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Sample records for profit phagosomal maturation

  1. Quantitative Spatiotemporal Analysis of Phagosome Maturation in Live Cells.

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    Schnettger, Laura; Gutierrez, Maximiliano G

    2017-01-01

    Phagocytosis and phagosome maturation are central to the development of the innate and adaptive immune response. Phagosome maturation is a continuous and dynamic process that occurs rapidly. In this chapter, we describe fluorescence-based live cell imaging methods for the quantitative and temporal analysis of phagosome maturation of latex beads and M. tuberculosis as two phagocytic targets. We also describe two simple protocols for monitoring phagosome maturation: the use of the acidotropic probe LysoTracker and analyzing the recruitment of EGFP-tagged host proteins by phagosomes.

  2. SNAP-23 regulates phagosome formation and maturation in macrophages

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    Sakurai, Chiye; Hashimoto, Hitoshi; Nakanishi, Hideki; Arai, Seisuke; Wada, Yoh; Sun-Wada, Ge-Hong; Wada, Ikuo; Hatsuzawa, Kiyotaka

    2012-01-01

    Synaptosomal associated protein of 23 kDa (SNAP-23), a plasma membrane–localized soluble N-ethylmaleimide–sensitive factor attachment protein receptor (SNARE), has been implicated in phagocytosis by macrophages. For elucidation of its precise role in this process, a macrophage line overexpressing monomeric Venus–tagged SNAP-23 was established. These cells showed enhanced Fc receptor–mediated phagocytosis. Detailed analyses of each process of phagocytosis revealed a marked increase in the production of reactive oxygen species within phagosomes. Also, enhanced accumulation of a lysotropic dye, as well as augmented quenching of a pH-sensitive fluorophore were observed. Analyses of isolated phagosomes indicated the critical role of SNAP-23 in the functional recruitment of the NADPH oxidase complex and vacuolar-type H+-ATPase to phagosomes. The data from the overexpression experiments were confirmed by SNAP-23 knockdown, which demonstrated a significant delay in phagosome maturation and a reduction in uptake activity. Finally, for analyzing whether phagosomal SNAP-23 entails a structural change in the protein, an intramolecular Förster resonance energy transfer (FRET) probe was constructed, in which the distance within a TagGFP2-TagRFP was altered upon close approximation of the N-termini of its two SNARE motifs. FRET efficiency on phagosomes was markedly enhanced only when VAMP7, a lysosomal SNARE, was coexpressed. Taken together, our results strongly suggest the involvement of SNAP-23 in both phagosome formation and maturation in macrophages, presumably by mediating SNARE-based membrane traffic. PMID:23087210

  3. Rab20 regulates phagosome maturation in RAW264 macrophages during Fc gamma receptor-mediated phagocytosis.

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    Youhei Egami

    Full Text Available Rab20, a member of the Rab GTPase family, is known to be involved in membrane trafficking, however its implication in FcγR-mediated phagocytosis is unclear. We examined the spatiotemporal localization of Rab20 during phagocytosis of IgG-opsonized erythrocytes (IgG-Es in RAW264 macrophages. By the live-cell imaging of fluorescent protein-fused Rab20, it was shown that Rab20 was transiently associated with the phagosomal membranes. During the early stage of phagosome formation, Rab20 was not localized on the membranes of phagocytic cups, but was gradually recruited to the newly formed phagosomes. Although Rab20 was colocalized with Rab5 to some extent, the association of Rab20 with the phagosomes persisted even after the loss of Rab5 from the phagosomal membranes. Then, Rab20 was colocalized with Rab7 and Lamp1, late endosomal/lysosomal markers, on the internalized phagosomes. Moreover, our analysis of Rab20 mutant expression revealed that the maturation of phagosomes was significantly delayed in cells expressing the GDP-bound mutant Rab20-T19N. These data suggest that Rab20 is an important component of phagosome and regulates the phagosome maturation during FcγR-mediated phagocytosis.

  4. Class IA phosphatidylinositol 3-kinase p110α regulates phagosome maturation.

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    Emily P Thi

    Full Text Available Of the various phosphatidylinositol 3- kinases (PI3Ks, only the class III enzyme Vps34 has been shown to regulate phagosome maturation. During studies of phagosome maturation in THP-1 cells deficient in class IA PI3K p110α, we discovered that this PI3K isoform is required for vacuole maturation to progress beyond acquisition of Rab7 leading to delivery of lysosomal markers. Bead phagosomes from THP-1 cells acquired p110α and contained PI3P and PI(3,4,5P3; however, p110α and PI(3,4,5P3 levels in phagosomes from p110α knockdown cells were decreased. Phagosomes from p110α knock down cells showed normal acquisition of both Rab5 and EEA-1, but were markedly deficient in the lysosomal markers LAMP-1 and LAMP-2, and the lysosomal hydrolase, β-galactosidase. Phagosomes from p110α deficient cells also displayed impaired fusion with Texas Red dextran-loaded lysosomes. Despite lacking lysosomal components, phagosomes from p110α deficient cells recruited normal levels of Rab7, Rab-interacting lysosomal protein (RILP and homotypic vacuole fusion and protein sorting (HOPs components Vps41 and Vps16. The latter observations demonstrated that phagosomal Rab7 was active and capable of recruiting effectors involved in membrane fusion. Nevertheless, active Rab7 was not sufficient to bring about the delivery of lysosomal proteins to the maturing vacuole, which is shown for the first time to be dependent on a class I PI3K.

  5. Ubiquitination of the PI3-kinase VPS-34 promotes VPS-34 stability and phagosome maturation.

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    Liu, Jinchao; Li, Meijiao; Li, Lin; Chen, She; Wang, Xiaochen

    2017-11-01

    Apoptotic cells generated by programmed cell death are engulfed by phagocytes and enclosed within membrane-bound phagosomes. Maturation of apoptotic cell-containing phagosomes leads to formation of phagolysosomes where cell corpses are degraded. The class III phosphatidylinositol 3-kinase (PI3-kinase) VPS-34 coordinates with PIKI-1, a class II PI3-kinase, to produce PtdIns3P on phagosomes, thus promoting phagosome closure and maturation. Here, we identified UBC-13, an E2 ubiquitin-conjugating enzyme that functions in the same pathway with VPS-34 but in parallel to PIKI-1 to regulate PtdIns3P generation on phagosomes. Loss of ubc-13 affects early steps of phagosome maturation, causing accumulation of cell corpses. We found that UBC-13 functions with UEV-1, a noncatalytic E2 variant, and CHN-1, a U-box-containing E3 ubiquitin ligase, to catalyze K63-linked poly-ubiquitination on VPS-34 both in vitro and in Caenorhabditis elegans Loss of ubc-13, uev-1, or chn-1 disrupts ubiquitin modification of VPS-34 and causes significantly reduced VPS-34 protein levels. Our data suggest that K63-linked ubiquitin modification serves as a general mechanism to modulate VPS-34 stability in multiple processes. © 2018 Liu et al.

  6. Phagosome maturation in unicellular eukaryote Paramecium: the presence of RILP, Rab7 and LAMP-2 homologues

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    E Wyroba

    2009-08-01

    Full Text Available Phagosome maturation is a complex process enabling degradation of internalised particles. Our data obtained at the gene, protein and cellular level indicate that the set of components involved in this process and known up to now in mammalian cells is functioning in unicellular eukaryote. Rab7-interacting partners: homologues of its effector RILP (Rab-interacting lysosomal protein and LAMP-2 (lysosomal membrane protein 2 as well as a7 subunit of the 26S proteasome were revealed in Paramecium phagolysosomal compartment. We identified the gene/transcript fragments encoding RILP-related proteins (RILP1 and RILP2 in Paramecium by PCR/RT-PCR and sequencing. The deduced amino acid sequences of RILP1 and RILP2 show 60.5% and 58.3% similarity, respectively, to the region involved in regulating of lysosomal morphology and dynein-dynactin recruitment of human RILP. RILP colocalised with Rab7 in Paramecium lysosomes and at phagolysosomal membrane during phagocytosis of both the latex beads and bacteria. In the same compartment LAMP-2 was present and its expression during latex internalisation was 2.5-fold higher than in the control when P2 protein fractions (100 000 x g of equal load were quantified by immunoblotting. LAMP-2 crossreacting polypeptide of ~106 kDa was glycosylated as shown by fluorescent and Western analysis of the same blot preceded by PNGase F treatment. The a7 subunit of 26S proteasome was detected close to the phagosomal membrane in the small vesicles, in some of which it colocalised with Rab7. Immunoblotting confirmed presence of RILPrelated polypeptide and a7 subunit of 26S proteasome in Paramecium protein fractions. These results suggest that Rab7, RILP and LAMP-2 may be involved in phagosome maturation in Paramecium.

  7. Gallium nanoparticles facilitate phagosome maturation and inhibit growth of virulent Mycobacterium tuberculosis in macrophages.

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    Choi, Seoung-Ryoung; Britigan, Bradley E; Moran, David M; Narayanasamy, Prabagaran

    2017-01-01

    New treatments and novel drugs are required to counter the growing problem of drug-resistant strains of Mycobacterium tuberculosis (M.tb). Our approach against drug resistant M.tb, as well as other intracellular pathogens, is by targeted drug delivery using nanoformulations of drugs already in use, as well as drugs in development. Among the latter are gallium (III) (Ga)-based compounds. In the current work, six different types of Ga and rifampin nanoparticles were prepared in such a way as to enhance targeting of M.tb infected-macrophages. They were then tested for their ability to inhibit growth of a fully pathogenic strain (H37Rv) or a non-pathogenic strain (H37Ra) of M.tb. Encapsulating Ga in folate- or mannose-conjugated block copolymers provided sustained Ga release for 15 days and significantly inhibited M.tb growth in human monocyte-derived macrophages. Nanoformulations with dendrimers encapsulating Ga or rifampin also showed promising anti-tuberculous activity. The nanoparticles co-localized with M.tb containing phagosomes, as measured by detection of mature cathepsin D (34 kDa, lysosomal hydrogenase). They also promoted maturation of the phagosome, which would be expected to increase macrophage-mediated killing of the organism. Delivery of Ga or rifampin in the form of nanoparticles to macrophages offers a promising approach for the development of new therapeutic anti-tuberculous drugs.

  8. The Monomeric GTPase Rab35 Regulates Phagocytic Cup Formation and Phagosomal Maturation in Entamoeba histolytica.

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    Verma, Kuldeep; Datta, Sunando

    2017-03-24

    One of the hallmarks of amoebic colitis is the detection of Entamoeba histolytica (Eh) trophozoites with ingested erythrocytes. Therefore, erythrophagocytosis is traditionally considered as one of the most important criteria to identify the pathogenic behavior of the amoebic trophozoites. Phagocytosis is an essential process for the proliferation and virulence of this parasite. Phagocytic cargo, upon internalization, follows a defined trafficking route to amoebic lysosomal degradation machinery. Here, we demonstrated the role of EhRab35 in the early and late phases of erythrophagocytosis by the amoeba. EhRab35 showed large vacuolar as well as punctate vesicular localization. The spatiotemporal dynamics of vacuolar EhRab35 and its exchange with soluble cytosolic pool were monitored by fluorescence recovery after photobleaching experiments. Using extensive microscopy and biochemical methods, we demonstrated that upon incubation with RBCs EhRab35 is recruited to the site of phagocytic cups as well as to the nascent phagosomes that harbor Gal/GalNAc lectin and actin. Overexpression of a dominant negative mutant of EhRab35 reduced phagocytic cup formation and thereby reduced RBC internalization, suggesting a potential role of the Rab GTPase in the cup formation. Furthermore, we also performed a phagosomal maturation assay and observed that the activated form of EhRab35 significantly increased the rate of RBC degradation. Interestingly, this mutant also significantly enhanced the number of acidic compartments in the trophozoites. Taken together, our results suggest that EhRab35 is involved in the initial stage of phagocytosis as well as in the phagolysosomal biogenesis in E. histolytica and thus contributes to the pathogenicity of the parasite. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

  9. The ESAT-6/CFP-10 secretion system of Mycobacterium marinum modulates phagosome maturation.

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    Tan, Tracy; Lee, Warren L; Alexander, David C; Grinstein, Sergio; Liu, Jun

    2006-09-01

    Virulence of Mycobacterium tuberculosis and related pathogenic mycobacteria requires the secretion of early secretory antigenic 6 kDa (ESAT-6) and culture filtrate protein 10 (CFP-10), two small proteins that lack traditional signal sequences and are exported through an alternative secretion pathway encoded primarily by the RD1 genetic locus. Mutations affecting the synthesis or secretion of ESAT-6 or CFP-10 attenuate the virulence of M. tuberculosis in murine models of infection. However, the specific functions of these proteins and of their secretion system are currently unclear. In this study, we isolated a mutant of Mycobacterium marinum defective in the secretion of ESAT-6 and CFP-10. The mutation was localized within MM5446, which is orthologous to Rv3871 of M. tuberculosis H37Rv and encodes an ATPase that is a component of the ESAT-6/CFP-10 secretion system. The mutant bacteria were unable to replicate within J774 macrophages although their growth in 7H9 medium was equivalent to the parental strain. Phagosome maturation and acidification were analysed in infected macrophages by confocal and electron microscopy using the late endosome/lysosome marker LAMP-1, along with various fluid-phase markers such as rhodamine-dextran and ferritin and the acidotropic dye LysoTracker Red. These studies demonstrated that while the wild-type parental strain of M. marinum primarily resides in a poorly acidified, non-lysosomal compartment, a significantly higher percentage of the MM5446 mutant organisms are in acidified compartments. These results suggest that the ESAT-6/CFP-10 secretion system plays a role in preventing phagolysosomal fusion, a novel function that accounts for the ability of bacteria to survive inside host cells. This finding provides a mechanism by which the ESAT-6/CFP-10 secretion system potentiates the virulence of pathogenic mycobacteria.

  10. Functional role(s) of phagosomal Rab GTPases

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    Gutierrez, Maximiliano Gabriel

    2013-01-01

    Rab GTPases are at the central node of the machinery that regulates trafficking of organelles, including phagosomes. Thanks to the unique combination of high quality phagosome purification with highly sensitive proteomic studies, the network of Rab proteins that are dynamically associated with phagosomes during the process of maturation of this organelle is relatively well known. Whereas the phagosomal functions of many of the Rab proteins associated with phagosomes are characterized, the role(s) of most of these trafficking regulators remains to be identified. In some cases, even when the function in the context of phagosome biology is described, phagosomal Rab proteins seem to have similar roles. This review summarizes the current knowledge about the identity and function of phagosomal Rab GTPases, with a particular emphasis on new evidence that clarify these seemingly overlapping Rab functions during phagosome maturation. PMID:24088602

  11. A unique Mycobacterium ESX-1 protein co-secretes with CFP-10/ESAT-6 and is necessary for inhibiting phagosome maturation.

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    Xu, Junjie; Laine, Olli; Masciocchi, Mark; Manoranjan, Joanna; Smith, Jennifer; Du, Shao Jun; Edwards, Nathan; Zhu, Xiaoping; Fenselau, Catherine; Gao, Lian-Yong

    2007-11-01

    The ESX-1 secretion system plays a critical role in the virulence of Mycobacterium tuberculosis and M. marinum. To date, three proteins are known to be secreted by ESX-1 and necessary for virulence, two of which are CFP-10 and ESAT-6. The ESX-1 secretion and the virulence mechanisms are not well understood. In this study, we have examined the M. marinum secretomes and identified four proteins specific to ESX-1. Two of those are CFP-10 and ESAT-6, and the other two are novel: MM1553 (homologous to Rv3483c) and Mh3881c (homologous to Rv3881c). We have shown that Mh3881c, CFP-10 and ESAT-6 are co-dependent for secretion. Mh3881c is being cleaved at close to the C-terminus during secretion, and the C-terminal portion is critical to the co-dependent secretion, the ESAT-6 cellular levels, and interaction with ESAT-6. The co-dependent secretion is required for M. marinum intracellular growth in macrophages, where the Mh3881c C-terminal portion plays a critical role. The role of the co-dependent secretion in intracellular growth correlates with its role in inhibiting phagosome maturation. Both the secretion and the virulence defects of the Mh3881c mutant are complemented by Mh3881c or its M. tuberculosis homologue Rv3881c, suggesting that in M. tuberculosis, Rv3881c has similar functions.

  12. Membrane proteomics of phagosomes suggests a connection to autophagy

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    Shui, Wenqing; Sheu, Leslie; Liu, Jun; Smart, Brian; Petzold, Christopher J.; Hsieh, Tsung-yen; Pitcher, Austin; Keasling*, Jay D.; Bertozzi*, Carolyn R.

    2008-11-25

    Phagocytosis is the central process by which macrophage cellsinternalize and eliminate infectious microbes as well as apoptoticcells. During maturation, phagosomes containing engulfed particlesfuse with various endosomal compartments through theaction of regulatory molecules on the phagosomal membrane. Inthis study, we performed a proteomic analysis of the membranefraction from latex bead-containing (LBC) phagosomes isolatedfrom macrophages. The profile, which comprised 546 proteins,suggests diverse functions of the phagosome and potential connectionsto secretory processes, toll-like receptor signaling, andautophagy. Many identified proteins were not previously knownto reside in the phagosome. We characterized several proteins inLBC phagosomes that change in abundance on induction of autophagy,a process that has been previously implicated in the hostdefense against microbial pathogens. These observations suggestcrosstalk between autophagy and phagocytosis that may be relevantto the innate immune response of macrophages.

  13. Profitability and risk analysis of soybean planting date by maturity group

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    Limited knowledge exists on estimated soybean yield response to planting date to determine the profit-maximizing planting date for soybean production by maturity group (MG) in the southern United States. Furthermore, determining the optimal MG and crop insurance coverage level that is preferred by r...

  14. Cystic fibrosis transmembrane conductance regulator recruitment to phagosomes in neutrophils.

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    Zhou, Yun; Song, Kejing; Painter, Richard G; Aiken, Martha; Reiser, Jakob; Stanton, Bruce A; Nauseef, William M; Wang, Guoshun

    2013-01-01

    Optimal microbicidal activity of human polymorphonuclear leukocytes (PMN) relies on the generation of toxic agents such as hypochlorous acid (HOCl) in phagosomes. HOCl formation requires H2O2 produced by the NADPH oxidase, myeloperoxidase derived from azurophilic granules, and chloride ion. Chloride transport from cytoplasm into phagosomes requires chloride channels which include cystic fibrosis transmembrane conductance regulator (CFTR), a cAMP-activated chloride channel. However, the phagosomal targeting of CFTR in PMN has not been defined. Using human peripheral blood PMN, we determined that 95-99% of lysosomal-associated membrane protein 1 (LAMP-1)-positive mature phagosomes were CFTR positive, as judged by immunostaining and flow cytometric analysis. To establish a model cell system to evaluate CFTR phagosomal recruitment, we stably expressed enhanced green fluorescent protein (EGFP) alone, EGFP-wt-CFTR and EGFP-DF508-CFTR fusion proteins in promyelocytic PLB-985 cells, respectively. After differentiation into neutrophil-like cells, CFTR presentation to phagosomes was examined. EGFP-wt-CFTR was observed to associate with phagosomes and colocalize with LAMP-1. Flow cytometric analysis of the isolated phagosomes indicated that such a phagosomal targeting was determined by the CFTR portion of the fusion protein. In contrast, significantly less EGFP-DF508-CFTR was found in phagosomes, indicating a defective targeting of the molecule to the organelle. Importantly, the CFTR corrector compound VRT-325 facilitated the recruitment of DF508-CFTR to phagosomes. These data demonstrate the possibility of pharmacologic correction of impaired recruitment of mutant CFTR, thereby providing a potential means to augment chloride supply to the phagosomes of PMN in patients with cystic fibrosis to enhance their microbicidal function. Copyright © 2013 S. Karger AG, Basel.

  15. Comparative profitability of onions harvested as green and dry (mature in Botswana

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    S.P. Baliyan

    2013-06-01

    Full Text Available This study was an attempt to calculate and compare the profitability of onions harvested as green and dry (mature in Botswana. Half of the planted onions were harvested and sold as green and half were harvested and sold as dry onions. The cost of production of green onions was 32.78% higher than the cost of production of dry onions. The irrigation and marketing expenses contributed the highest difference in the cost of production of green and dry onions. The major cost item contributing to the cost of green onions production was marketing cost (32.86% followed by irrigation cost (23.77% and harvesting cost (18.53% whereas the highest cost of production for dry onions was contributed by irrigation (38.58% followed by marketing (19.45% and planting (11.96%. The marketing cost for green onions was almost double (35.6% as compare to the dry onions (18.2%. The total return from green onions was 50.90% higher than the returns from dry onions. Gross margin of onions harvested as green was 63% higher than the gross margin from dry onions, which indicated that the production of green onions is more profitable as compare to production of dry onions. The farmers preferred onion harvested as green because it generates regular and higher returns than onions harvested as mature. Government should support farmers through some policies such as Minimum Support Price (MSP for dry onions, distribution of Mini Ferti–Seed Kit (Seeds of improved varieties and fertilizer package, construction of storages and formation of cooperatives.

  16. Two PI 3-kinases and one PI 3-phosphatase together establish the cyclic waves of phagosomal PtdIns(3P critical for the degradation of apoptotic cells.

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    Nan Lu

    2012-01-01

    Full Text Available Phosphatidylinositol 3-phosphate (PtdIns(3P is a signaling molecule important for many membrane trafficking events, including phagosome maturation. The level of PtdIns(3P on phagosomes oscillates in two waves during phagosome maturation. However, the physiological significance of such oscillation remains unknown. Currently, the Class III PI 3-kinase (PI3K Vps34 is regarded as the only kinase that produces PtdIns(3P in phagosomal membranes. We report here that, in the nematode C. elegans, the Class II PI3K PIKI-1 plays a novel and crucial role in producing phagosomal PtdIns(3P. PIKI-1 is recruited to extending pseudopods and nascent phagosomes prior to the appearance of PtdIns(3P in a manner dependent on the large GTPase dynamin (DYN-1. PIKI-1 and VPS-34 act in sequence to provide overlapping pools of PtdIns(3P on phagosomes. Inactivating both piki-1 and vps-34 completely abolishes the production of phagosomal PtdIns(3P and disables phagosomes from recruiting multiple essential maturation factors, resulting in a complete arrest of apoptotic-cell degradation. We have further identified MTM-1, a PI 3-phosphatase that antagonizes the activities of PIKI-1 and VPS-34 by down-regulating PtdIns(3P on phagosomes. Remarkably, persistent appearance of phagosomal PtdIns(3P, as a result of inactivating mtm-1, blocks phagosome maturation. Our findings demonstrate that the proper oscillation pattern of PtdIns(3P on phagosomes, programmed by the coordinated activities of two PI3Ks and one PI 3-phosphatase, is critical for phagosome maturation. They further shed light on how the temporally controlled reversible phosphorylation of phosphoinositides regulates the progression of multi-step cellular events.

  17. Two PI 3-Kinases and One PI 3-Phosphatase Together Establish the Cyclic Waves of Phagosomal PtdIns(3)P Critical for the Degradation of Apoptotic Cells

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    Lu, Nan; Shen, Qian; Mahoney, Timothy R.; Neukomm, Lukas J.; Wang, Ying; Zhou, Zheng

    2012-01-01

    Phosphatidylinositol 3-phosphate (PtdIns(3)P) is a signaling molecule important for many membrane trafficking events, including phagosome maturation. The level of PtdIns(3)P on phagosomes oscillates in two waves during phagosome maturation. However, the physiological significance of such oscillation remains unknown. Currently, the Class III PI 3-kinase (PI3K) Vps34 is regarded as the only kinase that produces PtdIns(3)P in phagosomal membranes. We report here that, in the nematode C. elegans, the Class II PI3K PIKI-1 plays a novel and crucial role in producing phagosomal PtdIns(3)P. PIKI-1 is recruited to extending pseudopods and nascent phagosomes prior to the appearance of PtdIns(3)P in a manner dependent on the large GTPase dynamin (DYN-1). PIKI-1 and VPS-34 act in sequence to provide overlapping pools of PtdIns(3)P on phagosomes. Inactivating both piki-1 and vps-34 completely abolishes the production of phagosomal PtdIns(3)P and disables phagosomes from recruiting multiple essential maturation factors, resulting in a complete arrest of apoptotic-cell degradation. We have further identified MTM-1, a PI 3-phosphatase that antagonizes the activities of PIKI-1 and VPS-34 by down-regulating PtdIns(3)P on phagosomes. Remarkably, persistent appearance of phagosomal PtdIns(3)P, as a result of inactivating mtm-1, blocks phagosome maturation. Our findings demonstrate that the proper oscillation pattern of PtdIns(3)P on phagosomes, programmed by the coordinated activities of two PI3Ks and one PI 3-phosphatase, is critical for phagosome maturation. They further shed light on how the temporally controlled reversible phosphorylation of phosphoinositides regulates the progression of multi-step cellular events. PMID:22272187

  18. Identification of Candida glabrata genes involved in pH modulation and modification of the phagosomal environment in macrophages.

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    Lydia Kasper

    Full Text Available Candida glabrata currently ranks as the second most frequent cause of invasive candidiasis. Our previous work has shown that C. glabrata is adapted to intracellular survival in macrophages and replicates within non-acidified late endosomal-stage phagosomes. In contrast, heat killed yeasts are found in acidified matured phagosomes. In the present study, we aimed at elucidating the processes leading to inhibition of phagosome acidification and maturation. We show that phagosomes containing viable C. glabrata cells do not fuse with pre-labeled lysosomes and possess low phagosomal hydrolase activity. Inhibition of acidification occurs independent of macrophage type (human/murine, differentiation (M1-/M2-type or activation status (vitamin D3 stimulation. We observed no differential activation of macrophage MAPK or NFκB signaling cascades downstream of pattern recognition receptors after internalization of viable compared to heat killed yeasts, but Syk activation decayed faster in macrophages containing viable yeasts. Thus, delivery of viable yeasts to non-matured phagosomes is likely not triggered by initial recognition events via MAPK or NFκB signaling, but Syk activation may be involved. Although V-ATPase is abundant in C. glabrata phagosomes, the influence of this proton pump on intracellular survival is low since blocking V-ATPase activity with bafilomycin A1 has no influence on fungal viability. Active pH modulation is one possible fungal strategy to change phagosome pH. In fact, C. glabrata is able to alkalinize its extracellular environment, when growing on amino acids as the sole carbon source in vitro. By screening a C. glabrata mutant library we identified genes important for environmental alkalinization that were further tested for their impact on phagosome pH. We found that the lack of fungal mannosyltransferases resulted in severely reduced alkalinization in vitro and in the delivery of C. glabrata to acidified phagosomes. Therefore

  19. The Leishmania donovani lipophosphoglycan excludes the vesicular proton-ATPase from phagosomes by impairing the recruitment of synaptotagmin V.

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    Adrien F Vinet

    2009-10-01

    Full Text Available We recently showed that the exocytosis regulator Synaptotagmin (Syt V is recruited to the nascent phagosome and remains associated throughout the maturation process. In this study, we investigated the possibility that Syt V plays a role in regulating interactions between the phagosome and the endocytic organelles. Silencing of Syt V by RNA interference revealed that Syt V contributes to phagolysosome biogenesis by regulating the acquisition of cathepsin D and the vesicular proton-ATPase. In contrast, recruitment of cathepsin B, the early endosomal marker EEA1 and the lysosomal marker LAMP1 to phagosomes was normal in the absence of Syt V. As Leishmania donovani promastigotes inhibit phagosome maturation, we investigated their potential impact on the phagosomal association of Syt V. This inhibition of phagolysosome biogenesis is mediated by the virulence glycolipid lipophosphoglycan, a polymer of the repeating Galbeta1,4Manalpha1-PO(4 units attached to the promastigote surface via an unusual glycosylphosphatidylinositol anchor. Our results showed that insertion of lipophosphoglycan into ganglioside GM1-containing microdomains excluded or caused dissociation of Syt V from phagosome membranes. As a consequence, L. donovani promatigotes established infection in a phagosome from which the vesicular proton-ATPase was excluded and which failed to acidify. Collectively, these results reveal a novel function for Syt V in phagolysosome biogenesis and provide novel insight into the mechanism of vesicular proton-ATPase recruitment to maturing phagosomes. We also provide novel findings into the mechanism of Leishmania pathogenesis, whereby targeting of Syt V is part of the strategy used by L. donovani promastigotes to prevent phagosome acidification.

  20. mTOR regulates phagosome and entotic vacuole fission.

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    Krajcovic, Matej; Krishna, Shefali; Akkari, Leila; Joyce, Johanna A; Overholtzer, Michael

    2013-12-01

    Macroendocytic vacuoles formed by phagocytosis, or the live-cell engulfment program entosis, undergo sequential steps of maturation, leading to the fusion of lysosomes that digest internalized cargo. After cargo digestion, nutrients must be exported to the cytosol, and vacuole membranes must be processed by mechanisms that remain poorly defined. Here we find that phagosomes and entotic vacuoles undergo a late maturation step characterized by fission, which redistributes vacuolar contents into lysosomal networks. Vacuole fission is regulated by the serine/threonine protein kinase mammalian target of rapamycin complex 1 (mTORC1), which localizes to vacuole membranes surrounding engulfed cells. Degrading engulfed cells supply engulfing cells with amino acids that are used in translation, and rescue cell survival and mTORC1 activity in starved macrophages and tumor cells. These data identify a late stage of phagocytosis and entosis that involves processing of large vacuoles by mTOR-regulated membrane fission.

  1. The Mycobacterium tuberculosis phagosome is a HLA-I processing competent organelle.

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    Jeff E Grotzke

    2009-04-01

    Full Text Available Mycobacterium tuberculosis (Mtb resides in a long-lived phagosomal compartment that resists maturation. The manner by which Mtb antigens are processed and presented on MHC Class I molecules is poorly understood. Using human dendritic cells and IFN-gamma release by CD8(+ T cell clones, we examined the processing and presentation pathway for two Mtb-derived antigens, each presented by a distinct HLA-I allele (HLA-Ia versus HLA-Ib. Presentation of both antigens is blocked by the retrotranslocation inhibitor exotoxin A. Inhibitor studies demonstrate that, after reaching the cytosol, both antigens require proteasomal degradation and TAP transport, but differ in the requirement for ER-golgi egress and new protein synthesis. Specifically, presentation by HLA-B8 but not HLA-E requires newly synthesized HLA-I and transport through the ER-golgi. Phenotypic analysis of the Mtb phagosome by flow organellometry revealed the presence of Class I and loading accessory molecules, including TAP and PDI. Furthermore, loaded HLA-I:peptide complexes are present within the Mtb phagosome, with a pronounced bias towards HLA-E:peptide complexes. In addition, protein analysis also reveals that HLA-E is enriched within the Mtb phagosome compared to HLA-A2. Together, these data suggest that the phagosome, through acquisition of ER-localized machinery and as a site of HLA-I loading, plays a vital role in the presentation of Mtb-derived antigens, similar to that described for presentation of latex bead-associated antigens. This is, to our knowledge, the first description of this presentation pathway for an intracellular pathogen. Moreover, these data suggest that HLA-E may play a unique role in the presentation of phagosomal antigens.

  2. Decoupling internalization, acidification and phagosomal-endosomal/lysosomal fusion during phagocytosis of InlA coated beads in epithelial cells.

    Directory of Open Access Journals (Sweden)

    Craig D Blanchette

    Full Text Available BACKGROUND: Phagocytosis has been extensively examined in 'professional' phagocytic cells using pH sensitive dyes. However, in many of the previous studies, a separation between the end of internalization, beginning of acidification and completion of phagosomal-endosomal/lysosomal fusion was not clearly established. In addition, very little work has been done to systematically examine phagosomal maturation in 'non-professional' phagocytic cells. Therefore, in this study, we developed a simple method to measure and decouple particle internalization, phagosomal acidification and phagosomal-endosomal/lysosomal fusion in Madin-Darby Canine Kidney (MDCK and Caco-2 epithelial cells. METHODOLOGY/PRINCIPAL FINDINGS: Our method was developed using a pathogen mimetic system consisting of polystyrene beads coated with Internalin A (InlA, a membrane surface protein from Listeria monocytogenes known to trigger receptor-mediated phagocytosis. We were able to independently measure the rates of internalization, phagosomal acidification and phagosomal-endosomal/lysosomal fusion in epithelial cells by combining the InlA-coated beads (InlA-beads with antibody quenching, a pH sensitive dye and an endosomal/lysosomal dye. By performing these independent measurements under identical experimental conditions, we were able to decouple the three processes and establish time scales for each. In a separate set of experiments, we exploited the phagosomal acidification process to demonstrate an additional, real-time method for tracking bead binding, internalization and phagosomal acidification. CONCLUSIONS/SIGNIFICANCE: Using this method, we found that the time scales for internalization, phagosomal acidification and phagosomal-endosomal/lysosomal fusion ranged from 23-32 min, 3-4 min and 74-120 min, respectively, for MDCK and Caco-2 epithelial cells. Both the static and real-time methods developed here are expected to be readily and broadly applicable, as they simply

  3. Tropheryma whipplei, the agent of Whipple's disease, affects the early to late phagosome transition and survives in a Rab5- and Rab7-positive compartment.

    Directory of Open Access Journals (Sweden)

    Giovanna Mottola

    Full Text Available Tropheryma whipplei, the agent of Whipple's disease, inhibits phago-lysosome biogenesis to create a suitable niche for its survival and replication in macrophages. To understand the mechanism by which it subverts phagosome maturation, we used biochemical and cell biological approaches to purify and characterise the intracellular compartment where Tropheryma whipplei resides using mouse bone-marrow-derived macrophages. We showed that in addition to Lamp-1, the Tropheryma whipplei phagosome is positive for Rab5 and Rab7, two GTPases required for the early to late phagosome transition. Unlike other pathogens, inhibition of PI(3P production was not the mechanism for Rab5 stabilisation at the phagosome. Overexpression of the inactive, GDP-bound form of Rab5 bypassed the pathogen-induced blockade of phago-lysosome biogenesis. This suggests that Tropheryma whipplei blocks the switch from Rab5 to Rab7 by acting on the Rab5 GTPase cycle. A bio-informatic analysis of the Tropheryma whipplei genome revealed a glyceraldehyde-3-phosphate dehydrogenase (GAPDH homologous with the GAPDH of Listeria monocytogenes, and this may be the bacterial protein responsible for blocking Rab5 activity. To our knowledge, Tropheryma whipplei is the first pathogen described to induce a "chimeric" phagosome stably expressing both Rab5 and Rab7, suggesting a novel and specific mechanism for subverting phagosome maturation.

  4. Salmonella typhimurium activates virulence gene transcription within acidified macrophage phagosomes.

    Science.gov (United States)

    Alpuche Aranda, C M; Swanson, J A; Loomis, W P; Miller, S I

    1992-01-01

    Survival of Salmonella typhimurium within macrophage phagosomes requires the coordinate expression of bacterial gene products. This report examines the contribution of phagosomal pH as a signal for expression of genes positively regulated by the S. typhimurium virulence regulators PhoP and PhoQ. Several hours after bacterial phagocytosis by murine bone marrow-derived macrophages, PhoP-activated gene transcription increased 50- to 77-fold. In contrast, no difference in PhoP-activated gene expression was observed after infection of cultured epithelial cells, suggesting that the membrane sensor PhoQ recognized signals unique to macrophage phagosomes. The increase in PhoP-regulated gene expression was abolished when macrophage culture medium contained NH4Cl or chloroquine, weak bases that raise the pH of acidic compartments. Measurements of pH documented that S. typhimurium delayed and attenuated acidification of its intracellular compartment. Phagosomes containing S. typhimurium required 4-5 hr to reach pH < 5.0. In contrast, within 1 hr vacuoles containing heat-killed bacteria were measured at pH < 4.5. The eventual acidification of phagosomes to pH < 5.0 correlated with the period of maximal PhoP-dependent gene expression. These observations implicate phagosome acidification as an intracellular inducer of PhoP-regulated gene expression and suggest that Salmonella survival is dependent on its ability to attenuate phagosome acidification. Images PMID:1438196

  5. Inhibition of calpain blocks the phagosomal escape of Listeria monocytogenes.

    Directory of Open Access Journals (Sweden)

    Gloria Lopez-Castejon

    Full Text Available Listeria monocytogenes is a gram-positive facultative intracellular bacterium responsible for the food borne infection listeriosis, affecting principally the immunocompromised, the old, neonates and pregnant women. Following invasion L. monocytogenes escapes the phagosome and replicates in the cytoplasm. Phagosome escape is central to L. monocytogenes virulence and is required for initiating innate host-defence responses such as the secretion of the cytokine interleukin-1. Phagosome escape of L. monocytogenes is reported to depend upon host proteins such as γ-interferon-inducible lysosomal thiol reductase and the cystic fibrosis transmembrane conductance regulator. The host cytosolic cysteine protease calpain is required in the life cycle of numerous pathogens, and previous research reports an activation of calpain by L. monocytogenes infection. Thus we sought to determine whether host calpain was required for the virulence of L. monocytogenes. Treatment of macrophages with calpain inhibitors blocked escape of L. monocytogenes from the phagosome and consequently its proliferation within the cytosol. This was independent of any direct effect on the production of bacterial virulence factors or of a bactericidal effect. Furthermore, the secretion of interleukin-1β, a host cytokine whose secretion induced by L. monocytogenes depends upon phagosome escape, was also blocked by calpain inhibition. These data indicate that L. monocytogenes co-opts host calpain to facilitate its escape from the phagosome, and more generally, that calpain may represent a cellular Achilles heel exploited by pathogens.

  6. Inhibition of calpain blocks the phagosomal escape of Listeria monocytogenes.

    Science.gov (United States)

    Lopez-Castejon, Gloria; Corbett, David; Goldrick, Marie; Roberts, Ian S; Brough, David

    2012-01-01

    Listeria monocytogenes is a gram-positive facultative intracellular bacterium responsible for the food borne infection listeriosis, affecting principally the immunocompromised, the old, neonates and pregnant women. Following invasion L. monocytogenes escapes the phagosome and replicates in the cytoplasm. Phagosome escape is central to L. monocytogenes virulence and is required for initiating innate host-defence responses such as the secretion of the cytokine interleukin-1. Phagosome escape of L. monocytogenes is reported to depend upon host proteins such as γ-interferon-inducible lysosomal thiol reductase and the cystic fibrosis transmembrane conductance regulator. The host cytosolic cysteine protease calpain is required in the life cycle of numerous pathogens, and previous research reports an activation of calpain by L. monocytogenes infection. Thus we sought to determine whether host calpain was required for the virulence of L. monocytogenes. Treatment of macrophages with calpain inhibitors blocked escape of L. monocytogenes from the phagosome and consequently its proliferation within the cytosol. This was independent of any direct effect on the production of bacterial virulence factors or of a bactericidal effect. Furthermore, the secretion of interleukin-1β, a host cytokine whose secretion induced by L. monocytogenes depends upon phagosome escape, was also blocked by calpain inhibition. These data indicate that L. monocytogenes co-opts host calpain to facilitate its escape from the phagosome, and more generally, that calpain may represent a cellular Achilles heel exploited by pathogens.

  7. Bacillus anthracis Factors for Phagosomal Escape

    Directory of Open Access Journals (Sweden)

    Irene Zornetta

    2012-07-01

    Full Text Available The mechanism of phagosome escape by intracellular pathogens is an important step in the infectious cycle. During the establishment of anthrax, Bacillus anthracis undergoes a transient intracellular phase in which spores are engulfed by local phagocytes. Spores germinate inside phagosomes and grow to vegetative bacilli, which emerge from their resident intracellular compartments, replicate and eventually exit from the plasma membrane. During germination, B. anthracis secretes multiple factors that can help its resistance to the phagocytes. Here the possible role of B. anthracis toxins, phospholipases, antioxidant enzymes and capsules in the phagosomal escape and survival, is analyzed and compared with that of factors of other microbial pathogens involved in the same type of process.

  8. Modelling phagosomal lipid networks that regulate actin assembly

    Directory of Open Access Journals (Sweden)

    Schwarz Roland

    2008-12-01

    Full Text Available Abstract Background When purified phagosomes are incubated in the presence of actin under appropriate conditions, microfilaments start growing from the membrane in a process that is affected by ATP and the lipid composition of the membrane. Isolated phagosomes are metabolically active organelles that contain enzymes and metabolites necessary for lipid interconversion. Hence, addition of ATP, lipids, and actin to the system alter the steady-state composition of the phagosomal membrane at the same time that the actin nucleation is initiated. Our aim was to model all these processes in parallel. Results We compiled detailed experimental data on the effects of different lipids and ATP on actin nucleation and we investigated experimentally lipid interconversion and ATP metabolism in phagosomes by using suitable radioactive compounds. In a first step, a complex lipid network interconnected by chemical reactions catalyzed by known enzymes was modelled in COPASI (Complex Pathway Simulator. However, several lines of experimental evidence indicated that only the phosphatidylinositol branch of the network was active, an observation that dramatically reduced the number of parameters in the model. The results also indicated that a lipid network-independent ATP-consuming activity should be included in the model. When this activity was introduced, the set of differential equations satisfactorily reproduced the experimental data. On the other hand, a molecular mechanism connecting membrane lipids, ATP, and the actin nucleation process is still missing. We therefore adopted a phenomenological (black-box approach to represent the empirical observations. We proposed that lipids and ATP influence the dynamic interconversion between active and inactive actin nucleation sites. With this simple model, all the experimental data were satisfactorily fitted with a single positive parameter per lipid and ATP. Conclusion By establishing an active 'dialogue' between an

  9. Voltage-gated proton channel is expressed on phagosomes

    Energy Technology Data Exchange (ETDEWEB)

    Okochi, Yoshifumi; Sasaki, Mari [Department of Integrative Physiology, Graduate School of Medicine, Osaka University, 2-2, Yamada-oka, Suita, Osaka 565-0871 (Japan); Department of Developmental Neurophysiology, Okazaki Institute for Integrative Bioscience, Higashiyama 5-1, Myodaiji-cho, Okazaki, Aichi 444-8787 (Japan); Iwasaki, Hirohide [Department of Developmental Neurophysiology, Okazaki Institute for Integrative Bioscience, Higashiyama 5-1, Myodaiji-cho, Okazaki, Aichi 444-8787 (Japan); Okamura, Yasushi, E-mail: yokamura@phys2.med.osaka-u.ac.jp [Department of Integrative Physiology, Graduate School of Medicine, Osaka University, 2-2, Yamada-oka, Suita, Osaka 565-0871 (Japan); Department of Developmental Neurophysiology, Okazaki Institute for Integrative Bioscience, Higashiyama 5-1, Myodaiji-cho, Okazaki, Aichi 444-8787 (Japan)

    2009-05-01

    Voltage-gated proton channel has been suggested to help NADPH oxidase activity during respiratory burst of phagocytes through its activities of compensating charge imbalance and regulation of pH. In phagocytes, robust production of reactive oxygen species occurs in closed membrane compartments, which are called phagosomes. However, direct evidence for the presence of voltage-gated proton channels in phagosome has been lacking. In this study, the expression of voltage-gated proton channels was studied by Western blot with the antibody specific to the voltage-sensor domain protein, VSOP/Hv1, that has recently been identified as the molecular correlate for the voltage-gated proton channel. Phagosomal membranes of neutrophils contain VSOP/Hv1 in accordance with subunits of NADPH oxidases, gp91, p22, p47 and p67. Superoxide anion production upon PMA activation was significantly reduced in neutrophils from VSOP/Hv1 knockout mice. These are consistent with the idea that voltage-gated proton channels help NADPH oxidase in phagocytes to produce reactive oxygen species.

  10. Profit U

    Science.gov (United States)

    Weinstein, Margery

    2012-01-01

    Preparing employees for the immediate work in front of them is a challenge. While most companies are still mastering effectively training their own workforce, some, such as "Training" magazine Top 10 Hall of Famer The Ritz-Carlton Hotel Company, have set up for-profit academies open to the public. When Ritz-Carlton won the national Malcolm…

  11. A Rab20-Dependent Membrane Trafficking Pathway Controls M. tuberculosis Replication by Regulating Phagosome Spaciousness and Integrity

    NARCIS (Netherlands)

    Schnettger, L.; Rodgers, A.; Repnik, U.; Lai, R.P.; Pei, G.; Verdoes, M.; Wilkinson, R.J.; Young, D.B.; Gutierrez, M.G.

    2017-01-01

    The intracellular pathogen Mycobacterium tuberculosis (Mtb) lives within phagosomes and also disrupts these organelles to access the cytosol. The host pathways and mechanisms that contribute to maintaining Mtb phagosome integrity have not been investigated. Here, we examined the spatiotemporal

  12. Quantitative proteomics reveals that only a subset of the endoplasmic reticulum contributes to the phagosome.

    Science.gov (United States)

    Campbell-Valois, François-Xavier; Trost, Matthias; Chemali, Magali; Dill, Brian D; Laplante, Annie; Duclos, Sophie; Sadeghi, Shayan; Rondeau, Christiane; Morrow, Isabel C; Bell, Christina; Gagnon, Etienne; Hatsuzawa, Kiyokata; Thibault, Pierre; Desjardins, Michel

    2012-07-01

    Phagosomes, by killing and degrading pathogens for antigen presentation, are organelles implicated in key aspects of innate and adaptive immunity. Although it has been well established that phagosomes consist of membranes from the plasma membrane, endosomes, and lysosomes, the notion that the endoplasmic reticulum (ER) membrane could play an important role in the formation of the phagosome is debated. However, a method to accurately estimate the contribution of potential source organelles and contaminants to the phagosome proteome has been lacking. Herein, we have developed a proteomic approach for objectively quantifying the contribution of various organelles to the early and late phagosomes by comparing these fractions to their total membrane and postnuclear supernatant of origin in the J774A.1 murine macrophage cell line. Using quantitative label-free mass spectrometry, the abundance of peptides corresponding to hundreds of proteins was estimated and attributed to one of five organelles (e.g. plasma membrane, endosomes/lysosomes, ER, Golgi, and mitochondria). These data in combination with a stable isotope labeling in cell culture method designed to detect potential contaminant sources revealed that the ER is part of the phagosomal membrane and contributes ≈ 20% of the early phagosome proteome. In addition, only a subset of ER proteins is recruited to the phagosome, suggesting that a specific subdomain(s) of the ER might be involved in phagocytosis. Western blotting and immunofluorescence substantially validated this conclusion; we were able to demonstrate that the fraction of the ER in which the ER marker GFP-KDEL accumulates is excluded from the phagosomes, whereas that containing the mVenus-Syntaxin 18 is recruited. These results highlight promising new avenues for the description of the pathogenic mechanisms used by Leishmania, Brucella, and Legionella spp., which thrive in ER-rich phagosomes.

  13. Proteomic analysis of the Ehrlichia chaffeensis phagosome in cultured DH82 cells.

    Directory of Open Access Journals (Sweden)

    Yan Cheng

    Full Text Available Ehrlichia chaffeensis is an obligately intracellular bacterium that resides and multiplies within cytoplasmic vacuoles of phagocytes. The Ehrlichia-containing vacuole (ECV does not fuse with lysosomes, an essential condition for Ehrlichia to survive inside phagocytes, but the mechanism of inhibiting the fusion of the phagosome with lysosomes is not clear. Understanding the ECV molecular composition may decipher the mechanism by which Ehrlichia inhibits phagosome-lysosome fusion. In this study, we obtained highly purified ECVs from E. chaffeensis-infected DH82 cells by sucrose density gradient centrifugation and analyzed their composition by mass spectrometry-based proteomics. The ECV composition was compared with that of phagolysosomes containing latex beads. Lysosomal proteins such as cathepsin D, cathepsin S, and lysosomal acid phosphatase were not detected in E. chaffeensis phagosome preparations. Some small GTPases, involved in membrane dynamics and phagocytic trafficking, were detected in ECVs. A notable finding was that Rab7, a late endosomal marker, was consistently detected in E. chaffeensis phagosomes by mass spectrometry. Confocal microscopy confirmed that E. chaffeensis phagosomes contained Rab7 and were acidified at approximately pH 5.2, suggesting that the E. chaffeensis vacuole was an acidified late endosomal compartment. Our results also demonstrated by mass spectrometry and immunofluorescence analysis that Ehrlichia morulae were not associated with the autophagic pathway. Ehrlichia chaffeensis did not inhibit phagosomes containing latex beads from fusing with lysosomes in infected cells. We concluded that the E. chaffeensis vacuole was a late endosome and E. chaffeensis might inhibit phagosome-lysosome fusion by modifying its vacuolar membrane composition, rather than by regulating the expression of host genes involved in trafficking.

  14. DMPD: Linking inflammasome activation and phagosome maturation. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available ml file with CIOPlayer Open .csml file with CIOPlayer - ※CIO Playerのご利用上の注意 Open .csml file with CIO Open .csml file with CIO - ※CIOのご利用上の注意 ...

  15. Personnel Policy and Profit

    DEFF Research Database (Denmark)

    Bingley, Paul; Westergård-Nielsen, Niels Chr.

    2004-01-01

    personnel structure variation. It is found that personnel policy is strongly related to economic performance. At the margin, more hires are associated with lower profit, and more separations with higher profit. For the average firm, one new job, all else equal, is associated with ?2680 (2000 prices) lower...... annual profit. Higher wage level and lower wage growth is associated with higher profit. A workforce that has less tenure, all else equal, is more profitable....

  16. Retrieval of the vacuolar H-ATPase from phagosomes revealed by live cell imaging.

    Directory of Open Access Journals (Sweden)

    Margaret Clarke

    2010-01-01

    Full Text Available The vacuolar H+-ATPase, or V-ATPase, is a highly-conserved multi-subunit enzyme that transports protons across membranes at the expense of ATP. The resulting proton gradient serves many essential functions, among them energizing transport of small molecules such as neurotransmitters, and acidifying organelles such as endosomes. The enzyme is not present in the plasma membrane from which a phagosome is formed, but is rapidly delivered by fusion with endosomes that already bear the V-ATPase in their membranes. Similarly, the enzyme is thought to be retrieved from phagosome membranes prior to exocytosis of indigestible material, although that process has not been directly visualized.To monitor trafficking of the V-ATPase in the phagocytic pathway of Dictyostelium discoideum, we fed the cells yeast, large particles that maintain their shape during trafficking. To track pH changes, we conjugated the yeast with fluorescein isothiocyanate. Cells were labeled with VatM-GFP, a fluorescently-tagged transmembrane subunit of the V-ATPase, in parallel with stage-specific endosomal markers or in combination with mRFP-tagged cytoskeletal proteins.We find that the V-ATPase is commonly retrieved from the phagosome membrane by vesiculation shortly before exocytosis. However, if the cells are kept in confined spaces, a bulky phagosome may be exocytosed prematurely. In this event, a large V-ATPase-rich vacuole coated with actin typically separates from the acidic phagosome shortly before exocytosis. This vacuole is propelled by an actin tail and soon acquires the properties of an early endosome, revealing an unexpected mechanism for rapid recycling of the V-ATPase. Any V-ATPase that reaches the plasma membrane is also promptly retrieved.Thus, live cell microscopy has revealed both a usual route and alternative means of recycling the V-ATPase in the endocytic pathway.

  17. Microtubule motors transport phagosomes in the RPE, and lack of KLC1 leads to AMD-like pathogenesis.

    Science.gov (United States)

    Jiang, Mei; Esteve-Rudd, Julian; Lopes, Vanda S; Diemer, Tanja; Lillo, Concepción; Rump, Agrani; Williams, David S

    2015-08-17

    The degradation of phagosomes, derived from the ingestion of photoreceptor outer segment (POS) disk membranes, is a major role of the retinal pigment epithelium (RPE). Here, POS phagosomes were observed to associate with myosin-7a, and then kinesin-1, as they moved from the apical region of the RPE. Live-cell imaging showed that the phagosomes moved bidirectionally along microtubules in RPE cells, with kinesin-1 light chain 1 (KLC1) remaining associated in both directions and during pauses. Lack of KLC1 did not inhibit phagosome speed, but run length was decreased, and phagosome localization and degradation were impaired. In old mice, lack of KLC1 resulted in RPE pathogenesis that was strikingly comparable to aspects of age-related macular degeneration (AMD), with an excessive accumulation of RPE and sub-RPE deposits, as well as oxidative and inflammatory stress responses. These results elucidate mechanisms of POS phagosome transport in relation to degradation, and demonstrate that defective microtubule motor transport in the RPE leads to phenotypes associated with AMD. © 2015 Jiang et al.

  18. DataProfit

    DEFF Research Database (Denmark)

    2016-01-01

    DataProfit er et værktøj til at kortlægge og analysere din virksomheds evne til datadreven forretningsudvikling.......DataProfit er et værktøj til at kortlægge og analysere din virksomheds evne til datadreven forretningsudvikling....

  19. Profit vs. Purpose

    DEFF Research Database (Denmark)

    Strand, Robert

    2017-01-01

    Money helps us meet our basic needs, but what about our need for meaning? Businesses will profit — not just financially — by finding their souls.......Money helps us meet our basic needs, but what about our need for meaning? Businesses will profit — not just financially — by finding their souls....

  20. Profit maximization mitigates competition

    DEFF Research Database (Denmark)

    Dierker, Egbert; Grodal, Birgit

    1996-01-01

    competition than utility maximization. Since profit maximization tends to raise prices, it may be regarded as beneficial for the owners as a whole. Moreover, if profit maximization is a good proxy for utility maximization, then there is no need for a general equilibrium analysis that takes the distribution...

  1. Profitable tail-end production

    Energy Technology Data Exchange (ETDEWEB)

    Pinchbeck, R.H.

    1997-12-31

    This presentation discusses the origins of the present challenge faced in making mature oil fields profitable in the North Sea. It briefly examines the origins of these challenges, which are rooted in the industrial psychology of the North Sea. It develops a methodological formula for the successful re-engineering of inefficiently-run assets, focusing in particular on the personnel management aspects. It identifies some key areas to seek sustainable cost reductions and recognises the importance of renewing the context for investment in tail-end fields. Finally, it speculates about the way in which the learnings developed in the experiences of the last few years will influence the future of the North Sea. 2 refs.

  2. For-Profit Colleges

    National Research Council Canada - National Science Library

    David Deming; Claudia Goldin; Lawrence Katz

    2013-01-01

    For-profit, or proprietary, colleges are the fastest-growing postsecondary schools in the nation, enrolling a disproportionately high share of disadvantaged and minority students and those ill-prepared for college...

  3. Combining Purpose With Profits

    DEFF Research Database (Denmark)

    Julian Birkinshaw, Julian; Foss, Nicolai Juul; Lindenberg, Siegwart

    2014-01-01

    A sense of purpose that transcends making money can motivate employees. But to sustain both a sense of purpose and a solid level of profitability over time, companies need to pay attention to several fundamental organizing principles.......A sense of purpose that transcends making money can motivate employees. But to sustain both a sense of purpose and a solid level of profitability over time, companies need to pay attention to several fundamental organizing principles....

  4. Determinants of Bank Profitability

    OpenAIRE

    Mukesh Chaudhry; Arjun Chatrath; Ravindra Kamath

    1995-01-01

    This study investigates the determinants of profitability of U.S. commercial banks in the 1970s and 1980s. It is established that banks, depending on their size, may need to exercise greater control over a defined set of variables in order to maximize profits and/or minimize costs. Further, the study provides some indirect evidence of economies of scale/scope in certain aspects of the banksÕ loan and investment portfolios.

  5. Measuring Bank Profit Efficiency

    OpenAIRE

    Fitzpatrick, Trevor; McQuinn, Kieran

    2005-01-01

    This paper proposes that a variant of the Battese and Coelli (1995) inefficiency model can be applied as a consistent and unifying framework in exploring the determinants of credit institutions’ profit inefficiency scores. To date, work concerned with the potential determinants of credit institutions' profit inefficiency levels has addressed the issue in either a single-step or multi-step process. In the former, inefficiency scores are conditioned by region and bank-specific indicators, while...

  6. Financialization and financial profit

    Directory of Open Access Journals (Sweden)

    Arturo Guillén

    2014-09-01

    Full Text Available This article starts from the critical review of the concept of financial capital. I consider it is necessary not to confuse this category with of financialization, which has acquired a certificate of naturalization from the rise of neoliberalism. Although financial monopoly-financial capital is the hegemonic segment of the bourgeoisie in the major capitalist countries, their dominance does not imply, a fortiori, financialization of economic activity, since it depends of the conditions of the process reproduction of capital. The emergence of joint stock companies modified the formation of the average rate of profit. The "promoter profit" becomes one of the main forms of income of monopoly-financial capital. It is postulated that financial profit is a kind of "extraordinary surplus-value" which is appropriated by monopoly-financial capital by means of the monopolistic control it exerts on the issue and circulation of fictitious capital.

  7. For-profit colleges.

    Science.gov (United States)

    Deming, David; Goldin, Claudia; Katz, Lawrence

    2013-01-01

    For-profit, or proprietary, colleges are the fastest-growing postsecondary schools in the nation, enrolling a disproportionately high share of disadvantaged and minority students and those ill-prepared for college. Because these schools, many of them big national chains, derive most of their revenue from taxpayer-funded student financial aid, they are of interest to policy makers not only for the role they play in the higher education spectrum but also for the value they provide their students. In this article, David Deming, Claudia Goldin, and Lawrence Katz look at the students who attend for-profits, the reasons they choose these schools, and student outcomes on a number of broad measures and draw several conclusions. First, the authors write, the evidence shows that public community colleges may provide an equal or better education at lower cost than for-profits. But budget pressures mean that community colleges and other nonselective public institutions may not be able to meet the demand for higher education. Some students unable to get into desired courses and programs at public institutions may face only two alternatives: attendance at a for-profit or no postsecondary education at all. Second, for-profits appear to be at their best with well-defined programs of short duration that prepare students for a specific occupation. But for-profit completion rates, default rates, and labor market outcomes for students seeking associate's or higher degrees compare unfavorably with those of public postsecondary institutions. In principle, taxpayer investment in student aid should be accompanied by scrutiny concerning whether students complete their course of study and subsequently earn enough to justify the investment and pay back their student loans. Designing appropriate regulations to help students navigate the market for higher education has proven to be a challenge because of the great variation in student goals and types of programs. Ensuring that potential

  8. Isolation of F. novicida-Containing Phagosome from Infected Human Monocyte Derived Macrophages

    Directory of Open Access Journals (Sweden)

    Valentina Marecic

    2017-07-01

    Full Text Available Francisella is a gram-negative bacterial pathogen, which causes tularemia in humans and animals. A crucial step of Francisella infection is its invasion of macrophage cells. Biogenesis of the Francisella-containing phagosome (FCP is arrested for ~15 min at the endosomal stage, followed by gradual bacterial escape into the cytosol, where the microbe proliferates. The crucial step in pathogenesis of tularemia is short and transient presence of the bacterium within phagosome. Isolation of FCPs for further studies has been challenging due to the short period of time of bacterial residence in it and the characteristics of the FCP. Here, we will for the first time present the method for isolation of the FCPs from infected human monocytes-derived macrophages (hMDMs. For elimination of lysosomal compartment these organelles were pre-loaded with dextran coated colloidal iron particles prior infection and eliminated by magnetic separation of the post-nuclear supernatant (PNS. We encountered the challenge that mitochondria has similar density to the FCP. To separate the FCP in the PNS from mitochondria, we utilized iodophenylnitrophenyltetrazolium, which is converted by the mitochondrial succinate dehydrogenase into formazan, leading to increased density of the mitochondria and allowing separation by the discontinuous sucrose density gradient ultracentrifugation. The purity of the FCP preparation and its acquisition of early endosomal markers was confirmed by Western blots, confocal and transmission electron microscopy. Our strategy to isolate highly pure FCPs from macrophages should facilitate studies on the FCP and its biogenesis.

  9. Medical Schools for Profit?

    African Journals Online (AJOL)

    and that funding is only spent on that will deliver more or better medical education. So staffing and other resources will be kept to the minimum required to deliver a high‑quality service. Secondly as in other walks of life, the profit motive should be a driver of innovation, and this should also be the case in medical education.

  10. From People to Profits.

    Science.gov (United States)

    Barber, L.; Hayday, S.; Bevan, S.

    An empirical test of the service-profit chain in a large United Kingdom retail business explored how employee attitudes and behavior can improve customer retention and, consequently, company sales performance. Data were collected from 65,000 employees and 25,000 customers from almost 100 stores. The business collected customer satisfaction for…

  11. The ability of Listeria monocytogenes PI-PLC to facilitate escape from the macrophage phagosome is dependent on host PKCbeta.

    Science.gov (United States)

    Poussin, Mathilde A; Leitges, Michael; Goldfine, Howard

    2009-01-01

    Listeria monocytogenes are facultative intracellular pathogenic bacteria that can infect macrophages as well as non-professional phagocytes. After entry in the host cell, the bacteria escape from the phagosome into the cytoplasm. In murine macrophages and in cell lines derived from these cells, escape of L. monocytogenes from the phagosome is absolutely dependent on listeriolysin O (LLO) and facilitated by a secreted phosphatidylinositol-specific phospholipase C (PI-PLC). Work in this laboratory has previously demonstrated a LLO and PI-PLC-dependent translocation of host PKCbeta isoforms. Pharmacological inhibition of PKCbeta resulted in a significant reduction in permeabilization of the phagosome, and in the number of bacteria reaching the cytosol. These findings led to the prediction that the bacterial PI-PLC promotes escape through the production of diacylglycerol leading to the activation of host PKCbeta. To test this hypothesis, bone marrow-derived macrophages (BMMf) obtained from PKCbeta knockout (PKCbetaKO) or C57Bl/6 mice were infected with L. monocytogenes. We observed that wild-type L. monocytogenes escapes from the phagosome of PKCbetaKO BMMf as well as from C57Bl/6 BMMf. However, in PKCbetaKO BMMf, L. monocytogenes uses a PI-PLC-independent, but phosphatidylcholine-preferring PLC (PC-PLC)-dependent pathway to facilitate escape. These findings strongly support the hypothesis that PI-PLC promotes escape through mobilization of host PKCbeta.

  12. Profit and place

    Directory of Open Access Journals (Sweden)

    Ian Bentley

    1997-01-01

    Full Text Available The article deals with the physical and symbolic effects the built environment has on human activities in a capitalist economy. The built environment is integrated in the capitalist economy on three levels: as the focus of a profit-oriented manufacturing industry, as the setting for all sorts of other enterprises and as the built context of the whole economy. The built environment is understood as a commodity. The capitalist system contains inbuilt tensions which have important design implications: the first tension arises because the system, if left to itself, lacks any overall planning functions, the second tension stems from the ability of the system to generate profit and the third arises from the character of labour, which distinguishes it from other commodities used in the production process. In conclusion methods of designing built environments, which perpetuate social order, are discussed.

  13. Determinants of Tunisian Bank Profitability

    OpenAIRE

    Raoudha Bejaoui; Houssam Bouzgarrou

    2014-01-01

    The aim of this study is to examine the persistence of profit and the effect of bank-specific determinants of Tunisian bank profitability. To account for profit persistence, we apply a dynamic panel model, using Generalized Methods of Moments (GMM) system for 16 Tunisian commercial banks, divided into 11 deposit banks and 5 development banks during the period 1999-2010. The estimates show that the evidence for profit persistence is positive and significant for both deposit and development ban...

  14. Cytoplasmic replication of Staphylococcus aureus upon phagosomal escape triggered by phenol-soluble modulin α.

    Science.gov (United States)

    Grosz, Magdalena; Kolter, Julia; Paprotka, Kerstin; Winkler, Ann-Cathrin; Schäfer, Daniel; Chatterjee, Som Subra; Geiger, Tobias; Wolz, Christiane; Ohlsen, Knut; Otto, Michael; Rudel, Thomas; Sinha, Bhanu; Fraunholz, Martin

    2014-04-01

    Staphylococcus aureus is a Gram-positive human pathogen that is readily internalized by professional phagocytes such as macrophages and neutrophils but also by non-professional phagocytes such as epithelial or endothelial cells. Intracellular bacteria have been proposed to play a role in evasion of the innate immune system and may also lead to dissemination within migrating phagocytes. Further, S. aureus efficiently lyses host cells with a battery of cytolytic toxins. Recently, phenol-soluble modulins (PSM) have been identified to comprise a genus-specific family of cytolytic peptides. Of these the PSMα peptides have been implicated in killing polymorphonuclear leucocytes after phagocytosis. We questioned if the peptides were active in destroying endosomal membranes to avoid lysosomal killing of the pathogen and monitored integrity of infected host cell endosomes by measuring the acidity of the intracellular bacterial microenvironment via flow cytometry and by a reporter recruitment technique. Isogenic mutants of the methicillin-resistant S. aureus (MRSA) strains USA300 LAC, USA400 MW2 as well as the strongly cytolytic methicillin-sensitive strain 6850 were compared with their respective wild type strains. In all three genetic backgrounds, PSMα mutants were unable to escape from phagosomes in non-professional (293, HeLa, EAhy.926) and professional phagocytes (THP-1), whereas mutants in PSMβ and δ-toxin as well as β-toxin, phosphatidyl inositol-dependent phospholipase C and Panton Valentine leucotoxin escaped with efficiencies of the parental strains. S. aureus replicated intracellularly only in presence of a functional PSMα operon thereby illustrating that bacteria grow in the host cell cytoplasm upon phagosomal escape. © 2013 John Wiley & Sons Ltd.

  15. Atg8 is involved in endosomal and phagosomal acidification in the parasitic protist Entamoeba histolytica.

    Science.gov (United States)

    Picazarri, Karina; Nakada-Tsukui, Kumiko; Tsuboi, Kumiko; Miyamoto, Eri; Watanabe, Naoko; Kawakami, Eiryo; Nozaki, Tomoyoshi

    2015-10-01

    Autophagy is one of two major bulk protein degradation systems and is conserved throughout eukaryotes. The protozoan Entamoeba histolytica, which is a human intestinal parasite, possesses a restricted set of autophagy-related (Atg) proteins compared with other eukaryotes and thus represents a suitable model organism for studying the minimal essential components and ancestral functions of autophagy. E. histolytica possesses two conjugation systems: Atg8 and Atg5/12, although a gene encoding Atg12 is missing in the genome. Atg8 is considered to be the central and authentic marker of autophagosomes, but recent studies have demonstrated that Atg8 is not exclusively involved in autophagy per se, but other fundamental mechanisms of vesicular traffic. To investigate this question in E. histolytica, we studied on Atg8 during the proliferative stage. Atg8 was constitutively expressed in both laboratory-maintained and recently established clinical isolates and appeared to be lipid-modified in logarithmic growth phase, suggesting a role of Atg8 in non-stress and proliferative conditions. These findings are in contrast to those for Entamoeba invadens, in which autophagy is markedly induced during an early phase of differentiation from the trophozoite into the cyst. The repression of Atg8 gene expression in En. histolytica by antisense small RNA-mediated transcriptional gene silencing resulted in growth retardation, delayed endocytosis and reduced acidification of endosomes and phagosomes. Taken together, these results suggest that Atg8 and the Atg8 conjugation pathway have some roles in the biogenesis of endosomes and phagosomes in this primitive eukaryote. © 2015 The Authors. Cellular Microbiology published by John Wiley & Sons Ltd.

  16. METKA - Forest energy profitably

    Energy Technology Data Exchange (ETDEWEB)

    Kymaelaeinen, M. (FMA Kanta-Hame, Hameenlinna (Finland)); Rieppo, K. (TTS Research, Hameenlinna (Finland)), e-mail: matti.kymalainen@mhy.fi, e-mail: kaarlo.rieppo@tts.fi

    2010-07-01

    The harvesting and profitability of forest energy in Finland is practically entirely dependent on state subsidies. Currently, there is a lot to improve in forest energy knowledge and competence. METKA - Forest energy profitably project (2008-2011) aims at increasing the cost efficiency of the forest energy chain and the volume of the supply chain in Haeme region. The project ia coordinated by Forest Management Association Kanta-Haeme (Kanta-Haemeen Metsanhoitoyhdistys ry). Project partners include FMA Paeijaet-Haeme, TTS Research and the Finnish Forest Research Institute's (METLA) Joensuu unit. METKA -project belongs to the Rural Development Programme for Mainland Finland 2007-2013 and is being funded partly by the European Agricultural Fund for Rural Development (EAFRD). The final project objective is to develop a new operational forest energy model for FMA Kanta-Haeme and FMA Paeijaet-Haeme. In order to create the operational model, the project has been divided into several sub-tasks, in which TTS Research and Metla are responsible for the research. TTS Research conducts studies that focus on forest energy harvesting and processing. The studies investigate especially small-diameter energy wood harvesting. Majority of the studies investigate the use of time, and they form the basis for cost and profit analyses. Metla is responsible or areas of research that contribute to the development of a forest energy storage's moisture estimation algorithm and a forest energy harvesting yield calculation program. Upon completion, the calculation program and the estimation algorithm are integrated to the logistics control system developed by FMA Kanta-Haeme and FMA Paeijaet-Haeme and taken into use as aids in forestry planning. During 2008 and 2009, several practical tests have been performed. Tests will be executed in autumn 2010 as well. The analysis of the results is likely to be completed in 2010, and the results is likely to be completed in 2010, and the results

  17. Does outsourcing affect hospital profitability?

    Science.gov (United States)

    Danvers, Kreag; Nikolov, Pavel

    2010-01-01

    Organizations outsource non-core service functions to achieve cost reductions and strategic benefits, both of which can impact profitability performance. This article examines relations between managerial outsourcing decisions and profitability for a multi-state sample of non-profit hospitals, across 16 states and four regions of the United States. Overall regression results indicate that outsourcing does not necessarily improve hospital profitability. In addition, we identify no profitability impact from outsourcing for urban hospitals, but somewhat positive effects for teaching hospitals. Our regional analysis suggests that hospitals located in the Midwest maintain positive profitability effects with outsourcing, but those located in the South realize negative effects. These findings have implications for cost reduction efforts and the financial viability of non-profit hospitals.

  18. The Service-profit Chain

    DEFF Research Database (Denmark)

    Grønholdt, Lars; Martensen, Anne

    2016-01-01

    This paper examines the links between employee attitudes, customer loyalty and company profitability. From a conceptual point of view, this employee-customer-profit chain, also known as the service-profit chain, is well founded and generally accepted. But for many companies, it seems difficult...... to demonstrate such links, and several issues must be addressed to uncover the links. To investigate these links empirically, a hotel chain provided data matching employee and customer measures with measures of profitability. We have successfully employed a modeling approach, and the paper reports empirical...... evidence of the employee-customer-profit chain. As it is possible to estimate the links, we have demonstrated their effect on company profitability. The research findings provide a better understanding of the service-profit chain and may help practitioners in improving company financial performance....

  19. THE ANALYSIS OF PROFITABILITY INDICATORS

    Directory of Open Access Journals (Sweden)

    SUCIU GHEORGHE

    2013-08-01

    Full Text Available The analysis of profitability indicators is an activity that should preoccupy all companies. Profitabilitydoes not mean only obtaining profit. A company is competitive if the ownership equity grows (the shareholders’money, the company has a profit that is comparable to that of other companies from the same area of activity,has a positive cash flow and the employees are satisfied with their salaries. Multiple indicators are used tomeasure performance: profit, commercial, economic, financial, investment rate of return, breakeven point,economic value added, net operating result.

  20. Simvastatin enhances protection against Listeria monocytogenes infection in mice by counteracting Listeria-induced phagosomal escape.

    Directory of Open Access Journals (Sweden)

    Suraj P Parihar

    Full Text Available Statins are well-known cholesterol lowering drugs targeting HMG-CoA-reductase, reducing the risk of coronary disorders and hypercholesterolemia. Statins are also involved in immunomodulation, which might influence the outcome of bacterial infection. Hence, a possible effect of statin treatment on Listeriosis was explored in mice. Statin treatment prior to subsequent L. monocytogenes infection strikingly reduced bacterial burden in liver and spleen (up to 100-fold and reduced histopathological lesions. Statin-treatment in infected macrophages resulted in increased IL-12p40 and TNF-α and up to 4-fold reduced bacterial burden within 6 hours post infection, demonstrating a direct effect of statins on limiting bacterial growth in macrophages. Bacterial uptake was normal investigated in microbeads and GFP-expressing Listeria experiments by confocal microscopy. However, intracellular membrane-bound cholesterol level was decreased, as analyzed by cholesterol-dependent filipin staining and cellular lipid extraction. Mevalonate supplementation restored statin-inhibited cholesterol biosynthesis and reverted bacterial growth in Listeria monocytogenes but not in listeriolysin O (LLO-deficient Listeria. Together, these results suggest that statin pretreatment increases protection against L. monocytogenes infection by reducing membrane cholesterol in macrophages and thereby preventing effectivity of the cholesterol-dependent LLO-mediated phagosomal escape of bacteria.

  1. Maturity Models

    DEFF Research Database (Denmark)

    Lasrado, Lester Allan; Vatrapu, Ravi

    2016-01-01

    effects, unicausal reduction, and case specificity. Based on the developments in set theoretical thinking in social sciences and employing methods like Qualitative Comparative Analysis (QCA), Necessary Condition Analysis (NCA), and set visualization techniques, in this position paper, we propose...... and demonstrate a new approach to maturity models in the domain of Information Systems. This position paper describes the set-theoretical approach to maturity models, presents current results and outlines future research work....

  2. DataProfit

    DEFF Research Database (Denmark)

    Ritter, Thomas; Lund Pedersen, Carsten; Eibe Sørensen, Hans

    Mange erhvervsledere har store forventninger til at bruge data til at tjene penge i deres virksomheder. Dog viser det sig, at det ikke er så ligetil – mange forventninger bliver simpelthen ikke indfriet. Derfor har vi igennem de seneste to år kortlagt de kompetencer, som er nødvendige for at real......Mange erhvervsledere har store forventninger til at bruge data til at tjene penge i deres virksomheder. Dog viser det sig, at det ikke er så ligetil – mange forventninger bliver simpelthen ikke indfriet. Derfor har vi igennem de seneste to år kortlagt de kompetencer, som er nødvendige...... sammen for at udnytte mulighederne for datadreven profitabel vækst. Denne guide giver en anvendelsesorienteret gennemgang af de ni kompetencer i vores kort, som vi kalder for DataProfit. I guiden beskrives hver kompetence – og du inviteres til at analysere din virksomhed. Til sidst sætter vi hele...

  3. Profit Patterns Across American Agriculture

    OpenAIRE

    Blank, Steven C.; Erickson, Kenneth W.; Moss, Charles B.

    2005-01-01

    To remain viable, agriculture in each location must offer returns that are competitive with those from alternative investments and sufficient to cover producers' financial obligations. Economic theory says that rates of return converge over time as resources flow into more-profitable industries and out of less-profitable industries, causing factor price changes. Both traditional growth and trade theories say factor markets will adjust to equalize commodity returns over time. This study examin...

  4. Electronic Payments Profitability Extent Model

    Directory of Open Access Journals (Sweden)

    Rudolf Vohnout

    2016-12-01

    Full Text Available Cashless payments are recent phenomena, which even increased with the introduction of contactless means like NFC, PayPass or payWave. Such new methods speed-up the entire payment process and in comparison to cash transactions are much simpler and faster. But on the other hand the key question for merchant is if it is worth to have such device, which accept these new payment means or not to have the terminal at all. What is the amount of cash flow, which delimits the cash holdings to be still profitable? This paper tries to give answers to such question by presenting general profitability model, which will address defining the cash threshold amount. The aim is to show that cash holdings could be profitable up to certain amount, but after the threshold is met, cashless payment methods are fairly superior despite their additional costs.

  5. ER-Coordinated Activities of Rab22a and Rab5a Drive Phagosomal Compaction and Intracellular Processing of Borrelia burgdorferi by Macrophages

    Directory of Open Access Journals (Sweden)

    Xenia Naj

    2015-09-01

    Full Text Available Borrelia burgdorferi is the causative agent of Lyme disease, a multisystemic disorder affecting the skin, joints, and nervous system. Macrophages and dendritic cells counteract Borrelia dissemination through internalization and degradation of spirochetes. We now show that Borrelia internalization by primary human macrophages involves uptake and compaction into Rab22a-positive phagosomes that are in close contact with Rab5a-positive vesicles. Compaction of borreliae involves membrane extrusion from phagosomes, is driven by Rab22a and Rab5a activity, and is coordinated by ER tubules forming contact sites of Rab22a phagosomes with Rab5a vesicles. Importantly, Rab22a and Rab5a depletion leads to reduced localization to lysosomes and to increased intracellular survival of spirochetes. These data show that Rab22a- and Rab5a-driven phagosomal uptake is a crucial step in the vesicular cascade that leads to elimination of spirochetes by macrophages. Rab22a and Rab5a thus present as potential molecular targets for the modulation of intracellular processing of borreliae in human immune cells.

  6. Profitability analysis of KINGLONG nearly 5 years

    Science.gov (United States)

    Zhang, Mei; Wen, Jinghua

    2017-08-01

    Profitability analysis for measuring business performance and forecast its prospects play an important role. In this paper, the research instance King Long Motor in understanding the basic theory on the basis of financial management, to take a combination of theory and data analysis methods, combined with a measure of profitability related indicators of King Long Motor company’s profitability do a specific analysis to identify factors constraining the profitability of Kinglong company exists and the motivation to improve profitability, which made recommendations to improve the profitability of Kinglong car company to promote the company’s future can be better and faster development.)

  7. Profitability of Residential Battery Energy Storage Combined with Solar Photovoltaics

    Directory of Open Access Journals (Sweden)

    Christoph Goebel

    2017-07-01

    Full Text Available Lithium-ion (Li-Ion batteries are increasingly being considered as bulk energy storage in grid applications. One such application is residential energy storage combined with solar photovoltaic (PV panels to enable higher self-consumption rates, which has become financially more attractive recently due to decreasing feed-in subsidies. Although residential energy storage solutions are commercially mature, it remains unclear which system configurations and circumstances, including aggregator-based applications such as the provision of ancillary services, lead to profitable consumer investments. Therefore, we conduct an extensive simulation study that is able to jointly capture these aspects. Our results show that, at current battery module prices, even optimal system configurations still do not lead to profitable investments into Li-Ion batteries if they are merely used as a buffer for solar energy. The first settings in which they will become profitable, as prices are further declining, will be larger households at locations with higher average levels of solar irradiance. If the batteries can be remote-controlled by an aggregator to provide overnight negative reserve, their profitability increases significantly.

  8. A Decomposition of Hospital Profitability

    Directory of Open Access Journals (Sweden)

    Jason Turner

    2015-06-01

    Full Text Available Objectives: This paper evaluates the drivers of profitability for a large sample of U.S. hospitals. Following a methodology frequently used by financial analysts, we use a DuPont analysis as a framework to evaluate the quality of earnings. By decomposing returns on equity (ROE into profit margin, total asset turnover, and capital structure, the DuPont analysis reveals what drives overall profitability. Methods: Profit margin, the efficiency with which services are rendered (total asset turnover, and capital structure is calculated for 3,255 U.S. hospitals between 2007 and 2012 using data from the Centers for Medicare & Medicaid Services’ Healthcare Cost Report Information System (CMS Form 2552. The sample is then stratified by ownership, size, system affiliation, teaching status, critical access designation, and urban or non-urban location. Those hospital characteristics and interaction terms are then regressed (OLS against the ROE and the respective DuPont components. Sensitivity to regression methodology is also investigated using a seemingly unrelated regression. Results: When the sample is stratified by hospital characteristics, the results indicate investor-owned hospitals have higher profit margins, higher efficiency, and are substantially more leveraged. Hospitals in systems are found to have higher ROE, margins, and efficiency but are associated with less leverage. In addition, a number of important and significant interactions between teaching status, ownership, location, critical access designation, and inclusion in a system are documented. Many of the significant relationships, most notably not-for-profit ownership, lose significance or are predominately associated with one interaction effect when interaction terms are introduced as explanatory variables. Results are not sensitive to the alternative methodology. Conclusion: The results of the DuPont analysis suggest that although there appears to be convergence in the behavior of

  9. A Decomposition of Hospital Profitability

    Science.gov (United States)

    Broom, Kevin; Elliott, Michael; Lee, Jen-Fu

    2015-01-01

    Objectives: This paper evaluates the drivers of profitability for a large sample of U.S. hospitals. Following a methodology frequently used by financial analysts, we use a DuPont analysis as a framework to evaluate the quality of earnings. By decomposing returns on equity (ROE) into profit margin, total asset turnover, and capital structure, the DuPont analysis reveals what drives overall profitability. Methods: Profit margin, the efficiency with which services are rendered (total asset turnover), and capital structure is calculated for 3,255 U.S. hospitals between 2007 and 2012 using data from the Centers for Medicare & Medicaid Services’ Healthcare Cost Report Information System (CMS Form 2552). The sample is then stratified by ownership, size, system affiliation, teaching status, critical access designation, and urban or non-urban location. Those hospital characteristics and interaction terms are then regressed (OLS) against the ROE and the respective DuPont components. Sensitivity to regression methodology is also investigated using a seemingly unrelated regression. Results: When the sample is stratified by hospital characteristics, the results indicate investor-owned hospitals have higher profit margins, higher efficiency, and are substantially more leveraged. Hospitals in systems are found to have higher ROE, margins, and efficiency but are associated with less leverage. In addition, a number of important and significant interactions between teaching status, ownership, location, critical access designation, and inclusion in a system are documented. Many of the significant relationships, most notably not-for-profit ownership, lose significance or are predominately associated with one interaction effect when interaction terms are introduced as explanatory variables. Results are not sensitive to the alternative methodology. Conclusion: The results of the DuPont analysis suggest that although there appears to be convergence in the behavior of NFP and IO

  10. An ethical justification of profit maximization

    DEFF Research Database (Denmark)

    Koch, Carsten Allan

    2010-01-01

    behaviour. It is argued that some form of consequential ethics must be applied, and that both profit seeking and profit maximization can be defended from a rule-consequential point of view. It is noted, however, that the result does not apply unconditionally, but requires that certain form of profit (and...

  11. 40 CFR 35.936-4 - Profits.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Profits. 35.936-4 Section 35.936-4... ASSISTANCE Grants for Construction of Treatment Works-Clean Water Act § 35.936-4 Profits. Only fair and reasonable profits may be earned by contractors in subagreements under EPA grants. See § 35.937-7 for...

  12. Measuring Customer Profitability in Complex Environments

    DEFF Research Database (Denmark)

    Holm, Morten; Kumar, V.; Rohde, Carsten

    2012-01-01

    that the degree of sophistication deployed when implementing customer profitability measurement models is determined by the type of complexity encountered in firms’ customer environments. This gives rise to a contingency framework for customer profitability measurement model selection and five research......Customer profitability measurement is an important element in customer relationship management and a lever for enhanced marketing accountability. Two distinct measurement approaches have emerged in the marketing literature: Customer Lifetime Value (CLV) and Customer Profitability Analysis (CPA...... propositions. Additionally, the framework provides design and implementation guidance for managers seeking to implement customer profitability measurement models for resource allocation purposes....

  13. Maturity and maturity models in lean construction

    National Research Council Canada - National Science Library

    Nesensohn, Claus; Bryde, David; Ochieng, Edward; Fearon, Damian

    2014-01-01

    ...; which reflects a growing recognition that becoming more mature and having a model to guide the route to maturity can help organisations in managing major transformational change. Lean Construction (LC...

  14. The type I NADH dehydrogenase of Mycobacterium tuberculosis counters phagosomal NOX2 activity to inhibit TNF-alpha-mediated host cell apoptosis.

    Directory of Open Access Journals (Sweden)

    Jessica L Miller

    2010-04-01

    Full Text Available The capacity of infected cells to undergo apoptosis upon insult with a pathogen is an ancient innate immune defense mechanism. Consequently, the ability of persisting, intracellular pathogens such as the human pathogen Mycobacterium tuberculosis (Mtb to inhibit infection-induced apoptosis of macrophages is important for virulence. The nuoG gene of Mtb, which encodes the NuoG subunit of the type I NADH dehydrogenase, NDH-1, is important in Mtb-mediated inhibition of host macrophage apoptosis, but the molecular mechanism of this host pathogen interaction remains elusive. Here we show that the apoptogenic phenotype of MtbDeltanuoG was significantly reduced in human macrophages treated with caspase-3 and -8 inhibitors, TNF-alpha-neutralizing antibodies, and also after infection of murine TNF(-/- macrophages. Interestingly, incubation of macrophages with inhibitors of reactive oxygen species (ROS reduced not only the apoptosis induced by the nuoG mutant, but also its capacity to increase macrophage TNF-alpha secretion. The MtbDeltanuoG phagosomes showed increased ROS levels compared to Mtb phagosomes in primary murine and human alveolar macrophages. The increase in MtbDeltanuoG induced ROS and apoptosis was abolished in NOX-2 deficient (gp91(-/- macrophages. These results suggest that Mtb, via a NuoG-dependent mechanism, can neutralize NOX2-derived ROS in order to inhibit TNF-alpha-mediated host cell apoptosis. Consistently, an Mtb mutant deficient in secreted catalase induced increases in phagosomal ROS and host cell apoptosis, both of which were dependent upon macrophage NOX-2 activity. In conclusion, these results serendipitously reveal a novel connection between NOX2 activity, phagosomal ROS, and TNF-alpha signaling during infection-induced apoptosis in macrophages. Furthermore, our study reveals a novel function of NOX2 activity in innate immunity beyond the initial respiratory burst, which is the sensing of persistent intracellular pathogens

  15. Inositol Polyphosphate-4-Phosphatase Type I Negatively Regulates Phagocytosis via Dephosphorylation of Phagosomal PtdIns(3,4P2.

    Directory of Open Access Journals (Sweden)

    Kiyomi Nigorikawa

    Full Text Available Phagocytosis is a highly conserved process whereby phagocytic cells engulf pathogens and apoptotic bodies. The present study focused on the role of inositol polyphosphate-4-phosphatase type I (Inpp4a in phagocytosis. Raw264.7 cells that express shRNA against Inpp4a (shInpp4a cells showed significantly increased phagocytic activity. The introduction of shRNA-resistant human Inpp4a abolished this increase. Macrophages from Inpp4a knockout mice showed similar increases in the phagocytic activity. Inpp4a was recruited to the phagosome membrane by a mechanism other than the direct interaction with Rab5. PtdIns(3,4P2 increased on the phagosome of shInpp4a cells, while PtdIns(3P significantly decreased. The results indicate that Inpp4a negatively regulates the phagocytic activity of macrophages as a member of the sequential dephosphorylation system that metabolizes phagosomal PtdIns(3,4,5P3 to PtdIns(3P.

  16. Impact of robotic operative efficiency on profitability.

    Science.gov (United States)

    Geller, Elizabeth J; Matthews, Catherine A

    2013-07-01

    We sought to determine the impact of robotic operative efficiency on profitability and assess the impact of secondary variables. Financial data were collected for all robotic cases performed for fiscal years 2010 (FY10) and 2011 (FY11) at University of North Carolina at Chapel Hill, and included 9 surgical subspecialties. Profitability was defined as a positive operating income. From July 2009 through June 2011, 1295 robotic cases were performed. Robotic surgery was profitable in both fiscal years, with an operating income of $386,735 in FY10 and $822,996 in FY11. In FY10, urogynecology and pediatric surgery were the only nonprofitable subspecialties. In FY11, all subspecialties were profitable. Profitability was associated with case time, payor mix, and procedure type (all P profitability regardless of surgical specialty. Copyright © 2013 Mosby, Inc. All rights reserved.

  17. Analyzing profit efficiency of banks in India with undesirable output – Nerlovian profit indicator approach

    Directory of Open Access Journals (Sweden)

    A.R. Jayaraman

    2014-12-01

    Full Text Available The objective of this paper is to provide a holistic approach to measure the profit efficiency of banks, factoring desirable/undesirable outputs, using Nerlovian profit indicator approach. The profit inefficiency of banks has been decomposed into technical and allocation inefficiency using directional distance function. Results reveal that profit inefficiency of banks is primarily due to allocative inefficiency and the impact of technical inefficiency on profit inefficiency is minimal compared to allocative inefficiency, which indicates that banks need to focus on optimal utilization of input–output mix to enhance profit efficiency.

  18. Profitable use of bio fuels

    Energy Technology Data Exchange (ETDEWEB)

    Ekelund, Mats [Strateco Develoment AB, Vega (Sweden)], e-mail: mats.e@strateco.se

    2012-11-01

    Traditionally, the transportation industry has been opposed to any new legislation and when rather stringent emission legislation occurred, they objected just as they did when new fuels came on the agenda. On very short notice, Taxi Stockholm lost 20 % of their business when the County decided to award all public transportation contracts to a competitor. It was time to change plans instead of complaining and to take advantage of new opportunities - 'The first mover advantage'. Making the use of bio fuels into a profitable business takes a change of a standard 'business model' to do and there is still much room others to do the same. With a new CEO, an active marketing department and active individuals among the Board of Directors, Taxi Stockholm massaged a strategy where more business and private customers would be attracted by justifying the green leaf on every cab. All initiatives were publically announced and Taxi Stockholm broke new ice by putting a ban on spike tires - a decision which the vice Mayor made part of her ruling for the whole city. The Ban on gasoline and diesel cars were announced and such a statement attracted business from a loyalty point of view and from companies that had a 'Green Transport Policy' to live up to. Taxi Stockholm has seen growth and profitability grow since and credit the green policy on bio fuels such as bio gas and ethanol for most of it. Preem, Stockholm Transit, Volvo and other market driven operators have all seen markets grow from green initiatives.

  19. The Persistence of Shocks to Profitability

    OpenAIRE

    Anita M McGahan; Porter, Michael E.

    1999-01-01

    In this study, we use data for 1981 through 1994 on a large sample of U.S. companies to examine the persistence of incremental industry, corporate-parent, and business-specific effects on profitability. Our results indicate that the incremental effects of industry on profitability persist longer than the incremental effects of the corporate parent and of the specific business. Changes in industry structure have a more persistent impact on profitability than do changes in firm structure. © 199...

  20. The Choice of For-Profit College

    OpenAIRE

    Chung, Anna

    2008-01-01

    In this paper I investigate whether students self-select into the US for-profit colleges or whether the choice of for-profit sector is accidental or due to the reasons external to the students (geographic exposure to for-profit providers, tuition pricing, or random circumstances). The main student-level data samples come from the National Education Longitudinal Study of 1988 (NELS:88) and the associated Postsecondary Education Transcript Study (PETS:2000). I estimate a multinomial logit of co...

  1. Farm profitability and Labour Use Efficiency

    OpenAIRE

    Amarender A, Reddy

    2013-01-01

    Appropriate choice of cropping systems to local agro-ecology increases profitability and employment. The increased labour shortage and reduced profitability are growing concerns to the farmers. Keeping this, the paper written with the following objectives: i) To assess the profitability among different cropping systems in the semi-arid tropics; ii) To assess the labour use pattern among different cropping systems and farm size; iii) To determine the resource use efficiency of the different cr...

  2. The transcriptomic response of the coral Acropora digitifera to a competent Symbiodinium strain: the symbiosome as an arrested early phagosome.

    Science.gov (United States)

    Mohamed, A R; Cumbo, V; Harii, S; Shinzato, C; Chan, C X; Ragan, M A; Bourne, D G; Willis, B L; Ball, E E; Satoh, N; Miller, D J

    2016-07-01

    Despite the ecological significance of the relationship between reef-building corals and intracellular photosynthetic dinoflagellates of the genus Symbiodinium, very little is known about the molecular mechanisms involved in its establishment. Indeed, microarray-based analyses point to the conclusion that host gene expression is largely or completely unresponsive during the establishment of symbiosis with a competent strain of Symbiodinium. In this study, the use of Illumina RNA-Seq technology allowed detection of a transient period of differential expression involving a small number of genes (1073 transcripts; competent strain of Symbiodinium (a clade B strain). This phenomenon has not previously been detected as a consequence of both the lower sensitivity of the microarray approaches used and the sampling times used. The results indicate that complex changes occur, including transient suppression of mitochondrial metabolism and protein synthesis, but are also consistent with the hypothesis that the symbiosome is a phagosome that has undergone early arrest, raising the possibility of common mechanisms in the symbiotic interactions of corals and symbiotic sea anemones with their endosymbionts. © 2016 John Wiley & Sons Ltd.

  3. Emissions trading and profit-neutral grandfathering

    Energy Technology Data Exchange (ETDEWEB)

    Hepburn, Cameron; Ritz, Robert; Quah, John (Oxford Univ., Smith School of Enterprise and the Environment, Oxford (United Kingdom))

    2008-07-01

    This paper examines the amount of grandfathering needed for an emissions trading scheme (ETS) to have a neutral impact on firm profits. We provide a simple formula to calculate profit-neutral grandfathering in an asymmetric Cournot model with a general demand function. Using this formula, we obtain estimates of profit-neutral grandfathering for the electricity, cement, newsprint and steel industries. Under the current EU ETS, firms obtain close to full grandfathering. We find no evidence that any industry as a whole could be worse off with full grandfathering. We also show that the common presumption that a higher rate of cost pass-through lowers profit-neutral grandfathering is unreliable

  4. Color back projection for fruit maturity evaluation

    Science.gov (United States)

    Zhang, Dong; Lee, Dah-Jye; Desai, Alok

    2013-12-01

    In general, fruits and vegetables such as tomatoes and dates are harvested before they fully ripen. After harvesting, they continue to ripen and their color changes. Color is a good indicator of fruit maturity. For example, tomatoes change color from dark green to light green and then pink, light red, and dark red. Assessing tomato maturity helps maximize its shelf life. Color is used to determine the length of time the tomatoes can be transported. Medjool dates change color from green to yellow, and the orange, light red and dark red. Assessing date maturity helps determine the length of drying process to help ripen the dates. Color evaluation is an important step in the processing and inventory control of fruits and vegetables that directly affects profitability. This paper presents an efficient color back projection and image processing technique that is designed specifically for real-time maturity evaluation of fruits. This color processing method requires very simple training procedure to obtain the frequencies of colors that appear in each maturity stage. This color statistics is used to back project colors to predefined color indexes. Fruit maturity is then evaluated by analyzing the reprojected color indexes. This method has been implemented and used for commercial production.

  5. Education for Profit, Education for Freedom

    Science.gov (United States)

    Nussbaum, Martha C.

    2009-01-01

    Education is often discussed in low-level utilitarian terms: how can educators produce technically trained people who can hold onto "their" share of the global market? With the rush to profitability, values precious for the future of democracy are in danger of getting lost. The profit motive suggests to most concerned politicians that science and…

  6. Corporate Social Responsibility and Profit Maximizing Behaviour

    OpenAIRE

    Becchetti, Leonardo; Giallonardo, Luisa; Tessitore, Maria Elisabetta

    2005-01-01

    We examine the behavior of a profit maximizing monopolist in a horizontal differentiation model in which consumers differ in their degree of social responsibility (SR) and consumers SR is dynamically influenced by habit persistence. The model outlines parametric conditions under which (consumer driven) corporate social responsibility is an optimal choice compatible with profit maximizing behavior.

  7. Price Discrimination, Economies of Scale, and Profits.

    Science.gov (United States)

    Park, Donghyun

    2000-01-01

    Demonstrates that it is possible for economies of scale to induce a price-discriminating monopolist to sell in an unprofitable market where the average cost always exceeds the price. States that higher profits in the profitable market caused by economies of scale may exceed losses incurred in the unprofitable market. (CMK)

  8. Cooperation and profit allocation in distribution chains

    NARCIS (Netherlands)

    Guardiola, Luis A.; Meca, Ana; Timmer, Judith B.

    2007-01-01

    We study the coordination of actions and the allocation of profit in supply chains under decentralized control in which a single supplier supplies several retailers with goods for replenishment of stocks. The goal of the supplier and the retailers is to maximize their individual profits. Since the

  9. Risk Management And Organisational Profitability | Ukandu ...

    African Journals Online (AJOL)

    The level of growth and profit maximization in the oil industry has been impaired by a lot of risks. Risk control measures and effective plan are used to reduce the occurrence of such risks. Also, proper risk evaluation techniques are used to evaluate the cost implication of risk on production and the profitability level of such ...

  10. Will farm profits shift in 2013?

    OpenAIRE

    Nathan Kauffman

    2012-01-01

    Despite a severe drought, profits in the U.S. farm sector soared in 2012. Beginning in late June, U.S. crops and pastures wilted under one of the worst droughts in history. Although total farm incomes remained high, the drought exacerbated a widening gulf in profitability between the crop and livestock sectors.

  11. relating customer satisfaction to customer profitability

    African Journals Online (AJOL)

    PROF EKWUEME

    carried out by marketing scholars. This is not likely to advance marketing theory. After all, accounting to profitability lies at the heart of the marketing concept, Kohli & Jaworski (1990:1-18) and Narver and Slater (1990:35). Similarly, according to Buttle (1996) marketing's link to profitability is stressed in the definitions of.

  12. Determinants of Iranian bank profitability

    Directory of Open Access Journals (Sweden)

    Hassan Ghodrati

    2014-04-01

    Full Text Available Banks are the most important tool for preparing and supplying money in each country. In recent years, by institution of the new private banks and privatization of the governmental banks, banking competition has become very complex. This paper performs an empirical investigation to study the effects of different factors on return on assets and return on equities on 18 selected Iranian firms over the period 2002-2011. Using different regression models, the study studies the effects of total assets, debt ratio, etc. on return of assets (ROA and return on equities (ROE on selected eighteen Iranian banks as statistical community. The study considers total assets, ownership ratio, deposits to assets ratio, and loans to assets ratio as independent variables, and ROE and ROA as dependent variables. The results indicate that the private banks returns were better than governmental banks and the commercial banks’ returns were better than special banks. There is a reverse relationship between logarithm of total assets and ownership ratio with profitability based on return of assets.

  13. Profiting from innovative user communities

    DEFF Research Database (Denmark)

    Jeppesen, Lars Bo

    Modding - the modification of existing products by consumers - is increasingly exploited by manufacturers to enhance product development and sales. In the computer games industry modding has evolved into a development model in which users act as unpaid `complementors' to manufacturers' product pl......, a manufacturer can incorporate and commercialize the best complements found in the user communities. Keywords: innovation, modding, user communities, software platform, business model. JEL code(s): L21; L23; O31; O32...... platforms. This article explains how manufacturers can profit from their abilities to organize and facilitate a process of innovation by user communities and capture the value of the innovations produced in such communities. When managed strategically, two distinct, but not mutually exclusive business...... models appear from the production of user complements: firstly, a manufacturer can let the (free) user complements `drift' in the user communities, where they increase the value to consumers of owning the given platform and thus can be expected to generate increased platform sales, and secondly...

  14. Profitability Analysis of Soybean Oil Processes

    Directory of Open Access Journals (Sweden)

    Ming-Hsun Cheng

    2017-10-01

    Full Text Available Soybean oil production is the basic process for soybean applications. Cash flow analysis is used to estimate the profitability of a manufacturing venture. Besides capital investments, operating costs, and revenues, the interest rate is the factor to estimate the net present value (NPV, break-even points, and payback time; which are benchmarks for profitability evaluation. The positive NPV and reasonable payback time represent a profitable process, and provide an acceptable projection for real operating. Additionally, the capacity of the process is another critical factor. The extruding-expelling process and hexane extraction are the two typical approaches used in industry. When the capacities of annual oil production are larger than 12 and 173 million kg respectively, these two processes are profitable. The solvent free approach, known as enzyme assisted aqueous extraction process (EAEP, is profitable when the capacity is larger than 17 million kg of annual oil production.

  15. Profitability Analysis of Soybean Oil Processes.

    Science.gov (United States)

    Cheng, Ming-Hsun; Rosentrater, Kurt A

    2017-10-07

    Soybean oil production is the basic process for soybean applications. Cash flow analysis is used to estimate the profitability of a manufacturing venture. Besides capital investments, operating costs, and revenues, the interest rate is the factor to estimate the net present value (NPV), break-even points, and payback time; which are benchmarks for profitability evaluation. The positive NPV and reasonable payback time represent a profitable process, and provide an acceptable projection for real operating. Additionally, the capacity of the process is another critical factor. The extruding-expelling process and hexane extraction are the two typical approaches used in industry. When the capacities of annual oil production are larger than 12 and 173 million kg respectively, these two processes are profitable. The solvent free approach, known as enzyme assisted aqueous extraction process (EAEP), is profitable when the capacity is larger than 17 million kg of annual oil production.

  16. Maturity and maturity models in lean construction

    Directory of Open Access Journals (Sweden)

    Claus Nesensohn

    2014-03-01

    Full Text Available In recent years there has been an increasing interest in maturity models in management-related disciplines; which reflects a growing recognition that becoming more mature and having a model to guide the route to maturity can help organisations in managing major transformational change. Lean Construction (LC is an increasingly important improvement approach that organisations seek to embed. This study explores how to apply the maturity models to LC. Hence the attitudes, opinions and experiences of key industry informants with high levels of knowledge of LC were investigated. To achieve this, a review of maturity models was conducted, and data for the analysis was collected through a sequential process involving three methods. First a group interview with seven key informants. Second a follow up discussion with the same individuals to investigate some of the issues raised in more depth. Third an online discussion held via LinkedIn in which members shared their views on some of the results. Overall, we found that there is a lack of common understanding as to what maturity means in LC, though there is general agreement that the concept of maturity is a suitable one to reflect the path of evolution for LC within organisations.

  17. Slab replacement maturity guidelines.

    Science.gov (United States)

    2014-04-01

    This study investigated the use of maturity method to determine early age strength of concrete in slab : replacement application. Specific objectives were (1) to evaluate effects of various factors on the compressive : maturity-strength relationship ...

  18. New high profitable wind turbines

    Energy Technology Data Exchange (ETDEWEB)

    Frankovic, Bernard [Rijeka Univ., Faculty of Engineering, Rijeka (Croatia); Vrsalovic, Ivan [Rijekaprojekt d.o.o., Rijeka (Croatia)

    2001-11-01

    To generate more quantities of electric energy from wind it is necessary to use a new type of wind turbine built in the regulable mantle's nozzle. This wind turbine type replaces the free air stream from wind by a programmed, i.e. regulated, and partially concentrated stream of air. The nozzle shell is designed as an aerodynamically shaped ring with wings with its lower pressure side pointed towards the centre so that the lift force on each part of the wing is directed radially towards the centre. This induces centrifugal reaction force in the airflow that causes the stream field to expand strongly downstream of the rotor and includes a greater number of streamlines in the active stream in front of the rotor (upstream). Thus the nozzle forces a higher mass flow rate of air through the turbine. The higher mass flow and higher velocity reduction behind the rotor result in a higher energy output from the wind turbine in the nozzle. In this way the wind turbine efficiency is multiplied. New turbines induce more power from weaker and medium winds and their lasting time, because of the relation p = f(v{sup 3}) (i.e. the power corresponds to wind velocity raised to third power). Wind turbine nozzle produces three times more energy than conventional wind turbine. Short economic analysis for conditions of the island of Lastovo indicates that profit gained by new turbines is up to five times higher than by conventional turbines. The new wind turbine nozzle should generate interest and demand on an international market, even for regions with weaker winds. (Author)

  19. The Process Management in Non - Profit Organisations

    National Research Council Canada - National Science Library

    Dagmara Bubel; Sylwia Legowik-Swiacik; Michal Dziadkiewicz; Anna Wisniewska-Salek

    2016-01-01

      The purpose of this paper is to learn about the implementation of the process management concepts in the non-profit organisations and the possible evaluation of effectiveness raise of the organisations' functioning...

  20. Donations and Differentiation: Three Essays on Non-Profit Strategy

    OpenAIRE

    Wolfolds, Sarah

    2016-01-01

    Given increased competition with for-profit firms, the issue of the comparative advantage of non-profit organizations is renewed. While non-profits may want to differentiate themselves when faced with additional non-profit competition, it is unclear whether they would want to differentiate themselves or converge towards for-profit competitors. This paper addresses this issue by considering the different financing models, human resource systems, and objectives of non-profit organizations, as c...

  1. TRANSPARENCY IN ITALIAN NON PROFIT ORGANIZATIONS

    Directory of Open Access Journals (Sweden)

    Patrizia Gazzola

    2014-07-01

    Full Text Available The aim of the paper is to evaluate the accountability and transparency of Italian non profits organizations. The main goal is to understand if a general accountability or transparency problem, or a systematic publicity deficit, exist in the third sector in Italy. Non profit organizations have an ethical obligation to their stakeholder and to the public to conduct their activities with accountability and transparency. Non profit organizations should regularly and openly convey information to the stakeholder about their vision, mission, objectives, activities, accomplishments, decision-making processes and organizational structure. Information from a non profit organization should be easily accessible to the stakeholder and should create external visibility, public understanding and trust in the organization, conditions necessary to find donors. Non profit organizations work with communities and community donors need to know how their money is used. In the first part the analysis of the definition of transparency and accountability is made and the sustainability report like an important instrument of communication is considered. In the second part an empirical research is presented. The Italian law allows taxpayers to devote 5 per thousand of their income tax to non profit organizations, choosing between charities, social promotion associations, recognized associations, entities dedicated to scientific research and health care, universities, municipal social services and other non profit organizations. The present study present a quantitative research and it’s based on an empirical analysis of non-profit organizations that receive this donation in Italy in the year 2010 and 2011. In the paper we analyze the transparency and the accountability of the top 100 non profit organizations that have received the contribution of 5 per thousand, checking whether they prepare their Sustainability Report or any other kind of report for communicate the use

  2. Tax Evasion, Monopoly, and Nonneutral Profit Taxes

    OpenAIRE

    Lee, Kangoh

    1998-01-01

    It is known in the literature that tax evasion does not influence the monopolist's output decision, and hence, profit taxes are neutral, even in the presence of tax evasion. This result is based on the assumption that the audit probability and the penalty rate are fixed or depend on the understatement or overstatement of relevant economic indicators. However, under alternative and perhaps more reasonable formulations of the audit probability, the neutrality of profit taxes may not be preserve...

  3. Social media and small non profit organisations

    OpenAIRE

    Gulyás, A.

    2016-01-01

    This project sought to explore patterns of and views about social media adoption among small non-profit organisations and to identify mechanisms that could effectively support these organisations with their social media use. \\ud The following findings emerged from the study: \\ud • Social media are now part of the organisational infrastructure of small non-profits and the main ways in which they communicate with the public\\ud • Key variables that influence social media adoption among small non...

  4. Inclusive governance in non-profit organisations

    OpenAIRE

    Borzaga, Carlo; Sacchetti, Silvia

    2015-01-01

    The study of private non-profit enterprises that offer general interest services is only at the start. The understanding of existing organisations resists an inclusive, public interest view of governance. This contribution aims at providing a reflection on specific features that non-profit enterprises should have, and outlines four main justifications for including stakeholders in production governance: 1) access to knowledge and other resources, 2) trust creation, 3) internal efficiency, 4) ...

  5. DETERMINANTS OF BANK PROFITABILITY IN CROATIA

    OpenAIRE

    Ana Kundid; Blanka Škrabić; Roberto Ercegovac

    2011-01-01

    The research objective of this study is twofold. It aims to provide a synthesis of relevant empirical researches on the determinants of commercial banks’ profitability and to establish empirical verification of profitability determinants of banks in the Republic of Croatia using an econometric method of dynamic panel analysis. The empirical analysis is carried out on a data sample of 28 commercial banks in the period 2003-2008 which continuously refers to more than 95 % of assets of the overa...

  6. Determinants of commercial bank profitability in Mexico

    OpenAIRE

    Chavarín, Rubén

    2015-01-01

    The aim of the present work is to identify the main determinants of profitability for commercial banks established in Mexico. A data base of 45 banks representing virtually the whole world of commercial banking in the period 2007-2013 was used. Dynamic models using Arellano-Bover/Blundell-Bond estimators with an error that follows an MA(1) process were employed along with static models having random effects and Hausman-Taylor estimator. Findings suggest that the profitability of commercial ba...

  7. Energy Conflicts and Differential Profits: An Update

    OpenAIRE

    Bichler, Shimshon; Nitzan, Jonathan

    2014-01-01

    During the late 1980s and early 1990s, we identified a new phenomenon that we called ‘energy conflicts’ and showed that these conflicts were intimately linked to the differential profitability of the leading oil companies. This link remains as true today as it was in the early 1970s. Like earlier energy conflicts, the ‘Arab Spring’, the outsourced wars that followed and the third Gulf War against ISIS continue to march to the drum beat of differential profits.

  8. Fractal profit landscape of the stock market.

    Science.gov (United States)

    Grönlund, Andreas; Yi, Il Gu; Kim, Beom Jun

    2012-01-01

    We investigate the structure of the profit landscape obtained from the most basic, fluctuation based, trading strategy applied for the daily stock price data. The strategy is parameterized by only two variables, p and q Stocks are sold and bought if the log return is bigger than p and less than -q, respectively. Repetition of this simple strategy for a long time gives the profit defined in the underlying two-dimensional parameter space of p and q. It is revealed that the local maxima in the profit landscape are spread in the form of a fractal structure. The fractal structure implies that successful strategies are not localized to any region of the profit landscape and are neither spaced evenly throughout the profit landscape, which makes the optimization notoriously hard and hypersensitive for partial or limited information. The concrete implication of this property is demonstrated by showing that optimization of one stock for future values or other stocks renders worse profit than a strategy that ignores fluctuations, i.e., a long-term buy-and-hold strategy.

  9. TURKISH BANKING SECTOR’S PROFITABILITY FACTORS

    Directory of Open Access Journals (Sweden)

    Songül Kakilli ACARAVCI

    2013-01-01

    Full Text Available Profitability of banking sector is the most important instrument of financial system for the future of the economy. The objective of this study is to determine by using Johansen and Juselius cointegration test approach of the bank specific and macroeconomic factors that affect the profitability of commercial banks in Turkish banking sector. In study, the data are collected from the three biggest state-owned, privately-owned and foreign banks. The sample period spans from 1998 to 2011. In the study, return of asset, return of equity and net interest margin were used as proxy for profitability of banks. The bank specific determinants, which were thought to have effects on profitability are total credits/total assets, total deposits/total assets, total liquid assets/total assets, total wage and commission incomes/ total assets, total wage and commission expenses/total assets, the logarithm of total assets and total equity/total assets. The macroeconomic determinants of study are real gross domestic product, inflation rate, real exchange rate and real interest rate. Empirical findings suggest that the bank specific determinants have been more effect than macroeconomic factors on profitability of the banks. The reel gross domestic product and real exchange rate have been effective on the profitability. In addition, the 2001 economic crisis has a negative effect on all Turkish Banking sector.

  10. Profits in reverse? An examination of the decisive factors for reverse supply chain profitability

    DEFF Research Database (Denmark)

    Larsen, Samuel; Jacobsen, Peter

    2015-01-01

    Although the concept of the reverse supply chain (RSC) is not unknown in industry, an inhibitor for its successful use is low (or no) profitability. A research challenge is investigating ways to establish the RSC as a profit-creating center in the organization. This paper contributes to this chal......Although the concept of the reverse supply chain (RSC) is not unknown in industry, an inhibitor for its successful use is low (or no) profitability. A research challenge is investigating ways to establish the RSC as a profit-creating center in the organization. This paper contributes...

  11. Contrasting Socio-Economic and Demographic Profiles of Two, Small Island, Economic Species: MIRAB versus PROFIT/SITE

    Directory of Open Access Journals (Sweden)

    Ashley Oberst

    2007-11-01

    Full Text Available The MIRAB model developed by Bertram and Watters, based on remittances and aid, has dominated the small island economy literature for two decades. Recently, two challenges have surfaced: the PROFIT formulation emphasizing domestic policy flexibility - a so-called ‘resourcefulness of jurisdiction’ - and a dynamic private sector (Baldacchino, 2006; and the SITE model, stressing the role of tourism (McElroy, 2006. To date, there has been no comparative assessment of these different island models. This article addresses this gap. Its point of departure is to consider SITE islands as a subspecies of the PROFIT cluster. It constructs comprehensive profiles across 27 socio-economic and demographic variables for two island sub-groups with populations of less than three million: 23 MIRAB and 35 PROFIT-SITE. Results indicate PROFIT-SITE islands are much more affluent, socially advanced and demographically mature than their MIRAB counterparts.

  12. ORGANIZATIONAL PROJECT MANAGEMENT MATURITY

    Directory of Open Access Journals (Sweden)

    Yana Derenskaya

    2017-11-01

    Full Text Available The present article is aimed at developing a set of recommendations for achieving a higher level of organizational project maturity at a given enterprise. Methodology. For the purposes of the current research, the available information sources on the components of project management system are analysed; the essence of “organizational maturity” and the existing models of organizational maturity are studied. The method of systemic and structural analysis, as well as the method of logical generalization, are employed in order to study the existing models of organizational maturity, to describe levels of organizational maturity, and finally to develop a set of methodological recommendations for achieving a higher level of organizational project maturity at a given enterprise. The results of the research showed that the core elements of project management system are methodological, organizational, programtechnical, and motivational components. Project management encompasses a wide range of issues connected with organizational structure, project team, communication management, project participants, etc. However, the fundamental basis for developing project management concept within a given enterprise starts with defining its level of organizational maturity. The present paper describes various models of organizational maturity (staged, continuous, petal-shaped and their common types (H. Кеrzner Organizational Maturity Model, Berkeley PM Maturity Model, Organizational Project Management Maturity Model, Portfolio, Program & Project Management Maturity Model. The analysis of available theoretic works showed that the notion “organizational project maturity” refers to the capability of an enterprise to select projects and manage them with the intention of achieving its strategic goals in the most effective way. Importantly, the level of maturity can be improved by means of formalizing the acquired knowledge, regulating project-related activities

  13. PROFIT: Bayesian profile fitting of galaxy images

    Science.gov (United States)

    Robotham, A. S. G.; Taranu, D. S.; Tobar, R.; Moffett, A.; Driver, S. P.

    2017-04-01

    We present PROFIT, a new code for Bayesian two-dimensional photometric galaxy profile modelling. PROFIT consists of a low-level C++ library (libprofit), accessible via a command-line interface and documented API, along with high-level R (PROFIT) and PYTHON (PyProFit) interfaces (available at github.com/ICRAR/libprofit, github.com/ICRAR/ProFit, and github.com/ICRAR/pyprofit, respectively). R PROFIT is also available pre-built from CRAN; however, this version will be slightly behind the latest GitHub version. libprofit offers fast and accurate two-dimensional integration for a useful number of profiles, including Sérsic, Core-Sérsic, broken-exponential, Ferrer, Moffat, empirical King, point-source, and sky, with a simple mechanism for adding new profiles. We show detailed comparisons between libprofit and GALFIT. libprofit is both faster and more accurate than GALFIT at integrating the ubiquitous Sérsic profile for the most common values of the Sérsic index n (0.5 automated bulge-disc decomposition with PROFIT on SDSS, KiDS, and future LSST imaging. We find that the biggest increases in fit quality come from moving from SDSS- to KiDS-quality data, with less significant gains moving from KiDS to LSST.

  14. 48 CFR 1615.404-70 - Profit analysis factors.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Profit analysis factors... CONTRACTING BY NEGOTIATION Contract Pricing 1615.404-70 Profit analysis factors. (a) OPM contracting officers..., will likely serve to diminish this profit analysis factor in an overall determination of profit. This...

  15. Novel Reading Maturity Scale.

    Science.gov (United States)

    Reich, Carol

    Designed to assess the maturity level of the novels which students read, the Novel Reading Maturity Scale (NRMS) is based on the notion that fiction of high quality is characterized by a number of themes or topics. The list of 22 topics in NRMS came from a survey of several guides on books for teenagers. To explore the reliability of the scale,…

  16. DETERMINANTS OF BANK PROFITABILITY IN CROATIA

    Directory of Open Access Journals (Sweden)

    Ana Kundid

    2011-02-01

    Full Text Available The research objective of this study is twofold. It aims to provide a synthesis of relevant empirical researches on the determinants of commercial banks’ profitability and to establish empirical verification of profitability determinants of banks in the Republic of Croatia using an econometric method of dynamic panel analysis. The empirical analysis is carried out on a data sample of 28 commercial banks in the period 2003-2008 which continuously refers to more than 95 % of assets of the overall banking intermediation. Return on assets (ROA is profitability indicator used in the analysis. The presented research results and their economic interpretation may serve as a valuable foundation for the general assessment of commercial bank management in Croatia as well as for identifying several sources of potential improvement and impairment of their financial performance in the future. Thus, corrective actions could be planned and implemented in advance.

  17. IMPROVEMENTS IN ACCOUNTING OF BREWERIES’ PROFIT

    Directory of Open Access Journals (Sweden)

    I. Sklyaruk

    2013-11-01

    Full Text Available The peculiarities of formation of the profit of breweries, taking into account the specifics of the production process and business peculiarities were identified. There were found out the specificity of calculation of the expenses, considering the norms of the technological process, the duration of the operating cycle and the specifics of the production of beer and non-alcoholic products, which determine the methodology of formation of the prime price of the products and the price of its sale. The expediency of using the method for phases (with semi-ready and not semi- ready option method of calculation of the semi-finished products of own production there was proved. The irrelevance of using Account 44 “Undistributed profit (uncovered loss” according to its purpose under the current Plan of accounts is shown. The model of using the profit based on the proposed sub-accounts was built and the example of their use was shown.

  18. Democracy and non-profit housing

    DEFF Research Database (Denmark)

    Hansen, Anne Vorre; Langergaard, Luise Li

    2017-01-01

    Resident democracy as a special form of participatory democratic set-up is fundamental in the understanding, and self-understanding, of the non-profit housing sector in Denmark. Through a case study, the paper explores how resident democracy is perceived and narrated between residents and employees...... at a housing association. The study indicates that the meta-story of democracy is disconnected from practice and the lived lives of residents. Three analytical tensions structure the analysis, which relate to the conditions for realizing the democratic ideal embedded in the structure of the sector......, the article discusses conditions for prospective democracy in the Danish non-profit housing sector....

  19. Management trends: Internationalization of non-profit organizations

    Directory of Open Access Journals (Sweden)

    Inić Branimir P.

    2015-01-01

    Full Text Available Non-profit organizations are increasingly gaining importance in the modern economy with their development and their numbers increasing day by day. It is very important to note that non-profit organizations are often subject to various benefits that the for-profit companies are not. Thus, for example, preferential tax status of non-profit organizations is manifested primarily in the form of exemption from corporate income tax. In addition, private non-profit organizations enjoy various other state, local and federal taxes exemptions. Under certain conditions, these organizations are exempt from taxes on donations and membership fees. A feature that differentiates various non-profit organizations and profit-oriented companies is their source of income. Profit oriented companies depend on their income, obtained from sales of their goods or services to customers, who usually cover the price and cost of goods and services plus the profit. In contrast, nonprofit organizations are very dependent on membership fees, tax exemptions, members donations or depend on funds of the sponsoring agency which covers most of their costs, for example a federal government agency. Those non-profit organizations that have substantial operating costs beyond national borders and do not identify themselves as purely domestic in their mandate are International non-profit organizations. Most non-profit organizations remain in their national boundaries, on the territory of the country in which they were created, but a large number of non-profit organizations rapidly internationalize, and some larger non-profits have grown into important global actors. The paper includes the following sections: (1 introduction, (2 why is the 'non-profit' important, (3 the internationalization of non-profit organizations, (4 sources of income of non-profit organizations (4.1. causality of impact and of strategic decisions in cases pertaining to universities, (5 the limits of strategic

  20. 48 CFR 415.404-4 - Profit.

    Science.gov (United States)

    2010-10-01

    ...) Termination settlements; and (v) Cost-plus-award-fee contracts; (b) Unless otherwise restricted by contracting... CONTRACT TYPES CONTRACTING BY NEGOTIATION Contract Pricing 415.404-4 Profit. (a)(1) USDA will use a... negotiation is based on cost analysis. (2) The following types of acquisitions are exempt from the...

  1. 48 CFR 215.404-4 - Profit.

    Science.gov (United States)

    2010-10-01

    ... prenegotiation profit or fee objective on any negotiated contract action when cost or pricing data is obtained, except for cost-plus-award-fee contracts (see 215.404-74, 216.405-2, and FAR 16.405-2) or contracts with... DEFENSE CONTRACTING METHODS AND CONTRACT TYPES CONTRACTING BY NEGOTIATION Contract Pricing 215.404-4...

  2. 262 257 Profitability Analysis of Three Met

    African Journals Online (AJOL)

    2008-12-02

    Dec 2, 2008 ... Profitability Analysis of Three Methods of Suya Production and Marketing in. Maiduguri metropolitan Council, Borno State, ... N 1.25:1 and N 1.1:1 for Kilishi, Tsire and Balangu production and marketing enterprises, respectively. The marketing ... packaging and retailing. It is retailed to consumers in cement ...

  3. Profitability analysis and management practices among poultry ...

    African Journals Online (AJOL)

    Profitability analysis and management practices among poultry farmers in Yola metropolis of Adamawa state, Nigeria. ... Global Journal of Agricultural Sciences ... The major constraints includes: high input costs, unstable market, power supply, diseases, loans, government assistance and to lack of poultry management ...

  4. Profitability of Qualified-Labour-Power Production

    Science.gov (United States)

    Baldino, Roberto Ribeiro; Cabral, Tânia Cristina Baptista

    2015-01-01

    In Baldino and Cabral (2013) we introduced the concept of qualified labour-power as the commodity produced by the school system. In the present article we outline a quantitative model to evaluate the profit rate of educational programmes. We compare a medical school programme with a teacher education programme at a public university in Brazil,…

  5. EPA for Businesses and Non-Profits

    Science.gov (United States)

    Information and links to EPA web pages that are meant to help businesses and non-profits adhere to EPA regulations and otherwise protect the environment, take advantage of opportunities to collaborate with the EPA, and find training EPA training programs.

  6. Continuous sawmill studies: protocols, practices, and profits

    Science.gov (United States)

    Robert Mayer; Jan Wiedenbeck

    2005-01-01

    In today's global economy, the "opportunity cost" associated with suboptimal utilization of raw material and mill resources is significant. As a result, understanding the profit potential associated with different types of logs is critically important for sawmill survival. The conventional sawmill study typically has been conducted on a substantially...

  7. How to Generate Good Profit Maximization Problems

    Science.gov (United States)

    Davis, Lewis

    2014-01-01

    In this article, the author considers the merits of two classes of profit maximization problems: those involving perfectly competitive firms with quadratic and cubic cost functions. While relatively easy to develop and solve, problems based on quadratic cost functions are too simple to address a number of important issues, such as the use of…

  8. THE PERFORMANCE AND PROFITABILITY OF SWEET POTATO ...

    African Journals Online (AJOL)

    propagule length and cattle dung application rates on the growth, yield and profitability of sweet potato. (Ipomea batatas L.) in a humid Ultisols. ... this permits the growing of two or three crop cycles in a year. This crop is usually produced ...... vegetative growth as evidenced by number of leaves, vines, shorter internodes and ...

  9. Data Sparseness and Variance in Accounting Profitability

    NARCIS (Netherlands)

    S. Stavropoulos (Spyridon); M.J. Burger (Martijn); D. Skuras (Dimitris)

    2015-01-01

    markdownabstract__Abstract__ A central question in strategic management is why some firms perform better than others. One approach to addressing this question empirically is to decompose the variance in firm-level profitability into firm, industry, location, and year components. Although it is

  10. Cooperation and profit allocation in distribution chains

    NARCIS (Netherlands)

    Guardiola, L.A.; Meca, A.; Timmer, Judith B.

    2005-01-01

    We study the coordination of actions and the allocation of profit in distribution chains under decentralized control. We consider distribution chains in which a single supplier supplies goods for replenishment of stocks of several retailers who, in turn, sell these goods to their own separate

  11. Profitability Analysis of Groundnuts Processing in Maiduguri ...

    African Journals Online (AJOL)

    This paper examines the profitability of groundnuts processing in Maiduguri Metropolitan Council of Borno State. The specific objectives of the study were to examine the socioeconomic characteristics of groundnut processors, estimate the costs and returns in groundnut processing and determine the return on investment in ...

  12. Salmonella infects B cells by macropinocytosis and formation of spacious phagosomes but does not induce pyroptosis in favor of its survival.

    Science.gov (United States)

    Rosales-Reyes, Roberto; Pérez-López, Araceli; Sánchez-Gómez, Concepción; Hernández-Mote, Rosaura Ruth; Castro-Eguiluz, Denisse; Ortiz-Navarrete, Vianney; Alpuche-Aranda, Celia Mercedes

    2012-06-01

    We have previously reported that Salmonella infects B cells and survives within endosomal-lysosomal compartments. However, the mechanisms used by Salmonella to enter B cells remain unknown. In this study, we have shown that Salmonella induces its own entry by the induction of localized ruffling, macropinocytosis, and spacious phagosome formation. These events were associated with the rearrangement of actin and microtubule networks. The Salmonella pathogenesis island 1 (SPI-1) was necessary to invade B cells. In contrast to macrophages, B cells were highly resistant to cell death induced by Salmonella. These data demonstrate the ability of Salmonella to infect these non-professional phagocytic cells, where the bacterium can find an ideal intracellular niche to support persistence and the possible dissemination of infection. Copyright © 2012 Elsevier Ltd. All rights reserved.

  13. Tumor-Derived Microvesicles Modulate Antigen Cross-Processing via Reactive Oxygen Species-Mediated Alkalinization of Phagosomal Compartment in Dendritic Cells

    Directory of Open Access Journals (Sweden)

    Federico Battisti

    2017-09-01

    Full Text Available Dendritic cells (DCs are the only antigen-presenting cells able to prime naïve T cells and cross-prime antigen-specific CD8+ T cells. Their functionality is a requirement for the induction and maintenance of long-lasting cancer immunity. Albeit intensively investigated, the in vivo mechanisms underlying efficient antigen cross-processing and presentation are not fully understood. Several pieces of evidence indicate that antigen transfer to DCs mediated by microvesicles (MVs enhances antigen immunogenicity. This mechanism is also relevant for cross-presentation of those tumor-associated glycoproteins such as MUC1 that are blocked in HLA class II compartment when internalized by DCs as soluble molecules. Here, we present pieces of evidence that the internalization of tumor-derived MVs modulates antigen-processing machinery of DCs. Employing MVs derived from ovarian cancer ascites fluid and established tumor cell lines, we show that MV uptake modifies DC phagosomal microenvironment, triggering reactive oxygen species (ROS accumulation and early alkalinization. Indeed, tumor MVs carry radical species and the MV uptake by DCs counteracts the chemically mediated acidification of the phagosomal compartment. Further pieces of evidence suggest that efficacious antigen cross-priming of the MUC1 antigen carried by the tumor MVs results from the early signaling induced by MV internalization and the function of the antigen-processing machinery of DCs. These results strongly support the hypothesis that tumor-derived MVs impact antigen immunogenicity by tuning the antigen-processing machinery of DCs, besides being carrier of tumor antigens. Furthermore, these findings have important implications for the exploitation of MVs as antigenic cell-free immunogen for DC-based therapeutic strategies.

  14. Alternative profit rate shariah-compliant for islamic banking

    Science.gov (United States)

    Gazali, Nadhirah; Halim, Nurfadhlina Abdul; Ghazali, Puspa Liza

    2017-09-01

    Profit is the aims for Islamic banking and conventional banking. Determination of profit in Islamic banking in Malaysia depends on the profit rate, whereas profit rate is essentially from reference rate which is known as the base rate (BR). However, the determination of the components contained in the BR such as benchmark cost of funds and the statutory reserve requirement (SRR) is non-compliance with the Shariah because its directly proportional to the overnight policy rate (OPR). Therefore, an alternative formula for the profit rate are proposed which is known as the base profit rate (BPR). Construction of BPR formula is based on the principle that are more Shariah-compliant.

  15. Modulation of phagolysosome maturation by bacterial tlyA gene ...

    Indian Academy of Sciences (India)

    2014-10-20

    Oct 20, 2014 ... 85% of both non-TlyA-expressing E. coli and M. smegmatis. (E. coli/pET28a+ and M. smegmatis/pMyNT) are positive for the LysoTracker staining (figure 2B and D). This is consistent with previous report that only 26% of live BCG phagosomes were LysoTracker-positive compared to 62% of phagosomes.

  16. Profitability and Efficiency of Red Onion Farming

    Directory of Open Access Journals (Sweden)

    Imron Rosyadi

    2014-12-01

    Full Text Available The purpose of this research is to determine and analyze the profitability and performance of onion farming marketing margins; analyze and know the parts of prices received by farmers and analyze the efficiency of onion farming in the district of Brebes. Samples taken in this study is 30 onion farmers in the district of Brebes, who settled in six villages, each village was taken 5 farmers as the research sample. These results indicate that the location of onion farming research does not provide benefits significantly to the household economy of farmers. Higher selling prices at the retail level and supermarkets do not have a significant impact on the level of profits of farming in the study area. Farming is done by farmers in the study area is inefficient. Onion marketing chain in the study area is relatively long, which consists of 4 lines of marketing.

  17. Competition and Profitability in European Financial Services

    DEFF Research Database (Denmark)

    Balling, Morten; Lierman, F.; Mullineux, A.

    Financial services firms play a key role in the European economy. The efficiency and profitability of these firms and the competition among them have an impact on allocation of savings, financing of investment, economic growth, the stability of the financial system and the transmission of monetary...... policy. This collection of research contributions includes evaluations of trends in the European financial service industry and examinations of the driving forces of efficiency, competition and profitability of financial firms and institutions in Europe. The papers have been written by leading academics...... and researchers in the field, who specialize in strategic, systematic and policy issues related to the European financial services industry. This edited collection will be will be essential reading for students and academics but will also be of interest to financial practitioners and government officials...

  18. Competition for FDI and Profit Shifting

    DEFF Research Database (Denmark)

    Ma, Jie; Raimondos-Møller, Pascalis

    When countries compete for the location of a new multinational plant they need to be aware of the profit shifting opportunities this new plant creates for the global multinational firm. By modelling explicitly the multinational’s intra-firm transactions, we show that the home market advantage tha...... easily win the location game ahead of a large country. How lenient the small country is in implementing transfer pricing regulations turns out to be an important variable in such location games....

  19. Profitability and Efficiency of Red Onion Farming

    OpenAIRE

    Rosyadi, Imron; Purnomo, Didit

    2014-01-01

    The purpose of this research is to determine and analyze the profitability and performance of onion farming marketing margins; analyze and know the parts of prices received by farmers and analyze the efficiency of onion farming in the district of Brebes. Samples taken in this study is 30 onion farmers in the district of Brebes, who settled in six villages, each village was taken 5 farmers as the research sample. These results indicate that the location of onion farming research does not provi...

  20. Base Erosion, Profit Shifting and Developing Countries

    OpenAIRE

    Ernesto Crivelli; De Mooij, Ruud A.; Michael Keen

    2015-01-01

    International corporate tax issues are prominent in public debate, notably with the G20-OECD project addressing Base Erosion and Profit Shifting (‘BEPS’). But while there is considerable empirical evidence for advanced countries on the cross-country fiscal externalities at the heart of these issues, there is almost none for developing countries. This paper uses panel data for 173 countries over 33 years to explore their magnitude and nature, focusing particularly on developing countries a...

  1. Determinants of Bank Profitability in Nigeria

    OpenAIRE

    Osuagwu, Eze

    2014-01-01

    There are increasing scholarly debates on the direction of policy to effectively improve the performance of banks. Some scholars argue that bank performance is enhanced by improvements in the internal organization and managerial efficiency, others argue that industry wide factors are integral to bank performance. In recent times, the direction of literature has shown that macroeconomic factors play a significant role in determining bank profitability. This paper investigates the determinants ...

  2. The Determinants Of European Bank Profitability

    OpenAIRE

    Christos K. Staikouras; Wood, Geoffrey E.

    2011-01-01

    The rate of return earned by a financial institution is affected by numerous factors. These factors include elements internal to each financial institution and several important external forces shaping earnings performance. The type of explanation would determine possible policy implications and ought to be taken seriously. This paper reviews the literature on bank performance studies and classifies the bank profitability determinants. The second part of the paper quantifies how internal dete...

  3. Business strategies, profitability and efficiency of production

    OpenAIRE

    S. Alarcón; M. Sánchez

    2013-01-01

    The strategy choices of market-oriented companies are a topic now under wide investigation in the analysis of business performance antecedents. The purpose of this study is to examine the outcomes of the combination of three different organizational strategies (market orientation, innovativeness and entrepreneurial orientation) on business performance indicators. Models using profitability and efficiency indicators are proposed with the specific aim of obtaining a deeper analysis of the relat...

  4. Profitability of Management Systems on German Fenlands

    Directory of Open Access Journals (Sweden)

    Marco Rebhann

    2016-10-01

    Full Text Available Fens are organic sites that require drainage for agricultural use. Lowering the groundwater level leads to trade-offs between economic benefits and environmental impacts (i.e., CO2 and nutrient emissions. To identify management options that are both environmentally and economically sustainable, a propaedeutic systematic analysis of the costs, income and profit of different land use and management systems on fenlands is necessary. This study provides an overview of the profitability, labor demand and comparative advantages of feasible management systems on German fenlands. Twenty management practices in four land use systems are analyzed. The results indicate that most management systems are profitable only with subsidies and payments for ecosystem services. In addition to sales revenue, these payments are indispensable to promote peat-saving agricultural practices on fenlands. Regarding the labor aspect, intensive management systems caused an increase in working hours per hectare, which may positively affect employment in rural areas. The calculations obtained in this study can be used as a basis for estimations of greenhouse gas (GHG mitigation costs when management systems are associated with GHG emission values.

  5. Profit-Sharing – A Tool for Improving Productivity, Profitability and Competitiveness of Firms?

    Directory of Open Access Journals (Sweden)

    Fibirova Jana

    2013-12-01

    Full Text Available The importance of appropriate utilization of rewards for performance is still growing and therefore this type of rewards can be seen as a significant part of a total rewards package. Companies that are able to appropriately implement rewards for performance may gain competitive advantage over their competitors, but successful implementation requires a good knowledge of these rewards. The main aim of this paper is to contribute to the growth of this knowledge by identifying possible positive and negative impacts of profit-sharing on various areas that are important for the performance of a company, nevertheless, addressed are also macroeconomic consequences of profit-sharing. Furthermore, a comprehensive and up-to-date review of the relevant literature is provided, under-researched areas are identified and suggestions for further research are given. To accomplish these goals, we applied methods of bibliometric analysis to the articles indexed in ISI Web of Knowledge to identify the most important articles, authors and topics. According to our findings, the majority of studies report a neutral or positive impact of profit-sharing on productivity and profitability. This impact may be achieved by direct influence of profit-sharing on productivity of employees (due to the dependence of their pay on profit, but it seems that yet more important are various mediating mechanisms, especially effects on employment stability, absenteeism, quits and related issues, as well as effects on attitudes of employees and on relationships between employees. We argue that a well-designed profit-sharing plan is crucial for its success, but it is a relatively under-researched problem.

  6. 26 CFR 1.1502-33 - Earnings and profits.

    Science.gov (United States)

    2010-04-01

    ... also lost in Year 1, P would have decreased its earnings and profits for Year 1 by the additional $50... 26 Internal Revenue 12 2010-04-01 2010-04-01 false Earnings and profits. 1.1502-33 Section 1.1502... (CONTINUED) INCOME TAXES Basis, Stock Ownership, and Earnings and Profits Rules § 1.1502-33 Earnings and...

  7. Relating customer satisfaction to customer profitability: an empirical ...

    African Journals Online (AJOL)

    This paper explores relationships between customer satisfactions; repurchase intentions, purchase behavior, and customer profitability with empirical data on attitudes, behavior, and profitability at the customer level of analysis. Purchase behavior and profitability data derived from the accounting system of a firm, are ...

  8. Comparative Corporate Governance of Non-Profit Organizations

    DEFF Research Database (Denmark)

    Thomsen, Steen

    2014-01-01

    Based on the impressive work of Hopt and von Hippel (2010), I review the comparative corporate governance of non-profit organizations and propose topics for future research. There is evidence of agency problems in non-profit as well as for-profit organizations, but the governance mechanisms...

  9. 26 CFR 1.312-6 - Earnings and profits.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 4 2010-04-01 2010-04-01 false Earnings and profits. 1.312-6 Section 1.312-6...) INCOME TAXES Effects on Corporation § 1.312-6 Earnings and profits. (a) In determining the amount of earnings and profits (whether of the taxable year, or accumulated since February 28, 1913, or accumulated...

  10. An Algorithm for the Nucleolus of Airport Profit Problems

    NARCIS (Netherlands)

    Brânzei, R.; Inarra, E.; Tijs, S.H.; Zarzuelo, J.

    2003-01-01

    Airport profit games are a generalization of airport cost games as well as of bankruptcy games.In this paper we present a simple algorithm to compute the nucleolus of airport profit games.In addition we prove that there exists an unique consistent allocation rule in airport profit problems, and it

  11. Taxing across Borders: Tracking Personal Wealth and Corporate Profits

    National Research Council Canada - National Science Library

    Gabriel Zucman

    2014-01-01

    ... that UScompanies are shifting profits to Bermuda, Luxembourg, and similar countries on a large and growing scale. About 20percent of all US corporate profits are now booked in such havens, a tenfoldincrease since the 1980s. This profit-shifting is typically done within the letter of the law and thus would be best described as tax avoidance rather than fraud. ...

  12. Determinants Of Profitability And Willingness To Pay For ...

    African Journals Online (AJOL)

    The study attempts to analyse the profitability of urban agriculture using metropolitan organic waste in Abuja, the Federal Capital Territory of Nigeria. The results show that the enterprise is profitable, and that output price is the most important determinant of maximum variable profit. Other price factors, specifically planting ...

  13. LAMP proteins account for the maturation delay during the establishment of the Coxiella burnetii-containing vacuole.

    Science.gov (United States)

    Schulze-Luehrmann, Jan; Eckart, Rita A; Ölke, Martha; Saftig, Paul; Liebler-Tenorio, Elisabeth; Lührmann, Anja

    2016-02-01

    The obligate intracellular pathogen Coxiella burnetii replicates in a large phagolysosomal-like vacuole. Currently, both host and bacterial factors required for creating this replicative parasitophorous C. burnetii-containing vacuole (PV) are poorly defined. Here, we assessed the contributions of the most abundant proteins of the lysosomal membrane, LAMP-1 and LAMP-2, to the establishment and maintenance of the PV. Whereas these proteins were not critical for uptake of C. burnetii, they influenced the intracellular replication of C. burnetii. In LAMP-1/2 double-deficient fibroblasts as well as in LAMP-1/2 knock-down cells, C. burnetii establishes a significantly smaller, yet faster maturing vacuole, which harboured more bacteria. The accelerated maturation of PVs in LAMP double-deficient fibroblasts, which was partially or fully reversed by ectopic expression of LAMP-1 or LAMP-2, respectively, was characterized by an increased fusion rate with endosomes, lysosomes and bead-containing phagosomes, but not by different fusion kinetics with autophagy vesicles. These findings establish that LAMP proteins are critical for the maturation delay of PVs. Unexpectedly, neither the creation of the spacious vacuole nor the delay in maturation was found to be prerequisites for the intracellular replication of C. burnetii. © 2015 John Wiley & Sons Ltd.

  14. Economic value of female fertility and its relationship with profit in Spanish dairy cattle.

    Science.gov (United States)

    González-Recio, O; Pérez-Cabal, M A; Alenda, R

    2004-09-01

    A data file of 225,085 inseminations and 120,713 lactations from 63,160 Holstein cows was analyzed to obtain female fertility economic value according to number of inseminations per service period (INS). Fertility cost (FCOST) was included in a bioeconomic model, taking into account number of doses of semen, hormonal treatments, fertility culling cost, and delayed milk and calf sales. A profit equation was elaborated to estimate fertility cost and profit according to INS. Fertility in Spanish dairy cattle has worsened >10% over the last 14 yr. Days open have increased by about 15 d, and INS has increased from 1.7 to 2.0. A quadratic relationship was found between FCOST and INS. Similar profitability was estimated for cows who needed one or 2 INS, but when >3 INS were needed, profit decreased by >205 (US dollars)/yr per cow. Cows that needed more INS had higher milk yield per lactation, but also had a higher culling risk and lower productive life and lifetime production, therefore, lower profit. Calving interval (CI) and INS economic values were, respectively, -4.90 and -67.32 (US dollars)/yr per cow and per one unit of change. The economic values of productive traits were 4.04, 1.02, and 1.19 (US dollars)/yr per cow and per one unit of change for kg protein, kg fat, and days in milk, respectively. A mature body weight economic value of -0.67 (US dollars)/yr per cow and per kg was estimated. The relative importance of fertility traits with respect to protein was 64% for CI and 24% for INS, although the CI economic value is highly influenced by phenotypic standard deviation considered.

  15. Maturing interorganisational information systems

    NARCIS (Netherlands)

    Plomp, M.G.A.

    2012-01-01

    This thesis consists of nine chapters, divided over five parts. PART I is an introduction and the last part contains the conclusions. The remaining, intermediate parts are: PART II: Developing a maturity model for chain digitisation. This part contains two related studies concerning the development

  16. Mechanics of bacteriophage maturation

    NARCIS (Netherlands)

    Roos, Wouter H.; Gertsman, Ilya; May, Eric R.; Brooks III, Charles L.; Johnson, John E.; Wuite, Gijs J. L.

    2012-01-01

    Capsid maturation with large-scale subunit reorganization occurs in virtually all viruses that use a motor to package nucleic acid into preformed particles. A variety of ensemble studies indicate that the particles gain greater stability during this process, however, it is unknown which material

  17. Organizational Structure and Behaviour in Day Care: Differences between Non-Profit and For-Profit Centres.

    Science.gov (United States)

    Canning, Patricia M.; Lyon, Mary E.; Kienapple, Kim; Young, Jeffrey

    2002-01-01

    Examined how Canadian day care centers are operated and managed, to identify differences in organizational structure and behavior between non-profit and for-profit centers and characteristics of structure and management linked with high quality care. Found that non-profit centers were more complex, more formalized, and less centralized than…

  18. DOD Contractor Profitability 1980-1984

    Science.gov (United States)

    1985-12-01

    compdny’s control), surf)lus, and retdined earnings. 2. Seleccion of a Profit ~~asure A number of prot1t measures have been used in s t u d y i n g de E...iC- GGG GGG GGG L"II .:)S. 0.. S.t?ACr; F1ŕC COHPOkA’l’ I ON 1. ~1C Corp. is the world’s largest ~roducer of natural sod~ ash and

  19. Stream maintenance as a profit center

    Energy Technology Data Exchange (ETDEWEB)

    Bouchillon, J.L.

    1997-06-01

    Probably one of the most overlooked profit centers in industrial management strategy is savings in energy costs. Every $1 in certified energy savings is often worth over $10 in increased sales. The author has found from actual practice that there is big corporate profit in a shrewd, diligent steam trap management program. He describes a way to restructure corporate handling of trap maintenance to turn it into a source of revenue. Cited is a case history of building an intensive trap maintenance program at a large, 4000 trap chemical plant. The previously {open_quotes}good{close_quotes} maintenance program which was losing $565,000 per year in steam was turned into a $485,000 per year cost savings. This article will also give the steps that can in as few as 3 months generate over $125,000 annually in tax-free cash per 1000 traps with an investment payback of 18 months or less. The author is a businessman and energy management consultant that has no trap sales or promotion.

  20. Business strategies, profitability and efficiency of production

    Directory of Open Access Journals (Sweden)

    S. Alarcón

    2013-02-01

    Full Text Available The strategy choices of market-oriented companies are a topic now under wide investigation in the analysis of business performance antecedents. The purpose of this study is to examine the outcomes of the combination of three different organizational strategies (market orientation, innovativeness and entrepreneurial orientation on business performance indicators. Models using profitability and efficiency indicators are proposed with the specific aim of obtaining a deeper analysis of the relative roles played by each. The empirical work takes place in the agro-food industry in the Ebro Valley, one of Spain’s most competitive regions. The estimates from profitability quantile and truncated regressions of the efficiency scores reveal that market orientation has a positive effect on economic and productivity performance. The impact of pro-active, innovation-seeking, and risk-averse entrepreneurship is nevertheless more debatable, despite some influence of these entrepreneurial styles on observed performance values. This enables conclusions regarding the possibility of combining a market-oriented business culture with innovation and entrepreneurial activity with a view to obtaining business performance gains.

  1. Delayed visual maturation.

    OpenAIRE

    Cole, G F; Hungerford, J.; Jones, R B

    1984-01-01

    Sixteen blind babies who were considered to be showing the characteristics of delayed visual maturation were studied prospectively. The diagnosis was made on clinical grounds, and the criteria for this are discussed. All of these infants developed visual responses between 4 and 6 months of age and had normal or near normal visual acuities by 1 year of age. Long term follow up, however, has shown neurological abnormalities in some of these children.

  2. Delayed visual maturation.

    Science.gov (United States)

    Fielder, A R; Russell-Eggitt, I R; Dodd, K L; Mellor, D H

    1985-01-01

    Fifty-three infants with delayed visual maturation (DVM) are presented. These have been classified according to their ocular and systemic features into three groups: DVM as an isolated anomaly, in association with mental retardation, and ocular abnormalities accompanied by DVM. The clinical features are discussed, particularly regarding the time and speed of visual improvement in the three groups. Infants with DVM who experienced difficulties in the perinatal period have an increased risk of developing permanent neurological sequelae.

  3. Cournot competition between a non-profit firm and a for-profit firm with uncertainty

    Science.gov (United States)

    Ferreira, Fernanda A.

    2010-03-01

    In this paper, we consider a Cournot competition between a nonprofit firm and a for-profit firm in a homogeneous goods market, with uncertain demand. Given an asymmetric tax schedule, we compute explicitly the Bayesian-Nash equilibrium. Furthermore, we analyze the effects of the tax rate and the degree of altruistic preference on market equilibrium outcomes.

  4. To Profit or Not To Profit: That Is the Tough Question.

    Science.gov (United States)

    Neugebauer, Roger

    1999-01-01

    Discusses advantages and disadvantages of organizing a child care operation as a for-profit or a nonprofit organization. Areas discussed include ease of start up; access to capital and funding; exposure to taxes; access to community support; appeal to volunteers, teaching candidates, and parents; challenge of management; risk to management;…

  5. Do non-profits make a difference? : Evaluating non-profit vis-à-vis for-profit organisations in social

    NARCIS (Netherlands)

    Koning, P.; Noailly, J.; Visser, S.

    2006-01-01

    This CPB Document provides a framework for the evaluation of non-profit organisations. This framework addresses the question under which conditions, and, if so, in what way non-profits should be stimulated. Essentially, in order to answer these questions, three steps can be followed: (i) identifying

  6. Determinants of profitability differences among major refiner/marketers

    Energy Technology Data Exchange (ETDEWEB)

    1985-01-01

    This report attempts to shed light on the factors affecting the differing profitabilities among companies, particularly, the effect of refinery upgrading, to contribute toward a better understanding of the performance of the domestic petroleum refining industry. The determinants of domestic refining-marketing profitability in the short run are evaluated. The focus is on those factors affecting the profitability of operations using the existing capital stock. Of particular interest is the effect on profitability of investments made for refinery upgrading. The refining-marketing segment is assumed to be operated to maximize profits of that segment rather than the profits of some other segment. The cost and financial data used in the analysis are proprietary line-of-business data from the FRS. The FRS provides detailed information on refining-marketing revenue, cost, income, and investment. The specific data used are discussed and key definitions provided later in this report. 14 refs., 1 fig., 2 tabs.

  7. Profitable solutions to climate, oil, and proliferation.

    Science.gov (United States)

    Lovins, Amory B

    2010-05-01

    Protecting the climate is not costly but profitable (even if avoided climate change is worth zero), mainly because saving fuel costs less than buying fuel. The two biggest opportunities, both sufficiently fast, are oil and electricity. The US, for example, can eliminate its oil use by the 2040s at an average cost of $15 per barrel ($2000), half by redoubled efficiency and half by alternative supplies, and can save three-fourths of its electricity more cheaply than operating a thermal power station. Integrative design permits this by making big energy savings cheaper than small ones, turning traditionally assumed diminishing returns into empirically observed expanding returns. Such efficiency choices accelerate climate-safe, inexhaustible, and resilient energy supply-notably the "micropower" now delivering about a sixth of the world's electricity and 90% of its new electricity. These cheap, fast, market-financeable, globally applicable options offer the most effective, yet most underestimated and overlooked, solutions for climate, proliferation, and poverty.

  8. Maximum Profit Configurations of Commercial Engines

    Directory of Open Access Journals (Sweden)

    Yiran Chen

    2011-06-01

    Full Text Available An investigation of commercial engines with finite capacity low- and high-price economic subsystems and a generalized commodity transfer law [n ∝ Δ (P m] in commodity flow processes, in which effects of the price elasticities of supply and demand are introduced, is presented in this paper. Optimal cycle configurations of commercial engines for maximum profit are obtained by applying optimal control theory. In some special cases, the eventual state—market equilibrium—is solely determined by the initial conditions and the inherent characteristics of two subsystems; while the different ways of transfer affect the model in respects of the specific forms of the paths of prices and the instantaneous commodity flow, i.e., the optimal configuration.

  9. Full truckload vehicle routing problem with profits

    Directory of Open Access Journals (Sweden)

    Jian Li

    2014-04-01

    Full Text Available A new variant of the full truckload vehicle routing problem is studied. In this problem there are more than one delivery points corresponding to the same pickup point, and one order is allowed to be served several times by the same vehicle or different vehicles. For the orders which cannot be assigned because of resource constraint, the logistics company outsources them to other logistics companies at a certain cost. To maximize its profits, logistics company decides which to be transported by private fleet and which to be outsourced. The mathematical model is constructed for the problem. Since the problem is NP-hard and it is difficult to solve the large-scale problems with an exact algorithm, a hybrid genetic algorithm is proposed. Computational results show the effectiveness of the hybrid genetic algorithm.

  10. Pharmaceutical technology management--profitable business avenue.

    Science.gov (United States)

    Puthli, Shivanand P

    2010-01-01

    Growing research expenditure, regulatory framework and generic erosion have forced pharmaceutical companies globally to resort to pharmaceutical technology management (PTM). Indeed, the pharmaceutical industry has witnessed the impact of innovative drug delivery and device technologies and their influence on business. PTM has given a new business insight with greater profits and enhancement of product franchise. Promising breakthrough technologies have not been able to reach a commercial platform largely owing to lack of capital at the preliminary stages of the product development program. Intellectual property plays a considerable role in protecting innovative technologies. Joint ventures and strategic alliances also become important for commercializing a new technology. The synergy of PTM with options of in-licensing is expected to infuse newer opportunities to the pharmaceutical business.

  11. There's no profiting from a joint venture misadventure.

    Science.gov (United States)

    Herschman, Gary W

    2004-10-01

    In St. David's vs. IRS, a not-for-profit health system effectively challenged the IRS's determination that the system should be disqualified from tax exemption because it had entered a 50/50 joint venture with a for-profit system. The court decisions in St. David's, coupled with a recent IRS ruling, Revenue Ruling 2004-51, provide insight into how a not-for-profit hospital can structure such a joint venture to avoid jeopardizing its tax-exempt status.

  12. Analisis Teknikal Untuk Mendapatkan Profit Dalam Forex Trading Online

    OpenAIRE

    Liyanto, .; Alwiyah, .

    2012-01-01

    Technical Analysis To Obtain Profit From Online Forex Trading. The purpose of the research is to find profitable consistency in predicting price movement, especially on pairs GBPUSD and EURUSD using candlestick, moving average convergence divergence (MACD) and stochastic oscillator as parts of technical analysis before taking an action whether to buy or to sell forex. The profit is calculated for every given buy-sell signal after considering transaction cost in the amount of spread. The desig...

  13. Investigating the effect of different factors on profitability

    Directory of Open Access Journals (Sweden)

    Mohsen Hamidian

    2014-11-01

    Full Text Available This paper presents an empirical investigation to study the effects of different factors influencing on profitability of shares of petrochemical industry. The study gathers the information of three firms whose stock prices were listed on Tehran Stock Exchange over the period 2006-2012. Using different regression analysis, the study has determined that while stock price, currency rate and material influence on profitability of these firms, energy price, liquidity and gold price had no impact on profitability in petrochemical industry.

  14. Benefits and Costs of For-Profit Public Education

    Directory of Open Access Journals (Sweden)

    Alex Molnar

    2001-04-01

    Full Text Available As a policy initiative, for-profit operation of public schools has not lived up to the claims of its proponents. An examination of issues such as teaching methods, academic achievement, autonomy, local control, and the image and influence of for-profit public schools suggests that "for-profits" are unlikely to succeed in the long term in improving the overall quality of public education. They do, however, seem capable of harming public schools.

  15. Components of the Profitability of Technical Currency Trading

    OpenAIRE

    Schulmeister, Stephan

    2005-01-01

    This paper investigates the sources of the profitability of 1024 moving average and momentum models when trading in the German mark (euro)/U.S. dollar market based on daily data. The main results are as follows. First, each of these models would have been profitable over the entire sample period. Second, this profitability is exclusively due to the exploitation of persistent exchange rate trends. Third, these results do not change substantially when trading is examined within subperiods. Four...

  16. Risk Sharing and Layoff Risk in Profit Sharing

    OpenAIRE

    Fabella, Raul V.

    1995-01-01

    We show that if the employer is risk averse, however slightly, there is always a profit sharing contract that will Pareto-dominate the spot wage contract in the sense of pure risk sharing. The smaller is the employer risk aversion, the narrower is the room for profit sharing. The higher the workers value employment stability (less layoff risk), the more Pareto attractive is profit sharing regardless of employer risk aversion.

  17. Rates of profit as correlated sums of random variables

    Science.gov (United States)

    Greenblatt, R. E.

    2013-10-01

    Profit realization is the dominant feature of market-based economic systems, determining their dynamics to a large extent. Rather than attaining an equilibrium, profit rates vary widely across firms, and the variation persists over time. Differing definitions of profit result in differing empirical distributions. To study the statistical properties of profit rates, I used data from a publicly available database for the US Economy for 2009-2010 (Risk Management Association). For each of three profit rate measures, the sample space consists of 771 points. Each point represents aggregate data from a small number of US manufacturing firms of similar size and type (NAICS code of principal product). When comparing the empirical distributions of profit rates, significant ‘heavy tails’ were observed, corresponding principally to a number of firms with larger profit rates than would be expected from simple models. An apparently novel correlated sum of random variables statistical model was used to model the data. In the case of operating and net profit rates, a number of firms show negative profits (losses), ruling out simple gamma or lognormal distributions as complete models for these data.

  18. Alternative quality measures and profitability of hospital inpatient services offered.

    Science.gov (United States)

    Self, Donald R; Hegji, Charles E; Self, Robin M

    2010-01-01

    In this analysis, we study the relationship between hospital quality and hospital profits for a sample of 88 Alabama (USA) hospitals. Quality is measured by three groups of procedures performed on newly admitted patients as suggested by the Center for Medicare and Medicaid Services and the Health Quality Alliance (HQA) as well as a weighted quality measure. Profit is measured for eight hospital services. Profits from cardiac care were most responsive to the quality measures studied. Moreover, profits from six of the inpatient services increased as the weighted quality measure increased. Finally, in two cases quality increased with the relative number of employees a hospital utilized.

  19. Propolis inhibits osteoclast maturation.

    Science.gov (United States)

    Pileggi, Roberta; Antony, Kathryn; Johnson, Kristie; Zuo, Jian; Shannon Holliday, L

    2009-12-01

    Propolis, a natural product produced by the honey bee, has been successfully used in medicine as an anti-inflammatory and antimicrobial agent. Traumatic injuries to the teeth, especially avulsion injuries, present a challenging situation for the clinician because of post-treatment complications, such as inflammatory and/or replacement resorption. Agents that reduce osteoclast numbers and activity may be useful in the treatment of traumatic injuries to the teeth. In this study, we evaluated propolis as an anti-resorptive agent. Calcitriol-stimulated mouse marrow cultures, which contain both osteoclasts and osteoblasts, were exposed to the ethanol extracts of propolis or vehicle control and stained for tartrate-resistant acid phosphatase (TRAP)-activity to identify osteoclasts. A significant, dose-dependent reduction in multinuclear TRAP+ cells was demonstrated, although the propolis treatment accommodated cell growth and survival (P Propolis also reduced the formation of actin rings in pure cultures of RAW 264.7 osteoclast-like cells, suggesting that it exerts direct actions on osteoclast maturation. In summary, our data suggest that propolis inhibits late stages of osteoclast maturation including fusion of osteoclasts precursors to form giant cells and formation of actin rings. This supports the hypothesis that it may prove useful as a medicament to reduce resorption associated with traumatic injuries to the teeth.

  20. Dendritic cell maturation and cross-presentation: timing matters!

    Science.gov (United States)

    Alloatti, Andrés; Kotsias, Fiorella; Magalhaes, Joao Gamelas; Amigorena, Sebastian

    2016-07-01

    As a population, dendritic cells (DCs) appear to be the best cross-presenters of internalized antigens on major histocompatibility complex class I molecules in the mouse. To do this, DCs have developed a number of unique and dedicated means to control their endocytic and phagocytic pathways: among them, the capacity to limit acidification of their phagosomes, to prevent proteolytic degradation, to delay fusion of phagosomes to lysosomes, to recruit ER proteins to phagosomes, and to export phagocytosed antigens to the cytosol. The regulation of phagocytic functions, and thereby of antigen processing and presentation by innate signaling, represents a critical level of integration of adaptive and innate immune responses. Understanding how innate signals control antigen cross-presentation is critical to define effective vaccination strategies for CD8(+) T-cell responses. © 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  1. The relationship of CSR and the business profit: can the most responsible companies be more profitable?

    Directory of Open Access Journals (Sweden)

    Antonio Miguel Gil Salmerón

    2016-10-01

    Full Text Available Persistent financial crisis and the cases of corruption afflicting Spain have broken the trust of society that forcefully demands an ethical, responsible and sustainable management of organizations, which are not immune to environmental problems. The effects of globalization, the introduction of tecnoestructura as a management model, technological and socio-economic changes have reshaped the cultural, management and ownership system of the current company, the company nowadays is transferred the responsibility to combine growth and competitiveness with social development and environmental improvement. This reconfiguration of business management model is implemented with the introduction of Corporate Social Responsibility (CSR in the strategic plans of the companies with the purpose of achieving a competitive advantage. The question is: can the most responsible companies be more profitable? The introduction of CSR in the organizational culture of the companies involved as a vector, accelerates the profitability of the companies that apply it: the higher level of CSR used, the more profitable the companies are. These conclusions are determined from a linear regression analysis comparing the ROA –return on assets– to CSR levels in a hundred companies with higher levels of sustainability that operate in Spain, according to a survey published in 2014 by the Monitor business Corporate Reputation (Merco

  2. Evaluating Banking Profit Performance in Ghana during and post Profit Decline: A five Step Du-Pont Approach

    Directory of Open Access Journals (Sweden)

    Baah Aye Kusi

    2015-11-01

    Full Text Available In this study we aimed at three objectives. First, identify and rank banks based on a composite score comprising of all five du-pont variables. Second, we identify variables in the five step du-pont set up that are most likely to influence bank ROE during and post profit declining periods. And third, we estimate a model to capture the variables that drive bank ROE during and post profit declining periods. We first establish from our rankings that, foreign banks in Ghana performed better during profit declining periods while the local banks performed better in post profit decline periods using the top ten banks as a benchmark in both periods. Employing Pearson correlation coefficients matrix, we recognized that operating profit margin, asset turnover and leverage were most likely to influence bank ROE in both time periods. We further employ OLS regression and find that bank ROE was impacted by operating profit margin and leverage during profit declining periods and post profit decline while tax effect added up in post profit declining periods.

  3. Mycobacterium tuberculosis Chaperonin 10 Is Secreted in the Macrophage Phagosome: Is Secretion Due to Dissociation and Adoption of a Partially Helical Structure at the Membrane?

    Science.gov (United States)

    Fossati, Gianluca; Izzo, Gaetano; Rizzi, Emanuele; Gancia, Emanuela; Modena, Daniela; Moras, Maria Luisa; Niccolai, Neri; Giannozzi, Elena; Spiga, Ottavia; Bono, Letizia; Marone, Piero; Leone, Eugenio; Mangili, Francesca; Harding, Stephen; Errington, Neil; Walters, Christopher; Henderson, Brian; Roberts, Michael M.; Coates, Anthony R. M.; Casetta, Bruno; Mascagni, Paolo

    2003-01-01

    To confirm that Mycobacterium tuberculosis chaperonin 10 (Cpn10) is secreted outside the live bacillus, infected macrophages were examined by electron microscopy. This revealed that the mycobacterial protein accumulates both in the wall of the bacterium and in the matrix of the phagosomes in which ingested mycobacteria survive within infected macrophages. To understand the structural implications underlying this secretion, a structural study of M. tuberculosis Cpn10 was performed under conditions that are generally believed to mimic the membrane environment. It was found that in buffer-organic solvent mixtures, the mycobacterial protein forms two main species, namely, a partially helical monomer that prevails in dilute solutions at room temperature and a dimer that folds into a β-sheet-dominated structure and prevails in either concentrated protein solutions at room temperature or in dilute solutions at low temperature. A partially helical monomer was also found and was completely associated with negatively charged detergents in a micelle-bound state. Remarkably, zwitterionic lipids had no effect on the protein structure. By using N- and C-truncated forms of the protein, the C- and N-terminal sequences were identified as possessing an amphiphilic helical character and as selectively associating with acidic detergent micelles. When the study was extended to other chaperonins, it was found that human Cpn10 is also monomeric and partially helical in dilute organic solvent-buffer mixtures. In contrast, Escherichia coli Cpn10 is mostly dimeric and predominately β-sheet in both dilute and concentrated solutions. Interestingly, human Cpn10 also crosses biological membranes, whereas the E. coli homologue is strictly cytosolic. These results suggest that dissociation to partially helical monomers and interaction with acidic lipids may be two important steps in the mechanism of secretion of M. tuberculosis Cpn10 to the external environment. PMID:12837802

  4. Operating Profitability of For-Profit and Not-for-Profit Florida Community Hospitals During Medicare Policy Changes, 2000 to 2010

    National Research Council Canada - National Science Library

    Langland-Orban, Barbara; Large, John T; Sear, Alan M; Zhang, Hanze; Zhang, Nanhua

    2015-01-01

    ...) and not-for-profit (NFP) hospital operating margins in Florida. FP hospitals were expected to be more adversely affected as admissions growth has been one strategy to improve stock performance, which is not a consideration at NFPs...

  5. Effect of Financing on Profitability of Sawmill Industries in Cross ...

    African Journals Online (AJOL)

    This study examined the Effect of Financing on Profitability of Sawmill Industries in Cross River State, Nigeria. The study was conducted at enterprise level in Cross River State with a sample of 80 saw millers to ascertain the effect of finance on their profitability. The result shows that amount borrowed business experience, ...

  6. A More Detailed Understanding Of Factors Associated With Hospital Profitability.

    Science.gov (United States)

    Bai, Ge; Anderson, Gerard F

    2016-05-01

    To identify the characteristics of the most profitable US hospitals, we examined the profitability of acute care hospitals in fiscal year 2013, measured as net income from patient care services per adjusted discharge. Based on Medicare Cost Reports and Final Rule Data, the median hospital lost $82 for each such discharge. Forty-five percent of hospitals were profitable, with 2.5 percent earning more than $2,475 per adjusted discharge. The ten most profitable hospitals, seven of which were nonprofit, each earned more than $163 million in total profits from patient care services. Hospitals with for-profit status, higher markups, system affiliation, or regional power, as well as those located in states with price regulation, tended to be more profitable than other hospitals. Hospitals that treated a higher proportion of Medicare patients, had higher expenditures per adjusted discharge, were located in counties with a high proportion of uninsured patients, or were located in states with a dominant insurer or greater health maintenance organization (HMO) penetration had lower profitability than hospitals that did not have these characteristics. These findings can inform policy reforms, while providing a baseline against which to measure the impact of any subsequent reforms. Project HOPE—The People-to-People Health Foundation, Inc.

  7. Methods utilized in evaluating the profitability of commercial space processing

    Science.gov (United States)

    Bloom, H. L.; Schmitt, P. T.

    1976-01-01

    Profitability analysis is applied to commercial space processing on the basis of business concept definition and assessment and the relationship between ground and space functions. Throughput analysis is demonstrated by analysis of the space manufacturing of surface acoustic wave devices. The paper describes a financial analysis model for space processing and provides key profitability measures for space processed isoenzymes.

  8. The relationship between size, growth and profitability of commercial banks

    NARCIS (Netherlands)

    Shehzad, C. T.; De Haan, J.; Scholtens, B.

    2013-01-01

    Using a dynamic panel model for more than 15 000 banks from 148 countries from 1988 to 2010, we investigate the interaction between size, growth and profitability of banks. For our total sample, we cannot reject the hypotheses that the variability of bank profitability and the level and variability

  9. Analysis of profitability and poverty reduction of yoghurt processing ...

    African Journals Online (AJOL)

    The study assessed the profitability of yoghurt processing with a view of determining its potentials for reducing poverty in Maiduguri Metropolitan Area. Data were collected from a survey of 10 yoghurt processing firms in Maiduguri and analysed using profit model and descriptive statistics. Results revealed that yoghurt ...

  10. A method for predicting the probability of business network profitability

    NARCIS (Netherlands)

    Johnson, P.; Iacob, Maria Eugenia; Välja, M.; van Sinderen, Marten J.; Magnusson, C; Ladhe, T.

    2014-01-01

    In the design phase of business collaboration, it is desirable to be able to predict the profitability of the business-to-be. Therefore, techniques to assess qualities such as costs, revenues, risks, and profitability have been previously proposed. However, they do not allow the modeler to properly

  11. Comparative Analysis of Profitability of Layers Production in Esan ...

    African Journals Online (AJOL)

    MICHAEL HORSFALL

    agricultural sector are rational, thus, they would increase their supply if they are sure of making higher profit ceteris paribus (Emokaro et al., 2009). Higher profit ..... Energy and Crude Protein Requirements for. Chicks of Nigeria Local Fowl and Crossbreeds. Int. J. Poult. Sci., 5:.271-274. Koutsoyiannis, A (2001). Theory of ...

  12. Profitability of Snail Production in Osun State,Nigeria | Baba ...

    African Journals Online (AJOL)

    The costs and returns analysis revealed that variable costs accounted for 96% of the production costs. Labour was the most costly single item in snail production in the area. The results further showed that snail farming was highly profitable, with the average farmer earning a net return of 40 naira per snail. There was a profit ...

  13. Summer 2012 Colorado Wildfire Non-Profit Sector Case Study

    Science.gov (United States)

    2012-11-01

    include commercial losses. Rocky Mountain Insurance Information Association is a non-profit consumer information organization . Affiliated with the...million. These estimates do not include commercial losses. Rocky Mountain Insurance Information Association is a non-profit consumer information ... organization . Affiliated with the Insurance Information Institute, RMIIA has been serving consumers and the media since 1952. 22 5.0 Observations

  14. Determinant of Profit Efficiency among Small Scale Traditional Palm ...

    African Journals Online (AJOL)

    This study was designed to examine the determinants of profit efficiency among traditional palm oil processing in Nigeria, using stochastic Cobb – Douglas profit frontier model. A Multi – Stage random sampling technique was used to select 240 traditional palm oil processors from which input – output data were collected.

  15. The implementation of customer profitability analysis: a case study

    NARCIS (Netherlands)

    van Raaij, E.M.; Vernooij, M.J.A.; Vernooij, Maarten J.A.; van Triest, S.P.

    2003-01-01

    By using customer profitability analysis (CPA), firms can determine the profit contribution of customer segments and/or individual customers. This article presents an approach for the implementation of CPA. The implementation process is illustrated using a case study of a firm producing and selling

  16. How's Business? Status Report #6 on For Profit Child Care.

    Science.gov (United States)

    Neugebauer, Roger

    1990-01-01

    Describes the growth of for-profit child care and indications of a potential slowdown. Discusses the declining expansion of major chains and the accelerated growth of midsize and small chains. Lists the nations' largest for-profit child care and center management organizations. (RJC)

  17. Profitability Analysis of Rice Processing and Marketing in Kano State ...

    African Journals Online (AJOL)

    ABSTRACT: The study determined the profitability of rice processing and marketing in Kano. State. The objective of the study was to assess the profitability levels of rice processing and marketing, evaluate the value added to the commodity at each stage in the study area and determine the most efficient services produce.

  18. Refined analysis results for multimedia network costs and profits

    DEFF Research Database (Denmark)

    Tahkokorpi, M.; Falch, Morten; Skouby, Knud Erik

    This deliverable describes the techno-economic business model developed in EURORIM WP3 and presents the refined results of the multimedia service delivery cost-profit calculations......This deliverable describes the techno-economic business model developed in EURORIM WP3 and presents the refined results of the multimedia service delivery cost-profit calculations...

  19. 45 CFR 74.81 - Prohibition against profit.

    Science.gov (United States)

    2010-10-01

    ... ORGANIZATIONS, AND COMMERCIAL ORGANIZATIONS Special Provisions for Awards to Commercial Organizations § 74.81 Prohibition against profit. Except for awards under the Small Business Innovation Research (SBIR) and Small... to any recipient even if the recipient is a commercial organization. Profit is any amount in excess...

  20. Academic Libraries in For-Profit Schools of Higher Education

    Science.gov (United States)

    Davis, Jinnie Y.; Adams, Mignon; Hardesty, Larry

    2011-01-01

    For-profit schools constitute the fastest-growing sector of higher education institutions in the United States. Yet accompanying the phenomenal growth of these proprietary colleges and universities has been considerable controversy over the role that the profit motive should play in higher education. The literature of higher education contains…

  1. The Nigerian Statements of Accounting Standards and Ribh (Profit ...

    African Journals Online (AJOL)

    However, the subject, profit (ribh), in relation to both conventional and Islamic accounting standards, has almost totally been neglected. This paper, therefore, investigates the determination of profit in line with the Nigerian Statements of Accounting Standards (SAS), conventional economics and Islamic economic ...

  2. 48 CFR 2115.404-71 - Profit analysis factors.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 6 2010-10-01 2010-10-01 true Profit analysis factors... TYPES CONTRACTING BY NEGOTIATION Contract Pricing 2115.404-71 Profit analysis factors. (a) The OPM... (service charge) for the FEGLI Program contract. In accordance with the factors defined in FAR 15.404-4(d...

  3. Management Control Systems in Not for Profit Organization

    OpenAIRE

    De La Cruz Marquez, Michelle

    2008-01-01

    The diploma thesis is about management control system. The first part contains the analysis of the subject, the factors, components and tools of management control. In the second part is about the difference of management control in profit and non-profit organizations.

  4. 26 CFR 509.105 - Industrial and commercial profits.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 19 2010-04-01 2010-04-01 false Industrial and commercial profits. 509.105...) REGULATIONS UNDER TAX CONVENTIONS SWITZERLAND General Income Tax § 509.105 Industrial and commercial profits... contracting States shall not be taxable by the other contracting State upon its industrial and commercial...

  5. Risk attitudes and profits among small enterprises in Nigeria

    NARCIS (Netherlands)

    Lammers, J.; Willebrands, D.; Hartog, J.

    2010-01-01

    This paper analyses the effect of risk attitudes of firm owners on profits among micro and small enterprises (MSEs) in Lagos, Nigeria. Higher risk perceptions are shown to have a significant positive effect on profits, whereas risk propensity has a negative or no effect. Education, age, being male,

  6. Profitability of cover crops for single and twin row cotton

    Science.gov (United States)

    With the increased interest in cover crops, the impact of adoption on profitability of cash crops is a common question from producers. The objective of this study was to evaluate the profitability of cover crops for single and twin row cotton (Gossypium hirsutum L.) in Alabama. This experiment inclu...

  7. Application of relationship marketing in non-profit organisations ...

    African Journals Online (AJOL)

    The concept of relationship marketing was born from this need for long-term interaction with customers. A variety of factors have over time contributed to a need for marketing in non-profit organisations, such as non-profit sports clubs and recreation centres at local and school levels, to offset the decrease in income and ...

  8. Short Term Effect of Consolidation on Profitability of Nigerian Banks ...

    African Journals Online (AJOL)

    The findings here confirm the existing controversy on whether or not mergers or acquisitions lead to improved profitability. What is however clear is that barring any effect of the present global economic meltdown; it may take some time for the EPS of most of the banks to change significantly. Key Words: EPS Profitability ...

  9. Profitability analysis of plantain marketing in Kaduna metropolis ...

    African Journals Online (AJOL)

    Descriptive statistics, Cost and return analysis, Herfindahl index, Gross ratio, Operating ratio, Expense structure ratio, Return per capital invested, Benefit cost ratio were used to analyze the data. The study showed that ... Analysis of the profit revealed that plantain marketing is a profitable business. The constraint militating ...

  10. Management and socio-economic determinants of profitability in dog ...

    African Journals Online (AJOL)

    Management and socio-economic determinants of profitability in dog breeding business in Oyo state, Nigeria. ... Descriptive statistics, univariate and multivariable analyses were done to determine predictors of profitability in dog breeding business. The mean age of respondents was 32.1 ± 7.7 years. The median year of ...

  11. Acquisition of the Profit Concept by Third-Grade Children.

    Science.gov (United States)

    Berti, Anna Emilia

    1992-01-01

    Conceptions of 50 third graders (aged 8-9 years) in Italy about shopkeepers' profit were examined using the Piagetian clinical procedure, with an interview followed by a comparison task that checked comprehension. Teaching children about profit had a higher impact at posttest on children who could compare correctly. (SLD)

  12. Distribution of Costs and Profits in Danish Urban Development

    DEFF Research Database (Denmark)

    Sørensen, Michael Tophøj; Christensen, Finn Kjær

    2009-01-01

    Most countries have a system – procedures and tools – for foreseeable, clear and fair distribution of costs and profits in urban development. However, the distribution of profits and costs between the municipality and the developers /landowners is in Denmark rather fragmented and not very transpa...

  13. Macroeconomy and Banks' Profitability in Nigeria | Chidozie | African ...

    African Journals Online (AJOL)

    It also seeks to examine the significance of microeconomic variables (cost to income ratio, loan to deposit ratio; loan to total assets ratio and total assets) on banks' profitability. It analysed the impact of banking industry concentration on banks' profitability. The estimation technique follows a panel regression which studied a ...

  14. THE PROFIT TARGET IN A RESTAURATION UNIT

    Directory of Open Access Journals (Sweden)

    Briciu Sorin

    2011-12-01

    Full Text Available The hospitality industry represents one of the most dynamic sectors of the contemporary society, with an emphasised role in the process of globalization. Currently, the hospitality industry does not only face the challenges of the economic crisis but the changes in the market, the consumers behaviour and the technological trends, too. That is why, in this time, it is extremely important to apply the management accounting and the cost calculation in any entity in the hospitality industry in order to cope with the market challenges. The main services are performed through the hospitality industry: the accommodation and the restauration. These services satisfy the vital needs of the tourists, but this industry must meet other needs or requests such as the acknowledgement of the social status, the desire to know other cultures or traditions, to spend free time in a pleasant manner etc. Our intention and goal in the current article is to approach an image of the CVP analysis in the decision making process with an emphasis on the restauration in the hospitality industry. In order to cope with this critical time, the competition and to achieve the profits estimated, the managers in the hospitality industry can apply the CVP analysis, one of the simplest and most useful analytical instruments. The paper will tackle with the problem of the break even point in a restaurant, one of the main indicators of the CVP model and also the possibility of the decision making process orientation.

  15. Determinants of the Profitability in the Czech Banking Industry

    Directory of Open Access Journals (Sweden)

    Iveta Palečková

    2016-12-01

    Full Text Available The aim of this paper is to estimate the banking profitability determinants of the Czech commercial banks during the period 2004-2014. For estimation of banking profitability we used three common measures, namely the Return on Assets, Return on Equity and Net Interest Margin. We estimated twelve determinants of banking performance. The effect of the determinants of banking profitability is estimated using panel data analysis. The data set is consists of seventeen commercial banks in the Czech Republic. The results show that the profitability was positively influenced by the bank’s size, capitalization, credit risk, level of concentration, ownership structure and bank’s market share. Number of branches of the bank had the negative impact on ROA and ROE. on the other hand, the variables Gross Domestic Product, interest rate, liquidity risk, riskiness of bank’s portfolio and affiliation with financial conglomerate have not got the significant influence on profitability of the Czech commercial banks.

  16. Analysis of alternative approach to determining of customers' profitability level

    Directory of Open Access Journals (Sweden)

    Michal Vodák

    2007-01-01

    Full Text Available This paper describes alternative approach to analysis of customers profitability based just on volume of purchased goods. By including average distance of customers' distributional places as additional criteria for profitability analysis and using cluster analysis as a method for ranking customers is proven that assessing of customers' profitability can be more accurate.This approach to evaluation of customers' profitability changes order of customers listed acordingly to profit they generate. In fact it shows that in business terms is room for improvement and harmonisation of relationship among some business partners in certain cases. Recalculation of business conditions which comes from detailed analysis can bring either increase of competitiveness by price reduction or increase of incomes by rising price of goods.

  17. The Legionella Kinase LegK2 Targets the ARP2/3 Complex To Inhibit Actin Nucleation on Phagosomes and Allow Bacterial Evasion of the Late Endocytic Pathway

    Science.gov (United States)

    Michard, Céline; Sperandio, Daniel; Baïlo, Nathalie; Pizarro-Cerdá, Javier; LeClaire, Lawrence; Chadeau-Argaud, Elise; Pombo-Grégoire, Isabel; Hervet, Eva; Vianney, Anne; Gilbert, Christophe; Faure, Mathias; Cossart, Pascale

    2015-01-01

    ABSTRACT Legionella pneumophila, the etiological agent of legionellosis, replicates within phagocytic cells. Crucial to biogenesis of the replicative vacuole is the Dot/Icm type 4 secretion system, which translocates a large number of effectors into the host cell cytosol. Among them is LegK2, a protein kinase that plays a key role in Legionella infection. Here, we identified the actin nucleator ARP2/3 complex as a target of LegK2. LegK2 phosphorylates the ARPC1B and ARP3 subunits of the ARP2/3 complex. LegK2-dependent ARP2/3 phosphorylation triggers global actin cytoskeleton remodeling in cells, and it impairs actin tail formation by Listeria monocytogenes, a well-known ARP2/3-dependent process. During infection, LegK2 is addressed to the Legionella-containing vacuole surface and inhibits actin polymerization on the phagosome, as revealed by legK2 gene inactivation. Consequently, LegK2 prevents late endosome/lysosome association with the phagosome and finally contributes to remodeling of the bacterium-containing phagosome into a replicative niche. The inhibition of actin polymerization by LegK2 and its effect on endosome trafficking are ARP2/3 dependent since it can be phenocopied by a specific chemical inhibitor of the ARP2/3 complex. Thus, LegK2-ARP2/3 interplay highlights an original mechanism of bacterial virulence with an unexpected role in local actin remodeling that allows bacteria to control vesicle trafficking in order to escape host defenses. PMID:25944859

  18. 26 CFR 1.901-2T - Income, war profits, or excess profits tax paid or accrued (temporary).

    Science.gov (United States)

    2010-04-01

    ... subject to tax on the basis of place of management, place of incorporation or similar criterion or... loss recognized by FC for country Z tax purposes, and pursuant to a group relief regime in country Z FC... 26 Internal Revenue 9 2010-04-01 2010-04-01 false Income, war profits, or excess profits tax paid...

  19. For-profit Hospitals: A comparative and longitudinal study of the for-profit hospital sector in four Western countries

    NARCIS (Netherlands)

    P.P.T. Jeurissen (Patrick)

    2010-01-01

    textabstractMany now argue that for-profit hospital ownership is on the rise because of the retrenchment of public entitlements and – often more importantly in health care – pro-market reforms in the delivery of these services1. Most theoretical notions assume that for-profit hospitals are more

  20. Examining Not-for-Profit Higher Education Faculty Attitudes and Knowledge toward For-Profit Higher Education Institutions

    Science.gov (United States)

    Karpel, Nichole

    2013-01-01

    Over the last decade, for-profit higher education has been the fastest growing segment within higher education. Despite the growth, little research exists about for-profit higher education institutions. The purpose of this exploratory, descriptive, quantitative study was to examine the attitudes and knowledge of higher education faculty toward…

  1. Costs, commitment and locality: a comparison of for-profit and not-for-profit health plans.

    Science.gov (United States)

    2004-01-01

    Following on the heels of the first national study demonstrating differences in the community benefits provided by not-for-profit and for-profit health maintenance organizations (HMOs) (Schlesinger, Mitchell, and Gray 2003), this study of the New York state market shows significant differences in premiums, administrative overhead and commitment to safety net coverage between nonprofit and for-profit health plans. This study shows that for-profit health plans do act differently than not-for-profit plans in terms of performance, efficiency, and contribution to safety net programs. Moreover, it suggests that not-for-profit health insurers operating in a predominantly for-profit market act in many ways like for-profits. The New York state insurance market provides an ideal study environment because one can compare a large number of policyholders and plans in both business models (for-profit and not-for-profit) that share an identical legislative and regulatory environment. New York has large populations being provided coverage under both models and no allowances had to be made for state-to-state political and/or legal differences. Specifically, this study shows that: The downstate insurance market is predominantly for-profit, while the upstate market is almost entirely not-for-profit. The recent conversion of Empire Blue Cross Blue Shield to a for-profit model moves the downstate market further into the for-profit column, while the upstate region remains not-for-profit. Insurers in the upstate not-for-profit market are more administratively efficient than insurers in the downstate region. Compared to the downstate region, insurers in upstate New York spent 1.5% less of their operating revenues on administrative expenses. The additional 1.5% of spending on administrative expenses downstate totals dollars 137,000,000. Upstate insurers spend significantly more of the revenues received on payments for medical care. Downstate insurers spent 80.4% of operating revenues on

  2. Maturational and Non-Maturational Factors in Heritage Language Acquisition

    Science.gov (United States)

    Moon, Ji Hye

    2012-01-01

    This dissertation aims to understand the maturational and non-maturational aspects of early bilingualism and language attrition in heritage speakers who have acquired their L1 incompletely in childhood. The study highlights the influential role of age and input dynamics in early L1 development, where the timing of reduction in L1 input and the…

  3. Profit (p-index: the degree to which authors profit from co-authors.

    Directory of Open Access Journals (Sweden)

    Nasir Ahmad Aziz

    Full Text Available Current metrics for estimating a scientist's academic performance treat the author's publications as if these were solely attributable to the author. However, this approach ignores the substantive contributions of co-authors, leading to misjudgments about the individual's own scientific merits and consequently to misallocation of funding resources and academic positions. This problem is becoming the more urgent in the biomedical field where the number of collaborations is growing rapidly, making it increasingly harder to support the best scientists. Therefore, here we introduce a simple harmonic weighing algorithm for correcting citations and citation-based metrics such as the h-index for co-authorships. This weighing algorithm can account for both the nvumber of co-authors and the sequence of authors on a paper. We then derive a measure called the 'profit (p-index', which estimates the contribution of co-authors to the work of a given author. By using samples of researchers from a renowned Dutch University hospital, Spinoza Prize laureates (the most prestigious Dutch science award, and Nobel Prize laureates in Physiology or Medicine, we show that the contribution of co-authors to the work of a particular author is generally substantial (i.e., about 80% and that researchers' relative rankings change materially when adjusted for the contributions of co-authors. Interestingly, although the top University hospital researchers had the highest h-indices, this appeared to be due to their significantly higher p-indices. Importantly, the ranking completely reversed when using the profit adjusted h-indices, with the Nobel laureates having the highest, the Spinoza Prize laureates having an intermediate, and the top University hospital researchers having the lowest profit adjusted h-indices, respectively, suggesting that exceptional researchers are characterized by a relatively high degree of scientific independency/originality. The concepts and methods

  4. Uncompensated care provided by for-profit, not-for-profit, and government owned hospitals

    Directory of Open Access Journals (Sweden)

    Vaughan-Sarrazin Mary S

    2010-04-01

    Full Text Available Abstract Background There is growing concern certain not-for-profit hospitals are not providing enough uncompensated care to justify their tax exempt status. Our objective was to compare the amount of uncompensated care provided by not-for-profit (NFP, for-profit (FP and government owned hospitals. Methods We used 2005 state inpatient data (SID for 10 states to identify patients hospitalized for three common conditions: acute myocardial infarction (AMI, coronary artery bypass grafting (CABG, or childbirth. Uncompensated care was measured as the proportion of each hospital's total admissions for each condition that were classified as being uninsured. Hospitals were categorized as NFP, FP, or government owned based upon data obtained from the American Hospital Association. We used bivariate methods to compare the proportion of uninsured patients admitted to NFP, FP and government hospitals for each diagnosis. We then used generalized linear mixed models to compare the percentage of uninsured in each category of hospital after adjusting for the socioeconomic status of the markets each hospital served. Results Our cohort consisted of 188,117 patients (1,054 hospitals hospitalized for AMI, 82,261 patients (245 hospitals for CABG, and 1,091,220 patients for childbirth (793 hospitals. The percentage of admissions classified as uninsured was lower in NFP hospitals than in FP or government hospitals for AMI (4.6% NFP; 6.0% FP; 9.5% government; P Conclusions For the three conditions studied NFP and FP hospitals appear to provide a similar amount of uncompensated care while government hospitals provide significantly more. Concerns about the amount of uncompensated care provided by NFP hospitals appear warranted.

  5. [Profitability analysis of clinical risk management].

    Science.gov (United States)

    Banduhn, C; Schlüchtermann, J

    2013-05-01

    Medical treatment entails many risks. Increasingly, the negative impact of these risks on patients' health is revealed and corresponding cases are reported to hospital insurances. A systematic clinical risk management can reduce risks. This analysis is designed to demonstrate the financial profitability of implementing a clinical risk management. The decision analysis of a clinical risk management includes information from published articles and studies, publicly available data from the Federal Statistical Office and expert interviews and was conducted in 2 scenarios. The 2 scenarios result from a maximum and minimum value of preventable adverse events reported in Germany. The planning horizon was a 1-year ­period. The analysis was performed from a hospital's perspective. Subsequently, a threshold-analysis of the reduction of preventable adverse events as an effect of clinical risk management was executed. Furthermore, a static capital budgeting over a 5-year period was added, complemented by a risk analysis. Regarding the given assumptions, the implementation of clinical risk management would save about 53 000 € or 175 000 €, respectively, for an average hospital within the first year. Only if the reduction of preventable adverse events is as low as 5.6 or 2.8%, respectively, will the implementation of clinical risk management produce losses. According to a comprehensive risk simulation this happens in less than one out of 1 million cases. The investment in a clinical risk management, based on a 5-year period and an interest rate of 5%, has an annually pay off of 81 000 € or 211 000 €, respectively. The implementation of clinical risk management in a hospital pays off within the first year. In the subsequent years the surplus is even higher due to the elimination of implementation costs. © Georg Thieme Verlag KG Stuttgart · New York.

  6. Protein production: planet, profit, plus people?

    Science.gov (United States)

    Aiking, Harry

    2014-07-01

    Food sustainability and food security are increasingly in the spotlight and increasingly intertwined. According to some projections we will need to nearly double food production in the next 4 decades. This article argues that protein production and consumption are pivotal to sustainability, because anthropogenic contributions to the nitrogen cycle are 100-200% compared with a contribution of 1-2% to the carbon cycle by mineral fuel combustion, with biodiversity as the main casualty. Because 1 kg animal protein requires ∼ 6 kg plant protein, its large-scale production by means of factory farming is a major driver of biodiversity loss, climate change, and freshwater depletion. Furthermore, intensive livestock production is associated with antibiotics resistance and increasing incidence of emerging diseases. Therefore, a "reversed" diet transition back to less animal protein could make a difference. Some European countries, such as the United Kingdom, Sweden, and The Netherlands, have published integrated policy reports addressing food security, sustainability, and health combined. The food industry is focusing on food safety and increasingly on sustainability. An important issue is consumer communication, because consumer "framing" is radically different from that of governmental and industrial policy makers. There is no "one size fits all." A huge range of differences exists between countries and between distinct groups of consumers within countries; getting consumers to change their diets in a more sustainable direction is likely to require much more than gentle nudging. National governments and the United Nations should assume their responsibilities and initiate a global strategy integrating sustainability, food security, nutrition, and equity. To date, the profit pillar of sustainability has taken precedence over planet and people. It is time to redress the balance. © 2014 American Society for Nutrition.

  7. DETERMINANTS OF BANKS’ PROFITABILITY IN REPUBLIC OF MACEDONIA

    Directory of Open Access Journals (Sweden)

    TATJANA SPASESKA

    2017-04-01

    Full Text Available The commercial banks are important financial institutions in the financial system and the economy. As financial intermediaries, banks play a crucial role in the economic growth of the country through making available the funds for investors to borrow as well as financial deepening in the country. Therefore, the success of working in the banks creates possibilities for more efficient (cheaper crediting of economic entities which results in an increased potential for investing of the enterprises and encouraging the personal people’s spending. Namely, the banking system profitability is the most important instrument of the financing system that has positive influence on potential growth of each national economy. The objective of this study is to investigate the determinants in bank profitability in R. Macedonia. For that reason, Return of Assets, Return of Equity and Net Interest Margin, are taken as indicators of the banks’ profitability. On the other hand, the determinants influencing profitability are grouped into two categories, i.e. internal and external. The bank internal determinants, which were thought to have effects on profitability, are total loans, asset quality (non-performing loan to total loan ratio, capital adequacy and total deposit to total assets. In our study we use the gross domestic product and inflation rate as external determinants of bank profitability. The results indicate that the bank specific determinants have been more effect than macroeconomic factors on profitability of the banks

  8. Profitability of Serbian banking sector during global economic crisis

    Directory of Open Access Journals (Sweden)

    Marko M Miljković

    2013-12-01

    Full Text Available The aim of the paper is to identify the main factors which contributed to decline of profitability in Serbian banking sector during the period of global economic crisis. There are presented different theories of banking sector profitability and results of scientifically significant empirical researches from economic literature. Following ratios were used as measure of profitability: return on assets (ROA, return on equity (ROE, net interest gain to total revenue, net fees and commissions gain to total revenue, and net pre-tax profit/loss to total revenue ratio. The profitability was analyzed for the whole Serbian banking sector in the period 2008-2012 and particularly for the 15 largest banks according to total assets value in 2012. The empirical analysis indicated that one of the most important factors contributing to high amounts of losses of commercial banks in the previous period includes an increase of net operating expenses, especially expenses on account of a write-off of non-performing loans (NPL. Furthermore, there were analyzed the dynamics of interest rates and interest spread as a factor with certain impact on profitability of banks. Finally, it is estimated that the prospects for intensive growth of profitability in the banking sector of Serbia in the mid-term are poor.

  9. Whose Maturity is it Anyway?

    DEFF Research Database (Denmark)

    Lasrado, Lester Allan; Vatrapu, Ravi; Mukkamala, Raghava Rao

    2017-01-01

    This paper presents results from an ongoing empirical study that seeks to understand the influence of different quantitative methods on the design and assessment of maturity models. Although there have been many academic publications on maturity models, there exists a significant lack of understa...

  10. The Persistence of Profits in Azerbaijan's Banking System

    Directory of Open Access Journals (Sweden)

    K. Batu TUNAY

    2015-06-01

    Full Text Available In this research, the persistence of profits in Azerbaijan's banking sector in the short-run and the long-run is investigated. Although there are a lot of researches done in the case of different countries, enough study has been implemented for the case of Azerbaijan despite of its high speed economic growth. This research analysis continuity of profits by using system panel data method. Obtained results indicate that profits demonstrate no persistence or a little persistence. In this context, existence of competitive powers in the sector can be stated.

  11. Comparing profitability of Burlina and Holstein Friesian cattle breeds

    Directory of Open Access Journals (Sweden)

    Martino Cassandro

    2010-01-01

    Full Text Available Aim of this study was to compare profitability of Burlina and Holstein Friesian cows in northern Italy. Cow’s profitability was calculated for each breed, with consideration of economic incentive programs and alternative milk pricing scenarios. The difference in annual profitability between Burlina and Holstein Friesian ranged from −€719 to −€274 per cow per year. In a low-input management level with a cow’s incentive payment and a specific cheese market strategy the low milk yield of Burlina can be compensate respect to Holstein Friesian.

  12. Determinants of bank profitability: Evidence from the Greek banking sector

    Directory of Open Access Journals (Sweden)

    Alexiou Constantinos

    2009-01-01

    Full Text Available This paper investigates the effects of bank-specific and macroeconomic determinants of bank profitability, using an empirical framework that incorporates the traditional Structure-Conduct- Performance (SCP hypothesis. A panel data approach has been adopted and effectively applied to six Greek banks. The evidence generated suggests that for any consistent or systematic size the profitability relationship is relatively weak. Most of the bank-specific determinants were found to significantly affect bank profitability. A more ambiguous picture emerged when the macroeconomic factors were considered.

  13. A MANAGERIAL AND COST ACCOUNTING APPROACH OF CUSTOMER PROFITABILITY ANALYSIS

    Directory of Open Access Journals (Sweden)

    CARDOS Ildiko Reka

    2010-07-01

    Full Text Available In the last years many organizations realized that market orientation is essential to their success. Satisfying the needs of customers, offering them products and services which meet their desires and demands, customer loyalty can increase profitability for long term. After analyzing the existing journal literature in this field we would like to emphasize that managerial accounting, cost calculation methods and techniques, the analysis of costs provides relevant information when analyzing the customer’s profitability. We pay special attention on cost systems. An activity based costing approach takes customer profitability to new levels of accuracy and usefulness, provides the basis for creating, communicating and delivering value to the customers.

  14. Aging: compensation or maturation?

    Science.gov (United States)

    Aine, Cheryl J; Woodruff, Chad C; Knoefel, Janice E; Adair, John C; Hudson, David; Qualls, Clifford; Bockholt, Jeremy; Best, Elaine; Kovacevic, Sanja; Cobb, Wayne; Padilla, Denise; Hart, Blaine; Stephen, Julia M

    2006-10-01

    Neuroimaging studies of healthy aging often reveal differences in neural activation patterns between young and elderly groups for episodic memory tasks, even though there are no differences in behavioral performance. One explanation typically offered is that the elderly compensate for their memory deficiencies through the recruitment of additional prefrontal regions. The present study of healthy aging compared magnetoencephalographic (MEG) time-courses localized to specific cortical regions in two groups of subjects (20-29 years and >or=65 years) during a visual delayed-match-to-sample (DMS) task. MR morphometrics and neuropsychological test results were also examined with the hope of providing insight into the nature of the age-related differences. The behavioral results indicated no differences in performance between young and elderly groups. Although there was a main effect of age on the latency of the initial peak in primary/secondary visual cortex, these longer latencies were not correlated with the performance of elderly on the DMS task. The lateral occipital gyrus (LOG) revealed qualitatively different patterns of activity for the two age groups corroborated by neuropsychological test results. Morphometric results for the young versus elderly groups revealed less white (WM) and gray matter (GM) volumes in the frontal lobes of the elderly. When a group of middle-aged subjects (33-43 years) was included in the morphometric analyses, the middle-aged subjects revealed statistically greater WM volumes in frontal and parietal cortex suggesting immature WM tracts in the young. Perhaps our elderly utilized a different strategy compared to the young due to the different brain maturation levels of these groups.

  15. Profit Function Approximations and Duality Applications to Agriculture

    National Research Council Canada - National Science Library

    Gary D. Thompson; Mark Langworthy

    1989-01-01

    Monte Carlo simulations of profit functions indicate that flexible functional forms may be ranked nearly the same with respect to Allen-Uzawa partial substitution elasticities or price and fixed factor elasticities...

  16. A study on relationship between working capital and profitability

    Directory of Open Access Journals (Sweden)

    Hassan Ghodrati

    2014-08-01

    Full Text Available This paper studies the relationship between working capital management and profitability of accepted corporations in Tehran Stock Exchange over the period 2008-2012. The study selected 66 firms as a statistical sample based on Cochran formula and simple random selection. In this study, variables including the average period of collecting accordance, periods of circulation of inventories, the average period of debt payment, and cycle of cash conversion on the factories operating profits are studied. The research method is applied and collection of data is solidarity, the Pierson and Regression solidarity are used. Results show that variables of capital investment management and profitability were in opposite direction. If the period of collecting accordance, period of debt payment, period of circulation of inventories and the cycle of cash conversion increase, it decreases the period profitability and the manager can decrease the period of debt payment, period of cash conversion to the least amount of positive value for affiliate.

  17. The Significance of Loyalty on Consumer Credit Profitability

    Directory of Open Access Journals (Sweden)

    Aditya Galih Prihartono

    2012-04-01

    Full Text Available The purpose of this research is to analyze and test the effect of customer loyalty on consumer credit profitability. Loyalty Index Score was developed to determine the level of customers’ loyalty level through 4 main variables; Longevity, Depth, Breadth and Referrals. The effect of Loyalty Index Score on profitability was further tested by path analysis to find out the significance direct relationship between loyalty and profitablity and the indirect relationship between the two variable through bucket. The result showed that loyalty has a significant effect on profitability either directly or indirectly. It was concluded that direct loyalty effect on profitability is lower than that of the indirect effect through bucket. The conclusion could be made by analyzing the available data from personal loan customers in one of the biggest multinational bank in indonesia during October 2010 until March 2011.

  18. Profitability of fungicide use decisions among cocoa farmers in south ...

    African Journals Online (AJOL)

    CRIN) recommended fungicide use rate with profit maximization objective of Nigerian cocoa farmers. To achieve this research objective, a cross-sectional survey of cocoa farmers in four local government areas (LGAs) each in Osun and Ondo ...

  19. Distribution of Costs and Profits in Urban Development

    DEFF Research Database (Denmark)

    Christensen, Finn Kjær; Sørensen, Michael Tophøj

    2009-01-01

    Most countries have a system - procedures and tools - for foreseeable, clear and fair distribution of costs and profits in urban development. However, the distribution of profits and costs between the municipality and the developers /landowners is in Denmark rather fragmented and not very...... transparent as the distribution is regulated throughout the whole planning and environmental regulation system. Furthermore, development agreements – an “old” tool in many countries and an efficient tool to distribute profits and costs between the public and private sector – have only recently become possible...... in Denmark, and only under some special circumstances. This paper aims to clarify how costs and profits are distributed between the municipality and the developers /landowners in Denmark. The paper analyses how the Danish planning and environmental regulation system handles this issue. Based on the analysis...

  20. EXAMINATION OF IMPACT OF PHARMA R&D ON PROFITABILITY

    National Research Council Canada - National Science Library

    Gergo Tomori;

    2014-01-01

    .... This latter requires the examination of the impact of research and development activity as the most important factor to the profitability of two selected regional market leader pharma companies...

  1. Grants Management Guidance for Non-Profit Organizations

    Science.gov (United States)

    This guidance is intended to provide non-profit grant recipients with information to ensure that their organizations remain in compliance with the Code of Federal Regulations (CFR), Office of Management (OMB) cost principles, and the terms and conditions.

  2. Determinants of Profitability of Insurance Firms in Ghana

    Directory of Open Access Journals (Sweden)

    Eric Kofi Boadi

    2013-07-01

    Full Text Available The general objective of the study is to find out the determinants of the profitability of insurance firms in Ghana. Secondary data on financial reports were collected from sixteen insurance firms in Ghana for the period 2005 to 2010.The study was quantitative in nature. It adopted the longitudinal time dimension, specifically, the panel method and ordinary least square regression. The study discovered that, apart from tangibility which has a negative relationship, there is a positive relationship between leverage, liquidity and profitability of insurance firms in Ghana. It was also concluded that, the profitability model adopted has been explained in respect to all the independent variables and that the degree of error is less than 20%. Finally, it is suggested that the explanatory variables used in this study should be regressed on Return on Equity to find their extent of relationship on profitability.

  3. Determinants of bank profitability: Evidence from the Greek banking sector

    National Research Council Canada - National Science Library

    Alexiou, Constantinos; Sofoklis, Voyazas

    2009-01-01

    This paper investigates the effects of bank-specific and macroeconomic determinants of bank profitability, using an empirical framework that incorporates the traditional Structure-Conduct- Performance (SCP) hypothesis...

  4. For-Profit Institutions and Student Veteran Data

    Science.gov (United States)

    Jones, Kevin C.; Fox Garrity, Bonnie K.

    2017-01-01

    This chapter explores the lack of data about student veterans and reasons this lack of data raises particular concerns about for-profit institutions, which enroll a large percentage of student veterans.

  5. Research Ethics and Commercial Drug Development: When Integrity Threatens Profitability

    OpenAIRE

    Bélisle Pipon, Jean-Christophe

    2016-01-01

    This case, based on personal experiences and on those found in the literature, highlights the delicate tension faced by drug development companies having to balance research integrity and their profitability.

  6. Research Ethics and Commercial Drug Development: When Integrity Threatens Profitability

    Directory of Open Access Journals (Sweden)

    Bélisle Pipon, Jean-Christophe

    2016-05-01

    Full Text Available This case, based on personal experiences and on those found in the literature, highlights the delicate tension faced by drug development companies having to balance research integrity and their profitability.

  7. RESEARCH ON MILK COST, RETURN AND PROFITABILITY IN DAIRY FARMING

    National Research Council Canada - National Science Library

    Agatha POPESCU

    2014-01-01

    The paper aimed to the relationship between milk cost in terms of material cost and labor cost and estimate theinfluence of these costs on returns coming from milk and profitability in 5 small dairy...

  8. The Determinants of Bank Profitability: The Case of Tunisia

    Directory of Open Access Journals (Sweden)

    Olfa Nessibi

    2016-01-01

    Full Text Available Using bank level data this paper examines how bank’s specific characteristics and macroeconomic indicators affect the profitability in the Tunisian banking industry over the period 1990–2008. The results indicate that the more profitable banks are those higher amount of capital and lower operating costs. Furthermore, it appears that private banks tend to perform better than state owned ones.  Despite the great importance given to the board of directors, it doesn't have a dominant role in the Tunisian commercial banks. Finally, turning to macroeconomic conditions and its impact on banks’ profitability, we find that the real interest rate has a positive effect on bank profitability.

  9. Uncompensated care provided by for-profit, not-for-profit, and government owned hospitals.

    Science.gov (United States)

    Cram, Peter; Bayman, Levent; Popescu, Ioana; Vaughan-Sarrazin, Mary S; Cai, Xueya; Rosenthal, Gary E

    2010-04-07

    There is growing concern certain not-for-profit hospitals are not providing enough uncompensated care to justify their tax exempt status. Our objective was to compare the amount of uncompensated care provided by not-for-profit (NFP), for-profit (FP) and government owned hospitals. We used 2005 state inpatient data (SID) for 10 states to identify patients hospitalized for three common conditions: acute myocardial infarction (AMI), coronary artery bypass grafting (CABG), or childbirth. Uncompensated care was measured as the proportion of each hospital's total admissions for each condition that were classified as being uninsured. Hospitals were categorized as NFP, FP, or government owned based upon data obtained from the American Hospital Association. We used bivariate methods to compare the proportion of uninsured patients admitted to NFP, FP and government hospitals for each diagnosis. We then used generalized linear mixed models to compare the percentage of uninsured in each category of hospital after adjusting for the socioeconomic status of the markets each hospital served. Our cohort consisted of 188,117 patients (1,054 hospitals) hospitalized for AMI, 82,261 patients (245 hospitals) for CABG, and 1,091,220 patients for childbirth (793 hospitals). The percentage of admissions classified as uninsured was lower in NFP hospitals than in FP or government hospitals for AMI (4.6% NFP; 6.0% FP; 9.5% government; P NFP; 3.3% FP; 7.0% government; P NFP; 4.2% FP; 11.8% government; P NFP and FP hospitals (4.4% vs. 4.3%; P = 0.71), and higher for government hospitals (6.0%; P NFP vs. government). Likewise, results demonstrated similar proportions of uninsured patients in NFP and FP hospitals and higher levels of uninsured in government hospitals for both CABG and childbirth. For the three conditions studied NFP and FP hospitals appear to provide a similar amount of uncompensated care while government hospitals provide significantly more. Concerns about the amount of

  10. IMPROVING HUMAN RESOURCES REPORTING IN NON FOR PROFIT ORGANIZATIONS

    OpenAIRE

    Nicolae Todea1; Delia Corina Mihaltan2

    2013-01-01

    The paper aims to expose the present reality concerning the information offered byaccounting regarding the human resources in a non for profit organization and to propose ways ofimproving it. To this end we display the typical aspects of human resources which are connected tothe specificities of the non for profit organizations and their impact on accounting. We emphasizethe deficiencies of human resources reporting and submit means of improving it.

  11. What Do We Know About Variance in Accounting Profitability?

    OpenAIRE

    Anita M McGahan; Porter, Michael E.

    2002-01-01

    In this paper, we analyze the variance of accounting profitability among a broad cross-section of forms in the American economy from 1981 to 1994. The purpose of the analysis is to identify the importance of year, industry, corporate-parent, and business-specific effects on accounting profitability among operating businesses across sectors. The findings indicate that industry and corporate-parent effects are important and related to one another. As expected, business-specific effects, which a...

  12. Non-profit organization as a category of political science

    Directory of Open Access Journals (Sweden)

    Mukhametov Ruslan Salikhovich

    2016-07-01

    Full Text Available The article is devoted to theoretical and methodological study of non-profit organizations. The author proposes to distinguish the concept of “non-governmental organization” and “non-profit organization” (NPO. The article outlines the main features of the NPO. A lot of attention is paid to the typology of these organizations. The author gave an exhaustive scientific analysis of the forms of NPO activities.

  13. sustainable development and profitability in the Finnish restaurant industry

    OpenAIRE

    Mulenga, Mpafya

    2015-01-01

    Environmental sustainability in the food industry is often concerned with the provision of organic products and recycling. The emphasis on organically produced supplies though viewed as an environmentally sustainable means of food production to meet the ends of the green revolution should not obscure consideration of profitability in the business. Making profit is a business goal, while environmental sustainability is an ethical issue whose practice is subject to the balancing act of being pr...

  14. Sustainability and Counteracting Factors to Profit Rate Decline

    DEFF Research Database (Denmark)

    Ougaard, Morten

    2014-01-01

    This paper discusses sustainability implications of barriers to growth as specified in the theory of the long-term falling rate of profit but focusing on the counteracting factors (CFs) specified by Marx. These depend much on political processes and are important in state theory for understanding...... which implies a destruction of capital that will counteract the falling rate of profit. This will require sustained political intervention....

  15. Pricing, Profits, and Technological Progress in the Pharmaceutical Industry

    OpenAIRE

    Scherer, F. M.

    1993-01-01

    The decades-old debate over pharmaceutical industry prices, profits, and innovation has again intensified. A number of events coalesced to refocus public interest on pharmaceuticals. Contributing to public concern were Bureau of Labor Statistics price index increases for pharmaceuticals far outpacing those for the products of other industries. Another prominent characteristic of the pharmaceutical industry has been its extraordinarily high reported profitability. This article examines the phe...

  16. Persistence of Profitability in Family-Owned Food Businesses

    OpenAIRE

    Michael A. Boland; Pendell, Dustin L.

    2005-01-01

    We examine firm profitability in the food economy and determine the source of variance of firm profitability in family-owned and non-family-owned food processing firms. The results indicate firm effects dominate in explaining the variance in the business-segment performance in the food economy. More specifically, we find family-owned firms compared to non-family-owned firms have a higher percentage of total variance in the business-segment performance explained by yearly effects, industry eff...

  17. Relationship between Non-current Assets & Firms Profitability

    OpenAIRE

    Iqbal, Athar; mati, madhu

    2012-01-01

    The current study examines the relation between capital еxpеnditurе and earnings of the companies which are non-financial. The scope of research is related to the firm’s profitability and the relationship with the noncurrent assets as managing working capital and capital expenditure efficiently affects the profitability of the firm. Last ten years data of non – financial firms listed at KSE 100 index was taken. It includes Cement, Manufacturing, Engineering, Chemical, Paper, Sugar, Textile, T...

  18. Determinants of bank profitability: evidence from CreditCoop

    OpenAIRE

    Ioana-Raluca DIACONU; Oanea, Dumitru-Cristian

    2014-01-01

    Co-operative banks were not analyzed in great detail in the literature compared to credit unions or even commercial banks. Through this paper we want to identify the main determinants of CreditCoop profitability, determinants: internal determinants (result of bank management) and external determinants (macroeconomic and industry variables). We found that the loan to assets ratio and equity to assets ratio have the highest and significant impact over the CreditCoop profitability. Moreover, we ...

  19. Improving Gross Profit Margin in a quick service restaurant

    OpenAIRE

    Heino, Minna

    2015-01-01

    The purpose of this thesis is to try help implementing the corporate strategy in a quick service restaurant environment by offering practical examples. The objective is to improve the profitability of the case company by the management of the sales team. Questions to be answered are how the gross margin can be developed and what results can be gained. Some of the key concepts of this thesis are gross margin and sales management, restaurant profitability and implementing corporate strategy int...

  20. Profit and Risk Measures in Oil Production Optimization

    DEFF Research Database (Denmark)

    Capolei, Andrea; Foss, Bjarne; Jørgensen, John Bagterp

    2015-01-01

    In oil production optimization, we usually aim to maximize a deterministic scalar performance index such as the profit over the expected reservoir lifespan. However, when uncertainty in the parameters is considered, the profit results in a random variable that can assume a range of values dependi...... pro and cons for each of them. Finally, among the presented risk measures, we identify two of them as appropriate risk measures when minimizing the risk....

  1. Towards more profitable and sustainable milk and beef production system

    OpenAIRE

    Kokko, Pauliina

    2017-01-01

    Achieving and maintaining national self-sufficiency in milk and meat play important roles in ensuring future food security. Currently, Finland is self-sufficient in milk. However, beef production, which is strongly related to dairy production, has fallen below consumption mainly because of a decreased number of dairy cows and low profitability. Even though the efficiency and productivity in dairy herds have increased substantially during the last decades, the profitability of milk, and especi...

  2. Profit Sharing and Workplace Productivity: Does Teamwork Play a Role?

    OpenAIRE

    Long, Richard J.; Fang, Tony

    2013-01-01

    The conditions under which profit sharing affects workplace productivity have never been fully understood. Using panel data, this paper examines whether there is any link between adoption of an employee profit sharing plan and subsequent productivity growth in Canadian establishments, and whether this relationship is affected by various contextual factors, particularly use of work teams. In so doing, we use both three and five-year panels. Overall, we find a significant link between adoption ...

  3. Entry of Wal-Mart Supercenters and Supermarkets’ Profit Margins

    OpenAIRE

    Xiaoou Liu; Rigoberto A. Lopez

    2011-01-01

    This article quantifies the impact of Wal-Mart Supercenters on supermarkets’ profitability via a two-stage dynamic entry game, using method of simulated moments and milk scanner data from Dallas/Fort Worth supermarkets. The empirical findings show that the entry of Wal-Mart Supercenters accounts for about an average 50% decrease in milk profit margins for incumbent supermarkets. Effects of scale are found to be more significant for Wal-Mart Supercenters than for incumbent supermarkets, granti...

  4. Social media for non-profit organizations in Vietnam

    OpenAIRE

    Nguyen, Thy

    2016-01-01

    The thesis presents about social media in general and social media for non-profit organizations in Vietnam in particular. The writer wanted to explore the disadvantages that non-profits in Vietnam face when using social media and search for recommendations which helps them to use it more efficiently. In the theoretic part, core concepts related to social media were introduced, namely, definition of social media, its types, the popular platforms, situation of social media in Vietnam, pros...

  5. Economic values for production and functional traits of Small East African goat using profit functions.

    Science.gov (United States)

    Mbuku, Samuel; Kosgey, Isaac; Okeyo, Mwai; Kahi, Alexander

    2014-06-01

    Economic values for production traits (milk yield, MY, g; 12-month live weight, yLW, kg; consumable meat percentage, CM, %) and functional traits (mature doe live weight, DoLW, kg; mature buck live weight, LWb, kg; kidding frequency, KF; pre-weaning survival rate, PrSR, %; post-weaning survival rate, PoSR,%; doe survival rate, DoSR, %; and residual feed intake, RFI, kg) were estimated using profit functions for the Small East African goat. The scenario evaluated was a fixed flock size, and the resultant economic values (Kes per doe per year) were 34.46 (MY), 62.35 (yLW), 40.69 (CM), 0.15 (DoLW), 2.84 (LWb), 8.69 (KF), 17.38 (PrSR), 16.60 (PoSR), 16.69 (DoSR) and -3.00 (RFI). Similarly, the economic values decreased by -14.7 % (MY), -2.7 % (yLW), -23.9 % (CM), -6.6 % (DoLW), -98 % (LWb), -8.6 % (KF), -8.2 % (PrSR), -8.9 % (PoSR), -8.1 % (DoSR) and 0 % (RFI) when they were risk rated. The economic values for production and functional traits, except RFI, were positive, which implies that genetic improvement of these traits would have a positive effect on the profitability in the pastoral production systems. The application of an Arrow-Pratt coefficient of absolute risk aversion (λ) at the level of 0.02 resulted in a decrease on the estimated economic values, implying that livestock keepers who were risk averse were willing to accept lower expected returns. The results indicate that there would be improvement in traits of economic importance, and, therefore, easy-to-manage genetic improvement programmes should be established.

  6. Using System Architecture Maturity Artifacts to Improve Technology Maturity Assessment

    Science.gov (United States)

    2012-03-01

    implementation as they mature over time, which enable and support operational requirements [7]. In the latest version of DoDAF, Meta Model ( DM2 ) have been...Conceptual Data Model (CDM), which is one of the new three levels of DoDAF Meta Models ( DM2 ) introduced in DoDAF 2.0. The CDM defines concepts involving...collection and usage of architecture related data. Figure 1: Most popular DM2 Conceptual Data Model concepts used for categorizing maturity

  7. The Impact of Internal Factors on Bank Profitability in Kosovo

    Directory of Open Access Journals (Sweden)

    Leonora Haliti Rudhani

    2016-02-01

    Full Text Available Commercial banks play an important role in the economic development and financial stability; therefore this study investigated the influence of internal factors in the profitability of commercial banks in Kosovo. Based on the literature review, a crucial internal factor on the profitability of banks in Kosovo was deemed: the repayment of assets (ROA as a measure of profitability influenced by other independent variables, such as: bank size, capital adequacy, loan and liquidity risk. The aim of this study is to investigate the empirical relation between internal factors determining bank profitability and profitability as a dependent variable. The empirical analysis is based on the data of commercial banks in Kosovo published in the period 2010-2014. The data were analysed with SPSS 21 version, and the hypotheses were tested by means of correlation and linear regression. The findings of the study proved that commercial banks in Kosovo could enlarge their profitability by increasing the level of bank loaning and other investments, except for managing risk and liquidity properly.

  8. Impact of Liquidity on Islamic Banks' Profitability: Evidence from Bangladesh

    Directory of Open Access Journals (Sweden)

    Limon Moinur Rasul

    2013-04-01

    Full Text Available This study examines the impact of liquidity on Islamic banks’ profitability during an 11 years period of 2001 to 2011. To explore and interpret the results the study has taken samples from five Islamic banks that have been in operation in Bangladesh on or before 2001 to till date. In order to construct the liquidity model it used four liquidity variables namely cash & due from banks to total assets (CDTA, cash & due from banks to total deposits (CDDEP, investment to total assets (INVSTA and investment to total deposits (INVSDEP. According to adjusted R squares profitability variables return on assets (ROA, return on equity (ROE and return on deposits (ROD are respectively 17.1%, 4.5% and 24.6% dependent on independent variables. The statistical results suggest that CDTA is found insignificant with all profitability variables, whereas CDDEP is individually significant with all profitability variables except ROE. On the other hand INVSTA and INVSDEP are recognized significant with all three profitability variables. However, when ROE stands for an insignificant relationship with the overall liquidity model, ROA and ROD are identified significantly correlated with the similar model at 1% significant level. Unsurprisingly the findings do strengthen the specification that the impact of liquidity reflects adequate imposition on profitability that the Islamic banks in Bangladesh must abide by.

  9. Capital Structure and Profitability of Quoted Companies in Nigeria

    Directory of Open Access Journals (Sweden)

    AMOS O. AROWOSHEGBE. Ph.D; ACA.

    2013-07-01

    Full Text Available The study examined the relationship of capital structure to profitability of quoted firms in Nigeria. The study was based on a panel data set from 1996 to 2010 comprising sixty non – financial companies. The study specified two panel regression models. Two profitability measures: Net Profit Margin (NPM and Operating Profit Margin (OPM were taken as the dependent variables respectively. The principal explanatory variable for each of the models was Debt Ratio (DR. The results of the study indicated that there was a significant negative relationship between capital structure and profitability of quoted companies in Nigeria. Indeed, the results the Pecking order theory that profitable firms do not target an optimal level of leverage to balance the benefits and costs of debt financing. Rather, firms use retained earnings first, then debts and finally equity. Such firms would actually be paying high tax charges and also high operating costs arising from over dependence on the money market for their funds requirements. It was recommended that appropriate fiscal policies, relevant capital market institutional and legal framework should be put in place. These measures, we believe, will ensure better access to funds and reduce the cost of doing business.

  10. Delayed visual maturation and autism.

    Science.gov (United States)

    Goodman, R; Ashby, L

    1990-09-01

    Three boys are described with a mixed developmental disorder, which so far appears to have a relatively good prognosis. Each boy presented in early infancy with visual unresponsiveness, which spontaneously resolved. This delayed visual maturation was accompanied or followed by severe autistic impairment, general developmental delay, hypotonia and clumsiness. Subsequent progress has been unexpectedly favourable, with striking improvements in language, play, social interest and social competence. Widespread, patchy delay in brain maturation could possibly account for this combination of delayed visual maturation and autism, with a good prognosis.

  11. Cause Related Marketing: Consumers Perceptions and Benefits for Profit and Non-Profits Organisations

    Directory of Open Access Journals (Sweden)

    Francisca Farache

    2008-07-01

    Full Text Available This study is an attempt to understand consumers’ perceptions regarding Cause Related Marketing [CRM]. The research findings were based on a survey of 200 consumers in the Brighton area and published data. The research aim was focused on the consumers’ perception of the alliance between corporations and non-profit organisations. The research found that consumers have a better perception of firms that work with charities and good causes than those that do not. They believe that the partnership between corporations and charities has an impact on the good of society. However, they are aware that corporations themselves benefit from this partnership. Concerning good causes, consumers prefer to support those related to Children. The researchers noticed that an individual connection with a cause might have considerable influence on consumer attitudes and behaviour in relation to a specific cause.

  12. THE EFFECT OF WORKING CAPITAL ON THE PROFITABILITY OF PALM OIL PLANTATION COMPANIES

    Directory of Open Access Journals (Sweden)

    Tania Prafitri

    2017-05-01

    Full Text Available Management decisions related to working capital are based on the management of short-term assets and liabilities, aiming to ensure that the company is able to maintain the operations and have sufficient cash flows to finance short-term debt maturities and operational costs, as well as to improve the profitability of the company. The objective of this study is to examine the effect of working capital management on company profitability. Working capital is considered to be an important issue in financial management and have an effect on liquidity as well as on the company profitability. In addition, optimized working capital management contributes greatly to the achievement of company objectives. The secondary data were taken from the annual reports of 6 oil palm plantation companies registered in the Indonesia Stock Exchange (IDX during the year 2009-2015. Profitability as a dependent variable was measured by return on investment (ROI. Cash conversion cycle (CCC, current ratio (CR, financial debt ratio (FDR, and fixed financial asset ratio (FFAR are independent variables. The analytical model used in this study was panel regression by using Fixed Effect Model. The results showed that there is a negative effect of working capital on profitability. Profitability will increase as cash cycle conversion cycle decreases. This is because companies with short cash conversion cycle are able to collect the cash needed for the company's day-to-day operations.Keywords: working capital, cash conversion cycle, current ratio, debt ratio, fixed assets ratio. profitabilityABSTRAKKeputusan manajemen yang berkaitan dengan modal kerja didasari oleh cara pengelolaan antara aset dan kewajiban jangka pendek, hal ini bertujuan untuk memastikan bahwa perusahaan mampu untuk melanjutkan kegiatan operasional dan memiliki arus kas yang cukup untuk membiayai hutang jangka pendek yang jatuh tempo dan biaya kegiatan operasional, serta untuk meningkatkan profitabilitas

  13. Costs, Commitment and Locality: A Comparison of For-Profit and Not-for-Profit Health Plans

    National Research Council Canada - National Science Library

    2004-01-01

    ...) (Schlesinger, Mitchell, and Gray 2003), this study of the New York state market shows significant differences in premiums, administrative overhead and commitment to safety net coverage between nonprofit and for-profit health plans...

  14. Slab replacement maturity guidelines : [summary].

    Science.gov (United States)

    2014-04-01

    Concrete sets in hours at moderate temperatures, : but the bonds that make concrete strong continue : to mature over days to years. However, for : replacement concrete slabs on highways, it is : crucial that concrete develop enough strength : within ...

  15. 7 CFR 51.1823 - Mature.

    Science.gov (United States)

    2010-01-01

    ... Standards for Grades of Florida Tangerines Definitions § 51.1823 Mature. Mature shall have the same meaning... the Florida Citrus Industry, in effect as of February 12, 1995. These tangerine maturity requirements...

  16. Comparative proteomic exploration of whey proteins in human and bovine colostrum and mature milk using iTRAQ-coupled LC-MS/MS.

    Science.gov (United States)

    Yang, Mei; Cao, Xueyan; Wu, Rina; Liu, Biao; Ye, Wenhui; Yue, Xiqing; Wu, Junrui

    2017-09-01

    Whey, an essential source of dietary nutrients, is widely used in dairy foods for infants. A total of 584 whey proteins in human and bovine colostrum and mature milk were identified and quantified by the isobaric tag for relative and absolute quantification (iTRAQ) proteomic method. The 424 differentially expressed whey proteins were identified and analyzed according to gene ontology (GO) annotation, Kyoto encyclopedia of genes and genomes (KEGG) pathway, and multivariate statistical analysis. Biological processes principally involved biological regulation and response to stimulus. Major cellular components were extracellular region part and extracellular space. The most prevalent molecular function was protein binding. Twenty immune-related proteins and 13 proteins related to enzyme regulatory activity were differentially expressed in human and bovine milk. Differentially expressed whey proteins participated in many KEGG pathways, including major complement and coagulation cascades and in phagosomes. Whey proteins show obvious differences in expression in human and bovine colostrum and mature milk, with consequences for biological function. The results here increase our understanding of different whey proteomes, which could provide useful information for the development and manufacture of dairy products and nutrient food for infants. The advanced iTRAQ proteomic approach was used to analyze differentially expressed whey proteins in human and bovine colostrum and mature milk.

  17. Patient experience and hospital profitability: Is there a link?

    Science.gov (United States)

    Richter, Jason P; Muhlestein, David B

    Patient experience has had a direct financial impact on hospitals since value-based purchasing was instituted by the Centers for Medicare & Medicaid Services in 2013 as a method to reward or punish hospitals based on performance on various measures, including patient experience. Although other industries have shown an indirect impact of customer experience on overall profitability, that link has not been well established in the health care industry. Return-to-provider rate and perceptions of health quality have been associated with profitability in the health care industry. Our aims were to assess whether, independent of a direct financial impact, a more positive patient experience is associated with increased profitability and whether a more negative patient experience is associated with decreased profitability. We used a sample of 19,792 observations from 3767 hospitals over the 6-year period 2007-2012. The data were sourced from Centers for Medicare & Medicaid Services and Hospital Consumer Assessment of Healthcare Providers and Systems. Using generalized estimating equations to account for repeated measures, we fit four separate models for three dependent variables: net patient revenue, net income, and operating margin. Each model included one of the following independent variables of interest: percentage of patients who definitely recommend the hospital, percentage of patients who definitely would not recommend the hospital, percentage of patients who rated the hospital 9 or 10, and percentage of patients who rated the hospital 6 or lower. We identified that a positive patient experience is associated with increased profitability and a negative patient experience is even more strongly associated with decreased profitability. Management should have greater justification for incurring costs associated with bolstering patient experience programs. Improvements in training, technology, and staffing can be justified as a way to improve not only quality but now

  18. Determinants of profitability according to groups of banks in Albania

    Directory of Open Access Journals (Sweden)

    Dr.Sc. Arjeta Hallunovi

    2017-06-01

    Full Text Available The paper analyzed the determinants of profitability of all the commercial banks in Albania, where the banks were analyzed by dividing into groups[1]. These determinants are categorized into two groups, internal and external factors. The objective of the study is to determine the factors that affect the profitability in commercial banks, to show how they differ according to groups of the banks and making some recommendations which can help the management. A panel data with all the commercial banks that operate in Albania is analyzed for the period 2009-2014. To measure the profitability is used the independent variable return on assets. Banking specific factors that are used in this study include variables such as bank size, asset management, credit risk, liquidity of assets, capital adequacy, operational efficiency and cost of financing. On the other hand is taken into consideration only one industry specific factor, which is the concentration and some macroeconomic factors as GDP, exchange rate and inflation. The quantitative data are obtained from the financial statements of commercial banks, INSTAT, Bank of Albania, World Bank and Bankscope, in order to make empirical analysis needed to identify and measure the determinants of bank profitability. In particular, the multiple regression analysis is used to measure the impact of determinants in bank profitability and to realize empirical analysis is used Eviews 7. The results of the study showed a positive relationship between bank size and profitability, statistically important in the group 2, with 1% level of significance. The credit risk had an inverse relation with profitability in the model, statistically significant at 1% level of significance for the group 2 and 5% for the group 1 and 3. While, in terms of macroeconomic factors, GDP had a positive relationship with profitability and it is statistically significant in the group 3. On the other hand, inflation and exchange rate showed a

  19. Profit and loss account in the international context

    Directory of Open Access Journals (Sweden)

    PALIU - POPA LUCIA

    2011-06-01

    Full Text Available Given that the objective of financial statements is to provide information about the financial position, financial performance and cash flows of an economic unit, useful for a wide range of users in making economic decisions, particular attention should be paid to the profit and loss account, which is the main instrument for reflecting the financial performance, because on the one hand it provides the information necessary for their evaluation, and on the other hand the information essential for determining the risk of cash flows. Even if each component of the financial statements provides different pieces of information, they should be correlated because they reflect different aspects of the same transactions or events, and in this article we will address the general aspects of profit and loss account from the perspective of profit and loss account models. In this regard, after a brief theoretical approach of the profit and loss account, we will indicate the advantages of two models of profit and loss account but without forgetting their limitations. Thus, we will provide the income statement structure on two stages of normalization: internationally and nationally.

  20. The importance of internal controls in profit centers

    Directory of Open Access Journals (Sweden)

    Ilić-Pupovac Maja

    2012-01-01

    Full Text Available Profit centers are relatively independent organization units within a company that realize revenues and expenditures whose numerical difference expresses the results they achieved. There are guided by basic mission and objectives of company, and profit centers managers are assigned to harmonize the business, motivate the employees, make decisions and implement actions that lead to increase of profitability and efficiency on the level of the whole company. In order to monitor the company development, financial statements are put together on the level of the profit center, and, on their basis, managers make decisions about further steps of company's growth and development. Since financial statements play significant role in company's further business operations, it is necessary to form and implement internal control system that can confirm reliability of profit centers financial statements with a great certainty. Internal control examines compliance with current policies and procedures, detects errors and abuses, and checks the accuracy and completeness of accounting records. The purpose of internal controls is to increase company's business efficiency, basing the decision making on timely and accurate information.

  1. Pricing strategies and levels and their impact on corporate profitability

    Directory of Open Access Journals (Sweden)

    Deonir De Toni

    Full Text Available Abstract Price policy definition is one of the most important decisions in management as it affects corporate profitability and market competitiveness. Despite the importance that prices take in organizations, it appears that this element has not received proper attention by many academics and marketers since it represents, according to estimates, less than 2% of the papers on leading journals in the field. Thus, the aim of this study was to propose and test a theoretical model showing the impacts of pricing policy on corporate profitability. To this end, 150 companies in the metal-mechanic sector situated in the Northeast of Rio Grande do Sul State, Brazil were studied, integrating customer value-based pricing strategies, competition-based pricing strategies and cost-based pricing strategies with price levels (high and low and performance with respect to profitability. The results indicate that the profitability of the surveyed companies is positively affected by value-based pricing strategy and high price levels while it is negatively affected by low price levels. Such findings indicate that pricing policies influence the profitability of organizations and therefore, a more strategic look at the pricing process may constitute one aspect that cannot be overlooked by managers.

  2. The impact of profitability of hospital admissions on mortality.

    Science.gov (United States)

    Lindrooth, Richard C; Konetzka, R Tamara; Navathe, Amol S; Zhu, Jingsan; Chen, Wei; Volpp, Kevin

    2013-04-01

    Fiscal constraints faced by Medicare are leading to policies designed to reduce expenditures. Evidence of the effect of reduced reimbursement on the mortality of Medicare patients discharged from all major hospital service lines is limited. We modeled risk-adjusted 30-day mortality of patients discharged from 21 hospital service lines as a function of service line profitability, service line time trends, and hospital service line and year-fixed effects. We simulated the effect of alternative revenue-neutral reimbursement policies on mortality. Our sample included all Medicare discharges from PPS-eligible hospitals (1997, 2001, and 2005). The results reveal a statistically significant inverse relationship between changes in profitability and mortality. A $0.19 average reduction in profit per $1.00 of costs led to a 0.010-0.020 percentage-point increase in mortality rates (p profitable. Policy simulations that target service line inequities in payment generosity result in lower mortality rates, roughly 700-13,000 fewer deaths nationally. The policy simulations raise questions about the trade-offs implicit in universal reductions in reimbursement. The effect of reduced payment generosity on mortality could be mitigated by targeting highly profitable services only for lower reimbursement. © Health Research and Educational Trust.

  3. IS THE PRICE RIGHT? PRICING FOR LONG TERM PROFITABILITY

    Directory of Open Access Journals (Sweden)

    Andrea Erika NYÁRÁDI

    2007-01-01

    Full Text Available The way how we choose our pricing strategy has a significant impact on company’s success. Nowadays companies more and more adopt a new way of thinking in pricing, namely pricing for a long term period in order to bring higher profitability, to build an efficient pricing strategy. Marketers have only recently begun to focus seriously on effective pricing. These companies are the so called progressive companies. They have begun doing more than just worrying about pricing. To increase profitability many are abandoning traditional reactive pricing procedures in favor of proactive pricing, making explicit corporate decisions to change their focus to growth in top-line sales to growth in profitability. The long-term implications of price strategies are still under-researched, and managers should be aware of shifts in customer reactions that may result from frequent adoption of certain strategies. The company pricing strategy should be seen in relation to developments in the company variables, internal ones (capital strength, competencies, organizational conditions, efficiency of the work force etc. as well as external ones (customers, competitors, the technological development etc., adopting strategic pricing. In this paper I will present the most effective pricing strategies leading to long term profitability, and also suggest practical conditions for pricing strategies to maximize profit in the long run.

  4. Capital structure and profitability. A case of JSE Listed Companies.

    Directory of Open Access Journals (Sweden)

    Faith Mashavave

    2015-03-01

    Full Text Available The research aims to find out the relationship between capital structure and profitability focusing on firms listed on the Johannesburg stock exchange in South Africa. Past research on this topic excluded the Johannesburg Stock Exchange listed firms. The research results will be useful to the business people in South Africa because it will be more in line with the South African economic status and thus relevant. From the graphs and tables of the companies analyzed, it appears there is no relationship between the capital structure and profitability. The fluctuations in the debt/equity ratio and profitability ratio are so severe to such an extent that no meaningful conclusion regarding the relationship between capital structure and profitability can be made. The outcomes are haphazard there is no uniformity and consistence on the outcomes. Other hindrances to the relationship between capital structure and profitability were also discovered and these were attributed to the environmental factors of the company such as economic, political, and social and all other external forces that companies under study were exposed to.

  5. Domestic and Foreign Banks’ Profitability: Differences and Their Determinants

    Directory of Open Access Journals (Sweden)

    Muhammad AZAM

    2012-01-01

    Full Text Available The purpose of this study to analyze and compare the profitability of domestic (Public & Private and foreign banks operating in the Pakistan Banking market between 2004 and 2010 on quarterly basis. Total 36 Commercial Banks of Pakistani Industry have represented our sample. To control for the effect of bank ownership on performance, we split the sample into three categories: (1 domestic banks with Government Control, (2 domestic banks with Private control, and (3 foreign banks. This study also finds that foreign banks are more profitable than all domestic banks regardless of their ownership structure by applying regression analysis. This may suggest that it is better for a multinational bank to establish a subsidiary/branch rather than acquiring an “existing player” in the host country. We also found that domestic and foreign banks have different profitability determinants, i.e. factors that are important in shaping domestic banks’ profitability are not necessary important for the foreign banks and vice versa. Empirical results show that foreign banks are less affected by the macroeconomic factors of the host country than domestic banks and they have a higher profitability margin in Pakistan.

  6. Net profit flow per country from 1980 to 2009 : The long-term effects of foreign direct investment

    NARCIS (Netherlands)

    Akkermans, Dirk H.M.

    2017-01-01

    Aim of the paper The paper aims at describing and explaining net profit flows per country for the period 1980-2009. Net profit flows result from Foreign Direct Investment (FDI) stock and profit repatriation: inward stock creating a profit outflow and outward FDI stock a profit inflow. Profit flows,

  7. Application of risk-rated profit model functions in estimation of economic values for indigenous chicken breeding.

    Science.gov (United States)

    Okeno, Tobias O; Magothe, Thomas M; Kahi, Alexander K; Peters, Kurt J

    2012-08-01

    The economic values for productive (egg number, average daily gain, live weight, and mature weight) and functional (fertility, hatchability, broodiness, survival rate, feed intake, and egg weight) traits were derived for three production systems utilizing indigenous chicken in Kenya. The production systems considered were free-range, semi-intensive, and intensive system and were evaluated based on fixed flock size and fixed feed resource production circumstances. A bio-economic model that combined potential performances, feeding strategies, optimum culling strategies, farmer's preferences and accounted for imperfect knowledge concerning risk attitude of farmers and economic dynamics was employed to derive risk-rated economic values. The economic values for all the traits were highest in free-range system under the two production circumstances and decreased with level of intensification. The economic values for egg number, average daily gain, live weight, fertility, hatchability, and survival rate were positive while those for mature weight, broodiness, egg weight, and feed intake were negative. Generally, the economic values estimated under fixed feed resource production circumstances were higher than those derived under fixed flock size. The difference between economic values estimated using simple (traditional) and risk-rated profit model functions ranged from -47.26% to +67.11% indicating that inclusion of risks in estimation of economic values is important. The results of this study suggest that improvement targeting egg number, average daily gain, live weight, fertility, hatchability, and survival rate would have a positive impact on profitability of indigenous chicken production in Kenya.

  8. The Profit Distribution of Supply Chain under E-Commerce

    Directory of Open Access Journals (Sweden)

    Jiang-Hua Zhang

    2014-01-01

    Full Text Available With the development of e-commerce, its influence on supply chain and supply chain management is becoming increasingly significant too. In this paper, the literature on the supply chain profit is reviewed first, and then a two-level and four-party supply chain which consists of a supplier, an e-commerce platform, third-party logistics, and demander is taken into consideration. The profit function of supply chain under e-commerce is formulated by taking the price of product and the maximum supply amount under certain investment as decision-making variables and taking the expected value of random variables of price as the setting sales quantity. Finally, the existence of maximum profit in the supply chain is proved in the model, and the coordination of supply chain under e-commerce environment can be achieved by setting coordination parameters when the relevant cost parameters of supply chain members satisfy certain conditions.

  9. Industrial management- control and profit a technical approach

    CERN Document Server

    Halevi, Gideon

    2014-01-01

    This volume presents controlling tools for management in order to be in a position to communicate with control engineers concerning technological decisions. The main objective of manufacturing management is to make profit. However, in traditional manufacturing systems none of the separate stages in the process support this objective. Management is not expert in any of these stages, and therefore is dependent on specific experts at each stage and must follow their decisions. Each stage has its own first priority which is not profit and cost. This means that management does not have real control over these functional stages, nor over the process as a whole. This book presents controlling tools for management in order to allow them to communicate better with the experts of the particular manufacturing stages to reach better results and higher profits. It is shown that most enterprises can improve their efficiency rate by between 25 and 60% by using the tools developed here.

  10. Konsep Perjanjian Profit and Loss Sharing dalam Ekonomi islam

    Directory of Open Access Journals (Sweden)

    Fahrurrozi Fahrurrozi

    2016-12-01

    Full Text Available Agreements of Profit and Loss Sharing is an agreement based on the confidence (trust investment, in another sense that financiers or Shahibul Mall will deliver the funds to the fund manager or mudharib after investors feel confident that the managers of these funds both skill and moral can be trusted to manage the capital provided by the expertise and capital will not manipulate it. With this fact it is necessary to examine the concept of profit and loss sharing agreement, with the hope to find a concept that is based on the teachings of Islam. In this paper presents about the concept of Profit and Loss Sharing in the view of Islamic economics is based on the Qur'an and Hadith.

  11. The benefits of customer profitability analysis in the hospitality industry

    Directory of Open Access Journals (Sweden)

    Dragan Georgiev

    2017-03-01

    Full Text Available The article reveals the benefits of customer profitability analysis implementation according to the specifics of the hotel product and the state of the management accounting in hotels. On this basis is substantiated the necessity management accounting and information systems in the hotels to be anteriorly adapted and developed in relevance with the objectives and methodological tools of customer profitability analysis, while keeping their function in collecting information for operational revenues and costs by responsibility centers. A model for customer profitability analysis based on ABC method is proposed in this connection, providing an example to clarify its methodological aspects and benefits. The latter consist in providing information for the purposes of taking a variety of management decisions regarding costs, product mix, pricing, performance measurement and implementation of various marketing initiatives.

  12. Applicability of Investment and Profitability Effects in Asset Pricing Models

    Directory of Open Access Journals (Sweden)

    Márcio André Veras Machado

    2017-11-01

    Full Text Available This study aims to investigate whether investment and profitability are priced and if they partially explain the variations of stock returns in the Brazilian stock market, according to the Fama and French’s (2015 five-factor model. By using time series and cross-section regression, we found that book-to-market, momentum and liquidity are associated with stock returns whereas investment and profitability were not significant. We also found that there is no investment premium in Brazil. Therefore, motivated by the importance of B/M, momentum and liquidity to the Brazilian stock market, as well as by the poor performance of profitability and investment, we document that Keene and Peterson’s (2007 five-factor model is superior to all other models, especially the five-factor model by Fama and French (2015.

  13. Public Sector IS Maturity Models

    DEFF Research Database (Denmark)

    Zinner Henriksen, Helle; Andersen, Kim Normann; Medaglia, Rony

    2011-01-01

    Online applications and processing of tax forms, driver licenses, and construction permits are examples of where policy attention and research have been united in efforts aiming to categorize the maturity level of e-services. Less attention has been attributed to policy areas with continuous online...... citizenpublic interaction, such as in public education. In this paper we use a revised version of the Public Sector Process Rebuilding (PPR) maturity model for mapping 200 websites of public primary schools in Denmark. Findings reveal a much less favorable picture of the digitization of the Danish public sector...... compared to the high ranking it has received in the international benchmark studies. This paper aims at closing the gap between the predominant scope of maturity models and the frequency of citizen-public sector interaction, and calls for increased attention to the activities of government where the scale...

  14. Cheese maturity assessment using ultrasonics.

    Science.gov (United States)

    Benedito, J; Carcel, J; Clemente, G; Mulet, A

    2000-02-01

    The relationship between Mahon cheese maturity and ultrasonic velocity was examined. Moisture and textural properties were used as maturity indicators. The ultrasonic velocity of the cheese varied between 1630 and 1740 m/s, increasing with the curing time mainly because of loss of water, which also produced an increase of the textural properties. Because of the nature of low-intensity ultrasonics, velocity was better related to those textural parameters that involved small displacements. Ultrasonic velocity decreased with increasing temperature because of the negative temperature coefficient of the ultrasonic velocity of fat and the melting of fat. These results highlight the potential use of ultrasonic velocity measurements to rapidly and nondestructively assess cheese maturity.

  15. COSTS AND PROFITABILITY IN FOOD PROCESSING: PASTRY TYPE UNITS

    Directory of Open Access Journals (Sweden)

    DUMITRANA MIHAELA

    2013-08-01

    Full Text Available For each company, profitability, products quality and customer satisfaction are the most importanttargets. To attaint these targets, managers need to know all about costs that are used in decision making. Whatkind of costs? How these costs are calculated for a specific sector such as food processing? These are only a fewquestions with answers in our paper. We consider that a case study for this sector may be relevant for all peoplethat are interested to increase the profitability of this specific activity sector.

  16. ANALYSIS OF INCOMES, EXPENSES AND PROFITABILITY IN BANKS

    Directory of Open Access Journals (Sweden)

    MIRELA MONEA

    2011-01-01

    Full Text Available The paper is centered on presenting some aspects regarding incomes, expenses and results of commercial banks from Romanian banking system such as: income dynamics and structure, expenses dynamics and structure, a set of indicators which reflects the main banks performances. Discussion is focused on a comparative analysis between two commercial banks from Romanian banking system, taking into consideration date from a certain period of time. Profitability indicators are very usefully from banks management having an important informational value, the main discussion being focused on: return on assets, return on equity, net assets margin, rate of profit, equity multiplier, expenses to income ratio.

  17. The Determinants of Bank Profitability: The Case of Tunisia

    OpenAIRE

    Olfa Nessibi

    2016-01-01

    Using bank level data this paper examines how bank’s specific characteristics and macroeconomic indicators affect the profitability in the Tunisian banking industry over the period 1990–2008. The results indicate that the more profitable banks are those higher amount of capital and lower operating costs. Furthermore, it appears that private banks tend to perform better than state owned ones.  Despite the great importance given to the board of directors, it doesn't have a dominant role in the ...

  18. Fluctuations of company yearly profits versus scaled revenue: Fat tail distribution of Levy type

    OpenAIRE

    H. E. Roman; Siliprandi, R. A.; Dose, C.; Riccardi, C.; Porto,M.

    2008-01-01

    We analyze annual revenues and earnings data for the 500 largest-revenue U.S. companies during the period 1954-2007. We find that mean year profits are proportional to mean year revenues, exception made for few anomalous years, from which we postulate a linear relation between company expected mean profit and revenue. Mean annual revenues are used to scale both company profits and revenues. Annual profit fluctuations are obtained as difference between actual annual profit and its expected mea...

  19. Health and human services in an age of maturity.

    Science.gov (United States)

    Aldridge, M G

    1986-12-01

    Catholic health care organizations are experiencing a tension between evangelical mission and expanding competition in medical markets. For the voluntary, not-for-profit health and human services system to survive and grow, hospital communities must find new revenue sources that do not create dependence on state and federal monies. The United States entered the Age of Maturity in 1985 as the "baby boomers" born between 1945 and 1957 became 40 years old, requiring health care providers to begin to plan for their care in old age. This large aging population, combined with a longer life span for Americans, will put increased burdens on health care organizations, particularly for chronic care, up to the year 2020 or beyond. Changes in family structure and social networks will be necessary as more people care for older relatives. The ratio of nonworkers to workers will increase, further burdening national and state tax bases, Social Security, and other worker-contributor programs. Investment banks are one option to finance the older population's increased needs for health and human services. Investment banks are funded by donations from the private sector (local and national businesses), the public sector (state, national, and local agencies), and new for-profit ventures for older persons. The contributions themselves remain in a central fund, with only the interest generated being used to fund local organizations committed to financial self-sufficiency and to helping the elderly. Older persons will carry increased economic and political clout in the Age of Maturity and will constitute a large percentage of hospitals' business. Therefore hospitals will have to develop a strong market position among the elderly. They must consider integrating a new service mix of both health and human services. Candidates for new hospital services for the elderly include housing programs, long-term care and continuum of care programs, employment programs, retirement planning, estate

  20. Fluid therapy in mature cattle.

    Science.gov (United States)

    Roussel, Allen J

    2014-07-01

    Fluid therapy for mature cattle differs from that for calves because the common conditions that result in dehydration and the metabolic derangements that accompany these conditions are different. The veterinarian needs to know which problem exists, what to administer to correct the problem, in what quantity, by what route, and at what rate. Mature cattle more frequently suffer from alkalosis; therefore, acidifying solutions containing K(+) and Cl(-) in concentrations greater than that of plasma are frequently indicated. The rumen provides a large-capacity reservoir into which oral rehydration solutions may be administered, which can save time and money. Copyright © 2014 Elsevier Inc. All rights reserved.

  1. 7 CFR 1421.101 - Maturity dates.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Maturity dates. 1421.101 Section 1421.101 Agriculture... Maturity dates. (a)(1) All marketing assistance loans shall mature on demand by CCC and no later than the... filed and disbursed except, for transferred marketing assistance loan collateral. The maturity date for...

  2. Maturity Models Development in IS Research

    DEFF Research Database (Denmark)

    Lasrado, Lester Allan; Vatrapu, Ravi; Andersen, Kim Normann

    2015-01-01

    Maturity Model (CMM). Only recently have there been some research efforts to standardize maturity model development. We also identify three dominant views of maturity models and provide guidelines for various approaches of constructing maturity models with a standard vocabulary. We finally propose using......Maturity models are widespread in IS research and in particular, IT practitioner communities. However, theoretically sound, methodologically rigorous and empirically validated maturity models are quite rare. This literature review paper focuses on the challenges faced during the development...... of maturity models. Specifically, it explores maturity models literature in IS and standard guidelines, if any to develop maturity models, challenges identified and solutions proposed. Our systematic literature review of IS publications revealed over hundred and fifty articles on maturity models. Extant...

  3. RADIO NOISE ADVANCES SEXUAL MATURITY

    African Journals Online (AJOL)

    ansistf-lewis

    Supplementary radio noise advances sexual maturity in domestic pullets exposed to 7-h photoperiods. P.D. Lewis. #. , B.A. Middleton. 1 and R.M. Gous. Animal and Poultry Science, School of Agricultural Sciences and Agribusiness, University of KwaZulu-Natal,. Scottsville 3209, South Africa. 1 School of Biomedical and ...

  4. Motivational Maturity and Helping Behavior

    Science.gov (United States)

    Haymes, Michael; Green, Logan

    1977-01-01

    Maturity in conative development (type of motivation included in Maslow's needs hierarchy) was found to be predictive of helping behavior in middle class white male college students. The effects of safety and esteem needs were compared, and the acceptance of responsibility was also investigated. (GDC)

  5. Fertilizer micro-dosing: a profitable innovation for Sahelian women ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    2016-06-06

    Fertilizer micro-dosing: a profitable innovation for Sahelian women. June 06, 2016. Ibro M Abdoulaye, Baco Mohamed Nasser, Badiori Ouatara, Sogodogo Diakalia, Mahaman Sabiou,Akponikpè PB Irenikatche, Derek Peak, Kimaro Anthony and Koala Saidou. The localized application of small quantities of fertilizer ...

  6. Coffee Production in Kigoma Region, Tanzania: Profitability and ...

    African Journals Online (AJOL)

    profitability in existing agricultural activities through agricultural transformation that focuses on investing in more productive technologies and efficient marketing ... only 0.25kg per tree of green coffee; the yields are among the lowest in the world). The study conducted by USAID (2010) in Kilimanjaro and Arusha revealed that ...

  7. Profit allocation among rational players in a cooperative game under ...

    Indian Academy of Sciences (India)

    negotiation via mediator. Math Forum Spl. 21: 33–40. Borkotokey S and Rupok Neog 2012 Allocating profit among rational players in a fuzzy coalition: A game theoretic model. Group Decis. Negot. 21: 439–459. Branzei R, Dimitrov D and Tijs S 2004 Hypercubes and compromise values for cooperative fuzzy games. Eur.

  8. analysis of profitability and poverty reduction of yoghurt processing ...

    African Journals Online (AJOL)

    Admin

    mostly males (70%) who were in their active age group of 36-45 years. Profitability analysis revealed that yoghurt ... 2007). Poverty, food insecurity and malnutrition are prevalent throughout Nigeria (Innovative .... Storage problem caused by the epileptic power supply in Maiduguri and improper packaging of products.

  9. Productivity and profitability of robusta coffee agroforestry systems in ...

    African Journals Online (AJOL)

    To contribute to understanding the socio-economic impact of shade trees and the returns from robusta coffee farming systems, this study compared the financial profitability of shaded coffee fields which are dependent on nutrient cycling to sustain production (traditional system) and shaded coffee fields where compost ...

  10. Profitability of sorghum-legume cropping practices among ...

    African Journals Online (AJOL)

    Mo

    Data collected was entered in SPSS and Excel computer soft ware for analysis. Gross margin was computed to determine the profitability of the intercrops and sole component crops. Gross margin was subjected to analysis of variance using SPSS and results showed that the gross margin of sorghum-cowpea and sorghum- ...

  11. A simple technique to increase profits in wood products marketing

    Science.gov (United States)

    George B. Harpole

    1971-01-01

    Mathematical models can be used to solve quickly some simple day-to-day marketing problems. This note explains how a sawmill production manager, who has an essentially fixed-capacity mill, can solve several optimization problems by using pencil and paper, a forecast of market prices, and a simple algorithm. One such problem is to maximize profits in an operating period...

  12. Risk Pricing and Profit Maximization of Insurance Companies ...

    African Journals Online (AJOL)

    Insurance companies continue to face intense pressure to improve performance, increase profitability, deliver superior customer service and increase shareholder returns. This is primarily due to the fact that operating efficiency is of particular interest for managers whose aim is to improve the performance of their firm and, ...

  13. Impacts of transportation on the profitability of sweet potato ...

    African Journals Online (AJOL)

    Transportation is an essential aspect of agricultural production. However, in many parts of Nigeria, bad transport system is still a problem of rural farmers. Therefore, this study seeks to examine the impacts of transportation on the profitability of sweet potato production in Kwara State. The sampling techniques involved the ...

  14. The performance and profitability of sweet potato ( Ipomoea batatas L.)

    African Journals Online (AJOL)

    This study was conducted in 2013 and 2014 at the Teaching and Research Farm of the Faculty of Agriculture, University of Benin, Benin City, Nigeria. The aim of the study was to evaluate the effect of propagule length and cattle dung application rates on the growth, yield and profitability of sweet potato (Ipomea batatas L.) in ...

  15. Profitability of poultry production among school leavers in Anaocha ...

    African Journals Online (AJOL)

    The study was undertaken to investigate the profitability of poultry production in Anaocha Local Government Area of Anambra State, Nigeria. Ten poultry farmers were randomly drawn from each of the ten autonomous communities that make up the local Government Area to give a sample size of one hundred. Structured ...

  16. Le microdosage des engrais, une innovation qui profite aux femmes ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Le microdosage des engrais, une innovation qui profite aux femmes du Sahel. 06 juin 2016. Ibro M Abdoulaye, Baco Mohamed Nasser, Badiori Ouatara, Sogodogo Diakalia, Mahaman Sabiou,Akponikpè PB Irenikatche, Derek Peak, Kimaro Anthony et Koala Saidou. Grâce à l'application localisée de petites quantités ...

  17. Profitability of soil erosion control technologies in eastern Uganda ...

    African Journals Online (AJOL)

    For example, for every US$ invested per hectare in terracing and tree planting, there is a return of over US$ 15. However, these returns are likely to be much less if inflation is not regulated. For example, the profits expected from the use of terraces and trees would reduce by about 3 percent if inflation rose to 30 percent.

  18. Profitability Assessment Of Tomato And Pepper Produced Under ...

    African Journals Online (AJOL)

    The profitability of tomato and pepper produced under fadama development programme was investigated. A combination of primary and secondary data were used for the investigation. Simple descriptive statistics and farm budgeting techniques were used for the analysis. Results show that the total production cost per ...

  19. Marketing functions and determinants of profit among frozen chicken ...

    African Journals Online (AJOL)

    This study attempted to estimate the cost of performing some functions in frozen chicken marketing and determined the major factors affecting the profit level of the marketers. Using data collected from 10 wholesalers and 29 retailers in Ibadan metropolis, the transportation costs per kilogram of frozen chicken were N1.20 ...

  20. A Short Integrated Presentation of Valuation, Profitability and Growth Analysis

    DEFF Research Database (Denmark)

    Pettersson, Kim; Sørensen, Ole

    2016-01-01

    We demonstrate how the valuation models used in finance theory and the profitability and growth analysis taught in financial statement analysis are related. Traditional textbooks on finance and financial statement analysis are often very comprehensive, comprising a vast number of chapters. Howeve...

  1. Micro-Credit Access and Profitability on Crop Production in ...

    African Journals Online (AJOL)

    This study focused on the effect of micro-credit on the profitability of crop production in Orhionmwon Local Government Area of Edo State, Nigeria. A sample size of 166 small-scale farmers was randomly selected from the farming communities in Orhionmwon Local Government Area. Ninety two (92) beneficiaries and 74 ...

  2. Profitability of Small-Scale Fisheries in Elmina, Ghana

    Directory of Open Access Journals (Sweden)

    Isaac Okyere

    2012-10-01

    Full Text Available In order to achieve sustainable fishing livelihoods in coastal communities, data on profitability of small-scale fisheries relative to fish species caught and gear types used by fishermen is required as part of a broader fisheries management strategy. This study was undertaken with this in mind. Interviews were conducted among 60 fishermen between February and March 2010. Economic assessment of small-scale fishing activities were done using questionnaires based on direct market pricing and contingent valuation methods. The results indicate that highly profitable fish species include Epinephelus aeneus, Sparus caeruleostictus, Dentex angolensis and Lutjanus goreensis valued at US$2.97, US$2.87, US$2.85 and US$2.63 per kilogram respectively. The less profitable species include Dasyatis margarita, Caranx crysos and Sardinella aurita valued at US$0.34, US$0.66 and US$ 0.85 per kilogram respectively. Although Sardinella aurita was among the less valuable fish species, it was the main species driving profits for the fishermen due to its high share volume among the fish catches. Findings from this study suggest high rates of exploitation, in that stocks generally cannot provide for increased economic return in the face of increased investment. This is a clear indicator that the open-access nature of Ghanaian fisheries is not sustainable, and management reform is well overdue.

  3. Profitability of Minituber Seed Yam Production Technique in South ...

    African Journals Online (AJOL)

    An experiment was conducted at Umudike to evaluate the profitability of minituber production technique using selected improved white yam varieties developed in 2003 as a back up to the minisett technique. The three white yam varieties selected were TDr89/02677, TDr89/02665 and TDr89/02565 known for their high ...

  4. Profitability of Striga tolerant maize variety (Sammaz 17) amongst ...

    African Journals Online (AJOL)

    The study was conducted in Lapai, Niger State, North central Nigeria to determine the profitability of improved maize variety (SAMMAZ 17) in cooperative farmer's fields. Demonstration plots were cited in three cooperative farms where the improved variety and a local variety were planted. All agronomic practices were ...

  5. Maximum profitability as a criterion for optimisation of utilisation ...

    African Journals Online (AJOL)

    A technique is proposed for the formulation of a factor/product relationship between grazing days/hectare (ha) and liveweight gain/ha in order to relate maximum profitability to intensity of herbage utilisation in beef production systems in the False Thornveld of the Eastern Province. The technique is particularly attractive in ...

  6. Production performance and profitability analysis of small scale ...

    African Journals Online (AJOL)

    The purpose of this study was to conduct a descriptive survey to study production performance, profitability and constraints of small scale layer projects funded through CASP in Germiston Region, Gauteng Province. Data was collected using a well-structured questionnaire from 26 small scale layer producers using ...

  7. Influence of socio economic characteristics on profitability of yam ...

    African Journals Online (AJOL)

    The paper investigated the influence of socio economic characteristics on profitability of yam production in Etche local government area of Rivers State, Nigeria. Data were collected with the aid of structured questionnaire from 120 randomly selected yam farmers in the study area. Data analysis was by use of regression.

  8. Topsoil thickness and harvest management influence switchgrass production and profitability

    Science.gov (United States)

    Switchgrass (Panicum virgatum L.) is an attractive dual use forage and/or biomass crop option for eroded or marginal soils where corn (Zea mays L.) grain production often is not profitable. Topsoil thickness, especially above soils with a claypan, relates to crop productivity and nutrient removal an...

  9. Profitability and capacity utilization of rice milling enterprises in ...

    African Journals Online (AJOL)

    The study estimated profitability of rice milling enterprises and determined their mills' capacity utilization in Ondo State of Nigeria Data collected from 85 rice millers in eight Local Government Areas of the State were analysed, using simple proportions, budgetary techniques, financial ratios and ordinary least squares ...

  10. Perception Of Farmers About Profitability Of Vegetable Gardening ...

    African Journals Online (AJOL)

    This study assessed perception of farmers about profitability of vegetable gardening enterprise in Ahiazu Mbaise local government area of Imo state, Nigeria. A structured questionnaire was administered to 60 randomly selected farmers in the study area. Data collected were analysed using frequencies, percentages and ...

  11. Profitability And Resource Use Efficiency In Maize Production In ...

    African Journals Online (AJOL)

    The study examined profitability and resource-use efficiency in Maize Production in Kontagora Local Government Area of Niger State, Nigeria during 2007 cropping season. Primary data were collected and analyzed using farm budgeting techniques and Production Function Analysis. Results indicated that farmers realized ...

  12. The profitability and production of a beef herd on transitional ...

    African Journals Online (AJOL)

    The importance of containing costs through the optimal utilization of feed emphasizes the need to optimize, rather than maximize, the rate of reproduction. It is, however, unknown which lick supplementation regimen, provided to an extensive beef herd on mixed veld, could bring about the most profitable and efficient farming ...

  13. Measurement of the effectiveness of non-profit organizations

    Directory of Open Access Journals (Sweden)

    Gudz Petro Vasilovych

    2015-10-01

    Full Text Available The necessity of implementing evaluation of effectiveness in non-profit organizations activity is grounded in this article. Shown adaptation EERL approach based on result monitoring. Analyzed one of the activity effectiveness on the example of the civil organization. Evaluation of effectiveness is important as for organizations to improve their services as to present the results for audience.

  14. Response of strawberry quality and profitability to farmyard manure ...

    African Journals Online (AJOL)

    Quality of strawberries in the tropics is partly limited by poor soil fertility, while profitability of different nutrient management strategies has not been established. The present study determined the effect of 0, 18, 36, and 54 t/ha farmyard manure (FYM) and triple super phosphate (TSP), equivalent to 0, 17, 34 and 68 kg/ha ...

  15. Profitability Of Pineapple Marketing In Owerri, Imo State, Nigeria ...

    African Journals Online (AJOL)

    The study article examined the profitability of pineapple marketing in Owerri, Imo State, Nigeria. Owerri was purposively chosen because there are markets in the city where pineapple is traded and the inhabitants purchase and consume them. Data collected was from sixty randomly selected marketers of pineapple.

  16. Profitability Of Marketing African Bread Fruit ( Treculia africana ...

    African Journals Online (AJOL)

    The profitability of marketing of the seed of Treculia Africana was examined. The study was carried out in Ibadan metropolis. A multi-stage sampling technique was used in data collection. The first is the random selection of 10 major food markets in Ibadan metropolis. The second stage involved the selection of Ibo food ...

  17. Comparative profitability analysis of selected rainfed and irrigated ...

    African Journals Online (AJOL)

    Land, fertilizer and agrochemicals were significant at varying levels and positively related to profit. The study therefore recommends that more financial assistance in the form of credit should be given to farmers so as to expand their production. Also, a minimum guaranty price of the farm produce should be enforced.

  18. 26 CFR 1.482-6 - Profit split method.

    Science.gov (United States)

    2010-04-01

    ... Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED... relevant business activity will be a principal determinant of the allocation of functions and risks among... derived from the comparable profit split is affected by the quality of the data and assumptions used to...

  19. Increasing cropping system diversity balances productivity, profitability and environmental health

    Science.gov (United States)

    Balancing productivity, profitability, and environmental health is a key challenge for agricultural sustainability. Most crop production systems in the United States are characterized by low species and management diversity, high use of fossil energy and agrichemicals, and can have large negative im...

  20. Profitibility analysis of pilot plant utilizing waste cassava peels and ...

    African Journals Online (AJOL)

    Profitibility analysis of pilot plant utilizing waste cassava peels and pulp as substitute for maiz in in animal feed formulation. ... for production of over 2,000 kinds of products, for example, starch syrup, grape sugar, foodstuffs, modified starch, medicaments, cosmetics, shoe polish, dry battery and chemicals for floatation.

  1. smallholder farmers' use and profitability of legume inoculants

    African Journals Online (AJOL)

    ACSS

    Logit and tobit regression models were used to assess drivers of the inoculants use and gross margin analysis to examine profitability. The area under the crop, distance to local markets, knowledge of legume root nodules, education level, contacts with organisations promoting biological N fixation (BNF) technologies, group ...

  2. Profit of Tourism Companies and their Market Evaluation On ZSE

    Directory of Open Access Journals (Sweden)

    Penda Ivor Altaras

    2017-06-01

    Full Text Available The author of this paper presents a statistical analysis of data on realized profits of companies in the tourist sector, whose shares are listed on the Zagreb Stock Exchange and used for active trading. Data on the realized profit for the companies in accounting period 2010 - 2015 is correlated with the prices of shares. Based on the above obtained results about the direction and strength of this correlation the author concludes about the extent to which the market takes into account profit of the companies as a relevant indicator for investments. This information can be extremely significant because, on the one hand, it provides information about the functionality of the market as a comprehensive socio-economic mechanism that anticipates all the available information based on which the prices of the shares are created as a monetary expression of the presumed value of companies. On the other hand, this information tells us about the expectations of active market participants about the future development of the tourism sector, which already accounts for almost 20% of the Croatian GDP. In addition, the author examines what other explanations could be used for the part of variance which is not explained with the correlation between profit and price of shares.

  3. Profits or people? The informative case of alcohol marketing.

    Science.gov (United States)

    Casswell, Sally

    2014-11-28

    To analyse influence on alcohol marketing policy in New Zealand. Document and literature review. There is a powerful argument and popular support for restricting alcohol marketing but no significant policy action taken. Greater priority has been placed on the profits of influential corporations compared with protecting the health of future generations of New Zealanders.

  4. Assessing the suitability and profitability of the system of rice ...

    African Journals Online (AJOL)

    The results were significantly different at p = 0.05 for practices and location effects. The enriched ... The basic SRI without any organic matter raised paddy yields by 60 % over conventional methods, (3.2 and 2.0 t/ha, respectively). The number of ... Key Words : Suitability, profitability, organic matter, SRI, economic analysis.

  5. Consumer-driven profit maximization in broiler production and processing

    Directory of Open Access Journals (Sweden)

    Ecio de Farias Costa

    2004-01-01

    Full Text Available Increased emphasis on consumer markets in broiler profit-maximizing modeling generates results that differ from those by traditional profit-maximization models. This approach reveals that the adoption of step pricing and consideration of marketing options (examples of responsiveness to consumers affect the optimal feed formulation levels and types of broiler production to generate maximum profitability. The adoption of step pricing attests that higher profits can be obtained for targeted weights only if premium prices for broiler products are contracted.Um aumento na ênfase dada ao mercado de consumidores de carne de frango e modelos de maximização de lucros na produção de frangos de corte geram resultados que diferem daqueles obtidos em modelos tradicionais de maximização de lucros. Esta metodologia revela que a adoção de step-pricing e considerando opções de mercado (exemplos de resposta às preferências de consumidores afetam os níveis ótimos de formulação de rações e os tipos de produção de frangos de corte que geram uma lucratividade máxima. A adoção de step-pricing atesta que maiores lucros podem ser obtidos para pesos-alvo somente se preços-prêmio para produtos processados de carne de frango forem contratados.

  6. Profitability analysis of sustainable swine production in Abia State ...

    African Journals Online (AJOL)

    Profitability analysis of sustainable swine production in Abia State, Nigeria. NC Ehirim, SUO Onyeagocha, CA Emenyonu, SC Onyemauwa, OG Ugochukwu. Abstract. No Abstract. Animal Production Research Advances Vol. 4 (1) 2008: pp. 63-72. http://dx.doi.org/10.4314/apra.v4i1.36430 · AJOL African Journals Online.

  7. RELATION OF DRILLING CAPACITY TO MARKET AND PROFIT

    Directory of Open Access Journals (Sweden)

    Mladen Zelenika

    1994-12-01

    Full Text Available Owner of drilling rigs should employ highly professional officers, who are capable to manage profit-orientated operations at all stages and make accurate analyses of the next three questions: how to deploy drilling crews to achieve the highest financial result; which kinds of equipment are compatible and employable in profitable operations, and how to compute the requirement of each type of equipment, and the number of drilling crews for a defined period and region to have profitable service. This paper introduce an original mathematical model convenient to compute exact values needed for an answer on these three questions. Application of this model is obvious for research of the relationship among: (i performance and cost of available drilling rigs, (ii condition on the market, and (iii estimated profit. Utilization of this model is possible only if records of market conditions' data, and data relating to progress and cost of operations in different conditions are established. These records will facilitate accurate estimation of input parameters' values and computation of output parameters' values using the Mathematical Model. Results of these computation should give basic data Tor precise plan of operation, rentabili-ty, and figures to decide the strategy of Drilling Company's capacity development.

  8. Effectiveness and profitability of insecticide formulations used for ...

    African Journals Online (AJOL)

    To identify optimal pest control with lower economic risks to farmers, we investigated the effectiveness and profitability of different insecticides and insecticide formulations against bean fly (Ophiomyia spp.) and bean flower thrips (Megalurothrips sjostedtii). Two separate experiments were conducted during 2009 to 2012.

  9. Influence of agronomic practices on yield and profitability in kenaf ...

    African Journals Online (AJOL)

    Field trials were conducted in 2003 and 2004 at the Institute of Agricultural Research and Training, Ibadan (7o 38' N 3o 84' E), Nigeria to determine the influence of some agronomic practices on yield and profitability in kenaf bast fibre production. Three kenaf varieties, Cuba 108, Ifeken 400 and Ibadan local, were subjected ...

  10. Modeling of price and profit in coupled-ring networks

    Science.gov (United States)

    Tangmongkollert, Kittiwat; Suwanna, Sujin

    2016-06-01

    We study the behaviors of magnetization, price, and profit profiles in ring networks in the presence of the external magnetic field. The Ising model is used to determine the state of each node, which is mapped to the buy-or-sell state in a financial market, where +1 is identified as the buying state, and -1 as the selling state. Price and profit mechanisms are modeled based on the assumption that price should increase if demand is larger than supply, and it should decrease otherwise. We find that the magnetization can be induced between two rings via coupling links, where the induced magnetization strength depends on the number of the coupling links. Consequently, the price behaves linearly with time, where its rate of change depends on the magnetization. The profit grows like a quadratic polynomial with coefficients dependent on the magnetization. If two rings have opposite direction of net spins, the price flows in the direction of the majority spins, and the network with the minority spins gets a loss in profit.

  11. Production Cost Efficiency and Profitability of Abakaliki Rice in ...

    African Journals Online (AJOL)

    The study focused on the production cost efficiency and profitability of Abakaliki rice in Ihialia Local Government Area of Anambra State, Nigeria.. A random sampling technique was employed to select a total of 100 Abakaliki rice farmers from the study area. Data collection was achieved through the administration of ...

  12. Quantitative approaches for profit maximization in direct marketing

    NARCIS (Netherlands)

    van der Scheer, H.R.

    1998-01-01

    An effective direct marketing campaign aims at selecting those targets, offer and communication elements - at the right time - that maximize the net profits. The list of individuals to be mailed, i.e. the targets, is considered to be the most important component. Therefore, a large amount of direct

  13. A note on a profit maximizing location model

    NARCIS (Netherlands)

    S. Zhang (Shuzhong)

    1997-01-01

    textabstractIn this paper we discuss a locational model with a profit-maximizing objective. The model can be illustrated by the following situation. There is a set of potential customers in a given region. A firm enters the market and wants to sell a certain product to this set of customers. The

  14. Analysis of profitability and cost determinants of smallholder oil palm ...

    African Journals Online (AJOL)

    Oil palm processing is a source of livelihood to many people. The study analyzed cost determinants and profitability of smallholders' oil palm processors using traditional and improved processing technologies. A multistage sampling technique was used to select respondents. Data were collected through questionnaire; ...

  15. Technical efficiency and profitability of backyard poultry farming in ...

    African Journals Online (AJOL)

    Technical efficiency and profitability of backyard poultry farming in Ika South Local Government Area, Delta State, Nigeria. ... The study revealed that the sum of N57,897 was realized by the average backyard poultry farmer. Further investigation revealed that return on investment was N1.39. This implies that for every one ...

  16. Labour productivity and profitability in the Dutch flower trade

    NARCIS (Netherlands)

    J. van Dalen (Jan); A.R. Thurik (Roy)

    1991-01-01

    textabstractThis paper makes an attempt to illustrate the use of econometric models as frame of reference for diagnosing small firm performance. For this purpose, two models are developed explaining differences in labour productivity and profitability among Dutch flower exporters. In addition, we

  17. Earmarked Lottery Profits: A Good Bet for Education Finance?

    Science.gov (United States)

    Novarro, Neva K.

    2005-01-01

    This article studies the effects of earmarking state lottery profits for education. Because educational expenditures generally exceed the funds earmarked for education by a wide margin, nothing prevents state legislators from using earmarked funds to replace rather than augment funds that would have gone to education in the absence of earmarking.…

  18. The Morality of Profit In Business: Transforming Waste Into Wealth ...

    African Journals Online (AJOL)

    The main argument of this theoretical paper is that the pursuit of honest profits in a voluntary market exchange is not only moral but also ingrained in human nature, in that human beings pursue activities that benefit them and avoid those that cause them loss. Through an examination of the Kenyan business venture called ...

  19. Telehealth Business: Boom Times, but Profits May Wait.

    Science.gov (United States)

    Calandra, Robert

    2017-04-01

    What we have here is irrational telehealth exuberance. Investors are plowing millions into startups. And even though millennials could be eager adopters, these are still early days for the industry. It may take years-and some regulatory changes-for profits to materialize.

  20. Profitability Study of Hibiscus sabdariffa L. Production around ...

    African Journals Online (AJOL)

    Simple cost accounting method was employed to examine cost benefit of the plant. Net benefit and BCR of hibiscus production was used to determine profitability. The result shows that Production cost of Sudan type hibiscus is almost similar to Jamaican type except harvesting and post harvesting management cost ...

  1. Piggerywaste management and profitability of pig farming in Imo ...

    African Journals Online (AJOL)

    Data were analyzed using descriptive statistics, operating net returns and benefit cost ratio. Net profits of the different categories of pig farms based on their waste management systems were compared using ANOVA statistics. The result shows that 75% of the pig farms managed their waste by open dumping, produced an ...

  2. Queuing Models: A Tool For Assessing The Profitability Of Barbing ...

    African Journals Online (AJOL)

    The study considered small scale business as an option in reducing the unemployment rate in our society. The study uses queuing models to assess the profitability of barbing salon business in Agbor town of Delta State. The result of the study indicates that the distribution of inter-arrival times, service times, and waiting ...

  3. Promotion of Employee Ownership and Profit Sharing in Europe

    NARCIS (Netherlands)

    Nijs, W.F. de; Poutsma, F.; Doorewaard, J.A.C.M.

    1999-01-01

    This article presents the major findings of a research project for the European Union on the development of promotion of employee ownership and profit sharing, known as PEPPER schemes, and the diffusion of these schemes throughout Europe. Since the first PEPPER report in 1991, the general situation

  4. Profit efficiency among catfish farmers in Benue state, Nigeria | Tsue ...

    African Journals Online (AJOL)

    The policy implication of these findings is that profit inefficiency in catfish production can be reduced significantly overtime as the farmers get more experienced and a more conducive environment is created, to encourage more aged farmers to be involved in catfish production in a bid to alleviate poverty and food insecurity ...

  5. The effect of financial leverage on profitability of manufacturing ...

    African Journals Online (AJOL)

    For many years many studies have focused on the effect of financial leverage on firm performance and yet there has been no specific result that can be generalized regarding the extent of the relationship between financial leverage and firm performance. This study examines the effect of financial leverage on profitability of ...

  6. 14 CFR Section 7 - Chart of Profit and Loss Accounts

    Science.gov (United States)

    2010-01-01

    ... II carriers Group III carriers operating revenues and expenses Transport revenues: 01Passenger: 01... expense-net: 80.0Interest income 81 81 81 86.0Income from nontransport ventures 81 81 81 87.0Equity in... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Chart of Profit and Loss Accounts Section 7...

  7. Entrepreneuring in the Leisure Industry. Commitment beyond Profit.

    Science.gov (United States)

    Jamieson, Lynn

    1988-01-01

    The level of commitment beyond profit goals may be a means to explore successes or failures within the efforts of leisure industry entrepreneurs. A review of three case interviews suggests that leisure oriented businesses may function with unusually different goals than non-leisure oriented businesses. (IAH)

  8. Genetic relationship between feed efficiency and profitability traits in ...

    African Journals Online (AJOL)

    The aim of this study was to estimate genetic (co)variances to compare residual feed intake (RFI) and feed conversion ratio (FCR) with growth, reproductive and profitability traits measured in growth tests of young bulls. The heritability estimated for FCR was 0.34 and for RFI 0.31 with a genetic correlation estimate of 0.75 ...

  9. Comparative Analysis of Profitability of Layers Production in Esan ...

    African Journals Online (AJOL)

    Data collected were analyzed using Net Profit (NP), Gross Margin (GM), Benefit Cost Ratio (BCR), Rate of Return on Investment (RRI), Rate of Return on Fixed Cost (RRFC), Rate of Return on Variable Cost (RRVC) and Return per Naira invested (R/N) and . Results of the study showed that the business of layers production ...

  10. Profitability and viability analyses of small-holder cocoa production ...

    African Journals Online (AJOL)

    The data collected were analyzed using descriptive statistics, Benefit Cost Ratio and Net Present Value at 10% discount rate. Results show that cocoa production is profitable and viable in the study area. Also, the three management systems are efficient and practicable. The NPV for owner managed was highest showing ...

  11. To Mature or not to Mature: The Information Systems Conundrum

    Directory of Open Access Journals (Sweden)

    Carl Marnewick

    2013-12-01

    Full Text Available Research has been done within the South African information technology (IT industry over the last decade with regard to project management maturity (PMM and the impact it has on delivering information systems (IS projects successfully. The research was done to determine whether IS PMM per knowledge area has improved over the last decade. It investigates if there is a correlation between maturity levels and project success. Four independent surveys over the last decade focused on IS PMM and the longitudinal analysis provides a benchmark for whether IS PMM has increased or not. This article focuses on whether certain knowledge areas are more of a problem within the IT industry and to determine what the overall IS PMM is. The longitudinal analysis indicates trends and highlights areas of concern. It indicates that most IT companies are still operating at level 3 and that risk and procurement management are the knowledge areas of concern. A comparative analysis indicates that there is no difference between South African and international maturity levels. The results provide a South African perspective of IS PMM. It highlights that risk management is still a knowledge area that is neglected and that emphasis must be placed on managing risk within IT projects.

  12. Cervical vertebral maturation as a biologic indicator of skeletal maturity.

    Science.gov (United States)

    Santiago, Rodrigo César; de Miranda Costa, Luiz Felipe; Vitral, Robert Willer Farinazzo; Fraga, Marcelo Reis; Bolognese, Ana Maria; Maia, Lucianne Cople

    2012-11-01

    To identify and review the literature regarding the reliability of cervical vertebrae maturation (CVM) staging to predict the pubertal spurt. The selection criteria included cross-sectional and longitudinal descriptive studies in humans that evaluated qualitatively or quantitatively the accuracy and reproducibility of the CVM method on lateral cephalometric radiographs, as well as the correlation with a standard method established by hand-wrist radiographs. The searches retrieved 343 unique citations. Twenty-three studies met the inclusion criteria. Six articles had moderate to high scores, while 17 of 23 had low scores. Analysis also showed a moderate to high statistically significant correlation between CVM and hand-wrist maturation methods. There was a moderate to high reproducibility of the CVM method, and only one specific study investigated the accuracy of the CVM index in detecting peak pubertal growth. This systematic review has shown that the studies on CVM method for radiographic assessment of skeletal maturation stages suffer from serious methodological failures. Better-designed studies with adequate accuracy, reproducibility, and correlation analysis, including studies with appropriate sensitivity-specificity analysis, should be performed.

  13. Non Profit and For-Profit Higher Education Accreditation. Council for Higher Education Accreditation. Fact Sheet #7

    Science.gov (United States)

    Council for Higher Education Accreditation, 2012

    2012-01-01

    This fact sheet presents data provided to the Council for Higher Education Accreditation (CHEA) by accrediting organizations for accrediting activity during 2010-2011. It includes both Title IV and Non-Title IV institutions. Data are presented in the following categories: (1) Accrediting Organizations; (2) Fourteen Major For-Profit Higher…

  14. In California, not-for-profit hospitals spent more operating expenses on charity care than for-profit hospitals spent.

    Science.gov (United States)

    Valdovinos, Erica; Le, Sidney; Hsia, Renee Y

    2015-08-01

    In exchange for sizable tax exemptions, not-for-profit hospitals must engage in activities that meet the Internal Revenue Service's community benefit standard. The provision of charity care-free care to those unable to pay-can help meet that standard. Bad debt, the other form of uncompensated care, cannot be used to meet the standard, although Medicaid shortfalls can. However, the ACA lacks guidelines for providing charity care, and federal law sets no minimum requirements for community benefit activities. Using data from California, we examined whether the levels of charity and uncompensated care provided differed across general acute care hospitals by profit status and other characteristics during 2011-13. The mean proportion of total operating expenses spent on charity care differed significantly between not-for-profit (1.9 percent) and for-profit hospitals (1.4 percent), in contrast to the mean proportion spent on uncompensated care. Both types of spending varied widely across hospitals. Policy makers should consider measures that remove disincentives to meeting the persistent considerable need for charity care-for example, increasing supports to offset rising Medicaid shortfalls resulting from program expansion-and facilitate the tracking of ACA impacts on the distribution of charity care and uncompensated care delivery. Project HOPE—The People-to-People Health Foundation, Inc.

  15. Growth and profitability in small privately held biotech firms: preliminary findings.

    Science.gov (United States)

    Brännback, Malin; Carsrud, Alan; Renko, Maija; Ostermark, Ralf; Aaltonen, Jaana; Kiviluoto, Niklas

    2009-06-01

    This paper reports on preliminary findings on a study of the relationship of growth and profitability among small privately held Finnish Life Science firms. Previous research results concerning growth and profitability are mixed, ranging from strongly positive to a negative relationship. The conventional wisdom states that growth is a prerequisite for profitability. Our results suggest that the reverse is the case. A high profitability-low growth biotech firm is more probably to make the transition to high profitability-high growth than a firm that starts off with low profitability and high growth.

  16. Profitability of Technical Currency Speculation. The Case of Yen-Dollar Trading 1976-2007

    OpenAIRE

    Schulmeister, Stephan

    2008-01-01

    The paper investigates the profitability of 1,024 moving average and momentum models and their components in the yen-dollar market. It turns out that all models would have been profitable between 1976 and 2007. The models produce more single losses than single profits. At the same time, the size of the single profits is on average much higher than the size of single losses because profitable positions last two to six times longer than unprofitable positions. Hence, the profitability of techni...

  17. Green ICT Maturity Model for Czech SMEs

    Directory of Open Access Journals (Sweden)

    Alena Buchalcevova

    2015-01-01

    Full Text Available This paper presents a design of a Green ICT maturity model that is aimed at maturity assessment of a Green ICT capability in SMEs that figure as users of ICT services. Based on a literature review and internet search, six maturity models in the Green ICT area were detected and further analysed. Since these maturity models do not suit maturity assessment in non-ICT SMEs, a new Green ICT maturity model for SMEs was developed. This paper introduces the process of model development, description of the resulted model and evaluation of the model.

  18. Green ICT Maturity Model for Czech SMEs

    OpenAIRE

    Alena Buchalcevova

    2015-01-01

    This paper presents a design of a Green ICT maturity model that is aimed at maturity assessment of a Green ICT capability in SMEs that figure as users of ICT services. Based on a literature review and internet search, six maturity models in the Green ICT area were detected and further analysed. Since these maturity models do not suit maturity assessment in non-ICT SMEs, a new Green ICT maturity model for SMEs was developed. This paper introduces the process of model development, description o...

  19. Mature eosinophils stimulated to develop in human cord blood mononuclear cell cultures supplemented with recombinant human interleukin-5. Part I. Piecemeal degranulation of specific granules and distribution of Charcot-Leyden crystal protein.

    Science.gov (United States)

    Dvorak, A M; Furitsu, T; Letourneau, L; Ishizaka, T; Ackerman, S J

    1991-01-01

    Human cord blood mononuclear cells were cultured for 35 days in media containing recombinant human interleukin 5 (rhIL-5) supplemented with a fraction of the culture supernatant of phytohemagglutinin (PHA)-stimulated human T lymphocytes from which interleukin 2 (IL-2) was eliminated. Cultured cells were studied by electron microscopy and an immunogold procedure to detect subcellular site(s) of Charcot-Leyden crystal (CLC) protein. The majority of cells (greater than 70%) developing in this system were mature eosinophils, with descending frequency of other cells, including macrophages, mature basophils, eosinophilic myelocytes, and mature neutrophils. Mature eosinophils were characterized by increased numbers of primary granules, small granules, tubulovesicular structures, and decreased secondary granules. These eosinophils showed extensive piecemeal degranulation (PMD) characterized by partially empty and empty secondary granule chambers in the cytoplasm. Small, smooth vesicles were evident within empty granule chambers as well as adjacent to them. Eosinophils formed close associations with phagocytic macrophages that contained both standard-shaped and irregularly shaped CLC within phagolysosomes. Subcellular sites of CLC protein were demonstrated by immunogold in eosinophils and macrophages arising in these cultures. Charcot-Leyden crystal protein was present in the nuclear matrix and extraorganellar cytoplasm of eosinophils. Primary granules and some cytoplasmic vesicles were labeled for CLC protein, but full and empty secondary granules and the extensive network of tubulovesicles were not. Charcot-Leyden crystals were absent from eosinophils, nor were they present in the extracellular space. Charcot-Leyden crystals were absent from eosinophils, nor were they present in the extracellular space. Charcot-Leyden crystals within phagosomes of macrophages were labeled by the immunogold procedure for CLC protein. These results demonstrate that rhIL-5-supplemented, PHA

  20. Maturation of the adolescent brain

    Directory of Open Access Journals (Sweden)

    Arain M

    2013-04-01

    Full Text Available Mariam Arain, Maliha Haque, Lina Johal, Puja Mathur, Wynand Nel, Afsha Rais, Ranbir Sandhu, Sushil Sharma Saint James School of Medicine, Kralendijk, Bonaire, The Netherlands Abstract: Adolescence is the developmental epoch during which children become adults – intellectually, physically, hormonally, and socially. Adolescence is a tumultuous time, full of changes and transformations. The pubertal transition to adulthood involves both gonadal and behavioral maturation. Magnetic resonance imaging studies have discovered that myelinogenesis, required for proper insulation and efficient neurocybernetics, continues from childhood and the brain's region-specific neurocircuitry remains structurally and functionally vulnerable to impulsive sex, food, and sleep habits. The maturation of the adolescent brain is also influenced by heredity, environment, and sex hormones (estrogen, progesterone, and testosterone, which play a crucial role in myelination. Furthermore, glutamatergic neurotransmission predominates, whereas gamma-aminobutyric acid neurotransmission remains under construction, and this might be responsible for immature and impulsive behavior and neurobehavioral excitement during adolescent life. The adolescent population is highly vulnerable to driving under the influence of alcohol and social maladjustments due to an immature limbic system and prefrontal cortex. Synaptic plasticity and the release of neurotransmitters may also be influenced by environmental neurotoxins and drugs of abuse including cigarettes, caffeine, and alcohol during adolescence. Adolescents may become involved with offensive crimes, irresponsible behavior, unprotected sex, juvenile courts, or even prison. According to a report by the Centers for Disease Control and Prevention, the major cause of death among the teenage population is due to injury and violence related to sex and substance abuse. Prenatal neglect, cigarette smoking, and alcohol consumption may also

  1. Maturity model for enterprise interoperability

    Science.gov (United States)

    Guédria, Wided; Naudet, Yannick; Chen, David

    2015-01-01

    Historically, progress occurs when entities communicate, share information and together create something that no one individually could do alone. Moving beyond people to machines and systems, interoperability is becoming a key factor of success in all domains. In particular, interoperability has become a challenge for enterprises, to exploit market opportunities, to meet their own objectives of cooperation or simply to survive in a growing competitive world where the networked enterprise is becoming a standard. Within this context, many research works have been conducted over the past few years and enterprise interoperability has become an important area of research, ensuring the competitiveness and growth of European enterprises. Among others, enterprises have to control their interoperability strategy and enhance their ability to interoperate. This is the purpose of the interoperability assessment. Assessing interoperability maturity allows a company to know its strengths and weaknesses in terms of interoperability with its current and potential partners, and to prioritise actions for improvement. The objective of this paper is to define a maturity model for enterprise interoperability that takes into account existing maturity models while extending the coverage of the interoperability domain. The assessment methodology is also presented. Both are demonstrated with a real case study.

  2. HOW CAN OPPORTUNITY COST BE USED IN DETERMINING THE PROFIT?

    Directory of Open Access Journals (Sweden)

    ȘTELIAC NELA

    2014-08-01

    Full Text Available Opportunity cost is an economic concept which takes on multiple forms of expression. One of these is the foregone profit as a result of the manufacturer’s option to produce goods by quality classes or of its choice of goods with certain values of gross margin and production lead times. This paper is focused on presenting some situations of avoiding opportunity costs within the meaning of foregone profit. To this end we contemplated two situations: i one where manufacturers may opt, or not, to produce branded goods; ii another where a restrictive factor (technical/physical and financial may influence the manufacturer’s decision-making in what type of goods should be manufactured.

  3. Antecedents of Hotel Profitability: Empirical Evidence from Belgrade

    Directory of Open Access Journals (Sweden)

    Miloš Milosavljević

    2016-04-01

    Full Text Available Tourism and hospitality have received an immense attention from scholars, policy holders, decision makers and other important stakeholders in Belgrade, a main tourist destination of Serbia. The aim of this paper is to determine the main drivers of profit margins in the hotel sector in Belgrade. A particular aim is to explore the effects of variables – size, market concentration, and market share and customer satisfaction – on hotel profit margins. The study analyzed the secondary reliable sources. The data were analyzed with correlations and regressions. The results indicate that customer perception is a paramount factor driving the financial performance of hotels. These findings could be useful to scholars and practitioners interested in business performances of Belgrade hotels.

  4. Danwei Profitability and Earnings Inequality in Urban China*

    Science.gov (United States)

    Xie, Yu; Wu, Xiaogang

    2009-01-01

    Prior research has debated the relative importance of such factors as human capital, political capital and region in determining workers’ earnings in reform-era urban China. This article argues that a main agent of social stratification in contemporary China continues to be the danwei, the work unit. Using data from a 1999 survey we conducted in three large Chinese cities, Wuhan, Shanghai and Xi’an, we assess the extent to which workers’ earnings (including regular wages, bonuses and subsidies) depend on the profitability of their danwei. Results show that the financial situation of the danwei is one of the most important determinants of earnings in today’s urban China. Furthermore, the importance of danwei profitability does not vary by city or by employment sector. PMID:20445771

  5. Gender, Worker Representation and the Profitability of Firms in Germany

    Directory of Open Access Journals (Sweden)

    Uwe Jirjahn

    2011-12-01

    Full Text Available Recent research has shown that the unexplained gender wage gap is smaller in establishments where a works council is present. The finding raises the question of whether establishment-level codetermination reduces gender wage discrimination or whether it reduces a wage differential that reflects productivity differences between men and women. This study addresses the question by examining the association between the share of female employees and profitability. Using data from manufacturing establishments, the empirical analysis suggests that there is a positive association between the share of women and profitability in establishments without a works council while there is no association in establishments with a works council. These results support the hypothesis that establishment-level codetermination reduces gender-specific wage discrimination

  6. The Reverse Supply Chain: Configuration, Integration and Profitability

    DEFF Research Database (Denmark)

    Gobbi, Chiara

    2008-01-01

    advantage and generate profit by reconditioning and remarketing used products. Many different flows arise in this context: commercial returns, returns for repair, for refurbishment and for remanufacturing. This study has considered two instances of a value driven reverse chain that recondition electronic......This thesis presents the results of a qualitative investigation that has been conducted in order to enhance knowledge of the reverse supply chain management field. Two aspects of the reverse flow need to be taken into consideration: the importance of introducing mechanisms that promote...... the circuitry of resources in order to protect the environment, and the increasing awareness that if strategically managed, the reverse chain represents an opportunity for profit generation and for improving the competitive position of a firm. In the first case, the main stakeholders are represented...

  7. Evaluating impacts of unexpected earning on precision of profit estimation

    Directory of Open Access Journals (Sweden)

    Hossein Kazemi

    2013-03-01

    Full Text Available Precision in earning report has always been a concern among investors, and when there are some negative adjustments on earning, investor may find it challenging to decide whether they should hold or sell their shares. This paper studies the impact of earning precision and unexpected earning adjustments on firms whose share are listed on Tehran Stock Exchange. The proposed study of this paper considers three hypotheses including whether earning precision has negative relationship with unexpected profit, whether it has a negative with unexpected decline in profit and finally, whether, in prediction on negative news compared with positive news, there is a negative relationship between stronger earnings forecast and precision of earning forecast. The study gathers the necessary data from official news released for some firms whose shares were active over the period 2003-2012. The study uses two regression models and the results of regression analysis have confirmed all hypotheses of this survey.

  8. RESEARCH ON MILK COST, RETURN AND PROFITABILITY IN DAIRY FARMING

    Directory of Open Access Journals (Sweden)

    Agatha POPESCU

    2014-06-01

    Full Text Available The paper aimed to the relationship between milk cost in terms of material cost and labor cost and estimate theinfluence of these costs on returns coming from milk and profitability in 5 small dairy farms from the SouthernRomania. The main economic indicators taken into consideration were: material cost, Xi, (feeding cost, replacingheifer, equipment and shed depreciation, electricity and water cost, fuel and lubricants cost , labour cost, Y, andincome coming from milk, Z. The Cobb-Douglas regression function Z= a xα yβ was used to determine the variationof the studied economic indicators and relationships between them. Taking into account the close relationshipbetween income from marketed milk and material cost and labor cost, it is enough to use it as the only criterion infarm classification. Profitability in dairy farms depends both on cost input and milk output as well as milk marketprice.

  9. Military Veterans’ Experiences in For-Profit Higher Education

    Science.gov (United States)

    2012-05-01

    AND SUBTITLE Military Veterans’ Experiences in For-Profit Higher Education 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6...of accredited public and private higher education institutions— and was funded by the Lumina Foundation for Education. We were asked to study...in higher education institutions from across the nation.5 As shown in Figures 1 and 2, both the focus group and survey samples included a

  10. Spokespersons in media campaigns of non-profit organizations

    OpenAIRE

    Milovanović Dragana

    2014-01-01

    The subject of this research is how spokespersons can be used in campaigns of non-profit organizations, with a goal to increase their visibility and gain public support. Namely, many companies employ celebrities for their media campaigns as protagonists and promoters of brand values. With their appearance and engagement, celebrities transfer part of their image and credibility to the brand, which widens and enriches the field of associations which brands trigger in consumers' conscience. Non-...

  11. Management Control of Public and Not-for-Profit Activities

    OpenAIRE

    Hofstede, G.

    1981-01-01

    Traditional approaches to management control usually fail for public and not-for-profit activities. The type of control applicable to such activities depends on four criteria: are objectives unambiguous, outputs measurable, effects of interventions known, and is the activity repetitive? Depending on where activities stand with regard to these criteria, the control applicable corresponds to one of six different types: routine, expert, trial-and-error, intuitive, judgemental, or political contr...

  12. Winning the oil endgame: innovations for profit, jobs and security

    Energy Technology Data Exchange (ETDEWEB)

    Lovins, Amory B.

    2005-02-15

    Enough about the oil problem. Here's the solution. Over a few decades, starting now, a vibrant US economy (then others) can completely phase out oil. This will save a net $70 billion a year, revitalize key industries and rural America, create a million jobs, and enhance security. Here's the roadmap - independent, peer-reviewed, co-sponsored by the Pentagon - for the transition beyond oil, led by business and profit. (Author)

  13. Reference Tracking and Profit Optimization of a Power Plant

    DEFF Research Database (Denmark)

    Kragelund, Martin Nygaard; Leth, John-Josef; Wisniewski, Rafal

    2010-01-01

    In this paper we discuss two different methods for implementing reference tracking intro a profit optimization problem of a power plant. It is shown that tracking included as a side constraint results in an significant tracking error only when the reference gradient is large. When tracking...... is included in the cost function, as a quadratic term, the reference is tracked with a small accumulated error. Finally, the two methods are compared both in terms of tracking performance and computational burden....

  14. Voluntary disclosure of intangible resources and stock profitability

    OpenAIRE

    Macagnan, Clea Beatriz

    2009-01-01

    The present study analyzes the extent of voluntarily disclosed information about intangible resources, in the annual report of companies from Spain’s capital market, as well as the possibility of there being a correlation between that disclosure and the effective profitability of the stock. In methodological terms, the present research has used semiotic analysis, in order to construe indicators and indexes, and the technique of logistic regression, to analyze the probability of the implicatio...

  15. Profitability analysis of catfish production in Kaduna state, Nigeria ...

    African Journals Online (AJOL)

    The gross farm income was N 1,172,000 per annum while the net farm income was N559, 950 per annum with a return on investment of 0.915 (91.5%). The result indicates that catfish production was profitable in the study are. This also indicates that there is enough employment opportunities in catfish farm in the area, thus ...

  16. An ill-posed problem for the Black-Scholes equation for a profitable forecast of prices of stock options on real market data

    Science.gov (United States)

    Klibanov, Michael V.; Kuzhuget, Andrey V.; Golubnichiy, Kirill V.

    2016-01-01

    A new empirical mathematical model for the Black-Scholes equation is proposed to forecast option prices. This model includes new interval for the price of the underlying stock, new initial and new boundary conditions. Conventional notions of maturity time and strike prices are not used. The Black-Scholes equation is solved as a parabolic equation with the reversed time, which is an ill-posed problem. Thus, a regularization method is used to solve it. To verify the validity of our model, real market data for 368 randomly selected liquid options are used. A new trading strategy is proposed. Our results indicates that our method is profitable on those options. Furthermore, it is shown that the performance of two simple extrapolation-based techniques is much worse. We conjecture that our method might lead to significant profits of those financial insitutions which trade large amounts of options. We caution, however, that further studies are necessary to verify this conjecture.

  17. Internal control over financial reporting and managerial rent extraction: Evidence from the profitability of insider trading

    NARCIS (Netherlands)

    H.A. Skaife (Hollis); D. Veenman (David); D. Wangerin (Daniel)

    2013-01-01

    markdownabstract__Abstract__ This paper examines the association between ineffective internal control over financial reporting and the profitability of insider trading. We predict and find that the profitability of insider trading is significantly greater in firms disclosing material weaknesses

  18. Loss profit estimation using association rule mining with clustering

    Directory of Open Access Journals (Sweden)

    Mandeep Mittal

    2015-02-01

    Full Text Available Data mining is the technique to find hidden patterns from a very large volume of historical data. Association rule is a type of data mining that correlates one set of items or events with another set of items or events. Another data mining strategy is clustering technique. This technique is used to create partitions so that all members of each set are similar according to a specified set of metrics. Both the association rule mining and clustering helps in more effective individual and group decision making for optimal inventory control. Owing to the above facts, association rules are mined from each cluster to find frequent items and then loss profit is calculated for each frequent item. Initially, the clustering algorithm is used to partition the transactional database into different clusters. Apriori, a classic data mining algorithm is utilized for mining association rules from each cluster to find frequent items. Later the loss profit is calculated for each frequent item. The obtained loss profit is used to rank frequent items in each cluster. Thus, the ranking of frequent items in each cluster using the proposed approach greatly facilitate optimal inventory control. An example is illustrated to validate the results.

  19. Spokespersons in media campaigns of non-profit organizations

    Directory of Open Access Journals (Sweden)

    Milovanović Dragana

    2014-01-01

    Full Text Available The subject of this research is how spokespersons can be used in campaigns of non-profit organizations, with a goal to increase their visibility and gain public support. Namely, many companies employ celebrities for their media campaigns as protagonists and promoters of brand values. With their appearance and engagement, celebrities transfer part of their image and credibility to the brand, which widens and enriches the field of associations which brands trigger in consumers' conscience. Non-profit organizations could get similar benefits out of these campaigns. In a society where there is a certain level of fascination with celebrities, i.e. celebrity culture, their influence can be used not only to attract attention to the goods, but also to ideas. The goal of the paper is to show how spokespersons can influence behavior and attitudes of the public by participating in media campaigns, and also the important aspects of choosing a spokesperson. The paper is supposed to be a starting point for practitioners,so they can design creative ideas based on this technique on the non-profit organizations market, especially in Serbia.

  20. SISTEM PROFIT PERBANKAN BUMN INDONESIA (STUDI KASUS : BANK MANDIRI 2006

    Directory of Open Access Journals (Sweden)

    Erma Suryani

    2011-07-01

    Full Text Available Normal 0 false false false IN X-NONE X-NONE MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0cm 5.4pt 0cm 5.4pt; mso-para-margin:0cm; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;} Perbankan merupakan salah satu komponen yang sangat penting dalam perekonomian di Indonesia. Dalam suatu organisasi perbankan, suatu transaksi yang dilakukan dengan nasabah akan berpengaruh terhadap aliran dana pada bank (cash flow, sehingga dapat diketahui total profit yang telah diperoleh. Untuk mengetahui profit perbankan dari studi kasus yang diangkat, maka digunakan simulasi menggunakan vensim atau simulasi dengan sistem dinamik dengan skenariosasi parameter dan struktur. Dengan skenariosasi yang diusulkan, dapat dihasilkan profit yang lebih efektif dibandingkan dengan sistem yang digunakan sekarang ini.

  1. Health systems: changes in hospital efficiency and profitability.

    Science.gov (United States)

    Büchner, Vera Antonia; Hinz, Vera; Schreyögg, Jonas

    2016-06-01

    This study investigates potential changes in hospital performance after health system entry, while differentiating between hospital technical and cost efficiency and hospital profitability. In the first stage we obtained (bootstrapped) data envelopment analysis (DEA) efficiency scores. Then, genetic matching is used as a novel matching procedure in this context along with a difference-in-difference approach within a panel regression framework. With the genetic matching procedure, independent and health system hospitals are matched along a number of environmental and organizational characteristics. The results show that health system entry increases hospital technical and cost efficiency by between 0.6 and 3.4 % in four alternative post-entry periods, indicating that health system entry has not a transitory but rather a permanent effect on hospital efficiency. Regarding hospital profitability, the results reveal an increase in hospital profitability only 1 year after health system entry, and the estimations suggest that this effect is a transitional phenomenon. Overall, health system entry may serve as an appropriate management instrument for decision makers to increase hospital performance.

  2. Invited review: selection on net merit to improve lifetime profit.

    Science.gov (United States)

    VanRaden, P M

    2004-10-01

    Genetic selection has made dairy cows more profit-able producers of milk. Genetic evaluations began with 2 traits measured on a few cows but now include many traits measured on millions of cows. Selection indexes from USDA included yield traits beginning in 1971, productive life and somatic cell score beginning in 1994, conformation traits in 2000, and cow fertility and calving ease in 2003. This latest revision of net merit should result in 2% more progress, worth 5 million dollars/yr nationally, with improved cow health and fitness, but slightly less progress for yield. Fertility and longevity evaluations have similar reliability because cows can have several fertility records, each with lower heritability, compared with one longevity record with higher heritability. Lifetime profit can be estimated more accurately if less heritable traits are evaluated and included instead of ignored. Milk volume has a positive value for fluid use, but a negative value for cheese production. Thus, multiple selection indexes are needed for different markets and production systems. Breeding programs should estimate future rather than current costs and prices. Many other nations have derived selection indexes similar to US net merit.

  3. 7 CFR 51.1904 - Maturity classification.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Maturity classification. 51.1904 Section 51.1904... STANDARDS) United States Consumer Standards for Fresh Tomatoes Size and Maturity Classification § 51.1904 Maturity classification. Tomatoes which are characteristically red when ripe, but are not overripe or soft...

  4. Micropropagation of juvenile and mature american beech

    Science.gov (United States)

    Melanie J. Barker; Paula M. Pijut; Michael E. Ostry; David R. Houston

    1997-01-01

    The purpose of this study was to micropropagate juvenile and mature American beech (Fagus grandifolia Ehrh.) resistant to beech bark disease. Shoot tips (from juvenile seedlings and root sprouts of mature trees) and buds from branches of mature trees, were cultured and multiplied on aspen culture medium supplemented with 0.89 ?M 6-benzyladenine, 0.27 ?M a-...

  5. Screen Wars, Star Wars, and Sequels: Nonparametric Reanalysis of Movie Profitability

    OpenAIRE

    Walls, W. D.

    2012-01-01

    In this paper we use nonparametric statistical tools to quantify motion-picture profit. We quantify the unconditional distribution of profit, the distribution of profit conditional on stars and sequels, and we also model the conditional expectation of movie profits using a non- parametric data-driven regression model. The flexibility of the non-parametric approach accommodates the full range of possible relationships among the variables without prior specification of a functional form, thereb...

  6. Valuing goodwill: not-for-profits prepare for annual impairment testing.

    Science.gov (United States)

    Heuer, Christian; Travers, Mary Ann K

    2011-02-01

    Accounting standards for valuing goodwill and intangible assets are becoming more rigorous for not-for-profit organizations: Not-for-profit healthcare organizations need to test for goodwill impairment at least annually. Impairment testing is a two-stage process: initial analysis to determine whether impairment exists and subsequent calculation of the magnitude of impairment. Certain "triggering" events compel all organizations--whether for-profit or not-for-profit--to perform an impairment test for goodwill or intangible assets.

  7. Does Firm Size Affect the Firm Profitability? Empirical Evidence from Romania

    OpenAIRE

    Georgeta VINTILA; Florinita DUCA

    2013-01-01

    This study advances the understanding of the relationship between firm size and profitability, motivated by the question whether larger firms are more profitable. The nature of the relationship between firm size and firm profitability is examined by on data for 100 firms listed in 2010 at the Bucharest Stock Exchange. The results revealed that firm size has a significant negative influence on firm profitability. Additionally, results showed that leverage is statistically significantly, while ...

  8. Alternative Pathways to Legitimacy: Promotional Practices in the Ontario For-Profit College Sector

    Science.gov (United States)

    Pizarro Milian, Roger; Quirke, Linda

    2017-01-01

    This study empirically examines how for-profit career colleges in Ontario, Canada market themselves to prospective students. It uses a mixed-methods approach to review the content of 489 online promotional profiles representing 375 unique for-profit colleges. It finds that for-profit colleges adopt several distinct marketing strategies, including…

  9. 10 CFR 603.615 - Financial management standards for-profit firms.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Financial management standards for-profit firms. 603.615... § 603.615 Financial management standards for-profit firms. (a) To avoid causing needless changes in participants' financial management systems, an expenditure-based TIA will make for-profit participants that...

  10. 26 CFR 1.401-1 - Qualified pension, profit-sharing, and stock bonus plans.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 5 2010-04-01 2010-04-01 false Qualified pension, profit-sharing, and stock... TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Pension, Profit-Sharing, Stock Bonus Plans, Etc. § 1.401-1 Qualified pension, profit-sharing, and stock bonus plans. (a) Introduction. (1) Sections 401...

  11. 10 CFR 603.650 - Designation of auditor for for-profit participants.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Designation of auditor for for-profit participants. 603... Financial Matters § 603.650 Designation of auditor for for-profit participants. The auditor identified in an... circumstances, as follows: (a) The Federal cognizant agency or an IPA will be the auditor for a for-profit...

  12. Estimating profit shifting in South Africa using firm-level tax returns

    DEFF Research Database (Denmark)

    Wier, Ludvig

    2016-01-01

    Using the universe of South African corporate tax returns for 2009–14, we estimate profit- and debt-shifting responses in South Africa. We find evidence that South African subsidiaries engage in profit shifting and that profit-shifting responses to tax incentives across all channels...

  13. Deterministic Price Setting Rules to Guarantee Profitability of Unbundling in the Airline Industry

    NARCIS (Netherlands)

    Van Diepen, G.; Curran, R.

    2011-01-01

    Unbundling the traditional airfare is one of the airline industry’s practices to generate ancillary revenue in its struggle for profitability. However, unbundling might just as well negatively affect profit. In this paper deterministic price setting rules are established to guarantee profitability

  14. 26 CFR 1.537-2 - Grounds for accumulation of earnings and profits.

    Science.gov (United States)

    2010-04-01

    ... indicate that the earnings and profits of a corporation are being accumulated beyond the reasonable needs... 26 Internal Revenue 7 2010-04-01 2010-04-01 true Grounds for accumulation of earnings and profits... Shareholders § 1.537-2 Grounds for accumulation of earnings and profits. (a) In general. Whether a particular...

  15. Energy productivity, fertilization rate and profitability of wheat production after various predecessors II.Profitability of wheat production

    Directory of Open Access Journals (Sweden)

    Z. Uhr

    2016-03-01

    Full Text Available Abstract. In the course of our study on the adaptation of modern genotypes common winter wheat (Triticum aestivum to the requirements of sustainable agriculture data were received concerning the influence of the predecessor and nitrogen fertilizer rate on energy efficiency and recyclable nitrogen fertilization and profitability of productivity.We share these data with the scientific community, as they are up-to-date and informative in both theoretical and practical aspects. The analyses are based on data from field experiments fertilizer derived after predecessor cereals – regular crop of sorghum, millet, maize and legumes after predecessor - separate sowing of chickpeas. Energy efficiency of nitrogen fertilization was calculated as the ratio between the energy supplied in the additional grain yield and energy input in the form of fertilizers. Refundable efficiency of nitrogen fertilization is the additional amount of nitrogen accumulated in the grain, with respect to the applied nitrogen fertilization. Economic profitability of production is evaluated by coefficient R = P/Ra (ratio of benefits/costs. The results show that energy efficiency and recyclable nitrogen fertilization are on average five times higher after cereal than after legumes predecessor, and decreased with increasing the fertilizer rate, the decrease was statistically significant only for the first item (exponent. Profitability ratio of production after the introduction of legumes predecessor in crop rotation increases by an average of 42% and retains maximum values of fertilization levels 0.06, 0.12 and 0.18 t/ha nitrogen. Profitability of wheat production using pre-legumes crop is not determined by the parameters nitrogen fertilizer rate and energy efficiency of nitrogen fertilization and refundable efficiency of nitrogen fertilization.

  16. Laws of motion in the for-profit health industry: a theory and three examples.

    Science.gov (United States)

    Stevenson, G

    1978-01-01

    The dynamics generated in the for-profit health industry by the drive for accumulation combine with the life cycle of a product to produce, within a given political framework, tendencies toward certain types of industry structure. The evolution of this structure is characterized by increased concentration of economic activity in diversified multinational corporations which combine health and non-health products. Three industries representing different stages of product and market development are analyzed in this article. The pharmacological industry is a mature industry dominated by large diversified multinational corporations which grow mainly through expansion abroad and diversification. The medical and dental instruments and supplies industry is newer, smaller, and faster growing. Its growth potential is attracting many companies an; increasing competition. The newest industry, investor-owned hospitals and hospital chains, is characterized by rapidly growing but still relatively small companies. The appendix, included to illustrate certain social, economic, and political issues, focuses on Medtronics, a highly scientific, fast-growing firm which produces electronic pacemakers.

  17. Academic Achievement of High School Students in Relation to Their Anxiety, Emotional Maturity and Social Maturity

    Science.gov (United States)

    Puar, Surjit Singh

    2013-01-01

    The present study has been designed to investigate the non-cognitive variables like anxiety, emotional maturity and social maturity and their relationship with academic achievement and also to see the locale-wise differences on the basis of their anxiety, emotional maturity and social maturity. The study was conducted over a sample of 400 (200…

  18. Operating Profitability of For-Profit and Not-for-Profit Florida Community Hospitals During Medicare Policy Changes, 2000 to 2010

    Directory of Open Access Journals (Sweden)

    Barbara Langland-Orban PhD

    2015-08-01

    Full Text Available Medicare Advantage was implemented in 2004 and the Recovery Audit Contractor (RAC program was implemented in Florida during 2005. Both increase surveillance of medical necessity and deny payments for improper admissions. The purpose of the present study was to determine their potential impact on for-profit (FP and not-for-profit (NFP hospital operating margins in Florida. FP hospitals were expected to be more adversely affected as admissions growth has been one strategy to improve stock performance, which is not a consideration at NFPs. This study analyzed Florida community hospitals from 2000 through 2010, assessing changes in pre-tax operating margin (PTOM. Florida Agency for Health Care Administration data were analyzed for 104 community hospitals (62 FPs and 42 NFPs. Academic, public, and small hospitals were excluded. A mixed-effects model was used to assess the association of RAC implementation, organizational and payer type variables, and ownership interaction effects on PTOM. FP hospitals began the period with a higher average PTOM, but converged with NFPs during the study period. The average Medicare Advantage effect was not significant for either ownership type. The magnitude of the RAC variable was significantly negative for average PTOM at FPs (−4.68 and positive at NFPs (0.08, meaning RAC was associated with decreasing PTOM at FP hospitals only. RAC complements other Medicare surveillance systems that detect medically unnecessary admissions, coding errors, fraud, and abuse. Since its implementation in Florida, average FP and NFP operating margins have been similar, such that the higher margins reported for FP hospitals in the 1990s are no longer evident.

  19. Operating Profitability of For-Profit and Not-for-Profit Florida Community Hospitals During Medicare Policy Changes, 2000 to 2010.

    Science.gov (United States)

    Langland-Orban, Barbara; Large, John T; Sear, Alan M; Zhang, Hanze; Zhang, Nanhua

    2015-01-01

    Medicare Advantage was implemented in 2004 and the Recovery Audit Contractor (RAC) program was implemented in Florida during 2005. Both increase surveillance of medical necessity and deny payments for improper admissions. The purpose of the present study was to determine their potential impact on for-profit (FP) and not-for-profit (NFP) hospital operating margins in Florida. FP hospitals were expected to be more adversely affected as admissions growth has been one strategy to improve stock performance, which is not a consideration at NFPs. This study analyzed Florida community hospitals from 2000 through 2010, assessing changes in pre-tax operating margin (PTOM). Florida Agency for Health Care Administration data were analyzed for 104 community hospitals (62 FPs and 42 NFPs). Academic, public, and small hospitals were excluded. A mixed-effects model was used to assess the association of RAC implementation, organizational and payer type variables, and ownership interaction effects on PTOM. FP hospitals began the period with a higher average PTOM, but converged with NFPs during the study period. The average Medicare Advantage effect was not significant for either ownership type. The magnitude of the RAC variable was significantly negative for average PTOM at FPs (-4.68) and positive at NFPs (0.08), meaning RAC was associated with decreasing PTOM at FP hospitals only. RAC complements other Medicare surveillance systems that detect medically unnecessary admissions, coding errors, fraud, and abuse. Since its implementation in Florida, average FP and NFP operating margins have been similar, such that the higher margins reported for FP hospitals in the 1990s are no longer evident. © The Author(s) 2015.

  20. How is Size Related to Profitability? Post-Consolidation Evidence from Selected Banks in Nigeria

    Directory of Open Access Journals (Sweden)

    Funso T. Kolapo

    2016-10-01

    Full Text Available It is theoretically believed that increase in firm size would result to increase in firm profitability. Therefore, this study examines the relationship between size and profitability of six banks in Nigeria after the 2005 consolidation exercise. The measure of profitability is return on assets. Employing the static panel data regression method, the study found that size has an insignificant negative relationship with bank profitability. This study concludes that the 2005 consolidation exercise did not enhance the profitability of the selected banks.

  1. Strategies and techniques of communication and public relations applied to non-profit sector

    Directory of Open Access Journals (Sweden)

    Ioana – Julieta Josan

    2010-05-01

    Full Text Available The aim of this paper is to summarize the strategies and techniques of communication and public relations applied to non-profit sector.The approach of the paper is to identify the most appropriate strategies and techniques that non-profit sector can use to accomplish its objectives, to highlight specific differences between the strategies and techniques of the profit and non-profit sectors and to identify potential communication and public relations actions in order to increase visibility among target audience, create brand awareness and to change into positive brand sentiment the target perception about the non-profit sector.

  2. The importance of working capital management for hospital profitability: evidence from bond-issuing, not-for-profit U.S. hospitals.

    Science.gov (United States)

    Rauscher, Simone; Wheeler, John R C

    2012-01-01

    Increased financial pressures on hospitals have elevated the importance of working capital management, that is, the management of current assets and current liabilities, for hospitals' profitability. Efficient working capital management allows hospitals to reduce their holdings of current assets, such as inventory and accounts receivable, which earn no interest income and require financing with short-term debt. The resulting cash inflows can be reinvested in interest-bearing financial instruments or used to reduce short-term borrowing, thus improving the profitability of the organization. This study examines the relationship between hospitals' profitability and their performance at managing two components of working capital: accounts receivable, measured in terms of hospitals' average collection periods, and accounts payable, measured in terms of hospitals' average payment periods. Panel data derived from audited financial statements for 1,397 bond-issuing, not-for-profit U.S. hospitals for 2000-2007 were analyzed using hospital-level fixed-effects regression analysis. The results show a negative relationship between hospitals' average collection period and profitability. That is, hospitals that collected on their patient revenue faster reported higher profit margins than did hospitals that have larger balances of accounts receivable outstanding. We also found a negative relationship between hospitals' average payment period and their profitability. Hospital managers did not appear to delay paying their vendors. Rather, the findings indicated that more profitable hospitals paid their suppliers faster, possibly to avoid high effective interest rates on outstanding accounts payable, whereas less profitable hospitals waited longer to pay their bills. The findings of this study suggest that working capital management indeed matters for hospitals' profitability. Efforts aimed at reducing large balances in both accounts receivable and accounts payable may frequently be

  3. Profit efficiency of shariah banks in Indonesia and the determining factors: Using Stochastic Frontier Analysis Method

    Directory of Open Access Journals (Sweden)

    Sri Wahyuni

    2016-11-01

    Full Text Available This study aims to measure the efficiency of profit and examine the factors that affect the efficiency of shariah banks profit in Indonesia such as the size of banks, risk financing, and capital adequacy. This study used the Shariah banks in Indonesia, during the period of 2010-2014. These shariah banks were selected as the sample Commercial shariah banks and Shariah Business Units. This study uses three stages of research. First, it measures the efficiency of profit using a parametric approach that is Stochastic Frontier Approach (SFA. Secondly, its uses regression profit efficiency scores with various determinants of profit efficiency. The third phase is testing the efficiency score during the global crisis (2008-2009 and after the global crisis period (2010-2014. It shows that in overall there occurred profit efficiency in the shariah banks in Indonesia as it was indicated by the score of profit efficiency that is less than one. The inefficiency occurred in both Shariah banks and shariah business units. Bank size has a positive impact on profit efficiency. The bigger the bank, the better profit efficiency is. It can be implied that this research provides the managers the clues that shariah banks should improve their profit efficiency management. For Bank Indonesia, they can use this evidence to design policies that can encourage profit efficiency in shariah banks.

  4. Profitability and sustainability of small - medium scale palm biodiesel plant

    Science.gov (United States)

    Solikhah, Maharani Dewi; Kismanto, Agus; Raksodewanto, Agus; Peryoga, Yoga

    2017-06-01

    The mandatory of biodiesel application at 20% blending (B20) has been started since January 2016. It creates huge market for biodiesel industry. To build large-scale biodiesel plant (> 100,000 tons/year) is most favorable for biodiesel producers since it can give lower production cost. This cost becomes a challenge for small - medium scale biodiesel plants. However, current biodiesel plants in Indonesia are located mainly in Java and Sumatra, which then distribute biodiesel around Indonesia so that there is an additional cost for transportation from area to area. This factor becomes an opportunity for the small - medium scale biodiesel plants to compete with the large one. This paper discusses the profitability of small - medium scale biodiesel plants conducted on a capacity of 50 tons/day using CPO and its derivatives. The study was conducted by performing economic analysis between scenarios of biodiesel plant that using raw material of stearin, PFAD, and multi feedstock. Comparison on the feasibility of scenarios was also conducted on the effect of transportation cost and selling price. The economic assessment shows that profitability is highly affected by raw material price so that it is important to secure the source of raw materials and consider a multi-feedstock type for small - medium scale biodiesel plants to become a sustainable plant. It was concluded that the small - medium scale biodiesel plants will be profitable and sustainable if they are connected to palm oil mill, have a captive market, and are located minimally 200 km from other biodiesel plants. The use of multi feedstock could increase IRR from 18.68 % to 56.52 %.

  5. profit: a new alternative for emission-line profile fitting

    Science.gov (United States)

    Riffel, Rogemar A.

    2010-06-01

    I briefly describe a simple routine for emission-line profile fitting by Gaussian curves or Gauss-Hermite series. The profit (line- profile fitting) routine represent a new alternative for use in fits data cubes, as the ones from Integral Field Spectroscopy or Fabry-Pérot Interferometry, and may be useful to better study the emission-line flux distributions and gas kinematics in distinct astrophysical objects, such as the central regions of galaxies and star forming regions. The profit routine is written in IDL language and is available at http://www.ufsm.br/rogemar/software.html . The profit routine was used to fit the [Fe ii] λ=1.257 μm emission-line profiles for about 1800 spectra of the inner 350 pc of the Seyfert galaxy Mrk 1066 obtained with Gemini NIFS and shows that the line profiles are better reproduced by Gauss-Hermite series than by the commonly used Gaussian curves. The two-dimensional map of the h 3 Gauss-Hermite moment shows its highest absolute values to be in regions close to the edge of the radio structure. These high values may be originating with an biconical outflowing gas associated with the radio jet—previously observed in the optical [O iii] emission. The analysis of this kinematic component indicates that the radio jet leaves the center of the galaxy with the north-west side slightly oriented towards us and the south-east side away from us, being partially hidden by the disc of the galaxy.

  6. The effect of independent auditor's report on profit distribution policy: Evidence from Tehran Stock Exchange

    Directory of Open Access Journals (Sweden)

    Parviz Piri

    2014-07-01

    Full Text Available Profit distribution is one of the most debatable subjects in financial field. Opposite theoretical models that sometimes, do not have a strong empirical support look for the explanation of corporate dividend policy. In this paper, the relationship between profit sharing policy and auditor`s and managers’ expected profit is studied. The study gathers the necessary information of 99 firms listed on Tehran Stock Exchange over the period 2002-2011. The implementation of regression analysis shows that there was more explanatory power of auditors’ expected profit than managers’ expected profit in dividends. The results also show that there was no meaningful difference between auditors` expected profit and managers` expected profit.

  7. Comparative analysis of profit between three dissimilar repairable redundant systems using supporting external device for operation

    Science.gov (United States)

    Yusuf, Ibrahim

    2014-07-01

    The importance in promoting, sustaining industries, manufacturing systems and economy through reliability measurement has become an area of interest. The profit of a system may be enhanced using highly reliable structural design of the system or subsystem of higher reliability. On improving the reliability and availability of a system, the production and associated profit will also increase. Reliability, availability and profit are some of the most important factors in any successful industry and manufacturing settings. In this paper, we compare three different repairable redundant systems using an external supporting device for operation based on the profit. Explicit expressions for the busy period of repairmen, steady-state availability and profit function are derived using linear first-order differential equations. Furthermore, we compare the profit for the three systems and find that system I is more profitable than systems II and III.

  8. Can worksite nutritional interventions improve productivity and firm profitability?

    DEFF Research Database (Denmark)

    Jensen, Jørgen Dejgård

    2011-01-01

    Aims: This paper investigates whether and how worksite nutrition policies can improve employee productivity. Methods: The questions are pursued through a literature review, including a systematic search of literature – combined with literature identified from backward references – on randomized......’ nutritional knowledge, food intake and health and on the firm’s profitability, mainly in terms of reduced absenteeism and presenteeism. Conclusions: Well-targeted and efficiently implemented diet-related worksite health promotion interventions may improve labour productivity by 1%–2%. On larger worksites...

  9. The role and importance of Non-Profit Organizations

    Directory of Open Access Journals (Sweden)

    Nicoleta Ciucescu

    2009-12-01

    Full Text Available In a complex and challenging background of the whole country, and the NGO sector also, the non-profit organizations are established with the aim of providing public services to communities where they operate, making them as an intermediary between citizens and authorities. In any democratic society these organizations are meant to serve different types of needs and interests of the community, from both a strategic perspective and ethics, that those which are not covered by other categories of institutions and organizations, mean time providing a framework for civic participation, where citizens may participate to the public life.

  10. Metrology-based control and profitability in the semiconductor industry

    Science.gov (United States)

    Weber, Charles

    2001-06-01

    This paper summarizes three studies of the semiconductor industry conducted at SEMATECH and MIT's Sloan School of Management. In conjunction they lead to the conclusion that rapid problem solving is an essential component of profitability in the semiconductor industry, and that metrology-based control is instrumental to rapid problem solving. The studies also identify the need for defect attribution. Once a source of a defect has been identified, the appropriate resources--human and technological--need to be brought into the physically optimal location for corrective action. The Internet is likely to enable effective defect attribution by inducing collaboration between different companies.

  11. PARTICULARITIES REGARDING THE CALCULATION AND PROFITABILITY ANALYSIS OF FARMS

    Directory of Open Access Journals (Sweden)

    Daniela SIMTION

    2015-04-01

    Full Text Available In contrast to the industry, in the agricultural production process, specific factors intervene, which determine peculiarities in the use of labor, means of production and work items. The specific factors acting in the agricultural production process: land, plants, animals, soil and climate conditions, give special features regarding the development strategy, but also regarding the production processes with the two sides: technological and economical, causing certain features with effects on the methodology of economic analysis. These features of farm profitability analysis were briefly presented in this study.

  12. Curve fitting for RHB Islamic Bank annual net profit

    Science.gov (United States)

    Nadarajan, Dineswary; Noor, Noor Fadiya Mohd

    2015-05-01

    The RHB Islamic Bank net profit data are obtained from 2004 to 2012. Curve fitting is done by assuming the data are exact or experimental due to smoothing process. Higher order Lagrange polynomial and cubic spline with curve fitting procedure are constructed using Maple software. Normality test is performed to check the data adequacy. Regression analysis with curve estimation is conducted in SPSS environment. All the eleven models are found to be acceptable at 10% significant level of ANOVA. Residual error and absolute relative true error are calculated and compared. The optimal model based on the minimum average error is proposed.

  13. Roy Greenslade, Press Gang - How Newspapers Make Profits From Propaganda

    Directory of Open Access Journals (Sweden)

    Gilbert Millat

    2005-01-01

    Full Text Available Avec son titre Press Gang en rouge sur fond noir, la volumineuse étude de Roy Greenslade, au sous-titre accrocheur How Newspapers Make Profits From Propaganda, se présente davantage sous les dehors d’un roman policier que d’un ouvrage savant. Au terme d’une longue carrière de journaliste, l’auteur, ancien rédacteur en chef du Daily Mirror et qui a collaboré à neuf journaux nationaux, est devenu Professor of Journalism à la City University de Londres. Grâce à sa connaissance encyclopédique du ...

  14. Retrovirus maturation-an extraordinary structural transformation.

    Science.gov (United States)

    Mattei, Simone; Schur, Florian Km; Briggs, John Ag

    2016-06-01

    Retroviruses such as HIV-1 assemble and bud from infected cells in an immature, non-infectious form. Subsequently, a series of proteolytic cleavages catalysed by the viral protease leads to a spectacular structural rearrangement of the viral particle into a mature form that is competent to fuse with and infect a new cell. Maturation involves changes in the structures of protein domains, in the interactions between protein domains, and in the architecture of the viral components that are assembled by the proteins. Tight control of proteolytic cleavages at different sites is required for successful maturation, and the process is a major target of antiretroviral drugs. Here we will describe what is known about the structures of immature and mature retrovirus particles, and about the maturation process by which one transitions into the other. Despite a wealth of available data, fundamental questions about retroviral maturation remain unanswered. Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.

  15. Increasing the Company’s Profitability Through Logistics Management

    Directory of Open Access Journals (Sweden)

    Mihail Romulus Rădulescu

    2012-05-01

    Full Text Available The objective of the paper “Increasing the company’s profitability through logistics management”is to present the significance of organizing an efficient logistics activity and the challenges that the companiesare facing in order to obtain full advantage from using logistics as a competitive tool. The companies’dependence from the strategic decisions belonging to the supply chain stands as a reason for the ever growinginterest towards Supply Chain Management and towards applying innovative processes that will offer anadvantage when faced with increasingly tougher competition from domestic or foreign companies. Thecompany’s characteristics can be subject to deep changes through decisions pertaining to the supply chain;these decisions are vital to the company’s productivity and competitiveness. If the logistics’ role in increasingthe company’s profitability is acknowledged, then implementing complex technologies and investing multiplefactors into improving logistical performance is fully justified. Customer orientation and focusing on keyactivities, which need to be performed daily in order to meet customer demand are absolutely necessary in asystem which implies fast reaction to market changes. The managerial way of thinking has changedsignificantly in the last years, because of the highly global competitiveness, the pressure to reduce costs,focusing on the company’s central competence. The principle of functioning is an aggregate system approachfor the entire flow of information, materials and services beginning with supply of raw material, processesand movements inside the factories and warehouses, until the products reach the final customer.

  16. How to plan a flood for efficiency and profit

    Energy Technology Data Exchange (ETDEWEB)

    Brown, C.A.; Bass, W.A. Jr.

    1972-10-01

    There are proven, planned steps that will assist an operator achieve maximum profit from a secondary waterflood of a previously unprofitable lease. The operator has a major decision to make: plug and abandon, or attempt some form of secondary recovery. The present need for additional oil and the inherent risk of exploration drilling are incentives for the small operator to review these marginal leases for a possible secondary project. The operations should follow definite planning steps to insure the financial success of his project, as follows: (1) conduct a preliminary check to determine if there is a chance to waterflood the producing reservoir; (2) contact all field operators to determine their interest in a secondary recovery project; (3) prepare an engineering feasibility study; (4) unitize operating interest and royalty interest; (5) develop the project for waterflooding using detailed cost analysis for equipment, water supply and water system, well workovers, and power sources; and (6) maintain accurate performance and cost records on water injection, handling of water, including power and chemicals, equipment, and the reservoir. Secondary waterflooding today requires complete and accurate performance records, if they are to be operated efficiently and profitably. An example is given.

  17. Profitability of irradiation plants; Rentabilidad de plantas de irradiacion

    Energy Technology Data Exchange (ETDEWEB)

    Bustos R, M.E.; Gonzalez F, C.; Liceaga C, G.; Ortiz A, G. [Instituto Nacional de Investigaciones Nucleares, Apdo. Postal 18-1027, Col. Escandon, 11801 Mexico D.F. (Mexico)

    1997-12-31

    In any industrial process it is seek an attractive profit from the contractor and the social points of view. The use of the irradiation technology in foods allows keep their hygienically, which aid to food supply without risks for health, an increment of new markets and a losses reduction. In other products -cosmetics or disposable for medical use- which are sterilized by irradiation, this process allows their secure use by the consumers. The investment cost of an irradiation plant depends mainly of the plant size and the radioactive material reload that principally is Cobalt 60, these two parameters are in function of the type of products for irradiation and the selected doses. In this work it is presented the economic calculus and the financial costs for different products and capacities of plants. In general terms is determined an adequate utility that indicates that this process is profitable. According to the economic and commercial conditions in the country were considered two types of credits for the financing of this projects. One utilizing International credit resources and other with national sources. (Author)

  18. Sustainability, productivity, and profitability of agroecosystems under variable rainfall

    Science.gov (United States)

    Vico, G.; Porporato, A. M.

    2010-12-01

    Agriculture is by far the most important user of freshwater and the role of irrigation is projected to increase in face of climate change and increased food requirements. Hence, it is becoming imperative to sustainably manage the available water resources, while simultaneously meeting yield and profitability targets. Simple, widely applicable models of irrigation provide the key irrigation quantities (volumes, frequencies, etc.) for different irrigation schemes as a function of the main soil, crop, and climatic features, including rainfall unpredictability and are necessary for short- and long-term water resource management. We consider often-employed irrigation methods (e.g., surface and sprinkler irrigation systems, as well as modern micro-irrigation techniques) and describe them under a unified conceptual and theoretical framework that includes rainfed agriculture and stress-avoidance irrigation as extreme cases. Mostly analytical solutions for the stochastic steady state of soil moisture probability density function with random rainfall timing and amount are employed to compute water requirements, yields, and net economic gain as a function of climate, crop, and soil parameters. These results provide the necessary starting point to quantify the risks that a certain target yield or profit is not met for given irrigation strategies, with clear implications on food security

  19. Prevention before profits: a levy on food and alcohol advertising.

    Science.gov (United States)

    Harper, Todd A; Mooney, Gavin

    2010-04-05

    The recent interest in health promotion and disease prevention has drawn attention to the role of the alcohol and junk-food industries. Companies supplying, producing, advertising or selling alcohol or junk food (ie, foods with a high content of fat, sugar or salt) do so to generate profits. Even companies marketing "low-carbohydrate" beers, "mild" cigarettes, or "high-fibre" sugary cereals are not primarily concerned about population health, more so increased sales and profits. In a competitive market, it is assumed that consumers make fully informed choices about costs and benefits before purchasing. However, consumers are not being fully informed of the implications of their junk-food and alcohol choices, as advertising of these products carries little information on the health consequences of consumption. We propose that there should be a levy on advertising expenditure for junk food and alcoholic beverages to provide an incentive for industry to promote healthier products. Proceeds of the levy could be used to provide consumers with more complete and balanced information on the healthy and harmful impacts of food and alcohol choices. Our proposal addresses two of the greatest challenges facing Australia's preventable disease epidemic - the imbalance between the promotion of healthier and unhealthy products, and securing funds to empower consumer choice.

  20. Profitability of Two Shepherding Systems for Production of Ovine Meat

    Directory of Open Access Journals (Sweden)

    Daniel Fernando González Mendoza

    2014-11-01

    Full Text Available In Güican (Boyacá, sheep production occupies one of the main items on the economy of the region, despite of being one of the largest, most relevant andimportant business, studies have not been developed to establish that is an efficient and sustainable business. For this reason a research was carried out in theFinca Ronces Güican, where two systems of grazing were temporarily implemented, an extensive traditional and rotational grazing. Forage present in thegrazing area were: Molasses grass (Melinis minutiflora, Kidney weed (Dichondra repens and Dutch clover (Trifolium repens L; 24 creoles sheep were used persystem, selected according to age and sex, achieving uniformity in both groups used. The study was developed for 4 months in order to assess weight gain andprofitability, by assessing and weighing the animals every 15 days. These data were recorded and once the trial period finished, comparisons were made todetermine the effectiveness of each system. It was found that there is a significant difference between the two systems in terms of weight gain. In this way, in theconventional extensive system, sheep had a mean weight gain of 35.47 g / day, while in the rotational system the average profit was 124.24 g / day, so it wasconcluded that the rotational system is more profitable, since it has a return on capital of 8% over the traditional extensive system.

  1. Optimum profit model considering production, quality and sale problem

    Science.gov (United States)

    Chen, Chung-Ho; Lu, Chih-Lun

    2011-12-01

    Chen and Liu ['Procurement Strategies in the Presence of the Spot Market-an Analytical Framework', Production Planning and Control, 18, 297-309] presented the optimum profit model between the producers and the purchasers for the supply chain system with a pure procurement policy. However, their model with a simple manufacturing cost did not consider the used cost of the customer. In this study, the modified Chen and Liu's model will be addressed for determining the optimum product and process parameters. The authors propose a modified Chen and Liu's model under the two-stage screening procedure. The surrogate variable having a high correlation with the measurable quality characteristic will be directly measured in the first stage. The measurable quality characteristic will be directly measured in the second stage when the product decision cannot be determined in the first stage. The used cost of the customer will be measured by adopting Taguchi's quadratic quality loss function. The optimum purchaser's order quantity, the producer's product price and the process quality level will be jointly determined by maximising the expected profit between them.

  2. A bio-economic model to improve profitability in a large national beef cattle population

    Directory of Open Access Journals (Sweden)

    Javier López-Paredes

    2017-11-01

    Full Text Available A bio-economic model was developed for estimating economic values for use in improving profitability in a large national beef cattle population from birth to slaughter. Results were divided into fattening costs, production costs and income. Economic values were derived for 17 traits for two regions, mature weight (-0.43 € and -0.38 €/+1 kg of live weight, age at first calving (-0.13 € and -0.11 €/+1d, calving interval (-1.06 € and -1.02 €/+1d, age at last calving (0.03 € and 0.03 €/+1d, mortality 0-48 h (-5.86 € and -5.63 €/1% calves per cow and year, pre-weaning mortality (-5.96 € and -5.73 €/+1% calves per cow and year, fattening mortality (-8.23 € and -7.88 €/+1% calves per cow and year, adult mortality (-8.92 € and -7.34 €/+1% adult cows per cow and year, pre-weaning average daily gain (2.56 € and 2.84 €/+10g/d, fattening young animals average daily gain (2.65 € and 3.00 €/+10g/d, culled cow in fattening average daily gain (0.25 € and 0.16 €/+10g/d, culled cow dressing carcass percentage (3.09 € and 2.42 €/+1%, culled cow price (4.59 € and 3.59 €/+0.06 €/kg, carcass conformation score (16.39 € and 15.3 €/+1 SEUROP class, dressing carcass rate of calf (18.22 € and 18.23 €/+1%, carcass growth (9.00 € and 10.09 €/+10g of carcass weight/d and age at slaughter (0.27 € and 0.44 €/+1d. Two sample herds were used to show the economic impact of calving interval and age at first calving shortening in the profit per slaughtered young animal, which was 178 € and 111 € for Herds A and B, respectively. The economic values of functional traits were reduced and production traits were enhanced when fertility traits were improved. The model could be applied in a Spanish national program.

  3. Harvesting Maturity, Handling, Storage of Okra Pods

    OpenAIRE

    TAMURA, Junsuke; MINAMIDE, Takahisa

    1984-01-01

    The growth pattern of okra pod after flowering was studied in detail. The changes of chemical components and physical properties of okra pod for a period between flowering and harvesting maturity was investigated to determine the optimum harvesting maturity. Storage and handling problems for harvested okra pods were discussed. It was found that the harvesting maturity of okra pod was 4 to 6 days after flowering. The optimum storage temperature of okra pod determined experimentally was at 12℃.

  4. A da Vinci robot system can make sense for a mature laparoscopic prostatectomy program.

    Science.gov (United States)

    Steinberg, Peter L; Merguerian, Paul A; Bihrle, William; Heaney, John A; Seigne, John D

    2008-01-01

    We sought to provide informed recommendations on transitioning from laparoscopic radical prostatectomy (LRP) to robotic-assisted radical prostatectomy (RAP) through a study of the da Vinci robot. We performed a cost-benefit analysis to determine the impact that purchasing a dollars 1.5 million da Vinci robot with a dollars 112,000 service contract per year and dollars 200 per case of disposables would have on profits of a mature laparoscopic prostatectomy program. Seventy-eight cases per year are needed to cover the costs of a purchased robot, while only 20 cases per year are needed if a robot is donated. Once robot costs are covered, increases in caseload lead to increased income. Profit is not feasible at centers performing fewer than 25 cases annually. A donated robot lessens costs and allows reasonable revenue without drastic increases in caseload. Our data suggest a high-volume LRP program can convert to RAP and maintain profits; however, the cost of the robot precludes equal income as that with LRP. Purchasing a robot is not fiscally viable in a low-volume program. Given comparable outcomes between LRP and RAP, hospitals need to decide whether market forces or the intangible benefits of robotics outweigh the expenses of obtaining and operating a robot.

  5. Seeking process maturity with DSDM atern

    Directory of Open Access Journals (Sweden)

    Stasys Peldžius

    2013-09-01

    Full Text Available It is important for an organization to know what capability/maturity of the process a chosen methodology could ensure. This paper is focused on DSDM Atern process maturity by CMMI. The goal is to assess DSDM Atern by CMMI-DEV version 1.3 and propose the improvements to reach CMMI maturity level 3. A capability profile ensured by DSDM Atern has been obtained. The appraisal results showed that DSDM Atern ensures CMMI maturity level 2. Constraints and problematic areas of DSDM Atern methodology were discovered. In order to reach CMMI level 3 some recommendations for DSDM Atern additions were developed.

  6. Can Precision Agriculture Increase the Profitability and Sustainability of the Production of Potatoes and Olives?

    Directory of Open Access Journals (Sweden)

    Frits K. van Evert

    2017-10-01

    Full Text Available For farmers, the application of Precision Agriculture (PA technology is expected to lead to an increase in profitability. For society, PA is expected to lead to increased sustainability. The objective of this paper is to determine for a number of common PA practices how much they increase profitability and sustainability. For potato production in The Netherlands, we considered variable rate application (VRA of soil herbicide, fungicide for late blight control, sidedress N, and haulm killing herbicide. For olive production in Greece, we considered spatially variable application of P and K fertilizer and lime. For each of the above scenarios, we quantified the value of outputs, the cost of inputs, and the environmental costs. This allowed us to calculate profit as well as social profit, where the latter is defined as revenues minus conventional costs minus the external costs of production. Social profit can be considered an overall measure of sustainability. Our calculations show that PA in potatoes increases profit by 21% (420 € ha−1 and social profit by 26%. In olives, VRA application of P, K, and lime leads to a strong reduction in nutrient use and although this leads to an increase in sustainability, it has only a small effect on profit and on social profit. In conclusion, PA increases sustainability in olives and both profitability and sustainability in potatoes.

  7. Profitability diagnosis of refinery and improvement proposal; Seiyusho no shueki shindan to kaizen teian

    Energy Technology Data Exchange (ETDEWEB)

    Aoyama, H.

    2000-07-01

    Based on consulting service RPS-J under joint operation of Nikki, UOP LLC of U.S.A. and Nikki Universal, approaching ways applied for profitability improvement and improvement proposal for refineries and analyzing techniques used for resolution of process bottlenecks were described. In RPS-J, themes of (1) energy saving, (2) quality upgrading, (3) improvement of disintegrating ratio, (4) reduction of give-away, (5) improvement of equipment operation ratio, (6) reduction of maintenance cost, (7) effective utilization of catalysts, are considered for profitability improvement fields. Procedures from idea excavation for profitability improvement to realization of profitability improvement are carried out in the order of, (1) Grasping of the present state, (2) Excavation of improving items and selection, (3) Quantitative evaluation of draft profitability improvement plan and focusing, (4) Profitability improvement by operation improvement, (5) Profitability improvement by minor improvement, (6) Profitability improvement in middle- and long-term vision, (7) Final focusing by feasibility study. Afterwards, examination to economically solve bottlenecks of critical facilities, examination on bottlenecks of distillation tower and refining tower and utility analysis are carried out. RPS-J was already applied to 4 refineries including Muroran Refinery and Negishi Refinery of Nisseki Mitsubishi, and profitability improvement themes were found to improve profitability of 50 to 150 cents per barrel. (NEDO)

  8. Polarity of mature human odontoblasts.

    Science.gov (United States)

    Tjäderhane, L; Koivumäki, S; Pääkkönen, V; Ilvesaro, J; Soini, Y; Salo, T; Metsikkö, K; Tuukkanen, J

    2013-11-01

    Odontoblast polarization is based on histological appearance as columnar cells with asymmetric disposition of organelles and plasma membrane domains. However, little is known about the odontoblast plasma membrane organization. We investigated odontoblast membrane polarity using influenza virus hemagglutinin and vesicular stomatitis virus glycoprotein as model proteins in mature human odontoblast organ culture. We also examined the distribution patterns of aquaporin 4 and 5, which are basolateral and apical proteins in epithelial cells, respectively. Confocal microscopy immunofluorescence and electron microscopy demonstrated that the apical markers located at the surface toward pulp and basolateral markers located at the plasma membrane of odontoblast processes. Therefore, odontoblast plasma membrane polarity was different from that in epithelial cells. Also, certain lectins stained odontoblast processes while others stained the soma, reflecting the different natures of their membrane domains. Strong ZO-1 and weaker claudin expression suggest weak tight junctions in the odontoblasts. TGF-β1 showed a tendency to reinstate the expression of selected TJ genes, indicating that TGF-β1 may control odontoblast cell layer integrity by controlling tight junction protein expression.

  9. Managing competition in the countryside: Non-profit and for-profit perceptions of long-term care in rural Ontario.

    Science.gov (United States)

    Skinner, Mark W; Rosenberg, Mark W

    2006-12-01

    This paper contributes to the current debates surrounding private delivery of health care services by addressing the distinctive challenges, constraints and opportunities facing for-profit and non-profit providers of long-term care in rural and small town settings. It focuses on the empirical case of Ontario, Canada where extensive restructuring of long-term care, under the rubric of managed competition, has been underway since the mid-1990s. In-depth interviews with 72 representatives from local governments, public health institutions and authorities, for-profit and non-profit organisations, and community groups during July 2003 to December 2003 form the platform for a qualitative analysis of the implications of managed competition as it relates to the provision of long-term care in the countryside. The results suggest that the introduction and implementation of managed competition has accentuated the problems of service provision in rural communities, and that the long-standing issues of caregiving in rural situations transcend the differences, perceived or otherwise, between for-profit and non-profit provision. Understanding the implications of market-oriented long-term care restructuring initiatives for providers, and their clients, in rural situations requires a re-focussing of research beyond the for- versus non-profit dichotomy.

  10. Multivariate Analysis of Profitability Indicators for Selected Companies of Croatian Market

    Directory of Open Access Journals (Sweden)

    Ana Perisa

    2017-12-01

    Full Text Available In this paper, the profitability indicators are analysed for the first hundred companies of the Croatian market, which are classified according to the net profit. The profitability indicators included in the analysis are the following: EBIT margin, EBITDA margin, net profit margin, return on assets (ROA, return on invested capital (ROI and return on capital employed (ROCE. By implementing the factor analysis, six chosen profitability indicators have been reduced to two factors, thus solving the multicollinearity problem, which is one of the prerequisites for the cluster analysis. For two extracted factors, the factor scores are calculated and used in the following cluster analysis. By implementing the cluster analysis, selected companies are grouped into clusters according to their similarity in accomplished results that are measured by profitability indicators. The hierarchical and non-hierarchical cluster analyses are conducted and resulted into two clusters where ten companies were in the first cluster, while the other ninety were in the second cluster

  11. The effect of capital structure on the profitability of pharmaceutical companies the case of iran.

    Science.gov (United States)

    Mohammadzadeh, Mehdi; Rahimi, Farimah; Rahimi, Forough; Aarabi, Seyed Mohammad; Salamzadeh, Jamshid

    2013-01-01

    Funding combination is the most important issue for the companies while they know the amount of required capital. Companies should be careful regarding the appliance of financial providing methods compatible with the investment strategy of company and profitability. This study seeks to examine the relationship between the capital structure and the profitability of pharmaceutical companies in Iran. For this purpose, top 30 Iranian pharmaceutical companies defined as study samples and their financial data were gathered for the period of 2001-2010. In this study, the net margin profit and debts to asset ratio were used as indicators of profitability and capital structure, respectively and sales growth was used as a control variable. Results showed that there was significant negative relationship between the profitability and the capital structure which means that the pharmaceutical companies have established a Pecking Order Theory and the internal financing has led to more profitability.

  12. An Analysis of The Islamic and Conventional Banking Profitability in Palestine

    Directory of Open Access Journals (Sweden)

    Mohmad Tawfiq Abusharbeh

    2011-12-01

    Full Text Available Abstract: An Analysis of the Islamic and Conventional Banking Profitability in Palestine. The research paper examines the performance of profitability of Islamic banks against conventional banks for the period of 2005 to 2010. Two alternative measurements of banking profitability such as Return on Equity (ROE and Return on Assets (ROA are used to examine whether there is any differences of profit rate between Islamic, local and foreign conventional banks. The study concludes that Islamic banks generally provide the similar profit rate compared to local banks, however Islamic banks provide lower profit rate compared to foreign banks. Finally the findings also suggest that there is no statistical significant difference in mean return between the Islamic banks, local and foreign banks in Palestine. The study recommends the critical needs for Islamic regulation in order to improve the role of Islamic banking industry in Palestine.

  13. Determinants of Profitability of Food Industry in India: A Size-Wise Analysis

    Directory of Open Access Journals (Sweden)

    Ramachandran Azhagaiah

    2012-01-01

    Full Text Available Profitability is the profit earning capacity, which is a crucial factorin contributing to the survival of firms. This paper is a maidenattempt at estimating the impact of size on profitability, consideringthe ‘size’ as the control variable. For this purpose, the selectedfirms are classified into three size categories as ‘small,’ ‘medium,’and ‘large’ based on the sales turnover. The results show that volatilityand growth are the major predictors in determining profitabilityin case of small size firms while growth is important in determiningthe profitability of medium size firms. Capital intensityhas a significant positive coefficient with the profitability of largesize firms. The overall result shows that the larger the size of thefirm, the more the investment in long lived assets has helped toincrease the profitability of the firm unlike the trend in cases ofsmall size and medium size firms.

  14. Polish and Silesian Non-Profit Organizations Liquidity Strategies

    Directory of Open Access Journals (Sweden)

    Grzegorz Michalski

    2011-12-01

    Full Text Available The kind of realized mission inflows the sensitivity to risk. Among other factors, the risk results from decision about liquid assets investment level and liquid assets financing. The higher the risk exposure, the higher the level of liquid assets. If the specific risk exposure is smaller, the more aggressive could be the net liquid assets strategy. The organization choosing between various solutions in liquid assets needs to decide what level of risk is acceptable for her owners (or donors and / or capital suppliers. The paper shows how, in authors opinion, decisions, about liquid assets management strategy inflow the risk of the organizations and its economicalresults during realization of main mission. Comparison of theoretical model with empirical data for over 450 Silesian nonprofit organization results suggests that nonprofit organization managing teams choose more risky aggressive liquid assets solutions than for-profit firms.

  15. Optimal foraging in marine ecosystem models: selectivity, profitability and switching

    DEFF Research Database (Denmark)

    Visser, Andre W.; Fiksen, Ø.

    2013-01-01

    their diets towards the most profitable prey items. We present a simple algorithm for plankton feeding on a size-spectrum of prey with particular energetic content, handling times and capture probabilities. We show that the optimal diet breadth changes with relative densities, but in a different way...... ecological mechanics and evolutionary logic as a solution to diet selection in ecosystem models. When a predator can consume a range of prey items it has to choose which foraging mode to use, which prey to ignore and which ones to pursue, and animals are known to be particularly skilled in adapting...... to the preference functions commonly used in models today. Indeed, depending on prey class resolution, optimal foraging can yield feeding rates that are considerably different from the ‘switching functions’ often applied in marine ecosystem models. Dietary inclusion is dictated by two optimality choices: 1...

  16. EMOTIONAL INTELLIGENCE AND TRANSFORMATION OF MANAGEMENT EDUCATION FOR ORGANIZATIONAL PROFITABILITY

    Directory of Open Access Journals (Sweden)

    John N. N. Ugoani

    2015-12-01

    Full Text Available Education and training place different demands on institutions and the workforce, as well as the educators themselves. Both education and training are essential to organizational profitability. Clear separation and understanding of management education and training strategy provide advantage but management education curriculum allows educators to concentrate on their essential message to develop the specialized technical and management capacity needed to link training and competencies more closely to the economy and the world of work. This situation has given rise to the refocusing of traditional education practices to involve newly emerging management education concepts that are embedded in the components of emotional intelligence. The survey method was used for the study, and it was found that emotional intelligence has significant positive relationship with management education.

  17. Profitability of smart grid solutions applied in power grid

    Directory of Open Access Journals (Sweden)

    Katić Nenad A.

    2016-01-01

    Full Text Available The idea of a Smart Grid solution has been developing for years, as complete solution for a power utility, consisting of different advanced technologies aimed at improving of the efficiency of operation. The trend of implementing various smart systems continues, e.g. Energy Management Systems, Grid Automation Systems, Advanced Metering Infrastructure, Smart power equipment, Distributed Energy Resources, Demand Response systems, etc. Futhermore, emerging technologies, such as energy storages, electrical vehicles or distributed generators, become integrated in distribution networks and systems. Nowadays, the idea of a Smart Grid solution becomes more realistic by full integration of all advanced operation technologies (OT within IT environment, providing the complete digitalization of an Utility (IT/OT integration. The overview of smart grid solutions, estimation of investments, operation costs and possible benefits are presented in this article, with discusison about profitability of such systems.

  18. Using Cotton Model Simulations to Estimate Optimally Profitable Irrigation Strategies

    Science.gov (United States)

    Mauget, S. A.; Leiker, G.; Sapkota, P.; Johnson, J.; Maas, S.

    2011-12-01

    In recent decades irrigation pumping from the Ogallala Aquifer has led to declines in saturated thickness that have not been compensated for by natural recharge, which has led to questions about the long-term viability of agriculture in the cotton producing areas of west Texas. Adopting irrigation management strategies that optimize profitability while reducing irrigation waste is one way of conserving the aquifer's water resource. Here, a database of modeled cotton yields generated under drip and center pivot irrigated and dryland production scenarios is used in a stochastic dominance analysis that identifies such strategies under varying commodity price and pumping cost conditions. This database and analysis approach will serve as the foundation for a web-based decision support tool that will help producers identify optimal irrigation treatments under specified cotton price, electricity cost, and depth to water table conditions.

  19. Maturational Constraints and First Language Attrition

    Science.gov (United States)

    Bylund, Emanuel

    2009-01-01

    The aim of the article is to examine how first language attrition research on maturational constraints interprets and links its findings to current views on maturation in the field of second language acquisition. It is argued that attrition research exhibits certain inconsistencies in the interpretation of the structural characteristics of the…

  20. Body Mass Index and Sexual Maturation in

    African Journals Online (AJOL)

    Body Mass Index and Sexual Maturation inAdolescent. Patients with Sickle Cell Anaemia. Nigerian Journal of Paediatrim- 2003;30:39. Background: Sickle cell anaemia (SCA) is associated with delayed sexual maturation. The. Body Mass Index (BMI) or Quetelets Index is closely linked to events of puberty in normal children ...

  1. Moving towards maturity in business model definitions

    DEFF Research Database (Denmark)

    Nielsen, Christian; Lund, Morten; Bukh, Per Nikolaj

    2014-01-01

    The field of business models has, as is the case with all emerging fields of practice, slowly matured through the development of frameworks, models, concepts and ideas over the last 15 years. New concepts, theories and models typically transcend a series of maturity phases. For the concept of Bus...

  2. Cone and Seed Maturation of Southern Pines

    Science.gov (United States)

    James P. Barnett

    1976-01-01

    If slightly reduced yields and viability are acceptable, loblolly and slash cone collections can begin 2 to 3 weeks before maturity if the cones are stored before processing. Longleaf(P. palestris Mill.) pine cones should be collected only when mature, as storage decreased germination of seeds from immature cones. Biochemical analyses to determine reducing sugar...

  3. Profitability of Contrarian Strategies in the Chinese Stock Market.

    Directory of Open Access Journals (Sweden)

    Huai-Long Shi

    Full Text Available This paper reexamines the profitability of loser, winner and contrarian portfolios in the Chinese stock market using monthly data of all stocks traded on the Shanghai Stock Exchange and Shenzhen Stock Exchange covering the period from January 1997 to December 2012. We find evidence of short-term and long-term contrarian profitability in the whole sample period when the estimation and holding horizons are 1 month or longer than 12 months and the annualized return of contrarian portfolios increases with the estimation and holding horizons. We perform subperiod analysis and find that the long-term contrarian effect is significant in both bullish and bearish states, while the short-term contrarian effect disappears in bullish states. We compare the performance of contrarian portfolios based on different grouping manners in the estimation period and unveil that decile grouping outperforms quintile grouping and tertile grouping, which is more evident and robust in the long run. Generally, loser portfolios and winner portfolios have positive returns and loser portfolios perform much better than winner portfolios. Both loser and winner portfolios in bullish states perform better than those in the whole sample period. In contrast, loser and winner portfolios have smaller returns in bearish states, in which loser portfolio returns are significant only in the long term and winner portfolio returns become insignificant. These results are robust to the one-month skipping between the estimation and holding periods and for the two stock exchanges. Our findings show that the Chinese stock market is not efficient in the weak form. These findings also have obvious practical implications for financial practitioners.

  4. Profitability of Contrarian Strategies in the Chinese Stock Market.

    Science.gov (United States)

    Shi, Huai-Long; Jiang, Zhi-Qiang; Zhou, Wei-Xing

    2015-01-01

    This paper reexamines the profitability of loser, winner and contrarian portfolios in the Chinese stock market using monthly data of all stocks traded on the Shanghai Stock Exchange and Shenzhen Stock Exchange covering the period from January 1997 to December 2012. We find evidence of short-term and long-term contrarian profitability in the whole sample period when the estimation and holding horizons are 1 month or longer than 12 months and the annualized return of contrarian portfolios increases with the estimation and holding horizons. We perform subperiod analysis and find that the long-term contrarian effect is significant in both bullish and bearish states, while the short-term contrarian effect disappears in bullish states. We compare the performance of contrarian portfolios based on different grouping manners in the estimation period and unveil that decile grouping outperforms quintile grouping and tertile grouping, which is more evident and robust in the long run. Generally, loser portfolios and winner portfolios have positive returns and loser portfolios perform much better than winner portfolios. Both loser and winner portfolios in bullish states perform better than those in the whole sample period. In contrast, loser and winner portfolios have smaller returns in bearish states, in which loser portfolio returns are significant only in the long term and winner portfolio returns become insignificant. These results are robust to the one-month skipping between the estimation and holding periods and for the two stock exchanges. Our findings show that the Chinese stock market is not efficient in the weak form. These findings also have obvious practical implications for financial practitioners.

  5. Increasing Cropping System Diversity Balances Productivity, Profitability and Environmental Health

    Science.gov (United States)

    Davis, Adam S.; Hill, Jason D.; Chase, Craig A.; Johanns, Ann M.; Liebman, Matt

    2012-01-01

    Balancing productivity, profitability, and environmental health is a key challenge for agricultural sustainability. Most crop production systems in the United States are characterized by low species and management diversity, high use of fossil energy and agrichemicals, and large negative impacts on the environment. We hypothesized that cropping system diversification would promote ecosystem services that would supplement, and eventually displace, synthetic external inputs used to maintain crop productivity. To test this, we conducted a field study from 2003–2011 in Iowa that included three contrasting systems varying in length of crop sequence and inputs. We compared a conventionally managed 2-yr rotation (maize-soybean) that received fertilizers and herbicides at rates comparable to those used on nearby farms with two more diverse cropping systems: a 3-yr rotation (maize-soybean-small grain + red clover) and a 4-yr rotation (maize-soybean-small grain + alfalfa-alfalfa) managed with lower synthetic N fertilizer and herbicide inputs and periodic applications of cattle manure. Grain yields, mass of harvested products, and profit in the more diverse systems were similar to, or greater than, those in the conventional system, despite reductions of agrichemical inputs. Weeds were suppressed effectively in all systems, but freshwater toxicity of the more diverse systems was two orders of magnitude lower than in the conventional system. Results of our study indicate that more diverse cropping systems can use small amounts of synthetic agrichemical inputs as powerful tools with which to tune, rather than drive, agroecosystem performance, while meeting or exceeding the performance of less diverse systems. PMID:23071739

  6. Islamic banks:Profit sharing, equity, leverage lure, and credit control

    OpenAIRE

    Hasan, Zubair

    2008-01-01

    This paper deals with three basic issues in Islamic banking: First, how the profit sharing ratios in mudarabah contracts are in principle determined? Second, do the actual sharing ratios result in an equitable division of profit between the banks on the one hand and the depositors on the other? Finally, can the central bank use the profit sharing ratio along with the rate of interest for credit control so as to mitigate leverage lure in a dual banking system? The paper pr...

  7. Business analytics of specialized medical biochemistry laboratory using profit and loss acount

    Directory of Open Access Journals (Sweden)

    Vikica Buljanović

    2011-07-01

    Full Text Available Introduction. By measuring the actual effectiveness of a medical biochemistry laboratory’s business operations, we can determine the accounting measure of laboratory’s profitability, where operating expenses of the laboratory are covered by the income generated from the services. A laboratory’s financial report can be based on a profit and loss account, which shows whether or not a business entity, i.e., the laboratory, is making a profit during a particular business period. Methods. Profitability of the Specialized Medical Biochemical Laboratory (Laboratory of the General County Hospital in Našice, Croatia, was determined using the profit and loss account for 2007. Business success was expressed using the accounting measures of marginal contribution, gross income, and operating income, which could show whether or not the laboratory was operating profitably. This procedure allowed us to identify indicators of successful or unsuccessful business operations of the Laboratory. Results. According to the profit and loss account, the operating profit was 719,926 HRK, i.e., the operating margin was 11.7%, indicating that the Laboratory was operating positively. After subtracting all operating expenses per 100 income units, 11.7 units profit remained from the Laboratory’s core business. Conclusion. The Specialized Medical Biochemical Laboratory of the General County Hospital in Našice generated income, i.e., it operated at a profit. The purpose of profit and loss account was to determine the Laboratory operations that had impact on its business effectiveness and could increase the actual profitability. If the laboratory operates at a loss, and no activities are undertaken that would reverse the business toward positive, the analysis may provide information on the cost for the society as a whole of the studied laboratory within the existing healthcare system.

  8. Home loan profitability optimisation in the financial industry / by Sias Heyns

    OpenAIRE

    Heyns, Sias

    2007-01-01

    Product profitability needs to remain a competitive advantage to a bank's home loan product. Ever changing customer needs and even more demanding customers today enforce reasons to investigate the profitability of home loans. Other aspects to consider includes transfer pricing, ROA, cost to deliver product to market areas (marketing and distribution cost) and break-even period. Banks are facing immense challenges to achieve sustainable profitability. Historically low interest rates are compre...

  9. The Impact of the Financial Crisis on the Islamic Banks Profitability - Evidence from GCC

    OpenAIRE

    Mousa Almanaseer

    2014-01-01

    Using pooled data for 24 Islamic banks operating in Bahrain, Kuwait, Qatar, Saudi Arabia and UAE over the 2005-2012 period the current study examines empirically the impact of the global financial crisis on the Islamic banks¡¯ profitability. The study finds that the financial crisis does not have significant impact on Islamic banks profitability. Favorable macro-economic conditions, bank size and equity capital are important factors in increasing Islamic banks¡¯ profitability. Furthermore Inc...

  10. Internationalization And Profitability Of The U.S. Multinational Companies After The Free Trade Agreement

    OpenAIRE

    Ayse Yuce; Sergiy Rakhmanyil

    2010-01-01

    This paper examines the effect of North American liberalization on the degree of internationalization and profitability of US companies using industry-level data between 1985 and 2005. We find evidence of long-run increases in the degree of internationalization and evidence pointing at increases in firm profitability in the short and long run for US companies following the introduction of NAFTA. We find cross-sectional variation in the degree of internationalization and profitability for US i...

  11. Bank-specific, industry-specific and macroeconomic determinants of bank profitability

    OpenAIRE

    Athanasoglou, Panayiotis; Brissimis, Sophocles; Delis, Matthaios

    2005-01-01

    The aim of this study is to examine the effect of bank-specific, industry-specific and macroeconomic determinants of bank profitability, using an empirical framework that incorporates the traditional Structure-Conduct-Performance (SCP) hypothesis. To account for profit persistence, we apply a GMM technique to a panel of Greek banks that covers the period 1985-2001. The estimation results show that profitability persists to a moderate extent, indicating that departures from perfectly competiti...

  12. EVALUATION OF CUSTOMERS’ PROFITABILITY IN THE ACCOUNTING PRACTICE OF TUZLA CANTON COMPANIES

    OpenAIRE

    Selma Novalija Islambegović; Amra Gadžo

    2015-01-01

    The aim of the paper is to clarify and systematize the methods of evaluating customers’ profitability on a scientifically based methodology. It also aims at investigating the relationship between business results achieved by individual sectors in the companies from the Tuzla Canton (TC) and the applied method of profitability management, in the function of generating such results. The analysis was conducted on the appropriateness of the current approach to profitability management according t...

  13. Profit shifting and 'aggressive' tax planning by multinational firms: Issues and options for reform

    OpenAIRE

    Fuest, Clemens; Spengel, Christoph; Finke, Katharina; Heckemeyer, Jost H.; Nusser, Hannah

    2013-01-01

    This paper discusses the issue of profit shifting and 'aggressive' tax planning by multinational firms. The paper makes two contributions. Firstly, we provide some background information to the debate by giving a brief overview over existing empirical studies on profit shifting and by describing arrangements for IP-based profit shifting which are used by the companies currently accused of avoiding taxes. We then show that preventing this type of tax avoidance is, in principle, straightforward...

  14. THE PROFIT AND LOSS ACCOUNT THROUGH THE ROMANIAN ACCOUNTING REGULATIONS. FROM EUROPEAN TO INTERNATIONAL

    OpenAIRE

    MARIANA MAN; LIANA GĂDĂU

    2011-01-01

    The paper analyses the profit and loss account from the Romanian accounting regulations’ perspective in terms of format, structure, content, which is subject to the approval of OMPF no.3055/2009 harmonized with the European accounting directives. Even if from the name it appears the compliance with the European accounting directives, the Romanian profit and loss account brings elements from the international standard IAS1. Moreover, if we compare the structure of profit and loss account chose...

  15. The Depreciation Impact of the Profit and Activity Development Carried out by an Economic Operator

    OpenAIRE

    Dobrota, Gabriela; Chirculescu, Felicia Maria

    2008-01-01

    It's interesting how an economic operator decides to depreciate its depreciable fixed assets, because depreciation is an expense input from the taxable profit in accordance with the laws in force, thus contributing to diminishing the operating profit/loss and implicitly the gross and net earnings, without real impact on profitability and especially without any impact on the self-funding capacity. But the impact given by the depreciation expenses may be influenced by the organization policy...

  16. Profiting from competition: Financial tools for electric generation companies

    Science.gov (United States)

    Richter, Charles William, Jr.

    Regulations governing the operation of electric power systems in North America and many other areas of the world are undergoing major changes designed to promote competition. This process of change is often referred to as deregulation. Participants in deregulated electricity systems may find that their profits will greatly benefit from the implementation of successful bidding strategies. While the goal of the regulators may be to create rules which balance reliable power system operation with maximization of the total benefit to society, the goal of generation companies is to maximize their profit, i.e., return to their shareholders. The majority of the research described here is conducted from the point of view of generation companies (GENCOs) wishing to maximize their expected utility function, which is generally comprised of expected profit and risk. Strategies that help a GENCO to maximize its objective function must consider the impact of (and aid in making) operating decisions that may occur within a few seconds to multiple years. The work described here assumes an environment in which energy service companies (ESCOs) buy and GENCOs sell power via double auctions in regional commodity exchanges. Power is transported on wires owned by transmission companies (TRANSCOs) and distribution companies (DISTCOs). The proposed market framework allows participants to trade electrical energy contracts via the spot, futures, options, planning, and swap markets. An important method of studying these proposed markets and the behavior of participating agents is the field of experimental/computational economics. For much of the research reported here, the market simulator developed by Kumar and Sheble and similar simulators has been adapted to allow computerized agents to trade energy. Creating computerized agents that can react as rationally or irrationally as a human trader is a difficult problem for which we have turned to the field of artificial intelligence. Some of our

  17. Maturity models in supply chain sustainability

    DEFF Research Database (Denmark)

    Correia, Elisabete; Carvalho, Helena; Azevedo, Susana G.

    2017-01-01

    A systematic literature review of supply chain maturity models with sustainability concerns is presented. The objective is to give insights into methodological issues related to maturity models, namely the research objectives; the research methods used to develop, validate and test them; the scope......; and the main characteristics associated with their design. The literature review was performed based on journal articles and conference papers from 2000 to 2015 using the SCOPUS, Emerald Insight, EBSCO andWeb of Science databases. Most of the analysed papers have as main objective the development of maturity...... on a specific process (eco-design and new product development) and without a broad SC perspective. The dominant characteristics associated with the design of the maturity models are the maturity grids and a continuous representation. In addition, results do not allow identifying a trend for a specific number...

  18. DISPAQ: Distributed Profitable-Area Query from Big Taxi Trip Data.

    Science.gov (United States)

    Putri, Fadhilah Kurnia; Song, Giltae; Kwon, Joonho; Rao, Praveen

    2017-09-25

    One of the crucial problems for taxi drivers is to efficiently locate passengers in order to increase profits. The rapid advancement and ubiquitous penetration of Internet of Things (IoT) technology into transportation industries enables us to provide taxi drivers with locations that have more potential passengers (more profitable areas) by analyzing and querying taxi trip data. In this paper, we propose a query processing system, called Distributed Profitable-Area Query ( DISPAQ ) which efficiently identifies profitable areas by exploiting the Apache Software Foundation's Spark framework and a MongoDB database. DISPAQ first maintains a profitable-area query index (PQ-index) by extracting area summaries and route summaries from raw taxi trip data. It then identifies candidate profitable areas by searching the PQ-index during query processing. Then, it exploits a Z-Skyline algorithm, which is an extension of skyline processing with a Z-order space filling curve, to quickly refine the candidate profitable areas. To improve the performance of distributed query processing, we also propose local Z-Skyline optimization, which reduces the number of dominant tests by distributing killer profitable areas to each cluster node. Through extensive evaluation with real datasets, we demonstrate that our DISPAQ system provides a scalable and efficient solution for processing profitable-area queries from huge amounts of big taxi trip data.

  19. A branch-and-cut algorithm for the capacitated profitable tour problem

    DEFF Research Database (Denmark)

    Jepsen, Mads Kehlet; Petersen, Bjørn; Spoorendonk, Simon

    2014-01-01

    This paper considers the Capacitated Profitable Tour Problem (CPTP) which is a special case of the Elementary Shortest Path Problem with Resource Constraints (ESPPRC). The CPTP belongs to the group of problems known as traveling salesman problems with profits. In CPTP each customer is associated...... with a profit and a demand and the objective is to find a capacitated tour (rooted in a depot node) that minimizes the total travel distance minus the profit of the visited customers. The CPTP can be recognized as the sub-problem in many column generation applications, where it is traditionally solved through...

  20. Business groups and profit redistribution: A boon or bane for firms?

    National Research Council Canada - National Science Library

    George, Rejie; Kabir, Rezaul

    2008-01-01

    This article examines the phenomenon of profit redistribution in Indian business groups and relates redistribution with the underperformance of group-affiliated firms relative to unaffiliated firms...

  1. Determinants of Market Share of For-Profit Hospitals: An Empirical Examination

    Directory of Open Access Journals (Sweden)

    Seungchul Lee

    2017-10-01

    Full Text Available This study estimates the effects of a prospective payment system on the growth of for-profit hospitals. The empirical results show that the proportion of patient care paid for by Medicare managed care has a positive, statistically significant relationship with the market share of for-profit hospitals. Medicare managed care reimburses health care providers prospectively, and a larger portion of prospective reimbursements is received by for-profit hospitals, whose market share consequently increases. In addition, the proportion of patients with Medi-Cal and third party managed care has a positive, statistically significant relationship with the market share of for-profit hospitals.

  2. [Recent knowledge on follicle and oocyte maturation. 2. Oocyte development and maturation].

    Science.gov (United States)

    Sudik, R; Fliess, F R

    1984-01-01

    A review is given about the present knowledge in oocyte development and oocyte maturation. The four parts of the review contain: development of the oocyte in the fetal ovary, morphology and metabolism during meiotic arrest, oocyte maturation, and the relations between oocyte maturation and in vitro-fertilization in the human. The morphological and biochemical changes in the maturation process and present hypotheses about maturation regulation are described especially. The increasing knowledge in this field supports the progress of in vitro-fertilization in the human. On the other hand this technique contributes importantly to new directions in oocyte research.

  3. Late maturers at a performance disadvantage to their more mature peers in junior Australian football.

    Science.gov (United States)

    Gastin, Paul B; Bennett, Gary

    2014-01-01

    Children and adolescents mature at different rates such that individuals competing in the same competition may differ in physical and biological maturity despite being of similar chronological age. Whether or not differences translate into on-field performance in competition is relatively unknown. This study investigated the influence of biological maturity on fitness and match running performance in junior Australian football. Eighty-seven under-15 years players were categorised into early (n = 20), average (n = 45) and late (n = 22) maturity groups based on self-reported and anthropometric assessment of biological maturity. Running movements during competition were collected using GPS (5 Hz) technology. Early maturers were heavier and taller than all other boys (P 14.4 km · h(-1)) running distance and number of high-intensity efforts were significantly greater (20.8%, 53.6%, 31.7%, respectively; P disadvantage to their earlier maturing peers.

  4. Enhancing innovation capability maturity through knowledge conversion

    Directory of Open Access Journals (Sweden)

    D. Esterhuizen

    2011-12-01

    Full Text Available Purpose: This research was aimed at investigating organisational support by means of knowledge conversion processes toward maturity growth in innovation capability areas. Problem investigated: No formal guidelines exist for the use of knowledge management to grow innovation capability maturity. As knowledge management plays a fundamental role in an enterprise's ability to innovate successfully, the following question arises: Can knowledge creation processes be used to enable innovation capability maturity growth? Methodology: The literature therefore provides a strong basis for the argument that knowledge management and more specifically knowledge creation processes could be used to improve an enterprise's innovation capability maturity. A knowledge creation framework that enables innovation capability maturity growth was designed by aligning knowledge creation processes to the requirements for innovation capability growth from one maturity level to the next. The time-frame of the research did not allow the implementation of the framework, and five industry and subject theory experts were used to evaluate the framework. Findings: All five experts responded positively to, and were in agreement that the reasoning applied when identifying the specific knowledge creation process path as a key enabler of growth between innovation capability maturity levels is logical and sound. Value of research: The unique research contribution of the framework lies in providing a tangible link between the fields of knowledge management and innovation capability maturity.Conclusion: The impact of this research lies in the development of a knowledge creation framework that provides guidelines for the use of knowledge creation processes as a vehicle for innovation capability maturity growth.

  5. The postcranial skeletal maturation of Australopithecus sediba.

    Science.gov (United States)

    Cameron, Noel; Bogin, Barry; Bolter, Debra; Berger, Lee R

    2017-07-01

    In 2008, an immature hominin defined as the holotype of the new species Australopithecus sediba was discovered at the 1.9 million year old Malapa site in South Africa. The specimen (MH1) includes substantial post-cranial skeletal material, and provides a unique opportunity to assess its skeletal maturation. Skeletal maturity indicators observed on the proximal and distal humerus, proximal ulna, distal radius, third metacarpal, ilium and ischium, proximal femur and calcaneus were used to assess the maturity of each bone in comparison to references for modern humans and for wild chimpanzees (Pan troglodytes). In comparison to humans the skeletal maturational ages for Au. sediba correspond to between 12.0 years and 15.0 years with a mean (SD) age of 13.1 (1.1) years. In comparison to the maturational pattern of chimpanzees the Au. sediba indicators suggest a skeletal maturational age of 9-11 years. Based on either of these skeletal maturity estimates and the body length at death of MH1, an adult height of 150-156 cm is predicted. We conclude that the skeletal remains of MH1 are consistent with an ape-like pattern of maturity when dental age estimates are also taken into consideration. This maturity schedule in australopiths is consistent with ape-like estimates of age at death for the Nariokotome Homo erectus remains (KMN-WT 15000), which are of similar postcranial immaturity to MH1. The findings suggest that humans may have distinctive and delayed post-cranial schedules from australopiths and H. erectus, implicating a recent evolution of somatic and possibly life history strategies in human evolution. © 2017 Wiley Periodicals, Inc.

  6. Hospital financial management: what is the link between revenue cycle management, profitability, and not-for-profit hospitals' ability to grow equity?

    Science.gov (United States)

    Singh, Simone Rauscher; Wheeler, John

    2012-01-01

    Effective revenue cycle management--from appointment scheduling and patient registration at the front end of the revenue cycle to billing and cash collections at the back end--plays a crucial role in hospitals' efforts to improve their financial performance. Using data for 1,397 bond-issuing, not-for-profit US hospitals for 2000 to 2007, this study analyzed the relationship between hospitals' performance at managing the revenue cycle and their profitability and ability to build equity capital. Hospital-level fixed effects regression analysis was used to model four different measures of profitability and equity capital as functions of two key financial indicators of revenue cycle management--amount of patient revenue and speed of revenue collection. The results indicated that higher amounts of patient revenue in relation to a hospital's assets were associated with statistically significant increases in operating and total profit margins, free cash flow, and equity capital (p profit margins and larger equity values. For revenue cycle managers, these findings represent good news: Streamlining a hospital's management of the patient revenue cycle can advance the organization's financial viability by improving profitability and enabling equity growth.

  7. Dividend and Profit Allocation Practices of Performing Cooperatives in Malaysia

    Directory of Open Access Journals (Sweden)

    Rafedah Juhan

    2012-05-01

    Full Text Available This paper explores the dividend payout and profit allocation practices of performing cooperatives in Malaysia, specifically how net profits were distributed as between dividends and various funds established for the benefit of members, after the necessary statutory deduction has been made. This paper is an exploratory study that is confined to performing co-operatives throughout Malaysia of different sizes and activities. Figures were derived from the 2008, 2007 and 2006 audited annual financial statements provided by the co-operatives themselves. Overall the study revealed that micro co-operatives are found to have paid the highest average dividend payouts, followed by the large co-operatives. Credit co-operatives which have a sizeable amount of shares and subscriptions are observed to have the lowest average dividend payout ratio. The highest dividend payout is given out by the construction and consumer co-operatives. Besides dividends, co-operatives normally allocate part of their annual net profit for the benefit of members in the form of specific funds for members’ social and related purposes. It was observed that in 2007, all co-operatives have increased their allocation towards members’ benefits except for co-operatives in the services sector. In conclusion, the credit, agriculture and industrial co-operatives are the top three functions with the highest level of contribution to members' benefit fund. Este artículo analiza el pago de dividendos y prácticas de reparto de beneficios que siguen las cooperativas de Malasia, específicamente el sistema en los que los beneficios netos, después de realizar las deducciones legales pertinentes, se distribuyen entre dividendos y los fondos creados para el beneficio de los miembros. Se ha realizado un estudio exploratorio que analiza las cooperativas de diferente tamaño y actividad limitadas a Malasia. Los datos se derivan de las auditorías de los años 2008, 2007 y 2006, que presentan las

  8. Delayed visual maturation and lead pollution.

    Science.gov (United States)

    Gulson, B L; Yui, L A; Howarth, D

    1998-12-11

    Three children were born in the Broken Hill Australia lead mining community with delayed visual maturation of the optic nerve (blindness) within a period of 19 months. Because of the association with the lead pollution, the delayed visual maturation was attributed to lead exposure of the fetus during pregnancy. Lead isotopic analyses of the shed deciduous teeth from the three children demonstrate that they were not exposed to increased levels of lead from a mining or any other source during pregnancy and the etiology of the delayed visual maturation must be sought elsewhere.

  9. Service Quality and Process Maturity Assessment

    Directory of Open Access Journals (Sweden)

    Serek Radomir

    2013-12-01

    Full Text Available This article deals with service quality and the methods for its measurement and improvements to reach the so called service excellence. Besides older methods such as SERVQUAL and SERPERF, there are also shortly described capability maturity models based on which the own methodology is developed and used for process maturity assessment in organizations providing technical services. This method is equally described and accompanied by examples on pictures. The verification of method functionality is explored on finding a correlation between service employee satisfaction and average process maturity in a service organization. The results seem to be quite promising and open an arena for further studies.

  10. Graphic representation of skeletal maturity determinations.

    Science.gov (United States)

    Boechat, M Ines; Lee, David Choen

    2007-10-01

    Skeletal maturation determinations are usually reported as numeric data indicating accordance with chronologic age. However, significant changes in skeletal maturation can occur without falling outside two SDs. The purpose of our study was to design simple computer-generated sex-based charts to enhance the evaluation of skeletal maturation, especially when frequent assessments are made. The graphic representation of successive reports clearly depicts whether values retain their position in relation to the mean. In addition, the report includes computation of the exact SD score.

  11. Dusts, scale, slags, sludges... Not wastes, but sources of profits

    Science.gov (United States)

    Koros, Peter J.

    2003-12-01

    Historically, the steel industry has focused on the need for and the many benefits of recycling steel that is discarded either in its own or in its customers’ manufacturing processes, as well as in recovery and reuse of steel scrap that arises after the product has served its intended purpose. In fact, modern steelmaking relies on the use of recycled iron units for at least half of its production. The other side of the story is the fate of the non-steel by-products (e.g., oxide dusts, sludges, scales, slags, spent refractories and the contained “low grade” energy units that are generated as natural adjuncts to iron and steelmaking processes). These valuable by-products often are classified as “wastes” and are discarded to landfills, at significant cost, although in reality they offer significant potential for cost savings or profit if reintroduced into the industrial arena via well planned programs. Examples of such instances will be presented, including energy credit issues, in the hope of pointing the way for future expansion of benefits from these opportunities. Preparing for a challenge and honor such as the Howe Memorial Lecture, one has to stand in awe of the accomplishments of the predecessor we honor in this forum. He worked in the early days of our industry without the benefits of the many technological improvements he and his successors brought to play as the years went by. John Stubbles, in his Howe Memorial Lecture in 1997,[1] presented a masterful and entertaining biography of Howe and his very active and prolific life. Perhaps the most telling quotation he attributed to Howe is very pertinent to the topic we will address presently: “Metallurgy lives by profit, not logic,” to which I would like to add a comment that bears on the topic of this lecture from the 1991 Howe lecturer, my friend and mentor Bill Dennis, “Where there is muck, there is money.” There are numerous examples of “one hand washes the other” in this business; that

  12. Politics or profits? Gazprom, the Kremlin, and Russian energy policy

    Science.gov (United States)

    Swinn, Eric S.

    This paper adds to the ongoing discussion of Gazprom's role in Russia by placing the debate around Gazprom within the broader contexts of both the increasing prevalence of national oil companies in the world and the changing natural gas landscape. It assesses how the interplay between politics and profits has affected the way Gazprom can adapt to a rapidly changing world natural gas environment and how both the Kremlin and Gazprom are adjusting---or failing to adjust---their strategies accordingly. It concludes that Gazprom and the Kremlin are both adjusting to changes in the world natural gas environment, but they are doing so in their own ways, but given the affects the actions of one has on the other, the pace of adaptation is slower than what we might see with an entirely independent firm. The paper begins with a discussion of the tradeoffs inherent in Gazprom's relationship with the Kremlin. It identifies various factors at work politically that prevent Gazprom from profiting in the domestic economy. Primary among these factors are entrenched rent-seeking interests and philosophies about natural resources, as well as geopolitical interests. The paper identifies the 2006 and 2009 gas disputes with Ukraine as evidence of Kremlin interference in Gazprom's commercial activities and concrete examples of the boundaries between these two entities as well as the seeming blurring of these boundaries. The paper then moves into a discussion of increased volatility and risk in Gazprom's primary export market, Europe. The systemic context of a discussion of Gazprom today must include factors such as increased supply options for Europe that make natural gas a more fungible commodity than in the past and new legislation aimed at promoting energy independence via the development of a competitive natural gas market. This new context threatens Gazprom's ability to mitigate price risk in its export market, which in turn makes providing for the domestic market through gas rents

  13. EXAMINATION OF IMPACT OF PHARMA R&D ON PROFITABILITY

    Directory of Open Access Journals (Sweden)

    Gergo Tomori

    2014-07-01

    Full Text Available By today, in our business environment, mostly based on innovation, the potential opportunities in the pharmaceutical sector and impact of these to the national economic trends has a determining significance. This latter requires the examination of the impact of research and development activity as the most important factor to the profitability of two selected regional market leader pharma companies and presentation of how these groups handle their high operating risks which resulting from these investments. National and international importance of the pharmaceutical industry defined by not only the prominent role of application of the biochemical academic research, but the humanitarian concerns which increasingly appreciating in the global context. In the developing and overpopulated countries the risks of become massive epidemics arisen from the emergence viruses which mutating quickly and in increasingly complex forms has risen due to the scientist discoveries and more modernize preventive procedures. These facts – in view of growing efficient immune substances developing procedures – are stronger pressure on the industrial actors, with this affecting the profitability of future operations. The farming specificities and their role can be illustrated well by comparing the activities of the Central European market-leader Richter and the world-renowned Swiss Novartis which ranked number two in sales with approximately 47 billion dollar among the world-wide pharma groups in 2010. Since the comparable figures based on IFRS, it must be also mention that how the international accountant standards display these management areas. Among the examined factors, the pharma R&D activity had the highest impact on the long-term firming both individually and in comparison, but the different of the financial strategy and accounting policy as a kind of asset of risk management had no negligible. My analysis is mostly theoretical and based on quantitative

  14. 26 CFR 1.857-7 - Earnings and profits of a real estate investment trust.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 9 2010-04-01 2010-04-01 false Earnings and profits of a real estate investment... (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Real Estate Investment Trusts § 1.857-7 Earnings and profits of a real estate investment trust. (a) Any real estate investment trust whether or not such trust...

  15. 26 CFR 1.852-12 - Non-RIC earnings and profits.

    Science.gov (United States)

    2010-04-01

    ... (CONTINUED) INCOME TAXES Regulated Investment Companies and Real Estate Investment Trusts § 1.852-12 Non-RIC earnings and profits. (a) Applicability of section 852(a)(2)(A)—(1) In general. An investment company does... profits the investment company succeeded by the operation of section 381, part I of subchapter M applied...

  16. 26 CFR 1.852-5 - Earnings and profits of a regulated investment company.

    Science.gov (United States)

    2010-04-01

    ... (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Regulated Investment Companies and Real Estate Investment Trusts § 1.852-5 Earnings and profits of a regulated investment company. (a) Any regulated investment... 26 Internal Revenue 9 2010-04-01 2010-04-01 false Earnings and profits of a regulated investment...

  17. 26 CFR 1.857-11 - Non-REIT earnings and profits.

    Science.gov (United States)

    2010-04-01

    ... TAX (CONTINUED) INCOME TAXES Real Estate Investment Trusts § 1.857-11 Non-REIT earnings and profits. (a) Applicability of section 857(a)(3)(A). A real estate investment trust does not satisfy section... profits of real estate investment trusts. (d) Effective date. This regulation is effective for taxable...

  18. Professional Educator or Professional Manager? The Contested Role of the For-Profit International School Principal

    Science.gov (United States)

    Machin, Denry

    2014-01-01

    For-profit education is increasingly prevalent within international schooling. The language of client, customer and consumer may not yet be embedded in the classroom, but international school leaders, particularly those operating in for-profit contexts, are having to respond not only to the needs of educational stakeholders but also to the…

  19. 26 CFR 1.381(c)(2)-1 - Earnings and profits.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 4 2010-04-01 2010-04-01 false Earnings and profits. 1.381(c)(2)-1 Section 1.381(c)(2)-1 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES Insolvency Reorganizations § 1.381(c)(2)-1 Earnings and profits. (a) In...

  20. Profitability and constraints in the marketing of poultry birds in Delta ...

    African Journals Online (AJOL)

    The profitability and constraints in the marketing of poultry birds in Delta Central Agricultural Zone were investigated. The study fills the gap in empirical information on the profitability and constraints in the marketing of poultry birds. Randomly selected 54 poultry bird marketers were surveyed in 5 major markets. The primary ...