WorldWideScience

Sample records for profiling system irps

  1. The IRP/IRE system in vivo: insights from mouse models

    Directory of Open Access Journals (Sweden)

    Nicole eWilkinson

    2014-07-01

    Full Text Available Iron regulatory proteins 1 and 2 (IRP1 and IRP2 post-transcriptionally control the expression of several mRNAs encoding proteins of iron, oxygen and energy metabolism. The mechanism involves their binding to iron responsive elements (IREs in the untranslated regions of target mRNAs, thereby controlling mRNA translation or stability. Whereas IRP2 functions solely as an RNA-binding protein, IRP1 operates as either an RNA-binding protein or a cytosolic aconitase. Early experiments in cultured cells established a crucial role of IRPs in regulation of cellular iron metabolism. More recently, studies in mouse models with global or localized Irp1 and/or Irp2 deficiencies uncovered new physiological functions of IRPs in the context of systemic iron homeostasis. Thus, IRP1 emerged as a key regulator of erythropoiesis and iron absorption by controlling hypoxia inducible factor 2α (HIF2α mRNA translation, while IRP2 appears to dominate the control of iron uptake and heme biosynthesis in erythroid progenitor cells by regulating the expression of transferrin receptor 1 (TfR1 and 5-aminolevulinic acid synthase 2 (ALAS2 mRNAs, respectively. Targeted disruption of either Irp1 or Irp2 in mice is associated with distinct phenotypic abnormalities. Thus, Irp1-/- mice develop polycythemia and pulmonary hypertension, while Irp2-/- mice present with microcytic anemia, iron overload in the intestine and the liver, and neurologic defects. Combined disruption of both Irp1 and Irp2 is incombatible with life and leads to early embryonic lethality. Mice with intestinal- or liver-specific disruption of both Irps are viable at birth but die later on due to malabsorption or liver failure, respectively. Adult mice lacking both Irps in the intestine exhibit a profound defect in dietary iron absorption due to a mucosal block that is caused by the de-repression of ferritin mRNA translation. Herein, we discuss the physiological function of the IRE/IRP regulatory system.

  2. Tumorigenic properties of iron regulatory protein 2 (IRP2) mediated by its specific 73-amino acids insert.

    Science.gov (United States)

    Maffettone, Carmen; Chen, Guohua; Drozdov, Ignat; Ouzounis, Christos; Pantopoulos, Kostas

    2010-04-13

    Iron regulatory proteins, IRP1 and IRP2, bind to mRNAs harboring iron responsive elements and control their expression. IRPs may also perform additional functions. Thus, IRP1 exhibited apparent tumor suppressor properties in a tumor xenograft model. Here we examined the effects of IRP2 in a similar setting. Human H1299 lung cancer cells or clones engineered for tetracycline-inducible expression of wild type IRP2, or the deletion mutant IRP2(Delta73) (lacking a specific insert of 73 amino acids), were injected subcutaneously into nude mice. The induction of IRP2 profoundly stimulated the growth of tumor xenografts, and this response was blunted by addition of tetracycline in the drinking water of the animals, to turnoff the IRP2 transgene. Interestingly, IRP2(Delta73) failed to promote tumor growth above control levels. As expected, xenografts expressing the IRP2 transgene exhibited high levels of transferrin receptor 1 (TfR1); however, the expression of other known IRP targets was not affected. Moreover, these xenografts manifested increased c-MYC levels and ERK1/2 phosphorylation. A microarray analysis identified distinct gene expression patterns between control and tumors containing IRP2 or IRP1 transgenes. By contrast, gene expression profiles of control and IRP2(Delta73)-related tumors were more similar, consistently with their growth phenotype. Collectively, these data demonstrate an apparent pro-oncogenic activity of IRP2 that depends on its specific 73 amino acids insert, and provide further evidence for a link between IRPs and cancer biology.

  3. Tumorigenic properties of iron regulatory protein 2 (IRP2 mediated by its specific 73-amino acids insert.

    Directory of Open Access Journals (Sweden)

    Carmen Maffettone

    2010-04-01

    Full Text Available Iron regulatory proteins, IRP1 and IRP2, bind to mRNAs harboring iron responsive elements and control their expression. IRPs may also perform additional functions. Thus, IRP1 exhibited apparent tumor suppressor properties in a tumor xenograft model. Here we examined the effects of IRP2 in a similar setting. Human H1299 lung cancer cells or clones engineered for tetracycline-inducible expression of wild type IRP2, or the deletion mutant IRP2(Delta73 (lacking a specific insert of 73 amino acids, were injected subcutaneously into nude mice. The induction of IRP2 profoundly stimulated the growth of tumor xenografts, and this response was blunted by addition of tetracycline in the drinking water of the animals, to turnoff the IRP2 transgene. Interestingly, IRP2(Delta73 failed to promote tumor growth above control levels. As expected, xenografts expressing the IRP2 transgene exhibited high levels of transferrin receptor 1 (TfR1; however, the expression of other known IRP targets was not affected. Moreover, these xenografts manifested increased c-MYC levels and ERK1/2 phosphorylation. A microarray analysis identified distinct gene expression patterns between control and tumors containing IRP2 or IRP1 transgenes. By contrast, gene expression profiles of control and IRP2(Delta73-related tumors were more similar, consistently with their growth phenotype. Collectively, these data demonstrate an apparent pro-oncogenic activity of IRP2 that depends on its specific 73 amino acids insert, and provide further evidence for a link between IRPs and cancer biology.

  4. IRP methods for Environmental Impact Statements of utility expansion plans

    International Nuclear Information System (INIS)

    Cavallo, J.D.; Hemphill, R.C.; Veselka, T.D.

    1992-01-01

    Most large electric utilities and a growing number of gas utilities in the United States are using a planning method -- Integrated Resource Planning (IRP) - which incorporates demand-side management (DSM) programs whenever the marginal cost of the DSM programs are lower than the marginal cost of supply-side expansion options. Argonne National Laboratory has applied the IRP method in its socio-economic analysis of an Environmental Impact Statement (EIS) of power marketing for a system of electric utilities in the mountain and western regions of the United States. Applying the IRP methods provides valuable information to the participants in an EIS process involving capacity expansion of an electric or gas utility. The major challenges of applying the IRP method within an EIS are the time consuming and costly task of developing a least cost expansion path for each altemative, the detailed quantification of environmental damages associated with capacity expansion, and the explicit inclusion of societal-impacts to the region

  5. IAEA safeguards information system re-engineering project (IRP)

    International Nuclear Information System (INIS)

    Whitaker, G.; Becar, J.-M.; Ifyland, N.; Kirkgoeze, R.; Koevesd, G.; Szamosi, L.

    2007-01-01

    The Safeguards Information System Re-engineering Project (IRP) was initiated to assist the IAEA in addressing current and future verification and analysis activities through the establishment of a new information technology framework for strengthened and integrated safeguards. The Project provides a unique opportunity to enhance all of the information services for the Department of Safeguards and will require project management 'best practices' to balance limited funds, available resources and Departmental priorities. To achieve its goals, the Project will require the participation of all stakeholders to create a comprehensive and cohesive plan that provides both a flexible and stable foundation for address changing business needs. The expectation is that high quality integrated information systems will be developed that incorporate state-of-the-art technical architectural standards, improved business processes and consistent user interfaces to store various data types in an enterprise data repository which is accessible on-line in a secure environment. (author)

  6. Abnormal brain iron metabolism in Irp2 deficient mice is associated with mild neurological and behavioral impairments.

    Directory of Open Access Journals (Sweden)

    Kimberly B Zumbrennen-Bullough

    Full Text Available Iron Regulatory Protein 2 (Irp2, Ireb2 is a central regulator of cellular iron homeostasis in vertebrates. Two global knockout mouse models have been generated to explore the role of Irp2 in regulating iron metabolism. While both mouse models show that loss of Irp2 results in microcytic anemia and altered body iron distribution, discrepant results have drawn into question the role of Irp2 in regulating brain iron metabolism. One model shows that aged Irp2 deficient mice develop adult-onset progressive neurodegeneration that is associated with axonal degeneration and loss of Purkinje cells in the central nervous system. These mice show iron deposition in white matter tracts and oligodendrocyte soma throughout the brain. A contrasting model of global Irp2 deficiency shows no overt or pathological signs of neurodegeneration or brain iron accumulation, and display only mild motor coordination and balance deficits when challenged by specific tests. Explanations for conflicting findings in the severity of the clinical phenotype, brain iron accumulation and neuronal degeneration remain unclear. Here, we describe an additional mouse model of global Irp2 deficiency. Our aged Irp2-/- mice show marked iron deposition in white matter and in oligodendrocytes while iron content is significantly reduced in neurons. Ferritin and transferrin receptor 1 (TfR1, Tfrc, expression are increased and decreased, respectively, in the brain from Irp2-/- mice. These mice show impairments in locomotion, exploration, motor coordination/balance and nociception when assessed by neurological and behavioral tests, but lack overt signs of neurodegenerative disease. Ultrastructural studies of specific brain regions show no evidence of neurodegeneration. Our data suggest that Irp2 deficiency dysregulates brain iron metabolism causing cellular dysfunction that ultimately leads to mild neurological, behavioral and nociceptive impairments.

  7. Tumorigenic Properties of Iron Regulatory Protein 2 (IRP2) Mediated by Its Specific 73-Amino Acids Insert

    OpenAIRE

    Maffettone, Carmen; Chen, Guohua; Drozdov, Ignat; Ouzounis, Christos; Pantopoulos, Kostas

    2010-01-01

    Iron regulatory proteins, IRP1 and IRP2, bind to mRNAs harboring iron responsive elements and control their expression. IRPs may also perform additional functions. Thus, IRP1 exhibited apparent tumor suppressor properties in a tumor xenograft model. Here we examined the effects of IRP2 in a similar setting. Human H1299 lung cancer cells or clones engineered for tetracycline-inducible expression of wild type IRP2, or the deletion mutant IRP2(Delta73) (lacking a specific insert of 73 amino acid...

  8. Achieving energy efficiency in restructured markets, implications for IRP

    International Nuclear Information System (INIS)

    Giraldo, J.M.M.

    1997-01-01

    The shift of the focus of the vertically integrated model to the new unbundled models of organization to attain a ''new competitive'' Electricity Supply Industry brings new subjects into IRP (Integrated Resource Planning) study. The decision centralization on new capacity additions is being substituted by market mechanisms, changing the implementation of the IRP regarding both the construction of new capacity and the DSM. The implication for DSM is that, without a central planning process, it will not be possible to carry out IRP. In some countries they are implementing policies tending to create a more favourable attitude towards energy efficiency, in products and services. The conventional programmes of Demand-Side Management are being redesigned as added-value services to conserve or create market quota through Market Transformation mechanisms, such as Technology Procurement. (author)

  9. 10 CFR 905.14 - Does Western require annual IRP progress reports?

    Science.gov (United States)

    2010-01-01

    ... Section 905.14 Energy DEPARTMENT OF ENERGY ENERGY PLANNING AND MANAGEMENT PROGRAM Integrated Resource Planning § 905.14 Does Western require annual IRP progress reports? Yes, customers must submit IRP progress... projected goals and implementation schedules, and energy and capacity benefits and renewable energy...

  10. Shemya AFB, Alaska 1992 IRP field investigation report

    Energy Technology Data Exchange (ETDEWEB)

    1993-02-01

    The US Air Force is currently investigating 22 sites on Shemya Air Force Base (AFB) to determine if past spill and disposal activities have caused environmental damage. These investigations are being carried out under the Air Force's Installation Restoration Program (IRP). As a part of the IRP program, field investigations were performed in 1992 to obtain the information needed to assess what future actions willneed to be carried out at each site. The island's drinking water supply was also investigated. Activities completed at 10 selected sites during the 1992 field investigation included surface sampling to determine the lateral extent of contamination, subsurface sampling to determine the vertical extent of contamination, and the installation of well points and monitoring wells to determine the direction of groundwater flow and if the groundwater has been affected by a site. In addition, geophysical surveys were performed at most sites to identify site boundaries and check for the presence of buried metal to be avoided during drilling activities.

  11. Shemya AFB, Alaska 1992 IRP field investigation report

    Energy Technology Data Exchange (ETDEWEB)

    1993-02-01

    The US Air Force is currently investigating 22 sites on Shemya Air Force Base (AFB) to determine if past spill and disposal activities have caused environmental damage. These investigations are being carried out under the Air Force's Installation Restoration Program (IRP). Field investigations were performed in 1992 to obtain the information needed to assess what future actions will need to be carried out at each site. The island's drinking water supply was also investigated. Activities completed at 10 selected sites included surface sampling to determine the lateral extent of contamination, subsurface sampling to determine the vertical extent of contamination, and the installation of well points and monitoring wells to determine the direction of groundwater flow and if the groundwater has been affected by a site. Geophysical surveys were performed at most sites to identify site boundaries and check for the presence of buried metal to be avoided during drilling activities. This report, appendices B, C, and D contains information on the following: geophysical contour maps and profile plots; human health risk assessment; and ecological risk assessment.

  12. 10 CFR 905.11 - What must an IRP include?

    Science.gov (United States)

    2010-01-01

    ..., energy conservation and efficiency, cogeneration and district heating and cooling applications, and..., consumer preferences, environmental impacts, demand or energy impacts, implementation issues, revenue... 10 Energy 4 2010-01-01 2010-01-01 false What must an IRP include? 905.11 Section 905.11 Energy...

  13. Iron insufficiency compromises motor neurons and their mitochondrial function in Irp2-null mice

    KAUST Repository

    Jeong, Suh Young; Crooks, Daniel R.; Wilson-Ollivierre, Hayden; Ghosh, Manik C.; Sougrat, Rachid; Lee, Jaekwon; Cooperman, Sharon; Mitchell, James B.; Beaumont, Carole; Rouault, Tracey A.

    2011-01-01

    Genetic ablation of Iron Regulatory Protein 2 (Irp2, Ireb2), which post-transcriptionally regulates iron metabolism genes, causes a gait disorder in mice that progresses to hind-limb paralysis. Here we have demonstrated that misregulation of iron metabolism from loss of Irp2 causes lower motor neuronal degeneration with significant spinal cord axonopathy. Mitochondria in the lumbar spinal cord showed significantly decreased Complex I and II activities, and abnormal morphology. Lower motor neurons appeared to be the most adversely affected neurons, and we show that functional iron starvation due to misregulation of iron import and storage proteins, including transferrin receptor 1 and ferritin, may have a causal role in disease. We demonstrated that two therapeutic approaches were beneficial for motor neuron survival. First, we activated a homologous protein, IRP1, by oral Tempol treatment and found that axons were partially spared from degeneration. Secondly, we genetically decreased expression of the iron storage protein, ferritin, to diminish functional iron starvation. These data suggest that functional iron deficiency may constitute a previously unrecognized molecular basis for degeneration of motor neurons in mice.

  14. Iron insufficiency compromises motor neurons and their mitochondrial function in Irp2-null mice

    KAUST Repository

    Jeong, Suh Young

    2011-10-07

    Genetic ablation of Iron Regulatory Protein 2 (Irp2, Ireb2), which post-transcriptionally regulates iron metabolism genes, causes a gait disorder in mice that progresses to hind-limb paralysis. Here we have demonstrated that misregulation of iron metabolism from loss of Irp2 causes lower motor neuronal degeneration with significant spinal cord axonopathy. Mitochondria in the lumbar spinal cord showed significantly decreased Complex I and II activities, and abnormal morphology. Lower motor neurons appeared to be the most adversely affected neurons, and we show that functional iron starvation due to misregulation of iron import and storage proteins, including transferrin receptor 1 and ferritin, may have a causal role in disease. We demonstrated that two therapeutic approaches were beneficial for motor neuron survival. First, we activated a homologous protein, IRP1, by oral Tempol treatment and found that axons were partially spared from degeneration. Secondly, we genetically decreased expression of the iron storage protein, ferritin, to diminish functional iron starvation. These data suggest that functional iron deficiency may constitute a previously unrecognized molecular basis for degeneration of motor neurons in mice.

  15. Iron insufficiency compromises motor neurons and their mitochondrial function in Irp2-null mice.

    Directory of Open Access Journals (Sweden)

    Suh Young Jeong

    Full Text Available Genetic ablation of Iron Regulatory Protein 2 (Irp2, Ireb2, which post-transcriptionally regulates iron metabolism genes, causes a gait disorder in mice that progresses to hind-limb paralysis. Here we have demonstrated that misregulation of iron metabolism from loss of Irp2 causes lower motor neuronal degeneration with significant spinal cord axonopathy. Mitochondria in the lumbar spinal cord showed significantly decreased Complex I and II activities, and abnormal morphology. Lower motor neurons appeared to be the most adversely affected neurons, and we show that functional iron starvation due to misregulation of iron import and storage proteins, including transferrin receptor 1 and ferritin, may have a causal role in disease. We demonstrated that two therapeutic approaches were beneficial for motor neuron survival. First, we activated a homologous protein, IRP1, by oral Tempol treatment and found that axons were partially spared from degeneration. Secondly, we genetically decreased expression of the iron storage protein, ferritin, to diminish functional iron starvation. These data suggest that functional iron deficiency may constitute a previously unrecognized molecular basis for degeneration of motor neurons in mice.

  16. Shemya AFB, Alaska 1992 IRP field investigation report. Volume 1: Final report

    Energy Technology Data Exchange (ETDEWEB)

    1993-02-01

    The US Air Force is currently investigating 22 sites on Shemya Air Force Base (AFB) to determine if past spill and disposal activities have caused environmental damage. These investigations are being carried out under the Air Force`s Installation Restoration Program (IRP). As a part of the IRP program, field investigations were performed in 1992 to obtain the information needed to assess what future actions willneed to be carried out at each site. The island`s drinking water supply was also investigated. Activities completed at 10 selected sites during the 1992 field investigation included surface sampling to determine the lateral extent of contamination, subsurface sampling to determine the vertical extent of contamination, and the installation of well points and monitoring wells to determine the direction of groundwater flow and if the groundwater has been affected by a site. In addition, geophysical surveys were performed at most sites to identify site boundaries and check for the presence of buried metal to be avoided during drilling activities.

  17. Formal comments on the Integrated Resource Plan (IRP) Update Assumptions, Base Case and Observations 2016

    CSIR Research Space (South Africa)

    Wright, Jarrad

    2017-03-01

    Full Text Available capacity and electricity supplied excludes pumped storage; Renewables include solar PV, CSP, wind, biomass, biogas, landfill and hydro (includes imports). Sources: DoE IRP 2010-2030; CSIR Energy Centre analysis Coal (new) Nuclear (new) Coal Other Nuclear... energy system relies on domestic coal and imported oil Simplified energy-flow diagram (Sankey diagram) for South Africa in 2014 in PJ Coal 6 200 Nuclear 151 Oil 897 Natural Gas 161 Renewables 661 Power Plants 2 829 Heat 1 503 Transport 749 Liquefaction...

  18. Occurrence and analysis of irp2 virulence gene in isolates of Klebsiella pneumoniae and Enterobacter spp. from microbiota and hospital and community-acquired infections.

    Science.gov (United States)

    Souza Lopes, Ana Catarina; Rodrigues, Juliana Falcão; Cabral, Adriane Borges; da Silva, Maíra Espíndola; Leal, Nilma Cintra; da Silveira, Vera Magalhães; de Morais Júnior, Marcos Antônio

    2016-07-01

    Eighty-five isolates of Klebsiella pneumoniae and Enterobacter spp., originating from hospital- and community-acquired infections and from oropharyngeal and faecal microbiota from patients in Recife-PE, Brazil, were analyzed regarding the presence of irp2 gene. This is a Yersinia typical gene involved in the synthesis of siderophore yersiniabactin. DNA sequencing confirmed the identity of irp2 gene in five K. pneumoniae, five Enterobacter aerogenes and one Enterobacter amnigenus isolates. To our knowledge in the current literature, this is the first report of the irp2 gene in E. amnigenus, a species considered an unusual human pathogen, and in K. pneumoniae and E. aerogenes isolates from the normal microbiota and from community infections, respectively. Additionally, the analyses of nucleotide and amino acid sequences suggest the irp2 genes derived from isolates used in this study are more closely related to that of Yersinia pestis P.CE882 than to that of Yersinia enterocolitica 8081. These data demonstrated that K. pneumoniae and Enterobacter spp. from normal microbiota and from community- and hospital-acquired infections possess virulence factors important for the establishment of extra-intestinal infections. Copyright © 2016 Elsevier Ltd. All rights reserved.

  19. Functionality of the approach of hierarchical analysis in the full cost accounting in the IRP of a metropolitan airport

    International Nuclear Information System (INIS)

    Cicone, Decio; Morales Udaeta, Miguel Edgar; Aquiles Baesso Grimoni, Jose; Ribeiro Galvao, Luiz Claudio

    2008-01-01

    This work shows the application of the analytic hierarchy process (AHP) in the full cost accounting (FCA) within the integrated resource planning (IRP) process. For this purpose, a pioneer case was developed and different energy solutions of supply and demand for a metropolitan airport (Congonhas) were considered [Moreira, E.M., 2005. Modelamento energetico para o desenvolvimento limpo de aeroporto metropolitano baseado na filosofia do PIR-O caso da metropole de Sao Paulo. Dissertacao de mestrado, GEPEA/USP]. These solutions were compared and analyzed utilizing the software solution 'Decision Lens' that implements the AHP. The final part of this work has a classification of resources that can be considered to be the initial target as energy resources, thus facilitating the restraints of the IRP of the airport and setting parameters aiming at sustainable development

  20. Progressive IRP Models for Power Resources Including EPP

    Directory of Open Access Journals (Sweden)

    Yiping Zhu

    2017-01-01

    Full Text Available In the view of optimizing regional power supply and demand, the paper makes effective planning scheduling of supply and demand side resources including energy efficiency power plant (EPP, to achieve the target of benefit, cost, and environmental constraints. In order to highlight the characteristics of different supply and demand resources in economic, environmental, and carbon constraints, three planning models with progressive constraints are constructed. Results of three models by the same example show that the best solutions to different models are different. The planning model including EPP has obvious advantages considering pollutant and carbon emission constraints, which confirms the advantages of low cost and emissions of EPP. The construction of progressive IRP models for power resources considering EPP has a certain reference value for guiding the planning and layout of EPP within other power resources and achieving cost and environmental objectives.

  1. Preinspection of nuclear power plant systems

    International Nuclear Information System (INIS)

    1975-01-01

    The general plans of the systems affecting the safety of the nuclear power plants are accepted by the Institute of Radiation Protection (IRP) on the basis of the preinspection of the systems. This is the prerequisite of the preinspection of the structures and components belonging to these systems. Exceptionally, when separately agreed, the IRP may perform the preinspection of a separate structure or component, although the preinspection documentation of the whole system, e.g. the nuclear heat generating system, has not been accepted. This guide applies to the nuclear power plant systems that have been defined to be preinspected in the classification document accepted by the IRP

  2. Shemya AFB, Alaska 1992 IRP field investigation report. Volume 3, Appendixes B, C, and D: Final report

    Energy Technology Data Exchange (ETDEWEB)

    1993-02-01

    The US Air Force is currently investigating 22 sites on Shemya Air Force Base (AFB) to determine if past spill and disposal activities have caused environmental damage. These investigations are being carried out under the Air Force`s Installation Restoration Program (IRP). Field investigations were performed in 1992 to obtain the information needed to assess what future actions will need to be carried out at each site. The island`s drinking water supply was also investigated. Activities completed at 10 selected sites included surface sampling to determine the lateral extent of contamination, subsurface sampling to determine the vertical extent of contamination, and the installation of well points and monitoring wells to determine the direction of groundwater flow and if the groundwater has been affected by a site. Geophysical surveys were performed at most sites to identify site boundaries and check for the presence of buried metal to be avoided during drilling activities. This report, appendices B, C, and D contains information on the following: geophysical contour maps and profile plots; human health risk assessment; and ecological risk assessment.

  3. Shemya AFB, Alaska 1992 IRP field investigation report

    Energy Technology Data Exchange (ETDEWEB)

    1993-02-01

    The US Air Force is currently investigating 22 sites on Shemya Air Force Base (AFB) to determine if past spill and disposal activities have caused environmental damage. These investigations are being carried out under the Air Force's Installation Restoration Program (IRP). Field investigations were performed in 1992 to obtain the information needed to assess what future actions will need to be carried out at each site. The island's drinking water supply was also investigated. Activities completed at 10 selected sites included surface sampling to determine the lateral extent of contamination, subsurface sampling to determine the vertical extent of contamination, and the installation of well points and monitoring wells to determine the direction of groundwater flow and if the groundwater has been affected by a site. In addition, geophysical surveys were performed at most sites to identify site boundaries and check for the presence of buried metal, to be avoided during drilling activities. This report contains appendices E and F with information on the following: soil boring logs, and data validation of samples analyzed.

  4. Scoping study of integrated resource planning needs in the public utility sector

    Energy Technology Data Exchange (ETDEWEB)

    Garrick, C J; Garrick, J M; Rue, D R [NEOS Corp., Lakewood, CO (United States)

    1993-06-01

    Integrated resource planning (IRP) is an approach to utility resource planning that integrates the evaluation of supply- and demand-site options for providing energy services at the least cost. Many utilities practice IRP; however, most studies about IRP focus on investor-owned utilities (IOUs). This scoping study investigates the IRP activities and needs of public utilities (not-for-profit utilities, including federal, state, municipal, and cooperative utilities). This study (1) profiles IRP-related characteristics of the public utility sector, (2) articulates the needs of public utilities in understanding and implementing IRP, and (3) identifies strategies to advance IRP principles in public utility planning.

  5. Association of pro-inflammatory cytokines and iron regulatory protein 2 (IRP2 with Leishmania burden in canine visceral leishmaniasis.

    Directory of Open Access Journals (Sweden)

    Paulo Ricardo Porfírio do Nascimento

    Full Text Available Leishmania infantum infection in humans and dogs can evolve with a wide range of clinical presentations, varying from asymptomatic infections to visceral leishmaniasis. We hypothesized that the immune response elicited by L. infantum infection could modulate whether the host will remain asymptomatic or progress to disease. A total of 44 dogs naturally infected with L. infantum were studied. Leishmania burden was estimated in the blood and spleen by qPCR. The expression of IFN-γ, TNF-α, IL-10 and Iron Regulatory Protein 2 (IRP2 were determined in the spleen by quantitative PCR. Sera cytokines were evaluated by ELISA. Dogs were grouped in quartiles according parasite burden. Increased expression of IFN-γ and TNF-α was associated with reduced Leishmania burden, whereas increased IL-10 and IRP2 expressions were associated with higher Leishmania load. Increased plasma albumin and IFN-γ expression explained 22.8% of the decrease in parasite burden in the spleen. These data confirm that lower IFN-γ response and higher IL-10 correlated with increased parasite load and severity of the visceral leishmaniasis in dogs. The balance between the branches of immune response and the intracellular iron availability could determine, in part, the course of Leishmania infection.

  6. Regulatory System of Radiation Protection in Taiwan

    International Nuclear Information System (INIS)

    Tang, F. T.; Huang, C. C.

    2004-01-01

    After the radioactive contaminated buildings incident occurred in Taiwan in 1993, the competent authority for radiation protection the Atomic Energy Council (AEC) started to review the structured problem of radiation protection regulatory system. Through several years' investigation and study, the AEC has improved two important tools in radiation protection regulatory system, i.e., control regulations and actual practice, and made them more rigorous and efficient. This paper will make a brief introduction of the efforts that Taiwan has made in this respect. Taiwan's radiation protection control was based on the Atomic Energy Law promulgated in 1968, but the control idea and authorization scope were not sufficient to appropriately respond to the highly developed economy and democracy in Taiwan. After several years' legislative process, the Ionizing Radiation Protection Law (IRP Law) was promulgated and entered into force on February 1, 2003. This IRP Law specifically emphasizes categorized risk management of radiation sources, establishment of personnel licenses and training system, enhancement of public safety control, and implementation of quality assurance program for medical exposure. The Legislative Yuan (Congress) fully authorized the competent authority to establish various technological control regulations according to control necessity without prior review by the Legislative Yuan in advance. As to the penalties of the violations of the IRP Law, the AEC adopts high-rated administrative fines and applies the Criminal Law to those who seriously contaminate the environment. In actual practice, the AEC has constructed a Radiation Protection Control Information System compatible with the IRP Law that fully combines the functions of computers and Internet. The information of facility operators who own radiation sources, radiation protection specialists, and operating personnel are entered into this system, starting from the submission of application of the

  7. Integrated resource planning-concepts and principles

    Energy Technology Data Exchange (ETDEWEB)

    Atkinson, S.

    1994-12-31

    The concepts and principles of integrated resource planning (IRP) are outlined. The following topics are discussed: utility opportunities and methodologies, application considerations, ambitious energy-efficient programs, the future of IRP, three methods to study resource alternatives, the load adjustment method, simultaneous optimization, static analysis, utility profile data, load forecasts and shapes, load data, conversion, variable costs, external analysis, internal analysis, DSM objectives, supply-side prescreening, DSM screening analysis, DSM evaluation, the IRP process, risk analysis, collaborative planning process, and load shape objectives.

  8. The physiological functions of iron regulatory proteins in iron homeostasis - an update

    Directory of Open Access Journals (Sweden)

    De-Liang eZhang

    2014-06-01

    Full Text Available Iron regulatory proteins (IRPs regulate the expression of genes involved in iron metabolism by binding to RNA stem-loop structures known as iron responsive elements (IREs in target mRNAs. IRP binding inhibits the translation of mRNAs that contain an IRE in the 5’untranslated region of the transcripts, and increases the stability of mRNAs that contain IREs in the 3'untranslated region of transcripts. By these mechanisms, IRPs increase cellular iron absorption and decrease storage and export of iron to maintain an optimal intracellular iron balance. There are two members of the mammalian IRP protein family, IRP1 and IRP2, and they have redundant functions as evidenced by the embryonic lethality of the mice that completely lack IRP expression (Irp1-/-/Irp2-/- mice, which contrasts with the fact that Irp1-/- and Irp2-/- mice are viable. In addition, Irp2-/- mice also display neurodegenerative symptoms and microcytic hypochromic anemia, suggesting that IRP2 function predominates in the nervous system and erythropoietic homeostasis. Though the physiological significance of IRP1 had been unclear since Irp1-/- animals were first assessed in the early 1990’s, recent studies indicate that IRP1 plays an essential function in orchestrating the balance between erythropoiesis and bodily iron homeostasis. Additionally, Irp1-/- mice develop pulmonary hypertension, and they experience sudden death when maintained on an iron-deficient diet, indicating that IRP1 has a critical role in the pulmonary and cardiovascular systems. This review summarizes recent progress that has been made in understanding the physiological roles of IRP1 and IRP2, and further discusses the implications for clinical research on patients with idiopathic polycythemia, pulmonary hypertension and neurodegeneration.

  9. Effects of 12 metal ions on iron regulatory protein 1 (IRP-1) and hypoxia-inducible factor-1 alpha (HIF-1α) and HIF-regulated genes

    International Nuclear Information System (INIS)

    Li Qin; Chen Haobin; Huang Xi; Costa, Max

    2006-01-01

    Several metal ions that are carcinogenic affect cellular iron homeostasis by competing with iron transporters or iron-regulated enzymes. Some metal ions can mimic a hypoxia response in cells under normal oxygen tension, and induce expression of HIF-1α-regulated genes. This study investigated whether 12 metal ions altered iron homeostasis in human lung carcinoma A549 cells as measured by an activation of IRP-1 and ferritin level. We also studied hypoxia signaling by measuring HIF-1α protein levels, hypoxia response element (HRE)-driven luciferase reporter activity, and Cap43 protein level (an HIF-1α responsive gene). Our results show the following: (i) Ni(II), Co(II), V(V), Mn(II), and to a lesser extent As(III) and Cu(II) activated the binding of IRP-1 to IRE after 24 h, while the other metal ions had no effect; (ii) 10 of 12 metal ions induced HIF-1α protein but to strikingly different degrees. Two of these metal ions, Al(III) and Cd(II), did not induce HIF-1α protein; however, as indicated below, only Ni(II), Co (II), and to lesser extent Mn(II) and V(V) activated HIF-1α-dependent transcription. The combined effects of both [Ni(II) + As(III)] and [Ni(II) + Cr(VI)] on HIF-1α protein were synergistic; (iii) Addition of Fe(II) with Ni(II), Co(II), and Cr(VI) attenuated the induction of HIF-1α after 4 h treatment; (iv) Ni(II), Co(II), and Mn(II) significantly decrease ferritin level after 24 h exposure; (v) Ni(II), Co(II), V(V), and Mn(II) activated HRE reporter gene after 20 h treatment; (vi) Ni(II), Co(II), V(V), and Mn(II) increased the HIF-1-dependent Cap43 protein level after 24 h treatment. In conclusion, only Ni (II), Co (II), and to a lesser extent Mn(II) and V(V) significantly stabilized HIF-1α protein, activated IRP, decreased the levels of ferritin, induced the transcription of HIF-dependent reporter, and increased the expression of Cap43 protein levels (HIF-dependent gene). The mechanism for the significant stabilization and elevation of HIF-1

  10. Shemya AFB, Alaska 1992 IRP field investigation report. Volume 4, Appendixes E and F: Final report

    Energy Technology Data Exchange (ETDEWEB)

    1993-02-01

    The US Air Force is currently investigating 22 sites on Shemya Air Force Base (AFB) to determine if past spill and disposal activities have caused environmental damage. These investigations are being carried out under the Air Force`s Installation Restoration Program (IRP). Field investigations were performed in 1992 to obtain the information needed to assess what future actions will need to be carried out at each site. The island`s drinking water supply was also investigated. Activities completed at 10 selected sites included surface sampling to determine the lateral extent of contamination, subsurface sampling to determine the vertical extent of contamination, and the installation of well points and monitoring wells to determine the direction of groundwater flow and if the groundwater has been affected by a site. In addition, geophysical surveys were performed at most sites to identify site boundaries and check for the presence of buried metal, to be avoided during drilling activities. This report contains appendices E and F with information on the following: soil boring logs, and data validation of samples analyzed.

  11. Iron-regulated proteins (IRPS of leptospira biflexa serovar Patoc strain Patoc I

    Directory of Open Access Journals (Sweden)

    Sritharan M

    2004-01-01

    Full Text Available BACKGROUND: Iron deficiency has been shown to induce the expression of siderophores and their receptors, the iron-regulated membrane proteins in a number of bacterial systems. In this study, the response of Leptospira biflexa serovar Patoc strain Patoc I to conditions of iron deprivation was assessed and the expression of siderophores and iron-regulated proteins is reported. MATERIALS AND METHODS: Two methods were used for establishing conditions of iron deprivation. One method consisted of addition of the iron chelators ethylenediamine-N, N′-diacetic acid (EDDA and ethylenediamine di-o-hydroxyphenylacetic acid (EDDHPA and the second method involved the addition of iron at 0.02 µg Fe/mL. Alternatively, iron sufficient conditions were achieved by omitting the chelators in the former method and adding 4 µg Fe/mL of the medium in the latter protocol. Triton X-114 extraction of the cells was done to isolate the proteins in the outer membrane (detergent phase, periplasmic space (aqueous phase and the protoplasmic cylinder (cell pellet. The proteins were subjected to SDS-PAGE for analysis. RESULTS: In the presence of the iron-chelators, four iron-regulated proteins (IRPs of apparent molecular masses of 82, 64, 60 and 33 kDa were expressed. The 82-kDa protein was seen only in the aqueous phase, while the other three proteins were seen in both the aqueous and detergent fractions. These proteins were not identified in organisms grown in the absence of the iron chelators. The 64, 60 and the 33 kDa proteins were also demonstrated in organisms grown in media with 0.02 µg Fe/mL. In addition, a 24 kDa protein was found to be down-regulated at this concentration of iron as compared to the high level of expression in organisms grown with 4 µg Fe/mL. The blue CAS agar plates with top agar containing 0.02µg Fe/mL showed a colour change to orange-red. CONCLUSION: The expression of siderophores and iron-regulated proteins under conditions of iron deprivation

  12. Producción a nivel de laboratorio de Clostridium septicum IRP15 para la formulación de una vacuna veterinaria

    Directory of Open Access Journals (Sweden)

    María Lorena González Ramírez

    Full Text Available Objetivo: establecer las condiciones de producción a nivel de laboratorio de la alfa toxina de Clostridium septicum IRP15 para la formulación de una vacuna veterinaria y la optimización del proceso de producción. Métodos: se caracterizó y estandarizó la edad apropiada del inóculo para los cultivos en un fermentador New Brunswick Scientific 7 L. Las condiciones de cultivo fueron: cepa C. septicum IRP15, medio de cultivo VBH, 5 L/vaso de 7 L, inóculo de 250 mL (5 %, 37 ºC, 24 h, bajo agitaciones prueba de 0, 25 y 50 r.p.m. Se estableció el perfil cinético morfológico, de biomasa, consumo de sustrato y producción de toxina. Resultados: para las fermentaciones de 0 y 25 r.p.m. no se presentó fase de adaptación; el microorganismo creció de manera exponencial hasta las 4 y 6 h de fermentación, consumiendo simultáneamente la mayor cantidad de glucosa presente en el medio. A partir de estas horas y hasta las 24, se realizó la prueba de DL50 en ratones y se destaca que a 25 r.p.m. se obtuvo el mayor título de toxina (1/23. En las fermentaciones a 50 r.p.m. se observó que el microorganismo experimenta una fase de adaptación de 4 h aproximadamente; con un retardo en producción de biomasa, consumo de glucosa y producción de toxina, condición que no resulta óptima para la producción del antígeno. Conclusiones: la producción de toxina se presenta en la fase logarítmica y durante la fase estacionaria, asociándose así al crecimiento y al fenómeno de esporulación.

  13. PECULIARITIES OF CONSTRUCTION PROFILES OF SECURITY SYSTEMS OF INFORMATION SYSTEMS

    Directory of Open Access Journals (Sweden)

    Olga V. Lukinova

    2015-01-01

    Full Text Available Examines the specific issues of building functional and technological profiles of the security systems to ensure the safety of information systems in the paradigm of functional standardization; shows a view of the system of protection based on the model of OSE/RM; studied the composition and structure of the concept of "defense mechanism" for the purpose of profiling third instalment correction representation of the system of protection.

  14. Adaptive Sensing Based on Profiles for Sensor Systems

    Directory of Open Access Journals (Sweden)

    Yoshiteru Ishida

    2009-10-01

    Full Text Available This paper proposes a profile-based sensing framework for adaptive sensor systems based on models that relate possibly heterogeneous sensor data and profiles generated by the models to detect events. With these concepts, three phases for building the sensor systems are extracted from two examples: a combustion control sensor system for an automobile engine, and a sensor system for home security. The three phases are: modeling, profiling, and managing trade-offs. Designing and building a sensor system involves mapping the signals to a model to achieve a given mission.

  15. Design of control system for profile gauge

    International Nuclear Information System (INIS)

    Huang Yibin; Zhang Yu'ai

    2013-01-01

    The profile gauge can on-line get the cross section in the steel strip, so it has been widely used in hot continuous rolling production-line. The structure of profile gauge and its distributed hardware structure based on PLC and software design of its control subsystem were introduced. The method of temperature and humidity measurement was analyzed. The time response of X-ray machine control based on RS232 communication was researched. It is proved that the control system meets the requirements of the profile gauge system. (authors)

  16. Soil Temperature and Moisture Profile (STAMP) System Handbook

    Energy Technology Data Exchange (ETDEWEB)

    Cook, David R. [Argonne National Lab. (ANL), Argonne, IL (United States)

    2016-11-01

    The soil temperature and moisture profile system (STAMP) provides vertical profiles of soil temperature, soil water content (soil-type specific and loam type), plant water availability, soil conductivity, and real dielectric permittivity as a function of depth below the ground surface at half-hourly intervals, and precipitation at one-minute intervals. The profiles are measured directly by in situ probes at all extended facilities of the SGP climate research site. The profiles are derived from measurements of soil energy conductivity. Atmospheric scientists use the data in climate models to determine boundary conditions and to estimate the surface energy flux. The data are also useful to hydrologists, soil scientists, and agricultural scientists for determining the state of the soil. The STAMP system replaced the SWATS system in early 2016.

  17. Evaluation of pharmacokinetics and pharmacodynamics relationships for Salvianolic Acid B micro-porous osmotic pump pellets in angina pectoris rabbit

    Directory of Open Access Journals (Sweden)

    Shu-Ling Kan

    2014-06-01

    Full Text Available The work aims to investigate the in vitro release, pharmacokinetics (PK, pharmacodynamics (PD and PK–PD relationships of Salvianolic Acid B micro-porous osmotic pump pellets (SalB-MPOPs in angina pectoris New Zealand White (NZW rabbits, compared with those of SalB immediate-release pellets (SalB-IRPs. The SalB plasma concentrations and Superoxide dismutase levels (PD index were recorded continuously at predetermined time interval after administration, and the related parameters were calculated by using WinNonlin software. The release profile of MPOPs was more sustained than that of IRPs. PK results indicated that the mean Cmax was significantly lower, the SalB plasma concentrations were steadier, both area under concentration-time curve from 0 to 24 h (AUC0–24 h and from 0 to infinity (AUC0–∞ were presented larger, and both the peak concentration time (Tmax and mean residence time (MRT were prolonged for MPOPs, as compared with those of IRPs. PD results suggested that peak drug effect (Emax was lower and the equilibration rate constant (ke0 between the central compartment and the effect compartment was higher of MPOPs vs. those of IRPs. PK–PD relationships demonstrated that the effect-concentration-time (ECT course of MPOPs was clockwise hysteresis loop, and that of IRPs was counter-clockwise hysteresis loop. Collectively, those results demonstrated that MPOPs were potential formulations in treating angina pectoris induced by atherosclerosis.

  18. Real-time beam profile imaging system for actinotherapy accelerator

    International Nuclear Information System (INIS)

    Lin Yong; Wang Jingjin; Song Zheng; Zheng Putang; Wang Jianguo

    2003-01-01

    This paper describes a real-time beam profile imaging system for actinotheraphy accelerator. With the flash X-ray imager and the technique of digital image processing, a real-time 3-dimension dosage image is created from the intensity profile of the accelerator beam in real time. This system helps to obtain all the physical characters of the beam in any section plane, such as FWHM, penumbra, peak value, symmetry and homogeneity. This system has been used to acquire a 3-dimension dosage distribution of dynamic wedge modulator and the transient process of beam dosage. The system configure and the tested beam profile images are also presented

  19. Video profile monitor diagnostic system for GTA

    International Nuclear Information System (INIS)

    Sandoval, D.P.; Garcia, R.C.; Gilpatrick, J.D.; Johnson, K.F.; Shinas, M.A.; Wright, R.; Yuan, V.; Zander, M.E.

    1992-01-01

    This paper describes a video diagnostic system used to measure the beam profile and position of the Ground Test Accelerator 2.5-MeV H - ion beam as it exits the intermediate matching section. Inelastic collisions between H-ions and residual nitrogen to fluoresce. The resulting light is captured through transport optics by an intensified CCD camera and is digitized. Real-time beam-profile images are displayed and stored for detailed analysis. Analyzed data showing resolutions for both position and profile measurements will also be presented

  20. Development of Cold Neutron Depth Profiling System at HANARO

    International Nuclear Information System (INIS)

    Park, B. G.; Choi, H. D.; Sun, G. M.

    2012-01-01

    The depth profiles of intentional or intrinsic constituents of a sample provide valuable information for the characterization of materials. A number of analytical techniques for depth profiling have been developed. Neutron Depth Profiling (NDP) system which was developed by Ziegler et al. is one of the leading analytical techniques. In NDP, a thermal or cold neutron beam passes through a material and interacts with certain isotopes that are known to emit monoenergetic-charged particle remaining a recoil nucleus after neutron absorption. The depth is obtained from the energy loss of those charged particles escaping surface of substrate material. For various applications of NDP technique, the Cold Neutron Depth Profiling System (CN-NDP) was developed at a neutron guide CG1 installed at the HANARO cold neutron source. In this study the design features of the cold neutron beam and target chamber for the CN-NDP system are given. Also, some experiments for the performance tests of the CN-NDP system are described

  1. Integrated Unmanned Air-Ground Robotics System, Volume 4

    Science.gov (United States)

    2001-08-20

    3) IPT Integrated Product Team IRP Intermediate Power Rating JAUGS TBD JCDL TBD Joint Vision 2020 TBD Km Kilometer lbs. pounds MAE Mechanical and...compatible with emerging JCDL and/or JAUGS . 2.3.2.2. Payload must be “plug and play.” 2.3.3. Communications 2.3.3.1. System communications shall be robust...Power JCDL JAUGS Joint Architecture for Unmanned Ground Systems JP-8 Jet Propulsion Fuel 8 km Kilometer lbs. Pounds LOS Line Of Sight MAE Mechanical

  2. Smoothing out the volatility of South Africa’s wind and PV energy resources for an increased share of renewables

    CSIR Research Space (South Africa)

    Mushwana, C

    2015-11-01

    Full Text Available wind and PV power profiles for different spatial distributions in South Africa Generate data sets that can be used for various studies (IEP, IRP, TDP, SEA etc.) Resulting in: • Confidence in integrating higher renewables shares • Optimal mix...

  3. Video profile monitor diagnostic system for GTA

    International Nuclear Information System (INIS)

    Sandovil, D.P.; Garcia, R.C.; Gilpatrick, J.D.; Johnson, K.F.; Shinas, M.A.; Wright, R.; Yuan, V.; Zander, M.E.

    1992-01-01

    This paper describes a video diagnostic system used to measure the beam profile and position of the Ground Test Accelerator 2.5 MeV H - ion beam as it exits the intermediate matching section. Inelastic collisions between H - ions and residual nitrogen in the vacuum chamber cause the nitrogen to fluoresce. The resulting light is captured through transport optics by an intensified CCD camera and is digitized. Real-time beam profile images are displayed and stored for detailed analysis. Analyzed data showing resolutions for both position and profile measurements will also be presented. (Author) 5 refs., 7 figs

  4. Discrete Model Reference Adaptive Control System for Automatic Profiling Machine

    Directory of Open Access Journals (Sweden)

    Peng Song

    2012-01-01

    Full Text Available Automatic profiling machine is a movement system that has a high degree of parameter variation and high frequency of transient process, and it requires an accurate control in time. In this paper, the discrete model reference adaptive control system of automatic profiling machine is discussed. Firstly, the model of automatic profiling machine is presented according to the parameters of DC motor. Then the design of the discrete model reference adaptive control is proposed, and the control rules are proven. The results of simulation show that adaptive control system has favorable dynamic performances.

  5. Methods and Tools for Profiling and Control of Distributed Systems

    Directory of Open Access Journals (Sweden)

    Sukharev Roman

    2017-01-01

    Full Text Available The article analyzes and standardizes methods for profiling distributed systems that focus on simulation to conduct experiments and build a graph model of the system. The theory of queueing networks is used for simulation modeling of distributed systems, receiving and processing user requests. To automate the above method of profiling distributed systems the software application was developed with a modular structure and similar to a SCADA-system.

  6. Random-Profiles-Based 3D Face Recognition System

    Directory of Open Access Journals (Sweden)

    Joongrock Kim

    2014-03-01

    Full Text Available In this paper, a noble nonintrusive three-dimensional (3D face modeling system for random-profile-based 3D face recognition is presented. Although recent two-dimensional (2D face recognition systems can achieve a reliable recognition rate under certain conditions, their performance is limited by internal and external changes, such as illumination and pose variation. To address these issues, 3D face recognition, which uses 3D face data, has recently received much attention. However, the performance of 3D face recognition highly depends on the precision of acquired 3D face data, while also requiring more computational power and storage capacity than 2D face recognition systems. In this paper, we present a developed nonintrusive 3D face modeling system composed of a stereo vision system and an invisible near-infrared line laser, which can be directly applied to profile-based 3D face recognition. We further propose a novel random-profile-based 3D face recognition method that is memory-efficient and pose-invariant. The experimental results demonstrate that the reconstructed 3D face data consists of more than 50 k 3D point clouds and a reliable recognition rate against pose variation.

  7. The Navy’s Environmental Program and Opportunities in the Southwest

    Science.gov (United States)

    2013-08-27

    Achieve RIP for all High Priority IRP Sites FY14 •Achieve RC for 90% of IRP + MRP Sites FY18 •Achieve RC for 95% of IRP + MRP Sites FY21 9 NAVFAC Southwest...8/21/2013 ER,N IRP vs. MRP ($M) NAVFAC SW 0 10 20 30 40 50 60 70 FY 13 FY 14 FY 15 FY 16 FY 17 FY 18 FY 19 FY 20 FY 21 4 4 7 7 7 43 54 42 51...50 57 58 58 51 18 15 11 9 MRP IRP 10 NAVFAC Southwest Southwest ER,N Requirements Overall CTC: $766M ~54% IRP; ~46% MRP IRP , $411 MRP

  8. Voltage and Frequency Control for Future Power Systems: the ELECTRA IRP Proposal

    DEFF Research Database (Denmark)

    D’hulst, R.; Merino Fernandez, J.; Rikos, E.

    2015-01-01

    In this paper a high level functional architecture for frequency and voltage control for the future (2030+) power system is presented. The proposal suggests a decomposition of the present organization of power system operation into a ”web of cells”. Each cell in this web is managed by a single...

  9. Applications of nutrient profiling: potential role in diet-related chronic disease prevention and the feasibility of a core nutrient-profiling system.

    Science.gov (United States)

    Sacks, G; Rayner, M; Stockley, L; Scarborough, P; Snowdon, W; Swinburn, B

    2011-03-01

    A number of different nutrient-profiling models have been proposed and several applications of nutrient profiling have been identified. This paper outlines the potential role of nutrient-profiling applications in the prevention of diet-related chronic disease (DRCD), and considers the feasibility of a core nutrient-profiling system, which could be modified for purpose, to underpin the multiple potential applications in a particular country. The 'Four 'P's of Marketing' (Product, Promotion, Place and Price) are used as a framework for identifying and for classifying potential applications of nutrient profiling. A logic pathway is then presented that can be used to gauge the potential impact of nutrient-profiling interventions on changes in behaviour, changes in diet and, ultimately, changes in DRCD outcomes. The feasibility of a core nutrient-profiling system is assessed by examining the implications of different model design decisions and their suitability to different purposes. There is substantial scope to use nutrient profiling as part of the policies for the prevention of DRCD. A core nutrient-profiling system underpinning the various applications is likely to reduce discrepancies and minimise the confusion for regulators, manufacturers and consumers. It seems feasible that common elements, such as a standard scoring method, a core set of nutrients and food components, and defined food categories, could be incorporated as part of a core system, with additional application-specific criteria applying. However, in developing and in implementing such a system, several country-specific contextual and technical factors would need to be balanced.

  10. Exergy Rate Profile of Multicomponent Distillation System

    Directory of Open Access Journals (Sweden)

    Kehinde Adewale Adesina

    2016-07-01

    Full Text Available Exergy rate profiles, exergetic efficiency and irreversibility were used to examine the driving forces in multicomponent distillation system with the view to identifying feasible and efficient operating parameters. The mixture used comprised of 5% propane, 15% iso-butane, 25% nbutane, 20% iso-pentane and 35% n-pentane. Operating variables were feed temperature (-30 oC and -80 oC, pressure (800 kPa and 1200 kPa, and reflux-ratio (2 and 6. Stage-by-stage system exergy analysis was estimated. Column profiles of base case -30 oC, -80 oC, -30 oC-reflus ratio 6, -80 oC reflux ratio 6 and base case reflux ratio 6 did not crossed thus are thermodynamically feasible. Base case -30 oC-reflux ratio 2, -80 oC-reflux ratio 2, and base case-reflux ratio 2 were crossed and constricted and are infeasible. Base case results gave efficiency of 81.7% at depropanizer and 65.2% at debutanizer. Base cases sensitivity results with -30 oC, -80 oC and reflux ratio 6, efficiency range 57.40 – 70% and 65.20% - 54.90% for depropanizer and debutanizer respectively. Spitted cases gave 81.7% and 62.20% with more scatter profiles. Splitted feed base case -30 oC design gave the lowest overall system exergy loss rate of 1.12E+6 and efficiency of 95.70%. Design feasible parameters, system efficiency and irreversibility which form basis

  11. Profile updating for information systems

    International Nuclear Information System (INIS)

    Abrantes, J.F.

    1983-02-01

    Profiles updating methods were analysed. A method suitable to the characteristics of the system used in the research (SDI/CIN/CNEN) that uses as the selection criterio the threshold and weights criterion, was determined. Relevance weighting theory was described and experiments to verify precision were carried out. The improvements obtained were good nevertheless more significant tests are required to attain more reliable results. (Author) [pt

  12. Optical bi-sensorial measurement system for production control of extruded profiles

    Science.gov (United States)

    Weckenmann, A.; Bernstein, J.

    2008-09-01

    Extruded profiles are semi-finished products (made out of steel, brass, aluminum, synthetics...) which are appointed for wide applications in manufacturing of technical products. As yet used optical sensors in process control working to the shading technology detect the object's shadow orthographically to the axis of illumination. As a consequence they record it unattached by the profiles coat in measurement range at any point of the measured profile with high precision. As a matter of fact, concave zones cannot be captured. Alternatively the measurement of concave zones can be arranged by light-section systems. These do not comply with the required accuracy, are comparatively slow and moreover affected by dislocations of the section of the profile. A measurement system including a light-section and a shading system combines the advantages of both optical systems. It is to serve with a reliable conception for the assembly of a bi-sensorial measurement system consisting of both systems as well as suitable methods of analysis for the in-line inspection of concave profiles. As a result it contains conclusions concerning requirements of the light source, the arrangement of this source and the cameras, obtainable precision and sampling rate as well as the essential synchronization of both systems. After designing an appropriate prototype, the selected light-section system and the shading system will be synchronized and aligned. Therefore, the metered geometrical data will be merged for the evaluation of form deviation. So, developed and adapted software supports and contains proposals to the uncertainty after successful tests. The system and a calibration method will be proved in production where robustness will be a most critical despite of heat, dust and vibrations. The target uncertainty of less than 0.1 mm at every section of the profiles coat has to be met.

  13. A case report of spontaneous mutation (C33>U) in the iron-responsive element of L-ferritin causing hyperferritinemia-cataract syndrome.

    LENUS (Irish Health Repository)

    Cao, Wei

    2010-01-15

    The hereditary hyperferritinemia cataract syndrome (HHCS) is an autosomal dominant disorder characterized by juvenile-onset cataracts and elevated serum ferritin levels. It is caused by mutation in the iron response element (IRE) within the 5\\'UTR of L-ferritin gene. The mutation results in a loss of post-transcriptional negative feedback exerted by the interaction between iron regulatory proteins 1, 2 (IRP1 and IRP2) and IRE, which leads to uncontrolled expression of L-ferritin. In this paper, we describe the molecular pathogenesis of non-hereditary hyperferritinemia cataract syndrome (non-H-HCS) in a patient with typical HHCS ocular lens morphology and high ferritin levels without obvious family history. Initial sequencing of the full-length L-ferritin cloned from genomic DNA demonstrated a mutation (C33>T) in the IRE of the affected patient but not in her unaffected family members. The mutation (C\\/T heterozygote) was also detected in cDNA derived from her blood mononuclear cells. Structure-prediction-modeling indicates that this mutation would significantly alter the secondary structure of the IRE, resulting in a loss of the interaction between IRP and IRE. By using IRP1\\/IRP2-human IgG1 Fc fusion proteins, we established a novel in vitro report system (modified ELISA) to verify impaired IRE\\/IRP binding. Both the C33>U and A40G mutations (the first identified mutation for HHCS) showed a dramatically decreased binding to IRP1\\/IRP2 protein, compared to the normal IRE RNA. Surprisingly, a decrease in L-ferritin mRNA levels was observed in the affected patient compared to controls suggesting a mechanism of transcriptional negative feedback by high intracellular L-ferritin protein levels not described heretofore. Taken together, spontaneous mutation in the IRE of L-ferritin may cause non-H-HCS by the same mechanism as HHCS. In addition, under abnormal circumstances, the protein level of L-ferritin may be principally controlled by post

  14. Automated design system for a rotor with an ellipse lobe profile

    International Nuclear Information System (INIS)

    Jung, Sung Yuen; Kim Chul; Han, Seung Moo; Cho, Hae Yong

    2009-01-01

    An internal lobe pump (ILP) is suitable for machine tool oil hydraulics, automotive engines, compressors, and various other devices. In particular, the ILP is an essential component of an automotive engine, used to feed lubricant oil through the system. The main components of an ILP are its rotors. The outer rotor is typically characterized by lobes with an elliptical shape, and the inner rotor profile is a conjugate to the outer profile. This paper describes a theoretical analysis of an ILP and the development of an integrated automated system for rotor design. This system is composed of three main modules and has been developed using AutoLISP for the AutoCAD program. The system generates a new lobe profile and automatically calculates flow rate and flow rate irregularity according to the lobe profile generated. Results obtained from the analysis can enable oil pump designers and manufacturers to become more efficient

  15. Automated design system for a rotor with an ellipse lobe profile

    Energy Technology Data Exchange (ETDEWEB)

    Jung, Sung Yuen; Kim Chul [Pusan National University, Busan (Korea, Republic of); Han, Seung Moo [Kyung Hee University, Seoul (Korea, Republic of); Cho, Hae Yong [Chungbuk National University, Cheongju (Korea, Republic of)

    2009-11-15

    An internal lobe pump (ILP) is suitable for machine tool oil hydraulics, automotive engines, compressors, and various other devices. In particular, the ILP is an essential component of an automotive engine, used to feed lubricant oil through the system. The main components of an ILP are its rotors. The outer rotor is typically characterized by lobes with an elliptical shape, and the inner rotor profile is a conjugate to the outer profile. This paper describes a theoretical analysis of an ILP and the development of an integrated automated system for rotor design. This system is composed of three main modules and has been developed using AutoLISP for the AutoCAD program. The system generates a new lobe profile and automatically calculates flow rate and flow rate irregularity according to the lobe profile generated. Results obtained from the analysis can enable oil pump designers and manufacturers to become more efficient

  16. Electron density profile in multilayer systems

    International Nuclear Information System (INIS)

    Toekesi, K.

    2004-01-01

    Complete text of publication follows. Electron energy loss spectroscopy (EELS) has been used extensively to study the multilayer systems, where the thickness of layers are in the nanometer range. These studies has received considerable attention because of its technological interest, for example in the nanotechnology. On the most fundamental level, its importance is derived from the basic physics that is involved. One key quantities of interest is the response of a many-body system to an external perturbation: How act and how modify the interface between the solid-solid or solid-vacuum the excitations in the solid and in the vicinity of the interfaces. In this work, as a starting point of such investigations we calculated the electron density profile for multilayer systems. Our approach employs the time-dependent density functional theory (TDDFT), that is, the solution of a time-dependent Schroedinger equation in which the potential and forces are determined selfconsistently from the dynamics governed by the Schroedinger equation. We treat the problem in TDDFT at the level of the local-density approximation (LDA). Later, the comparison of experimentally obtained loss functions and the theory, based on our TDDFT calculations can provide deeper understanding of surface physics. We performed the calculations for half-infinite samples characterized by r s =1.642 and r s =1.997. We also performed the calculations for double layer systems. The substrate was characterized by r s =1.997 and the coverage by r s =1.642. Fig. 1. shows the obtained electron density profile in LDA approximation. Because of the sharp cutoff of electronic wave vectors at the Fermi surface, the densities in the interior exhibit slowly decaying Friedel oscillations. To highlight the Friedel oscillation we enlarged the electron density profile in Fig. 1a. and Fig. 1b. The work was supported by the Hungarian Scientific Research Found: OTKA No. T038016, the grant 'Bolyai' from the Hungarian Academy of

  17. RNA-Binding Proteins in Trichomonas vaginalis: Atypical Multifunctional Proteins

    Directory of Open Access Journals (Sweden)

    Elisa E. Figueroa-Angulo

    2015-11-01

    Full Text Available Iron homeostasis is highly regulated in vertebrates through a regulatory system mediated by RNA-protein interactions between the iron regulatory proteins (IRPs that interact with an iron responsive element (IRE located in certain mRNAs, dubbed the IRE-IRP regulatory system. Trichomonas vaginalis, the causal agent of trichomoniasis, presents high iron dependency to regulate its growth, metabolism, and virulence properties. Although T. vaginalis lacks IRPs or proteins with aconitase activity, possesses gene expression mechanisms of iron regulation at the transcriptional and posttranscriptional levels. However, only one gene with iron regulation at the transcriptional level has been described. Recently, our research group described an iron posttranscriptional regulatory mechanism in the T. vaginalis tvcp4 and tvcp12 cysteine proteinase mRNAs. The tvcp4 and tvcp12 mRNAs have a stem-loop structure in the 5'-coding region or in the 3'-UTR, respectively that interacts with T. vaginalis multifunctional proteins HSP70, α-Actinin, and Actin under iron starvation condition, causing translation inhibition or mRNA stabilization similar to the previously characterized IRE-IRP system in eukaryotes. Herein, we summarize recent progress and shed some light on atypical RNA-binding proteins that may participate in the iron posttranscriptional regulation in T. vaginalis.

  18. RNA-Binding Proteins in Trichomonas vaginalis: Atypical Multifunctional Proteins.

    Science.gov (United States)

    Figueroa-Angulo, Elisa E; Calla-Choque, Jaeson S; Mancilla-Olea, Maria Inocente; Arroyo, Rossana

    2015-11-26

    Iron homeostasis is highly regulated in vertebrates through a regulatory system mediated by RNA-protein interactions between the iron regulatory proteins (IRPs) that interact with an iron responsive element (IRE) located in certain mRNAs, dubbed the IRE-IRP regulatory system. Trichomonas vaginalis, the causal agent of trichomoniasis, presents high iron dependency to regulate its growth, metabolism, and virulence properties. Although T. vaginalis lacks IRPs or proteins with aconitase activity, possesses gene expression mechanisms of iron regulation at the transcriptional and posttranscriptional levels. However, only one gene with iron regulation at the transcriptional level has been described. Recently, our research group described an iron posttranscriptional regulatory mechanism in the T. vaginalis tvcp4 and tvcp12 cysteine proteinase mRNAs. The tvcp4 and tvcp12 mRNAs have a stem-loop structure in the 5'-coding region or in the 3'-UTR, respectively that interacts with T. vaginalis multifunctional proteins HSP70, α-Actinin, and Actin under iron starvation condition, causing translation inhibition or mRNA stabilization similar to the previously characterized IRE-IRP system in eukaryotes. Herein, we summarize recent progress and shed some light on atypical RNA-binding proteins that may participate in the iron posttranscriptional regulation in T. vaginalis.

  19. RNA-Binding Proteins in Trichomonas vaginalis: Atypical Multifunctional Proteins Involved in a Posttranscriptional Iron Regulatory Mechanism

    Science.gov (United States)

    Figueroa-Angulo, Elisa E.; Calla-Choque, Jaeson S.; Mancilla-Olea, Maria Inocente; Arroyo, Rossana

    2015-01-01

    Iron homeostasis is highly regulated in vertebrates through a regulatory system mediated by RNA-protein interactions between the iron regulatory proteins (IRPs) that interact with an iron responsive element (IRE) located in certain mRNAs, dubbed the IRE-IRP regulatory system. Trichomonas vaginalis, the causal agent of trichomoniasis, presents high iron dependency to regulate its growth, metabolism, and virulence properties. Although T. vaginalis lacks IRPs or proteins with aconitase activity, possesses gene expression mechanisms of iron regulation at the transcriptional and posttranscriptional levels. However, only one gene with iron regulation at the transcriptional level has been described. Recently, our research group described an iron posttranscriptional regulatory mechanism in the T. vaginalis tvcp4 and tvcp12 cysteine proteinase mRNAs. The tvcp4 and tvcp12 mRNAs have a stem-loop structure in the 5'-coding region or in the 3'-UTR, respectively that interacts with T. vaginalis multifunctional proteins HSP70, α-Actinin, and Actin under iron starvation condition, causing translation inhibition or mRNA stabilization similar to the previously characterized IRE-IRP system in eukaryotes. Herein, we summarize recent progress and shed some light on atypical RNA-binding proteins that may participate in the iron posttranscriptional regulation in T. vaginalis. PMID:26703754

  20. Rapid kinetics of iron responsive element (IRE) RNA/iron regulatory protein 1 and IRE-RNA/eIF4F complexes respond differently to metal ions.

    Science.gov (United States)

    Khan, Mateen A; Ma, Jia; Walden, William E; Merrick, William C; Theil, Elizabeth C; Goss, Dixie J

    2014-06-01

    Metal ion binding was previously shown to destabilize IRE-RNA/IRP1 equilibria and enhanced IRE-RNA/eIF4F equilibria. In order to understand the relative importance of kinetics and stability, we now report rapid rates of protein/RNA complex assembly and dissociation for two IRE-RNAs with IRP1, and quantitatively different metal ion response kinetics that coincide with the different iron responses in vivo. kon, for FRT IRE-RNA binding to IRP1 was eight times faster than ACO2 IRE-RNA. Mn(2+) decreased kon and increased koff for IRP1 binding to both FRT and ACO2 IRE-RNA, with a larger effect for FRT IRE-RNA. In order to further understand IRE-mRNA regulation in terms of kinetics and stability, eIF4F kinetics with FRT IRE-RNA were determined. kon for eIF4F binding to FRT IRE-RNA in the absence of metal ions was 5-times slower than the IRP1 binding to FRT IRE-RNA. Mn(2+) increased the association rate for eIF4F binding to FRT IRE-RNA, so that at 50 µM Mn(2+) eIF4F bound more than 3-times faster than IRP1. IRP1/IRE-RNA complex has a much shorter life-time than the eIF4F/IRE-RNA complex, which suggests that both rate of assembly and stability of the complexes are important, and that allows this regulatory system to respond rapidly to change in cellular iron. © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

  1. Involvement of the iron regulatory protein from Eisenia andrei earthworms in the regulation of cellular iron homeostasis.

    Directory of Open Access Journals (Sweden)

    Petra Procházková

    Full Text Available Iron homeostasis in cells is regulated by iron regulatory proteins (IRPs that exist in different organisms. IRPs are cytosolic proteins that bind to iron-responsive elements (IREs of the 5'- or 3'-untranslated regions (UTR of mRNAs that encode many proteins involved in iron metabolism. In this study, we have cloned and described a new regulatory protein belonging to the family of IRPs from the earthworm Eisenia andrei (EaIRP. The earthworm IRE site in 5'-UTR of ferritin mRNA most likely folds into a secondary structure that differs from the conventional IRE structures of ferritin due to the absence of a typically unpaired cytosine that participates in protein binding. Prepared recombinant EaIRP and proteins from mammalian liver extracts are able to bind both mammalian and Eisenia IRE structures of ferritin mRNA, although the affinity of the rEaIRP/Eisenia IRE structure is rather low. This result suggests the possible contribution of a conventional IRE structure. When IRP is supplemented with a Fe-S cluster, it can function as a cytosolic aconitase. Cellular cytosolic and mitochondrial fractions, as well as recombinant EaIRP, exhibit aconitase activity that can be abolished by the action of oxygen radicals. The highest expression of EaIRP was detected in parts of the digestive tract. We can assume that earthworms may possess an IRE/IRP regulatory network as a potential mechanism for maintaining cellular iron homeostasis, although the aconitase function of EaIRP is most likely more relevant.

  2. Involvement of the Iron Regulatory Protein from Eisenia andrei Earthworms in the Regulation of Cellular Iron Homeostasis

    Science.gov (United States)

    Procházková, Petra; Škanta, František; Roubalová, Radka; Šilerová, Marcela; Dvořák, Jiří; Bilej, Martin

    2014-01-01

    Iron homeostasis in cells is regulated by iron regulatory proteins (IRPs) that exist in different organisms. IRPs are cytosolic proteins that bind to iron-responsive elements (IREs) of the 5′- or 3′-untranslated regions (UTR) of mRNAs that encode many proteins involved in iron metabolism. In this study, we have cloned and described a new regulatory protein belonging to the family of IRPs from the earthworm Eisenia andrei (EaIRP). The earthworm IRE site in 5′-UTR of ferritin mRNA most likely folds into a secondary structure that differs from the conventional IRE structures of ferritin due to the absence of a typically unpaired cytosine that participates in protein binding. Prepared recombinant EaIRP and proteins from mammalian liver extracts are able to bind both mammalian and Eisenia IRE structures of ferritin mRNA, although the affinity of the rEaIRP/Eisenia IRE structure is rather low. This result suggests the possible contribution of a conventional IRE structure. When IRP is supplemented with a Fe-S cluster, it can function as a cytosolic aconitase. Cellular cytosolic and mitochondrial fractions, as well as recombinant EaIRP, exhibit aconitase activity that can be abolished by the action of oxygen radicals. The highest expression of EaIRP was detected in parts of the digestive tract. We can assume that earthworms may possess an IRE/IRP regulatory network as a potential mechanism for maintaining cellular iron homeostasis, although the aconitase function of EaIRP is most likely more relevant. PMID:25279857

  3. HO-1-mediated macroautophagy: a mechanism for unregulated iron deposition in aging and degenerating neural tissues.

    Science.gov (United States)

    Zukor, Hillel; Song, Wei; Liberman, Adrienne; Mui, Jeannie; Vali, Hojatollah; Fillebeen, Carine; Pantopoulos, Kostas; Wu, Ting-Di; Guerquin-Kern, Jean-Luc; Schipper, Hyman M

    2009-05-01

    Oxidative stress, deposition of non-transferrin iron, and mitochondrial insufficiency occur in the brains of patients with Alzheimer disease (AD) and Parkinson disease (PD). We previously demonstrated that heme oxygenase-1 (HO-1) is up-regulated in AD and PD brain and promotes the accumulation of non-transferrin iron in astroglial mitochondria. Herein, dynamic secondary ion mass spectrometry (SIMS) and other techniques were employed to ascertain (i) the impact of HO-1 over-expression on astroglial mitochondrial morphology in vitro, (ii) the topography of aberrant iron sequestration in astrocytes over-expressing HO-1, and (iii) the role of iron regulatory proteins (IRP) in HO-1-mediated iron deposition. Astroglial hHO-1 over-expression induced cytoplasmic vacuolation, mitochondrial membrane damage, and macroautophagy. HO-1 promoted trapping of redox-active iron and sulfur within many cytopathological profiles without impacting ferroportin, transferrin receptor, ferritin, and IRP2 protein levels or IRP1 activity. Thus, HO-1 activity promotes mitochondrial macroautophagy and sequestration of redox-active iron in astroglia independently of classical iron mobilization pathways. Glial HO-1 may be a rational therapeutic target in AD, PD, and other human CNS conditions characterized by the unregulated deposition of brain iron.

  4. Repetitive display system of line profiles for Doppler broadening measurement

    International Nuclear Information System (INIS)

    Mohri, A.; Narihara, K.; Haba, K.

    1982-10-01

    Line profiles of impurities in visible and ultraviolet regions are repetitively displayed on a CRT with an interval of 250 mu s or 500 mu s, using a system composed of a Czerny-Turner monochromator with 1 m F.L., a self-resonant optical scanner, a photomultiplier shielded against hard X-rays and electronic circuits. The profile resolution is 0.035 nm FWHM. This system can be used in the environment of strong hard X-rays. (author)

  5. Role of nitric oxide in cellular iron metabolism.

    Science.gov (United States)

    Kim, Sangwon; Ponka, Prem

    2003-03-01

    Iron regulatory proteins (IRP1 and IRP2) control the synthesis of transferrin receptors (TfR) and ferritin by binding to iron-responsive elements (IREs) which are located in the 3' untranslated region (UTR) and the 5' UTR of their respective mRNAs. Cellular iron levels affect binding of IRPs to IREs and consequently expression of TfR and ferritin. Moreover, NO*, a redox species of nitric oxide that interacts primarily with iron, can activate IRP1 RNA-binding activity resulting in an increase in TfR mRNA levels. We have shown that treatment of RAW 264.7 cells (a murine macrophage cell line) with NO+ (nitrosonium ion, which causes S-nitrosylation of thiol groups) resulted in a rapid decrease in RNA-binding of IRP2, followed by IRP2 degradation, and these changes were associated with a decrease in TfR mRNA levels. Moreover, we demonstrated that stimulation of RAW 264.7 cells with lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma) increased IRP1 binding activity, whereas RNA-binding of IRP2 decreased and was followed by a degradation of this protein. Furthermore, the decrease of IRP2 binding/protein levels was associated with a decrease in TfR mRNA levels in LPS/IFN-gamma-treated cells, and these changes were prevented by inhibitors of inducible nitric oxide synthase. These results suggest that NO+-mediated degradation of IRP2 plays a major role in iron metabolism during inflammation.

  6. Beam profile diagnostics system for SDUV-FEL

    International Nuclear Information System (INIS)

    Xu Yichao; Han Lifeng; Chen Yongzhong

    2010-01-01

    A new beam profile diagnostics system for Shanghai Deep Ultraviolet Free Electron Laser (SDUV-FEL) has been developed based on industrial Ethernet, with good versatility and scalability. The system includes three major subsystems for image acquisition,pneumatic control and stepper motor control, respectively. Virtual instrument technology is adopted to drive the devices, and to develop the measurement software. In this paper,we describe the system structure, and its hardware and software design. The results of system commissioning are given as well. As an important diagnostic tool and data acquisition method, the system has been successfully applied to the measurement and control of the SDUV-FEL.(authors)

  7. Implementation of Bluetooth serial port based profiles in embedded systems

    Science.gov (United States)

    Liu, Guanglei; Qiu, Zhengding; Wang, Quanping; Gao, Qiang

    2001-10-01

    Bluetooth is a new short-range wireless communication technology developing rapidly in recent years. Bluetooth software architecture consists of stack and profiles. Serial Port Profile (SPP) is an underlying profile that emulates RS232 serial cable connections between two peer devices. Based on SPP, Dial-up Networking (DUN) Profile establishes PPP connection with remote dial-up server, Fax Profile realizes document facsimile function and LAN Access Profile (LAP) provides local area network access service. When it comes to their implementation in embedded systems, there are several challenges such as memory consumption, code efficiency, code reliability, and code portability onto different OS and hardware platforms to be attacked. In this paper, we propose integrated software architecture after discussing the great similarities shared among the three SPP based profiles. Then implementation of the architecture is given, in which OS-dependent and OS-independent parts are clearly separated. Profile interfaces with stack and OS are specified respectively so that the three profiles as a whole can be ported onto various software and hardware platforms easily. As a result, policy of transplanting our implementation onto different platforms is addressed at the end of the paper.

  8. Seabed resident event driven profiling system (SREP). Concept, design and tests

    Digital Repository Service at National Institute of Oceanography (India)

    Mascarenhas, A.A.M.Q.; Afzulpurkar, S.; Maurya, P.K.; Fernandes, L.; Madhan, R.; Desa, E.S.; Dabolkar, N.A.; Navelkar, G.S.; Naik, L.; Shetye, V.G.; Shetty, N.B.; Prabhudesai, S.P.; Nagvekar, S.; Vimalakumari, D.

    The seabed resident event driven profiling system (SREP) described here offers a novel, optimized approach to profiling in coastal waters from seabed to sea surface during the rough seas encountered in the southwest monsoon season (June...

  9. CAMEX-3 AIRBORNE VERTICAL ATMOSPHERE PROFILING SYSTEM (AVAPS) V1

    Data.gov (United States)

    National Aeronautics and Space Administration — The CAMEX-3 DC-8 Airborne Vertical Atmosphere Profiling System (AVAPS) uses dropwindsonde and Global Positioning System (GPS) receivers to measure the atmospheric...

  10. Nitric oxide-mediated modulation of iron regulatory proteins: implication for cellular iron homeostasis.

    Science.gov (United States)

    Kim, Sangwon; Ponka, Prem

    2002-01-01

    Iron regulatory proteins (IRP1 and IRP2) control the synthesis of transferrin receptors (TfR) and ferritin by binding to iron-responsive elements (IREs) that are located in the 3' untranslated region (UTR) and the 5' UTR of their respective mRNAs. Cellular iron levels affect binding of IRPs to IREs and consequently expression of TfR and ferritin. Moreover, NO(.), a redox species of nitric oxide that interacts primarily with iron, can activate IRP1 RNA-binding activity resulting in an increase in TfR mRNA levels and a decrease in ferritin synthesis. We have shown that treatment of RAW 264.7 cells (a murine macrophage cell line) with NO(+) (nitrosonium ion, which causes S-nitrosylation of thiol groups) resulted in a rapid decrease in RNA-binding of IRP2, followed by IRP2 degradation, and these changes were associated with a decrease in TfR mRNA levels and a dramatic increase in ferritin synthesis. Moreover, we demonstrated that stimulation of RAW 264.7 cells with lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma) increased IRP1 binding activity, whereas RNA-binding of IRP2 decreased and was followed by a degradation of this protein. Furthermore, the decrease of IRP2 binding/protein levels was associated with a decrease in TfR mRNA levels and an increase in ferritin synthesis in LPS/IFN-gamma-treated cells, and these changes were prevented by inhibitors of inducible nitric oxide synthase. These results suggest that NO(+)-mediated degradation of IRP2 plays a major role in iron metabolism during inflammation.

  11. Renewable energy and integrated resource planning

    International Nuclear Information System (INIS)

    Porter, K.L.

    1992-01-01

    Integrated resource planning, or IRP, is a new means of comparing resource choices for electric and gas utilities. Since its inception in 1986, at least 15 states have implemented IRP, and more are considering adopting IRP or have limited IRP processes in place. Some of the characteristics of IRP, such as increased public participation and an expanded analysis of the costs and benefits of energy resources, can contribute to addressing some of the technical and market barriers that hinder the increased deployment of renewable energy technologies. This paper looks at the status of some of these issues

  12. Mammalian iron metabolism and its control by iron regulatory proteins☆

    Science.gov (United States)

    Anderson, Cole P.; Shen, Lacy; Eisenstein, Richard S.; Leibold, Elizabeth A.

    2013-01-01

    Cellular iron homeostasis is maintained by iron regulatory proteins 1 and 2 (IRP1 and IRP2). IRPs bind to iron-responsive elements (IREs) located in the untranslated regions of mRNAs encoding protein involved in iron uptake, storage, utilization and export. Over the past decade, significant progress has been made in understanding how IRPs are regulated by iron-dependent and iron-independent mechanisms and the pathological consequences of IRP2 deficiency in mice. The identification of novel IREs involved in diverse cellular pathways has revealed that the IRP–IRE network extends to processes other than iron homeostasis. A mechanistic understanding of IRP regulation will likely yield important insights into the basis of disorders of iron metabolism. This article is part of a Special Issue entitled: Cell Biology of Metals. PMID:22610083

  13. A UML profile for code generation of component based distributed systems

    International Nuclear Information System (INIS)

    Chiozzi, G.; Karban, R.; Andolfato, L.; Tejeda, A.

    2012-01-01

    A consistent and unambiguous implementation of code generation (model to text transformation) from UML (must rely on a well defined UML (Unified Modelling Language) profile, customizing UML for a particular application domain. Such a profile must have a solid foundation in a formally correct ontology, formalizing the concepts and their relations in the specific domain, in order to avoid a maze or set of wildly created stereotypes. The paper describes a generic profile for the code generation of component based distributed systems for control applications, the process to distill the ontology and define the profile, and the strategy followed to implement the code generator. The main steps that take place iteratively include: defining the terms and relations with an ontology, mapping the ontology to the appropriate UML meta-classes, testing the profile by creating modelling examples, and generating the code. This has allowed us to work on the modelling of E-ELT (European Extremely Large Telescope) control system and instrumentation without knowing what infrastructure will be finally used

  14. Application of MySQL in instantaneous profile gauge system

    International Nuclear Information System (INIS)

    Guo Xiaojing; Miao Jichen; Wu Zhifang

    2011-01-01

    As equipment in the hot rolling plate plant for online measurement of strip steel, the instantaneous profile gauge is used to measure instant crown of hot rolling strips and feed back the crown to the rolling mill to adjust strip profile. During the measurement, a large amount of data need to be stored reasonably for query, display, computation and other processing, while a database management software can make it happen. Based on such features of MySQL as small size, fast speed, low cost and open source codes, a database function was implemented in the instantaneous profile gauge for data storage, query and maintenance, by applying MySQL database management system and integrating with the control interface. (authors)

  15. Internet-based Profiler system as integrative framework to support translational research.

    Science.gov (United States)

    Kim, Robert; Demichelis, Francesca; Tang, Jeffery; Riva, Alberto; Shen, Ronglai; Gibbs, Doug F; Mahavishno, Vasudeva; Chinnaiyan, Arul M; Rubin, Mark A

    2005-12-19

    Translational research requires taking basic science observations and developing them into clinically useful tests and therapeutics. We have developed a process to develop molecular biomarkers for diagnosis and prognosis by integrating tissue microarray (TMA) technology and an internet-database tool, Profiler. TMA technology allows investigators to study hundreds of patient samples on a single glass slide resulting in the conservation of tissue and the reduction in inter-experimental variability. The Profiler system allows investigator to reliably track, store, and evaluate TMA experiments. Here within we describe the process that has evolved through an empirical basis over the past 5 years at two academic institutions. The generic design of this system makes it compatible with multiple organ system (e.g., prostate, breast, lung, renal, and hematopoietic system,). Studies and folders are restricted to authorized users as required. Over the past 5 years, investigators at 2 academic institutions have scanned 656 TMA experiments and collected 63,311 digital images of these tissue samples. 68 pathologists from 12 major user groups have accessed the system. Two groups directly link clinical data from over 500 patients for immediate access and the remaining groups choose to maintain clinical and pathology data on separate systems. Profiler currently has 170 K data points such as staining intensity, tumor grade, and nuclear size. Due to the relational database structure, analysis can be easily performed on single or multiple TMA experimental results. The TMA module of Profiler can maintain images acquired from multiple systems. We have developed a robust process to develop molecular biomarkers using TMA technology and an internet-based database system to track all steps of this process. This system is extendable to other types of molecular data as separate modules and is freely available to academic institutions for licensing.

  16. A New Profile Learning Model for Recommendation System based on Machine Learning Technique

    Directory of Open Access Journals (Sweden)

    Shereen H. Ali

    2016-03-01

    Full Text Available Recommender systems (RSs have been used to successfully address the information overload problem by providing personalized and targeted recommendations to the end users. RSs are software tools and techniques providing suggestions for items to be of use to a user, hence, they typically apply techniques and methodologies from Data Mining. The main contribution of this paper is to introduce a new user profile learning model to promote the recommendation accuracy of vertical recommendation systems. The proposed profile learning model employs the vertical classifier that has been used in multi classification module of the Intelligent Adaptive Vertical Recommendation (IAVR system to discover the user’s area of interest, and then build the user’s profile accordingly. Experimental results have proven the effectiveness of the proposed profile learning model, which accordingly will promote the recommendation accuracy.

  17. Transcriptional profiling of Actinobacillus pleuropneumoniae during the acute phase of a natural infection in pigs

    Directory of Open Access Journals (Sweden)

    Harel Josée

    2010-02-01

    Full Text Available Abstract Background Actinobacillus pleuropneumoniae is the etiological agent of porcine pleuropneumonia, a respiratory disease which causes great economic losses worldwide. Many virulence factors are involved in the pathogenesis, namely capsular polysaccharides, RTX toxins, LPS and many iron acquisition systems. In order to identify genes that are expressed in vivo during a natural infection, we undertook transcript profiling experiments with an A. pleuropneumoniae DNA microarray, after recovery of bacterial mRNAs from serotype 5b-infected porcine lungs. AppChip2 contains 2033 PCR amplicons based on the genomic sequence of App serotype 5b strain L20, representing more than 95% of ORFs greater than 160 bp in length. Results Transcriptional profiling of A. pleuropneumoniae recovered from the lung of a pig suffering from a natural infection or following growth of the bacterial isolate in BHI medium was performed. An RNA extraction protocol combining beadbeating and hot-acid-phenol was developed in order to maximize bacterial mRNA yields and quality following total RNA extraction from lung lesions. Nearly all A. pleuropneumoniae transcripts could be detected on our microarrays, and 150 genes were deemed differentially expressed in vivo during the acute phase of the infection. Our results indicate that, for example, gene apxIVA from an operon coding for RTX toxin ApxIV is highly up-regulated in vivo, and that two genes from the operon coding for type IV fimbriae (APL_0878 and APL_0879 were also up-regulated. These transcriptional profiling data, combined with previous comparative genomic hybridizations performed by our group, revealed that 66 out of the 72 up-regulated genes are conserved amongst all serotypes and that 3 of them code for products that are predicted outer membrane proteins (genes irp and APL_0959, predicted to code for a TonB-dependent receptor and a filamentous hemagglutinin/adhesin respectively or lipoproteins (gene APL_0920. Only 4

  18. Interim Measures Work Plan Expanded Bioventing System SWMU 55 (IRP Site FT-03)

    National Research Council Canada - National Science Library

    1997-01-01

    This interim measures work plan (IMWP) presents the scope for an expanded bioventing system to conduct in situ treatment of the remaining fuel-contaminated soils at solid waste management unit (SWMU...

  19. Binocular vision, the optic chiasm, and their associations with vertebrate motor behavior

    Directory of Open Access Journals (Sweden)

    Matz Lennart Larsson

    2015-07-01

    Full Text Available Ipsilateral retinal projections (IRP in the optic chiasm (OC vary considerably. Most animal groups possess laterally situated eyes and no or few IRP, but, e.g. cats and primates have frontal eyes and high proportions of IRP. The traditional hypothesis that bifocal vision developed to enable predation or to increase perception in restricted light conditions applies mainly to mammals. The eye-forelimb (EF hypothesis presented here suggests that the reception of visual feedback of limb movements in the limb steering cerebral hemisphere was the fundamental mechanism behind the OC evolution. In other words, that evolutionary change in the OC was necessary to preserve hemispheric autonomy. In the majority of vertebrates, motor processing, tactile, proprioceptive, and visual information involved in steering the hand (limb, paw, fin is primarily received only in the contralateral hemisphere, while multisensory information from the ipsilateral limb is minimal. Since the involved motor nuclei, somatosensory areas, and vision neurons are situated in same hemisphere, the neuronal pathways involved will be relatively short, optimizing the size of the brain. That would not have been possible without, evolutionary modifications of IRP. Multiple axon-guidance genes, which determine whether axons will cross the midline or not, have shaped the OC anatomy. Evolutionary change in the OC seems to be key to preserving hemispheric autonomy when the body and eye evolve to fit new ecological niches. The EF hypothesis may explain the low proportion of IRP in birds, reptiles, and most fishes; the relatively high proportions of IRP in limbless vertebrates; high proportions of IRP in arboreal, in contrast to ground-dwelling, marsupials; the lack of IRP in dolphins; abundant IRP in primates and most predatory mammals, and why IRP emanate exclusively from the temporal retina. The EF hypothesis seams applicable to vertebrates in general and hence more parsimonious than

  20. Exact boundary controllability of nodal profile for quasilinear hyperbolic systems

    CERN Document Server

    Li, Tatsien; Gu, Qilong

    2016-01-01

    This book provides a comprehensive overview of the exact boundary controllability of nodal profile, a new kind of exact boundary controllability stimulated by some practical applications. This kind of controllability is useful in practice as it does not require any precisely given final state to be attained at a suitable time t=T by means of boundary controls, instead it requires the state to exactly fit any given demand (profile) on one or more nodes after a suitable time t=T by means of boundary controls. In this book we present a general discussion of this kind of controllability for general 1-D first order quasilinear hyperbolic systems and for general 1-D quasilinear wave equations on an interval as well as on a tree-like network using a modular-structure construtive method, suggested in LI Tatsien's monograph "Controllability and Observability for Quasilinear Hyperbolic Systems"(2010), and we establish a complete theory on the local exact boundary controllability of nodal profile for 1-D quasilinear hyp...

  1. A paper recommender system based on user's profile in big data ...

    African Journals Online (AJOL)

    These systems present a personalized proposal to users who seek to find a special kind of relevant data or their priorities through the big number of data. Recommendersystem based on personalization uses the user profile and in view of the fact that the user profile encompass information pertaining to the user priorities; ...

  2. Profiles of the Hα line by means of the analogical television system

    International Nuclear Information System (INIS)

    Andrillat, Y.; Fehrenbach, Ch.

    1981-01-01

    High resolution profiles of the Hα line are derived for about thirty Be stars and several bright stars by means of the analogical television system. The profiles obtained with this method fairly agree with the theoretical ones (α Lyrae). (Auth.)

  3. Advantages and Pitfalls of Mass Spectrometry Based Metabolome Profiling in Systems Biology

    Directory of Open Access Journals (Sweden)

    Ina Aretz

    2016-04-01

    Full Text Available Mass spectrometry-based metabolome profiling became the method of choice in systems biology approaches and aims to enhance biological understanding of complex biological systems. Genomics, transcriptomics, and proteomics are well established technologies and are commonly used by many scientists. In comparison, metabolomics is an emerging field and has not reached such high-throughput, routine and coverage than other omics technologies. Nevertheless, substantial improvements were achieved during the last years. Integrated data derived from multi-omics approaches will provide a deeper understanding of entire biological systems. Metabolome profiling is mainly hampered by its diversity, variation of metabolite concentration by several orders of magnitude and biological data interpretation. Thus, multiple approaches are required to cover most of the metabolites. No software tool is capable of comprehensively translating all the data into a biologically meaningful context yet. In this review, we discuss the advantages of metabolome profiling and main obstacles limiting progress in systems biology.

  4. Advantages and Pitfalls of Mass Spectrometry Based Metabolome Profiling in Systems Biology.

    Science.gov (United States)

    Aretz, Ina; Meierhofer, David

    2016-04-27

    Mass spectrometry-based metabolome profiling became the method of choice in systems biology approaches and aims to enhance biological understanding of complex biological systems. Genomics, transcriptomics, and proteomics are well established technologies and are commonly used by many scientists. In comparison, metabolomics is an emerging field and has not reached such high-throughput, routine and coverage than other omics technologies. Nevertheless, substantial improvements were achieved during the last years. Integrated data derived from multi-omics approaches will provide a deeper understanding of entire biological systems. Metabolome profiling is mainly hampered by its diversity, variation of metabolite concentration by several orders of magnitude and biological data interpretation. Thus, multiple approaches are required to cover most of the metabolites. No software tool is capable of comprehensively translating all the data into a biologically meaningful context yet. In this review, we discuss the advantages of metabolome profiling and main obstacles limiting progress in systems biology.

  5. Heme metabolism as an integral part of iron homeostasis

    Directory of Open Access Journals (Sweden)

    Paweł Lipiński

    2014-01-01

    Full Text Available Heme, a ferrous iron protoporphyrin IX complex, is employed as a prosthetic group in a number of diverse heme proteins that participate in important cellular and systemic physiological processes. Provision of an adequate amount of iron for heme biosynthesis is one of the elemental hallmarks of intracellular iron homeostasis. In the cell the bioavailability of iron for the two main iron biological pathways – heme synthesis and the biogenesis of iron-sulfur clusters ([Fe-S] – is mainly regulated by the IRP/IRE posttranscriptional system. The biogenesis of [Fe-S] centers is crucial for heme synthesis because these co-factors determine the activity of IRP1 and that of ferrochelatase, an enzyme responsible for the insertion of an iron into protoporphyrin IX to produce heme. On the other hand, delivery of iron for heme and hemoglobin synthesis in erythroblasts, precursors of erythrocytes in bone marrow, is an indispensable element of body iron homeostasis. This process relies on the recovery of iron from senescent red blood cells through the enzymatic degradation of heme molecules and recycling of iron to the circulation. Molecular coordination of these processes involves the activity of heme oxygenase 1, IRP1 and IRP2 as well as the functioning of the hepcidin-ferroportin regulatory axis. Recent studies show in mammals the existence of an expanded system of proteins involved in the transport of intact heme molecules at the cellular and systemic levels. The biological role of this system is of particular importance when the concentration of free heme reaches a toxic level in the body (intravascular hemolysis as well as locally in cells having intensive heme metabolism such as erythroblasts and macrophages.

  6. [Heme metabolism as an integral part of iron homeostasis].

    Science.gov (United States)

    Lipiński, Paweł; Starzyński, Rafał R; Styś, Agnieszka; Gajowiak, Anna; Staroń, Robert

    2014-01-02

    Heme, a ferrous iron protoporphyrin IX complex, is employed as a prosthetic group in a number of diverse heme proteins that participate in important cellular and systemic physiological processes. Provision of an adequate amount of iron for heme biosynthesis is one of the elemental hallmarks of intracellular iron homeostasis. In the cell the bioavailability of iron for the two main iron biological pathways--heme synthesis and the biogenesis of iron-sulfur clusters ([Fe-S])--is mainly regulated by the IRP/IRE posttranscriptional system. The biogenesis of [Fe-S] centers is crucial for heme synthesis because these co-factors determine the activity of IRP1 and that of ferrochelatase, an enzyme responsible for the insertion of an iron into protoporphyrin IX to produce heme. On the other hand, delivery of iron for heme and hemoglobin synthesis in erythroblasts, precursors of erythrocytes in bone marrow, is an indispensable element of body iron homeostasis. This process relies on the recovery of iron from senescent red blood cells through the enzymatic degradation of heme molecules and recycling of iron to the circulation. Molecular coordination of these processes involves the activity of heme oxygenase 1, IRP1 and IRP2 as well as the functioning of the hepcidin-ferroportin regulatory axis. Recent studies show in mammals the existence of an expanded system of proteins involved in the transport of intact heme molecules at the cellular and systemic levels. The biological role of this system is of particular importance when the concentration of free heme reaches a toxic level in the body (intravascular hemolysis) as well as locally in cells having intensive heme metabolism such as erythroblasts and macrophages.

  7. Towards Malaysian LADM Country Profile for 2D and 3D Cadastral Registration System

    OpenAIRE

    Zulkifli, N.A.; Abdul Rahman, A.; Jamil, H.; Teng, C.H.; Tan, L.C.; Looi, K.S.; Chan, K.L.; Van Oosterom, P.J.M.

    2014-01-01

    This paper proposes a comprehensive Land Administration Domain Model (LADM, ISO 2012) country profile for 2D and 3D cadastral registration system for Malaysia. The proposed Malaysian country profile is partly based on the existing spatial (including survey) and administrative registration systems, and partly based on new developments inspired by the LADM standard. Within the country profile, an attempt is made to cover all Malaysian land administration related information, which are maintaine...

  8. Towards Malaysian LADM Country Profile for 2D and 3D Cadastral Registration System

    NARCIS (Netherlands)

    Zulkifli, N.A.; Abdul Rahman, A.; Jamil, H.; Teng, C.H.; Tan, L.C.; Looi, K.S.; Chan, K.L.; Van Oosterom, P.J.M.

    2014-01-01

    This paper proposes a comprehensive Land Administration Domain Model (LADM, ISO 2012) country profile for 2D and 3D cadastral registration system for Malaysia. The proposed Malaysian country profile is partly based on the existing spatial (including survey) and administrative registration systems,

  9. IFMIF-LIPAc Beam Diagnostics. Profiling and Loss Monitoring Systems

    International Nuclear Information System (INIS)

    Egberts, J.

    2012-01-01

    The IFMIF accelerator will accelerate two 125 mA continuous wave (cw) deuteron beams up to 40 MeV and blasts them onto a liquid lithium target to release neutrons. The very high beam power of 10 MW pose unprecedented challenges for the accelerator development. Therefore, it was decided to build a prototype accelerator, the Linear IFMIF Prototype Accelerator (LIPAc), which has the very same beam characteristic, but is limited to 9 MeV only. In the frame of this thesis, diagnostics devices for IFMIF and LIPAc have been developed. The diagnostics devices consist of beam loss monitors and interceptive as well as non-interceptive profile monitors. For the beam loss monitoring system, ionization chambers and diamond detectors have been tested and calibrated for neutron and γ radiation in the energy range expected at LIPAc. During these tests, for the first time, diamond detectors were successfully operated at cryogenic temperatures. For the interceptive profilers, thermal simulations were performed to ensure safe operation. For the non-interceptive profiler, Ionization Profile Monitors (IPMs) were developed. A prototype has been built and tested, and based on the findings, the final IPMs were designed and built. To overcome the space charge of accelerator beam, a software algorithm was written to reconstruct the actual beam profile. (author) [fr

  10. World Energy Data System (WENDS). Volume VI. International agreement profiles

    Energy Technology Data Exchange (ETDEWEB)

    None

    1979-06-01

    The World Energy Data System contains organized data on those countries and international organizations that may have critical impact on world energy. The international agreement profiles in WENDS are all energy-related and are organized by energy technology. These are: coal; conservation; fusion; geothermal; nuclear fission; oil, gas, and shale; solar, wind, and ocean thermal; and other (cooperation in electrical power equipment acquisition, energy, energy research, etc.). The agreement profiles are accessible by energy technology and alphabetically by country.

  11. The Beam Profile Monitoring System for the CERN IRRAD Proton Facility

    CERN Document Server

    Ravotti, F; Glaser, M; Matli, E; Pezzullo, G; Gan, K K; Kagan, H; Smith, S; Warner, J D

    2017-01-01

    GeV/c proton beam is used. During beam steering and irradiation, the intensity and the transverse profile of the proton beam are monitored online with custom-made Beam Profile Monitor (BPM) devices. In this work, we present the design and the architecture of the IRRAD BPM system, some results on its performance with the proton beam, as well as its planned grades.

  12. Image processing and computer controls for video profile diagnostic system in the ground test accelerator (GTA)

    International Nuclear Information System (INIS)

    Wright, R.; Zander, M.; Brown, S.; Sandoval, D.; Gilpatrick, D.; Gibson, H.

    1992-01-01

    This paper describes the application of video image processing to beam profile measurements on the Ground Test Accelerator (GTA). A diagnostic was needed to measure beam profiles in the intermediate matching section (IMS) between the radio-frequency quadrupole (RFQ) and the drift tube linac (DTL). Beam profiles are measured by injecting puffs of gas into the beam. The light emitted from the beam-gas interaction is captured and processed by a video image processing system, generating the beam profile data. A general purpose, modular and flexible video image processing system, imagetool, was used for the GTA image profile measurement. The development of both software and hardware for imagetool and its integration with the GTA control system (GTACS) is discussed. The software includes specialized algorithms for analyzing data and calibrating the system. The underlying design philosophy of imagetool was tested by the experience of building and using the system, pointing the way for future improvements. (Author) (3 figs., 4 refs.)

  13. Power profiling of Cholesky and QR factorizations on distributed memory systems

    KAUST Repository

    Bosilca, George; Ltaief, Hatem; Dongarra, Jack

    2012-01-01

    with a dynamic distributed scheduler (DAGuE) to leverage distributed memory systems. We present performance results (Gflop/s) as well as the power profile (Watts) of two common dense factorizations needed to solve linear systems of equations, namely

  14. Deletion of Iron Regulatory Protein 1 Causes Polycythemia and Pulmonary Hypertension in Mice through Translational De-repression of HIF2α

    Science.gov (United States)

    Ghosh, Manik C.; Zhang, De-Liang; Jeong, Suh Young; Kovtunovych, Gennadiy; Ollivierre-Wilson, Hayden; Noguchi, Audrey; Tu, Tiffany; Senecal, Thomas; Robinson, Gabrielle; Crooks, Daniel R.; Tong, Wing-Hang; Ramaswamy, Kavitha; Singh, Anamika; Graham, Brian B.; Tuder, Rubin M.; Yu, Zu-Xi; Eckhaus, Michael; Lee, Jaekwon; Springer, Danielle A.; Rouault, Tracey A.

    2013-01-01

    SUMMARY Iron regulatory proteins 1 and 2 (Irps) post-transcriptionally control the expression of transcripts that contain iron responsive element (IRE) sequences, including ferritin, ferroportin, transferrin receptor and hypoxia inducible factor 2α (HIF2α). We report here that mice with targeted deletion of Irp1 developed pulmonary hypertension and polycythemia that was exacerbated by a low iron diet. Hematocrits increased to 65% in iron-starved mice, and many polycythemic mice died of abdominal hemorrhages. Irp1 deletion enhanced HIF2α protein expression in kidneys of Irp1−/− mice, which led to increased erythropoietin (EPO) expression, polycythemia and concomitant tissue iron deficiency. Increased HIF2α expression in pulmonary endothelial cells induced high expression of endothelin-1, likely contributing to the pulmonary hypertension of Irp1−/− mice. Our results reveal why anemia is an early physiological consequence of iron deficiency, highlight the physiological significance of Irp1 in regulating erythropoiesis and iron distribution, and provide important insights into the molecular pathogenesis of pulmonary hypertension. PMID:23395173

  15. 77 FR 32004 - Guidelines for the Supervisory Review Committee

    Science.gov (United States)

    2012-05-31

    ... and soundness standards. II. IRPS 12-1 IRPS 12-1 amends IRPS 11-1 by removing all references to the... (APA), 5 U.S.C. 553(b)(3)(A) and Sec. 553(b)(3)(B), because these provisions allow an agency to issue... housekeeping measure to remove references to a nonexistent program. The Board finds these reasons are good...

  16. Integrated resource planning for the rational use of energy in Slovenia. Overview of analysis with discussion of the role of WASP

    International Nuclear Information System (INIS)

    Urbancic, A.

    1997-01-01

    Integrated resource planning (IRP) for the regional use of energy in Slovenia is presented in this paper. The main objective of the analysis is the improvement of the overall energy efficiency in Slovenia. Emphasis of the IRP analysis is given on: 1) comparison of demand and supply options and 2) embedding of the planning procedure into a structured analysis procedure to make the planning process more transparent. The Wien Automatic System Planning package (WASP) will be sued in the modeling framework for determining the optimal expansion plan for different demand patterns. This paper provides an overview of the IRP project for Slovenia. The paper consists of three sections. The first section aims at giving an insight on the motivations for the analysis; the second section describes the case studies in structured analysis steps. The role of WASP is discussed in the third part. (author). 9 refs, 2 figs, 1 tab

  17. Integrated resource planning for the rational use of energy in Slovenia. Overview of analysis with discussion of the role of WASP

    Energy Technology Data Exchange (ETDEWEB)

    Urbancic, A [Energy Efficiency Centre, Jozef Stefan Inst., Ljubjana (Slovenia)

    1997-09-01

    Integrated resource planning (IRP) for the regional use of energy in Slovenia is presented in this paper. The main objective of the analysis is the improvement of the overall energy efficiency in Slovenia. Emphasis of the IRP analysis is given on: 1) comparison of demand and supply options and 2) embedding of the planning procedure into a structured analysis procedure to make the planning process more transparent. The Wien Automatic System Planning package (WASP) will be sued in the modeling framework for determining the optimal expansion plan for different demand patterns. This paper provides an overview of the IRP project for Slovenia. The paper consists of three sections. The first section aims at giving an insight on the motivations for the analysis; the second section describes the case studies in structured analysis steps. The role of WASP is discussed in the third part. (author). 9 refs, 2 figs, 1 tab.

  18. Tools and methods for integrated resource planning. Improving energy efficiency and protecting the environment

    International Nuclear Information System (INIS)

    Swisher, J.N.; Martino Jannuzzi, G. de; Redlinger, R.Y.

    1997-01-01

    This book resulted from our recognition of the need to have systematic teaching and training materials on energy efficiency, end-use analysis, demand-side management (DSM) and integrated resource planning (IRP). This book addresses energy efficiency programs and IRP, exploring their application in the electricity sector. We believe that these methods will provide powerful and practical tools for designing efficient and environmentally-sustainable energy supply and demand-side programs to minimize the economic, environmental and other social costs of electricity conversion and use. Moreover, the principles of IRP can be and already are being applied in other areas such as natural gas, water supply, and even transportation and health services. Public authorities can use IRP principles to design programs to encourage end-use efficiency and environmental protection through environmental charges and incentives, non-utility programs, and utility programs applied to the functions remaining in monopoly concessions such as the distribution wires. Competitive supply firms can use IRP principles to satisfy customer needs for efficiency and low prices, to comply with present and future environmental restrictions, and to optimize supply and demand-side investments and returns, particularly at the distribution level, where local-area IRP is now being actively practiced. Finally, in those countries where a strong planning function remains in place, IRP provides a way to integrate end-use efficiency and environmental protection into energy development. (EG) 181 refs

  19. Tools and methods for integrated resource planning. Improving energy efficiency and protecting the environment

    Energy Technology Data Exchange (ETDEWEB)

    Swisher, J N; Martino Jannuzzi, G de; Redlinger, R Y

    1997-11-01

    This book resulted from our recognition of the need to have systematic teaching and training materials on energy efficiency, end-use analysis, demand-side management (DSM) and integrated resource planning (IRP). This book addresses energy efficiency programs and IRP, exploring their application in the electricity sector. We believe that these methods will provide powerful and practical tools for designing efficient and environmentally-sustainable energy supply and demand-side programs to minimize the economic, environmental and other social costs of electricity conversion and use. Moreover, the principles of IRP can be and already are being applied in other areas such as natural gas, water supply, and even transportation and health services. Public authorities can use IRP principles to design programs to encourage end-use efficiency and environmental protection through environmental charges and incentives, non-utility programs, and utility programs applied to the functions remaining in monopoly concessions such as the distribution wires. Competitive supply firms can use IRP principles to satisfy customer needs for efficiency and low prices, to comply with present and future environmental restrictions, and to optimize supply and demand-side investments and returns, particularly at the distribution level, where local-area IRP is now being actively practiced. Finally, in those countries where a strong planning function remains in place, IRP provides a way to integrate end-use efficiency and environmental protection into energy development. (EG) 181 refs.

  20. Profile-IQ: Web-based data query system for local health department infrastructure and activities.

    Science.gov (United States)

    Shah, Gulzar H; Leep, Carolyn J; Alexander, Dayna

    2014-01-01

    To demonstrate the use of National Association of County & City Health Officials' Profile-IQ, a Web-based data query system, and how policy makers, researchers, the general public, and public health professionals can use the system to generate descriptive statistics on local health departments. This article is a descriptive account of an important health informatics tool based on information from the project charter for Profile-IQ and the authors' experience and knowledge in design and use of this query system. Profile-IQ is a Web-based data query system that is based on open-source software: MySQL 5.5, Google Web Toolkit 2.2.0, Apache Commons Math library, Google Chart API, and Tomcat 6.0 Web server deployed on an Amazon EC2 server. It supports dynamic queries of National Profile of Local Health Departments data on local health department finances, workforce, and activities. Profile-IQ's customizable queries provide a variety of statistics not available in published reports and support the growing information needs of users who do not wish to work directly with data files for lack of staff skills or time, or to avoid a data use agreement. Profile-IQ also meets the growing demand of public health practitioners and policy makers for data to support quality improvement, community health assessment, and other processes associated with voluntary public health accreditation. It represents a step forward in the recent health informatics movement of data liberation and use of open source information technology solutions to promote public health.

  1. In vitro steroid profiling system for the evaluation of endocrine disruptors.

    Science.gov (United States)

    Nakano, Yosuke; Yamashita, Toshiyuki; Okuno, Masashi; Fukusaki, Eiichiro; Bamba, Takeshi

    2016-09-01

    Endocrine disruptors (ED) are chemicals that affect various aspects of the endocrine system, often leading to the inhibition of steroidogenesis. Current chemical safety policies that restrict human exposure to such chemicals describe often time-consuming and costly methods for the evaluation of ED effects. We aimed to develop an effective tool for accurate phenotypic chemical toxicology studies. We developed an in vitro ED evaluation system using gas chromatography/mass spectrometry (GC/MS/MS) methods for metabolomic analysis of multi-marker profiles. Accounting for sample preparation and GC/MS/MS conditions, we established a screening method that allowed the simultaneous analysis of 17 steroids with good reproducibility and a linear calibration curve. Moreover, we applied the developed system to H295R human adrenocortical cells exposed to forskolin and prochloraz in accordance with the Organization for Economic Cooperation and Development (OECD) guidelines and observed dose-dependent variations in steroid profiles. While the OECD guidelines include only testosterone and 17β-estradiol, our system enabled a comprehensive and highly sensitive analysis of steroid profile alteration due to ED exposure. The application of our ED evaluation screen could be economical and provide novel insights into the hazards of ED exposure to the endocrine system. Copyright © 2016 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.

  2. Fuel Aging in Storage and Transportation (FAST): Accelerated Characterization and Performance Assessment of the Used Nuclear Fuel Storage System

    International Nuclear Information System (INIS)

    McDeavitt, Sean

    2016-01-01

    This Integrated Research Project (IRP) was established to characterize key limiting phenomena related to the performance of used nuclear fuel (UNF) storage systems. This was an applied engineering project with a specific application in view (i.e., UNF dry storage). The completed tasks made use of a mixture of basic science and engineering methods. The overall objective was to create, or enable the creation of, predictive tools in the form of observation methods, phenomenological models, and databases that will enable the design, installation, and licensing of dry UNF storage systems that will be capable of containing UNF for extended period of time.

  3. Fuel Aging in Storage and Transportation (FAST): Accelerated Characterization and Performance Assessment of the Used Nuclear Fuel Storage System

    Energy Technology Data Exchange (ETDEWEB)

    McDeavitt, Sean [Texas A & M Univ., College Station, TX (United States). Dept. of Nuclear Engineering

    2016-08-02

    This Integrated Research Project (IRP) was established to characterize key limiting phenomena related to the performance of used nuclear fuel (UNF) storage systems. This was an applied engineering project with a specific application in view (i.e., UNF dry storage). The completed tasks made use of a mixture of basic science and engineering methods. The overall objective was to create, or enable the creation of, predictive tools in the form of observation methods, phenomenological models, and databases that will enable the design, installation, and licensing of dry UNF storage systems that will be capable of containing UNF for extended period of time.

  4. A measurement system for vertical seawater profiles close to the air-sea interface

    Science.gov (United States)

    Sims, Richard P.; Schuster, Ute; Watson, Andrew J.; Yang, Ming Xi; Hopkins, Frances E.; Stephens, John; Bell, Thomas G.

    2017-09-01

    This paper describes a near-surface ocean profiler, which has been designed to precisely measure vertical gradients in the top 10 m of the ocean. Variations in the depth of seawater collection are minimized when using the profiler compared to conventional CTD/rosette deployments. The profiler consists of a remotely operated winch mounted on a tethered yet free-floating buoy, which is used to raise and lower a small frame housing sensors and inlet tubing. Seawater at the inlet depth is pumped back to the ship for analysis. The profiler can be used to make continuous vertical profiles or to target a series of discrete depths. The profiler has been successfully deployed during wind speeds up to 10 m s-1 and significant wave heights up to 2 m. We demonstrate the potential of the profiler by presenting measured vertical profiles of the trace gases carbon dioxide and dimethylsulfide. Trace gas measurements use an efficient microporous membrane equilibrator to minimize the system response time. The example profiles show vertical gradients in the upper 5 m for temperature, carbon dioxide and dimethylsulfide of 0.15 °C, 4 µatm and 0.4 nM respectively.

  5. HRR Profiling on Integrated Radar-Communication Systems Using OFDM-PCSF Signals

    Directory of Open Access Journals (Sweden)

    Xuanxuan Tian

    2017-01-01

    Full Text Available In order to improve both the transmission data rate and the range resolution simultaneously in integrated radar-communication (RadCom systems, orthogonal frequency-division multiplexing with phase-coded and stepped-frequency (OFDM-PCSF waveform is proposed. A corresponding high resolution range (HRR profile generation method is also presented. We first perform OFDM-PCSF waveform design by combining the intrapulse phase coding with the interpulse stepped-frequency modulation. We then give the ambiguity function (AF based on the presented waveforms. Then, the synthetic range profile (SRP processing to achieve HRR performance is analyzed. Theoretical analysis and simulation results show that the proposed methods can achieve HRR profiles of the targets and high data rate transmissions, while a relative low computational complexity can be achieved.

  6. Crystallization and preliminary X-ray diffraction analysis of iron regulatory protein 1 in complex with ferritin IRE RNA

    International Nuclear Information System (INIS)

    Selezneva, Anna I.; Cavigiolio, Giorgio; Theil, Elizabeth C.; Walden, William E.; Volz, Karl

    2006-01-01

    The iron regulatory protein IRP1 has been crystallized in a complex with ferritin IRE RNA and a complete data set has been collected to 2.8 Å resolution. Iron regulatory protein 1 (IRP1) is a bifunctional protein with activity as an RNA-binding protein or as a cytoplasmic aconitase. Interconversion of IRP1 between these mutually exclusive states is central to cellular iron regulation and is accomplished through iron-responsive assembly and disassembly of a [4Fe–4S] cluster. When in its apo form, IRP1 binds to iron responsive elements (IREs) found in mRNAs encoding proteins of iron storage and transport and either prevents translation or degradation of the bound mRNA. Excess cellular iron stimulates the assembly of a [4Fe–4S] cluster in IRP1, inhibiting its IRE-binding ability and converting it to an aconitase. The three-dimensional structure of IRP1 in its different active forms will provide details of the interconversion process and clarify the selective recognition of mRNA, Fe–S sites and catalytic activity. To this end, the apo form of IRP1 bound to a ferritin IRE was crystallized. Crystals belong to the monoclinic space group P2 1 , with unit-cell parameters a = 109.6, b = 80.9, c = 142.9 Å, β = 92.0°. Native data sets have been collected from several crystals with resolution extending to 2.8 Å and the structure has been solved by molecular replacement

  7. Measurement system of bubbly flow using ultrasonic velocity profile monitor and video data processing unit

    International Nuclear Information System (INIS)

    Aritomi, Masanori; Zhou, Shirong; Nakajima, Makoto; Takeda, Yasushi; Mori, Michitsugu; Yoshioka, Yuzuru.

    1996-01-01

    The authors have been developing a measurement system for bubbly flow in order to clarify its multi-dimensional flow characteristics and to offer a data base to validate numerical codes for multi-dimensional two-phase flow. In this paper, the measurement system combining an ultrasonic velocity profile monitor with a video data processing unit is proposed, which can measure simultaneously velocity profiles in both gas and liquid phases, a void fraction profile for bubbly flow in a channel, and an average bubble diameter and void fraction. Furthermore, the proposed measurement system is applied to measure flow characteristics of a bubbly countercurrent flow in a vertical rectangular channel to verify its capability. (author)

  8. Initial development of an automated task analysis profiling system

    International Nuclear Information System (INIS)

    Jorgensen, C.C.

    1984-01-01

    A program for automated task analysis is described. Called TAPS (task analysis profiling system), the program accepts normal English prose and outputs skills, knowledges, attitudes, and abilities (SKAAs) along with specific guidance and recommended ability measurement tests for nuclear power plant operators. A new method for defining SKAAs is presented along with a sample program output

  9. Input-profile-based software failure probability quantification for safety signal generation systems

    International Nuclear Information System (INIS)

    Kang, Hyun Gook; Lim, Ho Gon; Lee, Ho Jung; Kim, Man Cheol; Jang, Seung Cheol

    2009-01-01

    The approaches for software failure probability estimation are mainly based on the results of testing. Test cases represent the inputs, which are encountered in an actual use. The test inputs for the safety-critical application such as a reactor protection system (RPS) of a nuclear power plant are the inputs which cause the activation of protective action such as a reactor trip. A digital system treats inputs from instrumentation sensors as discrete digital values by using an analog-to-digital converter. Input profile must be determined in consideration of these characteristics for effective software failure probability quantification. Another important characteristic of software testing is that we do not have to repeat the test for the same input value since the software response is deterministic for each specific digital input. With these considerations, we propose an effective software testing method for quantifying the failure probability. As an example application, the input profile of the digital RPS is developed based on the typical plant data. The proposed method in this study is expected to provide a simple but realistic mean to quantify the software failure probability based on input profile and system dynamics.

  10. Power profiling of Cholesky and QR factorizations on distributed memory systems

    KAUST Repository

    Bosilca, George

    2012-08-30

    This paper presents the power profile of two high performance dense linear algebra libraries on distributed memory systems, ScaLAPACK and DPLASMA. From the algorithmic perspective, their methodologies are opposite. The former is based on block algorithms and relies on multithreaded BLAS and a two-dimensional block cyclic data distribution to achieve high parallel performance. The latter is based on tile algorithms running on top of a tile data layout and uses fine-grained task parallelism combined with a dynamic distributed scheduler (DAGuE) to leverage distributed memory systems. We present performance results (Gflop/s) as well as the power profile (Watts) of two common dense factorizations needed to solve linear systems of equations, namely Cholesky and QR. The reported numbers show that DPLASMA surpasses ScaLAPACK not only in terms of performance (up to 2X speedup) but also in terms of energy efficiency (up to 62 %). © 2012 Springer-Verlag (outside the USA).

  11. Molecular depth profiling of multi-layer systems with cluster ion sources

    Energy Technology Data Exchange (ETDEWEB)

    Cheng, Juan [Department of Chemistry, Penn State University, University Park, PA 16802 (United States); Winograd, Nicholas [Department of Chemistry, Penn State University, University Park, PA 16802 (United States)]. E-mail: nxw@psu.edu

    2006-07-30

    Cluster bombardment of molecular films has created new opportunities for SIMS research. To more quantitatively examine the interaction of cluster beams with organic materials, we have developed a reproducible platform consisting of a well-defined sugar film (trehalose) doped with peptides. Molecular depth profiles have been acquired with these systems using C{sub 60} {sup +} bombardment. In this study, we utilize this platform to determine the feasibility of examining buried interfaces for multi-layer systems. Using C{sub 60} {sup +} at 20 keV, several systems have been tested including Al/trehalose/Si, Al/trehalose/Al/Si, Ag/trehalose/Si and ice/trehalose/Si. The results show that there can be interactions between the layers during the bombardment process that prevent a simple interpretation of the depth profile. We find so far that the best results are obtained when the mass of the overlayer atoms is less than or nearly equal to the mass of the atoms in buried molecules. In general, these observations suggest that C{sub 60} {sup +} bombardment can be successfully applied to interface characterization of multi-layer systems if the systems are carefully chosen.

  12. A measurement system for vertical seawater profiles close to the air–sea interface

    Directory of Open Access Journals (Sweden)

    R. P. Sims

    2017-09-01

    Full Text Available This paper describes a near-surface ocean profiler, which has been designed to precisely measure vertical gradients in the top 10 m of the ocean. Variations in the depth of seawater collection are minimized when using the profiler compared to conventional CTD/rosette deployments. The profiler consists of a remotely operated winch mounted on a tethered yet free-floating buoy, which is used to raise and lower a small frame housing sensors and inlet tubing. Seawater at the inlet depth is pumped back to the ship for analysis. The profiler can be used to make continuous vertical profiles or to target a series of discrete depths. The profiler has been successfully deployed during wind speeds up to 10 m s−1 and significant wave heights up to 2 m. We demonstrate the potential of the profiler by presenting measured vertical profiles of the trace gases carbon dioxide and dimethylsulfide. Trace gas measurements use an efficient microporous membrane equilibrator to minimize the system response time. The example profiles show vertical gradients in the upper 5 m for temperature, carbon dioxide and dimethylsulfide of 0.15 °C, 4 µatm and 0.4 nM respectively.

  13. HURRICANE AND SEVERE STORM SENTINEL (HS3) GLOBAL HAWK ADVANCED VERTICAL ATMOSPHERIC PROFILING SYSTEM (AVAPS) DROPSONDE SYSTEM V2

    Data.gov (United States)

    National Aeronautics and Space Administration — The Hurricane and Severe Storm Sentinel (HS3) Global Hawk Advanced Vertical Atmospheric Profiling System (AVAPS) Dropsonde System dataset was collected by the...

  14. A robust fibre laser system for electro-optic electron bunch profile measurements at FLASH

    Energy Technology Data Exchange (ETDEWEB)

    Wissmann, Laurens-Georg

    2012-08-15

    For the electro-optic measurement of electron bunch profiles at FLASH a robust ytterbium doped fibre laser (YDFL) system has been developed consisting of a laser oscillator and a two-staged amplifier. The oscillator is designed to meet the specifications of high reliability and low noise operation. The amplifier makes use of tailored nonlinearity to enhance the spectral bandwidth of the output laser pulses. Active repetition rate control enables sub-picosecond synchronisation of the laser to the accelerator reference RF. Using a two-stage gating scheme the output pulse train repetition rate is adopted to the accelerator repetition rate. An experimental site used for electro-optic electron bunch diagnostics has been redesigned to support single-shot bunch profile measurements based on spectral decoding. An existing bunch profile monitor with a similar laser system was upgraded and electro-optic bunch profile measurements were conducted, allowing for a comparison with measurements done with other longitudinal electron bunch diagnostics and with former measurements.

  15. A robust fibre laser system for electro-optic electron bunch profile measurements at FLASH

    International Nuclear Information System (INIS)

    Wissmann, Laurens-Georg

    2012-08-01

    For the electro-optic measurement of electron bunch profiles at FLASH a robust ytterbium doped fibre laser (YDFL) system has been developed consisting of a laser oscillator and a two-staged amplifier. The oscillator is designed to meet the specifications of high reliability and low noise operation. The amplifier makes use of tailored nonlinearity to enhance the spectral bandwidth of the output laser pulses. Active repetition rate control enables sub-picosecond synchronisation of the laser to the accelerator reference RF. Using a two-stage gating scheme the output pulse train repetition rate is adopted to the accelerator repetition rate. An experimental site used for electro-optic electron bunch diagnostics has been redesigned to support single-shot bunch profile measurements based on spectral decoding. An existing bunch profile monitor with a similar laser system was upgraded and electro-optic bunch profile measurements were conducted, allowing for a comparison with measurements done with other longitudinal electron bunch diagnostics and with former measurements.

  16. Building America Top Innovations 2013 Profile – Quality Management System Guidelines

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2013-09-01

    This Top Innovation profile describes quality management system tools that were customized for residential construction by BSC, IBACOS, and PHI, for use by builders, trades, and designers to help eliminate mistakes that would require high-cost rework.

  17. Improving electronic customers' profile in recommender systems using data mining techniques

    Directory of Open Access Journals (Sweden)

    Mohammad Julashokri

    2011-10-01

    Full Text Available Recommender systems are tools for realization one to one marketing. Recommender systems are systems, which attract, retain, and develop customers. Recommender systems use several ways to make recommendations. Two ways are using more than the others: collaborative filtering and content-based filtering. In this study, a recommender system model based on collaborative filtering has proposed. Proposed model was endeavored to improve the customer profile in collaborative systems to enhance the recommender system efficiency. This improvement was done using time context and group preferences. Experimental results show that the proposed model has a better recommendation performance than existing models.

  18. Energy demand and thermal comfort of HVAC systems with thermally activated building systems as a function of user profile

    Science.gov (United States)

    Pałaszyńska, Katarzyna; Bandurski, Karol; Porowski, Mieczysław

    2017-11-01

    Thermally Activated Building Systems (TABS) are a way to use building structure as a thermal energy storage. As a result, renewable energy sources may be used more efficiently. The paper presents numerical analysis of a HVAC system with TABS energy demand and indoor thermal comfort of a representative room in a non-residential building (governmental, commercial, educational). The purpose of analysis is to investigate the influence of a user profile on system performance. The time span of the analysis is one year - a typical meteorological year. The model was prepared using a generally accepted simulation tool - TRNSYS 17. The results help to better understand the interaction of a user profile with TABS. Therefore they are important for the development of optimal control algorithms for energy efficient buildings equipped with such systems.

  19. Proceedings of the executive dialogue on resource planning and investment decisions

    International Nuclear Information System (INIS)

    Porter, K.

    1992-01-01

    At the invitation of the Secretary of the US Department of Energy (DOE), more than sixty electric utility executives met with twenty state regulators and twenty senior executives of major intervenor groups to discuss the issues that define the future of integrated resource planning (IRP). During the last decade, the concept of IRP (or least-cost planning as it was known earlier) emerged as an important utility and energy planning tool. Since 1986, IRP has been utilized, to some degree, in as many as 27 states. DOE participated in the rapid expansion of IRP through modest investments in pivotal programs and projects. The primary purpose of this meeting was to assess the status of IRP and to discuss the steps needed to strengthen its role in state and national energy policy. The one-and-one-half-day meeting began with a brief plenary session consisting of three presentations to set the context for the workshop and raise critical IRP issues by three acknowledged leaders from utilities, regulators, and intervenors. This was followed by discussions in small groups for the balance of the day. The meeting concluded with a two-part plenary session that (1) summarized the findings of the discussion groups and (2) presented conclusions and recommendations representing the collective views of each sector (utility, regulatory, and intervenor) expressed during the workshop

  20. Coupling aging immunity with a sedentary lifestyle: has the damage already been done?--a mini-review.

    Science.gov (United States)

    Simpson, Richard J; Guy, Keith

    2010-01-01

    The elderly population is at an unprecedented risk of infectious diseases and malignancy due to apparently inevitable age-related declines in immunity. The 'immune risk profile' (IRP) is an array of biomarkers that has been used to predict morbidity and mortality in older adults. As it is generally accepted that middle-aged and elderly individuals who habitually participate in moderate-intensity exercise are less likely to incur an infection than their sedentary counterparts, this review addresses current knowledge on the effects of regular exercise on aspects of adaptive immunity as they relate to the IRP. Findings from cross-sectional studies mostly show enhanced immunity in physically active compared to sedentary older adults. These include greater T-cell responsiveness to mitogens in vitro, a reduced frequency of antigen-experienced and senescent T-cells (i.e. CD45RO+/KLRG1+/CD57+/CD28-), enhanced IL-2 production and T-lymphocyte expression of the IL-2 receptor, longer chromosome telomere lengths in blood leukocytes and in vivo immune responses to vaccines and recall antigens. In contrast, the evidence from the available longitudinal studies that have used an exercise training intervention in previously sedentary elderly to improve similar immune responses is less compelling. Although this might indicate that exercise has limited immune restorative properties in previously sedentary elderly, there are still relatively few studies that have addressed specific IRP criteria and the large variation in experimental design among the longitudinal studies complicates the juxtaposition of these results. It is clear that a more substantial and focused research approach is required before physical exercise can be used in earnest as an effective immune restorative strategy in the elderly. This mini-review summarizes the major findings of these studies and proposes future avenues of research to investigate the effects of regular exercise on aspects of adaptive immunity in

  1. Policy outcomes of applying different nutrient profiling systems in recreational sports settings: the case for national harmonization in Canada.

    Science.gov (United States)

    Olstad, Dana Lee; Poirier, Kelly; Naylor, Patti-Jean; Shearer, Cindy; Kirk, Sara F L

    2015-08-01

    To assess agreement among three nutrient profiling systems used to evaluate the healthfulness of vending machine products in recreation and sport settings in three Canadian provinces. We also assessed whether the nutritional profile of vending machine items in recreation and sport facilities that were adhering to nutrition guidelines (implementers) was superior to that of facilities that were not (non-implementers). Trained research assistants audited the contents of vending machines. Three provincial nutrient profiling systems were used to classify items into each province's most, moderately and least healthy categories. Agreement among systems was assessed using weighted κ statistics. ANOVA assessed whether the average nutritional profile of vending machine items differed according to province and guideline implementation status. Eighteen recreation and sport facilities in three Canadian provinces. One-half of facilities were implementing nutrition guidelines. Snacks (n 531) and beverages (n 618) within thirty-six vending machines were audited. Overall, the systems agreed that the majority of items belonged within their respective least healthy categories (66-69 %) and that few belonged within their most healthy categories (14-22 %). Agreement among profiling systems was moderate to good, with κ w values ranging from 0·49 to 0·69. Implementers offered fewer of the least healthy items (P<0·05) and these items had a better nutritional profile compared with items in non-implementing facilities. The policy outcomes of the three systems are likely to be similar, suggesting there may be scope to harmonize nutrient profiling systems at a national level to avoid unnecessary duplication and support food reformulation by industry.

  2. Energy demand and thermal comfort of HVAC systems with thermally activated building systems as a function of user profile

    Directory of Open Access Journals (Sweden)

    Pałaszyńska Katarzyna

    2017-01-01

    Full Text Available Thermally Activated Building Systems (TABS are a way to use building structure as a thermal energy storage. As a result, renewable energy sources may be used more efficiently. The paper presents numerical analysis of a HVAC system with TABS energy demand and indoor thermal comfort of a representative room in a non-residential building (governmental, commercial, educational. The purpose of analysis is to investigate the influence of a user profile on system performance. The time span of the analysis is one year – a typical meteorological year. The model was prepared using a generally accepted simulation tool – TRNSYS 17. The results help to better understand the interaction of a user profile with TABS. Therefore they are important for the development of optimal control algorithms for energy efficient buildings equipped with such systems.

  3. Beam-scanning system for determination of beam profiles and form factors in merged-beam experiments

    International Nuclear Information System (INIS)

    Keyser, C.J.; Froelich, H.R.; Mitchell, J.B.A.; McGowan, J.W.

    1979-01-01

    A beam-scanning system for a merged electron-ion beam experiment is described. This system is used to determine the horizontal and vertical beam profiles and the form factors at three different locations along the axis of the beams. Design details of the wedge-shaped scanners and the electronic circuit for obtaining beam profiles and form factors are described. The form factor derivation for merged beams is given and an expression in terms of measured quantities is derived. (author)

  4. A Danish Profiling System

    DEFF Research Database (Denmark)

    Rosholm, Michael; Staghøj, Jonas; Svarer, Michael

    2006-01-01

    This paper describes the statistical model used for profiling new unemployed workers in Denmark. When a worker – during his or her first six months in unemployment – enters the employment office for the first time, this model predicts whether or not he or she will be unemployed for more than six ...

  5. SPSP Phase III Recruiting, Selecting, and Developing Secure Power Systems Professionals. Job Profiles

    Energy Technology Data Exchange (ETDEWEB)

    O' Neil, Lori Ross [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Conway, T. J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Tobey, D. H. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Greitzer, Frank L. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Dalton, Angela C. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Pusey, Portia K. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2015-03-01

    The Secure Power Systems Professional Phase III final report was released last year which an appendix of Job Profiles. This new report is that appendix broken out as a standalone document to assist utilities in recruiting and developing Secure Power Systems Professionals at their site.

  6. Choice of capillary electrophoresis systems for the impurity profiling of drugs

    NARCIS (Netherlands)

    Hilhorst, M.J; Somsen, G.W; de Jong, G.J.

    In order to develop a strategy for the impurity profiling of drugs, the possibilities of some capillary electrophoresis systems were investigated. A mixture containing a drug and some of its possible impurities has been used as a model problem. The test compounds were investigated by capillary zone

  7. Reactor protection system software test-case selection based on input-profile considering concurrent events and uncertainties

    International Nuclear Information System (INIS)

    Khalaquzzaman, M.; Lee, Seung Jun; Cho, Jaehyun; Jung, Wondea

    2016-01-01

    Recently, the input-profile-based testing for safety critical software has been proposed for determining the number of test cases and quantifying the failure probability of the software. Input-profile of a reactor protection system (RPS) software is the input which causes activation of the system for emergency shutdown of a reactor. This paper presents a method to determine the input-profile of a RPS software which considers concurrent events/transients. A deviation of a process parameter value begins through an event and increases owing to the concurrent multi-events depending on the correlation of process parameters and severity of incidents. A case of reactor trip caused by feedwater loss and main steam line break is simulated and analyzed to determine the RPS software input-profile and estimate the number of test cases. The different sizes of the main steam line breaks (e.g., small, medium, large break) with total loss of feedwater supply are considered in constructing the input-profile. The uncertainties of the simulation related to the input-profile-based software testing are also included. Our study is expected to provide an option to determine test cases and quantification of RPS software failure probability. (author)

  8. Estimating forest structural characteristics using the airborne LiDAR scanning system and a near-real time profiling laser system

    Science.gov (United States)

    Zhao, Kaiguang

    LiDAR (Light Detection and Ranging) directly measures canopy vertical structures, and provides an effective remote sensing solution to accurate and spatially-explicit mapping of forest characteristics, such as canopy height and Leaf Area Index. However, many factors, such as large data volume and high costs for data acquisition, precludes the operational and practical use of most currently available LiDARs for frequent and large-scale mapping. At the same time, a growing need is arising for real-time remote sensing platforms, e.g., to provide timely information for urgent applications. This study aims to develop an airborne profiling LiDAR system, featured with on-the-fly data processing, for near real- or real-time forest inventory. The development of such a system involves implementing the on-board data processing and analysis as well as building useful regression-based models to relate LiDAR measurements with forest biophysical parameters. This work established a paradigm for an on-the-fly airborne profiling LiDAR system to inventory regional forest resources in real- or near real-time. The system was developed based on an existing portable airborne laser system (PALS) that has been previously assembled at NASA by Dr. Ross Nelson. Key issues in automating PALS as an on-the-fly system were addressed, including the design of an archetype for the system workflow, the development of efficient and robust algorithms for automatic data processing and analysis, the development of effective regression models to predict forest biophysical parameters from LiDAR measurements, and the implementation of an integrated software package to incorporate all the above development. This work exploited the untouched potential of airborne laser profilers for real-time forest inventory, and therefore, documented an initial step toward developing airborne-laser-based, on-the-fly, real-time, forest inventory systems. Results from this work demonstrated the utility and effectiveness of

  9. Heterogeneity of Systemic Oxidative Stress Profiles in COPD: A Potential Role of Gender

    Directory of Open Access Journals (Sweden)

    Jonathan Maury

    2015-01-01

    Full Text Available Oxidative stress (OS plays a key role in the muscle impairment and exercise capacity of COPD patients. However, the literature reveals that systemic OS markers show great heterogeneity, which may hinder the prescription of effective antioxidant supplementation. This study therefore aimed to identify OS markers imbalance of COPD patients, relative to validated normal reference values, and to investigate the possibility of systemic OS profiles. We measured systemic enzymatic/nonenzymatic antioxidant and lipid peroxidation (LP levels in 54 stable COPD patients referred for a rehabilitation program. The main systemic antioxidant deficits in these patients concerned vitamins and trace elements. Fully 89% of the COPD patients showed a systemic antioxidant imbalance which may have caused the elevated systemic LP levels in 69% of them. Interestingly, two patient profiles (clusters 3 and 4 had a more elevated increase in LP combined with increased copper and/or decreased vitamin C, GSH, and GPx. Further analysis revealed that the systemic LP level was higher in COPD women and associated with exercise capacity. Our present data therefore support future supplementations with antioxidant vitamins and trace elements to improve exercise capacity, but COPD patients will probably show different positive responses.

  10. PROFIL-360 high resolution steam generator tube profilometry system

    International Nuclear Information System (INIS)

    Glass, S.W.

    1985-01-01

    A high-resolution profilometry system, PROFIL 360, has been developed to assess the condition of steam generator tubes and rapidly produce the data to evaluate the potential for developing in-service leaks. The probe has an electromechanical sensor in a rotating head. This technique has been demonstrated in the field, saving tubes that would have been plugged with the go-gauge criterion and indicating plugging other high-risk candidates that might otherwise not have been removed from service

  11. Profil-360 high resolution steam generator tube profilometry system

    International Nuclear Information System (INIS)

    Glass, S.W.

    1985-01-01

    A high-resolution profilometry system, PROFIL 360, has been developed to assess the condition of steam generator tubes and rapidly produce the data to evaluate the potential for developing in-service leaks. The probe has an electromechanical sensor in a rotating head. This technique has been demonstrated in the field, saving tubes that would have been plugged with the go-gauge criterion and indicating plugging other high-risk candidates that might otherwise not have been removed from service

  12. Genome-wide analysis of immune system genes by EST profiling

    Science.gov (United States)

    Giallourakis, Cosmas; Benita, Yair; Molinie, Benoit; Cao, Zhifang; Despo, Orion; Pratt, Henry E.; Zukerberg, Lawrence R.; Daly, Mark J.; Rioux, John D.; Xavier, Ramnik J.

    2013-01-01

    Profiling studies of mRNA and miRNA, particularly microarray-based studies, have been extensively used to create compendia of genes that are preferentially expressed in the immune system. In some instances, functional studies have been subsequently pursued. Recent efforts such as ENCODE have demonstrated the benefit of coupling RNA-Seq analysis with information from expressed sequence tags (ESTs) for transcriptomic analysis. However, the full characterization and identification of transcripts that function as modulators of human immune responses remains incomplete. In this study, we demonstrate that an integrated analysis of human ESTs provides a robust platform to identify the immune transcriptome. Beyond recovering a reference set of immune-enriched genes and providing large-scale cross-validation of previous microarray studies, we discovered hundreds of novel genes preferentially expressed in the immune system, including non-coding RNAs. As a result, we have established the Immunogene database, representing an integrated EST “road map” of gene expression in human immune cells, which can be used to further investigate the function of coding and non-coding genes in the immune system. Using this approach, we have uncovered a unique metabolic gene signature of human macrophages and identified PRDM15 as a novel overexpressed gene in human lymphomas. Thus we demonstrate the utility of EST profiling as a basis for further deconstruction of physiologic and pathologic immune processes. PMID:23616578

  13. A Comparison of Clinical Outcomes with Regular- and Low-Profile Totally Implanted Central Venous Port Systems

    International Nuclear Information System (INIS)

    Teichgraeber, Ulf Karl-Martin; Steitparth, Florian; Cho, Chie Hee; Benter, Thomas; Gebauer, Bernhard

    2009-01-01

    The purpose of this study was to evaluate whether low-profile totally implanted central venous port systems can reduce the late complication of skin perforation. Forty patients (age, 57 ± 13 years; 22 females, 18 males) were randomized for the implantation of a low-profile port system, and another 40 patients (age, 61 ± 14 years; 24 females, 16 males) received a regular port system as control group. Indications for port catheter implantation were malignant disease requiring chemotherapy. All port implantations were performed in the angiography suite using sonographically guided central venous puncture and fluoroscopic guidance of the catheter placement. Procedure time, number of complications (procedure-related immediate, early, and late complications), and number of explantations were assessed. Follow-up was performed for 6 months. All port implantations were successfully completed in both study groups. There were two incidents of skin perforation observed in the control group. One skin perforation occurred 13 weeks and the other 16 weeks after port implantation (incidence, 5%) in patients with regular-profile port systems. Two infections were observed, one port infection in each study group. Both infections were characterized as catheter-related infections (infection rate: 0.15 catheter-related infections per 1000 catheter days). In conclusion, low-profile port systems can be placed as safely as traditional chest ports and reduce the risk of developing skin perforations, which occurs when the port system is too tight within the port pocket.

  14. The circulating cell-free microrna profile in systemic sclerosis is distinct from both healthy controls and Systemic Lupus Erythematosus

    DEFF Research Database (Denmark)

    Steen, S. O.; Iversen, L. V.; Carlsen, A. L.

    2015-01-01

    Objective. To evaluate the expression profile of cell-free circulating microRNA (miRNA) in systemic sclerosis (SSc), healthy controls (HC), and systemic lupus erythematosus (SLE). Methods. Total RNA was purified from plasma and 45 different, mature miRNA were measured using quantitative PCR assays...

  15. Provider Profiling: A Population Health Improvement Tool for the Southeast Military Health System

    National Research Council Canada - National Science Library

    Pemberton, Phillip

    1999-01-01

    ...). Profiling with Provider Perspectives, a Primary Care Management Tool, provides the SEMHS with a standardized performance measurement system that offers feedback in a user friendly and non-threatening format...

  16. The Impact of Heller Myotomy on Integrated Relaxation Pressure in Esophageal Achalasia.

    Science.gov (United States)

    Salvador, Renato; Savarino, Edoardo; Pesenti, Elisa; Spadotto, Lorenzo; Capovilla, Giovanni; Cavallin, Francesco; Galeazzi, Francesca; Nicoletti, Loredana; Merigliano, Stefano; Costantini, Mario

    2016-01-01

    A new high-resolution manometry (HRM) parameter, the integrated relaxation pressure (IRP), has been proposed for the assessment of esophageal-gastric junction (EGJ) relaxation. Our aim was to assess the effect of Heller myotomy on IRP in achalasia patients. We prospectively collected data on achalasia patients who underwent HRM between 2009-2014. Barium swallow was used to assess esophageal diameter and shape. Manometric diagnoses were performed by using the Chicago Classification v3. All patients with a confirmed diagnosis of achalasia were treated surgically with Heller Myotomy One hundred thirty-nine consecutive achalasia patients (M:F = 72:67) represented the study population. All the patients had 100% simultaneous waves but 11 had an IRP achalasia, and how it changes after surgical treatment. An increased preoperative IRP correlated directly with a more severe dysphagia. The IRP was restored to normal by Heller myotomy.

  17. Integration of polystyrene microlenses with both convex and concave profiles in a polymer-based microfluidic system

    KAUST Repository

    Fan, Yiqiang

    2013-12-20

    This paper reports a new technique of fabricating polystyrene microlenses with both convex and concave profiles that are integrated in polymer-based microfluidic system. The polystyrene microlenses, or microlens array, are fabricated using the free-surface thermal compression molding method. The laser fabricated poly(methyl methacrylate) (PMMA) sheet is used as the mold for the thermal compression molding process. With different surface treatment methods of the PMMA mold, microlenses with either convex or concave profiles could be achieved during the thermal molding process. By integrating the microlenses in the microfluidic systems, observing the flow inside the microchannels is easier. This new technique is rapid, low cost, and it does not require cleanroom facilities. Microlenses with both convex and concave profiles can be easily fabricated and integrated in microfluidic system with this technique. © 2013 Springer-Verlag Berlin Heidelberg.

  18. Cardiac Autonomic Nervous System Activation and Metabolic Profile in Young Children : The ABCD Study

    NARCIS (Netherlands)

    Vrijkotte, Tanja G M; van den Born, Bert-Jan H; Hoekstra, Christine M C A; Gademan, Maaike G J; van Eijsden, Manon; de Rooij, Susanne R; Twickler, Marcel T B

    2015-01-01

    BACKGROUND: In adults, increased sympathetic and decreased parasympathetic nervous system activity are associated with a less favorable metabolic profile. Whether this is already determined at early age is unknown. Therefore, we aimed to assess the association between autonomic nervous system

  19. Decision support system for determining Bantuan Siswa Miskin (BSM) receivers with profile matching method

    Science.gov (United States)

    Situmorang, B. H.; Pibriana, E.; Tosida, E. T.

    2018-03-01

    Bantuan Siswa Miskin (BSM) is a National Programs aimed at eliminating the barriers of poor students participating to school by helping poor students gain access to appropriate education services, prevent dropping out of school, attract poor students back to school, assis students in providing for learning activities, support the Nine Years Basic Education (and even up to senior high school) program, as well as helping to smooth the school programs [1]. Decision Support System is made by applying Profile Matching method to assist teachers or school operators in SMP PGRI Ciasmara in selecting prospective recipients of BSM program and providing recommendations in decision making. Profile Matching is used to compare the actual data value of a profile to be assessed by the expected profile value, so that it can be known the difference of competence (also called GAP). If the resulting value of GAP is smaller then the weight of value will be greater, which means it has a greater chance to be recommended as a potential recipient of the BSM program. Decision Support System for determining BSM receivers is only choosing the right alternatives to receive BSM according to the BSM quota given to SMP PGRI Ciasmara. The right alternatives to receive this BSM is the highest ranking alternatives.

  20. Design and verification of the miniature optical system for small object surface profile fast scanning

    Science.gov (United States)

    Chi, Sheng; Lee, Shu-Sheng; Huang, Jen, Jen-Yu; Lai, Ti-Yu; Jan, Chia-Ming; Hu, Po-Chi

    2016-04-01

    As the progress of optical technologies, different commercial 3D surface contour scanners are on the market nowadays. Most of them are used for reconstructing the surface profile of mold or mechanical objects which are larger than 50 mm×50 mm× 50 mm, and the scanning system size is about 300 mm×300 mm×100 mm. There are seldom optical systems commercialized for surface profile fast scanning for small object size less than 10 mm×10 mm×10 mm. Therefore, a miniature optical system has been designed and developed in this research work for this purpose. Since the most used scanning method of such system is line scan technology, we have developed pseudo-phase shifting digital projection technology by adopting projecting fringes and phase reconstruction method. A projector was used to project a digital fringe patterns on the object, and the fringes intensity images of the reference plane and of the sample object were recorded by a CMOS camera. The phase difference between the plane and object can be calculated from the fringes images, and the surface profile of the object was reconstructed by using the phase differences. The traditional phase shifting method was accomplished by using PZT actuator or precisely controlled motor to adjust the light source or grating and this is one of the limitations for high speed scanning. Compared with the traditional optical setup, we utilized a micro projector to project the digital fringe patterns on the sample. This diminished the phase shifting processing time and the controlled phase differences between the shifted phases become more precise. Besides, the optical path design based on a portable device scanning system was used to minimize the size and reduce the number of the system components. A screwdriver section about 7mm×5mm×5mm has been scanned and its surface profile was successfully restored. The experimental results showed that the measurement area of our system can be smaller than 10mm×10mm, the precision reached to

  1. Profile and Role of Woman Involvement in Dry System Pig Farming

    Directory of Open Access Journals (Sweden)

    Hartoko Hartoko

    2004-01-01

    Full Text Available This research was purposed to study the profile and role of woman involvement in dry system pig farming (pig housing with mattress from grass, pig manure, vegetable waste and kitchen waste.  The research was carried out from August to November 2003.  Pig housing areas were located on eight villages of Kertek District in Wonosobo Regency (Central Java.  The method applied was survey with intensive observation.  Sample were randomly selected, involved 180 respondents (15 percent of total pig farmers, while the locations of the sample were selected based on purposive sampling method.  The result showed that respondents were in productive age, with low formal education level. Most of all are Moslems (98% and they have small family size.  The level of woman involvement in pig farming was high, approximately 85 percent.  They have other income source and they involve in pig farming to help their husbands in generating income.  Experience in the dry system pig farming was quite long (more than 10 years and skill come from imitating their neighbours otherwise of autodidact. (Animal Production 6(1: 23-29 (2004   Key Words: Pig, Dry System, Woman Profile and Role

  2. X-ray cross-sections and crossroads (The International Radiation Physics Society) - Richard Pratt's contributions to both

    International Nuclear Information System (INIS)

    Hubbell, J.H.

    2000-01-01

    Some examples of the impact of the theoretical contributions by Richard Pratt and his collaborators on photon cross section compilations at NBS/NIST and elsewhere over the past several decades are presented. Both the theoretical and measurement works which combine to provide this data base, and the contact with the varied user groups in medical applications, nuclear engineering, crystallography and X-ray astronomy, have formed a global crossroads of researchers now embodied in the International Radiation Physics Society (IRPS). Since the founding of the IRPS at the 3 rd International Symposium on Radiation Physics (ISRP-3) in Ferrara, Italy, in 1985, the Secretariat for this 'global radiation physics family' (the IRPS) has resided at the University of Pittsburgh under the direction of Richard Pratt. A brief account of the origins and history of the IRPS, beginning with ISRP-1 in Calcutta in 1974, is presented.

  3. X-ray cross-sections and crossroads (The International Radiation Physics Society) - Richard Pratt's contributions to both

    Science.gov (United States)

    Hubbell, J. H.

    2000-08-01

    Some examples of the impact of the theoretical contributions by Richard Pratt and his collaborators on photon cross section compilations at NBS/NIST and elsewhere over the past several decades are presented. Both the theoretical and measurement works which combine to provide this data base, and the contact with the varied user groups in medical applications, nuclear engineering, crystallography and X-ray astronomy, have formed a global crossroads of researchers now embodied in the International Radiation Physics Society (IRPS). Since the founding of the IRPS at the 3rd International Symposium on Radiation Physics (ISRP-3) in Ferrara, Italy, in 1985, the Secretariat for this ``global radiation physics family'' (the IRPS) has resided at the University of Pittsburgh under the direction of Richard Pratt. A brief account of the origins and history of the IRPS, beginning with ISRP-1 in Calcutta in 1974, is presented.

  4. Determination and evaluation of the best conditions for the production of a vaccine against Clostridium chauvoei

    Directory of Open Access Journals (Sweden)

    Jorge Humberto Ossa

    2005-05-01

    Full Text Available Clostridium chauvoei is responsible for a number of diseases such as symptomatic coal (blackleg and malignant oedema in cattle, sheep and many other domestic and wild animals. Vaccines for the control of this and other livestock diseases caused by various species of clostridia are widely used. For vaccine production it is desirable that high cellular density cultures with high immunogenic power are obtained, mainly because immunity to Clostridium chauvoei is generally considered to be antibacterial rather than antitoxic. Consequently, culture conditions have to be adequately monitored and controlled. The aim of this work was to optimise the production of a vaccine against Clostridium chauvoei based on strains IRP-434, IRP 206, ATCC 10092, ATCC 11957 and LANIP, used by “Empresa Colombiana de Productos Veterinarios”, VECOL, S.A., to determine the culture medium that allows the highest cellular density. Results show that modified clostridium medium allows the highest cellular density production with average values of 31,5X108 cell/ml for the stock IRP 434 and 31,8X108 cell/ml for the stock IRP 206. Once defined the modified clostridium medium, the stock IRP 434,IRP 206 and growth time as the most suitable for optimal biomass production ( 16 – 48 hours, the lethal activity of the stock (LD50 = 106.6 , 106.8 was determined, the immunogenicity was evaluated through a potency test carried out in guinea-pigs. The presence of the flagellar protein was confirmed through the SDS-PAGE electrophoresis technique.

  5. Treatment of esophageal motility disorders based on the chicago classification.

    Science.gov (United States)

    Maradey-Romero, Carla; Gabbard, Scott; Fass, Ronnie

    2014-12-01

    The Chicago Classification divides esophageal motor disorders based on the recorded value of the integrated relaxation pressure (IRP). The first group includes those with an elevated mean IRP that is associated with peristaltic abnormalities such as achalasia and esophagogastric junction outflow obstruction. The second group includes those with a normal mean IRP that is associated with esophageal hypermotility disorders such as distal esophageal spasm, hypercontractile esophagus (jackhammer esophagus), and hypertensive peristalsis (nutcracker esophagus). The third group includes those with a normal mean IRP that is associated with esophageal hypomotility peristaltic abnormalities such as absent peristalsis, weak peristalsis with small or large breaks, and frequent failed peristalsis. The therapeutic options vary greatly between the different groups of esophageal motor disorders. In achalasia patients, potential treatment strategies comprise medical therapy (calcium channel blockers, nitrates, and phosphodiesterase 5 inhibitors), endoscopic procedures (botulinum toxin A injection, pneumatic dilation, or peroral endoscopic myotomy) or surgery (Heller myotomy). Patients with a normal IRP and esophageal hypermotility disorder are candidates for medical therapy (nitrates, calcium channel blockers, phosphodiesterase 5 inhibitors, cimetropium/ipratropium bromide, proton pump inhibitors, benzodiazepines, tricyclic antidepressants, trazodone, selective serotonin reuptake inhibitors, and serotonin-norepinephrine reuptake inhibitors), endoscopic procedures (botulinum toxin A injection and peroral endoscopic myotomy), or surgery (Heller myotomy). Lastly, in patients with a normal IRP and esophageal hypomotility disorder, treatment is primarily focused on controlling the presence of gastroesophageal reflux with proton pump inhibitors and lifestyle modifications (soft and liquid diet and eating in the upright position) to address patient's dysphagia.

  6. Profiles of Automotive Suppliers Industries--Engineered Mechanical Components and Systems : Volume II, Appendices.

    Science.gov (United States)

    1981-09-01

    The profile describes and analyzes that segment of the automotive supplier industry which provides engineered mechanical components/assemblies/systems to the prime auto manufacturers. It presents an overview of the role and structure of this industry...

  7. Profiles of Automotive Suppliers Industries--Engineered Mechanical Components and Systems : Volume I, Text.

    Science.gov (United States)

    1981-09-01

    This profile describes and analyzes that segment of the automotive supplier industry which provides engineered mechanical components/assemblies/systems to the prime auto manufacturers. It presents an overview of the role and structure of this industr...

  8. Research and application of online measurement system of tire tread profile in automobile tire production

    Science.gov (United States)

    Wang, Pengyao; Chen, Xiangguang; Yang, Kai; Liu, Xuejiao

    2017-01-01

    To improve the measuring efficiency of width and thickness of tire tread in the process of automobile tire production, the actual condition for the tire production process is analyzed, and a fast online measurement system based on moving tire tread of tire specifications is established in this paper. The coordinate data of tire tread profile is acquired by 3D laser sensor, and we use C# language for programming which is an object-oriented programming language to complete the development of client program. The system with laser sensor can provide real-time display of tire tread profile and the data to require in the process of tire production. Experimental results demonstrate that the measuring precision of the system is <= 1mm, it can meet the measurement requirements of the production process, and the system has the characteristics of convenient installation and testing, system stable operation.

  9. Performance evaluation of lanthanum bromide and sodium iodide radiological identifiers for measurements in open environments; Avaliação de desempenho de identificadores radiológicos de brometo de lantânio e iodeto de sódio para medições em ambientes abertos

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira, Luciano Santa Rita; Amorim, Aneuri de; Balthar, Mario Cesar V.; Santos, Avelino dos; Vilela, Paulo Ricardo T. de; Silva, Thiago de Medeiros Silveira; Vieira, Fábio Gomes, E-mail: lucianosantarita@gmail.com [Centro Tecnológico do Exército (IDQBRN/CTEx), Rio de Janeiro, RJ (Brazil). Instituto de Defesa Química, Biológica, Radiológica e Nuclear; Cardoso, Domingos D’Oliveira; Izidório, Ana Carolina dos Anjos da Cruz [Instituto Militar de Engenharia (IME), Rio de Janeiro, RJ (Brazil); Arbach, Mayara Nascimento [Instituto de Radioproteção e Dosimetria (IRD/CNEN-RJ), Rio de Janeiro, RJ (Brazil)

    2017-07-01

    The identification of radionuclides in open environments using portable radiological identifiers (IRP) with scintillators is fundamental for the performance of the operational teams of the Brazilian Army Institute of Chemical, Biological, Radiological and Nuclear Defense (IDQBRN). The response of the IRPs used in these measurements is of great importance in the field actions of the operational team aiming at reducing exposure and also for the population. The purpose of this work is to analyze the reliability of the IRP response of lanthanum bromide and sodium iodide by the measurement of the I-152, Cs-137 and Co-60 radioactive standards. (author)

  10. MEMBRANE ACTION IN PROFILED STEEL SHEETING DRY BOARD (PSSDB FLOOR SLAB SYSTEM

    Directory of Open Access Journals (Sweden)

    MAHMOOD SERAJI

    2013-02-01

    Full Text Available Profiled steel sheeting dry board (PSSDB system is a lightweight composite structural system that made of the profiled steel sheeting (PSS connected to the dry board (DB by self-drilling and self-tapping screws. The objective of this paper is to study the effect of membrane action in improving the flexural capacities of the PSSDB system. According to the literatures, common failure of the PSSDB floor is due to local buckling in the top flanges of steel sheeting at the centre of a simply supported slab. Restraining the horizontal movement at supports may develop the membrane action (MA in the slab that can remarkably enhance the flexural rigidities of the floor. Experimental tests were conducted along with developing nonlinear finite element model to explore the effect of MA in the PSSDB floor. Experimental results of the PSSDB panel with simply end support were exploited to verify the nonlinear finite element results. The developed finite element model was then modified by restraining the horizontal movement of the slab at the supports. The obtained results disclosed that the developed compressive membrane action enhanced the stiffness of the slab at serviceability load by about 240%.

  11. Control of Sewer systems and Wastewater treatment plants using pollutant concentration profiles

    DEFF Research Database (Denmark)

    Bechmann, Henrik; Nielsen, Marinus K.; Madsen, Henrik

    1998-01-01

    On-line measurements of pollutants in the wastewater combined with grey-box modelling are used to estimate the amount of deposits in the sewer system. The pollutant mass flow at the wastewater treatment plant is found to consist of a diurnal profile minus the deposited amount of pollutants...

  12. Device- and service profiles for integrated or systems based on open standards

    Directory of Open Access Journals (Sweden)

    Mildner Alexander

    2015-09-01

    Full Text Available Integrated OR systems nowadays are closed and proprietary, so that the interconnection of components from third-party vendors is only possible with high time and cost effort. An integrated operating theatre with open interfaces, giving clinical operators the opportunity to choose individual medical devices from different manufacturers, is currently being developed in the framework of the BMBF (Federal Ministry of Education and Research funded project OR.NET [1]. Actual standards and concepts regarding technical feasibility and accreditation process do not cope with the requirements for modular integration based on an open standard. Therefore, strategies as well as service and device profiles to enable a procedure for risk management and certifiability are in the focus of the project work. Amongst others, a concept for User Interface Profiles (UI-Profiles has been conceived in order to describe medical device functions and the entire user interface regarding Human-Machine-Interaction (HMI characteristics with the aim to identify human-induced risks of central user interfaces. The use of standardized device and service profiles shall allow the manufacturers to integrate their medical devices in the OR.NET network, without disclosing the medical devices’ risk analysis and related confidential knowledge or proprietary information.

  13. Entropy of gravitating systems: scaling laws versus radial profiles

    International Nuclear Information System (INIS)

    Pesci, Alessandro

    2007-01-01

    Through the consideration of spherically symmetric gravitating systems consisting of perfect fluids with linear equation of state constrained to be in a finite volume, an account is given of the properties of entropy at conditions in which it is no longer an extensive quantity (it does not scale with the system's size). To accomplish this, the methods introduced by Oppenheim (2003 Phys. Rev.E 68 016108) to characterize non-extensivity are used, suitably generalized to the case of gravitating systems subject to an external pressure. In particular when, far from the system's Schwarzschild limit, both area scaling for conventional entropy and inverse radius law for the temperature set in (i.e. the same properties of the corresponding black hole thermodynamical quantities), the entropy profile is found to behave like 1/r, with r the area radius inside the system. In such circumstances entropy heavily resides in internal layers, in opposition to what happens when area scaling is gained while approaching the Schwarzschild mass, in which case conventional entropy lies at the surface of the system. The information content of these systems, even if it globally scales like the area, is then stored in the whole volume, instead of packed on the boundary

  14. Development of a Climatology of Vertically Complete Wind Profiles from Doppler Radar Wind Profiler Systems

    Science.gov (United States)

    Barbre, Robert E., Jr.

    2015-01-01

    This paper describes in detail the QC and splicing methodology for KSC's 50- and 915-MHz DRWP measurements that generates an extensive archive of vertically complete profiles from 0.20-18.45 km. The concurrent POR from each archive extends from April 2000 to December 2009. MSFC NE applies separate but similar QC processes to each of the 50- and 915-MHz DRWP archives. DRWP literature and data examination provide the basis for developing and applying the automated and manual QC processes on both archives. Depending on the month, the QC'ed 50- and 915-MHz DRWP archives retain 52-65% and 16-30% of the possible data, respectively. The 50- and 915-MHz DRWP QC archives retain 84-91% and 85-95%, respectively, of all the available data provided that data exist in the non- QC'ed archives. Next, MSFC NE applies an algorithm to splice concurrent measurements from both DRWP sources. Last, MSFC NE generates a composite profile from the (up to) five available spliced profiles to effectively characterize boundary layer winds and to utilize all possible 915-MHz DRWP measurements at each timestamp. During a given month, roughly 23,000-32,000 complete profiles exist from 0.25-18.45 km from the composite profiles' archive, and approximately 5,000- 27,000 complete profiles exist from an archive utilizing an individual 915-MHz DRWP. One can extract a variety of profile combinations (pairs, triplets, etc.) from this sample for a given application. The sample of vertically complete DRWP wind measurements not only gives launch vehicle customers greater confidence in loads and trajectory assessments versus using balloon output, but also provides flexibility to simulate different DOL situations across applicable altitudes. In addition to increasing sample size and providing more flexibility for DOL simulations in the vehicle design phase, the spliced DRWP database provides any upcoming launch vehicle program with the capability to utilize DRWP profiles on DOL to compute vehicle steering

  15. Elevated intrabolus pressure identifies obstructive processes when integrated relaxation pressure is normal on esophageal high-resolution manometry.

    Science.gov (United States)

    Quader, Farhan; Reddy, Chanakyaram; Patel, Amit; Gyawali, C Prakash

    2017-07-01

    Elevated integrated relaxation pressure (IRP) on esophageal high-resolution manometry (HRM) identifies obstructive processes at the esophagogastric junction (EGJ). Our aim was to determine whether intrabolus pressure (IBP) can identify structural EGJ processes when IRP is normal. In this observational cohort study, adult patients with dysphagia and undergoing HRM were evaluated for endoscopic evidence of structural EGJ processes (strictures, rings, hiatus hernia) in the setting of normal IRP. HRM metrics [IRP, distal contractile integral (DCI), distal latency (DL), IBP, and EGJ contractile integral (EGJ-CI)] were compared among 74 patients with structural EGJ findings (62.8 ± 1.6 yr, 67.6% women), 27 patients with normal EGD (52.9 ± 3.2 yr, 70.3% women), and 21 healthy controls (27.6 ± 0.6 yr, 52.4% women). Findings were validated in 85 consecutive symptomatic patients to address clinical utility. In the primary cohort, mean IBP (18.4 ± 0.9 mmHg) was higher with structural EGJ findings compared with dysphagia with normal EGD (13.5 ± 1.1 mmHg, P = 0.002) and healthy controls (10.9 ± 0.9 mmHg, P 0.05 for each comparison). During multiple rapid swallows, IBP remained higher in the structural findings group compared with controls ( P = 0.02). Similar analysis of the prospective validation cohort confirmed IBP elevation in structural EGJ processes, but correlation with dysphagia could not be demonstrated. We conclude that elevated IBP predicts the presence of structural EGJ processes even when IRP is normal, but correlation with dysphagia is suboptimal. NEW & NOTEWORTHY Integrated relaxation pressure (IRP) above the upper limit of normal defines esophageal outflow obstruction using high-resolution manometry. In patients with normal IRP, elevated intrabolus pressure (IBP) can be a surrogate marker for a structural restrictive or obstructive process at the esophagogastric junction (EGJ). This has the potential to augment the clinical value of

  16. The impact of instant reward programs and bonus premiums on consumer purchase behavior

    NARCIS (Netherlands)

    Minnema, Alec; Bijmolt, Tammo H. A.; Non, Marielle C.

    This study examines the impact of an instant reward program (IRP) with bonus premiums on consumer purchase behavior. An IRP is a rapidly growing form of short-term program that rewards consumers instantly with small premiums per fixed spending, where these premiums are part of a larger set of

  17. Human Research Program Integrated Research Plan. Revision A January 2009

    Science.gov (United States)

    2009-01-01

    The Integrated Research Plan (IRP) describes the portfolio of Human Research Program (HRP) research and technology tasks. The IRP is the HRP strategic and tactical plan for research necessary to meet HRP requirements. The need to produce an IRP is established in HRP-47052, Human Research Program - Program Plan, and is under configuration management control of the Human Research Program Control Board (HRPCB). Crew health and performance is critical to successful human exploration beyond low Earth orbit. The Human Research Program (HRP) is essential to enabling extended periods of space exploration because it provides knowledge and tools to mitigate risks to human health and performance. Risks include physiological and behavioral effects from radiation and hypogravity environments, as well as unique challenges in medical support, human factors, and behavioral or psychological factors. The Human Research Program (HRP) delivers human health and performance countermeasures, knowledge, technologies and tools to enable safe, reliable, and productive human space exploration. Without HRP results, NASA will face unknown and unacceptable risks for mission success and post-mission crew health. This Integrated Research Plan (IRP) describes HRP s approach and research activities that are intended to address the needs of human space exploration and serve HRP customers and how they are integrated to provide a risk mitigation tool. The scope of the IRP is limited to the activities that can be conducted with the resources available to the HRP; it does not contain activities that would be performed if additional resources were available. The timescale of human space exploration is envisioned to take many decades. The IRP illustrates the program s research plan through the timescale of early lunar missions of extended duration.

  18. Adaptive neuro-fuzzy inference system for temperature and humidity profile retrieval from microwave radiometer observations

    Science.gov (United States)

    Ramesh, K.; Kesarkar, A. P.; Bhate, J.; Venkat Ratnam, M.; Jayaraman, A.

    2015-01-01

    The retrieval of accurate profiles of temperature and water vapour is important for the study of atmospheric convection. Recent development in computational techniques motivated us to use adaptive techniques in the retrieval algorithms. In this work, we have used an adaptive neuro-fuzzy inference system (ANFIS) to retrieve profiles of temperature and humidity up to 10 km over the tropical station Gadanki (13.5° N, 79.2° E), India. ANFIS is trained by using observations of temperature and humidity measurements by co-located Meisei GPS radiosonde (henceforth referred to as radiosonde) and microwave brightness temperatures observed by radiometrics multichannel microwave radiometer MP3000 (MWR). ANFIS is trained by considering these observations during rainy and non-rainy days (ANFIS(RD + NRD)) and during non-rainy days only (ANFIS(NRD)). The comparison of ANFIS(RD + NRD) and ANFIS(NRD) profiles with independent radiosonde observations and profiles retrieved using multivariate linear regression (MVLR: RD + NRD and NRD) and artificial neural network (ANN) indicated that the errors in the ANFIS(RD + NRD) are less compared to other retrieval methods. The Pearson product movement correlation coefficient (r) between retrieved and observed profiles is more than 92% for temperature profiles for all techniques and more than 99% for the ANFIS(RD + NRD) technique Therefore this new techniques is relatively better for the retrieval of temperature profiles. The comparison of bias, mean absolute error (MAE), RMSE and symmetric mean absolute percentage error (SMAPE) of retrieved temperature and relative humidity (RH) profiles using ANN and ANFIS also indicated that profiles retrieved using ANFIS(RD + NRD) are significantly better compared to the ANN technique. The analysis of profiles concludes that retrieved profiles using ANFIS techniques have improved the temperature retrievals substantially; however, the retrieval of RH by all techniques considered in this paper (ANN, MVLR and

  19. Economic information from Smart Meter: Nexus Between Demand Profile and Electricity Retail Price Between Demand Profile and Electricity Retail Price

    OpenAIRE

    Yu, Yang; Liu, Guangyi; Zhu, Wendong; Wang, Fei; Shu, Bin; Zhang, Kai; Rajagopal, Ram; Astier, Nicolas

    2016-01-01

    In this paper, we demonstrate that a consumer's marginal system impact is only determined by their demand profile rather than their demand level. Demand profile clustering is identical to cluster consumers according to their marginal impacts on system costs. A profile-based uniform-rate price is economically efficient as real-time pricing. We develop a criteria system to evaluate the economic efficiency of an implemented retail price scheme in a distribution system by comparing profile cluste...

  20. Performance profiling for brachytherapy applications

    Science.gov (United States)

    Choi, Wonqook; Cho, Kihyeon; Yeo, Insung

    2018-05-01

    In many physics applications, a significant amount of software (e.g. R, ROOT and Geant4) is developed on novel computing architectures, and much effort is expended to ensure the software is efficient in terms of central processing unit (CPU) time and memory usage. Profiling tools are used during the evaluation process to evaluate the efficiency; however, few such tools are able to accommodate low-energy physics regions. To address this limitation, we developed a low-energy physics profiling system in Geant4 to profile the CPU time and memory of software applications in brachytherapy applications. This paper describes and evaluates specific models that are applied to brachytherapy applications in Geant4, such as QGSP_BIC_LIV, QGSP_BIC_EMZ, and QGSP_BIC_EMY. The physics range in this tool allows it to be used to generate low energy profiles in brachytherapy applications. This was a limitation in previous studies, which caused us to develop a new profiling tool that supports profiling in the MeV range, in contrast to the TeV range that is supported by existing high-energy profiling tools. In order to easily compare the profiling results between low-energy and high-energy modes, we employed the same software architecture as that in the SimpliCarlo tool developed at the Fermilab National Accelerator Laboratory (FNAL) for the Large Hadron Collider (LHC). The results show that the newly developed profiling system for low-energy physics (less than MeV) complements the current profiling system used for high-energy physics (greater than TeV) applications.

  1. Automatic tuning of Bragg condition in a radio-acoustic system for PBL temperature profile measurement

    Energy Technology Data Exchange (ETDEWEB)

    Bonino, G; Trivero, P

    1985-01-01

    A Radio-Acoustic Sounding System (RASS) with acoustic wavelength lambda/sub a/ approx. 1m was designed and successfully tested. The system proved to be capable of measuring the vertical temperature profile in the Planetary Boundary Layer (PBL) with an accuracy and vertical resolution comparable to that of traditional apparatus (radiothermosondes borne by tethered or disposable balloons, thermosondes borne by aircraft and so on), yet combined with the advantages typical of remote sensing techniques. Up to the summer of 1983 the system needed attendance by an operator who had to identify the acoustic sounding frequency affording the fundamental condition of Bragg resonance between acoustic and radio wavelengths. Features and performance of the new completely automatic RASS arrangement are presented. These include the possibility of obtaining average thermal vertical profiles at preset time intervals. Maximum range of the possibility of obtaining average thermal vertical profiles at preset time intervals. Maximum range of measurements obtained in about 1000 1/2-h averages was: in 90% of cases greater than or equal to 600 m; in 50% of cases greater than or equal to 1100m. Such results indicate the usefulness of automatic RASS as a tool for meteorological purposes and for the application of air pollution control strategies.

  2. Microscopic image processing system for measuring nonuniform film thickness profiles: Image scanning ellipsometry

    International Nuclear Information System (INIS)

    Liu, A.H.; Plawsky, J.L.; Wayner, P.C. Jr.

    1993-01-01

    The long-term objective of this research program is to determine the stability and heat transfer characteristics of evaporating thin films. The current objective is to develop and use a microscopic image-processing system (IPS) which has two parts: an image analyzing interferometer (IAI) and an image scanning ellipsometer (ISE). The primary purpose of this paper is to present the basic concept of ISE, which is a novel technique to measure the two dimensional thickness profile of a non-uniform, thin film, from several nm up to several μm, in a steady state as well as in a transient state. It is a full-field imaging technique which can study every point on the surface simultaneously with high spatial resolution and thickness sensitivity, i.e., it can measure and map the 2-D film thickness profile. The ISE was tested by measuring the thickness profile and the refractive index of a nonuniform solid film

  3. Plasma Exosome Profiling of Cancer Patients by a Next Generation Systems Biology Approach.

    Science.gov (United States)

    Domenyuk, Valeriy; Zhong, Zhenyu; Stark, Adam; Xiao, Nianqing; O'Neill, Heather A; Wei, Xixi; Wang, Jie; Tinder, Teresa T; Tonapi, Sonal; Duncan, Janet; Hornung, Tassilo; Hunter, Andrew; Miglarese, Mark R; Schorr, Joachim; Halbert, David D; Quackenbush, John; Poste, George; Berry, Donald A; Mayer, Günter; Famulok, Michael; Spetzler, David

    2017-02-20

    Technologies capable of characterizing the full breadth of cellular systems need to be able to measure millions of proteins, isoforms, and complexes simultaneously. We describe an approach that fulfils this criterion: Adaptive Dynamic Artificial Poly-ligand Targeting (ADAPT). ADAPT employs an enriched library of single-stranded oligodeoxynucleotides (ssODNs) to profile complex biological samples, thus achieving an unprecedented coverage of system-wide, native biomolecules. We used ADAPT as a highly specific profiling tool that distinguishes women with or without breast cancer based on circulating exosomes in their blood. To develop ADAPT, we enriched a library of ~10 11 ssODNs for those associating with exosomes from breast cancer patients or controls. The resulting 10 6 enriched ssODNs were then profiled against plasma from independent groups of healthy and breast cancer-positive women. ssODN-mediated affinity purification and mass spectrometry identified low-abundance exosome-associated proteins and protein complexes, some with known significance in both normal homeostasis and disease. Sequencing of the recovered ssODNs provided quantitative measures that were used to build highly accurate multi-analyte signatures for patient classification. Probing plasma from 500 subjects with a smaller subset of 2000 resynthesized ssODNs stratified healthy, breast biopsy-negative, and -positive women. An AUC of 0.73 was obtained when comparing healthy donors with biopsy-positive patients.

  4. [Systemic inflammatory profile of smokers with and without COPD].

    Science.gov (United States)

    Mosrane, Y; Bougrida, M; Alloui, A S; Martani, M; Rouabah, L; Bourahli, M K; Mehdioui, H; Ben Saad, H

    2017-09-01

    Studies comparing the systemic inflammatory profiles of smokers with and without COPD present discordant findings. To compare the systemic inflammatory profile of smokers with and without COPD. This is a cross-sectional comparative study. Two groups of active smokers of more than 10 pack-years were included: 56 consecutives stable COPD (postbronchodilator FEV 1 /FVCnon-COPD (postbronchodilator FEV 1 /FVC≥0.70). Smoking and clinical, anthropometric and spirometric data were noted. The following blood biomarkers were identified: leukocytes, hemoglobin, tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR). According to the levels (normal/abnormal) of these markers, two groups of smokers were formed. Quantitative and qualitative data were expressed, respectively, as means±SD and percentages. Compared to the non-COPD group, the COPD group was older (56±12 vs. 65±8 years) and had a higher smoking consumption (30±18 vs. 52±31 pack-years). Compared to the non-COPD group, the COPD group had higher values of CRP (2.06±1.24 vs. 11.32±11.03mg/L), of ESR (9.59±8.29 vs. 15.96±11.56), of IL-6 (9.28±4.69 vs. 20.27±5.31ng/L) and of TNF-α (18.38±7.98ng/L vs. 8.62±3.72ng/L). Compared to the non-COPD group, the COPD group included higher percentages of smokers with elevated CRP (0 % vs. 32 %), with leukocytosis (6 % vs. 16 %), with higher levels of IL-6 (81 % vs. 98 %) or TNF-α (91 % vs. 100 %). Smokers with COPD, compared to smokers free from COPD, have a marked systemic inflammation. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  5. Differences in sheep and goats milk fatty acid profile between conventional and organic farming systems.

    Science.gov (United States)

    Tsiplakou, Eleni; Kotrotsios, Vaios; Hadjigeorgiou, Ioannis; Zervas, George

    2010-08-01

    The objective of this study was to investigate whether there is a difference in chemical composition and particularly in fatty acid (FA) profile, with emphasis on cis-9, trans-11 CLA, of milk obtained from conventional and organic dairy sheep and goats farms under the farming conditions practiced in Greece. Four dairy sheep and four dairy goat farms, representing common conventional production systems and another four dairy sheep and four dairy goat farms, organically certified, representing organic production and feeding systems were selected from all over Greece. One hundred and sixty two individual milk samples were collected from those farms in January-February 2009, about three months after parturition. The milk samples were analyzed for their main chemical constituents and their FA profile. The results showed that the production system affected milk chemical composition: in particular fat content was lower in the organic sheep and goats milk compared with the corresponding conventional. Milk from organic sheep had higher content in MUFA, PUFA, alpha-LNA, cis-9, trans-11 CLA, and omega-3 FA, whereas in milk from organic goats alpha-LNA and omega-3 FA content was higher than that in conventional one. These differences are, mainly, attributed to different feeding practices used by the two production systems. The results of this study show that the organic milk produced under the farming conditions practiced in Greece has higher nutritional value, due to its FA profile, compared with the respective conventional milk.

  6. Design of an O-mode frequency modulated reflectometry system for the measurement of Alborz Tokamak plasma density profile

    Energy Technology Data Exchange (ETDEWEB)

    Koohestani, Saeideh [Department of Energy Engineering and physics, Amirkabir University of Technology, Tehran, 15875-4413, Islamic Republic of Iran (Iran, Islamic Republic of); Amrollahi, Reza, E-mail: amrollahi@aut.ac.ir [Department of Energy Engineering and physics, Amirkabir University of Technology, Tehran, 15875-4413, Islamic Republic of Iran (Iran, Islamic Republic of); Moradi, Gholamreza [Department of Electrical Engineering, Amirkabir University of Technology, Tehran, 15875-4413, Islamic Republic of Iran (Iran, Islamic Republic of)

    2016-12-15

    Reflectometry is a common method for plasma diagnostic, in which microwaves are launched into the plasma and reflected at the critical surfaces. Comparing the reflected microwave signals with the launched waves would give rise to the plasma density profiles. In the present study, an ordinary mode (O-mode) frequency modulation (FM) reflectometry system has been designed for the electron density profile measurement of the Alborz Tokamak plasma. This system has been considered to operate at K-band (18–26.5 GHz) frequency range and scan the frequency band between 18 to 26 GHz in 40 μS. The density profile from major radius r = 47.9–51.55 cm can be measured in Alborz Tokamak plasma. Based on the Alborz Tokamak operational conditions, the characteristic frequencies, and some dimensional limitations, all parts of reflectometer have been designed so that an appropriate efficiency with minimum attenuation, especially in transmitting/receiving system would be achieved. A dual antenna and an oversized waveguide of X-band (8–12 GHz) for transmitting and receiving purposes and a balanced detector for absolute phase determination have been utilized. The details of the Alborz Tokamak FM reflectometry components focusing on the antenna and waveguide design and mounting are described in this paper. Additionally, the procedure of plasma profile reconstruction using the system output signal is discussed. This system uses signal phase shift to determine the position of the cutoff layer.

  7. Electron density profile reconstruction by maximum entropy method with multichannel HCN laser interferometer system on SPAC VII

    International Nuclear Information System (INIS)

    Kubo, S.; Narihara, K.; Tomita, Y.; Hasegawa, M.; Tsuzuki, T.; Mohri, A.

    1988-01-01

    A multichannel HCN laser interferometer system has been developed to investigate the plasma electron confinement properties in SPAC VII device. Maximum entropy method is applied to reconstruct the electron density profile from measured line integrated data. Particle diffusion coefficient in the peripheral region of the REB ring core spherator was obtained from the evolution of the density profile. (author)

  8. BEAP profiles as rapid test system for status analysis and early detection of process incidents in biogas plants.

    Science.gov (United States)

    Refai, Sarah; Berger, Stefanie; Wassmann, Kati; Hecht, Melanie; Dickhaus, Thomas; Deppenmeier, Uwe

    2017-03-01

    A method was developed to quantify the performance of microorganisms involved in different digestion levels in biogas plants. The test system was based on the addition of butyrate (BCON), ethanol (ECON), acetate (ACON) or propionate (PCON) to biogas sludge samples and the subsequent analysis of CH 4 formation in comparison to control samples. The combination of the four values was referred to as BEAP profile. Determination of BEAP profiles enabled rapid testing of a biogas plant's metabolic state within 24 h and an accurate mapping of all degradation levels in a lab-scale experimental setup. Furthermore, it was possible to distinguish between specific BEAP profiles for standard biogas plants and for biogas reactors with process incidents (beginning of NH 4 + -N inhibition, start of acidification, insufficient hydrolysis and potential mycotoxin effects). Finally, BEAP profiles also functioned as a warning system for the early prediction of critical NH 4 + -N concentrations leading to a drop of CH 4 formation.

  9. From profile to sawtooth control: developing feedback control using ECRH/ECCD systems on the TCV tokamak

    International Nuclear Information System (INIS)

    Paley, J I; Felici, F; Coda, S; Goodman, T P

    2009-01-01

    Real time control of heating systems is essential to maximize plasma performance and avoid or neutralize instabilities under changing plasma conditions. Several feedback control algorithms have been developed on the Tokamak a Configuration Variable (TCV) tokamak that use the electron cyclotron (ECRH/ECCD) system to control a wide range of plasma properties, including the plasma current, shape, profiles as well as the sawtooth instability. Controllers have been developed to obtain sawteeth of a pre-determined period, to maximize the sawtooth period using an extremum seeking control algorithm and finally to provide simultaneous control of the plasma emission profile peak and width using multiple independent EC actuators.

  10. Direct radioimmunoassay of proinsulin and insulin in human plasma by the chromatographic technique

    Energy Technology Data Exchange (ETDEWEB)

    Megahed, Y M; Abdel-Wahab, M F; El-Shawarbie, K; Sadek, S; Amer, M S [Atomic Energy Establishment, Cairo (Egypt). Radioisotope Department; Ain Shams Univ., Cairo (Egypt). Faculty of Medicine)

    1976-04-01

    Specific method for direct radioimmunoassay of IRP and IRI separately in human plasma has been described. The method is used for extraction of total insulin and separation of IRP from IRI by paper chromatography to be assayed separately. The separation of the two components is identified and confirmed by column chromatography, paper chromatography and ultraviolet spectral analysis in comparison with the standard compounds. 134 plasma samples of different cases were investigated for the determination of IRI, IRP and IRT. Out of these 39 were normals, 16 normal obes, 21 juvinil diabetes, 18 overt adult diabetes, 10 recent adult diabetes, 12 hypothyroidism and 18 bilharzial hepatosplenomegaly. They were used to evaluate the test levels in comparison with blood sugar concentration.

  11. Temperature Profile in Fuel and Tie-Tubes for Nuclear Thermal Propulsion Systems

    Energy Technology Data Exchange (ETDEWEB)

    Vishal Patel

    2015-02-01

    A finite element method to calculate temperature profiles in heterogeneous geometries of tie-tube moderated LEU nuclear thermal propulsion systems and HEU designs with tie-tubes is developed and implemented in MATLAB. This new method is compared to previous methods to demonstrate shortcomings in those methods. Typical methods to analyze peak fuel centerline temperature in hexagonal geometries rely on spatial homogenization to derive an analytical expression. These methods are not applicable to cores with tie-tube elements because conduction to tie-tubes cannot be accurately modeled with the homogenized models. The fuel centerline temperature directly impacts safety and performance so it must be predicted carefully. The temperature profile in tie-tubes is also important when high temperatures are expected in the fuel because conduction to the tie-tubes may cause melting in tie-tubes, which may set maximum allowable performance. Estimations of maximum tie-tube temperature can be found from equivalent tube methods, however this method tends to be approximate and overly conservative. A finite element model of heat conduction on a unit cell can model spatial dependence and non-linear conductivity for fuel and tie-tube systems allowing for higher design fidelity of Nuclear Thermal Propulsion.

  12. The actin-binding protein profilin 2 is a novel regulator of iron homeostasis.

    Science.gov (United States)

    Luscieti, Sara; Galy, Bruno; Gutierrez, Lucia; Reinke, Michael; Couso, Jorge; Shvartsman, Maya; Di Pascale, Antonio; Witke, Walter; Hentze, Matthias W; Pilo Boyl, Pietro; Sanchez, Mayka

    2017-10-26

    Cellular iron homeostasis is controlled by the iron regulatory proteins (IRPs) 1 and 2 that bind cis -regulatory iron-responsive elements (IRE) on target messenger RNAs (mRNA). We identified profilin 2 ( Pfn2 ) mRNA, which encodes an actin-binding protein involved in endocytosis and neurotransmitter release, as a novel IRP-interacting transcript, and studied its role in iron metabolism. A combination of electrophoretic mobility shift assay experiments and bioinformatic analyses led to the identification of an atypical and conserved IRE in the 3' untranslated region of Pfn2 mRNA. Pfn2 mRNA levels were significantly reduced in duodenal samples from mice with intestinal IRP ablation, suggesting that IRPs exert a positive effect on Pfn2 mRNA expression in vivo. Overexpression of Pfn2 in HeLa and Hepa1-6 cells reduced their metabolically active iron pool. Importantly, Pfn2-deficient mice showed iron accumulation in discrete areas of the brain (olfactory bulb, hippocampus, and midbrain) and reduction of the hepatic iron store without anemia. Despite low liver iron levels, hepatic hepcidin expression remained high, likely because of compensatory activation of hepcidin by mild inflammation. Splenic ferroportin was increased probably to sustain hematopoiesis. Overall, our results indicate that Pfn2 expression is controlled by the IRPs in vivo and that Pfn2 contributes to maintaining iron homeostasis in cell lines and mice. © 2017 by The American Society of Hematology.

  13. Zinc deficiency-induced iron accumulation, a consequence of alterations in iron regulatory protein-binding activity, iron transporters, and iron storage proteins.

    Science.gov (United States)

    Niles, Brad J; Clegg, Michael S; Hanna, Lynn A; Chou, Susan S; Momma, Tony Y; Hong, Heeok; Keen, Carl L

    2008-02-22

    One consequence of zinc deficiency is an elevation in cell and tissue iron concentrations. To examine the mechanism(s) underlying this phenomenon, Swiss 3T3 cells were cultured in zinc-deficient (D, 0.5 microM zinc), zinc-supplemented (S, 50 microM zinc), or control (C, 4 microM zinc) media. After 24 h of culture, cells in the D group were characterized by a 50% decrease in intracellular zinc and a 35% increase in intracellular iron relative to cells in the S and C groups. The increase in cellular iron was associated with increased transferrin receptor 1 protein and mRNA levels and increased ferritin light chain expression. The divalent metal transporter 1(+)iron-responsive element isoform mRNA was decreased during zinc deficiency-induced iron accumulation. Examination of zinc-deficient cells revealed increased binding of iron regulatory protein 2 (IRP2) and decreased binding of IRP1 to a consensus iron-responsive element. The increased IRP2-binding activity in zinc-deficient cells coincided with an increased level of IRP2 protein. The accumulation of IRP2 protein was independent of zinc deficiency-induced intracellular nitric oxide production but was attenuated by the addition of the antioxidant N-acetylcysteine or ascorbate to the D medium. These data support the concept that zinc deficiency can result in alterations in iron transporter, storage, and regulatory proteins, which facilitate iron accumulation.

  14. From the SAIN,LIM system to the SENS algorithm: a review of a French approach of nutrient profiling.

    Science.gov (United States)

    Tharrey, Marion; Maillot, Matthieu; Azaïs-Braesco, Véronique; Darmon, Nicole

    2017-08-01

    Nutrient profiling aims to classify or rank foods according to their nutritional composition to assist policies aimed at improving the nutritional quality of foods and diets. The present paper reviews a French approach of nutrient profiling by describing the SAIN,LIM system and its evolution from its early draft to the simplified nutrition labelling system (SENS) algorithm. Considered in 2010 by WHO as the 'French model' of nutrient profiling, SAIN,LIM classifies foods into four classes based on two scores: a nutrient density score (NDS) called SAIN and a score of nutrients to limit called LIM, and one threshold on each score. The system was first developed by the French Food Standard Agency in 2008 in response to the European regulation on nutrition and health claims (European Commission (EC) 1924/2006) to determine foods that may be eligible for bearing claims. Recently, the European regulation (EC 1169/2011) on the provision of food information to consumers allowed simplified nutrition labelling to facilitate consumer information and help them make fully informed choices. In that context, the SAIN,LIM was adapted to obtain the SENS algorithm, a system able to rank foods for simplified nutrition labelling. The implementation of the algorithm followed a step-by-step, systematic, transparent and logical process where shortcomings of the SAIN,LIM were addressed by integrating specificities of food categories in the SENS, reducing the number of nutrients, ordering the four classes and introducing European reference intakes. Through the French example, this review shows how an existing nutrient profiling system can be specifically adapted to support public health nutrition policies.

  15. Microbial Community Profiles in Wastewaters from Onsite Wastewater Treatment Systems Technology.

    Directory of Open Access Journals (Sweden)

    Łukasz Jałowiecki

    Full Text Available The aim of the study was to determine the potential of community-level physiological profiles (CLPPs methodology as an assay for characterization of the metabolic diversity of wastewater samples and to link the metabolic diversity patterns to efficiency of select onsite biological wastewater facilities. Metabolic fingerprints obtained from the selected samples were used to understand functional diversity implied by the carbon substrate shifts. Three different biological facilities of onsite wastewater treatment were evaluated: fixed bed reactor (technology A, trickling filter/biofilter system (technology B, and aerated filter system (the fluidized bed reactor, technology C. High similarities of the microbial community functional structures were found among the samples from the three onsite wastewater treatment plants (WWTPs, as shown by the diversity indices. Principal components analysis (PCA showed that the diversity and CLPPs of microbial communities depended on the working efficiency of the wastewater treatment technologies. This study provided an overall picture of microbial community functional structures of investigated samples in WWTPs and discerned the linkages between microbial communities and technologies of onsite WWTPs used. The results obtained confirmed that metabolic profiles could be used to monitor treatment processes as valuable biological indicators of onsite wastewater treatment technologies efficiency. This is the first step toward understanding relations of technology types with microbial community patterns in raw and treated wastewaters.

  16. New Mexico Look for the STARS--AIM HIGH: QRS Profile. The Child Care Quality Rating System (QRS) Assessment

    Science.gov (United States)

    Child Trends, 2010

    2010-01-01

    This paper presents a profile of New Mexico's Look for the STARS--AIM HIGH prepared as part of the Child Care Quality Rating System (QRS) Assessment Study. The profile consists of several sections and their corresponding descriptions including: (1) Program Information; (2) Rating Details; (3) Quality Indicators for Center-Based Programs; (4)…

  17. Fully automated laser ray tracing system to measure changes in the crystalline lens GRIN profile.

    Science.gov (United States)

    Qiu, Chen; Maceo Heilman, Bianca; Kaipio, Jari; Donaldson, Paul; Vaghefi, Ehsan

    2017-11-01

    Measuring the lens gradient refractive index (GRIN) accurately and reliably has proven an extremely challenging technical problem. A fully automated laser ray tracing (LRT) system was built to address this issue. The LRT system captures images of multiple laser projections before and after traversing through an ex vivo lens. These LRT images, combined with accurate measurements of the lens geometry, are used to calculate the lens GRIN profile. Mathematically, this is an ill-conditioned problem; hence, it is essential to apply biologically relevant constraints to produce a feasible solution. The lens GRIN measurements were compared with previously published data. Our GRIN retrieval algorithm produces fast and accurate measurements of the lens GRIN profile. Experiments to study the optics of physiologically perturbed lenses are the future direction of this research.

  18. Cytokines in systemic lupus erythematosus: far beyond Th1/Th2 dualism lupus: cytokine profiles.

    Science.gov (United States)

    Guimarães, Poliana Macedo; Scavuzzi, Bruna Miglioranza; Stadtlober, Nicole Perugini; Franchi Santos, Lorena Flor da Rosa; Lozovoy, Marcell Alysson Batisti; Iriyoda, Tatiana Mayumi Veiga; Costa, Neide Tomimura; Reiche, Edna Maria Vissoci; Maes, Michael; Dichi, Isaias; Simão, Andréa Name Colado

    2017-10-01

    The aims of this study were to delineate cytokine profiles of systemic lupus erythematosus (SLE), construct prediction models for diagnosis and disease activity using those profiles, and to examine the associations between TNFB Ncol polymorphism, body mass index (BMI) and vitamin D levels with cytokine levels. Two hundred SLE patients and 196 healthy controls participated in this case-control study. Plasma cytokines levels of tumor necrosis factor (TNF)-α, interferon (IFN)-γ, interleukin (IL)-1β, IL- 4, IL-6, IL-10, IL-12 and IL-17 were measured and cytokines profiles were computed. IL-6, IL-12, IL-17, IFN-γ and IL-10 levels were significantly higher in SLE, while IL-4 was lower in SLE. The Th1/Th2 and Th1+Th17/Th2 profiles were significantly higher in SLE than in healthy controls, whereas there were no significant differences in the proinflammatory cytokine profile (TNFα+IL-6+IL-1β). In total, 90.4% of all subjects were correctly classified using Th1+Th17 profile and IL-10 (positively associated) and IL-4 (negatively associated) as predictor variables (sensitivity=66.7% and specificity=96.9%). In all, 20.9% of the variance in the SLE Disease Activity Index was predicted by the Th1+Th17/Th2 ratio, IL-10 and BMI (all positively) and proinflammatory profile (inversely associated). B1/B1 genotype is accompanied by increased IL-17 and Th17/Th2 ratio, while B1/B2 genotype is accompanied by higher IL-4 and IFNγ values. 25-OH vitamin D was inversely associated with IFN-γ levels. SLE is accompanied by Th1, Th17 and Treg profile and lowered IL-4 production. Lowered vitamin D levels and B1/B1 genotype, but not BMI, contribute to changes in cytokines profiles. Future treatments should target Th1, Th2 and Th17 profiles rather than inflammatory cytokines.

  19. Assessing the influence of the temporal resolution of electrical load and PV generation profiles on self-consumption and sizing of PV-battery systems

    International Nuclear Information System (INIS)

    Beck, T.; Kondziella, H.; Huard, G.; Bruckner, T.

    2016-01-01

    Highlights: • MILP optimization model for operation and investment of PV-battery systems. • Use of high resolution (10 s) electrical household load and PV generation profiles. • Analysis of influence of temporal resolution on self-consumption and optimal sizing. • Electrical load profile characteristics influence required temporal resolution. - Abstract: The interest in self-consumption of electricity generated by rooftop photovoltaic systems has grown in recent years, fueled by decreasing levelized costs of electricity and feed-in tariffs as well as increasing end customer electricity prices in the residential sector. This also fostered research on grid-connected PV-battery storage systems, which are a promising technology to increase self-consumption. In this paper a mixed-integer linear optimization model of a PV-battery system that minimizes the total discounted operating and investment costs is developed. The model is employed to study the effect of the temporal resolution of electrical load and PV generation profiles on the rate of self-consumption and the optimal sizing of PV and PV-battery systems. In contrast to previous studies high resolution (10 s) measured input data for both PV generation and electrical load profiles is used for the analysis. The data was obtained by smart meter measurements in 25 different households in Germany. It is shown that the temporal resolution of load profiles is more critical for the accuracy of the determination of self-consumption rates than the resolution of the PV generation. For PV-systems without additional storage accurate results can be obtained by using 15 min solar irradiation data. The required accuracy for the electrical load profiles depends strongly on the load profile characteristics. While good results can be obtained with 60 s for all electrical load profiles, 15 min data can still be sufficient for load profiles that do not exhibit most of their electricity consumption at power levels above 2 k

  20. Analytical calculations of the rotational transform angles in the torsatron systems with different plasma pressure profiles

    International Nuclear Information System (INIS)

    Kuznetsov, Yu.K.; Pinos, I.B.; Tyupa, V.I.

    1999-01-01

    With formulas for averaging over magnetic surfaces general analytical expressions are here deduced to determine the rotational transform angles in stellarator systems having different plasma pressure profiles

  1. Phosphorus distribution in sandy soil profile under drip irrigation system

    International Nuclear Information System (INIS)

    El-Gendy, R.W.; Rizk, M.A.; Abd El Moniem, M.; Abdel-Aziz, H.A.; Fahmi, A.E.

    2009-01-01

    This work aims at to studying the impact of irrigation water applied using drip irrigation system in sandy soil with snap bean on phosphorus distribution. This experiment was carried out in soils and water research department farm, nuclear research center, atomic energy authority, cairo, Egypt. Snap bean was cultivated in sandy soil and irrigated with 50,37.5 and 25 cm water in three water treatments represented 100, 75 and 50% ETc. Phosphorus distribution and direction of soil water movement had been detected in three sites on the dripper line (S1,S2 and S3 at 0,12.5 and 25 cm distance from dripper). Phosphorus fertilizer (super phosphate, 15.5% P 2 O 5 in rate 300 kg/fed)was added before cultivation. Neutron probe was used to detect the water distribution and movement at the three site along soil profile. Soil samples were collected before p-addition, at end developing, mid, and late growth stages to determine residual available phosphorus. The obtained data showed that using 50 cm water for irrigation caused an increase in P-concentration till 75 cm depth in the three sites of 100% etc treatment, and covered P-requirements of snap bean for all growth stages. As for 37.5 and 25 cm irrigation water cannot cover all growth stages for P-requirements of snap bean. It could be concluded that applied irrigation water could drive the residual P-levels till 75 cm depth in the three sites. Yield of the crop had been taken as an indicator as an indicator profile. Yield showed good response according to water quantities and P-transportation within the soil profile

  2. Fluoride-Salt-Cooled High-Temperature Reactor (FHR) for Power and Process Heat

    Energy Technology Data Exchange (ETDEWEB)

    Forsberg, Charles [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States); Hu, Lin-wen [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States); Peterson, Per [Univ. of California, Berkeley, CA (United States); Sridharan, Kumar [Univ. of Wisconsin, Madison, WI (United States)

    2015-01-21

    In 2011 the U.S. Department of Energy through its Nuclear Energy University Program (NEUP) awarded a 3- year integrated research project (IRP) to the Massachusetts Institute of Technology (MIT) and its partners at the University of California at Berkeley (UCB) and the University of Wisconsin at Madison (UW). The IRP included Westinghouse Electric Company and an advisory panel chaired by Regis Matzie that provided advice as the project progressed. The first sentence of the proposal stated the goals: The objective of this Integrated Research Project (IRP) is to develop a path forward to a commercially viable salt-cooled solid-fuel high-temperature reactor with superior economic, safety, waste, nonproliferation, and physical security characteristics compared to light-water reactors. This report summarizes major results of this research.

  3. Fluoride-Salt-Cooled High-Temperature Reactor (FHR) for Power and Process Heat

    International Nuclear Information System (INIS)

    Forsberg, Charles; Hu, Lin-wen; Peterson, Per; Sridharan, Kumar

    2015-01-01

    In 2011 the U.S. Department of Energy through its Nuclear Energy University Program (NEUP) awarded a 3- year integrated research project (IRP) to the Massachusetts Institute of Technology (MIT) and its partners at the University of California at Berkeley (UCB) and the University of Wisconsin at Madison (UW). The IRP included Westinghouse Electric Company and an advisory panel chaired by Regis Matzie that provided advice as the project progressed. The first sentence of the proposal stated the goals: The objective of this Integrated Research Project (IRP) is to develop a path forward to a commercially viable salt-cooled solid-fuel high-temperature reactor with superior economic, safety, waste, nonproliferation, and physical security characteristics compared to light-water reactors. This report summarizes major results of this research.

  4. A renewables-based South African energy system?

    CSIR Research Space (South Africa)

    Bischof-Niemz, T

    2015-12-01

    Full Text Available in electricity mix from 75 to 50% by 2025 That's a reduction by 140 TWh/yr of nuclear power generation, which is the same amount of energy produced by 10 Koebergs This energy will be replaced by renewables This emphasises again the recently achieved cost...-competitiveness of renewableshttp://www.world-nuclear-news.org/NP-French- energy-transition-bill-adopted-2307155.html 8Agenda International context Renewables in South Africa Extreme renewables scenarios 9Integrated Resource Plan 2010 (IRP 2010): Plan of the power generation mix...

  5. Nondestructive strain depth profiling with high energy X-ray diffraction: System capabilities and limitations

    Science.gov (United States)

    Zhang, Zhan; Wendt, Scott; Cosentino, Nicholas; Bond, Leonard J.

    2018-04-01

    Limited by photon energy, and penetration capability, traditional X-ray diffraction (XRD) strain measurements are only capable of achieving a few microns depth due to the use of copper (Cu Kα1) or molybdenum (Mo Kα1) characteristic radiation. For deeper strain depth profiling, destructive methods are commonly necessary to access layers of interest by removing material. To investigate deeper depth profiles nondestructively, a laboratory bench-top high-energy X-ray diffraction (HEXRD) system was previously developed. This HEXRD method uses an industrial 320 kVp X-Ray tube and the Kα1 characteristic peak of tungsten, to produces a higher intensity X-ray beam which enables depth profiling measurement of lattice strain. An aluminum sample was investigated with deformation/load provided using a bending rig. It was shown that the HEXRD method is capable of strain depth profiling to 2.5 mm. The method was validated using an aluminum sample where both the HEXRD method and the traditional X-ray diffraction method gave data compared with that obtained using destructive etching layer removal, performed by a commercial provider. The results demonstrate comparable accuracy up to 0.8 mm depth. Nevertheless, higher attenuation capabilities in heavier metals limit the applications in other materials. Simulations predict that HEXRD works for steel and nickel in material up to 200 µm, but experiment results indicate that the HEXRD strain profile is not practical for steel and nickel material, and the measured diffraction signals are undetectable when compared to the noise.

  6. Surface profile measurement by using the integrated Linnik WLSI and confocal microscope system

    Science.gov (United States)

    Wang, Wei-Chung; Shen, Ming-Hsing; Hwang, Chi-Hung; Yu, Yun-Ting; Wang, Tzu-Fong

    2017-06-01

    The white-light scanning interferometer (WLSI) and confocal microscope (CM) are the two major optical inspection systems for measuring three-dimensional (3D) surface profile (SP) of micro specimens. Nevertheless, in practical applications, WLSI is more suitable for measuring smooth and low-slope surfaces. On the other hand, CM is more suitable for measuring uneven-reflective and low-reflective surfaces. As for aspect of surface profiles to be measured, the characteristics of WLSI and CM are also different. WLSI is generally used in semiconductor industry while CM is more popular in printed circuit board industry. In this paper, a self-assembled multi-function optical system was integrated to perform Linnik white-light scanning interferometer (Linnik WLSI) and CM. A connecting part composed of tubes, lenses and interferometer was used to conjunct finite and infinite optical systems for Linnik WLSI and CM in the self-assembled optical system. By adopting the flexibility of tubes and lenses, switching to perform two different optical measurements can be easily achieved. Furthermore, based on the shape from focus method with energy of Laplacian filter, the CM was developed to enhance the on focal information of each pixel so that the CM can provide all-in-focus image for performing the 3D SP measurement and analysis simultaneously. As for Linnik WLSI, eleven-step phase shifting algorithm was used to analyze vertical scanning signals and determine the 3D SP.

  7. Urban logistics profile – Yogyakarta city, Indonesia

    Directory of Open Access Journals (Sweden)

    Maria Sri Asih Anna

    2018-01-01

    Full Text Available In recent years, more rural areas are becoming urban areas accompanied by escalation of logistics activities. Unlike passenger transport, the planning, policy and control of freight transport in developing countries have not been integrated into a reliable and efficient logistics system. Therefore, generating city logistics profile is necessary in order to support the planning of urban logistics system. This study aims to establish a logistics profile of Yogyakarta city, Indonesia, by dividing urban zones into several homogeneous groups, judging from several aspects, including city area features, product characteristics and agents/delivery profile. Logistics profile variables were calculated based on administrative boundaries, resulting in 45 areas to be investigated. Profiles were matched in groups of homogeneous stores (A, large commercial stores (C and residential areas with local trade (D,with one overlapping profile, i.e. profile A and profile D, in some locations in the middle of the city.

  8. [MMPI-2 profiles in groups of systemic autoimmune disease - rheumatoid arthritis and systemic lupus erythematosus - patients].

    Science.gov (United States)

    Csókási, Krisztina; Hargitai, Rita; Járai, Róbert; Nagy, László; Czirják, László; Kiss, Enikö Csilla

    2015-01-01

    Systemic autoimmune diseases like rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) are characterized by the alteration of immunological response, which can damage many organs and systems and result in a wide variety of clinical presentations. In addition to physical symptoms, psychiatric disorders are also common to many autoimmune diseases. Anxiety, depression, psychosis and cognitive deficits have the highest prevalence. The aim of this study was to display the degree of psychopathological symptoms in patients with RA and SLE. Female inpatients with RA (N=68) and SLE (N=78) were recruited from the Rheumatology and Immunology Clinic of the University of Pecs and were asked to complete the Minnesota Multiphasic Personality Inventory-2 (MMPI-2) and a short demografical form. The clinical personality profiles of the patient groups were explored and compared with each other. High scores (above 64T) were detected on the Hypochondriasis (Hs), Depression (D) and Hysteria (Hy) scales in both groups. Besides, the participants performed elevated scores on the Masculinity-Feminity (Mf), Psychasthenia (Pt) and Social Introversion (Si) clinical scales. They scored in the elevated range on the Physical Malfunctioning, Subjective Depression, Lassitude-Malaise and Somatic Complaints subscales of the neurotic triad. No significant difference was found on the ten clinical scales between the SLE and RA patients. Characteristics of MMPI-2 profiles in SLE and RA patients seem to be the consequence of the disease and a common feature of chronic conditions. High scores on the neurotic triad scales may reflect the comorbid psychiatric disorders and the somatic symptoms alike, so further investigations with the revised Hungarian MMPI-2 are needed.

  9. Department of the Army Installation Restoration Program

    International Nuclear Information System (INIS)

    Anderson, A.W.

    1988-01-01

    The Army's Installation Restoration Program (IRP) was established in 1975 in response to regulatory action at several installations where past disposal practices had caused contamination of streams and groundwater. The need to decontaminate excess Army-owned real estate also was considered in early IRP activities. A variety of site types have been discovered on Army installations. The major site types evaluated to date include: contaminated soil areas, landfills, lagoons, buildings, burning grounds, sumps, pits, storage tanks, sewage treatment plants, storage pads, industrial wastewater treatment plants, and salvage yards. Twenty Army installations have been proposed for or listed on the National Priorities List (NPL). The need for taking action at hazardous waste sites, however, is based on threats they pose to human health, welfare or the environment. Sites do not have to be on the SPL in order to be cleaned up through IRP activities. All of the sites that caused Army installations to be proposed for the NPL are being evaluated and cleaned up. In addition, all Army properties have been or will be assessed and where needed they will be addressed by the IRP

  10. EDNA-An expert software system for comparison and evaluation of DNA profiles in forensic casework

    DEFF Research Database (Denmark)

    Haldemann, B.; Dornseifer, S.; Heylen, T.

    2015-01-01

    eDNA is an expert software system for DNA profile comparison, match interpretation and automated report generation in forensic DNA casework. Process automation and intelligent graphical representation maximise reliability of DNA evidence, while facilitating and accelerating the work of DNA experts....

  11. Hydrogeologic controls on saturation profiles in heat-pipe-like hydrothermal systems: numerical study

    Science.gov (United States)

    Pervin, Mollika; Ghergut, Iulia; Graf, Thomas; Peche, Aaron

    2016-04-01

    Most geothermal reservoirs are of the liquid-dominated type, and their unexploited-state pressure profile approximately follows the hydrostatic gradient. In very hot liquid-dominated systems, temperature typically follows a boiling-point-for-depth (BPD) relationship. By contrast, vapor-dominated systems exhibit (in their unexploited state) surprisingly small vertical gradients of temperature and pressure, such that a constantly high temperature is encountered over a large vertical thickness, while their pressure approximately follows vapour pressure, pvap(T°). This implies that (Pruess 1985, Truesdell and White 1973): (i) for a vapor-dominated reservoir to exist, it must be sealed laterally - otherwise it would be flooded by neighboring groundwaters with hydrostatic p profile, and (ii) liquid water should somehow be present in the whole system - otherwise p values would not be constrained by the pvap(T°) relationship for water. Historically, one of the most puzzling aspects of vapor-dominated systems was the large amount of heat flowing upwards, while vertical T° gradients remained negligible. This mechanism was deemed as 'heat pipe'(HP) (Eastman 1968): In the central zone of a vapor-dominated system, both vapor and liquid are mobile; vapor flows upwards, condenses at shallower depth, and the liquid condensate flows downwards. Due to the large amount of latent enthalpy released in vapor condensation, the vapor-liquid counter-flow can generate large rates of heat flow with negligible net mass transport (Pruess 1985). In order to be able to exploit two-phase (including vapor-dominated) reservoirs in a sustainable manner, one first needs to understand the conditions under which a two-phase (or a vapor-dominated) system has evolved naturally, and which have led to its present (quasi-) steady undisturbed state. Past studies have found that HP can exist in two distinct states, corresponding to liquid-dominated and vapor-dominated p profiles, respectively. Within this

  12. Beam profile monitors in the NLCTA

    International Nuclear Information System (INIS)

    Nantista, C.; Adolphsen, C.; Brown, R.L.; Fuller, R.; Rifkin, J.

    1997-05-01

    The transverse current profile in the Next Linear Collider Test Accelerator (NLCTA) electron beam can be monitored at several locations along the beam line by means of profile monitors. These consist of insertable phosphor screens, light collection and transport systems, CID cameras, a frame-grabber, and PC and VAX based image analysis software. In addition to their usefulness in tuning and steering the accelerator, the profile monitors are utilized for emittance measurement. A description of these systems and their performance is presented

  13. Association of High-Resolution Manometry Metrics with the Symptoms of Achalasia and the Symptomatic Outcomes of Peroral Esophageal Myotomy.

    Science.gov (United States)

    Tang, Yurong; Xie, Chen; Wang, Meifeng; Jiang, Liuqin; Shi, Ruihua; Lin, Lin

    2015-01-01

    High-resolution manometry (HRM) has improved the accuracy of manometry in detecting achalasia and has helped distinguish between clinically relevant subtypes. This study investigated whether HRM metrics correlate with the achalasia symptoms and symptomatic outcomes of peroral esophageal myotomy (POEM). Of the 30 patients who were enrolled, 25 were treated with POEM, 12 of who underwent HRM after 3 months. All the patients completed the Eckardt score questionnaires, and those who underwent POEM were followed up for about 6 months. Pearson correlation was used to assess the relationship between the HRM metrics and symptoms and outcomes. The integrated relaxation pressure (IRP) score positively correlated with the total Eckardt score, regurgitation score and weight loss score in all the patients, and with the weight loss score in type I achalasia. In 25 patients (10 patients, type I; 15 patients, type II) who underwent POEM, the total Eckardt scores and individual symptom scores significantly decreased after surgery. Changes in the Eckardt scores were similar between type I and type II. Further, the Eckardt scores and weight loss score changes were positively correlated with baseline IRP. Twelve patients (4 patients, type I; 8 patients, type II) underwent HRM again after POEM. IRP changed significantly after POEM, as did the DEP in type II. The IRP changes after POEM were positively correlated with the Eckardt score changes. IRP is correlated with the symptoms and outcomes of achalasia patients. Thus, HRM is effective for assessing the severity of achalasia and can predict the efficacy of POEM.

  14. YERSINIA PSEUDOTUBERCULOSIS, SEROGROUP O:1A, INFECTION IN TWO AMAZON PARROTS (AMAZONA AESTIVA AND AMAZONA ORATRIX) WITH HEPATIC HEMOSIDEROSIS.

    Science.gov (United States)

    Galosi, Livio; Farneti, Silvana; Rossi, Giacomo; Cork, Susan Catherine; Ferraro, Stefano; Magi, Gian Enrico; Petrini, Stefano; Valiani, Andrea; Cuteri, Vincenzo; Attili, Anna-Rita

    2015-09-01

    Necropsies were conducted on a female blue-fronted Amazon (Amazona aestiva) and a female yellow-headed Amazon (Amazona oratrix) that died after depression, ruffled feathers, diarrhea, and biliverdin in the urine. Gross and microscopic examinations revealed multifocal necrosis in the liver, spleen, lungs, kidneys, intestines, and heart caused by acute bacteremia. Yersinia pseudotuberculosis, serogroup O:1a, was isolated by culturing from the visceral lesions in the liver, intestines, and spleen. Virulence gene analysis showed the presence of the inv gene and the complete pathogenicity island: IS100, psn, yptE, irp1, irp2 ybtP-ybtQ, ybtX-ybtS, and int asnT-Int. Histopathologic findings and chemical analysis also demonstrated hepatic hemosiderosis. As has been demonstrated in other species, hemosiderosis may predispose Amazona spp. to systemic infection with Y. pseudotuberculosis after enteric disease.

  15. Treatment of Adults with Idiopathic Recurrent Pericarditis: Novel Use of Immunotherapy.

    Science.gov (United States)

    Schwier, Nicholas C; Hale, Genevieve M; Davies, Marie L

    2017-03-01

    Idiopathic recurrent pericarditis (IRP) can be challenging to treat. Even after guideline-directed first-line treatment consisting of aspirin (ASA) or a nonsteroidal antiinflammatory drug (NSAID) in combination with colchicine therapy, recurrences still occur in greater than 20% of patients. Many patients then require treatment with long-term corticosteroids, which is not a favorable option due to their short- and long-term adverse effects. Because it is theorized that the pathophysiology of IRP may possess autoimmune sequelae, the use of immunotherapy for the treatment of IRP has emerged. In this review, we describe the literature associated with immunotherapy used to treat IRP in an adult population as well as provide an overview of the safety and monitoring parameters for each agent. The most common immunotherapies used after patients have had multiple recurrences of IRP are anakinra, intravenous immunoglobulin (IVIG), and azathioprine. In most cases, these immunotherapies are adjunctive therapy, with the goal of tapering and discontinuing immunosuppressive corticosteroids. After reviewing the data, anakinra resulted in more patients discontinuing corticosteroids and prevented further recurrences of pericarditis. IVIG resulted in symptom resolution and no further recurrences in most of the patients. Azathioprine was associated with more than half of patients becoming recurrence free; however, many patients required a restart of corticosteroids due to recurrence. Clinicians should be aware of the adverse effects of immunotherapy, ranging from mild gastrointestinal events to risk of infection and serious blood dyscrasias that may require diligent monitoring. The use of immunotherapy for the treatment of adults with IRP should be restricted to patients who have multiple recurrences. Ideally, immunotherapy would be adjunctive to first-line combination therapy with ASA/NSAID plus colchicine, with the goal of tapering and discontinuing immunosuppressive

  16. Targeting Germinal Matrix Hemorrhage-Induced Overexpression of Sodium-Coupled Bicarbonate Exchanger Reduces Posthemorrhagic Hydrocephalus Formation in Neonatal Rats.

    Science.gov (United States)

    Li, Qian; Ding, Yan; Krafft, Paul; Wan, Weifeng; Yan, Feng; Wu, Guangyong; Zhang, Yixin; Zhan, Qunling; Zhang, John H

    2018-01-31

    Germinal matrix hemorrhage (GMH) is a leading cause of mortality and lifelong morbidity in preterm infants. Posthemorrhagic hydrocephalus (PHH) is a common complication of GMH. A sodium-coupled bicarbonate exchanger (NCBE) encoded by solute carrier family 4 member 10 gene is expressed on the choroid plexus basolateral membrane and may play a role in cerebrospinal fluid production and the development of PHH. Following GMH, iron degraded from hemoglobin has been linked to PHH. Choroid plexus epithelial cells also contain iron-responsive element-binding proteins (IRPs), IRP1, and IRP2 that bind to mRNA iron-responsive elements. The present study aims to resolve the following issues: (1) whether the expression of NCBE is regulated by IRPs; (2) whether NCBE regulates the formation of GMH-induced hydrocephalus; and (3) whether inhibition of NCBE reduces PHH development. GMH model was established in P7 rat pups by injecting bacterial collagenase into the right ganglionic eminence. Another group received iron trichloride injections instead of collagenase. Deferoxamine was administered intraperitoneally for 3 consecutive days after GMH/iron trichloride. Solute carrier family 4 member 10 small interfering RNA or scrambled small interfering RNA was administered by intracerebroventricular injection 24 hours before GMH and followed with an injection every 7 days over 21 days. NCBE expression increased while IRP2 expression decreased after GMH/iron trichloride. Deferoxamine ameliorated both the GMH-induced and iron trichloride-induced decrease of IRP2 and decreased NCBE expressions. Deferoxamine and solute carrier family 4 member 10 small interfering RNA improved cognitive and motor functions at 21 to 28 days post GMH and reduced cerebrospinal fluid production as well as the degree of hydrocephalus at 28 days after GMH. Targeting iron-induced overexpression of NCBE may be a translatable therapeutic strategy for the treatment of PHH following GMH. © 2018 The Authors

  17. School Health Profiles 2014: West Virginia Rankings

    Science.gov (United States)

    West Virginia Department of Education Office of Research, Accountability, and Data Governance, 2015

    2015-01-01

    The School Health Profiles (Profiles) is a system of surveys assessing school health policies and practices in states, large urban school districts, and territories. Profiles surveys are conducted biennially by education and health agencies among middle and high school principals and lead health education teachers. Profiles monitors the current…

  18. Integration of polystyrene microlenses with both convex and concave profiles in a polymer-based microfluidic system

    KAUST Repository

    Fan, Yiqiang; Li, Huawei; Foulds, Ian G.

    2013-01-01

    This paper reports a new technique of fabricating polystyrene microlenses with both convex and concave profiles that are integrated in polymer-based microfluidic system. The polystyrene microlenses, or microlens array, are fabricated using the free

  19. Time pulse profiles on a new data acquisition system for neutron time of flight diffractometer

    International Nuclear Information System (INIS)

    Venegas, R.; Baeza, L.; Navarro, G.

    1999-01-01

    A new differential acquisition system was built for a neutron diffuse scattering instrument. We analyze the time, space and velocity behavior of neutron pulse profiles, which can be obtained in a neutron diffuse scattering system of this nature, consisting of a black disc slit chopper and a circular detector bank, in order to design accurate scattering data analyzing methods. Computed direct pulse time spectra and measured spectra show satisfactory agreement. (author)

  20. Measurement system of bubbly flow using ultrasonic velocity profile monitor and video data processing unit. 2. Flow characteristics of bubbly countercurrent flow

    International Nuclear Information System (INIS)

    Aritomi, Masanori; Zhou, Shirong; Nakajima, Makoto; Takeda, Yasushi; Mori, Michitsugu.

    1997-01-01

    The authors have developed a measurement system which is composed of an ultrasonic velocity profile monitor and a video data processing unit in order to clarify its multi-dimensional flow characteristics in bubbly flows and to offer a data base to validate numerical codes for multi-dimensional two-phase flow. In this paper, the measurement system was applied for bubbly countercurrent flows in a vertical rectangular channel. At first, both bubble and water velocity profiles and void fraction profiles in the channel were investigated statistically. Next, turbulence intensity in a continuous liquid phase was defined as a standard deviation of velocity fluctuation, and the two-phase multiplier profile of turbulence intensity in the channel was clarified as a ratio of the standard deviation of flow fluctuation in a bubbly countercurrent flow to that in a water single phase flow. Finally, the distribution parameter and drift velocity used in the drift flux model for bubbly countercurrent flows were calculated from the obtained velocity profiles of both phases and void fraction profile, and were compared with the correlation proposed for bubbly countercurrent flows. (author)

  1. A Profiling System for the Assessment of Individual Needs for Rehabilitation With Hearing Aids

    Directory of Open Access Journals (Sweden)

    Wouter A. Dreschler

    2016-10-01

    Full Text Available This study focuses on the development of a profiling system to specify the needs of hearing-aid candidates. As a basis for the profile of compensation needs, we used a slightly modified version of the Amsterdam Inventory of Disability and Handicap, combined with the well-known Client-Oriented Scale of Improvement (COSI. The first questionnaire results in scores for six audiological dimensions: detection, speech in quiet, speech in noise, localization, focus or discrimination, and noise tolerance. The goal of this study was to determine whether the six dimensions derived from the disability questionnaire are appropriate to also categorize individual COSI targets. The results show a good agreement between eight audiologists in the categorization of COSI goals along the six dimensions. The results per dimension show that the dimension focus or discrimination can be regarded as superfluous. Possible additional dimensions were tinnitus and listening effort. The results indicate that it is possible to translate individual user needs (administered using COSI into more general dimensions derived from a disability questionnaire. This allows to summarize the compensation needs for individual patients in a profile of general dimensions, based on the degree of disability and the individual user needs. This profile can be used as a starting point in hearing aid selection. This approach also offers a well-structured method for the evaluation of the postfitting results.

  2. Feasability study of using the TFTR Thomson scattering system for q profile measurements

    International Nuclear Information System (INIS)

    Brizard, A.; Grewk, B.; Johnson, D.; LeBlanc, B.

    1986-01-01

    The results of a study made to determine the possibility of using the TFTR 76 channels Thomson scattering system to measure the direction of local magnetic fields in a tokamak plasma are presented. As this is a local measurement, this technique can in principle yield q profiles without the need of any de-convolution. The effect of the TFTR geometrical configuration and its various components on the expected measurement accuracy is discussed. The authors find that the measurement of q values within the inner half of the plasma should be possible, with only minor modification to the present TVTS system

  3. Improving the profile of the European tourist destinations through the European tourism indicators system

    Directory of Open Access Journals (Sweden)

    Laura CISMARU

    2015-06-01

    Full Text Available Within the most recent European Policy for Tourism, the competitiveness of the European tourism industry is directly linked to the image of Europe and to its perception, as a collection of sustainable and high-quality tourist destinations. In such context, improving the profile of the European tourist destinations has become a main target. During the last years, the European Commission focused on the sustainable development of tourist destinations. Several projects were developed, the most recent one introducing a practical tool - the European Tourism Indicators System (ETIS for the sustainable development of destinations. The present paper advances the idea that such tool can be successfully used in order to achieve the goal of improving the profile of the European tourist destinations.

  4. Exploring personalized searches using tag-based user profiles and resource profiles in folksonomy.

    Science.gov (United States)

    Cai, Yi; Li, Qing; Xie, Haoran; Min, Huaqin

    2014-10-01

    With the increase in resource-sharing websites such as YouTube and Flickr, many shared resources have arisen on the Web. Personalized searches have become more important and challenging since users demand higher retrieval quality. To achieve this goal, personalized searches need to take users' personalized profiles and information needs into consideration. Collaborative tagging (also known as folksonomy) systems allow users to annotate resources with their own tags, which provides a simple but powerful way for organizing, retrieving and sharing different types of social resources. In this article, we examine the limitations of previous tag-based personalized searches. To handle these limitations, we propose a new method to model user profiles and resource profiles in collaborative tagging systems. We use a normalized term frequency to indicate the preference degree of a user on a tag. A novel search method using such profiles of users and resources is proposed to facilitate the desired personalization in resource searches. In our framework, instead of the keyword matching or similarity measurement used in previous works, the relevance measurement between a resource and a user query (termed the query relevance) is treated as a fuzzy satisfaction problem of a user's query requirements. We implement a prototype system called the Folksonomy-based Multimedia Retrieval System (FMRS). Experiments using the FMRS data set and the MovieLens data set show that our proposed method outperforms baseline methods. Copyright © 2014 Elsevier Ltd. All rights reserved.

  5. Applied research of Primary Pump Mission Profile construction

    International Nuclear Information System (INIS)

    Zheng, Gang-yang; Zhang, Zhi-jian; Ye, Quan-liu; Du, Zhi-hao; Ma, Ying-fei; Zhang, Hua-zhi

    2017-01-01

    Highlights: • Minimum Associated Subtask (MAS) and Minimum Effective Component (MEC) are presented in Mission Profile analysis. • Via applying MAS and MEC, Mission Profile plays a more important role in complex system reliability analysis. • Mission Profile has already been used in the reliability analysis of localized Chinese 1000 MW NPP Primary Pump. - Abstract: The traditional Mission Profile analysis did not clarify the accurate concept of minimum subtask and component. However, there are several components, which could be the influencing key element of the system reliability; and there are several subtasks, which could be used as a basic and crucial mission. In this paper, traditional method of Mission Profile has been extended by incorporating two new ideas: Minimum Associated Subtask (MAS) and Minimum Effective Component (MEC). This method of Mission Profile modeling is derived from Chinese 1000 MW NPP Primary Pump localization. A case study on Primary Pump reliability has been presented; then, MAS and MEC have been existed as vital elements in its lifecycle profile construction. By means of MAS and MEC, Mission Profile plays a more important role on complex system (Primary Pump) reliability analysis.

  6. Whole Tumor Histogram-profiling of Diffusion-Weighted Magnetic Resonance Images Reflects Tumorbiological Features of Primary Central Nervous System Lymphoma.

    Science.gov (United States)

    Schob, Stefan; Münch, Benno; Dieckow, Julia; Quäschling, Ulf; Hoffmann, Karl-Titus; Richter, Cindy; Garnov, Nikita; Frydrychowicz, Clara; Krause, Matthias; Meyer, Hans-Jonas; Surov, Alexey

    2018-04-01

    Diffusion weighted imaging (DWI) quantifies motion of hydrogen nuclei in biological tissues and hereby has been used to assess the underlying tissue microarchitecture. Histogram-profiling of DWI provides more detailed information on diffusion characteristics of a lesion than the standardly calculated values of the apparent diffusion coefficient (ADC)-minimum, mean and maximum. Hence, the aim of our study was to investigate, which parameters of histogram-profiling of DWI in primary central nervous system lymphoma can be used to specifically predict features like cellular density, chromatin content and proliferative activity. Pre-treatment ADC maps of 21 PCNSL patients (8 female, 13 male, 28-89 years) from a 1.5T system were used for Matlab-based histogram profiling. Results of histopathology (H&E staining) and immunohistochemistry (Ki-67 expression) were quantified. Correlations between histogram-profiling parameters and neuropathologic examination were calculated using SPSS 23.0. The lower percentiles (p10 and p25) showed significant correlations with structural parameters of the neuropathologic examination (cellular density, chromatin content). The highest percentile, p90, correlated significantly with Ki-67 expression, resembling proliferative activity. Kurtosis of the ADC histogram correlated significantly with cellular density. Histogram-profiling of DWI in PCNSL provides a comprehensible set of parameters, which reflect distinct tumor-architectural and tumor-biological features, and hence, are promising biomarkers for treatment response and prognosis. Copyright © 2018. Published by Elsevier Inc.

  7. Beam profile monitor

    International Nuclear Information System (INIS)

    Krausse, G.J.; Gram, P.A.M.

    1978-05-01

    A system used to monitor secondary beam profiles at the LAMPF Linac for channel tune-up and diagnostics is described. The multiwire proportional chamber design is discussed, and descriptions and drawings of the gate card, the amplifier/multiplexer card, the output amplifier card, and the overall system are given

  8. Noise reduction technology reduces radiation dose in chronic total occlusions percutaneous coronary intervention: a propensity score-matched analysis.

    Science.gov (United States)

    Maccagni, Davide; Benincasa, Susanna; Bellini, Barbara; Candilio, Luciano; Poletti, Enrico; Carlino, Mauro; Colombo, Antonio; Azzalini, Lorenzo

    2018-03-23

    Chronic total occlusions (CTO) percutaneous coronary intervention (PCI) is associated with high radiation dose. Our study aim was to evaluate the impact of the implementation of a noise reduction technology (NRT) on patient radiation dose during CTO PCI. A total of 187 CTO PCIs performed between February 2016 and May 2017 were analyzed according to the angiographic systems utilized: Standard (n = 60) versus NRT (n = 127). Propensity score matching (PSM) was performed to control for differences in baseline characteristics. Primary endpoints were Cumulative Air Kerma at Interventional Reference Point (AK at IRP), which correlates with patient's tissue reactions; and Kerma Area Product (KAP), a surrogate measure of patient's risk of stochastic radiation effects. An Efficiency Index (defined as fluoroscopy time/AK at IRP) was calculated for each procedure. Image quality was evaluated using a 5-grade Likert-like scale. After PSM, n = 55 pairs were identified. Baseline and angiographic characteristics were well matched between groups. Compared to the Standard system, NRT was associated with lower AK at IRP [2.38 (1.80-3.66) vs. 3.24 (2.04-5.09) Gy, p = 0.035], a trend towards reduction for KAP [161 (93-244) vs. 203 (136-363) Gycm 2 , p = 0.069], and a better Efficiency Index [16.75 (12.73-26.27) vs. 13.58 (9.92-17.63) min/Gy, p = 0.003]. Image quality was similar between the two groups (4.39 ± 0.53 Standard vs. 4.34 ± 0.47 NRT, p = 0.571). In conclusion, compared with a Standard system, the use of NRT in CTO PCI is associated with lower patient radiation dose and similar image quality.

  9. Facetten der Kooperation von christlicher und muslimischer Theologie an der Universität Wien

    Directory of Open Access Journals (Sweden)

    Ednan Aslan

    2015-11-01

    Full Text Available ENGLISH: The Islamic Religious Pedagogy programme at the University of Vienna was the first one of its kind at a European university. With its establishment it became centre stage in politics and media. At the beginning the programme could not meet the high expectations it was subjected to due to a lack of professional staff. At this difficult phase the programme benefited greatly from the cooperation with the faculties of Catholic and Protestant Theology as the programme was able to learn from the established Christian religious educationalists. This learning process was particularly geared towards teaching, research and interreligious encounters. DEUTSCH: Die Islamische Religionspädagogik (IRP an der Universität Wien war das erste entsprechende Institut an einer europäischen Universität. Mit der Gründung trat die IRP in das Rampenlicht von Politik und Medien. In ihren Anfängen war die IRP den sehr hohen Erwartungen fachlich wie personell kaum gewachsen. In dieser schwierigen Phase spielte die Zusammenarbeit mit der Katholisch-Theologischen (KTF sowie der Evangelisch-Theologischen Fakultät (ETF eine wichtige Rolle, weil die IRP von den fachlichen Erfahrungen der etablierten christlichen Religionspädagogiken lernen konnte. Dieser Lernprozess bezog sich insbesondere auf Lehre, Forschung und interreligiöse Begegnung.

  10. Development of a measuring system for poloidal field profile in JIPP T-IIU plasmas

    International Nuclear Information System (INIS)

    Kuramoto, Hideharu; Hiraki, Naoji; Moriyama, Shin-ichi; Toi, Kazuo; Sato, Kuninori.

    1995-01-01

    A Zeeman polarimeter has been developed to measure the poloidal magnetic field profile in the plasma edge of the JIPP T-IIU tokamak. The poloidal field strength is determined from the analysis of circular polarization of a HeII 4686A spectral lines emitted from a plasma. The polarization modulation rate, which is proportional to the magnetic field strength along a line of sight, is estimated as a ratio of the difference between the left-hand circular polarized line intensity and right-hand one to the sum of them. A newly developed fast scanning Fabry-Perot interferometer allows us to improve a time resolution up to 1.5 ms. The poloidal magnetic field profile in He-doped deuterium plasmas of JIPP T-IIU has been successfully obtained with this polarimeter system. (author)

  11. Full area covered 3D profile measurement of special-shaped optics based on a new prototype non-contact profiler.

    Science.gov (United States)

    Du, Hui-Lin; Zhou, Zhao-Zhong; Sun, Ze-Qing; Ju, Bing-Feng; Xu, Shaoning; Sun, Anyu

    2017-06-01

    A new prototype non-contact profiler based on surface tracking has been specially developed. Surface tracking is carried out by a specially designed dual stage probe system with the aid of a four-Degree Of Freedom high-precision motion platform. The dual stage probe system keeps a short-range optical probe constantly tracking the surface by a self-developed voice coil motor servo, by which a wide measuring range of up to 10 mm is realized. The system performance evaluation including resolution, repeatability, and scanning speed proved the good capability of the new prototype non-contact profiler. To realize a full area covered 3D profile measurement of special-shaped optics within one scanning procedure, a signal intensity monitor integrated in the surface tracking controller is specially developed. In the experiment, a snip-single-corner-rectangular-shaped freeform surface was successfully measured over full area by the new non-contact profiler. This work provides an effective solution for 3D profile measurement of special-shaped optical surfaces over full reflecting area. Experimental results demonstrate that the proposed measuring system is of great significance in quality evaluation of optical surfaces.

  12. Community-aware user profile enrichment in folksonomy.

    Science.gov (United States)

    Xie, Haoran; Li, Qing; Mao, Xudong; Li, Xiaodong; Cai, Yi; Rao, Yanghui

    2014-10-01

    In the era of big data, collaborative tagging (a.k.a. folksonomy) systems have proliferated as a consequence of the growth of Web 2.0 communities. Constructing user profiles from folksonomy systems is useful for many applications such as personalized search and recommender systems. The identification of latent user communities is one way to better understand and meet user needs. The behavior of users is highly influenced by the behavior of their neighbors or community members, and this can be utilized in constructing user profiles. However, conventional user profiling techniques often encounter data sparsity problems as data from a single user is insufficient to build a powerful profile. Hence, in this paper we propose a method of enriching user profiles based on latent user communities in folksonomy data. Specifically, the proposed approach contains four sub-processes: (i) tag-based user profiles are extracted from a folksonomy tripartite graph; (ii) a multi-faceted folksonomy graph is constructed by integrating tag and image affinity subgraphs with the folksonomy tripartite graph; (iii) random walk distance is used to unify various relationships and measure user similarities; (iv) a novel prototype-based clustering method based on user similarities is used to identify user communities, which are further used to enrich the extracted user profiles. To evaluate the proposed method, we conducted experiments using a public dataset, the results of which show that our approach outperforms previous ones in user profile enrichment. Copyright © 2014 Elsevier Ltd. All rights reserved.

  13. Impact of Scheduling Flexibility on Demand Profile Flatness and User Inconvenience in Residential Smart Grid System

    Directory of Open Access Journals (Sweden)

    Naveed Ul Hassan

    2013-12-01

    Full Text Available The objective of this paper is to study the impact of scheduling flexibility on both demand profile flatness and user inconvenience in residential smart grid systems. Temporal variations in energy consumption by end users result in peaks and troughs in the aggregated demand profile. In a residential smart grid, some of these peaks and troughs can be eliminated through appropriate load balancing algorithms. However, load balancing requires user participation by allowing the grid to re-schedule some of their loads. In general, more scheduling flexibility can result in more demand profile flatness, however the resulting inconvenience to users would also increase. In this paper, our objective is to help the grid determine an appropriate amount of scheduling flexibility that it should demand from users, based on which, proper incentives can be designed. We consider three different types of scheduling flexibility (delay, advance scheduling and flexible re-scheduling in flexible loads and develop both optimal and sub-optimal scheduling algorithms. We discuss their implementation in centralized and distributed manners. We also identify the existence of a saturation point. Beyond this saturation point, any increase in scheduling flexibility does not significantly affect the flatness of the demand profile while user inconvenience continues to increase. Moreover, full participation of all the households is not required since increasing user participation only marginally increases demand profile flatness.

  14. The Effects of a Roommate-Pairing Program on International Student Satisfaction and Academic Success

    OpenAIRE

    Tolman, Steven

    2017-01-01

    While great attention has been given to the growth of international students at U.S. institutions, there is a gap in the literature examining support for this student population within residence halls. To address the gap, this quantitative study evaluated an international roommate-pairing program (IRP) by comparing the residential experience of IRP participants with a control group. The results showed the roommate-pairing program had a positive impact on the residential expe...

  15. Local flow management/profile descent algorithm. Fuel-efficient, time-controlled profiles for the NASA TSRV airplane

    Science.gov (United States)

    Groce, J. L.; Izumi, K. H.; Markham, C. H.; Schwab, R. W.; Thompson, J. L.

    1986-01-01

    The Local Flow Management/Profile Descent (LFM/PD) algorithm designed for the NASA Transport System Research Vehicle program is described. The algorithm provides fuel-efficient altitude and airspeed profiles consistent with ATC restrictions in a time-based metering environment over a fixed ground track. The model design constraints include accommodation of both published profile descent procedures and unpublished profile descents, incorporation of fuel efficiency as a flight profile criterion, operation within the performance capabilities of the Boeing 737-100 airplane with JT8D-7 engines, and conformity to standard air traffic navigation and control procedures. Holding and path stretching capabilities are included for long delay situations.

  16. A predictable Java profile

    DEFF Research Database (Denmark)

    Bøgholm, Thomas; Hansen, Rene Rydhof; Ravn, Anders Peter

    2009-01-01

    A Java profile suitable for development of high integrity embedded systems is presented. It is based on event handlers which are grouped in missions and equipped with respectively private handler memory and shared mission memory. This is a result of our previous work on developing a Java profile......, and is directly inspired by interactions with the Open Group on their on-going work on a safety critical Java profile (JSR-302). The main contribution is an arrangement of the class hierarchy such that the proposal is a generalization of Real-Time Specification for Java (RTSJ). A further contribution...

  17. Effect of readout direction in the edge profile on the modulation transfer function of computed radiographic systems by use of the edge method.

    Science.gov (United States)

    Tanaka, Nobukazu; Morishita, Junji; Tsuda, Norisato; Ohki, Masafumi

    2013-07-01

    We investigated the effect of the readout direction of the edge profile obtained by the edge method on the presampled modulation transfer function (MTF) in various computed radiographic (CR) systems. There were no differences in the MTFs derived from two edge profiles in the sub-scanning direction of four CR systems used in this study. On the other hand, the MTFs measured at a readout direction from the low (edge) to the high (direct exposure) exposure region were higher than those measured at a readout direction from the high to the low exposure region in the laser-beam scanning direction for three of the four CR systems. Although this phenomenon depends on the CR system, it is important to understand and indicate both MTFs at the two edge profiles in the laser-beam scanning direction for accurate assessment of the resolution property.

  18. Initial review and analysis of the direct environmental impacts of CSP in the northern Cape, South Africa

    Science.gov (United States)

    Rudman, Justine; Gauché, Paul; Esler, Karen J.

    2016-05-01

    The Integrated Resource Plan (IRP) of 2010 and the IRP Update provide the most recent guidance to the electricity generation future of South Africa (SA) and both plans include an increased proportion of renewable energy generation capacity. Given that SA has abundant renewable energy resource potential, this inclusion is welcome. Only 600 MW of the capacity allocated to concentrating solar power (CSP) has been committed to projects in the Northern Cape and represents roughly a fifth of the capacity that has been included in the IRP. Although CSP is particularly new in the electricity generation system of the country, the abundant solar resources of the region with annual DNI values of above 2900 kWh/m2 across the arid Savannah and Nama-Karoo biomes offer a promising future for the development of CSP in South Africa. These areas have largely been left untouched by technological development activities and thus renewable energy projects present a variety of possible direct and indirect environmental, social and economic impacts. Environmental Impact Assessments do focus on local impacts, but given that ecological processes often extend to regional- and landscape scales, understanding this scaled context is important to the alignment of development- and conservation priorities. Given the capacities allocated to CSP for the future of SA's electricity generation system, impacts on land, air, water and biodiversity which are associated with CSP are expected to increase in distribution and the understanding thereof deems valuable already from this early point in CSP's future in SA. We provide a review of direct impacts of CSP on the natural environment and an overview of the anticipated specific significance thereof in the Northern Cape.

  19. Health profile of freedom-deprived men in the prison system.

    Science.gov (United States)

    Pinheiro, Marília Cléssia; de Araújo, Janieiry Lima; de Vasconcelos, Renata Borges; do Nascimento, Ellany Gurgel Cosme

    2015-01-01

    To understand the needs and health profile of men incarcerated in the Pau dos Ferros Regional Criminal Complex (Rio Grande do Norte, Brazil). Quanti-qualitative research conducted with 30 men incarcerated in November 2012. Semi-structured interviews were the primary data collection method. Descriptive statistics and thematic analysis of the speeches were used for data analysis. The participants' health profile, resulting from deficits in living conditions prior to their imprisonment, is heightened by the degrading conditions of their prison stay, and plays a role in their exclusion and lack of care when admitted as prisoners. The disorders and symptoms most often self-reported by participants were: headache (86.6%), respiratory infections (66.6%), diarrhea (60.0%), stress (60.0%), and depression or deep sadness (56.6%). The responses showed that there is a social gap, especially related to health care, in the prison complex. We recognize a need to ensure the physical and moral integrity of inmates, which is compromised by life in prison; the inmates' health problems and needs differ from those of the general population, and require solutions; the inmates' health-disease process deteriorates due to the mere situation of entering the prison system; the inmates' health problems and health needs are treated with palliative and / or no assistance by those legally responsible for their protection; few human and financial resources exist to ensure health actions for the inmates; and there are no interventions or actions of disease prevention and health promotion.

  20. 1H NMR-based metabolic profiling reveals inherent biological variation in yeast and nematode model systems

    International Nuclear Information System (INIS)

    Szeto, Samuel S. W.; Reinke, Stacey N.; Lemire, Bernard D.

    2011-01-01

    The application of metabolomics to human and animal model systems is poised to provide great insight into our understanding of disease etiology and the metabolic changes that are associated with these conditions. However, metabolomic studies have also revealed that there is significant, inherent biological variation in human samples and even in samples from animal model systems where the animals are housed under carefully controlled conditions. This inherent biological variability is an important consideration for all metabolomics analyses. In this study, we examined the biological variation in 1 H NMR-based metabolic profiling of two model systems, the yeast Saccharomyces cerevisiae and the nematode Caenorhabditis elegans. Using relative standard deviations (RSD) as a measure of variability, our results reveal that both model systems have significant amounts of biological variation. The C. elegans metabolome possesses greater metabolic variance with average RSD values of 29 and 39%, depending on the food source that was used. The S. cerevisiae exometabolome RSD values ranged from 8% to 12% for the four strains examined. We also determined whether biological variation occurs between pairs of phenotypically identical yeast strains. Multivariate statistical analysis allowed us to discriminate between pair members based on their metabolic phenotypes. Our results highlight the variability of the metabolome that exists even for less complex model systems cultured under defined conditions. We also highlight the efficacy of metabolic profiling for defining these subtle metabolic alterations.

  1. Sensitivity profiles calculated with the UNISENS system

    International Nuclear Information System (INIS)

    Claro, L.H.; Menezes, A.

    1985-01-01

    Sensitivity profiles of the multiplication factor and several central reaction ratios for benchmarks ZPR 6/7, ZPR 3/11, FLATTOP-25, GODIVA and BIG-TEN, are presented in grafic form. A possible utilization is showed throught some modification to the ENDF/B-IV data file proposed for version ENDF/B-V. (Author) [pt

  2. Development of a Millimeter-Wave Beam Position and Profile Monitor for Transmission Efficiency Improvement in an ECRH System

    Directory of Open Access Journals (Sweden)

    Shimozuma T.

    2015-01-01

    Full Text Available In a high power Electron Cyclotron Resonance Heating (ECRH system, a long-distance and low-loss transmission system is required to realize effective heating of nuclear fusion-relevant plasmas. A millimeter-wave beam position and profile monitor, which can be used in a high-power, evacuated, and cooled transmission line, is proposed, designed, manufactured, and tested. The beam monitor consists of a reflector, Peltier-device array and a heat-sink. It was tested using simulated electric heater power or gyrotron output power. The data obtained from the monitor were well agreed with the heat source position and profile. The methods of data analysis and mode-content analysis of a propagating millimeter-wave in the corrugated wave-guide are proposed.

  3. A Meta-Analysis of the Incidence of Patient-Reported Dysphagia After Anterior Cervical Decompression and Fusion with the Zero-Profile Implant System.

    Science.gov (United States)

    Yang, Yi; Ma, Litai; Liu, Hao; Xu, MangMang

    2016-04-01

    Dysphagia is a well-known complication following anterior cervical surgery. It has been reported that the Zero-profile Implant System can decrease the incidence of dysphagia following surgery, however, dysphagia after anterior cervical decompression and fusion (ACDF) with the Zero-profile Implant System remains controversial. Previous studies only focus on small sample sizes. The objective of this study was to determine the incidence of dysphagia after ACDF with the Zero-profile Implant System. Studies were collected from PubMed, EMBASE, the Cochrane library and the China Knowledge Resource Integrated Database using the keywords "Zero-profile OR Zero-p) AND (dysphagia OR [swallowing dysfunction]". The software STATA (Version 13.0) was used for statistical analysis. Statistical heterogeneity across the various trials, a test of publication bias and sensitivity analysis was performed. 30 studies with a total of 1062 patients were included in this meta-analysis. The occurrence of post-operative transient dysphagia ranged from 0 to 76 % whilst the pooled incidence was 15.6 % (95 % CI, 12.6, 18.5 %). 23 studies reported no persistent dysphagia whilst seven studies reported persistent dysphagia ranging from 1 to 7 %). In summary, the present study observed a low incidence of both transient and persistent dysphagia after ACDF using the Zero-profile Implant System. Most of the dysphagia was mild and gradually decreased during the following months. Moderate or severe dysphagia was uncommon. Future randomized controlled multi-center studies and those focusing on the mechanisms of dysphagia and methods to reduce its incidence are required.

  4. Global oil company profiles

    International Nuclear Information System (INIS)

    1997-01-01

    Global Oil Company Profiles provides a comprehensive review of 50 of the top oil companies in the world. Each chapter is devoted to an individual company, providing an invaluable insight into the organisation, its structure and operations. Using the most recent data available, the report offers an up-to-date analysis of performance and future direction, as well as a unique benchmarking system for each company profiled. (author)

  5. BOREAS AFM-06 Mean Wind Profile Data

    Science.gov (United States)

    Wilczak, James; Hall, Forrest G. (Editor); Newcomer, Jeffrey A. (Editor); Smith, David E. (Technical Monitor)

    2000-01-01

    The Boreal Ecosystem-Atmosphere Study (BOREAS) Airborne Fluxes and Meteorology (AFM)-6 team from the National Oceanic and Atmospheric Administration/Environment Technology Laboratory (NOAA/ETL) operated a 915-MHz wind/Radio Acoustic Sounding System (RASS) profiler system in the Southern Study Area (SSA) near the Old Jack Pine (OJP) tower from 21 May 1994 to 20 Sep 1994. The data set provides wind profiles at 38 heights, containing the variables of wind speed; wind direction; and the u-, v-, and w-components of the total wind. The data are stored in tabular ASCII files. The mean wind profile data are available from the Earth Observing System Data and Information System (EOSDIS) Oak Ridge National Laboratory (ORNL) Distributed Active Archive Center (DAAC). The data files are available on a CD-ROM (see document number 20010000884).

  6. Oral supplementation with Lactobacillus delbrueckii subsp. bulgaricus 8481 enhances systemic immunity in elderly subjects.

    Science.gov (United States)

    Moro-García, Marco Antonio; Alonso-Arias, Rebeca; Baltadjieva, Maria; Fernández Benítez, Carlos; Fernández Barrial, Manuel Amadeo; Díaz Ruisánchez, Enrique; Alonso Santos, Ricardo; Alvarez Sánchez, Magdalena; Saavedra Miján, Juan; López-Larrea, Carlos

    2013-08-01

    Throughout life, there is an aging of the immune system that causes impairment of its defense capability. Prevention or delay of this deterioration is considered crucial to maintain general health and increase longevity. We evaluated whether dietary supplementation with Lactobacillus delbrueckii subsp. bulgaricus 8481 could enhance the immune response in the elderly. This multi-center, double-blind, and placebo controlled study enrolled 61 elderly volunteers who were randomly assigned to receive either placebo or probiotics. Each capsule of probiotics contained at least 3 × 10(7)  L. delbrueckii subsp. bulgaricus 8481. Individuals in the study were administered three capsules per day for 6 months. Blood samples were obtained at baseline (time 0), end of month 3, and month 6. We characterized cell subpopulations, measured cytokines by flow cytometry, quantified T cell receptor excision circle (TREC) by real-time PCR (RT-PCR), and determined human β-defensin-2 (hBD-2) concentrations and human cytomegalovirus (CMV) titers by enzyme-linked immunosorbent assay (ELISA). Elderly responded to the intake of probiotic with an increase in the percentage of NK cells, an improvement in the parameters defining the immune risk profile (IRP), and an increase in the T cell subsets that are less differentiated. The probiotic group also showed decreased concentrations of the pro-inflammatory cytokine IL-8 but increased antimicrobial peptide hBD-2. These effects disappeared within 6 months of stopping the probiotic intake. Immunomodulation induced by L. delbrueckii subsp. bulgaricus 8481 could favor the maintenance of an adequate immune response, mainly by slowing the aging of the T cell subpopulations and increasing the number of immature T cells which are potential responders to new antigens.

  7. Ice-Tethered Profiler observations: Vertical profiles of temperature, salinity, oxygen, and ocean velocity from an Ice-Tethered Profiler buoy system

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This collection contains repeated vertical profiles of ocean temperature and salinity versus pressure, as well as oxygen and velocity for some instruments. Data were...

  8. Environmental Assessment for Construction of an Armed Forces Reserve Center Complex and Implementation of BRAC 05 Realignment Actions in Niagara Falls, New York

    Science.gov (United States)

    2007-07-01

    improve the management of the coast and inland waterways. New York State’s Coastal Area has been divided into four geographic regions: Long Island, New...Justice in Minority and Low-Income Populations. The EO is designed to focus the attention of federal agencies on the human health and environmental...alteration on an area designated as an IRP site needs a waiter from Headquarters, Air Force Reserve Command. Table 4-12. Summary of IRP Sites at

  9. ERM 593 Applied Project_Guidance for Reviewing and Approving a Waste Stream Profile in the Waste Compliance and Tracking System_Final_05-05-15

    Energy Technology Data Exchange (ETDEWEB)

    Elicio, Andy U. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-05-05

    My ERM 593 applied project will provide guidance for the Los Alamos National Laboratory Waste Stream Profile reviewer (i.e. RCRA reviewer) in regards to Reviewing and Approving a Waste Stream Profile in the Waste Compliance and Tracking System. The Waste Compliance and Tracking system is called WCATS. WCATS is a web-based application that “supports the generation, characterization, processing and shipment of LANL radioactive, hazardous, and industrial waste.” The LANL generator must characterize their waste via electronically by filling out a waste stream profile (WSP) in WCATS. Once this process is completed, the designated waste management coordinator (WMC) will perform a review of the waste stream profile to ensure the generator has completed their waste stream characterization in accordance with applicable state, federal and LANL directives particularly P930-1, “LANL Waste Acceptance Criteria,” and the “Waste Compliance and Tracking System User's Manual, MAN-5004, R2,” as applicable. My guidance/applied project will describe the purpose, scope, acronyms, definitions, responsibilities, assumptions and guidance for the WSP reviewer as it pertains to each panel and subpanel of a waste stream profile.

  10. Customer-focused planning: Beyond integrated resource planning

    International Nuclear Information System (INIS)

    Hastings, P.C.

    1992-01-01

    Integrated resource planning (IRP) evolved from the growing recognition by utilities and regulators that efforts to influence the use of electricity by customers could be more cost-effective than simply expanding the generation system. Improvements in IRP methodology are taking many different forms. One major effort is to move planning closer to the customer. Customer-focused planning (CFP) starts with customer values and uses these to drive decision-making within the utility. CFP is process- rather than product- oriented and typically operates at the bulk power system level. Options available to meet customer needs include electricity, alternative fuels, capital substitution, and end-use management or control. The customer selects the option(s) based on a value set that typically includes safety, reliability, convenience, and cost. There are also four possible levels of decision-making: the end-use; customer/power meter; transmission/distribution interface; and the utility bulk power system. Challenges of implementing CFP include identifying customer wants, needs, and values; integration of utility planning efforts; and the dynamics of the CFP process, in which costs can change with each modification of the transmission and distribution system. Two examples of recent moves toward CFP at Central Maine Power are reviewed. 2 refs., 1 fig

  11. World Energy Data System (WENDS). Volume X. Nuclear facility profiles, PO--ZA

    International Nuclear Information System (INIS)

    1979-06-01

    In this compendium each profile of a nuclear facility is a capsule summary of pertinent facts regarding that particular installation. The facilities described include the entire fuel cycle in the broadest sense, encompassing resource recovery through waste management. Power plants and all US facilities have been excluded. To facilitate comparison the profiles have been recorded in a standard format. Because of the breadth of the undertaking some data fields do not apply to the establishment under discussion and accordingly are blank. The set of nuclear facility profiles occupies four volumes; the profiles are ordered by country name, and then by facility code. Each nuclear facility profile volume contains two complete indexes to the information. The first index aggregates the facilities alphabetically by country. It is further organized by category of facility, and then by the four-character facility code. It provides a quick summary of the nuclear energy capability or interest in each country and also an identifier, the facility code, which can be used to access the information contained in the profile

  12. World Energy Data System (WENDS). Volume VIII. Nuclear facility profiles, CO--HU

    International Nuclear Information System (INIS)

    1979-06-01

    In this compendium each profile of a nuclear facility is a capsule summary of pertinent facts regarding that particular installation. The facilities described include the entire fuel cycle in the broadest sense, encompassing resource recovery through waste management. Power plants and all US facilities have been excluded. To facilitate comparison the profiles have been recorded in a standard format. Because of the breadth of the undertaking some data fields do not apply to the establishment under discussion and accordingly are blank. The set of nuclear facility profiles occupies four volumes; the profiles are ordered by country name, and then by facility code. Each nuclear facility profile volume contains two complete indexes to the information. The first index aggregates the facilities alphabetically by country. It is further organized by category of facility, and then by the four-character facility code. It provides a quick summary of the nuclear energy capability or interest in each country and also an identifier, the facility code, which can be used to access the information contained in the profile

  13. World Energy Data System (WENDS). Volume IX. Nuclear facility profiles, IN--PL

    International Nuclear Information System (INIS)

    1979-06-01

    In this compendium each profile of a nuclear facility is a capsule summary of pertinent facts regarding that particular installation. The facilities described include the entire fuel cycle in the broadest sense, encompassing resource recovery through waste management. Power plants and all US facilities have been excluded. To facilitate comparison the profiles have been recorded in a standard format. Because of the breadth of the undertaking some data fields do not apply to the establishment under discussion and accordingly are blank. The set of nuclear facility profiles occupies four volumes; the profiles are ordered by country name, and then by facility code. Each nuclear facility profile volume contains two complete indexes to the information. The first index aggregates the facilities alphabetically by country. It is further organized by category of facility, and then by the four-character facility code. It provides a quick summary of the nuclear energy capability or interest in each country and also an identifier, the facility code, which can be used to access the information contained in the profile

  14. World Energy Data System (WENDS). Volume VII. Nuclear facility profiles, AG--CH

    International Nuclear Information System (INIS)

    1979-06-01

    In this compendium each profile of a nuclear facility is a capsule summary of pertinent facts regarding that particular installation. The facilities described include the entire fuel cycle in the broadest sense, encompassing resource recovery through waste management. Power plants and all US facilities have been excluded. To facilitate comparison the profiles have been recorded in a standard format. Because of the breadth of the undertaking some data fields do not apply to the establishment under discussion and accordingly are blank. The set of nuclear facility profiles occupies four volumes; the profiles are ordered by country name, and then by facility code. Each nuclear facility profile volume contains two complete indexes to the information. The first index aggregates the facilities alphabetically by country. It is further organized by category of facility, and then by the four-character facility code. It provides a quick summary of the nuclear energy capability or interest in each country and also an identifier, the facility code, which can be used to access the information contained in the profile

  15. A quasi-sequential parameter estimation for nonlinear dynamic systems based on multiple data profiles

    Energy Technology Data Exchange (ETDEWEB)

    Zhao, Chao [FuZhou University, FuZhou (China); Vu, Quoc Dong; Li, Pu [Ilmenau University of Technology, Ilmenau (Germany)

    2013-02-15

    A three-stage computation framework for solving parameter estimation problems for dynamic systems with multiple data profiles is developed. The dynamic parameter estimation problem is transformed into a nonlinear programming (NLP) problem by using collocation on finite elements. The model parameters to be estimated are treated in the upper stage by solving an NLP problem. The middle stage consists of multiple NLP problems nested in the upper stage, representing the data reconciliation step for each data profile. We use the quasi-sequential dynamic optimization approach to solve these problems. In the lower stage, the state variables and their gradients are evaluated through ntegrating the model equations. Since the second-order derivatives are not required in the computation framework this proposed method will be efficient for solving nonlinear dynamic parameter estimation problems. The computational results obtained on a parameter estimation problem for two CSTR models demonstrate the effectiveness of the proposed approach.

  16. A quasi-sequential parameter estimation for nonlinear dynamic systems based on multiple data profiles

    International Nuclear Information System (INIS)

    Zhao, Chao; Vu, Quoc Dong; Li, Pu

    2013-01-01

    A three-stage computation framework for solving parameter estimation problems for dynamic systems with multiple data profiles is developed. The dynamic parameter estimation problem is transformed into a nonlinear programming (NLP) problem by using collocation on finite elements. The model parameters to be estimated are treated in the upper stage by solving an NLP problem. The middle stage consists of multiple NLP problems nested in the upper stage, representing the data reconciliation step for each data profile. We use the quasi-sequential dynamic optimization approach to solve these problems. In the lower stage, the state variables and their gradients are evaluated through ntegrating the model equations. Since the second-order derivatives are not required in the computation framework this proposed method will be efficient for solving nonlinear dynamic parameter estimation problems. The computational results obtained on a parameter estimation problem for two CSTR models demonstrate the effectiveness of the proposed approach

  17. Design of the beam profile monitor system for the RHIC injection line

    International Nuclear Information System (INIS)

    Witkover, R.L.

    1995-01-01

    A video profile monitor (VPM) system will be used in the AGS-to-RHIC (ATR) transfer line to acquire single bunches transferred at 30 Hz. An array of 12 video cameras will be connected to 4 frame grabbers through a wide-band flux. Fast VME image processing boards will analyze a 120 x 120 subset of the image, generated by a 4 x 4 convolution or an ROI computation and sent over the network during the AGS recycle time. Details of the design, results of lab tests and studies with ion and proton beams will be presented

  18. Integrated resource planning for local gas distribution companies: A critical review of regulatory policy issues

    International Nuclear Information System (INIS)

    Harunuzzaman, M.; Islam, M.

    1994-08-01

    According to the report, public utility commissions (PUCs) are increasingly adopting, or considering the adoption of integrated resource planning (IRP) for local gas distribution companies (LDCs). The Energy Policy Act of 1992 (EPAct) requires PUCs to consider IRP for gas LDCs. This study has two major objectives: (1) to help PUCs develop appropriate regulatory approaches with regard to IRP for gas LDCs; and (2) to help PUCs respond to the EPAct directive. The study finds that it is appropriate for PUCs to pursue energy efficiency within the traditional regulatory framework of minimizing private costs of energy production and delivery; and PUCs should play a limited role in addressing environmental externalities. The study also finds that in promoting energy efficiency, PUCs should pursue policies that are incentive-based, procompetitive, and sensitive to rate impacts. The study evaluates a number of traditional and nontraditional ratemaking mechanisms on the basis of cost minimization, energy efficiency, competitiveness, and other criteria. The mechanisms evaluated include direct recovery of DSM expenses, lost revenue adjustments for DSM options, revenue decoupling mechanisms, sharing of DSM cost savings, performance-based rate of return for DSM, provision of DSM as a separate service, deregulation of DSM service, price caps, and deregulation of the noncore gas market. The study concludes with general recommendations for regulatory approaches and ratemaking mechanisms that PUCs may wish to consider in advancing IRP objectives

  19. Examining the potential of natural gas demand-side measures to benefit customers, the distribution utility, and the environment: two case studies from Europe

    International Nuclear Information System (INIS)

    Almeida, A.T. de; Carvalho, A.; Mariano, J.; Broege, M.

    2004-01-01

    The aim of this paper is to demonstrate how integrated resource planning (IRP) oriented to the gas sector can be applied both in new networks and in mature networks, and to present the advantages of its application. One case study is described, in the western central region of Portugal, to illustrate the results of a pilot project on natural gas IRP implementation in a new network in the European Union (EU). The city of Burg, Germany, with a mature gas network with district heating was also analysed in terms of IRP potential. The most important phases of the integrated resource plan definition and implementation (especially those oriented to the demand-side) are presented, namely, the definition of the most efficient technologies (including solar energy), fuel-switching possibilities, a detailed study of the impacts in the economy, environment and society, and the policy incentives necessary to motivate the gas utility companies to perform IRP. In the main case study, the suggested implementation plan would lead to a reduction of around 4.7% in natural gas consumption. Additionally, 13.3% of cost-effective fuel switching from other competing forms of energy to natural gas can be achieved. A proposed EU energy services directive on mandatory energy-efficiency activities for gas and electricity distribution utilities in the EU, will promote the large-scale implementation of the proposed approach in Europe. (author)

  20. Health profile of freedom-deprived men in the prison system

    Directory of Open Access Journals (Sweden)

    Marília Cléssia Pinheiro

    2015-08-01

    Full Text Available Objective. To understand the needs and health profile of men incarcerated in the Pau dos Ferros Regional Criminal Complex (Rio Grande do Norte, Brazil. Methodology. Quanti-qualitative research conducted with 30 men incarcerated in November 2012. Semi-structured interviews were the primary data collection method. Descriptive statistics and thematic analysis of the speeches were used for data analysis. Results. The participants' health profile, resulting from deficits in living conditions prior to their imprisonment, is heightened by the degrading conditions of their prison stay, and plays a role in their exclusion and lack of care when admitted as prisoners. The disorders and symptoms most often self-reported by participants were: headache (86.6%, respiratory infections (66.6%, diarrhea (60.0%, stress (60.0%, and depression or deep sadness (56.6%. The responses showed that there is a social gap, especially related to health care, in the prison complex. Conclusion. We recognize a need to ensure the physical and moral integrity of inmates, which is compromised by life in prison; the inmates' health problems and needs differ from those of the general population, and require solutions; the inmates' health-disease process deteriorates due to the mere situation of entering the prison system; the inmates' health problems and health needs are treated with palliative and / or no assistance by those legally responsible for their protection; few human and financial resources exist to ensure health actions for the inmates; and there are no interventions or actions of disease prevention and health promotion.

  1. Update on the REIPPPP, clean coal, nuclear, natural gas

    CSIR Research Space (South Africa)

    Milazi, Dominic

    2015-12-01

    Full Text Available , clean coal, nuclear, natural gas The Sustainable Energy Resource Handbook Volume 6 Dominic Milazi, Dr Tobias Bischof-Niemz, Abstract Since its release in 2011, the Integrated Resource Plan (IRP 2010-2030), or IRP 2010, has been the authoritative... text setting out South Africa’s electricity plan over the next 20 years. The document indicates timelines on the roll out of key supply side options such as renewable energy, the nuclear, natural gas and coal build programmes, as well as peaking...

  2. Elements for an integrated resource planning in the framework of river basins: a study for the Cuiaba River Basin; Elementos para um planejamento integrado de recursos no ambito de bacias hidrograficas: um estudo para a bacia do rio Cuiaba

    Energy Technology Data Exchange (ETDEWEB)

    Dorileo, Ivo Leandro; Bajay, Sergio Valdir [Universidade Estadual de Campinas (NIPE/UNICAMP), SP (Brazil). Nucleo Interdisciplinar de Planejamento Energetico. Dept. de Energia], e-mail: ildorileo@sigmanet.com.br, e-mail: bajay@fem.unicamp.br

    2008-07-01

    A new approach in energy planning in Brazil, IRP - Integrated Resources Planning for River Basins, gathers three main determinants of development: water, electricity and piped gas. This paper argues, briefly, the need of this planning, of indicative character, integrated with the River Basin Plans, and it presents a retrospective analysis concerning water, electricity and LPG demands of the economy sectors from Cuiaba River Basin region, priority elements to aid the prospective studies and to carry out process related to the IRP. (author)

  3. Understanding system dynamics of an adaptive enzyme network from globally profiled kinetic parameters.

    Science.gov (United States)

    Chiang, Austin W T; Liu, Wei-Chung; Charusanti, Pep; Hwang, Ming-Jing

    2014-01-15

    A major challenge in mathematical modeling of biological systems is to determine how model parameters contribute to systems dynamics. As biological processes are often complex in nature, it is desirable to address this issue using a systematic approach. Here, we propose a simple methodology that first performs an enrichment test to find patterns in the values of globally profiled kinetic parameters with which a model can produce the required system dynamics; this is then followed by a statistical test to elucidate the association between individual parameters and different parts of the system's dynamics. We demonstrate our methodology on a prototype biological system of perfect adaptation dynamics, namely the chemotaxis model for Escherichia coli. Our results agreed well with those derived from experimental data and theoretical studies in the literature. Using this model system, we showed that there are motifs in kinetic parameters and that these motifs are governed by constraints of the specified system dynamics. A systematic approach based on enrichment statistical tests has been developed to elucidate the relationships between model parameters and the roles they play in affecting system dynamics of a prototype biological network. The proposed approach is generally applicable and therefore can find wide use in systems biology modeling research.

  4. Convolution based profile fitting

    International Nuclear Information System (INIS)

    Kern, A.; Coelho, A.A.; Cheary, R.W.

    2002-01-01

    Full text: In convolution based profile fitting, profiles are generated by convoluting functions together to form the observed profile shape. For a convolution of 'n' functions this process can be written as, Y(2θ)=F 1 (2θ)x F 2 (2θ)x... x F i (2θ)x....xF n (2θ). In powder diffractometry the functions F i (2θ) can be interpreted as the aberration functions of the diffractometer, but in general any combination of appropriate functions for F i (2θ) may be used in this context. Most direct convolution fitting methods are restricted to combinations of F i (2θ) that can be convoluted analytically (e.g. GSAS) such as Lorentzians, Gaussians, the hat (impulse) function and the exponential function. However, software such as TOPAS is now available that can accurately convolute and refine a wide variety of profile shapes numerically, including user defined profiles, without the need to convolute analytically. Some of the most important advantages of modern convolution based profile fitting are: 1) virtually any peak shape and angle dependence can normally be described using minimal profile parameters in laboratory and synchrotron X-ray data as well as in CW and TOF neutron data. This is possible because numerical convolution and numerical differentiation is used within the refinement procedure so that a wide range of functions can easily be incorporated into the convolution equation; 2) it can use physically based diffractometer models by convoluting the instrument aberration functions. This can be done for most laboratory based X-ray powder diffractometer configurations including conventional divergent beam instruments, parallel beam instruments, and diffractometers used for asymmetric diffraction. It can also accommodate various optical elements (e.g. multilayers and monochromators) and detector systems (e.g. point and position sensitive detectors) and has already been applied to neutron powder diffraction systems (e.g. ANSTO) as well as synchrotron based

  5. Thermal Band Atmospheric Correction Using Atmospheric Profiles Derived from Global Positioning System Radio Occultation and the Atmospheric Infrared Sounder

    Science.gov (United States)

    Pagnutti, Mary; Holekamp, Kara; Stewart, Randy; Vaughan, Ronald D.

    2006-01-01

    This Rapid Prototyping Capability study explores the potential to use atmospheric profiles derived from GPS (Global Positioning System) radio occultation measurements and by AIRS (Atmospheric Infrared Sounder) onboard the Aqua satellite to improve surface temperature retrieval from remotely sensed thermal imagery. This study demonstrates an example of a cross-cutting decision support technology whereby NASA data or models are shown to improve a wide number of observation systems or models. The ability to use one data source to improve others will be critical to the GEOSS (Global Earth Observation System of Systems) where a large number of potentially useful systems will require auxiliary datasets as input for decision support. Atmospheric correction of thermal imagery decouples TOA radiance and separates surface emission from atmospheric emission and absorption. Surface temperature can then be estimated from the surface emission with knowledge of its emissivity. Traditionally, radiosonde sounders or atmospheric models based on radiosonde sounders, such as the NOAA (National Oceanic & Atmospheric Administration) ARL (Air Resources Laboratory) READY (Real-time Environmental Application and Display sYstem), provide the atmospheric profiles required to perform atmospheric correction. Unfortunately, these types of data are too spatially sparse and too infrequently taken. The advent of high accuracy, global coverage, atmospheric data using GPS radio occultation and AIRS may provide a new avenue for filling data input gaps. In this study, AIRS and GPS radio occultation derived atmospheric profiles from the German Aerospace Center CHAMP (CHAllenging Minisatellite Payload), the Argentinean Commission on Space Activities SAC-C (Satellite de Aplicaciones Cientificas-C), and the pair of NASA GRACE (Gravity Recovery and Climate Experiment) satellites are used as input data in atmospheric radiative transport modeling based on the MODTRAN (MODerate resolution atmospheric

  6. An Estimation Method of System Voltage Sag Profile using Recorded Sag Data

    Science.gov (United States)

    Tanaka, Kazuyuki; Sakashita, Tadashi

    The influence of voltage sag to electric equipment has become big issues because of wider utilization of voltage sensitive devices. In order to reduce the influence of voltage sag appearing at each customer side, it is necessary to recognize the level of receiving voltage drop due to lightning faults for transmission line. However it is hard to measure directly those sag level at every load node. In this report, a new method of efficiently estimating system voltage sag profile is proposed based on symmetrical coordinate. In the proposed method, limited recorded sag data is used as the estimation condition which is recorded at each substation in power systems. From the point of view that the number of the recorded node is generally far less than those of the transmission route, a fast solution method is developed to calculate only recorder faulted voltage by applying reciprocity theorem for Y matrix. Furthermore, effective screening process is incorporated, in which the limited candidate of faulted transmission line can be chosen. Demonstrative results are presented using the IEEJ East10 standard system and actual 1700 bus system. The results show that estimation accuracy is sufficiently acceptable under less computation labor.

  7. A new hybrid GA-PSO method for solving multi-period inventory routing problem with considering financial decisions

    Directory of Open Access Journals (Sweden)

    Masoud Rabbani

    2013-09-01

    Full Text Available Integration of various logistical components in supply chain management, such as transportation, inventory control and facility location are becoming common practice to avoid sub-optimization in nowadays’ competitive environment. The integration of transportation and inventory decisions is known as inventory routing problem (IRP in the literature. The problem aims to determine the delivery quantity for each customer and the network routes to be used in each period, so that the total inventory and transportation costs are to be minimized. On the contrary of conventional IRP that each retailer can only provide its demand from the supplier, in this paper, a new multi-period, multi-item IRP model with considering lateral trans-shipment, back-log and financial decisions is proposed as a business model in a distinct organization. The main purpose of this paper is applying an applicable inventory routing model with considering real world setting and solving it with an appropriate method.

  8. CAMEX-4 MIPS 915 MHZ DOPPLER WIND PROFILER V1

    Data.gov (United States)

    National Aeronautics and Space Administration — The University of Alabama in Huntsville (UAH) Mobile Integrated Profiling System (MIPS) is a mobile atmospheric profiling system. It includes a 915 MHz Doppler...

  9. Simulation-Based Optimization of a Vector Showerhead System for the Control of Flow Field Profile in a Vertical Reactor Chamber

    Directory of Open Access Journals (Sweden)

    Huanxiong Xia

    2014-03-01

    Full Text Available Optimization of a vector showerhead in a vertical reactor involves thousands of holes on the showerhead face plate and the spatial distribution of physical fields, so parameterizing the geometry configuration of the holes in high resolution is very difficult, which makes the conventional optimization methods hard to deal with. To solve this problem, a profile error feedback (PEF optimization solution was proposed to optimize a vector showerhead gas delivery system for the control of mass transport. The gas velocity profile in the reactor and the continuous-feature impedance distribution profile on the showerhead face plate are defined as design objective and variables, respectively. A cyclic iterative approximation idea was implemented in this solution. The algorithm was started from a guessed initial design model and then cyclically adjusted the design variables by the constructed PEF iterative formula to generate a better model and to make the gas velocity profile in the critical domain of the new model continually approximate to the expected profile, until it could be accepted. Finally, the optimized impedance profile was mapped to the holes geometry configuration through the established equivalent impedance model for the showerhead face plate.

  10. Adaptation of antenna profiles for control of MR guided hyperthermia (HT) in a hybrid MR-HT system

    International Nuclear Information System (INIS)

    Weihrauch, Mirko; Wust, Peter; Weiser, Martin; Nadobny, Jacek; Eisenhardt, Steffen; Budach, Volker; Gellermann, Johanna

    2007-01-01

    A combined numerical-experimental iterative procedure, based on the Gauss-Newton algorithm, has been developed for control of magnetic resonance (MR)-guided hyperthermia (HT) applications in a hybrid MR-HT system BSD 2000 3D-MRI. In this MR-HT system, composed of a 3-D HT applicator Sigma-Eye placed inside a tunnel-type MR tomograph Siemens MAGNETOM Symphony (1.5 T), the temperature rise due to the HT radiation can be measured on-line in three dimensions by use of the proton resonance frequency shift (PRFS) method. The basic idea of our iterative procedure is the improvement of the system's characterization by a step-by-step modification of the theoretical HT antenna profiles (electric fields radiated by single antennas). The adaptation of antenna profiles is efficient if the initial estimates are radiation fields calculated from a good a priori electromagnetic model. Throughout the iterative procedure, the calculated antenna fields (FDTD) are step-by-step modified by comparing the calculated and experimental data, the latter obtained using the PRFS method. The procedure has been experimentally tested on homogeneous and inhomogeneous phantoms. It is shown that only few comparison steps are necessary for obtaining a dramatic improvement of the general predictability and quality of the specific absorption rate (SAR) inside the MR-HT hybrid system

  11. User Profile Analysis Using an Online Social Network Integrated Quiz Game

    Directory of Open Access Journals (Sweden)

    Yusuf YASLAN

    2017-09-01

    Full Text Available User interest profiling is important for personalized web search, recommendation and retrieval systems. In order to develop a good personalized application one needs to have accurate representation of user profiles. Most of the personalized systems generate interest profiles from user declarations or inferred from cookies or visited web pages. But to achieve a certain result that satisfies the user needs, explicit definition of the user interests is needed. In this paper we propose to obtain interest profiles from a quiz game played by the user where at each play he/she is asked 10 questions from different categories with different difficulty levels. The developed quiz game is integrated to Facebook online social network. By doing so, we had the chance to extract each user’s both explicit Facebook interest profiles and implicit interest profiles from quiz game answers. These profiles are used to extract different features for each user. Both implicit interest profile and explicit interest profile features are evaluated for clustering and interest ranking tasks separately. The experimental results show that the implicit interest profile features have promising results on personalized systems.

  12. Integrated genomic classification of melanocytic tumors of the central nervous system using mutation analysis, copy number alterations and DNA methylation profiling.

    Science.gov (United States)

    Griewank, Klaus; Koelsche, Christian; van de Nes, Johannes A P; Schrimpf, Daniel; Gessi, Marco; Möller, Inga; Sucker, Antje; Scolyer, Richard A; Buckland, Michael E; Murali, Rajmohan; Pietsch, Torsten; von Deimling, Andreas; Schadendorf, Dirk

    2018-06-11

    In the central nervous system, distinguishing primary leptomeningeal melanocytic tumors from melanoma metastases and predicting their biological behavior solely using histopathologic criteria can be challenging. We aimed to assess the diagnostic and prognostic value of integrated molecular analysis. Targeted next-generation-sequencing, array-based genome-wide methylation analysis and BAP1 immunohistochemistry was performed on the largest cohort of central nervous system melanocytic tumors analyzed to date, incl. 47 primary tumors of the central nervous system, 16 uveal melanomas. 13 cutaneous melanoma metastasis and 2 blue nevus-like melanomas. Gene mutation, DNA-methylation and copy-number profiles were correlated with clinicopathological features. Combining mutation, copy-number and DNA-methylation profiles clearly distinguished cutaneous melanoma metastases from other melanocytic tumors. Primary leptomeningeal melanocytic tumors, uveal melanomas and blue nevus-like melanoma showed common DNA-methylation, copy-number alteration and gene mutation signatures. Notably, tumors demonstrating chromosome 3 monosomy and BAP1 alterations formed a homogeneous subset within this group. Integrated molecular profiling aids in distinguishing primary from metastatic melanocytic tumors of the central nervous system. Primary leptomeningeal melanocytic tumors, uveal melanoma and blue nevus-like melanoma share molecular similarity with chromosome 3 and BAP1 alterations markers of poor prognosis. Copyright ©2018, American Association for Cancer Research.

  13. Integrating user profile in medical CBIR systems to answer perceptual similarity queries

    Science.gov (United States)

    Bugatti, Pedro H.; Kaster, Daniel S.; Ponciano-Silva, Marcelo; Traina, Agma J. M.; Traina, Caetano, Jr.

    2011-03-01

    Techniques for Content-Based Image Retrieval (CBIR) have been intensively explored due to the increase in the amount of captured images and the need of fast retrieval of them. The medical field is a specific example that generates a large flow of information, especially digital images employed for diagnosing. One issue that still remains unsolved deals with how to reach the perceptual similarity. That is, to achieve an effective retrieval, one must characterize and quantify the perceptual similarity regarding the specialist in the field. Therefore, the present paper was conceived to fill in this gap creating a consistent support to perform similarity queries over medical images, maintaining the semantics of a given query desired by the user. CBIR systems relying in relevance feedback techniques usually request the users to label relevant images. In this paper, we present a simple but highly effective strategy to survey user profiles, taking advantage of such labeling to implicitly gather the user perceptual similarity. The user profiles maintain the settings desired for each user, allowing tuning the similarity assessment, which encompasses dynamically changing the distance function employed through an interactive process. Experiments using computed tomography lung images show that the proposed approach is effective in capturing the users' perception.

  14. Te and ne profiles on JFT-2M plasma with the highest spatial resolution TV Thomson scattering system

    International Nuclear Information System (INIS)

    Yamauchi, T.

    1993-01-01

    A high spatial resolution TV Thomson scattering system was constructed on JFT-2M tokamak. This system is similar to those used at PBX-M and TFTR. These systems are providing complete profiles of Te and ne at a single time during a plasma discharge. The characteristics of JFT-2M TVTS are as follows: 1. Measured points are composed of not only 81 points for the scattered light and plasma light, whose time difference is 2 ms, but also 10 points for plasma light measured at the same time with scattered light. 2. Spatial resolution is 0.86 cm, which is higher than any other Thomson scattering system. 3. Sensitivity of detector composed of image intensifier tubes and CCD is as high as that of photomultiplier tube. Te and ne profiles have been measured over one year on JFT-2M. The line-averaged electron density measured was in the region of 5x10 12 cm -3 - 7x10 13 cm -3 and the measured electron temperature was in the region of 50 eV -1.2 keV. (author) 7 refs., 7 figs., 1 tab

  15. THE BEHAVIORAL PROFILE OF HARVESTER OPERATORS

    Directory of Open Access Journals (Sweden)

    Millana Burger Pagnussat

    Full Text Available ABSTRACT This study aims to characterize the behavioral profile of harvester operators, with the goal of assisting forest managers in selecting and training new teams of employees. A forest company located in central-western Brazil was examined from a sample of 20 harvester operators that did not have experience carrying out the functions of their industry. A behavioral profile evaluation tool was used, consisting of a management system that creates a profile based on behavioral competencies; it was initially used to develop a profile of a high-performing harvester operator; or rather, a reference profile. Next, the behavioral profile of the operators were grouped into distinct classes and compared with the reference profile to identify traits that could positively or negatively affect an operators' performance. An optimal profile had the following qualities: attentive to details, meets deadlines and follows rules, technically-oriented, patient with repetitive tasks, the ability to avoid conflicts, and being an introvert. An improper profile included aspects such as aggressiveness, being argumentative, being persuasive, explosive, and tense at work. The behavioral profile evaluation tool can support the process of choosing forest machine operators; however, it is important to also consider skills and work experience.

  16. Design for measurement system of Doppler broadening profiles with the coincidence technique using a NaI detector in colinear geometry with the Ge detector

    International Nuclear Information System (INIS)

    Mori, Kazuteru; Uedono, Akira; Tanigawa, Shoichiro; Nakai, Katsuhiko

    1998-01-01

    The measurement system for Doppler broadening profiles with the coincidence technique using a NaI detector in colinear geometry with a Ge detector was developed. The principle of measurement system with the coincidence technique between the NaI detector and the Ge detector was described. Application of the system for the detection of vacancy-type defects introduced by electron irradiation in Czochralski-(Cz) grown Si was shown. Detail in the difference between the Doppler broadening profiles for Cz-Si and Si grown by the floating-zone method was also obtained. (author)

  17. Design for measurement system of Doppler broadening profiles with the coincidence technique using a NaI detector in colinear geometry with the Ge detector

    Energy Technology Data Exchange (ETDEWEB)

    Mori, Kazuteru; Uedono, Akira; Tanigawa, Shoichiro [Tsukuba Univ., Ibaraki (Japan). Inst. of Materials Science; Nakai, Katsuhiko

    1998-08-01

    The measurement system for Doppler broadening profiles with the coincidence technique using a NaI detector in colinear geometry with a Ge detector was developed. The principle of measurement system with the coincidence technique between the NaI detector and the Ge detector was described. Application of the system for the detection of vacancy-type defects introduced by electron irradiation in Czochralski-(Cz) grown Si was shown. Detail in the difference between the Doppler broadening profiles for Cz-Si and Si grown by the floating-zone method was also obtained. (author)

  18. Kinetic Profiles in NSTX Plasmas

    International Nuclear Information System (INIS)

    Bell, R.E.; LeBlanc, B.P.; Bourdelle, C.; Ernst, D.R.; Fredrickson, E.D.; Gates, D.A.; Hosea, J.C.; Johnson, D.W.; Kaye, S.M.; Maingi, R.; Medley, S.; Menard, J.E.; Mueller, D.; Ono, M.; Paoletti, F.; Peng, M.; Sabbagh, S.A.; Stutman, D.; Swain, D.W.; Synakowski, E.J.; Wilson, J.R.

    2001-01-01

    The National Spherical Torus Experiment (NSTX) is a low aspect ratio (R/a approximately 1.3) device with auxiliary heating from neutral-beam injection (NBI) and high-harmonic fast-wave heating (HHFW). Typical NSTX parameters are R(subscript ''0'') = 85 cm, a = 67 cm, I(subscript ''p'') = 0.7-1.4 MA, B(subscript ''phi'') = 0.25-0.45 T. Three co-directed deuterium neutral-beam sources have injected P(subscript ''NB'') less than or equal to 4.7 MW. HHFW plasmas typically have delivered P(subscript ''RF'') less than or equal to 3 MW. Important to the understanding of NSTX confinement are the new kinetic profile diagnostics: a multi-pulse Thomson scattering system (MPTS) and a charge-exchange recombination spectroscopy (CHERS) system. The MPTS diagnostic currently measures electron density and temperature profiles at 30 Hz at ten spatial locations. The CHERS system has recently become available to measure carbon ion temperature and toroidal flow at 17 radial positions spanning the outer half of the minor radius with 20 msec time resolution during NBI. Experiments conducted during the last year have produced a wide range of kinetic profiles in NSTX. Some interesting examples are presented below

  19. Transition Funding for the Shallow Water Integrated Mapping System SWIMS and Modular Microstructure Profiler MMP

    Science.gov (United States)

    2013-09-30

    the performance of operational and climate models, as well as for understanding local problems such as pollutant dispersal and biological...Mapping System (SWIMS) and Modular Microstructure Profiler (MMP) Matthew H. Alford Applied Physics Laboratory 1013 NE 40th Street Seattle, WA...in Juan de Fuca Submarine Canyon . Measurements were successful. In the next few weeks we will be testing MMP from our local work boat, the R/V Jack

  20. Road profile estimation of city roads using DTPS

    Science.gov (United States)

    Wang, Qi; McDaniel, J. Gregory; Sun, Nian X.; Wang, Ming L.

    2013-04-01

    This work presents a non-destructive and non-contact acoustic sensing approach for measuring road profile of road and bridge deck with vehicles running at normal speed without stopping traffic. This approach uses an instantaneous and real-time dynamic tire pressure sensor (DTPS) that can measure dynamic response of the tire-road interaction and increases the efficiency of currently used road profile measuring systems with vehicle body-mounted profilers and axle-mounted accelerometers. In this work, a prototype of real-time DTPS system has been developed and demonstrated on a testing van at speeds from 5 to 80 miles per hour (mph). A data analysis algorithm has been developed to remove axle dynamic motions from the measured DTPS data and to find the transfer function between dynamic tire pressure change and the road profile. Field test has been performed to estimate road profiles. The road profile resolution is approximately 5 to 10 cm in width and sensitivity is 0. 3 cm for the height road surface features at driving speeds of 5 to 80 mph.

  1. Measurement of whole tire profile

    Science.gov (United States)

    Yang, Yongyue; Jiao, Wenguang

    2010-08-01

    In this paper, a precision measuring device is developed for obtaining characteristic curve of tire profile and its geometric parameters. It consists of a laser displacement measurement unit, a closed-loop precision two-dimensional coordinate table, a step motor control system and a fast data acquisition and analysis system. Based on the laser trigonometry, a data map of tire profile and coordinate values of all points can be obtained through corresponding data transformation. This device has a compact structure, a convenient control, a simple hardware circuit design and a high measurement precision. Experimental results indicate that measurement precision can meet the customer accuracy requirement of +/-0.02 mm.

  2. Protecting New Zealand children from exposure to the marketing of unhealthy foods and drinks: a comparison of three nutrient profiling systems to classify foods.

    Science.gov (United States)

    Mhurchu, Cliona Ni; Mackenzie, Tara; Vandevijvere, Stefanie

    2016-09-09

    Promotion of unhealthy foods and drinks is a significant, modifiable risk factor for child obesity and diet-related non-communicable diseases. We compared three accepted nutrient profiling systems: the Health Star Rating (HSR), the Ministry of Health Food and Beverage Classification System (FBCS) and the World Health Organization (WHO) Regional Office for Europe Nutrient Profiling Model, to identify the best system to protect New Zealand children from exposure to the marketing of unhealthy foods and beverages. 13,066 packaged foods from the 2014 New Zealand Nutritrack database were classified as 'restricted' or 'not restricted' as per the WHO model; 'everyday/sometimes' or 'occasional' as per the FBCS model; and 'foods that met the criteria for all three systems or none of the systems, and the types of food products classified as 'restricted' under the WHO model but classified as 'everyday/sometimes' (FBCS model) or as having >3.5 stars, were determined. Under any of the three nutrient profiling systems, approximately one-third (29-39%) of New Zealand packaged foods would be permitted to be marketed to children. The WHO Model would permit marketing of 29% of products; the HSR system would permit 36%; and the FBCS system would permit 39%. The WHO Model restricts marketing of unhealthy foods more effectively than the other two systems. The HSR and FBCS systems would permit marketing of a number of food products of concern, particularly high-sugar breakfast cereals, fruit juices and ready meals. The WHO Regional Office for Europe Nutrient Profiling Model should underpin the Advertising Standards Authority revised Children's Code for Advertising Food. The effectiveness of the new Code in reducing New Zealand children's exposure to marketing of unhealthy foods and drinks should be subject to evaluation by an independent body.

  3. Virtual environment assessment for laser-based vision surface profiling

    Science.gov (United States)

    ElSoussi, Adnane; Al Alami, Abed ElRahman; Abu-Nabah, Bassam A.

    2015-03-01

    Oil and gas businesses have been raising the demand from original equipment manufacturers (OEMs) to implement a reliable metrology method in assessing surface profiles of welds before and after grinding. This certainly mandates the deviation from the commonly used surface measurement gauges, which are not only operator dependent, but also limited to discrete measurements along the weld. Due to its potential accuracy and speed, the use of laser-based vision surface profiling systems have been progressively rising as part of manufacturing quality control. This effort presents a virtual environment that lends itself for developing and evaluating existing laser vision sensor (LVS) calibration and measurement techniques. A combination of two known calibration techniques is implemented to deliver a calibrated LVS system. System calibration is implemented virtually and experimentally to scan simulated and 3D printed features of known profiles, respectively. Scanned data is inverted and compared with the input profiles to validate the virtual environment capability for LVS surface profiling and preliminary assess the measurement technique for weld profiling applications. Moreover, this effort brings 3D scanning capability a step closer towards robust quality control applications in a manufacturing environment.

  4. A Universal Velocity Dispersion Profile for Pressure Supported Systems: Evidence for MONDian Gravity across Seven Orders of Magnitude in Mass

    Energy Technology Data Exchange (ETDEWEB)

    Durazo, R.; Hernandez, X.; Sánchez, S. F. [Instituto de Astronomía, Universidad Nacional Autónoma de México, Apartado Postal 70-264 C.P. 04510 México D.F., México (Mexico); Sodi, B. Cervantes [Instituto de Radioastronomía y Astrofísica, Universidad Nacional Autónoma de México, Campus Morelia, A.P. 3-72, C.P. 58089 Michoacán, México (Mexico)

    2017-03-10

    For any MONDian extended theory of gravity where the rotation curves of spiral galaxies are explained through a change in physics rather than the hypothesis of dark matter, a generic dynamical behavior is expected for pressure supported systems: an outer flattening of the velocity dispersion profile occurring at a characteristic radius, where both the amplitude of this flat velocity dispersion and the radius at which it appears are predicted to show distinct scalings with the total mass of the system. By carefully analyzing the dynamics of globular clusters and elliptical galaxies, we are able to significantly extend the astronomical diversity of objects in which MONDian gravity has been tested, from spiral galaxies to the much larger mass range covered by pressure supported systems. We show that a universal projected velocity dispersion profile accurately describes various classes of pressure supported systems, and further, that the expectations of extended gravity are met across seven orders of magnitude in mass. These observed scalings are not expected under dark matter cosmology, and would require particular explanations tuned at the scales of each distinct astrophysical system.

  5. Evaluating availability and price of essential medicines in Boston area (Massachusetts, USA) using WHO/HAI methodology.

    Science.gov (United States)

    Sharma, Abhishek; Rorden, Lindsey; Ewen, Margaret; Laing, Richard

    2016-01-01

    Many patients even those with health insurance pay out-of-pocket for medicines. We investigated the availability and prices of essential medicines in the Boston area. Using the WHO/HAI methodology, availability and undiscounted price data for both originator brand (OB) and lowest price generic (LPG) equivalent versions of 25 essential medicines (14 prescription; 11 over-the-counter (OTC)) were obtained from 17 private pharmacies. The inclusion and prices of 26 essential medicines in seven pharmacy discount programs were also studied. The medicine prices were compared with international reference prices (IRPs). In surveyed pharmacies, the OB medicines were less available as compared to the generics. The OB and LPG versions of OTC medicines were 21.33 and 11.53 times the IRP, respectively. The median prices of prescription medicines were higher, with OB and LPG versions at 158.14 and 38.03 times the IRP, respectively. In studied pharmacy discount programs, the price ratios of surveyed medicines varied from 4.4-13.9. While noting the WHO target that consumers should pay no more than four times the IRPs, medicine prices were considerably higher in the Boston area. The prices for medicines included in the pharmacy discount programs were closest to WHO's target. Consumers should shop around, as medicine inclusion and prices vary across discount programs. In order for consumers to identify meaningful potential savings through comparison shopping, price transparency is needed.

  6. Preliminary stratigraphic and hydrogeologic cross sections and seismic profile of the Floridan aquifer system of Broward County, Florida

    Science.gov (United States)

    Reese, Ronald S.; Cunningham, Kevin J.

    2013-01-01

    To help water-resource managers evaluate the Floridan aquifer system (FAS) as an alternative water supply, the U.S. Geological Survey initiated a study, in cooperation with the Broward County Environmental Protection and Growth Management Department, to refine the hydrogeologic framework of the FAS in the eastern part of Broward County. This report presents three preliminary cross sections illustrating stratigraphy and hydrogeology in eastern Broward County as well as an interpreted seismic profile along one of the cross sections. Marker horizons were identified using borehole geophysical data and were initially used to perform well-to-well correlation. Core sample data were integrated with the borehole geophysical data to support stratigraphic and hydrogeologic interpretations of marker horizons. Stratigraphic and hydrogeologic units were correlated across the county using borehole geophysical data from multiple wells. Seismic-reflection data were collected along the Hillsboro Canal. Borehole geophysical data were used to identify and correlate hydrogeologic units in the seismic-reflection profile. Faults and collapse structures that intersect hydrogeologic units were also identified in the seismic profile. The information provided in the cross sections and the seismic profile is preliminary and subject to revision.

  7. Measurement system of bubbly flow using Ultrasonic Velocity Profile Monitor and Video Data Processing Unit. 3. Comparison of flow characteristics between bubbly cocurrent and countercurrent flows

    International Nuclear Information System (INIS)

    Zhou, Shirong; Suzuki, Yumiko; Aritomi, Masanori; Matsuzaki, Mitsuo; Takeda, Yasushi; Mori, Michitsugu

    1998-01-01

    The authors have developed a new measurement system which consisted of an Ultrasonic Velocity Profile Monitor (UVP) and a Video Data Processing Unit (VDP) in order to clarify the two-dimensional flow characteristics in bubbly flows and to offer a data base to validate numerical codes for two-dimensional two-phase flow. In the present paper, the proposed measurement system is applied to fully developed bubbly cocurrent flows in a vertical rectangular channel. At first, both bubble and water velocity profiles and void fraction profiles in the channel were investigated statistically. In addition, the two-phase multiplier profile of turbulence intensity, which was defined as a ratio of the standard deviation of velocity fluctuation in a bubbly flow to that in a water single phase flow, were examined. Next, these flow characteristics were compared with those in bubbly countercurrent flows reported in our previous paper. Finally, concerning the drift flux model, the distribution parameter and drift velocity were obtained directly from both bubble and water velocity profiles and void fraction profiles, and their results were compared with those in bubbly countercurrent flows. (author)

  8. Profiles and Context for Structured Text Retrieval

    DEFF Research Database (Denmark)

    Koolen, Marijn; Bogers, Toine

    2017-01-01

    The combination of structured information retrieval with user profile information represents the scenario where systems search with an explicit statement of the information need—a search query—as well as a profile of a user, which can contain information about previous interactions, search histor...

  9. Architecture oriented modeling and simulation method for combat mission profile

    Directory of Open Access Journals (Sweden)

    CHEN Xia

    2017-05-01

    Full Text Available In order to effectively analyze the system behavior and system performance of combat mission profile, an architecture-oriented modeling and simulation method is proposed. Starting from the architecture modeling,this paper describes the mission profile based on the definition from National Military Standard of China and the US Department of Defense Architecture Framework(DoDAFmodel, and constructs the architecture model of the mission profile. Then the transformation relationship between the architecture model and the agent simulation model is proposed to form the mission profile executable model. At last,taking the air-defense mission profile as an example,the agent simulation model is established based on the architecture model,and the input and output relations of the simulation model are analyzed. It provides method guidance for the combat mission profile design.

  10. {sup 1}H NMR-based metabolic profiling reveals inherent biological variation in yeast and nematode model systems

    Energy Technology Data Exchange (ETDEWEB)

    Szeto, Samuel S. W.; Reinke, Stacey N.; Lemire, Bernard D., E-mail: bernard.lemire@ualberta.ca [University of Alberta, Department of Biochemistry, School of Molecular and Systems Medicine (Canada)

    2011-04-15

    The application of metabolomics to human and animal model systems is poised to provide great insight into our understanding of disease etiology and the metabolic changes that are associated with these conditions. However, metabolomic studies have also revealed that there is significant, inherent biological variation in human samples and even in samples from animal model systems where the animals are housed under carefully controlled conditions. This inherent biological variability is an important consideration for all metabolomics analyses. In this study, we examined the biological variation in {sup 1}H NMR-based metabolic profiling of two model systems, the yeast Saccharomyces cerevisiae and the nematode Caenorhabditis elegans. Using relative standard deviations (RSD) as a measure of variability, our results reveal that both model systems have significant amounts of biological variation. The C. elegans metabolome possesses greater metabolic variance with average RSD values of 29 and 39%, depending on the food source that was used. The S. cerevisiae exometabolome RSD values ranged from 8% to 12% for the four strains examined. We also determined whether biological variation occurs between pairs of phenotypically identical yeast strains. Multivariate statistical analysis allowed us to discriminate between pair members based on their metabolic phenotypes. Our results highlight the variability of the metabolome that exists even for less complex model systems cultured under defined conditions. We also highlight the efficacy of metabolic profiling for defining these subtle metabolic alterations.

  11. Load profiles analysis for electricity market

    Directory of Open Access Journals (Sweden)

    Radu Porumb

    2014-04-01

    Full Text Available In the wake of electric power system transition towards smart grids, and the adoption of the electric market schemes, electric utilities are facing the need of a better load profiles understanding for their customers. In this work, some key objectives were addresses, such as definition of the mathematical model for calculating the hourly energy specific, identification of the three target groups for users who have developed consumer profiles, definition of the two types of significant load and assessment of the impact of using consumer profiles on users.

  12. Coaxial Compound Helicopter for Confined Urban Operations

    Science.gov (United States)

    2016-01-22

    weight empty by almost 300 lb. ITEP Engine The Improved Turbine Engine Program (ITEP) is developing the technology for a 3000 hp-class engine (Ref...ground effect IADS Integrated Air Defense Systems 13 IRP intermediate rated power ISA International Standard Atmosphere ITEP Improved Turbine ...marinization 7.9 hydraulic group 64.0 0.712 pressurization 7.9 0.880 electrical group 399.0 crashworthiness 39.0 0.850

  13. Simulation of Profiles Data For Computed Tomography Using Object Images

    International Nuclear Information System (INIS)

    Srisatit, Somyot

    2007-08-01

    Full text: It is necessary to use a scanning system to obtain the profiles data for computed tomographic images. A good profile data can give a good contrast and resolution. For the scanning system, high efficiency and high price of radiation equipments must be used. So, the simulated profiles data to obtain a good CT images quality as same as the real one for the demonstration can be used

  14. Gene Expression Profiling of Peripheral Blood From Kidney Transplant Recipients for the Early Detection of Digestive System Cancer.

    Science.gov (United States)

    Kusaka, M; Okamoto, M; Takenaka, M; Sasaki, H; Fukami, N; Kataoka, K; Ito, T; Kenmochi, T; Hoshinaga, K; Shiroki, R

    2017-06-01

    Kidney transplant recipients are at increased risk of developing cancer in comparison with the general population. To effectively manage post-transplantation malignancies, it is essential to proactively monitor patients. A long-term intensive screening program was associated with a reduced incidence of cancer after transplantation. This study evaluated the usefulness of the gene expression profiling of peripheral blood samples obtained from kidney transplant patients and adopted a screening test for detecting cancer of the digestive system (gastric, colon, pancreas, and biliary tract). Nineteen patients were included in this study and a total of 53 gene expression screening tests were performed. The gene expression profiles of blood-delivered total RNA and whole genome human gene expression profiles were obtained. We investigated the expression levels of 2665 genes associated with digestive cancers and counted the number of genes in which expression was altered. A hierarchical clustering analysis was also performed. The final prediction of the cancer possibility was determined according to an algorithm. The number of genes in which expression was altered was significantly increased in the kidney transplant recipients in comparison with the general population (1091 ± 63 vs 823 ± 94; P = .0024). The number of genes with altered expression decreased after the induction of mechanistic target of rapamycin (mTOR) inhibitor (1484 ± 227 vs 883 ± 154; P = .0439). No cases of possible digestive cancer were detected in this study period. The gene expression profiling of peripheral blood samples may be a useful and noninvasive diagnostic tool that allows for the early detection of cancer of the digestive system. Copyright © 2017 Elsevier Inc. All rights reserved.

  15. Implementation of reflectometry as a standard density profile diagnostic on DIII-D

    International Nuclear Information System (INIS)

    Zeng, L.; Doyle, E. J.; Luce, T. C.; Peebles, W. A.

    2001-01-01

    The profile reflectometer system on the DIII-D tokamak has been significantly upgraded in order to improve time coverage, data quality, and profile availability. The performance of the reflectometer system, which utilizes continuous frequency modulated (FMCW) radar techniques, has been improved as follows: First, a new PC-based data acquisition system has been installed, providing higher data sampling rates and larger memory depth. The higher sampling rate enables use of faster frequency sweeps of the FMCW microwave source, improving time resolution, and increasing profile accuracy. The larger memory depth enables longer data records, so that profiles can now be obtained throughout 5 s discharges at 100 Hz profile measurement rates, while continuous sampling at 10 MHz is available for 1 s for high time resolution physics studies. Second, an initial automated between-shots profile analysis capability is now available. Third, availability of the profiles to end users has been significantly improved

  16. Applicability analysis of hexahedral hollow profiles as component elements of supporting systems for gondola cars

    Directory of Open Access Journals (Sweden)

    O. V. Fomin

    2014-12-01

    Full Text Available Purpose. The purpose of work is presentation of features and results of the conducted works on determination of introduction expedience of hexahedral hollow profiles as the component elements of the modern supporting systems of railway freight gondola cars. Methodology. During the research an introduction methodology of different types of profiles as alternative to the existent supporting elements of the body module for freight car was used. This methodology had been developed by the author before. It is oriented to the reduction in material consumption and providing of strength requirements and operating reliability of the car design under study. The developed methodology includes the procedures of admissible values calculation of the resistance moments of the section of the hexahedral hollow profile, which is being introduced. It also includes the determination of optimum (i.e. characterized by the minimum material consumption when meeting the durability requirements values of height and minimum thickness of profile in the conditions of construction limitations. At the same time the admissible resistance moments are calculated as such, which are equal to the value of existent implementation of supporting element or as such that are determined taking into account the surplus design reserve. The first direction is applied in this work. Findings. As a result of the conducted research the introduction expedience of hexahedral hollow profiles as vertical rods of the lateral and latitude belts of the walls of the butt-end freight gondola cars is grounded and the optimum parameters of such replacements are determined. Originality. The problem of the use expedience of hexahedral hollow profiles as the supporting elements of the freight gondola cars bodies was first considered in the article. To solve this problem the mathematical models describing the dependence of basic strength and mass indexes of the proper profiles on varying the geometrical

  17. Intelligent routing protocol for ad hoc wireless network

    Science.gov (United States)

    Peng, Chaorong; Chen, Chang Wen

    2006-05-01

    A novel routing scheme for mobile ad hoc networks (MANETs), which combines hybrid and multi-inter-routing path properties with a distributed topology discovery route mechanism using control agents is proposed in this paper. In recent years, a variety of hybrid routing protocols for Mobile Ad hoc wireless networks (MANETs) have been developed. Which is proactively maintains routing information for a local neighborhood, while reactively acquiring routes to destinations beyond the global. The hybrid protocol reduces routing discovery latency and the end-to-end delay by providing high connectivity without requiring much of the scarce network capacity. On the other side the hybrid routing protocols in MANETs likes Zone Routing Protocol still need route "re-discover" time when a route between zones link break. Sine the topology update information needs to be broadcast routing request on local zone. Due to this delay, the routing protocol may not be applicable for real-time data and multimedia communication. We utilize the advantages of a clustering organization and multi-routing path in routing protocol to achieve several goals at the same time. Firstly, IRP efficiently saves network bandwidth and reduces route reconstruction time when a routing path fails. The IRP protocol does not require global periodic routing advertisements, local control agents will automatically monitor and repair broke links. Secondly, it efficiently reduces congestion and traffic "bottlenecks" for ClusterHeads in clustering network. Thirdly, it reduces significant overheads associated with maintaining clusters. Fourthly, it improves clusters stability due to dynamic topology changing frequently. In this paper, we present the Intelligent Routing Protocol. First, we discuss the problem of routing in ad hoc networks and the motivation of IRP. We describe the hierarchical architecture of IRP. We describe the routing process and illustrate it with an example. Further, we describe the control manage

  18. Simple laser vision sensor calibration for surface profiling applications

    Science.gov (United States)

    Abu-Nabah, Bassam A.; ElSoussi, Adnane O.; Al Alami, Abed ElRahman K.

    2016-09-01

    Due to the relatively large structures in the Oil and Gas industry, original equipment manufacturers (OEMs) have been implementing custom-designed laser vision sensor (LVS) surface profiling systems as part of quality control in their manufacturing processes. The rough manufacturing environment and the continuous movement and misalignment of these custom-designed tools adversely affect the accuracy of laser-based vision surface profiling applications. Accordingly, Oil and Gas businesses have been raising the demand from the OEMs to implement practical and robust LVS calibration techniques prior to running any visual inspections. This effort introduces an LVS calibration technique representing a simplified version of two known calibration techniques, which are commonly implemented to obtain a calibrated LVS system for surface profiling applications. Both calibration techniques are implemented virtually and experimentally to scan simulated and three-dimensional (3D) printed features of known profiles, respectively. Scanned data is transformed from the camera frame to points in the world coordinate system and compared with the input profiles to validate the introduced calibration technique capability against the more complex approach and preliminarily assess the measurement technique for weld profiling applications. Moreover, the sensitivity to stand-off distances is analyzed to illustrate the practicality of the presented technique.

  19. Optimizing the e-beam profile of a single carbon nanotube field emission device for electric propulsion systems

    Directory of Open Access Journals (Sweden)

    Juliano Fujioka Mologni

    2010-04-01

    Full Text Available Preliminary studies on field emission (FE arrays comprised of carbon nanotubes (CNT as an electron source for electric propulsion system show remarkably promising results. Design parameters for a carbon nanotube (CNT field-emission device operating on triode configuration were numerically simulated and optimized in order to enhance the e-beam focusing quality. An additional focus gate (FG was integrated to the device to control the profile of the emitted e-beam. An axisymmetric finite element model was developed to calculate the electric field distribution on the vacuum region and a modified Fowler-Nordheim (FN equation was used to evaluate the current density emission and the effective emitter area. Afterward, a FE simulation was employed in order to calculate the trajectory of the emitted electrons and define the electron-optical properties of the e-beam. The integration of the FG was fully investigated via computational intelligence techniques. The best performance device according to our simulations presents a collimated e-beam profile that suits well for field emission displays, magnetic field detection and electron microscopy. The automated computational design tool presented in this study strongly benefits the robust design of integrated electron-optical systems for vacuum field emission applications, including electrodynamic tethering and electric propulsion systems.

  20. Cardiac Autonomic Nervous System Activation and Metabolic Profile in Young Children: The ABCD Study.

    Directory of Open Access Journals (Sweden)

    Tanja G M Vrijkotte

    Full Text Available In adults, increased sympathetic and decreased parasympathetic nervous system activity are associated with a less favorable metabolic profile. Whether this is already determined at early age is unknown. Therefore, we aimed to assess the association between autonomic nervous system activation and metabolic profile and its components in children at age of 5-6 years.Cross-sectional data from an apparently healthy population (within the ABCD study were collected at age 5-6 years in 1540 children. Heart rate (HR, respiratory sinus arrhythmia (RSA; parasympathetic activity and pre-ejection period (PEP; sympathetic activity were assessed during rest. Metabolic components were waist-height ratio (WHtR, systolic blood pressure (SBP, fasting triglycerides, glucose and HDL-cholesterol. Individual components, as well as a cumulative metabolic score, were analyzed.In analysis adjusted for child's physical activity, sleep, anxiety score and other potential confounders, increased HR and decreased RSA were associated with higher WHtR (P< 0.01, higher SBP (p<0.001 and a higher cumulative metabolic score (HR: p < 0.001; RSA: p < 0.01. Lower PEP was only associated with higher SBP (p <0.05. Of all children, 5.6% had 3 or more (out of 5 adverse metabolic components; only higher HR was associated with this risk (per 10 bpm increase: OR = 1.56; p < 0.001.This study shows that decreased parasympathetic activity is associated with central adiposity and higher SBP, indicative of increased metabolic risk, already at age 5-6 years.

  1. Site-selective dopant profiling of p-n junction specimens in the dual-beam FIB/SEM system

    International Nuclear Information System (INIS)

    Chee, K W A; Beanland, R; Midgley, P A; Humphreys, C J

    2010-01-01

    Results from site-specific dopant profiling in a dual-beam FIB/SEM system are reported. Si specimens containing p-n junctions were milled using Ga + ion beam energies ranging from 30 keV to 2 keV, and analysed in situin the vacuum chamber. We compare the dopant contrast observed when milling a cleaved surface to that obtained from a side-wall of a trench cut using 30 kV Ga + ions, and using successively lower ion beam energies. The latter technique is suitable for site-specific dopant profiling. We find that lower energy ion beam milling significantly improves contrast, but only achieves 50 % of that observed on a freshly-cleaved surface. Furthermore, the contrast on a side-wall previously milled using high energy Ga + ions is less than that of a cleaved surface subjected to the same ion beam energy.

  2. Profile of the appendectomies performed in the Brazilian Public Health System

    Directory of Open Access Journals (Sweden)

    FERNANDA DOS SANTOS

    Full Text Available ABSTRACT Objective: to analyze the profile of appendectomies performed in the Brazilian Public Health System (SUS and to compare the laparoscopic and laparotomic techniques of appendectomy. Methods: This work used information from DataSus from 2008 to 2014 (http://datasus.saude.gov.br. We compared the data of patients submitted to laparotomic appendectomy with those submitted to laparoscopic one. Results: when comparing the total growth of appendectomies, the laparoscopic route increased 279.7%, while the increase in laparotomic surgery was 25% (p <0.001 in the study period. With regard to medical and hospital costs, laparoscopic appendectomy accounted for only 2.6% of the total expenditure on appendectomies performed by the Unified Health System (SUS hospitals, with an average cost 7.6% lower than that of laparotomy procedures, but without statistical significance. The mortality rate was 57.1% lower in the laparoscopic approach when compared with laparotomy. Conclusion: there has been a significant increase in the laparoscopic route in the treatment of appendicitis, but the method is still rarely used in SUS patients. The costs of laparoscopic appendectomy were similar to those observed in laparotomic access.

  3. Petroleum software profiles

    International Nuclear Information System (INIS)

    Anon.

    1996-01-01

    A profile of twenty-two software packages designed for petroleum exploration and production was provided. Some focussed on the oil and gas engineering industry, and others on mapping systems containing well history files and well data summaries. Still other programs provided accounting systems designed to address the complexities of the oil and gas industry. The software packages reviewed were developed by some of the best-known groups involved in software development for the oil and gas industry, including among others, Geoquest, the Can Tek Group, Applied Terravision Systems Inc., Neotechnology Consultants Ltd., (12) OGCI Software Inc., Oracle Energy, Production Revenue Information Systems Management, Virtual Computing Services Ltd., and geoLogic Systems Ltd

  4. Migrating the facility profile information management system into the world wide web

    Energy Technology Data Exchange (ETDEWEB)

    Kero, R.E.; Swietlik, C.E.

    1994-09-01

    The Department of Energy - Office of Special Projects and Argonne National Laboratory (ANL), along with the Department of Energy - office of Scientific and Technical Information have previously designed and implemented the Environment, Safety and Health Facility Profile Information Management System (FPIMS) to facilitate greater efficiency in searching, analyzing and disseminating information found within environment, safety and health oversight documents. This information retrieval based system serves as a central repository for full-text electronic oversight documents, as well as a management planning and decision making tool that can assist in trend and root cause analyses. Continuous improvement of environment, safety and health programs are currently aided through this personal computer-based system by providing a means for the open communication of lessons learned across the department. Overall benefits have included reductions in costs and improvements in past information management capabilities. Access to the FPIMS has been possible historically through a headquarters-based local area network equipped with modems. Continued demand for greater accessibility of the system by remote DOE field offices and sites, in conjunction with the Secretary of Energy` s call for greater public accessibility to Department of Energy (DOE) information resources, has been the impetus to expand access through the use of Internet technologies. Therefore, the following paper will discuss reasons for migrating the FPIMS system into the World Wide Web (Web), various lessons learned from the FPIMS migration effort, as well as future plans for enhancing the Web-based FPIMS.

  5. Recovering the systemic redshift of galaxies from their Lyman-alpha line profile

    Science.gov (United States)

    Verhamme, A.; Garel, T.; Ventou, E.; Contini, T.; Bouché, N.; Herenz, E. C.; Richard, J.; Bacon, R.; Schmidt, K. B.; Maseda, M.; Marino, R. A.; Brinchmann, J.; Cantalupo, S.; Caruana, J.; Clément, B.; Diener, C.; Drake, A. B.; Hashimoto, T.; Inami, H.; Kerutt, J.; Kollatschny, W.; Leclercq, F.; Patrício, V.; Schaye, J.; Wisotzki, L.; Zabl, J.

    2018-04-01

    The Lyman alpha (Lyα) line of Hydrogen is a prominent feature in the spectra of star-forming galaxies, usually redshifted by a few hundreds of km s-1 compared to the systemic redshift. This large offset hampers follow-up surveys, galaxy pair statistics and correlations with quasar absorption lines when only Lyα is available. We propose diagnostics that can be used to recover the systemic redshift directly from the properties of the Lyα line profile. We use spectroscopic observations of Lyman-Alpha Emitters (LAEs) for which a precise measurement of the systemic redshift is available. Our sample contains 13 sources detected between z ≈ 3 and z ≈ 6 as part of various Multi Unit Spectroscopic Explorer (MUSE) Guaranteed Time Observations (GTO). We also include a compilation of spectroscopic Lyα data from the literature spanning a wide redshift range (z ≈ 0 - 8). First, restricting our analysis to double-peaked Lyα spectra, we find a tight correlation between the velocity offset of the red peak with respect to the systemic redshift, V_peak^red, and the separation of the peaks. Secondly, we find a correlation between V_peak^red and the full width at half maximum of the Lyα line. Fitting formulas, to estimate systemic redshifts of galaxies with an accuracy of ≤100 km s-1 when only the Lyα emission line is available, are given for the two methods.

  6. Pengembangan Sistem Pendukung Keputusan Permasalahan Inventory Routing Problem Pada Spbu Menggunakan Algoritma Ant Colony

    Directory of Open Access Journals (Sweden)

    Satria Nur Alam

    2012-09-01

    Full Text Available Seiring dengan bertambahnya jumlah kendaraan setiap tahun, akan mempengaruhi konsumsi bahan bakar yang dibutuhkan. Tingginya kebutuhan bahan bakar di Indonesia didominasi oleh jenis bahan bakar premium. Persentase konsumsi bahan bakar premium di daerah Jawa-Bali mencapai 59% dari kuota premium nasional. Besarnya persentase kebutuhan akan bahan bakar premium, menyebabkan manajemen distribusi menjadi hal krusial yang perlu ditingkatkan secara berkala. Depo yang berperan sebagai supplier terhadap retailer -yang dalam studi kasus ini adalah SPBU- diusulkan menerapkan model Vendor Managed Inventory (VMI, yaitu proses pengadaan barang dimana supplier mengelola inventori dari retailernya. VMI memiliki salah satu perencanaan yaitu Inventory Routing Problem (IRP, IRP merupakan suatu bentuk perencanaan berbasis vendor hasil perpaduan antara Inventory Management dengan Inventory Routing yang mengatur kuantitas pengiriman dan retailer mana yang harus dikunjungi dalam suatu waktu perencanaan dalam jangka waktu tertentu yang bersifat terbatas (finite planning horizon. Dengan hasil akhir berupa penjadwalan, perencanaan model IRP mempertimbangkan jarak supplier-retailer dan biaya stockout yang mungkin terjadi pada retailer, sehingga diharapkan pengiriman optimal dan tidak terjadi stockout pada pos-pos penjualan bahan bakar.

  7. Constructing a web recommender system using web usage mining and user’s profiles

    Directory of Open Access Journals (Sweden)

    T. Mombeini

    2014-12-01

    Full Text Available The World Wide Web is a great source of information, which is nowadays being widely used due to the availability of useful information changing, dynamically. However, the large number of webpages often confuses many users and it is hard for them to find information on their interests. Therefore, it is necessary to provide a system capable of guiding users towards their desired choices and services. Recommender systems search among a large collection of user interests and recommend those, which are likely to be favored the most by the user. Web usage mining was designed to function on web server records, which are included in user search results. Therefore, recommender servers use the web usage mining technique to predict users’ browsing patterns and recommend those patterns in the form of a suggestion list. In this article, a recommender system based on web usage mining phases (online and offline was proposed. In the offline phase, the first step is to analyze user access records to identify user sessions. Next, user profiles are built using data from server records based on the frequency of access to pages, the time spent by the user on each page and the date of page view. Date is of importance since it is more possible for users to request new pages more than old ones and old pages are less probable to be viewed, as users mostly look for new information. Following the creation of user profiles, users are categorized in clusters using the Fuzzy C-means clustering algorithm and S(c criterion based on their similarities. In the online phase, a neural network is offered to identify the suggested model while online suggestions are generated using the suggestion module for the active user. Search engines analyze suggestion lists based on rate of user interest in pages and page rank and finally suggest appropriate pages to the active user. Experiments show that the proposed method of predicting user recent requested pages has more accuracy and

  8. Lidar for Wind and Optical Turbulence Profiling

    Directory of Open Access Journals (Sweden)

    Fastig Shlomo

    2018-01-01

    Full Text Available A field campaign for the comparison investigation of systems to measure wind and optical turbulence profiles was conducted in northern Germany. The experimental effort was to compare the performance of the LIDAR, SODAR-RASS and ultrasonic anemometers for the measurement of the above mentioned atmospheric parameters. Soreq's LIDAR is a fiber laser based system demonstrator for the vertical profiling of the wind and turbulence, based on the correlation of aerosol density variations. It provides measurements up to 350m with 20m resolution.

  9. MODELLING AND VIBRATION ANALYSIS OF A ROAD PROFILE MEASURING SYSTEM

    Directory of Open Access Journals (Sweden)

    C. B. Patel

    2010-06-01

    Full Text Available During a vehicle development program, load data representing severe customer usage is required. The dilemma faced by a design engineer during the design process is that during the initial stage, only predicted loads estimated from historical targets are available, whereas the actual loads are available only at the fag end of the process. At the same time, changes required, if any, are easier and inexpensive during the initial stages of the design process whereas they are extremely costly in the latter stages of the process. The use of road profiles and vehicle models to predict the load acting on the whole vehicle is currently being researched. This work hinges on the ability to accurately measure road profiles. The objective of the work is to develop an algorithm, using MATLAB Simulink software, to convert the input signals into measured road profile. The algorithm is checked by the MATLAB Simulink 4 degrees of freedom half car model. To make the whole Simulink model more realistic, accelerometer and laser sensor properties are introduced. The present work contains the simulation of the mentioned algorithm with a half car model and studies the results in distance, time, and the frequency domain.

  10. Individual Profiling Using Text Analysis

    Science.gov (United States)

    2016-04-15

    AFRL-AFOSR-UK-TR-2016-0011 Individual Profiling using Text Analysis 140333 Mark Stevenson UNIVERSITY OF SHEFFIELD, DEPARTMENT OF PSYCHOLOGY Final...REPORT TYPE      Final 3.  DATES COVERED (From - To)      15 Sep 2014 to 14 Sep 2015 4.  TITLE AND SUBTITLE Individual Profiling using Text Analysis ...consisted of collections of tweets for a number of Twitter users whose gender, age and personality scores are known. The task was to construct some system

  11. Low-level profiling and MARTE-compatible modeling of software components for real-time systems

    NARCIS (Netherlands)

    Triantafyllidis, K.; Bondarev, E.; With, de P.H.N.

    2012-01-01

    In this paper, we present a method for (a) profiling of individual components at high accuracy level, (b) modeling of the components with the accurate data obtained from profiling, and (c) model conversion to the MARTE profile. The resulting performance models of individual components are used at

  12. Tailoring double Fano profiles with plasmon-assisted quantum interference in hybrid exciton-plasmon system

    International Nuclear Information System (INIS)

    Zhao, Dongxing; Wu, Jiarui; Gu, Ying; Gong, Qihuang

    2014-01-01

    We propose tailoring of the double Fano profiles via plasmon-assisted quantum interference in a hybrid exciton-plasmon system. Tailoring is performed by the interference between two exciton channels interacting with a common localized surface plasmon. Using an applied field of low intensity, the absorption spectrum of the hybrid system reveals a double Fano lineshape with four peaks. For relatively large field intensity, a broad flat window in the absorption spectrum appears which results from the destructive interference between excitons. Because of strong constructive interference, this window vanishes as intensity is further increased. We have designed a nanometer bandpass optical filter for visible light based on tailoring of the optical spectrum. This study provides a platform for quantum interference that may have potential applications in ultracompact tunable quantum devices.

  13. Detecting and classifying method based on similarity matching of Android malware behavior with profile.

    Science.gov (United States)

    Jang, Jae-Wook; Yun, Jaesung; Mohaisen, Aziz; Woo, Jiyoung; Kim, Huy Kang

    2016-01-01

    Mass-market mobile security threats have increased recently due to the growth of mobile technologies and the popularity of mobile devices. Accordingly, techniques have been introduced for identifying, classifying, and defending against mobile threats utilizing static, dynamic, on-device, and off-device techniques. Static techniques are easy to evade, while dynamic techniques are expensive. On-device techniques are evasion, while off-device techniques need being always online. To address some of those shortcomings, we introduce Andro-profiler, a hybrid behavior based analysis and classification system for mobile malware. Andro-profiler main goals are efficiency, scalability, and accuracy. For that, Andro-profiler classifies malware by exploiting the behavior profiling extracted from the integrated system logs including system calls. Andro-profiler executes a malicious application on an emulator in order to generate the integrated system logs, and creates human-readable behavior profiles by analyzing the integrated system logs. By comparing the behavior profile of malicious application with representative behavior profile for each malware family using a weighted similarity matching technique, Andro-profiler detects and classifies it into malware families. The experiment results demonstrate that Andro-profiler is scalable, performs well in detecting and classifying malware with accuracy greater than 98 %, outperforms the existing state-of-the-art work, and is capable of identifying 0-day mobile malware samples.

  14. Effects of flaxseed consumption on systemic inflammation and serum lipid profile in hemodialysis patients with lipid abnormalities.

    Science.gov (United States)

    Khalatbari Soltani, Saman; Jamaluddin, Rosita; Tabibi, Hadi; Mohd Yusof, Barakatun Nisak; Atabak, Shahnaz; Loh, Su-Peng; Rahmani, Leila

    2013-04-01

    Inflammation and lipid abnormalities are two important risk factors for cardiovascular disease in hemodialysis (HD) patients. The present study was designed to investigate the effects of flaxseed consumption on systemic inflammation and serum lipid profile in HD patients with lipid abnormalities. This was an unblinded, randomized clinical trial. Thirty HD patients with dyslipidemia (triglyceride >200 mg/dL and/or high-density lipoprotein-cholesterol (HDL-C) consumption improves lipid abnormalities and reduces systemic inflammation in HD patients with lipid abnormalities. © 2012 The Authors. Hemodialysis International © 2012 International Society for Hemodialysis.

  15. Siderophore-mediated iron trafficking in humans is regulated by iron

    Science.gov (United States)

    Liu, Zhuoming; Lanford, Robert; Mueller, Sebastian; Gerhard, Glenn S.; Luscieti, Sara; Sanchez, Mayka; Devireddy, L.

    2013-01-01

    Siderophores are best known as small iron binding molecules that facilitate microbial iron transport. In our previous study we identified a siderophore-like molecule in mammalian cells and found that its biogenesis is evolutionarily conserved. A member of the short chain dehydrogenase family of reductases, 3-OH butyrate dehydrogenase (BDH2) catalyzes a rate-limiting step in the biogenesis of the mammalian siderophore. We have shown that depletion of the mammalian siderophore by inhibiting expression of bdh2 results in abnormal accumulation of cellular iron and mitochondrial iron deficiency. These observations suggest that the mammalian siderophore is a critical regulator of cellular iron homeostasis and facilitates mitochondrial iron import. By utilizing bioinformatics, we identified an iron-responsive element (IRE; a stem-loop structure that regulates genes expression post-transcriptionally upon binding to iron regulatory proteins or IRPs) in the 3′-untranslated region (3′-UTR) of the human BDH2 (hBDH2) gene. In cultured cells as well as in patient samples we now demonstrate that the IRE confers iron-dependent regulation on hBDH2 and binds IRPs in RNA electrophoretic mobility shift assays. In addition, we show that the hBDH2 IRE associates with IRPs in cells and that abrogation of IRPs by RNAi eliminates the iron-dependent regulation of hBDH2 mRNA. The key physiologic implication is that iron-mediated post-transcriptional regulation of hBDH2 controls mitochondrial iron homeostasis in human cells. These observations provide a new and an unanticipated mechanism by which iron regulates its intracellular trafficking. PMID:22527885

  16. Surface, segregation profile for Ni50Pd50(100)

    DEFF Research Database (Denmark)

    Christensen, Asbjørn; Ruban, Andrei; Skriver, Hans Lomholt

    1997-01-01

    A recent dynamical LEED study [G.N. Derry, C.B. McVey, P.J. Rous, Surf. Sci. 326 (1995) 59] reported an oscillatory surface segregation profile in the Ni50Pd50(100) system with the surface layer enriched by Pd. We have performed ab-initio total-energy calculations for the surface of this alloy...... system using the coherent potential approximation and obtain an oscillatory segregation profile, in agreement with experiments. We discuss the energetic origin of the oscillatory segregation profile in terms of effective cluster interactions. We include relaxation effects by means of the semi...

  17. On the Evaluation of Entity Profiles

    DEFF Research Database (Denmark)

    de Rijke, Maarten; Balog, Krisztian; Bogers, Toine

    be assessed by means of precision and recall values of the descriptive terms produced. However, recent evidence suggests that more sophisticated metrics are needed that go beyond mere lexical matching of system-produced descriptors against a ground truth, allowing for graded relevance and rewarding diversity......Entity profiling is the task of identifying and ranking descriptions of a given entity. The task may be viewed as one where the descriptions being sought are terms that need to be selected from a knowledge source (such as an ontology or thesaurus). In this case, entity profiling systems can...... in the list of descriptors returned. In this note, we motivate and propose such a metric....

  18. Sub-millisecond electron density profile measurement at the JET tokamak with the fast lithium beam emission spectroscopy system

    Science.gov (United States)

    Réfy, D. I.; Brix, M.; Gomes, R.; Tál, B.; Zoletnik, S.; Dunai, D.; Kocsis, G.; Kálvin, S.; Szabolics, T.; JET Contributors

    2018-04-01

    Diagnostic alkali atom (e.g., lithium) beams are routinely used to diagnose magnetically confined plasmas, namely, to measure the plasma electron density profile in the edge and the scrape off layer region. A light splitting optics system was installed into the observation system of the lithium beam emission spectroscopy diagnostic at the Joint European Torus (JET) tokamak, which allows simultaneous measurement of the beam light emission with a spectrometer and a fast avalanche photodiode (APD) camera. The spectrometer measurement allows density profile reconstruction with ˜10 ms time resolution, absolute position calculation from the Doppler shift, spectral background subtraction as well as relative intensity calibration of the channels for each discharge. The APD system is capable of measuring light intensities on the microsecond time scale. However ˜100 μs integration is needed to have an acceptable signal to noise ratio due to moderate light levels. Fast modulation of the beam up to 30 kHz is implemented which allows background subtraction on the 100 μs time scale. The measurement covers the 0.9 background subtraction, the relative calibration, and the comprehensive error calculation, runs a Bayesian density reconstruction code, and loads results to the JET database. The paper demonstrates the capability of the APD system by analyzing fast phenomena like pellet injection and edge localized modes.

  19. A simple data base for identification of risk profiles

    Energy Technology Data Exchange (ETDEWEB)

    Munganahalli, D.

    1996-12-31

    Sedco Forex is a drilling contractor that operates approximately 80 rigs on land and offshore worldwide. The HSE management system developed by Sedco Forex is an effort to prevent accidents and minimize losses. An integral part of the HSE management system is establishing risk profiles and thereby minimizing risk and reducing loss exposures. Risk profiles are established based on accident reports, potential accident reports and other risk identification reports (RIR) like the Du Pont STOP system. A rig could fill in as many as 30 accident reports, 30 potential accident reports and 500 STOP cards each year. Statistics are important for an HSE management system, since they are indicators of success or failure of HSE systems. It is however difficult to establish risk profiles based on statistical information, unless tools are available at the rig site to aid with the analysis. Risk profiles are then used to identify important areas in the operation that may require specific attention to minimize the loss exposure. Programs to address the loss exposure can then be identified and implemented with either a local or corporate approach. In January 1995, Sedco Forex implemented a uniform HSE Database on all the rigs worldwide. In one year companywide, the HSE database would contain information on approximately 500 accident and potential accident reports, and 10,000 STOP cards. This paper demonstrates the salient features of the database and describes how it has helped in establishing key risk profiles. It also shows a recent example of how risk profiles have been established at the corporate level and used to identify the key contributing factors to hands and finger injuries. Based on this information, a campaign was launched to minimize the frequency of occurrence and associated loss attributed to hands and fingers accidents.

  20. English Teaching Profile (Provisional): Venezuela.

    Science.gov (United States)

    British Council, London (England). English Language and Literature Div.

    This profile of the English language teaching situation in Venezuela discusses the status of English in society and in the educational system. It also gives an account of Venezuelan political, economic, and social life. A description is given of the education system and reforms that have been proposed for nursery school through higher education.…

  1. Medicolegal aspects of iatrogenic root perforations

    DEFF Research Database (Denmark)

    Tsesis, I; Rosen, E; Bjørndal, L

    2014-01-01

    AIM: To retrospectively analyze the medico-legal aspects of iatrogenic root perforations (IRP) that occurred during endodontic treatments. METHODOLOGY: A comprehensive search in a professional liability insurance database was conducted to retrospectively identify cases of IRP following root canal...... treatment (p root perforation is a complication of root canal treatment and may result in tooth extraction...... and in legal actions against the treating practitioner. Mandibular molars are more prone to medico-legal claims related to root perforations. The patient should be informed of the risks during RCT and should get information on alternative treatments and their risks and prognosis...

  2. New dynamic NNORSY ozone profile climatology

    Science.gov (United States)

    Kaifel, A. K.; Felder, M.; Declercq, C.; Lambert, J.-C.

    2012-01-01

    Climatological ozone profile data are widely used as a-priori information for total ozone using DOAS type retrievals as well as for ozone profile retrieval using optimal estimation, for data assimilation or evaluation of 3-D chemistry-transport models and a lot of other applications in atmospheric sciences and remote sensing. For most applications it is important that the climatology represents not only long term mean values but also the links between ozone and dynamic input parameters. These dynamic input parameters should be easily accessible from auxiliary datasets or easily measureable, and obviously should have a high correlation with ozone. For ozone profile these parameters are mainly total ozone column and temperature profile data. This was the outcome of a user consultation carried out in the framework of developing a new, dynamic ozone profile climatology. The new ozone profile climatology is based on the Neural Network Ozone Retrieval System (NNORSY) widely used for ozone profile retrieval from UV and IR satellite sounder data. NNORSY allows implicit modelling of any non-linear correspondence between input parameters (predictors) and ozone profile target vector. This paper presents the approach, setup and validation of a new family of ozone profile climatologies with static as well as dynamic input parameters (total ozone and temperature profile). The neural network training relies on ozone profile measurement data of well known quality provided by ground based (ozonesondes) and satellite based (SAGE II, HALOE, and POAM-III) measurements over the years 1995-2007. In total, four different combinations (modes) for input parameters (date, geolocation, total ozone column and temperature profile) are available. The geophysical validation spans from pole to pole using independent ozonesonde, lidar and satellite data (ACE-FTS, AURA-MLS) for individual and time series comparisons as well as for analysing the vertical and meridian structure of different modes of

  3. Beam Profile Measurement with Flying Wires at the Fermilab Recycler Ring

    CERN Document Server

    Hu, Martin; Krider, John; Lorman, Eugene; Marchionni, Alberto; Pishchalnikov, Yu M; Pordes, Stephen; Slimmer, David; Wilson, Peter R; Zagel, James

    2005-01-01

    The Fermilab Recycler Ring is a high vacuum fixed energy antiproton storage ring with stochastic and electron cooling systems. Flying wires were installed at the Fermilab Recycler Ring for transverse beam profile measurement. The following note describes the system configuration, calibration and resolution of the flying wire system, as well as analysis of the transverse beam profile in the presence of both cooling systems.

  4. A performance study on three qPCR quantification kits and their compatibilities with the 6-dye DNA profiling systems.

    Science.gov (United States)

    Lin, Sze-Wah; Li, Christina; Ip, Stephen C Y

    2018-03-01

    DNA quantification plays an integral role in forensic DNA profiling. Not only does it estimate the total amount of amplifiable human autosomal and male DNA to ensure optimal amplification of target DNA for subsequent analysis, but also assesses the extraction efficiency and purity of the DNA extract. Latest DNA quantification systems even offer an estimate for the degree of DNA degradation in a sample. Here, we report the performance of three new generation qPCR kits, namely Investigator ® Quantiplex HYres Kit from QIAGEN, Quantifiler ® Trio DNA Quantification Kit from Applied Biosystems™, and PowerQuant ® System from Promega, and their compatibilities with three 6-dye DNA profiling systems. Our results have demonstrated that all three kits generate standard curves with satisfactory consistency and reproducibility, and are capable of screening out traces of male DNA in the presence of 30-fold excess of female DNA. They also exhibit a higher tolerance to PCR inhibition than Quantifiler ® Human DNA Quantification Kit from Applied Biosystems™ in autosomal DNA quantification. PowerQuant ® , as compared to Quantiplex HYres and Quantifiler ® Trio, shows a better precision for both autosomal and male DNA quantifications. Quantifiler ® Trio and PowerQuant ® in contrast to Quantiplex HYres offer better correlations with lower discrepancies between autosomal and male DNA quantification, and their additional degradation index features provide a detection platform for inhibited and/or degraded DNA template. Regarding the compatibility between these quantification and profiling systems: (1) both Quantifiler ® Trio and PowerQuant ® work well with GlobalFiler and Fusion 6C, allowing a fairly accurate prediction of their DNA typing results based on the quantification values; (2) Quantiplex HYres offers a fairly reliable IPC system for detecting any potential inhibitions on Investigator 24plex, whereas Quantifiler ® Trio and PowerQuant ® suit better for Global

  5. Beam profile measurement with flying wires at the Fermilab Recycler Ring

    Energy Technology Data Exchange (ETDEWEB)

    Carcagno, R.; Pishchalnikov, Yu.; Krider, J.; Hu, M.; Lorman, E.; Marchionni, A.; Pordes, S.; Wilson, P.; Zagel, J.; /Fermilab

    2005-05-01

    Flying wires were installed at the Fermilab Recycler Ring for transverse beam profile measurement for both proton and antiproton beams. The following note describes the system configuration, calibration and resolution of the flying wire system, interactions between the wires and the beam, as well as analysis of the transverse beam profile in the presence of a stochastic cooling system.

  6. Beam profile measurement with flying wires at the Fermilab Recycler Ring

    International Nuclear Information System (INIS)

    Carcagno, R.; Pishchalnikov, Yu.; Krider, J.; Hu, M.; Lorman, E.; Marchionni, A.; Pordes, S.; Wilson, P.; Zagel, J.

    2005-01-01

    Flying wires were installed at the Fermilab Recycler Ring for transverse beam profile measurement for both proton and antiproton beams. The following note describes the system configuration, calibration and resolution of the flying wire system, interactions between the wires and the beam, as well as analysis of the transverse beam profile in the presence of a stochastic cooling system

  7. Residential Consumption Scheduling Based on Dynamic User Profiling

    Science.gov (United States)

    Mangiatordi, Federica; Pallotti, Emiliano; Del Vecchio, Paolo; Capodiferro, Licia

    Deployment of household appliances and of electric vehicles raises the electricity demand in the residential areas and the impact of the building's electrical power. The variations of electricity consumption across the day, may affect both the design of the electrical generation facilities and the electricity bill, mainly when a dynamic pricing is applied. This paper focuses on an energy management system able to control the day-ahead electricity demand in a residential area, taking into account both the variability of the energy production costs and the profiling of the users. The user's behavior is dynamically profiled on the basis of the tasks performed during the previous days and of the tasks foreseen for the current day. Depending on the size and on the flexibility in time of the user tasks, home inhabitants are grouped in, one over N, energy profiles, using a k-means algorithm. For a fixed energy generation cost, each energy profile is associated to a different hourly energy cost. The goal is to identify any bad user profile and to make it pay a highest bill. A bad profile example is when a user applies a lot of consumption tasks and low flexibility in task reallocation time. The proposed energy management system automatically schedules the tasks, solving a multi-objective optimization problem based on an MPSO strategy. The goals, when identifying bad users profiles, are to reduce the peak to average ratio in energy demand, and to minimize the energy costs, promoting virtuous behaviors.

  8. English Language Teaching Profile: Sweden.

    Science.gov (United States)

    British Council, London (England). English-Teaching Information Centre.

    This profile in outline form of the English language teaching situation in Sweden discusses the role of English within Swedish society and within the Swedish educational system. The status of English as the principal foreign language since 1945 for use in business, the media and tourism is pointed out. The system of English instruction in the…

  9. A gamma beam profile imager for ELI-NP Gamma Beam System

    Science.gov (United States)

    Cardarelli, P.; Paternò, G.; Di Domenico, G.; Consoli, E.; Marziani, M.; Andreotti, M.; Evangelisti, F.; Squerzanti, S.; Gambaccini, M.; Albergo, S.; Cappello, G.; Tricomi, A.; Veltri, M.; Adriani, O.; Borgheresi, R.; Graziani, G.; Passaleva, G.; Serban, A.; Starodubtsev, O.; Variola, A.; Palumbo, L.

    2018-06-01

    The Gamma Beam System of ELI-Nuclear Physics is a high brilliance monochromatic gamma source based on the inverse Compton interaction between an intense high power laser and a bright electron beam with tunable energy. The source, currently being assembled in Magurele (Romania), is designed to provide a beam with tunable average energy ranging from 0.2 to 19.5 MeV, rms energy bandwidth down to 0.5% and flux of about 108 photons/s. The system includes a set of detectors for the diagnostic and complete characterization of the gamma beam. To evaluate the spatial distribution of the beam a gamma beam profile imager is required. For this purpose, a detector based on a scintillator target coupled to a CCD camera was designed and a prototype was tested at INFN-Ferrara laboratories. A set of analytical calculations and Monte Carlo simulations were carried out to optimize the imager design and evaluate the performance expected with ELI-NP gamma beam. In this work the design of the imager is described in detail, as well as the simulation tools used and the results obtained. The simulation parameters were tuned and cross-checked with the experimental measurements carried out on the assembled prototype using the beam from an x-ray tube.

  10. Proteomic profiling of Mycobacterium tuberculosis identifies nutrient-starvation-responsive toxin-antitoxin systems

    DEFF Research Database (Denmark)

    Albrethsen, Jakob; Agner, Jeppe; Piersma, Sander R

    2013-01-01

    In order to successfully enter the latent stage, Mycobacterium tuberculosis must adapt to conditions such as nutrient limitation and hypoxia. In vitro models that mimic latent infection are valuable tools for describing the changes in metabolism that occur when the bacterium exists in a non......-growing form. We used two complementary proteomic approaches, label-free LC-MS/MS analysis and two-dimensional difference gel electrophoresis, to determine the proteome profile of extracellular proteins from M. tuberculosis cultured under nutrient starvation. Through the label-free LC-MS/MS analysis......, significant differences in the overall metabolism during nutrient starvation were detected. Notably, members of the toxin-antitoxin systems were present in larger quantities in nutrient-starved cultures, supporting a role for these global modules as M. tuberculosis switches its metabolism into dormancy...

  11. Automatic drawing of the geologic profile of an underground mine based on COMGIS

    Institute of Scientific and Technical Information of China (English)

    Yin Jingqiu; Qiu Xinfa; Li Anbo; Lu Mingyue

    2011-01-01

    This paper introduces a method of building a prototype system of geologic profile auto-drawing. A .NET development platform and integrated environment was used along with a component based design, a B/S system model, and XML techniques. Knowledge rules for creating geologic profiles and generating virtual drilling data from existing bore data and expert, hand-drawn geologic profiles were acquired.Then a prototype system was established by utilizing the known knowledge rules, topological relationships, and semantic relationships among strata. This system has a friendly human-computer interface and can meet requirements of mutual queries between attribute and spatial data. The generated profile map is editable. This study provides a new powerful tool for underground mine work.

  12. Development of a profile scoring system for assessing the psychosocial situation of patients with chronic musculoskeletal pain

    Directory of Open Access Journals (Sweden)

    Nikaido T

    2017-08-01

    Full Text Available Takuya Nikaido,1 Shingo Fukuma,2,3 Takafumi Wakita,4 Miho Sekiguchi,1 Shoji Yabuki,1 Yoshihiro Onishi,5 Shunichi Fukuhara,2,3 Shin-ichi Konno1 On behalf of the profile scoring system for multilateral assessment of social factors in patients with chronic musculoskeletal pain study group 1Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, Fukushima, 2Department of Healthcare Epidemiology, Kyoto University, Graduate School of Medicine and Public Health, Kyoto, 3Center for Innovative Research for Communities and Clinical Excellence (CIRC2LE, Fukushima Medical University, Fukushima, 4Department of Sociology, Kansai University, Osaka, 5Institute for Health Outcomes and Process Evaluation Research (iHope International, Kyoto, Japan Abstract: Chronic pain is a manifestation of interactions among physical, psychological, and social conditions, but the latter two, that is, the nonphysical correlates of chronic pain, are only rarely measured. This study aimed to develop a profile scoring system for assessing the psychosocial situation of patients with chronic musculoskeletal pain. An expert panel chose social and psychological domains considered to be relevant to patients with chronic pain and wrote questions asking about each of those domains. The questionnaire was completed by 252 patients with chronic musculoskeletal pain. Factor analysis was used to select questionnaire items for each domain. Associations and interactions of pain severity and each domain score with pain-related quality of life (PRQOL were examined using linear regression models. Five domains were chosen: work, family, sleep, mental health, and PRQOL. Then, a total of 17 questions were created for the work, family, and sleep domains. Using the likelihood-ratio test, we found significant interactions with PRQOL in four pairs: severity–family, severity–mental, family–sleep, and work–mental. The association between pain severity and PRQOL was

  13. Implementation of fuzzy logic for mitigating conflicts of frequency containment control

    DEFF Research Database (Denmark)

    Rikos, Evangelos; Syed, Mazheruddin; Caerts, Chris

    2017-01-01

    Ever increasing shares of intermittent renewable energy sources (RES) in present and future power systems pose new challenges with regard to operation, particularly balance, frequency and voltage stability. Towards effective solutions, the ELECTRA IRP project has developed a novel structure...... imposed by different system conditions. To this end, a design method based on fuzzy logic for avoiding conflicts caused from these conditions or multiple control loops implemented on the same resource is proposed. Simulation results for various selected scenarios and controllers show the effectiveness...

  14. Morphometric synaptology of a whole neuron profile using a semiautomatic interactive computer system.

    Science.gov (United States)

    Saito, K; Niki, K

    1983-07-01

    We propose a new method of dealing with morphometric synaptology that processes all synapses and boutons around the HRP marked neuron on a large composite electron micrograph, rather than a qualitative or a piecemeal quantitative study of a particular synapse and/or bouton that is not positioned on the surface of the neuron. This approach requires the development of both neuroanatomical procedures, by which a specific whole neuronal profile is identified, and valuable specialized tools, which support the collection and analysis of a great volume of morphometric data from composite electron micrographs, in order to reduce the burden of the morphologist. The present report is also concerned with the total and reliable semi-automatic interactive computer system for gathering and analyzing morphometric data that has been under development in our laboratory. A morphologist performs the pattern recognition portion by using a large-sized tablet digitizer and a menu-sheet command, and the system registers the various morphometric values of many different neurons and performs statistical analysis. Some examples of morphometric measurements and analysis show the usefulness and efficiency of the proposed system and method.

  15. Ontology-Based User Profiling for Personalized Acces to Information within Collaborative Learning System

    Directory of Open Access Journals (Sweden)

    Mohammed Amine Alimam

    2014-06-01

    Full Text Available The use of modern educational technology methods has become an important area of research in order to support learning as well as collaboration. This is especially evident with the rise of internet and web 2.0 platforms that have transformed users’ role from mere content consumers to fully content consumers-producers. Furthermore, people engaged in collaborative learning capitalize on one another’s resources and skills, unlike individual learning. This paper proceeds with a categorization of the main tools and functions that characterize the personalization learning aspect, in order to discuss their trade-offs with collaborative learning systems. It proposes a framework of a personalized information research (IR within a collaborative learning system, incorporating the characterization of the research type carried by the query, as well as modeling and constructing semantic users’ profiles. We use the context of the user query into a prediction mechanism of the search type, based on a previous identification of users’ levels and interests. The paper is concluded by presenting experiment results, revealing that the use of the subject ontology extension approach satisfyingly contributes to improvement in the accuracy of system recommendations.

  16. First experiences of full-profile analysis with GUISDAP

    Directory of Open Access Journals (Sweden)

    M. S. Lehtinen

    Full Text Available In this paper we summarize the theory behind full-profile analysis of IS measurements and report first practical experiences with the GUISDAP (Grand Unified Incoherent Scatter Design and Analysis Package system designed to perform full-profile analysis of any IS measurements efficiently. By fitting whole plasma parameter profiles over the ionosphere, instead of point values of the parameters supposed to be approximately constant over small range intervals, full-profile analysis is free of underlying assumptions about the slow variation of the plasma parameters as a function of range. We define full-profile analysis as a mathematical inversion problem formalism and explain how it differs from the traditional gated analysis. Moreover, we study the bias introduced to traditional analysis results using realistic model ionospheres. By applying the full-profile method to data generated from the model ionospheres, we demonstrate that full-profile analysis is free from this kind of bias. Lastly, an example of analysis of real data by full-profile and gated analyses is shown.

  17. First experiences of full-profile analysis with GUISDAP

    Directory of Open Access Journals (Sweden)

    M. S. Lehtinen

    1996-12-01

    Full Text Available In this paper we summarize the theory behind full-profile analysis of IS measurements and report first practical experiences with the GUISDAP (Grand Unified Incoherent Scatter Design and Analysis Package system designed to perform full-profile analysis of any IS measurements efficiently. By fitting whole plasma parameter profiles over the ionosphere, instead of point values of the parameters supposed to be approximately constant over small range intervals, full-profile analysis is free of underlying assumptions about the slow variation of the plasma parameters as a function of range. We define full-profile analysis as a mathematical inversion problem formalism and explain how it differs from the traditional gated analysis. Moreover, we study the bias introduced to traditional analysis results using realistic model ionospheres. By applying the full-profile method to data generated from the model ionospheres, we demonstrate that full-profile analysis is free from this kind of bias. Lastly, an example of analysis of real data by full-profile and gated analyses is shown.

  18. The loaded surface profile: a new technique for the investigation of contact surfaces

    OpenAIRE

    McBride, J.W.

    2006-01-01

    Contact between rough surfaces produces a complex contact profile. The contact area is usually estimated according to roughness statistics in conjunction withsurface models or by examining the surfaces before and after contact. Most of the existing literature on loaded surface profiles is theoretical or numerical in nature. This paper presents a methodology for a new system to measure the loaded surface profile, based on a non-contact 3D laser profiler. The system allows the measurement of...

  19. Psychological profile: the problem of modeling the unknown criminal personality

    Directory of Open Access Journals (Sweden)

    Г. М. Гетьман

    2013-10-01

    Full Text Available The article investigates the problem of modeling an unknown person in the preparation of criminal psychological profile. Some approaches to the concept of "psychological profile" and "psychological portrait", in particular the proposed delineation of these terms. We consider the system steps in the development of the psychological profile of an unknown perpetrator.

  20. CAMEX-4 MIPS 915 MHZ DOPPLER WIND PROFILER V1

    Data.gov (United States)

    National Aeronautics and Space Administration — The CAMEX-4 MIPS 915 MHZ Doppler Wind Profiler dataset was collected by the University of Alabama in Huntsville (UAH) Mobile Integrated Profiling System (MIPS),...

  1. Core radial power profile effect on system and core cooling behavior during reflood phase of PWR-LOCA with CCTF data

    International Nuclear Information System (INIS)

    Akimoto, Hajime; Iguchi, Tadashi; Murao, Yoshio

    1985-01-01

    In the reactor safety assessment during reflood phase of a PWR-LOCA, it is assumed implicitly that the core thermal hydraulic behavior is evaluated by the one-dimensional model with an average power rod. In order to assess the applicability of the one-dimensional treatment, integral tests were performed with various core radial power profiles using the Cylindrical Core Test Facility (CCTF) whose core includes about 2,000 heater rods. The CCTF results confirm that the core radial power profile has weak effect on the thermal hydraulic behavior in the primary system except core. It is also confirmed that the core differential pressure in the axial direction is predicted by the one-dimensional core model with an average power rod even in the case with a steep radial power profile in the core. Even though the core heat transfer coefficient is dependent on the core radial power profile, it is found that the error of the peak clad surface temperature calculation is less than 15 K using the one-dimensional model in the CCTF tests. The CCTF results support the one-dimensional treatment assumed in the reactor safety assessment. (author)

  2. Advances in the density profile evaluation from broadband reflectometry on ASDEX upgrade

    International Nuclear Information System (INIS)

    Varela, P.; Manso, M.; Conway, G.

    2001-01-01

    The high temporal and spatial resolutions provided by broadband microwave reflectometry make it an attractive diagnostic technique to measure the density profile in fusion plasmas. However, great problems have been encountered due to the plasma turbulence that difficult, and sometimes prevent, the routine evaluation of density profiles. Advanced broadband systems employ ultra-fast sweeping in an attempt to perform the profile measurement in a time window smaller than the temporal scale of the main plasma fluctuations but this is not sufficient. Indeed, abrupt plasma movements and/or spatial turbulence always affect the reflectometry signals, as shown by numerical studies (with both one- and two-dimensional codes), for the case of ultra-fast sweeping and pulse radar systems. For this reason not only the system performance is important but the software tools also play a crucial role for reflectometry to become a standard density profile diagnostic. Here we present the recent advances towards automatic evaluation of density profiles from broadband reflectometry on ASDEX Upgrade. For regimes with moderate levels of plasma turbulence, density profiles are obtained from single reflectometry samples (temporal resolution of 20 μs), and for higher turbulence levels average profiles are obtained from bursts of ultra-fast (20 μs), closely spaced (10 μs) sweeps. This method improved the accuracy and reliability of density profiles, which can now be obtained automatically from the edge to the bulk plasma - using reflectometry alone - in most plasma regimes of ASDEX Upgrade. New data processing capability has been implemented that allows the profiles to be available to the end-users 10-12 minutes after each discharge. These developments were possible due to the flexibility and high performance of the control and data acquisition systems and to the large number of measurements that can be performed with the diagnostic during each discharge (720 profiles both on the low- and

  3. A predictable Java profile - rationale and implementations

    DEFF Research Database (Denmark)

    Søndergaard, Hans; Bøgholm, Thomas; Hansen, Rene Rydhof

    A Java profile suitable for development of high integrity embedded systems is presented. It is based on event handlers which are grouped in missions and equipped with respectively private handler memory and shared mission memory. This is a result of our previous work on developing a Java profile......, and is directly inspired by interactions with the Open Group on their on-going work on a safety critical Java profile (JSR-302). The main contribution is an arrangement of the class hierarchy such that the proposal is a generalization of Real-Time Specification for Java (RTSJ). A further contribution...

  4. Step Density Profiles in Localized Chains

    Science.gov (United States)

    De Roeck, Wojciech; Dhar, Abhishek; Huveneers, François; Schütz, Marius

    2017-06-01

    We consider two types of strongly disordered one-dimensional Hamiltonian systems coupled to baths (energy or particle reservoirs) at the boundaries: strongly disordered quantum spin chains and disordered classical harmonic oscillators. These systems are believed to exhibit localization, implying in particular that the conductivity decays exponentially in the chain length L. We ask however for the profile of the (very slowly) transported quantity in the steady state. We find that this profile is a step-function, jumping in the middle of the chain from the value set by the left bath to the value set by the right bath. This is confirmed by numerics on a disordered quantum spin chain of 9 spins and on much longer chains of harmonic oscillators. From theoretical arguments, we find that the width of the step grows not faster than √{L}, and we confirm this numerically for harmonic oscillators. In this case, we also observe a drastic breakdown of local equilibrium at the step, resulting in a heavily oscillating temperature profile.

  5. From the profile of position to the profile of competences in human talent management

    Directory of Open Access Journals (Sweden)

    Marianela Bermejo-Salmon

    2017-12-01

    Full Text Available The objective of this study was the application of a methodology for the making of a position profile by competences with a holistic approach from the position of school director or engineering career of enterprises of the Faculty of Enterprises Administration in the Higher Polytechnical School of Chimborazo of Ecuador. Theoretical and empirical methods were used such as: Dialectical and Historical Materialism as a method that allows to establish the didactic logic in treating processes, the Delphi method and the holistic and integrated approach and techniques used were: group work, direct observation, functional analysis, psychological tests and interviews. As result, the application of this methodology to integrate the position profile and profile of labor competences as a unique system and insert them to other contexts outside the Cuban frontier from its adequacy to the particularities that characterize the negotiation of the human talent in the selected place.

  6. FY 1997 Hanford telecommunication and informations system user profile, milestone IRM-097-003

    Energy Technology Data Exchange (ETDEWEB)

    Witherspoon, T.T.

    1997-09-22

    This document reports survey data collected from the U.S. Department of Energy, Richland Operations Office (DOE-RL), Project Hanford Management Contract (PHMC) companies, and the PHMC enterprise companies for purposes of characterizing the Hanford Local Area Network (HLAN) user profile. Telephone, radio, and pager data are also provided. The data reveal that job tasks of the 8,500 Hanford Site workers who use the HLAN are highly, if not completely, computer dependent. Employees use their computers as their pens and paper, calculators, drafting tables and communication devices. Fifty eight percent of the survey respondents predict 90 to 100% loss in productivity if they had no access to a computer. Additionally, 30% of the users felt they would have a 50 to 80% loss in productivity without computers; and more than 68 % use their computers between 4 and 8 hours per day. The profile also shows th at the software packages used most heavily are cc:Mail` the Windows version, Hanford Information, WordPerfece, Site Forms and Look-up. Use of Windows-based products is very high. Regarding the productivity tools that are seldom used, 49 % of the respondents say they ``never use`` the Hanford Help and Hints (HUH). The use of the external intemet by Hanford has shown a large increase. The survey indicates that users rate the intranet and the ability to access other sources of information as the fourth most important computer application. The Microsoft System Management Server (SMS 4) data show that more than 60% of the computers on the HLAN need replacement or upgrades to run the Windows 95 Operating System, which has been selected as the PHMC standard. Although data also show that 77% of the PHMC machines are running the current standard Windows for Workgroup version 3. 1 1, they do not have the memory and/or the hard disk space to upgrade to Windows 95. The survey results indicate that telephone system use is also high and regarded as a useful tool. Pager use is very high and

  7. GronUP: Groningen User Profiling : Notebook for PAN at CLEF 2016

    NARCIS (Netherlands)

    Busger op Vollenbroek, Mart; Carlotto, Talvany; Kreutz, Tim; Medvedeva, Masha; Pool, Chris; Bjerva, Johannes; Haagsma, Hessel; Nissim, Malvina; Balog, Krisztian; Cappellato, Linda; Ferro, Nicola; Macdonald, Craig

    We trained an SVM model on tweets to perform user profiling, in terms of gender and age, on non-Twitter social media data. The system exploits features that we deemed appropriate to profile authors on social media, and that do not characterise too closely the specific usage of Twitter. Our system

  8. Exopolysaccharide-associated protein sorting in environmental organisms: the PEP-CTERM/EpsH system. Application of a novel phylogenetic profiling heuristic

    Directory of Open Access Journals (Sweden)

    Ward Naomi

    2006-08-01

    Full Text Available Abstract Background Protein translocation to the proper cellular destination may be guided by various classes of sorting signals recognizable in the primary sequence. Detection in some genomes, but not others, may reveal sorting system components by comparison of the phylogenetic profile of the class of sorting signal to that of various protein families. Results We describe a short C-terminal homology domain, sporadically distributed in bacteria, with several key characteristics of protein sorting signals. The domain includes a near-invariant motif Pro-Glu-Pro (PEP. This possible recognition or processing site is followed by a predicted transmembrane helix and a cluster rich in basic amino acids. We designate this domain PEP-CTERM. It tends to occur multiple times in a genome if it occurs at all, with a median count of eight instances; Verrucomicrobium spinosum has sixty-five. PEP-CTERM-containing proteins generally contain an N-terminal signal peptide and exhibit high diversity and little homology to known proteins. All bacteria with PEP-CTERM have both an outer membrane and exopolysaccharide (EPS production genes. By a simple heuristic for screening phylogenetic profiles in the absence of pre-formed protein families, we discovered that a homolog of the membrane protein EpsH (exopolysaccharide locus protein H occurs in a species when PEP-CTERM domains are found. The EpsH family contains invariant residues consistent with a transpeptidase function. Most PEP-CTERM proteins are encoded by single-gene operons preceded by large intergenic regions. In the Proteobacteria, most of these upstream regions share a DNA sequence, a probable cis-regulatory site that contains a sigma-54 binding motif. The phylogenetic profile for this DNA sequence exactly matches that of three proteins: a sigma-54-interacting response regulator (PrsR, a transmembrane histidine kinase (PrsK, and a TPR protein (PrsT. Conclusion These findings are consistent with the hypothesis

  9. Formulation development and rheological studies of palatable cefetamet pivoxil hydrochloride dry powder suspension

    Directory of Open Access Journals (Sweden)

    G Divakar

    2011-05-01

    Full Text Available Background and the purpose of the study: Because of its intense bitter taste and susceptibility to moisture Cefetamet Pivoxil (CPH is presently available only in the form of tablet. The aim of this study was to develop taste masked CPH dry powder suspension. Methods: Methods employed for formulations were: a Film coating of CPH using Eudragit E100 and subsequent adsorption on different carriers such as spray-dried lactose, sodium starch glycolate and spry-dried mannitol and b Complexation of CPH with three different ion exchange resins viz; indion 234, amberlite IRP64 and amberlite IRP69. Results: Taste evaluation as recognized by volunteers revealed that coating with eudragit E100 and subsequent adsorption on different carriers do not mask the bitter taste of the drug. Suspensions prepared using amberlite IRP64 and amberlite IRP69 were extremely palatable with no bitter after taste. They showed pseudoplastic flow behavior and were too viscous even after shearing for sufficient duration of time and exhibited poor pourability. The suspension made with indion 234 was palatable with slight or no bitter after taste. It demonstrated plastic flow with negligible thixotropy. It had moderate viscosity at rest and could be poured after a reasonable amount of shaking. CPH dry powder suspensions were very unstable under different conditions except under refrigeration. A 5% degradation of drug was occurred in reconstituted suspension in 4 days period when stored at room temperature. Conclusion: Dry powder suspension prepared with indion 234 with 5% overages was stable even after 4th day of reconstitution and palatable with slight or no bitter after taste

  10. Demand Side Management in a competitive European market: Who should be responsible for its implementation?

    International Nuclear Information System (INIS)

    Didden, Marcel H.; D'Haeseleer, William D.

    2003-01-01

    Demand side management (DSM), more specifically energy efficiency, is standing in the spotlight due to the Kyoto commitments. An additional factor, the liberalization of the electricity markets, causes every country to review its own DSM activities. Especially in Europe, where the directive for opening the electricity market has a direct impact on the current DSM frameworks, governments will have to consider a change in this framework. In order to achieve this, much research has been done in the past years on how to change the DSM framework in a way that the requirements of both liberalization and the Kyoto Protocol will be met. In this paper, we review the current DSM activities and ongoing research from the starting point 'who should be responsible for implementing DSM'. We conclude that countries have to make explicit choices on how to arrange their DSM activities for the different customers groups. They have to be aware of the fact that some combinations of DSM activities will lead to counter-productive results and therefore inefficiency. This paper also investigates which of these DSM activities fits best in the open market; a critical review of Integrated Resource Planning (IRP) is used as a starting point. We agree with various proponents of IRP that planning towards minimal societal costs is theoretically appropriate, looking from a societal point of view. We also indicate in this paper that the planning process IRP is partly applicable in the open market. But looking at the practical application of IRP in the past, we must conclude that there are better alternatives for achieving energy efficient goals in a liberalized market

  11. Solving Inventory Routing Problems Using Location Based Heuristics

    Directory of Open Access Journals (Sweden)

    Paweł Hanczar

    2014-01-01

    Full Text Available Inventory routing problems (IRPs occur where vendor managed inventory replenishment strategies are implemented in supply chains. These problems are characterized by the presence of both transportation and inventory considerations, either as parameters or constraints. The research presented in this paper aims at extending IRP formulation developed on the basis of location based heuristics proposed by Bramel and Simchi-Levi and continued by Hanczar. In the first phase of proposed algorithms, mixed integer programming is used to determine the partitioning of customers as well as dates and quantities of deliveries. Then, using 2-opt algorithm for solving the traveling sales-person problem the optimal routes for each partition are determined. In the main part of research the classical formulation is extended by additional constraints (visit spacing, vehicle filling rate, driver (vehicle consistency, and heterogeneous fleet of vehicles as well as the additional criteria are discussed. Then the impact of using each of proposed extensions for solution possibilities is evaluated. The results of computational tests are presented and discussed. Obtained results allow to conclude that the location based heuristics should be considered when solving real life instances of IRP. (original abstract

  12. Metabolomic profiling and sensorial quality of 'Golden Delicious', 'Liberty', 'Santana', and 'Topaz' apples grown using organic and integrated production systems.

    Science.gov (United States)

    Vanzo, Andreja; Jenko, Mojca; Vrhovsek, Urska; Stopar, Matej

    2013-07-03

    Apple quality was investigated in the scab-resistant 'Liberty', 'Santana', and 'Topaz' cultivars and the scab-susceptible 'Golden Delicious' cultivar. Trees subjected to the same crop load were cultivated using either an organic (ORG) or an integrated production (IP) system. Physicochemical properties, phenolic content, and sensorial quality of fruit from both systems were compared. There were no significant differences in fruit mass, starch, and total soluble solid content (the latter was higher in ORG 'Liberty') between ORG and IP fruit, whereas significantly higher flesh firmness was found in ORG fruit (except no difference in 'Golden Delicious'). Significantly higher total phenolic content in ORG fruit was found in 'Golden Delicious', whereas differences in other cultivars were not significant. Targeted metabolomic profiling of multiple classes of phenolics confirmed the impact of the production system on the 'Golden Delicious' phenolic profile as higher levels of 4-hydroxybenzoic acid, neo- and chlorogenic acids, phloridzin, procyanidin B2+B4, -3-O-glucoside and -3-O-galactoside of quercetin, kaempferol-3-O-rutinoside, and rutin being found in ORG fruit. The results obtained suggested that scab resistance influenced the phenolic biosynthesis in relation to the agricultural system. Sensorial evaluation indicated significantly better flavor (except for 'Topaz') and better appearance of IP fruit.

  13. Web User Profile Using XUL and Information Retrieval Techniques

    Directory of Open Access Journals (Sweden)

    Dan MUNTEANU

    2008-12-01

    Full Text Available This paper presents the importance of user profile in information retrieval, information filtering and recommender systems using explicit and implicit feedback. A Firefox extension (based on XUL used for gathering data needed to infer a web user profile and an example file with collected data are presented. Also an algorithm for creating and updating the user profile and keeping track of a fixed number k of subjects of interest is presented.

  14. Core fueling to produce peaked density profiles in large tokamaks

    International Nuclear Information System (INIS)

    Mikkelsen, D.R.; McGuire, K.M.; Schmidt, G.L.; Zweben, S.J.

    1994-06-01

    Peaking the density profile increases the usable bootstrap current and the average fusion power density; this could reduce the current drive power and increase the net output of power producing tokamaks. The use of neutral beams and pellet injection to produce peaked density profiles is assessed. We show that with radially ''hollow'' diffusivity profiles (and no particle pinch) moderately peaked density profiles can be produced by particle source profiles which are peaked off-axis. The fueling penetration requirements can therefore be relaxed and this greatly improves the feasibility of generating peaked density profiles in large tokamaks. In particular, neutral beam fueling does not require MeV particle energy. Even with beam voltages of ∼200 keV, however, exceptionally good particle confinement, τ p much-gt τ E is required to achieve net electrical power generation. In system with no power production requirement (e.g., neutron sources) neutral beam fueling should be capable of producing peaked density profiles in devices as large as ITER. Fueling systems with low energy cost per particle (such as cryogenic pellet injection) must be used in power producing tokamaks when τ p ∼ τ E . Simulations with pellet injection speeds of 7 km/sec show the peaking factor, n eo /left-angle n e right-angle, approaching 2

  15. Audiologist-patient communication profiles in hearing rehabilitation appointments.

    Science.gov (United States)

    Meyer, Carly; Barr, Caitlin; Khan, Asaduzzaman; Hickson, Louise

    2017-08-01

    To profile the communication between audiologists and patients in initial appointments on a biomedical-psychosocial continuum; and explore the associations between these profiles and 1) characteristics of the appointment and 2) patients' decisions to pursue hearing aids. Sixty-three initial hearing assessment appointments were filmed and audiologist-patient communication was coded using the Roter Interaction Analysis System. A hierarchical cluster analysis was conducted to profile audiologist-patient communication, after which regression modelling and Chi-squared analyses were conducted. Two distinct audiologist-patient communication profiles were identified during both the history taking phase (46=biopsychosocial profile, 15=psychosocial profile) and diagnosis and management planning phase (45=expanded biomedical profile, 11=narrowly biomedical profile). Longer appointments were significantly more likely to be associated with an expanded biomedical interaction during the diagnosis and management planning phase. No significant associations were found between audiologist-patient communication profile and patients' decisions to pursue hearing aids. Initial audiology consultations appear to remain clinician-centred. Three quarters of appointments began with a biopsychosocial interaction; however, 80% ended with an expanded biomedical interaction. Findings suggest that audiologists could consider modifying their communication in initial appointments to more holistically address the needs of patients. Copyright © 2017 Elsevier B.V. All rights reserved.

  16. Effect of the systemic versus inhalatory administration of synthetic glucocorticoids on the urinary steroid profile as studied by gas chromatography-mass spectrometry

    International Nuclear Information System (INIS)

    Mazzarino, Monica; Rossi, Francesca; Giacomelli, Laura; Botre, Francesco

    2006-01-01

    This paper presents a gas chromatography-mass spectrometry (GC-MS) study carried out on human urine to verify whether the administration of glucocorticoids can affect the urinary steroid profile, and especially the levels of endogenous glucocorticoids, androgens and their main metabolites. Betamethasone and beclomethasone, administered either systemically (per os or i.m.) or locally (by inhalation) have been studied. The determination of the urinary levels of endogenous glucocorticoids and androgens was carried out by GC-MS in electron impact ionization mode. Data were evaluated taking into account the baseline individual variability, and compared with values obtained on a control group. Detectable differences were recorded in the steroids metabolites excretion profiles between men and women. The circadian variability of the steroid profile was the same for both sexes, showing a maximum during the morning hours. After systemic treatment with synthetic glucocorticoids, the relative urinary concentrations of corticosteroids, androgens and of their metabolites were significantly altered, recording a transient decrease of the concentration of cortisol and tetrahydrocortisol and a parallel, although less pronounced, increase of the concentration of testosterone, epitestosterone and related androgenic steroids; while no effects were recorded if the administration was by inhalation

  17. Effect of the systemic versus inhalatory administration of synthetic glucocorticoids on the urinary steroid profile as studied by gas chromatography-mass spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Mazzarino, Monica [Laboratorio Antidoping, Federazione Medico Sportiva Italiana, Largo Giulio Onesti 1, 00197 Rome (Italy); Rossi, Francesca [Laboratorio Antidoping, Federazione Medico Sportiva Italiana, Largo Giulio Onesti 1, 00197 Rome (Italy); Giacomelli, Laura [Dipartimento di Scienze Chirurgiche, Universita La Sapienza, Viale Regina Elena 324, 00161 Rome (Italy); Botre, Francesco [Laboratorio Antidoping, Federazione Medico Sportiva Italiana, Largo Giulio Onesti 1, 00197 Rome (Italy) and Dipartimento CGMIA, Universita La Sapienza, Via del Castro Laurenziano 9, 00161 Rome (Italy)]. E-mail: francesco.botre@uniroma1.it

    2006-02-10

    This paper presents a gas chromatography-mass spectrometry (GC-MS) study carried out on human urine to verify whether the administration of glucocorticoids can affect the urinary steroid profile, and especially the levels of endogenous glucocorticoids, androgens and their main metabolites. Betamethasone and beclomethasone, administered either systemically (per os or i.m.) or locally (by inhalation) have been studied. The determination of the urinary levels of endogenous glucocorticoids and androgens was carried out by GC-MS in electron impact ionization mode. Data were evaluated taking into account the baseline individual variability, and compared with values obtained on a control group. Detectable differences were recorded in the steroids metabolites excretion profiles between men and women. The circadian variability of the steroid profile was the same for both sexes, showing a maximum during the morning hours. After systemic treatment with synthetic glucocorticoids, the relative urinary concentrations of corticosteroids, androgens and of their metabolites were significantly altered, recording a transient decrease of the concentration of cortisol and tetrahydrocortisol and a parallel, although less pronounced, increase of the concentration of testosterone, epitestosterone and related androgenic steroids; while no effects were recorded if the administration was by inhalation.

  18. World Energy Data System (WENDS). Volume VII. Nuclear facility profiles, AG--CH. [Brief tabulated information

    Energy Technology Data Exchange (ETDEWEB)

    1979-06-01

    In this compendium each profile of a nuclear facility is a capsule summary of pertinent facts regarding that particular installation. The facilities described include the entire fuel cycle in the broadest sense, encompassing resource recovery through waste management. Power plants and all US facilities have been excluded. To facilitate comparison the profiles have been recorded in a standard format. Because of the breadth of the undertaking some data fields do not apply to the establishment under discussion and accordingly are blank. The set of nuclear facility profiles occupies four volumes; the profiles are ordered by country name, and then by facility code. Each nuclear facility profile volume contains two complete indexes to the information. The first index aggregates the facilities alphabetically by country. It is further organized by category of facility, and then by the four-character facility code. It provides a quick summary of the nuclear energy capability or interest in each country and also an identifier, the facility code, which can be used to access the information contained in the profile.

  19. World Energy Data System (WENDS). Volume VIII. Nuclear facility profiles, CO--HU. [Brief tabulated information

    Energy Technology Data Exchange (ETDEWEB)

    1979-06-01

    In this compendium each profile of a nuclear facility is a capsule summary of pertinent facts regarding that particular installation. The facilities described include the entire fuel cycle in the broadest sense, encompassing resource recovery through waste management. Power plants and all US facilities have been excluded. To facilitate comparison the profiles have been recorded in a standard format. Because of the breadth of the undertaking some data fields do not apply to the establishment under discussion and accordingly are blank. The set of nuclear facility profiles occupies four volumes; the profiles are ordered by country name, and then by facility code. Each nuclear facility profile volume contains two complete indexes to the information. The first index aggregates the facilities alphabetically by country. It is further organized by category of facility, and then by the four-character facility code. It provides a quick summary of the nuclear energy capability or interest in each country and also an identifier, the facility code, which can be used to access the information contained in the profile.

  20. World Energy Data System (WENDS). Volume IX. Nuclear facility profiles, IN--PL. [Brief tabulated information

    Energy Technology Data Exchange (ETDEWEB)

    1979-06-01

    In this compendium each profile of a nuclear facility is a capsule summary of pertinent facts regarding that particular installation. The facilities described include the entire fuel cycle in the broadest sense, encompassing resource recovery through waste management. Power plants and all US facilities have been excluded. To facilitate comparison the profiles have been recorded in a standard format. Because of the breadth of the undertaking some data fields do not apply to the establishment under discussion and accordingly are blank. The set of nuclear facility profiles occupies four volumes; the profiles are ordered by country name, and then by facility code. Each nuclear facility profile volume contains two complete indexes to the information. The first index aggregates the facilities alphabetically by country. It is further organized by category of facility, and then by the four-character facility code. It provides a quick summary of the nuclear energy capability or interest in each country and also an identifier, the facility code, which can be used to access the information contained in the profile.

  1. World Energy Data System (WENDS). Volume X. Nuclear facility profiles, PO--ZA. [Brief tabulated information

    Energy Technology Data Exchange (ETDEWEB)

    1979-06-01

    In this compendium each profile of a nuclear facility is a capsule summary of pertinent facts regarding that particular installation. The facilities described include the entire fuel cycle in the broadest sense, encompassing resource recovery through waste management. Power plants and all US facilities have been excluded. To facilitate comparison the profiles have been recorded in a standard format. Because of the breadth of the undertaking some data fields do not apply to the establishment under discussion and accordingly are blank. The set of nuclear facility profiles occupies four volumes; the profiles are ordered by country name, and then by facility code. Each nuclear facility profile volume contains two complete indexes to the information. The first index aggregates the facilities alphabetically by country. It is further organized by category of facility, and then by the four-character facility code. It provides a quick summary of the nuclear energy capability or interest in each country and also an identifier, the facility code, which can be used to access the information contained in the profile.

  2. Considering inventory distributions in a stochastic periodic inventory routing system

    Science.gov (United States)

    Yadollahi, Ehsan; Aghezzaf, El-Houssaine

    2017-07-01

    Dealing with the stochasticity of parameters is one of the critical issues in business and industry nowadays. Supply chain planners have difficulties in forecasting stochastic parameters of a distribution system. Demand rates of customers during their lead time are one of these parameters. In addition, holding a huge level of inventory at the retailers is costly and inefficient. To cover the uncertainty of forecasting demand rates, researchers have proposed the usage of safety stock to avoid stock-out. However, finding the precise level of safety stock depends on forecasting the statistical distribution of demand rates and their variations in different settings among the planning horizon. In this paper the demand rate distributions and its parameters are taken into account for each time period in a stochastic periodic IRP. An analysis of the achieved statistical distribution of the inventory and safety stock level is provided to measure the effects of input parameters on the output indicators. Different values for coefficient of variation are applied to the customers' demand rate in the optimization model. The outcome of the deterministic equivalent model of SPIRP is simulated in form of an illustrative case.

  3. Metabolic Profiles of Brain Metastases

    Directory of Open Access Journals (Sweden)

    Tone F. Bathen

    2013-01-01

    Full Text Available Metastasis to the brain is a feared complication of systemic cancer, associated with significant morbidity and poor prognosis. A better understanding of the tumor metabolism might help us meet the challenges in controlling brain metastases. The study aims to characterize the metabolic profile of brain metastases of different origin using high resolution magic angle spinning (HR-MAS magnetic resonance spectroscopy (MRS to correlate the metabolic profiles to clinical and pathological information. Biopsy samples of human brain metastases (n = 49 were investigated. A significant correlation between lipid signals and necrosis in brain metastases was observed (p < 0.01, irrespective of their primary origin. The principal component analysis (PCA showed that brain metastases from malignant melanomas cluster together, while lung carcinomas were metabolically heterogeneous and overlap with other subtypes. Metastatic melanomas have higher amounts of glycerophosphocholine than other brain metastases. A significant correlation between microscopically visible lipid droplets estimated by Nile Red staining and MR visible lipid signals was observed in metastatic lung carcinomas (p = 0.01, indicating that the proton MR visible lipid signals arise from cytoplasmic lipid droplets. MRS-based metabolomic profiling is a useful tool for exploring the metabolic profiles of metastatic brain tumors.

  4. Expected Performance of Ozone Climate Data Records from Ozone Mapping and Profiler Suite Limb Profiler

    Science.gov (United States)

    Xu, P. Q.; Rault, D. F.; Pawson, S.; Wargan, K.; Bhartia, P. K.

    2012-01-01

    The Ozone Mapping and Profiler Suite Limb Profiler (OMPS/LP) was launched on board of the Soumi NPP space platform in late October 2011. It provides ozone-profiling capability with high-vertical resolution from 60 Ian to cloud top. In this study, an end-to-end Observing System Simulation Experiment (OSSE) of OMPS/LP ozone is discussed. The OSSE was developed at NASA's Global Modeling and Assimilation Office (GMAO) using the Goddard Earth Observing System (GEOS-5) data assimilation system. The "truth" for this OSSE is built by assimilating MLS profiles and OMI ozone columns, which is known to produce realistic three-dimensional ozone fields in the stratosphere and upper troposphere. OMPS/LP radiances were computed at tangent points computed by an appropriate orbital model. The OMPS/LP forward RT model, Instrument Models (IMs) and EDR retrieval model were introduced and pseudo-observations derived. The resultant synthetic OMPS/LP observations were evaluated against the "truth" and subsequently these observations were assimilated into GEOS-5. Comparison of this assimilated dataset with the "truth" enables comparisons of the likely uncertainties in 3-D analyses of OMPS/LP data. This study demonstrated the assimilation capabilities of OMPS/LP ozone in GEOS-5, with the monthly, zonal mean (O-A) smaller than 0.02ppmv at all levels, the nns(O-A) close to O.lppmv from 100hPa to 0.2hPa; and the mean(O-B) around the 0.02ppmv for all levels. The monthly zonal mean analysis generally agrees to within 2% of the truth, with larger differences of 2-4% (0.1-0.2ppmv) around 10hPa close to North Pole and in the tropical tropopause region, where the difference is above 20% due to the very low ozone concentrations. These OSSEs demonstrated that, within a single data assimilation system and the assumption that assimilated MLS observations provide a true rendition of the stratosphere, the OMPS/LP ozone data are likely to produce accurate analyses through much of the stratosphere

  5. Sensory profiles of breast meat from broilers reared in an organic niche production system and conventional standard broilers

    DEFF Research Database (Denmark)

    Horsted, Klaus; Allesen-Holm, Bodil Helene; Hermansen, John E.

    2012-01-01

    BACKGROUND: Breast meat from broilers produced in very different production systems may vary considerable in sensory profile, which may affect consumer interests. In this study the aim was to evaluate differences in the sensory profiles of breast meat from five broiler products: two conventional...... standard products (A and B) and three organic niche genotypes (I657, L40 and K8) reared in an apple orchard. RESULTS: Thirteen out of 22 sensory attributes differed significantly between the products. The aroma attributes `chicken', `bouillon' and `fat' scored highest and the `iron/liver' aroma lowest...... of `sweet/maize' than the standard products. The `overall liking' score was significantly higher for the `K 8' product than for the `Standard A' and `L 40' products. The `overall liking' score was significantly correlated with the scores for aroma and taste of `chicken', `umami/bouillon', `iron...

  6. Solar line Lsub(α) profile and an interstellar wind dynamics

    International Nuclear Information System (INIS)

    Burgin, M.S.

    1978-01-01

    Analytical theory of interstellar hydrogen atom motion into the region of solar Lsub(α)-radiation is given. Hydrogen distribution in the Solar system is calculated with an account of the Lsub(α) solar line profile difference from a flat one. The effect of the profile form on the scattered radiation intensity is estimated. Calculation errors of the scattered radiation intensity, connected with the difference between a line profile and a flat one, do not exceed 5% for the real Lsub(α) solar line profile

  7. Heat demand profiles of energy conservation measures in buildings and their impact on a district heating system

    International Nuclear Information System (INIS)

    Lundström, Lukas; Wallin, Fredrik

    2016-01-01

    Highlights: • Energy savings impact on an low CO 2 emitting district heating system. • Heat profiles of eight building energy conservation measures. • Exhaust air heat pump, heat recovery ventilation, electricity savings etc. • Heat load weather normalisation with segmented multivariable linear regression. - Abstract: This study highlights the forthcoming problem with diminishing environmental benefits from heat demand reducing energy conservation measures (ECM) of buildings within district heating systems (DHS), as the supply side is becoming “greener” and more primary energy efficient. In this study heat demand profiles and annual electricity-to-heat factors of ECMs in buildings are computed and their impact on system efficiency and greenhouse gas emissions of a Swedish biomass fuelled and combined heat and power utilising DHS are assessed. A weather normalising method for the DHS heat load is developed, combining segmented multivariable linear regressions with typical meteorological year weather data to enable the DHS model and the buildings model to work under the same weather conditions. Improving the buildings’ envelope insulation level and thereby levelling out the DHS heat load curve reduces greenhouse gas emissions and improves primary energy efficiency. Reducing household electricity use proves to be highly beneficial, partly because it increases heat demand, allowing for more cogeneration of electricity. However the other ECMs considered may cause increased greenhouse gas emissions, mainly because of their adverse impact on the cogeneration of electricity. If biomass fuels are considered as residuals, and thus assigned low primary energy factors, primary energy efficiency decreases when implementing ECMs that lower heat demand.

  8. Profile measurement of a bent neutron mirror using an ultrahigh precision non-contact measurement system with an auto focus laser probe

    International Nuclear Information System (INIS)

    Morita, S; Guo, J; Yamagata, Y; Yamada, N L; Torikai, N; Takeda, S; Furusaka, M

    2016-01-01

    A bent neutron mirror has been considered as one of the best solutions for focusing neutron beams from the viewpoint of cost-benefit performance. Although the form deviation of the bent profile is expected because of the large spot size, it is difficult to measure due to its geometric limitation. Here, we propose a non-contact measurement system using an auto focus (AF) laser probe on an ultrahigh precision machine tool to precisely evaluate the form deviation of the bent mirror. The AF laser probe is composed of a diode laser, a position sensitive sensor, a charge-coupled device (CCD) camera and a microscope objective lens which is actuated by an electromagnetic motor with 1 nm resolution for position sensing and control. The sensor enables a non-contact profile measurement of a high precision surface without any surface damage in contrast with contact-type ultrahigh precision coordinate measurement machines with ruby styli. In the on-machine measurement system, a personal computer simultaneously acquires a displacement signal from the AF laser probe and 3-axis positional coordinates of the ultrahigh machine tool branched between the linear laser scales and the numerical controller. The acquisition rate of the 4-axis positional data in 1 nm resolution is more than 10 Hz and the simultaneity between the axes is negligible. The profile of a neutron bent mirror was measured from a transparent side using the developed system, and the result proves that the form deviation of the mirror enlarged the the spot size of focused neuron beam. (paper)

  9. Mechanical energy profiles of the combined ankle-foot system in normal gait: insights for prosthetic designs.

    Science.gov (United States)

    Takahashi, Kota Z; Stanhope, Steven J

    2013-09-01

    Over the last half-century, the field of prosthetic engineering has continuously evolved with much attention being dedicated to restoring the mechanical energy properties of ankle joint musculatures during gait. However, the contributions of 'distal foot structures' (e.g., foot muscles, plantar soft tissue) have been overlooked. Therefore, the purpose of this study was to quantify the total mechanical energy profiles (e.g., power, work, and work-ratio) of the natural ankle-foot system (NAFS) by combining the contributions of the ankle joint and all distal foot structures during stance in level-ground steady state walking across various speeds (0.4, 0.6, 0.8 and 1.0 statures/s). The results from eleven healthy subjects walking barefoot indicated ankle joint and distal foot structures generally performed opposing roles: the ankle joint performed net positive work that systematically increased its energy generation with faster walking speeds, while the distal foot performed net negative work that systematically increased its energy absorption with faster walking speeds. Accounting for these simultaneous effects, the combined ankle-foot system exhibited increased work-ratios with faster walking. Most notably, the work-ratio was not significantly greater than 1.0 during the normal walking speed of 0.8 statures/s. Therefore, a prosthetic design that strategically exploits passive-dynamic properties (e.g., elastic energy storage and return) has the potential to replicate the mechanical energy profiles of the NAFS during level-ground steady-state walking. Copyright © 2013 Elsevier B.V. All rights reserved.

  10. Nonparametric estimates of drift and diffusion profiles via Fokker-Planck algebra.

    Science.gov (United States)

    Lund, Steven P; Hubbard, Joseph B; Halter, Michael

    2014-11-06

    Diffusion processes superimposed upon deterministic motion play a key role in understanding and controlling the transport of matter, energy, momentum, and even information in physics, chemistry, material science, biology, and communications technology. Given functions defining these random and deterministic components, the Fokker-Planck (FP) equation is often used to model these diffusive systems. Many methods exist for estimating the drift and diffusion profiles from one or more identifiable diffusive trajectories; however, when many identical entities diffuse simultaneously, it may not be possible to identify individual trajectories. Here we present a method capable of simultaneously providing nonparametric estimates for both drift and diffusion profiles from evolving density profiles, requiring only the validity of Langevin/FP dynamics. This algebraic FP manipulation provides a flexible and robust framework for estimating stationary drift and diffusion coefficient profiles, is not based on fluctuation theory or solved diffusion equations, and may facilitate predictions for many experimental systems. We illustrate this approach on experimental data obtained from a model lipid bilayer system exhibiting free diffusion and electric field induced drift. The wide range over which this approach provides accurate estimates for drift and diffusion profiles is demonstrated through simulation.

  11. Electron number density profiles derived from radio occultation on the CASSIOPE spacecraft

    DEFF Research Database (Denmark)

    Shume, E. B.; Vergados, P.; Komjathy, A.

    2017-01-01

    This paper presents electron number density profiles derived from high resolution Global Positioning System (GPS) radio occultation (RO) observations performed using the Enhanced Polar Outflow Probe (e-POP) payload on the high inclination CAScade, Smallsat and IOnospheric Polar Explorer (CASSIOPE...... good agreement with density profiles estimated from ionosonde data, measured over nearby stations to the latitude and longitude of the RO tangent points, (2) in good agreement with density profiles inferred from GPS RO measured by the Constellation Observing System for Meteorology, Ionosphere...

  12. Data Profiling

    OpenAIRE

    Hladíková, Radka

    2010-01-01

    Title: Data Profiling Author: Radka Hladíková Department: Department of Software Engineering Supervisor: Ing. Vladimír Kyjonka Supervisor's e-mail address: Abstract: This thesis puts mind on problems with data quality and data profiling. This Work analyses and summarizes problems of data quality, data defects, process of data quality, data quality assessment and data profiling. The main topic is data profiling as a process of researching data available in existing...

  13. On the relation between plasma and neutral gas profiles in a cold gas-blanket system

    International Nuclear Information System (INIS)

    Bures, M.

    1981-01-01

    A solution for the neutral density profile using the measured plasma density and temperature gradients is presented. The fluid model is used. It is found that the penetration length for neutrals is underestimated in the situation where the integrated profiles are used. The ionization rate need not be inferred in the present calculation, because the ionization of neutrals diffusing into the plasma is implicitly included in measured profiles. This calculation is advantageous in the low temperature range where the ionization rate is a strongly varying function of temperature. Finally the presented solution indicates that the temperature gradient plays the essential role in the determination of the neutral density profile. (Auth.)

  14. Measurement of slice sensitivity profile for a 64-slice spiral CT system

    International Nuclear Information System (INIS)

    Liu Chuanya; Qin Weichang; Wang Wei; Lu Chuanyou

    2006-01-01

    Objective: To measure and evaluate slice sensitivity profile (SSP) and the full width at half-maximum(FWHM) for a 64-slice spiral CT system. Methods: Using the same CT technique and body mode as those used for clinical CT, delta phantom was scanned with Somatom Sensation 64-slice spiral CT. SSPs and FWHM were measured both with reconstruction slice width of 0.6 mm at pitch=0.50, 0.75, 1.00, 1.25, 1.50 and with reconstruction slice width of 0.6, 1.0, 1.5 mm at pitch=1 respectively. Results: For normal slice width of 0. 6 mm, the measured FWHM, i.e. effective slice width, is 0.67, 0.67, 0.66, 0.69, 0.69 mm at different pitch. All the measured FWHM deviate less than 0.1 mm from the nominal slice width. The measured SSPs are symmetrical, bell-shaped curves without far-reaching tails, and show only slight variations as a function of the spiral pitch. When reconstruction slice width increase, relative SSP become wider. Conclusions: The variation of pitch hardly has effect all on SSP, effective slice width, and z-direction spatial resolution for Sensation 64-slice spiral CT system, which is helpful to optimize CT scanning protocol. (authors)

  15. Core fuelling to produce peaked density profiles in large tokamaks

    International Nuclear Information System (INIS)

    Mikkelsen, D.R.; McGuire, K.M.; Schmidt, G.L.; Zweben, S.J.

    1995-01-01

    Peaking the density profile increases the usable bootstrap current and the average fusion power density; this could reduce the current drive power and increase the net output of power producing tokamaks. The use of neutral beams and pellet injection to produce peaked density profiles is assessed. It is shown that with radially 'hollow' diffusivity profiles (and no particle pinch) moderately peaked density profiles can be produced by particle source profiles that are peaked off-axis. The fuelling penetration requirements can therefore be relaxed and this greatly improves the feasibility of generating peaked density profiles in large tokamaks. In particular, neutral beam fuelling does not require Megavolt particle energies. Even with beam voltages of ∼ 200 keV, however, exceptionally good particle confinement is needed to achieve net electrical power generation. The required ratio of particle to thermal diffusivities is an order of magnitude outside the range reported for tokamaks. In a system with no power production requirement (e.g., neutron sources) neutral beam fuelling should be capable of producing peaked density profiles in devices as large as ITER. Fuelling systems with low energy cost per particle - such as cryogenic pellet injection - must be used in power producing tokamaks when τ P ∼ τ E . Simulations with pellet injection speeds of 7 km/s show that the peaking factor, n e0 / e >, approaches 2. (author). 65 refs, 8 figs

  16. Changes in the aromatic profile of espresso coffee as a function of the grinding grade and extraction time: a study by the electronic nose system.

    Science.gov (United States)

    Severini, C; Ricci, I; Marone, M; Derossi, A; De Pilli, T

    2015-03-04

    The changes in chemical attributes and aromatic profile of espresso coffee (EC) were studied taking into account the extraction time and grinding level as independent variables. Particularly, using an electronic nose system, the changes of the global aromatic profile of EC were highlighted. The results shown as the major amounts of organic acids, solids, and caffeine were extracted in the first 8 s of percolation. The grinding grade significantly affected the quality of EC probably as an effect of the particle size distribution and the percolation pathways of water through the coffee cake. The use of an electronic nose system allowed us to discriminate the fractions of the brew as a function of the percolation time and also the regular coffee obtained from different grinding grades. Particularly, the aromatic profile of a regular coffee (25 mL) was significantly affected by the grinding level of the coffee grounds and percolation time, which are two variables under the control of the bar operator.

  17. [Effects of peroral endoscopic myotomy on esophageal dynamics in patients with esophageal achalasia].

    Science.gov (United States)

    Zhong, Yun-shi; Li, Liang; Zhou, Ping-hong; Xu, Mei-dong; Ren, Zhong; Zhu, Bo-qun; Yao, Li-qing

    2012-07-01

    To investigate the effects of peroral endoscopic myotomy(POEM) on esophageal dynamics in patients with esophageal achalasia. From September 2011 to November 2011, 20 cases with esophageal achalasia received POEM at the Endoscopic Center in the Zhongshan Hospital of Fudan University. Pre-operation esophageal dynamics of all the patients were evaluated by high resolution manometry(HRM) system and 3 days after operation the test was repeated. Lower esophagus sphincter resting pressure(LESP), 4-second integrated relaxation pressure(4sIRP), lower esophagus sphincter relax rate(LESRR), lower esophagus sphincter length(LESL), and esophageal manometry were analyzed. After POEM, LESP decreased from(29.1±17.0) mm Hg to(14.6±4.9) mm Hg, and decrease rate was 49.8%(P0.05). Esophageal peristaltic contraction was absent in all the 20 patients preoperatively. After POEM, changes in the esophageal contraction were seen in 7 patients, and peristalsis was noticed but was below normal level. There were no significant changes in peristalsis in the remaining 13 patients. POEM can significantly reduce LESP and 4sIRP in patients with achalasia, but can not affect the contraction of the esophagus.

  18. Behavioural Profiling in Cyber-Social Systems

    DEFF Research Database (Denmark)

    Perno, Jason; Probst, Christian W.

    2017-01-01

    Computer systems have evolved from standalone systems, over networked systems, to cyber-physical systems. In all stages, human operators have been essential for the functioning of the system and for understanding system messages. Recent trends make human actors an even more central part of computer...... systems, resulting in what we call "cyber-social systems". In cyber-social systems, human actors and their interaction with a system are essential for the state of the system and its functioning. Both the system's operation and the human's operating it are based on an assumption of each other's behaviour...

  19. Application of the British Food Standards Agency nutrient profiling system in a French food composition database.

    Science.gov (United States)

    Julia, Chantal; Kesse-Guyot, Emmanuelle; Touvier, Mathilde; Méjean, Caroline; Fezeu, Léopold; Hercberg, Serge

    2014-11-28

    Nutrient profiling systems are powerful tools for public health initiatives, as they aim at categorising foods according to their nutritional quality. The British Food Standards Agency (FSA) nutrient profiling system (FSA score) has been validated in a British food database, but the application of the model in other contexts has not yet been evaluated. The objective of the present study was to assess the application of the British FSA score in a French food composition database. Foods from the French NutriNet-Santé study food composition table were categorised according to their FSA score using the Office of Communication (OfCom) cut-off value ('healthier' ≤ 4 for foods and ≤ 1 for beverages; 'less healthy' >4 for foods and >1 for beverages) and distribution cut-offs (quintiles for foods, quartiles for beverages). Foods were also categorised according to the food groups used for the French Programme National Nutrition Santé (PNNS) recommendations. Foods were weighted according to their relative consumption in a sample drawn from the NutriNet-Santé study (n 4225), representative of the French population. Classification of foods according to the OfCom cut-offs was consistent with food groups described in the PNNS: 97·8 % of fruit and vegetables, 90·4 % of cereals and potatoes and only 3·8 % of sugary snacks were considered as 'healthier'. Moreover, variability in the FSA score allowed for a discrimination between subcategories in the same food group, confirming the possibility of using the FSA score as a multiple category system, for example as a basis for front-of-pack nutrition labelling. Application of the FSA score in the French context would adequately complement current public health recommendations.

  20. Relationship of carbohydrates and lignin molecular structure spectral profiles to nutrient profile in newly developed oats cultivars and barley grain

    Science.gov (United States)

    Prates, Luciana Louzada; Refat, Basim; Lei, Yaogeng; Louzada-Prates, Mariana; Yu, Peiqiang

    2018-01-01

    The objectives of this study were to quantify the chemical profile and the magnitude of differences in the oat and barley grain varieties developed by Crop Development Centre (CDC) in terms of Cornell Net Carbohydrate Protein System (CNCPS) carbohydrate sub-fractions: CA4 (sugars), CB1 (starch), CB2 (soluble fibre), CB3 (available neutral detergent fibre - NDF), and CC (unavailable carbohydrate); to estimate the energy values; to detect the lignin and carbohydrate (CHO) molecular structure profiles in CDC Nasser and CDC Seabiscuit oat and CDC Meredith barley grains by using Fourier transform infrared attenuated total reflectance (FTIR-ATR); to develop a model to predict nutrient supply based on CHO molecular profile. Results showed that NDF, ADF and CHO were greater (P 0.05) for oat and barley grains as well as non-structural CHO. However, cellulosic compounds peak area and height were greater (P < 0.05) in oat than barley grains. Multiple regressions were determined to predict nutrient supply by using lignin and CHO molecular profiles. It was concluded that although there were some differences between oat and barley grains, CDC Nasser and CDC Meredith presented similarities related to chemical and molecular profiles, indicating that CDC Meredith barley could be replaced for CDC Nasser as ruminant feed. The FTIR was able to identify functional groups related to CHO molecular spectral in oat and barley grains and FTIR-ATR results could be used to predict nutrient supply in ruminant livestock systems.

  1. A high resolution, single bunch, beam profile monitor

    International Nuclear Information System (INIS)

    Norem, J.

    1992-01-01

    We developed a beam monitoring system which could be used to measure beam profile, size and stability at the final forms of a beamline or collider. The system uses nonimaging bremsstrahlung optics. The immediate use for this system would be examining the final focus spot at the SLAC/FFTR

  2. Quality Control Algorithms and Proposed Integration Process for Wind Profilers Used by Launch Vehicle Systems

    Science.gov (United States)

    Decker, Ryan; Barbre, Robert E., Jr.

    2011-01-01

    Impact of winds to space launch vehicle include Design, Certification Day-of-launch (DOL) steering commands (1)Develop "knockdowns" of load indicators (2) Temporal uncertainty of flight winds. Currently use databases from weather balloons. Includes discrete profiles and profile pair datasets. Issues are : (1)Larger vehicles operate near design limits during ascent 150 discrete profiles per month 110-217 seasonal 2.0 and 3.5-hour pairs Balloon rise time (one hour) and drift (up to 100 n mi) Advantages of the Alternative approach using Doppler Radar Wind Profiler (DRWP) are: (1) Obtain larger sample size (2) Provide flexibility for assessing trajectory changes due to winds (3) Better representation of flight winds.

  3. The Effect of Electric Load Profiles on the Performance of Off-Grid Residential Hybrid Renewable Energy Systems

    Directory of Open Access Journals (Sweden)

    Stephen Treado

    2015-10-01

    Full Text Available This paper investigates the energy performance of off-grid residential hybrid renewable electric power systems, particularly the effect of electric load profiles on the ability to harvest available solar energy and avoid the consumption of auxiliary energy in the form of propane. The concepts are illustrated by an analysis of the energy performance of electric and propane-fired refrigerators. Off-grid electric power systems frequently incorporate a renewable source, such as wind or solar photovoltaic (PV, with a back-up power provided by a propane fueled motor/generator. Among other design decisions, residential consumers face the choice of employing an electric refrigerator with a conventional vapor compression refrigeration system, or a fuel-fired refrigerator operating as an absorption refrigeration system. One interesting question is whether it is more advantageous from an energy perspective to use electricity to run the refrigerator, which might be provided by some combination of the PV and propane motor/generator, thereby taking advantage of the relatively higher electric refrigerator Coefficient of Performance (COP and free solar energy but having to accept a low electrical conversion efficiency of the motor/generator, or use thermal energy from the combustion of propane to produce the refrigeration effect via an absorption system, albeit with a much lower COP. The analysis is complicated by the fact that most off-grid renewable electrical power systems utilize a battery bank to provide electrical power when it is not available from the wind turbine or PV system, so the state of charge of the battery bank will have a noticeable impact on what energy source is available at any moment in time. Daily electric load profiles combined with variable solar energy input determine the state of charge of the battery bank, with the degree of synchronization between the two being a critical factor in determining performance. The annual energy usage

  4. Impact of profile observations on the German Weather Service's NWP system

    Directory of Open Access Journals (Sweden)

    Alexander Cress

    2001-04-01

    Full Text Available In preparation for a study on the potential impact of a space-borne Doppler wind lidar on the quality of NWP products, a series of assimilations and forecasts were conducted to estimate the potential benefit of conventional wind and temperature profile measurements over North America to numerical weather forecasts for the Northern Hemisphere and specifically, Europe. A comparison of the forecast quality of a control run, using all available observations, to experiments omitting wind and temperature data from specific instruments (radiosondes, pilot stations and aircraft makes it possible to estimate the importance of the omitted data, and clarify whether winds derived from the geostrophic relation are sufficient or whether observed wind profiles result in a more realistic definition of the initial state for numerical weather prediction systems in the extra-tropic regions. Very little impact on forecast quality was noted when wind or temperature observations from radiosondes and pilots were excluded from the assimilation process. However, a clear deterioration in forecast quality was observed when additionally all available wind or temperature measurements from aircraft were also withheld. Comparisons of the relative utility of wind and temperature observations over North America show that assimilations and forecasts derive more benefit from wind data than from temperature data. The greatest deterioration could be observed if both wind and temperature observations were omitted from the assimilation cycle. By tracing the differences between the control forecasts and the experimental forecasts to their initial difference, the regions around Hudson Bay, Novia Scotia, Buffin Bay and Northern Canada could be identified as sensitive areas, i.e. those where a missing observation could have a substantial effect on the forecast for the Northern Hemisphere and Europe. Comparisons of the relative utility of radiosonde wind and temperature observations over

  5. Long-term aerobic exercise increases redox-active iron through nitric oxide in rat hippocampus.

    Science.gov (United States)

    Chen, Qian; Xiao, De-Sheng

    2014-01-30

    Adult hippocampus is highly vulnerable to iron-induced oxidative stress. Aerobic exercise has been proposed to reduce oxidative stress but the findings in the hippocampus are conflicting. This study aimed to observe the changes of redox-active iron and concomitant regulation of cellular iron homeostasis in the hippocampus by aerobic exercise, and possible regulatory effect of nitric oxide (NO). A randomized controlled study was designed in the rats with swimming exercise treatment (for 3 months) and/or an unselective inhibitor of NO synthase (NOS) (L-NAME) treatment. The results from the bleomycin-detectable iron assay showed additional redox-active iron in the hippocampus by exercise treatment. The results from nonheme iron content assay, combined with the redox-active iron content, showed increased storage iron content by exercise treatment. NOx (nitrate plus nitrite) assay showed increased NOx content by exercise treatment. The results from the Western blot assay showed decreased ferroportin expression, no changes of TfR1 and DMT1 expressions, increased IRP1 and IRP2 expression, increased expressions of eNOS and nNOS rather than iNOS. In these effects of exercise treatment, the increased redox-active iron content, storage iron content, IRP1 and IRP2 expressions were completely reversed by L-NAME treatment, and decreased ferroportin expression was in part reversed by L-NAME. L-NAME treatment completely inhibited increased NOx and both eNOS and nNOS expression in the hippocampus. Our findings suggest that aerobic exercise could increase the redox-active iron in the hippocampus, indicating an increase in the capacity to generate hydroxyl radicals through the Fenton reactions, and aerobic exercise-induced iron accumulation in the hippocampus might mainly result from the role of the endogenous NO. Copyright © 2013 Elsevier Inc. All rights reserved.

  6. Load Forecasting in Electric Utility Integrated Resource Planning

    Energy Technology Data Exchange (ETDEWEB)

    Carvallo, Juan Pablo [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Larsen, Peter H. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Sanstad, Alan H [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Goldman, Charles A. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2017-07-19

    Integrated resource planning (IRP) is a process used by many vertically-integrated U.S. electric utilities to determine least-cost/risk supply and demand-side resources that meet government policy objectives and future obligations to customers and, in many cases, shareholders. Forecasts of energy and peak demand are a critical component of the IRP process. There have been few, if any, quantitative studies of IRP long-run (planning horizons of two decades) load forecast performance and its relationship to resource planning and actual procurement decisions. In this paper, we evaluate load forecasting methods, assumptions, and outcomes for 12 Western U.S. utilities by examining and comparing plans filed in the early 2000s against recent plans, up to year 2014. We find a convergence in the methods and data sources used. We also find that forecasts in more recent IRPs generally took account of new information, but that there continued to be a systematic over-estimation of load growth rates during the period studied. We compare planned and procured resource expansion against customer load and year-to-year load growth rates, but do not find a direct relationship. Load sensitivities performed in resource plans do not appear to be related to later procurement strategies even in the presence of large forecast errors. These findings suggest that resource procurement decisions may be driven by other factors than customer load growth. Our results have important implications for the integrated resource planning process, namely that load forecast accuracy may not be as important for resource procurement as is generally believed, that load forecast sensitivities could be used to improve the procurement process, and that management of load uncertainty should be prioritized over more complex forecasting techniques.

  7. Error Correction of Measured Unstructured Road Profiles Based on Accelerometer and Gyroscope Data

    Directory of Open Access Journals (Sweden)

    Jinhua Han

    2017-01-01

    Full Text Available This paper describes a noncontact acquisition system composed of several time synchronized laser height sensors, accelerometers, gyroscope, and so forth in order to collect the road profiles of vehicle riding on the unstructured roads. A method of correcting road profiles based on the accelerometer and gyroscope data is proposed to eliminate the adverse impacts of vehicle vibration and attitudes change. Because the power spectral density (PSD of gyro attitudes concentrates in the low frequency band, a method called frequency division is presented to divide the road profiles into two parts: high frequency part and low frequency part. The vibration error of road profiles is corrected by displacement data obtained through two times integration of measured acceleration data. After building the mathematical model between gyro attitudes and road profiles, the gyro attitudes signals are separated from low frequency road profile by the method of sliding block overlap based on correlation analysis. The accuracy and limitations of the system have been analyzed, and its validity has been verified by implementing the system on wheeled equipment for road profiles’ measuring of vehicle testing ground. The paper offers an accurate and practical approach to obtaining unstructured road profiles for road simulation test.

  8. Compression and heating of a cladding target by a partially profiled laser pulse

    International Nuclear Information System (INIS)

    Andreev, A.A.; Samsonov, A.G.; Solov'ev, N.A.

    1990-01-01

    The CLADDING-T semiempirical model and numerical calculations in accordance with the SPHERE program have been employed to show that the action of a partially profiled pulse on a simple cladding target raises the fuel compession degree and reduces the fuel temperature as compared to the action of a rectangular pulse (or a polynomial-shaped pulse) with the same energy. From the standpoint of the flash criterion the system composed of the profiled pulse and the simple (cladding) target is shown to be equivalent to that composed of a simple pulse and a dual-cascade (profiled) target. An analysis of the system composed of the laser and the simple target shows that the use of the partially profiled pulse and the simple target makes it possible to reduce requirements to the energy of laser systems

  9. Shave-off depth profiling: Depth profiling with an absolute depth scale

    International Nuclear Information System (INIS)

    Nojima, M.; Maekawa, A.; Yamamoto, T.; Tomiyasu, B.; Sakamoto, T.; Owari, M.; Nihei, Y.

    2006-01-01

    Shave-off depth profiling provides profiling with an absolute depth scale. This method uses a focused ion beam (FIB) micro-machining process to provide the depth profile. We show that the shave-off depth profile of a particle reflected the spherical shape of the sample and signal intensities had no relationship to the depth. Through the introduction of FIB micro-sampling, the shave-off depth profiling of a dynamic random access memory (DRAM) tip was carried out. The shave-off profile agreed with a blue print from the manufacturing process. Finally, shave-off depth profiling is discussed with respect to resolutions and future directions

  10. A Novel Index for Online Voltage Stability Assessment Based on Correlation Characteristic of Voltage Profiles

    Directory of Open Access Journals (Sweden)

    M. R. Aghamohammadi

    2011-06-01

    Full Text Available Abstract: Voltage instability is a major threat for security of power systems. Preserving voltage security margin at a certain limit is a vital requirement for today’s power systems. Assessment of voltage security margin is a challenging task demanding sophisticated indices. In this paper, for the purpose of on line voltage security assessment a new index based on the correlation characteristic of network voltage profile is proposed. Voltage profile comprising all bus voltages contains the effect of network structure, load-generation patterns and reactive power compensation on the system behaviour and voltage security margin. Therefore, the proposed index is capable to clearly reveal the effect of system characteristics and events on the voltage security margin. The most attractive feature for this index is its fast and easy calculation from synchronously measured voltage profile without any need to system modelling and simulation and without any dependency on network size. At any instant of system operation by merely measuring network voltage profile and no further simulation calculation this index could be evaluated with respect to a specific reference profile. The results show that the behaviour of this index with respect to the change in system security is independent of the selected reference profile. The simplicity and easy calculation make this index very suitable for on line application. The proposed approach has been demonstrated on IEEE 39 bus test system with promising results showing its effectiveness and applicability.

  11. Dosimetric considerations and radiation protection of patients in interventional cardiology

    International Nuclear Information System (INIS)

    Ciraj-Bjelac, O.; Arandjic, D.; Kosutic, D.; Loncar, B.

    2009-01-01

    The paper summarizes results of measurements of relevant dosimetric quantities in interventional cardiology. Dosimetric data were collected for 117 coronary angiography (CA) procedures, 69 percutaneous coronary interventions (PCI) and 41 combined procedures (CA+PCI), taking into account two quantities: air kerma area product (KAP) d air kerma in international reference point (K IRP ). Mean KAP values were 78 Gy·cm 2 , 113 Gy·cm 2 and 141 Gy·cm 2 for CA, PCI i CA+PCI, respectively. Corresponding mean K IRP values were 1.2 Gy, 1.8 Gy and 2.2 Gy. With respect to high dose values, risk for stochastic effects and tissue reactions, dose management methods were proposed. (author) [sr

  12. A new beam profile monitor and time of flight system for CologneAMS

    Energy Technology Data Exchange (ETDEWEB)

    Pascovici, G. [CologneAMS, University of Cologne (Germany); Dewald, A., E-mail: dewald@ikp.uni-koeln.de [CologneAMS, University of Cologne (Germany); Institute of Nuclear Physics, University of Cologne (Germany); Heinze, S., E-mail: heinze@ikp.uni-koeln.de [CologneAMS, University of Cologne (Germany); Fink, L.; Mueller-Gatermann, C.; Schiffer, M.; Feuerstein, C. [CologneAMS, University of Cologne (Germany); Pfeiffer, M.; Jolie, J.; Thiel, S.; Zell, K.O.; Arnopolina, O. [Institute of Nuclear Physics, University of Cologne (Germany); Blanckenburg, F. von [GFZ, German Research Centre for Geosciences, Potsdam (Germany)

    2013-01-15

    A complex beam detector consisting of a high-resolution beam profile monitor (BPM) and a time of flight (TOF) spectrometer with tracking capabilities was designed especially for the special needs of the Cologne center for accelerator mass spectrometry (CologneAMS). The beam detector assembly is designed to match the beam specifications of the 6 MV Tandetron AMS setup and its data acquisition system. It will have a reconfigurable structure, either as a fast TOF subsystem with a ca. 10 cm{sup 2} equivalent active area, or as a more complex BPM-TOF detector with beam tracking capabilities and a larger active area (16 cm{sup 2}). The purpose of this detector is to suppress background during spectrometry of heavy ions (U, Cm, Pu, Am etc.) and to suppress isobaric interferences such as {sup 36}S in {sup 36}Cl spectra.

  13. Specific autoantibody profiles and disease subgroups correlate with circulating micro-RNA in systemic sclerosis

    DEFF Research Database (Denmark)

    Wuttge, D. M.; Carlsen, A. L.; Teku, G.

    2015-01-01

    Objective. To evaluate the expression profiles of cell-free plasma miRNAs in SSc and to characterize their correlation with disease subgroups (lcSSc and dcSSc) and with autoantibody profiles. Methods. Using quantitative RT-PCR, the abundance of 45 mature miRNAs in plasma was determined in 95 pati...

  14. Quantitative sputter profiling at surfaces and interfaces

    International Nuclear Information System (INIS)

    Kirschner, J.; Etzkorn, H.W.

    1981-01-01

    The key problem in quantitative sputter profiling, that of a sliding depth scale has been solved by combined Auger/X-ray microanalysis. By means of this technique and for the model system Ge/Si (amorphous) the following questions are treated quantitatively: shape of the sputter profiles when sputtering through an interface and origin of their asymmetry; precise location of the interface plane on the depth profile; broadening effects due to limited depth of information and their correction; origin and amount of bombardment induced broadening for different primary ions and energies; depth dependence of the broadening, and basic limits to depth resolution. Comparisons are made to recent theoretical calculations based on recoil mixing in the collision cascade and very good agreement is found

  15. Natural gas annual 1993 supplement: Company profiles

    Energy Technology Data Exchange (ETDEWEB)

    1995-02-01

    The Natural Gas Annual provides information on the supply and disposition of natural gas to a wide audience including industry, consumers, Federal and State agencies, and educational institutions. This report, the Natural Gas Annual 1993 Supplement: Company Profiles, presents a detailed profile of 45 selected companies in the natural gas industry. The purpose of this report is to show the movement of natural gas through the various States served by the companies profiled. The companies in this report are interstate pipeline companies or local distribution companies (LDC`s). Interstate pipeline companies acquire gas supplies from company owned production, purchases from producers, and receipts for transportation for account of others. Pipeline systems, service area maps, company supply and disposition data are presented.

  16. Proceedings of the remedial investigation/feasibility study workshop

    International Nuclear Information System (INIS)

    1988-12-01

    The objective of this workshop was to familiarize Department of Energy (DOE) personnel and contractors with all aspects of developing, managing, and conducting an RI/FS, based on HAZWRAP SCO experience in similar activities as part of the Installation Restoration program (IRP). The HAZWRAP SCO participation in Department of Defense (DOD) restoration activities provides an opportunity to develop capability and experience which are transferable to DOE activities. Paul Franco, Program Manager for the IRP, provided an overview of the IRP experience in conducting an RI/FS for a National Priorities List (NPL) site and a non-NPL site. A non-NPL site does not require an RI/FS by regulation; however, the RI/FS process can be used to determine whether to proceed with a feasibility study or terminate the action with a decision document. Al Porell, Program Manager for ICP, discussed the use of decision documents to remove non-NPL sites from regulatory consideration. DOE-Idaho has used similar documentation to remove numerous sites from their list of potential remedial action sites. Mr. Porell also discussed the use of the Technical Review Committee (TRC), which is established to coordinate activities during the RI/FS process. The TRC includes state, local, and federal authorities, and Air Force installation personnel

  17. Designing cost effective water demand management programs in Australia.

    Science.gov (United States)

    White, S B; Fane, S A

    2002-01-01

    This paper describes recent experience with integrated resource planning (IRP) and the application of least cost planning (LCP) for the evaluation of demand management strategies in urban water. Two Australian case studies, Sydney and Northern New South Wales (NSW) are used in illustration. LCP can determine the most cost effective means of providing water services or alternatively the cheapest forms of water conservation. LCP contrasts to a traditional approach of evaluation which looks only at means of increasing supply. Detailed investigation of water usage, known as end-use analysis, is required for LCP. End-use analysis allows both rigorous demand forecasting, and the development and evaluation of conservation strategies. Strategies include education campaigns, increasing water use efficiency and promoting wastewater reuse or rainwater tanks. The optimal mix of conservation strategies and conventional capacity expansion is identified based on levelised unit cost. IRP uses LCP in the iterative process, evaluating and assessing options, investing in selected options, measuring the results, and then re-evaluating options. Key to this process is the design of cost effective demand management programs. IRP however includes a range of parameters beyond least economic cost in the planning process and program designs, including uncertainty, benefit partitioning and implementation considerations.

  18. Qualitative analysis of Th-232 in soil samples with portable radiological identifiers NaI (Tl) and LaBr{sub 3} (Ce); Análise qualitativa de Th-232 em amostras de solo com identificadores radiológicos portáteis NaI(Tl) e LaBr{sub 3}(Ce)

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira, L.S.R.; Amorim, A.S.; Balthar, M.C.V.; Vilela, P.RT.; Santos, A. [Instituto de Defesa, Química, Biológica, Radiológica e Nuclear (IDQBRN), Rio de Janeiro, RJ (Brazil); Cardoso, D.O.; Izidoro, A.C.A.C. [Instituto Militar de Engenharia (IME), Rio de Janeiro, RJ (Brazil); Pelegrineli, S.Q.; Silva, L.B.; Silva, S.L. [MAXIM Treinamento e Assessoria, Rio de Janeiro, RJ (Brazil); Santos, F.R.; Ribeiro, C.A.M.; Silva, D.C., E-mail: lucianosantarita@gmail.com, E-mail: domingosoliveiralvr71@gmail.com, E-mail: samuelfisica@yahoo.com.br [Universidade Estácio de Sá, Rio de Janeiro, RJ (Brazil)

    2017-07-01

    The identification of the occurrence of Th-232 in open environments using portable radiological identifiers (IRP) with scintillators, discriminating the environmental condition and NORM is important for the operational teams of the Institute of Chemical, Biological, Radiological and Nuclear Defense (IDQBRN) of the Army. The qualitative analysis by gamma energy spectrometry for the energies of Th-232 and its daughter radioisotopes, given the resolution that characterizes the scintillation crystals (NaI (Tl) - 7.5% and LaBr{sub 3} (Ce) - 2.9%) makes it possible to identify them. The purpose is to perform a qualitative analysis of the reliability of the response of these IRPs to the measurements of Th-232 generally found in the environment and in samples extracted from points where the thorium concentration is highest. The results show that the identification of this radionuclide by the IRP in the samples with the highest natural occurrence is achieved by measuring the energies of the daughter isotopes Ac-228, Tl-208, Bi-212 and Pb-212 allowing the discrimination of soils with natural occurrence of Th -232 and NORM. These measurements will be based on the procedures used by the operational teams in the field actions aimed at reducing exposure to this radiation, both for individuals occupationally exposed and for the population.

  19. Implementation of the integrated planning process of energy resources in the administrative region of the Aracatuba in Sao Paulo, Brazil; Implementacao do processo de planejamento integrado de recursos energeticos na regiao administrativa de Aracatuba no Estado de Sao Paulo

    Energy Technology Data Exchange (ETDEWEB)

    Bernal, Jonathas Luiz de Oliveira; Udaeta, Miguel Edgar Morales; Grimoni, Jose Aquiles Baesso [Universidade de Sao Paulo (IEE/USP), SP (Brazil). Inst. de Eletrotecnica e Energia; Galvao, Luiz Claudio Ribeiro [Universidade de Sao Paulo (GEPEA/USP), SP (Brazil). Dept. de Energia e Automacao Eletricas. Grupo de Energia

    2008-07-01

    The project 'Novos Instrumentos para o Planejamento Energetico Regional Visando o Desenvolvimento Sustentavel' considers, through the Integrated energy Resources Planning - IRP -, to identify to the necessities and strategical expectations for the region and the elaboration of business-oriented plans in distributed resources, to evaluate the economic potential of these resources and to develop strategical projects aiming to reach the sustainable development of the west region of Sao Paulo state. Structuralized to get information organized and reliable in order to help the decision being aimed at the sustainable development and evidencing the benefits of an ample or holistic vision suggested by the IRP, the methodology of work consider phases as the consolidation of resources and technologies, research of field, determination of the potential, accomplishment of the IRP with the evaluation of the complete costs (economical, environmental, social and political respects). The study of the region points at energy resources, as much for expansion of offers as for substitution of the existing ones, considering its social, environmental respects as much as economical and political, placing them of form if to classify in space, through the geo-referring; and classifying them qualitatively, taking itself in account all characteristics previously raised. (author)

  20. Profiling Occupant Behaviour in Danish Dwellings using Time Use Survey Data - Part I: Data Description and Activity Profiling

    DEFF Research Database (Denmark)

    Barthelmes, V.M.; Li, R.; Andersen, R.K.

    2018-01-01

    Occupant behaviour has been shown to be one of the key driving factors of uncertainty in prediction of energy consumption in buildings. Building occupants affect building energy use directly and indirectly by interacting with building energy systems such as adjusting temperature set...... occupant profiles for prediction of energy use to reduce the gap between predicted and real building energy consumptions. To generate accurate occupant profiles for the residential sector in Denmark, the Danish time use surveys are considered an essential data source. The latest Danish diarybased time use......-points, switching lights on/off, using electrical devices and opening/closing windows. Furthermore, building inhabitants’ daily activity profiles clearly shape the timing of energy demand in households. Modelling energy-related human activities throughout the day, therefore, is crucial to defining more realistic...

  1. Approximate Stokes Drift Profiles and their use in Ocean Modelling

    Science.gov (United States)

    Breivik, Oyvind; Bidlot, Jea-Raymond; Janssen, Peter A. E. M.; Mogensen, Kristian

    2016-04-01

    Deep-water approximations to the Stokes drift velocity profile are explored as alternatives to the monochromatic profile. The alternative profiles investigated rely on the same two quantities required for the monochromatic profile, viz the Stokes transport and the surface Stokes drift velocity. Comparisons against parametric spectra and profiles under wave spectra from the ERA-Interim reanalysis and buoy observations reveal much better agreement than the monochromatic profile even for complex sea states. That the profiles give a closer match and a more correct shear has implications for ocean circulation models since the Coriolis-Stokes force depends on the magnitude and direction of the Stokes drift profile and Langmuir turbulence parameterizations depend sensitively on the shear of the profile. Of the two Stokes drift profiles explored here, the profile based on the Phillips spectrum is by far the best. In particular, the shear near the surface is almost identical to that influenced by the f-5 tail of spectral wave models. The NEMO general circulation ocean model was recently extended to incorporate the Stokes-Coriolis force along with two other wave-related effects. The ECWMF coupled atmosphere-wave-ocean ensemble forecast system now includes these wave effects in the ocean model component (NEMO).

  2. Profiles of mental health care professionals based on work role performance.

    Science.gov (United States)

    Markon, Marie-Pierre; Bamvita, Jean-Marie; Chiocchio, François; Fleury, Marie-Josée

    2017-12-01

    The worldwide burden of mental disorders is considerable, and on the rise, putting pressure on health care systems. Current reforms aim to improve the efficiency of mental health care systems by increasing service integration in communities and strengthening primary mental health care. In this context, mental health care professionals (MHPs) are increasingly required to work on interdisciplinary teams in a variety of settings. Little is known, however, about the profiles of MHPs in relation to their perceived work role performance. MHPs in Quebec (N = 315) from four local service networks completed a self-administered questionnaire eliciting information on individual and team characteristics, as well as team processes and states. Profiles of MHPs were created using a two-step cluster analysis. Five profiles were generated. MHPs belonging to profiles labelled senior medical outpatient specialized care MHPs and senior psychosocial outpatient specialized care MHPs perceived themselves as more performing than MHPs in other profiles. The profile labelled low-collaborators was significantly less performing than all other groups. Two other profiles were identified, positioned between the aforementioned groups in terms of the perceived performance of MHPs: the junior primary care MHPs and the diversified specialized care MHPs. Seniority within the team, delivering specialized type of care, and positive team processes were all features associated with profiles where perceived work performance was high. Overall, this study supports the case for initiatives aimed at improving stability and interdisciplinary collaboration in health teams, especially in primary care.

  3. Searching mixed DNA profiles directly against profile databases.

    Science.gov (United States)

    Bright, Jo-Anne; Taylor, Duncan; Curran, James; Buckleton, John

    2014-03-01

    DNA databases have revolutionised forensic science. They are a powerful investigative tool as they have the potential to identify persons of interest in criminal investigations. Routinely, a DNA profile generated from a crime sample could only be searched for in a database of individuals if the stain was from single contributor (single source) or if a contributor could unambiguously be determined from a mixed DNA profile. This meant that a significant number of samples were unsuitable for database searching. The advent of continuous methods for the interpretation of DNA profiles offers an advanced way to draw inferential power from the considerable investment made in DNA databases. Using these methods, each profile on the database may be considered a possible contributor to a mixture and a likelihood ratio (LR) can be formed. Those profiles which produce a sufficiently large LR can serve as an investigative lead. In this paper empirical studies are described to determine what constitutes a large LR. We investigate the effect on a database search of complex mixed DNA profiles with contributors in equal proportions with dropout as a consideration, and also the effect of an incorrect assignment of the number of contributors to a profile. In addition, we give, as a demonstration of the method, the results using two crime samples that were previously unsuitable for database comparison. We show that effective management of the selection of samples for searching and the interpretation of the output can be highly informative. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  4. Director, Laboratory Animal Care and Use Section

    Data.gov (United States)

    Federal Laboratory Consortium — The NIAMS Laboratory Animal Care and Use Section (LACU) provides support to all NIAMS Intramural Research Program (IRP) Branches and Laboratories using animals. The...

  5. Homogenization of the lipid profile values.

    Science.gov (United States)

    Pedro-Botet, Juan; Rodríguez-Padial, Luis; Brotons, Carlos; Esteban-Salán, Margarita; García-Lerín, Aurora; Pintó, Xavier; Lekuona, Iñaki; Ordóñez-Llanos, Jordi

    Analytical reports from the clinical laboratory are essential to guide clinicians about what lipid profile values should be considered altered and, therefore, require intervention. Unfortunately, there is a great heterogeneity in the lipid values reported as "normal, desirable, recommended or referenced" by clinical laboratories. This can difficult clinical decisions and be a barrier to achieve the therapeutic goals for cardiovascular prevention. A recent international recommendation has added a new heterogeneity factor for the interpretation of lipid profile, such as the possibility of measuring it without previous fasting. All this justifies the need to develop a document that adapts the existing knowledge to the clinical practice of our health system. In this regard, professionals from different scientific societies involved in the measurement and use of lipid profile data have developed this document to establish recommendations that facilitate their homogenization. Copyright © 2017. Publicado por Elsevier España, S.L.U.

  6. 40 CFR 141.172 - Disinfection profiling and benchmarking.

    Science.gov (United States)

    2010-07-01

    ... benchmarking. 141.172 Section 141.172 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... Disinfection-Systems Serving 10,000 or More People § 141.172 Disinfection profiling and benchmarking. (a... sanitary surveys conducted by the State. (c) Disinfection benchmarking. (1) Any system required to develop...

  7. Automated real-time search and analysis algorithms for a non-contact 3D profiling system

    Science.gov (United States)

    Haynes, Mark; Wu, Chih-Hang John; Beck, B. Terry; Peterman, Robert J.

    2013-04-01

    The purpose of this research is to develop a new means of identifying and extracting geometrical feature statistics from a non-contact precision-measurement 3D profilometer. Autonomous algorithms have been developed to search through large-scale Cartesian point clouds to identify and extract geometrical features. These algorithms are developed with the intent of providing real-time production quality control of cold-rolled steel wires. The steel wires in question are prestressing steel reinforcement wires for concrete members. The geometry of the wire is critical in the performance of the overall concrete structure. For this research a custom 3D non-contact profilometry system has been developed that utilizes laser displacement sensors for submicron resolution surface profiling. Optimizations in the control and sensory system allow for data points to be collected at up to an approximate 400,000 points per second. In order to achieve geometrical feature extraction and tolerancing with this large volume of data, the algorithms employed are optimized for parsing large data quantities. The methods used provide a unique means of maintaining high resolution data of the surface profiles while keeping algorithm running times within practical bounds for industrial application. By a combination of regional sampling, iterative search, spatial filtering, frequency filtering, spatial clustering, and template matching a robust feature identification method has been developed. These algorithms provide an autonomous means of verifying tolerances in geometrical features. The key method of identifying the features is through a combination of downhill simplex and geometrical feature templates. By performing downhill simplex through several procedural programming layers of different search and filtering techniques, very specific geometrical features can be identified within the point cloud and analyzed for proper tolerancing. Being able to perform this quality control in real time

  8. Profiles

    International Nuclear Information System (INIS)

    2004-01-01

    Profiles is a synthetic overview of more than 100 national energy markets in the world, providing insightful facts and key energy statistics. A Profile is structured around 6 main items and completed by key statistics: Ministries, public agencies, energy policy are concerned; main companies in the oil, gas, electricity and coal sectors, status, shareholders; reserve, production, imports and exports, electricity and refining capacities; deregulation of prices, subsidies, taxes; consumption trends by sector, energy market shares; main energy projects, production and consumption prospects. Statistical Profiles are present in about 3 pages the main data and indicators on oil, gas, coal and electricity. (A.L.B.)

  9. Network-based analysis of proteomic profiles

    KAUST Repository

    Wong, Limsoon

    2016-01-26

    Mass spectrometry (MS)-based proteomics is a widely used and powerful tool for profiling systems-wide protein expression changes. It can be applied for various purposes, e.g. biomarker discovery in diseases and study of drug responses. Although RNA-based high-throughput methods have been useful in providing glimpses into the underlying molecular processes, the evidences they provide are indirect. Furthermore, RNA and corresponding protein levels have been known to have poor correlation. On the other hand, MS-based proteomics tend to have consistency issues (poor reproducibility and inter-sample agreement) and coverage issues (inability to detect the entire proteome) that need to be urgently addressed. In this talk, I will discuss how these issues can be addressed by proteomic profile analysis techniques that use biological networks (especially protein complexes) as the biological context. In particular, I will describe several techniques that we have been developing for network-based analysis of proteomics profile. And I will present evidence that these techniques are useful in identifying proteomics-profile analysis results that are more consistent, more reproducible, and more biologically coherent, and that these techniques allow expansion of the detected proteome to uncover and/or discover novel proteins.

  10. A novel non-contact profiler design for measuring synchrotron radiation mirrors

    International Nuclear Information System (INIS)

    Lin, Yao; Takacs, P.Z.; Furenlid, K.; DeBiasse, R.A.; Wang, Run-Wen

    1990-08-01

    A novel optical profiler is described in this paper for measurement of surface profiles of synchrotron radiation (SR) mirrors. The measurement is based on a combination of an optical heterodyne technique and a precise phase measurement procedure without a reference surface. A Zeeman two-frequency He-Ne laser is employed as the light source. The common-path optical system, which uses a birefringent lens as the beam splitter, minimizes the effects of air turbulence, sample vibration and temperature variation. A special autofocus system allows the profiler to measure the roughness and shape of a sample surface. The optical system is mounted on a large linear air-bearing slide, and is capable of scanning over distances covering the spatial period range from several microns to nearly one meter with a high measurement accuracy. 9 refs., 5 figs

  11. Assimilation of Atmospheric InfraRed Sounder (AIRS) Profiles using WRF-Var

    Science.gov (United States)

    Zavodsky, Brad; Jedlovec, Gary J.; Lapenta, William

    2008-01-01

    The Weather Research and Forecasting (WRF) model contains a three-dimensional variational (3DVAR) assimilation system (WRF-Var), which allows a user to join data from multiple sources into one coherent analysis. WRF-Var combines observations with a background field traditionally generated using a previous model forecast through minimization of a cost function. In data sparse regions, remotely-sensed observations may be able to improve analyses and produce improved forecasts. One such source comes from the Atmospheric Infrared Sounder (AIRS), which together with the Advanced Microwave Sounding Unit (AMSU), represents one of the most advanced space-based atmospheric sounding systems. The combined AIRS/AMSU system provides radiance measurements used as input to a sophisticated retrieval scheme which has been shown to produce temperature profiles with an accuracy of 1 K over 1 km layers and humidity profiles with accuracy of 15% in 2 km layers in both clear and partly cloudy conditions. The retrieval algorithm also provides estimates of the accuracy of the retrieved values at each pressure level, allowing the user to select profiles based on the required error tolerances of the application. The purpose of this paper is to describe a procedure to optimally assimilate high-resolution AIRS profile data into a regional configuration of the Advanced Research WRF (ARW) version 2.2 using WRF-Var. The paper focuses on development of background error covariances for the regional domain and background field type using gen_be and an optimal methodology for ingesting AIRS temperature and moisture profiles as separate overland and overwater retrievals with different error characteristics in the WRF-Var. The AIRS thermodynamic profiles are obtained from the version 5.0 Earth Observing System (EOS) science team retrieval algorithm and contain information about the quality of each temperature layer. The quality indicators are used to select the highest quality temperature and moisture

  12. An Interoperability Framework and Capability Profiling for Manufacturing Software

    Science.gov (United States)

    Matsuda, M.; Arai, E.; Nakano, N.; Wakai, H.; Takeda, H.; Takata, M.; Sasaki, H.

    ISO/TC184/SC5/WG4 is working on ISO16100: Manufacturing software capability profiling for interoperability. This paper reports on a manufacturing software interoperability framework and a capability profiling methodology which were proposed and developed through this international standardization activity. Within the context of manufacturing application, a manufacturing software unit is considered to be capable of performing a specific set of function defined by a manufacturing software system architecture. A manufacturing software interoperability framework consists of a set of elements and rules for describing the capability of software units to support the requirements of a manufacturing application. The capability profiling methodology makes use of the domain-specific attributes and methods associated with each specific software unit to describe capability profiles in terms of unit name, manufacturing functions, and other needed class properties. In this methodology, manufacturing software requirements are expressed in terns of software unit capability profiles.

  13. National Profiles in Technical and Vocational Education in Asia and the Pacific: Bhutan.

    Science.gov (United States)

    United Nations Educational, Scientific and Cultural Organization, Bangkok (Thailand). Principal Regional Office for Asia and the Pacific.

    This technical and vocational education (TVE) profile on Bhutan is one in a series of profiles of UNESCO member countries. It is intended to be a handy reference on TVE systems, staff development, technical cooperation, and information networking. Part I, Policy Concern, provides general information on the education delivery system, the role of…

  14. UAV-Borne Profiling Radar for Forest Research

    Directory of Open Access Journals (Sweden)

    Yuwei Chen

    2017-01-01

    Full Text Available Microwave Radar is an attractive solution for forest mapping and inventories because microwave signals penetrates into the forest canopy and the backscattering signal can provide information regarding the whole forest structure. Satellite-borne and airborne imaging radars have been used in forest resources mapping for many decades. However, their accuracy with respect to the main forest inventory attributes substantially varies depending on the wavelength and techniques used in the estimation. Systems providing canopy backscatter as a function of canopy height are, practically speaking, missing. Therefore, there is a need for a radar system that would enable the scientific community to better understand the radar backscatter response from the forest canopy. Consequently, we undertook a research study to develop an unmanned aerial vehicle (UAV-borne profiling (i.e., waveform radar that could be used to improve the understanding of the radar backscatter response for forestry mapping and inventories. A frequency modulation continuous waveform (FMCW profiling radar, termed FGI-Tomoradar, was introduced, designed and tested. One goal is the total weight of the whole system is less than 7 kg, including the radar system and georeferencing system, with centimetre-level positioning accuracy. Achieving this weight goal would enable the FGI-Tomoradar system to be installed on the Mini-UAV platform. The prototype system had all four linear polarization measuring capabilities, with bistatic configuration in Ku-band. In system performance tests in this study, FGI-Tomoradar was mounted on a manned helicopter together with a Riegl VQ-480-U laser scanner and tested in several flight campaigns performed at the Evo site, Finland. Airborne laser scanning data was simultaneously collected to investigate the differences and similarities of the outputs for the same target area for better understanding the penetration of the microwave signal into the forest canopy

  15. Dynamics and profiles of a diffusive host-pathogen system with distinct dispersal rates

    Science.gov (United States)

    Wu, Yixiang; Zou, Xingfu

    2018-04-01

    In this paper, we investigate a diffusive host-pathogen model with heterogeneous parameters and distinct dispersal rates for the susceptible and infected hosts. We first prove that the solution of the model exists globally and the model system possesses a global attractor. We then identify the basic reproduction number R0 for the model and prove its threshold role: if R0 ≤ 1, the disease free equilibrium is globally asymptotically stable; if R0 > 1, the solution of the model is uniformly persistent and there exists a positive (pathogen persistent) steady state. Finally, we study the asymptotic profiles of the positive steady state as the dispersal rate of the susceptible or infected hosts approaches zero. Our result suggests that the infected hosts concentrate at certain points which can be characterized as the pathogen's most favoured sites when the mobility of the infected host is limited.

  16. Real time n/γ discrimination for the JET neutron profile monitor

    Energy Technology Data Exchange (ETDEWEB)

    Riva, M., E-mail: marco.riva@enea.it [Associazione EURATOM-ENEA sulla Fusione, C.P. 65, Frascati I-00044, Roma (Italy); Esposito, B.; Marocco, D.; Belli, F. [Associazione EURATOM-ENEA sulla Fusione, C.P. 65, Frascati I-00044, Roma (Italy); Syme, B. [EURATOM/CCFE Fusion Association, OX14 3DB Abingdon (United Kingdom); Giacomelli, L. [Dipartimento di Fisica, Università degli Studi di Milano-Bicocca (Italy); Istituto di Fisica del Plasma, Associazione EURATOM-ENEA-CNR, 20100 Milano (Italy); JET-EFDA, Culham Science Centre, OX14 3DB Abingdon (United Kingdom)

    2013-10-15

    Highlights: ► Development of a pulse oriented acquisition system able for the JET neutron profile monitor to separate neutron and gamma pulses. ► Description of the FPGA hardware architecture. ► Comparison between the off-line and real time neutron count rates from the last JET experimental campaign. ► Estimate of the maximum sustainable count rate of the system. ► Statistical analysis of neutron measurements from JET neutron profile monitor and neutron monitors. -- Abstract: The JET neutron profile monitor provides the measurement of the neutron flux along 19 collimated lines of sight from which the neutron emissivity profile can be obtained through reconstruction based on inversion methods. The neutron detectors are liquid organic scintillators featuring n/γ pulse shape discrimination. A recent digital upgrade of the neutron profile monitor acquisition system (200 MSamples/s sampling rate per channel, 14 bit resolution) offers new real-time capabilities. An algorithm performing real-time n/γ discrimination by means of the charge comparison method is implemented in the acquisition system FPGA. The algorithm produces two distinct count rates (n and γ) that are sent to the JET real time network ready for control applications and are simultaneously stored into the JET archive together with all the samples of each pulse. The paper describes the architecture of the FPGA implementation and reports the analysis of data collected during the 2011–2012 JET campaigns. The comparison between the real-time and post-processed (off-line) neutron count rates shows an agreement within 5% for all 19 detectors. Moreover, it is shown that the maximum count rate sustainable by the acquisition system when storing raw data (∼900 kHz as evaluated in laboratory tests) can be extended up to 5 MHz when using the real-time implementation with no local data storage. Finally, a statistical analysis of the ratio between the line-integrated measurements from the neutron profile

  17. Modeling of Changing Electrode Profiles

    Energy Technology Data Exchange (ETDEWEB)

    Prentice, Geoffrey Allen [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Materials and Molecular Research Division; Univ. of California, Berkeley, CA (United States). Dept. of Chemical Engineering

    1980-12-01

    A model for simulating the transient behavior of solid electrodes undergoing deposition or dissolution has been developed. The model accounts for ohmic drop, charge transfer overpotential, and mass transport limitations. The finite difference method, coupled with successive overrelaxation, was used as the basis of the solution technique. An algorithm was devised to overcome the computational instabilities associated with the calculations of the secondary and tertiary current distributions. Simulations were performed on several model electrode profiles: the sinusoid, the rounded corner, and the notch. Quantitative copper deposition data were obtained in a contoured rotating cylinder system, Sinusoidal cross-sections, machined on stainless steel cylinders, were used as model geometries, Kinetic parameters for use in the simulation were determined from polarization curves obtained on copper rotating cylinders, These parameters, along with other physical property and geometric data, were incorporated in simulations of growing sinusoidal profiles. The copper distributions on the sinusoidal cross-sections were measured and found to compare favorably with the simulated results. At low Wagner numbers the formation of a slight depression at the profile peak was predicted by the simulation and observed on the profile. At higher Wagner numbers, the simulated and experimental results showed that the formation of a depression was suppressed. This phenomenon was shown to result from the competition between ohmic drop and electrode curvature.

  18. Accurate, fully-automated NMR spectral profiling for metabolomics.

    Directory of Open Access Journals (Sweden)

    Siamak Ravanbakhsh

    Full Text Available Many diseases cause significant changes to the concentrations of small molecules (a.k.a. metabolites that appear in a person's biofluids, which means such diseases can often be readily detected from a person's "metabolic profile"-i.e., the list of concentrations of those metabolites. This information can be extracted from a biofluids Nuclear Magnetic Resonance (NMR spectrum. However, due to its complexity, NMR spectral profiling has remained manual, resulting in slow, expensive and error-prone procedures that have hindered clinical and industrial adoption of metabolomics via NMR. This paper presents a system, BAYESIL, which can quickly, accurately, and autonomously produce a person's metabolic profile. Given a 1D 1H NMR spectrum of a complex biofluid (specifically serum or cerebrospinal fluid, BAYESIL can automatically determine the metabolic profile. This requires first performing several spectral processing steps, then matching the resulting spectrum against a reference compound library, which contains the "signatures" of each relevant metabolite. BAYESIL views spectral matching as an inference problem within a probabilistic graphical model that rapidly approximates the most probable metabolic profile. Our extensive studies on a diverse set of complex mixtures including real biological samples (serum and CSF, defined mixtures and realistic computer generated spectra; involving > 50 compounds, show that BAYESIL can autonomously find the concentration of NMR-detectable metabolites accurately (~ 90% correct identification and ~ 10% quantification error, in less than 5 minutes on a single CPU. These results demonstrate that BAYESIL is the first fully-automatic publicly-accessible system that provides quantitative NMR spectral profiling effectively-with an accuracy on these biofluids that meets or exceeds the performance of trained experts. We anticipate this tool will usher in high-throughput metabolomics and enable a wealth of new applications of

  19. Karolinske psychodynamic profile (KAPP)

    DEFF Research Database (Denmark)

    Mathiesen, Birgit Bork; Søgaard, Ulf

    2006-01-01

    psykologiske testmetoder, assesment, Karolinska psychodynamic profile (KAPP), psykodynamisk profil......psykologiske testmetoder, assesment, Karolinska psychodynamic profile (KAPP), psykodynamisk profil...

  20. Antibiotic susceptibility profiles of oral pathogens

    NARCIS (Netherlands)

    Veloo, A. C. M.; Seme, K.; Raangs, Gerwin; Rurenga, P.; Singadji, Z.; Wekema - Mulder, G.; van Winkelhoff, A. J.

    2012-01-01

    Periodontitis is a bacterial disease that can be treated with systemic antibiotics. The aim of this study was to establish the antibiotic susceptibility profiles of five periodontal pathogens to six commonly used antibiotics in periodontics. A total of 247 periodontal bacterial isolates were tested

  1. Comparison of RASS temperature profiles with other tropospheric soundings

    International Nuclear Information System (INIS)

    Bonino, G.; Lombardini, P.P.; Trivero, P.

    1980-01-01

    The vertical temperature profile of the lower troposphere can be measured with a radio-acoustic sounding system (RASS). A comparison of the thermal profiles measured with the RASS and with traditional methods shows a) RASS ability to produce vertical thermal profiles at an altitude range of 170 to 1000 m with temperature accuracy and height discrimination comparable with conventional soundings, b) advantages of remote sensing as offered by new sounder, c) applicability of RASS both in assessing evolution of thermodynamic conditions in PBL and in sensing conditions conducive to high concentrations of air pollutants at the ground level. (author)

  2. Radiation profile measurements for edge transport barrier discharges in Compact Helical System using AXUV photodiode arrays

    International Nuclear Information System (INIS)

    Suzuki, C.; Okamura, S.; Minami, T.; Akiyama, T.; Fujisawa, A.; Ida, K.; Isobe, M.; Matsuoka, K.; Nagaoka, K.; Nishimura, S.; Peterson, B. J.; Shimizu, A.; Takahashi, C.; Toi, K.; Yoshimura, Y.

    2005-01-01

    The formation of edge transport barrier (ETB) has recently been found in Compact Helical System (CHS) plasmas heated by co-injected neutral beam injection (NBI) with strong gas puffing. This regime is characterized by the appearance of the steep gradient of the electron density near the edge following the abrupt drop of hydrogen Balmer alpha (H α ) line intensity. In addition to single channel pyroelectric detector as a conventional bolometer, we have employed unfiltered absolute extreme ultraviolet (AXUV) photodiode arrays as a simple and low-cost diagnostic to investigate spatial and temporal variations of radiation emissivity in the ETB discharges. A compact mounting module for a 20 channel AXUV photodiode array including an in-vacuum preamplifier for immediate current-voltage conversion has successfully been designed and fabricated. Two identical modules installed in the upper and lower viewports provide 40 lines of sight covering the inboard and outboard sides within the horizontally elongated cross section of the CHS plasma with wide viewing angle. Although spectral uniformity of the detector sensitivity of the AXUV photodiode is unsatisfied for photon energies lower than 200 eV, it has been confirmed that the signals of AXUV photodiode and pyroelectric detector in the ETB discharges show roughly the same behavior except for the very beginning and end of the discharges. The results of the measurements in typical ETB discharges show that the signals of all the channels of the AXUV photodiode arrays begin to increase more rapidly at the moment of the transition than before. The rate of the increase is larger for the edge viewing chords than for the center viewing ones, which indicates the flattening of the radiation profile following the change in the electron density profile after the formation of the ETB. However, the signals for the edge chords tend to saturate after several tens of milliseconds, while they still continue to increase for the central chords

  3. 915-MHz Radar Wind Profiler (915RWP) Handbook

    Energy Technology Data Exchange (ETDEWEB)

    Coulter, R

    2005-01-01

    The 915 MHz radar wind profiler/radio acoustic sounding system (RWP/RASS) measures wind profiles and backscattered signal strength between (nominally) 0.1 km and 5 km and virtual temperature profiles between 0.1 km and 2.5 km. It operates by transmitting electromagnetic energy into the atmosphere and measuring the strength and frequency of backscattered energy. Virtual temperatures are recovered by transmitting an acoustic signal vertically and measuring the electromagnetic energy scattered from the acoustic wavefront. Because the propagation speed of the acoustic wave is proportional to the square root of the virtual temperature of the air, the virtual temperature can be recovered by measuring the Doppler shift of the scattered electromagnetic wave.

  4. Earth-mass haloes and the emergence of NFW density profiles

    Science.gov (United States)

    Angulo, Raul E.; Hahn, Oliver; Ludlow, Aaron D.; Bonoli, Silvia

    2017-11-01

    We simulate neutralino dark matter (χDM) haloes from their initial collapse, at ˜ earth mass, up to a few percent solar. Our results confirm that the density profiles of the first haloes are described by a ˜r-1.5 power law. As haloes grow in mass, their density profiles evolve significantly. In the central regions, they become shallower and reach on average ˜r-1, the asymptotic form of an NFW profile. Using non-cosmological controlled simulations, we observe that temporal variations in the gravitational potential caused by major mergers lead to a shallowing of the inner profile. This transformation is more significant for shallower initial profiles and for a higher number of merging systems. Depending on the merger details, the resulting profiles can be shallower or steeper than NFW in their inner regions. Interestingly, mergers have a much weaker effect when the profile is given by a broken power law with an inner slope of -1 (such as NFW or Hernquist profiles). This offers an explanation for the emergence of NFW-like profiles: after their initial collapse, r-1.5 χDM haloes suffer copious major mergers, which progressively shallows the profile. Once an NFW-like profile is established, subsequent merging does not change the profile anymore. This suggests that halo profiles are not universal but rather a combination of (1) the physics of the formation of the microhaloes and (2) their early merger history - both set by the properties of the dark matter particle - as well as (3) the resilience of NFW-like profiles to perturbations.

  5. Temporal Texture Profile and Identification of Glass Transition Temperature as an Instrumental Predictor of Stickiness in a Caramel System.

    Science.gov (United States)

    Mayhew, Emily J; Schmidt, Shelly J; Schlich, Pascal; Lee, Soo-Yeun

    2017-09-01

    Stickiness is an important texture attribute in many food systems, but its meaning can vary by person, product, and throughout mastication. This variability and complexity makes it difficult to devise analytical tests that accurately and consistently predict sensory stickiness. Glass transition temperature (T g ) is a promising candidate for texture prediction. Our objective is to elucidate the temporal profile of stickiness in order to probe the relationship between T g and dynamic stickiness perception. Nine caramel samples with diverse texture and thermal profiles were produced for sensory testing and differential scanning calorimetry. Sixteen trained panelists generated stickiness-relevant terms to be used in a subsequent temporal dominance of sensation (TDS) test with the same panelists. Following the TDS study, these panelists also rated samples for overall tactile and oral stickiness. Stickiness ratings were then correlated to TDS dominance parameters across the full evaluation period and within the first, middle, and final thirds of the evaluation period. Samples with temporal texture profiles dominated by tacky, stringy, and enveloping attributes consistently received the highest stickiness scores, although the correlation strength varied by time period. T g was found to correlate well with trained panelist and consumer ratings of oral (R 2 trained = 0.85; R 2 consumer = 0.96) and tactile (R 2 trained = 0.78; R 2 consumer = 0.79) stickiness intensity, and stickiness intensity ratings decreased with T g of completely amorphous samples. Further, glassy samples followed a different texture trajectory (brittle-cohesive-toothpacking) than rubbery samples (deformable-tacky-enveloping). These results illuminate the dynamic perception of stickiness and support the potential of T g to predict both stickiness intensity and texture trajectory in caramel systems. © 2017 Institute of Food Technologists®.

  6. Assessing Basal and Acute Autophagic Responses in the Adult Drosophila Nervous System: The Impact of Gender, Genetics and Diet on Endogenous Pathway Profiles.

    Directory of Open Access Journals (Sweden)

    Eric P Ratliff

    Full Text Available The autophagy pathway is critical for the long-term homeostasis of cells and adult organisms and is often activated during periods of stress. Reduced pathway efficacy plays a central role in several progressive neurological disorders that are associated with the accumulation of cytotoxic peptides and protein aggregates. Previous studies have shown that genetic and transgenic alterations to the autophagy pathway impacts longevity and neural aggregate profiles of adult Drosophila. In this study, we have identified methods to measure the acute in vivo induction of the autophagy pathway in the adult fly CNS. Our findings indicate that the genotype, age, and gender of adult flies can influence pathway responses. Further, we demonstrate that middle-aged male flies exposed to intermittent fasting (IF had improved neuronal autophagic profiles. IF-treated flies also had lower neural aggregate profiles, maintained more youthful behaviors and longer lifespans, when compared to ad libitum controls. In summary, we present methodology to detect dynamic in vivo changes that occur to the autophagic profiles in the adult Drosophila CNS and that a novel IF-treatment protocol improves pathway response in the aging nervous system.

  7. THE IMPORTANCE OF INFORMATION IN SUPERIOR GRADUATING INSTITUTES WEBSITES, IN THE MATRIX CURRICULUM AND PROFESSIONAL PROFILE OF SYSTEMS ANALYSIS AND DEVELOPMENT COURSES

    Directory of Open Access Journals (Sweden)

    José Carlos Mariano do Carmo

    2018-04-01

    Full Text Available Introduction: the existing information in the technological graduation course official web pages need to be clear and objective, in order to ease up the access to programmatic contents, workload, integration and other necessary knowledge so that the students have discernment in their formation choice. Objective: to analyze the curriculum matrix and professional profile in the superior courses in Systems Analysis and Development in the Metropolitan Region of Florianópolis - Santa Catarina, considering the microregion of Grande Florianópolis, composed by nine counties: Florianópolis, São José, Palhoça, Biguaçu, Santo Amaro da Imperatriz, Governador Celso Ramos, Antônio Carlos, Águas Mornas and São Pedro de Alcântara. Methodology: we have performed a qualitative research on the pointed issue, relating it to the current legislation and some of the proposed theories. The research documentally based as it focused on the topics mentioned by the Superior Graduation Institutions in their virtual course environment. It was also used semistructured interviews by phone contact and even visiting when necessary, including searches in the Education Ministry web site to base the study, the curriculum matrix comparison and the course professional profile. Results: results show that the analyzed courses are focused in the job market demands in the studied region, regarding the desktop, web and mobile development solutions using programming languages. The formation professional profile also involves knowledge about logical reasoning, abstract math and learning of a second language. Conclusions: to show to interested students in joining the Systems Analysis and Development course, about the importance of the disciplines approached, utilized technologies, professional profiles and the main educational characteristics offered by the institutions. It is thus intended to contribute that these information are used for the purpose of qualification for the job

  8. Profile: Asian Americans

    Science.gov (United States)

    ... and Data > Minority Population Profiles > Asian American Profile: Asian Americans Asian American Profile (Map of the US with the top 10 states displaying the largest Asian American population according to the Census Bureau) CA - ...

  9. The Cloud-Aerosol Transport System (CATS): A New Lidar for Aerosol and Cloud Profiling from the International Space Station

    Science.gov (United States)

    Welton, Ellsworth J.; McGill, Mathew J.; Yorks. John E.; Hlavka, Dennis L.; Hart, William D.; Palm, Stephen P.; Colarco, Peter R.

    2012-01-01

    Spaceborne lidar profiling of aerosol and cloud layers has been successfully implemented during a number of prior missions, including LITE, ICESat, and CALIPSO. Each successive mission has added increased capability and further expanded the role of these unique measurements in wide variety of applications ranging from climate, to air quality, to special event monitoring (ie, volcanic plumes). Many researchers have come to rely on the availability of profile data from CALIPSO, especially data coincident with measurements from other A-Train sensors. The CALIOP lidar on CALIPSO continues to operate well as it enters its fifth year of operations. However, active instruments have more limited lifetimes than their passive counterparts, and we are faced with a potential gap in lidar profiling from space if the CALIOP lidar fails before a new mission is operational. The ATLID lidar on EarthCARE is not expected to launch until 2015 or later, and the lidar component of NASA's proposed Aerosols, Clouds, and Ecosystems (ACE) mission would not be until after 2020. Here we present a new aerosol and cloud lidar that was recently selected to provide profiling data from the International Space Station (ISS) starting in 2013. The Cloud-Aerosol Transport System (CATS) is a three wavelength (1064,532,355 nm) elastic backscatter lidar with HSRL capability at 532 nm. Depolarization measurements will be made at all wavelengths. The primary objective of CATS is to continue the CALIPSO aerosol and cloud profile data record, ideally with overlap between both missions and EarthCARE. In addition, the near real time (NRT) data capability ofthe ISS will enable CATS to support operational applications such as aerosol and air quality forecasting and special event monitoring. The HSRL channel will provide a demonstration of technology and a data testbed for direct extinction retrievals in support of ACE mission development. An overview of the instrument and mission will be provided, along with a

  10. Study on profile measurement of extruding tire tread by laser

    Science.gov (United States)

    Wang, LiangCai; Zhang, Wanping; Zhu, Weihu

    1996-10-01

    This paper presents a new 2D measuring system-profile measurement of extruding tire tread by laser. It includes the thickness measurement of extruding tire tread by laser and the width measurement of extruding tire tread using Moire Fringe. The system has been applied to process line of extruding tire tread. Two measuring results have been obtained. One is a standard profile picture of extruding tire tread including seven measuring values. Another one is a series of thickness and width values. When the scanning speed thickness range is thickness < +/- 0.1mm.

  11. Profile relaxation and tilt instability in a field-reversed configuration

    International Nuclear Information System (INIS)

    Ohtani, H.; Horiuchi, R.; Sato, T.

    2003-01-01

    The profile relaxation from a magnetic hydrodynamic (MHD) profile to a kinetic equilibrium in field-reversed configurations (FRCs) is investigated by two-dimensional electromagnetic particle simulation. The radial oscillation takes place in order to relax an excess energy in the MHD profile, and the system spontaneously relaxes toward a kinetic equilibrium. In this kinetic equilibrium, the hollow electron current profile is realized as a result of the combined effects of the single particle orbits and the ion finite Larmor radius, and the ion current profile becomes peaked due to the effect of the ion meandering motion. Three-dimensional full electromagnetic particle simulation is also performed to study the stability of these kinetic equilibrium against the tilt mode. The growth rate of the tilt instability is reduced by the kinetic effects. It is found that the stabilization effect of tilt mode becomes much distinct when the current density changes from the peaked profile to the hollow one. (author)

  12. Profile relaxation and tilt instability in a field-reversed configuration

    International Nuclear Information System (INIS)

    Ohtani, H.; Horiuchi, R.; Sato, T.

    2002-10-01

    The profile relaxation from a magnetohydrodynamic (MHD) profile to a kinetic equilibrium in field-reversed configurations (FRCs) is investigated by two-dimensional electromagnetic particle simulation. The radial oscillation takes place in order to relax an excess energy in the MHD profile, and the system spontaneously relaxes toward a kinetic equilibrium. In this kinetic equilibrium, the hollow electron current profile is realized as a result of the combined effects of the single particle orbits and the ion finite Larmor radius, and the ion current profile becomes peaked due to the effect of the ion meandering motion. Three-dimensional full electromagnetic particle simulation is also performed to study the stability of these kinetic equilibrium against the tilt mode. The growth rate of the tilt instability is reduced by the kinetic effects. It is found that the stabilization effect of tilt mode becomes much distinct when the current density changes from the peaked profile to the hollow one. (author)

  13. Profile relaxation and tilt instability in a field-reversed configuration

    International Nuclear Information System (INIS)

    Ohtani, H.; Horiuchi, R.; Sato, T.

    2002-01-01

    The profile relaxation from a magnetichydrodynamic (MHD) profile to a kinetic equilibrium in field-reversed configurations (FRCs) in investigated by two-dimensional electromagnetic particle simulation. The radial oscillation takes place in order to relax an excess energy in the MHD profile, and the system spontaneously relaxes toward a kinetic equilibrium. In this kinetic equilibrium, the hollow electron current profile is realized as a result of the combined effects of the single particle orbits and the ion finite Larmor radius, and the ion current profile becomes peaked due to the effect of the ion meandering motion. Three-dimensional full electromagnetic particle simulations is also performed to study the stability of these kinetic equilibrium against the tilt mode. The growth rate of the tilt instability is reduced by the kinetic is effects. It is found that the stabilization effect of tilt mode becomes much distinct when the current density changes from the peaked profile to the hollow one. (author)

  14. Principles concerning the promotion of the natural gas management in Romania

    International Nuclear Information System (INIS)

    Leca, Aureliu; Statie, Emil

    1996-01-01

    The consequences of the application of demand side management (DSM) and integrated resources planning (IRP) concepts for natural gas are analysed. Present socio-economic context in Romania - from a geopolitical point of view - highlights a set of gas supply problems in this country imposed by: the impossibility of satisfying the consumption demand from internal resources; the necessity of ensuring by imports of an important quantity of gas, which entails an important foreign currency expenditure and possible political pressures which an unique supplier could exert; the requirement of alignment to the European Union legislation at institutional and economical practice level. All of these problems related to the gas-based power production support the adopting of DSM and IRP concepts. Some conclusions and proposals are presented

  15. EVALUATION OF A NOVEL UAV-BORNE TOPO-BATHYMETRIC LASER PROFILER

    Directory of Open Access Journals (Sweden)

    G. Mandlburger

    2016-06-01

    Full Text Available We present a novel topo-bathymetric laser profiler. The sensor system (RIEGL BathyCopter comprises a laser range finder, an Inertial Measurement Unit (IMU, a Global Navigation Satellite System (GNSS receiver, a control unit, and digital cameras mounted on an octocopter UAV (RiCOPTER. The range finder operates on the time-of-flight measurement principle and utilizes very short laser pulses (<1 ns in the green domain of the spectrum (λ=532 nm for measuring distances to both the water surface and the river bottom. For assessing the precision and accuracy of the system an experiment was carried out in October 2015 at a pre-alpine river (Pielach in Lower Austria. A 200 m longitudinal section and 12 river cross sections were measured with the BathyCopter sensor system at a flight altitude of 15-20 m above ground level and a measurement rate of 4 kHz. The 3D laser profiler points were compared with independent, quasi-simultaneous data acquisitions using (i the RIEGL VUX1-UAV lightweight topographic laser scanning system (bare earth, water surface and (ii terrestrial survey (river bed. Over bare earth the laser profiler heights have a std. dev. of 3 cm, the water surface height appears to be underestimated by 5 cm, and river bottom heights differ from the reference measurements by 10 cm with a std. dev. of 13 cm. When restricting the comparison to laser profiler bottom points and reference measurements with a lateral offset below 1 m, the values improve to 4 cm bias with a std. dev. of 6 cm. We report additionally on challenges in comparing UAV-borne to terrestrial profiles. Based on the accuracy and the small footprint (3.5 cm at the water surface we concluded that the acquired 3D points can potentially serve as input data (river bed geometry, grain roughness and validation data (water surface, water depth for hydrodynamic-numerical models.

  16. Brief communication "Application of mobile laser scanning in snow cover profiling"

    Directory of Open Access Journals (Sweden)

    S. Kaasalainen

    2011-03-01

    Full Text Available We present a snowmobile-based mobile mapping system and its first application to snow cover roughness and change detection measurement. The ROAMER mobile mapping system, constructed at the Finnish Geodetic Institute, consists of the positioning and navigating systems, a terrestrial laser scanner, and the carrying platform (a snowmobile sledge in this application. We demonstrate the applicability of the instrument to snow cover roughness profiling and change detection by presenting preliminary results from a mobile laser scanning (MLS campaign. The results show the potential of MLS for fast and efficient snow profiling from large areas in a millimetre scale.

  17. Wire Scanner Beam Profile Measurements for the LANSCE Facility

    International Nuclear Information System (INIS)

    Gilpatrick, John D.; Gruchalla, Michael E.; Martinez, Derwin; Pillai, Chandra; Rodriguez Esparza, Sergio; Sedillo, James Daniel; Smith, Brian G.

    2012-01-01

    The Los Alamos Neutron Science Center (LANSCE) is replacing beam profile measurement systems, commonly known as Wire Scanners (WS). Using the principal of secondary electron emission, the WS measurement system moves a wire or fiber across an impinging particle beam, sampling a projected transverse-beam distribution. Because existing WS actuators and electronic components are either no longer manufactured or home-built with antiquated parts, a new WS beam profile measurement is being designed, fabricated, and tested. The goals for these new WS's include using off-the-shelf components while eliminating antiquated components, providing quick operation while allowing for easy maintainability, and tolerating external radioactivation. The WS measurement system consists of beam line actuators, a cable plant, an electronics processor chassis, and software located both in the electronics chassis (National Instruments LabVIEW) and in the Central Control Room (EPICS-based client software). This WS measurement system will measure Hand H + LANSCE-facility beams and will also measure less common beams. This paper describes these WS measurement systems.

  18. Use of professional profiles in applications for specialist training positions

    DEFF Research Database (Denmark)

    Lundh, Andreas; Skjelsager, Karen; Wildgaard, Kim

    2013-01-01

    INTRODUCTION: The seven roles of the CanMEDS system have been implemented in Danish postgraduate medical training. For each medical specialty, a professional profile describes which elements of the seven roles the specialty deems important for applicants for a specialist training position. We...... investigated use of professional profiles among the 38 Danish specialty societies in order to ascertain the use of the seven roles. MATERIAL AND METHODS: We used information from the websites of the Postgraduate Medical Training Secretariats in March 2012. For each profile, we extracted information on how...... the seven roles were described, how the roles were ranked by importance, whether a score sheet was used by the appointment committee and whether the profile had been updated. RESULTS: Twenty-four (63%) of the 38 profiles described the contents for all of the seven roles and four (11%) described the contents...

  19. Observation of asymmetric electromagnetic field profiles in chiral metamaterials

    Science.gov (United States)

    Hisamoto, Nobuyuki; Ueda, Tetsuya; Sawada, Kei; Tomita, Satoshi

    2018-02-01

    We experimentally observe asymmetric electromagnetic field profiles along two-dimensional chiral metamaterials. The asymmetric field profiles depending on the chirality and the operation frequency have been reproduced well by the numerical simulation. Around a chiral meta-atom, distribution of a Poynting vector is found to be shifted asymmetrically. These results are explained in terms of an analogy with the side-jump mechanism in the electronic anomalous Hall systems.

  20. An Andean-type retro-arc foreland system beneath northwest South China revealed by SINOPROBE profiling

    Science.gov (United States)

    Li, Jianhua; Dong, Shuwen; Cawood, Peter A.; Zhao, Guochun; Johnston, Stephen T.; Zhang, Yueqiao; Xin, Yujia

    2018-05-01

    In the Mesozoic, South China was situated along the convergent margin between the Asian and Pacific plates, providing an excellent laboratory to understand the interactions between deformation, sedimentation and magmatism in a retroarc environment. The crustal architecture of northwest South China is displayed along the ∼600-km-long SINOPROBE deep seismic reflection profiles and reveals from east to west: (1) highly folded and truncated reflectors in the upper crust of the Yangtze Fold Zone, which correspond to thin- and thick-skinned thrust systems, and document large-scale intraplate structural imbrication and shortening; (2) a crustal-scale flat-ramp-flat structure, termed the Main Yangtze decollement, which forms a weak, viscous layer to accommodate strain decoupling and material transport in the thin- and thick-skinned systems; and (3) nearly flat-lying reflectors in the Sichuan Basin, which support interpretation of the basin as a weakly deformed depocentre. The Yangtze Fold Zone and the Sichuan Basin represent a retro-arc foreland basin system that is >800 km away from the continental-margin magmatic arc. We suggest that tectonic processes across the arc and retro-arc systems, including arc magma flare-up, basin sedimentation, retroarc thrust propagation, lithosphere underthrusting, root foundering, and extension-related magmatism were interrelated and governed mass transfer. Age data and geological relations link the tectonic processes to evolving geodynamics of the subducting Paleo-Pacific plate.

  1. A design of speed reducer with trapezoidal tooth profile for robot manipulator

    Energy Technology Data Exchange (ETDEWEB)

    Nam, Won Ki; Oh, Se Hoon [Chung-Ang University, Seoul (Korea, Republic of)

    2011-01-15

    Robots are increasingly performing human work as manufacturing is automated. Accordingly, the use of precision speed reducers has become essential for achieving precise control of the robot arm position. Curved tooth profiles, such as cycloid or involute tooth profiles, are generally used in precision speed reducers. Speed reducers with cycloid tooth profiles, which enable high precision control, are widely used to manipulate robot systems. This study proposes a speed reducer that has a trapezoidal tooth profile with straight lines. In this work, we mechanically analyzed trapezoidal tooth profiles, and then measured performance was by various tests using a prototype manufactured specifically for this study.

  2. A design of speed reducer with trapezoidal tooth profile for robot manipulator

    International Nuclear Information System (INIS)

    Nam, Won Ki; Oh, Se Hoon

    2011-01-01

    Robots are increasingly performing human work as manufacturing is automated. Accordingly, the use of precision speed reducers has become essential for achieving precise control of the robot arm position. Curved tooth profiles, such as cycloid or involute tooth profiles, are generally used in precision speed reducers. Speed reducers with cycloid tooth profiles, which enable high precision control, are widely used to manipulate robot systems. This study proposes a speed reducer that has a trapezoidal tooth profile with straight lines. In this work, we mechanically analyzed trapezoidal tooth profiles, and then measured performance was by various tests using a prototype manufactured specifically for this study

  3. Determination of boundaries between ranges of high and low gradient of beam profile.

    Science.gov (United States)

    Wendykier, Jacek; Bieniasiewicz, Marcin; Grządziel, Aleksandra; Jedynak, Tadeusz; Kośniewski, Wiktor; Reudelsdorf, Marta; Wendykier, Piotr

    2016-01-01

    This work addresses the problem of treatment planning system commissioning by introducing a new method of determination of boundaries between high and low gradient in beam profile. The commissioning of a treatment planning system is a very important task in the radiation therapy. One of the main goals of this task is to compare two field profiles: measured and calculated. Applying points of 80% and 120% of nominal field size can lead to the incorrect determination of boundaries, especially for small field sizes. The method that is based on the beam profile gradient allows for proper assignment of boundaries between high and low gradient regions even for small fields. TRS 430 recommendations for commissioning were used. The described method allows a separation between high and low gradient, because it directly uses the value of the gradient of a profile. For small fields, the boundaries determined by the new method allow a commissioning of a treatment planning system according to the TRS 430, while the point of 80% of nominal field size is already in the high gradient region. The method of determining the boundaries by using the beam profile gradient can be extremely helpful during the commissioning of the treatment planning system for Intensity Modulated Radiation Therapy or for other techniques which require very small field sizes.

  4. The characterization of beam profile by modification of electrode shape

    International Nuclear Information System (INIS)

    Lee, Chan Young; Lee, Jae Sang

    2010-01-01

    Ion sources have been used for variety of industrial application over the past few decades and our research group has been studied about high current and large dimension ion source to meet the requirement from beam user. For a mass production in industry, a wide beam divergence and a beam profile of a broadly Gaussian shape is very needed. Generally, the production process like roll-to-roll or in-line system is need one-meter in diameter, ±5% in uniformity. Therefore it is difficult to apply with present system like 0.3-meter in diameter, ±20% in uniformity and needed new type ion source. In this study, it is approached with modification of electrode grid shape without fabrication of new type ion source. We modified from parallel type to hemispherical type electrode grid to secure large dimension ion beam and were discussed with respect to beam profile calculated with IGUN code simulation. Also, we identified beam profile before and after modification of electrode grid system(cathode, Acelldecel grid) with measurement of faraday cup

  5. Profile parameters of wheelset detection for high speed freight train

    Science.gov (United States)

    Yang, Kai; Ma, Li; Gao, Xiaorong; Wang, Li

    2012-04-01

    Because of freight train, in China, transports goods on railway freight line throughout the country, it does not depart from or return to engine shed during a long phase, thus we cannot monitor the quality of wheel set effectively. This paper provides a system which uses leaser and high speed camera, applies no-contact light section technology to get precise wheel set profile parameters. The paper employs clamping-track method to avoid complex railway ballast modification project. And detailed descript an improved image-tracking algorithm to extract central line from profile curve. For getting one pixel width and continuous line of the profile curve, uses local gray maximum points as direction control points to direct tracking direction. The results based on practical experiment show the system adapted to detection environment of high speed and high vibration, and it can effectively detect the wheelset geometric parameters with high accuracy. The system fills the gaps in wheel set detection for freight train in main line and has an enlightening function on monitoring the quality of wheel set.

  6. CRISPR-cas loci profiling of Cronobacter sakazakii pathovars.

    Science.gov (United States)

    Ogrodzki, Pauline; Forsythe, Stephen James

    2016-12-01

    Cronobacter sakazakii sequence types 1, 4, 8 and 12 are associated with outbreaks of neonatal meningitis and necrotizing enterocolitis infections. However clonality results in strains which are indistinguishable using conventional methods. This study investigated the use of clustered regularly interspaced short palindromic repeats (CRISPR)-cas loci profiling for epidemiological investigations. Seventy whole genomes of C. sakazakii strains from four clonal complexes which were widely distributed temporally, geographically and origin of source were profiled. All strains encoded the same type I-E subtype CRISPR-cas system with a total of 12 different CRISPR spacer arrays. This study demonstrated the greater discriminatory power of CRISPR spacer array profiling compared with multilocus sequence typing, which will be of use in source attribution during Cronobacter outbreak investigations.

  7. Raman lidar water vapor profiling over Warsaw, Poland

    Science.gov (United States)

    Stachlewska, Iwona S.; Costa-Surós, Montserrat; Althausen, Dietrich

    2017-09-01

    Water vapor mixing ratio and relative humidity profiles were derived from the multi-wavelength Raman PollyXT lidar at the EARLINET site in Warsaw, using the Rayleigh molecular extinction calculation based on atmospheric temperature and pressure from three different sources: i) the standard atmosphere US 62, ii) the Global Data Assimilation System (GDAS) model output, and iii) the WMO 12374 radiosoundings launched at Legionowo. With each method, 136 midnight relative humidity profiles were obtained for lidar observations from July 2013 to August 2015. Comparisons of these profiles showed in favor of the latter method (iii), but it also indicated that the other two data sources could replace it, if necessary. Such use was demonstrated for an automated retrieval of water vapor mixing ratio from dusk until dawn on 19/20 March 2015; a case study related to an advection of biomass burning aerosol from forest fires over Ukraine. Additionally, an algorithm that applies thresholds to the radiosounding relative humidity profiles to estimate macro-physical cloud vertical structure was used for the first time on the Raman lidar relative humidity profiles. The results, based on a subset of 66 profiles, indicate that below 6 km cloud bases/tops can be successfully obtained in 53% and 76% cases from lidar and radiosounding profiles, respectively. Finally, a contribution of the lidar derived mean relative humidity to cloudy conditions within the range of 0.8 to 6.2 km, in comparison to clear-sky conditions, was estimated.

  8. Fitting the IRI F2-profile function to measured profiles

    International Nuclear Information System (INIS)

    Reinisch, B.W.; Huang Xueqin

    1997-01-01

    Comparison with profile data from ionosondes shows that the IRI bottomside F2-profiles can be improved by using better B0 and B1 parameters. The best parameters (in a least-squares sense) can be easily calculated in a numerical procedure from measured profiles presented as a sum of Chebyshev polynomials. 7 refs, 5 figs, 1 tab

  9. Effect of high intensity ultrasound on the fermentation profile of Lactobacillus sakei in a meat model system.

    Science.gov (United States)

    Ojha, Kumari Shikha; Kerry, Joseph P; Alvarez, Carlos; Walsh, Des; Tiwari, Brijesh K

    2016-07-01

    The objective of this study was to investigate the efficacy of high intensity ultrasound on the fermentation profile of Lactobacillus sakei in a meat model system. Ultrasound power level (0-68.5 W) and sonication time (0-9 min) at 20 °C were assessed against the growth of L. sakei using a Microplate reader over a period of 24h. The L. sakei growth data showed a good fit with the Gompertz model (R(2)>0.90; SEfunctional food products can be tailored by selection of ultrasound processing parameters. Copyright © 2016 Elsevier B.V. All rights reserved.

  10. The evaluator’s profile in certifying professional competences: a new educational role

    Directory of Open Access Journals (Sweden)

    Arcadia Martín Pérez

    2009-04-01

    Full Text Available The Accreditation, Evaluation and Recognition Systems are intended at certifying professional competences associated to a specific professional profile acquired through any kind of learning (formal, non-formal and informal. The key element in this system is the process of evaluation which leads to verify such competences. In this paper we focus on the professional profile of the evaluator in the accreditation, evaluation and recognition systems, highlighting the development of a new line of professional development for teachers and trainers in formal and non-formal education.

  11. Machine Vision for Object Detection and Profiling in an Unstructured Environment

    Energy Technology Data Exchange (ETDEWEB)

    Walton, Miles Conley; Kinoshita, Robert Arthur

    2002-08-01

    The Handling and Sorting System for 55-Gallon Drums (HANDSS-55) is a DOE project to develop an automated method for retrieving items that are not acceptable at the Waste Isolation Pilot Plant (WIPP) from 55-gallon drums of low-level waste. The HANDSS-55 is a modular system that opens drums, sorts the waste, and then repackages the remaining waste in WIPP compliant barrels. The Sorting Station module relies on a non-contact measurement system to quickly provide a 3D profile of the sorting area. It then analyses the 3D profile and a color image to determine the position and orientation of an operator selected waste item. The item is then removed from the sorting area by a robotic arm. The use of both image and profile information for object determination provides a fast, effective method of finding and retrieving selected objects in the unstructured environment of the sorting module.

  12. Machine Vision for Object Detection and Profiling in an Unstructured Environment

    Energy Technology Data Exchange (ETDEWEB)

    Kinoshita, R.A.; Walton, M.C.

    2002-05-23

    The Handling and Sorting System for 55-Gallon Drums (HANDSS-55) is a DOE project to develop an automated method for retrieving items that are not acceptable at the Waste Isolation Pilot Plant (WIPP) from 55-gallon drums of low-level waste. The HANDSS-55 is a modular system that opens drums, sorts the waste, and then repackages the remaining waste in WIPP compliant barrels. The Sorting Station module relies on a non-contact measurement system to quickly provide a 3D profile of the sorting area. It then analyses the 3D profile and a color image to determine the position and orientation of an operator selected waste item. The item is then removed from the sorting area by a robotic arm. The use of both image and profile information for object determination provides a fast, effective method of finding and retrieving selected objects in the unstructured environment of the sorting module.

  13. Machine Vision for Object Detection and Profiling in an Unstructured Environment

    International Nuclear Information System (INIS)

    Kinoshita, R.A.; Walton, M.C.

    2002-01-01

    The Handling and Sorting System for 55-Gallon Drums (HANDSS-55) is a DOE project to develop an automated method for retrieving items that are not acceptable at the Waste Isolation Pilot Plant (WIPP) from 55-gallon drums of low-level waste. The HANDSS-55 is a modular system that opens drums, sorts the waste, and then repackages the remaining waste in WIPP compliant barrels. The Sorting Station module relies on a non-contact measurement system to quickly provide a 3D profile of the sorting area. It then analyses the 3D profile and a color image to determine the position and orientation of an operator selected waste item. The item is then removed from the sorting area by a robotic arm. The use of both image and profile information for object determination provides a fast, effective method of finding and retrieving selected objects in the unstructured environment of the sorting module

  14. 7 CFR 4274.381 - Exception authority.

    Science.gov (United States)

    2010-01-01

    ... Program (IRP) § 4274.381 Exception authority. The Administrator may, in individual cases, grant an exception to any requirement or provision of this subpart which is not inconsistent with any applicable law...

  15. 2010 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    None

    2010-01-01

    This annual report includes: an overview of Western; approaches for future hydropower and transmission service; major achievements in FY 2010; FY 2010 customer Integrated Resource Planning, or IRP, survey; and financial data.

  16. Identification and real time control of current profile in Tore-supra: algorithms and simulation; Identification et controle en temps reel du profil de courant dans Tore Supra: algorithmes et simulations

    Energy Technology Data Exchange (ETDEWEB)

    Houy, P

    1999-10-15

    The aim of this work is to propose a real-time control of the current profile in order to achieve reproducible operating modes with improved energetic confinement in tokamaks. The determination of the profile is based on measurements given by interferometry and polarimetry diagnostics. Different ways to evaluate and improve the accuracy of these measurements are exposed. The position and the shape of a plasma are controlled by the poloidal system that forces them to cope with standard values. Gas or neutral ions or ice pellet or extra power injection are technical means used to control other plasma parameters. These controls are performed by servo-controlled loops. The poloidal system of Tore-supra is presented. The main obstacle to a reliable determination of the current profile is the fact that slightly different Faraday angles lead to very different profiles. The direct identification method that is exposed in this work, gives the profile that minimizes the square of the margin between measured and computed values. The different algorithms proposed to control current profiles on Tore-supra have been validated by using a plasma simulation. The code Cronos that solves the resistive diffusion equation of current has been used. (A.C.)

  17. Large-scale integration of small molecule-induced genome-wide transcriptional responses, Kinome-wide binding affinities and cell-growth inhibition profiles reveal global trends characterizing systems-level drug action

    Directory of Open Access Journals (Sweden)

    Dusica eVidovic

    2014-09-01

    Full Text Available The Library of Integrated Network-based Cellular Signatures (LINCS project is a large-scale coordinated effort to build a comprehensive systems biology reference resource. The goals of the program include the generation of a very large multidimensional data matrix and informatics and computational tools to integrate, analyze, and make the data readily accessible. LINCS data include genome-wide transcriptional signatures, biochemical protein binding profiles, cellular phenotypic response profiles and various other datasets for a wide range of cell model systems and molecular and genetic perturbations. Here we present a partial survey of this data facilitated by data standards and in particular a robust compound standardization workflow; we integrated several types of LINCS signatures and analyzed the results with a focus on mechanism of action and chemical compounds. We illustrate how kinase targets can be related to disease models and relevant drugs. We identified some fundamental trends that appear to link Kinome binding profiles and transcriptional signatures to chemical information and biochemical binding profiles to transcriptional responses independent of chemical similarity. To fill gaps in the datasets we developed and applied predictive models. The results can be interpreted at the systems level as demonstrated based on a large number of signaling pathways. We can identify clear global relationships, suggesting robustness of cellular responses to chemical perturbation. Overall, the results suggest that chemical similarity is a useful measure at the systems level, which would support phenotypic drug optimization efforts. With this study we demonstrate the potential of such integrated analysis approaches and suggest prioritizing further experiments to fill the gaps in the current data.

  18. High-resolution humidity profiles retrieved from wind profiler radar measurements

    Science.gov (United States)

    Saïd, Frédérique; Campistron, Bernard; Di Girolamo, Paolo

    2018-03-01

    The retrieval of humidity profiles from wind profiler radars has already been documented in the past 30 years and is known to be neither as straightforward and nor as robust as the retrieval of the wind velocity. The main constraint to retrieve the humidity profile is the necessity to combine measurements from the wind profiler and additional measurements (such as observations from radiosoundings at a coarser time resolution). Furthermore, the method relies on some assumptions and simplifications that restrict the scope of its application. The first objective of this paper is to identify the obstacles and limitations and solve them, or at least define the field of applicability. To improve the method, we propose using the radar capacity to detect transition levels, such as the top level of the boundary layer, marked by a maximum in the radar reflectivity. This forces the humidity profile from the free troposphere and from the boundary layer to coincide at this level, after an optimization of the calibration coefficients, and reduces the error. The resulting mean bias affecting the specific humidity profile never exceeds 0.25 g kg-1. The second objective is to explore the capability of the algorithm to retrieve the humidity vertical profiles for an operational purpose by comparing the results with observations from a Raman lidar.

  19. Profiling Systems Using the Defining Characteristics of Systems of Systems (SoS)

    Science.gov (United States)

    2010-02-01

    system exhaust and emissions system gas engine heating and air conditioning system fuel system regenerative braking system safety system...overcome the limitations of these fuzzy scales, measurement scales are often divided into a relatively small number of disjoint categories so that the...precision is not justified. This lack of precision can typically be addressed by breaking the measurement scale into a set of categories , the use of

  20. Floquet states of a kicked particle in a singular potential: Exponential and power-law profiles

    Science.gov (United States)

    Paul, Sanku; Santhanam, M. S.

    2018-03-01

    It is well known that, in the chaotic regime, all the Floquet states of kicked rotor system display an exponential profile resulting from dynamical localization. If the kicked rotor is placed in an additional stationary infinite potential well, its Floquet states display power-law profile. It has also been suggested in general that the Floquet states of periodically kicked systems with singularities in the potential would have power-law profile. In this work, we study the Floquet states of a kicked particle in finite potential barrier. By varying the height of finite potential barrier, the nature of transition in the Floquet state from exponential to power-law decay profile is studied. We map this system to a tight-binding model and show that the nature of decay profile depends on energy band spanned by the Floquet states (in unperturbed basis) relative to the potential height. This property can also be inferred from the statistics of Floquet eigenvalues and eigenvectors. This leads to an unusual scenario in which the level spacing distribution, as a window in to the spectral correlations, is not a unique characteristic for the entire system.

  1. Residual lower esophageal sphincter pressure as a prognostic factor in the pneumatic balloon treatment of achalasia.

    Science.gov (United States)

    Park, Jung Ho; Lee, Yong Chan; Lee, Hyuk; Park, Hyojin; Youn, Young Hoon; Park, Hyung Seok; Lee, Tae Hee; Hong, Kyoung Sup

    2015-01-01

    Pneumatic balloon dilatation (PD) is a mainstay in achalasia treatment. The aim of this study was to identify predictive factors for successful treatment. We retrospectively reviewed 76 patients with a diagnosis of achalasia who underwent PD from June 2010 to May 2013. Clinical symptoms were assessed using Eckardt score and manometry data were analyzed using resting and relaxation pressure (4sIRP) of lower esophageal sphincter (LES) and the distal contractile integral (DCI), which was calculated for 10 s from the start of deglutition between the upper margin of the LES and lower margin of upper esophageal contraction. Patients with achalasia were classified into three groups based on the Chicago classification. Among 76 patients, 52 patients received PD, and the treatment was unsuccessful in 9 patients (6 in class I and 3 in class III). When comparing prognostic factors between successful and unsuccessful treatment groups, the mean value for 4sIRP in the unsuccessful treatment group was significantly lower than that in the successful treatment group (P treatment of achalasia (odds ratio, 1.092; 95% confidence interval, 1.001-1.191) even after adjustment for a series of confounding factors. Lower 4sIRP may be a prognostic indicator for poor treatment outcome after PD. © 2014 Journal of Gastroenterology and Hepatology Foundation and Wiley Publishing Asia Pty Ltd.

  2. Management of idiopathic recurrent pericarditis in adults and in children: a role for IL-1 receptor antagonism.

    Science.gov (United States)

    Brucato, Antonio; Emmi, Giacomo; Cantarini, Luca; Di Lenarda, Andrea; Gattorno, Marco; Lopalco, Giuseppe; Marcolongo, Renzo; Imazio, Massimo; Martini, Alberto; Prisco, Domenico

    2018-06-01

    Recurrent pericarditis is one of the most frequent pericardial diseases, affecting up to 30% of the patients who have experienced acute pericarditis. While the diagnosis of acute pericarditis is sometime straight forward, its etiology and therapeutic management are still a challenge for physicians. In developed countries, the idiopathic form is the most frequent, and the search for an infectious etiology is almost invariably negative. Nevertheless, since standard treatment with nonsteroidal anti-inflammatory drugs and colchicine is not always able to neutralize pericardial inflammation in recurrent pericarditis, anakinra, an IL-1 receptor antagonist, has been proposed as a possible therapeutic alternative for refractory forms. IL-1 is a cytokine that exerts a pivotal role in innate immunity and in the pathogenesis of some autoimmune diseases, such as rheumatoid arthritis, and in autoinflammatory disorders, as familial Mediterranean fever and cryopyrin-associated periodic syndromes. The successful management of patients with acute idiopathic recurrent pericarditis (IRP) needs a teamwork approach, where cardiologists, rheumatologists, clinical immunologists and internists are involved. In this review, we will discuss the clinical and therapeutical challenges of IRP both in adults and children from a clinical practice standpoint. We will also briefly illustrate the main pathogenic mechanisms of IRP to provide internists and cardiologists with the rationale for approaching the use of anakinra in selected clinical cases.

  3. Aspirin down Regulates Hepcidin by Inhibiting NF-κB and IL6/JAK2/STAT3 Pathways in BV-2 Microglial Cells Treated with Lipopolysaccharide

    Directory of Open Access Journals (Sweden)

    Wan-Ying Li

    2016-12-01

    Full Text Available Aspirin down regulates transferrin receptor 1 (TfR1 and up regulates ferroportin 1 (Fpn1 and ferritin expression in BV-2 microglial cells treated without lipopolysaccharides (LPS, as well as down regulates hepcidin and interleukin 6 (IL-6 in cells treated with LPS. However, the relevant mechanisms are unknown. Here, we investigate the effects of aspirin on expression of hepcidin and iron regulatory protein 1 (IRP1, phosphorylation of Janus kinase 2 (JAK2, signal transducer and activator of transcription 3 (STAT3 and P65 (nuclear factor-κB, and the production of nitric oxide (NO in BV-2 microglial cells treated with and without LPS. We demonstrated that aspirin inhibited hepcidin mRNA as well as NO production in cells treated with LPS, but not in cells without LPS, suppresses IL-6, JAK2, STAT3, and P65 (nuclear factor-κB phosphorylation and has no effect on IRP1 in cells treated with or without LPS. These findings provide evidence that aspirin down regulates hepcidin by inhibiting IL6/JAK2/STAT3 and P65 (nuclear factor-κB pathways in the cells under inflammatory conditions, and imply that an aspirin-induced reduction in TfR1 and an increase in ferritin are not associated with IRP1 and NO.

  4. Effect of tooth profile modification on wear in internal gears

    Science.gov (United States)

    Tunalioglu, M. S.; Tuc, B.

    2018-05-01

    Internal gears are often used in the automotive industry when two gears are required to rotate in the same direction. Tooth shapes, slippage speeds at the beginning and end of meshing are different according to the external gears. Manufacturing of internal gears is more difficult than external gears. Thus, it is necessary to determine the working conditions and wear behavior of internal gears carefully. The profile modification method in terms of strength and surface tension of the gear mechanism are performed in order to increase the load-carrying capability. In this study, profile modification method was performed in the internal gears to reduce the wear on the teeth. For this purpose, the wear of the internal gears was theoretically investigated by adapting the Archard wear equation to the internal gears. Closed circuit power circulation system was designed and manufactured to experimentally investigate the wear in internal gears. With this system, wear tests of gears made of St 50 material without profile modification and different profile modifications were made and the results were compared. Experimental study was performed in the same loading and cycle time conditions to validate the theoretical results and it was seen that the results are compatible. According to the experimental results, it is seen that in the internal gears, when profile modification done the wear is decreased in the teeth tip region.

  5. Validation of the FSA nutrient profiling system dietary index in French adults-findings from SUVIMAX study.

    Science.gov (United States)

    Julia, Chantal; Méjean, Caroline; Touvier, Mathilde; Péneau, Sandrine; Lassale, Camille; Ducrot, Pauline; Hercberg, Serge; Kesse-Guyot, Emmanuelle

    2016-08-01

    Population-wide nutritional recommendations give guidance on food groups' consumption, though a wide variability in nutritional quality within groups may subsist. Nutrient profiling systems may help capturing such variability. We aimed to apply and validate a dietary index based on the British Food Standards Agency nutrient profiling system (FSA-NPS DI) in French middle-aged adults. Dietary data were collected through repeated 24-h dietary records in participants of the Supplémentation en Vitamines et Minéraux Antioxydants study (N = 5882). An aggregated dietary index at the individual level was computed using the FSA-NPS for each food consumed as well as compliance to the French nutritional guidelines using the Programme National Nutrition Santé-Guideline Score (PNNS-GS). Cross-sectional associations between FSA-NPS DI and nutrient intake, PNNS-GS, socio-demographic factors, lifestyle and nutritional biomarkers were computed using ANOVAs. The FSA-NPS DI was able to characterize the quality of the diets at the individual level in terms of nutrient intake and of adherence to nutritional recommendations: +37.6 % in beta-carotene intakes between subjects with a healthier diet versus subjects with a poorer diet, +42.8 % in vitamin C intakes; +17 % in PNNS-GS, all P < 0.001. FSA-NPS-DI was also associated with nutritional status at the biological level: +21.4 % in beta-carotene levels between subjects with a healthier diet versus subjects with a poorer diet, +12.8 % in vitamin C levels, all P < 0.001. The FSA-NPS DI is a useful and validated tool to discriminate individuals according to the quality of the diet, accounting for nutritional quality within food groups. Taking into account nutritional quality of individual foods allows monitoring change in dietary patterns beyond food groups.

  6. Estimation and display of beam density profiles

    Energy Technology Data Exchange (ETDEWEB)

    Dasgupta, S; Mukhopadhyay, T; Roy, A; Mallik, C

    1989-03-15

    A setup in which wire-scanner-type beam-profile monitor data are collected on-line in a nuclear data-acquisition system has been used and a simple algorithm for estimation and display of the current density distribution in a particle beam is described.

  7. Quality-Controlled Wind Data from the Kennedy Space Center 915 Megahertz Doppler Radar Wind Profiler Network

    Science.gov (United States)

    Dryden, Rachel L.

    2011-01-01

    The National Aeronautics and Space Administration s (NASA) Kennedy Space Center (KSC) has installed a five-instrument 915-Megahertz (MHz) Doppler Radar Wind Profiler (DRWP) system that records atmospheric wind profile properties. The purpose of these profilers is to fill data gaps between the top of the KSC wind tower network and the lowest measurement altitude of the KSC 50-MHz DRWP. The 915-MHz DRWP system has the capability to generate three-dimensional wind data outputs from approximately 150 meters (m) to 6,000 m at roughly 15-minute (min) intervals. NASA s long-term objective is to combine the 915-MHz and 50-MHz DRWP systems to create complete vertical wind profiles up to 18,300 m to be used in trajectory and loads analyses of space vehicles and by forecasters on day-of-launch (DOL). This analysis utilizes automated and manual quality control (QC) processes to remove erroneous and unrealistic wind data returned by the 915-MHz DRWP system. The percentage of data affected by each individual QC check in the period of record (POR) (i.e., January to April 2006) was computed, demonstrating the variability in the amount of data affected by the QC processes. The number of complete wind profiles available at given altitude thresholds for each profiler in the POR was calculated and outputted graphically, followed by an assessment of the number of complete wind profiles available for any profiler in the POR. A case study is also provided to demonstrate the QC process on a day of a known weather event.

  8. Current profile reconstruction using electron temperature imaging diagnostics

    International Nuclear Information System (INIS)

    Tritz, K.; Stutman, D.; Delgado-Aparicio, L.F.; Finkenthal, M.; Pacella, D.; Kaita, R.; Stratton, B.; Sabbagh, S.

    2004-01-01

    Flux surface shape information can be used to constrain the current profile for reconstruction of the plasma equilibrium. One method of inferring flux surface shape relies on plasma x-ray emission; however, deviations from the flux surfaces due to impurity and density asymmetries complicate the interpretation. Electron isotherm surfaces should correspond well to the plasma flux surfaces, and equilibrium constraint modeling using this isotherm information constrains the current profile. The KFIT code is used to assess the profile uncertainty and to optimize the number, location and SNR required for the Te detectors. As Te imaging detectors we consider tangentially viewing, vertically spaced, linear gas electron multiplier arrays operated in pulse height analysis (PHA) mode and multifoil soft x-ray arrays. Isoflux coordinate sets provided by T e measurements offer a strong constraint on the equilibrium reconstruction in both a stacked horizontal array configuration and a crossed horizontal and vertical beam system, with q 0 determined to within ±4%. The required SNR can be provided with either PHA or multicolor diagnostic techniques, though the multicolor system requires ∼x4 better statistics for comparable final errors

  9. A 1290 MHZ profiler with RASS for monitoring wind and temperature in the boundary layer

    Energy Technology Data Exchange (ETDEWEB)

    Engelbart, D. [Deutscher Wetterdienst, Lindenberg (Germany). Meteorol. Obs.; Steinhagen, H. [Deutscher Wetterdienst, Lindenberg (Germany). Meteorol. Obs.; Goersdorf, U. [Deutscher Wetterdienst, Lindenberg (Germany). Meteorol. Obs.; Lippmann, J. [Deutscher Wetterdienst, Lindenberg (Germany). Meteorol. Obs.; Neisser, J. [Deutscher Wetterdienst, Lindenberg (Germany). Meteorol. Obs.

    1996-02-01

    A boundary layer wind profiler with RASS is described operating at 1290 MHz in a quasi-operational mode at the Meteorological Observatory Lindenberg of the German Weather Service (DWD). It provides vertical profiles of wind and temperature from the lower atmosphere with a height resolution of 50 m to 400 m and a time resolution of about 1 to 60 minutes. For an estimation of the system reliability, the availability of the measurements for all different height levels is analyzed. With regard to the data quality, a comparison of wind profiler/RASS and rawinsonde data is presented based on 856 wind and 451 temperature profiles. It reveals reasonable conformity of both sounding systems. Finally, case studies are shown, demonstrating the system ability to analyze some characteristic phenomena in the lower troposphere, which are unresolved temporally and spatially by the routine rawinsonde network. (orig.)

  10. Exploring the relationship between planning and procurement in Western U.S. electric utilities

    Energy Technology Data Exchange (ETDEWEB)

    Carvallo Bodelon, Juan Pablo [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Energy Analysis and Environmental Impacts Division; Sanstad, Alan H. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Energy Analysis and Environmental Impacts Division; Larsen, Peter H. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Energy Analysis and Environmental Impacts Division

    2017-06-01

    Integrated resource planning (IRP) is an important regulatory process used in many U.S. states to formulate and evaluate least-cost and risk-assessed portfolios to meet future load requirements for electric utilities. In principle, effective implementation of IRP seeks to assure regulators and the public that utility investment decisions, given uncertainty, are as cost-effective as possible. However, to date, there is no empirical assessment on the effectiveness of IRP implementation. In this analysis, we compare planning, procurement processes and actual decisions for a sample of twelve load serving entities (LSEs) across the Western U. S. from 2003-2014. The 2008/2009 recession provides a unique “stress test” to the planning process and offers an excellent opportunity to trace how procurement decisions responded to this largely unforeseen event. In aggregate, there is a general alignment between planned and procured supply-side capacity. However, there are significant differences in the choice of supply-side resources and type of ownership for individual LSEs. We develop case studies for three LSEs and find that subsequent plans differ significantly due to changes in the planning environment and that procurement decisions in some cases are impacted by factors that are not accounted for in the planning process. Our results reveal that a limited amount of information produced during the long-term planning process (e.g., forecasts, methods, and least cost/risk portfolios) are ultimately used during the procurement process, and that the latter process relies extensively on the most recent information available for decision making. These findings suggest that states' IRP rules and regulations mandating long-term planning horizons with the same analytical complexity throughout the planning period may not create useful information for the procurement process. The social value of a long-term planning process that departs from procurement and the balance between

  11. Transmission congestion and voltage profile management coordination in competitive electricity markets

    International Nuclear Information System (INIS)

    Yamin, H.Y.; Shahidehpour, S.M.

    2003-01-01

    This paper describes a generalized active/reactive iterative coordination process between GENCOs and the Independent System Operator (ISO) for active (transmission congestion) and reactive (voltage profile) management in the day-ahead market. GENCOs apply priced-based unit commitment without transmission and voltage security constraints, schedule their units and submit their initial bids to the ISO. The ISO executes congestion and voltage profile management for eliminating transmission and voltage profile violations. If violations are not eliminated, the ISO minimizes the transmission and voltage profile violations and sends a signal via the Internet to GENCOs. GENCOs reschedule their units taking into account the ISO signals and submit modified bids to the ISO. The voltage problem is addressed and a linear model is formulated and used in the proposed method. The voltage problem is formulated as a linear programming with a block-angular structure and Dantzig-Wolfe decomposition is applied to generate several smaller problems for a faster and easier solution of large-scale power systems. Two 36 unit GENCOs are used to demonstrate the performance of the proposed generalized active/reactive coordination algorithm. (author)

  12. Criminal Justice Profile--Statewide, 1984. Supplement to "Crime and Delinquency in California."

    Science.gov (United States)

    California State Dept. of Justice, Sacramento. Bureau of Criminal Statistics and Special Services.

    This California annual Criminal Justice Statewide Profile presents data which supplements the Bureau of Criminal Statistics' (BCS) annual Crime and Delinquency publication. This monograph summarizes and combines data pertaining to California's justice system. The profile consists of two sections. The first section consists of 12 tables displaying…

  13. Cross Racial Identity Scale (CRIS) scores and profiles in African American adolescents involved with the juvenile justice system.

    Science.gov (United States)

    Worrell, Frank C; Andretta, James R; Woodland, Malcolm H

    2014-10-01

    In this study, we examined the internal consistency and structural validity of Cross Racial Identity Scale (CRIS) scores in a sample of 477 African American adolescents who had been arrested in a city in the mid-Atlantic. Using cluster analysis, we also identified profiles of CRIS scores and compared adolescents with different profiles on Major Depressive Episode, Manic Episode, Generalized Anxiety Disorder, and Obsessive-Compulsive Disorder scores. Results indicated that CRIS subscale scores were reliable, and the 6-factor structure of the CRIS was supported. Five nigrescence profiles were identified: Miseducation-Pro-Black, Conflicted-Self-Hatred, Multiculturalist, Low Race Salience, and Conflicted-Anti-White. Individuals with Conflicted-Self-Hatred profiles reported significantly and meaningfully higher scores on the 4 syndromes than did their peers, and individuals with the Multiculturalist and Low Race Salience profiles reported the lowest scores. A greater percentage of individuals with Conflicted racial identity profiles had syndrome scores in the clinically significant range. The results of this study demonstrate that some of the nigrescence profiles found in college-age students generalize to adolescents. The implications of the findings for theory, research, and practice are discussed. PsycINFO Database Record (c) 2014 APA, all rights reserved.

  14. Retrieval method of aerosol extinction coefficient profile by an integral lidar system and case study

    Science.gov (United States)

    Shan, Huihui; Zhang, Hui; Liu, Junjian; Wang, Shenhao; Ma, Xiaomin; Zhang, Lianqing; Liu, Dong; Xie, Chenbo; Tao, Zongming

    2018-02-01

    Aerosol extinction coefficient profile is an essential parameter for atmospheric radiation model. But it is difficult to get the full aerosol extinction profile from the ground to the tropopause especially in near ground precisely using backscattering lidar. A combined measurement of side-scattering, backscattering and Raman-scattering lidar is proposed to retrieve the aerosol extinction coefficient profile from the surface to the tropopause which covered a dynamic range of 5 orders. The side-scattering technique solves the dead zone and the overlap problem caused by the traditional lidar in the near range. Using the Raman-scattering the aerosol lidar ratio (extinction to backscatter ratio) can be obtained. The cases studies in this paper show the proposed method is reasonable and feasible.

  15. ORIGINAL ARTICLES Changing gender profile of medical schools ...

    African Journals Online (AJOL)

    2008-06-23

    Jun 23, 2008 ... Changing gender profile of medical schools in South Africa. Mignonne ... The Higher Education Management Information System. (HEMIS) ..... specialty and gender: A study of teachers at a Swedish medical school. BMC Med ...

  16. UGV Control Interoperability Profile (IOP), Version 0

    Science.gov (United States)

    2011-12-21

    a tracked vehicle to climb stairs , traverse ditches/ruts, etc. The operator should be able to control the position of the flippers via the OCU and...Unclassified UGV Control Interoperability Profile (IOP) Version 0 Robotic Systems, Joint Project Office (RS JPO) SFAE-GCS-UGV MS...NUMBER 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Robotic Systems, Joint Project Office (RS JPO),SFAE-GCS-UGV MS 266,6501 East 11 Mile Road

  17. YOUNG ATHLETES' MOTIVATIONAL PROFILES

    Directory of Open Access Journals (Sweden)

    Juan Antonio Moreno Murcia

    2007-06-01

    Full Text Available The aim of this study was to examine the relationship between motivational characteristics and dispositional flow. In order to accomplish this goal, motivational profiles emerging from key constructs within Achievement Goal Theory and Self-Determination Theory were related to the dispositional flow measures. A sample of 413 young athletes (Age range 12 to 16 years completed the PMCSQ-2, POSQ, SMS and DFS measures. Cluster analysis results revealed three profiles: a "self-determined profile" characterised by higher scores on the task-involving climate perception and on the task orientation; a "non-self-determined profile", characterised by higher scores on ego-involving climate perception and ego orientation; and a "low self-determined and low non-self-determined profile" which had the lowest dispositional flow. No meaningful differences were found between the "self-determined profile" and the "non-self-determined profile" in dispositional flow. The "self-determined profile" was more commonly associated with females, athletes practising individual sports and those training more than three days a week. The "non-self-determined profile" was more customary of males and athletes practising team sports as well as those training just two or three days a week

  18. Controlled meteorological (CMET free balloon profiling of the Arctic atmospheric boundary layer around Spitsbergen compared to ERA-Interim and Arctic System Reanalyses

    Directory of Open Access Journals (Sweden)

    T. J. Roberts

    2016-09-01

    Full Text Available Observations from CMET (Controlled Meteorological balloons are analysed to provide insights into tropospheric meteorological conditions (temperature, humidity, wind around Svalbard, European High Arctic. Five Controlled Meteorological (CMET balloons were launched from Ny-Ålesund in Svalbard (Spitsbergen over 5–12 May 2011 and measured vertical atmospheric profiles over coastal areas to both the east and west. One notable CMET flight achieved a suite of 18 continuous soundings that probed the Arctic marine boundary layer (ABL over a period of more than 10 h. Profiles from two CMET flights are compared to model output from ECMWF Era-Interim reanalysis (ERA-I and to a high-resolution (15 km Arctic System Reanalysis (ASR product. To the east of Svalbard over sea ice, the CMET observed a stable ABL profile with a temperature inversion that was reproduced by ASR but not captured by ERA-I. In a coastal ice-free region to the west of Svalbard, the CMET observed a stable ABL with strong wind shear. The CMET profiles document increases in ABL temperature and humidity that are broadly reproduced by both ASR and ERA-I. The ASR finds a more stably stratified ABL than observed but captured the wind shear in contrast to ERA-I. Detailed analysis of the coastal CMET-automated soundings identifies small-scale temperature and humidity variations with a low-level flow and provides an estimate of local wind fields. We demonstrate that CMET balloons are a valuable approach for profiling the free atmosphere and boundary layer in remote regions such as the Arctic, where few other in situ observations are available for model validation.

  19. SURFACE BRIGHTNESS PROFILES OF DWARF GALAXIES. I. PROFILES AND STATISTICS

    International Nuclear Information System (INIS)

    Herrmann, Kimberly A.; Hunter, Deidre A.; Elmegreen, Bruce G.

    2013-01-01

    Radial surface brightness profiles of spiral galaxies are classified into three types: (I) single exponential, or the light falls off with one exponential to a break before falling off (II) more steeply, or (III) less steeply. Profile breaks are also found in dwarf disks, but some dwarf Type IIs are flat or increasing out to a break before falling off. Here we re-examine the stellar disk profiles of 141 dwarfs: 96 dwarf irregulars (dIms), 26 Blue Compact Dwarfs (BCDs), and 19 Magellanic-type spirals (Sms). We fit single, double, or even triple exponential profiles in up to 11 passbands: GALEX FUV and NUV, ground-based UBVJHK and Hα, and Spitzer 3.6 and 4.5 μm. We find that more luminous galaxies have brighter centers, larger inner and outer scale lengths, and breaks at larger radii; dwarf trends with M B extend to spirals. However, the V-band break surface brightness is independent of break type, M B , and Hubble type. Dwarf Type II and III profiles fall off similarly beyond the breaks but have different interiors and IIs break ∼twice as far as IIIs. Outer Type II and III scale lengths may have weak trends with wavelength, but pure Type II inner scale lengths clearly decrease from the FUV to visible bands whereas Type III inner scale lengths increase with redder bands. This suggests the influence of different star formation histories on profile type, but nonetheless the break location is approximately the same in all passbands. Dwarfs continue trends between profile and Hubble types such that later-type galaxies have more Type II but fewer Type I and III profiles than early-type spirals. BCDs and Sms are over-represented as Types III and II, respectively, compared to dIms

  20. Profile structures of TJ-II stellarator plasmas

    NARCIS (Netherlands)

    Herranz, J.; Pastor, I.; Castejon, F.; de la Luna, E.; Garcia-Cortes, I.; Barth, C. J.; Ascasibar, E.; Sanchez, J.; Tribaldos, V.

    2000-01-01

    Fine structures are found in the TJ-II stellarator electron temperature and density profiles, when they are measured using a high spatial resolution Thomson scattering system. These structures consist of peaks and valleys superimposed to a smooth average. Some irregularities remain in an ensemble

  1. Esophagogastric junction outflow obstruction is often associated with coexistent abnormal esophageal body motility and abnormal bolus transit.

    Science.gov (United States)

    Zheng, E; Gideon, R M; Sloan, J; Katz, P O

    2017-10-01

    Currently, the diagnosis of esophageal motility disorders is in part based upon a hierarchical algorithm in which abnormalities of the esophagogastric junction (EGJ) is prioritized. An important metric in evaluating the EGJ is the integrated relaxation pressure (IRP). Patients who do not have achalasia but are found to have an elevated IRP are diagnosed with EGJ outflow obstruction. It has been our observation that a subset of these patients also has a second named motility disorder and may also have abnormal bolus transit. The aim of this study is to determine the frequency of abnormal body motility and or abnormal bolus movement in patients with EGJ outflow obstruction. Further, in an effort to evaluate the potential clinical value in measuring bolus transit as a complement to esophageal manometry, specifically in patients with EGJ outflow obstruction, we analyzed the presenting symptoms of these patients. A total of 807 patients with a mean age of 53 years completed esophageal function testing with impedance monitoring and high-resolution manometry between January 2012 and October 2016. There were 74 patients with achalasia who were excluded from the study. Of the remaining 733 patients, 138 (19%) had an elevated IRP and were given a diagnosis of EGJ outflow obstruction. Among these patients, 56 (40%) were diagnosed with an abnormal motility pattern to liquids (ineffective esophageal motility = 28, distal esophageal spasm = 19, Jackhammer = 6), of which 44 (76%) had abnormal bolus transit to liquids, viscous, or both. In contrast, there were 82 patients with EGJ outflow obstruction and normal esophageal motility, of which 33 (40%) had abnormal bolus transit. Patients with preserved esophageal motility and EGJ outflow obstruction were then evaluated. Of the 733 patients, 299 (40%) had intact esophageal motility. Of the 299 patients with normal esophageal motility, 56 patients had an elevated IRP, of which 16 (28%) had abnormal bolus transit. There were 243 (33

  2. Wire Scanner Beam Profile Measurements for the LANSCE Facility

    Energy Technology Data Exchange (ETDEWEB)

    Gilpatrick, John D. [Los Alamos National Laboratory; Gruchalla, Michael E. [Los Alamos National Laboratory; Martinez, Derwin [Los Alamos National Laboratory; Pillai, Chandra [Los Alamos National Laboratory; Rodriguez Esparza, Sergio [Los Alamos National Laboratory; Sedillo, James Daniel [Los Alamos National Laboratory; Smith, Brian G. [Los Alamos National Laboratory

    2012-05-15

    The Los Alamos Neutron Science Center (LANSCE) is replacing beam profile measurement systems, commonly known as Wire Scanners (WS). Using the principal of secondary electron emission, the WS measurement system moves a wire or fiber across an impinging particle beam, sampling a projected transverse-beam distribution. Because existing WS actuators and electronic components are either no longer manufactured or home-built with antiquated parts, a new WS beam profile measurement is being designed, fabricated, and tested. The goals for these new WS's include using off-the-shelf components while eliminating antiquated components, providing quick operation while allowing for easy maintainability, and tolerating external radioactivation. The WS measurement system consists of beam line actuators, a cable plant, an electronics processor chassis, and software located both in the electronics chassis (National Instruments LabVIEW) and in the Central Control Room (EPICS-based client software). This WS measurement system will measure Hand H{sup +} LANSCE-facility beams and will also measure less common beams. This paper describes these WS measurement systems.

  3. Vocational Training in Asia and the Pacific: A Profile of Bangladesh.

    Science.gov (United States)

    International Labour Office, Islamabad (Pakistan). Asian and Pacific Skill Development Programme.

    This country profile of Bangladesh is one of a series of country profiles intended to give the user a graphic view of the structure, outputs, and legal basis of the vocational training system of individual countries in the Asia-Pacific region. The data, gathered by the Asian and Pacific Skill Development Programme in Pakistan, generally cover the…

  4. The Profiles in Science Digital Library: Behind the Scenes.

    Science.gov (United States)

    Gallagher, Marie E; Moffatt, Christie

    2012-01-01

    This demonstration shows the Profiles in Science ® digital library. Profiles in Science contains digitized selections from the personal manuscript collections of prominent biomedical researchers, medical practitioners, and those fostering science and health. The Profiles in Science Web site is the delivery mechanism for content derived from the digital library system. The system is designed according to our basic principles for digital library development [1]. The digital library includes the rules and software used for digitizing items, creating and editing database records and performing quality control as well as serving the digital content to the public. Among the types of data managed by the digital library are detailed item-level, collection-level and cross-collection metadata, digitized photographs, papers, audio clips, movies, born-digital electronic files, optical character recognized (OCR) text, and annotations (see Figure 1). The digital library also tracks the status of each item, including digitization quality, sensitivity of content, and copyright. Only items satisfying all required criteria are released to the public through the World Wide Web. External factors have influenced all aspects of the digital library's infrastructure.

  5. IHE profiles applied to regional PACS

    International Nuclear Information System (INIS)

    Fernandez-Bayo, Josep

    2011-01-01

    PACS has been widely adopted as an image storage solution that perfectly fits the radiology department workflow and that can be easily extended to other hospital departments. Integrations with other hospital systems, like the Radiology Information System, the Hospital Information System and the Electronic Patient Record are fully achieved but still challenging aims. PACS also creates the perfect environment for teleradiology and teleworking setups. One step further is the regional PACS concept where different hospitals or health care enterprises share the images in an integrated Electronic Patient Record. Among the different solutions available to share images between different hospitals IHE (Integrating the Healthcare Enterprise) organization presents the Cross Enterprise Document Sharing profile (XDS) which allows sharing images from different hospitals even if they have different PACS vendors. Adopting XDS has multiple advantages, images do not need to be duplicated in a central archive to be shared among the different healthcare enterprises, they only need to be indexed and published in a central document registry. In the XDS profile IHE defines the mechanisms to publish and index the images in the central document registry. It also defines the mechanisms that each hospital will use to retrieve those images regardless on the Hospital PACS they are stored.

  6. Least cost planning within the service concept of power supply companies

    International Nuclear Information System (INIS)

    Lueschen, H.; Sonntag, J.; Werner, R.

    1995-01-01

    In discussing the implementation of energy service concepts, German power supply companies are gradually adopting categories originating from the USA, namely integrated resources planning (IRP), least cost planning (LCP), and demand-side management (DSM). While the activities of German power supply companies are more encompassing than those of their US counterparts in the traditional features of DSM such as load management, information, and consulting, further-going measures such as direct investment and financial incentive programmes for exploiting energy-saving potentials play a less important role and are controversial in the energy-political debate. The article presents the concept of power supply companies for implementing IRP/LCP and makes a concrete assessment of the worth and efficiency of consulting compared with the newer type of financial incentive programmes. (orig.) [de

  7. In-Situ Observation of Undisturbed Surface Layer Scaler Profiles for Characterizing Evaporative Duct Properties

    Science.gov (United States)

    2016-06-01

    9 Figure 4. Prototype RHIB-based tethered balloon MAPS used in CASPER Pilot. The...profile measurements over the ocean. The system is designed to make profiling measurements with multiple up/downs using an instrumented tethered balloon ...temperature profiles with high vertical resolution. With the ultimate goal of improving evaporative duct prediction, we use a tethered 2 balloon

  8. Engineered zircaloy cladding modifications for improved accident tolerance of LWR fuel: US DOE NEUP Integrated Research Project

    International Nuclear Information System (INIS)

    Heuser, Brent

    2013-01-01

    An integrated research project (IRP) to fabricate and evaluate modified zircaloy LWR cladding under normal BWR/PWR operation and off-normal events has been funded by the US DOE. The IRP involves three US academic institutions, a US national laboratory, an intermediate stock industrial cladding supplier, and an international academic institution. A combination of computational and experimental protocols will be employed to design and test modified zircaloy cladding with respect to corrosion and accelerated oxide growth, the former associated with normal operation, the latter associated with steam exposure during loss of coolant accidents (LOCAs) and low-pressure core re-floods. Efforts will be made to go beyond design-base accident (DBA) scenarios (cladding temperature equal to or less than 1204 deg. C) during the experimental phase of modified zircaloy performance characterisation. The project anticipates the use of the facilities at ORNL to achieve steam exposure beyond DBA scenarios. In addition, irradiation of down-selected modified cladding candidates in the ATR may be performed. Cladding performance evaluation will be incorporated into a reactor system modelling effort of fuel performance, neutronics, and thermal hydraulics, thereby providing a holistic approach to accident-tolerant nuclear fuel. The proposed IRP brings together personnel, facilities, and capabilities across a wide range of technical areas relevant to the study of modified nuclear fuel and LWR performance during normal operation and off-normal scenarios. Two pathways towards accident-tolerant LWR fuel are envisioned, both based on the modification of existing zircaloy cladding. The first is the modification of the cladding surface by the application of a coating layer designed to shift the M + O→MO reaction away from oxide growth during steam exposure at elevated temperatures. This pathway is referred to as the 'surface coating' solution. The second is the modification of the bulk

  9. Topographic Correction of GPR Profiles Based on Laser Data

    International Nuclear Information System (INIS)

    Zhang, Di; Zhong, Ruofei; Li, Jia Cun; Zeng, Fanyang

    2014-01-01

    Data obtained by GPR (Ground Penetrating Radar) are displayed as a continuous cross-sectional profile. Surface, generally, is not flat. As a result, the image becomes distorted and the depth calculated from the surface no longer represents the true and exact position of electrically distinctive layers and objects in materials. In order to get real geologic cross section, GPR data must be corrected. This is paper discusses a new method using the color point cloud data obtained by a Vehicle-borne laser scanning system to compensate for elevation fluctuate. Elevation profile can be extracted from topographic data of survey site acquired using laser scanner, which can then be used to offset the error of GPR data. Through the discrete points in the survey line, each trace of the profile has its own elevation value showing a vertical difference from the reference profile with maximum elevation, then time shifts value of traces vertical offset versus the reference trace of profile can be obtained. At last, the results of topographic correction for radargrams that look extremely like the real geologic cross section are presented, which allows us to get a better profile interpretation and position of the objects and layers in the subsurface

  10. Quantitative high dynamic range beam profiling for fluorescence microscopy

    International Nuclear Information System (INIS)

    Mitchell, T. J.; Saunter, C. D.; O’Nions, W.; Girkin, J. M.; Love, G. D.

    2014-01-01

    Modern developmental biology relies on optically sectioning fluorescence microscope techniques to produce non-destructive in vivo images of developing specimens at high resolution in three dimensions. As optimal performance of these techniques is reliant on the three-dimensional (3D) intensity profile of the illumination employed, the ability to directly record and analyze these profiles is of great use to the fluorescence microscopist or instrument builder. Though excitation beam profiles can be measured indirectly using a sample of fluorescent beads and recording the emission along the microscope detection path, we demonstrate an alternative approach where a miniature camera sensor is used directly within the illumination beam. Measurements taken using our approach are solely concerned with the illumination optics as the detection optics are not involved. We present a miniature beam profiling device and high dynamic range flux reconstruction algorithm that together are capable of accurately reproducing quantitative 3D flux maps over a large focal volume. Performance of this beam profiling system is verified within an optical test bench and demonstrated for fluorescence microscopy by profiling the low NA illumination beam of a single plane illumination microscope. The generality and success of this approach showcases a widely flexible beam amplitude diagnostic tool for use within the life sciences

  11. Investigating Methods for Serving Visualizations of Vertical Profiles

    Science.gov (United States)

    Roberts, J. T.; Cechini, M. F.; Lanjewar, K.; Rodriguez, J.; Boller, R. A.; Baynes, K.

    2017-12-01

    Several geospatial web servers, web service standards, and mapping clients exist for the visualization of two-dimensional raster and vector-based Earth science data products. However, data products with a vertical component (i.e., vertical profiles) do not have the same mature set of technologies and pose a greater technical challenge when it comes to visualizations. There are a variety of tools and proposed standards, but no obvious solution that can handle the variety of visualizations found with vertical profiles. An effort is being led by members of the NASA Global Imagery Browse Services (GIBS) team to gather a list of technologies relevant to existing vertical profile data products and user stories. The goal is to find a subset of technologies, standards, and tools that can be used to build publicly accessible web services that can handle the greatest number of use cases for the widest audience possible. This presentation will describe results of the investigation and offer directions for moving forward with building a system that is capable of effectively and efficiently serving visualizations of vertical profiles.

  12. Measurement of high-beta tokamak pressure profiles with multipoint Thomson scattering

    International Nuclear Information System (INIS)

    Levinton, F.M.

    1983-01-01

    A multipoint Thomson-scattering system has been developed to obtain pressure profiles along the major radius of Torus II, a high-beta tokamak. The profiles obtained during the 20 to 25 μs lifetime of the discharge indicates that the plasma has a peak temperature of 80 eV and density of 1.0 x 10 15 cm - 3 . The profiles remain fairly constant during this time until the equilibrium is lost, after which the temperature and density decays to 10 eV and 10 14 cm - 3 very quickly (approx. 1 μs). Experimental results show Torus II has a high-beta ( approx. 10%) equilibrium, with a strong shift of the peak of the pressure profile towards the outside. Numerical results from a 2-D free boundary MHD equilibrium code have obtained equilibria which closely approximate the experimentally measured profiles

  13. Comparisons of Airborne HSRL and Modeled Aerosol Profiles

    Science.gov (United States)

    Ferrare, R. A.; Burton, S. P.; Hostetler, C. A.; Hair, J. W.; Ismail, S.; Rogers, R. R.; Notari, A.; Berkoff, T.; Butler, C. F.; Collins, J. E., Jr.; Fenn, M. A.; Scarino, A. J.; Clayton, M.; Mueller, D.; Chemyakin, E.; Fast, J. D.; Berg, L. K.; Randles, C. A.; Colarco, P. R.; daSilva, A.

    2014-12-01

    Aerosol profiles derived from a regional and a global model are compared with aerosol profiles acquired by NASA Langley Research Center (LaRC) airborne High Spectral Resolution Lidars (HSRLs) during recent field missions. We compare simulated aerosol profiles obtained from the WRF-Chem regional model with those measured by the airborne HSRL-2 instrument over the Atlantic Ocean east of Cape Cod in July 2012 during the Department of Energy Two-Column Aerosol Project (TCAP). While deployed on the LaRC King Air during TCAP, HSRL-2 acquired profiles of aerosol extinction at 355 and 532 nm, as well as aerosol backscatter and depolarization at 355, 532, and 1064 nm. Additional HSRL-2 data products include profiles of aerosol type, mixed layer depth, and aerosol microphysical parameters (e.g. effective radius, concentration). The HSRL-2 and WRF-Chem aerosol profiles are compared along the aircraft flight tracks. HSRL-2 profiles acquired during the NASA Deriving Information on Surface Conditions from COlumn and VERtically Resolved Observations Relevant to Air Quality (DISCOVER-AQ) mission over Houston during September 2013 are compared with the NASA Goddard Earth Observing System global model, version 5 (GEOS-5) profiles. In addition to comparing backscatter and extinction profiles, the fraction of aerosol extinction and optical thickness from various aerosol species from GEOS-5 are compared with aerosol extinction and optical thickness contributed by aerosol types derived from HSRL-2 data. We also compare aerosol profiles modeled by GEOS-5 with those measured by the airborne LaRC DIAL/HSRL instrument during August and September 2013 when it was deployed on the NASA DC-8 for the Studies of Emissions and Atmospheric Composition, Clouds and Climate Coupling by Regional Surveys (SEAC4RS) mission. DIAL/HSRL measured extinction (532 nm), backscatter (532 and 1064 nm), and depolarization profiles (532 and 1064 nm) in both nadir and zenith directions during long transects over the

  14. Net-erosion profile model and simulation experiments

    International Nuclear Information System (INIS)

    Sagara, Akio

    2001-01-01

    Estimation of net-erosion profile is requisite for evaluating the lifetime of divertor plates under high heat and particle fluxes of fusion plasmas. As a reference in benchmark tests of numerical calculation codes, a self-consistent analytical solution is presented for a simplified divertor condition, wherein the magnetic field line is normal to the target plate and the ionization mean free path of sputtered particles is assumed constant. The primary flux profile of hydrogen and impurities are externally given as well as the return ratio of sputtered atoms to the target. In the direction along the divertor trace, all conditions are uniform. The analytical solution is compared with net-erosion experiments carried out using the Compact Helical System (CHS). The deposition profiles of Ti and O impurities are in very good agreement with the analytical predictions. Recent preliminary results observed on divertor plates in the Large Helical Device (LHD) are briefly presented. (author)

  15. Observability of plant metabolic networks is reflected in the correlation of metabolic profiles

    DEFF Research Database (Denmark)

    Schwahn, Kevin; Küken, Anika; Kliebenstein, Daniel James

    2016-01-01

    to obtain information about the entire system. Yet, the extent to which the data profiles reflect the role of components in the observability of the system remains unexplored. Here we first identify the sensor metabolites in the model plant Arabidopsis (Arabidopsis thaliana) by employing state...... with in silico generated metabolic profiles from a medium-size kinetic model of plant central carbon metabolism. Altogether, due to the small number of identified sensors, our study implies that targeted metabolite analyses may provide the vast majority of relevant information about plant metabolic systems....

  16. Code Description for Generation of Meteorological Height and Pressure Level and Layer Profiles

    Science.gov (United States)

    2016-06-01

    defined by user input height or pressure levels. It can process input profiles from sensing systems such as radiosonde, lidar, or wind profiling radar...routine may be required for different input types and formats. meteorological sounding interpolation , integrated mean layer values, US Army Research...or other radiosonde soundings. There are 2 main versions or “methods” that produce output in height- or pressure-based profiles of interpolated level

  17. Effects of Dietary Lycopene Supplementation on Plasma Lipid Profile, Lipid Peroxidation and Antioxidant Defense System in Feedlot Bamei Lamb.

    Science.gov (United States)

    Jiang, Hongqin; Wang, Zhenzhen; Ma, Yong; Qu, Yanghua; Lu, Xiaonan; Luo, Hailing

    2015-07-01

    Lycopene, a red non-provitamin A carotenoid, mainly presenting in tomato and tomato byproducts, has the highest antioxidant activity among carotenoids because of its high number of conjugated double bonds. The objective of this study was to investigate the effect of lycopene supplementation in the diet on plasma lipid profile, lipid peroxidation and antioxidant defense system in feedlot lamb. Twenty-eight Bamei male lambs (90 days old) were divided into four groups and fed a basal diet (LP0, 40:60 roughage: concentrate) or the basal diet supplemented with 50, 100, and 200 mg/kg lycopene. After 120 days of feeding, all lambs were slaughtered and sampled. Dietary lycopene supplementation significantly reduced the levels of plasma total cholesterol (p0.05). The levels of TG (pCAT, pCAT (p<0.05, linearly) and SOD (p<0.001, linearly). Therefore, it was concluded that lycopene supplementation improved the antioxidant status of the lamb and optimized the plasma lipid profile, the dosage of 200 mg lycopene/kg feed might be desirable for growing lambs to prevent environment stress and maintain normal physiological metabolism.

  18. BWR AXIAL PROFILE

    International Nuclear Information System (INIS)

    Huffer, J.

    2004-01-01

    The purpose of this calculation is to develop axial profiles for estimating the axial variation in burnup of a boiling water reactor (BWR) assembly spent nuclear fuel (SNF) given the average burnup of an assembly. A discharged fuel assembly typically exhibits higher burnup in the center and lower burnup at the ends of the assembly. Criticality safety analyses taking credit for SNF burnup must account for axially varying burnup relative to calculations based on uniformly distributed assembly average burnup due to the under-burned tips. Thus, accounting for axially varying burnup in criticality analyses is also referred to as accounting for the ''end effect'' reactivity. The magnitude of the reactivity change due to ''end effect'' is dependent on the initial assembly enrichment, the assembly average burnup, and the particular axial profile characterizing the burnup distribution. The set of bounding axial profiles should incorporate multiple BWR core designs and provide statistical confidence (95 percent confidence that 95 percent of the population is bound by the profile) that end nodes are conservatively represented. The profiles should also conserve the overall burnup of the fuel assembly. More background on BWR axial profiles is provided in Attachment I

  19. Laser Range Profiling for Active Protection System Target Classification and Aim-Point Selection

    National Research Council Canada - National Science Library

    Jones, Michael

    2004-01-01

    .... The attractiveness of smaller, faster interceptors precipitated the investigation of a laser radar sensor augmentation for CIAPS that could quickly resolve the range profile of an incoming projectile...

  20. Edge density profiles in high-performance JET plasmas

    International Nuclear Information System (INIS)

    Summers, D.D.R.; Viaccoz, B.; Vince, J.

    1997-01-01

    Detailed electron density profiles of the scrape-off layer in high-performance JET plasmas (plasma current, I p nbi ∝17 MW) have been measured by means of a lithium beam diagnostic system featuring high spatial resolution [Kadota (1978)[. Measurements were taken over a period of several seconds, allowing examination of the evolution of the edge profile at a location upstream from the divertor target. The data clearly show the effects of the H-mode transition - an increase in density near the plasma separatrix and a reduction in density scrape-off length. The profiles obtained under various plasma conditions are compared firstly with data from other diagnostics, located elsewhere in the vessel, and also with the predictions of an 'onion-skin' model (DIVIMP), which used, as initial parameters, data from an array of probes located in the divertor target. (orig.)

  1. Chloride ingress profiles measured by electron probe micro analysis

    DEFF Research Database (Denmark)

    Jensen, Ole mejlhede; Coats, Alison M.; Glasser, Fred P.

    1996-01-01

    Traditional techniques for measuring chloride ingress profiles do not apply well to high performance cement paste systems; the geometric resolution of the traditional measuring techniques is too low. In this paper measurements by Electron Probe Micro Analysis (EPMA) are presented. EPMA is demonst......Traditional techniques for measuring chloride ingress profiles do not apply well to high performance cement paste systems; the geometric resolution of the traditional measuring techniques is too low. In this paper measurements by Electron Probe Micro Analysis (EPMA) are presented. EPMA...... is demonstated to determine chloride ingress in cement paste on a micrometer scale. Potential chloride ingress routes such as cracks or the paste-aggregate interface may also be characterized by EPMA. Copyright (C) 1996 Elsevier Science Ltd...

  2. Narrow power deposition profiles on the JET divertor target

    International Nuclear Information System (INIS)

    Lingertat, J.; Laux, M.; Monk, R.

    2001-01-01

    One of the key unresolved issues in the design of a future fusion reactor is the power handling capability of the divertor target plates. Earlier we reported on the existence of narrow power deposition profiles in JET, obtained mainly from Langmuir probe measurements. We repeated these measurements in the MkI, MkII and MkIIGB divertor configurations with an upgraded probe system, which allowed us to study the profile shape in more detail. The main results of this study are: In NB heated discharges the electron temperature and power flux at the outer target show a distinct peak of ∼5 mm half-width near the separatrix strike point. The corresponding profiles on the inner target do not show a similar feature. The height of the narrow peak increases with NB heating power and decreases with deuterium and impurity gas puffing. Ion orbit losses are suggested as a possible explanation of the observed profile shape

  3. Impact of the Road Profile on Vehicle Deceleration

    Directory of Open Access Journals (Sweden)

    Vidas Žuraulis

    2012-11-01

    Full Text Available The article analyzes the impact of the longitudinal road profile on the efficiency of car braking estimated applying deceleration value. Different formulas are used for theoretical calculations, and therefore experimental brakes in different road slopes were performed to obtain the most accurate results. Deceleration, as one of the most important safety parameters, depends on the technical condition of the braking system, road conditions and structural and dynamic properties of the other car. Road alignments can significantly affect car manageability, because of weight transfer and extra track resistance, which may change the overall balance of the car and affect the nature of dynamic characteristics that may vary from certain critical values. The results of corrections to deceleration dependence on the road profile can be used for investigating traffic accidents, optimizing traffic control arrangements and implementing advanced systems for automotive active safety.

  4. The Integrated Renovation Process

    DEFF Research Database (Denmark)

    Galiotto, Nicolas; Heiselberg, Per; Knudstrup, Mary-Ann

    The Integrated Renovation Process (IRP) is a user customized methodology based on judiciously selected constructivist and interactive multi-criteria decision making methods (Galiotto, Heiselberg, & Knudstrup, 2014 (expected)). When applied for home renovation, the Integrated Renovation Process...

  5. Soil Vapor Extraction and Bioventing Test Work Plan for the MOGAS Site, Myrtle Beach Air Force Base, South Carolina

    National Research Council Canada - National Science Library

    1995-01-01

    This work plan presents an evaluation of soil vapor extraction (SVE) and bioventing, and describes the SVE pilot scale and bioventing activities to be conducted to extract and treat soil gas at Installation Restoration Program (IRP...

  6. Diagnose Test-Taker's Profile in Terms of Core Profile Patterns: Principal Component (PC) vs. Profile Analysis via MDS (PAMS) Approaches.

    Science.gov (United States)

    Kim, Se-Kang; Davison, Mark L.

    A study was conducted to examine how principal components analysis (PCA) and Profile Analysis via Multidimensional Scaling (PAMS) can be used to diagnose individuals observed score profiles in terms of core profile patterns identified by each method. The standardization sample from the Wechsler Intelligence Scale for Children, Third Edition…

  7. Similar chemokine receptor profiles in lymphomas with central nervous system involvement - possible biomarkers for patient selection for central nervous system prophylaxis, a retrospective study.

    Science.gov (United States)

    Lemma, Siria A; Pasanen, Anna Kaisa; Haapasaari, Kirsi-Maria; Sippola, Antti; Sormunen, Raija; Soini, Ylermi; Jantunen, Esa; Koivunen, Petri; Salokorpi, Niina; Bloigu, Risto; Turpeenniemi-Hujanen, Taina; Kuittinen, Outi

    2016-05-01

    Central nervous system (CNS) relapse occurs in around 5% of diffuse large B-cell lymphoma (DLBCL) cases. No biomarkers to identify high-risk patients have been discovered. We evaluated the expression of lymphocyte-guiding chemokine receptors in systemic and CNS lymphomas. Immunohistochemical staining for CXCR4, CXCR5, CCR7, CXCL12, and CXCL13 was performed on 89 tissue samples, including cases of primary central nervous system lymphoma (PCNSL), secondary CNS lymphoma (sCNSL), and systemic DLBCL. Also, 10 reactive lymph node samples were included. Immunoelectron microscopy was performed on two PCNSLs, one sCNSL, one systemic DLBCL, and one reactive lymph node samples, and staining was performed for CXCR4, CXCR5, CXCL12, and CXCL13. Chi-square test was used to determine correlations between clinical parameters, diagnostic groups, and chemokine receptor expression. Strong nuclear CXCR4 positivity correlated with systemic DLBCL, whereas strong cytoplasmic CXCR5 positivity correlated with CNS involvement (P = 0.003 and P = 0.039). Immunoelectron microscopy revealed a nuclear CXCR4 staining in reactive lymph node, compared with cytoplasmic and membranous localization seen in CNS lymphomas. We found that CNS lymphoma presented a chemokine receptor profile different from systemic disease. Our findings give new information on the CNS tropism of DLBCL and, if confirmed, may contribute to more effective targeting of CNS prophylaxis among patients with DLBCL. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  8. Creating preservation metadata from XML-metadata profiles

    Science.gov (United States)

    Ulbricht, Damian; Bertelmann, Roland; Gebauer, Petra; Hasler, Tim; Klump, Jens; Kirchner, Ingo; Peters-Kottig, Wolfgang; Mettig, Nora; Rusch, Beate

    2014-05-01

    Registration of dataset DOIs at DataCite makes research data citable and comes with the obligation to keep data accessible in the future. In addition, many universities and research institutions measure data that is unique and not repeatable like the data produced by an observational network and they want to keep these data for future generations. In consequence, such data should be ingested in preservation systems, that automatically care for file format changes. Open source preservation software that is developed along the definitions of the ISO OAIS reference model is available but during ingest of data and metadata there are still problems to be solved. File format validation is difficult, because format validators are not only remarkably slow - due to variety in file formats different validators return conflicting identification profiles for identical data. These conflicts are hard to resolve. Preservation systems have a deficit in the support of custom metadata. Furthermore, data producers are sometimes not aware that quality metadata is a key issue for the re-use of data. In the project EWIG an university institute and a research institute work together with Zuse-Institute Berlin, that is acting as an infrastructure facility, to generate exemplary workflows for research data into OAIS compliant archives with emphasis on the geosciences. The Institute for Meteorology provides timeseries data from an urban monitoring network whereas GFZ Potsdam delivers file based data from research projects. To identify problems in existing preservation workflows the technical work is complemented by interviews with data practitioners. Policies for handling data and metadata are developed. Furthermore, university teaching material is created to raise the future scientists awareness of research data management. As a testbed for ingest workflows the digital preservation system Archivematica [1] is used. During the ingest process metadata is generated that is compliant to the

  9. Spectral backward radiation profile

    International Nuclear Information System (INIS)

    Kwon, Sung Duck; Lee, Keun Hyun; Kim, Bo Ra; Yoon, Suk Soo

    2004-01-01

    Ultrasonic backward radiation profile is frequency-dependent when incident region has deptional gradient of acoustical properties or multi-layers. Until now, we have measured the profiles of principal frequencies of used transducers so that it was not easy to understand the change of the frequency component and spectrum of backward radiation from the profile. We tried to measure the spectral backward radiation profiles using DFP(digital filer package) Lecroy DSO. The very big changes in the shape and pattern of spectral backward radiation profiles leads to the conclusion that this new try could be very effective tool to evaluate frequency dependent surface area.

  10. Position sensitive detector used to detect beam profile

    International Nuclear Information System (INIS)

    Zhao Xiaoyan; Zhao Zhizheng; Zu Kailing; Zheng Jianhua; Wang Yifang

    2003-01-01

    In order to study the detecting system of the residual-gas beam profile, we introduce the principle and construction of the Position Sensitive Detector (PSD). The performance of PSD is tested. Position resolution, position linearity, detection efficiency and background are obtained

  11. Atmospheric profiles from active space-based radio measurements

    Science.gov (United States)

    Hardy, Kenneth R.; Hinson, David P.; Tyler, G. L.; Kursinski, E. R.

    1992-01-01

    The paper describes determinations of atmospheric profiles from space-based radio measurements and the retrieval methodology used, with special attention given to the measurement procedure and the characteristics of the soundings. It is speculated that reliable profiles of the terrestrial atmosphere can be obtained by the occultation technique from the surface to a height of about 60 km. With the full complement of 21 the Global Positioning System (GPS) satellites and one GPS receiver in sun synchronous polar orbit, a maximum of 42 soundings could be obtained for each complete orbit or about 670 per day, providing almost uniform global coverage.

  12. Spatial profiling of ion and neutral excitation in noble gas electron cyclotron resonance plasmas

    International Nuclear Information System (INIS)

    Rhoades, R.L.; Gorbatkin, S.M.

    1994-01-01

    Optical emission from neutrals and ions of several noble gases has been profiled in an electron cyclotron resonance plasma system. In argon plasmas with a net microwave power of 750 W, the neutral (696.5-nm) and ion (488-nm) emission profiles are slightly center peaked at 0.32 mTorr and gradually shift to a hollow appearance at 2.5 mTorr. Neon profiles show a similar trend from 2.5 to 10.0 mTorr. For the noble gases, transition pressure scales with the ionization potential of the gas, which is consistent with neutral depletion. Studies of noble gas mixtures, however, indicate that neutral depletion is not always dominant in the formation of hollow profiles. For Kr/Ar, Ar/Ne, and Ne/He plasmas, the majority gas tends to set the overall shape of the profile at any given pressure. For the conditions of the current system, plasma density appears to be more dominant than electron temperature in the formation of hollow profiles. The general method described is also a straightforward, inexpensive technique for measuring the spatial distribution of power deposited in plasmas, particularly where absolute scale can be calibrated by some other means

  13. Energy, Environmental and Economic Performance of a Micro-trigeneration System upon Varying the Electric Vehicle Charging Profiles

    Directory of Open Access Journals (Sweden)

    Sergio Sibilio

    2017-09-01

    Full Text Available The widespread adoption of electric vehicles and electric heat pumps would result in radically different household electrical demand characteristics, while also possibly posing a threat to the stability of the electrical grid. In this paper, a micro-trigeneration system (composed of a 6.0 kWel cogeneration device feeding a 4.5 kWcool electric air-cooled vapor compression water chiller serving an Italian residential multi-family house was investigated by using the dynamic simulation software TRNSYS. The charging of an electric vehicle was considered by analyzing a set of seven electric vehicle charging profiles representing different scenarios. The simulations were performed in order to evaluate the capability of micro-cogeneration technology in: alleviating the impact on the electric infrastructure (a; saving primary energy (b; reducing the carbon dioxide equivalent emissions (c and determining the operating costs in comparison to a conventional supply system based on separate energy production (d.

  14. DYNAMIC MEMORY ALLOCATION – CLR PROFILER

    Directory of Open Access Journals (Sweden)

    Adrian LUPASC

    2014-06-01

    Full Text Available At the present time, information systems are an important component in the development of many activities, due to their ability of managing a large amount of data and performing complex operations in a very short time. In this regard, very important is the correct management of all available resources, especially memory management. Haven’t happened to test an application, but it runs out of memory? This paper is trying to explain some of the situations causing those problems and also is trying to find some solutions for fixing them. Concluding, the purpose of this paper is to emphasize on one hand the importance of using a memory profiler in the development of your applications and on the other hand, the advantages brought by CLR Profiler on your .NET applications.

  15. Use of professional profiles in applications for specialist training positions.

    Science.gov (United States)

    Lundh, Andreas; Skjelsager, Karen; Wildgaard, Kim

    2013-07-01

    The seven roles of the CanMEDS system have been implemented in Danish postgraduate medical training. For each medical specialty, a professional profile describes which elements of the seven roles the specialty deems important for applicants for a specialist training position. We investigated use of professional profiles among the 38 Danish specialty societies in order to ascertain the use of the seven roles. We used information from the websites of the Postgraduate Medical Training Secretariats in March 2012. For each profile, we extracted information on how the seven roles were described, how the roles were ranked by importance, whether a score sheet was used by the appointment committee and whether the profile had been updated. Twenty-four (63%) of the 38 profiles described the contents for all of the seven roles and four (11%) described the contents only for some of the roles. Nine specialties (24%) described a clear ranking of the seven roles with the medical expert and scholar roles generally ranked as most important. Seven specialties (18%) used standardised score sheets as part of the application process. Four (11%) specialties had updated their professional profiles. The majority of specialties described the seven roles in their professional profiles, but the level of detail varied substantially. Few specialties described whether the roles were ranked by importance or provided specific guidelines for appointment committees on how the contents of the profiles should be interpreted. We suggest that specialties seek inspiration for updating their profiles, and that they use the contents from all specialties provided at a website. not relevant. not relevant.

  16. A high resolution wire scanner beam profile monitor with a microprocessor data acquisition system

    International Nuclear Information System (INIS)

    Cutler, R.I.; Mohr, D.L.; Whittaker, J.K.; Yoder, N.R.

    1983-01-01

    A beam profile monitor has been constructed for the NBS-LANL Racetrack Microtron. The monitor consists of two perpendicular 30 μm diameter carbon wires that are driven through an electron beam by a pneumatic actuator. A long-lifetime, electroformed nickel bellows is used for the linear-motion vacuum feedthrough. Secondary emission current from the wires and a signal from a transducer measuring the position of the wires are simultaneously digitized by a microprocessor to yield beam current density profiles in two dimensions. The wire scanner is designed for use with both pulsed and cw beams

  17. A Simultaneous Density-Integral System for Estimating Stem Profile and Biomass: Slash Pine and Willow Oak

    Science.gov (United States)

    Bernard R. Parresol; Charles E. Thomas

    1996-01-01

    In the wood utilization industry, both stem profile and biomass are important quantities. The two have traditionally been estimated separately. The introduction of a density-integral method allows for coincident estimation of stem profile and biomass, based on the calculus of mass theory, and provides an alternative to weight-ratio methodology. In the initial...

  18. PBX-M upgrade for advanced stabilization and profile control studies

    International Nuclear Information System (INIS)

    Kugel, H.W.; Kozub, T.; Barnes, G.

    1995-01-01

    PBX-M upgrades have been in progress for enhanced capability and reliability. These include upgrades to the vessel O-ring system for impurity control, the Ion Bernstein Wave and Lower Hybrid Current Drive Systems for plasma profile control, a double viewing upper and lower CHERS based Poloidal Rotation Diagnostic, and a new digital plasma control system

  19. Investigation of fitting capability of active mirror for controlling ICF's focal profile

    International Nuclear Information System (INIS)

    Zeng Zhige; Ling Ning; Jiang Wenhan

    1998-01-01

    Laser beam's profile at focal plane can be controlled using active mirror in ICF system because the beam's profile has strong relationship with the surface of active mirror, the surface of active mirror can be changed at any time and maintained for a long time. The capabilities of fitting given wave-front (computed by Geometric Transformation Method) at conditions of different actuator numbers and different arrangement have been investigated by computer simulation. The computing results present that the needed laser profile can obtained by adaptive optical technology

  20. Production of high energy, uniform focal profiles with the Nike laser

    Science.gov (United States)

    Lehecka, T.; Lehmberg, R. H.; Deniz, A. V.; Gerber, K. A.; Obenschain, S. P.; Pawley, C. J.; Pronko, M. S.; Sullivan, C. A.

    1995-02-01

    Nike, a KrF laser facility at the Naval Research Laboratory, is designed to produce high intensity, ultra-uniform focal profiles for experiments relating to direct drive inertial confinement fusion. We present measurements of focal profiles through the next-to-last amplifier, a 20 × 20 cm 2 aperture electron beam pumped amplifier capable of producing more than 120 J of output in a 120 ns pulse. Using echelon free induced spatial incoherence beam smoothing this system has produced focal profiles with less than 2% tilt and curvature and less than 2% rms variation from a flat top distribution.