extreme pain had more problems with selective attention and were more easily distracted. Effects were in general larger in the specific pain groups when compared to the associations found in the total group. Implications of these findings are discussed. The experience of recurrent pain has a negative influence on selective attention in a healthy population. Copyright © 2010 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.

  12. Evaluation of selected recurrence measures in discriminating pre-ictal and inter-ictal periods from epileptic EEG data

    Energy Technology Data Exchange (ETDEWEB)

    Ngamga, Eulalie Joelle [Potsdam Institute for Climate Impact Research, Telegraphenberg A 31, 14473 Potsdam (Germany); Bialonski, Stephan [Max-Planck-Institute for the Physics of Complex Systems, Nöthnitzer Straße 38, 01187 Dresden (Germany); Marwan, Norbert, E-mail: marwan@pik-potsdam.de [Potsdam Institute for Climate Impact Research, Telegraphenberg A 31, 14473 Potsdam (Germany); Kurths, Jürgen [Potsdam Institute for Climate Impact Research, Telegraphenberg A 31, 14473 Potsdam (Germany); Department of Physics, Humboldt University Berlin, 12489 Berlin (Germany); Institute for Complex Systems and Mathematical Biology, University of Aberdeen, Aberdeen AB24 3UE (United Kingdom); Geier, Christian [Department of Epileptology, University of Bonn, Sigmund-Freud-Straße 25, 53105 Bonn (Germany); Helmholtz Institute for Radiation and Nuclear Physics, University of Bonn, Nussallee 14–16, 53115 Bonn (Germany); Lehnertz, Klaus [Department of Epileptology, University of Bonn, Sigmund-Freud-Straße 25, 53105 Bonn (Germany); Helmholtz Institute for Radiation and Nuclear Physics, University of Bonn, Nussallee 14–16, 53115 Bonn (Germany); Interdisciplinary Center for Complex Systems, University of Bonn, Brühler Straße 7, 53175 Bonn (Germany)

    2016-04-01

    We investigate the suitability of selected measures of complexity based on recurrence quantification analysis and recurrence networks for an identification of pre-seizure states in multi-day, multi-channel, invasive electroencephalographic recordings from five epilepsy patients. We employ several statistical techniques to avoid spurious findings due to various influencing factors and due to multiple comparisons and observe precursory structures in three patients. Our findings indicate a high congruence among measures in identifying seizure precursors and emphasize the current notion of seizure generation in large-scale epileptic networks. A final judgment of the suitability for field studies, however, requires evaluation on a larger database. - Highlights: • Recurrence-based analysis of brain dynamics in human epilepsy. • Comparison of recurrence quantification and recurrence network measures. • Statistically significant precursory structures in three out of five patients. • High congruence among measures in characterizing brain dynamics.

  13. Evaluation of selected recurrence measures in discriminating pre-ictal and inter-ictal periods from epileptic EEG data

    International Nuclear Information System (INIS)

    Ngamga, Eulalie Joelle; Bialonski, Stephan; Marwan, Norbert; Kurths, Jürgen; Geier, Christian; Lehnertz, Klaus

    2016-01-01

    We investigate the suitability of selected measures of complexity based on recurrence quantification analysis and recurrence networks for an identification of pre-seizure states in multi-day, multi-channel, invasive electroencephalographic recordings from five epilepsy patients. We employ several statistical techniques to avoid spurious findings due to various influencing factors and due to multiple comparisons and observe precursory structures in three patients. Our findings indicate a high congruence among measures in identifying seizure precursors and emphasize the current notion of seizure generation in large-scale epileptic networks. A final judgment of the suitability for field studies, however, requires evaluation on a larger database. - Highlights: • Recurrence-based analysis of brain dynamics in human epilepsy. • Comparison of recurrence quantification and recurrence network measures. • Statistically significant precursory structures in three out of five patients. • High congruence among measures in characterizing brain dynamics.

  14. Seleção de progênies de meio-irmãos de cenoura baseada em características de sementes Selection of carrot progenies based on seed characteristics

    Directory of Open Access Journals (Sweden)

    Jairo V. Vieira

    2005-03-01

    Full Text Available A menor germinação e emergência de plântulas em campo de cenoura obtida nas sementes de cultivares nacionais em relação às importadas, aumenta o custo de produção além de impossibilitar a otimização do estande final através do emprego de semeadeiras de precisão. Setenta e quatro progênies de meio-irmãos oriundas de uma população de cenoura tipo Brasília foram avaliadas quanto a germinação, vigor e peso de sementes com o objetivo de verificar a variabilidade e as relações genéticas entre os referidos caracteres. Evidenciou-se a existência de diferenças significativas entre as progênies de meio-irmãos em relação a todos os caracteres avaliados. Os altos valores de herdabilidade e variabilidade genética entre progênies para os caracteres avaliados sugerem que métodos de melhoramento simples combinados com métodos de seleção tendo por base a teoria de índice podem ser aplicados visando a melhoria da qualidade fisiológica das sementes de cenoura.Low seed germination and stand establishment of carrot seeds from Brazilian cultivars generally increase the production cost and impairs the use of precision seeders. Germination, vigor and seed weight of 74 progenies from a population of carrot cv. Brasilia were evaluated to verify the variability and the genetic relations among these three characteristics. Significant differences were observed among the progenies in relation to all characteristics. High values of heritability and genetic variability among progenies suggests that simple breeding methods combined with index selection methods may be applied during breeding programs in order to increase the physiological seed quality of carrot.

  15. Low-dose aspirin, non-steroidal anti-inflammatory drugs, selective COX-2 inhibitors and breast cancer recurrence

    DEFF Research Database (Denmark)

    Cronin-Fenton, Deirdre P; Heide-Jørgensen, Uffe; Ahern, Thomas P

    2016-01-01

    BACKGROUND: Aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), and selective COX-2 inhibitors may improve outcomes in breast cancer patients. We investigated the association of aspirin, NSAIDs, and use of selective COX-2 inhibitors with breast cancer recurrence. METHODS: We identified incident...... stage I-III Danish breast cancer patients in the Danish Breast Cancer Cooperative Group registry, who were diagnosed during 1996-2008. Prescriptions for aspirin (>99% low-dose aspirin), NSAIDs, and selective COX-2 inhibitors were ascertained from the National Prescription Registry. Follow-up began....... RESULTS: We identified 34,188 breast cancer patients with 233,130 person-years of follow-up. Median follow-up was 7.1 years; 5,325 patients developed recurrent disease. Use of aspirin, NSAIDs, or selective COX-2 inhibitors was not associated with the rate of recurrence (HRadjusted aspirin = 1.0, 95% CI...

  16. A radon progeny deposition model

    International Nuclear Information System (INIS)

    Rielage, Keith; Elliott, Steven R.; Hime, Andrew; Guiseppe, Vincent E.; Westerdale, S.

    2010-01-01

    The next generation low-background detectors operating underground aim for unprecedented low levels of radioactive backgrounds. Although the radioactive decays of airborne radon (particularly 222 Rn) and its subsequent progeny present in an experiment are potential backgrounds, also problematic is the deposition of radon progeny on detector materials. Exposure to radon at any stage of assembly of an experiment can result in surface contamination by progeny supported by the long half life (22 y) of 210 Pb on sensitive locations of a detector. An understanding of the potential surface contamination from deposition will enable requirements of radon-reduced air and clean room environments for the assembly of low background experiments. It is known that there are a number of environmental factors that govern the deposition of progeny onto surfaces. However, existing models have not explored the impact of some environmental factors important for low background experiments. A test stand has been constructed to deposit radon progeny on various surfaces under a controlled environment in order to develop a deposition model. Results from this test stand and the resulting deposition model are presented.

  17. A Radon Progeny Deposition Model

    International Nuclear Information System (INIS)

    Guiseppe, V. E.; Elliott, S. R.; Hime, A.; Rielage, K.; Westerdale, S.

    2011-01-01

    The next generation low-background detectors operating underground aim for unprecedented low levels of radioactive backgrounds. Although the radioactive decays of airborne radon (particularly 222 Rn) and its subsequent progeny present in an experiment are potential backgrounds, also problematic is the deposition of radon progeny on detector materials. Exposure to radon at any stage of assembly of an experiment can result in surface contamination by progeny supported by the long half life (22 y) of 210 Pb on sensitive locations of a detector. An understanding of the potential surface contamination from deposition will enable requirements of radon-reduced air and clean room environments for the assembly of low background experiments. It is known that there are a number of environmental factors that govern the deposition of progeny onto surfaces. However, existing models have not explored the impact of some environmental factors important for low background experiments. A test stand has been constructed to deposit radon progeny on various surfaces under a controlled environment in order to develop a deposition model. Results from this test stand and the resulting deposition model are presented.

  18. Selective recurrent laryngeal nerve stimulation using a penetrating electrode array in the feline model.

    Science.gov (United States)

    Haidar, Yarah M; Sahyouni, Ronald; Moshtaghi, Omid; Wang, Beverly Y; Djalilian, Hamid R; Middlebrooks, John C; Verma, Sunil P; Lin, Harrison W

    2017-10-31

    Laryngeal muscles (LMs) are controlled by the recurrent laryngeal nerve (RLN), injury of which can result in vocal fold (VF) paralysis (VFP). We aimed to introduce a bioelectric approach to selective stimulation of LMs and graded muscle contraction responses. Acute experiments in cats. The study included six anesthetized cats. In four cats, a multichannel penetrating microelectrode array (MEA) was placed into an uninjured RLN. For RLN injury experiments, one cat received a standardized hemostat-crush injury, and one cat received a transection-reapproximation injury 4 months prior to testing. In each experiment, three LMs (thyroarytenoid, posterior cricoarytenoid, and cricothyroid muscles) were monitored with an electromyographic (EMG) nerve integrity monitoring system. Electrical current pulses were delivered to each stimulating channel individually. Elicited EMG voltage outputs were recorded for each muscle. Direct videolaryngoscopy was performed for visualization of VF movement. Stimulation through individual channels led to selective activation of restricted nerve populations, resulting in selective contraction of individual LMs. Increasing current levels resulted in rising EMG voltage responses. Typically, activation of individual muscles was successfully achieved via single placement of the MEA by selection of appropriate stimulation channels. VF abduction was predominantly observed on videolaryngoscopy. Nerve histology confirmed injury in cases of RLN crush and transection experiments. We demonstrated the ability of a penetrating MEA to selectively stimulate restricted fiber populations within the feline RLN and selectively elicit contractions of discrete LMs in both acute and injury-model experiments, suggesting a potential role for intraneural MEA implantation in VFP management. NA Laryngoscope, 2017. © 2017 The American Laryngological, Rhinological and Otological Society, Inc.

  19. Improvement of resistance to rust through recurrent selection in pearl millet

    Energy Technology Data Exchange (ETDEWEB)

    Tapsoba, H. [Univ. of Georgia, Athens, GA (United States); Wilson, J.P.; Hanna, W.W. [Univ. of Georgia Coastal Plain Experimental Station, Tifton, GA (United States)

    1997-04-01

    Two pearl millet [Pennisetum glaucum (L.) R.Br. = P. typhoides (Burm.) Staff & Hubb., P. americanum (L.) K. Schum.] bulk populations, Tift No. 2 and Tift No. 5, served as base populations for four cycles of recurrent selection against susceptibility to Puccinia substriata Ell. & Barth, var. indica Ramachar & Cumm. A bulk inoculum of the pathogen was used. The objectives were to evaluate the progress achieved regarding overall resistance to the pathogen in the field and resistance to different races of the pathogen, and also to evaluate changes in unselected traits. During selection, the frequency of rust resistant plants continuously increased from about 30% in each base population to more than 85% by the third cycle of selection in both populations. An average increase of about 21 and 18% per cycle was obtained in Tift No. 2 and Tift No. 5, respectively. A continuous increase of the frequency of plants resistant to some races of the pathogen was also obtained. In Tift No. 5, 80% of the plants were resistant to eight races by the third cycle of selection. The accumulation of resistance observed in the seedlings was manifested in the field, both in 1993 and 1994, by a reduction of the final rust severity from the base population to the fourth selection cycle of both populations. This improvement in resistance to the rust pathogen was accompanied by an increase in the frequency of plants resistant to Pyricularia grisea (Cooke) Sacc. only in Tift No. 2. Despite the improvement in the selected character, genetic variability for agronomic traits such as plant height, number of culms/plant, flowering date, and panicle length was successfully maintained within each population. 20 refs., 1 fig., 7 tabs.

  20. Recurrence predictive models for patients with hepatocellular carcinoma after radiofrequency ablation using support vector machines with feature selection methods.

    Science.gov (United States)

    Liang, Ja-Der; Ping, Xiao-Ou; Tseng, Yi-Ju; Huang, Guan-Tarn; Lai, Feipei; Yang, Pei-Ming

    2014-12-01

    Recurrence of hepatocellular carcinoma (HCC) is an important issue despite effective treatments with tumor eradication. Identification of patients who are at high risk for recurrence may provide more efficacious screening and detection of tumor recurrence. The aim of this study was to develop recurrence predictive models for HCC patients who received radiofrequency ablation (RFA) treatment. From January 2007 to December 2009, 83 newly diagnosed HCC patients receiving RFA as their first treatment were enrolled. Five feature selection methods including genetic algorithm (GA), simulated annealing (SA) algorithm, random forests (RF) and hybrid methods (GA+RF and SA+RF) were utilized for selecting an important subset of features from a total of 16 clinical features. These feature selection methods were combined with support vector machine (SVM) for developing predictive models with better performance. Five-fold cross-validation was used to train and test SVM models. The developed SVM-based predictive models with hybrid feature selection methods and 5-fold cross-validation had averages of the sensitivity, specificity, accuracy, positive predictive value, negative predictive value, and area under the ROC curve as 67%, 86%, 82%, 69%, 90%, and 0.69, respectively. The SVM derived predictive model can provide suggestive high-risk recurrent patients, who should be closely followed up after complete RFA treatment. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  1. Persistency of Prediction Accuracy and Genetic Gain in Synthetic Populations Under Recurrent Genomic Selection.

    Science.gov (United States)

    Müller, Dominik; Schopp, Pascal; Melchinger, Albrecht E

    2017-03-10

    Recurrent selection (RS) has been used in plant breeding to successively improve synthetic and other multiparental populations. Synthetics are generated from a limited number of parents [Formula: see text] but little is known about how [Formula: see text] affects genomic selection (GS) in RS, especially the persistency of prediction accuracy ([Formula: see text]) and genetic gain. Synthetics were simulated by intermating [Formula: see text]= 2-32 parent lines from an ancestral population with short- or long-range linkage disequilibrium ([Formula: see text]) and subjected to multiple cycles of GS. We determined [Formula: see text] and genetic gain across 30 cycles for different training set ( TS ) sizes, marker densities, and generations of recombination before model training. Contributions to [Formula: see text] and genetic gain from pedigree relationships, as well as from cosegregation and [Formula: see text] between QTL and markers, were analyzed via four scenarios differing in (i) the relatedness between TS and selection candidates and (ii) whether selection was based on markers or pedigree records. Persistency of [Formula: see text] was high for small [Formula: see text] where predominantly cosegregation contributed to [Formula: see text], but also for large [Formula: see text] where [Formula: see text] replaced cosegregation as the dominant information source. Together with increasing genetic variance, this compensation resulted in relatively constant long- and short-term genetic gain for increasing [Formula: see text] > 4, given long-range LD A in the ancestral population. Although our scenarios suggest that information from pedigree relationships contributed to [Formula: see text] for only very few generations in GS, we expect a longer contribution than in pedigree BLUP, because capturing Mendelian sampling by markers reduces selective pressure on pedigree relationships. Larger TS size ([Formula: see text]) and higher marker density improved persistency of

  2. Persistency of Prediction Accuracy and Genetic Gain in Synthetic Populations Under Recurrent Genomic Selection

    Directory of Open Access Journals (Sweden)

    Dominik Müller

    2017-03-01

    Full Text Available Recurrent selection (RS has been used in plant breeding to successively improve synthetic and other multiparental populations. Synthetics are generated from a limited number of parents ( Np , but little is known about how Np affects genomic selection (GS in RS, especially the persistency of prediction accuracy (rg , g ^ and genetic gain. Synthetics were simulated by intermating Np= 2–32 parent lines from an ancestral population with short- or long-range linkage disequilibrium (LDA and subjected to multiple cycles of GS. We determined rg , g ^ and genetic gain across 30 cycles for different training set (TS sizes, marker densities, and generations of recombination before model training. Contributions to rg , g ^ and genetic gain from pedigree relationships, as well as from cosegregation and LDA between QTL and markers, were analyzed via four scenarios differing in (i the relatedness between TS and selection candidates and (ii whether selection was based on markers or pedigree records. Persistency of rg , g ^ was high for small Np , where predominantly cosegregation contributed to rg , g ^ , but also for large Np , where LDA replaced cosegregation as the dominant information source. Together with increasing genetic variance, this compensation resulted in relatively constant long- and short-term genetic gain for increasing Np > 4, given long-range LDA in the ancestral population. Although our scenarios suggest that information from pedigree relationships contributed to rg , g ^ for only very few generations in GS, we expect a longer contribution than in pedigree BLUP, because capturing Mendelian sampling by markers reduces selective pressure on pedigree relationships. Larger TS size (NTS and higher marker density improved persistency of rg , g ^ and hence genetic gain, but additional recombinations could not increase genetic gain.

  3. Genetic parameters and estimated genetic gains in young rubber tree progenies

    Directory of Open Access Journals (Sweden)

    Cecília Khusala Verardi

    2013-04-01

    Full Text Available The objective of this work was to assess the genetic parameters and to estimate genetic gains in young rubber tree progenies. The experiments were carried out during three years, in a randomized block design, with six replicates and ten plants per plot, in three representative Hevea crop regions of the state of São Paulo, Brazil. Twenty-two progenies were evaluated, from three to five years old, for rubber yield and annual girth growth. Genetic gain was estimated with the multi-effect index (MEI. Selection by progenies means provided greater estimated genetic gain than selection based on individuals, since heritability values of progeny means were greater than the ones of individual heritability, for both evaluated variables, in all the assessment years. The selection of the three best progenies for rubber yield provided a selection gain of 1.28 g per plant. The genetic gains estimated with MEI using data from early assessments (from 3 to 5-year-old were generally high for annual girth growth and rubber yield. The high genetic gains for annual girth growth in the first year of assessment indicate that progenies can be selected at the beginning of the breeding program. Population effective size was consistent with the three progenies selected, showing that they were not related and that the population genetic variability is ensured. Early selection with the genetic gains estimated by MEI can be made on rubber tree progenies.

  4. Evaluation of genome-enabled selection for bacterial cold water disease resistance using progeny performance data in Rainbow Trout: Insights on genotyping methods and genomic prediction models

    Science.gov (United States)

    Bacterial cold water disease (BCWD) causes significant economic losses in salmonid aquaculture, and traditional family-based breeding programs aimed at improving BCWD resistance have been limited to exploiting only between-family variation. We used genomic selection (GS) models to predict genomic br...

  5. Optimizing the number of progenies and replications in plant breeding experiments

    Directory of Open Access Journals (Sweden)

    João Luís da Silva Filho

    2013-01-01

    Full Text Available A determination criterion was proposed for the number of replications, r, and of evaluated progenies, Nr, given P experimentalplots, with Nr=P/r, and n progenies to be selected; its application was discussed in the selection of progenies of bulk populations,derived from two homozygous parents. For a known heritability at the plot level, h20, there is a critical n below which the gain isgreater with selection evaluating P/(r+1 progenies in r+1 than P/r progenies in r replications. Different h20 scenarios were simulatedin the F2 and F∞ generations, assuming no dominance. It was demonstrated that at any h20 , if n > 18.5% of P, larger gains are obtainedby assuming Nr = P, showing that the augmented block design could be used in the early stages of breeding programs. The higher h20,the higher must be the selection intensity to justify the use of additional replications.

  6. Responses to recurrent index selection for reduced fusarium ear rot and lodging and for increased yield in maize

    Science.gov (United States)

    Fusarium ear rot caused by the pathogen Fusarium verticillioides (Sacc.) Nirenberg damages maize (Zea mays L.) grain production and is associated with contamination of grain by fumonisin, a mycotoxin harmful to both humans and animals. Recurrent selection may be an effective way to combine improveme...

  7. Recurrent Selection and Participatory Plant Breeding for Improvement of Two Organic Open-Pollinated Sweet Corn (Zea mays L. Populations

    Directory of Open Access Journals (Sweden)

    Adrienne C. Shelton

    2015-04-01

    Full Text Available Organic growers face unique challenges when raising sweet corn, and benefit from varieties that maintain high eating quality, germinate consistently, deter insect pests, and resist diseases. Genotype by environment rank changes can occur in the performance of cultivars grown on conventional and organic farms, yet few varieties have been bred specifically for organic systems. The objective of this experiment was to evaluate the changes made to open-pollinated sweet corn populations using recurrent selection and a participatory plant breeding (PPB methodology. From 2008 to 2011, four cycles of two open-pollinated (OP sweet corn populations were selected on a certified organic farm in Minnesota using a modified ear-to-row recurrent selection scheme. Selections were made in collaboration with an organic farmer, with selection criteria based on traits identified by the farmer. In 2012 and 2013, the population cycles were evaluated in a randomized complete block design in two certified organic locations in Wisconsin, with multiple replications in each environment. Significant linear trends were found among cycles of selection for quantitative and qualitative traits, suggesting the changes were due to recurrent selection and PPB methodology for these populations. However, further improvement is necessary to satisfy the requirements for a useful cultivar for organic growers.

  8. Delay selection by spike-timing-dependent plasticity in recurrent networks of spiking neurons receiving oscillatory inputs.

    Directory of Open Access Journals (Sweden)

    Robert R Kerr

    Full Text Available Learning rules, such as spike-timing-dependent plasticity (STDP, change the structure of networks of neurons based on the firing activity. A network level understanding of these mechanisms can help infer how the brain learns patterns and processes information. Previous studies have shown that STDP selectively potentiates feed-forward connections that have specific axonal delays, and that this underlies behavioral functions such as sound localization in the auditory brainstem of the barn owl. In this study, we investigate how STDP leads to the selective potentiation of recurrent connections with different axonal and dendritic delays during oscillatory activity. We develop analytical models of learning with additive STDP in recurrent networks driven by oscillatory inputs, and support the results using simulations with leaky integrate-and-fire neurons. Our results show selective potentiation of connections with specific axonal delays, which depended on the input frequency. In addition, we demonstrate how this can lead to a network becoming selective in the amplitude of its oscillatory response to this frequency. We extend this model of axonal delay selection within a single recurrent network in two ways. First, we show the selective potentiation of connections with a range of both axonal and dendritic delays. Second, we show axonal delay selection between multiple groups receiving out-of-phase, oscillatory inputs. We discuss the application of these models to the formation and activation of neuronal ensembles or cell assemblies in the cortex, and also to missing fundamental pitch perception in the auditory brainstem.

  9. Bronchial dosimeter for radon progeny

    Energy Technology Data Exchange (ETDEWEB)

    Cheung, T.K.; Yu, K.N.; Nikezic, D.; Haque, A.K.M.M. [City University of Hong Kong, Hong Kong (China); Vucic, D. [Faculty of Technology, University of Nis, Lescovac (Yugoslavia)

    2000-05-01

    Traditionally, assessments of the bronchial dose from radon progeny were carried out by measuring the unattached fraction (f{sub p}) of potential alpha energy concentration (PAEC), the total PAEC, activity median diameters (AMDs) and equilibrium factor, and then using dosimetric lung models. A breakthrough was proposed by Hopke et al. (1990) to use multiple metal wire screens to mimic the deposition properties of radon progeny in the nasal (N) and tracheobronchial (T-B) regions directly. In particular, they were successful in using four layers of 400-mesh wire screens with a face velocity of 12 cm s{sup -1} for the simulation of radon progeny deposition in the T-B region. Oberstedt and Vanmarcke (1995) carried out precise calibrations for the system, and named the system as the 'bronchial dosimeter'. Based on these, Yu and Guan (1998) proposed a portable bronchial dosimeter similar to a normal measurement system for radon progeny or PAEC and consisted of only a single sampler and employed only one 400-mesh wire screen and one filter. However, all these 'bronchial dosimeters' in fact only determined the fraction of potential alpha energy from radon progeny deposited in the T-B region, which required certain assumptions and calculations to further give the final bronchial dose. In the present work, a true 'bronchial dosimeter' was designed, which consisted of three 400-mesh wire screens and a filter. With a face velocity of 11 cm s{sup -1}, the deposition pattern on the wire screens was found to satisfactorily match the variation of the dose conversion factor (in the unit of mSv/WLM) with the size of radon progeny from 1 to 1000 nm. In this way, this bronchial dosimeter directly gave the bronchial dose from the alpha counts recorded on the wire-screens and the filter paper. With the development of this bronchial dosimeter, the present practice of 'dose estimation' from large-scale radon surveys can be replaced by large

  10. Selective genomic copy number imbalances and probability of recurrence in early-stage breast cancer.

    Directory of Open Access Journals (Sweden)

    Patricia A Thompson

    Full Text Available A number of studies of copy number imbalances (CNIs in breast tumors support associations between individual CNIs and patient outcomes. However, no pattern or signature of CNIs has emerged for clinical use. We determined copy number (CN gains and losses using high-density molecular inversion probe (MIP arrays for 971 stage I/II breast tumors and applied a boosting strategy to fit hazards models for CN and recurrence, treating chromosomal segments in a dose-specific fashion (-1 [loss], 0 [no change] and +1 [gain]. The concordance index (C-Index was used to compare prognostic accuracy between a training (n = 728 and test (n = 243 set and across models. Twelve novel prognostic CNIs were identified: losses at 1p12, 12q13.13, 13q12.3, 22q11, and Xp21, and gains at 2p11.1, 3q13.12, 10p11.21, 10q23.1, 11p15, 14q13.2-q13.3, and 17q21.33. In addition, seven CNIs previously implicated as prognostic markers were selected: losses at 8p22 and 16p11.2 and gains at 10p13, 11q13.5, 12p13, 20q13, and Xq28. For all breast cancers combined, the final full model including 19 CNIs, clinical covariates, and tumor marker-approximated subtypes (estrogen receptor [ER], progesterone receptor, ERBB2 amplification, and Ki67 significantly outperformed a model containing only clinical covariates and tumor subtypes (C-Index(full model, train[test]  =  0.72[0.71] ± 0.02 vs. C-Index(clinical + subtype model, train[test]  =  0.62[0.62] ± 0.02; p<10(-6. In addition, the full model containing 19 CNIs significantly improved prognostication separately for ER-, HER2+, luminal B, and triple negative tumors over clinical variables alone. In summary, we show that a set of 19 CNIs discriminates risk of recurrence among early-stage breast tumors, independent of ER status. Further, our data suggest the presence of specific CNIs that promote and, in some cases, limit tumor spread.

  11. Parentage assignment of progeny in mixed milt fertilization of ...

    African Journals Online (AJOL)

    Administrator

    2011-06-13

    Jun 13, 2011 ... individuals. Overall, 98.8% of progeny were assigned to their parents using Family Assignment. Program (FAP). Selection of hyper-variable microsatellites in Caspian brown trout to identify unique alleles was effective for unambiguous parentage determination and estimation of genetic diversity in this study.

  12. Integrating measurements of indoor thoron and its progeny concentrations

    International Nuclear Information System (INIS)

    Zhuo, W.H.; Iida, T.; Hashiguchi, Y.

    2000-01-01

    monitor was confirmed through a series of intercomparison experiments, with an error of less than ±20%. The estimated concentrations of thoron progeny from the results of the deposition rate monitors were consistent with the directly measured results by the ECC monitors within ±15%. A small one year survey of indoor thoron and its progeny concentrations was performed in 13 randomly selected dwellings around Nagoya in mid-Japan. Evaluated concentrations of thoron and its progeny were observed in the traditional Japanese house (timber frame and soil wall), the same result had also been reported by other researchers. It suggested that the public exposure to thoron and its progeny should not be neglected in Japan. For assessment of the public exposure to thoron and its progeny, the integrating measuring methods mentioned above may be suitable, but further studies are still needed to improve the measuring accuracy. (author)

  13. Cellular lung dosimetry for inhaled thoron progeny: comparison with radon progeny

    International Nuclear Information System (INIS)

    Abd El-Hady, M.; Hofmann, W.; Balashazy, I.

    1998-01-01

    Recently an analytical method was developed to compute radiation doses deposited by 222 Rn progeny alpha particles in 1 μm spheres located at different depths in bronchial epithelium. The same method was now applied to alpha particles emitted from 220 Rn progeny deposited in bronchial airway surfaces. Results of the computations are presented in graphs. The mean cellular doses imparted by 220 Rn progeny to basal and secretory cell nuclei were compared with those produced by 222 Rn progeny; due to differences in alpha energies, radon progeny doses were found to be generally higher than those for thoron progeny. (A.K.)

  14. Development of an integrated sampler based on direct 222Rn/220Rn progeny sensors in flow-mode for estimating unattached/attached progeny concentration

    International Nuclear Information System (INIS)

    Mishra, Rosaline; Sapra, B.K.; Mayya, Y.S.

    2009-01-01

    A flow-mode integrated sampler consisting of a wire-mesh and filter-paper array along with passive solid state nuclear track detectors has been developed for estimating unattached and attached fraction of 222 Rn/ 220 Rn progeny concentration. The essential element of this sampler is the direct 222 Rn/ 220 Rn progeny sensor (DRPS/DTPS), which is an absorber-mounted-LR115 type nuclear track detector that selectively registers the alpha particles emitted from the progeny deposited on its surface. During sampling at a specified flow-rate, the unattached progeny is captured on the wire-mesh; while the attached progeny gets transmitted and is captured on the filter-paper. The alpha particles emitted by the deposited progeny atoms are registered on the sensors placed at a specified distance facing the wire-mesh and the filter-paper, respectively. The various steps involved in the development of this flow-mode direct progeny sampler such as the optimization of the sampling rate and the distance between the sensor and the deposition substrate are discussed. The sensitivity factor of the DTPS-loaded sampler for 220 Rn progeny deposited on the wire-mesh and filter-paper is found to be 23.77 ± 0.64 (track cm -2 h -1 ) (Bq m -3 ) -1 and 22.30 ± 0.18 (track cm -2 h -1 ) (Bq m -3 ) -1 , respectively; while that of DRPS-loaded sampler for 222 Rn progeny deposition, is 3.03 ± 0.14 (track cm -2 h -1 ) (Bq m -3 ) -1 and 2.08 ± 0.07 (track cm -2 h -1 ) (Bq m -3 ) -1 , respectively. The highlight of this flow-mode sampler is its high sensitivity and that it utilizes the passive technique for estimating the unattached and attached progeny concentration, thus doing away with the alpha counting procedures.

  15. Radon and thoron progeny measurements using a portable radon sniffer

    International Nuclear Information System (INIS)

    Efendi, Z.; Jennings, P.

    1993-01-01

    A flexible version of the two-count method has been developed for use in rapid, inexpensive measurements of radon and thoron progeny working levels in residential and industrial premises in the Perth Metropolitan Area. The Method is adapted for use with a simple radon sniffer based on a low speed pump and an alpha counter. The flexibility of the method derives from the software, where some freedom is permitted in the selection of sampling times and post sampling analysis of the filters. This method has been tested on a variety of radioactive materials and it gives consistent, reliable results over a wide range of working levels. The results of a survey of Rn(222) and Rn(220) progeny levels in dwellings within the Perth Metropolitan Area are reported. This study shows that the mean concentration of indoor Rn(222) progeny was 4.7 mWL (17.4 Bq m -3 EEC) up to 23.3 mWL (86.4 Bq m -3 EEC). The mean thoron progeny concentration was 8.2 mWL (2.25 Bq m -3 EEC) with a range from 1 mWL (0.27 Bq m -3 EEC) to 64.5 mWL (17.74 Bq m -3 EEC). Using conversion factors of 0.061 mSv Bq -1 m -3 for Rn(222) progeny and 0.29 mSv Bq -1 m -3 for Rn(220) progeny respectively (UNSCEAR, 1982), it is estimated the average annual effective dose equivalent is 1.1 mSv for Rn(2220 and 0.6 mSv for Rn(220) respectively. 22 refs., 4 tabs., 1 fig

  16. Study on Quality Improvement Effect and Separate Character of Soybean Male Sterile (MS1) Recurrent Selection Population

    Institute of Scientific and Technical Information of China (English)

    ZHAO Shuang-jin; ZHANG Meng-chen; JIANG Chun-zhi; YANG Chun-yan; LIU Bing-qiang; CUI Jue

    2007-01-01

    To solve the problem that soybean has narrow genetic base, we constructed a series of male sterile recurrent selection populations, and studied the effects of quality improvement and practical value. An LD-base population, which fits to our ecology type was constructed by 6 years' gene enrichment through the introduction of new genes from 23 local varieties and recurrent selection. The LD-base populations were then improved by making crosses with high protein and high oil genotypes. As a result we obtained a high protein sub-population (db) and a high oil sub-population (gy). For the db sub-population, the protein content is 1.18% higher than the base population, 22.38% of the individuals contain 45% or more of protein, which is 10.99% higher than the base population. For the gy sub-population, oil content is 0.24% higher than the base population. Individuals with oil content of 20% or more are 11.05% higher than the base population. The quantitative characters such as flowering date, mature date, pod habit, and hilum color, etc., all showed wide range of separation, and the segregation ratio approached balance. The c.v. of branch number of ms1 recurrent population (72.8%) is higher than general cross-population (57.3%), and the c.v. of 100 seed weight of ms1 (18.1%) is higher than general cross population (16.5%), the coefficient of variation of plant height, pods per plant, and seeds per pod were not significantly different. It was demonstrated in this paper that the quality character of ms1 male sterile recurrent selection population was improved by adding new genes. And the segregation of other characters widened, making the populations suitable for the objective of soybean breeding. In this paper, we also discussed the breeding method, key technology, and selection effect of soybean ms1 population.

  17. Seleção para a resistência à ferrugem em progênies das cultivares de café IPR 99 e IPR 107 Selection for resistance to rust in progenies of coffee cultivars IPR 99 and IPR 107

    Directory of Open Access Journals (Sweden)

    Gustavo Hiroshi Sera

    2010-01-01

    Full Text Available As cultivares de café IPR 99 ("Sarchimor" e IPR 107 ('IAPAR 59' x 'Mundo Novo IAC 376-4' eram no passado resistentes à ferrugem (Hemileia vastatrix. Os objetivos deste estudo foram: a Identificar progênies dessas duas cultivares com resistência à ferrugem; b Identificar progênies com resistência incompleta; c Verificar a eficiência dos cruzamentos testes na seleção dessas cultivares. A avaliação da resistência em campo foi realizada em cafeeiros adultos expostos à população local de raças presentes no IAPAR. Foram avaliados 23 cruzamentos testes com progênies F3 de 'IPR 107' e 5 com progênies F4 de 'IPR 99'. Além disso, foram avaliadas 11 progênies F4 de 'IPR 107' e 5 progênies F5 de 'IPR 99', provenientes de autofecundação. Várias progênies das cultivares IPR 99 e 107 apresentaram alta freqüência de plantas com resistência completa e são portadoras de mais genes de resistência não quebrados pelas raças de ferrugem. Progênies das cultivares IPR 99 e IPR 107 com a resistência quebrada apresentaram resistência incompleta à população local de raças. Cruzamentos testes foram eficientes na seleção de progênies de café com mais genes de resistência não quebrados.All plants of the coffee cultivars IPR 99 ("Sarchimor" and IPR 107 ('IAPAR 59' x 'Mundo Novo IAC 376-4' were resistant to rust (Hemileia vastatrix in the past. Currently, susceptible plants were observed in the two cultivars due to the breakdown of resistance by new rust races. The aims of this study were: a to identify coffee (Coffea arabica L. progenies of the two cultivars with resistance to rust; b to identify progenies with incomplete resistance; c to investigate the efficiency of test-crosses for selection from these cultivars. Evaluation for field resistance was carried out in adult plants subjected to natural infection by the local leaf rust population at IAPAR. Twenty-three test-crosses with F3 progenies of 'IPR 107' and five with F4

  18. Radon progeny distribution in cylindrical diffusion chambers

    International Nuclear Information System (INIS)

    Pressyanov, Dobromir S.

    2008-01-01

    An algorithm to model the diffusion of radioactive decay chain atoms is presented. Exact mathematical solutions in cylindrical geometry are given. They are used to obtain expressions for the concentrations of 222 Rn progeny atoms in the volume and deposited on the wall surface in cylindrical diffusion chambers. The dependence of volume fractions of 222 Rn progeny and chamber sensitivity on the coefficient of diffusion of 222 Rn progeny atoms in air is modeled.

  19. Non-tricyclic and Non-selective Serotonin Reuptake Inhibitor Antidepressants and Recurrent Falls in Frail Older Women.

    Science.gov (United States)

    Naples, Jennifer G; Kotlarczyk, Mary P; Perera, Subashan; Greenspan, Susan L; Hanlon, Joseph T

    2016-12-01

    To determine the risk of recurrent falls associated with antidepressants other than tricyclics (TCAs) and selective serotonin reuptake inhibitors (SSRIs) among frail older women. This is a secondary analysis of the Zoledronic acid in frail Elders to STrengthen bone, or ZEST, trial data treated as a longitudinal cohort in 181 frail, osteoporotic women aged ≥65 years in long-term care. The primary exposure was individual non-TCA/non-SSRI antidepressants (i.e., serotonin norepinephrine reuptake inhibitors, mirtazapine, trazodone, and bupropion) at baseline and 6 months. The main outcome was recurrent (at least two) falls within 6 months after antidepressant exposure. Adjusted odds ratios (AORs) and 95% confidence intervals (CIs) were derived using a generalized estimating equations model. At least 15% of women experienced recurrent falls between 0-6 and 6-12 months. At baseline and 6 months, 18.2% and 6.9% had a non-TCA/non-SSRI antidepressant, respectively. Adjusting for demographics, health status, and other drugs that increase risk of falls, non-TCA/non-SSRI antidepressant exposure significantly increased the risk of recurrent falls (AOR: 2.14; 95% CI: 1.01-4.54). Fall risk further increased after removing bupropion from the non-TCA/non-SSRI antidepressant group in sensitivity analyses (AOR: 2.73; 95% CI: 1.24-6.01). Other antidepressant classes may not be safer than TCAs/SSRIs with respect to recurrent falls in frail older women. Copyright © 2016 American Association for Geriatric Psychiatry. Published by Elsevier Inc. All rights reserved.

  20. Radon Progeny in Egyptian Underground Phosphate Mines

    International Nuclear Information System (INIS)

    El-Hady, M.A.; Mohammed, A.; El-Hussein, A.; Ali, A.E.; Ahmed, A.A.

    2001-01-01

    In addition to the workers in uranium mines, the staff of other underground mines, such as workers in underground phosphate mines, can be exposed to 222 Rn and its progeny. In this study the individual radon progeny concentrations were measured in three Egyptian underground phosphate mines to estimate the occupational exposure of the workers at those sites. A filter method was used to measure individual radon progeny concentrations ( 218 Po, 214 Pb and 214 Po). The reported mean values of radon progeny concentrations exceed the action levels which are recommended by ICRP 65 (1993). Based on the measured individual radon progeny concentrations ( 218 Po, 214 Pb and 214 Po) in these mines, the annual effective dose for the workers has been calculated using the lung dose model of ICRP 66 (1994). According to the obtained results, some countermeasures were recommended in this study to minimise these exposure levels. (author)

  1. Interaction of radon progeny with atmospheric aerosols

    International Nuclear Information System (INIS)

    Morawska, Lidia

    1994-01-01

    The radiological health hazard due to the airborne radon progeny depends on three factors (i) radon concentration in the air, (ii) radon progeny concentration, and (iii) active particle size distribution. Conclusions as to the health hazard cannot be drawn without full understanding of the interaction mechanisms between radon progeny and atmospheric aerosols. The aim of this work was to study the interaction mechanisms between radon progeny, natural environmental aerosols and environmental tobacco smoke (ETS). The experiments were performed under controlled laboratory conditions of radon concentration (1.85 and 3.70 Bq m -3 ), relative humidity (35, 50, 75 and 95%) and ETS generation. The size distribution of radioactivity carrying aerosols was measured using a wire screen diffusion battery system and size distribution of all airborne aerosols using a differential mobility particle sizer. The paper presents and discusses the results of activity size distribution and radon progeny concentration measurements for different environmental conditions. 7 refs., 2 tabs

  2. Health effects of inhaled radon progeny

    International Nuclear Information System (INIS)

    Monchaux, G.

    1997-01-01

    The relationship between an increased risk of lung cancer and exposure to radon progeny has been studied in eleven cohorts of underground workers, both in uranium and non uranium mines as well as in experimental animals. Risk estimates derived from miners studies are used to assess the risk of lung cancer in relation to exposure to indoor radon progeny. Human and animal experimental data are reviewed in the perspective of risk assessment for low exposure to radon progeny, in the conditions of the contemporary working environment as well as the indoor domestic environment. (authors)

  3. RELATIONSHIP BETWEEN YIELD AND FRUIT QUALITY OF PASSION FRUIT C03 PROGENIES UNDER DIFFERENT NUTRITIONAL LEVELS

    Directory of Open Access Journals (Sweden)

    CARLOS LACY SANTOS

    Full Text Available ABSTRACT The present study was conducted to evaluate different fertilization-management strategies in ten progenies of passion fruit from the third recurrent selection cycle and their effects on yield and fruit-quality traits. For this purpose, we adopted the strategy of correlations analysis, using the phenotypic and path correlations in different environmental conditions characterized by three levels of fertilization. The trial was set up as a randomized-block design in a split-plot arrangement with progenies representing the plots and three levels of potassium-nitrogen fertilization as the sub-plots, with three replicates. Path analysis showed that number of fruits was the variable of highest correlation with fruit diameter at fertilization I. Fruit weight and pulp weight were correlated with each other and with other traits like fruit length and fruit diameter at the three fertilization levels, except for number of fruits, which was correlated with nitrogen and potassium only at fertilization II. Path analysis also revealed that fruit diameter (3.125 showed the highest direct effect on yield at fertilization I. However, fruit weight and number of fruits showed, at fertilization II, the highest direct effects of 2.964 and 1.134 on yield, respectively, and number of fruits had a high phenotypic correlation and direct effect on yield at the three fertilization levels: 0.528 at fertilization I; 2.206 at fertilization II; and 0.928 at fertilization III. The results demonstrate the greater direct effect obtained with fertilization II, suggesting that the level adopted at fertilization II can provide satisfactory gains in yield and is thus recommended for the population in question.

  4. Recurrent balanoposthitis of mixed etiology: relation to oral sex and selection of an efficient treatment method

    Directory of Open Access Journals (Sweden)

    O. B. Demianova

    2014-01-01

    Full Text Available Goal. To study the dependence between the recurrent balanoposthitis of mixed etiology and oral sex. To assess the efficacy, tolerance and cosmetic acceptability of a combination topical drug on the basis of a cream for the treatment of balanoposthitis of Candida and bacterial etiology. Materials and methods. An open-label single-arm non-randomized study involved 48 men aged 22-43 suffering from recurrent balanoposthitis of mixed etiology and their long-term sex partners. All of the subjects underwent the following tests: complete blood count, clinical urine test, blood biochemistry (AST, ALT, total bilirubin, thymol test and blood glucose, MRSA, blood tests for anti-hepatitis B and C virus antibodies, HIV-1/-2 antibody screening test, microscopy of urethral, vaginal and cervical canal materials, PCR for Chlamydia trachomatis, Trichomonas vaginalis, N. gonorrhoeae, Mycoplasma genitalium, Ureaplasma spp, bacterial swab tests based on urethral materials (in men, vaginal materials (in women and throat (in subjects of both sexes, and microscopy of tongue scrapings. 46 male patients used the Candiderm cream (Glenmark Pharmaceuticals Ltd. for 10-14 days. Physicians assessed the efficacy based on the symptom intensity and patient’s opinion. Results. In people who practiced unprotected oral sex, a high contamination of mucous coats in the oral cavity, throat and genitals with yeast fungi and opportunistic bacteria was revealed. C. Аlbicans was often found in diagnostically significant amounts in couples. The authors substantiate the possibility of a contact-type transmission of opportunistic bacteria during oral sex resulting in balanoposthitis of mixed Candida and bacterial etiology or exacerbation of their condition after sexual contacts in men practicing unprotected oral sex. Evident clinical efficacy and safety of the combination as well as good tolerance and convenience of application of the combination topical drug comprising beclomethasone

  5. Prediction of direct and indirect genetic gains and genotypic correlations in rubber tree progenies

    Directory of Open Access Journals (Sweden)

    Cecília Khusala Verardi

    2011-09-01

    Full Text Available The objective of this work was to estimate the genetic parameters, genotypic and phenotypic correlations, and direct and indirect genetic gains among and within rubber tree (Hevea brasiliensis progenies. The experiment was set up at the Municipality of Jaú, SP, Brazil. A randomized complete block design was used, with 22 treatments (progenies, 6 replicates, and 10 plants per plot at a spacing of 3x3 m. Three‑year‑old progenies were assessed for girth, rubber yield, and bark thickness by direct and indirect gains and genotypic correlations. The number of latex vessel rings showed the best correlations, correlating positively and significantly with girth and bark thickness. Selection gains among progenies were greater than within progeny for all the variables analyzed. Total gains obtained were high, especially for girth increase and rubber yield, which were 93.38 and 105.95%, respectively. Young progeny selection can maximize the expected genetic gains, reducing the rubber tree selection cycle.

  6. Progeny testing: proceedings of servicewide genetics workshop

    Science.gov (United States)

    Dick Miller

    1984-01-01

    The primary objective of this workshop was to discuss in detail the state- of-the-art of progeny testing. All aspects, from setting objectives through data collection and analysis, was be covered. We all know progeny testing is a highly technical phase of our tree improvement programs. Each task is critical and must be performed accurately and within a prescribed time...

  7. Assessing hybrid sterility in Oryza glaberrima x O. sativa hybrid progenies by PCR marker analysis and crossing with wide compatibility varieties.

    Science.gov (United States)

    Heuer, Sigrid; Miézan, Kouamé M

    2003-09-01

    Interspecific crossing of the African indigenous rice Oryza glaberrima with Oryza sativa cultivars is hindered by crossing barriers causing 100% spikelet sterility in F(1) hybrids. Since hybrids are partially female fertile, fertility can be restored by back crossing (BC) to a recurrent male parent. Distinct genetic models on spikelet sterility have been developed predicting, e.g., the existence of a gamete eliminator and/or a pollen killer. Linkage of sterility to the waxy starch synthase gene and the chromogen gene C, both located on chromosome 6, have been demonstrated. We selected a segregating BC(2)F(3) population of semi-sterile O. glaberrima x O. sativa indica hybrid progenies for analyses with PCR markers located at the respective chromosome-6 region. These analyses revealed that semi-sterile plants were heterozygous for a marker (OSR25) located in the waxy promoter, whereas fertile progenies were homozygous for the O. glaberrima allele. Adjacent markers showed no linkage to spikelet sterility. Semi-sterility of hybrid progenies was maintained at least until the F(4) progeny generation, suggesting the existence of a pollen killer in this plant material. Monitoring of reproductive plant development showed that spikelet sterility was at least partially due to an arrest of pollen development at the microspore stage. In order to address the question whether genes responsible for F(1) sterility in intraspecific hybrids ( O. sativa indica x japonica) also cause spikelet sterility in interspecific hybrids, crossings with wide compatibility varieties (WCV) were performed. WCV accessions possess "neutral" S-loci ( S(n)) improving fertility in intraspecific hybrids. This experiment showed that the tested S(n)-loci had no fertility restoring effect in F(1) interspecific hybrids. Pollen development was completely arrested at the microspore stage and grains were never obtained after selfing. This suggests that distinct or additional S-loci are responsible for sterility

  8. Radon progeny mitigation using unipolar ion generators

    International Nuclear Information System (INIS)

    Sapra, B.K.; Arun Kumar; Khan, Arshad; Kothalkar, P.S.; Mayya, Y.S.

    2006-01-01

    Unipolar ion generators are often used for reduction of particulate levels in indoor environments. This paper explores the feasibility of their use in reducing radon progeny concentrations in a confined environment. Experiments have been carried out in a 10 m 3 test vessel in which ionizers are suspended in airspace and 226 Ra planchettes are placed as sources of radon. The radon, progeny and aerosol concentrations were estimated prior to and post-ioniser operation in the vessel using standard instruments and techniques. Results showed that the progeny concentrations decreased by a factor of about 10 with a mean life of about 35 min after ioniser was switched on. A mathematical model involving progeny, particle, ion space charge and electric field interaction processes been developed for estimating the various fractions of the progeny concentrations in the presence of the ionizer. The results of the model compared well with the experimental results. This study has a possible application for reducing progeny concentrations in U mines at local scales and specific working areas. (author)

  9. Genetic gain prediction on UNB-2U popcorn population under recurrent selection by using different selection indexes / Predição de ganhos genéticos na população de milho pipoca UNB-2U sob seleção recorrente utilizando-se diferentes índices de seleção

    Directory of Open Access Journals (Sweden)

    Alexandre Pio Viana

    2009-12-01

    Full Text Available Aiming to estimate the gain prediction by using selection indexes on cycle C4 of UNB-2U, two hundred progenies of full-sib families were obtained on the third cycle under recurrent selection. The progenies were evaluated in a randomized complete block design with two replications within sets, in two distinct environments: Colégio Estadual Agrícola Antônio Sarlo, located in Campos dos Goytacazes, and Experimental Station of PESAGRO-Rio, located in Itaocara, Rio de Janeiro State. The utilized selection indexes were the Smith (1936 and Hazel (1943, Pesek and Baker (1969, Williams (1962, and Mulamba and Mock (1978. The selection index of Mulamba and Mock (1978 allowed the prediction of negative gains for number of disease ears, number of ears attacked by insects, number of broken plants, poorly hulled ears; and it provided superior gains for popcorn expansion and grain yield, with values of 10.55% and 8.50%, respectively, in the use of arbitrary weights attributed by tentative.Com o intento de estimar a predição de ganhos por índices de seleção no ciclo C4 de UNB-2U, duzentas famílias de irmãos-completos foram obtidas a partir da população de terceiro ciclo de seleção recorrente. As progênies foram avaliadas no delineamento de blocos casualizados com duas repetições dentro de ‘‘sets’’ em dois ambientes distintos: Colégio Estadual Agrícola Antônio Sarlo, em Campos dos Goytacazes, e Estação Experimental da PESAGRO-RIO, em Itaocara, Rio de Janeiro. Os índices de seleção empregados para predizer os ganhos foram os de Mulamba e Mock (1978, Pesek e Baker (1969, Smith (1936 e Hazel (1943 e Williams (1962. O índice de seleção Mulamba e Mock (1978 além de permitir a predição de ganhos negativos para número de espigas doentes e atacadas por pragas, número de plantas quebradas e acamadas, e espigas mal empalhadas; para capacidade de expansão e rendimento dos grãos, proporcionou ganhos superiores aos demais

  10. Seleção de progênies de erva-mate (Ilex paraguariensis St. Hill. para a produtividade, estabilidade e adaptabilidade temporal de massa foliar Selection of Erva-mate Progenies for Leaf Weight Productivity, Temporal Stability and Adaptability

    Directory of Open Access Journals (Sweden)

    José Alfredo Sturion

    2011-03-01

    Full Text Available O presente trabalho teve por objetivos selecionar progênies de erva-mate (Ilex paraguariensis St. Hil.  em Ivaí - PR, simultaneamente para estabilidade, adaptabilidade e produtividade de massa foliar,  colhidas em três safras, com base na média harmônica a performance relativa dos valores genéticos (MHPRVG, adicionalmente, comparar os resultados  com aqueles obtidos pelos métodos de Annicchiarico e  de Lin & Binns. O material genético consistiu de 25  progênies de meios-irmãos plantadas no delineamento  de blocos ao acaso, com dez repetições  e parcelas lineares de seis plantas no espaçamento de  3m x 2m. O peso de folhas foi avaliado, por árvore,  aos dois, quatro e seis anos após o plantio. Houve  uma alteração no ordenamento das progênies para a produção de massa foliar ao longo das safras. Os  métodos de Annicchiarico, Lin & Binns e MHPRVG  selecionaram, praticamente, as mesmas progênies para os três atributos considerados. Contudo, o método  HPRVG apresenta a vantagem de fornecer  resultados na própria escala e medição do caráter, os quais podem ser interpretados diretamente como  valores genéticos.
    This paper aimed to select progenies of “erva-mate” (Ilex paraguariensis St. HiI. in Ivai - PR based on leaf weight productivity, stability and adaptability across three harvests. This can be achieved by the method MHPRVG (harmonic average of relative performance of genetic values which is comparable with the methods by Annichiaricco and Lin & Binns. The genetic material was constituted by 25 half sib progenies evaluated in a complete block design with ten replicates and six plants per plot, in a 3 x 2 meters spacing. Leaf weight per tree  was evaluated at ages two, four and six years  after planting. There were some changes in progenies  ranking across harvests. The methods MHPRVG, Annichiaricco and Lin & Binns led to selection of the  same progenies, considering the three

  11. Possibilidade de seleção recorrente para aumento do teor de óleo em soja com a utilização da macho-esterilidade genética e da espectroscopia de ressonância nuclear magnética The possibility of recurrent selection to increase the oil content in soybeans using genetic male sterility and NMR spectroscopy

    Directory of Open Access Journals (Sweden)

    Manoel Albino Coelho de Miranda

    1989-01-01

    Full Text Available Com a finalidade de estudar a possibilidade de realizar seleção recorrente, analisaram-se sementes de soja de plantas macho-estéreis e de sua progênies quanto ao teor de óleo no espectroscópio de ressonância nuclear magnética (NMR, no Instituto de Física da Universidade de Campinas de 1984 a 1988. Tais sementes provinham do composto IAC-1, com macho-esterilidade genética e ampla variabilidade quanto à percentagem de óleo (13,5-22,5%. Determinaram-se os coeficientes de repetibilidade, tomando-se o teor de óleo de cada semente da planta macho-estéril como uma medida fenotípica, obtendo-se o valor médio de r = 0,65. Concluiu-se que com a análise de quatro a cinco sementes, é possível representar a planta-mãe, passo importante para viabilizar a seleção recorrente nessa população, visto o pequeno número de sementes produzidas por planta macho-estéril. Utilizando-se a covariância entre a média das sementes da planta macho-estéril e a média de suas progênies, obteve-se h² = 0,73. Essa herdabilidade é alta, e como o caráter teor de óleo tem como principal componente de sua variância genética a variância aditiva, pode-se recomendar a seleção fenotípica. Calculou-se também o coeficiente de herdabilidade no nível da média de progênies, obtendo-se valores desde 0,66, para a média de duas plantas por progênie, até 0,85, para a de sete plantas por progênie. Esses resultados demonstram a possibilidade de seleção recorrente no composto IAC-1, tanto no campo, ao nível de planta macho-estéril, como em casa de vegetação, em seleção baseada na média da progênie.The seed oil content of male sterile plants and their progenies was analised by a NMR spectroscope to study the possibility of recurrent selection to improve the oil content. The seeds derived from a composite named "IAC-1" with genetic male sterility and large variability with respect to oil content. The repeatability coefficient (r for oil content

  12. Análise biométrica de ganhos por seleção em população de milho pipoca de quinto ciclo de seleção recorrente Biometric analysis of selection gains in popcorn population of the fifth cycle of recurrent selection

    Directory of Open Access Journals (Sweden)

    Ramon Macedo Rangel

    2011-06-01

    Full Text Available Com o intento de selecionar progênies superiores para a efetiva concentração de alelos favoráveis em uma população de quinto ciclo de seleção recorrente intrapopulacional em famílias de irmãos-completos de milho pipoca, avaliaram-se 200 famílias quanto a seis características agronômicas, incluindo rendimento de grãos e capacidade de expansão, em delineamento aleatorizado em blocos com duas repetições dentro de 'sets' em dois ambientes distintos: Colégio Estadual Agrícola Antônio Sarlo, em Campos dos Goytacazes, e Estação Experimental da PESAGRO-RIO, em Itaocara, Rio de Janeiro, em 2007/2008. Houve diferenças significativas para famílias/"sets" para todas as características, indicando a presença de variabilidade genética a ser explorada nos futuros ciclos. Na seleção das progênies superiores o índice de Mulamba e Mock resultou em ganhos proporcionais mais adequados para capacidade de expansão e rendimento de grãos, com valores respectivos de 6,01 e 8,53%, na utilização de pesos econômicos arbitrários.Aiming to select superior progenies for concentration of favorable alleles in a popcorn population on the fifth cycle of intrapopulation full-sib recurrent selection, two hundred progenies were evaluated for six agronomic traits, including grain yield and popping expansion, in randomized complete block design with two replications within sets, in two distinct environments: Colégio Estadual Agrícola Antônio Sarlo, in Campos dos Goytacazes, and Experimental Station of PESAGRO-RIO, located in Itaocara, Rio de Janeiro State, in 2007/2008. There were significant differences among families within sets in all traits, indicating the presence of genetic variability to be exploited in the future cycles. The utilized selection indexes were the Mulamba and Mock; and Smith and Hazel. The Mulamba and Mock index propitiated more elevated magnitudes of the predicted gains for most of the traits, including popping expansion and

  13. Dosimetry of inhaled radon and thoron progeny

    International Nuclear Information System (INIS)

    James, A.C.

    1994-06-01

    This chapter reviews recent developments in modeling doses received by lung tissues, with particular emphasis on application of ICRP's new dosimetric model of the respiratory tract for extrapolating to other environments the established risks from exposure to radon progeny in underground mines. Factors discussed include: (1) the influence of physical characteristics of radon progeny aerosols on dose per unit exposure, e.g., the unattached fraction, and the activity-size distributions of clustered and attached progeny; (2) the dependence of dose on breathing rate, and on the exposed subject (man, woman or child); (3) the variability of dose per unit exposure in a home when exposure is expressed in terms of potential α energy or radon gas concentration; (4) the comparative dosimetry of thoron progeny; and (5) the effects of air-cleaning on lung dose. Also discussed is the apparent discrepancy between lung cancer risk estimates derived purely from dosimetry and the lung cancer incidence observed in the epidemiological studies of radon-exposed underground miners. Application of ICRP's recommended risk factors appears to overestimate radon lung-cancer risk for miners by a factor of three. ''Normalization'' of the calculated effective dose is therefore needed, at least for α dose from radon and thoron progeny, in order to obtain a realistic estimate of lung cancer risk

  14. Field investigation of surface-deposited radon progeny as a possible predictor of the airborne radon progeny dose rate.

    Science.gov (United States)

    Sun, Kainan; Steck, Daniel J; Field, R William

    2009-08-01

    The quantitative relationships between radon gas concentration, the surface-deposited activities of various radon progeny, the airborne radon progeny dose rate, and various residential environmental factors were investigated through actual field measurements in 38 selected Iowa houses occupied by either smokers or nonsmokers. Airborne dose rate was calculated from unattached and attached potential alpha energy concentrations (PAECs) using two dosimetric models with different activity-size weighting factors. These models are labeled Pdose and Jdose, respectively. Surface-deposited 218Po and 214Po were found significantly correlated to radon, unattached PAEC, and both airborne dose rates (p fireplace, or usage of a ceiling fan significantly, or marginally significantly, reduced the Pdose to 0.65 (90% CI 0.42-0.996), 0.54 (90% CI 0.28-1.02), and 0.66 (90% CI 0.45-0.96), respectively. For Jdose, only the usage of a ceiling fan significantly reduced the dose rate to 0.57 (90% CI 0.39-0.85). In smoking environments, deposited 218Po was a significant negative predictor for Pdose (RR 0.68, 90% CI 0.55-0.84) after adjusting for long-term 222Rn and environmental factors. A significant decrease of 0.72 (90% CI 0.64-0.83) in the mean Pdose was noted, after adjusting for the radon and radon progeny effects and other environmental factors, for every 10 additional cigarettes smoked in the room. A significant increase of 1.71 in the mean Pdose was found for large room size relative to small room size (90% CI 1.08-2.79) after adjusting for the radon and radon progeny effects as well as other environmental factors. Fireplace usage was found to significantly increase the mean Pdose to 1.71 (90% CI 1.20-2.45) after adjusting for other factors.

  15. Selective Embolization of Systemic Collaterals for the Treatment of Recurrent Hemoptysis Secondary to the Unilateral Absence of a Pulmonary Artery in a Child

    Energy Technology Data Exchange (ETDEWEB)

    Zhou, Yin, E-mail: zhouyin502@163.com [West China Hospital, Sichuan University, Department of Pediatric Surgery (China); Tsauo, Jiaywei, E-mail: 80732059@qq.com [West China Hospital, Sichuan University, Institute of Interventional Radiology (China); Li, Yuan, E-mail: liyuanletters@163.com [West China Hospital, Sichuan University, Department of Pediatric Surgery (China); Li, Xiao, E-mail: simonlixiao@gmail.com [West China Hospital, Sichuan University, Institute of Interventional Radiology (China)

    2015-10-15

    The unilateral absence of the pulmonary artery (UAPA) is a rare anomaly. Hemoptysis due to systemic collaterals is one of the most common complications of UAPA. To the best of the authors’ knowledge, the utility of selective embolization for the treatment of this condition in children has not been reported previously. This report describes a 6-year-old girl with isolated UAPA (IUAPA) admitted for a 10-month history of recurrent hemoptysis that had worsened during the previous 2 months. Selective embolization of the bronchial systemic collaterals was performed. The patient remained asymptomatic with no recurrence of hemoptysis 8 months after the procedure.

  16. Recurrent Intracerebral Hemorrhage

    DEFF Research Database (Denmark)

    Schmidt, Linnea Boegeskov; Goertz, Sanne; Wohlfahrt, Jan

    2016-01-01

    BACKGROUND: Intracerebral hemorrhage (ICH) is a disease with high mortality and a substantial risk of recurrence. However, the recurrence risk is poorly documented and the knowledge of potential predictors for recurrence among co-morbidities and medicine with antithrombotic effect is limited....... OBJECTIVES: 1) To estimate the short- and long-term cumulative risks of recurrent intracerebral hemorrhage (ICH). 2) To investigate associations between typical comorbid diseases, surgical treatment, use of medicine with antithrombotic effects, including antithrombotic treatment (ATT), selective serotonin...

  17. High Correlated Paternity Leads to Negative Effects on Progeny Performance in Two Mediterranean Shrub Species.

    Directory of Open Access Journals (Sweden)

    Sofia Nora

    Full Text Available Anthropogenic habitat deterioration can promote changes in plant mating systems that subsequently may affect progeny performance, thereby conditioning plant recruitment for the next generation. However, very few studies yet tested mating system parameters other than outcrossing rates; and the direct effects of the genetic diversity of the pollen received by maternal plants (i.e. correlated paternity has often been overlooked. In this study, we investigated the relation between correlated paternity and progeny performance in two common Mediterranean shrubs, Myrtus communis and Pistacia lentiscus. To do so, we collected open-pollinated progeny from selected maternal plants, calculated mating system parameters using microsatellite genotyping and conducted sowing experiments under greenhouse and field conditions. Our results showed that some progeny fitness components were negatively affected by the high correlated paternity of maternal plants. In Myrtus communis, high correlated paternity had a negative effect on the proportion and timing of seedling emergence in the natural field conditions and in the greenhouse sowing experiment, respectively. In Pistacia lentiscus, seedling emergence time under field conditions was also negatively influenced by high correlated paternity and a progeny survival analysis in the field experiment showed greater mortality of seedlings from maternal plants with high correlated paternity. Overall, we found effects of correlated paternity on the progeny performance of Myrtus communis, a self-compatible species. Further, we also detected effects of correlated paternity on the progeny emergence time and survival in Pistacia lentiscus, an obligate outcrossed species. This study represents one of the few existing empirical examples which highlight the influence that correlated paternity may exert on progeny performance in multiple stages during early seedling growth.

  18. On the use of sibling recurrence risks to select environmental factors liable to interact with genetic risk factors.

    Science.gov (United States)

    Kazma, Rémi; Bonaïti-Pellié, Catherine; Norris, Jill M; Génin, Emmanuelle

    2010-01-01

    Gene-environment interactions are likely to be involved in the susceptibility to multifactorial diseases but are difficult to detect. Available methods usually concentrate on some particular genetic and environmental factors. In this paper, we propose a new method to determine whether a given exposure is susceptible to interact with unknown genetic factors. Rather than focusing on a specific genetic factor, the degree of familial aggregation is used as a surrogate for genetic factors. A test comparing the recurrence risks in sibs according to the exposure of indexes is proposed and its power is studied for varying values of model parameters. The Exposed versus Unexposed Recurrence Analysis (EURECA) is valuable for common diseases with moderate familial aggregation, only when the role of exposure has been clearly outlined. Interestingly, accounting for a sibling correlation for the exposure increases the power of EURECA. An application on a sample ascertained through one index affected with type 2 diabetes is presented where gene-environment interactions involving obesity and physical inactivity are investigated. Association of obesity with type 2 diabetes is clearly evidenced and a potential interaction involving this factor is suggested in Hispanics (P=0.045), whereas a clear gene-environment interaction is evidenced involving physical inactivity only in non-Hispanic whites (P=0.028). The proposed method might be of particular interest before genetic studies to help determine the environmental risk factors that will need to be accounted for to increase the power to detect genetic risk factors and to select the most appropriate samples to genotype.

  19. Eficiência da seleção recorrente para redução da estatura de plantas em mamoneira (Ricinus communis L. Recurrent selection efficiency for stature reduction of castor bean (Ricinus communis L. plants

    Directory of Open Access Journals (Sweden)

    Inocencio Junior de Oliveira

    2008-08-01

    Full Text Available Realizou-se, o presente trabalho, com o objetivo de avaliar a eficiência da seleção recorrente para a redução da estatura de plantas de mamona da cultivar Guarani (Ricinus communis L., tornando-a com porte adequado para facilitar a colheita manual e/ou mecânica. Foram realizados quatro ciclos de seleção recorrente com a utilização de progênies autofecundadas na cultivar Guarani para redução da estatura das plantas, nas condições edafoclimáticas dos municípios de São Manuel - SP, Botucatu - SP e Penápolis - SP. As avaliações de estatura das plantas e de produtividade de grãos (kg.ha-1, dos quatro ciclos de seleção e do ciclo original foram realizadas nos municípios de São Manuel - SP, Botucatu - SP e Penápolis - SP na safra 2005/2006, sob um delineamento de blocos casualizados com cinco repetições e parcela útil de 30 m². A análise de variância para as características avaliadas foi feita separadamente para cada local e conjuntamente para os três locais e, posteriormente, realizada a comparação das médias pelo teste de Tukey, a 5%. Foram estimados, para as três localidades, por análise de regressão, os ganhos genéticos dos quatros ciclos de seleção para estatura de plantas. A partir dos resultados obtidos pôde-se concluir que a seleção recorrente foi eficiente para a redução da estatura de plantas e que a cultivar de mamona Guarani apresenta variabilidade genética para essa característica e que a produtividade não foi influenciada pela redução da estatura de plantas.The aim of this work was to evaluate the recurrent selection efficiency for reduction of stature of the castor bean plants of the Guarani cultivar (Ricinus communis L., turning it with appropriate strucuture to facilitate the manual and/or mechanic harvest. Four cycles of recurrent selection were accomplished through the utilization of self-pollinated progenies in the Guarani cultivar for reduction of plants stature, in

  20. Total pancreatectomy for recurrent acute and chronic pancreatitis: a critical review of patient selection criteria

    Science.gov (United States)

    Faghih, Mahya; Gonzalez, Francisco Garcia; Makary, Martin A.; Singh, Vikesh K.

    2018-01-01

    Purpose of review Critical review of the indications for total pancreatectomy and highlight limitations in current diagnostic criteria for chronic pancreatitis. Recent findings The diagnosis of noncalcific chronic pancreatitis remains controversial because of an overreliance on nonspecific imaging and laboratories findings. Endoscopic ultrasound, s-magnetic resonance cholangiopancreatography, and/or endoscopic pancreatic function testing are often used to diagnose noncalcific chronic pancreatitis despite the fact that there is no gold standard for this condition. Abdominal pain is not specific for chronic pancreatitis and is more likely to be encountered in patients with functional gastrointestinal disorders based on the high incidence of these conditions. The duration of pain and opioid analgesic use results in central sensitization that adversely affects pain outcomes after total pancreatectomy. An alcoholic cause is associated with poorer pain outcomes after total pancreatectomy. Summary The lack of a gold standard for noncalcific chronic pancreatitis limits the diagnostic accuracy of imaging and laboratory tests. The pain of chronic pancreatitis is nonspecific and is affected by duration, preoperative opioid use, and cause. These factors will need to be considered in the development of future selection criteria for this morbid surgery. PMID:28700371

  1. Using the Animal Model to Accelerate Response to Selection in a Self-Pollinating Crop

    Science.gov (United States)

    Cowling, Wallace A.; Stefanova, Katia T.; Beeck, Cameron P.; Nelson, Matthew N.; Hargreaves, Bonnie L. W.; Sass, Olaf; Gilmour, Arthur R.; Siddique, Kadambot H. M.

    2015-01-01

    We used the animal model in S0 (F1) recurrent selection in a self-pollinating crop including, for the first time, phenotypic and relationship records from self progeny, in addition to cross progeny, in the pedigree. We tested the model in Pisum sativum, the autogamous annual species used by Mendel to demonstrate the particulate nature of inheritance. Resistance to ascochyta blight (Didymella pinodes complex) in segregating S0 cross progeny was assessed by best linear unbiased prediction over two cycles of selection. Genotypic concurrence across cycles was provided by pure-line ancestors. From cycle 1, 102/959 S0 plants were selected, and their S1 self progeny were intercrossed and selfed to produce 430 S0 and 575 S2 individuals that were evaluated in cycle 2. The analysis was improved by including all genetic relationships (with crossing and selfing in the pedigree), additive and nonadditive genetic covariances between cycles, fixed effects (cycles and spatial linear trends), and other random effects. Narrow-sense heritability for ascochyta blight resistance was 0.305 and 0.352 in cycles 1 and 2, respectively, calculated from variance components in the full model. The fitted correlation of predicted breeding values across cycles was 0.82. Average accuracy of predicted breeding values was 0.851 for S2 progeny of S1 parent plants and 0.805 for S0 progeny tested in cycle 2, and 0.878 for S1 parent plants for which no records were available. The forecasted response to selection was 11.2% in the next cycle with 20% S0 selection proportion. This is the first application of the animal model to cyclic selection in heterozygous populations of selfing plants. The method can be used in genomic selection, and for traits measured on S0-derived bulks such as grain yield. PMID:25943522

  2. Concentration ratio of radon progeny in air

    International Nuclear Information System (INIS)

    Kobayashi, Tsuneo

    2000-01-01

    Investigations have been made on the concentration ratio of radon progeny in air. Data have been acquired intermittently since 1988 using alpha spectroscopic method around the author's office that is located in the northeastern part of Japan. Clarifying the behavior of radon progeny is an issue of wide importance to radiation protection, predicting earthquakes, etc. Let Rabc=ECRn(RaA)/{ECRn(RaB) + ECRn(RaC)}; the concentration ratio, Rabc, is relevant to the stability of the air. Statistical and time series analyses indicated several interesting results. To examine the log-normal distribution, Lilliefors test was made for logarithm of outdoor data every one year. Rabc passed the test 6 times for 9 years, while Radon progeny passed 8 times. Outdoor data indicated that the value of Rabc was lower in the morning, in other world, the air was more stable in the morning than in the afternoon. To see the seasonal variation, one-way layout analysis was made for four groups of data, i.e., spring (March to May), summer (June to August), autumn (September to November), and winter (December to February). Rabc indicated significantly higher level in spring and winter, in other word, air was stable in summer and autumn. Time series analysis was made for various variables; power spectra were estimated with autoregressive model that is equivalent to maximum entropy method. Power spectrum for Rabc was most similar to that of wind speed. One-year period, that is always remarkable for radon progeny, was not significant for Rabc. Three- to nine-day periods were often seen for Rabc, radon progeny, wind speed, and atmospheric pressure. These several-day periods are probably attributed to the passage of air masses. Twenty-day to thirty-day peak may be attributed to meteorological phenomena corresponding to the rotation period of the sun. Temperature indicated no significant periodicity except overwhelming one-year period. Wind speed is well known to affect the radon progeny concentration

  3. Leukemias in the progeny of exposed parents

    International Nuclear Information System (INIS)

    Kosenko, M.M.; Gudkova, N.V.

    1996-01-01

    The purpose of this study was to assess the incidence of leukemias among the progeny of exposed parents. The parents were exposed as a result of discharge of radioactive waste from the Mayak atomic plant into the Techa river in the Southern Urals. The doses per parents gonads, ranging from 0.035 to 1.27 Sv, were due to external exposure in 1950-1956 and to incorporation of Cs-137. Nine cases with leukemia and four with lympohoma were recorded in 13.500 antenatally exposed subjects and descendants of exposed parents over the period of 1950 to 1988. The leukemia morbidity index for the progeny of exposed parents was 2.51, which virtually not statistically differ from that in control group. Refs. 7, figs. 3, tabs. 3

  4. Avaliação e seleção de progênies F3 de cafeeiros de porte baixo com o gene SH3 de resistência a Hemileia vastatrix Berk. et Br. Evaluation and selection of Coffea arabica F3 progenies with low height and the leaf-rust SH3 resistence gene

    Directory of Open Access Journals (Sweden)

    Albano Silva da Conceição

    2005-01-01

    porte baixo portando o gene SH3 de resistência ao agente da ferrugem.The present work evaluated 36 arabic coffee (Coffea arabica L. F3 progenies, originated from crosses among cultivars Catuaí Vermelho IAC 46 and Catuaí Vermelho IAC 81 and access IAC 1110 (BA-10. This last cultivar came from India and exhibits SH2 and SH3 rust resistance genes. The experiment was installed in 1988 at the Experimental Center of the Agronomic Institute (IAC/APTA, in Campinas, using random blocks design with six repetitions and two plants per plot. Field evaluations included yield (average of seven annual harvests, vegetative vigor, resistance to leaf rust, plant size, color of young leaves and complete fruit maturation period. Based on these evaluations, plants exhibiting high yield, good vegetative vigor, low height, and resistance to the leaf rust agent Hemileia vastatrix were selected. Fruit yield of selected plants was calculated and seeds were characterized according to type (flat, peaberry and elephant, outturn and grain size. A total of 11 optimal F3 progenies were identified as rust resistant. By further classifications, 39 plants out from these progenies were selected, along with 15 plants from other 25 evaluated progenies. Laboratory analyses lead to a final selection of 18 coffee trees, all exhibiting leaf rust resistance, high yield and low height. Also, F4 progenies of selected plants had been evaluated regarding height and leaf rust resistance, at seedling stage, in greenhouse conditions. Eighteen plants were selected for further analysis and move forward from F3 to F4 generation in the coffee breeding program developed by IAC.

  5. Sudetic larch in Germany - Results of provenance and progeny research

    Energy Technology Data Exchange (ETDEWEB)

    Weisgerber, H. [Forest Centre for Management Planning, Research and Ecology, Hann Muenden (Germany)

    1995-12-31

    There are only a few older sources of Sudetic larch in Germany. They distinguish themselves by outstanding growth and low susceptibility to canker. This impression was confirmed by results of provenance research. The Sudetic larch tested in comparison with numerous other provenances proved to be fast-growing, site-tolerant, to a large extent insusceptible to canker, with straight but also slightly to moderately curved stems. The Sudetic provenances behave remarkably uniformly as regards these characteristics. In addition to provenance research investigations have been going on for a long time in Germany into individual differences within the Sudetic larch populations. A report is given on the results of progeny tests from free and controlled pollination, using the example of a seed orchard consisting of 54 clones. We point also to possibilities for improving stem quality by selection steps. The results of provenance and progeny research on Sudetic larch are in the meantime being put to use to a large extent in practical forestry. The forest administrations of various federal lands recommend the use of reproductive material of Sudetic origin and from seed orchards. 20 refs, 3 figs

  6. Sudetic larch in Germany - Results of provenance and progeny research

    Energy Technology Data Exchange (ETDEWEB)

    Weisgerber, H [Forest Centre for Management Planning, Research and Ecology, Hann Muenden (Germany)

    1996-12-31

    There are only a few older sources of Sudetic larch in Germany. They distinguish themselves by outstanding growth and low susceptibility to canker. This impression was confirmed by results of provenance research. The Sudetic larch tested in comparison with numerous other provenances proved to be fast-growing, site-tolerant, to a large extent insusceptible to canker, with straight but also slightly to moderately curved stems. The Sudetic provenances behave remarkably uniformly as regards these characteristics. In addition to provenance research investigations have been going on for a long time in Germany into individual differences within the Sudetic larch populations. A report is given on the results of progeny tests from free and controlled pollination, using the example of a seed orchard consisting of 54 clones. We point also to possibilities for improving stem quality by selection steps. The results of provenance and progeny research on Sudetic larch are in the meantime being put to use to a large extent in practical forestry. The forest administrations of various federal lands recommend the use of reproductive material of Sudetic origin and from seed orchards. 20 refs, 3 figs

  7. Field Investigation of the Surface-deposited Radon Progeny as a Possible Predictor of the Airborne Radon Progeny Dose Rate

    Science.gov (United States)

    Sun, Kainan; Steck, Daniel J.; Field, R. William

    2009-01-01

    The quantitative relationships between radon gas concentration, the surface-deposited activities of various radon progeny, the airborne radon progeny dose rate, and various residential environmental factors were investigated through actual field measurements in 38 selected Iowa houses occupied by either smokers or nonsmokers. Airborne dose rate was calculated from unattached and attached potential alpha energy concentrations (PAECs) using two dosimetric models with different activity-size weighting factors. These models are labeled Pdose and Jdose, respectively. Surface-deposited 218Po and 214Po were found significantly correlated to radon, unattached PAEC, and both airborne dose rates (p fireplace, or usage of a ceiling fan significantly, or marginal significantly, reduced the Pdose to 0.65 (90% CI 0.42–0.996), 0.54 (90% CI 0.28–1.02) and 0.66 (90% CI 0.45–0.96), respectively. For Jdose, only the usage of a ceiling fan significantly reduced the dose rate to 0.57 (90% CI 0.39–0.85). In smoking environments, deposited 218Po was a significant negative predictor for Pdose (RR 0.68, 90% CI 0.55–0.84) after adjusting for long-term 222Rn and environmental factors. A significant decrease of 0.72 (90% CI 0.64–0.83) in the mean Pdose was noted, after adjusting for the radon and radon progeny effects and other environmental factors, for every 10 increasing cigarettes smoked in the room. A significant increase of 1.71 in the mean Pdose was found for large room size relative to small room size (90% CI 1.08–2.79) after adjusting for the radon and radon progeny effects as well as other environmental factors. Fireplace usage was found to significantly increase the mean Pdose to 1.71 (90% CI 1.20–2.45) after adjusting for other factors. PMID:19590273

  8. Kerathocyst odontogenic tumor: Importance of selection the best treatment modality and a periodical follow-up to prevent from recurrence: A case report and literature review

    Directory of Open Access Journals (Sweden)

    Nasim Jafaripozve

    2013-01-01

    Full Text Available The keratocystic odontogenic tumor (KCOT is a relatively common oral and maxillofacial lesion with specific characteristics such us rapid growth, extension into the surrounding tissues and high rates of recurrence. Various treatment modalities have been reported. Due to the very thin and friable lining characteristic of the tumor, enucleation can be difficult undertaken and for this reason it is associated with the highest recurrence rates. A 22-year-old male referred to our clinic due to a slight expansion in the right mandible from 2 years ago. He has a history of occurrence of KCOT in this region that was treated surgically by enucleation and curettage 5 years ago. Cone beam computed tomography showed a multilocular radiolucent lesion that extended from the angle of the mandible to the symphysis. Incisional biopsy showed a KCOT recurrence that surgically treated with resection of the right mandible by continuity preservation. Selection of the best treatment modality and also a periodical lifelong follow-up is very important to reduce the rate of recurrence and morbidity of the patient.

  9. Contribution of progenies segregating for macromutations to the micromutations in lentil (Lens culinaris Medik.)

    International Nuclear Information System (INIS)

    Solanki, I.S.; Sharma, B.

    2001-01-01

    Healthy seeds of a macrosperma lentil cv Precoz Selection were treated with three doses each of ethylene imine (EI), N-nitroso-N-ethyl urea (NEU) and gamma rays. The M1 material in each treatment was classified into four groups of mutagenic damage. On the basis of macromutations induced in M2 generation, different progenies were classified into two broad groups, i.e. macromutational and non-macromutational. The latter group was again classified into selected and unselected groups on the basis of inter- and intra-family selection in M2. M3 consisted of three distinct plant populations, viz., macromutational, selected and unselected. With regard to CV, different M3 populations were observed in the order: macromutational unselected selected. NEU induced the highest amount of polygenic variability for different characters in various populations, followed by EI and gamma rays. The highest frequency of promising progenies was obtained in the selected population, followed by macromutational and unselected populations. The contribution of selected population to the total M3 promising progenies was the highest, followed by unselected and macromutational populations. Among mutagens, NEU and, between damage groups, HH (high seedling damage and high sterility) contributed maximum to total M3 promising selections [it

  10. Direct progeny detection techniques and random epidemiology

    International Nuclear Information System (INIS)

    Mayya, Y.S.; Mishra, Rosaline; Sapra, B.K.

    2015-01-01

    Over the past 40 years, there has been considerable progress in the measurements methods and their application to the estimates of risks due to radon among general populations. The previous decade saw major development in this regard. It was the direct estimate of indoor radon risk from epidemiological studies in Europe and North America. These were important findings that demonstrated the presence of lung cancer risks at residential radon levels supplementing the generally used risks estimates at high exposures obtained from uranium miner's data. The residential radon epidemiological studies largely used radon concentration as a measure of exposure. The exposure to decay products, which are primarily the dose givers, are assumed to be proportional to the measured gas concentrations. Also, the presence of thoron was neglected in these studies. Although several corrections have appeared to these assessments, the question of variability of actual decay product exposures has largely remained unaddressed. In order to circumvent this limitation, passive techniques were developed to estimate the decay product concentrations directly using deposition monitors. These are based on detecting the alpha particles from decay products deposited on an absorber mounted LR-115 detectors. Known as Direct radon, and Thoron Progeny sensors (DRPS/DTPS), these have been further refined to separate fine fraction from the coarse fraction by wire-mesh capping techniques. Large number environmental calibration exercises and field data generation has been carried out on the progeny concentrations in Indian and some European environments. The development of progeny sensors offers a new tool for future epidemiology. Since in the Indian context, there exist no radon related epidemiological estimates of risk, it is time one conducts large scale studies to seek possible correlations between DRPS/DTPS data and lung cancer risks. While epidemiological studies in High background radiation areas

  11. Eleven-Year Retrospective Report of Super-Selective Venous Sampling for the Evaluation of Recurrent or Persistent Hyperparathyroidism in 32 Patients.

    Science.gov (United States)

    Habibollahi, Peiman; Shin, Benjamin; Shamchi, Sara P; Wachtel, Heather; Fraker, Douglas L; Trerotola, Scott O

    2018-01-01

    Parathyroid venous sampling (PAVS) is usually reserved for patients with persistent or recurrent hyperparathyroidism after parathyroidectomy with inconclusive noninvasive imaging studies. A retrospective study was performed to evaluate the diagnostic efficacy of super-selective PAVS (SSVS) in patients needing revision neck surgery with inconclusive imaging. Patients undergoing PAVS between 2005 and 2016 due to persistent or recurrent hyperparathyroidism following surgery were reviewed. PAVS was performed in all patients using super-selective technique. Single-value measurements within central neck veins performed as part of super-selective PAVS were used to simulate selective venous sampling (SVS) and allow for comparison to data, which might be obtained in a non-super-selective approach. 32 patients (mean age 51 ± 15 years; 8 men and 24 women) met inclusion and exclusion criteria. The sensitivity and positive predictive value (PPV) of SSVS for localizing the source of elevated PTH to a limited area in the neck or chest was 96 and 84%, respectively. Simulated SVS, on the other hand, had a sensitivity of 28% and a PPV of 89% based on the predefined gold standard. SSVS had a significantly higher sensitivity compared to simulated SVS (p localizing the source of hyperparathyroidism in patients undergoing revision surgery for hyperparathyroidism in whom noninvasive imaging studies are inconclusive. SSVS data had also markedly higher sensitivity for localizing disease in these patients compared to simulated SVS.

  12. Initial Steps to inform selection of continuation cognitive therapy or fluoxetine for higher risk responders to cognitive therapy for recurrent major depressive disorder.

    Science.gov (United States)

    Vittengl, Jeffrey R; Anna Clark, Lee; Thase, Michael E; Jarrett, Robin B

    2017-07-01

    Responders to acute-phase cognitive therapy (A-CT) for major depressive disorder (MDD) often relapse or recur, but continuation-phase cognitive therapy (C-CT) or fluoxetine reduces risks for some patients. We tested composite moderators of C-CT versus fluoxetine's preventive effects to inform continuation treatment selection. Responders to A-CT for MDD judged to be at higher risk for relapse due to unstable or partial remission (N=172) were randomized to 8 months of C-CT or fluoxetine with clinical management and assessed, free from protocol treatment, for 24 additional months. Pre-continuation-treatment characteristics that in survival analyses moderated treatments' effects on relapse over 8 months of continuation-phase treatment (residual symptoms and negative temperament) and on relapse/recurrence over the full observation period's 32 months (residual symptoms and age) were combined to estimate the potential advantage of C-CT versus fluoxetine for individual patients. Assigning patients to optimal continuation treatment (i.e., to C-CT or fluoxetine, depending on patients' pre-continuation-treatment characteristics) resulted in absolute reduction of relapse or recurrence risk by 16-21% compared to the other non-optimal treatment. Although these novel results require replication before clinical application, selecting optimal continuation treatment (i.e., personalizing treatment) for higher risk A-CT responders may decrease risks of MDD relapse and recurrence substantively. Copyright © 2017 Elsevier Ireland Ltd. All rights reserved.

  13. Recurrent varicocele

    Directory of Open Access Journals (Sweden)

    Katherine Rotker

    2016-01-01

    Full Text Available Varicocele recurrence is one of the most common complications associated with varicocele repair. A systematic review was performed to evaluate varicocele recurrence rates, anatomic causes of recurrence, and methods of management of recurrent varicoceles. The PubMed database was evaluated using keywords "recurrent" and "varicocele" as well as MESH criteria "recurrent" and "varicocele." Articles were not included that were not in English, represented single case reports, focused solely on subclinical varicocele, or focused solely on a pediatric population (age <18. Rates of recurrence vary with the technique of varicocele repair from 0% to 35%. Anatomy of recurrence can be defined by venography. Management of varicocele recurrence can be surgical or via embolization.

  14. Variability and performance evaluation of introgressed Nigerian dura x Deli dura oil palm progenies.

    Science.gov (United States)

    Noh, A; Rafii, M Y; Mohd Din, A; Kushairi, A; Norziha, A; Rajanaidu, N; Latif, M A; Malek, M A

    2014-04-03

    Twelve introgressed oil palm (Elaeis guineensis) progenies of Nigerian dura x Deli dura were evaluated for bunch yield, yield attributes, bunch quality components and vegetative characters at the Malaysian Palm Oil Board Research Station, in Keratong, Pahang, Malaysia. Analysis of variance revealed significant to highly significant genotypic differences, indicating sufficient genetic variability among the progenies for bunch yield and its attributes, vegetative characters and bunch quality components, except fruit to bunch ratio. Fresh fruit bunch yield ranged from 167 kg·palm(-1)·year(-1) in PK1330 to 212 kg·palm(-1)·year(-1) in PK1351, with a mean yield of 192 kg·palm(-1)·year(-1). Among the progeny, PK1313 had the highest oil to bunch ratio (19.36%), due to its high mesocarp to fruit ratio, fruit to bunch ratio and low shell to fruit ratio. Among the progenies, PK1313 produced the highest oil yield of 31.4 kg·palm(-1)·year(-1), due to a high mesocarp to fruit ratio (61.2%) and a low shell to fruit ratio (30.7%), coupled with high fruit to bunch ratio (65.6%). PK1330 was found promising for selection, as it had desirable vegetative characters, including smaller petiole cross section (27.15 cm2), short rachis length (4.83 m), short palm height (1.85 m), and the lowest leaf number (164.6), as these vegetative characters are prerequisites for selecting palms for high density planting and high yield per hectare. The genetic variability among the progenies was found to be high, indicating ample scope for further breeding, followed by selection.

  15. Autumn frost hardiness in Norway spruce plus tree progeny and trees of the local and transferred provenances in central Sweden.

    Science.gov (United States)

    Hannerz, Mats; Westin, Johan

    2005-09-01

    Reforestation with provenances from locations remote from the planting site (transferred provenances) or the progeny of trees of local provenances selected for superior form and vigor (plus trees) offer alternative means to increase yield over that obtained by the use of seed from unselected trees of the local provenance. Under Swedish conditions, Norway spruce (Picea abies (L.) Karst.) of certain transferred provenances generally has an advantage in productivity relative to the local provenance comparable to that of progeny of plus trees. The aim of this study was to explore the extent to which productivity gains achieved by provenance transfer or the use of plus tree progeny are associated with reductions in autumn frost hardiness, relative to that of trees of the local provenance. In a field trial with 19-year-old trees in central Sweden, bud hardiness was tested on four occasions during the autumn of 2002. Trees of the local provenance were compared with trees of a south Swedish provenance originating 3 degrees of latitude to the south, a Belarusian provenance and the progeny of plus trees of local origin. The Belarusian provenance was the least hardy and the local provenance the most hardy, with plus tree progeny and the south Swedish provenance being intermediate in hardiness. Both the Belarusian provenance and the plus tree progeny were significantly taller than trees of the other populations. Within provenances, tree height was negatively correlated with autumn frost hardiness. Among the plus tree progeny, however, no such correlation between tree height and autumn frost hardiness was found. It is concluded that although the gain in productivity achieved by provenance transfer from Belarus was comparable to that achieved by using the progeny of plus trees of the local provenance, the use of trees of the Belarus provenance involved an increased risk of autumn frost damage because of later hardening.

  16. Patterns of recurrence after selective postoperative radiation therapy for patients with head and neck squamous cell carcinoma

    International Nuclear Information System (INIS)

    Murakami, Naoya; Matsumoto, Fumihiko; Yoshimoto, Seiichi; Ito, Yoshinori; Mori, Taisuke; Ueno, Takao; Tuchida, Keisuke; Kashihara, Tairo; Kobayashi, Kazuma; Harada, Ken; Kitaguchi, Mayuka; Sekii, Shuhei; Umezawa, Rei; Takahashi, Kana; Inaba, Koji; Igaki, Hiroshi; Itami, Jun

    2016-01-01

    The radiation field for patients with postoperative head and neck squamous cell carcinoma is narrower in our institution than in Western countries to reduce late radiation related toxicities. This strategy is at a risk of loco-regional or distant metastasis. However, because patients are more closely checked than in Western countries by every 1 to 2 months intervals and it is supposed that regional recurrences are identified and salvage surgeries are performed more quickly. Therefore, it is considered that patient survival would not be compromised with this strategy. The aim of this study was to investigate the feasibility of this strategy retrospectively. Patients who underwent neck dissection with close or positive margin, extra-capsular spread (ECS), multiple regional lymph node metastasis, pT4, with or without primary tumor resection were treated with postoperative radiation therapy. The volume of radiation field, especially the coverage of prophylactic regional lymph node area, was discussed among head and neck surgeons and radiation oncologists taking into account the clinical factors including patient’s age, performance status, number of positive lymph nodes, size of metastatic lymph nodes, extension of primary tumor beyond the midline, and existence of ECS. Seventy-two patients were identified who were treated with postoperative radiation therapy for head and neck squamous cell carcinoma between November 2005 and December 2014. There were 20 patients with oropharynx, 19 with hypopharynx, 7 with larynx, 23 with oral cavity, and 3 with other sites. Thirty eight patients had their neck irradiated bilaterally and 34 unilaterally. Median follow-up period for patients without relapse was 20.7 months (5.1–100.7). Thirty two patients had disease relapse after treatment including 22 loco-regional recurrence and 14 distant metastases. Among 22 loco-regional recurrence, seven patients underwent salvage surgery and one of them was no relapse at the time of the

  17. FOLIAR NUTRIENT CONTENTS AND FRUIT YIELD IN CUSTARD APPLE PROGENIES

    Directory of Open Access Journals (Sweden)

    Paulo Sérgio Lima e Silva

    2009-01-01

    Full Text Available Foliar nutrient contents are evaluated in several fruit trees with many objectives. Leaf analysis constitutes a way of evaluating the nutritional requirements of crops. Due to the positive impact that fertilizers have on crop yields, researchers frequently try to evaluate the correlations between yield and foliar nutrient contents. This work's objective was to present fruit yields from the 4th to the 6th cropping seasons, evaluate foliar nutrient contents (on the 5th cropping season, and estimate the correlations between these two groups of traits for 20 half-sibling custard apple tree progenies. The progenies were evaluated in a random block design with five replicates and four plants per plot. One hundred leaves were collected from the middle third of the canopy (in height of each of four plants in each plot. The leaves were collected haphazardly, i.e., in a random manner, but without using a drawing mechanism. In the analysis of variance, the nutrient concentrations in the leaves from plants of each plot were represented by the average of four plants in the plot. Fruit yield in the various progenies did not depend on cropping season; progeny A4 was the most productive. No Spearman correlation was found between leaf nutrient concentrations and fruit yield. Increased nutrient concentrations in the leaves were progeny-dependent, i.e., with regard to Na (progenies FE5 and JG1, Ca (progeny A4, Mg (progeny SM7, N (progeny A3, P (progeny M, and K contents (progeny JG3. Spearman's correlation was negative between Na-Mg, Na-Ca, and Mg-P contents, and positive between Mg-Ca and N-K contents.

  18. [Selective biopsy of the sentinel lymph node in breast cancer: without axillary recurrences after a mean follow-up of 4.5 years].

    Science.gov (United States)

    Bañuelos Andrío, Luis; Rodríguez Caravaca, Gil; Argüelles Pintos, Miguel; Mitjavilla Casanova, Mercedes

    2014-01-01

    To analyze the rate of axillary recurrences (AR) in patients with early breast cancer who had not undergone an axillary node dissection (ALND) because of a negative sentinel lymph node biopsy (SLNB). The study includes 173 patients operated on for breast cancer and selective node biopsy. In 32 patients the SLNB was positive and undergone subsequent ALND. We followed up 141 patients with negative SLNB without LDN, with a median follow up of 55 months (range 74-36). The detection rate of SLN was of 99.42%. After a median follow-up of 4.5 years, there were no axillary recurrences. Two patients developed local recurrence, other two patients developed distant metastases and four patients developed a metachronous tumor. Four patients died, none of them because of breast cancer. The results obtained support the SLNB as an accurate technique in the axillary stratification of patients with breast cancer, offering in the cases of negative SLNB a safe axillary control after 4.5 year follow-up. Copyright © 2013 Elsevier España, S.L.U. and SEMNIM. All rights reserved.

  19. Impact of target area selection in 125 Iodine seed brachytherapy on locoregional recurrence in patients with non-small cell lung cancer.

    Science.gov (United States)

    Yan, Wei-Liang; Lv, Jin-Shuang; Guan, Zhi-Yu; Wang, Li-Yang; Yang, Jing-Kui; Liang, Ji-Xiang

    2017-05-01

    Computed tomography (CT)-guided percutaneous implantation of 125 Iodine radioactive seeds requires the precise arrangement of seeds by tumor shape. We tested whether selecting target areas, including subclinical areas around tumors, can influence locoregional recurrence in patients with non-small cell lung cancer (NSCLC). We divided 82 patients with NSCLC into two groups. Target areas in group 1 (n = 40) were defined along tumor margins based on lung-window CT. Target areas in group 2 (n = 42) were extended by 0.5 cm in all dimensions outside tumor margins. Preoperative plans for both groups were based on a treatment plan system, which guided 125 I seed implantation. Six months later, patients underwent chest CT to evaluate treatment efficacy (per Response Evaluation Criteria in Solid Tumors version 1). We compared locoregional recurrences between the groups after a year of follow-up. We then used the treatment plan system to extend target areas for group 1 patients by 0.5 cm (defined as group 3 data) and compared these hypothetical group 3 planned seeds with the actual seed numbers used in group 1 patients. All patients successfully underwent implantation; none died during the follow-up period. Recurrence was significantly lower in group 2 than in group 1 ( P  area for 125 I seeds can decrease recurrence risk by eradicating cancerous lymph-duct blockades within the extended areas. © 2017 The Authors. Thoracic Cancer published by China Lung Oncology Group and John Wiley & Sons Australia, Ltd.

  20. Genetic parameters on Bali cattle progeny test population

    Science.gov (United States)

    Hariansyah, A. R.; Raharjo, A.; Zainuri, A.; Parwoto, Y.; Prasetiyo, D.; Prastowo, S.; Widyas, N.

    2018-03-01

    Bali cattle (Bos javanicus) is Indonesian indigenous cattle with having superior genetics potential on fitness traits in tropical environment and low feed quality. Bali Cattle Breeding Center Pulukan Indonesia conducted progeny test per annum in order to select bulls using offspring’s phenotype. This paper aimed to estimate the genetic parameters of yearling weight in Bali cattle progeny test populations and to observe the variation between periods in the above breeding center. Data were collected from the year of 2013 to 2014. There were four bulls (3 tests, 1 AI control) in 2013 and five bulls (4 tests, 1 AI) in 2014. Thirty breeding females were allocated per paddock per bull and allowed to mate naturally. In total 80 and 104 offspring’s records were obtained from 2013 and 2014 data, respectively. We built half-sib family model to estimate the additive genetic variance due to the sire and later estimate the breeding value (EBV) of each sire. Results showed that in 2013 the heritability (h2) for yearling weight was 0.19 while in 2014 was 0.79. In both years, tested bulls had higher EBV compared to the control bulls. The remarkable difference of heritability between years was due to the variations among bull candidates which might differ every year with regards to their origins. The fact that the EBV of tested bulls were higher than the control bulls gave us insight that despite the conservation policy and the continuous departure of Bali cattle bulls outside the Island, the population could still maintain its genetic quality.

  1. Determination of radon and progeny concentrations in Brazilian underground mines

    International Nuclear Information System (INIS)

    Fraenkel, Mario O.; Gouvea, Vandir de Azevedo; Macacini, Jose F.; Cardozo, Katia; Carvalho Filho, Carlos A. de; Lima, Carlos E.

    2008-01-01

    The aim of this work is to present the activities related to the determination of radon and progeny concentrations in underground mines in Brazil. Radon is originated from decay of radium-226 and radium-228 present in rocks. Radon and its short-lived progeny can be retained in the workers pulmonary alveoli, and this way they bring about cancer risk to these mining professionals. The occurrence of high radon concentrations in underground coal and copper mines and the lack of systematic survey motivated CNEN, the regulatory agency, to develop the Radon Project, aiming to aid the formulation of a specific regulation with occupational dose limits consistent with international standards recommended by the International Atomic Energy Agency (IAEA). Dozens of underground mines are currently in operation in the national. It had to be noted that about 50% of these mines are located in Minas Gerais province, and for this reason it was chosen to start the Project. In each underground mine it is installed in selected points passive nuclear track etch radon detectors, type LEXAN and Cr-39, for periods from three to five months. It was also made local measurements with Dose Man Pro detectors from SARAD. The points are chosen according to geological features, radiometric activity and characteristics of prospect development. The determination of radon present in mines has been made in IEN (Nuclear Engineering Institute)/Rio de Janeiro-RJ, LAPOC (Pocos de Caldas Laboratory)/Pocos de Caldas-MG e ESPOA (Porto Alegre Office)/Porto Alegre-RS. Until now it was visited about 35 mines in a universe of about 50 mines, from which 20% showed concentration values higher than international limits (ICRP 65), between 500 and 1500 Bq.m -3 . (author)

  2. Parental partners effects on progenies characteristics on hybridization within the Larix genus

    Energy Technology Data Exchange (ETDEWEB)

    Sindelar, J.; Frydl, J. [Forestry and Game Management Research Inst., Jiloviste (Czech Republic)

    1995-12-31

    Larch progenies of maternal clone No. 52-4-11 (Larix decidua Mill.) combined with the series of paternal clones of the same species and further of the Larix leptolepis Gord. and L. gmelini (Rupr.) Ledeb. species were evaluated on three research plots with larch (Larix sp.). Growth in height and thickness as well as stem forming were monitored at the age of 11 and 22 years. There was found out a significant share of variance falling on the action of mother, hence the existence of extra-nuclear heredity can be anticipated, particularly in interspecific hybrids. Comparing with the control in interspecific hybrids mostly luxuriant growth is displayed. On one of the studied plots there was found out the assumed growth depression in the quantitative characters of progenies originated from self-pollination. Some results of the research can be used as an auxiliary criterion in the selection of progenies and trees within the progenies for the establishment of seed orchards to produce hybrid seed of F2 generation. 24 refs, 6 figs, 6 tabs

  3. Parental partners effects on progenies characteristics on hybridization within the Larix genus

    Energy Technology Data Exchange (ETDEWEB)

    Sindelar, J; Frydl, J [Forestry and Game Management Research Inst., Jiloviste (Czech Republic)

    1996-12-31

    Larch progenies of maternal clone No. 52-4-11 (Larix decidua Mill.) combined with the series of paternal clones of the same species and further of the Larix leptolepis Gord. and L. gmelini (Rupr.) Ledeb. species were evaluated on three research plots with larch (Larix sp.). Growth in height and thickness as well as stem forming were monitored at the age of 11 and 22 years. There was found out a significant share of variance falling on the action of mother, hence the existence of extra-nuclear heredity can be anticipated, particularly in interspecific hybrids. Comparing with the control in interspecific hybrids mostly luxuriant growth is displayed. On one of the studied plots there was found out the assumed growth depression in the quantitative characters of progenies originated from self-pollination. Some results of the research can be used as an auxiliary criterion in the selection of progenies and trees within the progenies for the establishment of seed orchards to produce hybrid seed of F2 generation. 24 refs, 6 figs, 6 tabs

  4. Comparison of different methods for thoron progeny measurement

    International Nuclear Information System (INIS)

    Bi Lei; Zhu Li; Shang Bing; Cui Hongxing; Zhang Qingzhao

    2009-01-01

    Four popular methods for thoron progeny measurement were discussed, including the aspects of detector,principle, precondition, calculation advantages and disadvantages. Comparison experiments were made in mine and houses with high background in Yunnan Province. Since indoor thoron progeny changes with time obviously and with no rule, α track method is recommended in the area of radiation protection for environmental detection and assessment. (authors)

  5. Genetic selection Pinus greggii progeny to the establishment of seed orchards Seleção genética de progênies de Pinus greggii para formação de pomares de sementes

    Directory of Open Access Journals (Sweden)

    Ananda Virgínia de Aguiar

    2010-10-01

    Full Text Available The main deterrent to the adoption of new species for operational plantations is the availability of  genetically improved seeds in sufficient amount to supply the  market. Therefore, this study was carried out with the objective to estimate genetic parameters for individual selection as a basis to transform the field trial into a seedling seed orchard. The trial contained forty seven half-sib families from five Mexican provenances, including northern and central Mexico sources. These were planted at Ponta Grossa, Paraná State, Brazil, in a
    randomized complete block design with nine  replications of five-tree linear plots in a 3 m x 3 m spacing. Height, dbh (diameter at breast height and stem form were assessed in thirteen-year old tree. Variance components were estimated by using SELEGEN-REML/BLUP software. Other procedures included prediction of breeding values and deviance analyses. The significant genetic variation among provenances as well as among and within families in all traits confirmed their high value. The southern Mexico sources showed the highest productivity. The expected progress in  improvement through just one cycle of selection was estimated in 21.6 % in wood volume.

    doi: 10.4336/2010.pfb.30.62.107
    Um dos principais impedimentos para a adoção de novas espécies para as plantações comerciais é a

    escassez de sementes geneticamente melhoradas, em quantidade suficiente para abastecer o mercado. Portanto,

    o objetivo deste estudo foi estimar parâmetros genéticos que possibilitem a realização de seleção individual em

    um teste combinado de procedências e progênies de P. greggii como base para transformar a área num pomar

    de sementes por mudas. No presente trabalho, foram avaliadas cinco procedências e quarenta e sete progênies

    de P. greggii da região norte e central do México. O experimento foi instalado

  6. The behavior of maize hybrids generated from contrasting progenies regarding the use of nitrogen

    Directory of Open Access Journals (Sweden)

    Fernando Lisboa Guedes

    2014-11-01

    Full Text Available The purpose of this study was to evaluate the performance of maize hybrids synthesized from contrasting genotypes with regard to the use of nitrogen that were selected for their performance in topcrosses. Sixty-seven S0:1 progenies derived from the germplasm bank of Ufla were evaluated in topcross combinations with two testers  at two nitrogen levels. The six progenies with the greatest tolerance and responsiveness to nitrogen (RT and the five with the least tolerance and responsiveness (RnTn were selected and, were, afterwards, crossed in a complete diallel, for a total of 55 hybrid combinations. The following genetic parameters were estimated: genetic variance among the hybrids (σ^2G, broad sense heritability in the mean of the hybrids, and selective accuracy (r^2gg. It was observed that the genetic parameters were greater in the environments with available nitrogen and that the early selection by performance in topcrosses of progenies tolerant to low N levels may not be made with high intensity. The hybrids tolerant to low N levels were obtained by crossing contrasting parents.

  7. Persistent and recurrent hyperparathyroidism.

    Science.gov (United States)

    Guerin, Carole; Paladino, Nunzia Cinzia; Lowery, Aoife; Castinetti, Fréderic; Taieb, David; Sebag, Fréderic

    2017-06-01

    Despite remarkable progress in imaging modalities and surgical management, persistence or recurrence of primary hyperparathyroidism (PHPT) still occurs in 2.5-5% of cases of PHPT. The aim of this review is to expose the management of persistent and recurrent hyperparathyroidism. A literature search was performed on MEDLINE using the search terms "recurrent" or "persistent" and "hyperparathyroidism" within the past 10 years. We also searched the reference lists of articles identified by this search strategy and selected those we judged relevant. Before considering reoperation, the surgeon must confirm the diagnosis of PHPT. Then, the patient must be evaluated with new imaging modalities. A single adenoma is found in 68% of cases, multiglandular disease in 28%, and parathyroid carcinoma in 3%. Others causes (<1%) include parathyromatosis and graft recurrence. The surgeon must balance the benefits against the risks of a reoperation (permanent hypocalcemia and recurrent laryngeal nerve palsy). If surgery is necessary, a focused approach can be considered in cases of significant imaging foci, but in the case of multiglandular disease, a bilateral neck exploration could be necessary. Patients with multiple endocrine neoplasia syndromes are at high risk of recurrence and should be managed regarding their hereditary pathology. The cure rate of persistent-PHPT or recurrent-PHPT in expert centers is estimated from 93 to 97%. After confirming the diagnosis of PHPT, patients with persistent-PHPT and recurrent-PHPT should be managed in an expert center with all dedicated competencies.

  8. Radon: Chemical and physical states of radon progeny. Final technical report

    International Nuclear Information System (INIS)

    Castleman, A.W. Jr.

    1996-01-01

    The evolving chemical and physical form of radon progeny influence their transport to the bioreceptor and the extent to which that receptor can take up these species into various tissues. When first born following radioactive decay processes, the potentially deleterious radon progeny undergo various physical and chemical transformations as they transcend from a highly charged to a neutral state, and interact with various constituents of the environment. These transformations impact on the extent to which the radon progeny become associated with aerosol particles on the one hand, and their ultimate chemical form that is available for uptake in the biosystem, on the other. The program, which originally commenced in 1987, dealt with the basic chemistry and physics of radon progeny and hence impacted on several themes of importance to the DOE/OHER radon program. One of these is dose response, which is governed by the physical forms of the radon progeny, their transport to the bioreceptor and the chemical forms that govern their uptake. The second theme had to do with cellular responses, one of the major issues motivating the work. It is well known that various sizes of ions and molecules are selectively transported across cell membrane to differing degrees. This ultimately has to do with their chemical and physical forms, charge and size. The overall objective of the work was threefold: (1) quantifying the mechanisms and rates of the chemical and physical transformation; (2) ascertaining the ultimate chemical forms, and (3) determining the potential interactions of these chemical species with biological functional groups to ascertain their ultimate transport and incorporation within cells

  9. Feeding broiler breeder males. 4. Deficient feed allocation reduces fertility and broiler progeny body weight.

    Science.gov (United States)

    Romero-Sanchez, H; Plumstead, P W; Leksrisompong, N; Brannan, K E; Brake, J

    2008-04-01

    Two experiments were conducted to evaluate the effects of male broiler breeder feed intake on broiler progeny performance. In experiment 1, a low cumulative nutrition program supplied 29,580 kcal of ME and 1,470 g of CP, whereas a high cumulative nutrition program supplied 33,500 kcal of ME and 1,730 g of CP to photostimulation at 21 wk of age. Two diets (HiDiet and LoDiet) were formulated, and a single feeding program was used to achieve the selected nutrient intakes. The HiDiet group of males in experiment 1 achieved greater BW and exhibited lower fertility when fed as the LoDiet males from the onset of egg production. The HiDiet breeder males subsequently produced male broilers from eggs laid at 29 wk of age that exhibited lower BW at 42 d. This was due to the heaviest 50% of the breeder males in this treatment not gaining BW consistently due to less-than-adequate ME intake relative to their greater BW requirements. Two feeding programs during the production period (constant or increasing) were compared in experiment 2. Broilers were hatched from eggs laid at 32 and 48 wk of age to evaluate the vertical effect of male treatments on progeny performance. No difference in fertility or broiler performance was found at 32 wk. However, the constant feeding program produced lower fertility from 36 to 55 wk of age, and this resulted in a lower male and female broiler progeny BW at 42 d of age from eggs collected at 48 wk of age. Adequate breeder male feed allocation during the production period improved fertility and favorably affected broiler progeny performance in both experiments. However, broiler progeny effects were observed only when there were differences in fertility, which suggests that the males with the greatest genetic potential were not mating at these times.

  10. Indoor thoron and radon progeny measurements

    International Nuclear Information System (INIS)

    Tu, K.W.; George, A.C.; Lowder, W.M.; Gogolak, C.V.

    1992-01-01

    Measurements of indoor thoron ( 220 Rn) and radon ( 222 Rn) progeny activities were conducted in 40 homes and six public buildings in five states. A commercial alpha spectrometer system and four portable alpha integrating sampling monitors using diffused junction silicon detectors were used for sampling and recording of radionuclide data in particular the potential alpha energy concentrations (PAEC). The data were analysed for the ratios of PAEC- 220 Rn to PAEC- 222 Rn, and the correlations between the two quantities, and their estimated annual effective dose equivalent (AEDE). The results show that the PAEC ratios were 0.09, 0.6, 0.55, and 0.47, respectively, for all homes with the PAEC- 222 Rn > 400, between 100 and 400, -3 , and the total of all homes tested; the AEDE ratios were 0.03, 0.21, 0.19 and 0.16, respectively. No strong correlations were found between PAEC- 220 Rn and PAEC- 222 Rn, and between basement and ground floor data for PAEC- 220 Rn, but the PAEC- 222 Rn data showed a strong correlation between the basement and the ground floor values. Simultaneous measurements of PAEC- 220 Rn and PAEC- 222 Rn on the ground floor and in the basement of each of the 23 single-family houses tested suggests that 220 Rn entry from building materials may be as significant as from the underlying soil. (author)

  11. Selective arterial embolization for control of haematuria secondary to advanced or recurrent transitional cell carcinoma of the bladder.

    LENUS (Irish Health Repository)

    Halpenny, D

    2014-05-02

    Haematuria is a common symptom in patients with advanced transitional cell carcinoma of the bladder. We report our experience of selective pelvic embolization using gelfoam as an embolic agent to treat intractable haematuria in these patients.

  12. A phase 2 study of the first imipridone ONC201, a selective DRD2 antagonist for oncology, administered every three weeks in recurrent glioblastoma.

    Science.gov (United States)

    Arrillaga-Romany, Isabel; Chi, Andrew S; Allen, Joshua E; Oster, Wolfgang; Wen, Patrick Y; Batchelor, Tracy T

    2017-10-03

    ONC201 is an oral, small molecule selective antagonist of the G protein-coupled receptor DRD2 that causes p53-independent apoptosis in tumor cells via integrated stress response activation and Akt/ERK inactivation. We performed a Phase II study that enrolled 17 patients with recurrent, bevacizumab-naïve, IDH1/2 WT glioblastoma who received 625mg ONC201 every three weeks. Median OS was 41.6 weeks with OS6 of 71% and OS9 of 53%. Seven of 17 patients are alive. PFS6 was 11.8% with two patients remaining on study who continue to receive ONC201 for >12 months. One of these patients had a durable objective response with a secondary glioblastoma possessing a H3.3 K27M mutation, exhibiting regression by 85% in one lesion and 76% in the second lesion. The second patient who continues to receive ONC201 for >12 months remains disease-free after enrolling on this trial following a re-resection. No drug-related SAEs or treatment discontinuation due to toxicity occurred. Plasma PK at 2 hours post-dose was 2.6 ug/mL, serum prolactin induction was observed as a surrogate marker of target engagement, and DRD2 was expressed in all evaluated archival tumor specimens. In summary, ONC201 is well tolerated and may have single agent activity in recurrent glioblastoma patients.

  13. Recurrent Meningitis.

    Science.gov (United States)

    Rosenberg, Jon; Galen, Benjamin T

    2017-07-01

    Recurrent meningitis is a rare clinical scenario that can be self-limiting or life threatening depending on the underlying etiology. This review describes the causes, risk factors, treatment, and prognosis for recurrent meningitis. As a general overview of a broad topic, the aim of this review is to provide clinicians with a comprehensive differential diagnosis to aide in the evaluation and management of a patient with recurrent meningitis. New developments related to understanding the pathophysiology of recurrent meningitis are as scarce as studies evaluating the treatment and prevention of this rare disorder. A trial evaluating oral valacyclovir suppression after HSV-2 meningitis did not demonstrate a benefit in preventing recurrences. The data on prophylactic antibiotics after basilar skull fractures do not support their use. Intrathecal trastuzumab has shown promise in treating leptomeningeal carcinomatosis from HER-2 positive breast cancer. Monoclonal antibodies used to treat cancer and autoimmune diseases are new potential causes of drug-induced aseptic meningitis. Despite their potential for causing recurrent meningitis, the clinical entities reviewed herein are not frequently discussed together given that they are a heterogeneous collection of unrelated, rare diseases. Epidemiologic data on recurrent meningitis are lacking. The syndrome of recurrent benign lymphocytic meningitis described by Mollaret in 1944 was later found to be closely related to HSV-2 reactivation, but HSV-2 is by no means the only etiology of recurrent aseptic meningitis. While the mainstay of treatment for recurrent meningitis is supportive care, it is paramount to ensure that reversible and treatable causes have been addressed for further prevention.

  14. Genetic Gains in Yield and Yield Related Traits under Drought Stress and Favorable Environments in a Maize Population Improved Using Marker Assisted Recurrent Selection

    Directory of Open Access Journals (Sweden)

    Folusho Bankole

    2017-05-01

    Full Text Available The objective of marker assisted recurrent selection (MARS is to increase the frequency of favorable marker alleles in a population before inbred line extraction. This approach was used to improve drought tolerance and grain yield (GY in a biparental cross of two elite drought tolerant lines. The testcrosses of randomly selected 50 S1 lines from each of the three selection cycles (C0, C1, C2 of the MARS population, parental testcrosses and the cross between the two parents (F1 were evaluated under drought stress (DS and well watered (WW well as under rainfed conditions to determine genetic gains in GY and other agronomic traits. Also, the S1 lines derived from each selection types were genotyped with single nucleotide polymorphism (SNP markers. Testcrosses derived from C2 produced significantly higher grain field under DS than those derived from C0 with a relative genetic gain of 7% per cycle. Also, the testcrosses of S1 lines from C2 showed an average genetic gain of 1% per cycle under WW condition and 3% per cycle under rainfed condition. Molecular analysis revealed that the frequency of favorable marker alleles increased from 0.510 at C0 to 0.515 at C2, while the effective number of alleles (Ne per locus decreased from C0 (1.93 to C2 (1.87. Our results underscore the effectiveness of MARS for improvement of GY under DS condition.

  15. Identification of cocoa trees combining high yield potential and resistance to diseases in segregating progenies In Ecuador

    Science.gov (United States)

    Diseases and low yielding planting material are the main factors limiting production of “fine” or “flavour” cocoa in Ecuador. This makes it necessary to develop modern varieties capable of overcoming these limitations. During the 1960s and 1970s INIAP tested several progenies from selected crosses...

  16. The German thoron progeny chamber-Concept and application

    International Nuclear Information System (INIS)

    Roettger, Annette; Honig, Anja; Arnold, Dirk

    2009-01-01

    Following completion of the project 'Generation and characterisation of reference atmospheres of thoron decay products for the calibration of measuring devices for thoron decay products', the Physikalisch-Technische Bundesanstalt (PTB) now operates a thoron progeny chamber in which 220 Rn (thoron), 222 Rn and its progenies can be made available under almost all ambient conditions. This allows all measuring systems to be calibrated under realistic climatic conditions with an accuracy unique worldwide.

  17. Lung dosimetry for inhaled radon progeny

    International Nuclear Information System (INIS)

    Hofmann, W.

    1986-01-01

    Lung cancer risk assessment for inhaled radon progeny requires a detailed knowledge of the dose distribution pattern throughout the human respiratory tract. Current lung dosimetry models take into acocunt aerosol deposition in a formalized airway structrue, modification of the initial deposition pattern by clearance mechanisms, and the energy deposited by alpha particles in sensitive cells of the bronchial epithelium. The resulting dose distribution pattern depends on the characteristics of the inhaled aerosol and the breathing pattern. Special emphasis has been laid on the age dependency of the anatomical structure of the human lung and the resulting doses, as well as on the rediological significance of enhanced aerosol deposition at bronchial bifuraction. The biological variability inherent in all morphometric, physiological and histological parameters involved in lung dosimetry suggests the application of stochastic modelling techniques. Examples for the use of Monte Carlo methods presented here are the random walk of inhaled particles through a random airway geometry, and the influence of the intra-subject variability of radiation doses on radiation protection standards. At the cellular level the concept of absorbed dose loses its significance and has to be replaced by microdosimetric concepts, such as internal microdosimtry or track structure theory. An image-analysis model allows us to construct specific energy distributions in sensitive lung cells. Application of a track structure model of alpha particle interaction with bronchial epithelial cells permits the calculation of probabilities for inactivation, transformation, and tumor induction. The latter has been used to analyse lung cancer risk at low doses in Chinese high background areas

  18. X-irradiation induced changes in character association in some advance progenies of Capsularis jute

    International Nuclear Information System (INIS)

    Sinhamahapatra, S.P.; Tripathi, R.

    1992-01-01

    Changes in character association following mutagen treatments have been reported in different crops. The present finding indicated possibilities of altering the nature and degree of character association for having more efficient combination of characters through induced mutation. The direct and indirect path coefficient values of each of the characters on fibre yield or other important traits indicate new dimensions for selection in the desired directions in the character association as well as the direct and indirect effects of characters in the selected irradiated progenies. (author). 9 refs., 1 tab

  19. Attachment of radon progeny to cigarette-smoke aerosols

    International Nuclear Information System (INIS)

    Biermann, A.H.; Sawyer, S.R.

    1995-05-01

    The daughter products of radon gas are now recognized as a significant contributor to radiation exposure to the general public. It is also suspected that a synergistic effect exists with the combination cigarette smoking and radon exposure. We have conducted an experimental investigation to determine the physical nature of radon progeny interactions with cigarette smoke aerosols. The size distributions of the aerosols are characterized and attachment rates of radon progeny to cigarette-smoke aerosols are determined. Both the mainstream and sidestream portions of the smoke aerosol are investigated. Unattached radon progeny are very mobile and, in the presence of aerosols, readily attach to the particle surfaces. In this study, an aerosol chamber is used to contain the radon gas, progeny and aerosol mixture while allowing the attachment process to occur. The rate of attachment is dependent on the size distribution, or diffusion coefficient, of the radon progeny as well as the aerosol size distribution. The size distribution of the radon daughter products is monitored using a graded-screen diffusion battery. The diffusion battery also enables separation of the unattached radon progeny from those attached to the aerosol particles. Analysis of the radon decay products is accomplished using alpha spectrometry. The aerosols of interest are size fractionated with the aid of a differential mobility analyzer and cascade impactor. The measured attachment rates of progeny to the cigarette smoke are compared to those found in similar experiments using an ambient aerosol. The lowest attachment coefficients observed, ∼10 -6 cm 3 /s, occurred for the ambient aerosol. The sidestream and mainstream smoke aerosols exhibited higher attachment rates in that order. The results compared favorably with theories describing the coagulation process of aerosols

  20. Genetic variation of phytochemical compounds in progenies of Ilex paraguariensis St. Hil.

    Directory of Open Access Journals (Sweden)

    Euclides Lara Cardozo Junior

    2009-01-01

    Full Text Available Mate (Ilex paraguariensis St. Hil contains phytochemical compounds capable of preventing a number of healthproblems. Knowledge on the genetic contribution to the variability in these compounds can help to obtain mate progenies withhigher levels thereof in breeding programs. The composition of triterpene saponins, methylxanthines, chlorogenic acid andthe antioxidant activity of eight mate progenies were evaluated. Significant differences among progenies were verified incontents of triterpene saponins (0.003-0.080%, caffeine (0.226-1.377%, theobromine (0.176-0.831%, and chlorogenicacid (1.344-2.031% and in antioxidant activity (31.251-51.406%. The contents of theobromine were found to be negativelycorrelated with saponins and caffeine, and caffeine with chlorogenic acid, while theobromine was positively correlated withchlorogenic acid. The heritability values for saponins (75.09%, caffeine (75.19%, theobromine (66.87%, chlorogenic acid(52.86% and antioxidant activity (67.75% indicate the possibility of genetic gain in selection for these traits.

  1. Selection against recombinant hybrids maintains reproductive isolation in hybridizing Populus species despite F1 fertility and recurrent gene flow.

    Science.gov (United States)

    Christe, Camille; Stölting, Kai N; Bresadola, Luisa; Fussi, Barbara; Heinze, Berthold; Wegmann, Daniel; Lexer, Christian

    2016-06-01

    Natural hybrid zones have proven to be precious tools for understanding the origin and maintenance of reproductive isolation (RI) and therefore species. Most available genomic studies of hybrid zones using whole- or partial-genome resequencing approaches have focused on comparisons of the parental source populations involved in genome admixture, rather than exploring fine-scale patterns of chromosomal ancestry across the full admixture gradient present between hybridizing species. We have studied three well-known European 'replicate' hybrid zones of Populus alba and P. tremula, two widespread, ecologically divergent forest trees, using up to 432 505 single-nucleotide polymorphisms (SNPs) from restriction site-associated DNA (RAD) sequencing. Estimates of fine-scale chromosomal ancestry, genomic divergence and differentiation across all 19 poplar chromosomes revealed strikingly contrasting results, including an unexpected preponderance of F1 hybrids in the centre of genomic clines on the one hand, and genomically localized, spatially variable shared variants consistent with ancient introgression between the parental species on the other. Genetic ancestry had a significant effect on survivorship of hybrid seedlings in a common garden trial, pointing to selection against early-generation recombinants. Our results indicate a role for selection against recombinant genotypes in maintaining RI in the face of apparent F1 fertility, consistent with the intragenomic 'coadaptation' model of barriers to introgression upon secondary contact. Whole-genome resequencing of hybridizing populations will clarify the roles of specific genetic pathways in RI between these model forest trees and may reveal which loci are affected most strongly by its cyclic breakdown. © 2016 John Wiley & Sons Ltd.

  2. Measurements of thoron and radon progeny concentrations in Beijing, China

    International Nuclear Information System (INIS)

    Zhang Lei; Liu Cuihong; Guo Qiuju

    2008-01-01

    It has been reported that thoron levels in China are above the world average and may therefore make a significant contribution to the natural background radiation dose. We therefore conducted a pilot study of concentrations of both thoron and radon progeny during the spring of 2006 in the Beijing area, China. A new type of portable 24 h integrating monitor with a CR-39 detector was used during the survey. Seventy dwellings and eight outdoor sites were measured during the survey. For country houses built of red bricks and slurry, the average equilibrium equivalent concentrations (EEC) of thoron and radon were 1.02 ± 0.48 and 16.41 ± 9.02 Bq m -3 , respectively, whereas for city dwellings built of cement blocks and floor slabs, the results were 0.48 ± 0.47 and 11.50 ± 6.99 Bq m -3 for thoron and radon, respectively. For outdoor air, concentrations of thoron and radon progeny were 0.29 ± 0.28 and 7.05 ± 2.68 Bq m -3 , respectively. Radiation exposures from thoron and radon progeny were also evaluated; the ratio of dose contribution from thoron progeny to that of radon progeny was evaluated to be 28% and 17% in country houses and city dwellings, respectively. (note)

  3. Factors affecting daughters distribution among progeny testing Holstein bulls

    Directory of Open Access Journals (Sweden)

    Martino Cassandro

    2012-01-01

    Full Text Available The aim of this study was to investigate factors influencing the number of daughters of Holstein bulls during the progeny testing using data provided by the Italian Holstein Friesian Cattle Breeders Association. The hypothesis is that there are no differences among artificial insemination studs (AIS on the daughters distribution among progeny testing bulls. For each bull and beginning from 21 months of age, the distribution of daughters over the progeny testing period was calculated. Data were available on 1973 bulls born between 1986 and 2004, progeny tested in Italy and with at least 4 paternal half-sibs. On average, bulls exited the genetic centre at 11.3±1.1 months and reached their first official genetic proof at 58.0±3.1 months of age. An analysis of variance was performed on the cumulative frequency of daughters at 24, 36, 48, and 60 months. The generalized linear model included the fixed effects of year of birth of the bull (18 levels, artificial insemination stud (4 levels and sire of bull (137 levels. All effects significantly affected the variability of studied traits. Artificial insemination stud was the most important source of variation, followed by year of birth and sire of bull. Significant differences among AI studs exist, probably reflecting different strategies adopted during progeny testing.

  4. Measurements of indoor radon and radon progeny in Mexico City

    International Nuclear Information System (INIS)

    Cheng, Y.S.; Rodriguez, G.P.

    1996-01-01

    Indoor radon has been a public concern associated with increased lung cancer risks. Radon decay products interact with indoor aerosols to form progeny with different size distributions, which may influence the lung dosimetry when the progeny are inhaled. Air pollution in Mexico City is a serious problems with high particulate concentrations, but there are few reports of indoor radon measurement. The purposes of this study were to measure the aerosol concentration, radon concentration, and radon activity size distribution in the living area of three houses in Mexico City. The radon concentration was monitored by a RGM-3 radon gas monitor (Eberline, Inc., Santa Fe, NM). A graded diffusion battery was used to determine the progeny concentration and activity size distribution. The concentration and size distribution of the indoor aerosols were monitored by a quartz, crystal microbalance cascade impactor. Our measurements showed high concentrations of indoor aerosols (20-180 gg m -3 ). However, the radon concentrations-were low ( -1 ), but showed a clear diurnal pattern with peak concentrations from 2-10 AM. The activity size distributions of radon progeny were trimodal, with peaks of 0.6 nm, 4-5 nm, and 100 rim. Most activities were associated with large particle sizes. Our results indicated that indoor radon concentration was not high, due in part to a relatively high air exchange with outdoor air. The high aerosol concentration may also play an important part in the activity size distribution of radon progeny

  5. Predation as the primary selective force in recurrent evolution of gigantism in Poecilozonites land snails in Quaternary Bermuda

    Science.gov (United States)

    Olson, Storrs L.; Hearty, Paul J.

    2010-01-01

    During the last half million years, pulses of gigantism in the anagenetic lineage of land snails of the subgenus Poecilozonites on Bermuda were correlated with glacial periods when lower sea level resulted in an island nearly an order of magnitude larger than at present. During those periods, the island was colonized by large vertebrate predators that created selection pressure for large size and rapid growth in the snails. Extreme reduction in land area from rising seas, along with changes in ecological conditions at the onset of interglacial episodes, marked extinction events for large predators, after which snails reverted to much smaller size. The giant snails were identical in morphology during the last two glacials when the predators included a large flightless rail Rallus recessus (marine isotope stages (MIS) 4-2) and a crane Grus latipes and a duck Anas pachysceles (MIS 6). In a preceding glacial period (MIS 10), when the fauna also included the tortoise Hesperotestudo bermudae, the snails were not only large, but the shells were much thicker, presumably to prevent crushing by tortoises. Evolution of Poecilozonites provides an outstanding example of dramatic morphological change in response to environmental pressures in the absence of cladogenesis. PMID:20554560

  6. Recurrent vulvovaginitis.

    Science.gov (United States)

    Powell, Anna M; Nyirjesy, Paul

    2014-10-01

    Vulvovaginitis (VV) is one of the most commonly encountered problems by a gynecologist. Many women frequently self-treat with over-the-counter medications, and may present to their health-care provider after a treatment failure. Vulvovaginal candidiasis, bacterial vaginosis, and trichomoniasis may occur as discreet or recurrent episodes, and have been associated with significant treatment cost and morbidity. We present an update on diagnostic capabilities and treatment modalities that address recurrent and refractory episodes of VV. Copyright © 2014 Elsevier Ltd. All rights reserved.

  7. Measurement of radon and thoron progenies in Coimbatore

    International Nuclear Information System (INIS)

    Sivakumar, R.; Selvasekarapandian, S.; Mahendraprasad, M.; Meenakshisundaram, V.; Santhanam, R.; Raghunath, V.M.

    2001-01-01

    The radon and thoron daughter concentrations have been measured in different dwellings of Coimbatore city by grab sampling method and two count. It has been found that the radon daughter concentration varies from 0.5 to 10.5 mWL with mean value of 2.9 mWL and that of thoron progeny is from 0.7 to 16.3 mWL with mean value of 3.8 mWL. The average annual effective dose equivalent due to radon daughters is found to be 1.3 mSv and that of thoron progeny is 3.8 mSv. (author)

  8. Microdosimetry of radon progeny: Application to risk assessment

    International Nuclear Information System (INIS)

    Fisher, D.R.; Hui, T.E.; James, A.C.; Bond, V.P.

    1990-01-01

    We developed methods for calculating radiation doses to individual cells and cell nuclei of human bronchial epithelium from radon and progeny for specified levels of exposure, breathing rates, equilibrium factors, unattached fraction of progeny, and other factors that are important in radon dosimetry. If we also know which cells are likely precursors for cancer, and we also know their locations in the respiratory tract, we then may calculate the statistical probability that these cells are irradiated by alpha particles, the number of single alpha-particle hits, and the spectrum of doses delivered as a probability density in specific energy

  9. Radionuclide supply of the progeny via mother's milk

    International Nuclear Information System (INIS)

    Ovcharenko, E.P.

    1982-01-01

    While examining transition of radioactive substances from material organism to milk and then radionuclide administration with milk to progeny, a number of relationships had been revealed. They are similar to those discovered by the author during his study on transplacental radionuclide kinetics. The quantity of transition through placental and milk barriers of group 2 Periodical system radionuclides is inversally proportional to radionuclide mass number. There is evidence for the increase of radionuclide transition per different kinds of animal progeny mass unit during pregnancy as well as during lactation [ru

  10. Inheritance of oilseed rape (Brassica napus) RAPD markers in a backcross progeny with Brassica campestris

    DEFF Research Database (Denmark)

    Mikkelsen, T.R.; Jensen, J.; Bagger Jørgensen, Rikke

    1996-01-01

    Different cultivars/transgenic lines of oilseed rape (Brassica napus) were crossed (as females) with different cultivars/populations of Brassica campestris. All cross combinations produced seed, with an average seed set per pollination of 9.8. Backcrossing of selected interspecific hybrids (as...... females) to B. campestris resulted in a much lower seed set, average 0.7 seed per pollination. In the single backcross progeny where a large enough population (92 plants) was obtained for analysis, 33 B. napus specific RAPD markers were investigated to determine the extent of transfer of oilseed rape...

  11. Genetic Gains in Grain Yield of a Maize Population Improved through Marker Assisted Recurrent Selection under Stress and Non-stress Conditions in West Africa

    Directory of Open Access Journals (Sweden)

    Rekiya O. Abdulmalik

    2017-05-01

    Full Text Available Marker-assisted recurrent selection (MARS is a breeding method used to accumulate favorable alleles that for example confer tolerance to drought in inbred lines from several genomic regions within a single population. A bi-parental cross formed from two parents that combine resistance to Striga hermonthica with drought tolerance, which was improved through MARS, was used to assess changes in the frequency of favorable alleles and its impact on inbred line improvement. A total of 200 testcrosses of randomly selected S1 lines derived from the original (C0 and advanced selection cycles of this bi-parental population, were evaluated under drought stress (DS and well-watered (WW conditions at Ikenne and under artificial Striga infestation at Abuja and Mokwa in Nigeria in 2014 and 2015. Also, 60 randomly selected S1 lines each derived from the four cycles (C0, C1, C2, C3 were genotyped with 233 SNP markers using KASP assay. The results showed that the frequency of favorable alleles increased with MARS in the bi-parental population with none of the markers showing fixation. The gain in grain yield was not significant under DS condition due to the combined effect of DS and armyworm infestation in 2015. Because the parents used for developing the bi-parental cross combined tolerance to drought with resistance to Striga, improvement in grain yield under DS did not result in undesirable changes in resistance to the parasite in the bi-parental maize population improved through MARS. MARS increased the mean number of combinations of favorable alleles in S1 lines from 114 in C0 to 124 in C3. The level of heterozygosity decreased by 15%, while homozygosity increased by 13% due to the loss of some genotypes in the population. This study demonstrated the effectiveness of MARS in increasing the frequency of favorable alleles for tolerance to drought without disrupting the level of resistance to Striga in a bi-parental population targeted as a source of improved

  12. Genetic Gains in Grain Yield of a Maize Population Improved through Marker Assisted Recurrent Selection under Stress and Non-stress Conditions in West Africa.

    Science.gov (United States)

    Abdulmalik, Rekiya O; Menkir, Abebe; Meseka, Silvestro K; Unachukwu, Nnanna; Ado, Shehu G; Olarewaju, Joseph D; Aba, Daniel A; Hearne, Sarah; Crossa, Jose; Gedil, Melaku

    2017-01-01

    Marker-assisted recurrent selection (MARS) is a breeding method used to accumulate favorable alleles that for example confer tolerance to drought in inbred lines from several genomic regions within a single population. A bi-parental cross formed from two parents that combine resistance to Striga hermonthica with drought tolerance, which was improved through MARS, was used to assess changes in the frequency of favorable alleles and its impact on inbred line improvement. A total of 200 testcrosses of randomly selected S 1 lines derived from the original (C 0 ) and advanced selection cycles of this bi-parental population, were evaluated under drought stress (DS) and well-watered (WW) conditions at Ikenne and under artificial Striga infestation at Abuja and Mokwa in Nigeria in 2014 and 2015. Also, 60 randomly selected S 1 lines each derived from the four cycles (C 0 , C 1 , C 2 , C 3 ) were genotyped with 233 SNP markers using KASP assay. The results showed that the frequency of favorable alleles increased with MARS in the bi-parental population with none of the markers showing fixation. The gain in grain yield was not significant under DS condition due to the combined effect of DS and armyworm infestation in 2015. Because the parents used for developing the bi-parental cross combined tolerance to drought with resistance to Striga , improvement in grain yield under DS did not result in undesirable changes in resistance to the parasite in the bi-parental maize population improved through MARS. MARS increased the mean number of combinations of favorable alleles in S 1 lines from 114 in C 0 to 124 in C 3 . The level of heterozygosity decreased by 15%, while homozygosity increased by 13% due to the loss of some genotypes in the population. This study demonstrated the effectiveness of MARS in increasing the frequency of favorable alleles for tolerance to drought without disrupting the level of resistance to Striga in a bi-parental population targeted as a source of improved

  13. A radon progeny sampler for the determination of effective dose

    Energy Technology Data Exchange (ETDEWEB)

    Solomon, S.B. [Australian Radiation Laboratory, Victoria (Australia)

    1997-12-01

    The design and simulated performance is described of a two-stage sampler (HE-Sampler) for {sup 222}Rn progeny. This HE-Sampler has a collection efficiency optimised to match the particle size dependency of the radon progeny dose conversion factor (DCF), derived from the latest Respiratory Tract Model of the International Commission on Radiological Protection, as implemented in the computer code RADEP. The He-Sampler comprises a wire screen pre-separator, matched to the nasal deposition, and a wire screen collector, matched to the respiratory tract collection. This HE-Sampler allows for the estimation of the radiation dose from the inhalation of {sup 222}Rn progeny, derived from two concurrent alpha particle activity measurements, one on the HE-Sampler screen collector and one on a reference filter sample. As a first approximation, the DCF is proportional to the collected fraction. The HE-Sampler response was simulated for a range of radon progeny size distributions to determine the error in the estimated DCF values. The simulation results show that the HE-Sampler is relatively insensitive to variations in sampling rate and in the screen parameters, particularly for environmental exposure. (Author).

  14. Studies on thoron progeny implantation in different materials

    International Nuclear Information System (INIS)

    Cosma, C.; Flore, A.; Pop, I.

    2003-01-01

    The purpose of this work is to obtain the alpha spectra for thoron daughters implanted at the surface of different materials and to show the possibility of this method to simulate the radon progeny implantation and thus to find some parameters used in the Jacobi model

  15. Concentration of Radon Progeny in Air by Alpha Spectrometry Measurement

    International Nuclear Information System (INIS)

    Acena, M. L.; Crespo, M. T.

    1989-01-01

    The concentration of radon progeny in air has been determined by alpha spectrometry measurement of 214 Po and 318 Po. A known volume of air was passed through a filter, then the alpha activity was directly measured on this filter. (Author) 15 refs

  16. Parentage assignment of progeny in mixed milt fertilization of ...

    African Journals Online (AJOL)

    Parentage of a stock of mixed milt produced progeny in current artificial breeding protocol of endangered Caspian brown trout, Salmo trutta caspius, was determined using three microsatellite loci chosen after a primary analysis of genetic diversity at nine microsatellite loci in the eight used breeder individuals. Overall ...

  17. Control of indoor radon and radon progeny concentrations

    International Nuclear Information System (INIS)

    Sextro, R.G.

    1985-05-01

    There are three general categories of techniques for the control of radon and radon progeny concentrations in indoor air - restriction of radon entry, reduction of indoor radon concentrations by ventilation or air cleaning, and removal of airborne radon progeny. The predominant radon entry process in most residences appears to be pressure driven flow of soil gas through cracks or other openings in the basement, slab, or subfloor. Sealing these openings or ventilation of the subslab or subfloor space are methods of reducing radon entry rates. Indoor radon concentrations may be reduced by increased ventilation. The use of charcoal filters for removal of radon gas in the indoor air by adsorption has also been proposed. Concentrations of radon progeny, which are responsible for most of the health risks associated with radon exposures, can be controlled by use of electrostatic or mechanical filtration. Air circulation can also reduce radon progeny concentrations in certain cases. This paper reviews the application and limitations of each of these control measures and discusses recent experimental results

  18. Effect of calving distribution on beef cattle progeny performance.

    Science.gov (United States)

    Funston, R N; Musgrave, J A; Meyer, T L; Larson, D M

    2012-12-01

    Records collected between 1997 and 2010 were used to determine the effect of calving period on heifer (n = 1,019) and steer (n = 771) progeny from the Gudmundsen Sandhills Laboratory, Whitman, NE. Progeny were classified as being born in the first, second, or third 21-d period of the spring calving season within year. Heifer birth BW was lightest (P Birth to weaning ADG tended (P = 0.10) to be least for heifers born in the first calving period; however, weaning BW decreased (P = 0.03) with advancing calving period. Weaning to prebreeding ADG tended (P = 0.07) to be least for heifers born in the first period; however, prebreeding BW was greatest (P rates were lowest (P = 0.02) for heifers born in the third calving period (90, 86, and 78%, respectively). Birth date of the first calf of the heifer and birth BW decreased (P rates compared with heifers born in the third period. First calf progeny also had an earlier birth date and greater weaning BW. Steer calves born during the first 21 d of the calving season had greater weaning, final, and carcass weights; greater marbling scores; a greater percentage grading USDA modest or greater; and greater carcass value. Calving period of progeny significantly impacts performance.

  19. The study of triploid progenies crossed between different ploidy ...

    African Journals Online (AJOL)

    The study of triploid progenies crossed between different ploidy grapes. L Sun, G Zhang, A Yan, H Xu. Abstract. The cross between different ploidy grape was one of the effective ways to obtain new seedless cultivars, in this study, through testing the changes of the ovule weight and observing its anatomical structure, the ...

  20. Experimental alternatives for evaluation of progenies and clones in eucalyptus breeding programs

    Directory of Open Access Journals (Sweden)

    Souza Elaine Aparecida de

    2003-01-01

    Full Text Available The feasibility of using augmented block designs and spatial analysis methods for early stage selection in eucalyptus breeding programs was tested. A total of 113 half-sib progenies of Eucalyptus urophylla and eight clones were evaluated in an 11 x 11 triple lattice experiment at two locations: Posto da Mata (Bahia, Brazil and São Mateus (Minas Gerais, Brazil. Four checks were randomly allocated within each block. Plots consisted of 15 m long rows containing 6 plants spaced 3 m apart. The girth at breast height (cm/plant was evaluated at 19 and 26 months of age. Variance analyses were performed according to the following methods: lattice design, randomized complete block design, augmented block design, Papadakis method, moving means method, and check plots. Comparisons among different methods were based on the magnitude of experimental errors and precision of the estimates of genetic and phenotypic parameters. General results indicated that augmented block design is useful to evaluate progenies and clones in early selection in eucalyptus breeding programs using moderate and low selection intensities. However, this design is not suitable for estimating genetic and phenotypic parameters due to its low precision. Check plots, nearest neighbour, Papadakis (1937, and moving means methods were efficient in removing the heterogeneity within blocks. These efficiencies were compared to that in lattice analysis for estimation of genetic and phenotypic parameters.

  1. Recurrent emergence of structural variants of LTR retrotransposon CsRn1 evolving novel expression strategy and their selective expansion in a carcinogenic liver fluke, Clonorchis sinensis.

    Science.gov (United States)

    Kim, Seon-Hee; Kong, Yoon; Bae, Young-An

    2017-06-01

    Autonomous retrotransposons, in which replication and transcription are coupled, encode the essential gag and pol genes as a fusion or separate overlapping form(s) that are expressed in single transcripts regulated by a common upstream promoter. The element-specific expression strategies have driven development of relevant translational recoding mechanisms including ribosomal frameshifting to satisfy the protein stoichiometry critical for the assembly of infectious virus-like particles. Retrotransposons with different recoding strategies exhibit a mosaic distribution pattern across the diverse families of reverse transcribing elements, even though their respective distributions are substantially skewed towards certain family groups. However, only a few investigations to date have focused on the emergence of retrotransposons evolving novel expression strategy and causal genetic drivers of the structural variants. In this study, the bulk of genomic and transcribed sequences of a Ty3/gypsy-like CsRn1 retrotransposon in Clonorchis sinensis were analyzed for the comprehensive examination of its expression strategy. Our results demonstrated that structural variants with single open reading frame (ORF) have recurrently emerged from precedential CsRn1 copies encoding overlapping gag-pol ORFs by a single-nucleotide insertion in an upstream region of gag stop codon. In the parasite genome, some of the newly evolved variants appeared to undergo proliferative burst as active master lineages together with their ancestral copies. The genetic event was similarly observed in Opisthorchis viverrini, the closest neighbor of C. sinensis, whereas the resulting structural variants might have failed to overcome purifying selection and comprised minor remnant copies in the Opisthorchis genome. Copyright © 2017 Elsevier B.V. All rights reserved.

  2. Growth variation and heritability in a second-generation Eucalyptus urophylla progeny test at Lad Krating Plantation, Chachoengsao province, Thailand

    Directory of Open Access Journals (Sweden)

    Lucky Nhlanhla Dlamini

    2017-06-01

    Full Text Available In Thailand, Eucalyptus urophylla was introduced with the main purpose of supplying raw material for pulp and chip wood production. The demand for genetically improved seed is increasing to support high productivity plantation establishment. One of the tree improvement activities established to meet the high demand for improved seed was a second generation progeny test at Lad Krating Plantation, Thailand to provide the best material for the successful plantation program. The aim of the current study was to compare growth variation of the first and second generation of Eucalyptus urophylla progeny that could provide information on suitable families for improved quality seed. The progeny test comprised the best 45 half-sib families selected from 80 half-sib families of the first-generation progeny test. The design of the progeny test was a randomized and complete block design (16 trees/plot × 45 plots/block × 9 blocks, with 4 rows of 4 trees at a spacing of 2 m × 1 m. Growth was assessed at age 3 yr. The average height and diameter at breast height over bark (DBH, was 13.72 m, and 8.75 cm, respectively. There were highly significant (p < 0.01 differences among provenances and families in both height and DBH. The individual heritability values for height and DBH were 0.48 and 0.60, respectively. The family heritability values for height and DBH were 0.98 and 0.99, respectively. These 45 half-sib families proved to be genetically superior ensuring higher productivity and contributing to the success of the Forest Industry Organization plantation at Lad Krating.

  3. Sentinel Lymph Node Dissection to Select Clinically Node-negative Prostate Cancer Patients for Pelvic Radiation Therapy: Effect on Biochemical Recurrence and Systemic Progression

    Energy Technology Data Exchange (ETDEWEB)

    Grivas, Nikolaos, E-mail: n.grivas@nki.nl [Department of Urology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam (Netherlands); Wit, Esther [Department of Urology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam (Netherlands); Pos, Floris [Department of Radiation Oncology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam (Netherlands); Jong, Jeroen de [Department of Pathology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam (Netherlands); Vegt, Erik [Department of Nuclear Medicine, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam (Netherlands); Bex, Axel; Hendricksen, Kees; Horenblas, Simon [Department of Urology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam (Netherlands); KleinJan, Gijs [Department of Urology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam (Netherlands); Interventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, Leiden (Netherlands); Rhijn, Bas van; Poel, Henk van der [Department of Urology, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam (Netherlands)

    2017-02-01

    Purpose: To assess the efficacy of robotic-assisted laparoscopic sentinel lymph node (SLN) dissection (SLND) to select those patients with prostate cancer (PCa) who would benefit from additional pelvic external beam radiation therapy and long-term androgen deprivation therapy (ADT). Methods and Materials: Radioisotope-guided SLND was performed in 224 clinically node-negative patients scheduled to undergo external beam radiation therapy. Patients with histologically positive SLNs (pN1) were also offered radiation therapy to the pelvic lymph nodes, combined with 3 years of ADT. Biochemical recurrence (BCR), overall survival, and metastasis-free (including pelvic and nonregional lymph nodes) survival (MFS) rates were retrospectively calculated. The Briganti and Kattan nomogram predictions were compared with the observed pN status and BCR. Results: The median prostate-specific antigen (PSA) value was 15.4 ng/mL (interquartile range [IQR] 8-29). A total number of 834 SLNs (median 3 per patient; IQR 2-5) were removed. Nodal metastases were diagnosed in 42% of the patients, with 150 SLNs affected (median 1; IQR 1-2). The 5-year BCR-free and MFS rates for pN0 patients were 67.9% and 87.8%, respectively. The corresponding values for pN1 patients were 43% and 66.6%. The PSA level and number of removed SLNs were independent predictors of BCR and MFS, and pN status was an additional independent predictor of BCR. The 5-year overall survival rate was 97.6% and correlated only with pN status. The predictive accuracy of the Briganti nomogram was 0.665. Patients in the higher quartiles of Kattan nomogram prediction of BCR had better than expected outcomes. The complication rate from SLND was 8.9%. Conclusions: For radioisotope-guided SLND, the high staging accuracy is accompanied by low morbidity. The better than expected outcomes observed in the lower quartiles of BCR prediction suggest a role for SLN biopsy as a potential selection tool for the addition of pelvic radiation

  4. Radon progeny dose conversion coefficients for Chinese males and females

    Energy Technology Data Exchange (ETDEWEB)

    Yu, K.N. E-mail: peter.yu@city.edu.hk; Cheung, T.T.K.; Haque, A.K.M.M.; Nikezic, D.; Lau, B.M.F.; Vucic, D

    2001-07-01

    The airway dimensions for Caucasian males have been scaled by multiplying by factors 0.95 and 0.88 to give those for Chinese males and females, respectively. Employing the most recent data on physical and biological parameters, the radiation doses to the basal and secretory cells due to {alpha} particles from {sup 218}Po and {sup 214}Po, homogeneously distributed in the mucous layer, have been calculated. The emission of {alpha} particles has been simulated by a Monte Carlo method. For both basal and secretory cells, the dose conversion coefficients (DCCs) for physical conditions of sleep, rest, light and heavy exercise, have been obtained for Chinese males and females for unattached progeny, and for attached progeny of diameters 0.02, 0.15, 0.25, 0.30 and 0.50 {mu}m. For basal cells, the coefficients lie in the range 0.69-6.82 mGy/(J s/m{sup 3}) or 8.7-86 mGy/WLM for unattached progeny and in the range 0.045-1.98 mGy/(J s/m{sup 3}) or 0.57-25 mGy/WLM for attached progeny. The corresponding ranges for Caucasian males are 1.27-8.81 mGy/(J s/m{sup 3}) or 16-111 mGy/WLM{sup -1} and 0.05-2.30 mGy/(J s/m{sup 3}) or 0.64-29 mGy/WLM. For secretory cells, the coefficients lie in the range 0.095-16.82 mGy/(J s/m{sup 3}) (1.2-212 mGy/WLM) for unattached progeny and in the range 0.095-6.67 mGy/(J s/m{sup 3}) (1.2-84 mGy/WLM) for attached progeny. The corresponding ranges for Caucasian males are 0.34-21.51 mGy/(J s/m{sup 3}) (4.3-271 mGy/WLM) and 0.1-7.78 mGy/(J s/m{sup 3}) (1.3-98 mGy/WLM). The overall DCCs calculated for a typical home environment are 0.59 and 0.52 mSv/(J s/m{sup 3}) (7.4 and 6.5 mSv/WLM) for Chinese males and females, respectively, which are 80 and 70% of the value, 0.73 mSv/(J s/m{sup 3}) (9.2 mSv/WLM), for Caucasian males.

  5. Distribution characteristics of radon and its progeny in blind roadway with forced ventilation

    International Nuclear Information System (INIS)

    Ye Yongjun; Zhou Xinghuo; Li Xiangyang; Zhong Yongming; Liu Dong; Ding Dexin

    2012-01-01

    The blind roadway is not only the important workplaces, but also is important site of radon and its progeny generating and gathering, it is an important guiding significance for ventilation protection design to study distribution characteristics of radon and its progeny in blind roadway. Therefore, at first, the paper expounded the mathematical relationship between radon activity concentration with alpha potential concentration of radon progeny. Then, analyzed the sources of radon and its progeny, and established mathematical calculation model of Distribution characteristics of radon and its progeny in blind roadway with forced ventilation, respectively. Finally, using mathematical calculation models to analyze the influence law of multiple factors. (authors)

  6. Measurement of unattached radon progeny based in electrostatic deposition method

    International Nuclear Information System (INIS)

    Canoba, A.C.; Lopez, F.O.

    1999-01-01

    A method for the measurement of unattached radon progeny based on its electrostatic deposition onto wire screens, using only one pump, has been implemented and calibrated. The importance of being able of making use of this method is related with the special radiological significance that has the unattached fraction of the short-lived radon progeny. Because of this, the assessment of exposure could be directly related to dose with far greater accuracy than before. The advantages of this method are its simplicity, even with the tools needed for the sample collection, as well as the measurement instruments used. Also, the suitability of this method is enhanced by the fact that it can effectively be used with a simple measuring procedure such as the Kusnetz method. (author)

  7. Measurement of size distribution for 220Rn progeny attached aerosols

    International Nuclear Information System (INIS)

    Zhang Lei; Guo Qiuju; Zhuo Weihai

    2008-01-01

    The size distribution of radioactive aerosols is a very important factor for evaluating the inner exposure dose contributed by radon and thoron progeny in environments. In order to measure the size distribution of thoron progeny attached radioactive aerosols, a device was developed using wire screens. The count median diameter (CMD) and the geometric standard deviation (GSD) of attached radioactive aerosols were calculated by collecting ThB and using CR-39 as detector. Field measurement results at Yangjiang City in Guangdong Province show that the CMDs distribute between 30 and 130 nm, and the GSDs are between 1.9 and 3.3. It also shows that the more humid country, the smaller CMDs, and the ventilation has great influence on the size distribution of aerosols. The CMDs of adobe house are smaller than that of the concrete houses. (authors)

  8. SENSITIVITY OF MORNINGGLORY PLANTS AND THEIR PROGENIES TO GLUFOSINATE AMMONIUM

    OpenAIRE

    BRITO, I.P.F.S.; MORAES, C.P.; MARCHESI, B.B.; CARBONARI, C.A.; VELINI, E.D.

    2017-01-01

    ABSTRACT The sensitivity of weed species to herbicides is variable, and the behavior can be repeated or not in the next generation. The objective of this study was to evaluate the response of morningglory plants to different doses of glufosinate ammonium and the sensitivity of plant populations and their progenies to the herbicide. Three studies were conducted, all in a greenhouse and repeated in two periods. In the first study, two experiments were conducted to examine the dose-response curv...

  9. Proceedings of radon and radon progeny measurements in Australia symposium

    International Nuclear Information System (INIS)

    Akber, R.A.; Harris, F.

    1994-01-01

    This publication contain papers presented at a symposium on radon and radon progeny measurements in Australia, held in Canberra on 18 February 1994. The emphasis was on results of measurements in different exposure situations, however information on methodology and techniques was also included. The scope of the symposium expanded through participation by scientists from China, French Polynesia and New Zealand. A list of participants and their organizations is included at the end of the proceedings. refs., tabs., figs

  10. Cellular dosimetry for radon progeny alpha particles in bronchial tissue

    International Nuclear Information System (INIS)

    Mohamed, A.; Hofmann, W.; Balashazy, I.

    1996-01-01

    Inhaled radon progeny are deposited in different regions of the human bronchial tree as functions of particle size and flow rate. Following deposition and mucociliary clearance, the sensitive bronchial basal and secretory cells are irradiated by two different alpha particle sources: (i) radon progeny in the sol and/or gel phase of the mucous layer, and (ii) radon progeny within the bronchial epithelium. In the case of internally deposited radionuclides, direct measurement of the energy absorbed from the ionizing radiation emitted by the decaying radionuclides is rarely, if ever, possible. Therefore, one must rely on dosimetric models to obtain estimates of the spatial and temporal patterns of energy deposition in tissues and organs of the body. When the radionuclide is uniformly distributed throughout the volume of a tissue of homogeneous composition and when the size of the tissue is large compared to the range of the particulate emissions of the radionuclide, then the dose rate within the tissue is also uniform and the calculation of absorbed dose can proceed without complication. However, if non-uniformities in the spatial and temporal distributions of the radionuclide are coupled with heterogeneous tissue composition, then the calculation of absorbed dose becomes complex and uncertain. Such is the case with the dosimetry of inhaled radon and radon progeny in the respiratory tract. There are increasing demands to obtain a definitive explanation of the role of alpha particles emitted from radon daughters in the induction of lung cancer. Various authors have attempted to evaluate the dose to the bronchial region of the respiratory tract due to the inhalation of radon daughters

  11. Measurements of radon progeny activity on typical indoor surfaces

    International Nuclear Information System (INIS)

    Knutson, E.O.; Gogolak, C.V.; Klemic, G.

    1992-01-01

    A number of studies aimed at defining how well radon progeny on surfaces can be measured, information that is needed in order to test physical/mathematical models governing indoor radon progeny behaviour, are described. One experiment compared the decomposition on to different surfaces. Only relatively small differences were found among metal, filter paper, broadcloth, corduroy fabric, vinyl wallpaper, glass, and latex paint, but polyethylene film collected two to four times as much as the others, due most likely to electrostatic charge on the plastic surface. Another experiment compared the gamma and gross alpha count methods of measuring surface activity for metal, filter paper, broadcloth and corduroy surfaces. No difference for the surfaces tested was found from which it is concluded that, even for rougher surfaces, progeny atoms deposit mainly on the outer layers. A final experiment compared in situ and surrogate-surface methods for measuring surface deposition. For most tests, the two methods agreed within 30%, and the average ratio was not significantly different from unity. 210 Po is a complication in the in situ method. An unexpected location effect was found in the experiments conducted in houses with high radon concentrations: the deposition on the ceiling was higher than on the surfaces. (author)

  12. Chromosomal instability in the progeny of irradiated parents

    International Nuclear Information System (INIS)

    Voro btsova, I.E.; Vorobyova, M.V.; Bogomazova, A.N.

    1997-01-01

    Genomic instability have been demonstrated in irradiated cells as the increased frequency of sporadic chromosome aberrations persisted over multiple generations of cell divisions. We found that chromosomal instability characterized as well the somatic cells of irradiated parents progeny. It means that radiation induced genomic instability can be transmitted via germ line cells. As a measure of instability the sensitivity of chromosomes to radiation was estimated. In animal experiments the irradiation of mature germ cells of male rats (dose - 4.5 Gy of X-rays) increase the frequency of chromosome aberrations induced by challenging irradiation in regenerating hepatocytes, in bone marrow cells and in fetal fibroblasts in the progeny of irradiated male rats. The chromosomal sensitivity of cultivated lymphocytes to in vitro irradiation (1.5 Gy of γ(rays 137 Cs) is increased in the children born parents undergone antitumor radiotherapy or worked as 'liquidators' of Chernobyl accident consequences before conception in comparison to the children of unexposed parents. The cytogenetic radiosensitivity of lymphocytes to irradiation in vitro is also increased in children evacuated from contaminated by radionuclides areas ('positive' control group). The increased spontaneous frequency of chromatid-type acentric was found in all group of children with irradiation history. The instability of genome of irradiated parents progeny seems could be the mechanism of these health effects. (authors)

  13. Control of radon and its progeny concentration in indoor atmosphere

    International Nuclear Information System (INIS)

    Ramachandran, T.V.; Subbaramu, M.C.

    1986-01-01

    Exposure to radon daughter concentration in indoor atmosphere can result in a significant risk to the general public. There are two generally used methods for the control of radon and progeny concentration in the indoor atmosphere, namely restriction of radon entry and reduction of indoor radon and its progeny concentration by ventilation or by air cleaning. Predominant radon entry process in most of the dwellings appears to be by pressure driven flow of soil gas through cracks or other openings in the basement slab or subfloors. Sealing these openings or ventilation of the subslab or subfloor space are the methods for reducing the radon entry rates. Indoor radon concentration can also be reduced by increasing the ventilation and by using charcoal filters for the removal of radon gas in indoor air by absorption. Concentration of radon progeny, which are responsible for most of the health risks associatd with radon exposure can also be controlled by the use of electrostatic or mechanical filters. This study describes briefly the above control strategies used for reducing the inhalation doses to persons in dwellings. (author). 9 refs., 2 tables

  14. Progeny Clustering: A Method to Identify Biological Phenotypes

    Science.gov (United States)

    Hu, Chenyue W.; Kornblau, Steven M.; Slater, John H.; Qutub, Amina A.

    2015-01-01

    Estimating the optimal number of clusters is a major challenge in applying cluster analysis to any type of dataset, especially to biomedical datasets, which are high-dimensional and complex. Here, we introduce an improved method, Progeny Clustering, which is stability-based and exceptionally efficient in computing, to find the ideal number of clusters. The algorithm employs a novel Progeny Sampling method to reconstruct cluster identity, a co-occurrence probability matrix to assess the clustering stability, and a set of reference datasets to overcome inherent biases in the algorithm and data space. Our method was shown successful and robust when applied to two synthetic datasets (datasets of two-dimensions and ten-dimensions containing eight dimensions of pure noise), two standard biological datasets (the Iris dataset and Rat CNS dataset) and two biological datasets (a cell phenotype dataset and an acute myeloid leukemia (AML) reverse phase protein array (RPPA) dataset). Progeny Clustering outperformed some popular clustering evaluation methods in the ten-dimensional synthetic dataset as well as in the cell phenotype dataset, and it was the only method that successfully discovered clinically meaningful patient groupings in the AML RPPA dataset. PMID:26267476

  15. External gamma exposure to radon progeny in indoor air

    International Nuclear Information System (INIS)

    Fujimoto, Kenzo

    1985-01-01

    The external γ-exposure from radon progeny uniformly distributed in indoor air was estimated by a computer program that was developed. This program can calculate the fluence rate, exposure rate and average energy for any given point in a room of any given size. As numerical example, the exposure rate normalized to unit airborne activity is presented, together with the fluence-weighted and exposure-weighted average photon energies, for a room of representative geometry containing radon progeny in equilibrium. To cover other conditions encountered in practice, quantitative evaluations are additionally presented of the effect on the exposure brought by changes in certain parameters, such as equilibrium factor, wall thickness, room size and receptor position. The study has quantitatively substantiated the prevailing postulate that the effective dose equivalent due to external exposure resulting from normal indoor concentrations of airborne radon progeny in the room of representative geometry should only amount to 0.04 % of that from the internal exposure from the same sources, and that it should be of similarly negligible order compared with internal exposure also in the case of other room geometries. (author)

  16. The study of thoron and radon progeny concentrations in dwellings in Japan

    International Nuclear Information System (INIS)

    Guo, Q.; Shimo, M.; Ikebe, Y.

    1992-01-01

    Ths paper aims to make a comparison of different concentrations of thoron ( 220 Rn) progeny and radon ( 222 Rn) progeny in different kinds of dwellings. The potential alpha energy concentrations and the effective dose equivalent caused by thoron and radon progeny, respectively, have also been estimated. The measurements were carried out in 23 dwellings. The results indicate that thoron progeny concentrations indoors might be strongly affected by the type of building material used. Traditional Japanese buildings made with mud may have high thoron progeny concentrations of about 3.52 Bq.m -3 and a concentration ratio of thoron progeny to radon progeny of about 0.5, whereas in concrete dwellings thoron progeny concentrations are about 0.72 Bq.m -3 and the concentration ratio of thoron progeny to radon progeny is about 0.1. The annual effective dose equivalent of thoron progeny is 1.23 mSv in mud dwellings and 0.25 mSv in concrete dwellings. (author)

  17. Deposition of radon progeny in nonhuman primate nasal airways

    International Nuclear Information System (INIS)

    Yeh, H.C.; Cheng, Y.S.; Morgan, K.T.

    1992-01-01

    Radon progeny are usually associated with ultrafine particles ranging in diameter from 0.001 to 0.005 μm for open-quotes unattachedclose quotes progeny and from 0.005 to 0.2 μm for those attached to indoor aerosols. To assess the health effects of inhaling indoor radon progeny, it is necessary to study the regional deposition of these inhaled ultrafine particles. Laboratory animals are often used in studies of the toxicity of inhaled particles and vapors. Information on the deposition of particles larger than 0.2 μm in the nasal passages of laboratory animals is available; however, there is little information on the deposition of particles smaller than 0.2 μm. In this report, we describe the use of nasal casts of a rhesus monkey to measure total deposition of ultrafine aerosols, including unattached 220 Rn progeny, in a unidirectional-flow inhalation exposure system. Deposition data were obtained for monodisperse silver aerosols with particle sizes ranging from 0.005 to 0.2 μm, at several inspiratory and expiratory flow rates that represented normal breathing as well as hypo- and hyperventiliation. In addition, we studied the deposition of unattached 22- Rn progeny, at particle sizes from 0.001 to 0.003 μm. The deposition efficiency decreased with increasing particle size, indicating that diffusion was the dominant deposition mechanism. The effect of flow rate was essentially negligible. Based on assumptions that turbulent flow and complete mixing of aerosols occur in the nasal airways, a general equation E = 1-exp (-a D b Q c ) for d p ≤ 0.2 μm, was derived, where E is the deposition efficiency, d p is the particle diameter, D is the diffusion coefficient, and Q is the flow rate. Constants a, b, and c are estimated from experimental data, for either inspiration or expiration. This mathematical expression will be useful for making modifications to both deposition and dosimetry models

  18. Intein-mediated Cre protein assembly for transgene excision in hybrid progeny of transgenic Arabidopsis.

    Science.gov (United States)

    Ge, Jia; Wang, Lijun; Yang, Chen; Ran, Lingyu; Wen, Mengling; Fu, Xianan; Fan, Di; Luo, Keming

    2016-10-01

    An approach for restoring recombination activity of complementation split-Cre was developed to excise the transgene in hybrid progeny of GM crops. Growing concerns about the biosafety of genetically modified (GM) crops has currently become a limited factor affecting the public acceptance. Several approaches have been developed to generate selectable-marker-gene-free GM crops. However, no strategy was reported to be broadly applicable to hybrid crops. Previous studies have demonstrated that complementation split-Cre recombinase restored recombination activity in transgenic plants. In this study, we found that split-Cre mediated by split-intein Synechocystis sp. DnaE had high recombination efficiency when Cre recombinase was split at Asp232/Asp233 (866 bp). Furthermore, we constructed two plant expression vectors, pCA-NCre-In and pCA-Ic-CCre, containing NCre866-In and Ic-CCre866 fragments, respectively. After transformation, parent lines of transgenic Arabidopsis with one single copy were generated and used for hybridization. The results of GUS staining demonstrated that the recombination activity of split-Cre could be reassembled in these hybrid progeny of transgenic plants through hybridization and the foreign genes flanked by two loxP sites were efficiently excised. Our strategy may provide an effective approach for generating the next generation of GM hybrid crops without biosafety concerns.

  19. Genetic trends in the expected progeny difference of the asymptotic weight of Nelore females

    Directory of Open Access Journals (Sweden)

    Analía del Valle Garnero

    2006-01-01

    Full Text Available There are few studies on weight covering the full life cycle of Zebu cattle, and there is no entire growth description or mean growth pattern for animals belonging to this breed. In order to provide such data, 1,158 Nelore females born between 1985 and 1995 were weighed 14,563 times from birth to full growth maturity, in ten herds spread over seven Brazilian states. The Von Bertalanffy, Brody, logistic and Gompertz non-linear models were used to obtain the asymptotic weights (A and the maturation rates (K. The (covariance and breeding value components for A and K were obtained by using the multiple trait derivative free restricted maximum likelihood method under the animal model. Genetic trends were calculated in function of the mean expected progeny differences (EPD for the trait (A or K divided by the number of animals according to their year of birth. The genetic trends of the expected progeny difference with reference to the date of birth of the cows were, on average, -6.5g y-1 for A and 2.0g y-1 for K, close to zero as confirmed by the low (0.0023 to 0.003 coefficient of regression values. The curve parameters are recommended as a selection criterion to reach precocity and avoid adult weight increase in the female herd.

  20. Divergência genética entre progênies de café robusta Genetic divergence among robusta coffe progenies

    Directory of Open Access Journals (Sweden)

    Milana Gonçalves Ivoglo

    2008-12-01

    recurrent selection and production of hybrids. The importance of the traits for divergence was, also, evaluated by the sequential discards the variables, according its relative contributions. The trial was carry out in an experimental field located in the Pólo Regional do Nordeste Paulista, Mococa-SP, using randomized blocks with 21 treatments and 24 replicates. The datas were analyzed by Tocher and UPGMA methods. The matrix of genetic divergence was gotten on the generalized Mahalanobis distance that it served of base for the formation of the groups. The employed methods had been efficient in detecting ample genetic variability between the evaluated progenies. Some groups of similarity had been identified. The IAC 2262, IAC 2290, IAC 2286, IAC 2292 and IAC 2291 progenies are indicated to compose programs of intercrosses, being considered the most promising in the attainment of segregantes populations or hybrid heterotics. The characteristics that had less contributed for the genetic divergence had been: canopy diameter before pruning, plant height before pruning and leaf area.

  1. Lung Deposition And Biological Effects Of Inhaled Radon Progenies

    International Nuclear Information System (INIS)

    Balashazy, I.; Farkas, A.; Szoke, I.; Moustafa, M.; Kudela, G.

    2010-01-01

    Inhaled radon progenies provide more than the half of natural radiation exposure. There is increasing evidence that the cellular distribution of radiation burden is an important factor regarding the biological response to ionisation radiation, thus, one of our tasks was the characterisation of the distribution of cellular exposure. Histological studies of former uranium miners presented strong correlation between primer deposition hot spots and neoplastic lesions. Most of these lesions were located along the carinal regions of the large bronchial airways. In the present work, computational fluid dynamics (CFD) approaches have been applied to simulate the deposition distribution of inhaled radon progenies along central human airways. The geometry and the cellular structure of epithelial lung tissue were numerically reconstructed based on anatomical and histological data. Single and multiple ha-hit and cellular dose distributions have been computed applying Monte Carlo modelling techniques at different breathing conditions. Figure 1. Deposition enhancement factor (EF) of inhaled radon progenies on a central airway bifurcation in airway generations 4-5 during light physical activity breathing condition. Size of scanning surface element is a 45μm side triangle. Left panel: EF max=1400,Dp=200 nm (attached). Right panel: EF max1290, Dp= 1 nm (unattached). Values of local per average deposition densities, that is, enhancement factors (Figure 1), hit probabilities and doses may be up to two-three orders of magnitude higher in the deposition hot spots than the average values. Dose calculations revealed that some cell clusters may receive high doses even at low exposure conditions. Applying the model to different radiation exposure conditions useful relations can be received regarding the linear-non threshold hypothesis

  2. Mass spectrometric studies of the cluster formation of radon progeny

    International Nuclear Information System (INIS)

    Gong, S.L.

    1993-01-01

    A new experimental system is developed to study the cluster formation of radon progeny with neutral molecules in the environment, which includes a modified mass spectrometer and a surface barrier detector. With the system, the cluster research is carried out at molecular level at which the mass of individual cluster formed is measured. A theory is also proposed to treat the cluster formation as a discrete process based on the ion-dipole and dipole-dipole interactions. Comparison between the theory and experiment is given. (author). 16 refs., 6 figs

  3. Mass spectrometric studies of the cluster formation of radon progeny

    Energy Technology Data Exchange (ETDEWEB)

    Gong, S L [Toronto Univ., ON (Canada). Dept. of Chemical Engineering and Applied Chemistry

    1994-12-31

    A new experimental system is developed to study the cluster formation of radon progeny with neutral molecules in the environment, which includes a modified mass spectrometer and a surface barrier detector. With the system, the cluster research is carried out at molecular level at which the mass of individual cluster formed is measured. A theory is also proposed to treat the cluster formation as a discrete process based on the ion-dipole and dipole-dipole interactions. Comparison between the theory and experiment is given. (author). 16 refs., 6 figs.

  4. Evaluation of indoor aerosol control devices and their effects on radon progeny concentrations

    International Nuclear Information System (INIS)

    Sextro, R.G.; Offerman, F.J.; Nazaroff, W.W.; Nero, A.V.; Revzan, K.; Yater, J.

    1984-01-01

    Eleven portable air cleaing devices have been evaluated for control of indoor concentrations of respirable particles, and their concomitant effects on radon progeny concentrations have been investigated. Of the devices we examined the electrostatic precipitators and extended surface filters had significant particle removal rates, while the particle removal rates for several small panel-filters, an ion-generator, and a pair of mixing fans were found to be negligible. The evaluation of radon progeny control produced similar results; the air cleaners which were effective in removing particles were also effective in reducing radon progeny concentrations. Futhermore, at the low particle concentrations, plateout of the unattached radon progeny was found to be a significant removal mechanism. The overall removal rates due to deposition of attached and unattached progeny have been estimated from these data, and the equilibrium factors for total and unattached progeny concentrations have been calculated as a function of particle concentration. (Author)

  5. Evaluation of indoor aerosol control devices and their effects on radon progeny concentrations

    International Nuclear Information System (INIS)

    Sextro, R.G.; Offermann, F.J.; Nazaroff, W.W.; Nero, A.V.; Revzan, K.L.; Yater, J.

    1984-02-01

    Eleven portable air cleaning devices have been evaluated for control of indoor concentrations of respirable particles, and their concomitant effects on radon progeny concentrations have been investigated. Of the devices we examined the electrostatic precipitators and extended surface filters had significant particle removal rates, while the particle removal rates for several small panel-filters, an ion-generator, and a pair of mixing fans were found to be negligible. The evaluation of radon progeny control produced similar results; the air cleaners which were effective in removing particles were also effective in reducing radon progeny concentrations. Furthermore, at the low particle concentrations, plateout of the unattached radon progeny was found to be a significant removal mechanism. The overall removal rates due to deposition of attached and unattached progeny have been estimated from these data, and the equilibrium factors for total and unattached progeny concentrations have been calculated as a function of particle concentration. 7 references, 2 figures

  6. Genetic Divergence in Eucalyptus camaldulensis Progenies in the Savanna Biome in Mato Grosso, Brazil.

    Directory of Open Access Journals (Sweden)

    Reginaldo Brito da Costa

    Full Text Available Assessing the parental genetic differences and their subsequent prediction of progeny performance is an important first step to assure the efficiency of any breeding program. In this study, we estimate the genetic divergence in Eucalyptus camaldulensis based on the morphological traits of 132 progenies grown in a savanna biome. Thus, a field experiment was performed using a randomized block design and five replications to compare divergences in total height, commercial height, diameter at breast height, stem form and survival rate at 48 months. Tocher's clustering method was performed using the Mahalanobis and Euclidian distances. The Mahalanobis distance seemed more reliable for the assessed parameters and clustered all of the progenies into fourteen major groups. The most similar progenies (86 accessions were clustered into Group I, while the most dissimilar (1 progeny represented Group XIV. The divergence analysis indicated that promising crosses could be made between progenies allocated in different groups for high genetic divergence and for favorable morphological traits.

  7. Short- and long-term variability of radon progeny concentration in dwellings in the Czech Republic.

    Science.gov (United States)

    Slezáková, M; Navrátilová Rovenská, K; Tomásek, L; Holecek, J

    2013-03-01

    In this paper, repeated measurements of radon progeny concentration in dwellings in the Czech Republic are described. Two distinct data sets are available: one based on present measurements in 170 selected dwellings in the Central Bohemian Pluton with a primary measurement carried out in the 1990s and the other based on 1920 annual measurements in 960 single-family houses in the Czech Republic in 1992 and repeatedly in 1993. The analysis of variance model with random effects is applied to data to evaluate the variability of measurements. The calculated variability attributable to repeated measurements is compared with results from other countries. In epidemiological studies, ignoring the variability of measurements may lead to biased estimates of risk of lung cancer.

  8. Lung dosimetry for inhaled radon progeny in smokers

    International Nuclear Information System (INIS)

    Baias, P. F.; Hofmann, W.; Winkler-Heil, R.; Cosma, C.; Duliu, O. G.

    2010-01-01

    Cigarette smoking may change the morphological and physiological parameters of the lung. Thus the primary objective of the present study was to investigate to what extent these smoke-induced changes can modify deposition, clearance and resulting doses of inhaled radon progeny relative to healthy non-smokers (NSs). Doses to sensitive bronchial target cells were computed for four categories of smokers: (1) Light, short-term (LST) smokers, (2) light, long-term (LLT) smokers, (3) heavy, short-term (HST) smokers and (4) heavy, long-term (HLT) smokers. Because of only small changes of morphological and physiological parameters, doses for the LST smokers hardly differed from those for NSs. For LLT and HST smokers, even a protective effect could be observed, caused by a thicker mucus layer and increased mucus velocities. Only in the case of HLT smokers were doses higher by about a factor of 2 than those for NSs, caused primarily by impaired mucociliary clearance, higher breathing frequency, reduced lung volume and airway obstructions. These higher doses suggest that the contribution of inhaled radon progeny to the risk of lung cancer in smokers may be higher than currently assumed on the basis of NS doses. (authors)

  9. Genetic Diversity and Relationships of Neolamarckia cadamba (Roxb. Bosser progenies through cluster analysis

    Directory of Open Access Journals (Sweden)

    M. Preethi Shree

    2018-04-01

    Full Text Available Genetic diversity analysis was conducted for biometric attributes in 20 progenies of Neolamarckia cadamba. The application of D2 clustering technique in Neolamarckia cadamba genetic resources resolved the 20 progenies into five clusters. The maximum intra cluster distance was shown by the cluster II. The maximum inter cluster distance was recorded between cluster III and V which indicated the presence of wider genetic distance between Neolamarckia cadamba progenies. Among the growth attributes, volume (36.84 % contributed maximum towards genetic divergence followed by bole height, basal diameter, tree height, number of branches in Neolamarckia cadamba progenies.

  10. Selection and characterization of glyphosate tolerance in birdsfoot trefoil (Lotus corniculatus)

    International Nuclear Information System (INIS)

    Boerboom, C.M.

    1989-01-01

    If birdsfoot trefoil (Lotus corniculatus L.) was tolerant to glyphosate [N-(phosphonomethyl)glycine], Canada thistle [Cirsium arvense (L.) Scop.] and other dicot weeds could be selectively controlled in certified seed production fields. Glyphosate tolerance in birdsfoot trefoil was identified in plants from the cultivar Leo, plants regenerated from tolerant callus, and selfed progeny of plants regenerated from callus. Plants from the three sources were evaluated in field studies for tolerance to glyphosate at rates up to 1.6 kg ae/ha. Plants of Leo selected for tolerance exhibited a twofold range in the rate required to reduce shoot weight 50% (I 50 s from 0.6 to 1.2 kg/ha glyphosate). Plants regenerated from tolerant callus had tolerance up to 66% greater than plants regenerated from unselected callus. Transgressive segregation for glyphosate tolerance was observed in the selfed progeny of two regenerated plants that both had I 50 s of 0.7 kg/ha glyphosate. The selfed progeny ranged from highly tolerant (I 50 of 1.5 kg/ha) to susceptible (I 50 of 0.5 kg/ha). Spray retention, 14 C-glyphosate absorption and translocation did not account for the differential tolerance of nine plants that were evaluated from the three sources. The specific activity of 5-enolpyruvylshikimate 3-phosphate (EPSP) synthase ranged from 1.3 to 3.5 nmol/min sm-bullet mg among the nine plants and was positively correlated with glyphosate tolerance. Leo birdsfoot trefoil was found to have significant variation in glyphosate tolerance which made it possible to initiate a recurrent selection program to select for glyphosate tolerance in birdsfoot trefoil. Two cycles of selection for glyphosate tolerance were practiced in three birdsfoot trefoil populations, Leo, Norcen, and MU-81

  11. Rapid and targeted introgression of genes into popular wheat cultivars using marker-assisted background selection.

    Directory of Open Access Journals (Sweden)

    Harpinder S Randhawa

    Full Text Available A marker-assisted background selection (MABS-based gene introgression approach in wheat (Triticum aestivum L. was optimized, where 97% or more of a recurrent parent genome (RPG can be recovered in just two backcross (BC generations. A four-step MABS method was developed based on 'Plabsim' computer simulations and wheat genome structure information. During empirical optimization of this method, double recombinants around the target gene were selected in a step-wise fashion during the two BC cycles followed by selection for recurrent parent genotype on non-carrier chromosomes. The average spacing between carrier chromosome markers was <4 cM. For non-carrier chromosome markers that flanked each of the 48 wheat gene-rich regions, this distance was approximately 12 cM. Employed to introgress seedling stripe rust (Puccinia striiformis f. sp. tritici resistance gene Yr15 into the spring wheat cultivar 'Zak', marker analysis of 2,187 backcross-derived progeny resulted in the recovery of a BC(2F(2ratio3 plant with 97% of the recurrent parent genome. In contrast, only 82% of the recurrent parent genome was recovered in phenotypically selected BC(4F(7 plants developed without MABS. Field evaluation results from 17 locations indicated that the MABS-derived line was either equal or superior to the recurrent parent for the tested agronomic characteristics. Based on these results, MABS is recommended as a strategy for rapidly introgressing a targeted gene into a wheat genotype in just two backcross generations while recovering 97% or more of the recurrent parent genotype.

  12. Genomic selection prediction accuracy in a perennial crop: case study of oil palm (Elaeis guineensis Jacq.).

    Science.gov (United States)

    Cros, David; Denis, Marie; Sánchez, Leopoldo; Cochard, Benoit; Flori, Albert; Durand-Gasselin, Tristan; Nouy, Bruno; Omoré, Alphonse; Pomiès, Virginie; Riou, Virginie; Suryana, Edyana; Bouvet, Jean-Marc

    2015-03-01

    Genomic selection empirically appeared valuable for reciprocal recurrent selection in oil palm as it could account for family effects and Mendelian sampling terms, despite small populations and low marker density. Genomic selection (GS) can increase the genetic gain in plants. In perennial crops, this is expected mainly through shortened breeding cycles and increased selection intensity, which requires sufficient GS accuracy in selection candidates, despite often small training populations. Our objective was to obtain the first empirical estimate of GS accuracy in oil palm (Elaeis guineensis), the major world oil crop. We used two parental populations involved in conventional reciprocal recurrent selection (Deli and Group B) with 131 individuals each, genotyped with 265 SSR. We estimated within-population GS accuracies when predicting breeding values of non-progeny-tested individuals for eight yield traits. We used three methods to sample training sets and five statistical methods to estimate genomic breeding values. The results showed that GS could account for family effects and Mendelian sampling terms in Group B but only for family effects in Deli. Presumably, this difference between populations originated from their contrasting breeding history. The GS accuracy ranged from -0.41 to 0.94 and was positively correlated with the relationship between training and test sets. Training sets optimized with the so-called CDmean criterion gave the highest accuracies, ranging from 0.49 (pulp to fruit ratio in Group B) to 0.94 (fruit weight in Group B). The statistical methods did not affect the accuracy. Finally, Group B could be preselected for progeny tests by applying GS to key yield traits, therefore increasing the selection intensity. Our results should be valuable for breeding programs with small populations, long breeding cycles, or reduced effective size.

  13. All eggs are not equal: the maternal environment affects progeny reproduction and developmental fate in Caenorhabditis elegans.

    Directory of Open Access Journals (Sweden)

    Simon C Harvey

    Full Text Available Maternal effects on progeny traits are common and these can profoundly alter progeny life history. Maternal effects can be adaptive, representing attempts to appropriately match offspring phenotype to the expected environment and are often mediated via trade-offs between progeny number and quality. Here we have investigated the effect of maternal food availability on progeny life history in the free-living nematode Caenorhabditis elegans.The maternal environment affects both reproductive traits and progeny development. Comparisons of the progeny of worms from high and low maternal food environments indicates that low maternal food availability reduces progeny reproduction in good environments, increases progeny reproduction in poor environments and decreases the likelihood that progeny will develop as dauer larvae. These analyses also indicate that the effects on progeny are not a simple consequence of changes in maternal body size, but are associated with an increase in the size of eggs produced by worms at low maternal food availabilities.These results indicate that the maternal environment affects both progeny reproduction and development in C. elegans and therefore that all progeny are not equal. The observed effects are consistent with changes to egg provisioning, which are beneficial in harsh environments, and of changes to progeny development, which are beneficial in harsh environments and detrimental in benign environments. These changes in progeny life history suggest that mothers in poor quality environments may be producing larger eggs that are better suited to poor conditions.

  14. Live animal measurements, carcass composition and plasma hormone and metabolite concentrations in male progeny of sires differing in genetic merit for beef production.

    Science.gov (United States)

    Clarke, A M; Drennan, M J; McGee, M; Kenny, D A; Evans, R D; Berry, D P

    2009-07-01

    In genetic improvement programmes for beef cattle, the effect of selecting for a given trait or index on other economically important traits, or their predictors, must be quantified to ensure no deleterious consequential effects go unnoticed. The objective was to compare live animal measurements, carcass composition and plasma hormone and metabolite concentrations of male progeny of sires selected on an economic index in Ireland. This beef carcass index (BCI) is expressed in euros and based on weaning weight, feed intake, carcass weight and carcass conformation and fat scores. The index is used to aid in the genetic comparison of animals for the expected profitability of their progeny at slaughter. A total of 107 progeny from beef sires of high (n = 11) or low (n = 11) genetic merit for the BCI were compared in either a bull (slaughtered at 16 months of age) or steer (slaughtered at 24 months of age) production system, following purchase after weaning (8 months of age) from commercial beef herds. Data were analysed as a 2 × 2 factorial design (two levels of genetic merit by two production systems). Progeny of high BCI sires had heavier carcasses, greater (P animal value (obtained by multiplying carcass weight by carcass value, which was based on the weight of meat in each cut by its commercial value) than progeny of low BCI sires. Regression of progeny performance on sire genetic merit was also undertaken across the entire data set. In steers, the effect of BCI on carcass meat proportion, calculated carcass value (c/kg) and animal value was positive (P carcass fat proportion (P carcass weight followed the same trends as BCI. Muscularity scores, carcass meat proportion and calculated carcass value increased, whereas scanned fat depth, carcass fat and bone proportions decreased with increasing sire EPD for conformation score. The opposite association was observed for sire EPD for fat score. Results from this study show that selection using the BCI had positive

  15. Unattached fraction of radon progeny in Polish coal mines

    International Nuclear Information System (INIS)

    Skubacz, K.; Michalik, B.

    2002-01-01

    The system of the monitoring of the radiation hazard in Polish coal mines is based on the monitoring of the workplaces. This system works since 1989 in all coal mines. It gives a very good basis for further epidemiological investigation and assessment of the health detriment within the population of the mines as a result of the exposure for natural radiation. It is very important problem, due to the fact of the presence in the mines another factors, which probably have a synergetic effects on the respiratory tracts. As the routine instrument, a device called ALFA-31 sampling probe was developed in our laboratory. This device was accomplished to regular dust sampler and simultaneous measurements of dust content and potential alpha energy concentration of radon progeny are obligatory in all underground mines in Poland. But the microcyclone used a separator of the respirable fraction which causes the cut-off of unattached fraction of radon progeny, On the other hand measurements of the unattached fraction of short lived radon progeny play a very important role in the investigations of the adequate dose from this source of radiation hazard. During field experiments the use of the alpha spectroscopy system is necessary, while measurements are done not in the vacuum chambers but under normal pressure. It leads to situation, when particular peaks in alpha spectrum are very wide and interfere with other peaks of another alpha-emitting radionuclides. Such instrumentation was designed and completed, and a survey in several underground mines was performed. The analysis of the obtained results must be done very carefully; in other case it may cause a very big uncertainty of the result. In this paper a new approach to the analysis of the alpha spectra has been described. This approach can be used also in other applications of alpha spectroscopy, in which the analysis of energy of alpha peaks in spectrum is needed. The method of the analysis is based on a non-linear regression

  16. An Alpha spectrometer for measuring radon daughter individual activity concentration; Spettrometro Alfa per la misura delle concentrazioni individuali in attivita' della progenie del radon

    Energy Technology Data Exchange (ETDEWEB)

    Berico, M.; Formignani, M. [ENEA, Div. Protezione dell' Uomo e degli Ecosistemi, Centro Ricerche E. Clementel, Bologna (Italy); Mariotti, F. [Bologna Univ., Bologna (Italy). Dipt. di Fisica

    2001-07-01

    In the frame of the program of the Institute for Radiation Protection of ENEA, related to the evaluation of dose from radon and thoron progeny, an alpha spectrometer for the continuous air monitoring (CAM type) of radon and thoron has been realized. The constructive characteristics of the device are here presented together with energy and efficiency calibration. The device allows, by means of a screen type diffusion battery and a filter, to determinate the single radioactivity of each radionuclide of the progeny selecting them in relation to their diffusive behaviour (dichotomous particle size selection). The three-count filter method has been employed to measure the concentrations of {sup 218}Po, {sup 214}Pb and {sup 214}Bi in air. Radon and thoron effective doses using a dosimetric, instead of an epidemiologic approach, will be then evaluated. [Italian] Presso l'Istituto per la Radioprotezione, nell'ambito del programma di valutazione di dose da radon e' stato progettato e realizzato uno spettrometro alfa per il monitoraggio continuo in aria (CAM) della progenie del radon e del toron. Le caratteristiche costruttive dello strumento permettono, tramite l'utilizzo di batterie a diffusione a reti, di determinare l'attivita' individuale della progenie per diverse dimensioni granulometriche in particolare per la frazione attaccata e non al particolato amosferico con un taglio granulometrico di qualche nanometro. E' stato inoltre applicato un metodo spettrometrico a tre conteggi per il calcolo delle concentrazioni individuali della progenie del radon, {sup 218}Po, {sup 214}Pb and {sup 214}Bi, effettuando un conteggio alfa di {sup 218}Po e due conteggi alfa di {sup 214}Po. Tale informazione consentira' una valutazione della dose di radon utilizzando il modello dosimetrico in alternativa a quello epidemiologico.

  17. Differential gene expression of wheat progeny with contrasting levels of transpiration efficiency.

    Science.gov (United States)

    Xue, Gang-Ping; McIntyre, C Lynne; Chapman, Scott; Bower, Neil I; Way, Heather; Reverter, Antonio; Clarke, Bryan; Shorter, Ray

    2006-08-01

    High water use efficiency or transpiration efficiency (TE) in wheat is a desirable physiological trait for increasing grain yield under water-limited environments. The identification of genes associated with this trait would facilitate the selection for genotypes with higher TE using molecular markers. We performed an expression profiling (microarray) analysis of approximately 16,000 unique wheat ESTs to identify genes that were differentially expressed between wheat progeny lines with contrasting TE levels from a cross between Quarrion (high TE) and Genaro 81 (low TE). We also conducted a second microarray analysis to identify genes responsive to drought stress in wheat leaves. Ninety-three genes that were differentially expressed between high and low TE progeny lines were identified. One fifth of these genes were markedly responsive to drought stress. Several potential growth-related regulatory genes, which were down-regulated by drought, were expressed at a higher level in the high TE lines than the low TE lines and are potentially associated with a biomass production component of the Quarrion-derived high TE trait. Eighteen of the TE differentially expressed genes were further analysed using quantitative RT-PCR on a separate set of plant samples from those used for microarray analysis. The expression levels of 11 of the 18 genes were positively correlated with the high TE trait, measured as carbon isotope discrimination (Delta(13)C). These data indicate that some of these TE differentially expressed genes are candidates for investigating processes that underlie the high TE trait or for use as expression quantitative trait loci (eQTLs) for TE.

  18. Portable devices for monitoring radon and its progeny in air

    International Nuclear Information System (INIS)

    Zhang Huaiqin; Yao Wanyuan; Su Jingling; Liu Jinhua

    1990-01-01

    We have developed two kinds of portable monitoring devices to measure the concentration and potential energy concentration of radon and its progeny in air. The thermoluminescence material CaSO4 (Tm) is used as the detection element. One of the devices is called passive radon monitor. The lowest detectable limit for radon in air is about 1.5 Bq/m 3 , as a sampling time being one week. Good reliability and ease to operate are its main advantages. The second kind of device is called a working level monitor which consists of a miniature remembrane pump and an integrating sampling probe. The lowest detectable limit is about 0.00043 WL (9x10 -9 J/m 3 ) for a sampling time of 6 hours. It weighs only 0.35 kg, but maintenance is necessary sometimes. (author). 6 refs, 2 figs, 4 tabs

  19. Control of respirable particles and radon progeny with portable air cleaners

    International Nuclear Information System (INIS)

    Offermann, F.J.; Sextro, R.G.; Fisk, W.J.; Nazaroff, W.W.; Nero, A.V.; Revzan, K.L.; Yater, J.

    1984-02-01

    Eleven portable air cleaning devices have been evaluated for control of indoor concentrations of respirable particles and radon progeny. Following injection of cigarette smoke and radon in a room-size chamber, decay rates for particles and radon progeny concentrations were measured with and without air cleaner operation. Particle concentrations were obtained for total number concentration and for number concentration by particle size. In tests with no air cleaner the natural decay rate for cigarette smoke was observed to be 0.2 hr -1 . Air cleaning rates for particles were found to be negligible for several small panel-filters, a residential ion-generator, and a pair of mixing fans. The electrostatic precipitators and extended surface filters tested had significant particle removal rates, and a HEPA-type filter was the most efficient air cleaner. The evaluation of radon progeny control produced similar results; the air cleaners which were effective in removing particles were also effective in removing radon progeny. At low particle concentrations plateout of the unattached radon progeny is an important removal mechanism. Based on data from these tests, the plateout rate for unattached progeny was found to be 15 hr -1 . The unattached fraction and the overall removal rate due to deposition of attached and unattached nuclides have been estimated for each radon decay product as a function of particle concentration. While air cleaning can be effective in reducing total radon progeny, concentrations of unattached radon progeny can increase with increasing air cleaning. 39 references, 26 figures, 9 tables

  20. Evaluation of indoor aerosol control devices and their effects on radon progeny concentrations. Revision

    International Nuclear Information System (INIS)

    Sextro, R.G.; Offermann, F.J.; Nazaroff, W.W.; Nero, A.V.; Revzan, K.L.; Yater, J.

    1984-11-01

    Eleven portable air cleaning devices have been evaluated for control of indoor concentrations of respirable particles, and their concomitant effects on radon progeny concentrations have been investigated. The experiments were conducted in a room-size chamber using cigarette smoke and radon injection from an external source. Of the devices examined the electrostatic precipitators and extended surface filters had significant particle removal rates, while the particle removal rates for several small panel-filters, an ion-generator, and a pair of mixing fans were found to be essentially negligible. The evaluation of radon progeny control produced similar results; the air cleaners which were effective in removing particles were also effective in reducing radon progeny concentrations. At the low particle concentrations, deposition of the unattached radon progeny on room surfaces was found to be a significant removal mechanism. Deposition rates of attached and unattached progeny have been estimated from these data, and were used to calculate the equilibrium factors for total and unattached progeny concentrations as a function of particle concentration. While particle removal reduces total airborne radon progeny concentrations, the relative alpha decay dose to the lungs appears to change very little as the particle concentration decreases due to the greater radiological importance of unattached progeny

  1. RADON PROGENY AS AN EXPERIMENTAL TOOL FOR DOSIMETRY OF NANOAEROSOLS

    Energy Technology Data Exchange (ETDEWEB)

    Ruzer, Lev; Ruzer, Lev S.; Apte, Michael G.

    2008-02-25

    The study of aerosol exposure and dosimetry measurements and related quantitation of health effects are important to the understanding of the consequences of air pollution, and are discussed widely in the scientific literature. During the last 10 years the need to correlate aerosol exposure and biological effects has become especially important due to rapid development of a new, revolutionary industry ?-- nanotechnology. Nanoproduct commerce is predicted to top $1 trillion by 2015. Quantitative assessment of aerosol particle behavior in air and in lung deposition, and dosimetry in different parts of the lung, particularly for nanoaerosols, remains poor despite several decades of study. Direct measurements on humans are still needed in order to validate the hollow cast, animal studies, and lung deposition modeling. We discuss here the use of nanoscale radon decay products as an experimental tool in the study of local deposition and lung dosimetry for nanoaerosols. The issue of the safe use of radon progeny in such measurements is discussed based on a comparison of measured exposure in 3 settings: general population, miners, and in a human experiment conducted at the Paul Scherer Institute (PSI) in Switzerland. One of the properties of radon progeny is that they consist partly of 1 nm radioactive particles called unattached activity; having extremely small size and high diffusion coefficients, these particles can be potentially useful as radioactive tracers in the study of nanometer-sized aerosols. We present a theoretical and experimental study of the correlation between the unattached activity and aerosol particle surface area, together with a description of its calibration and method for measurement of the unattached fraction.

  2. Diurnal variations of indoor radon progeny for Bangalore metropolitan, India

    International Nuclear Information System (INIS)

    Nagesh, V.; Sathish, L.A.; Nagaraja, K.; Sundareshan, S.

    2010-01-01

    Radon progenies are identified as major causes of the lung cancer if the activity is above its normal. It has not been clear whether radon poses a similar risk of causing lung cancer in humans exposed at generally lower levels found in homes, but a number of indoor radon survey have been carried out in recent years around the world. In view of this an attempt has been made for the measurement of diurnal variation of indoor radon levels for the environment of Bangalore metropolitan, India. The Radon progeny concentrations in terms of working level were measured using Kusnetz's method. The patterns of daily and annual changes in indoor Radon concentration have been observed in a general way for many years. However, understanding of the physical basis for these changes had to await the development of continuous monitors and a more complete knowledge of transport processes in the atmosphere. Over a continent, heating of the ground surface by the Sun during the day and cooling by radiation during the night causes a marked diurnal change in temperature near the surface. As a result cool air near the ground will accumulate radon isotopes from surface flux during the night; while during the day the warm air will be transported upward carrying radon with it. Many buildings show diurnal radon variations. Concentrations are relatively higher during night than daytime. This is influenced by the outdoor-indoor temperature contrast. This effect can be enhanced in buildings with strong diurnal use patterns. Buildings that have high average radon concentrations, but are only occupied for part of the day, may need to be measured during occupied periods to determine if there is significant diurnal radon variation. The results are discussed in detail. (author)

  3. Errata :Chromosomal Abnormalities in Couples with Recurrent ...

    African Journals Online (AJOL)

    Chromosomal Abnormalities in Couples with Recurrent Abortions in Lagos, Nigeria. Akinde OR, Daramola A O, Taiwo I A, Afolayan M O and Akinsola Af. Sonographic Mammary Gland Density Pattern in Women in Selected ommunities of Southern Nigeria.

  4. Recurrent Novae — A Review

    Directory of Open Access Journals (Sweden)

    K. Mukai

    2015-02-01

    Full Text Available In recent years, recurrent nova eruptions are often observed very intensely in wide range of wavelengths from radio to optical to X-rays. Here I present selected highlights from recent multi-wavelength observations. The enigma of T Pyx is at the heart of this paper. While our current understanding of CV and symbiotic star evolution can explain why certain subset of recurrent novae have high accretion rate, that of T Pyx must be greatly elevated compared to the evolutionary mean. At the same time, we have extensive data to be able to estimate how the nova envelope was ejected in T Pyx, and it turns to be a rather complex tale. One suspects that envelope ejection in recurrent and classical novae in general is more complicated than the textbook descriptions. At the end of the review, I will speculate that these two may be connected.

  5. An overview of thoron and its progeny in the indoor environment

    International Nuclear Information System (INIS)

    McLaughlin, J.

    2010-01-01

    An account is given of the behaviour of thoron and its progeny in the indoor environment. Emphasis is placed on the spatial distribution of these radionuclides in room air and on their interactions with indoor aerosols. How these aspects of thoron and progeny behaviour give rise to special problems for measuring them and assessing their radiological impact are described. Descriptions and comparisons are given of a range of thoron and progeny measurement techniques both passive and active. Recent progress in thoron dosimetry is described as well as compared with radon dosimetry. The results of some indoor thoron and progeny surveys carried out in different countries in recent years are given. As an example of this a summary account is presented of a recently concluded survey of thoron and its airborne progeny in over 200 houses in Ireland. (authors)

  6. Seleção para aumento de produtividade e qualidade de frutos em abobrinha 'Piramoita' comparando dois métodos de melhoramento Selection for fruit yield and quality in 'Piramoita' summer squash comparing two breeding methods

    Directory of Open Access Journals (Sweden)

    Antonio Ismael Inácio Cardoso

    2007-01-01

    Full Text Available Este trabalho teve por objetivo comparar dois métodos de melhoramento quanto à seleção visando ao aumento de produtividade e qualidade de frutos na cv. Piramoita. Foram realizados três ciclos de seleção recorrente, com seleção de progênies autofecundadas (S1 e recombinação das melhores progênies para obtenção das populações melhoradas no primeiro (SR-1, segundo (SR-2 e terceiro (SR-3 ciclos. No método do "Single Seed Descent" (SSD as plantas foram autofecundadas por cinco gerações até a obtenção e avaliação de progênies S5. As nove melhores progênies foram selecionadas obtendo-se progênies endogâmicas selecionadas (SSD-1 a SSD-9 e essas progênies também foram intercruzadas para se obter a população P-SSD. Todas as populações obtidas (SR-1, SR-2, SR-3, P-SSD, SSD-1 a SSD-9, juntamente com a população original (cv. Piramoita, totalizando 14 tratamentos, foram avaliadas em um experimento em blocos ao acaso, com seis repetições e cinco plantas por parcela. As características avaliadas foram: produção de frutos (número e massa total e comercial, massa média de fruto comercial e taxa de frutos comerciais. Foram obtidos aumentos crescentes de produção de frutos comerciais com os ciclos de seleção recorrente, sendo a população SR-3 superior à 'Piramoita' para número de frutos por planta. Foi obtida uma progênie por SSD melhor que a população inicial e tão produtiva quanto à população SR-3. Deste modo, o método SSD pode vir a ser ótima alternativa no melhoramento genético de abobrinha, sem a necessidade de avaliação e seleção de progênies a cada safra, apenas quando essas já estiverem praticamente homozigotas.The objective of this work was to compare two breeding methods to improve fruit yield and quality in 'Piramoita' summer squash. Three cycles of recurrent selection were made, with evaluation and selection of S1 progenies and recombination of plants from selected progenies to obtain

  7. Selecting breast cancer patients with T1-T2 tumors and one to three positive axillary nodes at high postmastectomy locoregional recurrence risk for adjuvant radiotherapy

    International Nuclear Information System (INIS)

    Truong, Pauline T.; Olivotto, Ivo A.; Kader, Hosam A.; Panades, Miguel; Speers, Caroline H.; Berthelet, Eric

    2005-01-01

    Purpose: To define the individual factors and combinations of factors associated with increased risk of locoregional recurrence (LRR) that may justify postmastectomy radiotherapy (PMRT) in patients with T1-T2 breast cancer and one to three positive nodes. Methods and Materials: The study cohort comprised 821 women referred to the British Columbia Cancer Agency between 1989 and 1997 with pathologic T1-T2 breast cancer and one to three positive nodes treated with mastectomy without adjuvant RT. The 10-year Kaplan-Meier estimates of isolated LRR and LRR with or without simultaneous distant recurrence (LRR ± SDR) were analyzed according to age, histologic findings, tumor location, size, and grade, lymphovascular invasion status, estrogen receptor (ER) status, margin status, number of positive nodes, number of nodes removed, percentage of positive nodes, and systemic therapy use. Multivariate analyses were performed using Cox proportional hazards modeling. A risk classification model was developed using combinations of the statistically significant factors identified on multivariate analysis. Results: The median follow-up was 7.7 years. Systemic therapy was used in 94% of patients. Overall, the 10-year Kaplan-Meier isolated LRR and LRR ± SDR rate was 12.7% and 15.9%, respectively. Without PMRT, a 10-year LRR risk of >20% was identified in women with one to three positive nodes plus at least one of the following factors: age 25% of nodes positive (all p 25% of nodes positive, medial tumor location, and ER-negative status were statistically significant predictors of isolated LRR and LRR ± SDR. In the classification model, the first split was according to age ( 25% of nodes positive was associated with a risk of LRR ± SDR of 58.0% compared with 23.8% for those with ≤25% of nodes positive (p = 0.01). Of 698 women >45 years, the presence of >25% of nodes positive also conferred a greater LRR ± SDR risk (26.7%) compared with women with ≤25% of nodes positive (10

  8. A score system for complete cytoreduction in selected recurrent ovarian cancer patients undergoing secondary cytoreductive surgery: predictors- and nomogram-based analyses.

    Science.gov (United States)

    Bogani, Giorgio; Tagliabue, Elena; Signorelli, Mauro; Ditto, Antonino; Martinelli, Fabio; Chiappa, Valentina; Mosca, Lavinia; Sabatucci, Ilaria; Leone Roberti Maggiore, Umberto; Lorusso, Domenica; Raspagliesi, Francesco

    2018-05-01

    To test the applicability of the Arbeitsgemeinschaft Gynäkologische Onkologie (AGO) and Memorial Sloan Kettering (MSK) criteria in predicting complete cytoreduction (CC) in patients undergoing secondary cytoreductive surgery (SCS) for recurrent ovarian cancer (ROC). Data of consecutive patients undergoing SCS were reviewed. The Arbeitsgemeinschaft Gynäkologische Onkologie OVARian cancer study group (AGO-OVAR) and MSK criteria were retrospectively applied. Nomograms, based on AGO criteria, MSK criteria and both AGO and MSK criteria were built in order to assess the probability to achieve CC at SCS. Overall, 194 patients met the inclusion criteria. CC was achieved in 161 (82.9%) patients. According to the AGO-OVAR criteria, we observed that CC was achieved in 87.0% of patients with positive AGO score. However, 45 out of 71 (63.4%) patients who did not fulfilled the AGO score had CC. Similarly, CC was achieved in 87.1%, 61.9% and 66.7% of patients for whom SCS was recommended, had to be considered and was not recommended, respectively. In order to evaluate the predictive value of the AGO-OVAR and MSK criteria we built 2 separate nomograms (c-index: 0.5900 and 0.5989, respectively) to test the probability to achieve CC at SCS. Additionally, we built a nomogram using both the aforementioned criteria (c-index: 0.5857). The AGO and MSK criteria help identifying patients deserving SCS. However, these criteria might be strict, thus prohibiting a beneficial treatment in patients who do not met these criteria. Further studies are needed to clarify factors predicting CC at SCS. Copyright © 2018. Asian Society of Gynecologic Oncology, Korean Society of Gynecologic Oncology.

  9. Levels of thoron and progeny in high background radiation area of southeastern coast of Odisha (India))

    International Nuclear Information System (INIS)

    Ramola, R. C.; Gusain, G. S.; Rautela, B. S.; Sagar, D. V.; Prasad, G.; Shahoo, S. K.; Ishikawa, T.; Omori, Y.; Janik, M.; Sorimachi, A.; Tokonami, S.

    2012-01-01

    Exposure to radon, 222 Rn, is assumed to be the most significant source of natural radiation to human beings in most cases. It is thought that radon and its progeny are major factors that cause cancer. The presence of thoron, 220 Rn, was often neglected because it was considered that the quantity of thoron in the environment is less than that of radon. However, recent studies have shown that a high thoron concentration was found in some regions and the exposure to 220 Rn and its progeny can equal or several time exceed that of 220 Rn and its progeny. The results of thoron and its progeny measurements in the houses of high background radiation area (HBRA) of the southeastern coast of Odisha (India)) presented here. This area is one of the high background radiation areas in India with a large deposit of monazite sand which is the probable source of thoron. Both active and passive methods were employed for the measurement of thoron and its progeny in cement, brick and mud houses in the study area. Thoron concentration was measured using RAD-7 and Raduet. A CR-39 track detector was employed for the measurement of environmental thoron progeny, both in active and passive modes. Thoron and its progeny concentrations were found to be comparatively high in the area. A comparison between the results obtained with various techniques is presented in this paper. (authors)

  10. Levels of thoron and progeny in high background radiation area of southeastern coast of Odisha (India))

    Energy Technology Data Exchange (ETDEWEB)

    Ramola, R C; Gusain, G S; Rautela, B S [Dept. of Physics, H.N.B. Garhwal Univ., Badshahi Thaul Campus, Tehri Garhwal 249199 (India); Sagar, D V [Health Physics Unit EAD, BARC, IRE, OSCOM, Matikhalo, Ganjam, Odisha 761 045 (India); Prasad, G; Shahoo, S K; Ishikawa, T; Omori, Y; Janik, M [National Inst. of Radiological Sciences, Anagawa 4-9-1, Inage-ku, Chiba 263-8555 (Japan); Sorimachi, A; Tokonami, S [Inst. of Radiation Emergency Medicine, Hirosaki Univ., Aomori 036-8564 (Japan)

    2012-07-01

    Exposure to radon, {sup 222}Rn, is assumed to be the most significant source of natural radiation to human beings in most cases. It is thought that radon and its progeny are major factors that cause cancer. The presence of thoron, {sup 220}Rn, was often neglected because it was considered that the quantity of thoron in the environment is less than that of radon. However, recent studies have shown that a high thoron concentration was found in some regions and the exposure to {sup 220}Rn and its progeny can equal or several time exceed that of {sup 220}Rn and its progeny. The results of thoron and its progeny measurements in the houses of high background radiation area (HBRA) of the southeastern coast of Odisha (India)) presented here. This area is one of the high background radiation areas in India with a large deposit of monazite sand which is the probable source of thoron. Both active and passive methods were employed for the measurement of thoron and its progeny in cement, brick and mud houses in the study area. Thoron concentration was measured using RAD-7 and Raduet. A CR-39 track detector was employed for the measurement of environmental thoron progeny, both in active and passive modes. Thoron and its progeny concentrations were found to be comparatively high in the area. A comparison between the results obtained with various techniques is presented in this paper. (authors)

  11. Deposition Pattern of Inhaled Thoron Progeny Size Distribution in Human Lung

    International Nuclear Information System (INIS)

    Mohamed, A.

    2005-01-01

    One of the important factors controlling the distribution of radiation dose to the different portions of the human respiratory tract is the deposition pattern of thoron progeny containing aerosol. Based on the activity size distribution parameters of thoron progeny, which were measured in El-Minia University, the deposition behavior of thoron progeny (attached and unattached) has been studied by using a stochastic deposition model. The measurements were performed with a wire screen diffusion battery and a low pressure cascade impactor (type Berner). The bronchial deposition efficiencies of particles in the size range of attached thoron progeny were found to be lower than those of unattached progeny. The effect of thoron progeny deposition by adult male has been also studied for various levels of physical exertion. An increase in the breathing rate was found to decrease the efficiencies with which inhaled progeny were deposited in the bronchi. As the ventilation rate increases from 0.54 to 1.5 m3 h-1, the average deposition efficiencies of airway generation 1 through 8 are expected to decrease by 22 % for 1.4 nm particles and by 38 % for 150 nm particles

  12. Study on radon and thoron progeny levels in Gudalore in South India

    International Nuclear Information System (INIS)

    Selvasekarapandian, S.; Sivakumar, R.; Mugunthamanikandan, N.; Meenakshisundaram, V.; Santhanam, R.

    2000-01-01

    One of the important route of radiation exposure to man is through inhalation of air containing radioisotopes. A major contribution to inhalation dose comes from radon, thoron and its progenies. The indoor radon and thoron progeny levels are determined by two count method. In this method the radon and thoron progenies are collected on a glass fiber filter paper using volume air sampler (Staplex) and counted for alpha activity in ZnS (Ag) alpha counting system. It is observed that thoron working level is higher than the radon working level in all houses except few houses with stone walls and mosaic floor. Behavior of indoor radon and thoron working levels for different seasons at different houses are determined and discussed in detail. Radon and thoron working levels are measured high in winter, autumn, and low in summer and rainy seasons. Among all seasons highest value is measured in winter and low in summer and rainy seasons. Radon progeny working level varies from 1.659 to 6.675 mWL, whereas thoron progeny working level varies from 1.670 to 12.671 mWL. The geometric mean values of radon and thoron progeny concentration in the present study are 2.836 and 4.133 mWL. The high thoron progeny level observed in this is attributed to the high thorium content observed in soils of this area. (author)

  13. Event dependent sampling of recurrent events

    DEFF Research Database (Denmark)

    Kvist, Tine Kajsa; Andersen, Per Kragh; Angst, Jules

    2010-01-01

    The effect of event-dependent sampling of processes consisting of recurrent events is investigated when analyzing whether the risk of recurrence increases with event count. We study the situation where processes are selected for study if an event occurs in a certain selection interval. Motivation...... retrospective and prospective disease course histories are used. We examine two methods to correct for the selection depending on which data are used in the analysis. In the first case, the conditional distribution of the process given the pre-selection history is determined. In the second case, an inverse...

  14. Maternal Diet and Insulin-Like Signaling Control Intergenerational Plasticity of Progeny Size and Starvation Resistance.

    Directory of Open Access Journals (Sweden)

    Jonathan D Hibshman

    2016-10-01

    Full Text Available Maternal effects of environmental conditions produce intergenerational phenotypic plasticity. Adaptive value of these effects depends on appropriate anticipation of environmental conditions in the next generation, and mismatch between conditions may contribute to disease. However, regulation of intergenerational plasticity is poorly understood. Dietary restriction (DR delays aging but maternal effects have not been investigated. We demonstrate maternal effects of DR in the roundworm C. elegans. Worms cultured in DR produce fewer but larger progeny. Nutrient availability is assessed in late larvae and young adults, rather than affecting a set point in young larvae, and maternal age independently affects progeny size. Reduced signaling through the insulin-like receptor daf-2/InsR in the maternal soma causes constitutively large progeny, and its effector daf-16/FoxO is required for this effect. nhr-49/Hnf4, pha-4/FoxA, and skn-1/Nrf also regulate progeny-size plasticity. Genetic analysis suggests that insulin-like signaling controls progeny size in part through regulation of nhr-49/Hnf4, and that pha-4/FoxA and skn-1/Nrf function in parallel to insulin-like signaling and nhr-49/Hnf4. Furthermore, progeny of DR worms are buffered from adverse consequences of early-larval starvation, growing faster and producing more offspring than progeny of worms fed ad libitum. These results suggest a fitness advantage when mothers and their progeny experience nutrient stress, compared to an environmental mismatch where only progeny are stressed. This work reveals maternal provisioning as an organismal response to DR, demonstrates potentially adaptive intergenerational phenotypic plasticity, and identifies conserved pathways mediating these effects.

  15. Multi-parametric approach towards the assessment of radon and thoron progeny exposures

    Energy Technology Data Exchange (ETDEWEB)

    Mishra, Rosaline, E-mail: rosaline@barc.gov.in, E-mail: rosaline.mishra@gmail.com; Sapra, B. K. [Radiological Physics and Advisory Division, Bhabha Atomic Research Centre, Mumbai 400 085 (India); Mayya, Y. S. [Indian Institute of Technology, Mumbai (India)

    2014-02-15

    Conventionally, the dosimetry is carried out using radon and thoron gas concentration measurements and doses have been assigned using assumed equilibrium factors for the progeny species, which is inadequate pertaining to the variations in equilibrium factors and possibly due to significant thoron. In fact, since the true exposures depend upon the intricate mechanisms of progeny deposition in the lung, therefore an integrated approach for the assessment of progeny is essential. In this context, the recently developed deposition based progeny concentration measurement techniques (DTPS: Direct Thoron progeny sensors and DRPS: Direct Radon progeny sensors) appear to be best suited for radiological risk assessments both among occupational workers and general study populations. DTPS and DRPS consist of aluminized mylar mounted LR115 type passive detectors, which essentially detects the alpha particles emitted from the deposited progeny atoms on the detector surface. It gives direct measure of progeny activity concentrations in air. DTPS has a lower limit of detection limit of 0.1 Bq/m{sup 3} whereas that for DRPS is 1 Bq/m{sup 3}, hence are perfectly suitable for indoor environments. These DTPS and DRPS can be capped with 200-mesh type wire-screen to measure the coarse fraction of the progeny concentration and the corresponding coarse fraction deposition velocities as well as the time integrated fine fraction. DTPS and DRPS can also be lodged in an integrated sampler wherein the wire-mesh and filter-paper are arranged in an array in flow-mode, to measure the fine and coarse fraction concentration separately and simultaneously. The details are further discussed in the paper.

  16. Radon and radon progeny in 70 houses in the Tennessee Valley area: study design and measurement methods

    International Nuclear Information System (INIS)

    Dudney, C.S.; Hawthorne, A.R.; Monar, K.P.; Quillen, J.L.; Clark, C. Jr.; Doane, R.W.; Wallace, R.G.; Reed, R.P.

    1986-01-01

    Levels of radon and its short-lived airborne progeny are being measured in a year-long study of 70 houses in four states in the Tennessee Valley. Various methods were used to solicit volunteers with differing degrees of success. Criteria for selection of houses in the study included presence of a lower level with cement floor and one or more block walls in contact with the soil, absence of obvious indications of technologically enhanced sources of radium, and proximity to one of four cities, (Knoxville, Chattanooga, Birmingham, or Florence). By design, most houses in the study are in the same neighborhood as at least one other house in the study. Houses range in age from newly constructed to about 40 years old. Most of the houses have more than 2000 square feet of finished floor space. The lower level encompasses a garage in most cases. More complete information pertaining to house characteristics will be gathered in the course of the study. Measurements are being made to obtain information on both location- and season-dependent variation of radon and radon progeny. Simultaneous measurements are made quarterly on both upper and lower levels of each house. Grab samples of air are collected and analyzed for radon using a modified Lucas cell technique. Short-term (10-minute) samples of airborne particulate material are collected and analyzed for radon progeny. One-week integrated measurements of working levels are made once each quarter using modified thermoluminescent dosimeters. Both three- and twelve-month integrated measurements of radon using track-etch monitors are being made. 19 references, 1 figures

  17. Measurement of radon, thoron and their progeny concentrations in the dwellings of Pauri Garhwal, Uttarakhand, India

    International Nuclear Information System (INIS)

    Joshi, Veena; Bijalwan, Pramesh; Rawat, Jasbir; Yadav, Manjulata; Ramola, R.C.; Mishra, Rosaline

    2015-01-01

    It is well known that inhalation of radon, thoron and their progeny contribute more than 50% of natural background radiation dose to human being. The time integrated passive measurements of radon, thoron and their progeny concentrations were carried out in the dwellings of Pauri Garhwal, Uttarakhand, India. The measurements of radon and thoron concentrations were performed by LR-115 detector based single entry Pin-Hole dosimeter while for the measurement of progeny concentrations, LR-115 deposition based DTPS/DRPS technique was used. The experimental techniques and results obtained are discussed in detail. (author)

  18. Optimization of filtration for control of exposure to radon progeny

    International Nuclear Information System (INIS)

    Curling, C.A.; Rudnick, S.N.; Ryan, P.B.; Moeller, D.W.

    1989-01-01

    The theoretical optimization of filter characteristics that minimize an individual's dose from the inhalation of radon progeny is described. The computer simulation presented combines models for a well-mixed room, lung deposition, and lung dose equivalent. A modified form of the Jacobi-Porstendorfer room model and the Jacobi-Eisfeld lung dosimetry model are used for the simulation. The parameters of the filter that are optimized include the filter's solidity, thickness, and fiber diameter. Room ventilation, particle size distribution and concentration, and other factors are specified. The theoretical model is used to determine optimal filter characteristics for reducing the lung dose equivalent under specified room conditions. The resulting optimal design is a thin filter (0.1 - 0.7 mm) of low solidity (0.5 - 1.0%) and relatively large diameter fibers (30 - 100 μm). This model indicates that a significant reduction in the dose-equivalent rate can be achieved through the use of a properly designed recirculating filter system

  19. Analysis of the mortality of the progeny of exposed parents

    International Nuclear Information System (INIS)

    Kosenko, M.M.

    1996-01-01

    The purpose of this study was to analyze the values, time course, and structure of mortality of the progeny of exposed residents of villages on the banks of the Techa river in the Urals. The exposure was caused by discharge of radioactive waste of Mayak radiochemical plant for the manufacture of bomb plutonium into the river. A total of 76x10 6 m 3 liquid waste with a total activity of 2,75x10 6 Ci was discharged into the river from 1949 to 1956. The population of villages on the banks of the river, 26554 subjects was exposed to external and internal radiation. The doses per gonads caused by external exposure and incorporation of evenly distributed radionuclides (mainly 137 Cs) ranged 20 to 1270 mSv. A total of 23869 children were born to exposed subjects since the beginning of exposure; 3160 of these were exposed in utero. The mortality rates int he studied cohort was nothigher than in controls. However, deaths from the so-called endogenous causes were more frequent for the descendants of exposed subjects: neonatal diseases, congenital developmental defects, and states that could not be accurately defined. Correlation of the number of deaths from congenital developmental defects to the collective gonadal dose permitted us to assess the risk as 0.004 perSv, this being in agreement with the estimates of the International Committee for Radiation Protection. 7 refs.; 2 figs.; 6 tabs

  20. Genetic variability of Cordia alliodora (R. and P.) Oken progenies

    International Nuclear Information System (INIS)

    Marulanda, Marta Leonor; Lopez, Ana Maria; Uribe, Marcela; Ospina, Carlos Mario

    2011-01-01

    Cordia alliodora is a well-known wood producer tree of tropical areas of Latin America and the Caribbean characterized for producing valuable wood and by its fast growth rate. In Colombia, it is frequent on agro-forestall systems with coffee. This species, like most forest species have biological problems for genetic improvement programs, such as long regeneration periods and high costs for supporting a population in a long term. The molecular assisted markers in plant breeding programs have had a great impact on genetic improvement, due to the fact they minimize their intervals of regeneration, increase the genetic gain by generation and allow the evaluation of the genetic information essential for the species. In this work, 60 genotypes of C. alliodora were characterized, belonging to the provenance and progenies tests established by the program of genetic improvement of Cenicafe. The characterization was carried out through micro satellite markers, after developing a genomic library enriched with micro satellites of the species. Finally, 24 specific micro satellites were evaluated, 20 of which allowed the detection of 28 polymorphic and multiallelic loci. These results provide a guide for orienting the policies of sustainable production and conservation of this valuable species; also, it provides a useful tool for the identification of clones with commercial interest.

  1. Filtration approach to mitigate indoor Thoron progeny concentration

    International Nuclear Information System (INIS)

    Wang, J.; Meisenberg, O.; Karg, E.; Tschiersch, J.; Chen, Y.

    2010-01-01

    This study investigates filtration of air as potential mitigation method of thoron progeny exposure. The experiments were conducted in a model room (volume 7.1 m 3 ) which was equipped with a pump and an HEPA (high efficiency particulate air) filter. Filtration at a rate of 0.2, 0.4, 0.5 and 0.8 h -1 during 88 h proved an effective practice in reducing the total indoor thoron decay product concentration. The results indicate that 0.4-0.8 h -1 filtration rate had almost the same filtration efficiency in decreasing the total thoron EEC (equilibrium equivalent concentration) by 97% while 80% of total thoron EEC were reduced by 0.2 h -1 filtration rate; meanwhile, the unattached thoron EEC rose significantly by 190, 270, 290%, respectively under 0.4-0.8 h -1 filtration rate, whereas 0.2 h -1 filtration rate increased unattached thoron EEC by 40%. The aerosol number size distribution variation reveals that filtration operation removes smaller particles faster or earlier than the larger ones. The annual effective dose calculated was reduced by 91-92% at a filtration rate of 0.4-0.8 h -1 while 75% reduced at 0.2 h -1 filtration rate after 88 h filtration process. (authors)

  2. Differential diagnosis of recurrent bronchitis in children

    Directory of Open Access Journals (Sweden)

    I. I. Zakirov

    2016-01-01

    Full Text Available The interest of the doctors — pediatricians to recurrent bronchitis is caused by its high specific weight in the structure of bronchopulmonary pathology in children, the complexity and the need to search the differential selection of an individual regimen and prevention. Recurrent bronchitis with bronchoobstructive syndromes patient is regarded as a predictor of asthma, however, erroneously consider these nosological forms as the stages of a single pathophysiological chain as congenital and acquired diseases of respiratory system, pathology of gastro-intestinal tract, cardio-vascular system can masquerade as recurrent bronchitis. The aim of this work — to analyze the current medical literature on the problem of differential search causes leading recurrent respiratory syndrome in children. Materials and methods. The review publications domestic and foreign authors studied data from clinical and epidemiological studies. Results and its discussion. Anatomical physiological characteristics of the respiratory tract, complicated premorbid background, the re-infection of the child respiratory infection contribute to the recurrent course of bronchitis. The most common recurrent bronchitis is transient, recurrent bronchitis episodes completely stoped with the age of the child. Recurrent respiratory infections can fix bronchial hyperreactivity and with the presence of aggravated allergic history lead to the development of asthma. Severe bronchitis, resistance to standard scheme of therapy, the frequent recurrence of respiratory syndrome dictate the need to expand the diagnostic research to clarify the leading cause of recurrent bronchitis. Conclusion. Recurrent bronchitis is considered as a separate nosological form. At the same time, by repeated episodes of respiratory infection may be masked by malformations, hereditary diseases of respiratory system, bronchus foreign body microaspiration syndrome, pathology of the cardio-vascular system. 

  3. Study of radon progeny distribution and radiation dose rate in the atmosphere

    International Nuclear Information System (INIS)

    Fujinami, Naoto

    2009-01-01

    The absorbed dose rate in air of airborne gamma-ray and the concentration of radon progeny in surface air have been observed continuously in Maizuru, Japan. When data observed on fine days were plotted, with dose rate as ordinate and contraction as abscissa, these points traced with a lapse of time illustrated an anticlockwise looping for each day. This result suggests that the variation of absorbed dose rate lags behind that of concentration of radon progeny; this is due to the delay time incurred as the concentration level gradually varies from ground surface to upper air. Radon progeny concentrations in precipitation and in surface air have been observed there in order to study the relationship between the two concentrations and the influence of precipitation patterns on the concentration in precipitation. Results obtained from analysis of the observed data suggest that radon progeny in precipitation originate mainly from scavenging within the cloud (rainout) and not from that below the cloud (washout). (author)

  4. Role of radon and its progeny in the origin and evolution of life on earth

    International Nuclear Information System (INIS)

    Subba Ramu, M.C.; Vohra, K.G.

    1980-01-01

    The role of natural ionising radiations from radon and its progeny in catalysing certain chemical reactions and aiding certain biological phenomena leading to the formation and evolution of life on earth is explained with illustrations. (M.G.B.)

  5. Inherited effects in F1 progeny of partially sterile male phthorimaea operculella (Lepidoptera: Gelechiidae)

    International Nuclear Information System (INIS)

    Makee, H.; Saour, G.

    1998-01-01

    Adult male phthorimaea operculella (Zeller), were exposed to sub sterilizing doses of gamma irradiation: 100, 150 and 200 Gy. Inherited effects in the F 1 , progeny of irradiated male parents were examined. Mean developmental time and the percentage mortality of the F 1 progeny, of each examined dose, were higher than that of the control group. Moreover, the sex ratio of the F 1 , progeny was skewed in favor of the males. Mean longevity, fecundity, and the percentage fertility of the F 1 progeny were lower than those of their parents and the control group. Mating ability and the frequency of mating of F 1 adults were similar to those of their partially sterile male parents and the control. The genetic basis of the F 1 characteristics has been discussed. The use of sub sterilizing doses of irradiation could be considered as an important component in a potato tuber moth control strategy. (author). 17 refs., 3 tabs

  6. Recurrence in affective disorder

    DEFF Research Database (Denmark)

    Kessing, L V; Olsen, E W; Andersen, P K

    1999-01-01

    The risk of recurrence in affective disorder is influenced by the number of prior episodes and by a person's tendency toward recurrence. Newly developed frailty models were used to estimate the effect of the number of episodes on the rate of recurrence, taking into account individual frailty toward...... recurrence. The study base was the Danish psychiatric case register of all hospital admissions for primary affective disorder in Denmark during 1971-1993. A total of 20,350 first-admission patients were discharged with a diagnosis of major affective disorder. For women with unipolar disorder and for all...... kinds of patients with bipolar disorder, the rate of recurrence was affected by the number of prior episodes even when the effect was adjusted for individual frailty toward recurrence. No effect of episodes but a large effect of the frailty parameter was found for unipolar men. The authors concluded...

  7. Recurrent hamburger thyrotoxicosis

    Science.gov (United States)

    Parmar, Malvinder S.; Sturge, Cecil

    2003-01-01

    RECURRENT EPISODES OF SPONTANEOUSLY RESOLVING HYPERTHYROIDISM may be caused by release of preformed hormone from the thyroid gland after it has been damaged by inflammation (recurrent silent thyroiditis) or by exogenous administration of thyroid hormone, which might be intentional or surreptitious (thyrotoxicosis factitia). Community-wide outbreaks of “hamburger thyrotoxicosis” resulting from inadvertent consumption of beef contaminated with bovine thyroid gland have been previously reported. Here we describe a single patient who experienced recurrent episodes of this phenomenon over an 11-year period and present an approach to systematically evaluating patients with recurrent hyperthyroidism. PMID:12952802

  8. Radon Progeny In Underground Phosphate Mines and Their Activity Distributions In Human Lung

    International Nuclear Information System (INIS)

    Abd El-Hady, M.; Mohammed, A.; El-Hussein, A.; Ali, A.E.; Ahmed, A.A.

    2001-01-01

    In addition to workers in uranium mines, the staff of other underground mines, such as worker in underground phosphate mines, Can be exposed to 222 Rn and its progeny. In this study the individual radon progeny concentrations were measured in three Egyptian underground phosphate mines to estimate the occupational exposure to the workers in those sites. Active techniques are employed to fulfill the objective of measuring individual radon progeny concentrations (C RaA , C RaB and C RaC ). The mean reported values of radon progeny concentrations exceed the action levels recommended by ICRP 65 (1993). Based on the physical properties of attached radon progeny aerosol and physiological parameters for heavy work activity which recommended by ICRP 66 (1994). the deposition fraction for each airway generation was calculated. From the measured individual radon progeny concentrations in these mines and the calculated values of deposition fractions, the surface activity distribution per generation were calculated in human respiratory system (BB and regions). The maximum values of these activities were found in the upper bronchial airway generations. According to the obtained results, some of the corrective actions were recommended in this study

  9. Effect of pollination mode on progeny of Panicum coloratum var. makarikariense: Implications for conservation and breeding

    Directory of Open Access Journals (Sweden)

    Lorena V. Armando

    2017-09-01

    Full Text Available Panicum coloratum var. makarikariense, a perennial grass native to Africa, is adapted to a wide range of soil and climatic conditions with potential to be used as forage in tropical and semi-arid regions around the world. Our objective was to understand how the pollination mode affects viable seed production and further survival of the progeny. We evaluated self- and open-pollinated progenies from different accessions by measuring the seed production of the parents and their germination performance, germination rate and seedling survival. Parents and progeny were also fingerprinted with Simple Sequence Repeats (SSR. Progeny produced through open-pollination resulted in significantly more filled seeds and superior seedling survival than self-pollination. These results indicate that accessions studied here rely heavily on cross-pollination, whereas the contribution of self-pollinated offspring to the population is likely to be low. SSR profiles showed that, on average, 85% of the progeny (arising from cross-pollination possessed paternal specific markers and 100% of them were genetically different from the maternal genotype. All plants examined had 4x = 36 chromosomes. Overall, our findings indicate that var. makarikariense is able to generate highly polymorphic progeny through segregation and recombination. This study provides reference information for the formulation of appropriate strategies for pasture germplasm management, conservation and development of breeding programs. 

  10. Nickel sulfate induces numerous defects in Caenorhabditis elegans that can also be transferred to progeny

    International Nuclear Information System (INIS)

    Wang Dayong; Wang Yang

    2008-01-01

    Whether the multiple biological toxicities from nickel exposure could be transferred to progeny has not been clarified. In this report, we explored the Caenorhabditis elegans to analyze the multiple toxicities of nickel and their possibly transferable properties. The nickel toxicity caused multiple biological defects in a concentration-dependent manner. Moreover, most of these toxicities could be transferred and could be only partially rescued in progeny. Some specific phenotypes in progeny were also found to exhibit no obvious rescue phenotypes or to show even more severe defects than their parents. The defects caused by nickel exposure could be classified into four groups according to their transferring properties. That is, the defects caused by nickel exposure could be largely, or partially, or unable to be rescued, or became even more severe in progeny animals. Therefore, most of the nickel exposure-caused defects can be transferred from parents to their progeny to different degrees in C. elegans. - Nickel exposure can cause multi-biological toxicities and these defects can be transferred from parents to their progeny in C. elegans

  11. Cytogenetic changes in the liver of progeny of irradiated male rats

    Energy Technology Data Exchange (ETDEWEB)

    Kropacova, K.; Slovinska, L.; Misurova, E. [P.J. Safarik Univ., Kosice (Slovakia)

    2002-06-01

    The transgenerational transmission of radiation damage of rat genom was studied on the basis of cytogenetic changes in somatic cells (hepatocytes). It was found, that the irradiation of rat males with dose of 3 Gy of gamma radiation caused latent cytogenetic damage to the liver, which was expressed during the course of an induced proliferation of hepatocytes (by partial hepatectomy) by lower proliferative activity and a high frequency of chromosomal aberrations. In the progeny of irradiated males (in the F{sub 1} generation), the radiation damage to DNA was manifested by similar changes, i.e. by lower proliferation activity and increase in ''spontaneous'' chromosomal aberration occurrence in liver regeneration after partial hepatectomy. Irradiating the progeny of irradiated males (the total radiation load of the progeny being 3 Gy+3 Gy) caused slighter changes in compared with irradiating the progeny of non-irradiated control males (the total radiation load of the progeny being 0 Gy+3 Gy), which suggests some kind of adaptive response, which was also found in other experimental systems and parameters. An analogous course of RNA and DNA quantitative changes in the liver of the F{sub 0} and F{sub 1} generations of rats confirms the partial transmission of radiation damage of genom to the progeny. (author)

  12. Nickel sulfate induces numerous defects in Caenorhabditis elegans that can also be transferred to progeny

    Energy Technology Data Exchange (ETDEWEB)

    Wang Dayong [Department of Genetics and Developmental Biology, Southeast University, Nanjing 210009 (China); Key Laboratory of Developmental Genes and Human Disease, Ministry of Education (China)], E-mail: dayongw@seu.edu.cn; Wang Yang [Department of Genetics and Developmental Biology, Southeast University, Nanjing 210009 (China); Key Laboratory of Developmental Genes and Human Disease, Ministry of Education (China)

    2008-02-15

    Whether the multiple biological toxicities from nickel exposure could be transferred to progeny has not been clarified. In this report, we explored the Caenorhabditis elegans to analyze the multiple toxicities of nickel and their possibly transferable properties. The nickel toxicity caused multiple biological defects in a concentration-dependent manner. Moreover, most of these toxicities could be transferred and could be only partially rescued in progeny. Some specific phenotypes in progeny were also found to exhibit no obvious rescue phenotypes or to show even more severe defects than their parents. The defects caused by nickel exposure could be classified into four groups according to their transferring properties. That is, the defects caused by nickel exposure could be largely, or partially, or unable to be rescued, or became even more severe in progeny animals. Therefore, most of the nickel exposure-caused defects can be transferred from parents to their progeny to different degrees in C. elegans. - Nickel exposure can cause multi-biological toxicities and these defects can be transferred from parents to their progeny in C. elegans.

  13. Plate-out rates of radon progeny and particles in a spherical chamber

    International Nuclear Information System (INIS)

    Cheng, Y.S.; Chen, B.T.

    1990-01-01

    In indoor and mining environments, deposition or ''plate-out'' of radon progeny onto walls occurs simultaneously with attachment of the radon progeny to airborne particles. Attachment and plate-out processes affect the atmosphere in which radon exposures takes place by reducing concentrations and shifting activity size distributions. Both processes have important consequences in determining the deposition pattern and initial dose of inhaled radon progeny. Theoretical deposition models show that turbulence and natural convection in a room are the major factors that influence plate-out rates. Here we describe plate-out measurements for radon progeny and aerosol particles in a spherical chamber under controlled laboratory conditions. The temperature and velocity profiles in still and turbulent air were monitored. A 161-liter spherical aluminum chamber was used to study the mixing. During mixing, air velocity was detected when rotational speeds were higher than 500 rpm. Monodisperse silver aerosols and polystyrene latex particles in the size range of 5 nm to 2 μm were used in the deposition study. Radon-220 progeny were generated by passing Rn-220 gas into the chamber and letting the gas decay into 212 Pb. The deposition rates of the particles and radon progeny ( 212 Pb) in the chamber were determined by monitoring the concentration decay of the aerosol as a function of time

  14. Observation of patients with vesicoureteral reflux off antibiotic prophylaxis: physician bias on patient selection and risk factors for recurrent febrile urinary tract infection.

    Science.gov (United States)

    Drzewiecki, Beth A; Thomas, John C; Pope, John C; Adams, Mark C; Brock, John W; Tanaka, Stacy T

    2012-10-01

    Observation off continuous antibiotic prophylaxis is an option for vesicoureteral reflux. We evaluated the characteristics of patients observed off continuous antibiotic prophylaxis and risk factors for febrile urinary tract infection. We identified children 1 to 18 years old with primary vesicoureteral reflux between January 1, 2010 and December 31, 2010. We excluded patients with prior surgical correction from analysis. We recorded age, gender, race/ethnicity, primary language, insurance carrier, age at vesicoureteral reflux diagnosis, initial presentation and vesicoureteral reflux severity. We quantified bladder and bowel dysfunction with a validated questionnaire if toilet trained. We compared patients off vs on continuous antibiotic prophylaxis with the chi-square test for categorical variables and the Mann-Whitney U test for continuous variables. We used a univariate Cox proportional hazards model to assess predictors of febrile urinary tract infection during observation off continuous antibiotic prophylaxis. Of 529 eligible patients 224 were observed off continuous antibiotic prophylaxis. Patients off continuous antibiotic prophylaxis tended to be older (p urinary tract infection (p = 0.05), to have nondilating vesicoureteral reflux on most recent cystogram (p urinary tract infection developed in 19 (8.5%). Risk factors associated with febrile urinary tract infection included initial presentation of multiple febrile urinary tract infections (p = 0.03), older age at diagnosis (p = 0.03) and older age starting observation off continuous antibiotic prophylaxis (p = 0.0003). Criteria to select patients with vesicoureteral reflux for observation off continuous antibiotic prophylaxis remain poorly defined in the literature. Observation will fail in a subset of patients with vesicoureteral reflux. Physician biases regarding patient selection for observation off continuous antibiotic prophylaxis should be considered when interpreting studies that evaluate treatment

  15. Recurrent Takotsubo Cardiomyopathy Related to Recurrent Thyrotoxicosis.

    Science.gov (United States)

    Patel, Keval; Griffing, George T; Hauptman, Paul J; Stolker, Joshua M

    2016-04-01

    Takotsubo cardiomyopathy, or transient left ventricular apical ballooning syndrome, is characterized by acute left ventricular dysfunction caused by transient wall-motion abnormalities of the left ventricular apex and mid ventricle in the absence of obstructive coronary artery disease. Recurrent episodes are rare but have been reported, and several cases of takotsubo cardiomyopathy have been described in the presence of hyperthyroidism. We report the case of a 55-year-old woman who had recurrent takotsubo cardiomyopathy, documented by repeat coronary angiography and evaluations of left ventricular function, in the presence of recurrent hyperthyroidism related to Graves disease. After both episodes, the patient's left ventricular function returned to normal when her thyroid function normalized. These findings suggest a possible role of thyroid-hormone excess in the pathophysiology of some patients who have takotsubo cardiomyopathy.

  16. Aggregate formation and suspension culture of human pluripotent stem cells and differentiated progeny.

    Science.gov (United States)

    Hookway, Tracy A; Butts, Jessica C; Lee, Emily; Tang, Hengli; McDevitt, Todd C

    2016-05-15

    Culture of human pluripotent stem cells (hPSC) as in vitro multicellular aggregates has been increasingly used as a method to model early embryonic development. Three-dimensional assemblies of hPSCs facilitate interactions between cells and their microenvironment to promote morphogenesis, analogous to the multicellular organization that accompanies embryogenesis. In this paper, we describe a method for reproducibly generating and maintaining populations of homogeneous three-dimensional hPSC aggregates using forced aggregation and rotary orbital suspension culture. We propose solutions to several challenges associated with the consistent formation and extended culture of cell spheroids generated from hPSCs and their differentiated progeny. Further, we provide examples to demonstrate how aggregation can be used as a tool to select specific subpopulations of cells to create homotypic spheroids, or as a means to introduce multiple cell types to create heterotypic tissue constructs. Finally, we demonstrate that the aggregation and rotary suspension method can be used to support culture and maintenance of hPSC-derived cell populations representing each of the three germ layers, underscoring the utility of this platform for culturing many different cell types. Copyright © 2015 Elsevier Inc. All rights reserved.

  17. The selective treatment of clinical mastitis based on on-farm culture results: II. Effects on lactation performance, including clinical mastitis recurrence, somatic cell count, milk production, and cow survival.

    Science.gov (United States)

    Lago, A; Godden, S M; Bey, R; Ruegg, P L; Leslie, K

    2011-09-01

    The objective of this multi-state, multi-herd clinical trial was to report on the efficacy of using an on-farm culture system to guide strategic treatment decisions in cows with clinical mastitis. The study was conducted in 8 commercial dairy farms ranging in size from 144 to 1,795 cows from Minnesota, Wisconsin, and Ontario, Canada. A total of 422 cows affected with mild or moderate clinical mastitis in 449 quarters were randomly assigned to either (1) a positive-control treatment program or (2) an on-farm culture-based treatment program. Quarter cases assigned to the positive-control group received immediate on-label intramammary treatment with cephapirin sodium. Quarters assigned to the culture-based treatment program were not treated until the results of on-farm culture were determined after 18 to 24h of incubation. Quarters in the culture-based treatment program that had gram-positive growth or a mixed infection were treated according to label instruction using intramammary cephapirin sodium. Quarters assigned to the culture-based treatment program that had gram-negative or no-growth did not receive intramammary therapy. It was already reported in a companion paper that the selective treatment of clinical mastitis based on on-farm culture results decreases antibiotic use by half and tends to decrease milk withholding time without affecting short-term clinical and bacteriological outcomes. The present article reports on long-term outcomes of the aforementioned study. No statistically significant differences existed between cases assigned to the positive-control program and cases assigned to the culture-based treatment program in risk and days for recurrence of clinical mastitis in the same quarter (35% and 78 d vs. 43% and 82 d), linear somatic cell count (4.2 vs. 4.4), daily milk production (30.0 vs. 30.7 kg), and risk and days for culling or death events (28% and 160 d vs. 32% and 137 d) for the rest of the lactation after enrollment of the clinical mastitis

  18. Immunological status of the progeny of breeder hens kept on ochratoxin A (OTA)-contaminated feed.

    Science.gov (United States)

    Zahoor-Ul-Hassan; Khan, Muhammad Zargham; Khan, Ahrar; Javed, Ijaz; Saleemi, Muhammad Kashif

    2011-06-01

    This study aimed to evaluate the immunological status of the progeny of breeder hens kept on ochratoxin A (OTA)-contaminated feed. For this purpose, 84 White Leghorn (WL) layer breeder hens (40-weeks-of-age) were divided into seven groups (A-G). Hens in the Group A were fed a commercial layer ration while those in Groups B-G were kept on a diet amended with 0.1, 0.5, 1.0, 3.0, 5.0, or 10.0 mg OTA/kg, respectively, for 3 weeks. Fertile eggs were set for hatching on the weekly basis to get the progeny of each week separately. Hatched chicks (n = 10 from each group) were euthanized at Day 14 of age, and their immunological organs weighed and fixed in neutral buffered formalin. An indirect immunoperoxidase method was applied to study the frequency of immunoglobulin(s)-bearing cells in the spleen and bursa of Fabricius from these progeny. From other chicks within each set, at Day 16 of age, lymphoblastogenic responses against an intradermal administration of phytohemagglutinin (PHA-P) were determined. Relative weights of the bursa of Fabricius and of the thymus were significantly lower in the progeny of hens fed OTA-contaminated diet for 14 and 21 days. The frequencies of IgA-, IgG-, and IgM-bearing cells were also significantly (P ≤ 0.05) lower in the bursa of Fabricius and spleen of the progeny chicks obtained from dams fed the OTA-mixed diet. Progeny chicks obtained from the breeder hens fed higher doses of OTA showed significantly lower responses to PHA-P than did counterpart chicks from control hens. The findings of this study suggested that there were immunosuppressive effects from OTA in the progeny obtained from breeder hens kept on OTA-contaminated diets.

  19. Chromosomal Behavior during Meiosis in the Progeny of Triticum timopheevii × Hexaploid Wild Oat.

    Directory of Open Access Journals (Sweden)

    Hongzhou An

    Full Text Available The meiotic behavior of pollen mother cells (PMCs of the F2 and F3 progeny from Triticum timopheevii × hexaploid wild oat was investigated by cytological analysis and sequential C-banding-genomic in situ hybridization (GISH in the present study. A cytological analysis showed that the chromosome numbers of the F2 and F3 progeny ranged from 28 to 41. A large number of univalents, lagging chromosomes, chromosome bridges and micronuclei were found at the metaphase I, anaphase I, anaphase II and tetrad stages in the F2 and F3 progeny. The averages of univalents were 3.50 and 2.73 per cell, and those of lagging chromosomes were 3.37 and 1.87 in the F2 and F3 progeny, respectively. The PMC meiotic indices of the F2 and F3 progeny were 12.22 and 20.34, respectively, indicating considerable genetic instability. A sequential C-banding-GISH analysis revealed that some chromosomes and fragments from the hexaploid wild oat were detected at metaphase I and anaphase I in the progeny, showing that the progeny were of true intergeneric hybrid origin. The alien chromosomes 6A, 7A, 3C and 2D were lost during transmission from F2 to F3. In addition, partial T. timopheevii chromosomes appeared in the form of univalents or lagging chromosomes, which might result from large genome differences between the parents, and the wild oat chromosome introgression interfered with the wheat homologues' normally pairing.

  20. Milk production and composition, and progeny performance in young ewes with high merit for rapid growth and muscle and fat accumulation.

    Science.gov (United States)

    Rosales Nieto, C A; Ferguson, M B; Macleay, C A; Briegel, J R; Wood, D A; Martin, G B; Bencini, R; Thompson, A N

    2018-02-26

    In ewe lambs, acceleration of growth and accumulation of both muscle and fat leads to earlier sexual maturity and better reproductive performance. The next stage in the development of this theme is to test whether these aspects of growth in young ewes affect milk production in their first lactation and the growth of their first progeny. We studied 75 young Merino ewes that had known phenotypic values for depth of eye muscle (EMD) and fat (FAT), and known Australian Sheep Breeding Values for post-weaning weight (PWT) and depths of eye muscle (PEMD) and fat (PFAT). They lambed for the first time at 1 year of age. Their lambs were weighed weekly from birth to weaning at 10 weeks to determine live weight gain and weaning weight. Progeny birth weight was positively associated with live weight gain and weaning weight (P0.05). The PWT of the sire was positively associated with live weight gain (P0.05). The concentrations of fat, protein, lactose and total solids in the milk were not affected by the phenotype or genotype of the mothers or of the sires of the mothers, or by the sex of the progeny (P>0.05). We conclude that selection of young Merino ewes for better growth, and more rapid accumulation of muscle and fat, will lead to progeny that are heavier at birth, grow faster and are heavier at weaning. Moreover, milk production and composition do not seem to be affected by the genetic merit of the mother for post-weaning live weight or PEMD or PFAT. Therefore, Merino ewes can lamb at 1 year of age without affecting the production objectives of the Merino sheep industry.

  1. Measurement of the deposited activity of the short-lived radon progeny in the human respiratory tract

    International Nuclear Information System (INIS)

    Vezzu, G.; Butterweck-Dempewolf, G.; Schuler, C.

    1998-01-01

    Volunteers were exposed in the radon chamber at Paul Scherrer Institut to an atmosphere enriched with highly unattached radon progeny. The deposited radon progeny activity in the respiratory tract of the volunteers was determined using a low level in-vivo counter. The detector arrangement and its calibration for the measurement of deposited radon progeny activity is described and the results for a mouth and a nose breathing volunteer are presented. For the nose breathing volunteer 55% of the deposited radon progeny activity was located in the head and the remaining 45% in the chest whereas for the mouth breathing volunteer 25% was located in the head and the remaining 75% in the chest. A mean clearance half-life for the deposited radon progeny from the respiratory tract of (2±1) h was obtained from the analyses of the temporal behaviour of the deposited radon progeny activity in the head. (orig.)

  2. Influence of 2-(18F) fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography on recurrent ovarian cancer diagnosis and on selection of patients for secondary cytoreductive surgery

    DEFF Research Database (Denmark)

    Risum, Signe; Høgdall, Claus; Markova, Elena

    2009-01-01

    physical examination, US, or increasing cancer antigen 125 (CA125) level (>50 U/mL or >15% above baseline level). Recurrent OC was diagnosed 58 times in 52 patients. The sensitivities of US, CT, and PET/CT for diagnosing recurrence were 66% (P = 0.003), 81% (P = 0.0001), and 97% (P ...The objective of this prospective study was to compare the sensitivities and the specificities of combined 2-(F) fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography (PET/CT), abdominal/transvaginal ultrasound (US), and CT for diagnosing recurrent ovarian cancer (OC......) and to evaluate the influence of PET/CT on referral of patients with solitary recurrence to secondary cytoreductive surgery. From April 2005 to November 2007, 60 patients were consecutively included to PET/CT 68 times. The inclusion criteria were remission of 3 months or longer and recurrent OC suspected from...

  3. Salvage photodynamic therapy for recurrent nasopharyngeal carcinoma.

    Science.gov (United States)

    Succo, Giovanni; Rosso, S; Fadda, G L; Fantini, M; Crosetti, Erika

    2014-06-01

    To evaluate the feasibility of photodynamic therapy (NP-PDT) in the palliative management of recurrent/persistent nasopharyngeal cancer (NFC). Six patients with persistent/recurrent NPC underwent PDT with palliative intent. NP-PDT was delivered by three different methods depending on the localization, size and depth of the lesion: type I NP-PDT: transnasal direct illumination of postero-superior recurrence; type II NP-PDT: transnasal direct illumination of the whole nasopharynx; type III NP-PDT: transoral direct or interstitial illumination of lateral recurrence. In this case, the ENT-magnetic navigation system (MNS) was extremely useful in identifying the tumor and its distance from the ICA. Both patients treated with NP-PDT type I are free from disease at 38 and 71 months after treatment; both patients treated with NP-PDT type II experienced further local and loco-regional recurrence of disease within 16 months; one died of the disease while the second underwent a second palliative treatment, NP-PDT type I, and is currently living with the disease; of the two patients who underwent NP-PDT type III, one died as a result of regional and systemic recurrence without local recurrence while the second experienced a superficial recurrence. He underwent a second NP-PDT type III treatment and is currently free from disease at 21 months. NP-PDT is a non-invasive and simple treatment modality that may have an important role in the treatment of selected cases of persistent/recurrent NPC in its early stage, not suitable for a conventional therapeutic protocol. Coupling NP-PDT with the ENT-MNS can be an effective strategy to obtain more precise light delivery within the tumor, particularly in lateral and parapharyngeal localization. Copyright © 2014 The Authors. Published by Elsevier B.V. All rights reserved.

  4. RECURRENT CROUP IN CHILDREN

    Directory of Open Access Journals (Sweden)

    S. L. Piskunova

    2014-01-01

    Full Text Available The article presents the results of examination of 1849 children, entering children's infectioushospitalofVladivostokwith the clinical picture of croup of viral etiology. The clinical features of primary and recurrent croup are described. Frequency of recurrent croup inVladivostokis 8%. Children with a recurrent croup had the burdened premorbid background, and also persistent herpetic infections (cytomegalic infection in 42,9% cases, cytomegalic infection in combination with the herpes simplex virus -1. Frequency of croups substantially rose in the period of epidemic of influenza.

  5. An intercomparison between gross α counting and gross β counting for grab-sampling determination of airborne radon progeny and thoron progeny

    International Nuclear Information System (INIS)

    Papp, Z.

    2006-01-01

    The instantaneous values of the airborne activity concentrations of radon progeny and thoron progeny have been determined 34 times in a closed and windowless room in a cellar using two independent grab-sampling methods in order to compare the performance of the methods. The activity concentration of radon ( 222 Rn) was also measured and it varied between 200 and 650 Bq m -3 . Two samples of radon and thoron progeny were collected simultaneously from roughly the same air volume by filtering. For the first method, the isotopes were collected on membrane filter and gross α counting was applied over several successive time intervals. This method was a slightly improved version of the methods that are applied generally for this reason for decades. For the second method, the isotopes were collected on glass-fibre filter and gross β counts were registered over several time intervals. This other method was developed a few years ago and the above series of measurements was the first opportunity to make an intercomparison between it and another similar method based on α counting. Individual radon progeny and thoron progeny activity concentrations (for the isotopes 218 Po, 214 Pb, 214 Bi and 212 Pb) were evaluated by both methods. The detailed investigation of the results showed that the systematic deviation of the methods is small but significant and isotope-dependent. The weighted averages of the β/α activity concentration ratios for 218 Po, 214 Pb, 214 Bi, EEDC 222 (Equilibrium-Equivalent Decay-product Concentration of radon progeny) and 212 Pb were 0.99±0.03, 0.90±0.02, 1.03±0.02, 0.96±0.02 and 0.80±0.03, respectively. The source of the systematic deviation is probably the inaccurate knowledge of the counting efficiencies mainly in the case of the α-counting method. A significant random-type difference between the results obtained with the two methods has also been revealed. For example, the β/α ratio for EEDC 222 varied between 0.81±0.01 and 1.22±0

  6. Selection arena in Aspergillus nidulans

    NARCIS (Netherlands)

    Bruggeman, J.; Debets, A.J.M.; Hoekstra, R.F.

    2004-01-01

    The selection arena hypothesis states that overproduction of zygotes-a widespread phenomenon in animals and plants-can be explained as a mechanism of progeny choice. As a similar mechanism, the ascomycetous fungus Aspergillus nidulans may overproduce dikaryotic fruit initials, hereafter called

  7. Radioactivity on the surfaces of computer monitors and television screens due to progeny palatal

    International Nuclear Information System (INIS)

    Abdel-Nady, A.; Morsy, A.A.

    2002-01-01

    Computer monitors and television screens can collect radon progeny. Radon decay forming meta-stable progeny, namely, Po-218, Po-214, and Po-210, which are found mostly in positively, charged aerosol particles. These particles are attract by the large negative field of a video display terminals (VDT) leading to buildup of radioactivity on the VDT screen. The charged aerosol particles might drift in the electric field between the VDT and the operator and be accelerated into the operator's face. The aim of this work is to measure these phenomena set of ultra-sensitive TASTRAK detectors used to measure the plate out of positively charged radioactive radon progeny. The track detectors were fixed on the outer monitor screen. For an occupational computer worker spending 200 days per year for 6 hours a day. It was found that the mean dose equivalent was 1.77 mSv, 0.25 mSv/year for normal CRT and LCD monitors respectively

  8. Experimental determination of the absorption rate of unattached radon progeny from respiratory tract to blood

    International Nuclear Information System (INIS)

    Butterweck, G.; Schuler, Ch.; Vessl, G.; Mueller, R.; Marsh, J.W.; Thrift, S.; Birchall, A.

    2002-01-01

    An exposure methodology was developed for the determination of the absorption rate of unattached radon progeny deposited in the human respiratory tract to blood. Twenty-one volunteers were exposed in a radon chamber during well-controlled aerosol and radon progeny conditions, with predominantly unattached radon daughters. Special efforts were made to restrict the dose to the volunteers to an absolute maximum of 0.08 mSv. Measurements of radon gas and radon progeny in blood samples of these volunteers indicated absorption half times of 20 min to 60 min. Former determinations, mainly performed with much larger aerosol particles of diameters between 100 nm and 1000 nm, implied absorption half times around 10 h. This indicates that the absorption of radon decay products from ciliated airways into blood is dependent upon particle size and particle composition. (author)

  9. Relationship of 220Rn and 222Rn progeny levels in Canadian underground U mines

    International Nuclear Information System (INIS)

    Bigu, J.

    1988-01-01

    Radon-222 and 220 Rn progeny are found in some Canadian underground U mines. Because both can contribute to lung dose, their experimental determinations are important. The relationship between 222 Rn progeny Working Level [WL(Rn)] and 220 Rn progeny Working Level [WL(Tn)] has been investigated in U mines. Experimental measurements extended from 1981 to 1986 and consisted of about 700 measurements of each WL(Rn) and WL(Tn). The data were analyzed by standard linear and power-function regression analysis. A power-function relationship between WL(Rn) and WL(Tn) seemed to fit the experimental data best. The relationship obtained permits the calculation of WL(Tn) from experimental values of WL(Rn). The relationship is useful for lung-dose-calculation purposes and in mine-ventilation-engineering calculations

  10. Lipid peroxidation and seed emergency in progenies of the yellow passion fruit plant

    Directory of Open Access Journals (Sweden)

    João Paulo Bestete de Oliveira

    2012-09-01

    Full Text Available The objective was to evaluate the percentage of emergency plantlets and lipid peroxidation in seeds of 29 half-sib progenies of yellow passion fruit (Passiflora edulis Sims. after 24 months under storage. The experimental design was completely randomized, with four replications of 50 seeds each, from which the treatments were the progenies (1-29. The evaluation of the percent plantlet emergency was accomplished at 14 and 28 days after sowing. The lipid peroxidation of the seeds was expressed as malondialdehyde (MDA content that was determined by the TBARS method. Approximately 21% of those half-sib progenies maintained the viability of their seeds for twenty-four months under storage. The results point out a remarkable genetic variability for vigor and emergency of the yellow passion fruit plantlets, with occurrence of individuals with high and other ones with low capacity to maintaining the physiologic quality of their seeds after storage.

  11. Occurrence of 222Rn and progeny in natural gas processing plants in western Canada

    International Nuclear Information System (INIS)

    Drummond, I.; Boucher, P.; Bradford, B.; Evans, H.; McLean, J.; Reczek, E.; Thunem, H.

    1990-01-01

    In Western Canada, there are many plants that process natural gas to remove impurities (CO 2 , H 2 S, H 2 O) and recover natural gas liquids (propane, butane, etc.). Trace quantities of 222 Rn present in the inlet stream are concentrated in streams rich with propane. Potential hazards to plant operators include direct inhalation of 222 Rn and progeny; exposure to gamma radiation from short-lived progeny deposited inside equipment; or inhalation of 210 Pb when contaminated equipment is opened for repair. Twenty-four plants operated by seven companies cooperated to assess these potential hazards. The findings indicate a substantial flux of 222 Rn and progeny passing through the plants, but little accumulation of radionuclides. In no case was there evidence of significant exposure of plant operators or maintenance personnel to ionizing radiation. Further investigation of pipeline operations, and chemical operations using natural gas liquids as feed stock, is recommended

  12. Study of the atmospheric chemistry of radon progeny in laboratory and real indoor atmospheres

    Energy Technology Data Exchange (ETDEWEB)

    Hopke, P.K.

    1992-07-01

    This report covers the second year of the 28 month grant current grant to Clarkson University to study the chemical and physical behavior of the polonium 218 atom immediately following its formation by the alpha decay of radon. Because small changes in size for activity result in large changes in the delivered dose per unit exposure, this behavior must be understood if the exposure to radon progeny and it dose to the cells in the respiratory tract are to be fully assessed. Two areas of radon progeny behavior are being pursued; laboratory studies under controlled conditions to better understand the fundamental physical and chemical process that affect the progeny's atmospheric behavior and studies in actual indoor environments to develop a better assessment of the exposure of the occupants of that space to the size and concentration of the indoor radioactive aerosol. This report describes the progress toward achieving these objectives.

  13. Intercomparison of active and passive instruments for radon and radon progeny in North America

    International Nuclear Information System (INIS)

    George, A.C.; Tu, Keng-Wu; Knutson, E.O.

    1995-02-01

    An intercomparison exercise for radon and radon progeny instruments and methods was held at the Environmental Measurements Laboratory (EML) from April 22--May 2, 1994. The exercise was conducted in the new EML radon test and calibration facility in which conditions of exposure are very well controlled. The detection systems of the intercompared instruments consisted of. (1) pulse ionization chambers, (2) electret ionization chambers, (3) scintillation detectors, (4) alpha particle spectrometers with silicon diodes, surface barrier or diffused junction detectors, (5) registration of nuclear tracks in solid-state materials, and (6) activated carbon collectors counted by gamma-ray spectrometry or by alpha- and beta-liquid scintillation counting. 23 private firms, government laboratories and universities participated with a 165 passive integrating devices consisting of: Activated carbon collectors, nuclear alpha track detectors and electret ionization chambers, and 11 active and passive continuous radon monitors. Five portable integrating and continuous instruments were intercompared for radon progeny. Forty grab samples for radon progeny were taken by five groups that participated in person to test and evaluate their primary instruments and methods that measure individual radon progeny and the potential alpha energy concentration (PAEC) in indoor air. Results indicate that more than 80% of the measurements for radon performed with a variety of instruments, are within ±10% of actual value. The majority of the instruments that measure individual radon progeny and the PAEC gave results that are in good agreement with the EML reference value. Radon progeny measurements made with continuous and integrating instruments are satisfactory with room for improvement

  14. Wire screens as a tool for survey measurements of the unattached radon progeny in mines

    International Nuclear Information System (INIS)

    Janica, R.

    1996-07-01

    The radon hazard in mines is assessed by measuring the radioactivity accumulated on filters through which air is forced to flow. The filter collects both forms of the short-lived radon progeny, attached and unattached, and, therefore, the assessment is based on the measurement of the total radon progeny. Because of the special radiological significance of the unattached fraction of the short-lived radon progeny, the estimation of the radiation hazard to miners would be improved if the unattached fraction could be measured. This report describes two methods of measurement for the simultaneous determination of the unattached and the total radon progeny. The proposed methods comply with the criterion of practicality (imposed by the working conditions in the mine environment), that is, they are implemented using standard survey equipment and simple procedures. Both methods use wire screens to collect, preferentially, the unattached fraction. According to the first method, air is sampled through a wire screen and a backup filter, and the radioactivity accumulated on both the filter and the wire screen are measured separately using standard counting protocols (e.g. the Kusnetz protocol). The wire screen's efficiency for collecting the unattached radon progeny is determined, in advance, under laboratory conditions. The method assumes the validity of the collection efficiencies when the screens are used under field conditions. To avoid the uncertainty of the lab-determined collection efficiency, a new measuring method was proposed based on the sampling of air through two screens in series and a backup filter. The measurement of the ratio of the activities deposited on both screens allows an estimation of the screen collection efficiency under field conditions. Once this is done, the 'unattached fraction' and total radon progeny are determined by counting only one of the screens and the backup filter as described in the previous method. (author). 73 refs., 8 tabs., 21 figs

  15. Differentiation of hematopoietic stem cells in irradiated mouse thymic lobes. Kinetics and phenotype of progeny

    International Nuclear Information System (INIS)

    Spangrude, G.J.; Scollay, R.

    1990-01-01

    To define cell populations which participate in the very early stages of T cell development in the mouse thymus, we enriched hematopoietic stem cells from mouse bone marrow and injected them into thymic lobes of irradiated Ly-5 congenic recipients. The progeny of the stem cells were identified and their phenotypes were determined by two-color flow cytometry for the expression of various cell surface differentiation Ag during the course of their subsequent intrathymic development. The majority of the differentiation which occurred in the first 10 days after intrathymic cell transfer was myeloid in nature; hence, this study demonstrates that the irradiated thymus is not strictly selective for T cell development. Further, the maximum rate of T cell development was observed after intrathymic injection of 200 stem cells. Donor-derived cells which did not express Ag characteristic of the myeloid lineage could be detected and their phenotypes could be determined by flow cytometry as early as 7 days after intrathymic injection. At this time, the cells were still very similar phenotypically to the bone marrow hematopoietic stem cells. Exceptions to this were the expression of stem cell Ag 2 and a decrease in the level of MHC class I Ag expression. After 9 days, the donor-derived cells expressed high levels of the Thy-1 Ag and proceeded to change in cell surface phenotype as differentiation continued. These cell phenotypes are described for the time frame ending 18 days after injection, when most donor-derived cells were phenotypically small CD4+ CD8+ (double-positive) thymocytes

  16. Post-weaning feed efficiency decreased in progeny of higher milk yielding beef cows.

    Science.gov (United States)

    Mulliniks, J T; Edwards, S R; Hobbs, J D; McFarlane, Z D; Cope, E R

    2018-02-01

    Current trends in the beef industry focus on selecting production traits with the purpose of maximizing calf weaning weight; however, such traits may ultimately decrease overall post-weaning productivity. Therefore, the objective of this study was to evaluate the effects of actual milk yield in mature beef cows on their offspring's dry matter intake (DMI), BW, average daily gain, feed conversion ratio (FCR) and residual feed intake (RFI) during a ~75-day backgrounding feeding trial. A period of 24-h milk production was measured with a modified weigh-suckle-weigh technique using a milking machine. After milking, cows were retrospectively classified as one of three milk yield groups: Lower (6.57±1.21 kg), Moderate (9.02±0.60 kg) or Higher (11.97±1.46 kg). Calves from Moderate and Higher milk yielding dams had greater (Pfeeding phase; however, day 75 BW were not different (P=0.36) between Lower and Moderate calves. Body weight gain was greater (P=0.05) for Lower and Moderate calves from the day 0 BW to day 35 BW compared with Higher calves. Overall DMI was lower (P=0.03) in offspring from Lower and Moderate cows compared with their Higher milking counterparts. With the decreased DMI, FCR was lower (P=0.03) from day 0 to day 35 in calves from Lower and Moderate milk yielding dams. In addition, overall FCR was lower (P=0.02) in calves from Lower and Moderate milk yielding dams compared with calves from Higher milk yielding dams. However, calving of Lower milk yielding dams had an increased (P=0.04) efficiency from a negative RFI value compared with calves from Moderate and Higher milking dams. Results from this study suggest that increased milk production in beef cows decreases feed efficiency during a 75-day post-weaning, backgrounding period of progeny.

  17. Transcriptomic Analysis Using Olive Varieties and Breeding Progenies Identifies Candidate Genes Involved in Plant Architecture.

    Science.gov (United States)

    González-Plaza, Juan J; Ortiz-Martín, Inmaculada; Muñoz-Mérida, Antonio; García-López, Carmen; Sánchez-Sevilla, José F; Luque, Francisco; Trelles, Oswaldo; Bejarano, Eduardo R; De La Rosa, Raúl; Valpuesta, Victoriano; Beuzón, Carmen R

    2016-01-01

    Plant architecture is a critical trait in fruit crops that can significantly influence yield, pruning, planting density and harvesting. Little is known about how plant architecture is genetically determined in olive, were most of the existing varieties are traditional with an architecture poorly suited for modern growing and harvesting systems. In the present study, we have carried out microarray analysis of meristematic tissue to compare expression profiles of olive varieties displaying differences in architecture, as well as seedlings from their cross pooled on the basis of their sharing architecture-related phenotypes. The microarray used, previously developed by our group has already been applied to identify candidates genes involved in regulating juvenile to adult transition in the shoot apex of seedlings. Varieties with distinct architecture phenotypes and individuals from segregating progenies displaying opposite architecture features were used to link phenotype to expression. Here, we identify 2252 differentially expressed genes (DEGs) associated to differences in plant architecture. Microarray results were validated by quantitative RT-PCR carried out on genes with functional annotation likely related to plant architecture. Twelve of these genes were further analyzed in individual seedlings of the corresponding pool. We also examined Arabidopsis mutants in putative orthologs of these targeted candidate genes, finding altered architecture for most of them. This supports a functional conservation between species and potential biological relevance of the candidate genes identified. This study is the first to identify genes associated to plant architecture in olive, and the results obtained could be of great help in future programs aimed at selecting phenotypes adapted to modern cultivation practices in this species.

  18. Genetic evaluation of economic traits in progenies of Nigerian heavy ...

    African Journals Online (AJOL)

    toshiba

    2012-05-15

    May 15, 2012 ... attention of several investigators who found that there were wide ..... breeding and selective breeding of our local chicken could positively .... for egg number, egg weight and egg shell colour in three Catalan breed. Poult. Sci.

  19. Local deposition patterns of inhaled radon progeny in human bronchial airways

    International Nuclear Information System (INIS)

    Heistracher, T.; Hofmann, W.; Balashazy, I.

    1996-01-01

    The local distribution of radon decay products deposited within bronchial bifurcations, particularly the formation of hot spots, may be more relevant for the determination of cellular doses in bronchial tissue than the commonly computed deposition efficiency, which is conceptually equivalent to the assumption of a uniform nuclide distribution. It is well known that the initial states of lung cancer in humans preferably occur in upper airways close to the cardinal location. In this study we use a recently developed geometric approach of a physiologically realistic bifurcation to demonstrate the site sensitivity of radon progeny deposition for two particle sizes, which are representative of the unattached and attached fraction of radon progeny

  20. Dose-dependent in vivo cell-cycle changes following radon progeny exposure

    International Nuclear Information System (INIS)

    Johnson, N.F.; Carpenter, T.R.; Hickman, A.W.; Jaramillo, R.J.; Gurule, D.M.

    1994-01-01

    Exposures to low concentrations of alpha-emitting radon progeny are reported by the U.S. Environmental Protection Agency to be the second leading cause of lung cancer. Current risk estimates for lung cancer from the inhalation of radon progeny are based on data from underground uranium miners. To produce such risk estimates, calculations are based on several assumptions concerning exposure-response relationships rather than dose-response relationships. A better understanding of the mechanisms of interactions between alpha particles, the cells of the respiratory tract, and the progression toward cancer may validate the mathematical models used to derive risk estimates

  1. Effect of ventilation rate on concentrations of indoor radon and its progenies

    International Nuclear Information System (INIS)

    Wang Chunhong; Liu Yanyang; Liu Fudong; Liu Senlin; Chen Ling

    2012-01-01

    To study concentrations of indoor radon and its progenies, ventilation rates and their corresponding concentrations of indoor radon and its progenies were measured using tracer-gas dilution method. Results show that both ventilation rates and concentrations of indoor radon varied insignificantly and radon concentration were higher than the outdoor environment while doors and windows were all closed with air-conditioner on and off respectively; the concentrations declined and close to the outdoor level when doors and windows were all open with ventilators in operation. Accordingly, in modern life, especially in summer, people's preference for air-conditioners but natural ventilation would result in an increase of indoor radon concentration. (authors)

  2. Effect of strenuous maternal exercise before and during pregnancy on rat progeny renal function

    Directory of Open Access Journals (Sweden)

    Oliveira A.O.

    2004-01-01

    Full Text Available The effects of strenuous exercise before and during pregnancy on the renal function and morphological alterations of the progeny were determined in a study on female Wistar rats. This research was done based on a previous study carried out in our laboratory, which showed morphological alterations in rats submitted to this kind of exercise. As the form is related to the function, the physiological relevance of submitting a pregnant female to a high-intensity exercise training regimen could be explained by the fact that morphological alterations can influence kidney function. The animals were assigned to one of two groups: control animals that did not exercise during pregnancy and trained animals that swam for 120 min 5 days a week for 8 weeks before pregnancy and daily for 60 min over a period of 8 weeks starting on the second day of pregnancy. Seven rats of each group were analyzed for morphological alterations and for renal function. The progeny of the rats used for morphological evaluation were born by cesarean section and the progeny of the animals used to evaluate renal function were born normally. The progeny were two months old when renal function was evaluated. Fertility and morbidity were the same for both groups. Strenuous maternal exercise had no significant influence on glomerular filtration rate (GFR but renal plasma flow was lower in the progeny of the trained group (mean ± SD, 16.65 ± 3.77 ml min-1 kg-1 compared to the progeny of the control group (33.42 ± 2.56 ml min-1 kg-1. Antidiuretic and antinatriuretic effects on the progeny of the trained group were observed, since urine flow as percentage of GFR and the fraction of urinary sodium excretion were lower in this group (1.38 ± 0.10 and 0.60 ± 0.04%, respectively compared to the progeny of the control group (2.36 ± 0.11 and 1.55 ± 0.20%, respectively. Moreover, in this exercise program, fetuses from trained animals were small-sized (2.45 ± 0.19 vs 4.66 ± 2.45 g for

  3. A family business: stem cell progeny join the niche to regulate homeostasis.

    Science.gov (United States)

    Hsu, Ya-Chieh; Fuchs, Elaine

    2012-01-23

    Stem cell niches, the discrete microenvironments in which the stem cells reside, play a dominant part in regulating stem cell activity and behaviours. Recent studies suggest that committed stem cell progeny become indispensable components of the niche in a wide range of stem cell systems. These unexpected niche inhabitants provide versatile feedback signals to their stem cell parents. Together with other heterologous cell types that constitute the niche, they contribute to the dynamics of the microenvironment. As progeny are often located in close proximity to stem cell niches, similar feedback regulations may be the underlying principles shared by different stem cell systems.

  4. Selection of F4 coffee progenies, obtained from Icatu x Catimor cross

    OpenAIRE

    Botelho, César Elias; Mendes, Antônio Nazareno Guimarães; Carvalho, Gladyston Rodrigues; Bartholo, Gabriel Ferreira; Carvalho, Samuel Pereira

    2010-01-01

    Com o objetivo de selecionar progênies de cafeeiros produtivos e resistentes à ferrugem foi instalado e conduzido um experimento em Machado,MG. Foram avaliadas 29 progênies selecionadas pelo programa de melhoramento genético do cafeeiro, coordenado pela EPAMIG, obtidas a partir do cruzamento Icatu e Catimor. O cultivar Rubi MG 1192 foi utilizado como testemunha. O delineamento experimental adotado foi o de blocos casualizados, com três repetições. Foram analisados a produção de café beneficia...

  5. Hyperhomocysteinemia in Recurrent Miscarriage

    International Nuclear Information System (INIS)

    Gaber, Kh.R.; Farag, M.K.; Soliman, S.Et.; Abd Al-Kaderm, M.A.

    2008-01-01

    Objective: An elevated total plasma homocysteine level has been suggested as a possible risk factor in women suffering from recurrent pregnancy loss. The current study was undertaken to assess the association between homocysteine, folate, cobalamin (vitamin B12) and the risk of recurrent pregnancy loss. Design: Case . control study Materials and Methods: The study included 57 non-pregnant Egyptian women. They were classified according to their obstetric history into 2 groups: 32 cases with at least two consecutive miscarriages (Study group), and 25 cases with normal obstetric history (Control group). All cases were tested for plasma total homocysteine, serum folate and cobalamin (vitamin B12). Results: The fasting total homocysteine was significantly higher in the study group as compared to the control group. While the median concentrations for the vitamins studied were significantly lower in women of the study group as compared to the controls. Elevated homocysteine and reduced vitamin B12 can be considered risk factors for recurrent miscarriage with odds ratio (OR) and 95% confidence intervals (95% CI) of 1.839 (1.286, 2.63) and 1.993 (1.346, 2.951) respectively in the group of recurrent miscarriages. The OR (95% CI) in the study population for low serum folate concentrations was 1.23 (0.776, 2.256). Conclusion: Elevated homocysteine and reduced serum vitamin B12 are risk factors for recurrent miscarriage. Low serum folate did not seem a risk factor for recurrent miscarriage. Testing for homocysteine levels in women suffering from unexplained recurrent miscarriage and pre-conceptional supplementation with vitamin B12 might be beneficial to improve pregnancy outcome

  6. Hyperhomocysteinemia in Recurrent Miscarriage

    Energy Technology Data Exchange (ETDEWEB)

    Gaber, Kh R; Farag, M K [Prenatal Diagnosis and Fetal Medicine Department, National Research Centre, Dokki, Giza (Egypt); Soliman, S Et [Radioisotope Department, Nuclear Research Centre, Atomic Energy Authority, Cairo (Egypt); Abd Al-Kaderm, M A [Obstetrics and Gynecology Department, Faculty of Medicine, Cairo University, Cairo (Egypt)

    2008-07-01

    Objective: An elevated total plasma homocysteine level has been suggested as a possible risk factor in women suffering from recurrent pregnancy loss. The current study was undertaken to assess the association between homocysteine, folate, cobalamin (vitamin B12) and the risk of recurrent pregnancy loss. Design: Case . control study Materials and Methods: The study included 57 non-pregnant Egyptian women. They were classified according to their obstetric history into 2 groups: 32 cases with at least two consecutive miscarriages (Study group), and 25 cases with normal obstetric history (Control group). All cases were tested for plasma total homocysteine, serum folate and cobalamin (vitamin B12). Results: The fasting total homocysteine was significantly higher in the study group as compared to the control group. While the median concentrations for the vitamins studied were significantly lower in women of the study group as compared to the controls. Elevated homocysteine and reduced vitamin B12 can be considered risk factors for recurrent miscarriage with odds ratio (OR) and 95% confidence intervals (95% CI) of 1.839 (1.286, 2.63) and 1.993 (1.346, 2.951) respectively in the group of recurrent miscarriages. The OR (95% CI) in the study population for low serum folate concentrations was 1.23 (0.776, 2.256). Conclusion: Elevated homocysteine and reduced serum vitamin B12 are risk factors for recurrent miscarriage. Low serum folate did not seem a risk factor for recurrent miscarriage. Testing for homocysteine levels in women suffering from unexplained recurrent miscarriage and pre-conceptional supplementation with vitamin B12 might be beneficial to improve pregnancy outcome.

  7. Recurrences of Bell's palsy.

    Science.gov (United States)

    Cirpaciu, D; Goanta, C M; Cirpaciu, M D

    2014-01-01

    Bell's palsy in known as the most common cause of facial paralysis, determined by the acute onset of lower motor neuron weakness of the facial nerve with no detectable cause. With a lifetime risk of 1 in 60 and an annual incidence of 11-40/100,000 population, the condition resolves completely in around 71% of the untreated cases. Clinical trials performed for Bell's palsy have reported some recurrences, ipsilateral or contralateral to the side affected in the primary episode of facial palsy. Only few data are found in the literature. Melkersson-Rosenthal is a rare neuromucocutaneous syndrome characterized by recurrent facial paralysis, fissured tongue (lingua plicata), orofacial edema. We attempted to analyze some clinical and epidemiologic aspects of recurrent idiopathic palsy, and to develop relevant correlations between the existing data in literature and those obtained in this study. This is a retrospective study carried out on a 10-years period for adults and a five-year period for children. A number of 185 patients aged between 4 and 70 years old were analyzed. 136 of them were adults and 49 were children. 22 of 185 patients with Bell's palsy (12%) had a recurrent partial or complete facial paralysis with one to six episodes of palsy. From this group of 22 cases, 5 patients were diagnosed with Melkersson-Rosenthal syndrome. The patients' age was between 4 and 70 years old, with a medium age of 27,6 years. In the group studied, fifteen patients, meaning 68%, were women and seven were men. The majority of patients in our group with more than two facial palsy episodes had at least one episode on the contralateral side. Our study found a significant incidence of recurrences of idiopathic facial palsy. Recurrent idiopathic facial palsy and Melkersson-Rosenthal syndrome is diagnosed more often in young females. Recurrence is more likely to occur in the first two years from the onset, which leads to the conclusion that we should have a follow up of patients

  8. Effect of ventilation on concentrations of indoor radon- and thoron-progeny: Experimental verification of a simple model

    International Nuclear Information System (INIS)

    Sheets, R.W.; Thompson, C.C.

    1993-01-01

    Different models relating the dependence of radon ( 222 Rn)- and thoron ( 220 Rn)-progeny activities on room ventilation rates are presented in the literature. Some of these models predict that, as the rate of ventilation increases, activities of thoron progeny decrease more rapidly than those of radon progeny. Other models predict the opposite trend. In this study alpha activities of the radon progeny, 218 Po, 214 Pb, and 214 Bi, together with the thoron progeny 212 Pb, were measured over periods of several days in two rooms of a closed, heated house. Effective ventilation rates were calculated from measured 214 Pb/ 214 Bi ratios. A simple model in which progeny concentrations decrease by radioactive decay and by dilution with outside air has been used to calculate 212 Pb/ 214 Pb ratios as a function of ventilation rate. Calculated ratios are found to correlate significantly with experimentally-determined ratios (R 2 ∼ 0.5--0.8 at p < 0.005) confirming that, for this house, thoron progeny activities decrease faster than radon progeny activities with increasing rates of ventilation

  9. Growth and Crown Vigor of 25 Year-Old Shortleaf Pine Progenies on a Littleleaf Disease Site

    Science.gov (United States)

    Stanley J. Zarnoch; John L. Ruehle; Roger P. Belanger; Donald H. Marx; W. Craig Bryan

    1994-01-01

    On a littleleaf disease site in South Carolina, most of the control-pollinated progeny of shrotleaf pines that appeared to be reesistant to the disease outperformed a check seedlot through age 25. Rankings of progeny based on volume changed little between ages 17 and 25.

  10. Development of calibration facility for radon and its progenies at NIM (China)

    International Nuclear Information System (INIS)

    Liang, J.C.; Liu, H.R.; Zhang, M.; Zheng, P.H.; Guo, Q.J.; Yang, Z.J.; Li, Z.S.; Zhang, L.

    2015-01-01

    Accurate measurement of radon and its progenies is the basis to control the radon dose and reduce the risk of lung cancer caused. The precise calibration of measuring instrument is an important part of the quality control of measurements of the concentration of radon and radon progenies. To establish Chinese national standards and realise reliable calibrations of measuring instrument for radon and its progenies, a radon chamber with regulation capability of environmental parameters, aerosol and radon concentrations was designed and constructed at National Institute of Metrology (NIM). The chamber has a total volume of ∼20 m 3 including an exposure volume of 12.44 m 3 . The radon concentration can be controlled from 12 Bq m -3 to the maximum of 232 kBq m -3 . The regulation range of temperature, relative humidity and aerosol are 0.66-44.39 deg. C, 16.4-95 %RH and 10 2 -10 6 cm -3 , respectively. The main advantages of the NIM radon chamber with respect to maintaining a stable concentration and equilibrium factor of radon progenies in a wide range through automatic regulation and control of radon and aerosol are described. (authors)

  11. Maternal Transfer of Vitamin C in Channel Catfish (Ictalurus Punctatus) Effects Reproduction and Progeny Performance

    Science.gov (United States)

    Two routes of maternal transfer of vitamin C in channel catfish female broodfish prior to spawning were explored as a strategy to incorporate the vitamin to determine its effect on reproduction and subsequent performance of the progeny. Accumulation of vitamin C was higher (p<0.05) in ovarian tissu...

  12. Repeatability of number of progeny born to bulls used in group mating of cows

    Science.gov (United States)

    The group mating of bulls in pasture situations is a management practice that might be more efficient if an individual bull’s ability to sire calves could be predicted. Retrospective data on numbers of progeny born to bulls from 4 populations (Angus and 3 composite breeds) in 4 consecutive years of...

  13. Indoor radon progeny aerosol size measurements in urban, suburban, and rural regions

    International Nuclear Information System (INIS)

    Tu, K.W.; Knutson, E.O.; George, A.C.

    1991-01-01

    By using direct and indirect methods, the authors conducted size distribution measurements of radon progeny particles in a variety of indoor environments in urban, suburban, and rural areas. The radon progeny particle size distribution owing to indoor activities has two definable source categories: (1) gas combustion from stoves and kerosene heaters - particles were found to be smaller than 0.1 μm in diameter, mostly in the range 0.02-0.08 μm; and (2) cigarette smoking and food frying - particles were found to be larger, in the size range 0.1-0.2 μm. The radon progeny particle size distribution, without significant indoor activities, such as cooking, was found to be larger in rural areas than in urban or suburban areas. The modal diameters of the size spectra in the rural areas were two to three times larger than those in urban or suburban areas, around 0.3-0.4 bs. 0.1-0.2 μm. Results obtained by applying the attachment theory to the measured number-weighted size spectra from an electrical aerosol size analyzer support this finding. These results, if confirmed by more extensive studies, will be useful for the assessment of the risk from the inhalation of radon progeny in various indoor environments

  14. Dietary manipulation of the sow milk does not influence the lipid absorption capacity of the progeny

    DEFF Research Database (Denmark)

    Lauridsen, Charlotte; Hedemann, Mette Skou; Pierzynowski, Stefan

    2007-01-01

    A control diet without supplemental fat and four diets containing 8% of coconut oil, rapeseed oil, fish oil or sunflower oil were fed to lactating sows in order to investigate the lipid absorption capacity of their progeny in terms of pancreatic enzyme activity, hormonal regulation, and bile salt...

  15. Design of a recirculating radon progeny aerosol generation and animal exposure system

    International Nuclear Information System (INIS)

    Newton, G.J.; Cuddihy, R.G.; Yeh, H.C.; Barr, E.B.; Boecker, B.B.

    1988-01-01

    Inhalation studies are being conducted at ITRI using laboratory animals exposed to radon-222 progeny attached to vector aerosols that are typical of indoor environments. The purpose of these studies is to identify the cells at risk from inhaled radon progeny and their locations within the respiratory tract. These studies require exposures up to 1000 working level months (WLM) within a few hours. Thus, large amounts of radium-226 are needed to produce the gaseous radon-222. A once-through-exposure-system was considered to be impractical because of statutory discharge limitations and the large amounts of radium that would be required. Therefore, a recirculating exposure system was designed and constructed that removes the aerosol after passing through the exposure chambers and recirculates purified air and radon. The purified radon is mixed with freshly evolving radon from a radon generator and passed Into a reaction-aging chamber where attachment of radon progeny to the vector aerosol occurs. The design includes: (1) 50-200 mg radium-226 in a radon generator, (2) 40 L/min total flow rate, (3) CO 2 removal, (4) reconstitution of oxygen tension and water vapor content to atmospheric levels, and (5) a trap for radon gas. A radon progeny exposure concentration in the range of 4,000 to 50,000 WL is being produced. (author)

  16. Development of an aerosol chamber for calibration of 220Rn progeny detectors

    Science.gov (United States)

    Sorimachi, Atsuyuki; Ishikawa, Tetsuo; Tokonami, Shinji

    2014-09-01

    This paper describes an aerosol chamber system that can be used for calibrations and performance experiments of passive 220Rn progeny detectors. For the purpose of this study, an aerosol generation system using carnauba wax as the aerosol material was mounted into the 220Rn chamber. We used the chamber to measure characteristics of the equilibrium factor (F) of 220Rn and unattached fraction (fp) of 220Rn progeny, which are important parameters for dose estimation. The first experiment showed that continuous and stable generation of the unattached and aerosol-attached 220Rn progeny concentrations was obtained. We observed that the spatial distributions in the chamber of the vertical profiles of the unattached and aerosol-attached 220Rn progeny concentrations were homogeneous, as were the particle number concentration and count median diameter. The values of F and fp and their characteristics observed in this study were in the same range as the values reported from indoor measurements. We found that the characteristics of F and fp were dependent on the aerosol conditions (particle diameter and particle number concentration).

  17. The postnatal progeny development of males whose sexual cells were irradiated during different stages of spermatogenesis

    International Nuclear Information System (INIS)

    Lepekhin, N.P.; Palyga, G.F.

    1995-01-01

    Distinct genetic radiosensitivity if germinal cells of males irradiated during different stages of spermatogenesis with doses of 0.25-5.0 Gy leads to reduction in vital newborn rats number in the first generation progeny and to elevated postnatal mortality rate. These postnatal ontogeny disorders depend on the irradiation dose and spermatogenesis stage for a moment irradiation. 11 refs.; 4 tabs

  18. Past as Prologue: Educational Psychology's Legacy and Progeny

    Science.gov (United States)

    Alexander, Patricia A.

    2018-01-01

    On the occasion of the 125th anniversary of the American Psychological Association, the legacies and progenies of the discipline of educational psychology are explored. To capture those legacies, transformational and influential contributions by educational psychologists to schools and society are described as key themes. Those themes entail: the…

  19. Control methods of radon and its progeny concentration in indoor atmosphere

    International Nuclear Information System (INIS)

    Ramachandran, T.V.; Subba Ramu, M.C.

    1990-01-01

    Exposure to radon-222 and its progeny in indoor atmosphere can result in significant inhalation risk to the population particularly to those living in houses with much higher levels of Rn. There are three methods generally used for the control of Rn and its progeny concentration in the indoor environment: (1) restricting the radon entry, (2) reduction of indoor radon concentration by ventilation or by aircleaning and (3) removal of airborne radon progeny by aerosol reduction. Prominent process of radon entry in most of the residence appears to be the pressure driven flow of soil gas through cracks or through other openings in the basements slab or subfloor. Sealing off these openings or ventilation of the slab or subfloor spaces are the methods of reducing the radon entry rate. Indoor radon progeny levels can also be reduced by decreasing the aerosol load in the dwellings. The results of a few experiments carried out to study the reduction in the working level concentration of radon, by decreasing the aerosol load are discussed in this paper. (author). 9 tabs., 8 figs., 37 refs

  20. Risk of lung cancer in animals following low exposures to Radon-222 progeny

    International Nuclear Information System (INIS)

    Duport, P.; Monchaux, G.; Morlier, J.P.

    1997-01-01

    Owing to the facts that a) large uncertainties affect the epidemiology of radon progeny-induced lung cancer in humans (especially at low exposures), and b) the rat is a good model for studying the carcinogenicity of radon progeny in humans, the risk of lung cancer following low exposures to low concentrations of radon progeny can be estimated from data obtained in the laboratory on rats exposed under controlled conditions. From the limited set of laboratory data on the induction of lung cancer in laboratory rats it appears that, at low exposures, the risk of lung cancer decreases with decreasing concentration, and that exposures of the order of 25 WLM, at an exposure rate of 2 WL do not produce any excess lung cancers. Since 20 WLM is a lifetime exposure comparable to those expected in occupational or indoors conditions and 2 WL is an exposure rate about 20 times higher dm current occupational exposures rates and 100 times higher than indoor ones, these observations may be indicative of threshold conditions for the induction of lung cancer by radon progeny. (author)

  1. Prediction of lung cells oncogenic transformation for induced radon progeny alpha particles using sugarscape cellular automata.

    Science.gov (United States)

    Baradaran, Samaneh; Maleknasr, Niaz; Setayeshi, Saeed; Akbari, Mohammad Esmaeil

    2014-01-01

    Alpha particle irradiation from radon progeny is one of the major natural sources of effective dose in the public population. Oncogenic transformation is a biological effectiveness of radon progeny alpha particle hits. The biological effects which has caused by exposure to radon, were the main result of a complex series of physical, chemical, biological and physiological interactions. The cellular and molecular mechanisms for radon-induced carcinogenesis have not been clear yet. Various biological models, including cultured cells and animals, have been found useful for studying the carcinogenesis effects of radon progeny alpha particles. In this paper, sugars cape cellular automata have been presented for computational study of complex biological effect of radon progeny alpha particles in lung bronchial airways. The model has included mechanism of DNA damage, which has been induced alpha particles hits, and then formation of transformation in the lung cells. Biomarkers were an objective measure or evaluation of normal or abnormal biological processes. In the model, the metabolism rate of infected cell has been induced alpha particles traversals, as a biomarker, has been followed to reach oncogenic transformation. The model results have successfully validated in comparison with "in vitro oncogenic transformation data" for C3H 10T1/2 cells. This model has provided an opportunity to study the cellular and molecular changes, at the various stages in radiation carcinogenesis, involving human cells. It has become well known that simulation could be used to investigate complex biomedical systems, in situations where traditional methodologies were difficult or too costly to employ.

  2. Frequency of Aneuploids in Progenies of Autotriploid Barley, Hordeum Vulgare L

    DEFF Research Database (Denmark)

    Sandfær, J.

    1979-01-01

    Chromosome counts of 863 progeny plants originating from 68 autotriploid barley plants revealed a considerable variation in chromosome numbers ranging from the diploid number (2n= 14) to 2n= 39. The most frequent groups were plants with 15 and 16 chromosomes each constituting about 27% of all pro...

  3. Chemical segregation of progeny of camphor trees with high camphor c.q. Linalool content

    NARCIS (Netherlands)

    Khien, P.V.; Chien, Ho Trung; Dung, N.X.; Leclercq, A.X.; Leclercq, P.A.

    1998-01-01

    The propagation of open pollinated seed from two camphor trees with a high camphor and linalool content, respectively, yielded 115 progeny. The chemical composition of the leaf oils of these trees was analyzed by a combination of capillary GC and GC/MS. Four chemotypes could be distinguished among

  4. Aubergine Controls Germline Stem Cell Self-Renewal and Progeny Differentiation via Distinct Mechanisms.

    Science.gov (United States)

    Ma, Xing; Zhu, Xiujuan; Han, Yingying; Story, Benjamin; Do, Trieu; Song, Xiaoqing; Wang, Su; Zhang, Ying; Blanchette, Marco; Gogol, Madelaine; Hall, Kate; Peak, Allison; Anoja, Perera; Xie, Ting

    2017-04-24

    Piwi family protein Aubergine (Aub) maintains genome integrity in late germ cells of the Drosophila ovary through Piwi-associated RNA-mediated repression of transposon activities. Although it is highly expressed in germline stem cells (GSCs) and early progeny, it remains unclear whether it plays any roles in early GSC lineage development. Here we report that Aub promotes GSC self-renewal and GSC progeny differentiation. RNA-iCLIP results show that Aub binds the mRNAs encoding self-renewal and differentiation factors in cultured GSCs. Aub controls GSC self-renewal by preventing DNA-damage-induced Chk2 activation and by translationally controlling the expression of self-renewal factors. It promotes GSC progeny differentiation by translationally controlling the expression of differentiation factors, including Bam. Therefore, this study reveals a function of Aub in GSCs and their progeny, which promotes translation of self-renewal and differentiation factors by directly binding to its target mRNAs and interacting with translational initiation factors. Copyright © 2017 Elsevier Inc. All rights reserved.

  5. Genetic variation in dieback resistance in Fraxinus excelsior confirmed by progeny inoculation assay

    DEFF Research Database (Denmark)

    Lobo, Albin; McKinney, Lea Vig; Hansen, Jon Kehlet

    2015-01-01

    from low susceptible mother clones developed smaller necroses when compared to offspring from susceptible clones. Their crown damage due to natural infections was also significantly less. The correlation coefficient between average crown damages of mother clones and the average of their progeny was 0...

  6. Genetic diversity analysis of brassica napus/brassica campestris progenies using microsatellite markers

    International Nuclear Information System (INIS)

    Fayyaz, L.; Farhatullah, A.; Iqbal, S.; Kanwal, M.; Nawaz, I.

    2014-01-01

    Genetic diversity and relationship of F2 segregating progenies of interspecific crosses between B. napus N-501/B. campestris C-118 were studied. A set of 90 genotypes (2 parental lines and their 88 F2 progenies) was characterized separately using 24 microsatellite or SSR markers to cover the diversity as broadly as possibly present in them. In initial screening only 12 out of 24 SSR primers combination amplified DNA fragments, while the remaining 12 SSR primers did not amplify DNA fragment therefore those 12 SSR molecular markers were not used for further analysis. The 12 SSR primer combinations generated a total of 33 alleles, of that 32 were polymorphic loci, whereas only one was monomorphic locus. Primers BRMS-19 and BRMS-40 were highly polymorphic producing 4 bands each. Primer Ra2-D04 was less polymorphic and it produced only one band. The proportion of polymorphic loci was 95.83% which indicates high genetic diversity among the progenies. The average number of polymorphic alleles per locus was 2.66. The PIC values ranged from 0.395 for primer Ra2-E03 to 0.726 for primer BRMS-019 with an average genetic diversity (PIC value) of 0.584 per locus. Seven primers showed PIC values above 0.5 (50%) indicating high genetic diversity in the studied plant materials. Pair-wise similarity indices among 90 genotypes ranged from 0.3 to 0.95. Dendrogram obtained through UPGMA clustering of F2 progenies depicted eight main groups using similarity coefficient of 0.70. The progenies could be similar to their parents if they have the same banding patterns as that of the parents and could be distinguished from each other by the combination of fragments which are repeatedly present in one progeny and absent in the other. Considerable genetic diversity has been found among the F2 segregating progenies and their parents using SSR markers thus, SSR analysis proved to be a useful tool. (author)

  7. Recurrent parotitis in children

    Directory of Open Access Journals (Sweden)

    Bhattarai M

    2006-01-01

    Full Text Available Recurrent parotitis is an uncommon condition in children. Its etiological factors have not been proved till date although causes due to genetic inheritance, local autoimmune manifestation, allergy, viral infection and immunodeficiency have been suggested. The exact management of this disorder is not yet standardized, but a conservative approach is preferred and all affected children should be screened for Sjogren′s syndrome and immune deficiency including human immunodeficiency virus. We report a 12 years female child who presented with 12 episodes of non-painful recurrent swellings of the bilateral parotid gland in the past 3 years.

  8. Recurrent atrial myxoma.

    Science.gov (United States)

    Macarie, C; Stoica, E; Chioncel, O; Carp, A; Gherghiceanu, D; Stiru, O; Zarma, L; Herlea, V

    2004-01-01

    We have chosen this case of sporadic atrial myxoma for our presentation because it had a particular evolution, with recurrence at 8 years after surgical excision (echocardiography was performed every year) and a particular diagnostic means - at echocardiographic follow-up, the patient being asymptomatic. This presentation, together with a review of literature included in the article, emphasizes the importance of a careful postoperative follow-up of the patients and the existence of some particular aspects of the evolution and symptomatology of recurrent atrial myxoma.

  9. Temporal and vertical variations radon and its progeny related to atmospheric electrical conductivity

    International Nuclear Information System (INIS)

    Pruthvi Rani, K.S.; Chandrashekara, M.S.; Paramesh, L.

    2015-01-01

    Atmospheric radon, its progeny, electrical conductivity and meteorological parameters such as wind, temperature, humidity, pressure and rainfall were continuously monitored during 2012 to 2014 at one location in Mysuru city. The annual mean atmospheric radon concentration at the study location was found to be 16.4 Bqm -3 . The diurnal cycle of radon and its progeny show a peak in the early morning hours followed by a drastic decrease after sunrise and rising to a second peak in the afternoon. It was found that the stability of the atmosphere and ambient temperature played a major role in the diurnal variations. Higher concentrations of radon and its progeny were observed in winter and lower values in summer. This may due to the variations in origin of air mass and meteorological parameters. Wind direction analyses reveal that in sectors with air which has spent a longer period over the granitic region and low wind speeds will lead to higher concentrations of radon. Atmospheric electrical conductivity near the ground is mainly due to the ionization from radon and its progeny. The diurnal variations of conductivity and ionization rate due to radon and its individual progeny were of similar trend. In addition its significant dependence on meteorological parameters is confirmed. The vertical variations of atmospheric electrical conductivity were studied at different heights up to 250 m from the ground level. Higher values were observed close to the ground surface, there was a rapid reduction up to about 10 m and beyond that the conductivity gradually decreases. The diurnal conductivity cycle is studied at 10 m and 100 m showed the expected similar trend at both the heights but early morning maxima were considerably different, this confirms the accumulation of radon gas close to the ground surface during night time leading to increase of conductivity values. (author)

  10. Radon and thoron progeny levels in air samples at Udagamandalam region of Nilgiris in India

    International Nuclear Information System (INIS)

    Manikandan, N.M.; Selvasekarapandian, S.; Sivakumar, R.; Raghunath, V.M.; Sundaram, V.M.; Santhanam, S.

    2002-01-01

    Measurement of concentration of radon and thoron daughter products in various indoor environment covering four seasons of a year in Udagamandalam Taluk of Nilgiris biosphere has been carried out using a high volume air sampler to assess the inhalation dose to the population which delivers higher dose than the radon and thoron gas alone. The potential alpha-energy concentrations of the radon and thoron progeny ranged from 0.97 to 12.72 mWL and from 1.63 to 15.83 mWL with a geometric mean of 6.02 and 7.89 mWL, respectively, taking all seasons into account. These measurements have yielded a wealth of data on the variation among the indoor radon and thoron progeny in various places during different seasons. The radon and thoron progeny levels are higher in winter seasons and are less in summer season with autumn and spring data lie in between winter and summer. Using the dose conversion factor for indoor exposures given in UNSCEAR 93 report the internal equivalent dose to the inhalation of radon progeny is evaluated to be 1357 μSv x y -1 and the corresponding annual effective dose equivalent value has been found to be 2.13 mSv x y -1 . It can be observed that the mean value of radon is higher than the Indian average. Also it is found the radon and thoron progeny levels are higher in the case of houses built with rock and granite and in tiled type houses of nearly 100 years old. The levels are less in the case of houses built with brick and cement. The observed results for different types of houses and seasons are discussed in this paper. (author)

  11. Rearing and gamma radiation effects on mature pupae of pink bollworm and their F1 progeny

    International Nuclear Information System (INIS)

    Qureshi, Z.A.; Ahmed, N.; Hussain, T.

    1993-01-01

    Pink bollworm larvae were successfully reared in captivity on a casein wheat germ diet. The substitution of casein with soyflour, corn-cob grit and wheat germ, and casein for peanut flour, resulted in delayed development, reduced pupal recovery and fecundity of the adult moths. This reduction was more drastic in corn-cob grit and peanut flour diets. The irradiation of mature pupae at 50-200 Gy resulted in decreased adult emergence with increased gamma radiation doses, and more deformed moths were recorded at a dose of 200 Gy. Adults following irradiation of mature pupae when crossed with untreated males or females or treated individuals crossed to treated exhibited reduced fecundity and fertility with the increasing doses. This reduction was more pronounced when treated males were crossed with treated females. Females were relatively more sensitive to gamma radiation, as a reduced number of eggs was obtained when treated females were crossed with untreated males. At 200 Gy, no F 1 progeny were obtained from any cross involving treated parents. The fecundity and fertility were reduced significantly when F 1 males or F 1 females from male parents irradiated as mature pupae were mated with untreated insects at both 100 and 150 Gy. However, inherited sterility was more pronounced when F 1 males were crossed with untreated females than when F 1 females were crossed with untreated males. Similarly reduced fecundity and fertility in F 1 progeny from female parents irradiated as mature pupae, both at 100 and 150 Gy, were also recorded in crosses as described for male F 1 progeny. The fecundity and fertility were the lowest in F 1 progeny of both male and female parents irradiated as mature pupae when compared with the F 1 progeny of male or female irradiated parents separately. (author). 28 refs, 7 tabs

  12. Surgical management of malignant bowel obstruction in recurrent pancreatic cancer

    Directory of Open Access Journals (Sweden)

    Hyung Sun Kim

    2017-01-01

    Discussion and conclusion: Palliative surgery improves quality of life in recurrent pancreatic cancer patients and can continue patient’s palliative management. In selected patients, palliative surgery may effective management for progress of survival and quality of life.

  13. Laparoscopic Surgery for Recurrent Crohn's Disease

    Directory of Open Access Journals (Sweden)

    Antonino Spinelli

    2012-01-01

    Full Text Available In spite of the recent improvements in drug therapy, surgery still represents the most frequent treatment for Crohn's disease (CD complications. Laparoscopy has been widely applied over the last twenty years in colorectal surgery and was associated with lower postoperative pain, shorter hospitalization, faster return to daily activities, and better cosmetic results. Laparoscopy experienced a slower diffusion in inflammatory bowel disease surgery than in oncologic colorectal surgery, but proved to be safe and effective, and is currently considered the gold standard for the treatment of primary uncomplicated ileocolic CD. Indications for laparoscopy in CD have recently been widened to embrace more complicated or recurrent CD. This paper reviews the available data on the subset of recurrent CD patients. The reported results indicate that laparoscopy may be safely applied even in selected recurrent CD cases in hands of IBD surgeons with broad laparoscopic experience.

  14. Lung Cancer Indicators Recurrence

    Science.gov (United States)

    This study describes prognostic factors for lung cancer spread and recurrence, as well as subsequent risk of death from the disease. The investigators observed that regardless of cancer stage, grade, or type of lung cancer, patients in the study were more

  15. Recurrent diabetic ketoacidosis

    DEFF Research Database (Denmark)

    Skinner, T. Chas

    2002-01-01

    Longitudinal studies indicate that 20% of paediatric patients account for 80% of all admissions for diabetic ketoacidosis (DKA). The frequency of DKA peaks during adolescence and, although individuals generally go into remission, they may continue to have bouts of recurrent DKA in adulthood. The ...

  16. Recurrent infantile digital fibromatosis

    African Journals Online (AJOL)

    We present a case of an 8-year-old-boy with recurrent infantile digital fibromatosis (IDF) who presented with new ... Keywords: fibrous tumors, inclusion body fibromatosis, infantile digital fibromatosis, spindle cells, Reye tumor .... watch-and-wait strategy for patients with histologically confirmed IDF nodules that do not cause ...

  17. On Solving Linear Recurrences

    Science.gov (United States)

    Dobbs, David E.

    2013-01-01

    A direct method is given for solving first-order linear recurrences with constant coefficients. The limiting value of that solution is studied as "n to infinity." This classroom note could serve as enrichment material for the typical introductory course on discrete mathematics that follows a calculus course.

  18. Hybrid Weakness Found in the Backcross Progeny of an Inter-Specific Cross of Oryza Sativa / O. Glumaepatula

    Directory of Open Access Journals (Sweden)

    Sobrizal

    2009-01-01

    Full Text Available Hybrid breakdown expressed as sterility or weakness or both in F2 or later generations is considered to be a reproductive barrier between two distantly related taxa. Hybrid breakdown that showed poor growth habit with fertile seeds was found in the backcross progenies (BC4F2 which were derived from a cross between a cultivated rice Oryza sativa L. cv. Taichung 65 and a wild rice Oryza glumaepatula Steud (Acc. IRGC 105668 where Taichung 65 was used as a recurrent parent. Through segregation analysis of BC4F2 population, a novel gene for weakness was identified, and this gene was designated as hwf1 (hybrid weakness f-1. RFLP (Restriction Fragment Length Polymorphism analysis was employed to determine the chromosomal location of hwf1 gene. The result revealed that hwf1 was located between G3006 and C933 RFLP markers, with map distances of 0.5 cM and 1.9 cM, respectively, and co-segregated with C708, C820, and R288 on the short arm of chromosome 4. Since both O. glumaepatula (Acc. IRGC 105668 and Taichung 65 that was used as parents showed normal growth habit, the weakness in this study was assumed to be controlled by a set of complementary recessive genes. One of the complementary genes is hwf1 from O. glumaepatula, and another gene should be from Taichung 65, because the genetic background of the BC4F2 populations that were used for analysis is Taichung 65. The gene from Taichung 65 has not been identified yet, therefore, it is necessary to conduct the experiment for finding out the complement of hwf1 gene in near future.

  19. Hybrid Weakness Found In the Backcross Progeny of an Inter-Specific Cross of Oryza Sativa / O. Glumaepatula

    International Nuclear Information System (INIS)

    Sobrizal; Yoshimura, A

    2009-01-01

    Hybrid breakdown expressed as sterility or weakness or both in F 2 or later generations is considered to be a reproductive barrier between two distantly related taxa. Hybrid breakdown that showed poor growth habit with fertile seeds was found in the backcross progenies (BC 4 F 2 ) which were derived from a cross between a cultivated rice Oryza sativa L. cv. Taichung 65 and a wild rice Oryza glumaepatula Steud (Acc. IRGC 105668) where Taichung 65 was used as a recurrent parent. Through segregation analysis of BC 4 F 2 population, a novel gene for weakness was identified, and this gene was designated as hwf1 (hybrid weakness f-1). RFLP (Restriction Fragment Length Polymorphism) analysis was employed to determine the chromosomal location of hwf1 gene. The result revealed that hwf1 was located between G3006 and C933 RFLP markers, with map distances of 0.5 cM and 1.9 cM, respectively, and co-segregated with C708, C820, and R288 on the short arm of chromosome 4. Since both O. glumaepatula (Acc. IRGC 105668) and Taichung 65 that was used as parents showed normal growth habit, the weakness in this study was assumed to be controlled by a set of complementary recessive genes. One of the complementary genes is hwf1 from O. glumaepatula, and another gene should be from Taichung 65, because the genetic background of the BC 4 F 2 populations that were used for analysis is Taichung 65. The gene from Taichung 65 has not been identified yet, therefore, it is necessary to conduct the experiment for finding out the complement of hwf1 gene in near future. (author)

  20. Intra-specific variations in expression of stress-related genes in beech progenies are stronger than drought-induced responses.

    Science.gov (United States)

    Carsjens, Caroline; Nguyen Ngoc, Quynh; Guzy, Jonas; Knutzen, Florian; Meier, Ina Christin; Müller, Markus; Finkeldey, Reiner; Leuschner, Christoph; Polle, Andrea

    2014-12-01

    Rapidly decreasing water availability as a consequence of climate change is likely to endanger the range of long-lived tree species. A pressing question is, therefore, whether adaptation to drought exists in important temperate tree species like European beech (Fagus sylvatica L.), a wide-spread, dominant forest tree in Central Europe. Here, five beech stands were selected along a precipitation gradient from moist to dry conditions. Neutral genetic markers revealed strong variation within and little differentiation between the populations. Natural regeneration from these stands was transferred to a common garden and used to investigate the expression of genes for abscisic acid (ABA)-related drought signaling [9-cis-epoxy-dioxygenase (NCED), protein phosphatase 2C (PP2C), early responsive to dehydration (ERD)] and stress protection [ascorbate peroxidase (APX), superoxide dismutase (SOD), aldehyde dehydrogenase (ALDH), glutamine amidotransferase (GAT)] that are involved in drought acclimation. We hypothesized that progenies from dry sites exhibit constitutively higher expression levels of ABA- and stress-related genes and are less drought responsive than progenies from moist sites. Transcript levels and stress responses (leaf area loss, membrane integrity) of well-irrigated and drought-stressed plants were measured during the early, mid- and late growing season. Principal component (PC) analysis ordered the beech progenies according to the mean annual precipitation at tree origin by the transcript levels of SOD, ALDH, GAT and ERD as major loadings along PC1. PC2 separated moist and drought treatments with PP2C levels as important loading. These results suggest that phosphatase-mediated signaling is flexibly acclimated to the current requirements, whereas stress compensatory measures exhibited genotypic variation, apparently underlying climate selection. In contrast to expectation, the drought responses were less pronounced than the progeny-related differences and the

  1. Coping with Fear of Recurrence

    Science.gov (United States)

    ... What Comes Next After Finishing Treatment Coping With Fear of Recurrence Having a Baby After Cancer: Pregnancy ... treatment and preparing for the future. Coping With Fear of Recurrence Learn ways to manage the fear ...

  2. Assessment of dose due to exposure to indoor radon and thoron progeny

    Directory of Open Access Journals (Sweden)

    Prasad Ganesh

    2010-01-01

    Full Text Available The components of the effective dose through inhalation from radon and its progeny are important for human health since they contribute to more than 50% of the total radiation dose from natural sources. As a consequence, radon has been identified as the second leading cause of lung cancer after smoking. Radon and its short lived decay products (218Po, 214Pb, 214Bi, 214Po present in dwellings are a radiation hazard, particularly if such sources are concentrated in the enclosed areas like poorly ventilated houses and underground mines. The indoor radon, thoron, and progeny concentrations were measured in a small hilly town of Budhakedar and the surrounding area of Tehri Garhwal, India, by using LR-115 Type II plastic track detector in a twin cup radon dosimeter. The concentrations of radon progeny were measured as the highest in winter and the lowest in summer while the thoron progeny concentration was found maximum in rainy season and minimum in autumn. The annual exposure to the potential alpha energy of radon and thoron were found to vary from 0.04 WLM to 0.69 WLM with an average value of 0.29 WLM, and 0.03 WLM to 0.37 WLM with an aver- age value of 0.16 WLM, respectively. The annual effective dose due to the exposure to indoor radon and progeny in Budhakedar homes was found to vary from 0.16 mSv to 2.72 mSv with an average value of 1.14 mSv and the effective dose due to the exposure to thoron and progeny was found to vary from 0.18 mSv to 2.49 mSv with an average value of 1.05 mSv. The results of systematic study have been obtained by considering the room as a space in which the radon and thoron levels are directly related to the dynamic and static parameters.

  3. Chaotic diagonal recurrent neural network

    International Nuclear Information System (INIS)

    Wang Xing-Yuan; Zhang Yi

    2012-01-01

    We propose a novel neural network based on a diagonal recurrent neural network and chaos, and its structure and learning algorithm are designed. The multilayer feedforward neural network, diagonal recurrent neural network, and chaotic diagonal recurrent neural network are used to approach the cubic symmetry map. The simulation results show that the approximation capability of the chaotic diagonal recurrent neural network is better than the other two neural networks. (interdisciplinary physics and related areas of science and technology)

  4. THE SEGREGATION PATTERN OF INSECT RESISTANCE GENES IN THE PROGENIES AND CROSSES OF TRANSGENIC ROJOLELE RICE

    Directory of Open Access Journals (Sweden)

    Satoto Satoto

    2016-10-01

    Full Text Available Successful application of genetic transformation technique, especially in developing rice variety resistant to brown plant hopper and stem borer, will depend on transgene being expressed and the gene inherited in a stable and predictable manner. This study aimed to analyse transgene segregation pattern of the progenies and the crosses of transgenic rice cv. Rojolele harboring cry1Ab and gna genes. The third generation (T2 of fivetransgenic Rojolele events containing gna and/or cry1Ab were evaluated for two generations to identify the homozygous lines and to study their inheritance. The homozygous lines were selected based on the result of PCR technique. The segregation patterns of gna and cry1Ab were studied in eight F2 populations derived from Rojolele x transgenic Rojolele homozygous for cry1Ab and or gna and their reciprocal crosses. Data  resulted from PCR of F2 population were analysed using a Chi Square test. The study obtained six homozygous lines for gna, namely A22- 1-32, A22-1-37, C72-1-9, F11-1-48, K21-1-39, K21-1-48, and two homozygous lines for cry1Ab, namely K21-1-39 and K21- 1-48. Both cry1Ab and gna transgenes had been inherited through selfing and crossing with their wild type as indicated from the F1 containing gna and cry1Ab as many as 48.4% and 47.4%, respectively. In six of the eight crosses, gna was inherited in a 3:1 ratio consistent with Mendelian inheritance of a single dominant locus, while in the remaining two crosses, gna was segregated in a 1:1 ratio. The presence of cry1Ab in F2 populations also showed a 3:1 segregation ratio in all crosses. In the F2 population derived from F1 plant containing cry1Ab and gna, both transgenes segregated in a 9:3:3:1 dihybrid segregation ratio. This study will add to the diversity of genetic sources for insect resistance and allow further use of these transgenic lines for pyramiding resistance to brown plant hopper and stem borer or  separately in rice breeding programs whenever

  5. Broiler performance, hatching egg, and age relationships of progeny from standard and dwarf broiler dams.

    Science.gov (United States)

    Tahir, M; Cervantes, H; Farmer, C W; Shim, M Y; Pesti, G M

    2011-06-01

    The relationship of egg and chick weights to the performance of broiler chickens from two 42-wk-old flocks (standard and dwarf dams) having male parents from the same genetic stock was investigated in this study. Fertility (91.7 vs. 94.7%) and hatchability (95.2 vs. 96.3%) were not significantly (P > 0.10) different for eggs from standard and dwarf dams, respectively. Egg weight contributed significantly to the variation in BW [BW = β(0) + β(i) (egg weight) + β(i) (dam) + β(i) (sex)]. Body weight as a function of chick weight was not significant. However, chick weight was significant when included in a model with egg weight, suggesting that significant differences in BW at 50 d could be attributed to both egg and chick weights. The negative coefficient for chick weight indicated that between the 2 broilers of the same egg weight, the one with the greater chick weight would have the smaller 50-d BW. Chick weight was a linear function of egg weight. Similarly, the effect of egg or chick weight on broiler BW at 35 or 50 d was best represented by a single linear function. Dam genotype did not contribute significantly to variation in 50-d BW after variation attributable to egg weight was removed from the model. Differences in BW attributable to egg weight increased with broiler age. The coefficients of egg weight and chick weight showed that the differences in BW per gram of egg were 1.43, 3.06, 6.24, and 7.61 g and those per gram of chick were 1.87, 3.99, 8.14, and 9.93 g, respectively, at 7, 21, 35, and 50 d. Body weight increased by 0.1563 times egg weight (and 0.2092 times chick weight) with each additional day of age for both sexes and genotypes. Clearly, both egg and chick weights are important for modeling or predicting market-age broiler BW and economic returns. The relatively small relationship between BW and egg weight demonstrates that genetic selection over the past 3 decades has decreased the influence of egg weight on broiler growth. The present dwarf

  6. Causes of recurrent pneumonia in children in a general hospital.

    Science.gov (United States)

    Hoving, M F Paulien; Brand, Paul L P

    2013-03-01

    Because the few previous studies on underlying causes of recurrent pneumonia in children have come from tertiary care referral centres where selection bias may be important, the aim of this study was to examine underlying causes of recurrent pneumonia in children in a general hospital. We performed a retrospective chart review in a general hospital of 62 children with recurrent pneumonia over a 7.5 years period. In 19 patients (30.6%), no cause was identified, commonly because favourable natural history obviated the need for a full and invasive diagnostic work-up. Other underlying causes included recurrent aspiration in 16 patients (25.7%), lung disease (airway stenosis, bronchiectasis, middle lobe syndrome or tracheooesophageal fistula) in 10 patients (16.1%) and immune deficiency in 10 patients (16.1%). In contrast to previous studies, asthma was never diagnosed as an underlying cause, but diagnostic confusion between asthma (or recurrent upper respiratory tract infections) and recurrent pneumonia was common. The cause of recurrent pneumonia in children remains elusive in almost a third of patients, partly because the favourable natural history consistent with immune system maturation eliminates the need for further diagnostic procedures. Asthma is more likely a differential diagnostic consideration than an underlying cause of recurrent pneumonia in children. A standardised diagnostic guideline is needed to improve knowledge on causes of recurrent pneumonia in children. © 2013 The Authors. Journal of Paediatrics and Child Health © 2013 Paediatrics and Child Health Division (Royal Australasian College of Physicians).

  7. Immunomodulators to treat recurrent miscarriage

    NARCIS (Netherlands)

    Prins, Jelmer R.; Kieffer, Tom E.C.; Scherjon, Sicco A.

    2014-01-01

    Recurrent miscarriage is a reproductive disorder affecting many couples. Although several factors are associated with recurrent miscarriage, in more than 50% of the cases the cause is unknown. Maladaptation of the maternal immune system is associated with recurrent miscarriage and could explain part

  8. Radiation doses from radon and progeny in Irish houses

    International Nuclear Information System (INIS)

    McLaughlin, J.P.

    1985-08-01

    In the United Kingdom, the estimated average annual effective dose equivalent to members of the public from all sources is 2.4 mSv (240 mrem). 40% of this dose is contributed by exposure to radon, and it is not unreasonable to assume that the situation in Ireland is very similar. During 1982-84 a preliminary study of radon and penetrating radiation on 300 Irish houses showed seasonally averaged indoor radon concentrations in the range 3 Bq/m 3 of air to 700 bq/m 3 , with a median value of about 40 bq/m 3 . A national survey of indoor radon has now been undertaken; 3000 households, randomly selected from the electoral register are to be monitored and the result correlated with energy conservation practices. The final part of this document deals with the regulatory aspects of radon control and reviews the practices for reduction of indoor radon daughter doses presently in hand in Scandinavia. An appendix of radiation units and terms is also given

  9. Recurrent giant juvenile fibroadenoma

    Directory of Open Access Journals (Sweden)

    Kathryn S. King

    2017-11-01

    Full Text Available Breast masses in children, though rare, present a difficult clinical challenge as they can represent a wide variety of entities from benign fibroadenomas to phyllodes tumors. Rapidly growing or recurrent masses can be particularly concerning to patients, families and physicians alike. Clinical examination and conventional imaging modalities are not efficacious in distinguishing between different tumor types and surgical excision is often recommended for both final diagnosis and for treatment of large or rapidly growing masses. While surgical excision can result in significant long-term deformity of the breast there are some surgical techniques that can be used to limit deformity and/or aid in future reconstruction. Here we present a case of recurrent giant juvenile fibroadenoma with a review of the clinical presentation, diagnostic tools and treatment options.

  10. Recurrent Partial Words

    Directory of Open Access Journals (Sweden)

    Francine Blanchet-Sadri

    2011-08-01

    Full Text Available Partial words are sequences over a finite alphabet that may contain wildcard symbols, called holes, which match or are compatible with all letters; partial words without holes are said to be full words (or simply words. Given an infinite partial word w, the number of distinct full words over the alphabet that are compatible with factors of w of length n, called subwords of w, refers to a measure of complexity of infinite partial words so-called subword complexity. This measure is of particular interest because we can construct partial words with subword complexities not achievable by full words. In this paper, we consider the notion of recurrence over infinite partial words, that is, we study whether all of the finite subwords of a given infinite partial word appear infinitely often, and we establish connections between subword complexity and recurrence in this more general framework.

  11. Recurrent epileptic Wernicke aphasia.

    Science.gov (United States)

    Sahaya, Kinshuk; Dhand, Upinder K; Goyal, Munish K; Soni, Chetan R; Sahota, Pradeep K

    2010-04-15

    We report a patient with recurrent epileptic Wernicke aphasia who prior to this presentation, had been misdiagnosed as transient ischemic attacks for several years. This case report emphasizes the consideration of epileptic nature of aphasia when a clear alternate etiology is unavailable, even when EEG fails to show a clear ictal pattern. We also present a brief discussion of previously reported ictal aphasias. Copyright 2010 Elsevier B.V. All rights reserved.

  12. Training Recurrent Networks

    DEFF Research Database (Denmark)

    Pedersen, Morten With

    1997-01-01

    Training recurrent networks is generally believed to be a difficult task. Excessive training times and lack of convergence to an acceptable solution are frequently reported. In this paper we seek to explain the reason for this from a numerical point of view and show how to avoid problems when...... training. In particular we investigate ill-conditioning, the need for and effect of regularization and illustrate the superiority of second-order methods for training...

  13. Recurrent Tricuspid Insufficiency

    Science.gov (United States)

    Kara, Ibrahim; Koksal, Cengiz; Cakalagaoglu, Canturk; Sahin, Muslum; Yanartas, Mehmet; Ay, Yasin; Demir, Serdar

    2013-01-01

    This study compares the medium-term results of De Vega, modified De Vega, and ring annuloplasty techniques for the correction of tricuspid insufficiency and investigates the risk factors for recurrent grades 3 and 4 tricuspid insufficiency after repair. In our clinic, 93 patients with functional tricuspid insufficiency underwent surgical tricuspid repair from May 2007 through October 2010. The study was retrospective, and all the data pertaining to the patients were retrieved from hospital records. Functional capacity, recurrent tricuspid insufficiency, and risk factors aggravating the insufficiency were analyzed for each patient. In the medium term (25.4 ± 10.3 mo), the rates of grades 3 and 4 tricuspid insufficiency in the De Vega, modified De Vega, and ring annuloplasty groups were 31%, 23.1%, and 6.1%, respectively. Logistic regression analysis revealed that chronic obstructive pulmonary disease, left ventricular dysfunction (ejection fraction, tricuspid insufficiency. Medium-term survival was 90.6% for the De Vega group, 96.3% for the modified De Vega group, and 97.1% for the ring annuloplasty group. Ring annuloplasty provided the best relief from recurrent tricuspid insufficiency when compared with DeVega annuloplasty. Modified De Vega annuloplasty might be a suitable alternative to ring annuloplasty when rings are not available. PMID:23466680

  14. Multiplex Recurrence Networks

    Science.gov (United States)

    Eroglu, Deniz; Marwan, Norbert

    2017-04-01

    The complex nature of a variety of phenomena in physical, biological, or earth sciences is driven by a large number of degrees of freedom which are strongly interconnected. Although the evolution of such systems is described by multivariate time series (MTS), so far research mostly focuses on analyzing these components one by one. Recurrence based analyses are powerful methods to understand the underlying dynamics of a dynamical system and have been used for many successful applications including examples from earth science, economics, or chemical reactions. The backbone of these techniques is creating the phase space of the system. However, increasing the dimension of a system requires increasing the length of the time series in order get significant and reliable results. This requirement is one of the challenges in many disciplines, in particular in palaeoclimate, thus, it is not easy to create a phase space from measured MTS due to the limited number of available obervations (samples). To overcome this problem, we suggest to create recurrence networks from each component of the system and combine them into a multiplex network structure, the multiplex recurrence network (MRN). We test the MRN by using prototypical mathematical models and demonstrate its use by studying high-dimensional palaeoclimate dynamics derived from pollen data from the Bear Lake (Utah, US). By using the MRN, we can distinguish typical climate transition events, e.g., such between Marine Isotope Stages.

  15. Portable monitors for measuring radon and its progenies air by intergrated sampling method

    International Nuclear Information System (INIS)

    Zhang Huaiqin; Su Jingling; Yao Wanyuan; Liu Jinhua

    1989-01-01

    Two kinds of portable monitors have been developed, which can be used to measure the concentration of radon or potential energy concentration of radon or potential energy concentration of radon progenies in air. The thermoluminescent material CaSO 4 (Tm) is used as a detecting element for both of them. The lowest detectable limit of the passive radon monitor is about 1.5 Bq/m 3 for radon in air, as the exposure time being one week. Its main advantages are high reliability and convenient manipulation. The working level monitor for radon progenies in air consists of a mini membrane pump and an integrating probe. The lowest detectable limit is about 6.2 x 10 -9 J/m 3 , as the sampling time being 6 hours. It weights only about 0.35 kg

  16. Experimental verification of the attachment theory of radon progeny onto ambient aerosols

    Energy Technology Data Exchange (ETDEWEB)

    Tokonami, Shinji

    2000-01-01

    The attachment theory of radon progeny onto ambient aerosols was experimentally verified with a cascade impactor and a graded screen array at the EML environmental chamber. Monodisperse aerosols in the size range of 70 to 500 nm were generated with Carnauba wax by means of the evaporation-condensation method. The temperature and the relative humidity in the chamber were set at 20 C and 20%, respectively, throughout the entire experiment. When the aerosols were being injected into the chamber, both the number size distribution and the activity-weighted size distribution of attached radon progeny were stable. The activity-weighted size distribution was compared with the attachment rate distribution obtained by measuring the number size distribution with the SMPS and multiplying the size-dependent attachment coefficient. There was a relatively good agreement between the two distributions.

  17. Measurement of unattached aerosols of 222 Rn progeny by means of an electrostatic deposition method

    International Nuclear Information System (INIS)

    Canoba, Analia C.; Lopez, Fabio O.

    2001-01-01

    A method for the measurement of unattached radon progeny based on its electrostatic deposition onto wire screens, using only one pump, has been implemented and calibrated. The importance of being able of making use of this method is related with the special radiological significance that has the unattached fraction of the short-lived radon progeny. Because of this, the assesment of exposure could be directly related to dose with far greater accuracy than before.The advantages of this method are its simplicity, even with the tools needed for the sample collection, as well as the measurement instruments used. Also, the suitability of this method is enhanced by the fact that it can effectively be used with a simple measuring procedure such as the Kusnetz method. (author)

  18. Inherited sterility in progeny of irradiated male cotton leafworm, spodoptera littoralis (boisd)

    International Nuclear Information System (INIS)

    Sallam, H.A.

    1991-01-01

    Full grown male pupae of spodoptera littoralis were exposed to sub sterilizing doses of 7.5, 10, 12.5 or 15 krad of gamma radiation and mated with unirradiated females. In another trial, male pupae irradiated with 10 krad were crossed with unirradiated females, and their progeny were out crossed or inbred. In all cases, the effects of these treatments on some biological aspects in the resulting progeny for 3 generations were studied. Larval and pupal mortality were 21 to 53% and 5 to 30% higher than the normal among F 1 and F 2 , respectively. THE average developmental time from egg hatch to adult emergence was not affected and so, also sex ratio which seemed about normal.2 tab

  19. Inherited sterility in progeny of irradiated male cotton leafworm, spodoptera littoralis (boisd)

    Energy Technology Data Exchange (ETDEWEB)

    Sallam, H A

    1991-01-01

    Full grown male pupae of spodoptera littoralis were exposed to sub sterilizing doses of 7.5, 10, 12.5 or 15 krad of gamma radiation and mated with unirradiated females. In another trial, male pupae irradiated with 10 krad were crossed with unirradiated females, and their progeny were out crossed or inbred. In all cases, the effects of these treatments on some biological aspects in the resulting progeny for 3 generations were studied. Larval and pupal mortality were 21 to 53% and 5 to 30% higher than the normal among F[sub 1] and F[sub 2], respectively. THE average developmental time from egg hatch to adult emergence was not affected and so, also sex ratio which seemed about normal.2 tab.

  20. Studies of Radon and Radon Progeny in Air Conditioned Rooms in Hospitals

    International Nuclear Information System (INIS)

    Marley, F.; Denman, A.R.; Phillips, P.S.

    1998-01-01

    A series of continuous real-time radon and radon progeny measurements together with passive etched track detector measurements were performed in hospital premises during 1996. In one small room, detailed measurements over several weeks showed that both the radon concentration and the Equilibrium Factor depended on the intermittent operation of a filtered positive pressure displacement air-conditioning system, which was designed to conform to operating theatre standards. The average radon level measured while the air-conditioning was off was almost four times higher than that recorded whilst it was on. The progeny level was over five times higher than that whilst it was on. Thus, the Equilibrium Factor (F), was significantly lower when the air-conditioning was on. Measurements in similar rooms in two hospitals, confirmed that the reduction in radon level was a general finding. Thus staff working in such environments receive significantly lower radiation dose from radon than staff working in nearby normally ventilated rooms. (author)

  1. Environmental Concentration of Radon and Radon Progeny in a Nuclear Facility in a Decommissioning Stage

    International Nuclear Information System (INIS)

    Ramirez, M. P.; Correa, E.; Sancho, C.

    1999-01-01

    According to the new European Directive 96/29/EURATOM the radiological risk due to natural radionuclides must be consider and the pertinent periodic control must be realized. During the works performed at CIEMAT an estimation of the effective average doses due to Radon inhalation in work places of the installation have been performed. Radon and Radon progeny concentration has been measured in continuous joint whit the meteorological conditions as temperature, pressure and relative humidity. Two different equipment has been used: Alpha-guard whit ionization chamber detector and Eda-wlm-300 whit a semiconductor detector. A passive Radon detector, E-perm has been simultaneously used in the monitoring system. The results obtained during the measuring of Radon and Radon progeny concentrations indoors and estimation of doses have been analyzed and are presented in the paper. (Author) 11 refs

  2. Ethanol Consumption by Wistar Rat Dams Affects Selenium Bioavailability and Antioxidant Balance in Their Progeny

    Directory of Open Access Journals (Sweden)

    Olimpia Carreras

    2009-07-01

    Full Text Available Ethanol consumption affects maternal nutrition, the mothers’ antioxidant balance and the future health of their progeny. Selenium (Se is a trace element cofactor of the enzyme glutathione peroxidase (GPx. We will study the effect of ethanol on Se bioavailability in dams and in their progeny. We have used three experimental groups of dams: control, chronic ethanol and pair-fed; and three groups of pups. Se levels were measured by graphite-furnace atomic absorption spectrometry. Serum and hepatic GPx activity was determined by spectrometry. We have concluded that ethanol decreased Se retention in dams, affecting their tissue Se deposits and those of their offspring, while also compromising their progeny’s weight and oxidation balance. These effects of ethanol are caused by a reduction in Se intake and a direct alcohol-generated oxidation action.

  3. Vesicular transport of progeny parvovirus particles through ER and Golgi regulates maturation and cytolysis.

    Science.gov (United States)

    Bär, Séverine; Rommelaere, Jean; Nüesch, Jürg P F

    2013-09-01

    Progeny particles of non-enveloped lytic parvoviruses were previously shown to be actively transported to the cell periphery through vesicles in a gelsolin-dependent manner. This process involves rearrangement and destruction of actin filaments, while microtubules become protected throughout the infection. Here the focus is on the intracellular egress pathway, as well as its impact on the properties and release of progeny virions. By colocalization with cellular marker proteins and specific modulation of the pathways through over-expression of variant effector genes transduced by recombinant adeno-associated virus vectors, we show that progeny PV particles become engulfed into COPII-vesicles in the endoplasmic reticulum (ER) and are transported through the Golgi to the plasma membrane. Besides known factors like sar1, sec24, rab1, the ERM family proteins, radixin and moesin play (an) essential role(s) in the formation/loading and targeting of virus-containing COPII-vesicles. These proteins also contribute to the transport through ER and Golgi of the well described analogue of cellular proteins, the secreted Gaussia luciferase in absence of virus infection. It is therefore likely that radixin and moesin also serve for a more general function in cellular exocytosis. Finally, parvovirus egress via ER and Golgi appears to be necessary for virions to gain full infectivity through post-assembly modifications (e.g. phosphorylation). While not being absolutely required for cytolysis and progeny virus release, vesicular transport of parvoviruses through ER and Golgi significantly accelerates these processes pointing to a regulatory role of this transport pathway.

  4. Evaluation of recurrent disease in the re-staging of colorectal cancer by 18F-FDG PET/CT: Use of CEA and CA 19-9 in patient selection.

    Science.gov (United States)

    Chiaravalloti, Agostino; Fiorentini, Alessandro; Palombo, Erika; Rinino, Davide; Lacanfora, Annamaria; Danieli, Roberta; Di Russo, Carmen; Di Biagio, Daniele; Squillaci, Ettore; Schillaci, Orazio

    2016-11-01

    The aim of the present retrospective study was to evaluate the sensitivity and specificity of fluorodeoxyglucose ( 18 F-FDG) positron emission tomography/computed tomography (PET/CT) in assessing the recurrence of colorectal cancer (CRC) with regard to carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA 19-9). 18 F-FDG PET/CT was performed in 100 patients for the re-staging of CRC. Therapy was discontinued prior to the examination. The mean (± standard deviation) CEA value (measured ~30 days prior to PET/CT examination) was 23.71 (±107) ng/ml, whereas the CA 19-9 value was 72 (±190.3) U/ml. Differences in CEA and CA 19-9 values in patients with scans that were positive or negative for recurrence were analyzed by means of a receiver operating characteristic (ROC) curve. ROC curves were used for the calculation of the sensitivity and specificity of 18 F-FDG PET/CT for the CEA and CA 19-9 levels. The results of the 18 F-FDG PET/CT were found to be associated with the CEA level (P=0.001), but not with the CA 19-9 level (P=0.43). PET/CT was positive for recurrence in 60 patients (60.0%), whose mean CEA and CA 19-9 values were 33.07±136.7 ng/ml and 75.24±192.3 U/ml, respectively. PET/CT was negative for recurrence in 40 patients (40.0%), whose mean CEA and CA 19-9 values were 10.15±30 ng/ml and 67.76±190 U/ml, respectively. On the basis of ROC curve analysis, the best compromise between sensitivity and specificity was achieved for CEA levels of 3.5 ng/ml [sensitivity, 80%; 95% confidence interval (CI), 67-89%; and specificity, 60%; 95% CI, 45-78%]. The study concluded that the detection of recurrence by 18 F-FDG PET/CT in patients treated for CRC is associated with CEA, but not CA 19-9 serum levels. Moreover, 18 F-FDG PET/CT should be recommended in patients with suspected CRC recurrence even when they present with CEA levels below the normal cut-off.

  5. Evaluation of recurrent disease in the re-staging of colorectal cancer by 18F-FDG PET/CT: Use of CEA and CA 19–9 in patient selection

    Science.gov (United States)

    Chiaravalloti, Agostino; Fiorentini, Alessandro; Palombo, Erika; Rinino, Davide; Lacanfora, Annamaria; Danieli, Roberta; Di Russo, Carmen; Di Biagio, Daniele; Squillaci, Ettore; Schillaci, Orazio

    2016-01-01

    The aim of the present retrospective study was to evaluate the sensitivity and specificity of fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) in assessing the recurrence of colorectal cancer (CRC) with regard to carcinoembryonic antigen (CEA) and carbohydrate antigen 19–9 (CA 19–9). 18F-FDG PET/CT was performed in 100 patients for the re-staging of CRC. Therapy was discontinued prior to the examination. The mean (± standard deviation) CEA value (measured ~30 days prior to PET/CT examination) was 23.71 (±107) ng/ml, whereas the CA 19–9 value was 72 (±190.3) U/ml. Differences in CEA and CA 19–9 values in patients with scans that were positive or negative for recurrence were analyzed by means of a receiver operating characteristic (ROC) curve. ROC curves were used for the calculation of the sensitivity and specificity of 18F-FDG PET/CT for the CEA and CA 19–9 levels. The results of the 18F-FDG PET/CT were found to be associated with the CEA level (P=0.001), but not with the CA 19–9 level (P=0.43). PET/CT was positive for recurrence in 60 patients (60.0%), whose mean CEA and CA 19–9 values were 33.07±136.7 ng/ml and 75.24±192.3 U/ml, respectively. PET/CT was negative for recurrence in 40 patients (40.0%), whose mean CEA and CA 19–9 values were 10.15±30 ng/ml and 67.76±190 U/ml, respectively. On the basis of ROC curve analysis, the best compromise between sensitivity and specificity was achieved for CEA levels of 3.5 ng/ml [sensitivity, 80%; 95% confidence interval (CI), 67–89%; and specificity, 60%; 95% CI, 45–78%]. The study concluded that the detection of recurrence by 18F-FDG PET/CT in patients treated for CRC is associated with CEA, but not CA 19–9 serum levels. Moreover, 18F-FDG PET/CT should be recommended in patients with suspected CRC recurrence even when they present with CEA levels below the normal cut-off. PMID:27895793

  6. Estimation of radon progeny equilibrium factors and their uncertainty bounds using solid state nuclear track detectors

    International Nuclear Information System (INIS)

    Eappen, K.P.; Mayya, Y.S.; Patnaik, R.L.; Kushwaha, H.S.

    2006-01-01

    For the assessment of inhalation doses due to radon and its progeny to uranium mine workers, it is necessary to have information on the time integrated gas concentrations and equilibrium factors. Passive single cup dosimeters using solid state nuclear track detectors (SSNTD) are best suited for this purpose. These generally contain two SSNTDs, one placed inside the cup to measure only the radon gas concentration and other outside the cup for recording tracks due to both radon gas and the progeny species. However, since one obtains only two numbers by this method whereas information on four quantities is required for an unambiguous estimation of dose, there is a need for developing an optimal methodology for extracting information on the equilibrium factors. Several techniques proposed earlier have essentially been based on deterministic approaches, which do not fully take into account all the possible uncertainties in the environmental parameters. Keeping this in view, a simple 'mean of bounds' methodology is proposed to extract equilibrium factors based on their absolute bounds and the associated uncertainties as obtained from general arguments of radon progeny disequilibrium. This may be considered as reasonable estimates of the equilibrium factors in the absence of a knowledge of fluctuation in the environmental variables. The results are compared with those from direct measurements both in the laboratory and in real field situations. In view of the good agreement found between these, it is proposed that the simple mean of bounds estimate may be useful for practical applications in inhalation dosimetry of mine workers

  7. Paternal cocaine taking elicits epigenetic remodeling and memory deficits in male progeny.

    Science.gov (United States)

    Wimmer, M E; Briand, L A; Fant, B; Guercio, L A; Arreola, A C; Schmidt, H D; Sidoli, S; Han, Y; Garcia, B A; Pierce, R C

    2017-11-01

    Paternal environmental perturbations including exposure to drugs of abuse can produce profound effects on the physiology and behavior of offspring via epigenetic modifications. Here we show that adult drug-naive male offspring of cocaine-exposed sires have memory formation deficits and associated reductions in NMDA receptor-mediated hippocampal synaptic plasticity. Reduced levels of the endogenous NMDA receptor co-agonist d-serine were accompanied by increased expression of the d-serine degrading enzyme d-amino acid oxidase (Dao1) in the hippocampus of cocaine-sired male progeny. Increased Dao1 transcription was associated with enrichment of permissive epigenetic marks on histone proteins in the hippocampus of male cocaine-sired progeny, some of which were enhanced near the Dao1 locus. Finally, hippocampal administration of d-serine reversed both the memory formation and synaptic plasticity deficits. Collectively, these results demonstrate that paternal cocaine exposure produces epigenetic remodeling in the hippocampus leading to NMDA receptor-dependent memory formation and synaptic plasticity impairments only in male progeny, which has significant implications for the male descendants of chronic cocaine users.

  8. The predatory mite Phytoseiulus persimilis adjusts patch-leaving to own and progeny prey needs.

    Science.gov (United States)

    Vanas, V; Enigl, M; Walzer, A; Schausberger, P

    2006-01-01

    Integration of optimal foraging and optimal oviposition theories suggests that predator females should adjust patch leaving to own and progeny prey needs to maximize current and future reproductive success. We tested this hypothesis in the predatory mite Phytoseiulus persimilis and its patchily distributed prey, the two-spotted spider mite Tetranychus urticae. In three separate experiments we assessed (1) the minimum number of prey needed to complete juvenile development, (2) the minimum number of prey needed to produce an egg, and (3) the ratio between eggs laid and spider mites left when a gravid P. persimilis female leaves a patch. Experiments (1) and (2) were the pre-requirements to assess the fitness costs associated with staying or leaving a prey patch. Immature P. persimilis needed at least 7 and on average 14+/-3.6 (SD) T. urticae eggs to reach adulthood. Gravid females needed at least 5 and on average 8.5+/-3.1 (SD) T. urticae eggs to produce an egg. Most females left the initial patch before spider mite extinction, leaving prey for progeny to develop to adulthood. Females placed in a low density patch left 5.6+/-6.1 (SD) eggs per egg laid, whereas those placed in a high density patch left 15.8+/-13.7 (SD) eggs per egg laid. The three experiments in concert suggest that gravid P. persimilis females are able to balance the trade off between optimal foraging and optimal oviposition and adjust patch-leaving to own and progeny prey needs.

  9. Generation of viable progeny from dead brooders of endangered catfish Clarias magur (Hamilton, 1822

    Directory of Open Access Journals (Sweden)

    Sullip Kumar Majhi

    2017-10-01

    Full Text Available The obligatory air-breathing catfish Clarias magur is a prime candidate for aquaculture owing to its unique taste, high growth rate, and hardy nature. However, recently the IUCN has listed the species under the endangered category because the population has critically declined in the wild. The sexually mature C. magur brooders are often collected from their natural habitats for seed production in captivity. In many cases, the brooder dies due to handling injuries or confinement stress. In this study, we demonstrated that viable progeny could be generated from freshly dead sexually mature C. magur. Three hours after death, the gonads were excised, macroscopically examined and gamete viability was evaluated. Artificial fertilization was performed by mixing the sperm suspension with the eggs. Water was added after 1 min of mixing to activate the fertilization process. We observed 85%-93% fertilization success from gametes derived from dead donors as opposed to 90%-95% from those derived from live control donors. The embryos showed normal development and resulted in the generation of 88%-92% viable progeny, which was similar to the progeny derived from control donors (92%-93%. The results obtained in this study will have profound implications in enhancing the seed production of endangered C. magur and could potentially be applied to other key commercially or endangered fish species. Keywords: Biological sciences, Developmental biology, Zoology

  10. Indoor radon and its progeny levels in new type houses in rural area of Hubei

    International Nuclear Information System (INIS)

    He Quan; Xiong Zhaoxing; He Zuan; Zheng Youqing

    1993-01-01

    Using Cluster Sampling method, indoor radon of 54 rooms and radon progeny potential alpha-energy concentrations of 200 rooms were measured in the new type brick-concrete 2-storey flats and old type brick-wood single-storey residences in the rural area. Instant and cumulative samplings and measurements were made. The average per capita residential area of the surveyed houses was 28.1 m 2 , clear height 3.6 m. The geometric means of indoor radon concentration were 18.22 Bq.m -3 and 15.93 Bq.m -3 for storied and single-storey buildings, respectively; radon progeny potential alpha-energy concentrations were 2.62 mWL and 2.54 mWL, correspondingly. In storied buildings, the arithmetic mean of indoor cumulative radon concentration was 25.56 Bq.m -3 in summer, and 37.94 Bq.m -3 in winter. The annual effective dose equivalent of radon progeny inhaled indoors and outdoors was 0.80 mSv. (orig.). (6 refs., 1 fig., 5 tabs.)

  11. Exposures to 222Rn and its progeny derived from implanted 210Po activity

    International Nuclear Information System (INIS)

    Nikezic, D.; Yu, K.N.

    2006-01-01

    The Jacobi room model was applied to study the relative contributions from the unattached and attached fractions to the implanted activity of 210 Po. It was found that under normal conditions, about 85% of the implantation was due to the unattached fraction. Sensitivity analysis was performed to identify the most important factors that influence the deposition and implantation of radon progeny. The main factors affecting the incorporation of 210 Po are the attachment rate, deposition rate of unattached progeny and the surface to volume ratio of the room. The calibration curves, which related the 210 Po activity per unit surface area to the concentrations of 222 Rn and of the radon progeny, were determined as functions of exposure times. The implanted activity is found to distribute close to a lognormal distribution. For an exposure of 20 years, the distribution has a geometric standard deviation of 2.2 and a geometric mean of 0.023Bq/m 2 /(Bq/m 3 ). The last value is considered as the calibration coefficient of the glass response in terms of the implanted 210 Po activity per unit surface area per unit concentration of 222 Rn for an exposure period of 20 years

  12. Assessment of nanoparticle surface area by measuring unattached fraction of radon progeny

    Energy Technology Data Exchange (ETDEWEB)

    Ruzer, Lev S. [Ernest Orlando Lawrence Berkeley National Laboratory, Indoor Environment Department (United States)], E-mail: LSRuzer@lbl.gov

    2008-05-15

    A number of studies on the exposure of nanometer aerosols have indicated that health effects associated with low-solubility inhaled particles in the range of 1-100 nm may be more appropriately associated with particulate surface area than mass concentration. Such data on correlation between number, surface area and mass concentration are needed for exposure investigations, but the means for measuring aerosol surface area are not readily available. In this paper we propose a method for particle surface area assessment based on a new approach, deposition of the 'unattached fraction of radon progeny' onto nanometer aerosols.The proposed approach represents a synthesis of:(1) Derived direct analytical correlation between the 'unattached fraction' of radon progeny and surface area particle concentration in the range of 1-100 nm particle diameter;(2) Experimental data on correlation between the unattached fraction of radon progeny and particle surface area for particles with diameter in the range of 44 nm-2.1 {mu}m.

  13. Study on the influence of CR-39 detector size on radon progeny detection in indoor environments

    Energy Technology Data Exchange (ETDEWEB)

    Pereira, L. A.; Hadler, J. C.; Lixandrão F, A. L.; Guedes, S.; Takizawa, R. H. [Instituto de Física Gleb Wataghin, Universidade Estadual de Campinas, UNICAMP, 13083-970 Campinas, SP (Brazil)

    2014-11-11

    It is well known that radon daughters up to {sup 214}Po are the real contaminants to be considered in case of indoor radon contamination. Assemblies consisting of 6 circular bare sheets of CR-39, a nuclear track detector, with radius varying from 0.15 to 1.2 cm were exposed far from any material surface for periods of approximately 6 months in 13 different indoor rooms (7 workplaces and 6 dwellings), where ventilation was moderate or poor. It was observed that track density was as greater as smaller was the detector radius. Track density data were fitted using an equation deduced based on the assumption that the behavior of radon and its progeny in the air was described by Fick's Law, i.e., when the main mechanism of transport of radon progeny in the air is diffusion. As many people spend great part of their time in closed or poorly ventilated environments, the confirmation they present equilibrium between radon and its progeny is an interesting start for dosimetric calculations concerning this contamination.

  14. Evaluasi Resistensi Progeni Anggrek Phalaenopsis terhadap Penyakit Busuk Lunak (Pseudomonas viridiflava

    Directory of Open Access Journals (Sweden)

    Hanudin Hanudin

    2018-01-01

    Full Text Available A bacterial soft rot disease caused by P. viridiflava was one of problems in orchid nursery, especially Phalaenopsis.  An evaluation on progenies derived from three crossing combinations were conducted to find out the symptom characteristic, development of infections of the disease and resistance response of the progenies against artificial infection of P. viridiflava. The research was conducted under a standard glass house conditions for Phalaenopsis involving 31 individuals from 3 progeny populations, namely P.157, E.2153 and E.2189. The results showed that symptoms were characterized by the lesion of the leaf tissues. On most accessions, the lesion enlarged and foul odor was detected as an indication of the successful establishment of bacterial infection. Based on the disease severity, three accessions (P.157-12, P.157-45, and P.157-71 had the lowest infections and were classified into resistant genotypes. One accession, i.e. P.157-32 was classified as susceptible and the rest 27 accessions were grouped into very susceptible class.

  15. Progeny of male rats treated with methadone: physiological and behavioural effects.

    Science.gov (United States)

    Joffe, J M; Peruzović, M; Milković, K

    1990-04-01

    Male rats were injected with methadone HCl (METH) at 5 mg/kg s.c. for 4 days prior to mating with drug-free females. Offspring resulting from these matings were compared with offspring of drug-free males. The progeny of METH-treated males gained less weight after weaning and had lighter thymuses as adults (but not in infancy). Gonadal weights did not differ in infancy or adulthood, and adrenal weights were heavier in female offspring in adulthood. In adulthood METH offspring were significantly different from controls on all behavioural tests used (open field activity, activity cage activity, passive avoidance latencies, shuttle box avoidances, and rotarod latencies), with the differences frequently affected by test order, days of testing, or sex of offspring. The effects in progeny of METH-treated males in the absence of differences in litter size or neonatal mortality indicate that paternal drug ingestion prior to mating can produce physiological and behavioural changes in progeny that are not dependent on detectable effects on early viability or growth.

  16. Characteristics of radon and its progeny concentrations in air-conditioned office buildings in Tokyo

    International Nuclear Information System (INIS)

    Tokonami, S.; Furukawa, M.; Shicchi, Y.; Sanada, T.; Yamada, Y.

    2003-01-01

    A series of measurements were carried out to understand the characteristics of radon and its progeny in air-conditioned office buildings. Long-term measurements of radon were made with etched track detectors. Continuous measurements of radon and its progeny concentrations were also conducted in some buildings to study their temporal variations. The results show that radon and its progeny concentrations routinely varied along with working activities. They are generally low while people are working, due to air conditioning, whereas they rise steadily after the air conditioning stops. When considering action levels not only in homes but also workplaces, attention should be paid to annual doses from the viewpoint of radiation protection. The annual dose is generally estimated with a long-term measurement of radon concentration using a passive device such as an etched track detector. Since its reading corresponds to a long-term average concentration regardless of working hours, the annual dose will be overestimated. When comparing a real dose after considering the working hours, they differ by a factor of more than 2. (author)

  17. Predictors of recurrence in pheochromocytoma.

    Science.gov (United States)

    Press, Danielle; Akyuz, Muhammet; Dural, Cem; Aliyev, Shamil; Monteiro, Rosebel; Mino, Jeff; Mitchell, Jamie; Hamrahian, Amir; Siperstein, Allan; Berber, Eren

    2014-12-01

    The recurrence rate of pheochromocytoma after adrenalectomy is 6.5-16.5%. This study aims to identify predictors of recurrence and optimal biochemical testing and imaging for detecting the recurrence of pheochromocytoma. In this retrospective study we reviewed all patients who underwent adrenalectomy for pheochromocytoma during a 14-year period at a single institution. One hundred thirty-five patients had adrenalectomy for pheochromocytoma. Eight patients (6%) developed recurrent disease. The median time from initial operation to diagnosis of recurrence was 35 months. On multivariate analysis, tumor size >5 cm was an independent predictor of recurrence. One patient with recurrence died, 4 had stable disease, 2 had progression of disease, and 1 was cured. Recurrence was diagnosed by increases in plasma and/or urinary metanephrines and positive imaging in 6 patients (75%), and by positive imaging and normal biochemical levels in 2 patients (25%). Patients with large tumors (>5 cm) should be followed vigilantly for recurrence. Because 25% of patients with recurrence had normal biochemical levels, we recommend routine imaging and testing of plasma or urinary metanephrines for prompt diagnosis of recurrence. Copyright © 2014 Elsevier Inc. All rights reserved.

  18. Utilisation of an Air-conditioning System to Control the Levels of Radon and Radon Progeny in a Workplace Environment

    International Nuclear Information System (INIS)

    Marley, F.

    2000-01-01

    From long-term real-time radon and radon progeny measurements taken in a relatively large retail store, cyclical patterns were evident, which were found to relate to the overriding influence of the timed air-conditioning system. Concentration of radon, radon progeny and the variability of F factor were found to depend significantly on the intermittent operation of this ventilation-air-conditioning system. After pressure equalisation remedial measures proved ineffective, the air-movement system was utilised to reduce the levels of radon and radon progeny to well within established norms applicable during working hours. It is demonstrated that the average levels for radon and radon progeny are reduced in absolute terms. This amounted to less than 12% of the general level, during designated work periods. Where air movement systems are already installed, as well as other circumstances, their regulation provides an economical solution to meeting legal and other standards for radon in the workplace. (author)

  19. Particle size distribution of the radon progeny and ambient aerosols in the Underground Tourist Route "Liczyrzepa" Mine in Kowary Adit

    Science.gov (United States)

    Wołoszczuk, Katarzyna; Skubacz, Krystian

    2018-01-01

    Central Laboratory for Radiological Protection, in cooperation with Central Mining Institute performed measurements of radon concentration in air, potential alpha energy concentration (PAEC), particle size distribution of the radon progeny and ambient aerosols in the Underground Tourist-Educational Route "Liczyrzepa" Mine in Kowary Adit. A research study was developed to investigate the appropriate dose conversion factors for short-lived radon progeny. The particle size distribution of radon progeny was determined using Radon Progeny Particle Size Spectrometer (RPPSS). The device allows to receive the distribution of PAEC in the particle size range from 0.6 nm to 2494 nm, based on their activity measured on 8 stages composed of impaction plates or diffusion screens. The measurements of the ambient airborne particle size distribution were performed in the range from a few nanometres to about 20 micrometres using Aerodynamic Particle Sizer (APS) spectrometer and the Scanning Mobility Particle Sizer Spectrometer (SMPS).

  20. Epstein-Barr Virus BKRF4 Gene Product Is Required for Efficient Progeny Production.

    Science.gov (United States)

    Masud, H M Abdullah Al; Watanabe, Takahiro; Yoshida, Masahiro; Sato, Yoshitaka; Goshima, Fumi; Kimura, Hiroshi; Murata, Takayuki

    2017-12-01

    Epstein-Barr virus (EBV), a member of human gammaherpesvirus, infects mainly B cells. EBV has two alternative life cycles, latent and lytic, and is reactivated occasionally from the latent stage to the lytic cycle. To combat EBV-associated disorders, understanding the molecular mechanisms of the EBV lytic replication cycle is also important. Here, we focused on an EBV lytic gene, BKRF4. Using our anti-BKRF4 antibody, we revealed that the BKRF4 gene product is expressed during the lytic cycle with late kinetics. To characterize the role of BKRF4, we constructed BKRF4-knockout mutants using the bacterial artificial chromosome (BAC) and CRISPR/Cas9 systems. Although disruption of the BKRF4 gene had almost no effect on viral protein expression and DNA synthesis, it significantly decreased progeny virion levels in HEK293 and Akata cells. Furthermore, we show that BKRF4 is involved not only in production of progeny virions but also in increasing the infectivity of the virus particles. Immunoprecipitation assays revealed that BKRF4 interacted with a virion protein, BGLF2. We showed that the C-terminal region of BKRF4 was critical for this interaction and for efficient progeny production. Immunofluorescence analysis revealed that BKRF4 partially colocalized with BGLF2 in the nucleus and perinuclear region. Finally, we showed that BKRF4 is a phosphorylated, possible tegument protein and that the EBV protein kinase BGLF4 may be important for this phosphorylation. Taken together, our data suggest that BKRF4 is involved in the production of infectious virions. IMPORTANCE Although the latent genes of EBV have been studied extensively, the lytic genes are less well characterized. This study focused on one such lytic gene, BKRF4, which is conserved only among gammaherpesviruses (ORF45 of Kaposi's sarcoma-associated herpesvirus or murine herpesvirus 68). After preparing the BKRF4 knockout virus using B95-8 EBV-BAC, we demonstrated that the BKRF4 gene was involved in infectious

  1. Eco-logo-genetical characteristic of seed progeny of the Taraxacum officinale S.L. from the zone of east-ural radioactive trace

    International Nuclear Information System (INIS)

    Pozolotina, V.; Ulyanova, E.

    2004-01-01

    Levels of soil contamination with 90 Sr and 137 Cs radionuclides within the zone of Eastern-Ural radioactive trace, at the plots differently distant from the place of Kyshtym accident of 1957, exceed values of the global level 4-40 times. It was shown that the same coeno-population from EURT in the different years revealed the whole variety of previously described low-level irradiation effects. They are: stimulating one (vitality indexes in seed progeny exceed significantly those registered in the background samples); the depressing one, marked for high mortality level; and an indifferent effect showing neither significant differences from the background plants. Variation scope exceeding the normal one in regard to plants growth and development rates, as well as high frequencies of chromosome and morphological aberrations indicate to the plant genome non-stability caused by chronic low-level irradiation loads. Seed progeny also demonstrated the similar ambiguous response to additional irradiation, which is confirmed by allozyme analysis results. Standard electrophoretic methods are applicable to the dandelion studies. Some enzyme systems (Got, Dia) seem to be more suitable for seedlings, whereas the others provided satisfactory results being used for the seed material. In plant coeno-populations situated in radionuclides-polluted zone, genomic recombination processes show higher intensity. High enzymatic variability provides the material for natural selection and increase the adaptive potential of coeno-populations. (author)

  2. Variability of silver fir (Abies alba Mill. progeny from the Tisovik Reserve expressed in needle traits and chloroplast microsatellite DNA

    Directory of Open Access Journals (Sweden)

    Pawlaczyk Ewa M.

    2017-01-01

    Full Text Available Progeny from nineteen family lines of silver fir (Abies alba Mill. from the Tisovik Reserve growing in an experimental plot were analyzed based on 4 chloroplast microsatellite DNA loci and 12 morphological and anatomical needle traits. The Tisovik Reserve is located in Białowieża Primeval Forest, 120 km north of the natural range limit of this species, and embraces a small and isolated natural population of silver fir. The aim of this study was to determine genetic variation within and between progeny lines. Analysis of phenotypic variation showed that the traits which differed most among individuals were the needle width and the distance from resin canals to vascular bundle. Those traits, which differed most between the progeny lines, were the number of endodermic cells around the vascular bund and the weight of hypodermic cells. In Tisovik progeny, we detected 107 different haplotypes. In progeny lines, we detected more haplotypes than in maternal trees, and most haplotypes did not exist in maternal trees. This may be the result of pollen influx from other silver fir stands. Progeny from Tisovik showed a higher level of variability in comparison with maternal trees.

  3. Measurement of radon and thoron progeny size distributions and dose assessments at the mineral treatment industry in Thailand

    International Nuclear Information System (INIS)

    Chutima Kranrod; Supitcha Chanyotha; Nares Chankow

    2013-01-01

    A new portable type cascade impactor has been developed to determine the activity size distribution of radon and thoron progeny in a natural environment more efficiently. The modified impactor consists of 4 stages with a back up filter stage for the collection of aerosol samples. The aerosol cut points in the impactor are set for 10, 2.5, 1 and 0.5 μm at a flow rate of 4 L min -1 . Five CR-39 chips were used as alpha detectors for each stage. In order to separate α particles emitted from radon and thoron progeny, CR-39 detectors are covered with aluminum-vaporized Mylar films. The thickness of each film is adjusted to allow α particles emitted from radon and thoron progeny to reach the CR-39 detectors. The technique has been successfully tested in field studies, particularly inside a mineral treatment industry in Thailand to estimate doses in the working environment. The dose calculations by lung dose evaluation program showed that activity median aerodynamic diameters played a significant role in determining the particle size distributions of the attached radon and thoron progeny. The dose conversion factor determined from short term measurements due to exposure from the inhalation of thoron and its progeny was found to be 4 times higher than comparable values for radon and its progeny. The effective dose for workers exposed to radon is about 4-6 times higher than thoron. (author)

  4. Intercomparison of active, passive and continuous instruments for radon and radon progeny measurements in the EML chamber and test facility

    International Nuclear Information System (INIS)

    George, A.C.; Knutson, E.O.; Tu, K.W.; Fisenne, I.M.

    1995-12-01

    The results from the May 1995 Intercomparison of Active, Passive and Continuous Instruments for Radon and Radon Progeny Measurement conducted in the EML radon exposure and test facility are presented. Represented were 13 participants that measure radon with open faced and diffusion barrier activated carbon collectors, 10 with nuclear alpha track detectors, 9 with short-term and long-term electret/ionization chambers, and 13 with active and passive commercial electronic continuous monitors. For radon progeny, there were four participants that came in person to take part in the grab sampling methodology for measuring individual radon progeny and the potential alpha energy concentration (PAEC). There were 11 participants with continuous and integrating commercial electronic instruments that are used for measuring the PAEC. The results indicate that all the tested instruments that measure radon fulfill their intended purpose. All instruments and methods used for grab sampling for radon progeny did very well. However, most of the continuous and integrating electronic instruments used for measuring the PAEC or working level appear to underestimate the potential risk from radon progeny when the concentration of particles onto which the radon progeny are attached is -3

  5. Recurrent cerebral thrombosis

    International Nuclear Information System (INIS)

    Iwamoto, Toshihiko; Abe, Shin-e; Kubo, Hideki; Hanyu, Haruo; Takasaki, Masaru

    1992-01-01

    Neuroradiological techniques were used to elucidate pathophysiology of recurrent cerebral thrombosis. Twenty-two patients with cerebral thrombosis who suffered a second attack under stable conditions more than 22 days after the initial stroke were studied. Hypertension, diabetes mellitus, and hypercholesterolemia were also seen in 20, 8, and 12 patients, respectively. The patients were divided into three groups according to their symptoms: (I) symptoms differed between the first and second strokes (n=12); (II) initial symptoms were suddenly deteriorated (n=6); and (III) symptoms occurring in groups I and II were seen (n=4). In group I, contralateral hemiparesis or suprabulbar palsy was often associated with the initial hemiparesis. The time of recurrent stroke varied from 4 months to 9 years. CT and MRI showed not only lacunae in both hemispheres, but also deep white-matter ischemia of the centrum semi-ovale. In group II, hemiparesis or visual field defect was deteriorated early after the initial stroke. In addition, neuroimaging revealed that infarction in the posterior cerebral artery was progressed on the contralateral side, or that white matter lesion in the middle artery was enlarged in spite of small lesion in the left cerebral hemisphere. All patients in group III had deterioration of right hemiparesis associated with aphasia. CT, MRI, SPECT, and angiography indicated deep white-matter ischemia caused by main trunk lesions in the left hemisphere. Group III seemed to be equivalent to group II, except for laterality of the lesion. Neuroradiological assessment of the initial stroke may help to predict the mode of recurrence, although pathophysiology of cerebral thrombosis is complicated and varies from patient to patient. (N.K.)

  6. Stress and recurrent miscarriage.

    Science.gov (United States)

    Craig, M

    2001-09-01

    Our current understanding into the role of stress in unexplained recurrent miscarriages comes from two different research strategies. The majority of research has examined the role of psychological support within this patient population. This support has been provided in a number of ways ranging from weekly interviews with a psychiatrist or gynaecologist and or visual re-assurance in the form of ultrasound scans. A comparison of psychological support with an absence of such intervention has found differences in successful pregnancy outcome varying from as great as 84 versus 26%, respectively. It has been assumed that psychological support reduces the miscarriage rate by reducing “stress”within this patient population. In addition it provides indirect support for a role of stress in the aetiology of unexplained recurrent miscarriage. Other studies have attempted to directly assess the effect of personality characteristics on miscarriage rate; these studies have yielded conflicting results.The mechanism by which stress may be causal in the aetiology of unexplained recurrent miscarriage has not been examined in humans. Animal studies, however, have found that psychological distress can alter immune parameters that may be intricately involved with implantation. These parameters include an elevation of the “abortive” cytokine TNF-a and a reduction in the “anti-abortive” cytokine TGF-P2. Cells that are involved in the release of TNF-a at the feto-maternal interface include T cells, macrophages and mast cells.Mechanisms through which stress may act on these cells are explored and an integrated model is postulated.

  7. Strategies for Selecting Crosses Using Genomic Prediction in Two Wheat Breeding Programs.

    Science.gov (United States)

    Lado, Bettina; Battenfield, Sarah; Guzmán, Carlos; Quincke, Martín; Singh, Ravi P; Dreisigacker, Susanne; Peña, R Javier; Fritz, Allan; Silva, Paula; Poland, Jesse; Gutiérrez, Lucía

    2017-07-01

    The single most important decision in plant breeding programs is the selection of appropriate crosses. The ideal cross would provide superior predicted progeny performance and enough diversity to maintain genetic gain. The aim of this study was to compare the best crosses predicted using combinations of mid-parent value and variance prediction accounting for linkage disequilibrium (V) or assuming linkage equilibrium (V). After predicting the mean and the variance of each cross, we selected crosses based on mid-parent value, the top 10% of the progeny, and weighted mean and variance within progenies for grain yield, grain protein content, mixing time, and loaf volume in two applied wheat ( L.) breeding programs: Instituto Nacional de Investigación Agropecuaria (INIA) Uruguay and CIMMYT Mexico. Although the variance of the progeny is important to increase the chances of finding superior individuals from transgressive segregation, we observed that the mid-parent values of the crosses drove the genetic gain but the variance of the progeny had a small impact on genetic gain for grain yield. However, the relative importance of the variance of the progeny was larger for quality traits. Overall, the genomic resources and the statistical models are now available to plant breeders to predict both the performance of breeding lines per se as well as the value of progeny from any potential crosses. Copyright © 2017 Crop Science Society of America.

  8. Recurrent Bilateral Focal Myositis.

    Science.gov (United States)

    Nagafuchi, Hiroko; Nakano, Hiromasa; Ooka, Seido; Takakuwa, Yukiko; Yamada, Hidehiro; Tadokoro, Mamoru; Shimojo, Sadatomo; Ozaki, Shoichi

    This report describes a rare case of recurrent bilateral focal myositis and its successful treatment via methotrexate. A 38-year-old man presented myalgia of the right gastrocnemius in May 2005. Magnetic resonance imaging showed very high signal intensity in the right gastrocnemius on short-tau inversion recovery images. A muscle biopsy revealed inflammatory CD4+ cell-dominant myogenic change. Focal myositis was diagnosed. The first steroid treatment was effective. Tapering of prednisolone, however, repeatedly induced myositis relapse, which progressed to multiple muscle lesions of both lower limbs. Initiation of methotrexate finally allowed successful tapering of prednisolone, with no relapse in the past 4 years.

  9. Recurrent Pregnancy Loss

    Directory of Open Access Journals (Sweden)

    Véronique Piroux

    1997-01-01

    Full Text Available Antiphospholipid antibodies (APA are associated with thrombosis, thrombocytopenia and fetal loss but they occur in a variety of diseases. Despite many efforts, a correlation between the specificity of particular subgroups of APA and particular clinical situations remains to be established. The antigens at the origin of APA remain to be identified. We discuss here the possible links between cell apoptosis or necrosis, leading to plasma membrane alterations, and the occurrence of APA in response to sustained stimulation. The pathogenic potential of APA is also considered with respect to recurrent pregnancy loss.

  10. Equine recurrent airway obstruction

    Directory of Open Access Journals (Sweden)

    Artur Niedźwiedź

    2014-10-01

    Full Text Available Equine Recurrent Airway Obstruction (RAO, also known as heaves or broken wind, is one of the most common disease in middle-aged horses. Inflammation of the airway is inducted by organic dust exposure. This disease is characterized by neutrophilic inflammation, bronchospasm, excessive mucus production and pathologic changes in the bronchiolar walls. Clinical signs are resolved in 3-4 weeks after environmental changes. Horses suffering from RAO are susceptible to allergens throughout their lives, therefore they should be properly managed. In therapy the most importanthing is to eliminate dustexposure, administration of corticosteroids and use bronchodilators to improve pulmonary function.

  11. Influenza NA and PB1 Gene Segments Interact during the Formation of Viral Progeny: Localization of the Binding Region within the PB1 Gene

    Directory of Open Access Journals (Sweden)

    Brad Gilbertson

    2016-08-01

    Full Text Available The influenza A virus genome comprises eight negative-sense viral RNAs (vRNAs that form individual ribonucleoprotein (RNP complexes. In order to incorporate a complete set of each of these vRNAs, the virus uses a selective packaging mechanism that facilitates co-packaging of specific gene segments but whose molecular basis is still not fully understood. Recently, we used a competitive transfection model where plasmids encoding the A/Puerto Rico/8/34 (PR8 and A/Udorn/307/72 (Udorn PB1 gene segments were competed to show that the Udorn PB1 gene segment is preferentially co-packaged into progeny virions with the Udorn NA gene segment. Here we created chimeric PB1 genes combining both Udorn and PR8 PB1 sequences to further define the location within the Udorn PB1 gene that drives co-segregation of these genes and show that nucleotides 1776–2070 of the PB1 gene are crucial for preferential selection. In vitro assays examining specific interactions between Udorn NA vRNA and purified vRNAs transcribed from chimeric PB1 genes also supported the importance of this region in the PB1-NA interaction. Hence, this work identifies an association between viral genes that are co-selected during packaging. It also reveals a region potentially important in the RNP-RNP interactions within the supramolecular complex that is predicted to form prior to budding to allow one of each segment to be packaged in the viral progeny. Our study lays the foundation to understand the co-selection of specific genes, which may be critical to the emergence of new viruses with pandemic potential.

  12. Zinc distribution and speciation in Arabidopsis halleri x Arabidops is lyrata progenies presenting various zinc accumulation capacities

    Energy Technology Data Exchange (ETDEWEB)

    Sarret, Geraldine; Willems, Glenda; Isaure, Marie-Pierre; Marcus, Matthew A.; Fakra, Sirine C.; Frerot, Helene; Pairis, Sebastien; Geoffroy, Nicolas; Manceau, Alain; Saumitou-Laprade, Pierre

    2010-04-08

    - The purpose of this study was to investigate the relationship between the chemical form and localization of zinc (Zn) in plant leaves and their Zn accumulationcapacity. - An interspecific cross between Arabidopsis halleri sp. halleri and Arabidopsis lyrata sp. petrea segregating for Zn accumulation was used. Zinc (Zn) speciation and Zn distribution in the leaves of the parent plants and of selected F1 and F2 progenies were investigated by spectroscopic and microscopic techniques and chemical analyses. - A correlation was observed between the proportion of Zn being in octahedral coordination complexed to organic acids and free in solution (Zn?OAs + Znaq) and Zn content in the leaves. This pool varied between 40percent and 80percent of total leaf Zn depending on the plant studied. Elemental mapping of the leaves revealed different Zn partitioning between the veins and the leaf tissue. The vein : tissue fluorescence ratio was negatively correlated with Zn accumulation. - The higher proportion of Zn?OAs + Znaq and the depletion of the veins in the stronger accumulators are attributed to a higher xylem unloading and vacuolar sequestration in the leaf cells. Elemental distributions in the trichomes were also investigated, and results support the role of carboxyl and⁄ or hydroxyl groups as major Zn ligands in these cells.

  13. Radon and radon progeny in 70 houses in the Tennessee Valley area: study design and measurement methods

    International Nuclear Information System (INIS)

    Dudney, C.S.; Hawthorne, A.R.; Monar, K.P.; Quillen, J.L.; Clark, C. Jr.; Doane, R.W.; Wallace, R.G.; Reed, R.P.

    1986-01-01

    Levels of radon and its short-lived airborne progeny are being measured in a year-long study of 70 houses in four states in the Tennessee Valley. Various methods were used to solicit volunteers with differing degrees of success. Criteria for selection of houses in the study included presence of a lower level with cement floor and one or more block walls in contact with the soil, absence of obvious indications of technologically enhanced sources of radium, and proximity to one of four cities (Knoxville, Chattanooga, Birmingham, or Florence). By design, most houses in the study are in the same neighborhood as at least one other house in the study. Houses range in age from newly constructed to about 40 years old. Most of the houses have more than 2000 square feet of finished floor space. The lower level encompasses a garage in most cases. More complete information pertaining to house characteristics will be gathered in the course of the study. 19 refs., 1 fig

  14. Recurrent Ataxia in Children and Adolescents.

    Science.gov (United States)

    Salman, Michael S; Klassen, Samantha F; Johnston, Janine L

    2017-07-01

    Recurrent ataxia is encountered infrequently in clinical pediatric neurology practise and presents with diagnostic challenges. It is caused by several disorders. Our aims were to describe the epidemiology and clinical features in children with recurrent ataxia. A retrospective review was undertaken in 185 children with chronic ataxia, who presented during 1991 to 2008. Several databases were searched to ensure optimum ascertainment. Patients with brain tumors or isolated disorders of the peripheral nerves or vestibular system were excluded. Recurrent ataxia was reported in 21 patients. Their age range was between 6 and 32.75 years (males=12). The crude period prevalence rate for the 18-year study period was 7.44/100,000. Eight patients had episodic ataxia and seven had inflammatory and metabolic disorders. In the rest the etiology was unknown. Many patients presented with ataxia, dizziness, and vertigo. The frequency and duration of the ataxic episodes varied from several per day to one every few months. Other clinical features included developmental delay and seizures. Neuroimaging in episodic ataxia was normal and abnormal in inflammatory or metabolic disorders. Acetazolamide provided symptomatic relief in patients with episodic ataxia, while steroids were beneficial in patients with an inflammatory etiology. One child with a metabolic disorder died. Recurrent ataxia is an uncommon presentation in children and mortality is rare. Genetic, metabolic, and inflammatory disorders should be considered in these patients. Neuroimaging is essential. Acetazolamide in selected patients provides good symptomatic relief.

  15. Recurrent oral angioleiomyoma

    Directory of Open Access Journals (Sweden)

    V G Mahima

    2011-01-01

    Full Text Available Angioleiomyomas are vascular variant of leiomyomas which are benign tumors of smooth muscle. They are exceedingly rare in the oral cavity. Malignant transformation of these tumors has also been reported occasionally which warrants knowledge of this soft tissue tumor. A 57 year old male patient reported with a 15 day history of an asymptomatic growth that had started insidiously in his lower left back tooth region. Clinical examination revealed a solitary, oval, sessile growth in the mandibular left retro molar region. Excisional biopsy was suggestive of Angioleiomyoma. A recurrence of the same was noted two months later which was also histopathologically reported as Angioleiomyoma. The same was confirmed using special stains. This case reports an unusual presentation of Angioleiomyoma with regards to both recurrence as well as rapid growth. It is important to be well aware of this uncommon entity as these tumors often can mimic or transform into malignancy. Precise clinicopathological examinations are therefore invaluable in establishing an accurate diagnosis and delivering suitable treatment.

  16. Risk factors for recurrent vulvovaginal candidiasis

    Directory of Open Access Journals (Sweden)

    Janković Slobodan

    2010-01-01

    Full Text Available Background/Aim. Recurrent vulvovaginal candidiasis is relatively frequent condition, and may have serious health consequences, like chronic vulvovaginal pain syndrome. The aim of our study was to determine possible risk factors for recurrent vulvovaginal candidiasis in non-pregnant females within the reproductive age. Methods. The design of our study was of a case-control type. Case and control patients were selected from the gynecological patients at six primary care facilities in Serbia and in Montenegro. The data on the patients' health condition, concomitant therapy and diseases were taken from their records, and the data on habits were obtained by unstructured interview. For potential risk factors crude odds ratios were calculated, and then adjusted by logistic regression. Results. A total of fifty-one patients had four or more episodes of vulvovaginal candidiasis during the last year (cases, and 132 patients with one to three episodes of vulvovaginal candidiasis were sampled as controls, matched by age. The only two significant associations were found between recurrent vulvovaginal candidiasis and continual wearing of panty liners during the last year (Odds ratio - ORadjusted: 3.97; confidence interval - CI: 1.57-10.02; p = 0.004, and between recurrent vulvovaginal candidiasis and predominant use of vaginal tampons during menstruation in the last year (ORadjusted: 4.25; CI: 1.11-16.27; p = 0.035. The synergistic effect was observed for the concurrent continual wearing of panty liners during the last year and selfmedication with antimycotics. Conclusions. Local factors, like wearing of panty liners or use of tampons during menstruation, may promote recurrence of vulvovaginal candidiasis, especially in patients who practice selfmedication with antimycotics.

  17. Changes in the rat lung after exposure to radon and its progeny: Effects on incorporation of bromodeoxyuridine in epithelial cells and on the incidence of nuclear aberrations in Alveolar macrophages

    International Nuclear Information System (INIS)

    Taya, A.; Morgan, A.; Baker, S.T.; Humphreys, J.A.H.; Collier, C.G.; Bisson, M.

    1994-01-01

    The aim of this study was to investigate some responses of cells in the rat respiratory tract as a function of time after inhalation exposure to various levels of radon and its progeny. Rats were exposed to a constant concentration of radon and its progeny to give cumulative exposure levels of 120, 225, 440 and 990 working level months (WLM). An additional unexposed group of rats served as controls. The end points selected for investigation were (a) the incorporation of bromodeoxyuridine (BrdU) in epithelial cells of the conducting airways and of the alveolar region of the respiratory tract and (b) the incidence of alveolar macrophages with nuclear aberrations. After exposure, the incidence of epithelial cells incorporating BrdU-the labeling index-increased in all regions of the respiratory tract examined, but the increase occurred later in alveolar than in airway epithelial cells. The highest labeling index was found in bronchial epithelial cells, which probably received the highest radiation dose. After an initial induction period, the incidence of alveolar macrophages with nuclear aberrations also increased. The possibility of using the labeling index of alveolar and airway epithelial cells, and/or the incidence of nuclear aberrations in alveolar macrophages, to estimate the radiation dose to various regions of the respiratory tract after exposure of rats to radon and its progeny is discussed. 22 refs., 3 figs., 1 tab

  18. A review of lung-to-blood absorption rates for radon progeny

    International Nuclear Information System (INIS)

    Marsh, J. W.; Bailey, M. R.

    2013-01-01

    The International Commission on Radiological Protection (ICRP) Publication 66 Human Respiratory Tract Model (HRTM) treats clearance of materials from the respiratory tract as a competitive process between absorption into blood and particle transport to the alimentary tract and lymphatics. The ICRP recommended default absorption rates for lead and polonium (Type M) in ICRP Publication 71 but stated that the values were not appropriate for short-lived radon progeny. This paper reviews and evaluates published data from volunteer and laboratory animal experiments to estimate the HRTM absorption parameter values for short-lived radon progeny. Animal studies showed that lead ions have two phases of absorption: ∼10 % absorbed with a half-time of ∼15 min, the rest with a half-time of ∼10 h. The studies also indicated that some of the lead ions were bound to respiratory tract components. Bound fractions, f b , for lead were estimated from volunteer and animal studies and ranged from 0.2 to 0.8. Based on the evaluations of published data, the following HRTM absorption parameter values were derived for lead as a decay product of radon: f r = 0.1, s r = 100 d -1 , s s = 1.7 d -1 , f b = 0.5 and s b = 1.7 d -1 . Effective doses calculated assuming these absorption parameter values instead of a single absorption half-time of 10 h with no binding (as has generally been assumed) are only a few per cent higher. However, as there is some conflicting evidence on the absorption kinetics for radon progeny, dose calculations have been carried out for different sets of absorption parameter values derived from different studies. The results of these calculations are discussed. (authors)

  19. Azadirachtin effects on mating success, gametic abnormalities and progeny survival in Drosophila melanogaster (Diptera).

    Science.gov (United States)

    Oulhaci, Chemseddine M; Denis, Béatrice; Kilani-Morakchi, Samira; Sandoz, Jean-Christophe; Kaiser, Laure; Joly, Dominique; Aribi, Nadia

    2018-01-01

    Azadirachtin is a prominent natural pesticide and represents an alternative to conventional insecticides. It has been successfully used against insect pests. However, its effects on reproduction require further analysis. Here we investigated lethal and sublethal effects of azadirachtin, on treated adults in a model insect, Drosophila melanogaster (Meigen). Dose-mortality relationships as well as several parameters of reproduction (mating, spermatogenesis, oogenesis and fertility) were examined. Neem-Azal, a commercial formulation of azadirachtin, applied topically on newly emerged adults, increased mortality with a positive dose-dependent relationship. The LD 50 (0.63 μg) was determined 24 h after treatment using a non-linear regression. Adults surviving this dose had a mating success that was divided by 3 and a progeny production reduced by half when males were treated, and even more when females were treated. When combining probability of survival, of mating and reduced progeny, it appeared that LD 50 induced a 98% reduction in reproductive rates. Reduced progeny was partially explained by the effect of adult treatment on gametes number and abnormalities. The number of cysts and the apical nuclei positions within the cysts decreased by 29.7% and 20%, respectively, in males. In females, the number of oocytes per ovary and the volume of basal oocytes also decreased by 16.1% and 32.4%, respectively. Azadirachtin causes significant toxic effects in both sexes and decreases the fecundity and fertility of D. melanogaster. Females are more sensitive to azadirachtin. © 2017 Society of Chemical Industry. © 2017 Society of Chemical Industry.

  20. Effect of indoor-generated airborne particles on radon progeny dynamics

    Energy Technology Data Exchange (ETDEWEB)

    Trassierra, C. Vargas [Department of Civil and Mechanical Engineering, University of Cassino and Southern Lazio, Cassino, FR (Italy); Stabile, L., E-mail: l.stabile@unicas.it [Department of Civil and Mechanical Engineering, University of Cassino and Southern Lazio, Cassino, FR (Italy); Cardellini, F.; Morawska, L. [National Institute of Ionizing Radiation Metrology (INMRI-ENEA), Rome (Italy); Buonanno, G. [Department of Civil and Mechanical Engineering, University of Cassino and Southern Lazio, Cassino, FR (Italy); International Laboratory for Air Quality and Health, Queensland University of Technology, Brisbane (Australia)

    2016-08-15

    Highlights: • Investigation of the interaction between particles and radon progeny dynamics. • Measurements of particles emitted by different indoor sources. • Tests performed in a controlled radon chamber. • Particle size strongly influences the radon progeny dynamics. • Particle surface area concentration is the key parameter of the radon-particle interaction. - Abstract: In order to investigate the interaction between radon progeny and particles, an experimental campaign was carried out in a radon chamber at the Italian National Institute of Ionizing Radiation Metrology, quantifying the amount of attached and unattached radon daughters present in air, as well as the equilibrium factor in the presence of particles generated through indoor sources. A fixed radon concentration was maintained, while particles were generated using incense sticks, mosquito coils and gas combustion. Aerosols were characterized in terms of particle concentrations and size distributions. Simultaneously, radon concentration and attached/unattached potential alpha energy concentration in the air were continuously monitored by two different devices, based on alpha spectroscopy techniques. The presence of particles was found to affect the attached fraction of radon decay products, in such a way that the particles acted as a sink for radionuclides. In terms of sources which emit large particles (e.g. incense, mosquito coils), which greatly increase particle surface area concentrations, the Equilibrium Factor was found to double with respect to the background level before particle generation sessions. On the contrary, the radon decay product dynamics were not influenced by gas combustion processes, mainly due to the small surface area of the particles emitted.

  1. Treatment Outcomes and Prognostic Factors After Recurrence of Esophageal Squamous Cell carcinoma.

    Science.gov (United States)

    Hamai, Yoichi; Hihara, Jun; Emi, Manabu; Furukawa, Takaoki; Ibuki, Yuta; Yamakita, Ichiko; Kurokawa, Tomoaki; Okada, Morihito

    2017-12-29

    The evaluation of treatment outcomes and detection of prognostic factors after recurrence are very important for tailoring optimal therapies for individual patients with recurrent esophageal cancer. We reviewed 133 patients in whom esophageal squamous cell carcinoma (ESCC) recurred after curative surgery, and assessed recurrence patterns, treatment outcomes and prognostic factors. Recurrence in 57 (42.9%), 54 (40.6%) and 22 (16.5%) patients was locoregional, distant and combined, respectively. The median amounts of elapsed time until recurrence and median survival after recurrence for all patients were 9.1 and 8.3 months, respectively. Univariate and multivariate analyses selected time to recurrence (hazard ratio [HR], 0.98; 95% confidence interval [CI], 0.97-0.999; p = 0.04), recurrence location (locoregional vs. distant: HR, 1.63; 95% CI, 1.03-2.61; p = 0.04), number of organs with recurrence (1 vs. 3: HR, 3.49; 95% CI, 1.23-9.87; p = 0.02) and treatment after recurrence (best supportive care, [BSC] vs. chemotherapy [CT] or radiation therapy [RT]: HR, 0.37; 95% CI, 0.15-0.94; p = 0.04; BSC vs. CT and RT: HR, 0.50; 95% CI, 0.26-0.94; p = 0.03; BSC vs. HR, 0.47; 95% CI, 0.25-0.88; p = 0.02) as independent factors for survival after recurrence. Seventeen (12.8%) patients who had localized lymph node recurrence and lung oligometastasis and received multidisciplinary therapy after recurrence survived for >3 years thereafter. Despite the poor survival of patients with ESCC and early or distant recurrence or recurrence in ≥3 recurrent organs, appropriate multimodal therapies should be tailored for individual patients with recurrent ESCC.

  2. Recurrent pregnancy loss

    DEFF Research Database (Denmark)

    Egerup, P; Kolte, A M; Larsen, E C

    2016-01-01

    STUDY QUESTION: Is there a different prognostic impact for consecutive and non-consecutive early pregnancy losses in women with secondary recurrent pregnancy loss (RPL)? SUMMARY ANSWER: Only consecutive early pregnancy losses after the last birth have a statistically significant negative prognostic...... impact in women with secondary RPL. WHAT IS KNOWN ALREADY: The risk of a new pregnancy loss increases with the number of previous pregnancy losses in patients with RPL. Second trimester losses seem to exhibit a stronger negative impact than early losses. It is unknown whether the sequence of pregnancy...... losses plays a role for the prognosis in patients with a prior birth. STUDY DESIGN, SIZE, DURATION: This retrospective cohort study of pregnancy outcome in patients with unexplained secondary RPL included in three previously published, Danish double-blinded placebo-controlled trials of intravenous...

  3. Recurrent Spatial Transformer Networks

    DEFF Research Database (Denmark)

    Sønderby, Søren Kaae; Sønderby, Casper Kaae; Maaløe, Lars

    2015-01-01

    We integrate the recently proposed spatial transformer network (SPN) [Jaderberg et. al 2015] into a recurrent neural network (RNN) to form an RNN-SPN model. We use the RNN-SPN to classify digits in cluttered MNIST sequences. The proposed model achieves a single digit error of 1.5% compared to 2.......9% for a convolutional networks and 2.0% for convolutional networks with SPN layers. The SPN outputs a zoomed, rotated and skewed version of the input image. We investigate different down-sampling factors (ratio of pixel in input and output) for the SPN and show that the RNN-SPN model is able to down-sample the input...

  4. Recurrent Aggressive Angiomyxoma*

    Directory of Open Access Journals (Sweden)

    Suelene Suassuna Silvestre de Alencar

    2013-10-01

    Full Text Available Introduction: aggressive angiomyxoma is a highly aggressive, rare neoplasm of the mesen- chymal tissue with a high recurrence rate. It represents an important differential diagnosis of pelvic tumors in women of reproductive age. This study aims to describe a case of ag- gressive angiomyxoma.Case report: woman, 37 years old, complained about a bulge on the right perianal region, and anal itching and burning, bleeding, tenesmus and incontinence. The proctologic examina- tion confirmed the perianal bulge and extrinsic compression of the posterior wall of the rectum. Computed tomography (CT of the pelvis showed a well-defined pelvic mass ex- tending to the right rectal area. Exploratory laparotomy showed a mass of fibro elastic con- sistency adjacent to the pelvic organs and closely attached to the distal rectum, and per- formed a resection of the pelvic tumor afterward. Anatomopathological analysis revealed an aggressive angiomyxoma. Magnetic resonance imaging (MRI of the pelvis showed signs of recurrence in the pelvic cavity on the right side of the rectum. A surgical procedure was performed to resect the lesion. After an asymptomatic period, the MRI showed solid growths located in the right ischiorectal fossa. A new surgical procedure identified only retention cysts in the pelvis and right ischiorectal fossa, only lysis of adhesions was per- formed. The patient is currently undergoing follow-up without disease recurrence. Resumo: Introdução: o angiomixoma agressivo é uma rara neoplasia do tecido mesenquimal de gran- de agressividade e alta taxa de recorrência. Representa um importante diagnóstico diferen- cial de tumorações pélvicas de mulheres em idade reprodutiva. Este estudo objetiva relatar um caso de angiomixoma agressivo.Relato de caso: mulher, 37 anos, com queixa de abaulamento em região perianal direita, além de prurido e ardor anal, sangramento, tenesmo e incontinência anal. Exame procto- lógico confirmou o abaulamento

  5. Analysis of Brain Recurrence

    Science.gov (United States)

    Frilot, Clifton; Kim, Paul Y.; Carrubba, Simona; McCarty, David E.; Chesson, Andrew L.; Marino, Andrew A.

    Analysis of Brain Recurrence (ABR) is a method for extracting physiologically significant information from the electroencephalogram (EEG), a non-stationary electrical output of the brain, the ultimate complex dynamical system. ABR permits quantification of temporal patterns in the EEG produced by the non-autonomous differential laws that govern brain metabolism. In the context of appropriate experimental and statistical designs, ABR is ideally suited to the task of interpreting the EEG. Present applications of ABR include discovery of a human magnetic sense, increased mechanistic understanding of neuronal membrane processes, diagnosis of degenerative neurological disease, detection of changes in brain metabolism caused by weak environmental electromagnetic fields, objective characterization of the quality of human sleep, and evaluation of sleep disorders. ABR has important beneficial implications for the development of clinical and experimental neuroscience.

  6. Oncologic outcome and patterns of recurrence after salvage radical prostatectomy.

    Science.gov (United States)

    Paparel, Philippe; Cronin, Angel M; Savage, Caroline; Scardino, Peter T; Eastham, James A

    2009-02-01

    Limited data on patterns of recurrence (local or metastatic) after salvage radical prostatectomy (SP) is available. To examine biochemical, local and metastatic patterns of recurrence in patients undergoing SP for radiation-recurrent prostate cancer. 146 patients with biopsy-proven local recurrence of prostate cancer after radiation therapy treated with SP were evaluated in a retrospective study at a single institution. All patients underwent SP by mainly two surgeons. Biochemical recurrence (BCR) after SP was defined as a serum prostate-specific antigen (PSA) level of >or=0.2 ng/ml or was defined by the initiation of androgen deprivation therapy. All predictors analyzed were determined after radiotherapy, before SP, and included PSA level, clinical stage, biopsy Gleason score, age at SP, and time interval from radiotherapy to SP. Of the 146 patients treated with SP, 65 developed BCR. The median follow-up period for recurrence-free patients was 3.8 yr; 43 patients (29%) were followed for >5 yr. Overall, the 5-yr recurrence-free probability was 54% (95% CI, 44-63%). Clinical local recurrence occurred in only one patient who also had bone metastases. Overall, there were 16 prostate cancer-specific deaths and 19 deaths from other causes. The 5-yr cumulative incidence of death from prostate cancer was 4% (95% CI, 2-11%). Pre-SP serum PSA level and biopsy Gleason score were significantly associated with death due to prostate cancer (p<0.0005 and p=0.002, respectively). This study is retrospective and included carefully selected patients treated over a long period by, mainly, two experienced surgeons. SP provides excellent local cancer control; only one patient in our series experienced a clinical local recurrence. Earlier identification of patients with persistent, viable local cancer despite radiation therapy will appropriately select patients for SP.

  7. Measurement of the size distributions of radon progeny in indoor air

    International Nuclear Information System (INIS)

    Hopke, P.K.; Ramamurthi, M.; Li, C.S.

    1990-01-01

    A major problem in evaluating the health risk posed by airborne radon progeny in indoor atmospheres is the lack of available information on the activity-weighted size distributions that occur in the domestic environment. With an automated, semicontinuous, graded screen array system, we made a series of measurements of activity-weighted size distributions in several houses in the northeastern United States. Measurements were made in an unoccupied house, in which human aerosol-generating activities were simulated. The time evolution of the aerosol size distribution was measured in each situation. Results of these measurements are presented

  8. Submicron-sized aerosol and radon progeny measurements in an uranium mine

    International Nuclear Information System (INIS)

    Boulaud, D.; Chouard, J.C.

    1992-01-01

    Submicron-sized aerosol was studied in an uranium mine using an Electrical Aerosol Analyzer and a Differential Mobility Particle Sizer. In addition radon progeny particle size distributions were measured using a prototype instrument developed by us (SDI 2000). With cascade impactor the number weighted mean electrical mobility diameters and the geometric standard deviations ranged respectively from 0.05 to 0.1 μm and 1.8 to 2. The gross alpha activity weighted mean thermodynamic diameters ranged typically from 0.1 to 0.2 μm. 6 refs., 3 figs

  9. Development of a Progeny Marker for Steelhead; A Thesis submitted to Oregon State University.

    Energy Technology Data Exchange (ETDEWEB)

    Shippentower, Gene E. [Oregon State Univ., Corvallis, OR (United States)

    2009-04-15

    This study was undertaken to determine if strontium chloride could be used to create a trans-generational otolith mark in steelhead (Oncorhynchus mykiss). I completed two strontium injection trials and a survey of juvenile steelhead from various steelhead hatcheries. The two trials measured Sr:Ca ratios in otoliths in response to injections and the survey measured the natural variation in Sr:Ca ratios in otoliths of juvenile hatchery steelhead in response to the natural variation. In 2003, adult female Wallowa River, Oregon O. mykiss, were captured at the hatchery and evenly divided between a control group and two treatment groups. These females received an intraperitoneal injection of 1cc/500 g of body weight of a physiologically isotonic solution (0.9% saline) containing concentrations of 0 (control), 1000, or 5000 parts per million (ppm) of strontium chloride hexahydrate (SrCl2* 6H2O). Females were housed in a single outdoor tank until spawned artificially, and a distinct external tag identified each female within each treatment group. In 2004, female steelhead were captured throughout the duration of the adult returns to the Umatilla River basin and injected with 0, 1000, 5000, or 20,000-ppm strontium. In both trials, progeny of fish treated with strontium had significantly higher Sr:Ca ratios in the primordial region of their otoliths as measured using an electron wavelength dispersive microprobe. There was no difference in fertilization rates of eggs and survival rates of fry among treatment groups. Progeny from treated mothers were on average larger than progeny of untreated mothers. The Sr:Ca ratios in otoliths collected from various populations of steelhead were greater than the control values measured in both injections studies. This study suggests that the marking technique works and the utility for such a technique could be used for empirical observations in determining the relative fitness of progeny of adult hatchery origin fish

  10. The Progeny Test Half-Sib Paraserianthes falcataria L. Nielsen at Taman Hutan Blok Cikabayan

    Directory of Open Access Journals (Sweden)

    Ali Mukmin

    2012-09-01

    Full Text Available 800x600 Analysis of genetic parameters in seedling seed orchard progeny trial of Paraserianthes falcataria at Taman Hutan Blok Cikabayan are very important to decide to continue  the breeding program.  The analysis was coducted on estimation of individual heritability and genetic correlation between traits. Result of analysis shows that individual heritability for height, diameter and form traits.  Normal 0 false false false IN X-NONE X-NONE MicrosoftInternetExplorer4

  11. Determination of equilibrium factor between radon and its progeny using surface barrier detector for various shapes of passive radon dosimeters

    Energy Technology Data Exchange (ETDEWEB)

    Jamil, K. [PINSTECH, Islamabad (Pakistan). Environ. Radiat. Group; Fazal-ur-Rehman [PINSTECH, Islamabad (Pakistan). Environ. Radiat. Group; Ali, S. [PINSTECH, Islamabad (Pakistan). Environ. Radiat. Group; Khan, H.A. [PINSTECH, Islamabad (Pakistan). Environ. Radiat. Group

    1997-03-21

    In the field of radon dosimetry, it is customary to measure radon ({sup 222}Rn) concentration while potential health hazard is due to the radon short-lived progeny. When radon is in secular equilibrium, the measured activity of radon equals the activity of radon`s progeny. However, in practical cases an inequilibrium between radon and its progeny exists which is measured in terms of the equilibrium factor. To determine the equilibrium factor between radon and its progeny in a closed environment various shapes of passive dosimeters based upon solid state nuclear track detectors (SSNTDs) are employed. In order to observe the dependence of equilibrium factor upon shapes or effective volumes, experiments have been performed replacing the SSNTDs with a surface barrier detector in Karlsruhe diffusion chamber, pen-type and box-type dosimeters. Using the collected alpha spectra, the equilibrium factor has been determined for a radon-air mixture in a custom designed radon chamber simulating a closed environment of a room. The results show that the radon equilibrium factor is about 0.20 for different shapes of dosimeters studied in this research. It is concluded that the determination of equilibrium factor between radon and its progeny does not depend upon effective volume or shape of the passive dosimeters using alpha spectroscopic data acquired by surface barrier detector. (orig.).

  12. Determination of equilibrium factor between radon and its progeny using surface barrier detector for various shapes of passive radon dosimeters

    International Nuclear Information System (INIS)

    Jamil, K.; Fazal-ur-Rehman; Ali, S.; Khan, H.A.

    1997-01-01

    In the field of radon dosimetry, it is customary to measure radon ( 222 Rn) concentration while potential health hazard is due to the radon short-lived progeny. When radon is in secular equilibrium, the measured activity of radon equals the activity of radon's progeny. However, in practical cases an inequilibrium between radon and its progeny exists which is measured in terms of the equilibrium factor. To determine the equilibrium factor between radon and its progeny in a closed environment various shapes of passive dosimeters based upon solid state nuclear track detectors (SSNTDs) are employed. In order to observe the dependence of equilibrium factor upon shapes or effective volumes, experiments have been performed replacing the SSNTDs with a surface barrier detector in Karlsruhe diffusion chamber, pen-type and box-type dosimeters. Using the collected alpha spectra, the equilibrium factor has been determined for a radon-air mixture in a custom designed radon chamber simulating a closed environment of a room. The results show that the radon equilibrium factor is about 0.20 for different shapes of dosimeters studied in this research. It is concluded that the determination of equilibrium factor between radon and its progeny does not depend upon effective volume or shape of the passive dosimeters using alpha spectroscopic data acquired by surface barrier detector. (orig.)

  13. Imaging of prostate cancer local recurrences: why and how?

    International Nuclear Information System (INIS)

    Rouviere, Olivier; Lyonnet, Denis; Vitry, Thierry

    2010-01-01

    Because prostate cancer local recurrences can be efficiently treated by salvage therapies, it becomes critical to detect them early. The first alert is the rise of the prostate specific antigen (PSA) level after the post-treatment nadir, which can correspond to a distant recurrence, a local recurrence or both. This so-called biochemical failure (BF) is defined as PSA level >0.2 ng/ml after radical prostatectomy (RP) and PSA level > nadir+2 ng/ml after radiotherapy. There is no consensual definition of BF after cryotherapy, high-intensity focused ultrasound (HIFU) ablation or brachytherapy. Local recurrences after RP are treated by radiotherapy, those after radiotherapy by RP, cryotherapy, brachytherapy or HIFU ablation. Recurrences after cryotherapy or HIFU ablation can be treated by a second session or radiotherapy. Recurrences after brachytherapy are difficult to treat. In patients with BF, MRI can detect local recurrences, whatever the initial treatment was. Dynamic contrast-enhanced MRI seems particularly accurate. The role of spectroscopy remains controversial. Ultrasound-based techniques are less accurate, but this may change with the advent of ultrasonic contrast media. These recent advances in imaging may improve the outcome of salvage therapies (by improving patient selection and treatment targeting) and should open the way to focal salvage treatments in the near future. (orig.)

  14. Imaging of prostate cancer local recurrences: why and how?

    Energy Technology Data Exchange (ETDEWEB)

    Rouviere, Olivier; Lyonnet, Denis [Universite de Lyon, Lyon (France); Universite Lyon 1, Faculte de Medecine Lyon Nord (France); Service d' Imagerie Urinaire et Vasculaire, Hospices Civils de Lyon, Hopital Edouard Herriot, Lyon (France); INSERM U 556, Lyon (France); Vitry, Thierry [Service d' Imagerie Urinaire et Vasculaire, Hospices Civils de Lyon, Hopital Edouard Herriot, Lyon (France)

    2010-05-15

    Because prostate cancer local recurrences can be efficiently treated by salvage therapies, it becomes critical to detect them early. The first alert is the rise of the prostate specific antigen (PSA) level after the post-treatment nadir, which can correspond to a distant recurrence, a local recurrence or both. This so-called biochemical failure (BF) is defined as PSA level >0.2 ng/ml after radical prostatectomy (RP) and PSA level > nadir+2 ng/ml after radiotherapy. There is no consensual definition of BF after cryotherapy, high-intensity focused ultrasound (HIFU) ablation or brachytherapy. Local recurrences after RP are treated by radiotherapy, those after radiotherapy by RP, cryotherapy, brachytherapy or HIFU ablation. Recurrences after cryotherapy or HIFU ablation can be treated by a second session or radiotherapy. Recurrences after brachytherapy are difficult to treat. In patients with BF, MRI can detect local recurrences, whatever the initial treatment was. Dynamic contrast-enhanced MRI seems particularly accurate. The role of spectroscopy remains controversial. Ultrasound-based techniques are less accurate, but this may change with the advent of ultrasonic contrast media. These recent advances in imaging may improve the outcome of salvage therapies (by improving patient selection and treatment targeting) and should open the way to focal salvage treatments in the near future. (orig.)

  15. Identification of QTL for UV-protective eye area pigmentation in cattle by progeny phenotyping and genome-wide association analysis.

    Directory of Open Access Journals (Sweden)

    Hubert Pausch

    Full Text Available Pigmentation patterns allow for the differentiation of cattle breeds. A dominantly inherited white head is characteristic for animals of the Fleckvieh (FV breed. However, a minority of the FV animals exhibits peculiar pigmentation surrounding the eyes (ambilateral circumocular pigmentation, ACOP. In areas where animals are exposed to increased solar ultraviolet radiation, ACOP is associated with a reduced susceptibility to bovine ocular squamous cell carcinoma (BOSCC, eye cancer. Eye cancer is the most prevalent malignant tumour affecting cattle. Selection for animals with ACOP rapidly reduces the incidence of BOSCC. To identify quantitative trait loci (QTL underlying ACOP, we performed a genome-wide association study using 658,385 single nucleotide polymorphisms (SNPs. The study population consisted of 3579 bulls of the FV breed with a total of 320,186 progeny with phenotypes for ACOP. The proportion of progeny with ACOP was used as a quantitative trait with high heritability (h(2 = 0.79. A variance component based approach to account for population stratification uncovered twelve QTL regions on seven chromosomes. The identified QTL point to MCM6, PAX3, ERBB3, KITLG, LEF1, DKK2, KIT, CRIM1, ATRN, GSDMC, MITF and NBEAL2 as underlying genes for eye area pigmentation in cattle. The twelve QTL regions explain 44.96% of the phenotypic variance of the proportion of daughters with ACOP. The chromosomes harbouring significantly associated SNPs account for 54.13% of the phenotypic variance, while another 19.51% of the phenotypic variance is attributable to chromosomes without identified QTL. Thus, the missing heritability amounts to 7% only. Our results support a polygenic inheritance pattern of ACOP in cattle and provide the basis for efficient genomic selection of animals that are less susceptible to serious eye diseases.

  16. Need for an integrated approach towards the assessment of radon, thoron and their progeny exposures

    International Nuclear Information System (INIS)

    Mayya, Y.S.

    2008-01-01

    Recent publications dealing with epidemiological studies on North American and European populations have indicated statistically significant lung cancer risk coefficients attributable to residential radon exposures. These are essentially based on radon gas itself as the quantitative measure of exposures. However, considering that true exposures depend upon the intricate mechanisms of decay product deposition in the lung, it is necessary to go for the assessment of decay products including their size distributions and deposition velocities. This approach is essential for assessing the risks of thoron and its decay products which is of considerable importance in the public domain and in the thorium fuel cycle. The recent development of deposition based progeny concentration measurement techniques appear to be best suited for radiological risk assessments both among occupational workers and general study populations. These provide an easy to wear alternative for radon inhalation dosimetry similar to TLDs for external gamma radiations. It is urgently required to characterize their performance under a variety of residential indoor and workplace conditions. This may be achieved through an integrated multi-parametric study programme involving measurements of radon, thoron and their progeny concentrations along with fine and coarse fractions and indoor source terms. This will not only in delineate the true exposure profiles and indoor parameters (e.g. deposition velocities and air exchange rates) in the country, but also will help in establishing deposition dosimetry as a basic technique for inhalation exposure estimations for occupational workers and subjects living in high background radiation areas

  17. Internal microdosimetry of inhaled radon progeny in bronchial airways: advantages and limitations

    International Nuclear Information System (INIS)

    Hofmann, Werner; Fakir, Hatim; Pihet, Pascal

    2007-01-01

    The objective of the present study was to identify advantages and limitations of the application of microdosimetric concepts for inhaled radon progeny activities in the lungs. The methods employed for this analysis were a recently developed Monte- Carlo microdosimetry code for the calculation of energy deposition in bronchial target cells and the Probability Per Unit Track Length (PPUTL) model, which relates these microdosimetric parameters to cellular radiation effects. The major advantages of internal microdosimetry of radon progeny in bronchial airways are: (i) quantitative characterisation of non-uniform dose distributions and identification of target sites with enhanced carcinogenic potential, (ii) quantification of low doses of alpha particles by the number of cells hit and the dose received by those cells, (iii) illustration of the random variations of cellular doses by specific energy distributions and (iv) establishment of a direct link to cellular radiobiological effects. At present, a major limitation of microdosimetry is the extrapolation of the response of individual cells to the resulting tissue response, which is still not fully explored. (authors)

  18. Inheritance of fruit colour in normal and irradiated progenies of brinjal

    International Nuclear Information System (INIS)

    Gopimony, R.; George, M.K.; Gopinathan Nair, V.

    1980-01-01

    The inheritance of fruit colour in brinjal (Solanum melongena) was studied by analysing the progeny belonging to the F 1 M 2 , F 1 M 1 and F 2 M 2 generations resulting from a cross between varieties insanum and purple giant followed by gamma irradiation. The F 2 phenotypic frequencies fitted very well with the dihybrid ratio indicating that the fruit colour is governed by two independently inherited genes. Three colour mutants, namely, purple, mottled green and white were induced in the F 1 M 1 generation by the irradiation. The appearance of these mutants is explained as due to independent mutations at either or both of the two goenetic loci. The colour pattern in the F 2 M 2 progenies derived from the F 1 M 1 mutants substantiates the two gene mechanism for the inheritance of fruit colour. The genotypes for the different colour types in the F 1 , F 2 and F 1 M 1 mutants have been indicated and discussed. (author)

  19. Characteristics of indoor radon and its progeny in a Japanese dwelling while using air appliances

    International Nuclear Information System (INIS)

    Pornnumpa, C.; Tokonami, S.; Sorimachi, A.; Kranrod, C.

    2015-01-01

    Characteristics of radon and its progeny were investigated in different air conditions by turning four types of indoor air appliances on and off in a two-story concrete Japanese dwelling. The four appliances were air conditioner, air cleaner, gas heater and cooker hood. The measurements were done using two devices: (1) a Si-based semiconductor detector for continuous measurement of indoor radon concentration and (2) a ZnS(Ag) scintillation counting system for equilibrium-equivalent radon concentration. Throughout the entire experiment, the cooker hood was the most effective in decreasing indoor radon concentration over a long period of time and the less effective was the air conditioner, while the air cleaner and gas heater did not affect the concentration of radon. However, the results measured in each air condition will differ according to the lifestyles and activities of the inhabitants. In this study, indoor radon and its progeny in a Japanese dwelling will be characterised by the different air conditions. (authors)

  20. Age and sex dependent inhalation doses to members of the public from indoor thoron progeny

    Energy Technology Data Exchange (ETDEWEB)

    Bi, L; Tschiersch, J [Helmholtz Zentrum Muenchen-German Research Center for Environmental Health, Institute of Radiation Protection, D-85764, Neuherberg (Germany); Li, W B [Helmholtz Zentrum Muenchen-German Research Center for Environmental Health, Department of Medical Radiation Physics and Diagnostics, D-85764, Neuherberg (Germany); Li, J L, E-mail: bilei1983@gmail.com [Department of Engineering Physics, Tsinghua University, Beijing 100084 (China)

    2010-12-01

    The increased indoor thoron level in Europe, North America and Asia has shown that the exposure to thoron and its decay products cannot be ignored in some environments. The contribution of thoron and its progeny can be a significant component of the total exposure from radon and thoron. In the present paper, radiation dose assessment of members of the public of different age and sex exposed to {sup 220}Rn progeny under different daily life activities is performed through a dosimetric approach. Dose conversion coefficients under typical indoor conditions were estimated to be in the range of 107 nSv (Bq h m{sup -3}){sup -1} for infant to 81.7 nSv (Bq h m{sup -3}){sup -1} for adult. The results of this work emphasized that small children receive a radiation dose of 25% more than adults under the same conditions, and people performing exercise receive a radiation dose 100% more than when sleeping. The results of this work are appropriate to the risk assessment of thoron exposure to members of the public who live in areas with high radon and thoron concentrations.

  1. Inversion of the Jacobi-Porstendorfer room model for the radon progeny

    International Nuclear Information System (INIS)

    Thomas, J.; Jilek, K.; Brabec, M.

    2010-01-01

    The Jacobi-Porstendoerfer (J-P) room model describes the behaviour of radon progeny in the atmosphere of a room. It distinguishes between free and attached radon progeny in air. It has been successfully used without substantial changes for nearly 40 years. There have been several attempts to invert the model approximately to determine the parameters describing the physical processes. Here, an exact solution is aimed at as an algebraic inversion of the system of six linear equations for the five unknown physical parameters k, X, R, q f , q a of the room model. Two strong linear dependencies in this system, unfortunately do not allow to obtain a general solution (especially not for the ventilation coefficient k), but only a parameterized one or for reduced sets of unknown parameters. More, the impossibility to eliminate one of the two linear dependencies and the departures of the measured concentrations forces to solve a set of allowed combinations of equations of the algebraic system and to accept its mean values (therefore with variances) as a result of the algebraic inversion. These results are in agreement with results of the least squares method as well as of a sophisticated modern statistical approach. The algebraic approach provides, of course, a lot of analytical relations to study the mutual dependencies between the model parameters and the measurable quantities. (authors)

  2. Levels of radon gas concentration and progeny in homes of Potosi City, Bolivia to 4000 m

    International Nuclear Information System (INIS)

    Mamani M, R.; Claros J, J.; Vasquez A, R.

    2015-10-01

    Full text: In this work the presence of radon gas was determined, which is a radioactive contaminant that comes from underground, able to penetrate the houses. The danger is that when mixed air and when inhaled can cause serious damage to the lungs, for the short life time that has radon and progeny for decay, damaging the pulmonary alveoli and reducing breathing capacity of the habitants, then causing polycythemia in some cases. The study was carried out in homes in the city of Potosi, Bolivia located at 4000 m. The quantification of radon gas and progeny was performed with the equipment Alpha-Zaeller-2 (Az-2), quantification was realized in 6 zones of the city of Potosi, chosen randomly. In each zone were carried out measurements in 40 homes (2 rooms more permanent), both day and night, for a period of 3 days in two different seasons and with concentrations of average humidity of 20, 50 and 80%. The values obtained for each period vary depending on the season and 30 to 50% of the allowable values given by the EPA and Who for housing. (Author)

  3. Sex determination in beetles: Production of all male progeny by Parental RNAi knockdown of transformer

    Science.gov (United States)

    Shukla, Jayendra Nath; Palli, Subba Reddy

    2012-01-01

    Sex in insects is determined by a cascade of regulators ultimately controlling sex-specific splicing of a transcription factor, Doublesex (Dsx). We recently identified homolog of dsx in the red flour beetle, Tribolium castaneum (Tcdsx). Here, we report on the identification and characterization of a regulator of Tcdsx splicing in T. castaneum. Two male-specific and one female-specific isoforms of T. castaneum transformer (Tctra) were identified. RNA interference-aided knockdown of Tctra in pupa or adults caused a change in sex from females to males by diverting the splicing of Tcdsx pre-mRNA to male-specific isoform. All the pupa and adults developed from Tctra dsRNA injected final instar larvae showed male-specific sexually dimorphic structures. Tctra parental RNAi caused an elimination of females from the progeny resulting in production of all male progeny. Transformer parental RNAi could be used to produce all male population for use in pest control though sterile male release methods. PMID:22924109

  4. Saturated very long chain fatty acids are required for the production of infectious human cytomegalovirus progeny.

    Directory of Open Access Journals (Sweden)

    Emre Koyuncu

    Full Text Available Human cytomegalovirus hijacks host cell metabolism, increasing the flux of carbon from glucose to malonyl-CoA, the committed precursor to fatty acid synthesis and elongation. Inhibition of acetyl-CoA carboxylase blocks the production of progeny virus. To probe further the role of fatty acid metabolism during infection, we performed an siRNA screen to identify host cell metabolic enzymes needed for the production of infectious cytomegalovirus progeny. The screen predicted that multiple long chain acyl-CoA synthetases and fatty acid elongases are needed during infection, and the levels of RNAs encoding several of these enzymes were upregulated by the virus. Roles for acyl-CoA synthetases and elongases during infection were confirmed by using small molecule antagonists. Consistent with a role for these enzymes, mass spectrometry-based fatty acid analysis with ¹³C-labeling revealed that malonyl-CoA is consumed by elongases to produce very long chain fatty acids, generating an approximately 8-fold increase in C26-C34 fatty acid tails in infected cells. The virion envelope was yet further enriched in C26-C34 saturated fatty acids, and elongase inhibitors caused the production of virions with lower levels of these fatty acids and markedly reduced infectivity. These results reveal a dependence of cytomegalovirus on very long chain fatty acid metabolism.

  5. Radon, thoron and their progeny levels in some dwellings of Union Territory Chandigarh, India using SSNTDs

    International Nuclear Information System (INIS)

    Mehta, Vimal; Kumar, Amit; Chauhan, R.P.; Mudahar, G.S.

    2013-01-01

    Indoor air quality is an important issue for protection against adverse health effects caused by the inhalation of pollutants because most individuals spend 90% of their time indoors and that indoor air quality is deteriorated by a large variety of sources. Out of these sources radon is a major pollutant and is an important global problem of radiation hygiene. Radon and its progeny are the major contributors in the radiation dose received by general population of the world. Next to cigarette smoking, the inhalation of radon gas and the products of its radioactive disintegration are considered the most significant cause of lung cancer. Due to the potentially serious public health implications of exposure to high levels of radon, the environmental monitoring of radon, thoron and their progeny in some dwellings of Chandigarh, union territory of India has been carried out. The radon-thoron twin dosimeter cups were used for the study. The aim of the study is the possible health risk assessment in the dwellings under consideration. (author)

  6. Assessment of Inhibition of Ebola Virus Progeny Production by Antiviral Compounds.

    Science.gov (United States)

    Falzarano, Darryl

    2017-01-01

    Assessment of small molecule compounds against filoviruses, such as Ebola virus, has identified numerous compounds that appear to have antiviral activity and should presumably be further investigated in animal efficacy trials. However, despite the many compounds that are purported to have good antiviral activity in in vitro studies, there are few instances where any efficacy has been reported in nonhuman primate models. Many of the high-throughput screening assays use reporter systems that only recapitulate a portion of the virus life cycle, while other assays only assess antiviral activity at relatively early time points. Moreover, many assays do not assess virus progeny production. A more in-depth evaluation of small numbers of test compounds is useful to economize resources and to generate higher quality antiviral hits. Assessing virus progeny production as late as 5 days post-infection allows for the elimination of compounds that have initial antiviral effects that are not sustained or where the virus rapidly develops resistance. While this eliminates many potential lead compounds that may be worthy of further structure-activity relationship (SAR) development, it also quickly excludes compounds that in their current form are unlikely to be effective in animal models. In addition, the inclusion of multiple assays that assess both cell viability and cell cytotoxicity, via different mechanisms, provides a more thorough assessment to exclude compounds that are not direct-acting antivirals.

  7. Diurnal Variations of Equilibrium Factor and Unattached fraction of Radon Progeny in Some Houses and Laboratories

    International Nuclear Information System (INIS)

    Lee, Seung Chan; Kang, Hee Dong; Kim, Chang Kyu; Lee, Dong Myung

    2001-01-01

    The variation characteristics of radon concentration, equilibrium equivalent concentration and equilibrium factor in some house and laboratory buildings have been studied. The variation of equilibrium factor and the unattached fraction of radon progeny with ventilation condition have been also estimated. The averages of radon concentration, equilibrium equivalent concentration and equilibrium factor were 30 Bq m -3 , 19.6 Bq m -3 and 0.65 in seven houses, while 55.0 Bq m -3 , 31.9 Bq m -3 and 0.58 in three laboratory buildings, respectively. The diurnal variation of radon concentration, equilibrium equivalent concentration and equilibrium factor in indoor showed a typical pattern that the radon concentration, equilibrium equivalent concentration and equilibrium factor increased at dawn and morning, while decreased at midday and evening. While the equilibrium factor rate deceased in the indoor environment which was well ventilated, the unattached fraction of radon progeny increased. The equilibrium factor was in proportion to air pressure and humidity of indoor, whereas in inverse proportion to temperature

  8. Stability analysis of oil yield in oil palm (Elaeis guineensis) progenies in different environments.

    Science.gov (United States)

    Rafii, M Y; Jalani, B S; Rajanaidu, N; Kushairi, A; Puteh, A; Latif, M A

    2012-10-04

    We evaluated 38 dura x pisifera (DP) oil palm progenies in four locations in Malaysia for genotype by environment interaction and genotypic stability studies. The DP progenies derived from crosses between pisifera palms of AVROS, Serdang S27B, Serdang 29/36, and Lever Cameroon were chosen to be the males' parent and Deli dura palms designated as females' parent. All the locations differed in terms of soil physical and chemical properties, and the soil types ranged from coastal clay to inland soils. The genotype by environment interaction and stability of the individual genotypes were analyzed for oil yield trait using several stability techniques. A genotype by environment interaction was detected for oil yield and it had a larger variance component than genotypic variance (σ(2)(gl)/σ(2)(g) = 139.7%). Genotype by environment interaction of oil yield was largely explained by a non-linear relationship between genotypic and environmental values. Overall assessment of individual genotypic stability showed that seven genotypes were highly stable and had consistent performance over the environments for the oil yield trait [total individual genotype stability scored more than 10 and mean oil yielded above the average of the environment (genotype means are more than 34.37 kg·palm(-1)·year(-1))]. These genotypes will be useful for oil palm breeding and tissue culture programs for developing high oil yielding planting materials with stable performance.

  9. Characteristics of indoor radon and its progeny in a Japanese dwelling while using air appliances.

    Science.gov (United States)

    Pornnumpa, C; Tokonami, S; Sorimachi, A; Kranrod, C

    2015-11-01

    Characteristics of radon and its progeny were investigated in different air conditions by turning four types of indoor air appliances on and off in a two-story concrete Japanese dwelling. The four appliances were air conditioner, air cleaner, gas heater and cooker hood. The measurements were done using two devices: (1) a Si-based semiconductor detector for continuous measurement of indoor radon concentration and (2) a ZnS(Ag) scintillation counting system for equilibrium-equivalent radon concentration. Throughout the entire experiment, the cooker hood was the most effective in decreasing indoor radon concentration over a long period of time and the less effective was the air conditioner, while the air cleaner and gas heater did not affect the concentration of radon. However, the results measured in each air condition will differ according to the lifestyles and activities of the inhabitants. In this study, indoor radon and its progeny in a Japanese dwelling will be characterised by the different air conditions. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  10. Genetic variability of Cordia alliodora (R. and P.) Oken progenies; Caracterizacion de la variabilidad genetica de progenies de Cordia alliodora (R. and P.) Oken.

    Energy Technology Data Exchange (ETDEWEB)

    Marulanda, Marta Leonor; Lopez, Ana Maria; Uribe, Marcela; Ospina, Carlos Mario

    2011-07-01

    Cordia alliodora is a well-known wood producer tree of tropical areas of Latin America and the Caribbean characterized for producing valuable wood and by its fast growth rate. In Colombia, it is frequent on agro-forestall systems with coffee. This species, like most forest species have biological problems for genetic improvement programs, such as long regeneration periods and high costs for supporting a population in a long term. The molecular assisted markers in plant breeding programs have had a great impact on genetic improvement, due to the fact they minimize their intervals of regeneration, increase the genetic gain by generation and allow the evaluation of the genetic information essential for the species. In this work, 60 genotypes of C. alliodora were characterized, belonging to the provenance and progenies tests established by the program of genetic improvement of Cenicafe. The characterization was carried out through micro satellite markers, after developing a genomic library enriched with micro satellites of the species. Finally, 24 specific micro satellites were evaluated, 20 of which allowed the detection of 28 polymorphic and multiallelic loci. These results provide a guide for orienting the policies of sustainable production and conservation of this valuable species; also, it provides a useful tool for the identification of clones with commercial interest.

  11. Recurrent postoperative sciatica: Evaluation with MR imaging and enhanced CT

    International Nuclear Information System (INIS)

    Duvauferrier, R.; Frocain, L.; Husson, J.L.

    1987-01-01

    The authors prospectively compared MR imaging performed with a surface coil and CT performed with iodinated contrast agent enhancement in 50 patients with recurrent postoperative sciatica. Surgical decision was an objective measure of accuracy. Surgical treatment was selected for 27 patients. All 27 underwent MR imaging. The 15 patients who underwent CT/surgical treatment were included in the 27 indications of SCMR. All predictions based on MR imaging findings were confirmed at surgery. There were 25 recurrent disk herniations, including five with scar tissue, and two disk herniations above or below the level of the diskectomy. In the 12 patients with scar tissue detected on CT there were seven recurrent disk hernitions, four recurrent disk herniations with scar tissue, and one disk herniation below the level of the diskectomy

  12. Analysing spatially extended high-dimensional dynamics by recurrence plots

    Energy Technology Data Exchange (ETDEWEB)

    Marwan, Norbert, E-mail: marwan@pik-potsdam.de [Potsdam Institute for Climate Impact Research, 14412 Potsdam (Germany); Kurths, Jürgen [Potsdam Institute for Climate Impact Research, 14412 Potsdam (Germany); Humboldt Universität zu Berlin, Institut für Physik (Germany); Nizhny Novgorod State University, Department of Control Theory, Nizhny Novgorod (Russian Federation); Foerster, Saskia [GFZ German Research Centre for Geosciences, Section 1.4 Remote Sensing, Telegrafenberg, 14473 Potsdam (Germany)

    2015-05-08

    Recurrence plot based measures of complexity are capable tools for characterizing complex dynamics. In this letter we show the potential of selected recurrence plot measures for the investigation of even high-dimensional dynamics. We apply this method on spatially extended chaos, such as derived from the Lorenz96 model and show that the recurrence plot based measures can qualitatively characterize typical dynamical properties such as chaotic or periodic dynamics. Moreover, we demonstrate its power by analysing satellite image time series of vegetation cover with contrasting dynamics as a spatially extended and potentially high-dimensional example from the real world. - Highlights: • We use recurrence plots for analysing partially extended dynamics. • We investigate the high-dimensional chaos of the Lorenz96 model. • The approach distinguishes different spatio-temporal dynamics. • We use the method for studying vegetation cover time series.

  13. Recurrent vulvovaginal candidiasis.

    Science.gov (United States)

    Blostein, Freida; Levin-Sparenberg, Elizabeth; Wagner, Julian; Foxman, Betsy

    2017-09-01

    Recurrent vulvovaginal candidiasis (RVVC), multiple episodes of vulvovaginal candidiasis (VVC; vaginal yeast infection) within a 12-month period, adversely affects quality of life, mental health, and sexual activity. Diagnosis is not straightforward, as VVC is defined by the combination of often nonspecific vaginal symptoms and the presence of yeast-which is a common vaginal commensal. Estimating the incidence and prevalence is challenging: most VVC is diagnosed and treated empirically, the availability for purchase of effective therapies over the counter enables self-diagnosis and treatment, and the duration of the relatively benign VVC symptoms is short, introducing errors into any estimates relying on medical records or patient recall. We evaluate current estimates of VVC and RVVC and provide new prevalence estimates using data from a 2011 seven-country (n = 7345) internet panel survey on VVC conducted by Ipsos Health (https://www.ipsos.com/en). We also evaluate information on VVC-associated visits using the National Ambulatory Medical Care Survey. The estimated probability of VVC by age 50 varied widely by country (from 23% to 49%, mean 39%), as did the estimated probability of RVVC after VVC (from 14% to 28%, mean 23%). However estimated, the probability of RVVC was high suggesting RVVC is a common condition. Copyright © 2017 Elsevier Inc. All rights reserved.

  14. Recurrent Respiratory Papillomatosis or Laryngeal Papillomatosis

    Science.gov (United States)

    ... Home » Health Info » Voice, Speech, and Language Recurrent Respiratory Papillomatosis or Laryngeal Papillomatosis On this page: What ... find additional information about RRP? What is recurrent respiratory papillomatosis? Recurrent respiratory papillomatosis (RRP) is a disease ...

  15. Single Low-Dose Ionizing Radiation Induces Genotoxicity in Adult Zebrafish and its Non-Irradiated Progeny.

    Science.gov (United States)

    Lemos, J; Neuparth, T; Trigo, M; Costa, P; Vieira, D; Cunha, L; Ponte, F; Costa, P S; Metello, L F; Carvalho, A P

    2017-02-01

    This study investigated to what extent a single exposure to low doses of ionizing radiation can induce genotoxic damage in irradiated adult zebrafish (Danio rerio) and its non-irradiated F1 progeny. Four groups of adult zebrafish were irradiated with a single dose of X-rays at 0 (control), 100, 500 and 1000 mGy, respectively, and couples of each group were allowed to reproduce following irradiation. Blood of parental fish and whole-body offspring were analysed by the comet assay for detection of DNA damage. The level of DNA damage in irradiated parental fish increased in a radiation dose-dependent manner at day 1 post-irradiation, but returned to the control level thereafter. The level of DNA damage in the progeny was directly correlated with the parental irradiation dose. Results highlight the genotoxic risk of a single exposure to low-dose ionizing radiation in irradiated individuals and also in its non-irradiated progeny.

  16. Recurrent population improvement of rice breeding facilitated with male sterility

    International Nuclear Information System (INIS)

    Fujimaki, Hiroshi

    1982-01-01

    A new rice breeding system has been developed, making use of genic male sterility to utilize diverse breeding materials and to promote genetic recombination. In this system, recurrent selection technique and introgressive hybridization were used to increase the frequencies of producing desired genotypes and to improve the population in succession. To promote genetic recombination by the recurrent selection technique, intermating within the population is necessary, and to introduce useful germ plasms by the introgressive hybridization, back crossing with new genetic material is necessary. These can be done efficiently by using the recessive alleles for male sterility, and the representative models for thisF type of breeding were presented. (Kaihara, S.)

  17. REPRODUCTIVE SYSTEM AND POLLEN FLOW IN PROGENIES OF Qualea grandiflora Mart., A TYPICAL SPECIES OF THE BRAZILIAN CERRADO

    Directory of Open Access Journals (Sweden)

    Lia Maris Orth Ritter Antiqueira

    2015-04-01

    Full Text Available This study analyzed the reproductive system and the pollen dispersion pattern of Qualea grandiflora progenies. This is a typical species from the Brazilian Cerrado about which there are not too many studies from the genetics point of view. The study was conducted in an area of 2.2 hectares located in the Conservation Unit managed by the Forest Institute of the state of São Paulo, Brazil (Assis State Forest. Total genomic DNA of 300 seeds from 25 plants (12 seeds from each plant was extracted and amplified using specific primers to obtain microsatellite markers. Results showed that selfing is frequent among adults and progenies, and the species reproduces by outcrossing between related and unrelated individuals (0.913. The single-locus outcrossing rate was 0.632, which indicates that mating between unrelated individuals is more frequent than between related plants. The selfing rate was low (0.087, that is, the species is allogamous and self-fertilization is reduced. About 35% of the plants in the progenies were full-sibs, and about 57%, half-sibs. Besides, about 8% of the progenies were selfing siblings. The genetic differentiation coefficient within progenies was 0.139, whereas the fixation rate was about 27%. The estimate of the effective size revealed that the genetic representativeness of descent was lower than expected in random mating progenies: The analyzed samples corresponded to only 13.2 individuals of an ideal panmictic population. In environmental recovery programs, seeds, preferably from different fruits, should be collected from 95 trees to preserve the genetic diversity of the species.

  18. Photodynamic therapy for recurrent respiratory papillomatosis.

    Science.gov (United States)

    Lieder, Anja; Khan, Muhammad K; Lippert, Burkard M

    2014-06-05

    Recurrent respiratory papillomatosis (RRP) is a benign condition of the mucosa of the upper aerodigestive tract. It is characterised by recurrent papillomatous lesions and is associated with human papillomavirus (HPV). Frequent recurrence and rapid papilloma growth are common and in part responsible for the onset of potentially life-threatening symptoms. Most patients afflicted by the condition will require repeated surgical treatments to maintain their airway, and these may result in scarring and voice problems. Photodynamic therapy introduces a light-sensitising agent, which is administered either orally or by injection. This substance (called a photo-sensitiser) is selectively retained in hyperplastic and neoplastic tissue, including papilloma. It is then activated by light of a specific wavelength and may be used as a sole or adjuvant treatment for RRP. To assess the effects of photodynamic therapy in the management of recurrent respiratory papillomatosis (RRP) in children and adults. We searched the Cochrane Ear, Nose and Throat Disorders Group Trials Register; the Cochrane Central Register of Controlled Trials (CENTRAL); PubMed; EMBASE; CINAHL; Web of Science; Cambridge Scientific Abstracts; ICTRP and additional sources for published and unpublished trials. The date of the search was 27 January 2014. Randomised controlled trials utilising photodynamic therapy as sole or adjuvant therapy in participants of any age with proven RRP versus control intervention. Primary outcome measures were symptom improvement (respiratory distress/dyspnoea and voice quality), quality of life improvement and recurrence-free interval. Secondary outcomes included reduction in the frequency of surgical intervention, reduction in disease volume and adverse effects of treatment.   We used the standard methodological procedures expected by The Cochrane Collaboration. Meta-analysis was not possible and results are presented descriptively. We included one trial with a total of 23

  19. No. 250-Recurrent Urinary Tract Infection.

    Science.gov (United States)

    Epp, Annette; Larochelle, Annick

    2017-10-01

    To provide an update of the definition, epidemiology, clinical presentation, investigation, treatment, and prevention of recurrent urinary tract infections in women. Continuous antibiotic prophylaxis, post-coital antibiotic prophylaxis, and acute self-treatment are all efficient alternatives to prevent recurrent urinary tract infection. Vaginal estrogen and cranberry juice can also be effective prophylaxis alternatives. A search of PubMed and The Cochrane Library for articles published in English identified the most relevant literature. Results were restricted to systematic reviews, randomized control trials/controlled clinical trials, and observational studies. There were no date restrictions. This update is the consensus of the Sub-Committee on Urogynaecology of the Society of Obstetricians and Gynaecologists of Canada. Recommendations were made according to the guidelines developed by the Canadian Task Force on Preventive Health Care (Table 1). Recurrent urinary tract infections need careful investigation and can be efficiently treated and prevented. Different prophylaxis options can be selected according to each patient's characteristics. Copyright © 2017. Published by Elsevier Inc.

  20. Mondini dysplasia with recurrent meningitis.

    Science.gov (United States)

    Lu, M Y; Lee, P I; Lee, C Y; Hsu, C J

    1996-01-01

    Mondini dysplasia is a congenital malformation of the inner ear, commonly associated with hearing impairment, cerebrospinal fluid otorrhea/rhinorrhea and recurrent meningitis. Two such cases are described, with hearing impairment, cerebrospinal fluid rhinorrhea, and several episodes of meningitis. Diagnosis was confirmed by high-resolution computed tomography. After surgical correction of the malformation, there was no recurrent episode of meningitis at subsequent follow-up. To avoid the suffering and the sequelae of recurrent meningitis, an early diagnosis and prompt surgical intervention are crucial for such patients.

  1. Floral-dip transformation of flax (Linum usitatissimum) to generate transgenic progenies with a high transformation rate.

    Science.gov (United States)

    Bastaki, Nasmah K; Cullis, Christopher A

    2014-12-19

    Agrobacterium-mediated plant transformation via floral-dip is a widely used technique in the field of plant transformation and has been reported to be successful for many plant species. However, flax (Linum usitatissimum) transformation by floral-dip has not been reported. The goal of this protocol is to establish that Agrobacterium and the floral-dip method can be used to generate transgenic flax. We show that this technique is simple, inexpensive, efficient, and more importantly, gives a higher transformation rate than the current available methods of flax transformation. In summary, inflorescences of flax were dipped in a solution of Agrobacterium carrying a binary vector plasmid (T-DNA fragment plus the Linum Insertion Sequence, LIS-1) for 1 - 2 min. The plants were laid flat on their side for 24 hr. Then, plants were maintained under normal growth conditions until the next treatment. The process of dipping was repeated 2 - 3 times, with approximately 10 - 14 day intervals between dipping. The T1 seeds were collected and germinated on soil. After approximately two weeks, treated progenies were tested by direct PCR; 2 - 3 leaves were used per plant plus the appropriate T-DNA primers. Positive transformants were selected and grown to maturity. The transformation rate was unexpectedly high, with 50 - 60% of the seeds from treated plants being positive transformants. This is a higher transformation rate than those reported for Arabidopsis thaliana and other plant species, using floral-dip transformation. It is also the highest, which has been reported so far, for flax transformation using other methods for transformation.

  2. Radiotherapy after subtotally resected or recurrent ganglioglioma

    International Nuclear Information System (INIS)

    Liauw, Stanley L.; Byer, Jennifer E.; Yachnis, Anthony T.; Amdur, Robert J.; Mendenhall, William M.

    2007-01-01

    Purpose: Gangliogliomas can recur after subtotal resection (STR). The role of postoperative radiation therapy (RT) is undefined. Methods and Materials: Eight consecutive patients with low-grade gangliogliomas (n = 7) or anaplastic gangliogliomas (n = 1) were treated with RT between 1987 and 2004. Median age was 17 years. Five patients received adjuvant RT after STR at a median time of 6 weeks after surgery. Three patients received salvage RT at a median time of 17 months after surgery. The median dose of RT was 54 Gy. Control was defined as no progressive disease on serial imaging. Median follow-up was 8.8 years. Results: Of the 7 patients with low-grade gangliogliomas, 3 were controlled after RT and 4 recurred locally. Recurrences were controlled with further surgery (n = 2), chemotherapy (n 1), or re-irradiation (n = 1) (median follow-up, 9 years after salvage therapy). Patients who received adjuvant RT after STR of their low-grade gangliogliomas had an overall local control rate of 75%. All 3 patients who were treated with salvage RT had recurrences in the treated area alone (n 2) or in the treated area with leptomeningeal spread (n = 1). The patient with an anaplastic ganglioglioma was treated with adjuvant RT, and had recurrence in Radiation field after 4 months, then died 1 month later. Conclusions: Adjuvant RT may be indicated to treat select patients with subtotally resected gangliogliomas. Salvage RT for recurrence is probably less effective for long-term control; however, patients who recur may still be candidates for effective salvage therapies in the absence of malignant transformation

  3. Norway spruce (Picea abies Karst. variability in progeny tests in Bosnia and Herzegovina

    Directory of Open Access Journals (Sweden)

    Cvjetković Branislav

    2017-01-01

    Full Text Available Norway spruce is one of the most important economic species is Bosnia and Herzegovina. It is the species at the edge of its natural range; nevertheless it attains significant growth and yield results. The species is often used for afforestation purposes. In the previous period, 4 progeny tests of Norway spruce were established in Bosnia and Herzegovina. The offspring from 6 natural populations: Han Pijesak 1, Han Pijesak 2, Foča, Potoci, Olovo and Kneževo were build-in the progeny tests. In 2016, the samples of Norway spruce from 2 progeny tests: Srebrenica and Drinić were collected. In total, 360 samples were collected. DNA isolation was done according to Dumoline et al. (1990. For assessment of genetic differences among populations, co-dominant nSSR microsatellite system had been used. The number of effective alleles ranged from 7.78 in the population Potoci up to 15 in the population Kneževo, the average number of alleles was 13. The observed heterozygosity ranged from 0.61 for the population Han Pijesak 2 up to 0.68 for population Kneževo. The average observed heterozygosity was 0.65. Fixation index was in the range from -0.073 in the population Potoci, to 0.030 for the population Han Pijesak 2. The average value of Wright fixation index is -0.007. The average fixation index indicates the existence of a very small number of homozygotes. Concerning the variability among populations it has been concluded that the total level of genetic differentiation among populations was very low (FST= 0.026. The result of Nei’s genetic distance shows that the populations Olovo and Potoci are separated from other populations. The results obtained by genetic markers, in addition with other, morphological and physiological markers will be the basis for the further investigation of Norway spruce adaptability and possibility for the transfer of genetic material in light of climate changes.

  4. Evaluation of room air cleaners for the reduction of exposure and dose to indoor radon progeny

    International Nuclear Information System (INIS)

    Hopke, P.K.; Jensen, B.; Wasiolek, P.

    1994-01-01

    Since the proximate source of dose to the cells of the bronchial epithelium is the deposited radon progeny, the exposure and resulting dose could be reduced if the radon decay products were effectively removed from the indoor atmosphere. Thus, room air cleaners could be effective in reducing the risks associated with indoor radon. However, because of the short half-life of 218 Po, it grows back quickly and in the altered aerosol conditions that are produced by the presence of an air cleaner, the exposure/dose conditions as well as the magnitude of the dose can be substantially changed. To examine the nature of the exposure of individuals in normally occupied homes and to determine the effect of various types of room air cleaners on the exposure to and dose from the indoor radon progeny, a series of measurements have been made using an automated graded screen array system. Two extended experiments were performed in homes in Arnprior, Ontario and Parishville, NY, in which filtration systems, a positive ion electrostatic precipitator, and ioniser/fan systems have been tested for their ability to remove both airborne radioactivity and particles. In both experiments, measurements were made over one week periods with an air cleaner operating and the distributions of exposure are compared with measurements of the background conditions when no cleaner is functioning. The doses to both basal and secretory cells of the bronchial epithelium in the first eight generations of the bronchus were calculated using the model developed by James and their distributions are compared among the various exposure conditions. In most cases the presence of the air cleaner reduced the exposure to radon progeny. However, the reductions in dose were generally substantially smaller than the reductions in exposure. In the intercomparisons of the two filtration units and the two identical ioniser/fan systems, the units generally behaved in a similar manner. The results of this substantial set of

  5. Recurrent networks for wave forecasting

    Digital Repository Service at National Institute of Oceanography (India)

    Mandal, S.; Prabaharan, N.

    , merchant vessel routing, nearshore construction, etc. more efficiently and safely. This paper presents an application of the Artificial Neural Network, namely Backpropagation Recurrent Neural Network (BRNN) with rprop update algorithm for wave forecasting...

  6. Opioids and breast cancer recurrence

    DEFF Research Database (Denmark)

    Cronin-Fenton, Deirdre P; Heide-Jørgensen, Uffe; Ahern, Thomas P

    2015-01-01

    BACKGROUND: Opioids may alter immune function, thereby potentially affecting cancer recurrence. The authors investigated the association between postdiagnosis opioid use and breast cancer recurrence. METHODS: Patients with incident, early stage breast cancer who were diagnosed during 1996 through...... 2008 in Denmark were identified from the Danish Breast Cancer Cooperative Group Registry. Opioid prescriptions were ascertained from the Danish National Prescription Registry. Follow-up began on the date of primary surgery for breast cancer and continued until breast cancer recurrence, death......, emigration, 10 years, or July 31, 2013, whichever occurred first. Cox regression models were used to compute hazard ratios and 95% confidence intervals associating breast cancer recurrence with opioid prescription use overall and by opioid type and strength, immunosuppressive effect, chronic use (≥6 months...

  7. Comparison of methods and instruments for 222Rn/220Rn progeny measurement

    International Nuclear Information System (INIS)

    Liu Yanyang; Shang Bing; Wu Yunyun; Zhou Qingzhi

    2012-01-01

    In this paper, comparisons were made among three methods of measurement (grab measurement, continuous measurement and integrating measurement) and also measurement of different instruments for a radon/thoron mixed chamber. Taking the optimized five-segment method as a comparison criterion, for the equilibrium-equivalent concentration of 222 Rn, measured results of Balm and 24 h integrating detectors are 31% and 29% higher than the criterion, the results of Wl x, however, is 20% lower; and for 220 Rn progeny, the results of Fiji-142, Kf-602D, BWLM and 24 h integrating detector are 86%, 18%, 28% and 36% higher than the criterion respectively, except that of WLx, which is 5% lower. For the differences shown, further research is needed. (authors)

  8. Variation of indoor radon progeny concentration and its role in dose assessment

    International Nuclear Information System (INIS)

    Singh, Manmohan; Singh, Kulwant; Singh, Surinder; Papp, Z.

    2008-01-01

    Instantaneous measurements of equilibrium equivalent concentration of radon (EEC Rn ) were taken over a period of 1 year in 2004 in a typical house at Amritsar city, located in the northwest part of India. A method based on absolute beta counting subsequent to grab aerosol sampling was used. During that year, EEC Rn varied between 1.56 Bq m -3 and 22.77 Bq m -3 with average value of 8.76 Bq m -3 . EEC Rn decreased with the transition from winter to summer and vice versa, having a negative correlation with outdoor temperature. The use of mechanical ventilation, under normal living conditions during summer, caused an extra decrease in the concentrations. The variations with temperature and mechanical ventilation are discussed. Some major issues related to the uncertainties in dose calculations caused by the lack of knowledge of equilibrium factor and ignoring the effect of life style on the radon and its progeny concentrations are discussed

  9. Evaluation of the external exposure to Rn-222 progeny in air

    International Nuclear Information System (INIS)

    Ali, E.M.; Taha, T.M.; Gomaa, M.A.; El-Hussein, A.M.; Ahmed, A.A.

    2003-01-01

    The aim of this paper is to evaluate the Rn-222 progeny annual effective dose, skin dose and effective doses to different organs such as Gonad, Lung, Red Marrow, Bone surface, Thyroid, and the Remainder. Dose Coefficients of external exposure to Rn-222 in air was used in mSv s/Bqm -3 to calculate the organ doses. The study was monitored for two places, Nuclear Research Center and Al-Minia University. We have confirmed that the inhalation modes, sleep, sitting, light and heavy exercise influence the activity inhalation rate Bq/hr. It varies from 0.3 to 39.6 Bq/hr., the organ doses of Pb-214 is higher than Bi-214/Po-214 and Po-218 respectively in the case of the organ dose relative to environmental media

  10. Metabolic kinetics and absorbed doses of 137Cs in lactating rats and progeny during suckling

    International Nuclear Information System (INIS)

    Lyaginskaya, A.M.; Osipov, V.A.; Dement'ev, S.I.; Ermalitskij, A.P.

    2000-01-01

    The transfer of 137 Cs with maternal milk to progeny was studied in rats The rats were administered with 25 kBq/g of 137 Cs nitrate (pH = 6) in a single oral dose immediately after delivery. Nonpregnant females served as control. Absorbed doses per activity unit to lactating rats were 23 % lover than to nonlactating ones. Over the suckling period absorbed doses to young rats amounted to about 35 % of the absorbed dose to the nursing female. For nonlactating females the internal dose approximately equalled the sum of doses to the nursing female and young rats. Lactating is the effective way for removal of 1 '3 7 Cs from organism of the rats. Content of 1 '3 7 Cs in lactating rat becomes on 42.9 % lower than in organism of nonlactating rat during period of lactating (near 20 days) [ru

  11. Measurement of radon progeny concentrations in air by alpha-particle spectrometey

    International Nuclear Information System (INIS)

    Kerr, G.D.

    1975-07-01

    A technique is presented for measuring air concentrations of the short-lived progeny of radon-222 by the use of alpha spectrometry. In this technique, the concentration of RaA, RaB, and RaC are calculated from one integral count of the RaA and two integral counts of the RaC' alpha-particle activity collected on a filter with an air sampling device. The influence of air sampling and counting intervals of time on the accuracy of the calculated concentrations is discussed in the report. A computer program is presented for use with this technique. It is written in the BASIC language. The program will calculate the air concentrations of RaA, RaB, and RaC, and will estimate the accuracy in these calculated concentrations. (U.S.)

  12. Effects of oral, subchronic cadmium administration on fertility prenatal and postnatal progeny development in rats

    Energy Technology Data Exchange (ETDEWEB)

    Baranski, B.; Stetkiewicz, I.; Sitarek, K.; Szymczak, W.

    1983-12-01

    Cadmium chloride was administered by gavage to female rats 5 days a week for 5 weeks, then during mating and gestation periods at doses of 0.04, 0.4, and 4 mg Cd/kg/day. Treatment with cadmium neither affected the survival and fertility of females, nor produced overt fetotoxic effects. Fetal cadmium concentration was not related to the level of exposure. Litter size, body weight gain and viability of offspring during 2 months after parturition were similar in all groups. The exploratory locomotor activity of 2-month-old males and females born to rats given 0.4 and 4 mg Cd/kg/day was significantly reduced. The progeny of cadmium-treated females showed decreased performance in the rotarod test. In general, the degree of behavioral impairment was dose-related.

  13. Field applications of a radon barrier to reduce indoor airborne progeny

    International Nuclear Information System (INIS)

    Culot, M.V.J.; Olson, H.G.; Schiager, K.J.

    1978-01-01

    The use of uranium mill tailings in the foundations of dwellings has resulted in indoor radon progeny concentrations and gamma exposures in excess of levels presently allowed for the general public. An account is given of the applications of an epoxy coating on the indoor faces of the concrete foundations of three buildings in Grand Junction, Colorado. Epoxy barriers were shown to be effective for preventing radon influx into structures. Gamma exposure rates must be analyzed to ensure that buildup behind the barrier will not introduce an unacceptable gamma exposure level. The use of a sealant is especially economical in situations where structural integrity may be jeopardized by physical removal of uranium mill tailings. (author)

  14. Effects of aerosol polydispersity on theoretical calculations of unattached fractions of radon progeny

    International Nuclear Information System (INIS)

    Bandi, F.; Khan, A.; Phillips, C.R.

    1987-01-01

    Theoretical calculations of unattached fractions of radon progeny require prediction of an attachment coefficient. Average attachment coefficients for aerosols of various count median diameters, CMD, and geometric standard deviations, σ/sub g/, are calculated using four different theories. These theories are: (1) the kinetic theory, (2) the diffusion theory, (3) the hybrid theory and (4) the kinetic-diffusion theory. Comparisons of the various calculated attachment coefficients are made and the implications of using either the kinetic or the diffusion theory to calculate unattached fractions for aerosols of various CMD and σg are discussed. Significant errors may arise in use of either the kinetic theory or the diffusion theory. Large and unacceptable errors arise in calculating unattached fractions of a polydisperse aerosol by characterizing the aerosol as monodisperse. Unattached fractions of RaA are calculated for two mine aerosols and a room aerosol

  15. Enhancement of exposure to radon progeny as a consequence of passive smoking

    International Nuclear Information System (INIS)

    Moghissi, A.A.; Seiler, M.C.

    1989-01-01

    Among indoor air pollutants, radon and tobacco smoke take dominant positions. Because radon decay products have a relatively short residence time in air, the extent of the equilibrium between radon and its daughter products is linearly proportional to the carcinogenic risk, at least at low exposure levels. The relevant factor is the equilibrium factor F. This paper discusses the enhancement of radon exposure as a result of the presence of particulate matter originating from tobacco smoke. The presence of tobacco smoke provides a mechanism for radon progeny to be attached to inhalable particles and to remain in indoor air for a prolonged time. The results of our study indicate a significant increase in F as a consequence of passive smoking. These modeling efforts are consistent with the experimental data reported previously

  16. Microclimatic effects on outdoor radon and its progeny in a long-term study

    International Nuclear Information System (INIS)

    Schuetz, M.; Keller, G.; Kappel, R.J.A.

    1994-01-01

    The dose due to the long term radon exposure is estimated from the radon concentration and from an equilibrium factor that in the literature is reported with a wide uncertainty. Therefore the radon equilibrium factor outdoors and its dependence on climatic effects should be investigated in a long-term study. Both the outdoor concentrations of radon and of its progeny near Ellweiler/Hunsrueck were measured continuously during 12 months and the resulting equilibrium factors were determined. Simultaneously to the every 2 hour's radon data many meterological parameters as temperature and relative to humidity of the air, barometric pressure and duration and amount of rainfall were recorded. At a height of 6 meters above ground and in 10 minute intervals the local wind direction and velocity were registered. By that a set of more than 3000 single measurements of the equilibrium factor and of the corresponding weather conditions was collected

  17. Underground measurements of aerosol in radon and thoron progeny activity distributions

    International Nuclear Information System (INIS)

    Khan, A.; Bandi, F.; Phillips, C.R.; Duport, P.

    1990-01-01

    Aerosol and activity distributions of 218 Polonium, 214 Lead, 214 Bismuth, and 212 Lead were determined in two different underground mining environments by means of an optimized time-delay counting scheme and diffusion batteries. In one environment, diesel equipment was operating; and in the other, electrically powered equipment. The two environments differed significantly in total aerosol concentration. In the diesel environment, in particular, aerosol concentrations were unsteady, and fluctuated with vehicular traffic and mining activities. As measured by radon progeny disequilibrium, the age of the air ranged from about 25 to 60 minutes. Thoron working levels were of the same order as radon working levels. In this paper, comparisons are made between the aerosol and activity size distributions in both the diesel and electric mine

  18. STUDY OF RADIATION EXPOSURE DUE TO RADON, THORON AND THEIR PROGENY IN THE INDOOR ENVIRONMENT OF RAJPUR REGION OF UTTARAKHAND HIMALAYA.

    Science.gov (United States)

    Kandari, Tushar; Aswal, Sunita; Prasad, Mukesh; Pant, Preeti; Bourai, A A; Ramola, R C

    2016-10-01

    In the present study, the measurements of indoor radon, thoron and their progeny concentrations have been carried out in the Rajpur region of Uttarakhand, Himalaya, India by using LR-115 solid-state nuclear track detector-based time-integrated techniques. The gas concentrations have been measured by single-entry pin-hole dosemeter technique, while for the progeny concentrations, deposition-based Direct Thoron and Radon Progeny Sensor technique has been used. The radiation doses due to the inhalation of radon, thoron and progeny have also been determined by using obtained concentrations of radon, thoron and their progeny in the study area. The average radon concentration varies from 75 to 123 Bq m -3 with an overall average of 89 Bq m -3 The average thoron concentration varies from 29 to 55 Bq m -3 with an overall average of 38 Bq m -3 The total annual effective dose received due to radon, thoron and their progeny varies from 2.4 to 4.1 mSv y -1 with an average of 2.9 mSv y -1 While the average equilibrium factor for radon and its progeny was found to be 0.39, for thoron and its progeny, it was 0.06. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  19. Study on calculation models and distribution rules of the radon concentration and its progenies concentration in blind roadway with forced-exhaust ventilation

    International Nuclear Information System (INIS)

    Ye Yongjun; Wang Liheng; Zhou Xinghuo; Li Xiangyang; Zhong Yongming; Wang Shuyun; Ding Dexin

    2014-01-01

    The forced-exhaust ventilation is an important way to control the concentration of radon and its progenies in long-distance blind driving roadway. It is of great significance for guiding the design of ventilation and radiation protection to study distribution characteristics of the concentration of radon and its progenies in the wind of roadway adopting the forced-exhaust ventilation. Therefore, according to the decay relationship of radon and its progenies, a simplified mathematical calculation model was built, which relates to the radon activity concentration and the potential alpha concentration of radon progenies. The paper also analyzed the sources of radon and its progenies in the limited space of the blind roadway. Then, based on the turbulence mass transfer theory of ventilation air flow, the paper established mathematical calculation models of distribution characteristics of the radon activity concentration and the potential alpha concentration of radon progenies in blind roadway with forced-exhaust ventilation, respectively. Finally, the paper applied the calculation models to a special blind roadway, and discussed the influence of the ventilation air inflow and the radon exhalation rate of rock wall on the distribution of radon concentration and the potential alpha concentration of radon progenies in the roadway. Meanwhile, some protective measurements were put forward to reduce the radiation dose of worker caused by radon and its progenies in the blind roadway. (authors)

  20. Analysis of disconnected diallel mating designs II: results from a third generation progeny test of the New Zealand radiata pine improvement programme.

    Science.gov (United States)

    J.N. King; M.J. Carson; G.R. Johnson

    1998-01-01

    Genetic parameters from a second generation (F2) disconnected diallel progeny test of the New Zealand radiata pine improvement programme are presented. Heritability estimates of growth and yield traits of 0.2 are similar to progeny test results of the previous generation (F1) generation tests. A trend of declining dominance...

  1. Responses of human embryonic stem cells and their differentiated progeny to ionizing radiation

    Energy Technology Data Exchange (ETDEWEB)

    Zou, Ying; Zhang, Ningzhe; Ellerby, Lisa M.; Davalos, Albert R.; Zeng, Xianmin; Campisi, Judith [Buck Institute for Research on Aging, Novato, CA 94945 (United States); Desprez, Pierre-Yves, E-mail: pydesprez@cpmcri.org [Buck Institute for Research on Aging, Novato, CA 94945 (United States); California Pacific Medical Center, Research Institute, San Francisco, CA 94107 (United States)

    2012-09-14

    Highlights: Black-Right-Pointing-Pointer hESCs and their progeny, NSCs and neurons, were exposed to ionizing radiation. Black-Right-Pointing-Pointer Upon irradiation, most hESCs died within 5-7 h. Black-Right-Pointing-Pointer Surviving NSCs underwent senescence and displayed features of astrocytes. Black-Right-Pointing-Pointer Surviving NSCs did not display the secretory phenotype expressed by pure astrocytes. Black-Right-Pointing-Pointer This study is to better understand the stress-responses of hESCs and their progeny. -- Abstract: Human embryonic stem cells (hESCs) hold promise for the treatment of many human pathologies. For example, hESCs and the neuronal stem cells (NSCs) and neurons derived from them have significant potential as transplantation therapies for a variety of neurodegenerative diseases. Two concerns about the use of hESCs and their differentiated derivatives are their ability to function and their ability to resist neoplastic transformation in response to stresses that inevitably arise during their preparation for transplantation. To begin to understand how these cells handle genotoxic stress, we examined the responses of hESCs and derived NSCs and neurons to ionizing radiation (IR). Undifferentiated hESCs were extremely sensitive to IR, with nearly all the cells undergoing cell death within 5-7 h. NSCs and neurons were substantially more resistant to IR, with neurons showing the most resistant. Of interest, NSCs that survived IR underwent cellular senescence and acquired astrocytic characteristics. Unlike IR-treated astrocytes, however, the NSC-derived astrocytic cells that survived IR did not display the typical pro-inflammatory, pro-carcinogenic senescence-associated secretory phenotype. These findings suggest distinct genotoxic stress-responses of hESCs and derived NSC and neuronal populations, and suggest that damaged NSCs, while failing to function, may not cause local inflammation.

  2. Investigation of Differences in Fertility among Progenies from Self-Pollinated Chrysanthemum

    Directory of Open Access Journals (Sweden)

    Fan Wang

    2018-03-01

    Full Text Available Most chrysanthemum cultivars are self-incompatible, so it is very difficult to create pure lines that are important in chrysanthemum breeding and theoretical studies. In our previous study, we obtained a self-compatible chrysanthemum cultivar and its self-pollinated seed set was 56.50%. It was interesting that the seed set of its ten progenies ranged from 0% to 37.23%. Examination of the factors causing the differences in the seed set will lead to an improved understanding of chrysanthemum self-incompatibility, and provide valuable information for creating pure lines. Pollen morphology, pollen germination percentage, pistil receptivity and embryo development were investigated using the in vitro culture method, the paraffin section technique, scanning electron microscopy and transmission electron microscopy. Moreover, RNA sequencing and bioinformatics were applied to analyzing the transcriptomic profiles of mature stigmas and anthers. It was found that the self-pollinated seed set of “Q10-33-1①”,”Q10-33-1③”,”Q10-33-1④” and “Q10-33-1⑩” were 37.23%, 26.77%, 7.97% and 0%, respectively. The differences in fertility among four progenies were mainly attributable to differences in pollen germination percentage and pistil receptivity. Failure of the seed set in “Q10-33-1⑩” was possibly due to self-incompatibility. In the transcriptomic files, 22 potential stigma S genes and 8 potential pollen S genes were found out.

  3. Radon and progeny sourced dose assessment of spa employees in balneological sites

    International Nuclear Information System (INIS)

    Kemal Uzun, Sefa; Demiroez, Isik

    2016-01-01

    This study was conducted in the scope of IAEA project with the name 'Establishing a Systematic Radioactivity Survey and Total Effective Dose Assessment in Natural Balneological Sites' (TUR/9/018), at the Health Physics department of Saraykoey Nuclear Research and Training Center (SANAEM). The aim of this study is estimation of radon and progeny sourced effective dose for the people who are working at the spa facilities by measuring radon activity concentration (RAC) at the ambient air of indoor spa pools and dressing rooms. As it is known, the source of the radon gas is the radium content of the earth crust. Therefore, thermal waters coming from ground may contain dissolved radon and the radon can diffuse water to air. So the ambient air of spa pools can contain serious RAC that depends on a lot of parameters. In this regard, RAC measurements were executed at the 70 spa facilities in Turkey. The measurements were done with both active and passive methods at ambient air of spa pools and dressing rooms. Thus, active measurements were carried out by using the Alphaguard R with diffusion mode during half an hour, and passive measurements were carried out by using the humidity resistive CR-39 radon detectors during 2 months. Results show that RAC values at ambient air of spa pools varies between 13 Bq m -3 and 10 kBq m -3 . Because long-term measurements are more reliable, if it is available, for dose calculations passive radon measurements (with CR-39 detectors) at ambient air of spa pools and dressing rooms were used, otherwise active measurement results were used. With the measurement by the conversion coefficients of ICRP 65 and occupational data of the employees has got from questionnaire forms, effective dose values were calculated. According to the calculations, spa employees are exposed to annual average dose between 0.05 and 29 mSv because of radon and progeny. (authors)

  4. Epigenetic, histopathological and transcriptomic effects following exposure to depleted uranium in adult zebrafish and their progeny

    Energy Technology Data Exchange (ETDEWEB)

    Gombeau, Kewin, E-mail: kewin.gombeau@gmail.com [Institut de Radioprotection et de SÛreté Nucléaire (IRSN), PRP-ENV/SERIS/LECO, Cadarache, Saint-Paul-lez-Durance 13115 (France); Bourdineaud, Jean-Paul, E-mail: jean-paul.bourdineaud@u-bordeaux.fr [Université de Bordeaux, CNRS, UMR 5805, EPOC, 33400 Talence (France); Ravanat, Jean-Luc, E-mail: jean-luc.ravanat@cea.fr [Univ. Grenoble Alpes, INAC-SyMMES, 38000 Grenoble (France); CEA, INAC-SCIB Laboratoire des Lésions des Acides Nucléiques, 38000 Grenoble (France); Armant, Olivier, E-mail: olivier.armant@irsn.fr [Institut de Radioprotection et de SÛreté Nucléaire (IRSN), PRP-ENV/SERIS/LECO, Cadarache, Saint-Paul-lez-Durance 13115 (France); Camilleri, Virginie, E-mail: virginie.camilleri@irsn.fr [Institut de Radioprotection et de SÛreté Nucléaire (IRSN), PRP-ENV/SERIS/LECO, Cadarache, Saint-Paul-lez-Durance 13115 (France); Cavalie, Isabelle, E-mail: isabelle.cavalie@irsn.fr [Institut de Radioprotection et de SÛreté Nucléaire (IRSN), PRP-ENV/SERIS/LECO, Cadarache, Saint-Paul-lez-Durance 13115 (France); Floriani, Magali, E-mail: magali.floriani@irsn.fr [Institut de Radioprotection et de SÛreté Nucléaire (IRSN), PRP-ENV/SERIS/LECO, Cadarache, Saint-Paul-lez-Durance 13115 (France); and others

    2017-03-15

    Highlights: • The parental DU-exposure induced a significant transfer of uranium into eggs. • Du-exposed progeny exhibited a significant 2-fold increased DNA methylation level. • The transcriptomic response was deeply modified in the DU-exposed organisms. • DU-exposed adult and offspring presented significant histopathological injuries. - Abstract: This study investigated the effects of adult zebrafish exposure to a nominal concentration of 20 μg L{sup −1} of depleted uranium (DU) for six days upon DNA methylation, gene expression and the appearance of histopathological damage in their progeny. In the embryos at the 2–8 cell stage, the parental exposure induced significant DU accumulation, with levels seven times higher than those measured in the control embryos, but in larvae 96 h post-fertilisation (hpf), uranium concentration had already returned to a level identical to that of the control larvae. A significant two-fold increase in the global level of DNA methylation was observed in embryos as early as the prim5 (24 hpf) stage and was still maintained at the 96 hpf stage despite the fact that DU had already been depurated at the later stage. RNA sequencing analysis indicated an impact of parental exposure upon the total RNAs transmitted from the mother to eggs, and the up-regulated genes were those associated with post-traductional protein modification and trafficking and cellular signalling pathways, whereas the down-regulated genes concerned the translational process, cell cycle regulation and several cell signalling pathways. Alterations of photoreceptor cells and the axon-axon junctions between photoreceptors were observed in the eyes of adult fish exposed for 10 days to DU. Actin and myosin filament disorganisation was observed in the skeletal muscles of 96 hpf larvae, at a stage when the maternally transmitted DU had already been excreted. These data reveal the extreme sensitivity of zebrafish embryos to DU transmitted through the oocyte by

  5. Assessment of radiological effect of the indoor radon and its progeny

    International Nuclear Information System (INIS)

    Ramachandran, T.V.; Subbaramu, M.C.; Mishra, U.C.

    1988-01-01

    Of all the sources of environmental radiation, radon and its progeny are considered to be responsible for a significant dose to man, especially when they are in enclosed areas like underground mines, caves, cellars, poorly designed and badly ventilated houses. Linear extrapolation from the dose response value of the uranium miners exposed to higher levels of radon and its daughters also suggest that the majority of the lung cancer incidence could be due to radon. Higher indoor radon levels and shift in the disequilibrium of the progeny concentration in dwellings caused by the lower ventilation rate leads to severalfold increase of lung cancer incidence from radon. The large risk which is anticipated calls for further studies in this field and may also lead to the conclusion that the slight, but much feared, burden due to man-made radioactivity could be more than compensated by controlling critical segments of the environmental radioactivity. In this report the study of risk due to breathing of indoor radon is briefly reviewed. Dose equivalent to the exposed tissue of the respiratory tract of the people living in dwellings are evaluated. Like most of the risk assessment of low level radiation, the effort to quantify the effect of radon in terms of death rate dose due to lung cancer attributable to radon levels indoors, has to rely on the extrapolation from the effects of the higher exposure rate. In situations where soil or building materials contain elevated radium levels, living in energy efficient houses may be as dangerous as heavy smoking. (author). 8 tabs., 5 figs., 41 refs

  6. Responses of human embryonic stem cells and their differentiated progeny to ionizing radiation

    International Nuclear Information System (INIS)

    Zou, Ying; Zhang, Ningzhe; Ellerby, Lisa M.; Davalos, Albert R.; Zeng, Xianmin; Campisi, Judith; Desprez, Pierre-Yves

    2012-01-01

    Highlights: ► hESCs and their progeny, NSCs and neurons, were exposed to ionizing radiation. ► Upon irradiation, most hESCs died within 5–7 h. ► Surviving NSCs underwent senescence and displayed features of astrocytes. ► Surviving NSCs did not display the secretory phenotype expressed by pure astrocytes. ► This study is to better understand the stress-responses of hESCs and their progeny. -- Abstract: Human embryonic stem cells (hESCs) hold promise for the treatment of many human pathologies. For example, hESCs and the neuronal stem cells (NSCs) and neurons derived from them have significant potential as transplantation therapies for a variety of neurodegenerative diseases. Two concerns about the use of hESCs and their differentiated derivatives are their ability to function and their ability to resist neoplastic transformation in response to stresses that inevitably arise during their preparation for transplantation. To begin to understand how these cells handle genotoxic stress, we examined the responses of hESCs and derived NSCs and neurons to ionizing radiation (IR). Undifferentiated hESCs were extremely sensitive to IR, with nearly all the cells undergoing cell death within 5–7 h. NSCs and neurons were substantially more resistant to IR, with neurons showing the most resistant. Of interest, NSCs that survived IR underwent cellular senescence and acquired astrocytic characteristics. Unlike IR-treated astrocytes, however, the NSC-derived astrocytic cells that survived IR did not display the typical pro-inflammatory, pro-carcinogenic senescence-associated secretory phenotype. These findings suggest distinct genotoxic stress-responses of hESCs and derived NSC and neuronal populations, and suggest that damaged NSCs, while failing to function, may not cause local inflammation.

  7. Epigenetic, histopathological and transcriptomic effects following exposure to depleted uranium in adult zebrafish and their progeny

    International Nuclear Information System (INIS)

    Gombeau, Kewin; Bourdineaud, Jean-Paul; Ravanat, Jean-Luc; Armant, Olivier; Camilleri, Virginie; Cavalie, Isabelle; Floriani, Magali

    2017-01-01

    Highlights: • The parental DU-exposure induced a significant transfer of uranium into eggs. • Du-exposed progeny exhibited a significant 2-fold increased DNA methylation level. • The transcriptomic response was deeply modified in the DU-exposed organisms. • DU-exposed adult and offspring presented significant histopathological injuries. - Abstract: This study investigated the effects of adult zebrafish exposure to a nominal concentration of 20 μg L −1 of depleted uranium (DU) for six days upon DNA methylation, gene expression and the appearance of histopathological damage in their progeny. In the embryos at the 2–8 cell stage, the parental exposure induced significant DU accumulation, with levels seven times higher than those measured in the control embryos, but in larvae 96 h post-fertilisation (hpf), uranium concentration had already returned to a level identical to that of the control larvae. A significant two-fold increase in the global level of DNA methylation was observed in embryos as early as the prim5 (24 hpf) stage and was still maintained at the 96 hpf stage despite the fact that DU had already been depurated at the later stage. RNA sequencing analysis indicated an impact of parental exposure upon the total RNAs transmitted from the mother to eggs, and the up-regulated genes were those associated with post-traductional protein modification and trafficking and cellular signalling pathways, whereas the down-regulated genes concerned the translational process, cell cycle regulation and several cell signalling pathways. Alterations of photoreceptor cells and the axon-axon junctions between photoreceptors were observed in the eyes of adult fish exposed for 10 days to DU. Actin and myosin filament disorganisation was observed in the skeletal muscles of 96 hpf larvae, at a stage when the maternally transmitted DU had already been excreted. These data reveal the extreme sensitivity of zebrafish embryos to DU transmitted through the oocyte by exposed

  8. Recurrent inspection of tubes

    International Nuclear Information System (INIS)

    Andersson, S.

    1984-01-01

    Recommendations concerning the selection of areas for the inspection of tubes have been outlined. The aim is to focus the control on the regions which are important for the safety and where damage is supposed to take place. The number of zones will depend on the risk factors as judged by experts. The localizing will be based upon probable damaging mechanisms. A certain number of areas should be chosen at random. (G.B.)

  9. Recurrence of superficial vein thrombosis in patients with varicose veins.

    Science.gov (United States)

    Karathanos, Christos; Spanos, Konstantinos; Saleptsis, Vassileios; Tsezou, Aspasia; Kyriakou, Despina; Giannoukas, Athanasios D

    2016-08-01

    To investigate which factors other than history of superficial vein thrombosis (SVT) are associated with recurrent spontaneous SVT episodes in patients with varicose veins (VVs). Patients with a history of spontaneous SVT and VVs were followed up for a mean period of 55 months. Demographics, comorbidities, and thrombophilia screening test were analyzed. Patients were grouped according to the clinical-etiology-anatomy-pathophysiology classification. A multiple logistic regression analysis with the forward likelihood ratio method was undertaken. Thirteen patients out of 97 had a recurrence SVT episode during the follow-up period. All those patients were identified to have a thrombophilia defect. Protein C and S, antithrombin, and plasminogen deficiencies were more frequently present in patients without recurrence. Gene mutations were present in 38% in the nonrecurrence group and 77% in the recurrence group. After logistic regression analysis, patients with dislipidemia and mutation in prothrombin G20210A (FII) had an increased risk for recurrence by 5.4-fold and 4.6-fold, respectively. No deep vein thrombosis or pulmonary embolism occurred. Dislipidemia and gene mutations of F II are associated with SVT recurrence in patients with VVs. A selection of patients may benefit from anticoagulation in the short term and from VVs intervention in the long term. © The Author(s) 2015.

  10. Kin Selection - Mutation Balance

    DEFF Research Database (Denmark)

    Dyken, J. David Van; Linksvayer, Timothy Arnold; Wade, Michael J.

    2011-01-01

    selection-mutation balance, which provides an evolutionary null hypothesis for the statics and dynamics of cheating. When social interactions have linear fitness effects and Hamilton´s rule is satisfied, selection is never strong enough to eliminate recurrent cheater mutants from a population, but cheater...

  11. Assessment of glucose homeostasis in crossbred steer progeny sired by Brahman bulls that experienced prenatal transportation stress

    Science.gov (United States)

    The objective of this experiment was to assess glucose homeostasis of crossbred male progeny whose Brahman sires experienced prenatal transportation stress (PS) in utero. Sixteen steers (PNS group) sired by 3 PS bulls gestating dams were transported for 2 h at 60, 80, 100, 120, and 140 ± 5 d of gest...

  12. No significant level of inheritable interchromosomal aberrations in the progeny of bystander primary human fibroblasts after alpha particle irradiation

    Science.gov (United States)

    Hu, Burong; Zhu, Jiayun; Zhou, Hongning; Hei, Tom K.

    2013-02-01

    A major concern for bystander effects is the probability that normal healthy cells adjacent to the irradiated cells become genomically unstable and undergo further carcinogenesis after therapeutic irradiation or space mission where astronauts are exposed to low dose of heavy ions. Genomic instability is a hallmark of cancer cells. In the present study, two irradiation protocols were performed in order to ensure pure populations of bystander cells and the genomic instability in their progeny were investigated. After irradiation, chromosomal aberrations of cells were analyzed at designated time points using G2 phase premature chromosome condensation (G2-PCC) coupled with Giemsa staining and with multiplex fluorescent in situ hybridization (mFISH). Our Giemsa staining assay demonstrated that elevated yields of chromatid breaks were induced in the progeny of pure bystander primary fibroblasts up to 20 days after irradiation. mFISH assay showed no significant level of inheritable interchromosomal aberrations were induced in the progeny of the bystander cell groups, while the fractions of gross aberrations (chromatid breaks or chromosomal breaks) significantly increased in some bystander cell groups. These results suggest that genomic instability occurred in the progeny of the irradiation associated bystander normal fibroblasts exclude the inheritable interchromosomal aberration.

  13. Identification of steelhead and resident rainbow trout progeny in the Deschutes River, Oregon, revealed with otolith microchemistry

    Science.gov (United States)

    Zimmerman, C.E.; Reeves, G.H.

    2002-01-01

    Comparisons of strontium:calcium (Sr:Ca) ratios in otolith primordia and freshwater growth regions were used to identify the progeny of steelhead Oncorhynchus mykiss (anadromous rainbow trout) and resident rainbow trout in the Deschutes River, Oregon. We cultured progeny of known adult steelhead and resident rainbow trout to confirm the relationship between Sr:Ca ratios in otolith primordia and the life history of the maternal parent. The mean (??SD) Sr:Ca ratio was significantly higher in the otolith primordia of the progeny of steelhead (0.001461 ?? 0.00029; n = 100) than in those of the progeny of resident rainbow trout (0.000829 ?? 0.000012; n = 100). We used comparisons of Sr:Ca ratios in the primordia and first-summer growth regions of otoliths to determine the maternal origin of unknown O. mykiss juveniles (n = 272) collected from rearing habitats within the main-stem Deschutes River and tributary rearing habitats and thus to ascertain the relative proportion of each life history morph in each rearing habitat. Resident rainbow trout fry dominated the bi-monthly samples collected from main-stem rearing habitats between May and November 1995. Steelhead fry dominated samples collected from below waterfalls on two tributaries in 1996 and 1998.

  14. Family-site interaction in Pinus radiata: implications for progeny testing strategy and regionalised breeding in New Zealand.

    Science.gov (United States)

    G.R. Johnson; R.D. Brudon

    1990-01-01

    A progeny test of 170 open-pollinated families from second-generation plus trees of Pinus radiata was established on four sites in New Zealand in 1981. Two test sites were on volcanic purnice soils in the Central North Island region and two were on phosphate-retentive clay soils in the Northland region.Assessments of volume growth, stem straightness, mal-...

  15. Spread of Hepatitis B Viruses In Vitro Requires Extracellular Progeny and May Be Codetermined by Polarized Egress

    Science.gov (United States)

    Funk, A.; Hohenberg, H.; Mhamdi, M.; Will, H.; Sirma, H.

    2004-01-01

    Viruses can spread by different mechanisms: via intracellular particles through cell junctions to neighboring cells or via secreted virions to adjacent or remote cells. The observation of clusters of hepadnavirus-infected cells both in vivo and in primary hepatocytes neither proves the first mechanism nor excludes the second. In order to test which mechanism, if not both, is used by hepatitis B viruses in order to spread, we used primary duck hepatocytes and duck hepatitis B virus (DHBV) as an infection model. If extracellular progeny virus alone determines spreading, neutralizing antisera or drugs blocking virus binding to hepatocytes should abolish secondary infection. In order to test this, we used DHBV envelope-specific neutralizing antisera, as well as suramin, a known inhibitor of infection. Both reagents strongly reduced hepatocellular attachment of viral particles and almost completely abolished primary infection, whereas an ongoing intracellular infection was not affected as long as no progeny virus was released. In contrast, incubation of infected primary hepatocytes with these reagents during release of progeny virus completely prevented secondary infection. Moreover, the combination of electron and immunofluorescence microscopy analyses revealed the residence of viral particles in cytoplasmic vesicles preferentially located near the basolateral membrane of infected hepatocytes. Taken together, these data strongly suggest that hepatitis B viruses mainly spread by secreted, extracellular progeny and point to polarized egress of viral particles into intercellular compartments, which restricts their diffusion and favors transmission of virus to adjacent cells. PMID:15047813

  16. Progeny Density and Nest Availability Affect Parasitism Risk and Reproduction in a Solitary Bee (Osmia lignaria) (Hymenoptera: Megachilidae).

    Science.gov (United States)

    Farzan, Shahla

    2018-02-08

    Gregarious nesting behavior occurs in a broad diversity of solitary bees and wasps. Despite the prevalence of aggregative nesting, the underlying drivers and fitness consequences of this behavior remain unclear. I investigated the effect of two key characteristics of nesting aggregations (cavity availability and progeny density) on reproduction and brood parasitism rates in the blue orchard bee (Osmia lignaria Say) (Hymenoptera: Megachilidae), a solitary species that nests gregariously and appears to be attracted to nesting conspecifics. To do so, I experimentally manipulated nest cavity availability in a region of northern Utah with naturally occurring populations of O. lignaria. Nest cavity availability had a negative effect on cuckoo bee (Stelis montana Cresson) (Hymenoptera: Megachilidae) parasitism rates, with lower parasitism rates occurring in nest blocks with more available cavities. For both S. montana and the cleptoparasitic blister beetle Tricrania stansburyi Haldeman (Coleoptera: Meloidae), brood parasitism rate was negatively correlated with log-transformed O. lignaria progeny density. Finally, cavity availability had a positive effect on male O. lignaria body weight, with the heaviest male progeny produced in nest blocks with the most cavities. These results suggest that cavity availability and progeny density can have substantial effects on brood parasitism risk and reproduction in this solitary bee species. © The Author(s) 2017. Published by Oxford University Press on behalf of Entomological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  17. Recurrence of anxiety disorders and its predictors

    NARCIS (Netherlands)

    Scholten, Willemijn D.; Batelaan, Neeltje M.; van Balkom, Anton J. L. M.; Penninx, Brenda; Smit, Johannes H.; van Oppen, Patricia

    Background: The chronic course of anxiety disorders and its high burden of disease are partly due to the recurrence of anxiety disorders after remission. However, knowledge about recurrence rates and predictors of recurrence is scarce. This article reports on recurrence rates of anxiety disorders

  18. Recurrence of anxiety disorders and its predictors

    NARCIS (Netherlands)

    Scholten, W.D.; Batelaan, N.M.; van Balkom, A.J.L.M.; Penninx, B.W.J.H.; Smit, J.H.; van Oppen, P.

    2013-01-01

    Background: The chronic course of anxiety disorders and its high burden of disease are partly due to the recurrence of anxiety disorders after remission. However, knowledge about recurrence rates and predictors of recurrence is scarce. This article reports on recurrence rates of anxiety disorders

  19. Recurrent pregnancy loss: current perspectives

    Directory of Open Access Journals (Sweden)

    El Hachem H

    2017-05-01

    Full Text Available Hady El Hachem,1,2 Vincent Crepaux,3 Pascale May-Panloup,4 Philippe Descamps,3 Guillaume Legendre,3 Pierre-Emmanuel Bouet3 1Department of Reproductive Medicine, Ovo Clinic, Montréal, QC, Canada; 2Department of Obstetrics and Gynecology, University of Montreal, Montréal, QC, Canada; 3Department of Obstetrics and Gynecology, Angers University Hopsital, Angers, France; 4Department of Reproductive Biology, Angers University Hospital, Angers, France Abstract: Recurrent pregnancy loss is an important reproductive health issue, affecting 2%–5% of couples. Common established causes include uterine anomalies, antiphospholipid syndrome, hormonal and metabolic disorders, and cytogenetic abnormalities. Other etiologies have been proposed but are still considered controversial, such as chronic endometritis, inherited thrombophilias, luteal phase deficiency, and high sperm DNA fragmentation levels. Over the years, evidence-based treatments such as surgical correction of uterine anomalies or aspirin and heparin for antiphospholipid syndrome have improved the outcomes for couples with recurrent pregnancy loss. However, almost half of the cases remain unexplained and are empirically treated using progesterone supplementation, anticoagulation, and/or immunomodulatory treatments. Regardless of the cause, the long-term prognosis of couples with recurrent pregnancy loss is good, and most eventually achieve a healthy live birth. However, multiple pregnancy losses can have a significant psychological toll on affected couples, and many efforts are being made to improve treatments and decrease the time needed to achieve a successful pregnancy. This article reviews the established and controversial etiologies, and the recommended therapeutic strategies, with a special focus on unexplained recurrent pregnancy losses and the empiric treatments used nowadays. It also discusses the current role of preimplantation genetic testing in the management of recurrent pregnancy

  20. Genetic Gain Increases by Applying the Usefulness Criterion with Improved Variance Prediction in Selection of Crosses.

    Science.gov (United States)

    Lehermeier, Christina; Teyssèdre, Simon; Schön, Chris-Carolin

    2017-12-01

    A crucial step in plant breeding is the selection and combination of parents to form new crosses. Genome-based prediction guides the selection of high-performing parental lines in many crop breeding programs which ensures a high mean performance of progeny. To warrant maximum selection progress, a new cross should also provide a large progeny variance. The usefulness concept as measure of the gain that can be obtained from a specific cross accounts for variation in progeny variance. Here, it is shown that genetic gain can be considerably increased when crosses are selected based on their genomic usefulness criterion compared to selection based on mean genomic estimated breeding values. An efficient and improved method to predict the genetic variance of a cross based on Markov chain Monte Carlo samples of marker effects from a whole-genome regression model is suggested. In simulations representing selection procedures in crop breeding programs, the performance of this novel approach is compared with existing methods, like selection based on mean genomic estimated breeding values and optimal haploid values. In all cases, higher genetic gain was obtained compared with previously suggested methods. When 1% of progenies per cross were selected, the genetic gain based on the estimated usefulness criterion increased by 0.14 genetic standard deviation compared to a selection based on mean genomic estimated breeding values. Analytical derivations of the progeny genotypic variance-covariance matrix based on parental genotypes and genetic map information make simulations of progeny dispensable, and allow fast implementation in large-scale breeding programs. Copyright © 2017 by the Genetics Society of America.

  1. Immunomodulatory therapy in refractory/recurrent ovarian cancer

    Directory of Open Access Journals (Sweden)

    Chao-Yu Chen

    2015-04-01

    Conclusion: IMT alone or add-on to palliative/salvage chemotherapy for refractory/recurrent EOC achieves a substantial disease stabilizing rate without severe toxicity, which might be a potential option in selected patients. The ALC 1 month after IMT could be an early indicator to disease stabilization.

  2. Attached and Unattached Activity Size Distribution of Short-Lived Radon Progeny (214Pb) and Evaluation of Deposition Fraction

    International Nuclear Information System (INIS)

    Mohamed, A.; Ahmed, A.A.; Ali, A.E.; Yuness, M.

    2009-01-01

    Inhalation of 2 '2 2 Rn progeny in the domestic environment contributes the greatest fraction of the natural radiation exposure to the public. Dosimetric models are most often used in the assessment of human lung doses due to inhaled radioactivity because of the difficulty in making direct measurements. These models require information about the parameters of activity size distributions of radon progeny. The current study presents measured data on the attached and unattached activity size distributions of radon progeny in indoor air in El-Minia, Egypt. The attached fraction was collected using a low pressure Berner cascade impactor technique. A screen diffusion battery was used for collecting the unattached fraction. Most of the attached activities for 222 Rn progeny were associated with aerosol particles of the accumulation mode. The mean activity median aerodynamic diameter (AMAD) of this mode for 21 4 P b was determined to be 401 nm with relative mean geometric standard deviation of 2.96. The mean value of specific air activity concentration of 214 Pb associated with that mode was determined to be 4.74 %0.44 Bq m -3 . The relative mean geometric standard deviations of unattached 214 Pb was determined to be 1.21 with the mean activity thermodynamic diameter (AMTD) of 1.2 nm. The mean unattached activity concentration of 214 Pb was found to be 0.44%0.14 Bq m-3. Based on the obtained results of radon progeny size distributions (unattached and attached), the deposition fractions in each airway generation of the human lung were evaluated by using a lung deposition model

  3. Comparison of outdoor activity size distributions of 220 Rn and 222 Rn progeny and their Influences on lung dosimetry distributions

    International Nuclear Information System (INIS)

    Mohamed, A.; El-Hussein, A.; Ahmed, A.

    2005-01-01

    In the case of internally deposited radionuclides, direct measurement of the energy absorbed from ionizing radiation emitted by the decaying radionuclides is rarely, if ever, possible. Therefore, one must rely on dosimetric models to obtain estimates of the spatial and temporal patterns of energy deposition in human lung. T These models always need some information about the parameters of activity size distributions of thoron and radon progeny. In the present work, the attached and unattached activity size distributions of thoron and radon progeny were measured in outdoor air of El-Minia, Egypt. The attached samples were collected using a low pressure Berner cascade impactor technique, while a constructed screen diffusion b attery was used for collecting the unattached samples. Most of the attached activities for 222 Rn and 220 Rn progeny were associated with the aerosol particles of the accumulation mode. The activity size distribution of thoron progeny was found to be shifted to slightly smaller particle size, compared to radon progeny. An analytical method has been developed to compute the local energy deposition of 2l2 Bi alpha particles in a target volume of 1 jam spheres located at different depths in bronchial epithelium. In order to reach the target, alpha particles travel either through tissue alone (near-wall dose) or through air and tissue (far-wall dose). It was found that the contribution of near-wall dose is higher than that of the far wall dose. While the depth-dose distributions for nuclides uniformly distributed within the epithelium are practically constant with

  4. RECURRENT NOVAE IN M31

    Energy Technology Data Exchange (ETDEWEB)

    Shafter, A. W. [Department of Astronomy, San Diego State University, San Diego, CA 92182 (United States); Henze, M. [European Space Astronomy Centre, P.O. Box 78, E-28692 Villanueva de la Cañada, Madrid (Spain); Rector, T. A. [Department of Physics and Astronomy, University of Alaska Anchorage, 3211 Providence Dr., Anchorage, AK 99508 (United States); Schweizer, F. [Carnegie Observatories, 813 Santa Barbara St., Pasadena, CA 91101 (United States); Hornoch, K. [Astronomical Institute, Academy of Sciences, CZ-251 65 Ondřejov (Czech Republic); Orio, M. [Astronomical Observatory of Padova (INAF), I-35122 Padova (Italy); Pietsch, W. [Max Planck Institute for Extraterrestrial Physics, P.O. Box 1312, Giessenbachstr., D-85741, Garching (Germany); Darnley, M. J.; Williams, S. C.; Bode, M. F. [Astrophysics Research Institute, Liverpool John Moores University, Liverpool L3 5RF (United Kingdom); Bryan, J., E-mail: aws@nova.sdsu.edu [McDonald Observatory, Austin, TX 78712 (United States)

    2015-02-01

    The reported positions of 964 suspected nova eruptions in M31 recorded through the end of calendar year 2013 have been compared in order to identify recurrent nova (RN) candidates. To pass the initial screen and qualify as a RN candidate, two or more eruptions were required to be coincident within 0.′1, although this criterion was relaxed to 0.′15 for novae discovered on early photographic patrols. A total of 118 eruptions from 51 potential RN systems satisfied the screening criterion. To determine what fraction of these novae are indeed recurrent, the original plates and published images of the relevant eruptions have been carefully compared. This procedure has resulted in the elimination of 27 of the 51 progenitor candidates (61 eruptions) from further consideration as RNe, with another 8 systems (17 eruptions) deemed unlikely to be recurrent. Of the remaining 16 systems, 12 candidates (32 eruptions) were judged to be RNe, with an additional 4 systems (8 eruptions) being possibly recurrent. It is estimated that ∼4% of the nova eruptions seen in M31 over the past century are associated with RNe. A Monte Carlo analysis shows that the discovery efficiency for RNe may be as low as 10% that for novae in general, suggesting that as many as one in three nova eruptions observed in M31 arise from progenitor systems having recurrence times ≲100 yr. For plausible system parameters, it appears unlikely that RNe can provide a significant channel for the production of Type Ia supernovae.

  5. Breeding common bean populations for traits using selection index

    Directory of Open Access Journals (Sweden)

    Dayane Cristina Lima

    2015-02-01

    Full Text Available A common bean (Phaseolus vulgarisL. cultivar must combine desirable genotypes for several traits in order to be accepted by producers and consumers. This study aimed to evaluate selection efficiency when segregating bean populations for traits, by means of a selection index, in order to obtain superior progenies for traits considered. A total of 16 populations from the F4 and F5generations were evaluated in 2011 and 2012, respectively. The traits evaluated were plant architecture, plant disease, grain type and yield. Using standard scores (Z, the sum of the four traits (∑Z was obtained and, based on this information, the best populations were identified. The evaluation of selection effectiveness was performed on 31 progenies from each population. The 496 progenies plus eight controls were evaluated in the F5:6and F5:7 generations for the same traits in July and November 2012, respectively. The selection, using the index based on the sum of standardized variables (∑Z, was efficient for identifying populations with superior progenies for all the traits considered.

  6. Efficacy of Enrofloxacin in the Treatment of Recurrent Pyoderma in Dogs

    Directory of Open Access Journals (Sweden)

    B. Sudhakara Reddy

    2014-07-01

    Full Text Available Dogs with a history of more than three episodes of skin infections in a period of one year were selected for a study on recurrent pyoderma. Oral enrofloxacin along with appropriate simultaneous medication for the underlying associated conditions were chosen as therapy for recurrent pyoderma in dogs. Response to therapy was excellent in all the cases. Improvement was noticed by 12 to 20 days and 20 to 26 days in recurrent superficial and deep pyoderma respectively. Relapse occurred in one dog by 45 days due to re-introduction of allergic food. Enrofloxacin proved to be an effective, safe and convenient antibiotic for the treatment of recurrent pyoderma in dogs.

  7. Avaliação genética de indivíduos e progênies de cupuaçuzeiro no estado do Pará e estimativas de parâmetros genéticos Genetic evaluation of individuals and progenies of Theobroma grandiflorum in the state of Pará and estimates of genetic parameters

    Directory of Open Access Journals (Sweden)

    Rafael Moysés Alves

    2008-09-01

    genetic gain increases from 75.5% to 88.3%, that is to say, from 17 to almost 19 fruits per plant. This reveals a great potential for the commercial cloning of Theobroma grandiflorum. For the characters VBI and VBF high individual narrow sense heritabilities were verified with values ranging from 30% to 54%. This reveals the excellent potential of the recurrent selection to improve the resistance level. It seems enough to consider in the selection just the number of brooms, without being necessary to consider the weight. The correlation between resistance in the fruit and in the inflorescence was high (0.84 indicating some genetic control common to the two characters. Superior progenies were identified for production of fruits and resistance to the broom simultaneously.

  8. VARIABILIDAD GENÉTICA DEL CRECIMIENTO EN PROGENIES SELECTAS DE Pinus radiata

    Directory of Open Access Journals (Sweden)

    Freddy Mora

    2006-09-01

    Full Text Available Heredabilidad en sentido estricto (h2, correlación genética intra-clase (2IC y componentes de varianza para la altura, diámetro a la altura del pecho (DAP y volumen del fuste, a los siete años de edad después de la plantación, fueron analizados en dos ensayos de progenie de Pinus radiata establecidos en el sur de Chile, en orden a examinar la variabilidad genética del crecimiento en una generación avanzada de la especie. Estos ensayos incluyeron árboles provenientes de propagación vegetativa y generativa. Las heredabilidades fueron estimadas para los árboles originados de semillas, y mostraron los siguientes valores: altura, 0.08-0.13; diámetro a la altura del pecho, 0-0.13; volumen del fuste, 0-0.09. Los valores de la correlación genética intra-clase, estimados para el grupo de árboles originados de propagación vegetativa, fueron moderados a bajos (2IC: altura, 0.1-0.11; diámetro a la altura del pecho, 0.01-0.05; volumen del fuste, 0.03-0.06. No obstante la presencia de heredabilidades y correlaciones moderadas para algunas características y, la variación relativamente limitada entre grupos de árboles reflejan la fuerte selección realizada a las progenies. En general, los árboles provenientes de estacas presentaron una tendencia a la menor variación intra-genotípica, y evidenciaron magnitudes relativas de las varianzas debida al grupo (2G mayores a las varianzas familiares (2F, en cuatro de seis caracteres evaluados, indicando una tendencia a la mayor homogeneidad en el crecimiento, característica común de la propagación vegetativa.

  9. Exposure of workers to radon progeny in the Baradla cave at Aggtelek

    International Nuclear Information System (INIS)

    Dezsoe, Z.

    2004-01-01

    By measuring the radon concentration using active technique in all parts of the cave visited in a tour and furthermore by assessing also the time spent at these locations, it is possible to determine the radon level averaged over a tour. The time averaged radon concentration along the route of the cave investigated has been estimated to 970 Bq/m 3 in summer and 410 Bq/m 3 in winter. We concluded that in 62 % of the year cave climate shows warm season and only in 38 % cold season Rn-levels. On this basis the yearly mean radon concentration averaged over the tour comes to 750 Bq/m3. This figure, however, should not be used to estimate exposure because the number of visitors is substantially higher in summer than in winter, so that the tour guides work much more in summer (about 750 tours) than in winter (about 270 tours). Taking this into account, the yearly mean Rn concentration is to 820 Bq/m 3 . Since the dose is delivered by radon progeny and not radon itself, one has to also assess the equilibrium factor representative in the cave. The data available in the literature show that F is always larger than under normal ambient conditions. Published values are between 0.5 - 0.8. As part of this work, several radon progeny concentration measurements have also been made in the Baradla cave at different locations. The results confirm the occurrence of high F-values in caves. Furthermore, the equilibrium factor is increased by the presence of humans (visitors or cavers). In the Virgin Cave, F = 0.5 - 0.6, which increases steadily to about 0.8 due to the activity of man. In this work, F = 0.8 has been used for the dose assessment. Using the ICRP 65 dosimetry model, exposure was calculated to be 4.04 mJhm 3 , which corresponds to an effective dose of 5.8 mSv. (P.A.)

  10. Selección por conformación de reproductores de tilapia roja Oreochromis sp., mediante prueba de progenie

    Directory of Open Access Journals (Sweden)

    Hermes Pineda S.

    2013-10-01

    Full Text Available Objetivo. Contribuir con la caracterización estadística y genotípica (media, media del error estándar, varianza y heredabilidad de la Longitud Total (LT y Longitud Altura del Lomo (LAL, y plantear una estrategia de selección para mejorar la calidad de la semilla de reproductores de tilapia roja Oreochromis sp. Materiales y métodos. El proyecto se realizó en la Granja Experimental y de Producción Piscícola (PCJIC, a un Km del municipio de San Jerónimo, distante 61 Km al Occidente de Medellín (Antioquia. Se conformaron tres grupos de cruzamientos, cada uno en proporción de 3 hembras por 1 macho así: un cruce Hembras Blancas (HB x Macho Rojo (MR y dos cruces Hembras Blancas (HB x Macho Blanco (MB. Las progenies fueron medidas a los 60 días post eclosión, teniendo en cuenta los supuestos estadísticos. Resultados. El ANOVA mostró que las progenies difieren significativamente (p<0.001 para ambas variables continuas. La LT fue mayor para la progenie del cruzamiento HBxMB sin reversión (8.04±1.04cm y LAL fue mayor para la progenie HBxMR (2.33±0.44cm. La correlación pareada entre las variables fue altamente significativa (r≥0.79, p<0.001. Las heredabilidades fueron 0.59 (LT y 0.64 (LAL. Los porcentajes de manchas en las progenies fueron HBxMR (34% y HBxMB no revertida (66%. Conclusiones. La progenie del Grupo 1 HBxMR tuvo los reproductores para una mejor selección por conformación, por lo que se sugiere aumentar el número de animales con mayor LAL. También, considerar la menor cantidad de manchas oscuras y realizar un manejo de reproductores por grupos independientes para selección masal.

  11. The effect of pollen source vs. flower type on progeny performance and seed predation under contrasting light environments in a cleistogamous herb.

    Science.gov (United States)

    Munguía-Rosas, Miguel A; Campos-Navarrete, María J; Parra-Tabla, Víctor

    2013-01-01

    Dimorphic cleistogamy is a specialized form of mixed mating system where a single plant produces both open, potentially outcrossed chasmogamous (CH) and closed, obligately self-pollinated cleistogamous (CL) flowers. Typically, CH flowers and seeds are bigger and energetically more costly than those of CL. Although the effects of inbreeding and floral dimorphism are critical to understanding the evolution and maintenance of cleistogamy, these effects have been repeatedly confounded. In an attempt to separate these effects, we compared the performance of progeny derived from the two floral morphs while controlling for the source of pollen. That is, flower type and pollen source effects were assessed by comparing the performance of progeny derived from selfed CH vs. CL and outcrossed CH vs. selfed CH flowers, respectively. The experiment was carried out with the herb Ruellia nudiflora under two contrasting light environments. Outcrossed progeny generally performed better than selfed progeny. However, inbreeding depression ranges from low (1%) to moderate (36%), with the greatest value detected under shaded conditions when cumulative fitness was used. Although flower type generally had less of an effect on progeny performance than pollen source did, the progeny derived from selfed CH flowers largely outperformed the progeny from CL flowers, but only under shaded conditions and when cumulative fitness was taken into account. On the other hand, the source of pollen and flower type influenced seed predation, with selfed CH progeny the most heavily attacked by predators. Therefore, the effects of pollen source and flower type are environment-dependant and seed predators may increase the genetic differences between progeny derived from CH and CL flowers. Inbreeding depression alone cannot account for the maintenance of a mixed mating system in R. nudiflora and other unidentified mechanisms must thus be involved.

  12. The effect of pollen source vs. flower type on progeny performance and seed predation under contrasting light environments in a cleistogamous herb.

    Directory of Open Access Journals (Sweden)

    Miguel A Munguía-Rosas

    Full Text Available Dimorphic cleistogamy is a specialized form of mixed mating system where a single plant produces both open, potentially outcrossed chasmogamous (CH and closed, obligately self-pollinated cleistogamous (CL flowers. Typically, CH flowers and seeds are bigger and energetically more costly than those of CL. Although the effects of inbreeding and floral dimorphism are critical to understanding the evolution and maintenance of cleistogamy, these effects have been repeatedly confounded. In an attempt to separate these effects, we compared the performance of progeny derived from the two floral morphs while controlling for the source of pollen. That is, flower type and pollen source effects were assessed by comparing the performance of progeny derived from selfed CH vs. CL and outcrossed CH vs. selfed CH flowers, respectively. The experiment was carried out with the herb Ruellia nudiflora under two contrasting light environments. Outcrossed progeny generally performed better than selfed progeny. However, inbreeding depression ranges from low (1% to moderate (36%, with the greatest value detected under shaded conditions when cumulative fitness was used. Although flower type generally had less of an effect on progeny performance than pollen source did, the progeny derived from selfed CH flowers largely outperformed the progeny from CL flowers, but only under shaded conditions and when cumulative fitness was taken into account. On the other hand, the source of pollen and flower type influenced seed predation, with selfed CH progeny the most heavily attacked by predators. Therefore, the effects of pollen source and flower type are environment-dependant and seed predators may increase the genetic differences between progeny derived from CH and CL flowers. Inbreeding depression alone cannot account for the maintenance of a mixed mating system in R. nudiflora and other unidentified mechanisms must thus be involved.

  13. Effect of Polish and foreign purebred Arabian stallions on conformation traits of their progeny participating in shows in the last decade

    Directory of Open Access Journals (Sweden)

    Rafal Czarnecki

    2014-12-01

    Full Text Available Observations confirm correctness of the statement that the best recommendation for a stallion is his progeny. The aim of this study was indicating purebred Arabian stallions passing on to their progeny best conformation traits, assessed in Polish shows, in the past decade, taking into consideration their origin. The analysis included national and foreign stallions used in Polish breeding of purebred Arabian horses, which are fathers of at least 5 heads of progeny. The authors own research proved that progeny of foreign stallions statistically differed significantly from the progeny sired by Polish stallions within all conformation traits tested in shows. In the studied period, the highest final score (91.37 points and note for the trait type (19.11 points was characteristic of the progeny of QR Marc. The best head was passed on by stallions: QR Marc (19.06 points and WH Justice (18.78 points, born in the United States and owned by the European breeders. In the Top Ten of producers passing on a refined head to their progeny, there was only one Polish stallion bred in the Horse Stud Michalw, Ekstern (18.29 points. Progeny with the most correct body structure was sired by foreign stallions, Eden C (18.13 points and QR Marc (18.13 points, and by the Polish stallion, Zlocien (17.95 points. The highest score for the trait legs was obtained by the progeny of the Qatar stallion Gazal Al Shaqab (16.30 points. However, the title of the father of the best movers got an Israeli stallion, Laheeb (18.91 points.

  14. Measurement of unattached aerosols of {sup 222} Rn progeny by means of an electrostatic deposition method; Medicion de la fraccion no unida a aerosoles de la progenie de {sup 222} Rn mediante un metodo de deposicion electrostatica

    Energy Technology Data Exchange (ETDEWEB)

    Canoba, Analia C; Lopez, Fabio O [Autoridad Regulatoria Nuclear, Buenos Aires (Argentina)

    2001-07-01

    A method for the measurement of unattached radon progeny based on its electrostatic deposition onto wire screens, using only one pump, has been implemented and calibrated. The importance of being able of making use of this method is related with the special radiological significance that has the unattached fraction of the short-lived radon progeny. Because of this, the assesment of exposure could be directly related to dose with far greater accuracy than before.The advantages of this method are its simplicity, even with the tools needed for the sample collection, as well as the measurement instruments used. Also, the suitability of this method is enhanced by the fact that it can effectively be used with a simple measuring procedure such as the Kusnetz method. (author)

  15. Measurement of unattached radon progeny based in electrostatic deposition method; Medicion de la fraccion no unida a aerosoles de la progenie de {sup 222}Rn mediante un metodo de deposicion electrostatica

    Energy Technology Data Exchange (ETDEWEB)

    Canoba, A C; Lopez, F O

    1999-07-01

    A method for the measurement of unattached radon progeny based on its electrostatic deposition onto wire screens, using only one pump, has been implemented and calibrated. The importance of being able of making use of this method is related with the special radiological significance that has the unattached fraction of the short-lived radon progeny. Because of this, the assessment of exposure could be directly related to dose with far greater accuracy than before. The advantages of this method are its simplicity, even with the tools needed for the sample collection, as well as the measurement instruments used. Also, the suitability of this method is enhanced by the fact that it can effectively be used with a simple measuring procedure such as the Kusnetz method. (author)

  16. Recurrence quantification analysis of chimera states

    International Nuclear Information System (INIS)

    Santos, M.S.; Szezech, J.D.; Batista, A.M.; Caldas, I.L.; Viana, R.L.; Lopes, S.R.

    2015-01-01

    Chimera states, characterised by coexistence of coherence and incoherence in coupled dynamical systems, have been found in various physical systems, such as mechanical oscillator networks and Josephson-junction arrays. We used recurrence plots to provide graphical representations of recurrent patterns and identify chimera states. Moreover, we show that recurrence plots can be used as a diagnostic of chimera states and also to identify the chimera collapse. - Highlights: • Chimera states have been found in various physical systems. • Recurrence plots is a graphical method useful to locate recurring patterns. • We used recurrence plots to identify the chimera states. • We show also the recurrence plots can identify the chimera collapse

  17. Recurrence quantification analysis of chimera states

    Energy Technology Data Exchange (ETDEWEB)

    Santos, M.S. [Pós-Graduação em Ciências/Física, Universidade Estadual de Ponta Grossa, 84030-900, Ponta Grossa, PR (Brazil); Szezech, J.D., E-mail: jdanilo@gmail.com [Departamento de Matemática e Estatística, Universidade Estadual de Ponta Grossa, 84030-900, Ponta Grossa, PR (Brazil); Batista, A.M., E-mail: antoniomarcosbatista@gmail.com [Departamento de Matemática e Estatística, Universidade Estadual de Ponta Grossa, 84030-900, Ponta Grossa, PR (Brazil); Caldas, I.L. [Instituto de Física, Universidade de São Paulo, 05315-970, São Paulo, SP (Brazil); Viana, R.L.; Lopes, S.R. [Departamento de Física, Universidade Federal do Paraná, 81531-990, Curitiba, PR (Brazil)

    2015-10-02

    Chimera states, characterised by coexistence of coherence and incoherence in coupled dynamical systems, have been found in various physical systems, such as mechanical oscillator networks and Josephson-junction arrays. We used recurrence plots to provide graphical representations of recurrent patterns and identify chimera states. Moreover, we show that recurrence plots can be used as a diagnostic of chimera states and also to identify the chimera collapse. - Highlights: • Chimera states have been found in various physical systems. • Recurrence plots is a graphical method useful to locate recurring patterns. • We used recurrence plots to identify the chimera states. • We show also the recurrence plots can identify the chimera collapse.

  18. Prediction of Bladder Cancer Recurrences Using Artificial Neural Networks

    Science.gov (United States)

    Zulueta Guerrero, Ekaitz; Garay, Naiara Telleria; Lopez-Guede, Jose Manuel; Vilches, Borja Ayerdi; Iragorri, Eider Egilegor; Castaños, David Lecumberri; de La Hoz Rastrollo, Ana Belén; Peña, Carlos Pertusa

    Even if considerable advances have been made in the field of early diagnosis, there is no simple, cheap and non-invasive method that can be applied to the clinical monitorisation of bladder cancer patients. Moreover, bladder cancer recurrences or the reappearance of the tumour after its surgical resection cannot be predicted in the current clinical setting. In this study, Artificial Neural Networks (ANN) were used to assess how different combinations of classical clinical parameters (stage-grade and age) and two urinary markers (growth factor and pro-inflammatory mediator) could predict post surgical recurrences in bladder cancer patients. Different ANN methods, input parameter combinations and recurrence related output variables were used and the resulting positive and negative prediction rates compared. MultiLayer Perceptron (MLP) was selected as the most predictive model and urinary markers showed the highest sensitivity, predicting correctly 50% of the patients that would recur in a 2 year follow-up period.

  19. Management of glioblastoma after recurrence: A changing paradigm

    International Nuclear Information System (INIS)

    Mallick, S.; Benson, R.; Hakim, A.; Rath, G.K.

    2016-01-01

    Glioblastoma remains the most common primary brain tumor after the age of 40 years. Maximal safe surgery followed by adjuvant chemoradiotherapy has remained the standard treatment for glioblastoma (GBM). But recurrence is an inevitable event in the natural history of GBM with most patients experiencing it after 6–9 months of primary treatment. Recurrent GBM poses great challenge to manage with no well-defined management protocols. The challenge starts from differentiating radiation necrosis from true local progression. A fine balance needs to be maintained on improving survival and assuring a better quality of life. Treatment options are limited and ranges from re-excision, re-irradiation, systemic chemotherapy or a combination of these. Re-excision and re-irradiation must be attempted in selected patients and has been shown to improve survival outcomes. To facilitate the management of GBM recurrences, a treatment algorithm is proposed

  20. Statistical modelling for recurrent events: an application to sports injuries.

    Science.gov (United States)

    Ullah, Shahid; Gabbett, Tim J; Finch, Caroline F

    2014-09-01

    Injuries are often recurrent, with subsequent injuries influenced by previous occurrences and hence correlation between events needs to be taken into account when analysing such data. This paper compares five different survival models (Cox proportional hazards (CoxPH) model and the following generalisations to recurrent event data: Andersen-Gill (A-G), frailty, Wei-Lin-Weissfeld total time (WLW-TT) marginal, Prentice-Williams-Peterson gap time (PWP-GT) conditional models) for the analysis of recurrent injury data. Empirical evaluation and comparison of different models were performed using model selection criteria and goodness-of-fit statistics. Simulation studies assessed the size and power of each model fit. The modelling approach is demonstrated through direct application to Australian National Rugby League recurrent injury data collected over the 2008 playing season. Of the 35 players analysed, 14 (40%) players had more than 1 injury and 47 contact injuries were sustained over 29 matches. The CoxPH model provided the poorest fit to the recurrent sports injury data. The fit was improved with the A-G and frailty models, compared to WLW-TT and PWP-GT models. Despite little difference in model fit between the A-G and frailty models, in the interest of fewer statistical assumptions it is recommended that, where relevant, future studies involving modelling of recurrent sports injury data use the frailty model in preference to the CoxPH model or its other generalisations. The paper provides a rationale for future statistical modelling approaches for recurrent sports injury. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  1. Peer Influence and Addiction Recurrence

    OpenAIRE

    Paul Markdissi

    2009-01-01

    In this paper we highlight the role of peers in the recurrence of addictive behavior. To do so, we use a simple “forward looking” model with procrastination and peers influence. Our results show that while procrastination can explain the decision to postpone rehabilitation, peers influence is essential to explain the cyclical patterns of addiction-rehabilitation-addiction.

  2. Interpretation of Recurrent Neural Networks

    DEFF Research Database (Denmark)

    Pedersen, Morten With; Larsen, Jan

    1997-01-01

    This paper addresses techniques for interpretation and characterization of trained recurrent nets for time series problems. In particular, we focus on assessment of effective memory and suggest an operational definition of memory. Further we discuss the evaluation of learning curves. Various nume...

  3. Relativistic phase space: dimensional recurrences

    International Nuclear Information System (INIS)

    Delbourgo, R; Roberts, M L

    2003-01-01

    We derive recurrence relations between phase space expressions in different dimensions by confining some of the coordinates to tori or spheres of radius R and taking the limit as R→∞. These relations take the form of mass integrals, associated with extraneous momenta (relative to the lower dimension), and produce the result in the higher dimension

  4. Generalized Moshinsky bracket recurrence relations

    International Nuclear Information System (INIS)

    Bevelacqua, J.J.

    1979-01-01

    Recurrence relations for generalized Talmi-Moshinsky brackets are derived. These relations permit the generation of transformation brackets once appropriate starting brackets are determined. The savings in computer time, when compared with generating brackets individually, is at least a factor of 10 for brackets with radial quantum numbers as large as 9 and angular quantum numbers as large as 2. (author)

  5. Recurrent processing during object recognition

    Directory of Open Access Journals (Sweden)

    Randall C. O'Reilly

    2013-04-01

    Full Text Available How does the brain learn to recognize objects visually, and perform this difficult feat robustly in the face of many sources of ambiguity and variability? We present a computational model based on the biology of the relevant visual pathways that learns to reliably recognize 100 different object categories in the face of of naturally-occurring variability in location, rotation, size, and lighting. The model exhibits robustness to highly ambiguous, partially occluded inputs. Both the unified, biologically plausible learning mechanism and the robustness to occlusion derive from the role that recurrent connectivity and recurrent processing mechanisms play in the model. Furthermore, this interaction of recurrent connectivity and learning predicts that high-level visual representations should be shaped by error signals from nearby, associated brain areas over the course of visual learning. Consistent with this prediction, we show how semantic knowledge about object categories changes the nature of their learned visual representations, as well as how this representational shift supports the mapping between perceptual and conceptual knowledge. Altogether, these findings support the potential importance of ongoing recurrent processing throughout the brain's visual system and suggest ways in which object recognition can be understood in terms of interactions within and between processes over time.

  6. Ovarian irradiation in recurrent endometriosis

    International Nuclear Information System (INIS)

    Kochbati, L.; Chaari, N.; Besbes, M.; Maalej, M.; Neji, K.; Ben Amara, F.; Ben Romdhane, N.K.

    2005-01-01

    We describe a case of a young woman with a history of an aplastic anaemia in which pelvic radiotherapy was used successfully in the management of a recurrent and inoperable endometriosis. The use of therapeutic pelvic or ovarian irradiation in endometriosis may be considered, when surgical and medical treatments have been exhausted and have failed. (authors)

  7. Drug therapy for recurrence after chemoradiotherapy

    International Nuclear Information System (INIS)

    Okano, Susumu

    2016-01-01

    Most head and neck cancer patients are advanced stage when first diagnosed and about half of them receive chemoradiotherapy (CRT) because the cancer is unresectable or there is hope of functional preservation. In subsequent treatment for recurrence after CRT, many of them receive chemotherapy with or without reirradiation. There are three situations when chemotherapy is used for recurrence after CRT: 1. Re-chemoradiotherapy (Re-CRT) in the adjuvant setting after salvage surgery 2. Re-CRT for cases who cannot receive salvage surgery. 3. Chemotherapy for cases who cannot receive salvage surgery or Re-CRT. In the first situation, Re-CRT is expected to yield a better outcome, but there is concern about severe adverse events, so special care in selecting patients is required. In the second situation, there are some negative comments about Re-CRT, and so cases must be judged individually. In the third situation, there are some choices of treatment, but EBM is based on past large clinical trials, so the treatment based on a guideline or guidance is recommended. Recently, new drugs have been invented and approved in the world, though their cost is increasing rapidly. It is necessary to provide the best treatment that also takes cost-effectiveness into consideration. (author)

  8. Regional deposition of thoron progeny in models of the human tracheobronchial tree

    International Nuclear Information System (INIS)

    Smith, S.M.; Cheng, Yung-Sung; Yeh, Hsu-Chi.

    1995-01-01

    Models of the human tracheobronchial tree have been used to determine total and regional aerosol deposition of inhaled particles. Particle sizes measured in these studies have all been > 40 nm in diameter. The deposition of aerosols < 40 nm in diameter has not been measured. Particles in the ultrafine aerosol size range include some combustion aerosols and indoor radon progeny. Also, the influence of reduced lung size and airflow rates on particle deposition in young children has not been determined. With their smaller lung size and smaller minute volumes, children may be at increased risk from ultrafine pollutants. In order to accurately determine dose of inhaled aerosols, the effects of particle size, minute volume, and age at exposure must be quantified. The purpose of this study was to determine the deposition efficiency of ultrafine aerosols smaller than 40 nm in diameter in models of the human tracheobronchia tree. This study demonstrates that the deposition efficiency of aerosols in the model of the child's tracheobronchial tree may be slightly higher than in the adult models

  9. VH repertoire in progeny of long term lymphoid-cultured cells used to reconstitute immunodeficient mice

    International Nuclear Information System (INIS)

    Denis, K.A.; Timson, L.K.; Witte, O.N.

    1989-01-01

    VH gene utilization in the progeny of long term lymphoid-cultured cells used for reconstitution of severe combined immunodeficient mice under varying conditions was determined. Hybridomas made from the spleens of these animals were evaluated for clonality and donor origin and a panel of 146 independent hybridomas were subsequently examined for VH expression. Hybridomas derived from the spleens of SCID mice reconstituted with fresh cells, used as a control, utilized VH families in proportion to their numerical representation in the genome. However, hybridomas from the spleens of mice reconstituted with long term cultured cells utilized a predominance of the two VH gene families most proximal to JH, characteristic of cells early in B lymphocyte development. Coinjection of thymocytes with cultured fetal liver cells, to provide good levels of T lymphocytes, did not alter this pattern of VH utilization. Irradiation (3 Gy) of the mice before cultured cell injection, which leads to more complete reconstitution of the B cell compartment, was effective in removing this bias in the VH repertoire. Hybridomas derived from these mice expressed their VH genes more in proportion to family size, characteristic of cells later in B lymphocyte development. In this manner, long term lymphoid-cultured cells can be used to study the transitions that occur in VH repertoire expression which appear to be mediated by either B lymphocyte developmental microenvironment or population size

  10. Regional deposition of thoron progeny in models of the human tracheobronchial tree

    Energy Technology Data Exchange (ETDEWEB)

    Smith, S.M.; Cheng, Yung-Sung; Yeh, Hsu-Chi

    1995-12-01

    Models of the human tracheobronchial tree have been used to determine total and regional aerosol deposition of inhaled particles. Particle sizes measured in these studies have all been > 40 nm in diameter. The deposition of aerosols < 40 nm in diameter has not been measured. Particles in the ultrafine aerosol size range include some combustion aerosols and indoor radon progeny. Also, the influence of reduced lung size and airflow rates on particle deposition in young children has not been determined. With their smaller lung size and smaller minute volumes, children may be at increased risk from ultrafine pollutants. In order to accurately determine dose of inhaled aerosols, the effects of particle size, minute volume, and age at exposure must be quantified. The purpose of this study was to determine the deposition efficiency of ultrafine aerosols smaller than 40 nm in diameter in models of the human tracheobronchia tree. This study demonstrates that the deposition efficiency of aerosols in the model of the child`s tracheobronchial tree may be slightly higher than in the adult models.

  11. Unattached fraction and the size distribution of the radon progeny in indoor air

    International Nuclear Information System (INIS)

    Yamasaki, K.; Shimo, M.

    1992-01-01

    The size-distribution of the aerosol-attached radon progeny and the unattached (cluster) fraction were measured by using a low pressure cascade impactor and a single wire screen in a building of the nuclear facility. The radon concentration at the condition of ventilation 'ON' was about 50 Bq m -3 , but it increased exponentially after ventilation 'OFF' and reached to the saturated concentration of about 600 Bq m -3 . At the condition of low aerosol concentration without additional aerosol, the activity median aerodynamic diameter, the geometric standard deviation and the unattached fraction were, respectively, 0.4 μm, 2.7-2.9 and 0.3-0.5. On the other hand, at the condition of high aerosol concentration with burning a mosquito coil, these were, 0.4 μm, 2.1 and 0.02-0.03. These yield 2.5 times higher radiation dose conversion factors at the low aerosol condition than the high aerosol condition. (author)

  12. Bombyx mori nucleopolyhedrovirus BM5 protein regulates progeny virus production and viral gene expression

    International Nuclear Information System (INIS)

    Kokusho, Ryuhei; Koh, Yoshikazu; Fujimoto, Masaru; Shimada, Toru; Katsuma, Susumu

    2016-01-01

    Bombyx mori nucleopolyhedrovirus (BmNPV) orf5 (Bm5) is a core gene of lepidopteran baculoviruses and encodes the protein with the conserved amino acid residues (DUF3627) in its C-terminus. Here, we found that Bm5 disruption resulted in lower titers of budded viruses and fewer numbers of occlusion bodies (OBs) in B. mori cultured cells and larvae, although viral genome replication was not affected. Bm5 disruption also caused aberrant expression of various viral genes at the very late stage of infection. Immunocytochemical analysis revealed that BM5 localized to the nuclear membrane. We also found that DUF3627 is important for OB production, transcriptional regulation of viral genes, and subcellular localization of BM5. Compared with wild-type BmNPV infection, larval death was delayed when B. mori larvae were infected with Bm5 mutants. These results suggest that BM5 is involved in progeny virus production and regulation of viral gene expression at the very late stage of infection. -- Highlights: •The role of BmNPV BM5 protein was examined in B. mori cultured cells and larvae. •BM5 contributes to efficient production of budded viruses and occlusion bodies. •BM5 regulates viral gene expression at the very late stage of infection. •BM5 dominantly localizes to the nuclear membrane. •Bm5 mutant showed v-cath down-regulation and resulting delay of larval death.

  13. Bombyx mori nucleopolyhedrovirus BM5 protein regulates progeny virus production and viral gene expression

    Energy Technology Data Exchange (ETDEWEB)

    Kokusho, Ryuhei, E-mail: kokusho@ss.ab.a.u-tokyo.ac.jp; Koh, Yoshikazu; Fujimoto, Masaru; Shimada, Toru; Katsuma, Susumu, E-mail: katsuma@ss.ab.a.u-tokyo.ac.jp

    2016-11-15

    Bombyx mori nucleopolyhedrovirus (BmNPV) orf5 (Bm5) is a core gene of lepidopteran baculoviruses and encodes the protein with the conserved amino acid residues (DUF3627) in its C-terminus. Here, we found that Bm5 disruption resulted in lower titers of budded viruses and fewer numbers of occlusion bodies (OBs) in B. mori cultured cells and larvae, although viral genome replication was not affected. Bm5 disruption also caused aberrant expression of various viral genes at the very late stage of infection. Immunocytochemical analysis revealed that BM5 localized to the nuclear membrane. We also found that DUF3627 is important for OB production, transcriptional regulation of viral genes, and subcellular localization of BM5. Compared with wild-type BmNPV infection, larval death was delayed when B. mori larvae were infected with Bm5 mutants. These results suggest that BM5 is involved in progeny virus production and regulation of viral gene expression at the very late stage of infection. -- Highlights: •The role of BmNPV BM5 protein was examined in B. mori cultured cells and larvae. •BM5 contributes to efficient production of budded viruses and occlusion bodies. •BM5 regulates viral gene expression at the very late stage of infection. •BM5 dominantly localizes to the nuclear membrane. •Bm5 mutant showed v-cath down-regulation and resulting delay of larval death.

  14. Occupational exposure to radon progeny: Importance, experience with control, regulatory approaches

    International Nuclear Information System (INIS)

    Kraus, W.; Schwedt, J.

    2002-01-01

    An overview of possible occupational exposures to enhanced natural radiation in Germany is given, based on an analysis of the German Radiological Protection Commission. So far, the most significant exposure source is radon at underground and above ground workplaces. As a result of relevant regulations, in East Germany since the 70's a systematic monitoring of exposures to radon progeny has been introduced step by step in the uranium industry, in conventional ore mining, in show caves and mines, in enterprises for securing mining areas against subsidence, in radon spas and in water works in radon affected areas. Individual exposures have been assessed. The monitoring results for the period 1975-1998 are presented. Successful protection measures leading to a significant reduction of the exposures are discussed. using workplace monitoring results and registered occupancy times. In West Germany no regulations in this area were in force. Nevertheless, voluntary measuring programmes at similar workplaces were carried out. In case of unacceptable exposures successful protection measures were implemented. At present a systematic approach to control occupational exposures to radon is laid down in the European Directive 96/29/Euratom which has to be taken over in the national legislation to come. The expected number of workplaces to be included in the radiation protection system in Germany, the recommendable way of including different workplace types taking into account appropriate reference levels, and possible approaches to a graded system of workplace and individual monitoring are discussed in detail. (author)

  15. Validation of the abbreviated Radon Progeny Integrating Sampling Unit (RPISU) method for Mesa County, Colorado

    International Nuclear Information System (INIS)

    Langner, G.H. Jr.

    1987-06-01

    The US Department of Energy (DOE) Office of Remedial Action and Waste Technology established the Technical Measurements Center at the DOE Grand Junction, Colorado, Projects Office to standardize, calibrate, and compare measurements made in support of DOE remedial action programs. Indoor radon-daughter concentration measurements are made to determine whether a structure is in need of remedial action. The Technical Measurements Center conducted this study to validate an abbreviated Radon Progeny Integrated Sampling Unit (RPISU) method of making indoor radon-daughter measurements to determine whether a structure has a radon-daughter concentration (RDC) below the levels specified in various program standards. The Technical Measurements Center established a criterion against which RDC measurements made using the RPISU sampling method are evaluated to determine if sampling can be terminated or whether further measurements are required. This abbreviated RPISU criterion was tested against 317 actual sets of RPISU data from measurements made over an eight-year period in Mesa County, Colorado. The data from each location were tested against a standard that was assumed to be the same as the actual annual average RDC from that location. At only two locations was the criterion found to fail. Using the abbreviated RPISU method, only 0.6% of locations sampled can be expected to be falsely indicated as having annual average RDC levels below a given standard

  16. Comparison of efficiency of distance measurement methodologies in mango (Mangifera indica) progenies based on physicochemical descriptors.

    Science.gov (United States)

    Alves, E O S; Cerqueira-Silva, C B M; Souza, A M; Santos, C A F; Lima Neto, F P; Corrêa, R X

    2012-03-14

    We investigated seven distance measures in a set of observations of physicochemical variables of mango (Mangifera indica) submitted to multivariate analyses (distance, projection and grouping). To estimate the distance measurements, five mango progeny (total of 25 genotypes) were analyzed, using six fruit physicochemical descriptors (fruit weight, equatorial diameter, longitudinal diameter, total soluble solids in °Brix, total titratable acidity, and pH). The distance measurements were compared by the Spearman correlation test, projection in two-dimensional space and grouping efficiency. The Spearman correlation coefficients between the seven distance measurements were, except for the Mahalanobis' generalized distance (0.41 ≤ rs ≤ 0.63), high and significant (rs ≥ 0.91; P < 0.001). Regardless of the origin of the distance matrix, the unweighted pair group method with arithmetic mean grouping method proved to be the most adequate. The various distance measurements and grouping methods gave different values for distortion (-116.5 ≤ D ≤ 74.5), cophenetic correlation (0.26 ≤ rc ≤ 0.76) and stress (-1.9 ≤ S ≤ 58.9). Choice of distance measurement and analysis methods influence the.

  17. Assessing the deposition of radon progeny from a uranium glass necklace

    International Nuclear Information System (INIS)

    Hanse, M.F.; Moss, G.R.

    2015-01-01

    Could jewellery made from uranium glass beads pose an increased risk to skin cancer? The literature Eatough (Alpha-particle dosimetry for the basal layer of the skin and the radon progeny 218 Po and 214 Po. Phys. Med. Biol. 1997;42:1899-1911.) suggests that the alphas from the short-lived radon daughters, 218 Po and 214 Po, may reach the basal layer of the epidermis, which is believed to be important in the induction of skin cancers. The deposition of the alphas from the 218 Po and 214 Po daughters was investigated using PADC detector material. The expectation would be that no alpha particles would penetrate through the dead skin layer, assuming the average of 70 microns used in radiation protection, but the skin around the collar bone could potentially be thinner than the assumed average. It should be noticed that by inserting a slice of pig skin in between the necklace and the PADC, no great excess of alpha tracks were seen after 1 week of exposure in the freezer. There was, however, a clear signal through the pig skin from beta particles, confirming the potential of a uranium bead necklace posing a health risk. (authors)

  18. Application Of Database Program in selecting Sorghum (Sorghum bicolor L) Mutant Lines

    International Nuclear Information System (INIS)

    H, Soeranto

    2000-01-01

    Computer database software namely MSTAT and paradox have been exercised in the field of mutation breeding especially in the process of selecting plant mutant lines of sorghum. In MSTAT, selecting mutant lines can be done by activating the SELECTION function and then followed by entering mathematical formulas for the selection criterion. Another alternative is by defining the desired selection intensity to the analysis results of subprogram SORT. Including the selected plant mutant lines in BRSERIES program, it will make their progenies be easier to be traced in subsequent generations. In paradox, an application program for selecting mutant lines can be made by combining facilities of Table, form and report. Selecting mutant lines with defined selection criterion can easily be done through filtering data. As a relation database, paradox ensures that the application program for selecting mutant lines and progeny trachings, can be made easier, efficient and interactive

  19. How adaptation shapes spike rate oscillations in recurrent neuronal networks

    Directory of Open Access Journals (Sweden)

    Moritz eAugustin

    2013-02-01

    Full Text Available Neural mass signals from in-vivo recordings often show oscillations with frequencies ranging from <1 Hz to 100 Hz. Fast rhythmic activity in the beta and gamma range can be generated by network based mechanisms such as recurrent synaptic excitation-inhibition loops. Slower oscillations might instead depend on neuronal adaptation currents whose timescales range from tens of milliseconds to seconds. Here we investigate how the dynamics of such adaptation currents contribute to spike rate oscillations and resonance properties in recurrent networks of excitatory and inhibitory neurons. Based on a network of sparsely coupled spiking model neurons with two types of adaptation current and conductance based synapses with heterogeneous strengths and delays we use a mean-field approach to analyze oscillatory network activity. For constant external input, we find that spike-triggered adaptation currents provide a mechanism to generate slow oscillations over a wide range of adaptation timescales as long as recurrent synaptic excitation is sufficiently strong. Faster rhythms occur when recurrent inhibition is slower than excitation and oscillation frequency increases with the strength of inhibition. Adaptation facilitates such network based oscillations for fast synaptic inhibition and leads to decreased frequencies. For oscillatory external input, adaptation currents amplify a narrow band of frequencies and cause phase advances for low frequencies in addition to phase delays at higher frequencies. Our results therefore identify the different key roles of neuronal adaptation dynamics for rhythmogenesis and selective signal propagation in recurrent networks.

  20. Recurrent uncomplicated urinary tract infections in women: a review.

    Science.gov (United States)

    Nosseir, Sandy B; Lind, Lawrence R; Winkler, Harvey A

    2012-03-01

    Recurrent urinary tract infections most often present with symptoms of irritative voiding. In most cases, they are caused by reinfection with a previously isolated organism. Patients with one or more symptoms of uncomplicated recurrent urinary tract infection should undergo thorough examination and screening for underlying comorbidities that increase susceptibility. When frequent reinfections, empiric treatment relapse, persistent infections, or risk factors for complicated infections are encountered, patients may benefit from urodynamics, cystoscopy, renal ultrasound, intravenous urogram, or voiding cystourethrogram to evaluate for anatomic, functional, or metabolic abnormalities affecting the urinary tract (e.g., stones, stricture, obstruction, vesicoureteral reflux, lesions, detrusor underactivity). These patients may benefit from culture-guided empiric treatment and further evaluation by urology, nephrology, or infectious disease specialists. In patients with a history of uncomplicated urinary tract infections, empiric treatment guided by local antimicrobial resistance may efficiently treat a suspected recurrence. After successful treatment of the acute infection, postcoital prophylaxis, continuous prophylaxis, or self-start empiric treatment may be selected based on frequency of recurrent infections, temporal relation to intercourse, and patient characteristics. Ancillary measures such as probiotics, cranberry products, or local estrogen replacement may also be considered. This article will review the current definition, epidemiology, pathogenesis, diagnosis, work-up, treatment, treatment side effects, and prevention of recurrent urinary tract infections in women. A suggested algorithm for evaluation and treatment based on current literature is provided.

  1. Recurrent nontuberculous mycobacterial endophthalmitis: a diagnostic conundrum

    Directory of Open Access Journals (Sweden)

    Venkateswaran N

    2014-05-01

    infectious agent all along, and the organism was originally misidentified on the basis of less accurate tests.Conclusion: Recurrent atypical mycobacterial endophthalmitis requires expedient identification and management to prevent poor visual outcomes. Standard biochemical testing can identify the causative organism but is limited by the inability to distinguish between nontuberculous species reliably. We recommend the use of PCR in conjunction with sequencing of the hsp65 gene for reliable differentiation of M. chelonae and M. abscessus in atypical mycobacterial ocular infections. Minimum inhibitory concentration antibiotic susceptibility tests on cultured strains are the best guide to antibiotic selection, given the rapidly rising resistance to antimicrobials in atypical mycobacterial species.Keywords: atypical mycobacteria, herpes zoster ophthalmicus, hsp65, Mycobacterium chelonae, neurotrophic keratopathy, visual outcome

  2. Unattached fraction and the aerosol size distribution of the radon progeny in a natural cave and mine atmospheres

    International Nuclear Information System (INIS)

    Butterweck, G.; Porstendoerfer, J.; Reineking, A.; Kesten, J.

    1992-01-01

    Measurements of the activity size distribution of aerosol-attached radon progeny and the amount of unattached radon daughters have been performed in mine atmospheres and a tourist cave. During working hours a large number (10 5 -10 6 cm -3 ) of aerosol particles is generated in mines, mainly by diesel engines. The activity size distribution of these aerosol particles has smaller median diameters (AMAD about 200 nm) than the aged aerosol existing in the mine during non-working hours (AMAD about 350 nm). Strictly correlated to the aerosol concentration, the unattached fraction of the radon progeny, f p , in the tourist cave (3000 particles per cm 3 ) is higher (f p = 0.1) than in mines (f p 0.01) during working hours. This yields 1.4-2.5 times higher radiation dose conversion factors in the natural cave than in mines under working conditions. (author)

  3. Determination of Lung-to-Blood Absorption Rates for Lead and Bismuth which are Appropriate for Radon Progeny

    International Nuclear Information System (INIS)

    Marsh, J.W.; Birchall, A.

    1999-01-01

    The ICRP Publication 66 Human Respiratory Tract Model (HRTM) treats clearance as a competitive process between absorption into blood and particle transport to the gastrointestinal tract and lymphatics. The ICRP recommends default absorption rates for lead and bismuth in ICRP Publication 71 but states that the values are not appropriate for short-lived radon progeny. This paper describes an evaluation of published data from volunteer experiments to estimate the absorption half-times of lead and bismuth that are appropriate for short-lived radon progeny. The absorption half-time for lead was determined to be 10±2 h, based on 212 Pb lung and blood retention data from several studies. The absorption half-time for bismuth was estimated to be about 13 h, based on 212 Bi urinary excretion data from one experiment and the ICRP biokinetic model for bismuth as a decay product of lead. (author)

  4. Estimation of radiological dose from radon, thoron and their progeny levels in the dwellings of Shivamogga district, Karnataka, India

    International Nuclear Information System (INIS)

    Rangaswamvi, D.R.; Sannappa, J.; Srinivasa, E.

    2018-01-01

    Among all natural radiation exposure to man, inhalation of radon, thoron and their progenies are the major contributor (50 %) to the dose from ionizing radiation received by the general population. Based on the results of epidemiological studies in Europe and North America, the World Health Organization (WHO) has recommended reducing the indoor radon reference level from 200 to 100 Bq.m -3 . In view of this, focus has now been given for simultaneous measurement of radon, thoron and their progeny concentration in indoor air and also to estimate radiological dose in the dwellings of the Shivamogga district. The geology of the Shivamogga district comprises different types of rock formation such as granites, schists, magnetites and gneisses, Meta basalt, laterites, quartz and chlorite schist, Graywacke etc. Present study was concentrating more in granite bed rock regions along with their surrounding regions

  5. Intercomparison and intercalibration of passive/active radon and active radon progeny instruments and methods in North America

    International Nuclear Information System (INIS)

    George, A.C.; Tu, Keng W.

    1993-06-01

    An intercomparison and intercalibration exercise for radon and radon progeny measurements made with active and passive instruments was held at EML from October 22--30,1992. Twenty-five participants submitted 96 passive integrating devices, eight active devices for radon, and seven integrating devices for potential alpha energy concentration (PAEC). In addition, 40 grab samples for radon progeny analysis were taken by five groups that participated in person during the intercomparison. The results reported to EML indicate that the majority of the participants (70%) obtained mean results within 10% of the EML reference value. Although the instruments used in this exercise are based on different principles of collection and detection, they all appear reliable. However, in some instances there seemed to be some minor problems with quality control and calibration bias. Also, the large counting errors for the PAEC experienced by some of the participants can be minimized by using higher sampling air flow rates without sacrificing instrument portability

  6. Salvage endoscopic nasopharyngectomy is superior to intensity-modulated radiation therapy for local recurrence of selected T1–T3 nasopharyngeal carcinoma – A case-matched comparison

    International Nuclear Information System (INIS)

    You, Rui; Zou, Xiong; Hua, Yi-Jun; Han, Fei; Li, Li; Zhao, Chong; Hong, Ming-Huang; Chen, Ming-Yuan

    2015-01-01

    Background: Salvage ENPG and IMRT are more effective treatments for rNPC than traditional 2-dimensional radiotherapy. However, compared with IMRT, the benefits of ENPG have not yet been clearly described. Methods: We defined a resectable area in which the disease could be radically removed using ENPG and our imaging specialists selected eligible patients with tumors confined to this resectable area from a database of rNPC patients. Using propensity scores to adjust for some potential prognostic factors, a well-balanced cohort of 144 limited rNPC patients was created by matching each patient who underwent ENPG (study group) with one who underwent IMRT (control group). Morbidity, long-term oncological results, treatment-related complications, medical costs, and quality of life were compared. Results: Compared with IMRT, ENPG was associated with a relatively good overall survival (5-year OS, 77.1% vs 55.5%, P = .003), QOL conservation (mean global health status score, 57.6 vs 29.8, P < .001), and significant decreases in post-treatment complications (12.5% vs 65.3%, P < .001), medical costs (23 645.90 vs 118 122.53 Yuan, P < .001) ≈ (€2371.71 vs 11,847.80, P < .001). Conclusions: Salvage ENPG may be more effective for maximizing survival and QOL benefits and minimizing treatment-related complications and medical costs for limited rNPC patients, as compared with IMRT

  7. An analysis of phenotypic selection in natural stands of northern red oak (Quercus rubra L.)

    Science.gov (United States)

    Jeffery W. Stringer; David B. Wagner; Scott E. Schlarbaum; Daniel B. Houston

    1995-01-01

    Comparison of growth and stem quality parameters of 19-year-old progeny from superior and comparison trees indicates that rigorous phenotypic selection of trees in natural stands may not be an efficient method of parent tree selection for Quercus rubra L. Total tree height, dbh, number of branches in the butt log, fork height, and number of mainstem...

  8. Genomic selection accuracy using multi-family prediction models in a wheat breeding program

    Science.gov (United States)

    Genomic selection (GS) uses genome-wide molecular marker data to predict the genetic value of selection candidates in breeding programs. In plant breeding, the ability to produce large numbers of progeny per cross allows GS to be conducted within each family. However, this approach requires phenotyp...

  9. ANÁLISIS ESPACIAL DE VARIANZA COMO ALTERNATIVA DE EVALUACIÓN DE ENSAYOS DE PROGENIES FORESTALES

    Directory of Open Access Journals (Sweden)

    Victor Morales

    2016-01-01

    Full Text Available El uso del diseño en bloques y la aleatori - zación de las diferentes progenies en cada uno de los bloques puede ser insuficiente para el control local de la variación dentro del área del ensayo. La presencia de micro-sitios dispersos influyen en el crecimiento de los individuos, incidiendo de forma importante sobre los resultados del análisis de varianza convencional. El presente trabajo propone y describe una metodología de análisis para ensayos de progenie en la investigación forestal, que compara varios procedimientos de análisis espacial de varianzas con referencia a incorporar o no el efecto de bloque y el modelado de la tendencia superficial sobre datos registra - dos provenientes de un ensayo de Progenies de Pachira quinata (Jacq. W.S. Alverson por un periodo de 3 años de evaluación. Se estableció un protocolo de análisis que incluye diagnósti - co de correlación de los residuales, modelado de la estructura de correlación-variación y un análisis de varianza espacial. Se demostró la existencia de residuales o errores experimentales que no cumplen el supuesto de independencia, requisito fundamental para realizar un análisis de la varianza basado en diseño. El modelo con mejor ajuste fue aquel que capturó la variación superficial mediante el polinómico cúbico con el modelado de los errores correlacionados (modelo geoestadístico esférico. Las pruebas de medias de progenies estimadas por el modelo espacial con tendencia polinómica arrojó un ordenamiento diferente a las pruebas de medias estimadas bajo el análisis basado en diseño en bloques.

  10. Intercomparison of active, passive and continuous instruments for radon and radon progeny