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Sample records for profile scores obtained

  1. Biophysical profile scores and resistance indices of the umbilical ...

    African Journals Online (AJOL)

    Objective: The role of Biophysical Profile Score and resistive index of the umbilical artery for monitoring pre-eclampsia patients. Design: Descriptive prospective study. Setting: Kenyatta National Hospital and Mater Hospital, Nairobi, Kenya. Subjects: One hundred and ten cases during a three month period. Results: Normal ...

  2. Comparison of Nasalance scores obtained with the Nasometer 6200 and the Nasometer II 6400.

    Science.gov (United States)

    Watterson, Thomas; Lewis, Kerry; Brancamp, Tami

    2005-09-01

    This study was designed to compare nasalance scores obtained with the old Nasometer 6200 and the new Nasometer II 6400, and to evaluate test-retest reliability of nasalance scores on each machine. Nasalance scores were obtained for 60 subjects reading each of two stimuli. Each subject read each stimulus two times on one machine; the headgear was removed and replaced and each stimulus was read a third time. The same procedure was then repeated with the second machine. Within machines, nasalance scores were compared for repeated stimuli with and without headgear change. The first reading of each stimulus with each machine was used to compare nasalance scores across machines. The subjects were 60 adults with normal speech ranging in age from 19 to 59 years. The main outcome measures were the 12 nasalance scores obtained for each of 60 subjects. For both passages, there was a significant difference in nasalance scores between the old Nasometer and the Nasometer II; however, the actual variability that could be attributed to a difference between machines was small. Most of the variability between machines could be explained as within-subject performance variability and variability associated with headgear change. There was no significant difference in repeated scores within machines with or without headgear change. For clinical purposes, care should be exercised when comparing nasalance scores between the old Nasometer and the Nasometer II.

  3. Comparison of nasalance scores obtained from the Nasometer and the NasalView.

    Science.gov (United States)

    Lewis, Kerry E; Watterson, Thomas

    2003-01-01

    Nasalance scores obtained from the Nasometer and the NasalView were compared for five different sentences. Vowel content was controlled in the design of the five stimulus sentences. One sentence was loaded with high-front vowels, one with high-back vowels, one with low-front vowels, one with low-back vowels, and one contained a mixture of vowel types. The subjects were 50 elementary school children ranging from kindergarten to sixth grade. Each subject was a native speaker of English, had no history of adenoidectomy, and was not currently enrolled in speech therapy services. The main outcome measures were the nasalance scores obtained from the Nasometer and the NasalView for each of the five sentences. There was a significant difference in the nasalance scores between the Nasometer and the NasalView for four of the five stimuli, but not all differences were in the same direction. For two stimuli, the Nasometer scores were significantly higher, and for two stimuli the NasalView scores were higher. Bivariate correlations between nasalance scores for individual stimuli were in the good range for the Nasometer but poor for the NasalView. Speech stimuli weighted with different vowel types are differentially affected by the different acoustical filtering used in the Nasometer versus the NasalView. Nasalance scores obtained with the NasalView were qualitatively and quantitatively different from those obtained with the Nasometer. This suggests that the two machines provide different information, and the scores are not interchangeable.

  4. Gait Deviation Index, Gait Profile Score and Gait Variable Score in children with spastic cerebral palsy

    DEFF Research Database (Denmark)

    Rasmussen, Helle Mätzke; Nielsen, Dennis Brandborg; Pedersen, Niels Wisbech

    2015-01-01

    Abstract The Gait Deviation Index (GDI) and Gait Profile Score (GPS) are the most used summary measures of gait in children with cerebral palsy (CP). However, the reliability and agreement of these indices have not been investigated, limiting their clinimetric quality for research and clinical...... practice. The aim of this study was to investigate the intra-rater reliability and agreement of summary measures of gait (GDI; GPS; and the Gait Variable Score (GVS) derived from the GPS). The intra-rater reliability and agreement were investigated across two repeated sessions in 18 children aged 5...

  5. Comparison of nasalance scores obtained with the nasometers 6200 and 6450.

    Science.gov (United States)

    de Boer, Gillian; Bressmann, Tim

    2014-01-01

    The study had the goal of comparing the new Nasometer 6450 to the older model 6200 using synthetic test sounds and control participants. A particular focus of the investigation was on the test-retest variability of the instruments. The Nasometers 6200 and 6450 were compared using square wave test sounds. Six repeated measurements of oral, balanced, and nasal test stimuli were recorded from 25 female participants over an average of 35 days. The synthetic test sounds demonstrated that the two nasometers obtained similar results for a range of frequencies. The results for the clinically normal participants revealed that nasalance scores from the two instruments were within 1-2 points, depending on the test sentence. Variability in scores increased with the proportion of nasal consonants in the sentence. Test-retest variability was between 6 and 8 points for more than 90% of the participants. Participants with higher nasalance scores for oral stimuli had higher between-session variability. The Nasometers 6200 and 6450 should yield comparable results in clinical practice. Depending on the phonetic content of the test materials, clinicians should allow for a 6- to 8-point between-session variability when interpreting nasalance scores.

  6. Gait profile score and movement analysis profile in patients with Parkinson's disease during concurrent cognitive load

    Science.gov (United States)

    Speciali, Danielli S.; Oliveira, Elaine M.; Cardoso, Jefferson R.; Correa, João C. F.; Baker, Richard; Lucareli, Paulo R. G.

    2014-01-01

    Background: Gait disorders are common in individuals with Parkinson's Disease (PD) and the concurrent performance of motor and cognitive tasks can have marked effects on gait. The Gait Profile Score (GPS) and the Movement Analysis Profile (MAP) were developed in order to summarize the data of kinematics and facilitate understanding of the results of gait analysis. Objective: To investigate the effectiveness of the GPS and MAP in the quantification of changes in gait during a concurrent cognitive load while walking in adults with and without PD. Method: Fourteen patients with idiopathic PD and nine healthy subjects participated in the study. All subjects performed single and dual walking tasks. The GPS/MAP was computed from three-dimensional gait analysis data. Results: Differences were found between tasks for GPS (PGait Variable Score (GVS) (pelvic rotation, knee flexion-extension and ankle dorsiflexion-plantarflexion) (Pgait impairment during the dual task and suggest that GPS/MAP may be used to evaluate the effects of concurrent cognitive load while walking in patients with PD. PMID:25054382

  7. Individual Part Score Profiles of Children with Intellectual Disability: A Descriptive Analysis across Three Intelligence Tests

    Science.gov (United States)

    Bergeron, Renee; Floyd, Randy G.

    2013-01-01

    This study examined the group- and individual-level part score profiles of children with intellectual disability (ID) who participated in clinical validity studies supporting three individually administered intelligence tests. Across tests, children with ID produced group-level profiles comprising mean part scores that fell in the Low to Very Low…

  8. A Score Function for State of Charge Profiles for Rechargeable Batteries

    NARCIS (Netherlands)

    Ramsgaard Wognsen, Erik; Jongerden, M.R.; Haverkort, Boudewijn R.H.M.

    2015-01-01

    We propose a new score function to compare and evaluate the relative impact of state-of-charge profiles on overall battery lifetime. Our score function, based on on a discrete Fourier transform of the state-of-charge profile, formalizes and generalizes earlier ideas found in the literature, and can

  9. Genetic Interaction Score (S-Score) Calculation, Clustering, and Visualization of Genetic Interaction Profiles for Yeast.

    Science.gov (United States)

    Roguev, Assen; Ryan, Colm J; Xu, Jiewei; Colson, Isabelle; Hartsuiker, Edgar; Krogan, Nevan

    2017-07-21

    This protocol describes computational analysis of genetic interaction screens, ranging from data capture (plate imaging) to downstream analyses. Plate imaging approaches using both digital camera and office flatbed scanners are included, along with a protocol for the extraction of colony size measurements from the resulting images. A commonly used genetic interaction scoring method, calculation of the S-score, is discussed. These methods require minimal computer skills, but some familiarity with MATLAB and Linux/Unix is a plus. Finally, an outline for using clustering and visualization software for analysis of resulting data sets is provided. © 2018 Cold Spring Harbor Laboratory Press.

  10. Gait profile score and movement analysis profile in patients with Parkinson's disease during concurrent cognitive load

    Directory of Open Access Journals (Sweden)

    Danielli S. Speciali

    2014-08-01

    Full Text Available Background: Gait disorders are common in individuals with Parkinson's Disease (PD and the concurrent performance of motor and cognitive tasks can have marked effects on gait. The Gait Profile Score (GPS and the Movement Analysis Profile (MAP were developed in order to summarize the data of kinematics and facilitate understanding of the results of gait analysis. Objective: To investigate the effectiveness of the GPS and MAP in the quantification of changes in gait during a concurrent cognitive load while walking in adults with and without PD. Method: Fourteen patients with idiopathic PD and nine healthy subjects participated in the study. All subjects performed single and dual walking tasks. The GPS/MAP was computed from three-dimensional gait analysis data. Results: Differences were found between tasks for GPS (P<0.05 and Gait Variable Score (GVS (pelvic rotation, knee flexion-extension and ankle dorsiflexion-plantarflexion (P<0.05 in the PD group. An interaction between task and group was observed for GPS (P<0.01 for the right side (Cohen's ¯d=0.99, left side (Cohen's ¯d=0.91, and overall (Cohen's ¯d=0.88. No interaction was observed only for hip internal-external rotation and foot internal-external progression GVS variables in the PD group. Conclusions: The results showed gait impairment during the dual task and suggest that GPS/MAP may be used to evaluate the effects of concurrent cognitive load while walking in patients with PD.

  11. A Mathematical Technique for Estimating True Temperature Profiles of Data Obtained from Long Time Constant Thermocouples

    National Research Council Canada - National Science Library

    Young, Graeme

    1998-01-01

    A mathematical modeling technique is described for estimating true temperature profiles of data obtained from long time constant thermocouples, which were used in fuel fire tests designed to determine...

  12. Reliability of Scores Obtained from Self-, Peer-, and Teacher-Assessments on Teaching Materials Prepared by Teacher Candidates

    Science.gov (United States)

    Nalbantoglu Yilmaz, Funda

    2017-01-01

    This study aims to determine the reliability of scores obtained from self-, peer-, and teacher-assessments in terms of teaching materials prepared by teacher candidates. The study group of this research constitutes 56 teacher candidates. In the scope of research, teacher candidates were asked to develop teaching material related to their study.…

  13. A general equation to obtain multiple cut-off scores on a test from multinomial logistic regression.

    Science.gov (United States)

    Bersabé, Rosa; Rivas, Teresa

    2010-05-01

    The authors derive a general equation to compute multiple cut-offs on a total test score in order to classify individuals into more than two ordinal categories. The equation is derived from the multinomial logistic regression (MLR) model, which is an extension of the binary logistic regression (BLR) model to accommodate polytomous outcome variables. From this analytical procedure, cut-off scores are established at the test score (the predictor variable) at which an individual is as likely to be in category j as in category j+1 of an ordinal outcome variable. The application of the complete procedure is illustrated by an example with data from an actual study on eating disorders. In this example, two cut-off scores on the Eating Attitudes Test (EAT-26) scores are obtained in order to classify individuals into three ordinal categories: asymptomatic, symptomatic and eating disorder. Diagnoses were made from the responses to a self-report (Q-EDD) that operationalises DSM-IV criteria for eating disorders. Alternatives to the MLR model to set multiple cut-off scores are discussed.

  14. Comparison of arterial blood pressure measurements and hypertension scores obtained by use of three indirect measurement devices in hospitalized dogs.

    Science.gov (United States)

    Wernick, Morena B; Höpfner, Robert M; Francey, Thierry; Howard, Judith

    2012-04-15

    To evaluate the agreement of blood pressure measurements and hypertension scores obtained by use of 3 indirect arterial blood pressure measurement devices in hospitalized dogs. Design-Diagnostic test evaluation. 29 client-owned dogs. 5 to 7 consecutive blood pressure readings were obtained from each dog on each of 3 occasions with a Doppler ultrasonic flow detector, a standard oscillometric device (STO), and a high-definition oscillometric device (HDO). When the individual sets of 5 to 7 readings were evaluated, the coefficient of variation for systolic arterial blood pressure (SAP) exceeded 20% for 0% (Doppler), 11 % (STO), and 28% (HDO) of the sets of readings. After readings that exceeded a 20% coefficient of variation were discarded, repeatability was within 25 (Doppler), 37 (STO), and 39 (HDO) mm Hg for SAP. Correlation of mean values among the devices was between 0.47 and 0.63. Compared with Doppler readings, STO underestimated and HDO overestimated SAP. Limits of agreement between mean readings of any 2 devices were wide. With the hypertension scale used to score SAP, the intraclass correlation of scores was 0.48. Linear-weighted inter-rater reliability between scores was 0.40 (Doppler vs STO), 0.38 (Doppler vs HDO), and 0.29 (STO vs HDO). Results of this study suggested that no meaningful clinical comparison can be made between blood pressure readings obtained from the same dog with different indirect blood pressure measurement devices.

  15. The relationship between nasalance scores and nasality ratings obtained with equal appearing interval and direct magnitude estimation scaling methods.

    Science.gov (United States)

    Brancamp, Tami U; Lewis, Kerry E; Watterson, Thomas

    2010-11-01

    To assess the nasalance/nasality relationship and Nasometer test sensitivity and specificity when nasality ratings are obtained with both equal appearing interval (EAI) and direct magnitude estimation (DME) scaling procedures. To test the linearity of the relationship between nasality ratings obtained from different perceptual scales. STIMULI: Audio recordings of the Turtle Passage. Participants' nasalance scores and audio recordings were obtained simultaneously. A single judge rated the samples for nasality using both EAI and DME scaling procedures. Thirty-nine participants 3 to 17 years of age. Across participants, resonance ranged from normal to severely hypernasal. Nasalance scores and two nasality ratings. The magnitude of the correlation between nasalance scores and EAI ratings of nasality (r  =  .63) and between nasalance and DME ratings of nasality (r  =  .59) was not significantly different. Nasometer test sensitivity and specificity for EAI-rated nasality were .71 and .73, respectively. For DME-rated nasality, sensitivity and specificity were .62 and .70, respectively. Regression of EAI nasality ratings on DME nasality ratings did not depart significantly from linearity. No difference was found in the relationship between nasalance and nasality when nasality was rated using EAI as opposed to DME procedures. Nasometer test sensitivity and specificity were similar for EAI- and DME-rated nasality. A linear model accounted for the greatest proportion of explained variance in EAI and DME ratings. Consequently, clinicians should be able to obtain valid and reliable estimates of nasality using EAI or DME.

  16. Comparison of nasalance scores obtained with the Nasometer, the NasalView, and the OroNasal System.

    Science.gov (United States)

    Bressmann, Tim

    2005-07-01

    To compare nasalance scores obtained with the Nasometer, the NasalView, and the OroNasal System; evaluate test-retest reliability of the three systems; and explore whether three common text passages used for nasalance analysis could be shortened to a sentence each. Seventy-six adults with normal speech and hearing (mean age 26.5 years). Subjects read the complete Zoo Passage, Rainbow Passage, and Nasal Sentences. Mean nasalance magnitudes and mean nasalance distances were obtained with the three devices. The Nasometer had the lowest nasalance scores for the nonnasal Zoo Passage. The NasalView had the highest nasalance scores for the phonetically balanced Rainbow Passage. The OroNasal System had the lowest nasalance scores for the Nasal Sentences. The nasalance distance was largest for the Nasometer and smallest for the OroNasal System. Over 90% of the recordings were within 4% to 6% nasalance for most materials recorded with the Nasometer and the NasalView and within 7% to 9% for materials recorded with the OroNasal System. There were significant differences between the complete Zoo Passage and the Nasal Sentences and the individual sentences from these passages for the Nasometer and the OroNasal System. The three systems measure nasalance in different ways and provide nasalance scores that are not interchangeable. Test-retest variability for the Nasometer and the NasalView may be higher than previously reported. Individual sentences from the Zoo Passage and the Nasal Sentences do not provide nasalance scores that are equivalent to the complete passages.

  17. Correlation Between Wound Temperature Obtained With an Infrared Camera and Clinical Wound Bed Score in Venous Leg Ulcers.

    Science.gov (United States)

    Dini, Valentina; Salvo, Pietro; Janowska, Agata; Di Francesco, Fabio; Barbini, Alessandro; Romanelli, Marco

    2015-10-01

    The measurement of skin and wound bed temperature in chronic wounds may be a useful way to optimize the assessment and diagnosis of chronic wound infection. The aim of this clinical research trial was to correlate the wound bed score, validated by Falanga in 2006, to wound bed and perilesional skin temperature with an easy-to-use, handheld, noninvasive thermometer. In this study, the authors recruited 18 patients affected by venous insufficiency and lower leg ulcers. A total of 24 chronic wound bed and perilesional skin ulcers were assessed using an infrared camera (FLIR T620 Thermal Imager, FLIR Systems Boston, MA). At the same visit, an operator blinded to the thermal image results made a wound bed score to make a clinical evaluation of the lesion. The wound bed temperature range after dressing removal was between 31°C and 35°C, and the perilesional skin temperature range was between 31°C and 34°C. The wound bed score range was between 5-14 (14 patients > 10; 11 patients ≤ 10). The study data showed an increasing relationship between the wound bed score and the wound bed temperature according to several studies that have demonstrated 33°C is the critical temperature level required for normal cellular activity. The correlation between the wound bed score and the perilesional skin temperature is weaker compared to other measurements. The results obtained in this preliminary research suggest that this correlation is worth being further investigated with a larger dataset.

  18. Blood lipid profile and BMI-Z-score in adolescents with hyperuricemia.

    Science.gov (United States)

    Stelmach, M J; Wasilewska, N; Wicklund-Liland, L I; Wasilewska, A

    2015-06-01

    Numerous studies have demonstrated that elevated serum uric acid concentration (SUA) is correlated with lipid profile in hypertensive or obese patients. However, the relationship between serum uric acid levels and lipid profile in non-obese late adolescent population was not examined before. In this study we decided to assess the potential relationship between SUA and lipid profile, according to gender in adolescents with HU. The study group comprises 607 Polish adolescents (474 males, 133 females) with HU. Retrospective analysis included demographic, clinical, and laboratory data. Lipid profile was assessed including total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), total cholesterol to HDL-C ratio (TC/HDL-C). In the examined group 187/607 (31%) of teenagers were diagnosed with metabolic syndrome (MetS). Median BMI-Z-score was 1.11 Q1-Q3: (-0.02-2.03) and both females and males in the upper tertile of SUA had statistically significant higher BMI-Z-score. The males in the upper tertile of serum uric acid levels also had higher values of TG and lower of HDL-C. In females, we have not found significant differences in lipid profile. Multiple regression analyses indicated that male gender, BMI-Z-score, and presence of hypertension correlated significantly with serum uric acid concentration. In summary, the results of our study confirm higher prevalence of hyperuricemia in males when compared to females and a stronger association of HU with BMI-Z-score and lipid profile in male adolescents. Nevertheless, multiple regression does not confirm the independent association of SUA with lipid profile.

  19. Match score affects activity profile and skill performance in professional Australian Football players.

    Science.gov (United States)

    Sullivan, Courtney; Bilsborough, Johann C; Cianciosi, Michael; Hocking, Joel; Cordy, Justin; Coutts, Aaron J

    2014-05-01

    To examine the influence of quarter outcome and the margin of the score differential on both the physical activity profile and skill performance of players during professional Australian Football matches. Prospective, longitudinal. Physical activity profiles were assessed via microtechnology (Global Positioning System and accelerometer) from 40 professional AF players from the same team during 15 Australian Football League games. Skill performance measures (involvement and effectiveness) and player rank scores (Champion Data(©) Rank) were provided by a commercial statistical provider. The physical performance variables, skill involvements and individual player performance scores were expressed relative to playing time for each quarter. The influence of the quarter result (i.e. win vs. loss) and score margin (i.e. small: 19 points) on activity profile and skill involvements and skill efficiency performance of players were examined. Skill involvements (total disposals/min, long kicks/min, marks/min, running bounces/min and player rank/min) were greater in quarters won (all p14.5 km h(-1), HSR/min), sprints/min and peak speed were higher in losing quarters (all p<0.01). Smaller score margins were associated with increased physical activity (m/min, HSR/min, and body load/min, all p<0.05) and decreased skill efficiency (handball clangers/min and player rank/min, all p<0.05). Professional AF players are likely to have an increased physical activity profile and decreased skill involvement and proficiency when their team is less successful. Copyright © 2013 Sports Medicine Australia. Published by Elsevier Ltd. All rights reserved.

  20. ANTHROPOMETRIC PROFILE, BODY COMPOSITION AND VERTICAL JUMP SCORE IN BOXERS AND SWIMMERS

    Directory of Open Access Journals (Sweden)

    A. S. Roy

    2014-12-01

    Conclusion. Significant intergroup difference was found in the studied parameters. VJT scores obtained in all the groups were well comparable. Higher value of body %fat imposed the unfavourable effect towards achieving higher jumping height mainly in sedentary group. KEY WORDS: VJT, boxers, swimmers, %fat, LBM.

  1. Cross Racial Identity Scale (CRIS) scores and profiles in African American adolescents involved with the juvenile justice system.

    Science.gov (United States)

    Worrell, Frank C; Andretta, James R; Woodland, Malcolm H

    2014-10-01

    In this study, we examined the internal consistency and structural validity of Cross Racial Identity Scale (CRIS) scores in a sample of 477 African American adolescents who had been arrested in a city in the mid-Atlantic. Using cluster analysis, we also identified profiles of CRIS scores and compared adolescents with different profiles on Major Depressive Episode, Manic Episode, Generalized Anxiety Disorder, and Obsessive-Compulsive Disorder scores. Results indicated that CRIS subscale scores were reliable, and the 6-factor structure of the CRIS was supported. Five nigrescence profiles were identified: Miseducation-Pro-Black, Conflicted-Self-Hatred, Multiculturalist, Low Race Salience, and Conflicted-Anti-White. Individuals with Conflicted-Self-Hatred profiles reported significantly and meaningfully higher scores on the 4 syndromes than did their peers, and individuals with the Multiculturalist and Low Race Salience profiles reported the lowest scores. A greater percentage of individuals with Conflicted racial identity profiles had syndrome scores in the clinically significant range. The results of this study demonstrate that some of the nigrescence profiles found in college-age students generalize to adolescents. The implications of the findings for theory, research, and practice are discussed. PsycINFO Database Record (c) 2014 APA, all rights reserved.

  2. Metabolic profile of santa inês ewes whith low body condition score during peripartum

    Directory of Open Access Journals (Sweden)

    Nayara Resende Nasciutti

    2012-02-01

    Full Text Available The objective of this study was to analyse the variations in the metabolic profile of protein, energy enzyme and mineral of Santa Inês ewes with low body condition score (BCS during peripartum. Blood samples were collected from 12 animals by jugular venipuncture to determine the serum biochemical profiles of protein, energy, mineral and enzyme metabolisms. Samples were collected on the following days: days 28, 21, 14, and 7 before lambing, at birth and, at days 2, 4, 7, 14, 21, and 28 postpartum (dpp. The samples were centrifuged and the serum analysed by Automated-Analyser. There was no alteration of the BCS during the 28 dpp, between 0.6 and 2.1 ± 2.4 ± 0.5, and was considered, as lean. The values of the total serum protein, globulin, albumin, and albumin/globulin ratio were reduced effective from the period before birth until 28dpp. The values of beta-hydroxybutyrate, calcium, phosphorus and magnesium remained below those of reference values. The concentrations of alanin aminotransferase (ALT were decreased particularly during the weeks before delivery. It was concluded that Santa Inês sheep with low body condition score demonstrated a reduction in the metabolism of proteins, energy, mineral and enzyme during peripartum.

  3. Oncologic control obtained after radical prostatectomy in men with a pathological Gleason score ≥ 8: a single-center experience.

    Science.gov (United States)

    Audenet, François; Comperat, Eva; Seringe, Elise; Drouin, Sarah J; Richard, François; Cussenot, Olivier; Bitker, Marc-Olivier; Rouprêt, Morgan

    2011-01-01

    To assess the oncologic control afforded by radical prostatectomy (RP) in high-risk prostate cancers with a Gleason score ≥ 8. We performed a retrospective review of prostate cancer patients who underwent RP between 1995 and 2005 for prostate cancer and who had a pathologic Gleason score ≥ 8. Biochemical recurrence was defined as a single rise in PSA levels over 0.2 ng/ml after surgery. Overall, 64 patients were included and followed for a median time of 84.3 months. The mean age was 63 ± 5.2 years. The mean preoperative PSA was 11.9 ± 7.3 ng/ml (1.9-31), and 29 patients (46%) had a PSA > 10 ng/ml. The biopsy Gleason score was ≤ 7 for 49 patients (76.6%). After pathologic analysis, there were 25 (39%) stage pT2, 37 (58%) stage pT3, and 2 (3%) stage pT4 patients. Nine patients had lymph node involvement (14%). The surgical margins were positive in 25 patients (39%). In 51 patients, (80%) the Gleason score was underestimated by biopsies: 40 patients with a definitive score of Gleason 8 had a Gleason score of 6 or 7 on biopsies, while 11 patients with a Gleason score of 9 initially, had a Gleason score of 7 or 8. Twenty-seven patients underwent adjuvant treatment: external radiation therapy (n = 19), HRT (n = 3), or both (n = 5). During follow-up, 41 patients (64%) presented with a biochemical recurrence, and 11 (17%) died. The PSA-free survival rate at five year was 44%. RP remains a possible therapeutic option in certain cases of the high-risk cohort of patients with a Gleason score ≥ 8. However, patients should be warned that surgery might only be the first step of a multi-modal treatment approach. The modalities of adjuvant treatments and the right schedule to deliver it following RP still need to be defined. Copyright © 2011 Elsevier Inc. All rights reserved.

  4. Comparison of Temperature Measurements in the Middle Atmosphere by Satellite with Profiles Obtained by Meteorological Rockets

    Science.gov (United States)

    Goldberg, Richard A.; Schmidlin, Francis J.; Feofilov, Artem; Bedrick, M.; Rose, R. Lynn

    2012-01-01

    Measurements using the inflatable falling sphere technique have occasionally been used to obtain temperature results from density data and thereby provide comparison with temperature profiles obtained by satellite sounders in the mesosphere and stratosphere. To insure density measurements within narrow time frames and close in space, the inflatable falling sphere is launched within seconds of the nearly overhead satellite pass. Sphere measurements can be used to validate remotely measured temperatures but also have the advantage of measuring small-scale atmospheric features. Even so, with the dearth of remaining falling spheres available (the manufacture of these systems has been discontinued), it may be time to consider whether the remote measurements are mature enough to stand alone. Three field studies are considered, one in 2003 from Northern Sweden, and two in 2010 from the vicinity of Kwajalein Atoll in the South Pacific and from Barking Sands, Hawaii. All three sites are used to compare temperature retrievals between satellite and in situ falling spheres. The major satellite instruments employed are SABER, MLS, and AIRS. The comparisons indicate that remotely measured temperatures mimic the sphere temperature measurements quite well. The data also confirm that satellite retrievals, while not always at the exact location required for detailed studies in space and time, compare sufficiently well to be highly useful. Although the falling sphere will provide a measurement at a specific location and time, satellites only pass a given location daily or less frequently. This report reveals that averaged satellite measurements can provide temperatures and densities comparable to those obtained from the falling sphere, thereby providing a reliable measure of global temperature

  5. Determination of the meniscus shape of a negative ion beam from an experimentally obtained beam profile

    Science.gov (United States)

    Ichikawa, M.; Kojima, A.; Chitarin, G.; Agostinetti, P.; Aprile, D.; Baltador, C.; Barbisan, M.; Delogu, R.; Hiratsuka, J.; Marconato, N.; Nishikiori, R.; Pimazzoni, A.; Sartori, E.; Serianni, G.; Tobari, H.; Umeda, N.; Veltri, P.; Watanabe, K.; Yoshida, M.; Antoni, V.; Kashiwagi, M.

    2017-08-01

    In order to understand the physics mechanism of a negative ion extraction in negative ion sources, an emission surface of the negative ions around an aperture at a plasma grid, so-called a meniscus, has been analyzed by an inverse calculation of the negative ion trajectory in a two dimensional beam analysis code. In this method, the meniscus is defined as the final position of the negative ion trajectories which are inversely calculated from the measured beam profile to the plasma grid. In a case of the volume-produced negative ions, the calculated meniscus by the inverse calculation was similar to that obtained in conventional beam simulation codes for positive ion extractions such as BEAMORBT and SLACCAD. The negative ion current density was uniform along the meniscus. This indicates that the negative ions produced in the plasma are transported to the plasma grid uniformly as considered in the transportation of the positive ions. However, in a surface production case of negative ions, where the negative ions are generated near the plasma grid with lower work function by seeding cesium, the current density in the peripheral region of the meniscus close to the plasma grid surface was estimated to be 2 times larger than the center region, which suggested that the extraction process of the surface-produced negative ions was much different with that for the positive ions. Because this non-uniform profile of the current density made the meniscus shape strongly concave, the beam extracted from the peripheral region could have a large divergence angle, which might be one of origins of so-called beam halo. This is the first results of the determination of the meniscus based on the experiment, which is useful to improve the prediction of the meniscus shape and heat loads based on the beam trajectories including beam halo.

  6. Correlation of body mass index Z-scores with glucose and lipid profiles among overweight and obese children and adolescents.

    Science.gov (United States)

    Nogueira-de-Almeida, Carlos Alberto; Mello, Elza Daniel de

    2017-09-04

    To evaluate the prevalence of abnormalities in plasma lipid and glucose profiles among overweight and obese children and adolescents, and to assess the presence of a correlation between body mass index Z-scores and indicators of comorbidities related to both profiles. This was a multicenter cross-sectional study conducted at two outpatient clinics. The study included all 417 comers for the first visit from 2008 to 2012, aged between 7 and 18 years, with BMI above the Z-score +1. Anthropometry and blood sampling were obtained. The prevalence of dyslipidemias, hyperglycemia, and insulin resistance were evaluated, together with the correlations of these variables with the increase of Z-BMI. Dyslipidemia was observed in 43.4% of the boys and 66.1% of the girls, with no difference between genders. High glucose levels were detected in 6.2% of the individuals. Insulin resistance was present in 32.3% and 41.7% of the cases, with no statistical significance between boys and girls. Correlations between the Z-BMI were noted for triglycerides in the entire group and among girls; for HDL-c, only among girls; for glucose, a correlation was observed for the entire group, but not when stratified by gender. The indicators of insulin resistance were all correlated with Z-BMI, even when corrected for age. Overweight and obesity give origin to a high prevalence of dyslipidemia and insulin resistance. BMI Z-scores showed a weak positive correlation with glucose and triglyceride, and negative with HDL-c. In turn, the strongest positive correlation was found with insulin resistance indicators. Copyright © 2017 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda. All rights reserved.

  7. Assessment studies on the inversion of satellite to satellite electron content to obtain electron density profiles in the ionosphere

    CERN Document Server

    Hochegger, G P

    2000-01-01

    The electron content data, obtained by satellite-to-satellite occultations of radio signals can lead to height profiles of electron density by discrete inversion. Since there is no possibility to verify such profiles by means of other measurements (practically never measurements at the same time and same location) it was necessary to simulate occultation scenarios by means of an ionosphere model to obtain a large number of comparisons sufficient for investigations on a statistical basis. The obtained electron contents were inverted and compared with electron density height profiles, obtained with the same ionospheric model for the occultation point. The differences between these profiles were investigated (difference between the F2-peak maxima, the height of the maxima, the shape of the topside and bottom side ionosphere). Since simulations were done for chosen locations (250 randomly spread on the globe) for every month and every second hour and for two solar activity levels (HSA and LSA), a whole year was '...

  8. Derivative-free neural network for optimizing the scoring functions associated with dynamic programming of pairwise-profile alignment.

    Science.gov (United States)

    Yamada, Kazunori D

    2018-01-01

    A profile-comparison method with position-specific scoring matrix (PSSM) is among the most accurate alignment methods. Currently, cosine similarity and correlation coefficients are used as scoring functions of dynamic programming to calculate similarity between PSSMs. However, it is unclear whether these functions are optimal for profile alignment methods. By definition, these functions cannot capture nonlinear relationships between profiles. Therefore, we attempted to discover a novel scoring function, which was more suitable for the profile-comparison method than existing functions, using neural networks. Although neural networks required derivative-of-cost functions, the problem being addressed in this study lacked them. Therefore, we implemented a novel derivative-free neural network by combining a conventional neural network with an evolutionary strategy optimization method used as a solver. Using this novel neural network system, we optimized the scoring function to align remote sequence pairs. Our results showed that the pairwise-profile aligner using the novel scoring function significantly improved both alignment sensitivity and precision relative to aligners using existing functions. We developed and implemented a novel derivative-free neural network and aligner (Nepal) for optimizing sequence alignments. Nepal improved alignment quality by adapting to remote sequence alignments and increasing the expressiveness of similarity scores. Additionally, this novel scoring function can be realized using a simple matrix operation and easily incorporated into other aligners. Moreover our scoring function could potentially improve the performance of homology detection and/or multiple-sequence alignment of remote homologous sequences. The goal of the study was to provide a novel scoring function for profile alignment method and develop a novel learning system capable of addressing derivative-free problems. Our system is capable of optimizing the performance of other

  9. LIPID PROFILE OF CIRRHOTIC PATIENTS AND ITS ASSOCIATION WITH PROGNOSTIC SCORES: a cross-sectional study

    Directory of Open Access Journals (Sweden)

    Lílian BASSANI

    2015-09-01

    Full Text Available BackgroundIn cirrhosis the production of cholesterol and lipoproteins is altered.ObjectiveEvaluate the lipid profile by measuring total cholesterol, very low-density lipoprotein, low-density lipoprotein, high-density lipoprotein and triglyceride levels in patients with cirrhosis caused by alcoholism and/or hepatitis C virus infection and determine its association with Child-Pugh and MELD scores.MethodsCross-sectional retrospective study of patients treated at the outpatient clinic in Porto Alegre, Brazil, from 2006 to 2010.ResultsIn total, 314 records were reviewed, and 153 (48.7% met the inclusion criteria, of which 82 (53.6% had cirrhosis that was due to hepatitis C virus infection, 50 (32.7% were due to alcoholism, and 21 (13.7% were due to alcoholism and hepatitis C virus infection. The total cholesterol levels diminished with a Child-Pugh progression (P20 was associated with lower total cholesterol levels (<100mg/dL; P<0.001, very low-density lipoprotein (<16 mg/dL; P=0.006, and low-density lipoprotein (<70 mg/dL; P=0.003. Inverse and statistically significant correlations were observed between Child-Pugh and all the lipid fractions analyzed (P<0.001. The increase in MELD was inversely correlated with reduced levels intotal cholesterol (P<0.001, high-density lipoprotein (P<0.001, low-density lipoprotein (P<0.001, very low-density lipoprotein (P=0.030 and triglyceride (P=0.003.ConclusionA reduction in the lipid profile in patients with cirrhosis due to hepatitis C virus infection and/or alcoholism was significantly associated with the Child-Pugh and MELD prognostic markers. These results suggest that the lipid profile may be used as a tool to assist in evaluating liver disease.

  10. Seminal plasma protein profiles of ejaculates obtained by internal artificial vagina and electroejaculation in Brahman bulls.

    Science.gov (United States)

    Rego, J P A; Moura, A A; Nouwens, A S; McGowan, M R; Boe-Hansen, G B

    2015-09-01

    The present study was conducted to investigate if differences exist in the seminal plasma protein profile from mature Brahman bulls using two methods of semen collection: internal artificial vagina (IAV) and electroejaculation (EEJ). Semen was collected four times from three bulls on the same day and parameters were assessed immediately post-collection. Seminal plasma proteins were evaluated by 2-D fluorescence difference gel electrophoresis and identified by mass spectrometry. Semen volume was greater (P < 0.05) for EEJ (4.6 ± 0.35 mL) than for IAV (1.86 ± 0.24 mL) but sperm concentration was greater in IAV (1505 ± 189 × 10(6) sperm/mL) than in EEJ samples (344 ± 87 × 10(6) sperm/mL). Sperm motility and the percentage of normal sperm were not different between treatments. Total concentration of seminal plasma proteins was greater for samples collected by IAV as compared to EEJ (19.3 ± 0.9 compared with 13.0 ± 1.8 mg/mL, P < 0.05; respectively). Based on 2-D gels, 22 spots had a greater volume (P < 0.05) in gels derived from IAV samples, corresponding to 21 proteins identified as transferrin, albumin, epididymal secretory glutathione peroxidase, among others. Thirty-three spots, corresponding to 26 proteins, had a greater volume (P < 0.05) in gels derived from EEJ samples. These proteins were identified as spermadhesin-1, Bovine Sperm Protin 1, 3 and 5 isoforms, angiogenin-1, alpha-1B-glycoprotein, clusterin, nucleobindin-1, cathepsins, spermadhesin Z13, annexins, among others. Thus, proteins in greater amounts in samples obtained by IAV and EEJ were mainly of epididymal origin and accessory sex glands, respectively. Copyright © 2015 Elsevier B.V. All rights reserved.

  11. Assessment of Atmospheric Wet Profiles Obtained from COSMIC Radio Occultation Observations over China

    Directory of Open Access Journals (Sweden)

    Guirong Xu

    2017-10-01

    Full Text Available Atmosperic profiles derived from Constellation Observing System for Meteorology, Ionosphere, and Climate (COSMIC radio occultation (RO measurements make up for the lack of operational radiosonde soundings with a high spatiotemporal distribution, and their performance over China is assessed in this paper. COSMIC-retrieved atmospheric wet profiles from 2014 to 2015 are compared to the contemporaneous radiosonde profiles from 120 stations, and the vertical mean differences are used. The results show that the vertical mean biases of temperature, pressure and vapor pressure are −0.10 K, 0.69 hPa and −0.01 hPa, respectively, and that for refractivity is 0.17 N. Moreover, the temperature differences are positively correlated with station altitude, yet both the pressure and vapor pressure differences are negatively correlated with station latitude, as is the refractivity difference. The large temperature difference arising from the Qinghai-Tibet Plateau (QTP region may be associated with the complex topography of the area and the limitations in the background model used in the COSMIC profile retrieval. Furthermore, negative refractivity bias between COSMIC and radiosonde data occurs below 5 km and is large in wet southern China, with a value of less than 1%. This result may be related to more humid conditions and super-refraction.

  12. Iron ions distribution profile obtained by irradiating the silicon single crystal

    Science.gov (United States)

    Shemukhin, A. A.; Kozhemiako, A. V.; Balakshin, Y. V.; Chernysh, V. S.

    2017-11-01

    Iron ions with energies of 90 and 250 keV and the irradiation dose of 1016 ions/cm2 and xenon ions with energies of 100 keV and dose 7,7×1014 cm-2, 200 keV and dose 2,6 × 1014 cm-2 were implanted in the single crystal of silicon (110). The distribution profiles of implanted impurity, as well as the distribution profiles of the radiation defects in the crystal lattice, were studied by the Rutherford backscattering method in combination with channeling. The experimental results were compared with the results of simulations of binary collisions of the Monte Carlo method in the TRIM program. It is shown that the difference between the experimental data and the calculation program TRIM is more than 35% in all cases.

  13. Conversion of a molecular classifier obtained by gene expression profiling into a classifier based on real-time PCR: a prognosis predictor for gliomas

    Directory of Open Access Journals (Sweden)

    Mikuni Nobuhiro

    2010-11-01

    Full Text Available Abstract Background The advent of gene expression profiling was expected to dramatically improve cancer diagnosis. However, despite intensive efforts and several successful examples, the development of profile-based diagnostic systems remains a difficult task. In the present work, we established a method to convert molecular classifiers based on adaptor-tagged competitive PCR (ATAC-PCR (with a data format that is similar to that of microarrays into classifiers based on real-time PCR. Methods Previously, we constructed a prognosis predictor for glioma using gene expression data obtained by ATAC-PCR, a high-throughput reverse-transcription PCR technique. The analysis of gene expression data obtained by ATAC-PCR is similar to the analysis of data from two-colour microarrays. The prognosis predictor was a linear classifier based on the first principal component (PC1 score, a weighted summation of the expression values of 58 genes. In the present study, we employed the delta-delta Ct method for measurement by real-time PCR. The predictor was converted to a Ct value-based predictor using linear regression. Results We selected UBL5 as the reference gene from the group of genes with expression patterns that were most similar to the median expression level from the previous profiling study. The number of diagnostic genes was reduced to 27 without affecting the performance of the prognosis predictor. PC1 scores calculated from the data obtained by real-time PCR showed a high linear correlation (r = 0.94 with those obtained by ATAC-PCR. The correlation for individual gene expression patterns (r = 0.43 to 0.91 was smaller than for PC1 scores, suggesting that errors of measurement were likely cancelled out during the weighted summation of the expression values. The classification of a test set (n = 36 by the new predictor was more accurate than histopathological diagnosis (log rank p-values, 0.023 and 0.137, respectively for predicting prognosis. Conclusion

  14. Spatially matched in vivo and ex vivo MR metabolic profiles of prostate cancer - investigation of a correlation with Gleason score

    NARCIS (Netherlands)

    Selnaes, K.M.; Gribbestad, I.S.; Bertilsson, H.; Wright, A.; Angelsen, A.; Heerschap, A.; Tessem, M.B.

    2013-01-01

    MR metabolic profiling of the prostate is promising as an additional diagnostic approach to separate indolent from aggressive prostate cancer. The objective of this study was to assess the relationship between the Gleason score and the metabolic biomarker (choline + creatine + spermine)/citrate

  15. Correlation of scores on the Eysenck Personality Inventory with those on the Gordon Personal Profile and Inventory.

    Science.gov (United States)

    Kentle, R L

    1994-10-01

    Correlations of scores on the Eysenck Personality Inventory with those on the Gordon Personal Profile (for 160 university undergraduates) and with the Gordon Personal Inventory (for 260 undergraduates) showed that Eysenck and Eysenck's Extraversion and Neuroticism bear reasonably close correspondence to Gordon's Sociability and Emotional Stability.

  16. From drug response profiling to target addiction scoring in cancer cell models

    Directory of Open Access Journals (Sweden)

    Bhagwan Yadav

    2015-10-01

    Full Text Available Deconvoluting the molecular target signals behind observed drug response phenotypes is an important part of phenotype-based drug discovery and repurposing efforts. We demonstrate here how our network-based deconvolution approach, named target addiction score (TAS, provides insights into the functional importance of druggable protein targets in cell-based drug sensitivity testing experiments. Using cancer cell line profiling data sets, we constructed a functional classification across 107 cancer cell models, based on their common and unique target addiction signatures. The pan-cancer addiction correlations could not be explained by the tissue of origin, and only correlated in part with molecular and genomic signatures of the heterogeneous cancer cells. The TAS-based cancer cell classification was also shown to be robust to drug response data resampling, as well as predictive of the transcriptomic patterns in an independent set of cancer cells that shared similar addiction signatures with the 107 cancers. The critical protein targets identified by the integrated approach were also shown to have clinically relevant mutation frequencies in patients with various cancer subtypes, including not only well-established pan-cancer genes, such as PTEN tumor suppressor, but also a number of targets that are less frequently mutated in specific cancer types, including ABL1 oncoprotein in acute myeloid leukemia. An application to leukemia patient primary cell models demonstrated how the target deconvolution approach offers functional insights into patient-specific addiction patterns, such as those indicative of their receptor-type tyrosine-protein kinase FLT3 internal tandem duplication (FLT3-ITD status and co-addiction partners, which may lead to clinically actionable, personalized drug treatment developments. To promote its application to the future drug testing studies, we have made available an open-source implementation of the TAS calculation in the form

  17. Standard Test Method for Obtaining Char Density Profile of Ablative Materials by Machining and Weighing

    CERN Document Server

    American Society for Testing and Materials. Philadelphia

    1996-01-01

    1.1 This test method covers the determination of the char density profile of a charred ablator that can be used with the following limitations: 1.1.1 The local surface imperfections must be removed, and the char must be able to be machined off in a plane parallel to the char-virgin material interface before the density profiles can be determined. 1.1.2 The char must be strong enough to withstand the machining and handling techniques employed. 1.1.3 The material should have orderly density variations. The total thickness of the char and degradation zone must be larger than the machining thicknesses required. 1.2 The values stated in SI units are to be regarded as standard. No other units of measurement are included in this standard. 1.2.1 Exception—Certain inch-pound equivalent units are included in parentheses for information only. 1.3 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establis...

  18. Magnetic resonance metabolic profiling of breast cancer tissue obtained with core needle biopsy for predicting pathologic response to neoadjuvant chemotherapy.

    Directory of Open Access Journals (Sweden)

    Ji Soo Choi

    Full Text Available The purpose of this study was to determine whether metabolic profiling of core needle biopsy (CNB samples using high-resolution magic angle spinning (HR-MAS magnetic resonance spectroscopy (MRS could be used for predicting pathologic response to neoadjuvant chemotherapy (NAC in patients with locally advanced breast cancer. After institutional review board approval and informed consent were obtained, CNB tissue samples were collected from 37 malignant lesions in 37 patients before NAC treatment. The metabolic profiling of CNB samples were performed by HR-MAS MRS. Metabolic profiles were compared according to pathologic response to NAC using the Mann-Whitney test. Multivariate analysis was performed with orthogonal projections to latent structure-discriminant analysis (OPLS-DA. Various metabolites including choline-containing compounds were identified and quantified by HR-MAS MRS in all 37 breast cancer tissue samples obtained by CNB. In univariate analysis, the metabolite concentrations and metabolic ratios of CNB samples obtained with HR-MAS MRS were not significantly different between different pathologic response groups. However, there was a trend of lower levels of phosphocholine/creatine ratio and choline-containing metabolite concentrations in the pathologic complete response group compared to the non-pathologic complete response group. In multivariate analysis, the OPLS-DA models built with HR-MAS MR metabolic profiles showed visible discrimination between the pathologic response groups. This study showed OPLS-DA multivariate analysis using metabolic profiles of pretreatment CNB samples assessed by HR- MAS MRS may be used to predict pathologic response before NAC, although we did not identify the metabolite showing statistical significance in univariate analysis. Therefore, our preliminary results raise the necessity of further study on HR-MAS MR metabolic profiling of CNB samples for a large number of cancers.

  19. Breast cancer: determining the genetic profile from ultrasound-guided percutaneous biopsy specimens obtained during the diagnostic workups.

    Science.gov (United States)

    López Ruiz, J A; Zabalza Estévez, I; Mieza Arana, J A

    2016-01-01

    To evaluate the possibility of determining the genetic profile of primary malignant tumors of the breast from specimens obtained by ultrasound-guided percutaneous biopsies during the diagnostic imaging workup. This is a retrospective study in 13 consecutive patients diagnosed with invasive breast cancer by B-mode ultrasound-guided 12 G core needle biopsy. After clinical indication, the pathologist decided whether the paraffin block specimens seemed suitable (on the basis of tumor size, validity of the sample, and percentage of tumor cells) before sending them for genetic analysis with the MammaPrint® platform. The size of the tumors on ultrasound ranged from 0.6cm to 5cm. In 11 patients the preserved specimen was considered valid and suitable for use in determining the genetic profile. In 1 patient (with a 1cm tumor) the pathologist decided that it was necessary to repeat the core biopsy to obtain additional samples. In 1 patient (with a 5cm tumor) the specimen was not considered valid by the genetic laboratory. The percentage of tumor cells in the samples ranged from 60% to 70%. In 11/13 cases (84.62%) it was possible to do the genetic analysis on the previously diagnosed samples. In most cases, regardless of tumor size, it is possible to obtain the genetic profile from tissue specimens obtained with ultrasound-guided 12 G core biopsy preserved in paraffin blocks. Copyright © 2015 SERAM. Published by Elsevier España, S.L.U. All rights reserved.

  20. Dataset on metabolomics profile of acute leukemia blood obtained by the NMR methods

    OpenAIRE

    Bogaychuk, Alexander; Zyubin, Andrey; Lavrova, Anastasiya; Kupriyanova, Galina; Babak, Svetlana; Dambieva, Mariya; Demin, Maksim; Borisova, Anastasiya; Opryshko, Nikita

    2017-01-01

    This article contains NMR (nuclear magnetic resonance) experimental data, obtained by the NMR Varian 400?MHz spectrometer (USA) which can be used for the metabolites identification in human blood. Data include analyzed NMR spectra of plasma proteins extracted from human blood of 24 patients (0?5 years old) with the confirmed acute leukemia diagnosis. Data can provide information about metabolites and their concentration in blood.

  1. Dataset on metabolomics profile of acute leukemia blood obtained by the NMR methods.

    Science.gov (United States)

    Bogaychuk, Alexander; Zyubin, Andrey; Lavrova, Anastasiya; Kupriyanova, Galina; Babak, Svetlana; Dambieva, Mariya; Demin, Maksim; Borisova, Anastasiya; Opryshko, Nikita

    2017-04-01

    This article contains NMR (nuclear magnetic resonance) experimental data, obtained by the NMR Varian 400 MHz spectrometer (USA) which can be used for the metabolites identification in human blood. Data include analyzed NMR spectra of plasma proteins extracted from human blood of 24 patients (0-5 years old) with the confirmed acute leukemia diagnosis. Data can provide information about metabolites and their concentration in blood.

  2. Dataset on metabolomics profile of acute leukemia blood obtained by the NMR methods

    Directory of Open Access Journals (Sweden)

    Alexander Bogaychuk

    2017-04-01

    Full Text Available This article contains NMR (nuclear magnetic resonance experimental data, obtained by the NMR Varian 400 MHz spectrometer (USA which can be used for the metabolites identification in human blood. Data include analyzed NMR spectra of plasma proteins extracted from human blood of 24 patients (0–5 years old with the confirmed acute leukemia diagnosis. Data can provide information about metabolites and their concentration in blood.

  3. IHC Profiler: an open source plugin for the quantitative evaluation and automated scoring of immunohistochemistry images of human tissue samples.

    Directory of Open Access Journals (Sweden)

    Frency Varghese

    Full Text Available In anatomic pathology, immunohistochemistry (IHC serves as a diagnostic and prognostic method for identification of disease markers in tissue samples that directly influences classification and grading the disease, influencing patient management. However, till today over most of the world, pathological analysis of tissue samples remained a time-consuming and subjective procedure, wherein the intensity of antibody staining is manually judged and thus scoring decision is directly influenced by visual bias. This instigated us to design a simple method of automated digital IHC image analysis algorithm for an unbiased, quantitative assessment of antibody staining intensity in tissue sections. As a first step, we adopted the spectral deconvolution method of DAB/hematoxylin color spectra by using optimized optical density vectors of the color deconvolution plugin for proper separation of the DAB color spectra. Then the DAB stained image is displayed in a new window wherein it undergoes pixel-by-pixel analysis, and displays the full profile along with its scoring decision. Based on the mathematical formula conceptualized, the algorithm is thoroughly tested by analyzing scores assigned to thousands (n = 1703 of DAB stained IHC images including sample images taken from human protein atlas web resource. The IHC Profiler plugin developed is compatible with the open resource digital image analysis software, ImageJ, which creates a pixel-by-pixel analysis profile of a digital IHC image and further assigns a score in a four tier system. A comparison study between manual pathological analysis and IHC Profiler resolved in a match of 88.6% (P<0.0001, CI = 95%. This new tool developed for clinical histopathological sample analysis can be adopted globally for scoring most protein targets where the marker protein expression is of cytoplasmic and/or nuclear type. We foresee that this method will minimize the problem of inter-observer variations across labs and

  4. IHC Profiler: an open source plugin for the quantitative evaluation and automated scoring of immunohistochemistry images of human tissue samples.

    Science.gov (United States)

    Varghese, Frency; Bukhari, Amirali B; Malhotra, Renu; De, Abhijit

    2014-01-01

    In anatomic pathology, immunohistochemistry (IHC) serves as a diagnostic and prognostic method for identification of disease markers in tissue samples that directly influences classification and grading the disease, influencing patient management. However, till today over most of the world, pathological analysis of tissue samples remained a time-consuming and subjective procedure, wherein the intensity of antibody staining is manually judged and thus scoring decision is directly influenced by visual bias. This instigated us to design a simple method of automated digital IHC image analysis algorithm for an unbiased, quantitative assessment of antibody staining intensity in tissue sections. As a first step, we adopted the spectral deconvolution method of DAB/hematoxylin color spectra by using optimized optical density vectors of the color deconvolution plugin for proper separation of the DAB color spectra. Then the DAB stained image is displayed in a new window wherein it undergoes pixel-by-pixel analysis, and displays the full profile along with its scoring decision. Based on the mathematical formula conceptualized, the algorithm is thoroughly tested by analyzing scores assigned to thousands (n = 1703) of DAB stained IHC images including sample images taken from human protein atlas web resource. The IHC Profiler plugin developed is compatible with the open resource digital image analysis software, ImageJ, which creates a pixel-by-pixel analysis profile of a digital IHC image and further assigns a score in a four tier system. A comparison study between manual pathological analysis and IHC Profiler resolved in a match of 88.6% (P<0.0001, CI = 95%). This new tool developed for clinical histopathological sample analysis can be adopted globally for scoring most protein targets where the marker protein expression is of cytoplasmic and/or nuclear type. We foresee that this method will minimize the problem of inter-observer variations across labs and further help in

  5. Association of MCAT scores obtained with standard vs extra administration time with medical school admission, medical student performance, and time to graduation.

    Science.gov (United States)

    Searcy, Cynthia A; Dowd, Keith W; Hughes, Michael G; Baldwin, Sean; Pigg, Trey

    2015-06-09

    Individuals with documented disabilities may receive accommodations on the Medical College Admission Test (MCAT). Whether such accommodations are associated with MCAT scores, medical school admission, and medical school performance is unclear. To determine the comparability of MCAT scores obtained with standard vs extra administration time with respect to likelihood of acceptance to medical school and future medical student performance. Retrospective cohort study of applicants to US medical schools for the 2011-2013 entering classes who reported MCAT scores obtained with standard time (n = 133,962) vs extra time (n = 435), and of students who matriculated in US medical schools from 2000-2004 who reported MCAT scores obtained with standard time (n = 76,262) vs extra time (n = 449). Standard or extra administration time during MCAT. Primary outcome measures were acceptance rates at US medical schools and graduation rates within 4 or 5 years after matriculation. Secondary outcome measures were pass rates on the United States Medical Licensing Examination (USMLE) Step examinations and graduation rates within 6 to 8 years after matriculation. Acceptance rates were not significantly different for applicants who had MCAT scores obtained with standard vs extra time (44.5% [59,585/133,962] vs 43.9% [191/435]; difference, 0.6% [95% CI, -4.1 to 5.3]). Students who tested with extra time passed the Step examinations on first attempt at significantly lower rates (Step 1, 82.1% [344/419] vs 94.0% [70,188/74,668]; difference, 11.9% [95% CI, 9.6% to 14.2%]; Step 2 CK, 85.5% [349/408] vs 95.4% [70,476/73,866]; difference, 9.9% [95% CI, 7.8% to 11.9%]; Step 2 CS, 92.0% [288/313] vs 97.0% [60,039/61,882]; difference, 5.0% [95% CI, 3.1% to 6.9%]). They also graduated from medical school at significantly lower rates at different times (4 years, 67.2% [285/424] vs 86.1% [60,547/70,305]; difference, 18.9% [95% CI, 15.6% to 22.2%]; 5 years, 81.6% [346/424] vs 94.4% [66

  6. Quality and Trace Element Profile of Tunisian Olive Oils Obtained from Plants Irrigated with Treated Wastewater

    Directory of Open Access Journals (Sweden)

    Cinzia Benincasa

    2012-01-01

    Full Text Available In the present work the use of treated wastewater (TWW to irrigate olive plants was monitored. This type of water is characterized by high salinity and retains a substantial amount of trace elements, organic and metallic compounds that can be transferred into the soil and into the plants and fruits. In order to evaluate the impact of TWW on the overall quality of the oils, the time of contact of the olives with the soil has been taken into account. Multi-element data were obtained using ICP-MS. Nineteen elements (Li, B, Na, Mg, Al, K, Ca, Sc, Cr, Mn, Fe, Co, Ni, Cu, Zn, Sr, Mo, Ba and La were submitted for statistical analysis. Using analysis of variance, linear discriminant analysis and principal component analysis it was possible to differentiate between oils produced from different batches of olives whose plants received different types of water. Also, the results showed that there was correlation between the elemental and mineral composition of the water used to irrigate the olive plots and the elemental and mineral composition of the oils.

  7. Hemorheological disturbances correlate with the lipid profile but not with the NCEP-ATPIII score of the metabolic syndrome.

    Science.gov (United States)

    Aloulou, Ikram; Varlet-Marie, Emmanuelle; Mercier, Jacques; Brun, Jean-Frédéric

    2006-01-01

    The metabolic syndrome, which is associated with an high risk for diabetes and atherothrombosis, is associated with hemorheologic abnormalities. These abnormalities seem more and more to be explained by its various symptoms than by insulin resistance which represents theoretically the core of the syndrome. In this study we aimed at defining the specific hemorheologic profile of insulin resistance and hyperinsulinemia by separating a sample of 90 subjects into 4 subgroups according to the clinical score "NCEP-ATPIII" which is the best recognized standardized definition of the syndrome. Results show no significant changes of blood rheology across classes of NCEP score despite a borderline rank correlation between RBC aggregability "M1" and the score. Whole blood viscosity was mostly correlated to HDL-cholesterol (r = -0.353, p = 0.007) and triglycerides (r = 0.574, p = 0.0001). Plasma viscosity was correlated with total cholesterol (r = 0.3359, p = 0.02) and with LDL-cholesterol (r = 0.357, p = 0.03). Red blood cell rigidity "Tk" was negatively correlated to HDL-cholesterol (r = -0.430, p = 0.007). Aggregability "M" was correlated to total cholesterol (r = 0.356, p = 0.01) and "M1" to HDL-cholesterol (r = -0.406, p = 0.006). Thus, despite previously described correlations with glucose disposal parameters, the hyperviscosity syndrome of the metabolic syndrome is not proportional to its clinical scoring and is strongly dependent upon the lipid profile.

  8. The protein profile of Theobroma cacao L. seeds as obtained by matrix-assisted laser desorption/ionization mass spectrometry.

    Science.gov (United States)

    Bertazzo, Antonella; Agnolin, Fabio; Comai, Stefano; Zancato, Mirella; Costa, Carlo V L; Seraglia, Roberta; Traldi, Pietro

    2011-07-30

    The water-soluble protein profile of the seeds of green, red, and yellow Theobroma cacao L. fruits has been determined by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-ToF-MS). The seeds were powdered under liquid nitrogen and defatted. The residues were dialyzed and lyophilized. The obtained samples were suspended in the matrix solution of sinapinic acid. The obtained MALDI mass spectra showed the presence of a wide number of proteins with molecular weight ranging from 8000 to 13,000 Da and a cluster of peaks centered at 21,000 Da that were attributed to albumin. The abundance of this peak was found to depend on the different portion of the seed (husk, apical and cortical parts); however, the MALDI mass spectra obtained from the different varieties of cocoa were practically superimposable. Changes in the protein profiles were also observed after the cocoa seeds were treated by fermentation and roasting, which are processes usually employed for the commercial production of cocoa. Copyright © 2011 John Wiley & Sons, Ltd.

  9. Genetic risk scores link body fat distribution with specific cardiometabolic profiles

    DEFF Research Database (Denmark)

    Svendstrup, Mathilde; Sandholt, Camilla H; Andersson Galijatovic, Ehm Astrid

    2016-01-01

    OBJECTIVE: Forty-nine known single nucleotide polymorphisms (SNPs) associating with body mass index (BMI)-adjusted waist-hip-ratio (WHR) (WHRadjBMI) were recently suggested to cluster into three groups with different associations to cardiometabolic traits. Genetic risk scores of the clusters on t...

  10. Effects of nutrient profiling and price changes based on NuVal® scores on food purchasing in an online experimental supermarket.

    Science.gov (United States)

    Epstein, Leonard H; Finkelstein, Eric A; Katz, David L; Jankowiak, Noelle; Pudlewski, Corrin; Paluch, Rocco A

    2016-08-01

    The goal of the present study was to apply experimental economic methods in an online supermarket to examine the effects of nutrient profiling, and differential pricing based on the nutrient profile, on the overall diet quality, energy and macronutrients of the foods purchased, and diet cost. Participants were provided nutrient profiling scores or price adjustments based on nutrient profile scores while completing a hypothetical grocery shopping task. Prices of foods in the top 20 % of nutrient profiling scores were reduced (subsidized) by 25 % while those in the bottom 20 % of scores were increased (taxed) by 25 %. We evaluated the independent and interactive effects of nutrient profiling or price adjustments on overall diet quality of foods purchased as assessed by the NuVal® score, energy and macronutrients purchased and diet cost in a 2×2 factorial design. A large (>10 000 food items) online experimental supermarket in the USA. Seven hundred and eighty-one women. Providing nutrient profiling scores improved overall diet quality of foods purchased. Price changes were associated with an increase in protein purchased, an increase in energy cost, and reduced carbohydrate and protein costs. Price changes and nutrient profiling combined were associated with no unique benefits beyond price changes or nutrient profiling alone. Providing nutrient profile score increased overall NuVal® score without a reduction in energy purchased. Combining nutrient profiling and price changes did not show an overall benefit to diet quality and may be less useful than nutrient profiling alone to consumers who want to increase overall diet quality of foods purchased.

  11. Cardiovascular profile score as a predictor of acute intrapartum non-reassuring fetal status in infants with congenital heart defects.

    Science.gov (United States)

    Miyoshi, Takekazu; Katsuragi, Shinji; Neki, Reiko; Kurosaki, Ken-Ichi; Shiraishi, Isao; Nakai, Michikazu; Nishimura, Kunihiro; Yoshimatsu, Jun; Ikeda, Tomoaki

    2017-12-01

    To investigate the predictive factors of urgent cesarean delivery (CD) due to acute intrapartum non-reassuring fetal status (NRFS) in infants with congenital heart defects (CHDs). This was a retrospective review of 199 singletons prenatally diagnosed with a CHD and for whom vaginal delivery was attempted in our institution between 2007 and 2014. A cardiovascular profile (CVP) score was used to assess fetal heart failure. The number of urgent CDs due to NRFS was 37 (18.6%). Fetuses with a CVP score ≤7 were significantly more likely to require urgent CD due to NRFS than those with a CVP score ≥8 (p heart defects or biventricular cyanotic heart defects had a significantly higher frequency of urgent CD due to NRFS than those with other types of CHD (p = 0.017). Multivariate analysis showed that a CVP score ≤7, a birth weight heart failure, low birth weight, and primipara status were revealed to be independent predictors of urgent CD due to acute intrapartum NRFS in CHD infants. The CVP score may be a useful echocardiographic marker in perinatal management planning.

  12. Development of a Traumatic Brain Injury Assessment Score using Novel Biomarkers Discovered Through Autoimmune Profiling

    Science.gov (United States)

    2014-08-15

    1490; author reply 1492-1493. 25. Ross SA, Cunningham RT, Johnston CF, Rowlands BJ. Neuron-specific enolase as an aid to outcome prediction in head...2008;197(2):128-139. 50. Ring RH, Alder J, Fennell M, Kouranova E, Black IB, Thakker-Varia S. Transcriptional profiling of brain-derived-neurotrophic

  13. Use of fat mass and fat free mass standard deviation scores obtained using simple measurement methods in healthy children and patients: comparison with the reference 4-component model.

    Science.gov (United States)

    Atherton, Rachel R; Williams, Jane E; Wells, Jonathan C K; Fewtrell, Mary S

    2013-01-01

    Clinical application of body composition (BC) measurements for individual children has been limited by lack of appropriate reference data. (1) To compare fat mass (FM) and fat free mass (FFM) standard deviation scores (SDS) generated using new body composition reference data and obtained using simple measurement methods in healthy children and patients with those obtained using the reference 4-component (4-C) model; (2) To determine the extent to which scores from simple methods agree with those from the 4-C model in identification of abnormal body composition. FM SDS were calculated for 4-C model, dual-energy X-ray absorptiometry (DXA; GE Lunar Prodigy), BMI and skinfold thicknesses (SFT); and FFM SDS for 4CM, DXA and bioelectrical impedance analysis (BIA; height(2)/Z)) in 927 subjects aged 3.8-22.0 y (211 healthy, 716 patients). DXA was the most accurate method for both FM and FFM SDS in healthy subjects and patients (mean bias (limits of agreement) FM SDS 0.03 (± 0.62); FFM SDS -0.04 (± 0.72)), and provided best agreement with the 4-C model in identifying abnormal BC (SDS ≤-2 or ≥ 2). BMI and SFTs were reasonable predictors of abnormal FM SDS, but poor in providing an absolute value. BIA was comparable to DXA for FFM SDS and in identifying abnormal subjects. DXA may be used both for research and clinically to determine FM and FFM SDS. BIA may be used to assess FFM SDS in place of DXA. BMI and SFTs can be used to measure adiposity for groups but not individuals. The performance of simpler techniques in monitoring longitudinal BC changes requires investigation. Ultimately, the most appropriate method should be determined by its predictive value for clinical outcome.

  14. Metabolomics profiling of pre-and post-anesthesia plasma samples of colorectal patients obtained via Ficoll separation.

    Science.gov (United States)

    Ghini, Veronica; Unger, Florian T; Tenori, Leonardo; Turano, Paola; Juhl, Hartmut; David, Kerstin A

    2015-01-01

    (1)H NMR spectroscopy was used to investigate the metabolic consequences of general anesthesia in the plasma of two groups of patients with diagnosis for non-metastatic colorectal cancer and metastatic colorectal cancer with liver-metastasis, respectively. Patients were treated with etomidate or propofol, two frequently used sedation agents. Plasma samples were obtained via Ficoll separation. Here, we demonstrated that this procedure introduces a number of limitations for NMR-based metabolomics studies, due to the appearance of spurious signals. Nevertheless, the comparison of the (1)H NMR metabolomic profiles of patients treated with etomidate or propofol at equipotent dose ranges was still feasible and proved that both agents significantly decrease the plasma levels of several NMR-detectable metabolites. Consequently, samples collected during anesthesia are not suitable for metabolic profiling studies aimed at patient stratification, because interpersonal variability are reduced by the overall depression of metabolites levels. On the other hand, this study showed that plasma metabolomics could represent a valuable tool to monitor the effect of different sedation agents and/or the individual metabolic response to anesthesia, providing hints for an appropriate tuning of personalized sedation procedures. In our reference groups, the metabolomic signatures were slightly different in patients anesthetized with etomidate versus propofol. The importance of standardized collection procedures and availability of exhaustive metadata of the experimental design for the accurate evaluation of the significance of the observed changes in metabolites levels are critically discussed.

  15. SERUM LIPID PROFILE OF SPAYED AND NON-SPAYED FEMALE DOGS ASSOCIATED WITH THE BODY CONDITION SCORE

    Directory of Open Access Journals (Sweden)

    Patricia Almeida Ferreira

    2015-04-01

    Full Text Available Neutering females may be associated to weight gain in dogs. In order to diagnose possible alterations, such as diabetes and hyperlipidemias, laboratory assessment of carbohydrate and lipid metabolism is important. The aim of this study was to verify glycemia and serum lipid profile in non-spayed and spayed female dogs, and associate these results with the body condition score. Thirty-two spayed (n=16 and non-spayed (n=16 female dogs had their blood collected for biochemical analysis, and were classified as to their body condition score (BCS. Nine had normal BCS, 10 were overweight, and 13 were obese. Little difference was observed among spayed and non-spayed dogs. Glycemia of spayed canine females is higher than that of non-spayed dogs, regardless of the body condition score. Likewise, total cholesterol levels are higher in non-spayed females. The HDL is higher in non-spayed obese dogs than in spayed dogs with the same body condition, this parameter did not differ in other weight groups. Contrary to what happens in post-menopausal women, spaying dogs does not seem to have such a strong effect on the metabolic parameters assessed. This study revealed unique results, where neither spaying nor weight group had a strong association with metabolic alterations.

  16. Antioxidant activity, cytotoxic activity and metabolic profiling of juices obtained from saffron (Crocus sativus L.) floral by-products.

    Science.gov (United States)

    Tuberoso, Carlo I G; Rosa, Antonella; Montoro, Paola; Fenu, Maurizio Antonio; Pizza, Cosimo

    2016-05-15

    Juices obtained from cold-pressed saffron (Crocus sativus L.) floral by-products were evaluated as a potential source of compounds with antioxidant and cytotoxic activities. Floral by-products were split in two batches for extraction 24 and 48h after flower harvesting, respectively. The in vitro anti-oxidant activity of these extracts was tested using the FRAP and DPPH assays, and two biological models of lipid oxidation (activity in preventing cholesterol degradation and protection against Cu(2+)-mediated degradation of the liposomal unsaturated fatty acids). The cytotoxic activity was evaluated using the MTT assay. The results show that extracts obtained 48h post-harvest contained higher levels of total polar phenols and had the highest antioxidant activity in all of the performed assays. The LC-DAD and LC-ESI-(HR)MS(n) metabolic profiles showed high levels of kaempferol derivatives and anthocyanins. This study suggests that juices from saffron floral by-products could potentially be used to develop new products for the food and health industry. Copyright © 2015 Elsevier Ltd. All rights reserved.

  17. Transcriptome profiling of sheep granulosa cells and oocytes during early follicular development obtained by Laser Capture Microdissection

    Directory of Open Access Journals (Sweden)

    Bonnet Agnes

    2011-08-01

    Full Text Available Abstract Background Successful achievement of early folliculogenesis is crucial for female reproductive function. The process is finely regulated by cell-cell interactions and by the coordinated expression of genes in both the oocyte and in granulosa cells. Despite many studies, little is known about the cell-specific gene expression driving early folliculogenesis. The very small size of these follicles and the mixture of types of follicles within the developing ovary make the experimental study of isolated follicular components very difficult. The recently developed laser capture microdissection (LCM technique coupled with microarray experiments is a promising way to address the molecular profile of pure cell populations. However, one main challenge was to preserve the RNA quality during the isolation of single cells or groups of cells and also to obtain sufficient amounts of RNA. Using a new LCM method, we describe here the separate expression profiles of oocytes and follicular cells during the first stages of sheep folliculogenesis. Results We developed a new tissue fixation protocol ensuring efficient single cell capture and RNA integrity during the microdissection procedure. Enrichment in specific cell types was controlled by qRT-PCR analysis of known genes: six oocyte-specific genes (SOHLH2, MAEL, MATER, VASA, GDF9, BMP15 and three granulosa cell-specific genes (KL, GATA4, AMH. A global gene expression profile for each follicular compartment during early developmental stages was identified here for the first time, using a bovine Affymetrix chip. Most notably, the granulosa cell dataset is unique to date. The comparison of oocyte vs. follicular cell transcriptomes revealed 1050 transcripts specific to the granulosa cell and 759 specific to the oocyte. Functional analyses allowed the characterization of the three main cellular events involved in early folliculogenesis and confirmed the relevance and potential of LCM-derived RNA. Conclusions

  18. A comparison of the Sensory Profile scores of children with autism and an age- and gender-matched sample.

    Science.gov (United States)

    Brockevelt, Barbara L; Nissen, Ranelle; Schweinle, William E; Kurtz, Eric; Larson, Kyle J

    2013-11-01

    The Centers for Disease Control and Prevention (CDC) reports that autism spectrum disorder (ASD) affects one in 88 children in the United States. The American Psychiatric Association's Diagnostic and Statistical Manual, Text Revision (DSM-IV-TR) defines ASD as a pervasive neurodevelopmental disorder characterized by qualitative impairment in communication and social interaction, and restricted, repetitive and stereotyped behavior patterns. The purpose of this study was to determine whether children with autism differ in their response to sensory input relative to typically developing age- and gender-matched peers. The Sensory Profile (SP) is a 125-item caregiver questionnaire designed to measure a child's ability to process sensory information and to profile the effect of sensory processing on daily life activity. The results of the SP of 21 participants with autism ages 3 to 9 years were compared with an age- and gender-matched sample of typically developing children. Significant differences were found across all four SP quadrants (Registration, Seeking, Sensitivity, and Avoiding) as well as eight of the nine SP factor scores. This study adds to the evidence indicating that children with autism process and respond to sensory input differently than typically-developing peers. The findings from this study support previous research findings that sensory processing differences exist between children with ASD and their typically-developing peers, as measured by the SP.

  19. Evaluation of the hygienogram scores and related data obtained after cleaning and disinfection of poultry houses in Flanders during the period 2007 to 2014.

    Science.gov (United States)

    Maertens, H; De Reu, K; Van Weyenberg, S; Van Coillie, E; Meyer, E; Van Meirhaeghe, H; Van Immerseel, F; Vandenbroucke, V; Vanrobaeys, M; Dewulf, J

    2018-02-01

    Cleaning and disinfection (C&D) of poultry houses is an essential aspect in farm hygiene management. Adequate performance of the different steps of a C&D protocol and the use of suitable products are key to prevent and control zoonoses and animal diseases. Hygiene monitoring on total aerobic flora through sampling with agar contact plates at different locations of the poultry house results in a hygienogram score that is used to evaluate the proper execution of C&D.This study analyzed the hygienogram scores of 19,739 poultry flocks in Flanders after C&D. Data relating to the C&D protocol, i.e., year, season, husbandry system, production type, cleaning product, sampler, active components of the disinfectant, disinfection time, disinfection temperature, and disinfection responsible, were collected.The average hygienogram score decreased significantly over time, suggesting a general improvement between 2007 and 2014. Differences in scores were found among the husbandry systems, with the barn/aviary system having a significantly better hygienogram score compared to the floor house, furnished cage, and battery. Significantly better scores also were found when a cleaning product was used in the C&D protocol. Disinfection with a peracetic acid and hydrogen peroxide combination or formaldehyde gave the best scores. In addition, C&D protocols using ≥2 different disinfectants showed improved results compared to the use of one single disinfectant. Finally, disinfection applied by a specialist contractor resulted in a better score compared to disinfection by the farmer.In conclusion, analysis of the hygienogram scores and related data allowed identifying several factors, resulting in an improvement, which may reduce the total bacterial load in poultry stables and, consequently, the number of zoonotic and pathogenic micro-organisms. © 2017 Poultry Science Association Inc.

  20. Fat characteristics and fatty acid profile of sea cucumbers (Holothuria Scabra obtained from the coasts of the Bushehr province -Iran

    Directory of Open Access Journals (Sweden)

    Najmeh Jadavi

    2015-11-01

    Full Text Available Background: Sea cucumbers are belonging to echinoderms and one of the important members of the food chain in temperate ecosystems and tropical coral reefs. The medicinal and nutritional uses of these invertebrates are primordial and are important as ecological, biological and economic properties. Holothuria Scabra, as one of the most valuable commercial species of sea cucumber in the world, is the dominant species in many Persian Gulf coasts such as the Bushehr province coasts. Conspicuous characteristics such as the use of inexpensive foods in their culture, the rather rapid, easy and low cost growth and reproduction, the possibility of culture with other fish, reduce the organic substrate in pools, the broad tolerance in water factors changes such as salinity and temperature it has selected them to culture.It seems they are containing the significant amounts of nutrients, especially appreciated fatty acids. Therefore, the aims of the current study are determination of total fat content, quality and quantity evaluations of some physicochemical parameters such as acid value (AV, peroxide value (PV, and refractive index (RI as well as, identify the profile of fatty acids in the fat. Materials & Methods: In this study, after collecting the 36 samples of sea cucumbers from the coasts of the bushehr province, sample preparation, and extraction of fat, their fatty acids profile were analyzed using gas chromatography with flame ionization detector (GC-FID. Results: The peroxide and the acid values were 0.62±0.0435 and 0.7553±0.0034. The optical refractive index of the oil was 1467 at 26°C, and total fat was also 2%. Among 19 identified fatty acids obtained from the GC analysis of Holothuria Scabra oil, fatty acids: heneicosanoic acid, linoleic acid, palimitic acid, stearic acid, linoleic acid, and Meristic acid, with respectively amounts of 40.81%, 27.5%, 15.24%, 4.73%, 4.46% and 2.38% had the highest values, and other fatty acids were negligible

  1. Comparative analysis of gas production profiles obtained with buffalo and sheep ruminal fluid as the source of inoculum

    NARCIS (Netherlands)

    Calabrò, S.; López, S.; Piccolo, V.; Dijkstra, J.; Dhanoa, M.S.; France, J.

    2005-01-01

    An in vitro study was conducted to investigate effects of inoculum source (i.e., sheep versus buffalo rumen fluid) on gas production profiles, and to evaluate the suitability of various mathematical equations to fit the profiles and provide accurate values of degradation attributes. Incubations were

  2. Analysis of cytokine profile and growth factors in platelet-rich plasma obtained by open systems and commercial columns.

    Science.gov (United States)

    Pochini, Alberto de Castro; Antonioli, Eliane; Bucci, Daniella Zanetti; Sardinha, Luiz Roberto; Andreoli, Carlos Vicente; Ferretti, Mario; Ejnisman, Benno; Goldberg, Anna Carla; Cohen, Moisés

    2016-01-01

    To evaluate growth factors and cytokines in samples of platelet-rich plasma obtained by three different centrifugation methods. Peripheral blood of six individuals with no hematological diseases, aged 18 to 68 years, was drawn to obtain platelet-rich plasma, using the open method and commercial columns by Medtronic and Biomet. The products obtained with the different types of centrifugation were submitted to laboratory analysis, including pro-inflammatory cytokines and chemokines by flow cytometry assays, the concentration of fibroblast growth factors-2 (FGF-2) and transforming growth factor-beta1 (TGF-β1). The diverse separation methods generated systematically different profiles regarding number of platelets and leukocytes. The Medtronic system yielded a product with the highest concentration of platelets, and the open method, with the lowest concentration of platelets. The results of cytokine analysis showed that the different types of centrifugation yielded products with high concentrations of interleukin 8, interleukin 1β. The open system resulted in a product with high levels of interleukin 6. Other cytokines and chemokines measured were similar between systems. The product obtained with the open method showed higher levels of TGF-β1 in relation to other systems and low FGF-2 levels. The formed elements, growth factors and cytokines in samples of platelet-rich plasma varied according to the centrifugation technique used. Avaliar fatores de crescimento e citocinas em amostras de plasma rico em plaquetas obtidas por três diferentes métodos de centrifugação. Foi coletado sangue periférico de seis indivíduos, sem doença hematológica, com idades entre 18 e 68 anos, para obtenção de plasma rico em plaquetas, utilizando o método aberto e sistemas comerciais das empresas Medtronic e Biomet. Os produtos obtidos com os diferentes tipos de centrifugação foram submetidos às análises laboratoriais, incluindo citocinas próinflamatórias e quimiocinas

  3. A comparison of vacuum and KBM prosthetic fitting for unilateral transtibial amputees using the Gait Profile Score.

    Science.gov (United States)

    Kuntze Ferreira, Alana Elisabeth; Neves, Eduardo Borba

    2015-02-01

    The purpose of this study was to compare gait deviations between Kondylen Bettung Münster (KBM) and vacuum prosthetic fitting using the Gait Profile Score (GPS), the Movement Analysis Profile (MAP) and temporal-spatial parameters. Seventeen transtibial amputees that received their prosthesis from the Brazilian governmental health system participated in this study. Twelve of them used KBM prosthetic fitting on their prosthesis and five used vacuum prosthetic fitting. Kinematic and temporal-spatial parameters data were captured by a six-camera Motion Analysis system (Santa Rosa, CA). The results showed that the vacuum group walked faster than the KBM group but the differences in temporal-spatial parameters between them were not significant. The GPS for the intact limb (IL) and the overall GPS differentiated between the groups of prosthetic fitting. Hip flexion/extension and knee flexion/extension were higher in KBM group than in the vacuum group, although only knee flexion/extension for the intact limb revealed significant difference between the groups. In KBM group, the major deviations were in hip flexion/extension for both limbs, knee flexion/extension for both limbs and ankle dorsi/plantar flexion for the prosthetic limb. The vacuum group showed deviations especially in ankle dorsi/plantar flexion for both limbs, knee flexion/extension for the prosthetic limb and hip rotation for the prosthetic limb. Besides, the vacuum group was more symmetrical than the KBM group. This study concluded that subjects who used vacuum prosthetic fitting presented smaller gait deviations and a more symmetrical gait than those who used KBM prosthetic fitting. Copyright © 2015 Elsevier B.V. All rights reserved.

  4. Depth profiles of the Doppler-broadening S parameter for polymers obtained with two measuring patterns: The role of accumulated charges

    Energy Technology Data Exchange (ETDEWEB)

    Yang, J. [Key Laboratory of Nuclear Radiation and Nuclear Energy Technology, Institute of High Energy Physics, Chinese Academy of Sciences, No. 19 Yuquan Lu, Beijing 100049 (China); University of Chinese Academy of Sciences, Beijing 100039 (China); Zhang, P.; Lu, E.Y.; Cao, X.Z.; Yu, R.S. [Key Laboratory of Nuclear Radiation and Nuclear Energy Technology, Institute of High Energy Physics, Chinese Academy of Sciences, No. 19 Yuquan Lu, Beijing 100049 (China); Wang, B.Y., E-mail: wangboy@ihep.ac.cn [Key Laboratory of Nuclear Radiation and Nuclear Energy Technology, Institute of High Energy Physics, Chinese Academy of Sciences, No. 19 Yuquan Lu, Beijing 100049 (China)

    2014-03-15

    Highlights: • Depth profiles of S parameter for polymers were obtained with two patterns. • Charges induced by high energy incident positrons can influenced the depth profile. • Depth profiles obtained with energy increase pattern can give real characteristics. - Abstract: Depth profiles of Doppler broadening S parameter for oxygen containing polymer polycarbonate (PC), fluoropolymer poly (tetrafluoroethylene) (PTFE) and chlorine containing polymer polyvinylchloride-unplasticized (UPVC) were obtained with two measuring patterns, i.e. energy increase pattern and energy decrease pattern. The two curves can’t coincide with each other for that a trough appeared between 1 and 5 keV in the curve obtained with energy decrease pattern. It was found that charges induced by high energy incident positrons greatly influenced the annihilation of low energy incident positrons, while charges induced by low energy incident positrons showed little influence on the annihilation of high energy incident positrons. With energy increase measuring pattern, charges induced by low energy incident positrons showed little influence on the annihilation of later incident high energy positrons, thus the measurement can give the depth profile of S parameter in polymer as it was.

  5. Influence of DNA extraction on oral microbial profiles obtained via 16S rRNA gene sequencing

    Directory of Open Access Journals (Sweden)

    Loreto Abusleme

    2014-04-01

    Full Text Available Background and objective: The advent of next-generation sequencing has significantly facilitated characterization of the oral microbiome. Despite great efforts in streamlining the processes of sequencing and data curation, upstream steps required for amplicon library generation could still influence 16S rRNA gene-based microbial profiles. Among upstream processes, DNA extraction is a critical step that could represent a great source of bias. Accounting for bias introduced by extraction procedures is important when comparing studies that use different methods. Identifying the method that best portrays communities is also desirable. Accordingly, the aim of this study was to evaluate bias introduced by different DNA extraction procedures on oral microbiome profiles. Design: Four DNA extraction methods were tested on mock communities consisting of seven representative oral bacteria. Additionally, supragingival plaque samples were collected from seven individuals and divided equally to test two commonly used DNA extraction procedures. Amplicon libraries of the 16S rRNA gene were generated and sequenced via 454-pyrosequencing. Results: Evaluation of mock communities revealed that DNA yield and bacterial species representation varied with DNA extraction methods. Despite producing the lowest yield of DNA, a method that included bead beating was the only protocol capable of detecting all seven species in the mock community. Comparison of the performance of two commonly used methods (crude lysis and a chemical/enzymatic lysis+column-based DNA isolation on plaque samples showed no effect of extraction protocols on taxa prevalence but global community structure and relative abundance of individual taxa were affected. At the phylum level, the latter method improved the recovery of Actinobacteria, Bacteroidetes, and Spirochaetes over crude lysis. Conclusion: DNA extraction distorts microbial profiles in simulated and clinical oral samples, reinforcing the

  6. HPLC Evaluation of Phenolic Profile, Nutritive Content, and Antioxidant Capacity of Extracts Obtained from Punica granatum Fruit Peel

    Directory of Open Access Journals (Sweden)

    Sushil Kumar Middha

    2013-01-01

    Full Text Available This study revealed polyphenolic content, nutritive content, antioxidant activity, and phenolic profile of methanol and aqueous extracts of Punica granatum peel extract. For this, extracts were screened for possible antioxidant activities by free radical scavenging activity (DPPH, hydrogen peroxide scavenging activity and ferric-reducing antioxidant power (FRAP assays. The total phenolics and flavonoid recovered by methanolic (MPE and the water extract (AQPE were ranged from 185 ± 12.45 to 298.00 ± 24.86 mg GAE (gallic acid equivalents/gm and 23.05 ± 1.54 to 49.8 ± 2.14 quercetin (QE mg/g, respectively. The EC50 of herbal extracts ranged from 100 µg/ml (0.38 quercetin equivalents, for AQPE, 168 µg/ml (0.80 quercetin equivalents, for MPE. The phenolic profile in the methanolic extracts was investigated by chromatographic (HPLC method. About 5 different flavonoids, phenolic acids, and their derivatives including quercetin (1, rutin (2, gallic acid (3, ellagic acid (4, and punicalagin as a major ellagitannin (5 have been identified. Among both extracts, methanolic extract was the most effective. This report may be the first to show nutritive content and correlation analysis to suggest that phenols and flavonoids might contribute the high antioxidant activity of this fruit peel and establish it as a valuable natural antioxidant source applicable in the health food industry.

  7. An Inverse Method for Obtaining the Attenuation Profile and Small Variations in the Sound Speed and Density Profiles of the Ocean Bottom.

    Science.gov (United States)

    1985-05-01

    L’-(Pl’ Ing k eriiel for pr,,-fdi 7-1J41 .) 1 ~ Figure 7-30: fEC’.NL Ir. k crud L’ fr pr’cifl T-1.4 (c) P-7 Figure 7-31: L-- 1PH I :r,. - I. ’.1 7-14...Further, the data in the low frequency range are spread over a wide range of values of attenuation and there is no consistent pattern to justify a...studying the peak to null difference in the measured interference pattern . 4 3.2 Determination of the attenuation profile from the plane-wave

  8. Obtaining representative community profiles of anaerobic digesters through optimisation of 16S rRNA amplicon sequencing protocols

    DEFF Research Database (Denmark)

    Kirkegaard, Rasmus Hansen; McIlroy, Simon Jon; Karst, Søren Michael

    RNA gene amplicon sequencing is rapid, cheap, high throughput, and has high taxonomic resolution. However, biases are introduced in multiple steps of this approach, including non-representative DNA extraction and uneven taxonomic coverage of selected PCR primers, potentially giving a skewed view...... of the community composition . As such sample specific optimisation and standardisation of DNA extraction, as well PCR primer selection, are essential to minimising the potential for such biases. The aim of this study was to develop a protocol for optimized community profiling of anaerobic digesters. The Fast......DNA SPIN kit was selected and the mechanical lysis parameters optimised for extraction of genomic DNA from mesophilic and thermophilic anaerobic digester samples. Different primer sets were compared for targeting the archaea and bacteria, both together and individually . Shotgun sequencing...

  9. Chemical profile and antimicrobial activity of Boldo (Peumus boldus Molina extracts obtained by compressed carbon dioxide extraction

    Directory of Open Access Journals (Sweden)

    M. Mazutti

    2008-06-01

    Full Text Available This work reports the effects of temperature (20 to 50ºC and pressure (100 to 250 bar on the extraction yield, chemical characteristics and antimicrobial activity of extracts of Peumus boldus Molina obtained by compressed carbon dioxide extraction. Results showed that the extraction variables affect the extraction yield and the chemical distribution of the major compounds present in the extracts. The extracts were chemically analyzed with regard to 1,8-cineole, trans-sabinene, pinocarveol, pinocarvone, 4-terpineol, ascaridole, piperitone oxide, limonene dioxide and n-eicosane in a GC/MSD. Antimicrobial tests demonstrated that the high-pressure CO2 extracts had activity against 13 bacteria and that better action was verified with extracts obtained at a lower CO2 extraction density and a higher temperature.

  10. Metabolomics profiling of pre-and post-anesthesia plasma samples of colorectal patients obtained via Ficoll separation

    OpenAIRE

    Ghini, Veronica; Unger, Florian T; Tenori, Leonardo; Turano, Paola; Juhl, Hartmut; David, Kerstin A.

    2015-01-01

    1H NMR spectroscopy was used to investigate the metabolic consequences of general anesthesia in the plasma of two groups of patients with diagnosis for non-metastatic colorectal cancer and metastatic colorectal cancer with liver-metastasis, respectively. Patients were treated with etomidate or propofol, two frequently used sedation agents. Plasma samples were obtained via Ficoll separation. Here, we demonstrated that this procedure introduces a number of limitations for NMR-based metabolomics...

  11. Mass Spectrometry-Based Proteomic Profiling of Thrombotic Material Obtained by Endovascular Thrombectomy in Patients with Ischemic Stroke

    Directory of Open Access Journals (Sweden)

    Roberto Muñoz

    2018-02-01

    Full Text Available Thrombotic material retrieved from acute ischemic stroke (AIS patients represents a valuable source of biological information. In this study, we have developed a clinical proteomics workflow to characterize the protein cargo of thrombi derived from AIS patients. To analyze the thrombus proteome in a large-scale format, we developed a workflow that combines the isolation of thrombus by endovascular thrombectomy and peptide chromatographic fractionation coupled to mass-spectrometry. Using this workflow, we have characterized a specific proteomic expression profile derived from four AIS patients included in this study. Around 1600 protein species were unambiguously identified in the analyzed material. Functional bioinformatics analyses were performed, emphasizing a clustering of proteins with immunological functions as well as cardiopathy-related proteins with blood-cell dependent functions and peripheral vascular processes. In addition, we established a reference proteomic fingerprint of 341 proteins commonly detected in all patients. Protein interactome network of this subproteome revealed protein clusters involved in the interaction of fibronectin with 14-3-3 proteins, TGFβ signaling, and TCP complex network. Taken together, our data contributes to the repertoire of the human thrombus proteome, serving as a reference library to increase our knowledge about the molecular basis of thrombus derived from AIS patients, paving the way toward the establishment of a quantitative approach necessary to detect and characterize potential novel biomarkers in the stroke field.

  12. Vertical microphysical profiles of convective clouds as a tool for obtaining aerosol cloud-mediated climate forcings

    Energy Technology Data Exchange (ETDEWEB)

    Rosenfeld, Daniel [Hebrew Univ. of Jerusalem (Israel)

    2015-12-23

    Quantifying the aerosol/cloud-mediated radiative effect at a global scale requires simultaneous satellite retrievals of cloud condensation nuclei (CCN) concentrations and cloud base updraft velocities (Wb). Hitherto, the inability to do so has been a major cause of high uncertainty regarding anthropogenic aerosol/cloud-mediated radiative forcing. This can be addressed by the emerging capability of estimating CCN and Wb of boundary layer convective clouds from an operational polar orbiting weather satellite. Our methodology uses such clouds as an effective analog for CCN chambers. The cloud base supersaturation (S) is determined by Wb and the satellite-retrieved cloud base drop concentrations (Ndb), which is the same as CCN(S). Developing and validating this methodology was possible thanks to the ASR/ARM measurements of CCN and vertical updraft profiles. Validation against ground-based CCN instruments at the ARM sites in Oklahoma, Manaus, and onboard a ship in the northeast Pacific showed a retrieval accuracy of ±25% to ±30% for individual satellite overpasses. The methodology is presently limited to boundary layer not raining convective clouds of at least 1 km depth that are not obscured by upper layer clouds, including semitransparent cirrus. The limitation for small solar backscattering angles of <25º restricts the satellite coverage to ~25% of the world area in a single day. This methodology will likely allow overcoming the challenge of quantifying the aerosol indirect effect and facilitate a substantial reduction of the uncertainty in anthropogenic climate forcing.

  13. Gene expression profiles of Beta-cell enriched tissue obtained by laser capture microdissection from subjects with type 2 diabetes.

    Directory of Open Access Journals (Sweden)

    Lorella Marselli

    2010-07-01

    Full Text Available Changes in gene expression in pancreatic beta-cells from type 2 diabetes (T2D should provide insights into their abnormal insulin secretion and turnover.Frozen sections were obtained from cadaver pancreases of 10 control and 10 T2D human subjects. Beta-cell enriched samples were obtained by laser capture microdissection (LCM. RNA was extracted, amplified and subjected to microarray analysis. Further analysis was performed with DNA-Chip Analyzer (dChip and Gene Set Enrichment Analysis (GSEA software. There were changes in expression of genes linked to glucotoxicity. Evidence of oxidative stress was provided by upregulation of several metallothionein genes. There were few changes in the major genes associated with cell cycle, apoptosis or endoplasmic reticulum stress. There was differential expression of genes associated with pancreatic regeneration, most notably upregulation of members of the regenerating islet gene (REG family and metalloproteinase 7 (MMP7. Some of the genes found in GWAS studies to be related to T2D were also found to be differentially expressed. IGF2BP2, TSPAN8, and HNF1B (TCF2 were upregulated while JAZF1 and SLC30A8 were downregulated.This study made possible by LCM has identified many novel changes in gene expression that enhance understanding of the pathogenesis of T2D.

  14. Metabolite profiling of Clinacanthus nutans leaves extracts obtained from different drying methods by 1H NMR-based metabolomics

    Science.gov (United States)

    Hashim, Noor Haslinda Noor; Latip, Jalifah; Khatib, Alfi

    2016-11-01

    The metabolites of Clinacanthus nutans leaves extracts and their dependence on drying process were systematically characterized using 1H nuclear magnetic resonance spectroscopy (NMR) multivariate data analysis. Principal component analysis (PCA) and partial least square-discriminant analysis (PLS-DA) were able to distinguish the leaves extracts obtained from different drying methods. The identified metabolites were carbohydrates, amino acid, flavonoids and sulfur glucoside compounds. The major metabolites responsible for the separation in PLS-DA loading plots were lupeol, cycloclinacosides, betulin, cerebrosides and choline. The results showed that the combination of 1H NMR spectroscopy and multivariate data analyses could act as an efficient technique to understand the C. nutans composition and its variation.

  15. Analysis of synthetic profile of CZTS as photovoltaic material obtained with variations of titanium and TiN

    Science.gov (United States)

    Muñoz, M.; Vera, E.; Gómez, J.; Pineda, Y.

    2017-12-01

    Semiconductor type Cu2ZnTiS4 (CZTiS) and Cu2ZnSnS4 (CZTS),were synthetized starting from a hydrothermal route from precursor powders such as copper, zinc, tin, titanium isopropoxide and tiocarbammide metal nitrates dissolved in deionized water in concentrations of 1molL-1. Dosed and placed in a steel autoclave equipped with a Teflon jacket under magnetic stirring (150rpm) and at a temperature of 300°C for 24 hours in order to promote the formation of the respective ceramic phases. Segregates have been repeatedly washed with ethanol at all times until obtaining crystalline-looking solids. Subsequently, in order to promote the production of pure crystalline phases, the materials were subjected to a second reaction stage in a tubular furnace at 400°C in flow (50mLmin-1) for the purpose of Reduce the concentration of secondary phases of sulphides. The characterization of the CZTiS and CZTS materials was performed by X-ray Diffraction (XRD) and Raman spectroscopy where the presence of Kesterite type crystalline structures was confirmed in the two materials revealing that the effect of titanium with a higher ionic radius than tin produces a distortion in the cell of the CZTiS material compared to the report for the CZTS system. The results of Scanning Electron Microscopy (SEM), confirm the regular aggregates obtained with composition consistent with the proposal theoretically and validated by Energy-Dispersion X-ray Spectroscopy (EDX) techniques and comparison between secondary emission spectra and Retro-dispersed.

  16. Detection and validation of unscalable item score patterns using item response theory: an illustration with Harter's Self-Perception Profile for Children.

    Science.gov (United States)

    Meijer, Rob R; Egberink, Iris J L; Emons, Wilco H M; Sijtsma, Klaas

    2008-05-01

    We illustrate the usefulness of person-fit methodology for personality assessment. For this purpose, we use person-fit methods from item response theory. First, we give a nontechnical introduction to existing person-fit statistics. Second, we analyze data from Harter's (1985) Self-Perception Profile for Children (Harter, 1985) in a sample of children ranging from 8 to 12 years of age (N = 611) and argue that for some children, the scale scores should be interpreted with care and caution. Combined information from person-fit indexes and from observation, interviews, and self-concept theory showed that similar score profiles may have a different interpretation. For some children in the sample, item scores did not adequately reflect their trait level. Based on teacher interviews, this was found to be due most likely to a less developed self-concept and/or problems understanding the meaning of the questions. We recommend investigating the scalability of score patterns when using self-report inventories to help the researcher interpret respondents' behavior correctly.

  17. Molecular structures of fluid phosphatidylethanolamine bilayers obtained from simulation-to-experiment comparisons and experimental scattering density profiles.

    Science.gov (United States)

    Kučerka, Norbert; van Oosten, Brad; Pan, Jianjun; Heberle, Frederick A; Harroun, Thad A; Katsaras, John

    2015-02-05

    Following our previous efforts in determining the structures of commonly used PC, PG, and PS bilayers, we continue our studies of fully hydrated, fluid phase PE bilayers. The newly designed parsing scheme for PE bilayers was based on extensive MD simulations, and is utilized in the SDP analysis of both X-ray and neutron (contrast varied) scattering measurements. Obtained experimental scattering form factors are directly compared to our simulation results, and can serve as a benchmark for future developed force fields. Among the evaluated structural parameters, namely, area per lipid A, overall bilayer thickness DB, and hydrocarbon region thickness 2DC, the PE bilayer response to changing temperature is similar to previously studied bilayers with different headgroups. On the other hand, the reduced hydration of PE headgroups, as well as the strong hydrogen bonding between PE headgroups, dramatically affects lateral packing within the bilayer. Despite sharing the same glycerol backbone, a markedly smaller area per lipid distinguishes PE from other bilayers (i.e., PC, PG, and PS) studied to date. Overall, our data are consistent with the notion that lipid headgroups govern bilayer packing, while hydrocarbon chains dominate the bilayer's response to temperature changes.

  18. Physicochemical and dissolution profile characterization of pellets containing different binders obtained by the extrusion-spheronization process

    Directory of Open Access Journals (Sweden)

    Michele Georges Issa

    2012-09-01

    Full Text Available With the purpose of evaluating the behavior of different polymers employed as binders in small-diameter pellets for oral administration, we prepared formulations containing paracetamol and one of the following polymers: PVP, PEG 1500, hydroxypropylmethylcellulose and methylcellulose, and we evaluated their different binding properties. The pellets were obtained by the extrusion/spheronization process and were subsequently subjected to fluid bed drying. In order to assess drug delivery, the United States Pharmacopeia (USP apparatus 3 (Bio-Dis was employed, in conjunction with the method described by the same pharmacopeia for the dissolution of paracetamol tablets (apparatus 1. The pellets were also evaluated for granulometry, friability, true density and drug content. The results indicate that the different binders used are capable of affecting production in different ways, and some of the physicochemical characteristics of the pellets, as well as the dissolution test, revealed that the formulations acted like immediate-release products. The pellets obtained presented favorable release characteristics for orally disintegrating tablets. USP apparatus 3 seems to be more adequate for discriminating among formulations than the basket method.Com a finalidade de se avaliar o comportamento de diferentes polímeros empregados como aglutinantes em pellets de pequeno diâmetro para uso oral foram preparadas formulações contendo paracetamol e um dos seguintes polímeros: PVP, PEG 1500, hidroxipropilmetilcelulose e metilcelulose por apresentarem diferentes propriedades aglutinantes. Os pellets foram obtidos pelo processo de extrusão/esferonização e secagem em leito fluidizado. Para avaliar a liberação do fármaco, empregou-se o método 3 da Farmacopeia Americana, também conhecido como Bio-Dis e o método preconizado pela mesma farmacopeia para comprimidos de paracetamol. Os pellets foram avaliados, ainda, com relação à granulometria, friabilidade

  19. Clonality, virulence determinants, and profiles of resistance of clinical Acinetobacter baumannii isolates obtained from a Spanish hospital.

    Directory of Open Access Journals (Sweden)

    Elias Dahdouh

    Full Text Available Acinetobacter baumannii is a nosocomial pathogen that is showing increasing rates of carbapenem resistance. Multi-Drug Resistant (MDR International Clones (ICs, associated with certain oxacillinases, are being reported globally. This organism also harbors numerous virulence determinants. In this study, we aim at characterizing A. baumannii isolated from a Spanish hospital in terms of antimicrobial susceptibility, clonality, carbapenemase genes harbored, and virulence determinants expressed.Fifty nine clinical bloodstream isolates were obtained from 2009 until 2013. Antimicrobial Susceptibility Testing was performed according to the CLSI guidelines. PFGE and tri-locus PCR typing were then performed in order to determine local and international clonality. PCRs for the detection of common carbapenemases were also performed. Production of hemolysis, biofilms, siderophores, surface motility, and proteolysis were determined phenotypically. Doubling times for selected strains were also calculated. Finally, statistical analysis for detecting associations between these factors was conducted.Carbapenem non-susceptibility was 84.75%, suggesting the immediate need for intervention. PFGE showed the distribution of the majority of the isolates among 7 clusters. Although all three ICs were detected, IC II was predominant at 71.19%. blaOXA-24-like was the most prevalent carbapenemase (62.71%, followed by blaOXA-58-like (13.56%, and blaOXA-23-like (11.86%. Strains pertaining to IC II, and those harboring blaOXA-24-like, were positively associated with α-hemolysis, production of strong biofilms, and siderophore production. Harboring blaOXA-23-like and blaOXA-58-like was associated with attenuated virulence. These associations suggest that an interplay exists between these factors that could be locally exploited.An alarmingly high rate of carbapenem non-susceptibility has been detected in this study. There was a predominance of IC II and blaOXA-24-like, and those

  20. Evaluation of volatile profiles obtained for minimally-processed pineapple fruit samples during storage by headspace-solid phase microextraction gas chromatography-mass spectrometry

    Directory of Open Access Journals (Sweden)

    Francielle Crocetta TURAZZI

    Full Text Available Abstract This paper describes the application of the solid-phase microextraction (SPME technique for the determination and monitoring of the volatile profile of minimally-processed pineapple fruit stored at various temperatures (-12 °C, 4 °C and 25 °C for different periods (1, 4 and 10 days. The SPME fiber coating composed of Car/PDMS presented the best performance. The optimal extraction conditions obtained through a Doehlert design were 60 min at 35 °C. The profiles for the volatile compounds content of the fruit at each stage of storage were determined by gas chromatography-mass spectrometry (GC-MS. The variation in the volatile profile over time was greater when the fruit samples were stored at 25 °C and at -12 °C compared to 4 °C. Thus, according to the volatile profiles associated with the storage conditions evaluated in this study, packaged pineapple retains best its fresh fruit aroma when stored at 4 °C.

  1. Music Teacher Licensure Candidates in the United States: A Demographic Profile and Analysis of Licensure Examination Scores

    Science.gov (United States)

    Elpus, Kenneth

    2015-01-01

    The purpose of this study was to analyze the demographic profile of candidates seeking music teacher licensure in the United States and to understand whether performance on the Praxis II music teacher licensure tests varies systematically as a function of various demographic characteristics. Praxis II music test data and background questionnaire…

  2. Genetic Polymorphisms and Phenotypic Profiles of Sulfadiazine-Resistant and Sensitive Toxoplasma gondii Isolates Obtained from Newborns with Congenital Toxoplasmosis in Minas Gerais, Brazil.

    Science.gov (United States)

    Silva, Letícia Azevedo; Reis-Cunha, João Luís; Bartholomeu, Daniella Castanheira; Vítor, Ricardo Wagner Almeida

    2017-01-01

    Previous Toxoplasma gondii studies revealed that mutations in the dhps (dihydropteroate synthase) gene are associated with resistance to sulfonamides. Although Brazilian strains are genotypically different, very limited data are available regarding the susceptibility of strains obtained from human to sulfonamides. The aim of this study was to evaluate the efficacy of sulfadiazine (SDZ) against Brazilian isolates of T. gondii and verify whether isolates present polymorphisms in the dhps gene. We also investigated whether the virulence-phenotype and/or genotype were associated with the profile of susceptibility to SDZ. Five T. gondii isolates obtained from newborns with congenital toxoplasmosis were used to verify susceptibility. Mice were infected with 104 tachyzoites and orally treated with different doses of SDZ. The mortality curve was evaluated by the Log-rank test. The presence of polymorphisms in the dhps gene was verified using sequencing. A descriptive analysis for 11 Brazilian isolates was used to assess the association between susceptibility, genotype, and virulence-phenotype. Statistical analysis showed that TgCTBr03, 07, 08, and 16 isolates were susceptible to SDZ, whereas TgCTBr11 isolate presented a profile of resistance to SDZ. Nineteen polymorphisms were identified in dhps exons. Seven polymorphisms corresponded to non-synonymous mutations, with four being new mutations, described for the first time in this study. No association was found between the profile of susceptibility and the virulence-phenotype or genotype of the parasite. There is a high variability in the susceptibilities of Brazilian T. gondii strains to SDZ, with evidence of drug resistance. Despite the large number of polymorphisms identified, the profile of susceptibility to SDZ was not associated with any of the dhps variants identified in this study. Other genetic factors, not yet determined, may be associated with the resistance to SDZ; thus, further studies are needed as a basis

  3. Genetic Polymorphisms and Phenotypic Profiles of Sulfadiazine-Resistant and Sensitive Toxoplasma gondii Isolates Obtained from Newborns with Congenital Toxoplasmosis in Minas Gerais, Brazil.

    Directory of Open Access Journals (Sweden)

    Letícia Azevedo Silva

    Full Text Available Previous Toxoplasma gondii studies revealed that mutations in the dhps (dihydropteroate synthase gene are associated with resistance to sulfonamides. Although Brazilian strains are genotypically different, very limited data are available regarding the susceptibility of strains obtained from human to sulfonamides. The aim of this study was to evaluate the efficacy of sulfadiazine (SDZ against Brazilian isolates of T. gondii and verify whether isolates present polymorphisms in the dhps gene. We also investigated whether the virulence-phenotype and/or genotype were associated with the profile of susceptibility to SDZ.Five T. gondii isolates obtained from newborns with congenital toxoplasmosis were used to verify susceptibility. Mice were infected with 104 tachyzoites and orally treated with different doses of SDZ. The mortality curve was evaluated by the Log-rank test. The presence of polymorphisms in the dhps gene was verified using sequencing. A descriptive analysis for 11 Brazilian isolates was used to assess the association between susceptibility, genotype, and virulence-phenotype.Statistical analysis showed that TgCTBr03, 07, 08, and 16 isolates were susceptible to SDZ, whereas TgCTBr11 isolate presented a profile of resistance to SDZ. Nineteen polymorphisms were identified in dhps exons. Seven polymorphisms corresponded to non-synonymous mutations, with four being new mutations, described for the first time in this study. No association was found between the profile of susceptibility and the virulence-phenotype or genotype of the parasite.There is a high variability in the susceptibilities of Brazilian T. gondii strains to SDZ, with evidence of drug resistance. Despite the large number of polymorphisms identified, the profile of susceptibility to SDZ was not associated with any of the dhps variants identified in this study. Other genetic factors, not yet determined, may be associated with the resistance to SDZ; thus, further studies are

  4. Atypical Cross-Modal Profiles and Longitudinal Associations Between Vocabulary Scores in Initially Minimally Verbal Children With ASD.

    Science.gov (United States)

    Woynaroski, Tiffany; Yoder, Paul; Watson, Linda R

    2016-02-01

    We tested the relative levels (i.e., age equivalencies) of concurrent cross-modality (receptive and expressive) vocabulary and the relative strength of the longitudinal, cross-modality associations between early and later vocabulary sizes in minimally verbal preschoolers with ASD. Eighty-seven children participated. Parent-reported vocabulary was assessed at four periods separated by 4 months each. Expressive age equivalent scores were higher than receptive age equivalent scores at all four periods. Cross-lagged panel analysis was used to rule out common, but trivial, explanations for differences between the longitudinal associations of interest. Key associations were tested across intervals that varied from 8 to 12 months. In two of the three tested panels, the associations between early expressive vocabulary size and later receptive vocabulary size were stronger than the associations between early receptive vocabulary size and later expressive vocabulary size, providing evidence that is consistent with the hypothesis that expressive vocabulary size drives receptive vocabulary size in minimally verbal preschoolers with ASD. © 2015 International Society for Autism Research, Wiley Periodicals, Inc.

  5. Comparison of seven methods for producing Affymetrix expression scores based on False Discovery Rates in disease profiling data

    Directory of Open Access Journals (Sweden)

    Gruber Stephen B

    2005-02-01

    Full Text Available Abstract Background A critical step in processing oligonucleotide microarray data is combining the information in multiple probes to produce a single number that best captures the expression level of a RNA transcript. Several systematic studies comparing multiple methods for array processing have used tightly controlled calibration data sets as the basis for comparison. Here we compare performances for seven processing methods using two data sets originally collected for disease profiling studies. An emphasis is placed on understanding sensitivity for detecting differentially expressed genes in terms of two key statistical determinants: test statistic variability for non-differentially expressed genes, and test statistic size for truly differentially expressed genes. Results In the two data sets considered here, up to seven-fold variation across the processing methods was found in the number of genes detected at a given false discovery rate (FDR. The best performing methods called up to 90% of the same genes differentially expressed, had less variable test statistics under randomization, and had a greater number of large test statistics in the experimental data. Poor performance of one method was directly tied to a tendency to produce highly variable test statistic values under randomization. Based on an overall measure of performance, two of the seven methods (Dchip and a trimmed mean approach are superior in the two data sets considered here. Two other methods (MAS5 and GCRMA-EB are inferior, while results for the other three methods are mixed. Conclusions Choice of processing method has a major impact on differential expression analysis of microarray data. Previously reported performance analyses using tightly controlled calibration data sets are not highly consistent with results reported here using data from human tissue samples. Performance of array processing methods in disease profiling and other realistic biological studies should be

  6. A five-factor biomarker profile obtained week 4-12 of treatment for improved prognostication in metastatic renal cell carcinoma

    DEFF Research Database (Denmark)

    Soerensen, Anne V; Geertsen, Poul F; Christensen, Ib J

    2015-01-01

    BACKGROUND: Several biomarkers of treatment efficacy have been associated with a better prognosis in patients with metastatic renal cell carcinoma (mRCC). The prognostic significance of biomarkers in the early treatment phase is unclear. MATERIAL AND METHODS: In a complete national cohort of m......RCC patients receiving first-line tyrosine kinase inhibitors (TKI) or interleukin-2 based immunotherapy (IT) from 2006 to 2010, overall survival (OS) was analysed for baseline International mRCC Database Consortium (IMDC) classification factors and on-treatment time-dependent biomarkers obtained day 1 each...... analyses stratified for TKI and IT (p ≤ 0.04). Concordance (C)-index for IMDC classification alone was 0.625 (95% CI 0.59-0.66) and combined with the five-factor biomarker profile 0.683 (95% CI 0.64-0.72). For patients with good (3-5 factors) and poor (0-2 factors) biomarker profile median OS were 23...

  7. Comparison of biogenic amine and polyphenol profiles of grape berries and wines obtained following conventional, organic and biodynamic agricultural and oenological practices.

    Science.gov (United States)

    Tassoni, Annalisa; Tango, Nunzio; Ferri, Maura

    2013-08-15

    The bio-active compounds present in food and beverages have a high potential influence on the future health of humans. The levels of biogenic amines, anthocyanins, polyphenols and antioxidant activity were measured in white (Pignoletto) and red (Sangiovese) grape berries and wines from the Emilia-Romagna region (Italy) obtained following conventional, organic and biodynamic agricultural and oenological practices. No significant difference was shown among the samples coming from different agricultural and winemaking practices. Principal Component Analysis was also performed. Biogenic amine amounts were higher in red than in white berries, while in the wines an opposite trend was observed, with histamine, tyramine and putrescine being the most abundant in Pignoletto wines. Red grapes and wines were richer in anthocyanins and showed higher antioxidant activity than white ones. The total level of polyphenols was similar in red and white berries, but with different metabolite profiles depending on the grape variety. Copyright © 2013 Elsevier Ltd. All rights reserved.

  8. Technical note: a proposed method to determine the extent of degradation of a feed in the rumen from the degradation profile obtained with the in vitro gas production technique using feces as the inoculum

    NARCIS (Netherlands)

    Dhanoa, M.S.; France, J.; Crompton, L.A.; Mauricio, R.M.; Kebreab, E.; Mills, J.A.N.; Sanderson, R.; Dijkstra, J.; Lopez, S.

    2004-01-01

    A method is proposed to determine the extent of degradation in the rumen involving a two-stage mathematical modeling process. In the first stage, a statistical model shifts (or maps) the gas accumulation profile obtained using a fecal inoculum to a ruminal gas profile. Then, a kinetic model

  9. A simple method to obtain very accurate whole atom Compton profiles from photon scattering doubly differential cross sections in relativistic regimes

    Science.gov (United States)

    Lajohn, Larry

    2017-04-01

    Compton profiles (CP) are used in many ways such as for assessing the bonding properties of molecules and solids including semiconductors. The simplest approach to obtain a CP from doubly differential cross sections (DDCS) is to use the nonrelativistic (nr) impulse approximation (IA) expression DDCS =KJ where K is the kinematic factor and J is the CP. A relativistic version of this expression to be referred to as RKJ, an approximation to the full relativistic IA expression is used for relativistic regimes, but it does not give accurate results for the inner and middle shells of moderate to heavy atoms. For example the RKJ error ranges from 3% (Z =30) to about 28% (Z =92) for the K-shell and about 3% (Z =50) to 17% (Z =92) for the 2p shell and is at 6% for 3d (Z =92). In the present work, expressions from nonrelativistic hydrogenlike wavefunctions (with a relativistic QED K) to correct RKJ beyond the K-shell to L and M shells were derived such that relativistic contributions as well as screening effects largely cancel for any regime of energy angle and Z. As a result the RKJ error is reduced to less than 2% over 99% of the momentum distribution range of any subshell CP.

  10. Comparison of cardiovascular risk factors and biochemical profile in patients with cardiac syndrome X and obstructive coronary artery disease: A propensity score-matched study.

    Science.gov (United States)

    Vasheghani-Farahani, Ali; Nouri, Nasrin; Seifirad, Soroush; Sheikh Fathollahi, Mahmood; Hakki, Elham; Alidoosti, Mohammad; Davoodi, Gholamreza; Masoudkabir, Farzad; Poorhosseini, Hamidreza

    2013-09-01

    This study was designed to compare the frequency of conventional cardiovascular disease risk factors and clinical biochemistry profile in patients with cardiac syndrome X (CSX) and obstructive coronary artery disease (CAD). A cross-sectional study was conducted on patients with typical angina and positive exercise tolerance test undergoing coronary angiography in our center. 342 consecutive patients with CSX were enrolled into this study and were matched regarding age and sex with 342 patients with acute coronary syndrome (ACS) and also 342 patients with chronic stable angina (SA). Cardiovascular risk factors as well as biochemistry profile of the patients were recorded. Mean age of the studied patients was 53.0 years and 41.5% were male. There was no significant difference between the CSX patients and CAD patients regarding body mass index (BMI). Frequency of diabetes mellitus, hyperlipidemia, smoking, family history of premature CAD and hypertension was significantly lower in patients with CSX than ACS and SA patients. Patients with CSX had significantly higher levels of high-density lipoprotein cholesterol (HDL-cholesterol) than comparators while the levels of low-density lipoprotein cholesterol (LDL-cholesterol), total cholesterol, triglyceride and fasting blood sugar (FBS) were significantly lower in patients with CSX than CAD patients. The present study demonstrated that CSX patients had substantially lower frequency of all conventional CVD risk factors than patients with obstructive CAD. This might aid in developing novel scoring systems or appropriateness criteria for angiographic evaluation of patients with typical angina and positive exercise test in order to reduce the rate of negative results.

  11. Programs to obtain vertical heights from mean sea level and for computing volume of sand/mineral along beaches:A case study with Kalbadevi beach profiling data and results.

    Digital Repository Service at National Institute of Oceanography (India)

    Ganesan, P.

    II) Program for obtaining volume of sand / mineral along profiles from M.S.L. The listing of the software is given in Annexure: I and Annexure :2 of this report. LOGIC AND FLOW DIAGRAM The logic used in first program ?Program to obtain... data points from second set up = (HC1 ? successive staff readings observed from second set up) 5 The logical flow diagram is given below Fig.1 Flow chart for obtaining vertical heights with respect to mean sea...

  12. On the energy distribution profile of interface states obtained by taking into account of series resistance in Al/TiO{sub 2}/p-Si (MIS) structures

    Energy Technology Data Exchange (ETDEWEB)

    Pakma, O., E-mail: osman@pakma.co [Department of Physics, Faculty of Sciences and Arts, Batman University, Batman (Turkey); Serin, N.; Serin, T. [Department of Engineering Physics, Faculty of Engineering, Ankara University, 06100 Tandogan, Ankara (Turkey); Altindal, S. [Physics Department, Faculty of Arts and Sciences, Gazi University, Teknikokullar, 06500 Ankara (Turkey)

    2011-02-15

    The energy distribution profile of the interface states (N{sub ss}) of Al/TiO{sub 2}/p-Si (MIS) structures prepared using the sol-gel method was obtained from the forward bias current-voltage (I-V) characteristics by taking into account both the bias dependence of the effective barrier height ({phi}{sub e}) and series resistance (R{sub s}) at room temperature. The main electrical parameters of the MIS structure such as ideality factor (n), zero-bias barrier height ({phi}{sub b0}) and average series resistance values were found to be 1.69, 0.519 eV and 659 {Omega}, respectively. This high value of n was attributed to the presence of an interfacial insulator layer at the Al/p-Si interface and the density of interface states (N{sub ss}) localized at the Si/TiO{sub 2} interface. The values of N{sub ss} localized at the Si/TiO{sub 2} interface were found with and without the R{sub s} at 0.25-E{sub v} in the range between 8.4x10{sup 13} and 4.9x10{sup 13} eV{sup -1} cm{sup -2}. In addition, the frequency dependence of capacitance-voltage (C-V) and conductance-voltage (G/{omega}-V) characteristics of the structures have been investigated by taking into account the effect of N{sub ss} and R{sub s} at room temperature. It can be found out that the measured C and G/{omega} are strongly dependent on bias voltage and frequency. -- Research highlights: {yields}We successfully fabricated Al/TiO{sub 2}/p-Si device with interlayer by a sol-gel method. The facts: (i) that the technology of the fabrication of a Al/TiO{sub 2}/p-Si MIS structure much simpler and economical than that for the Si p-n junction and (b) the main advantages of TiO{sub 2} films are low densities of the surface states when compared to SiO{sub 2}.

  13. Hormonal profile in children with isolated hypospadias associates better with comprehensive score of local anatomical factors as compared to meatal location or degree of chordee

    Directory of Open Access Journals (Sweden)

    Simmi K Ratan

    2014-01-01

    Full Text Available Background: To evaluate if hormonal profile of children with isolated hypospadias (IH associates better with comprehensive local anatomical factor score (LAFS than with clinically adjudged urethral meatus location or severity of chordee/k.j. Material and Methods: Ninety-nine children with IH were enrolled, as per inclusion criteria. Meatal location was recorded at first clinical examination in OPD; while LAFS was computed per-operatively using indigenously devised scale, except for neonates. Hypospadiacs were first classified into three standard meatal based groups and subsequently into LAFS based two groups (≤19, >19. For all participants, pre HCG and post HCG (96 hour post- injection estimation of serum gonadotropins, DHEA-S, estrogen (E, progesterone (P, testosterone (T and Dihydrotestosterone (DHT was done. Statistical tests were applied to assess significance of hormonal levels with respect to meatal location, chordee and LAFS. Results: Only FSH levels differed significantly among meatal based groups; while among LAFS groups, multiple hormonal differences were noted; with poor LAFS associated significantly with higher FSH, LH and lower E, T/DHT. Children with severe degree of chordee had poorer T output and a significantly lower LAFS as compared to those with moderate/mild chordee. Conclusion: Serotoli cell dysfunction, indirectly indicated by high FSH was found among midpenile hypospadiacs and those with poorer LAFS. Since groups based on LAFS revealed multiple intergroup hormonal differences than what was seen for meatal/chordee based groups; LAFS should be considered a better guide for prognostication and for deciding about hormonal supplementation. Lower androgenic output was particularly noted in children with severe chordee.

  14. Phytochemical profile, antioxidant and antimicrobial activity of extracts obtained from erva-mate (Ilex paraguariensis) fruit using compressed propane and supercritical CO2

    National Research Council Canada - National Science Library

    Fernandes, Ciro E. F; Scapinello, Jaqueline; Bohn, Aline; Boligon, Aline A; Athayde, Margareth L; Magro, Jacir Dall; Palliga, Marshall; Oliveira, J Vladimir; Tres, Marcus V

    .... The aim of this work to evaluate phytochemical properties, total phenolic compounds, antioxidant and antimicrobial activity of extracts of Ilex paraguariensis fruits obtained from supercritical CO2...

  15. Programs to obtain vertical heights from mean sea level and for computing volume of sand/mineral along beaches: A case study with Kalbadevi beach profiling data and results

    Digital Repository Service at National Institute of Oceanography (India)

    Ganesan, P.

    Two programs have been developed to process profile data, for obtaining vertical heights with respect to mean sea level (M.S.L.) and for computation of volume of heavy mineral / sand accumulation or erosion along the beaches. The final output...

  16. Dietary fat and total energy intake modifies the association of genetic profile risk score on obesity: evidence from 48 170 UK Biobank participants.

    Science.gov (United States)

    Celis-Morales, C A; Lyall, D M; Gray, S R; Steell, L; Anderson, J; Iliodromiti, S; Welsh, P; Guo, Y; Petermann, F; Mackay, D F; Bailey, M E S; Pell, J P; Gill, J M R; Sattar, N

    2017-12-01

    Obesity is a multifactorial condition influenced by both genetics and lifestyle. The aim of this study was to investigate whether the association between a validated genetic profile risk score for obesity (GPRS-obesity) and body mass index (BMI) or waist circumference (WC) was modified by macronutrient intake in a large general population study. This study included cross-sectional data from 48 170 white European adults, aged 37-73 years, participating in the UK Biobank. Interactions between GPRS-obesity and macronutrient intake (including total energy, protein, fat, carbohydrate and dietary fibre intake) and its effects on BMI and WC were investigated. The 93-single-nucleotide polymorphism (SNP) GPRS was associated with a higher BMI (β: 0.57 kg m - 2 per s.d. increase in GPRS (95% confidence interval: 0.53-0.60); P=1.9 × 10 -183 ) independent of major confounding factors. There was a significant interaction between GPRS and total fat intake (P ( interaction) =0.007). Among high-fat-intake individuals, BMI was higher by 0.60 (0.52, 0.67) kg m -2 per s.d. increase in GPRS-obesity; the change in BMI with GPRS was lower among low-fat-intake individuals (β: 0.50 (0.44, 0.57) kg m -2 ). Significant interactions with similar patterns were observed for saturated fat intake (high β: 0.66 (0.59, 0.73) versus low β: 0.49 (0.42, 0.55) kg m -2 , P ( interaction) =2 × 10 -4 ) and for total energy intake (high β: 0.58 (0.51, 0.64) versus low β: 0.49 (0.42, 0.56) kg m -2 , P ( interaction) =0.019), but not for protein intake, carbohydrate intake and fibre intake (P ( interaction) >0.05). The findings were broadly similar using WC as the outcome. These data suggest that the benefits of reducing the intake of fats and total energy intake may be more important in individuals with high genetic risk for obesity.

  17. Inorganic profile of some Brazilian medicinal plants obtained from ethanolic extract and ''in natura'' samples

    Energy Technology Data Exchange (ETDEWEB)

    Ferreira, M.O.M.; de Sousa, P.T.; Salvador, V.L.R.; Sato, I.M.

    2004-10-03

    The Anadenathera macrocarpa, Schinus molle, Hymenaea courbaril, Cariniana legalis, Solidago microglossa and Stryphnodendron barbatiman, were collected ''in natura'' samples (leaves, flowers, barks and seeds) from different commercial suppliers. The pharmaco-active compounds in ethanolic extracts had been made by the Mato Grosso Federal University (UFMT). The energy-dispersive x-ray fluorescence (ED-XRF) spectrometry was used for the elemental analysis in different parts of the plants and respective ethanolic extracts. The Ca, Cl, Cu, Fe, K, Mg, Mn, Na, Ni, P, Rb, S, Sr and Zn concentrations were determined by the fundamental parameters method. Some specimens showed a similar inorganic profile for ''in natura'' and ethanolic extract samples and some ones showed a distinct inorganic profile. For example, the Anadenathera macrocarpa showed a similar concentration in Mg, P, Cu, Zn and Rb elements in ''in natura'' and ethanolic extract samples; however very different concentration in Na, S, Cl, K , Ca, Mn, Fe and Sr was observed in distinctive samples. The Solidago microglossa showed the K, Ca, Cl, S, Mg, P and Fe elements as major constituents in both samples, suggesting that the extraction process did not affect in a considerable way the ''in natura'' inorganic composition. The elemental composition of the different parts of the plants (leaves, flowers, barks and seeds) has been also determined. For example, the Schinus molle specimen showed P, K, Cl and Ca elements as major constituents in the seeds, Mg, K and Sr in the barks and Mg, S, Cl and Mn in the leaves, demonstrating a differentiated elementary distribution. These inorganic profiles will contribute to evaluate the quality control of the Brazilian herbaceous trade and also will assist to identify which parts of the medicinal plants has greater therapeutic effect.

  18. Routine use of microarray-based gene expression profiling to identify patients with low cytogenetic risk acute myeloid leukemia: accurate results can be obtained even with suboptimal samples

    Directory of Open Access Journals (Sweden)

    de la Blétière Diane Raingeard

    2012-01-01

    Full Text Available Abstract Background Gene expression profiling has shown its ability to identify with high accuracy low cytogenetic risk acute myeloid leukemia such as acute promyelocytic leukemia and leukemias with t(8;21 or inv(16. The aim of this gene expression profiling study was to evaluate to what extent suboptimal samples with low leukemic blast load (range, 2-59% and/or poor quality control criteria could also be correctly identified. Methods Specific signatures were first defined so that all 71 acute promyelocytic leukemia, leukemia with t(8;21 or inv(16-AML as well as cytogenetically normal acute myeloid leukemia samples with at least 60% blasts and good quality control criteria were correctly classified (training set. The classifiers were then evaluated for their ability to assign to the expected class 111 samples considered as suboptimal because of a low leukemic blast load (n = 101 and/or poor quality control criteria (n = 10 (test set. Results With 10-marker classifiers, all training set samples as well as 97 of the 101 test samples with a low blast load, and all 10 samples with poor quality control criteria were correctly classified. Regarding test set samples, the overall error rate of the class prediction was below 4 percent, even though the leukemic blast load was as low as 2%. Sensitivity, specificity, negative and positive predictive values of the class assignments ranged from 91% to 100%. Of note, for acute promyelocytic leukemia and leukemias with t(8;21 or inv(16, the confidence level of the class assignment was influenced by the leukemic blast load. Conclusion Gene expression profiling and a supervised method requiring 10-marker classifiers enable the identification of favorable cytogenetic risk acute myeloid leukemia even when samples contain low leukemic blast loads or display poor quality control criterion.

  19. GC profiles of volatile constituents from human urine obtained by closed loop stripping, purge and trap technique and simultaneous stem distillation-extraction.

    Science.gov (United States)

    Bestmann, H J; Haberkorn, K; Vostrowsky, O; Ferstl, R; Eggert, F

    1996-01-01

    Different techniques like "closed loop stripping" [CLSA], "purge and trap" [PTI], and continuous steam distillation extraction [SDE] were used to establish GC profiles of major histocompatibility complex-associated volatile constituents of human urine and statistically evaluated for reliability. Of the three methods investigated, PTI appeared to be superior for the detection of very volatile substances, whereas SDE was the most efficient one with respect to yield. A number of short to medium-chain ketones, 4-hydroxy-3-methoxy-styrene, menthol and nicotine were identified in preliminary analyses.

  20. Quantitative reconstruction of Ta/Si multilayer depth profiles obtained by Time-of-Flight-Secondary-Ion-Mass-Spectrometry (ToF-SIMS) using Cs{sup +} ion sputtering

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Y. [Department of Physics, Shantou University, 243 Daxue Road, Shantou, 515063 Guangdong (China); Hofmann, S. [Max Planck Institute for Intelligent Systems (formerly MPI for Metals Research), Heisenbergstrasse 3, D-70569 Stuttgart (Germany); Wang, J.Y., E-mail: wangjy@stu.edu.cn [Department of Physics, Shantou University, 243 Daxue Road, Shantou, 515063 Guangdong (China); Chakraborty, B.R. [Sophisticated Instrumentation Division, CSIR-National Physical Laboratory, Dr.K.S. Krishnan Road, New Delhi 110012 (India)

    2015-09-30

    Measured sputter depth profiles of Ta/Si multilayers consisting of 10 alternating layers of Si (10.5 nm thickness) and Ta (7.5 nm thickness) obtained by sputtering with Cs{sup +} ions of 1 keV energy, impinging under an angle of 45°, were re-evaluated by application of the Mixing-Roughness-Information depth (MRI) model for profile reconstruction. To be able to perform the latter, a decrease of the sputtering rate with sputtered depth, a strong and sputtering time dependent matrix effect of the detected Si{sup +} ion intensity as well as preferential sputtering of Si have to be taken into account. The results disclose a similar depth resolution for the Si and Ta layers composed of atomic mixing and roughness contributions. The depth resolution increases with the sputtered depth from 4.2 to 6.8 nm at 50 and 300 s sputtering time, respectively. Except for the first and the last two layers (Nos. 19 and 20), by application of the MRI model a full reconstruction of the measured profiles of the Si and Ta multilayer structure was obtained with a mean error of about ± 5%. - Highlights: • Full MRI model quantification of ToF-SIMS multilayer profiles • Correction for matrix effect and depth dependent sensitivity factor • Correction for composition dependent preferential sputtering effect • Profile representation in true depth scale coordinates based on correction 3 • Disclosing depth dependent depth resolution by atomic mixing and roughness components.

  1. Influence of the Laser Spot Size, Focal Beam Profile, and Tissue Type on the Lipid Signals Obtained by MALDI-MS Imaging in Oversampling Mode

    Science.gov (United States)

    Wiegelmann, Marcel; Dreisewerd, Klaus; Soltwisch, Jens

    2016-12-01

    To improve the lateral resolution in matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) beyond the dimensions of the focal laser spot oversampling techniques are employed. However, few data are available on the effect of the laser spot size and its focal beam profile on the ion signals recorded in oversampling mode. To investigate these dependencies, we produced 2 times six spots with dimensions between 30 and 200 μm. By optional use of a fundamental beam shaper, square flat-top and Gaussian beam profiles were compared. MALDI-MSI data were collected using a fixed pixel size of 20 μm and both pixel-by-pixel and continuous raster oversampling modes on a QSTAR mass spectrometer. Coronal mouse brain sections coated with 2,5-dihydroxybenzoic acid matrix were used as primary test systems. Sizably higher phospholipid ion signals were produced with laser spots exceeding a dimension of 100 μm, although the same amount of material was essentially ablated from the 20 μm-wide oversampling pixel at all spot size settings. Only on white matter areas of the brain these effects were less apparent to absent. Scanning electron microscopy images showed that these findings can presumably be attributed to different matrix morphologies depending on tissue type. We propose that a transition in the material ejection mechanisms from a molecular desorption at large to ablation at smaller spot sizes and a concomitant reduction in ion yields may be responsible for the observed spot size effects. The combined results indicate a complex interplay between tissue type, matrix crystallization, and laser-derived desorption/ablation and finally analyte ionization.

  2. Compositional Shift in Fatty Acid Profiles of Lipids Obtained from Oleaginous Yeasts upon the Addition of Essential Oil from Citrus sinensis L.

    Science.gov (United States)

    Uprety, Bijaya K; Rakshit, Sudip K

    2017-12-01

    Tailoring lipids from oleaginous yeasts to contain specific types of fatty acid is of considerable interest to food, fuel, and pharmaceutical industries. In this study, the essential oil obtained from Citrus sinesus L. has been used to alter the fatty acid composition of two common oleaginous yeasts, Rhodosporidium toruloides and Cryptococcus curvatus. With increasing levels of essential oil in the medium, the metabolic flux of the fatty acid biosynthesis pathway shifted towards saturated fatty acid production. Essential oil reduced the activities of elongase and ∆9 desaturase. This made the lipid obtained from both these yeasts rich in saturated fatty acids. At certain specific concentrations of the essential oil in the medium, the lipid obtained from R. toruloides and C. curvatus cultures was similar to mahuwa butter and palm oil, respectively. Limonene is the major constituents of orange essential oil. Its effect on one of the oleaginous yeasts, R. toruloides, was also studied separately. Effects similar to orange essential oil were obtained with limonene. Thus, we can conclude that limonene in orange essential oil brings about compositional change of microbial lipid produced in this organism.

  3. Apgar Scores

    Science.gov (United States)

    ... Stages Listen Español Text Size Email Print Share Apgar Scores Page Content Article Body As soon as ... baby's general condition at birth. What Does the Apgar Test Measure? The test measures your baby's: Heart ...

  4. HPLC-DAD-ESI-MS(2) analytical profile of extracts obtained from purple sweet potato after green ultrasound-assisted extraction.

    Science.gov (United States)

    Zhu, Zhenzhou; Guan, Qingyan; Koubaa, Mohamed; Barba, Francisco J; Roohinejad, Shahin; Cravotto, Giancarlo; Yang, Xinsun; Li, Shuyi; He, Jingren

    2017-01-15

    Ultrasound pre-treatment (UAE) was applied to assist the extraction of valuable compounds (polyphenols (especially anthocyanins), and proteins) from purple sweet potato (PSP). Under optimum conditions (ultrasound time (40min); supplementary hot extraction (80°C) up to 120min; pH: 2.5; ethanol concentration: 58%), the highest concentrations of polyphenols (3.877mg/g), anthocyanins (0.293mg/g), and proteins (0.753mg/g) were found, with minimal specific energy consumption (8406J/mg). Moreover, anthocyanin and non-anthocyanin polyphenols in PSP extract from optimized extraction temperature were identified using HPLC-DAD-ESI-MS(2). The major identified anthocyanins were peonidin-3-caffeoyl-p-hydroxybenzoyl sophoroside-5-glucoside, peonidin-3-(6″-caffeoyl-6‴-feruloyl sophoroside)-5-glucoside, cyanidin-3-caffeoyl-p-hydroxybenzoyl sophoroside-5-glucoside, whereas the major identified non-anthocyanin molecules were quinic acid, chlorogenic acid, caffeic acid, and chlorogenic acid-3-glucose. The amount of the predominant anthocyanin and non-anthocyanin compounds from PSP extract obtained after UAE was higher than that extracted after conventional solvent extraction. The results obtained in this work demonstrated the efficiency of UAE for the recovery of anthocyanins from PSP. Copyright © 2016 Elsevier Ltd. All rights reserved.

  5. A five-factor biomarker profile obtained week 4-12 of treatment for improved prognostication in metastatic renal cell carcinoma

    DEFF Research Database (Denmark)

    Soerensen, Anne V; Geertsen, Poul F; Christensen, Ib J

    2015-01-01

    BACKGROUND: Several biomarkers of treatment efficacy have been associated with a better prognosis in patients with metastatic renal cell carcinoma (mRCC). The prognostic significance of biomarkers in the early treatment phase is unclear. MATERIAL AND METHODS: In a complete national cohort of m......RCC patients receiving first-line tyrosine kinase inhibitors (TKI) or interleukin-2 based immunotherapy (IT) from 2006 to 2010, overall survival (OS) was analysed for baseline International mRCC Database Consortium (IMDC) classification factors and on-treatment time-dependent biomarkers obtained day 1 each...... cycle week 4-12 after treatment initiation with multivariate analysis and bootstrap validation. RESULTS: A total of 735 patients received first-line TKI (59%) or IT (41%). Median OS was overall 14.0 months and 33.4, 18.5, and 5.8 months for baseline IMDC favourable, intermediate, and poor risk groups...

  6. Protein profiles of Taenia solium cysts obtained from skeletal muscles and the central nervous system of pigs: Search for tissue-specific proteins.

    Science.gov (United States)

    Navarrete-Perea, José; Moguel, Bárbara; Bobes, Raúl José; Villalobos, Nelly; Carrero, Julio César; Sciutto, Edda; Soberón, Xavier; Laclette, Juan Pedro

    2017-01-01

    Taeniasis/cysticercosis caused by the tapeworm Taenia solium is a parasite disease transmitted among humans and pigs, the main intermediate host. The larvae/cysts can lodge in several tissues of the pig, i.e. skeletal muscles and different locations of the central nervous system. The molecular mechanisms associated to tissue preferences of the cysts remain poorly understood. The major public health concern about this zoonosis is due to the human infections by the larval form in the central nervous system, causing a highly pleomorphic and debilitating disease known as neurocysticercosis. This study was aimed to explore the 2DE protein maps of T. solium cysts obtained from skeletal muscles and central nervous system of naturally infected pigs. The gel images were analyzed through a combination of PDQuest™ and multivariate analysis. Results showed that differences in the protein patterns of cysts obtained from both tissues were remarkably discrete. Only 7 protein spots were found specifically associated to the skeletal muscle localization of the cysts; none was found significantly associated to the central nervous system. The use of distinct protein fractions of cysts allowed preliminary identification of several tissue-specific antigenic bands. The implications of these findings are discussed, as well as several strategies directed to achieve the complete characterization of this parasite's proteome, in order to extend our understanding of the molecular mechanisms underlying tissue localization of the cysts and to open avenues for the development of immunological tissue-specific diagnosis of the disease. Copyright © 2016 Elsevier Inc. All rights reserved.

  7. Optical Analysis of the Oils Obtained from Acrocomia aculeata (Jacq. Lodd: Mapping Absorption-Emission Profiles in an Induced Oxidation Process

    Directory of Open Access Journals (Sweden)

    Ivan P. de Oliveira

    2017-01-01

    Full Text Available Acrocomia aculeata is a palm tree typical of the Brazilian savanna. Oils extracted from the pulp and kernel of Acrocomia aculeata fruits have gained considerable attention mainly due to their nutritional and medicinal features. Despite their potential applications, a detailed analysis of their oxidative stability is still needed. The present study shows a close analysis of the oxidative stability of the oils obtained from the kernel and pulp of Acrocomia aculeata fruits, evaluating the influence of the intrinsic antioxidants and the fatty acid composition on the oil’s thermal stability. A complete characterization of the physical-chemical and optical properties of the oils was performed. The results showed that 66% of the fatty acids present in the pulp oil are unsaturated, while 75% are saturated in the kernel oil. A higher content of intrinsic antioxidants was obtained in the pulp oil, and an induction period (at 110 °C of 65 and 43 h was determined for the pulp and kernel oil, respectively. Additionally, oil absorption increases due to the formation of degradation products, and a new fluorescent compound was formed during the oil oxidation process at 110 °C. Even though the pulp presented a high content of unsaturated fatty acids, the pulp oil was more stable than the kernel oil due to its higher content of intrinsic antioxidant, especially carotenoids. The results also demonstrated that oil oxidation can be optically determined by analyzing the absorption at 232 and 270 nm, as well as the emission at 424 nm.

  8. Detection and validation of unscalable item score patterns using Item Response Theory: An illustration with Harter's Self-Perception Profile for Children

    NARCIS (Netherlands)

    Meijer, R.R.; Egberink, I.J.L.; Emons, Wilco H.M.; Sijtsma, Klaas

    2008-01-01

    We illustrate the usefulness of person-fit methodology for personality assessment. For this purpose, we use person-fit methods from item response theory. First, we give a nontechnical introduction to existing person-fit statistics. Second, we analyze data from Harter's (1985)Self-Perception Profile

  9. Field Aligned Currents Derived From Pressure Profiles Obtained From TWINS ENA Images for Geomagnetic Storms That Occurred On 01 June 2013 and 17 March 2015.

    Science.gov (United States)

    Wood, K.; Perez, J. D.; Goldstein, J.; McComas, D. J.; Valek, P. W.

    2016-12-01

    Field aligned currents (FACs) that flow from the Earth's magnetosphere into the ionosphere are an important coupling mechanism in the interaction of the solar wind with the Earth's magnetosphere and ionosphere. Assuming pressure balance and charge conservation yields an expression for the FACs in terms of plasma pressure gradients and pressure anisotropy. The Two Wide-angle Imaging Neutral Atom Spectrometers (TWINS) mission, the first stereoscopic ENA magnetospheric imager, provides global images of the inner magnetosphere from which ion pressure distributions and pressure anisotropies are obtained. Following the formulations in Vasyliunas (1970), Vasyliunas (1984), and Heinemann (1990), and using results from TWINS observations, we calculate the distributions of field aligned currents for geomagnetic storms on 1 June 2013 and 17 March 2015, in which extended ionospheric precipitation was observed. As previous work has assumed isotropic pressure distributions, we perform calculations both assuming pressure isotropy, and using the pressure anisotropy observed by TWINS, and compare the results from the two storms. References: 1. Vasyliunas, V. M. (1970). Mathematical Models of Magnetospheric Convection and its Coupling to the Ionosphere. Particles and Fields in the Magnetosphere Astrophysics and Space Science Library, 60-71. doi:10.1007/978-94-010-3284-1_6 2. Vasyliunas, V. M. (1984). Fundamentals of current description. Magnetospheric Currents Geophysical Monograph Series, 63-66. doi:10.1029/gm028p0063 3. Heinemann, M. (1990). Representations of currents and magnetic fields in anisotropic magnetohydrostatic plasma. J. Geophys. Res. Journal of Geophysical Research, 95(A6), 7789. doi:10.1029/ja095ia06p07789

  10. The application of dispersive liquid-liquid microextraction in the analyses of the fatty acid profile in bovine milk in response to changes in body condition score.

    Science.gov (United States)

    Quigley, Andrew; Connolly, Damian; Cummins, Wayne

    2018-01-15

    Dispersive liquid-liquid microextraction (DLLME) was used prior to gas chromatography flame ionization detection (GC-FID) for the extraction of five fatty acids from milk taken from cows with different body condition scores. Optimum extraction conditions were: 300 μL of chloroform (extraction solvent), and 1 mL methanol (dispersive solvent). The procedure was optimised using Design of Experiments (DoE). The analytes were separated on a GC capillary column containing a polyethylene glycol stationary phase (15 m × 0.53 mm × 1.2 μm). Enrichment factors were in the range of 8-15 and limit of detection (LOD) was 0.04 μg/mL. Calibration graphs showed good linearity with coefficients of determination higher than 0.994% and relative standard deviations lower than 7%. This method provided a simple and rapid derivatisation and extraction method for the determination of fatty acids in bovine milk. It showed that there was a significant difference in the palmitic acid content of milk from cows that had an optimum body condition score (10.85 mg/mL) compared to cows that had a high body condition score (5.73 mg/mL). Copyright © 2017 Elsevier B.V. All rights reserved.

  11. Comparison of cardiovascular risk factors and biochemical profile in patients with cardiac syndrome X and obstructive coronary artery disease: A propensity score-matched study

    OpenAIRE

    Vasheghani-Farahani, Ali; Nouri, Nasrin; Seifirad, Soroush; Sheikh Fathollahi, Mahmood; Hakki, Elham; Alidoosti, Mohammad; Davoodi, Gholamreza; Masoudkabir, Farzad; Poorhosseini, Hamidreza

    2013-01-01

    BACKGROUND This study was designed to compare the frequency of conventional cardiovascular disease risk factors and clinical biochemistry profile in patients with cardiac syndrome X (CSX) and obstructive coronary artery disease (CAD). METHODS A cross-sectional study was conducted on patients with typical angina and positive exercise tolerance test undergoing coronary angiography in our center. 342 consecutive patients with CSX were enrolled into this study and were matched regarding age and s...

  12. Real Time Extraction Kinetics of Electro Membrane Extraction Verified by Comparing Drug Metabolism Profiles Obtained from a Flow-Flow Electro Membrane Extraction-Mass Spectrometry System with LC-MS

    DEFF Research Database (Denmark)

    Fuchs, David; Jensen, Henrik; Pedersen-Bjergaard, Stig

    2015-01-01

    alternative to conventional protein precipitation followed by liquid chromatography-mass spectrometry (LC-MS) for studying drug metabolism. Comparison of EME-MS with LC-MS for drug metabolism analysis demonstrated for the first time that real time extraction of analytes by EME is possible. Metabolism kinetics...... were investigated for three different drugs: amitriptyline, promethazine, and methadone. By comparing the EME-MS extraction profiles of the drug substances and formed drug metabolites with the metabolism profiles obtained by conventional protein precipitation followed by LC-MS good correlation......A simple to construct and operate, "dip-in" electromembrane extraction (EME) probe directly coupled to electrospray ionization-mass spectrometry (ESI-MS) for rapid extraction and real time analysis of various analytes was developed. The setup demonstrated that EME-MS can be used as a viable...

  13. Hydraulic conductivity obtained by instantaneous profile method using retention curve and neutron probes and Genuchten model; Condutividade hidraulica obtida pelo metodo do perfil instantaneo utilizando curva de retencao e sonda de neutrons e pelo modelo de Genuchten

    Energy Technology Data Exchange (ETDEWEB)

    Berretta, Ana Lucia Olmedo

    1999-07-01

    The hydraulic conductivity is one of the most important parameters to understand the movement of water in the unsaturated zone. Reliable estimations are difficult to obtain, once the hydraulic conductivity is highly variable. This study was carried out at 'Escola Superior de Agricultura Luiz de Queiroz', Universidade de Sao Paulo, in a Kandiudalfic Eutrudox soil. The hydraulic conductivity was determined by a direct and an indirect method. The instantaneous profile method was described and the hydraulic conductivity as a function of soil water content was determined by solving the Richards equation. Tensiometers were used to estimate the total soil water potential, and the neutron probe and the soil retention curve were used to estimate soil water content in the direct method. The neutron probe showed to be not adequately sensible to the changes of soil water content in this soil. Despite of the soil retention curve provides best correlation values to soil water content as a function of water redistribution time, the soil water content in this soil did not vary too much till the depth of 50 cm, reflecting the influence of the presence of a Bt horizon. The soil retention curve was well fitted by the van Genuchten model used as an indirect method. The values of the van Genuchten and the experimental relative hydraulic conductivity obtained by the instantaneous profile method provided a good correlation. However, the values estimated by the model were always lower than that ones obtained experimentally. (author)

  14. Risk scores and geriatric profile: can they really help us in anticoagulation decision making among older patients suffering from atrial fibrillation?

    Science.gov (United States)

    Maes, Frédéric; Dalleur, Olivia; Henrard, Séverine; Wouters, Dominique; Scavée, Christophe; Spinewine, Anne; Boland, Benoit

    2014-01-01

    Anticoagulation for the prevention of cardio-embolism is most frequently indicated but largely underused in frail older patients with atrial fibrillation (AF). This study aimed at identifying characteristics associated with anticoagulation underuse. A cross-sectional study of consecutive geriatric patients aged ≥75 years, with AF and clear anticoagulation indication (CHADS₂ [Congestive heart failure, Hypertension, Age >75, Diabetes mellitus, and prior Stroke or transient ischemic attack] ≥2) upon hospital admission. All patients benefited from a comprehensive geriatric assessment. Their risks of stroke and bleeding were predicted using CHADS₂ and HEMORR2HAGES (Hepatic or renal disease, Ethanol abuse, Malignancy, Older (age >75 years), Reduced platelet count or function, Rebleed risk, Hypertension (uncontrolled), Anemia, Genetic factors, Excessive fall risk, and Stroke) scores, respectively. Anticoagulation underuse was observed in 384 (50%) of 773 geriatric patients with AF (median age 85 years; female 57%, cognitive disorder 33%, nursing home 20%). No geriatric characteristic was found to be associated with anticoagulation underuse. Conversely, anticoagulation underuse was markedly increased in the patients treated with aspirin (odds ratio [OR] [95% confidence interval]: 5.3 [3.8; 7.5]). Other independent predictors of anticoagulation underuse were ethanol abuse (OR: 4.0 [1.4; 13.3]) and age ≥90 years (OR: 2.0 [1.2; 3.4]). Anticoagulation underuse was not inferior in patients with a lower bleeding risk and/or a higher stroke risk and underuse was surprisingly not inferior either in the AF patients who had previously had a stroke. Half of this geriatric population did not receive any anticoagulation despite a clear indication, regardless of their individual bleeding or stroke risks. Aspirin use is the main characteristic associated with anticoagulation underuse.

  15. Obtención de modelo matemático para el desarrollo del perfil del ala de una aeronave. // Obtaining a mathematical model for the development of the profile of the airship wing.

    Directory of Open Access Journals (Sweden)

    R. Cabrera Pedroso

    2008-05-01

    Full Text Available El presente trabajo está dirigido a brindar un modelo matemático que permita el cálculo y determinación de una funciónanalítica para la obtención del perfil de un ala de geometría simétrica y variable de una aeronave con el empleo de métodoscomputacionales. En el artículo se analiza los métodos para la elaboración de sistemas de cálculo basados en modelosmatemáticos obtenidos en MATLAB 7.0 e implementados con el software LabVIEW 6.0 a través de programas de diseñosasistidos por computadoras en AUTOCAD (AUTOLISP. Los diferentes tópicos abordados dan a los interesados una ideaglobal del desarrollo de esta tecnología computacional y su aplicación a ramas de la mecánica, así como la metodologíaseguida para obtener el perfil aerodinámico de un ala. También se exponen aspectos generales del empleo de la funciónAUTOLISP y el código fuente del programa diseñado.Palabras claves: perfil de alas, modelos matemáticos, AutoCAD, AutoLISP, medición experimental.__________________________________________________________________________Abstract.This article was carried out to obtain a mathematical model that allows the calculation and determination of an analyticfunction of symmetrical geometry profile and variable. In the article it is analyzed the methods for the elaboration ofsystem of calculations based on mathematical models obtained with the software language LabVIEW 6.0 and it is used todeveloping the program attended by the computers AUTOCAD (AUTOLISP. The approached topics give to the interestedparties a global idea of the development it gives this technology and their application to branches of the mechanicalspecialties, as well as the followed methodology to obtain the aerofoil profile of a wing. General aspects are also exposedof the employment of the function AUTOLISP and the source code on the sketch program.Key words: Wing profiles, mathematical models, AutoCAD, AutoLISP, experimental measurement.

  16. Dissolved inorganic carbon, alkalinity, temperature, salinity and other variables collected from discrete sample and profile observations using CTD, bottle and other instruments obtained during the R/V Discovery EEL_2011_D365 Cruise Along Extended Ellett Line from 2011-05-20 to 2011-05-31 (NCEI Accession 0157258)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — NCEI Accession 0157258 includes chemical, discrete sample, physical and profile data obtained during the R/V Discovery EEL_2011_D365 Cruise Along Extended Ellett...

  17. Dose profile for electron beams obtained with CaSO{sub 4}:Ce,Eu thermoluminescent dosimeters; Perfil de dose de feixes de eletrons obtidos com dosimetros termoluminescentes de CaSO{sub 4}:Ce,Eu

    Energy Technology Data Exchange (ETDEWEB)

    Nunes, Maira G.; Rodrigues, Leticia L.C., E-mail: mgnunes@ipen.br [Instituto de Pesquisas Energerticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2012-12-15

    The calcium sulphate activated with cerium and europium (CaSO{sub 4}:Ce,Eu) thermoluminescent dosimeters (TLD) recently developed at Nuclear and Energy Research Institute as well as the calcium sulphate activated with dysprosium (CaSO{sub 4}: Dy) and lithium fluoride activated with magnesium and titanium, (LiF:Mg,Ti; TLD-100) TLDs, with long term applications in dosimetry and considered as standards, were used to obtain the dose profile for 3.43, 5.48, 8.27 and 11.67 MeV electron beams generated by a linear accelerator Clinac 2100-C (Varian) in the reference conditions defined by the TRS-398 code of practice. The routine dosimetry of the electron beams, performed with a calibrated ionization chamber, ensures that the electron beams fulfill the requirements of flatness and symmetry established in this code of practice. Thus, as the TRS-398 Code of Practice requirements are fulfilled by the measurements performed with the new TLD type, CaSO{sub 4}:Ce,Eu may be applied in clinical dosimetry of high energy electron beams. (author)

  18. Competitive Cooperation: The Iceberg Profile.

    Science.gov (United States)

    Vaughan, Jerry L.

    Competitive athletes' scores on the Profile of Mood States (POMS) test create an iceberg-like pattern known as the "Iceberg Profile." Their scores for tension, depression, anger, fatigue, and confusion are low while their scores on vigor juts upward creating the "Iceberg Profile." Persons in a cooperative relationship are often…

  19. Pavement scores synthesis.

    Science.gov (United States)

    2009-02-01

    The purpose of this synthesis was to summarize the use of pavement scores by the states, including the : rating methods used, the score scales, and descriptions; if the scores are used for recommending pavement : maintenance and rehabilitation action...

  20. Obtaining of inulin acetate

    OpenAIRE

    Khusenov, Arslonnazar; Rakhmanberdiev, Gappar; Rakhimov, Dilshod; Khalikov, Muzaffar

    2014-01-01

    In the article first obtained inulin ester inulin acetate, by etherification of inulin with acetic anhydride has been exposed. Obtained product has been studied using elementary analysis and IR spectroscopy.

  1. Evaluation of body mass index and plasma lipid profile in dogs ...

    African Journals Online (AJOL)

    This study evaluated the body mass index (BMI), plasma lipid profile and gait assessment score (GAS) in dogs. Body weights (BW), height (H) at shoulder and waist circumference (WC) were obtained from fifty client-owned dogs of both sexes to determine the BMI. In addition, body condition score (BCS) and GAS were ...

  2. Scoring nail psoriasis

    NARCIS (Netherlands)

    Klaassen, K.M.G.; Kerkhof, P.C.M. van de; Bastiaens, M.T.; Plusje, L.G.; Baran, R.L.; Pasch, M.C.

    2014-01-01

    BACKGROUND: Scoring systems are indispensable in evaluating the severity of disease and monitoring treatment response. OBJECTIVE: We sought to evaluate the competence of various nail psoriasis severity scoring systems and to develop a new scoring system. METHODS: The authors conducted a prospective,

  3. Commercial Building Energy Asset Score

    Energy Technology Data Exchange (ETDEWEB)

    2017-05-26

    This software (Asset Scoring Tool) is designed to help building owners and managers to gain insight into the as-built efficiency of their buildings. It is a web tool where users can enter their building information and obtain an asset score report. The asset score report consists of modeled building energy use (by end use and by fuel type), building systems (envelope, lighting, heating, cooling, service hot water) evaluations, and recommended energy efficiency measures. The intended users are building owners and operators who have limited knowledge of building energy efficiency. The scoring tool collects minimum building data (~20 data entries) from users and build a full-scale energy model using the inference functionalities from Facility Energy Decision System (FEDS). The scoring tool runs real-time building energy simulation using EnergyPlus and performs life-cycle cost analysis using FEDS. An API is also under development to allow the third-party applications to exchange data with the web service of the scoring tool.

  4. Perfil de beta talassemia heterozigota obtido a partir de análise data mining em banco de dados The profile of beta thalassemia obtained by data mining analysis in a database

    Directory of Open Access Journals (Sweden)

    Ana L. B. Domingos

    2010-02-01

    Full Text Available Variations in the phenotypic expression of heterozygous beta thalassemia reflect the formation of different populations. To better understand the profile of heterozygous beta-thalassemia of the Brazilian population, we aimed at establishing parameters to direct the diagnosis of carriers and calculate the frequency from information stored in an electronic database. Using a Data Mining tool, we evaluated information on 10,960 blood samples deposited in a relational database. Over the years, improved diagnostic technology has facilitated the elucidation of suspected beta thalassemia heterozygote cases with an average frequency of 3.5% of referred cases. We also found that the Brazilian beta thalassemia trait has classic increases of Hb A2 and Hb F (60%, mainly caused by mutations in beta zero thalassemia, especially in the southeast of the country.

  5. Confidence scores for prediction models

    DEFF Research Database (Denmark)

    Gerds, Thomas Alexander; van de Wiel, MA

    2011-01-01

    modelling strategy is applied to different training sets. For each modelling strategy we estimate a confidence score based on the same repeated bootstraps. A new decomposition of the expected Brier score is obtained, as well as the estimates of population average confidence scores. The latter can be used......In medical statistics, many alternative strategies are available for building a prediction model based on training data. Prediction models are routinely compared by means of their prediction performance in independent validation data. If only one data set is available for training and validation......, then rival strategies can still be compared based on repeated bootstraps of the same data. Often, however, the overall performance of rival strategies is similar and it is thus difficult to decide for one model. Here, we investigate the variability of the prediction models that results when the same...

  6. Phytochemical profile and mechanisms involved in the anti-nociception caused by the hydroethanolic extract obtained from Tocoyena formosa (Cham. & Schltdl.) K. Schum (Jenipapo-bravo) leaves in mice.

    Science.gov (United States)

    Cesário, Francisco Rafael Alves Santana; de Albuquerque, Thaís Rodrigues; de Lacerda, Giovana Mendes; de Oliveira, Maria Rayane Correia; Rodrigues, Lindaiane Bezerra; Martins, Anita Oliveira Brito Pereira Bezerra; Boligon, Aline Augusti; Júnior, Lucindo José Quintans; de Souza Araújo, Adriano Antunes; Vale, Mariana Lima; Coutinho, Henrique Douglas Melo; de Menezes, Irwin Rose Alencar

    2018-01-01

    Tocoyena formosa, a small ornamental tree growing in the dry regions of central Brazil, is commonly known as 'genipapo do bravo'. This is a medicinal plant traditionally used as an analgesic for rheumatic pain, lower back pain and myalgia, however its use is carried out without scientific evidence, which thus justifies the development of studies to investigate and prove its therapeutic potential. Therefore, the objective of this study was to evaluate the phytochemical profile of Tocoyena formosa (Cham. & Schlecht.) K. Schum (TFLHE) and the mechanisms involved in its anti-nociceptive effect. The TFLHE revealed the presence of gallic acid, catechin, chlorogenic acid, caffeic acid, ellagic acid, rutin, quercetin and luteolin. The TFLHE at doses of 200 and 400mg/kg significantly decreased acetic acid-induced abdominal contortions, the reaction time for the formalin test in both phases and increased the paw withdrawal time in the hot plate thermal stimulus test. The 200mg/kg dose also significantly inhibited the plantar mechanical hyperalgesia intensity induced by formalin within 24h. with the TFLHE did not cause significant changes in motor performance and coordination in the Rota Rod test. The investigation on the possible mechanism of antinociceptive action of TFLHE indicates the involvement of opioid, glutamatergic, nitric oxide/cGMP and vanilloid systems. It is concluded that the TFLHE has an antinociceptive effect promoted by the aforementioned mechanisms. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  7. Evaluation of body mass index and plasma lipid profile in Boerboel ...

    African Journals Online (AJOL)

    This study evaluated the body mass index (BMI) and plasma lipid profile in Boerboel dogs. Body weights (BW), height (H) at shoulder and waist circumference (WC) were obtained from fifty-three Boerboels to determine the BMI while, body condition score (BCS) was determined subjectively. Also 5mls of blood was obtained ...

  8. [Erythromycin ethylsuccinate obtaining possibilities].

    Science.gov (United States)

    Stan, Cătălina Daniela; Stefanache, Alina; Tântaru, Gladiola; Poiată, Antonia; Dumitrache, M; Diaconu, D E; Profire, Lenuţa

    2008-01-01

    In this study we tried to improve the erythromycin ethylsuccinate obtaining, having in view to separate the erythromycin ester by crystallization in water. The erythromycin acylation and the erythromycin ethylsuccinate crystallization were realized, following the next steps: 1. the acylation of the erythromycin with a methylene chloride solution of monoethylsuccinyl chloride, at 25-28 degrees C for 3 hours in the presence of NaHCO3; 2. the transfer of the erythromycin ethylsuccinate from methylene chloride solution in acetone solution by distillation of mixture methylene chloride: acetone 1:1 at 25-28 degrees C; 3. erythromycin ethylsuccinate separation by crystallization in water at pH = 8-8.5 and 5 degrees C for 90 minutes. The quality control for the erythromycin ester was performed according to the Xth edition of Romanian Pharmacopoeia standards using national standard for erythromycin ethylsuccinate and national standard for erythromycin with an activity of 1: 937 U and 2.02% humidity. The Micrococcus luteus ATCC 9341 was used as a test microorganism and a thin layer cromatography was performed for qualitative control. 13.1 g of erythromycin ethylsuccinate were obtained with an output of the process of 82.02%. Using water for the separation of erythromycin ethylsuccinate the output of the process is greater (82.02%) than in case of using petroleum ether (74.14%) or hexane (80.25%). The thin layer cromatography revealed an Rf = 0.56 and the microbiological activity of the erythromycin ethylsuccinate was 98.7% compared with the standard. Using water instead of hexane or petroleum ether is gainful for the separation of erythromycin ethylsuccinate from the reaction medium. The obtained erythromycin ethylsuccinate corresponds to the Xth edition of Romanian Pharmacopoeia standards. So, the raw materials consumption is decreased, the costs are cut down, the obtained product purity is high and the output of the process is greater.

  9. Modifying scoring system at South African University rugby level ...

    African Journals Online (AJOL)

    Success in rugby is measured by winning the game and in order to do so, teams need to score more points than the opposing team. The primary aim of this study was to investigate and compare the scoring profile of the 2011 and 2012 tournaments and to determine if modifying the scoring system at South African University ...

  10. SCORE - A DESCRIPTION.

    Science.gov (United States)

    SLACK, CHARLES W.

    REINFORCEMENT AND ROLE-REVERSAL TECHNIQUES ARE USED IN THE SCORE PROJECT, A LOW-COST PROGRAM OF DELINQUENCY PREVENTION FOR HARD-CORE TEENAGE STREET CORNER BOYS. COMMITTED TO THE BELIEF THAT THE BOYS HAVE THE POTENTIAL FOR ETHICAL BEHAVIOR, THE SCORE WORKER FOLLOWS B.F. SKINNER'S THEORY OF OPERANT CONDITIONING AND REINFORCES THE DELINQUENT'S GOOD…

  11. The Apgar Score.

    Science.gov (United States)

    2015-10-01

    The Apgar score provides an accepted and convenient method for reporting the status of the newborn infant immediately after birth and the response to resuscitation if needed. The Apgar score alone cannot be considered as evidence of, or a consequence of, asphyxia; does not predict individual neonatal mortality or neurologic outcome; and should not be used for that purpose. An Apgar score assigned during resuscitation is not equivalent to a score assigned to a spontaneously breathing infant. The American Academy of Pediatrics and the American College of Obstetricians and Gynecologists encourage use of an expanded Apgar score reporting form that accounts for concurrent resuscitative interventions. Copyright © 2015 by the American Academy of Pediatrics.

  12. The role of titanium oxide concentration profile of titanium oxide of RuO2-TiO2 coatings obtained by the sol-gel procedure on its electrochemical behavior

    Directory of Open Access Journals (Sweden)

    VLADIMIR V. PANIC

    2003-12-01

    Full Text Available In order to understand the role of TiO2 in the deactivation mechanism of an active RuO2–TiO2 coating, an additional TiO2 layer was introduced in the support|coating interphase of regular Ti//[RuO2–TiO2] anode in one case and on the surface of the coating in the other. The electrochemical behavior of these, with TiO2 enriched, anodes was compared with the behavior of anodes with regular RuO2–TiO2 coatings, which were subjected to an accelerated stability test. A high-frequency semicircle in the complex plane plot, obtained by electrochemical impedance spectroscopy, for a regular RuO2–TiO2 coating corresponds to TiO2 enrichment in the coating as a consequence of anode corrosion. In the case of the coatings with additional TiO2 layers, a high-frequency semicircle was not observed. The additional TiO2 layers increase the coating overall resistance and influence the coating impedance behavior at low frequencies. Similar equivalent electrical circuits were used to analyze the impedance behavior of coatings having an additional TiO2 layer at different position within RuO2–TiO2 coating.

  13. Performance of an Automated Polysomnography Scoring System Versus Computer-Assisted Manual Scoring

    Science.gov (United States)

    Malhotra, Atul; Younes, Magdy; Kuna, Samuel T.; Benca, Ruth; Kushida, Clete A.; Walsh, James; Hanlon, Alexandra; Staley, Bethany; Pack, Allan I.; Pien, Grace W.

    2013-01-01

    Study Objectives: Manual scoring of polysomnograms (PSG) is labor intensive and has considerable variance between scorers. Automation of scoring could reduce cost and improve reproducibility. The purpose of this study was to compare a new automated scoring system (YST-Limited, Winnipeg, Canada) with computer-assisted manual scoring. Design: Technical assessment. Setting: Five academic medical centers. Participants: N/A. Interventions: N/A. Measurements and Results: Seventy PSG files were selected at University of Pennsylvania (Penn) and distributed to five US academic sleep centers. Two blinded technologists from each center scored each file. Automatic scoring was performed at Penn by a YST Limited technician using a laptop containing the software. Variables examined were sleep stages, arousals, and apnea-hypopnea index (AHI) using three methods of identifying hypopneas. Automatic scores were not edited and were compared to the average scores of the 10 technologists. Intraclass correlation coefficient (ICC) was obtained for the 70 pairs and compared to across-sites ICCs for manually scored results. ICCs for automatic versus manual scoring were > 0.8 for total sleep time, stage N2, and nonrapid eye movement arousals and > 0.9 for AHI scored by primary and secondary American Academy of Sleep Medicine criteria. ICCs for other variables were not as high but were comparable to the across-site ICCs for manually scored results. Conclusion: The automatic system yielded results that were similar to those obtained by experienced technologists. Very good ICCs were obtained for many primary PSG outcome measures. This automated scoring software, particularly if supplemented with manual editing, may increase laboratory efficiency and standardize PSG scoring results within and across sleep centers. Citation: Malhotra A; Younes M; Kuna ST; Benca R; Kushida CA; Walsh J; Hanlon A; Staley B; Pack AI; Pien GW. Performance of an automated polysomnography scoring system versus computer

  14. The Bandim tuberculosis score

    DEFF Research Database (Denmark)

    Rudolf, Frauke; Joaquim, Luis Carlos; Vieira, Cesaltina

    2013-01-01

    Background: This study was carried out in Guinea-Bissau ’ s capital Bissau among inpatients and outpatients attending for tuberculosis (TB) treatment within the study area of the Bandim Health Project, a Health and Demographic Surveillance Site. Our aim was to assess the variability between 2...... physicians in performing the Bandim tuberculosis score (TBscore), a clinical severity score for pulmonary TB (PTB), and to compare it to the Karnofsky performance score (KPS). Method : From December 2008 to July 2009 we assessed the TBscore and the KPS of 100 PTB patients at inclusion in the TB cohort and...

  15. Volleyball Scoring Systems.

    Science.gov (United States)

    Calhoun, William; Dargahi-Noubary, G. R.; Shi, Yixun

    2002-01-01

    The widespread interest in sports in our culture provides an excellent opportunity to catch students' attention in mathematics and statistics classes. One mathematically interesting aspect of volleyball, which can be used to motivate students, is the scoring system. (MM)

  16. Early warning scores.

    Science.gov (United States)

    2012-09-27

    A free app available from the Apple App Store is aimed at supporting health professionals in Wales to use the National Early Warning Score (NEWS). The tool helps staff identify patients who are developing serious illness.

  17. Obtaining Your License: Careers in Real Estate.

    Science.gov (United States)

    Lyon, Robert

    Two steps are required to obtain a real estate salesperson's license in Texas: (1) selecting a broker to serve as an advisor, and (2) meeting personal requirements (at least 18 years old, a Texas resident, completion of a minimum of 12 semester hours of real estate and related courses, application, acceptable score on state exam, and payment of…

  18. A 19-SNP coronary heart disease gene score profile in subjects with type 2 diabetes: the coronary heart disease risk in type 2 diabetes (CoRDia study) study baseline characteristics.

    Science.gov (United States)

    Beaney, Katherine E; Ward, Claire E; Bappa, Dauda A S; McGale, Nadine; Davies, Anna K; Hirani, Shashivadan P; Li, KaWah; Howard, Philip; Vance, Dwaine R; Crockard, Martin A; Lamont, John V; Newman, Stanton; Humphries, Steve E

    2016-10-03

    The coronary risk in diabetes (CoRDia) trial (n = 211) compares the effectiveness of usual diabetes care with a self-management intervention (SMI), with and without personalised risk information (including genetics), on clinical and behavioural outcomes. Here we present an assessment of randomisation, the cardiac risk genotyping assay, and the genetic characteristics of the recruits. Ten-year coronary heart disease (CHD) risk was calculated using the UKPDS score. Genetic CHD risk was determined by genotyping 19 single nucleotide polymorphisms (SNPs) using Randox's Cardiac Risk Prediction Array and calculating a gene score (GS). Accuracy of the array was assessed by genotyping a subset of pre-genotyped samples (n = 185). Overall, 10-year CHD risk ranged from 2-72 % but did not differ between the randomisation groups (p = 0.13). The array results were 99.8 % concordant with the pre-determined genotypes. The GS did not differ between the Caucasian participants in the CoRDia SMI plus risk group (n = 66) (p = 0.80) and a sample of UK healthy men (n = 1360). The GS was also associated with LDL-cholesterol (p = 0.05) and family history (p = 0.03) in a sample of UK healthy men (n = 1360). CHD risk is high in this group of T2D subjects. The risk array is an accurate genotyping assay, and is suitable for estimating an individual's genetic CHD risk. Trial registration This study has been registered at ClinicalTrials.gov; registration identifier NCT01891786.

  19. Instant MuseScore

    CERN Document Server

    Shinn, Maxwell

    2013-01-01

    Get to grips with a new technology, understand what it is and what it can do for you, and then get to work with the most important features and tasks. Instant MuseScore is written in an easy-to follow format, packed with illustrations that will help you get started with this music composition software.This book is for musicians who would like to learn how to notate music digitally with MuseScore. Readers should already have some knowledge about musical terminology; however, no prior experience with music notation software is necessary.

  20. The lod score method.

    Science.gov (United States)

    Rice, J P; Saccone, N L; Corbett, J

    2001-01-01

    The lod score method originated in a seminal article by Newton Morton in 1955. The method is broadly concerned with issues of power and the posterior probability of linkage, ensuring that a reported linkage has a high probability of being a true linkage. In addition, the method is sequential, so that pedigrees or lod curves may be combined from published reports to pool data for analysis. This approach has been remarkably successful for 50 years in identifying disease genes for Mendelian disorders. After discussing these issues, we consider the situation for complex disorders, where the maximum lod score (MLS) statistic shares some of the advantages of the traditional lod score approach but is limited by unknown power and the lack of sharing of the primary data needed to optimally combine analytic results. We may still learn from the lod score method as we explore new methods in molecular biology and genetic analysis to utilize the complete human DNA sequence and the cataloging of all human genes.

  1. Nursing activities score

    NARCIS (Netherlands)

    Miranda, DR; Nap, R; de Rijk, A; Schaufeli, W; Lapichino, G

    Objectives. The instruments used for measuring nursing workload in the intensive care unit (e.g., Therapeutic Intervention Scoring System-28) are based on therapeutic interventions related to severity of illness. Many nursing activities are not necessarily related to severity of illness, and

  2. Syncopation and the score.

    Directory of Open Access Journals (Sweden)

    Chunyang Song

    Full Text Available The score is a symbolic encoding that describes a piece of music, written according to the conventions of music theory, which must be rendered as sound (e.g., by a performer before it may be perceived as music by the listener. In this paper we provide a step towards unifying music theory with music perception in terms of the relationship between notated rhythm (i.e., the score and perceived syncopation. In our experiments we evaluated this relationship by manipulating the score, rendering it as sound and eliciting subjective judgments of syncopation. We used a metronome to provide explicit cues to the prevailing rhythmic structure (as defined in the time signature. Three-bar scores with time signatures of 4/4 and 6/8 were constructed using repeated one-bar rhythm-patterns, with each pattern built from basic half-bar rhythm-components. Our manipulations gave rise to various rhythmic structures, including polyrhythms and rhythms with missing strong- and/or down-beats. Listeners (N = 10 were asked to rate the degree of syncopation they perceived in response to a rendering of each score. We observed higher degrees of syncopation in time signatures of 6/8, for polyrhythms, and for rhythms featuring a missing down-beat. We also found that the location of a rhythm-component within the bar has a significant effect on perceived syncopation. Our findings provide new insight into models of syncopation and point the way towards areas in which the models may be improved.

  3. YOUNG ATHLETES' MOTIVATIONAL PROFILES

    Directory of Open Access Journals (Sweden)

    Juan Antonio Moreno Murcia

    2007-06-01

    Full Text Available The aim of this study was to examine the relationship between motivational characteristics and dispositional flow. In order to accomplish this goal, motivational profiles emerging from key constructs within Achievement Goal Theory and Self-Determination Theory were related to the dispositional flow measures. A sample of 413 young athletes (Age range 12 to 16 years completed the PMCSQ-2, POSQ, SMS and DFS measures. Cluster analysis results revealed three profiles: a "self-determined profile" characterised by higher scores on the task-involving climate perception and on the task orientation; a "non-self-determined profile", characterised by higher scores on ego-involving climate perception and ego orientation; and a "low self-determined and low non-self-determined profile" which had the lowest dispositional flow. No meaningful differences were found between the "self-determined profile" and the "non-self-determined profile" in dispositional flow. The "self-determined profile" was more commonly associated with females, athletes practising individual sports and those training more than three days a week. The "non-self-determined profile" was more customary of males and athletes practising team sports as well as those training just two or three days a week

  4. Investigating the Written Exam Scores' Prediction Power of TEOG Exam Scores

    Science.gov (United States)

    Kontas, Hakki; Özpolat, Esen Turan

    2017-01-01

    The purpose of this study was to investigate exam scores' predicting Transition from Primary to Secondary Education (TEOG) exam scores. The research data were obtained from the records of 1035 students studying at the first term of eighth grade in 2015-2016 academic year in e-school system. The research was on relational screening model. Linear…

  5. Score test variable screening

    OpenAIRE

    Zhao, Sihai Dave; Li, Yi

    2014-01-01

    Variable screening has emerged as a crucial first step in the analysis of high-throughput data, but existing procedures can be computationally cumbersome, difficult to justify theoretically, or inapplicable to certain types of analyses. Motivated by a high-dimensional censored quantile regression problem in multiple myeloma genomics, this paper makes three contributions. First, we establish a score test-based screening framework, which is widely applicable, extremely computationally efficient...

  6. Your Criminal Fico Score

    Science.gov (United States)

    2016-09-01

    Scores.” Journal of Applied Psychology 97(2012): 469–478. Chan, Janet, and Lyria Bennett Moses, “Is Big Data Challenging Criminology?” Theoretical...release. Distribution is unlimited. 12b. DISTRIBUTION CODE 13. ABSTRACT (maximum 200 words) One of the more contentious uses of big data ...analytics in homeland security is predictive policing, which harnesses big data to allocate police resources, decrease crime, and increase public safety

  7. Score test variable screening.

    Science.gov (United States)

    Zhao, Sihai Dave; Li, Yi

    2014-12-01

    Variable screening has emerged as a crucial first step in the analysis of high-throughput data, but existing procedures can be computationally cumbersome, difficult to justify theoretically, or inapplicable to certain types of analyses. Motivated by a high-dimensional censored quantile regression problem in multiple myeloma genomics, this article makes three contributions. First, we establish a score test-based screening framework, which is widely applicable, extremely computationally efficient, and relatively simple to justify. Secondly, we propose a resampling-based procedure for selecting the number of variables to retain after screening according to the principle of reproducibility. Finally, we propose a new iterative score test screening method which is closely related to sparse regression. In simulations we apply our methods to four different regression models and show that they can outperform existing procedures. We also apply score test screening to an analysis of gene expression data from multiple myeloma patients using a censored quantile regression model to identify high-risk genes. © 2014, The International Biometric Society.

  8. Your criminal FICO score

    OpenAIRE

    Tonelli, Michelle

    2016-01-01

    Approved for public release; distribution is unlimited One of the more contentious uses of big data analytics in homeland security is predictive policing, which harnesses big data to allocate police resources, decrease crime, and increase public safety. While predictive analytics has long been in use to forecast human behavior, the framework has not proved to be a flawless undertaking. In an effort to improve outcomes of predictive policing, this thesis assesses two high-profile programs—t...

  9. Family and academic performance: identifying high school student profiles

    Directory of Open Access Journals (Sweden)

    Alicia Aleli Chaparro Caso López

    2016-01-01

    Full Text Available The objective of this study was to identify profiles of high school students, based on variables related to academic performance, socioeconomic status, cultural capital and family organization. A total of 21,724 high school students, from the five municipalities of the state of Baja California, took part. A K-means cluster analysis was performed to identify the profiles. The analyses identified two clearly-defined clusters: Cluster 1 grouped together students with high academic performance and who achieved higher scores for socioeconomic status, cultural capital and family involvement, whereas Cluster 2 brought together students with low academic achievement, and who also obtained lower scores for socioeconomic status and cultural capital, and had less family involvement. It is concluded that the family variables analyzed form student profiles that can be related to academic achievement.

  10. Prognostic value of TIMI score versus GRACE score in ST-segment elevation myocardial infarction.

    Science.gov (United States)

    Correia, Luis C L; Garcia, Guilherme; Kalil, Felipe; Ferreira, Felipe; Carvalhal, Manuela; Oliveira, Ruan; Silva, André; Vasconcelos, Isis; Henri, Caio; Noya-Rabelo, Márcia

    2014-08-01

    The TIMI Score for ST-segment elevation myocardial infarction (STEMI) was created and validated specifically for this clinical scenario, while the GRACE score is generic to any type of acute coronary syndrome. Between TIMI and GRACE scores, identify the one of better prognostic performance in patients with STEMI. We included 152 individuals consecutively admitted for STEMI. The TIMI and GRACE scores were tested for their discriminatory ability (C-statistics) and calibration (Hosmer-Lemeshow) in relation to hospital death. The TIMI score showed equal distribution of patients in the ranges of low, intermediate and high risk (39 %, 27 % and 34 %, respectively), as opposed to the GRACE Score that showed predominant distribution at low risk (80 %, 13 % and 7%, respectively). Case-fatality was 11%. The C-statistics of the TIMI score was 0.87 (95%CI = 0.76 to 0.98), similar to GRACE (0.87, 95%CI = 0.75 to 0.99) - p = 0.71. The TIMI score showed satisfactory calibration represented by χ2 = 1.4 (p = 0.92), well above the calibration of the GRACE score, which showed χ2 = 14 (p = 0.08). This calibration is reflected in the expected incidence ranges for low, intermediate and high risk, according to the TIMI score (0 %, 4.9 % and 25 %, respectively), differently to GRACE (2.4%, 25% and 73%), which featured middle range incidence inappropriately. Although the scores show similar discriminatory capacity for hospital death, the TIMI score had better calibration than GRACE. These findings need to be validated populations of different risk profiles.

  11. Prognostic Value of TIMI Score versus GRACE Score in ST-segment Elevation Myocardial Infarction

    Directory of Open Access Journals (Sweden)

    Luis C. L. Correia

    2014-08-01

    Full Text Available Background: The TIMI Score for ST-segment elevation myocardial infarction (STEMI was created and validated specifically for this clinical scenario, while the GRACE score is generic to any type of acute coronary syndrome. Objective: Between TIMI and GRACE scores, identify the one of better prognostic performance in patients with STEMI. Methods: We included 152 individuals consecutively admitted for STEMI. The TIMI and GRACE scores were tested for their discriminatory ability (C-statistics and calibration (Hosmer-Lemeshow in relation to hospital death. Results: The TIMI score showed equal distribution of patients in the ranges of low, intermediate and high risk (39 %, 27 % and 34 %, respectively, as opposed to the GRACE Score that showed predominant distribution at low risk (80 %, 13 % and 7%, respectively. Case-fatality was 11%. The C-statistics of the TIMI score was 0.87 (95%CI = 0.76 to 0.98, similar to GRACE (0.87, 95%CI = 0.75 to 0.99 - p = 0.71. The TIMI score showed satisfactory calibration represented by χ2 = 1.4 (p = 0.92, well above the calibration of the GRACE score, which showed χ2 = 14 (p = 0.08. This calibration is reflected in the expected incidence ranges for low, intermediate and high risk, according to the TIMI score (0 %, 4.9 % and 25 %, respectively, differently to GRACE (2.4%, 25% and 73%, which featured middle range incidence inappropriately. Conclusion: Although the scores show similar discriminatory capacity for hospital death, the TIMI score had better calibration than GRACE. These findings need to be validated populations of different risk profiles.

  12. Forecast skill score assessment of a relocatable ocean prediction system, using a simplified objective analysis method

    Science.gov (United States)

    Onken, Reiner

    2017-11-01

    A relocatable ocean prediction system (ROPS) was employed to an observational data set which was collected in June 2014 in the waters to the west of Sardinia (western Mediterranean) in the framework of the REP14-MED experiment. The observational data, comprising more than 6000 temperature and salinity profiles from a fleet of underwater gliders and shipborne probes, were assimilated in the Regional Ocean Modeling System (ROMS), which is the heart of ROPS, and verified against independent observations from ScanFish tows by means of the forecast skill score as defined by Murphy(1993). A simplified objective analysis (OA) method was utilised for assimilation, taking account of only those profiles which were located within a predetermined time window W. As a result of a sensitivity study, the highest skill score was obtained for a correlation length scale C = 12.5 km, W = 24 h, and r = 1, where r is the ratio between the error of the observations and the background error, both for temperature and salinity. Additional ROPS runs showed that (i) the skill score of assimilation runs was mostly higher than the score of a control run without assimilation, (i) the skill score increased with increasing forecast range, and (iii) the skill score for temperature was higher than the score for salinity in the majority of cases. Further on, it is demonstrated that the vast number of observations can be managed by the applied OA method without data reduction, enabling timely operational forecasts even on a commercially available personal computer or a laptop.

  13. State Test Score Trends through 2008-09, Part 1: Rising Scores on State Tests and NAEP. Washington

    Science.gov (United States)

    Center on Education Policy, 2010

    2010-01-01

    This paper profiles Washington's test score trends through 2008-09. Between 2005 and 2009, the percentages of students reaching the proficient level on the state test and the basic level on NAEP (National Assessment of Educational Progress) decreased in grade 4 reading. In grade 4 math, the percentage scoring proficient on the state test decreased…

  14. Score lists in multipartite hypertournaments

    CERN Document Server

    Pirzada, Shariefuddin; Iványi, Antal

    2010-01-01

    Given non-negative integers $n_{i}$ and $\\alpha_{i}$ with $0 \\leq \\alpha_{i} \\leq n_i$ $(i=1,2,...,k)$, an $[\\alpha_{1},\\alpha_{2},...,\\alpha_{k}]$-$k$-partite hypertournament on $\\sum_{1}^{k}n_{i}$ vertices is a $(k+1)$-tuple $(U_{1},U_{2},...,U_{k},E)$, where $U_{i}$ are $k$ vertex sets with $|U_{i}|=n_{i}$, and $E$ is a set of $\\sum_{1}^{k}\\alpha_{i}$-tuples of vertices, called arcs, with exactly $\\alpha_{i}$ vertices from $U_{i}$, such that any $\\sum_{1}^{k}\\alpha_{i}$ subset $\\cup_{1}^{k}U_{i}^{\\prime}$ of $\\cup_{1}^{k}U_{i}$, $E$ contains exactly one of the $(\\sum_{1}^{k} \\alpha_{i})!$ $\\sum_{1}^{k}\\alpha_{i}$-tuples whose entries belong to $\\cup_{1}^{k}U_{i}^{\\prime}$. We obtain necessary and sufficient conditions for $k$ lists of non-negative integers in non-decreasing order to be the losing score lists and to be the score lists of some $k$-partite hypertournament.

  15. A locally adapted functional outcome measurement score for total ...

    African Journals Online (AJOL)

    ... of the Lequesne Index, used as Ouaga Score. It can be obtained easily and is reliable in a general West African patient population. We recommend the use of the Ouaga Score for functional evaluation and follow-up of THR in West Africa. Keywords: THR, Hip, Africa, Functional score, Hip replacement, Arthroscopy ...

  16. Maxillofacial trauma scoring systems.

    Science.gov (United States)

    Sahni, Vaibhav

    2016-07-01

    The changing complexity of maxillofacial fractures in recent years has created a situation where classical systems of classification of maxillofacial injuries fall short of defining trauma particularly that observed with high-velocity collisions where more than one region of the maxillofacial skeleton is affected. Trauma scoring systems designed specifically for the maxillofacial region are aimed to provide a more accurate assessment of the injury, its prognosis, the possible treatment outcomes, economics, length of hospital stay, and triage. The evolution and logic of such systems along with their merits and demerits are discussed. The author also proposes a new system to aid users in quickly and methodically choosing the system best suited to their needs without having to study a plethora of literature available in order to isolate their choice. Copyright © 2016 Elsevier Ltd. All rights reserved.

  17. Fingerprinting of music scores

    Science.gov (United States)

    Irons, Jonathan; Schmucker, Martin

    2004-06-01

    Publishers of sheet music are generally reluctant in distributing their content via the Internet. Although online sheet music distribution's advantages are numerous the potential risk of Intellectual Property Rights (IPR) infringement, e.g. illegal online distributions, disables any innovation propensity. While active protection techniques only deter external risk factors, additional technology is necessary to adequately treat further risk factors. For several media types including music scores watermarking technology has been developed, which ebeds information in data by suitable data modifications. Furthermore, fingerprinting or perceptual hasing methods have been developed and are being applied especially for audio. These methods allow the identification of content without prior modifications. In this article we motivate the development of watermarking and fingerprinting technologies for sheet music. Outgoing from potential limitations of watermarking methods we explain why fingerprinting methods are important for sheet music and address potential applications. Finally we introduce a condept for fingerprinting of sheet music.

  18. Relationship of Apgar Scores and Bayley Mental and Motor Scores

    Science.gov (United States)

    Serunian, Sally A.; Broman, Sarah H.

    1975-01-01

    Examined the relationship of newborns' 1-minute Apgar scores to their 8-month Bayley mental and motor scores and to 8-month classifications of their development as normal, suspect, or abnormal. Also investigated relationships between Apgar scores and race, longevity, and birth weight. (JMB)

  19. Credit Scoring Modeling

    Directory of Open Access Journals (Sweden)

    Siana Halim

    2014-01-01

    Full Text Available It is generally easier to predict defaults accurately if a large data set (including defaults is available for estimating the prediction model. This puts not only small banks, which tend to have smaller data sets, at disadvantage. It can also pose a problem for large banks that began to collect their own historical data only recently, or banks that recently introduced a new rating system. We used a Bayesian methodology that enables banks with small data sets to improve their default probability. Another advantage of the Bayesian method is that it provides a natural way for dealing with structural differences between a bank’s internal data and additional, external data. In practice, the true scoring function may differ across the data sets, the small internal data set may contain information that is missing in the larger external data set, or the variables in the two data sets are not exactly the same but related. Bayesian method can handle such kind of problem.

  20. Reliability of "Google" for obtaining medical information

    Directory of Open Access Journals (Sweden)

    Mihir Kothari

    2015-01-01

    Full Text Available Internet is used by many patients to obtain relevant medical information. We assessed the impact of "Google" search on the knowledge of the parents whose ward suffered from squint. In 21 consecutive patients, the "Google" search improved the mean score of the correct answers from 47% to 62%. We found that "Google" search was useful and reliable source of information for the patients with regards to the disease etiopathogenesis and the problems caused by the disease. The internet-based information, however, was incomplete and not reliable with regards to the disease treatment.

  1. Do Test Scores Buy Happiness?

    Science.gov (United States)

    McCluskey, Neal

    2017-01-01

    Since at least the enactment of No Child Left Behind in 2002, standardized test scores have served as the primary measures of public school effectiveness. Yet, such scores fail to measure the ultimate goal of education: maximizing happiness. This exploratory analysis assesses nation level associations between test scores and happiness, controlling…

  2. What Is the Apgar Score?

    Science.gov (United States)

    ... Shopping Healthy Drinks for Kids What Is the Apgar Score? KidsHealth > For Parents > What Is the Apgar ... Qué es la puntuación de Apgar? About the Apgar Score The Apgar score, the very first test ...

  3. Model for predicting the injury severity score.

    Science.gov (United States)

    Hagiwara, Shuichi; Oshima, Kiyohiro; Murata, Masato; Kaneko, Minoru; Aoki, Makoto; Kanbe, Masahiko; Nakamura, Takuro; Ohyama, Yoshio; Tamura, Jun'ichi

    2015-07-01

    To determine the formula that predicts the injury severity score from parameters that are obtained in the emergency department at arrival. We reviewed the medical records of trauma patients who were transferred to the emergency department of Gunma University Hospital between January 2010 and December 2010. The injury severity score, age, mean blood pressure, heart rate, Glasgow coma scale, hemoglobin, hematocrit, red blood cell count, platelet count, fibrinogen, international normalized ratio of prothrombin time, activated partial thromboplastin time, and fibrin degradation products, were examined in those patients on arrival. To determine the formula that predicts the injury severity score, multiple linear regression analysis was carried out. The injury severity score was set as the dependent variable, and the other parameters were set as candidate objective variables. IBM spss Statistics 20 was used for the statistical analysis. Statistical significance was set at P  Watson ratio was 2.200. A formula for predicting the injury severity score in trauma patients was developed with ordinary parameters such as fibrin degradation products and mean blood pressure. This formula is useful because we can predict the injury severity score easily in the emergency department.

  4. Predicting occupational personality test scores.

    Science.gov (United States)

    Furnham, A; Drakeley, R

    2000-01-01

    The relationship between students' actual test scores and their self-estimated scores on the Hogan Personality Inventory (HPI; R. Hogan & J. Hogan, 1992), an omnibus personality questionnaire, was examined. Despite being given descriptive statistics and explanations of each of the dimensions measured, the students tended to overestimate their scores; yet all correlations between actual and estimated scores were positive and significant. Correlations between self-estimates and actual test scores were highest for sociability, ambition, and adjustment (r = .62 to r = .67). The results are discussed in terms of employers' use and abuse of personality assessment for job recruitment.

  5. Prediction of true test scores from observed item scores and ancillary data.

    Science.gov (United States)

    Haberman, Shelby J; Yao, Lili; Sinharay, Sandip

    2015-05-01

    In many educational tests which involve constructed responses, a traditional test score is obtained by adding together item scores obtained through holistic scoring by trained human raters. For example, this practice was used until 2008 in the case of GRE(®) General Analytical Writing and until 2009 in the case of TOEFL(®) iBT Writing. With use of natural language processing, it is possible to obtain additional information concerning item responses from computer programs such as e-rater(®). In addition, available information relevant to examinee performance may include scores on related tests. We suggest application of standard results from classical test theory to the available data to obtain best linear predictors of true traditional test scores. In performing such analysis, we require estimation of variances and covariances of measurement errors, a task which can be quite difficult in the case of tests with limited numbers of items and with multiple measurements per item. As a consequence, a new estimation method is suggested based on samples of examinees who have taken an assessment more than once. Such samples are typically not random samples of the general population of examinees, so that we apply statistical adjustment methods to obtain the needed estimated variances and covariances of measurement errors. To examine practical implications of the suggested methods of analysis, applications are made to GRE General Analytical Writing and TOEFL iBT Writing. Results obtained indicate that substantial improvements are possible both in terms of reliability of scoring and in terms of assessment reliability. © 2015 The British Psychological Society.

  6. Method for obtaining Chromosomes Method for obtaining Chromosomes

    Directory of Open Access Journals (Sweden)

    Bogart James P.

    1973-09-01

    Full Text Available It is very easy to obtain chromosomes from anuran amphibians.Amphibians have very large chromosomes which can easily be seen with an ordinary microscope. The method used has been tested in the laboratory and also at collecting sites. All that is required are a few chemicals and simple equipment.It is very easy to obtain chromosomes from anuran amphibians.Amphibians have very large chromosomes which can easily be seen with an ordinary microscope. The method used has been tested in the laboratory and also at collecting sites. All that is required are a few chemicals and simple equipment.

  7. A generalizability study of the instrumental activities of daily living profile.

    Science.gov (United States)

    Bottari, Carolina; Dassa, Clément; Rainville, Constant; Dutil, Elisabeth

    2010-05-01

    To establish generalizability estimates of the Instrumental Activities of Daily Living (IADL) Profile when administered to persons with a moderate or severe traumatic brain injury (TBI) within their home and community environment. Generalizability theory was used to estimate generalizability and dependability coefficients as well as the relative contribution of identified sources of measurement error to total measurement error. Decision studies were used to enable the investigators to determine the optimal measurement design. The IADL Profile was administered in subjects' homes and community environments. Convenience sample of adults with a moderate or severe TBI (N=30, aged 16-65y). Not applicable. IADL Profile scores include 6 factor scores (going to the grocery store/shopping for groceries, having a meal with guests/cleaning up, putting on outdoor clothing, obtaining information, making a budget, and preparing a hot meal) and 1 total score. The greatest sources of measurement error were the subject-item interactions (3-random-facet design) and the subject-rater interactions (2-random-facet design). One hundred percent of generalizability coefficients of factor scores indicated acceptable to excellent reliability. Indices of dependability confirmed that 1 evaluator could reliably score the tool on a single occasion after having received a 3-day training workshop. The IADL Profile administered to persons with a moderate or severe TBI provides occupational therapists with a reliable set of measures of IADL independence capable of both capturing and analyzing the complex interactions between personal and environmental factors.

  8. [Propensity score matching in SPSS].

    Science.gov (United States)

    Huang, Fuqiang; DU, Chunlin; Sun, Menghui; Ning, Bing; Luo, Ying; An, Shengli

    2015-11-01

    To realize propensity score matching in PS Matching module of SPSS and interpret the analysis results. The R software and plug-in that could link with the corresponding versions of SPSS and propensity score matching package were installed. A PS matching module was added in the SPSS interface, and its use was demonstrated with test data. Score estimation and nearest neighbor matching was achieved with the PS matching module, and the results of qualitative and quantitative statistical description and evaluation were presented in the form of a graph matching. Propensity score matching can be accomplished conveniently using SPSS software.

  9. D-score: a search engine independent MD-score.

    Science.gov (United States)

    Vaudel, Marc; Breiter, Daniela; Beck, Florian; Rahnenführer, Jörg; Martens, Lennart; Zahedi, René P

    2013-03-01

    While peptides carrying PTMs are routinely identified in gel-free MS, the localization of the PTMs onto the peptide sequences remains challenging. Search engine scores of secondary peptide matches have been used in different approaches in order to infer the quality of site inference, by penalizing the localization whenever the search engine similarly scored two candidate peptides with different site assignments. In the present work, we show how the estimation of posterior error probabilities for peptide candidates allows the estimation of a PTM score called the D-score, for multiple search engine studies. We demonstrate the applicability of this score to three popular search engines: Mascot, OMSSA, and X!Tandem, and evaluate its performance using an already published high resolution data set of synthetic phosphopeptides. For those peptides with phosphorylation site inference uncertainty, the number of spectrum matches with correctly localized phosphorylation increased by up to 25.7% when compared to using Mascot alone, although the actual increase depended on the fragmentation method used. Since this method relies only on search engine scores, it can be readily applied to the scoring of the localization of virtually any modification at no additional experimental or in silico cost. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  10. Data Profiling

    OpenAIRE

    Hladíková, Radka

    2010-01-01

    Title: Data Profiling Author: Radka Hladíková Department: Department of Software Engineering Supervisor: Ing. Vladimír Kyjonka Supervisor's e-mail address: Abstract: This thesis puts mind on problems with data quality and data profiling. This Work analyses and summarizes problems of data quality, data defects, process of data quality, data quality assessment and data profiling. The main topic is data profiling as a process of researching data available in existing...

  11. Integrating Seasonal Oscillations into Basel II Behavioural Scoring Models

    Directory of Open Access Journals (Sweden)

    Goran Klepac

    2007-09-01

    Full Text Available The article introduces a new methodology of temporal influence measurement (seasonal oscillations, temporal patterns for behavioural scoring development purposes. The paper shows how significant temporal variables can be recognised and then integrated into the behavioural scoring models in order to improve model performance. Behavioural scoring models are integral parts of the Basel II standard on Internal Ratings-Based Approaches (IRB. The IRB approach much more precisely reflects individual risk bank profile.A solution of the problem of how to analyze and integrate macroeconomic and microeconomic factors represented in time series into behavioural scorecard models will be shown in the paper by using the REF II model.

  12. The Machine Scoring of Writing

    Science.gov (United States)

    McCurry, Doug

    2010-01-01

    This article provides an introduction to the kind of computer software that is used to score student writing in some high stakes testing programs, and that is being promoted as a teaching and learning tool to schools. It sketches the state of play with machines for the scoring of writing, and describes how these machines work and what they do.…

  13. Skyrocketing Scores: An Urban Legend

    Science.gov (United States)

    Krashen, Stephen

    2005-01-01

    A new urban legend claims, "As a result of the state dropping bilingual education, test scores in California skyrocketed." Krashen disputes this theory, pointing out that other factors offer more logical explanations of California's recent improvements in SAT-9 scores. He discusses research on the effects of California's Proposition 227,…

  14. Interpreting Linked Psychomotor Performance Scores

    Science.gov (United States)

    Looney, Marilyn A.

    2013-01-01

    Given that equating/linking applications are now appearing in kinesiology literature, this article provides an overview of the different types of linked test scores: equated, concordant, and predicted. It also addresses the different types of evidence required to determine whether the scores from two different field tests (measuring the same…

  15. Trends in Classroom Observation Scores

    Science.gov (United States)

    Casabianca, Jodi M.; Lockwood, J. R.; McCaffrey, Daniel F.

    2015-01-01

    Observations and ratings of classroom teaching and interactions collected over time are susceptible to trends in both the quality of instruction and rater behavior. These trends have potential implications for inferences about teaching and for study design. We use scores on the Classroom Assessment Scoring System-Secondary (CLASS-S) protocol from…

  16. Matching score based face recognition

    NARCIS (Netherlands)

    Boom, B.J.; Beumer, G.M.; Spreeuwers, Lieuwe Jan; Veldhuis, Raymond N.J.

    2006-01-01

    Accurate face registration is of vital importance to the performance of a face recognition algorithm. We propose a new method: matching score based face registration, which searches for optimal alignment by maximizing the matching score output of a classifier as a function of the different

  17. Quadratic prediction of factor scores

    NARCIS (Netherlands)

    Wansbeek, T

    1999-01-01

    Factor scores are naturally predicted by means of their conditional expectation given the indicators y. Under normality this expectation is linear in y but in general it is an unknown function of y. II is discussed that under nonnormality factor scores can be more precisely predicted by a quadratic

  18. SHORT COMMUNICATION INTERMEDIATE OBTAINED FROM ...

    African Journals Online (AJOL)

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    selectivity is the ratio of the rate constant of the reaction of carbocation with an externally added nucleophile, (nu, aniline) to that of the rate constant of the water. Our intention was to obtain a carbocation with high selectivity, so that one can pave a path for the synthesis of Schiff's base by the reaction of the carbocation ...

  19. Reliability of Scores on the Summative Performance Assessments

    Science.gov (United States)

    Yang, Yanyun; Oosterhof, Albert; Xia, Yan

    2015-01-01

    The authors address the reliability of scores obtained on the summative performance assessments during the pilot year of our research. Contrary to classical test theory, we discussed the advantages of using generalizability theory for estimating reliability of scores for summative performance assessments. Generalizability theory was used as the…

  20. The Reliability of Difference Scores in Populations and Samples

    Science.gov (United States)

    Zimmerman, Donald W.

    2009-01-01

    This study was an investigation of the relation between the reliability of difference scores, considered as a parameter characterizing a population of examinees, and the reliability estimates obtained from random samples from the population. The parameters in familiar equations for the reliability of difference scores were redefined in such a way…

  1. The power and robustness of maximum LOD score statistics.

    Science.gov (United States)

    Yoo, Y J; Mendell, N R

    2008-07-01

    The maximum LOD score statistic is extremely powerful for gene mapping when calculated using the correct genetic parameter value. When the mode of genetic transmission is unknown, the maximum of the LOD scores obtained using several genetic parameter values is reported. This latter statistic requires higher critical value than the maximum LOD score statistic calculated from a single genetic parameter value. In this paper, we compare the power of maximum LOD scores based on three fixed sets of genetic parameter values with the power of the LOD score obtained after maximizing over the entire range of genetic parameter values. We simulate family data under nine generating models. For generating models with non-zero phenocopy rates, LOD scores maximized over the entire range of genetic parameters yielded greater power than maximum LOD scores for fixed sets of parameter values with zero phenocopy rates. No maximum LOD score was consistently more powerful than the others for generating models with a zero phenocopy rate. The power loss of the LOD score maximized over the entire range of genetic parameters, relative to the maximum LOD score calculated using the correct genetic parameter value, appeared to be robust to the generating models.

  2. Extension of the lod score: the mod score.

    Science.gov (United States)

    Clerget-Darpoux, F

    2001-01-01

    In 1955 Morton proposed the lod score method both for testing linkage between loci and for estimating the recombination fraction between them. If a disease is controlled by a gene at one of these loci, the lod score computation requires the prior specification of an underlying model that assigns the probabilities of genotypes from the observed phenotypes. To address the case of linkage studies for diseases with unknown mode of inheritance, we suggested (Clerget-Darpoux et al., 1986) extending the lod score function to a so-called mod score function. In this function, the variables are both the recombination fraction and the disease model parameters. Maximizing the mod score function over all these parameters amounts to maximizing the probability of marker data conditional on the disease status. Under the absence of linkage, the mod score conforms to a chi-square distribution, with extra degrees of freedom in comparison to the lod score function (MacLean et al., 1993). The mod score is asymptotically maximum for the true disease model (Clerget-Darpoux and Bonaïti-Pellié, 1992; Hodge and Elston, 1994). Consequently, the power to detect linkage through mod score will be highest when the space of models where the maximization is performed includes the true model. On the other hand, one must avoid overparametrization of the model space. For example, when the approach is applied to affected sibpairs, only two constrained disease model parameters should be used (Knapp et al., 1994) for the mod score maximization. It is also important to emphasize the existence of a strong correlation between the disease gene location and the disease model. Consequently, there is poor resolution of the location of the susceptibility locus when the disease model at this locus is unknown. Of course, this is true regardless of the statistics used. The mod score may also be applied in a candidate gene strategy to model the potential effect of this gene in the disease. Since, however, it

  3. Evaluation and analysis of term scoring methods for term extraction

    NARCIS (Netherlands)

    Verberne, S.; Sappelli, M.; Hiemstra, D.; Kraaij, W.

    2016-01-01

    We evaluate five term scoring methods for automatic term extraction on four different types of text collections: personal document collections, news articles, scientific articles and medical discharge summaries. Each collection has its own use case: author profiling, boolean query term suggestion,

  4. Scoring clinical competencies of learners: A quantitative descriptive ...

    African Journals Online (AJOL)

    This study sought to determine possible reason(s) for this observation. The objectives were to explore and describe the demographic profile of learners and the correlation between different clinical assessors' scoring of learners. A purposive convenience sample consisted of learners (n = 34) and clinical assessors (n = 6).

  5. The quality of obtaining surgical informed consent.

    Science.gov (United States)

    Joolaee, Soodabeh; Faghanipour, Somayeh; Hajibabaee, Fatemeh

    2017-03-01

    Informed consent goes beyond signing a form; it is a process of providing necessary information, helping patients make an informed decision, and actively participate in their treatment. This study aimed to assess the quality of obtaining surgical informed consent in hospitals affiliated with Tehran University of Medical Sciences. Research design/participants/context: In a cross-sectional, descriptive-analytical study, 300 patients were chosen through stratified sampling from seven hospitals affiliated with Tehran University of Medical Sciences. Data were collected using a questionnaire developed by the researchers and analyzed using descriptive and analytical statistics on SPSS software. Ethical considerations: Ethical approval of this study was granted by Tehran University of Medical Sciences research ethics committee. Written informed consent for participation was obtained. The participants were reassured that their information will be used anonymously and their answers will not affect their treatment and care. The mean score of quality of acquisition of informed consent was 17.13 out of 35, indicating that the quality falls in the inappropriate category. The results indicate that 48% of the signatories do not even read the form before signing it. Among the 52% who did read the consent form, 61.3% mentioned varying degrees of incomprehensibility of the consent form and 94.2% mentioned the presence of incomprehensible technical, medical and legal vocabulary. Only 12% and 18% of respondents reported that they were not in hurry and they had no fear or anxiety, respectively, when signing the form. The quality of obtaining informed consent was higher in women, younger patients, patients with higher education, and those who had special surgeries. This study shows a poor practice in obtaining surgical informed consent in Iran. It seems necessary to consider fundamental changes in the process of acquiring consent based on the temporal and local conditions of the patients.

  6. Improving personality facet scores with multidimensional computer adaptive testing

    DEFF Research Database (Denmark)

    Makransky, Guido; Mortensen, Erik Lykke; Glas, Cees A W

    2013-01-01

    personality tests contain many highly correlated facets. This article investigates the possibility of increasing the precision of the NEO PI-R facet scores by scoring items with multidimensional item response theory and by efficiently administering and scoring items with multidimensional computer adaptive...... testing (MCAT). The increase in the precision of personality facet scores is obtained from exploiting the correlations between the facets. Results indicate that the NEO PI-R could be substantially shorter without attenuating precision when the MCAT methodology is used. Furthermore, the study shows...

  7. Building a Scoring Model for Small and Medium Enterprises

    Directory of Open Access Journals (Sweden)

    Răzvan Constantin CARACOTA

    2010-09-01

    Full Text Available The purpose of the paper is to produce a scoring model for small and medium enterprises seeking financing through a bank loan. To analyze the loan application, scoring system developed for companies is as follows: scoring quantitative factors and scoring qualitative factors. We have estimated the probability of default using logistic regression. Regression coefficients determination was made with a solver in Excel using five ratios as input data. Analyses and simulations were conducted on a sample of 113 companies, all accepted for funding. Based on financial information obtained over two years, 2007 and 2008, we could establishe and appreciate the default value.

  8. Inpatient nursing care and early warning scores: a workflow mismatch.

    Science.gov (United States)

    Watson, Anne; Skipper, Chantel; Steury, Rachel; Walsh, Heather; Levin, Amanda

    2014-01-01

    Early warning scores calculated by registered nurses (RNs) are used in hospitals to enhance the recognition of and communication about patient deterioration. This study evaluated workflow variables surrounding calculation and documentation of one pediatric hospital's use of an early warning score. Results indicated that there were significant delays in documentation of early warning scores by RNs and inconsistencies between the early warning scores and vital signs collected and documented by non-RN personnel. These findings reflected information obtained from the RNs about how they prioritize tasks and use work-arounds to specific systems issues regarding assessment and documentation in the electronic medical record.

  9. State Test Score Trends through 2008-09, Part 1: Rising Scores on State Tests and NAEP. Texas

    Science.gov (United States)

    Center on Education Policy, 2010

    2010-01-01

    This paper profiles Texas' test score trends through 2008-09. Between 2005 and 2009, the percentages of students reaching the proficient level on the state test and the basic level on NAEP (National Assessment of Educational Progress) increased in reading at grades 4 and 8 and in math at grade 8. In grade 4 math, however, the percentage scoring…

  10. Using conjoint analysis to develop a system to score research engagement actions by health decision makers.

    Science.gov (United States)

    Makkar, Steve R; Williamson, Anna; Turner, Tari; Redman, Sally; Louviere, Jordan

    2015-04-26

    Effective use of research to inform policymaking can be strengthened by policymakers undertaking various research engagement actions (e.g., accessing, appraising, and applying research). Consequently, we developed a thorough measurement and scoring tool to assess whether and how policymakers undertook research engagement actions in the development of a policy document. This scoring tool breaks down each research engagement action into its key 'subactions' like a checklist. The primary aim was to develop the scoring tool further so that it assigned appropriate scores to each subaction based on its effectiveness for achieving evidence-informed policymaking. To establish the relative effectiveness of these subactions, we conducted a conjoint analysis, which was used to elicit the opinions and preferences of knowledge translation experts. Fifty-four knowledge translation experts were recruited to undertake six choice surveys. Respondents were exposed to combinations of research engagement subactions called 'profiles', and rated on a 1-9 scale whether each profile represented a limited (1-3), moderate (4-6), or extensive (7-9) example of each research engagement action. Generalised estimating equations were used to analyse respondents' choice data, where a utility coefficient was calculated for each subaction. A large utility coefficient indicates that a subaction was influential in guiding experts' ratings of extensive engagement with research. The calculated utilities were used as the points assigned to the subactions in the scoring system. The following subactions yielded the largest utilities and were regarded as the most important components of engaging with research: searching academic literature databases, obtaining systematic reviews and peer-reviewed research, appraising relevance by verifying its applicability to the policy context, appraising quality by evaluating the validity of the method and conclusions, engaging in thorough collaborations with researchers

  11. New reliable scoring system, Toyama mouse score, to evaluate locomotor function following spinal cord injury in mice.

    Science.gov (United States)

    Shigyo, Michiko; Tanabe, Norio; Kuboyama, Tomoharu; Choi, Song-Hyen; Tohda, Chihiro

    2014-06-03

    Among the variety of methods used to evaluate locomotor function following a spinal cord injury (SCI), the Basso Mouse Scale score (BMS) has been widely used for mice. However, the BMS mainly focuses on hindlimb movement rather than on graded changes in body support ability. In addition, some of the scoring methods include double or triple criteria within a single score, which likely leads to an increase in the deviation within the data. Therefore we aimed to establish a new scoring method reliable and easy to perform in mice with SCI. Our Toyama Mouse Score (TMS) was established by rearranging and simplifying the BMS score and combining it with the Body Support Scale score (BSS). The TMS reflects changes in both body support ability and hindlimb movement. The definition of single score is made by combing multiple criteria in the BMS. The ambiguity was improved in the TMS. Using contusive SCI mice, hindlimb function was measured using the TMS, BMS and BSS systems. The TMS could distinguish changes in hindlimb movements that were evaluated as the same score by the BMS. An analysis of the coefficient of variation (CV) of score points recorded for 11 days revealed that the CV for the TMS was significantly lower than the CV obtained using the BMS. A variation in intra evaluators was lower in the TMS than in the BMS. These results suggest that the TMS may be useful as a new reliable method for scoring locomotor function for SCI models.

  12. Nasalance scores for normal-speaking Turkish population.

    Science.gov (United States)

    Karakoc, Omer; Akcam, Timur; Birkent, Hakan; Arslan, Hasan Huseyin; Gerek, Mustafa

    2013-03-01

    The aim of this study was to obtain normative nasalance scores for adult and children subjects speaking Turkish language and obtain a reference for normality when nasality is evaluated. Mean nasalance scores were obtained from 35 normal-speaking children aged 7 to 13 years, and 125 adults aged 18 to 69 years during the repetition of 3 nasalance passages that were categorized according to the amount of nasal consonants (oral, oronasal, and nasal passages). The Nasometer (model 6400) was used to obtain nasalance scores for the 3 reading passages. Group mean ± SD nasalance scores of children for oral passage, oronasal passage, and nasal passage were 15.14 ± 4.81, 37.76 ± 4.42, and 49.23 ± 6.95, respectively. Nasalance scores for the adult group were 13.46 ± 6.26, 37.84 ± 6.13, and 50.28 ± 7.77, respectively. There were significant differences in mean nasalance scores for oral versus nasal materials both for children and adult groups. The present study provides normative nasalance scores for Turkish-speaking children and adults. The results indicated acceptable differentiation between oral and nasal materials.

  13. Psychosocial Profiles of Temporomandibular Disorder Pain Patients

    DEFF Research Database (Denmark)

    Kothari, Simple Futarmal; Baad-Hansen, Lene; Svensson, Peter

    2017-01-01

    AIMS: To propose a visual method to screen and assess psychosocial functioning in temporomandibular disorder (TMD) pain patients in comparison with age- and gender-matched healthy controls by forming individual profiles and to evaluate the association between psychosocial profiles and quantitative...... scores were analyzed with t tests. T scores of psychosocial parameters and z scores of QST parameters were correlated using Spearman's correlation (ρ). RESULTS: Most (96.6%) TMD pain patients exhibited one or more parameters indicative of psychosocial distress, with psychological disability scores being...

  14. Profiles of Everyday Thought Suppression

    OpenAIRE

    Ie, Amanda Yen Lin

    2014-01-01

    The present research assessed whether levels of depression, anxiety and worry, obsessive-compulsive distress, and psychopathy were differentially related to distinct thought suppression profiles. As a means to achieving this goal, the Profiles of Everyday Thought Suppression (PETS) scale was constructed to measure the frequencies with which various target thoughts are suppressed. The PETS scale demonstrated good internal consistency and test-retest reliability, and scores were positively co...

  15. Scoring the SF-36 in Orthopaedics: A Brief Guide.

    Science.gov (United States)

    Laucis, Nicholas C; Hays, Ron D; Bhattacharyya, Timothy

    2015-10-07

    The Short Form-36 (SF-36) is the most widely used health-related quality-of-life measure in research to date. There are currently two sources for the SF-36 and scoring instructions: licensing them from Optum, Inc., or obtaining them from publicly available documentation from the RAND Corporation. The SF-36 yields eight scale scores and two summary scores. The physical component summary (PCS) and mental component summary (MCS) scores were derived using an orthogonal-factor analytic model that forced the PCS and MCS to be uncorrelated, and it has been shown to contribute to an inflation of the MCS in patients with substantial physical disability. Oblique scoring can reduce this inflation of the MCS in orthopaedic studies. Spreadsheets to score the SF-36, along with a copy of the questionnaire, are provided. Copyright © 2015 by The Journal of Bone and Joint Surgery, Incorporated.

  16. Optical Music Recognition for Scores Written in White Mensural Notation

    Directory of Open Access Journals (Sweden)

    Antonio Oliver

    2009-01-01

    Full Text Available An Optical Music Recognition (OMR system especially adapted for handwritten musical scores of the XVII-th and the early XVIII-th centuries written in white mensural notation is presented. The system performs a complete sequence of analysis stages: the input is the RGB image of the score to be analyzed and, after a preprocessing that returns a black and white image with corrected rotation, the staves are processed to return a score without staff lines; then, a music symbol processing stage isolates the music symbols contained in the score and, finally, the classification process starts to obtain the transcription in a suitable electronic format so that it can be stored or played. This work will help to preserve our cultural heritage keeping the musical information of the scores in a digital format that also gives the possibility to perform and distribute the original music contained in those scores.

  17. DIFFERENCES IN RESULTS OBTAINED BY STUDENTS OF DIFFERENT FACULTIES

    Directory of Open Access Journals (Sweden)

    OTAVOVÁ, Miroslava

    2016-03-01

    Full Text Available The paper presents and discusses the results of statistical analysis of differences among scores obtained by students of different faculties of the University of Economics in Prague. The analysed dataset contains the scores for 2256 students that took basic mathematics course during the academic year 2013/2014. A two way analysis of variance was performed with semester and faculty as main factors. The interaction between these two factors was also considered. Students have to take two tests. At first, the sum of the scores obtained from both tests is analysed and then, the two tests are analysed separately. It turns out that the significance of factors is the same in the three analyses. The assumptions of linear models are verified. Due to problem of heteroscedasticity, weighted least squares are used and the possibility of using Box-Cox transformation is also discussed, as the errors are not normally distributed. Finally, the differences between the faculties are described.

  18. Alimentary Habits, Physical Activity, and Framingham Global Risk Score in Metabolic Syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Soares, Thays Soliman; Piovesan, Carla Haas; Gustavo, Andréia da Silva; Macagnan, Fabrício Edler; Bodanese, Luiz Carlos; Feoli, Ana Maria Pandolfo, E-mail: anamariafeoli@hotmail.com [Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, RS (Brazil)

    2014-04-15

    Metabolic syndrome is a complex disorder represented by a set of cardiovascular risk factors. A healthy lifestyle is strongly related to improve Quality of Life and interfere positively in the control of risk factors presented in this condition. To evaluate the effect of a program of lifestyle modification on the Framingham General Cardiovascular Risk Profile in subjects diagnosed with metabolic syndrome. A sub-analysis study of a randomized clinical trial controlled blind that lasted three months. Participants were randomized into four groups: dietary intervention + placebo (DIP), dietary intervention + supplementation of omega 3 (fish oil 3 g/day) (DIS3), dietary intervention + placebo + physical activity (DIPE) and dietary intervention + physical activity + supplementation of omega 3 (DIS3PE). The general cardiovascular risk profile of each individual was calculated before and after the intervention. The study included 70 subjects. Evaluating the score between the pre and post intervention yielded a significant value (p < 0.001). We obtained a reduction for intermediate risk in 25.7% of subjects. After intervention, there was a significant reduction (p < 0.01) on cardiovascular age, this being more significant in groups DIP (5.2%) and DIPE (5.3%). Proposed interventions produced beneficial effects for reducing cardiovascular risk score. This study emphasizes the importance of lifestyle modification in the prevention and treatment of cardiovascular diseases.

  19. Alimentary habits, physical activity, and Framingham global risk score in metabolic syndrome.

    Science.gov (United States)

    Soares, Thays Soliman; Piovesan, Carla Haas; Gustavo, Andréia da Silva; Macagnan, Fabrício Edler; Bodanese, Luiz Carlos; Feoli, Ana Maria Pandolfo

    2014-04-01

    Metabolic syndrome is a complex disorder represented by a set of cardiovascular risk factors. A healthy lifestyle is strongly related to improve Quality of Life and interfere positively in the control of risk factors presented in this condition. To evaluate the effect of a program of lifestyle modification on the Framingham General Cardiovascular Risk Profile in subjects diagnosed with metabolic syndrome. A sub-analysis study of a randomized clinical trial controlled blind that lasted three months. Participants were randomized into four groups: dietary intervention + placebo (DIP), dietary intervention + supplementation of omega 3 (fish oil 3 g/day) (DIS3), dietary intervention + placebo + physical activity (DIPE) and dietary intervention + physical activity + supplementation of omega 3 (DIS3PE). The general cardiovascular risk profile of each individual was calculated before and after the intervention. The study included 70 subjects. Evaluating the score between the pre and post intervention yielded a significant value (p < 0.001). We obtained a reduction for intermediate risk in 25.7% of subjects. After intervention, there was a significant reduction (p < 0.01) on cardiovascular age, this being more significant in groups DIP (5.2%) and DIPE (5.3%). Proposed interventions produced beneficial effects for reducing cardiovascular risk score. This study emphasizes the importance of lifestyle modification in the prevention and treatment of cardiovascular diseases.

  20. Program analysis and presentation of results of the profiles and depth dose rates obtained with the PTW software MC{sub 2} MEPHYSTO; Programa de analisis y presentacion de resultados de los perfiles y porcentajes de dosis en profundidad adquiridos con el software MEPHYSTO MC2 de PTW

    Energy Technology Data Exchange (ETDEWEB)

    Tato de la Cuevas, F.

    2011-07-01

    In the periodic quality control of linear accelerators is usually included acquisition and analysis of profiles and PDDs (percentage depth dose). In the protocol of Quality Control of electron accelerators for clinical use of the proposed analysis SEFM 4 Profiles for each of the energies used clinically. This involves a large number of curves to be analyzed and the subsequent introduction of the parameters in a spreadsheet or similar for your assessment as to the reference state. We have developed a program that analyzes the curves acquired by mcc Mephysto PTW software and presents the results of that analysis in a spreadsheet.

  1. Drugs obtained by biotechnology processing

    Directory of Open Access Journals (Sweden)

    Hugo Almeida

    2011-06-01

    Full Text Available In recent years, the number of drugs of biotechnological origin available for many different diseases has increased exponentially, including different types of cancer, diabetes mellitus, infectious diseases (e.g. AIDS Virus / HIV as well as cardiovascular, neurological, respiratory, and autoimmune diseases, among others. The pharmaceutical industry has used different technologies to obtain new and promising active ingredients, as exemplified by the fermentation technique, recombinant DNA technique and the hybridoma technique. The expiry of the patents of the first drugs of biotechnological origin and the consequent emergence of biosimilar products, have posed various questions to health authorities worldwide regarding the definition, framework, and requirements for authorization to market such products.Nos últimos anos, tem aumentado exponencialmente o número de fármacos de origem biotecnológica ao dispor das mais diversas patologias, entre elas destacam-se, os diferentes tipos de cancêr, as doenças infecciosas (ex. vírus AIDS/HIV, as doenças autoimunes, as doenças cardiovasculares, a Diabetes Mellitus, as doenças neurológicas, as doenças respiratórias, entre outras. A indústria farmacêutica tem recorrido a diferentes tecnologias para a obtenção de novos e promissores princípios ativos, como são exemplo a fermentação, a técnica de DNA Recombinante, a técnica de hidridoma, entre outras. A queda das patentes dos primeiros fármacos de origem biotecnológica e o consequente aparecimento dos produtos biossimilares têm colocado diferentes questões às autoridades de saúde mundiais, sobre a definição, enquadramento e exigências para a autorização de entrada no mercado deste tipo de produtos.

  2. Skin scoring in systemic sclerosis

    DEFF Research Database (Denmark)

    Zachariae, Hugh; Bjerring, Peter; Halkier-Sørensen, Lars

    1994-01-01

    Forty-one patients with systemic sclerosis were investigated with a new and simple skin score method measuring the degree of thickening and pliability in seven regions together with area involvement in each region. The highest values were, as expected, found in diffuse cutaneous systemic sclerosis...... (type III SS) and the lowest in limited cutaneous systemic sclerosis (type I SS) with no lesions extending above wrists and ancles. A positive correlation was found to the aminoterminal propeptide of type III procollagen, a serological marker for synthesis of type III collagen. The skin score...

  3. From Rasch scores to regression

    DEFF Research Database (Denmark)

    Christensen, Karl Bang

    2006-01-01

    Rasch models provide a framework for measurement and modelling latent variables. Having measured a latent variable in a population a comparison of groups will often be of interest. For this purpose the use of observed raw scores will often be inadequate because these lack interval scale propertie...

  4. Developing Scoring Algorithms (Earlier Methods)

    Science.gov (United States)

    We developed scoring procedures to convert screener responses to estimates of individual dietary intake for fruits and vegetables, dairy, added sugars, whole grains, fiber, and calcium using the What We Eat in America 24-hour dietary recall data from the 2003-2006 NHANES.

  5. The persistence of depression score

    NARCIS (Netherlands)

    Spijker, J.; de Graaf, R.; Ormel, J.; Nolen, W. A.; Grobbee, D. E.; Burger, H.

    2006-01-01

    Objective: To construct a score that allows prediction of major depressive episode (MDE) persistence in individuals with MDE using determinants of persistence identified in previous research. Method: Data were derived from 250 subjects from the general population with new MDE according to DSM-III-R.

  6. The HiSCORE Project

    Directory of Open Access Journals (Sweden)

    M. Tluczykont

    2014-12-01

    Full Text Available A central question of Astroparticle Physics, the origin of cosmic rays, still remains unsolved. HiSCORE (Hundred*i Square-km Cosmic ORigin Explorer is a concept for a large-area wide-angle non-imaging air shower detector, addressing this question by searching for cosmic ray pevatrons in the energy range from 10TeV to few PeV and cosmic rays in the energy range above 100TeV. In the framework of the Tunka-HiSCORE project, first prototypes have been deployed on the site of the Tunka-133 experiment, where we plan to install an engineering array covering an area of the order of 1km2. On the same site, also imaging and particle detectors are planned, potentially allowing a future hybrid detector system. Here we present the HiSCORE detector principle, its potential for cosmic ray origin search and the status of ongoing activities in the framework of the Tunka-HiSCORE experiment.

  7. Nasalance scores for normal-speaking Irish children.

    Science.gov (United States)

    Sweeney, Triona; Sell, Debbie; O'Regan, Myra

    2004-03-01

    To obtain normal nasalance values during the production of a standardized speech sample for Irish children and determine whether significantly different scores exist for different speech stimuli for female and male speakers. Mean nasalance scores were obtained for normal-speaking children during the repetition of 16 test sentences that were categorized according to consonant type within the sentences (high-pressure consonants, low-pressure consonants, nasal consonants). Seventy children (36 girls and 34 boys, aged 4 years 11 months to 13 years) with normal articulation, resonance, and voice were included. Children repeated each of the 16 test sentences individually. The sentences were presented in groups according to consonant type, referred to as sentence categories. Data were collected and analyzed using the Kay nasometer (model 6200.3). Nasalance scores were obtained for the total speech sample and each sentence category. Data were statistically analyzed to investigate the effects of gender, sentence category, and gender by sentence category. Normative nasalance scores were obtained for the total speech sample (26%), high-pressure consonant sentences (14%), low-pressure consonant sentences (16%), and a nasal consonant sentence (51%). There was no significant difference in nasalance scores between male and female speakers. Significant differences were found between each sentence category (p scores for different speech stimuli.

  8. A MATLAB tool for pathway enrichment using a topology-based pathway regulation score.

    Science.gov (United States)

    Ibrahim, Maysson; Jassim, Sabah; Cawthorne, Michael Anthony; Langlands, Kenneth

    2014-11-04

    Handling the vast amount of gene expression data generated by genome-wide transcriptional profiling techniques is a challenging task, demanding an informed combination of pre-processing, filtering and analysis methods if meaningful biological conclusions are to be drawn. For example, a range of traditional statistical and computational pathway analysis approaches have been used to identify over-represented processes in microarray data derived from various disease states. However, most of these approaches tend not to exploit the full spectrum of gene expression data, or the various relationships and dependencies. Previously, we described a pathway enrichment analysis tool created in MATLAB that yields a Pathway Regulation Score (PRS) by considering signalling pathway topology, and the overrepresentation and magnitude of differentially-expressed genes (J Comput Biol 19:563-573, 2012). Herein, we extended this approach to include metabolic pathways, and described the use of a graphical user interface (GUI). Using input from a variety of microarray platforms and species, users are able to calculate PRS scores, along with a corresponding z-score for comparison. Further pathway significance assessment may be performed to increase confidence in the pathways obtained, and users can view Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway diagrams marked-up to highlight impacted genes. The PRS tool provides a filter in the isolation of biologically-relevant insights from complex transcriptomic data.

  9. Re-Scoring the Game’s Score

    DEFF Research Database (Denmark)

    Gasselseder, Hans-Peter

    2014-01-01

    -temporal alignment in the resulting emotional congruency of nondiegetic music. Whereas imaginary aspects of immersive presence are systemically affected by the presentation of dynamic music, sensory spatial aspects show higher sensitivity towards the arousal potential of the music score. It is argued......This study explores immersive presence as well as emotional valence and arousal in the context of dynamic and non-dynamic music scores in the 3rd person action-adventure video game genre while also considering relevant personality traits of the player. 60 subjects answered self......-report questionnaires of experiential states each time after playing the game 'Batman: Arkham City' in one of three randomized conditions accounting for [1] dynamic music, [2] non-dynamic music/low arousal potential and [3] non-dynamic music/high arousal potential, aiming to manipulate emotional arousal and structural...

  10. Automated Detection of Binucleated Cell and Micronuclei using CellProfiler 2.0 Software

    Directory of Open Access Journals (Sweden)

    Dwi Ramadhani

    2013-12-01

    Full Text Available Micronucleus assay in human peripheral lymphocytes usually used to assess chromosomal damage. Manual scoring of micronuclei can be time consuming and large numbers of binucleated cells have to be analyzed to obtain statistically relevant data. Automation of the micronuclei analysis using image processing analysis software can provide a faster and more reliable analysis of micronucleus assay. Here the used of CellProfiler an open access cell image analysis software for automatic detection of binucleated cells and micronuclei were reported. We aimed to know whether there was a significant difference in the number of binucleated cells and micronuclei that obtained by manual and CellProfiler counting. Wilcoxon Rank test was used for statistical analysis to test H0 hypothesis that there was no significant difference in the number of binucleated cells and micronuclei that obtained by manual and CellProfiler counting. We analyzed 135 images for both manual and CellProfiler counting. Our results showed that there was no significant difference between manual and CellProfiler counting for binucleated cells (P = 0.851 and for micronuclei (P = 0.917. In conclusion, the binucleated cells and micronuclei counting using CellProfiler were comparable but not better than manual counting.

  11. Professionalism score and academic performance in osteopathic medical students.

    Science.gov (United States)

    Snider, Karen T; Johnson, Jane C

    2014-11-01

    During the first 2 years of osteopathic medical school, osteopathic manipulative medicine (OMM) courses use an objective professionalism score to measure student timeliness and appropriate dress for learning activities. To assess for correlations between this score and the numeric course grades of all first- and second-year basic science and clinical courses at a single osteopathic medical school. The professionalism scores obtained for each of the 7 quarters of the OMM course (2007-2012) were compared with the students' numeric final course grades and combined grade point average (GPA) of all courses in the corresponding quarter. Spearman correlation coefficients were used to determine the strength of the relationship between the professionalism score and the final course grades and the combined GPA. The mean (SD) professionalism score was 98.6% (3.3%), and scores ranged from 23.1% to 100%. Excluding the OMM course, the professionalism score was positively correlated with 29% of first-year course grades and 65% of second-year course grades. The professionalism score was predictive of academic performance in 16 of 23 clinical courses with the highest correlation for Principles of Medicine and Dermatology (ρ=0.28 and ρ=0.25, respectively). The OMM professionalism score was positively associated with GPA for quarters 1, 6, and 7 (P=.006, Posteopathic medical school courses, particularly clinical courses in the second-year curriculum. © 2014 The American Osteopathic Association.

  12. Biophysical Profile

    Science.gov (United States)

    ... and pregnancy High-risk pregnancy Biophysical profile About Advertisement Mayo Clinic does not endorse companies or products. ... a Job Site Map About This Site Twitter Facebook Google YouTube Pinterest Mayo Clinic is a not- ...

  13. Arteriovenous malformation embocure score: AVMES.

    Science.gov (United States)

    Lopes, Demetrius K; Moftakhar, Roham; Straus, David; Munich, Stephan A; Chaus, Fahad; Kaszuba, Megan C

    2016-07-01

    Cerebral arteriovenous malformations (CAVMs) may be treated with microsurgery, radiosurgery, endovascular surgery, or a combination of these modalities. Grading scales are available to aid the assessment of curative risk for microsurgery and radiosurgery. No grading system has been developed to assess the curative risk of endovascular surgery. To report our retrospective application of the AVM embocure score to patients treated at our institution between 2005 and 2011 METHODS: We performed a retrospective review of 39 patients with CAVM treated at our institution between 2005 and 2011 with the primary aim of achieving a curative embolization. After reviewing all the different variables associated with the conventional Onyx embolization technique for CAVMs, we identified the following as the most relevant characteristics influencing the chances for complete angiographic embolization and complication risk: the number of arterial pedicles and draining veins, size of AVM nidus, and vascular eloquence. We sought to develop a scoring system to assess the complication risk for a curative embolization of CAVM with liquid embolic Onyx (Covidien, Irvine, California, USA). We developed the AVM embocure score (AVMES). This scoring system ranges from 3 to 10 and is the arithmetic sum of the number of arterial pedicles feeding the AVM (≤3, 4-6, >6), the number of draining veins (≤3, 4-6, >6), the size of the AVM nidus in centimeters (≤3, 4-6, >6), and the vascular eloquence (0-1). We applied AVMES to the same cohort of patients and validated the predictability of complete angiographic embolization and expected clinical risk of complication. In lesions with an AVMES of 3 (n=8), there was a 100% rate of complete AVM obliteration and 0% rate of major complications. In AVMES 4 (n=12) lesions, there was 75% complete obliteration rate, with 8% major morbidity. In AVMES 5 (n=9) lesions, there was 78% complete obliteration and 11% major morbidity. In AVMES >5 (n=10) there was 20

  14. Profiling cancer

    DEFF Research Database (Denmark)

    Ciro, Marco; Bracken, Adrian P; Helin, Kristian

    2003-01-01

    In the past couple of years, several very exciting studies have demonstrated the enormous power of gene-expression profiling for cancer classification and prediction of patient survival. In addition to promising a more accurate classification of cancer and therefore better treatment of patients......, gene-expression profiling can result in the identification of novel potential targets for cancer therapy and a better understanding of the molecular mechanisms leading to cancer....

  15. Conversion “V” Profiles in Torticollis

    Directory of Open Access Journals (Sweden)

    M. Jahanshahi

    1989-01-01

    Full Text Available The assumption that spasmodic torticollis represents a conversion reaction was examined by evaluating profiles of 61 patients on the hypochondriasis, depression, and hysteria scales of the Minnesota Multiphasic Personality Inventory. Thirty-six per cent of the sample had normal profiles. A conversion “V” profile with scores above 70 was found in a minority (9% of the patients. The profile of the majority of the group was characterized by the presence of mild depression. It was concluded that a personality profile suggestive of conversion reaction is not typical of patients with spasmodic torticollis.

  16. Congruence of Strong and Kuder Interest Profiles

    Science.gov (United States)

    Johnson, Richard W.

    1971-01-01

    Scores on scales with identical or similar names on the Strong Vocational Interest Blank for Women and the Kuder Occupational Interest Survey were compared by means of both scale and profile analyses. The individual scales were only moderately intercorrelated; however, the total profiles revealed substantial agreement for most subjects. (Author)

  17. Developing and scoring essay tests.

    Science.gov (United States)

    Oermann, M

    1999-01-01

    The need to prepare nursing students for the licensing examination has resulted in a predominance of multiple-choice testing in nursing courses. But what about evaluating students' ability to present ideas in their own words and develop creative responses to questions posed by the teacher? Essay items provide an effective means of assessing higher levels of learning and ability to organize and present ideas in writing. The author describes how to develop essay items and score responses.

  18. Interpreting force concept inventory scores: Normalized gain and SAT scores

    Directory of Open Access Journals (Sweden)

    Vincent P. Coletta

    2007-05-01

    Full Text Available Preinstruction SAT scores and normalized gains (G on the force concept inventory (FCI were examined for individual students in interactive engagement (IE courses in introductory mechanics at one high school (N=335 and one university (N=292, and strong, positive correlations were found for both populations (r=0.57 and r=0.46, respectively. These correlations are likely due to the importance of cognitive skills and abstract reasoning in learning physics. The larger correlation coefficient for the high school population may be a result of the much shorter time interval between taking the SAT and studying mechanics, because the SAT may provide a more current measure of abilities when high school students begin the study of mechanics than it does for college students, who begin mechanics years after the test is taken. In prior research a strong correlation between FCI G and scores on Lawson’s Classroom Test of Scientific Reasoning for students from the same two schools was observed. Our results suggest that, when interpreting class average normalized FCI gains and comparing different classes, it is important to take into account the variation of students’ cognitive skills, as measured either by the SAT or by Lawson’s test. While Lawson’s test is not commonly given to students in most introductory mechanics courses, SAT scores provide a readily available alternative means of taking account of students’ reasoning abilities. Knowing the students’ cognitive level before instruction also allows one to alter instruction or to use an intervention designed to improve students’ cognitive level.

  19. Interpreting force concept inventory scores: Normalized gain and SAT scores

    Directory of Open Access Journals (Sweden)

    Jeffrey J. Steinert

    2007-05-01

    Full Text Available Preinstruction SAT scores and normalized gains (G on the force concept inventory (FCI were examined for individual students in interactive engagement (IE courses in introductory mechanics at one high school (N=335 and one university (N=292 , and strong, positive correlations were found for both populations ( r=0.57 and r=0.46 , respectively. These correlations are likely due to the importance of cognitive skills and abstract reasoning in learning physics. The larger correlation coefficient for the high school population may be a result of the much shorter time interval between taking the SAT and studying mechanics, because the SAT may provide a more current measure of abilities when high school students begin the study of mechanics than it does for college students, who begin mechanics years after the test is taken. In prior research a strong correlation between FCI G and scores on Lawson’s Classroom Test of Scientific Reasoning for students from the same two schools was observed. Our results suggest that, when interpreting class average normalized FCI gains and comparing different classes, it is important to take into account the variation of students’ cognitive skills, as measured either by the SAT or by Lawson’s test. While Lawson’s test is not commonly given to students in most introductory mechanics courses, SAT scores provide a readily available alternative means of taking account of students’ reasoning abilities. Knowing the students’ cognitive level before instruction also allows one to alter instruction or to use an intervention designed to improve students’ cognitive level.

  20. Assessment of Oral Skills: A Comparison of Scores Obtained through Audio Recording to Those Obtained through Face-to-Face Evaluation.

    Science.gov (United States)

    Nambiar, Mohana K; Goon, Cecilia

    1993-01-01

    The oral performance of a sample of 87 undergraduates was evaluated first in a face-to-face setting and then through audio recordings of that same performance. Results confirm that effectiveness in oral communication clearly is not dependent on words and sounds alone but that paralinguistic and extralinguistic data also play a significant role.…

  1. Gene expression profile study on osteoinductive effect of natural hydroxyapatite.

    Science.gov (United States)

    Lü, Xiaoying; Wang, Jiandan; Li, Bin; Zhang, Zhiwei; Zhao, Lifeng

    2014-08-01

    The aim of this study was to investigate the osteoinductive effect of natural hydroxyapatite (NHA). NHA was extracted from pig bones and prepared into disk-like samples. Then, proliferation of mouse bone mesenchymal stem cells (MSCs) cultured on NHA was assessed by the methylthiazoltetrazolium (MTT) assay. Furthermore, microarray technology was applied to obtain the gene expression profiles of MSCs cultured on NHA at 24, 48, and 72 h. The gene expression profile was then comprehensively analyzed by clustering, Gene Ontology (GO), Gene Microarray Pathway Profiler (GenMAPP) and Ingenuity Pathway Analysis (IPA). According to the results of microarray experiment, 8992 differentially expressed genes were obtained. 90 differential expressed genes related to HA osteogenic differentiation were determined by GO analysis. These genes included not only 6 genes related to HA osteogenic differentiation as mentioned in the literatures but also newly discovered 84 genes. Some important signaling pathways (TGF-β, MAPK, Wnt, etc.) were influenced by these genes. Gene interaction networks were obtained by IPA software, in which the scoring values of two networks were highest, and their main functions were related to cell development. The comprehensive analysis of these results indicate that NHA regulate some crucial genes (e.g., Bmp2, Spp1) and then activate some pathways such as TGF-β signaling pathway, and ultimately osteogenic differentiation was induced. © 2013 Wiley Periodicals, Inc.

  2. Perceived relative attractiveness of facial profiles with varying degrees of skeletal anomalies.

    Science.gov (United States)

    Hönn, Mirjam; Dietz, Klaus; Godt, Arnim; Göz, Gernot

    2005-05-01

    The objective of this study was to answer the following questions: Are profiles of Class I patients perceived as more attractive than profiles of Class II or Class III patients in Germany today? How pronounced must a skeletal malocclusion be to be perceived as less attractive? Are there differences in perception between dentists and laypersons? For the present study we examined seven patients with skeletal Class I, orthognathic maxillae and mandibles, and straight average faces (ideal biometric face as defined by A. M. Schwarz). Using the Onyx Ceph software, their profile lines were modified to reflect three different Class II profile variants and three different Class III profile variants. The 49 profiles thus obtained were assigned to two groups. Group 1 comprised the seven straight average faces and the first part of the retrognathic and prognathic profile variants. Group 2 comprised the same seven straight average faces and the remaining retrognathic and prognathic profile variants. Both groups of faces were scored by 130 laypersons and 126 dentists. Both groups of observers perceived the seven straight average faces similarly both in the first and second (subsequent) scoring rounds. The straight average face was perceived as most attractive by laypersons (mean, 5.48; 95% confidence interval (CI:) 5.33-5.60) and dentists (mean, 5.44; 95% CI, 5.28-5.50) alike, followed by the mildest variant of the retrognathic face (laypersons, mean, 4.85; 95% CI, 4.68-5.01; dentists, mean, 4.98; 95% CI, 4.81-5.10). Dentists differentiated more clearly by degree of skeletal malocclusion than did laypersons. Both groups alike perceived the extreme variant of the prognathic and retrognathic profile lines as the least attractive. Grouping the subjects by gender yielded only minor differences in perception. The straight average face is perceived as most attractive by representative German populations today. Dentists make clearer gradual distinctions in their perceptions than do

  3. A novel approach to selecting and weighting nutrients for nutrient profiling of foods and diets.

    Science.gov (United States)

    Arsenault, Joanne E; Fulgoni, Victor L; Hersey, James C; Muth, Mary K

    2012-12-01

    Nutrient profiling of foods is the science of ranking or classifying foods based on their nutrient composition. Most profiling systems use similar weighting factors across nutrients due to lack of scientific evidence to assign levels of importance to nutrients. Our aim was to use a statistical approach to determine the nutrients that best explain variation in Healthy Eating Index (HEI) scores and to obtain β-coefficients for the nutrients for use as weighting factors for a nutrient-profiling algorithm. We used a cross-sectional analysis of nutrient intakes and HEI scores. Our subjects included 16,587 individuals from the National Health and Nutrition Examination Survey 2005-2008 who were 2 years of age or older and not pregnant. Our main outcome measure was variation (R(2)) in HEI scores. Linear regression analyses were conducted with HEI scores as the dependent variable and all possible combinations of 16 nutrients of interest as independent variables, with covariates age, sex, and ethnicity. The analyses identified the best 1-nutrient variable model (with the highest R(2)), the best 2-nutrient variable model, and up to the best 16-nutrient variable model. The model with 8 nutrients explained 65% of the variance in HEI scores, similar to the models with 9 to 16 nutrients, but substantially higher than previous algorithms reported in the literature. The model contained five nutrients with positive β-coefficients (ie, protein, fiber, calcium, unsaturated fat, and vitamin C) and three nutrients with negative coefficients (ie, saturated fat, sodium, and added sugar). β-coefficients from the model were used as weighting factors to create an algorithm that generated a weighted nutrient density score representing the overall nutritional quality of a food. The weighted nutrient density score can be easily calculated and is useful for describing the overall nutrient quality of both foods and diets. Copyright © 2012 Academy of Nutrition and Dietetics. Published by

  4. The CAD-score web server: contact area-based comparison of structures and interfaces of proteins, nucleic acids and their complexes.

    Science.gov (United States)

    Olechnovič, Kliment; Venclovas, Ceslovas

    2014-07-01

    The Contact Area Difference score (CAD-score) web server provides a universal framework to compute and analyze discrepancies between different 3D structures of the same biological macromolecule or complex. The server accepts both single-subunit and multi-subunit structures and can handle all the major types of macromolecules (proteins, RNA, DNA and their complexes). It can perform numerical comparison of both structures and interfaces. In addition to entire structures and interfaces, the server can assess user-defined subsets. The CAD-score server performs both global and local numerical evaluations of structural differences between structures or interfaces. The results can be explored interactively using sortable tables of global scores, profiles of local errors, superimposed contact maps and 3D structure visualization. The web server could be used for tasks such as comparison of models with the native (reference) structure, comparison of X-ray structures of the same macromolecule obtained in different states (e.g. with and without a bound ligand), analysis of nuclear magnetic resonance (NMR) structural ensemble or structures obtained in the course of molecular dynamics simulation. The web server is freely accessible at: http://www.ibt.lt/bioinformatics/cad-score. © The Author(s) 2014. Published by Oxford University Press on behalf of Nucleic Acids Research.

  5. Photometric analysis of esthetically pleasant and unpleasant facial profile

    Directory of Open Access Journals (Sweden)

    Helena Nunes da Rocha Fortes

    2014-04-01

    Full Text Available Objective: To identify which linear, angular and proportionality measures could influence a profile to be considered esthetically pleasant or unpleasant, and to assess sexual dimorphism. Methods: 150 standardized facial profile photographs of dental students of both sexes were obtained and printed on photographic paper. Ten plastic surgeons, ten orthodontists and ten layperson answered a questionnaire characterizing each profile as pleasant, acceptable or unpleasant. With the use of a score system, the 15 most pleasant and unpleasant profiles of each sex were selected. The photographs were scanned into AutoCAD computer software. Linear, angular and proportion measurements were obtained using the software tools. The average values between groups were compared by the Student's t-test and the Mann-Whitney test at 5%. Results: The linear measures LL-S, LL-H, LL-E, LL-B and Pn-H showed statistically significant differences (p < 0.05. Statistical differences were also found in the angular measures G'.Pn.Pg', G'.Sn.Pg' and Sn.Me'.C and in the proportions G'-Sn:Sn-Me' and Sn-Gn':Gn'-C (p < 0.05. Differences between sexes were found for the linear measure Ala-Pn, angles G'-Pg'.N-Pn, Sn.Me'.C, and proportions Gn'-Sn:Sn-Me' and Ala-Pn:N'-Sn. (p < 0.05. Conclusion: The anteroposterior position of the lower lip, the amount of nose that influences the profile, facial convexity, total vertical proportion and lip-chin proportion appear to influence pleasantness of facial profile. Sexual dimorphism was identified in nasal length, nasofacial and lower third of the face angles, total vertical and nasal height/length proportions.

  6. PROFIL PROFESIONALISME GURU MADRASAH IBTIDAIYAH UNGGULAN DI JAKARTA SELATAN

    Directory of Open Access Journals (Sweden)

    Hasyim Asy'ari

    2016-02-01

    Full Text Available Abstract : This study aims at formulating a model of the profile of teachers professionalism of excellent Islamic Primary School (IPS. The source of data of this research is obtained from six excelence IPS in South Jakarta that achieve score of accreditation A.This research is a non experimental research that uses survey method. The population of this research is all teachers in 15 Excelence IPS with the sample as much as 40% of the teachers. as many as 100 teachers. As for the sampling technique used in this research is simple random sampling with descriptive statistics. The result of this research shows that firstly the profile of professionalism of the teachers of excellent IPS in South Jakarta is indicated by adequate teachers competency in personality, pedagogy, professionalism, and social aspect. Secondly, at the dimension of learning community teachers have not fully showed self development as a part of learning community. Thirdly, at the financial dimension it is know that the teachers of especially State Islamic Primary Schools are willing to accept all the policy of reward system set by the goverment and their schools headmasters. Fourtly, the linearity of educational background with the teaching profession. Fifthly, there is no difference in average scores the characteristics of profile of teachers professionalism between Private Islamic Primary Schools and the State ones. DOI: 10.15408/tjems.v1i1.1110

  7. Field evaluation of broiler gait score using different sampling methods

    Directory of Open Access Journals (Sweden)

    AFS Cordeiro

    2009-09-01

    Full Text Available Brazil is today the world's largest broiler meat exporter; however, in order to keep this position, it must comply with welfare regulations while maintaining low production costs. Locomotion problems restrain bird movements, limiting their access to drinking and feeding equipment, and therefore their survival and productivity. The objective of this study was to evaluate locomotion deficiency in broiler chickens reared under stressful temperature conditions using three different sampling methods of birds from three different ages. The experiment consisted in determining the gait score of 28, 35, 42 and 49-day-old broilers using three different known gait scoring methods: M1, birds were randomly selected, enclosed in a circle, and then stimulated to walk out of the circle; M2, ten birds were randomly selected and gait scored; and M3, birds were randomly selected, enclosed in a circle, and then observed while walking away from the circle without stimulus to walking. Environmental temperature, relative humidity, and light intensity inside the poultry houses were recorded. No evidence of interaction between scoring method and age was found however, both method and age influenced gait score. Gait score was found to be lower at 28 days of age. The evaluation using the ten randomly selected birds within the house was the method that presented the less reliable results. Gait score results when birds were stimulated to walk were lower than when they were not simulated, independently of age. The gait scores obtained with the three tested methods and ages were higher than those considered acceptable. The highest frequency of normal gait score (0 represented 50% of the flock. These results may be related to heat stress during rearing. Average gait score incresead with average ambient temperature, relative humidity, and light intensity. The evaluation of gait score to detect locomotion problems of broilers under rearing conditions seems subjective and

  8. The Thoracolumbar AOSpine Injury Score

    Science.gov (United States)

    Kepler, Christopher K.; Vaccaro, Alexander R.; Schroeder, Gregory D.; Koerner, John D.; Vialle, Luiz R.; Aarabi, Bizhan; Rajasekaran, Shanmuganathan; Bellabarba, Carlo; Chapman, Jens R.; Kandziora, Frank; Schnake, Klaus J.; Dvorak, Marcel F.; Reinhold, Max; Oner, F. Cumhur

    2015-01-01

    Study Design Survey of 100 worldwide spine surgeons. Objective To develop a spine injury score for the AOSpine Thoracolumbar Spine Injury Classification System. Methods Each respondent was asked to numerically grade the severity of each variable of the AOSpine Thoracolumbar Spine Injury Classification System. Using the results, as well as limited input from the AOSpine Trauma Knowledge Forum, the Thoracolumbar AOSpine Injury Score was developed. Results Beginning with 1 point for A1, groups A, B, and C were consecutively awarded an additional point (A1, 1 point; A2, 2 points; A3, 3 points); however, because of a significant increase in the severity between A3 and A4 and because the severity of A4 and B1 was similar, both A4 and B1 were awarded 5 points. An uneven stepwise increase in severity moving from N0 to N4, with a substantial increase in severity between N2 (nerve root injury with radicular symptoms) and N3 (incomplete spinal cord injury) injuries, was identified. Hence, each grade of neurologic injury was progressively given an additional point starting with 0 points for N0, and the substantial difference in severity between N2 and N3 injuries was recognized by elevating N3 to 4 points. Finally, 1 point was awarded to the M1 modifier (indeterminate posterolateral ligamentous complex injury). Conclusion The Thoracolumbar AOSpine Injury Score is an easy-to-use, data-driven metric that will allow for the development of a surgical algorithm to accompany the AOSpine Thoracolumbar Spine Injury Classification System. PMID:27190734

  9. Scores on the eysenck personality questionnaire for a sample of children and adolescents receiving psychological treatment in Puerto Rico.

    Science.gov (United States)

    Porrata, Jose Luis; Rosa, Abraham; Mendez, Viviana

    2003-08-01

    Personality questionnaire scores obtained by children and adolescents (n = 28) receiving psychological treatment at a health facility in Humacao, Puerto Rico were examined. The scores were compared with those of regular school children of the same age, of Gurabo, Puerto Rico, who were not in treatment (n = 30). The children in treatment obtained higher scores on Psychoticism, lower scores on Extraversion, and similar scores on Neuroticism and Dissimulation by comparison with regular students.

  10. Differences in behavioral characteristics between dogs obtained as puppies from pet stores and those obtained from noncommercial breeders.

    Science.gov (United States)

    McMillan, Franklin D; Serpell, James A; Duffy, Deborah L; Masaoud, Elmabrok; Dohoo, Ian R

    2013-05-15

    To compare the owner-reported prevalence of behavioral characteristics in dogs obtained as puppies from pet stores with that of dogs obtained as puppies from noncommercial breeders. Cross-sectional study. Animals-Dogs obtained as puppies from pet stores (n = 413) and breeder-obtained dogs (5,657). Behavioral evaluations were obtained from a large convenience sample of current dog owners with the online version of the Canine Behavioral Assessment and Research Questionnaire, which uses ordinal scales to rate either the intensity or frequency of the dogs' behavior. Hierarchic linear and logistic regression models were used to analyze the effects of source of acquisition on behavioral outcomes when various confounding and intervening variables were controlled for. Pet store-derived dogs received significantly less favorable scores than did breeder-obtained dogs on 12 of 14 of the behavioral variables measured; pet store dogs did not score more favorably than breeder dogs in any behavioral category. Compared with dogs obtained as puppies from noncommercial breeders, dogs obtained as puppies from pet stores had significantly greater aggression toward human family members, unfamiliar people, and other dogs; greater fear of other dogs and nonsocial stimuli; and greater separation-related problems and house soiling. Obtaining dogs from pet stores versus noncommercial breeders represented a significant risk factor for the development of a wide range of undesirable behavioral characteristics. Until the causes of the unfavorable differences detected in this group of dogs can be specifically identified and remedied, the authors cannot recommend that puppies be obtained from pet stores.

  11. Proxy measures of household food consumption for food security assessment and surveillance: comparison of the household dietary diversity and food consumption scores.

    Science.gov (United States)

    Kennedy, Gina; Berardo, Andrea; Papavero, Cinzia; Horjus, Peter; Ballard, Terri; Dop, MarieClaude; Delbaere, Jan; Brouwer, Inge D

    2010-12-01

    To provide an overview of the household dietary diversity score and the food consumption score, two indicators used for food security assessment and surveillance, and compare their performance in food security assessments in three countries. Cross-sectional cluster sampling design using an interview-administered structured questionnaire on household food security, including household-level food group consumption measured over 1 d and 7 d. Survey data are from Burkina Faso, Lao People's Democratic Republic (Lao PDR) and northern Uganda. Households in Burkina Faso (n 3640), Lao PDR (n 3913) and northern Uganda (n 1956). Spearman's correlation coefficients between the scores were 0·73 in Burkina Faso, 0·65 in Lao PDR and 0·53 in northern Uganda. Prevalence-adjusted kappa coefficients showed substantial strength of agreement in two countries. The proportion of agreement between the two scores ranged from 85 % in Lao PDR to 65 % in northern Uganda. Dietary profiles based on food group consumption using score tertiles were comparable. Rankings of the most food-insecure areas within a country corresponded well in northern Uganda and Burkina Faso but not in Lao PDR. Both indicators showed moderate correlations with other proxy measures of food security. The comparative study highlights the similarities and differences between the food consumption and household dietary diversity scores. Similar classification of the most food-insecure areas within sub-national levels was obtained. The choice of indicator for food security assessment and surveillance will vary depending on user needs.

  12. Dynamic Measurement of Disease Activity in Acute Pancreatitis: The Pancreatitis Activity Scoring System.

    Science.gov (United States)

    Wu, Bechien U; Batech, Michael; Quezada, Michael; Lew, Daniel; Fujikawa, Kelly; Kung, Jonathan; Jamil, Laith H; Chen, Wansu; Afghani, Elham; Reicher, Sonya; Buxbaum, James; Pandol, Stephen J

    2017-07-01

    Acute pancreatitis has a highly variable course. Currently there is no widely accepted method to measure disease activity in patients hospitalized for acute pancreatitis. We aimed to develop a clinical activity index that incorporates routine clinical parameters to assist in the measurement, study, and management of acute pancreatitis. We used the UCLA/RAND appropriateness method to identify items for inclusion in the disease activity instrument. We conducted a systematic literature review followed by two sets of iterative modified Delphi meetings including a panel of international experts between November 2014 and November 2015. The final instrument was then applied to patient data obtained from five separate study cohorts across Southern California to assess profiles of disease activity. From a list of 35 items comprising 6 domains, we identified 5 parameters for inclusion in the final weighted clinical activity scoring system: organ failure, systemic inflammatory response syndrome, abdominal pain, requirement for opiates and ability to tolerate oral intake. We applied the weighted scoring system across the 5 study cohorts comprising 3,123 patients. We identified several distinct patterns of disease activity: (i) overall there was an elevated score at baseline relative to discharge across all study cohorts, (ii) there were distinct patterns of disease activity related to duration of illness as well as (iii) early and persistent elevation of disease activity among patients with severe acute pancreatitis defined as persistent organ failure. We present the development and initial validation of a clinical activity score for real-time assessment of disease activity in patients with acute pancreatitis.

  13. Scoring function to predict solubility mutagenesis

    Directory of Open Access Journals (Sweden)

    Deutsch Christopher

    2010-10-01

    Full Text Available Abstract Background Mutagenesis is commonly used to engineer proteins with desirable properties not present in the wild type (WT protein, such as increased or decreased stability, reactivity, or solubility. Experimentalists often have to choose a small subset of mutations from a large number of candidates to obtain the desired change, and computational techniques are invaluable to make the choices. While several such methods have been proposed to predict stability and reactivity mutagenesis, solubility has not received much attention. Results We use concepts from computational geometry to define a three body scoring function that predicts the change in protein solubility due to mutations. The scoring function captures both sequence and structure information. By exploring the literature, we have assembled a substantial database of 137 single- and multiple-point solubility mutations. Our database is the largest such collection with structural information known so far. We optimize the scoring function using linear programming (LP methods to derive its weights based on training. Starting with default values of 1, we find weights in the range [0,2] so that predictions of increase or decrease in solubility are optimized. We compare the LP method to the standard machine learning techniques of support vector machines (SVM and the Lasso. Using statistics for leave-one-out (LOO, 10-fold, and 3-fold cross validations (CV for training and prediction, we demonstrate that the LP method performs the best overall. For the LOOCV, the LP method has an overall accuracy of 81%. Availability Executables of programs, tables of weights, and datasets of mutants are available from the following web page: http://www.wsu.edu/~kbala/OptSolMut.html.

  14. Best waveform score for diagnosing keratoconus

    Directory of Open Access Journals (Sweden)

    Allan Luz

    2013-12-01

    Full Text Available PURPOSE: To test whether corneal hysteresis (CH and corneal resistance factor (CRF can discriminate between keratoconus and normal eyes and to evaluate whether the averages of two consecutive measurements perform differently from the one with the best waveform score (WS for diagnosing keratoconus. METHODS: ORA measurements for one eye per individual were selected randomly from 53 normal patients and from 27 patients with keratoconus. Two groups were considered the average (CH-Avg, CRF-Avg and best waveform score (CH-WS, CRF-WS groups. The Mann-Whitney U-test was used to evaluate whether the variables had similar distributions in the Normal and Keratoconus groups. Receiver operating characteristics (ROC curves were calculated for each parameter to assess the efficacy for diagnosing keratoconus and the same obtained for each variable were compared pairwise using the Hanley-McNeil test. RESULTS: The CH-Avg, CRF-Avg, CH-WS and CRF-WS differed significantly between the normal and keratoconus groups (p<0.001. The areas under the ROC curve (AUROC for CH-Avg, CRF-Avg, CH-WS, and CRF-WS were 0.824, 0.873, 0.891, and 0.931, respectively. CH-WS and CRF-WS had significantly better AUROCs than CH-Avg and CRF-Avg, respectively (p=0.001 and 0.002. CONCLUSION: The analysis of the biomechanical properties of the cornea through the ORA method has proved to be an important aid in the diagnosis of keratoconus, regardless of the method used. The best waveform score (WS measurements were superior to the average of consecutive ORA measurements for diagnosing keratoconus.

  15. Sensitivity, Specificity and Reliability of the RIPASA Score for Diagnosis of Acute Appendicitis in Relation to the Alvarado Score.

    Science.gov (United States)

    Arroyo-Rangel, Celerino; Limón, Iván O; Vera, Ángel G; Guardiola, Pedro M; Sánchez-Valdivieso, Enrique A

    2018-02-24

    In order to avoid delay in the diagnosis of acute appendicitis and reduce the margin of error, the use of scales has been used. The aim of this study was to compare the effectiveness of the Alvarado and RIPASA scores in the clinical diagnosis of acute appendicitis and to correlate with the histopathological results. Prospective, longitudinal, analytical, comparative and observational study. Patients with abdominal pain syndrome suggestive of acute appendicitis and submitted to surgical intervention were included; the Alvarado and RIPASA scores were simultaneously applied. The pathology report was obtained and the efficacy of both scores for the diagnosis of acute appendicitis was compared. One hundred patients were included. It was shown that the RIPASA score demonstrated greater diagnostic accuracy compared to the Alvarado score, with sensitivity of 98,8% and specificity of 71,4% versus 90,7% and 64,3%, respectively. The RIPASA score showed an area under the curve of 0,88 and the Alvarado scale of 0,80. The RIPASA score is a more specific, convenient and accurate system than the Alvarado score for the Mexican population. Copyright © 2017 AEC. Publicado por Elsevier España, S.L.U. All rights reserved.

  16. TS-Chemscore, a Target-Specific Scoring Function, Significantly Improves the Performance of Scoring in Virtual Screening.

    Science.gov (United States)

    Wang, Wen-Jing; Huang, Qi; Zou, Jun; Li, Lin-Li; Yang, Sheng-Yong

    2015-07-01

    Most of the scoring functions currently used in structure-based drug design belong to 'universal' scoring functions, which often give a poor correlation between the calculated scores and experimental binding affinities. In this investigation, we proposed a simple strategy to construct target-specific scoring functions based on known 'universal' scoring functions. This strategy was applied to Chemscore, a widely used empirical scoring function, which led to a new scoring function, termed TS-Chemscore. TS-Chemscore was validated on 14 protein targets, which cover a wide range of biological target categories. The results showed that TS-Chemscore significantly improved the correlation between the calculated scores and experimental binding affinities compared with the original Chemscore. TS-Chemscore was then applied in virtual screening to retrieve novel JAK3 and YopH inhibitors. Top 30 compounds for each target were selected for experimental validation. Six active compounds for JAK3 and four for YopH were obtained. These compounds were out of the lists of top 30 compounds sorted by Chemscore. Collectively, TS-Chemscore established in this study showed a better performance in virtual screening than its counterpart Chemscore. © 2014 John Wiley & Sons A/S.

  17. PROCAM-, FRAMINGHAM-, SCORE- and SMART-risk score for predicting cardiovascular morbidity and mortality in patients with overt atherosclerosis.

    Science.gov (United States)

    Uthoff, H; Staub, D; Socrates, T; Meyerhans, A; Bundi, B; Schmid, H P; Frauchiger, B

    2010-11-01

    The predictive value of PROCAM, FRAMINGHAM, SCORE and SMART-score to estimate the cardiovascular risk in patients with overt atherosclerosis had never been assessed. 96 consecutive patients with clinically evident atherosclerosis (coronary, cerebrovascular, peripheral artery and renovascular disease) were enrolled in this preliminary observational study. At baseline, medical history and blood chemistry were obtained. Sonographic measurement of the intima-media thickness (IMT) in the common carotid artery was performed and risk estimations according to the above listed risk scores were calculated. During a 6 year follow-up the occurrence of cardiovascular death, acute coronary syndrome and stroke was assessed. Mean (±SD) risk-scores were 10.9±2.5, range 6-17 (SMART); 18.9±18.2%; range 0.2-94.1% (PROCAM); 21.4±13.1%, range 4-56% (FRAMINGHAM); and 4.8±3.9%, range 0.4-15.3% (SCORE). Mean IMT was 0.84±0.14 mm, range 0.51-1.20 mm. All scores correlate significantly with each other (r>0.321; pcardiovascular endpoint was observed in 36 (42%) patients. The AUC (95% confidence interval) for SMART-risk-score predicting a cardiovascular event was 0.67 (0.54-0.77; pcardiovascular event per additional SMART score point of 1.15 (95% CI 1.01-1.30 p=0.03). PROCAM-, FRAMINGHAM- and SCORE-risk score seem to be barely useful in a secondary prevention setting. In patients with overt atherosclerosis, the cardiovascular risk seems to be better assessed by means of the SMART score.

  18. Cohort Profile

    DEFF Research Database (Denmark)

    Christensen, Gunhild Tidemann; Molbo, Drude; Ängquist, Lars Henrik

    2015-01-01

    years, to be assessed for military service. The DCD was established by digitizing information from conscription board register cards on the height, weight, educational level, intelligence test score and examination details of Danish conscripts. The DCD contains information on 728 160 men born from 1939...

  19. Norm Scores of the Box and Block Test for Children Ages 3-10 Years

    NARCIS (Netherlands)

    Jongbloed-Pereboom, M.; Nijhuis-Van der Sanden, M.W.G.; Steenbergen, B.

    2013-01-01

    This study provides new norm scores for the Box and Block Test for gross manual dexterity in children ages 3-10 yr. Two hundred fifteen Dutch children performed the Box and Block Test separately with each hand. We found an age effect for the scores; older children obtained higher scores than younger

  20. Norm scores of the box and block test for children ages 3-10 years

    NARCIS (Netherlands)

    Jongbloed-Pereboom, M.; Nijhuis-Van der Sanden, M.W.G.; Steenbergen, B.

    2013-01-01

    This study provides new norm scores for the Box and Block Test for gross manual dexterity in children ages 3-10 yr. Two hundred fifteen Dutch children performed the Box and Block Test separately with each hand. We found an age effect for the scores; older children obtained higher scores than younger

  1. Fellow Profile

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 1971 Section: Chemistry. Narasimhan, Prof. Palliakaranai Thirumalai Ph.D. (Madras), FNA, FNASc. Date of birth: 28 July 1928. Date of death: 3 May 2013. Specialization: Theoretical Chemistry and Magnetic Resonance Last known address: 1013, Lupine Drive, Sunnyvale, CA 94086, USA. YouTube ...

  2. Profile Analysis of the Universal Nonverbal Intelligence Test Standardization Sample.

    Science.gov (United States)

    Wilhoit, Brian E.; McCallum, R. Steve

    2002-01-01

    A normative typology was developed and applied using multivariate profile analysis of subtest scores of the Universal Nonverbal Intelligence Test (UNIT) standardization sample. The results yielded a seven-profile cluster solution for the Extended Battery, and a six-profile cluster solution for the Standard Battery. Additionally, the results lend…

  3. Adaptation profiles comprising objective and subjective measures in fibromyalgia: the al-Ándalus project.

    Science.gov (United States)

    Estévez-López, Fernando; Segura-Jiménez, Víctor; Álvarez-Gallardo, Inmaculada C; Borges-Cosic, Milkana; Pulido-Martos, Manuel; Carbonell-Baeza, Ana; Aparicio, Virginia A; Geenen, Rinie; Delgado-Fernández, Manuel

    2017-11-01

    The aim of this study was to identify subgroups in terms of adaptation to FM and to test differences in FM severity between these subgroups. The al-Ándalus project made it possible to perform a comprehensive population-based cross-sectional study in 486 FM patients including multiple assessments of modifiable (could be targeted in therapy) resilience and vulnerability factors, measured by objective and subjective assessments, related to psychological and physical function. FM severity was assessed by means of FM impact (total score of the Revised Fibromyalgia Impact Questionnaire) and distress (Polysymptomatic Distress Scale of the modified 2011 preliminary criteria for FM). Exploratory factor analysis, cluster analysis and analysis of variance were conducted. Factor analysis yielded eight factors: three included objective measures (declarative memory, active lifestyle and objective physical fitness) and five included subjective measures (fatigue, psychological distress, catastrophizing, resilience and subjective physical fitness). Cluster analysis based on these eight factors identified five profiles: Adapted (16%), Fit (18%), Poor performer (20%), Positive (20%) and Maladapted (26%). Most profile comparisons revealed different levels of FM severity varying from Adapted (the most favourable profile) to Maladapted (the most unfavourable profile) with Fit, Poor performer and Positive obtaining intermediate positions. Heterogeneity of FM was shown by five clinically meaningful profiles of modifiable factors that were associated with FM severity. It is of clinical interest to examine whether these profiles are associated with FM prognosis and the effectiveness of interventions, which would enhance the development of customized interventions based on adaptation profiles in FM.

  4. Fetal bone age revisited: proposal of a new radiographic score

    Energy Technology Data Exchange (ETDEWEB)

    Stempfle, N. [Dept. of Radiology, R. Debre Hospital, 75 - Paris (France); Huten, Y. [Dept. of Developmental Biology, R. Debre Hospital, 75 - Paris (France); Fondacci, C. [Dept. of Developmental Biology, R. Debre Hospital, 75 - Paris (France); Lang, T. [Dept. of Statistics, Univ. of Pitie-Salpetriere, 75 - Paris (France); Hassan, T. [Dept. of Radiology, R. Debre Hospital, 75 - Paris (France); Nessmann, C. [Dept. of Developmental Biology, R. Debre Hospital, 75 - Paris (France)

    1995-09-01

    In order to establish a fetal bone age score, the post-mortem skeletal radiographs of 85 selected normal fetuses aged from 15 to 41 weeks of gestation (WG) were analysed. Twenty-eight skeletal areas were selected for which quantitative and/or qualitative criteria were defined. Each new aspect was graded and statistically tested by the stepwise linear regression method. Two modalities of scores of decreasing complexity were then designed. The use of these two scores permitted the assessment of the fetal age with r{sup 2} values of 0.97 and 0.96 (standard error of estimation of 1.19 and 1.36 WG). Applied to 15 intrauterine growth retardation (IUGR) fetuses, the age estimated by these scores was well correlated with the age obtained by extraosseous criteria of maturation. This method is proposed as a tool for determining the fetal age during necropsy and could also be useful in US prenatal evaluation. (orig.)

  5. Metagenome Fragment Classification Using -Mer Frequency Profiles

    Directory of Open Access Journals (Sweden)

    Gail Rosen

    2008-01-01

    Full Text Available A vast amount of microbial sequencing data is being generated through large-scale projects in ecology, agriculture, and human health. Efficient high-throughput methods are needed to analyze the mass amounts of metagenomic data, all DNA present in an environmental sample. A major obstacle in metagenomics is the inability to obtain accuracy using technology that yields short reads. We construct the unique -mer frequency profiles of 635 microbial genomes publicly available as of February 2008. These profiles are used to train a naive Bayes classifier (NBC that can be used to identify the genome of any fragment. We show that our method is comparable to BLAST for small 25 bp fragments but does not have the ambiguity of BLAST's tied top scores. We demonstrate that this approach is scalable to identify any fragment from hundreds of genomes. It also performs quite well at the strain, species, and genera levels and achieves strain resolution despite classifying ubiquitous genomic fragments (gene and nongene regions. Cross-validation analysis demonstrates that species-accuracy achieves 90% for highly-represented species containing an average of 8 strains. We demonstrate that such a tool can be used on the Sargasso Sea dataset, and our analysis shows that NBC can be further enhanced.

  6. Normative nasalance scores for Vietnamese-speaking children.

    Science.gov (United States)

    Nguyen, Van Thai; Lehes, Lagle; Truong, Thi Thuy Hang; Hoang, Thi Van Anh; Jagomägi, Triin

    2017-10-26

    The Nasometer is increasingly being used to complement auditory perceptual assessment of nasality. Nasalance scores which are obtained from the Nasometer vary across languages. Normative nasalance scores have been established for many languages but not for the Vietnamese language. The objective of this study was to obtain the normative nasalance scores for Vietnamese-speaking children. In this study, 102 healthy Vietnamese children speaking in the central regional dialect aged from 7 to 9 years (45 boys, 57 girls; mean age = 7.5 years) at a primary school in Hue, Vietnam participated. Three speech stimuli, which were specific for the Vietnamese language, were designed: oral stimuli (19 words and 18 sentences), oro-nasal stimuli (eight sentences) and nasal stimuli (seven sentences). The children were asked to repeat these stimuli after the examiner. The Nasometer II (model 6450) was used to obtain the nasalance scores. The procedure took about 10 minutes for each child. The mean nasalance scores and the standard deviation of each stimulus were: 13.1 ± 5.8 (oral stimuli), 30.7 ± 6.6 (oro-nasal stimuli) and 56.9 ± 9.2 (nasal stimuli). No significant differences between the genders were found. The normative nasalance scores provide essential reference information for clinicians who deal with nasalance disorders, especially patients with cleft palate. The nasalance scores in this study were established for Vietnamese children speaking in the central regional dialect and can be applied to both genders.

  7. [Neuropsychological profile of internationally adopted children in Catalonia].

    Science.gov (United States)

    Callejón-Póo, L; Boix, C; López-Sala, A; Colomé, R; Fumadó, V; Sans, A

    2012-01-01

    During the last years, International adoption has increased significantly in our country over the last few years. China, Russia, Colombia and Ethiopia represent 77% of international adoptions in Spain. Cognitive and behavioural aspects are very important for an adequate social, family and school integration of these children. To describe the neuropsychological profiles of a group of internationally adopted children in Catalonia from China, Russia, Colombia and Ethiopia. Neuropsychological examination of 49 children from international adoption (6 of Chinese origin, 24 from Russia, 13 from Colombia and 6 of Ethiopian origin). The group of Chinese origin obtained average scores of all functions evaluated. The Russian origin group was below the average for, selective attention, phonetic verbal fluency, control of impulsivity, mechanics and reading comprehension, and spelling. Scores on the impulse control in the Colombian origin group were below average. The group of Ethiopian origin obtained average scores in all functions evaluated except for spelling difficulties. Children adopted from Russia have greater neuropsychological difficulties than the others. Most pre-adoption history is unknown; therefore we are unable to determine the origin of these difficulties. Maternal alcohol consumption during pregnancy and the institutional environment could be influencing factors in neuropsychological delay. Inclusion of neuropsychological assessment in health protocols for these children is recommended if they develop suggestive signs of cognitive and/or behavioral impairment. Copyright © 2011 Asociación Española de Pediatría. Published by Elsevier Espana. All rights reserved.

  8. Using the profile method for evaluationthe beer quality

    Directory of Open Access Journals (Sweden)

    O. Bocharova

    2017-04-01

    Full Text Available The expediency of using the profile method of analysis for assessing the influence of technological factors on the quality of beer has been established. The characteristics for the evaluation of beer quality by the profile method are chosen. The results obtained using the profile method give a more complete picture of the properties of beer than the results of the scoring method. Each of the samples was analyzed and studied. The results of analysis of such criteria as aroma, flavor, appearance and physicochemical parameters are demonstrated on profilograms. Estimation of flavor is the most difficult, since this concept includes a complex sensation of taste, aroma and consistency, determined in the oral cavity. To confirm the organoleptic properties of the «body» of the best sort of beer, rheological analysis data were presented. Such an integrated approach will allow fully studying the properties of a low-alcohol beverage and clearly demonstrating the advantages of a profile method of analysis.

  9. Motivating High School Students to Score Proficient on State Tests

    Science.gov (United States)

    Brown, Sarah Lee

    2015-01-01

    The researcher interviewed two groups of eleventh grade students, in a rural Appalachian setting, who tended to score low on the state mandated high stakes/low stakes test to discover their efforts on the test, specifically in reading, and to obtain their opinions concerning the effects of a specific incentive or consequence. Before the eleventh…

  10. Dietary Diversity Scores and Nutritional Status of Breastfeeding ...

    African Journals Online (AJOL)

    Structured pretested questionnaires were used to collect information on 24-hour dietary intake as well as some socioeconomic and socio demographic factors. Information on Dietary Diversity Score (DDS) representing the number of food groups consumed over a 24 hour period was obtained using Food and Nutrition on ...

  11. Student Laptop Use and Scores on Standardized Tests

    Science.gov (United States)

    Kposowa, Augustine J.; Valdez, Amanda D.

    2013-01-01

    Objectives: The primary objective of the study was to investigate the relationship between ubiquitous laptop use and academic achievement. It was hypothesized that students with ubiquitous laptops would score on average higher on standardized tests than those without such computers. Methods: Data were obtained from two sources. First, demographic…

  12. Discrepancy between clinician and research assistant in TIMI score calculation (TRIAGED CPU).

    Science.gov (United States)

    Taylor, Brian T; Mancini, Michelino

    2015-01-01

    Several studies have attempted to demonstrate that the Thrombolysis in Myocardial Infarction (TIMI) risk score has the ability to risk stratify emergency department (ED) patients with potential acute coronary syndromes (ACS). Most of the studies we reviewed relied on trained research investigators to determine TIMI risk scores rather than ED providers functioning in their normal work capacity. We assessed whether TIMI risk scores obtained by ED providers in the setting of a busy ED differed from those obtained by trained research investigators. This was an ED-based prospective observational cohort study comparing TIMI scores obtained by 49 ED providers admitting patients to an ED chest pain unit (CPU) to scores generated by a team of trained research investigators. We examined provider type, patient gender, and TIMI elements for their effects on TIMI risk score discrepancy. Of the 501 adult patients enrolled in the study, 29.3% of TIMI risk scores determined by ED providers and trained research investigators were generated using identical TIMI risk score variables. In our low-risk population the majority of TIMI risk score differences were small; however, 12% of TIMI risk scores differed by two or more points. TIMI risk scores determined by ED providers in the setting of a busy ED frequently differ from scores generated by trained research investigators who complete them while not under the same pressure of an ED provider.

  13. Discrepancy Between Clinician and Research Assistant in TIMI Score Calculation (TRIAGED CPU

    Directory of Open Access Journals (Sweden)

    Taylor, Brian T.

    2014-11-01

    Full Text Available Introduction: Several studies have attempted to demonstrate that the Thrombolysis in Myocardial Infarction (TIMI risk score has the ability to risk stratify emergency department (ED patients with potential acute coronary syndromes (ACS. Most of the studies we reviewed relied on trained research investigators to determine TIMI risk scores rather than ED providers functioning in their normal work capacity. We assessed whether TIMI risk scores obtained by ED providers in the setting of a busy ED differed from those obtained by trained research investigators. Methods: This was an ED-based prospective observational cohort study comparing TIMI scores obtained by 49 ED providers admitting patients to an ED chest pain unit (CPU to scores generated by a team of trained research investigators. We examined provider type, patient gender, and TIMI elements for their effects on TIMI risk score discrepancy. Results: Of the 501 adult patients enrolled in the study, 29.3% of TIMI risk scores determined by ED providers and trained research investigators were generated using identical TIMI risk score variables. In our low-risk population the majority of TIMI risk score differences were small; however, 12% of TIMI risk scores differed by two or more points. Conclusion: TIMI risk scores determined by ED providers in the setting of a busy ED frequently differ from scores generated by trained research investigators who complete them while not under the same pressure of an ED provider. [West J Emerg Med. 2015;16(1:24–33.

  14. The Apgar score has survived the test of time.

    Science.gov (United States)

    Finster, Mieczyslaw; Wood, Margaret

    2005-04-01

    In 1953, Virginia Apgar, M.D. published her proposal for a new method of evaluation of the newborn infant. The avowed purpose of this paper was to establish a simple and clear classification of newborn infants which can be used to compare the results of obstetric practices, types of maternal pain relief and the results of resuscitation. Having considered several objective signs pertaining to the condition of the infant at birth she selected five that could be evaluated and taught to the delivery room personnel without difficulty. These signs were heart rate, respiratory effort, reflex irritability, muscle tone and color. Sixty seconds after the complete birth of the baby a rating of zero, one or two was given to each sign, depending on whether it was absent or present. Virginia Apgar reviewed anesthesia records of 1025 infants born alive at Columbia Presbyterian Medical Center during the period of this report. All had been rated by her method. Infants in poor condition scored 0-2, infants in fair condition scored 3-7, while scores 8-10 were achieved by infants in good condition. The most favorable score 1 min after birth was obtained by infants delivered vaginally with the occiput the presenting part (average 8.4). Newborns delivered by version and breech extraction had the lowest score (average 6.3). Infants delivered by cesarean section were more vigorous (average score 8.0) when spinal was the method of anesthesia versus an average score of 5.0 when general anesthesia was used. Correlating the 60 s score with neonatal mortality, Virginia found that mature infants receiving 0, 1 or 2 scores had a neonatal death rate of 14%; those scoring 3, 4, 5, 6 or 7 had a death rate of 1.1%; and those in the 8-10 score group had a death rate of 0.13%. She concluded that the prognosis of an infant is excellent if he receives one of the upper three scores, and poor if one of the lowest three scores.

  15. Exploring the ResearchGate score as an academic metric: reflections and implications for practice

    OpenAIRE

    Jordan, Katherine

    2015-01-01

    This paper presents a response to the paper ‘A critical look at the ResearchGate score as a measure of scientific reputation’. Following up on arguments presented by the authors, which argue that the ResearchGate score is irreproducible and dependent upon Journal Impact Factors, a small-scale exploratory analysis of ResearchGate scores was undertaken to examine correlations between ResearchGate score and profile metrics. The importance of the Journal Impact Factor in determining ResearchGate ...

  16. Dosimetric Algorithm to Reproduce Isodose Curves Obtained from a LINAC

    Directory of Open Access Journals (Sweden)

    Julio Cesar Estrada Espinosa

    2014-01-01

    Full Text Available In this work isodose curves are obtained by the use of a new dosimetric algorithm using numerical data from percentage depth dose (PDD and the maximum absorbed dose profile, calculated by Monte Carlo in a 18 MV LINAC. The software allows reproducing the absorbed dose percentage in the whole irradiated volume quickly and with a good approximation. To validate results an 18 MV LINAC with a whole geometry and a water phantom were constructed. On this construction, the distinct simulations were processed by the MCNPX code and then obtained the PDD and profiles for the whole depths of the radiation beam. The results data were used by the code to produce the dose percentages in any point of the irradiated volume. The absorbed dose for any voxel’s size was also reproduced at any point of the irradiated volume, even when the voxels are considered to be of a pixel’s size. The dosimetric algorithm is able to reproduce the absorbed dose induced by a radiation beam over a water phantom, considering PDD and profiles, whose maximum percent value is in the build-up region. Calculation time for the algorithm is only a few seconds, compared with the days taken when it is carried out by Monte Carlo.

  17. Dosimetric algorithm to reproduce isodose curves obtained from a LINAC.

    Science.gov (United States)

    Estrada Espinosa, Julio Cesar; Martínez Ovalle, Segundo Agustín; Pereira Benavides, Cinthia Kotzian

    2014-01-01

    In this work isodose curves are obtained by the use of a new dosimetric algorithm using numerical data from percentage depth dose (PDD) and the maximum absorbed dose profile, calculated by Monte Carlo in a 18 MV LINAC. The software allows reproducing the absorbed dose percentage in the whole irradiated volume quickly and with a good approximation. To validate results an 18 MV LINAC with a whole geometry and a water phantom were constructed. On this construction, the distinct simulations were processed by the MCNPX code and then obtained the PDD and profiles for the whole depths of the radiation beam. The results data were used by the code to produce the dose percentages in any point of the irradiated volume. The absorbed dose for any voxel's size was also reproduced at any point of the irradiated volume, even when the voxels are considered to be of a pixel's size. The dosimetric algorithm is able to reproduce the absorbed dose induced by a radiation beam over a water phantom, considering PDD and profiles, whose maximum percent value is in the build-up region. Calculation time for the algorithm is only a few seconds, compared with the days taken when it is carried out by Monte Carlo.

  18. Normal range MMPI-A profiles among psychiatric inpatients.

    Science.gov (United States)

    Hilts, Darolyn; Moore, James M

    2003-09-01

    The present study examined the base rates of normal range Minnesota Multiphasic Personality Inventory-Adolescent (MMPI-A) profiles in an inpatient sample and examined the differences between adolescents with apparently valid normal range profiles (all clinical scale T-scores MMPI-A validity scale scores and other indexes of underreporting. Normal range profiles cannot be adequately explained by a less pathological history prior to hospitalization or by defensiveness. Thirty percent of male and 25% of female adolescents produced valid MMPI-A profiles in which none of the clinical scales were elevated. Both male and female adolescents with normal range profiles were generally less likely to report internalizing symptoms than those with elevated profiles, but both groups report externalizing symptoms. Neither the standard MMPI-A validity scales nor additional validity scales discriminated between profile groups. Clinicians should not assume that normal range profiles indicate an absence of problems.

  19. Relationship between patients' oral health-related quality of life, satisfaction with dentition, and personality profiles.

    Science.gov (United States)

    Karasneh, Jumana; Al-Omiri, Mahmoud K; Al-Hamad, Khaled Q; Al Quran, Firas A M

    2009-11-01

    The aim of this study was to investigate the relationship between patients' oral health-related quality of life, satisfaction with their dentition, and their personality profiles. Eighty-four patients (30 males and 54 females; mean age 31.9+/-12.7 years) seeking routine dental treatment were recruited for this study. A "Dental Impact on Daily Living" (DIDL) questionnaire was used to assess dental satisfaction and impact on daily living. An "Oral Health Impact Profile" (OHIP) was used to measure self-reported discomfort, disability, and dysfunction caused by oral conditions. Oral health-related quality of life was assessed using the "United Kingdom Oral Health Related Quality of Life" measure (OHQoL-U.K). A "NEO Five Factor inventory" (NEO-FFI) was used to assess personality profiles. The dentition has a measurable impact on daily living as well as with satisfaction with appearance, pain levels, oral comfort, general performance, and eating capability (p=0.000). Younger patients had more profound oral health impacts (p=0.045) and higher neuroticism scores (0.043). OHIP scores were significantly related to OHQoL-UK scores (p=0.000). DIDL scores had significant correlations with OHIP and OHQoL-UK scores (p<0.05). Significant correlations were established between neuroticism and satisfaction with oral comfort, extraversion and total satisfaction and satisfaction with general performance, and openness and satisfaction with appearance (p<0.05). OHIP and OHQoL-UK scores had no significant correlations with psychological profiles. The status of the oral cavity can have a definitive impact on patients' daily living and quality of life regardless age, gender, and level of education. Patients' satisfaction with their dentition has definitive impacts on daily living, quality of life, and dental perceptions. Personality profiles (neuroticism; extraversion, and openness) may influence dental perceptions, play a significant role in shaping satisfaction with dentition, and help

  20. PRSice: Polygenic Risk Score software.

    Science.gov (United States)

    Euesden, Jack; Lewis, Cathryn M; O'Reilly, Paul F

    2015-05-01

    A polygenic risk score (PRS) is a sum of trait-associated alleles across many genetic loci, typically weighted by effect sizes estimated from a genome-wide association study. The application of PRS has grown in recent years as their utility for detecting shared genetic aetiology among traits has become appreciated; PRS can also be used to establish the presence of a genetic signal in underpowered studies, to infer the genetic architecture of a trait, for screening in clinical trials, and can act as a biomarker for a phenotype. Here we present the first dedicated PRS software, PRSice ('precise'), for calculating, applying, evaluating and plotting the results of PRS. PRSice can calculate PRS at a large number of thresholds ("high resolution") to provide the best-fit PRS, as well as provide results calculated at broad P-value thresholds, can thin Single Nucleotide Polymorphisms (SNPs) according to linkage disequilibrium and P-value or use all SNPs, handles genotyped and imputed data, can calculate and incorporate ancestry-informative variables, and can apply PRS across multiple traits in a single run. We exemplify the use of PRSice via application to data on schizophrenia, major depressive disorder and smoking, illustrate the importance of identifying the best-fit PRS and estimate a P-value significance threshold for high-resolution PRS studies. PRSice is written in R, including wrappers for bash data management scripts and PLINK-1.9 to minimize computational time. PRSice runs as a command-line program with a variety of user-options, and is freely available for download from http://PRSice.info jack.euesden@kcl.ac.uk or paul.oreilly@kcl.ac.uk Supplementary data are available at Bioinformatics online. © The Author 2014. Published by Oxford University Press.

  1. MPI Profiling

    Energy Technology Data Exchange (ETDEWEB)

    Han, D K; Jones, T R

    2005-02-11

    The Message Passing Interface (MPI) is the de facto message-passing standard for massively parallel programs. It is often the case that application performance is a crucial factor, especially for solving grand challenge problems. While there have been many studies on the scalability of applications, there have not been many focusing on the specific types of MPI calls being made and their impact on application performance. Using a profiling tool called mpiP, a large spectrum of parallel scientific applications were surveyed and their performance results analyzed.

  2. The Scoring of Writing Portfolios: Phase 2

    Science.gov (United States)

    White, Edward M.

    2005-01-01

    Although most portfolio evaluation currently uses some adaptation of holistic scoring, the problems with scoring portfolios holistically are many, much more than for essays, and the problems are not readily resolvable. Indeed, many aspects of holistic scoring work against the principles behind portfolio assessment. We have from the start needed a…

  3. Surgical Apgar Score predicts postoperative complications in ...

    African Journals Online (AJOL)

    Background: Predicting complications in neurotrauma patients by using an effective scoring system can reduce morbidity and mortality while facilitating objective clinical decision making during recovery. Compared to existing morbidity and mortality predictive scores, the Surgical Apgar Score (SAS) is simple and effective.

  4. An objective fluctuation score for Parkinson's disease.

    Directory of Open Access Journals (Sweden)

    Malcolm K Horne

    Full Text Available Establishing the presence and severity of fluctuations is important in managing Parkinson's Disease yet there is no reliable, objective means of doing this. In this study we have evaluated a Fluctuation Score derived from variations in dyskinesia and bradykinesia scores produced by an accelerometry based system.The Fluctuation Score was produced by summing the interquartile range of bradykinesia scores and dyskinesia scores produced every 2 minutes between 0900-1800 for at least 6 days by the accelerometry based system and expressing it as an algorithm.This Score could distinguish between fluctuating and non-fluctuating patients with high sensitivity and selectivity and was significant lower following activation of deep brain stimulators. The scores following deep brain stimulation lay in a band just above the score separating fluctuators from non-fluctuators, suggesting a range representing adequate motor control. When compared with control subjects the score of newly diagnosed patients show a loss of fluctuation with onset of PD. The score was calculated in subjects whose duration of disease was known and this showed that newly diagnosed patients soon develop higher scores which either fall under or within the range representing adequate motor control or instead go on to develop more severe fluctuations.The Fluctuation Score described here promises to be a useful tool for identifying patients whose fluctuations are progressing and may require therapeutic changes. It also shows promise as a useful research tool. Further studies are required to more accurately identify therapeutic targets and ranges.

  5. Combining Teacher Assessment Scores with External Examination ...

    African Journals Online (AJOL)

    This study investigated four statistical models for combining teacher assessment scores with external examination scores for certifying secondary school graduates in Ghana in terms of validity of the composite scores. The models studied were (1) external examination moderation with nominal weights, (2) reference school ...

  6. Credit Scores, Race, and Residential Sorting

    Science.gov (United States)

    Nelson, Ashlyn Aiko

    2010-01-01

    Credit scores have a profound impact on home purchasing power and mortgage pricing, yet little is known about how credit scores influence households' residential location decisions. This study estimates the effects of credit scores on residential sorting behavior using a novel mortgage industry data set combining household demographic, credit, and…

  7. Breaking of scored tablets : a review

    NARCIS (Netherlands)

    van Santen, E; Barends, D M; Frijlink, H W

    The literature was reviewed regarding advantages, problems and performance indicators of score lines. Scored tablets provide dose flexibility, ease of swallowing and may reduce the costs of medication. However, many patients are confronted with scored tablets that are broken unequally and with

  8. 15 CFR 285.15 - Obtaining documents.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Obtaining documents. 285.15 Section... VOLUNTARY LABORATORY ACCREDITATION PROGRAM § 285.15 Obtaining documents. (a) Application forms, NVLAP handbooks, and other NVLAP documents and information may be obtained by contacting the NVLAP, National...

  9. Association between sleep stages and hunger scores in 36 children.

    Science.gov (United States)

    Arun, R; Pina, P; Rubin, D; Erichsen, D

    2016-10-01

    Childhood obesity is a growing health challenge. Recent studies show that children with late bedtime and late awakening are more obese independent of total sleep time. In adolescents and adults, a delayed sleep phase has been associated with higher caloric intake. Furthermore, an adult study showed a positive correlation between REM sleep and energy balance. This relationship has not been demonstrated in children. However, it may be important as a delayed sleep phase would increase the proportion of REM sleep. This study investigated the relationship between hunger score and sleep physiology in a paediatric population. Thirty-six patients referred for a polysomnogram for suspected obstructive sleep apnoea were enrolled in the study. Sleep stages were recorded as part of the polysomnogram. Hunger scores were obtained using a visual analogue scale. Mean age was 9.6 ± 3.5 years. Mean hunger scores were 2.07 ± 2.78. Hunger scores were positively correlated with percentage of total rapid eye movement (REM) sleep (r = 0.438, P hunger score (r = -0.360, P hunger scores. These findings suggest that delayed bedtime, which increases the proportion of REM sleep and decreases the proportion of SWS, results in higher hunger levels in children. © 2015 World Obesity.

  10. Test-retest nasalance score variability in hypernasal speakers.

    Science.gov (United States)

    Watterson, Thomas; Lewis, Kerry E

    2006-07-01

    The objective of this study was to evaluate test-retest nasalance score variability in subjects with hypernasal resonance. Two groups of subjects with hypernasal speech recited both the Turtle Passage and the Mouse Passage two times each. For one group, the Nasometer headgear was not changed between repetitions of each stimulus (NCHG; n = 17); and for the other group, the headgear was changed between repetitions (CHG; n = 18). Three subjects in the CHG group would not recite the Mouse Passage two times. The subjects were 35 patients with hypernasal speech followed by a cleft palate team. The outcome measures were the four nasalance scores obtained for each subject. There was no significant difference between first and second repetitions for either stimulus in either the NCHG group or in the CHG group. Cumulative frequency tables showed that for the Turtle Passage-NCHG condition, 15 of the 17 (88%) repeated nasalance scores were within 5 nasalance points of each other. For the CHG condition, however, only 9 of 18 (50%) repeated nasalance scores were within 5 points. For the Mouse Passage-NCHG condition, 15 of the 17 (88%) repeated nasalance scores were within 5 points. For the CHG condition, however, only 11 of 15 (73%) repeated scores were within 5 points. Test-retest variability was greater in a population of hypernasal patients than that reported in other studies for normal speakers, and headgear change increased test-retest variability.

  11. Phenotyping of chronic obstructive pulmonary disease using the modified Bhalla scoring system for high-resolution computed tomography

    National Research Council Canada - National Science Library

    Tulek, Baykal; Kivrak, Ali Sami; Ozbek, Seda; Kanat, Fikret; Suerdem, Mecit

    2013-01-01

    .... To characterize the phenotypes of COPD according to high-resolution computed tomography (HRCT) findings; and to correlate HRCT scores obtained using the modified Bhalla scoring system with clinical and physiological indicators of systemic inflammation...

  12. Examining alternative scoring rubrics on a statewide test: The impact of different scoring methods on science and social studies performance assessments

    Science.gov (United States)

    Creighton, Susan Dabney

    There is no consensus regarding the most reliable and valid scoring methods for the assessment of higher order thinking skills. Most of the research on alternative formats has focused on the scoring of writing ability. This study examined the value of different types of performance assessment scoring guides on state mandated science and social studies tests. A proportional stratified sample of raters were randomly assigned to one of four scoring groups: checklist, analytic rubric, holistic rubric, and generic rubrics. A fifth method, the weighted analytic rubric, was included by applying an algorithmic formula to the scores assigned by raters using the analytic rubric. A comparison of the mean scores for the five scoring groups suggests that there may be a difference in the way raters applied the rubric for each group. Although the literature suggests that it is possible to achieve high levels of inter-rater reliability, across forms of scoring, phi coefficients of moderate strength were obtained for three of the four constructed-response items. Results for each scoring group were compared indicating that item complexity may impact the level of inter-rate, reliability and the selection of the most reliable rubric for each discipline. Analytic rubrics appear to achieve more reliable results with less complex items. A multitrait-multimethod approach was utilized to investigate the external validity of the social studies and science tasks. As expected, there tended to be a stronger association between the PACT science constructed-response scores with scores based on science multiple-choice scores than between the science constructed-response scores and the writing ability subtest scores. A similar pattern was seen with social studies items. These results provide some evidence for the validity of the performance assessments. A post study survey completed by raters provided qualitative information regarding their thought processes and their primary focus during the

  13. Amyotrophic Lateral Sclerosis Survival Score (ALS-SS): A simple scoring system for early prediction of patient survival.

    Science.gov (United States)

    Lunetta, Christian; Lizio, Andrea; Melazzini, Mario Giovanni; Maestri, Eleonora; Sansone, Valeria A

    2015-01-01

    Our objectives were: (1) to identify independent prognostic factors to determine a survival score for amyotrophic lateral sclerosis (ALS) in a cohort of patients followed in the NEMO Centre (NEuroMuscular Omnicentre); (2) to replicate results in an independent cohort obtained from the Pooled Resource Open Access ALS Clinical Trial Consortium (PRO-ACT) database. Samples were collected from 428 ALS patients from the NEMO database and 2481 patients from the PRO-ACT database. Study design was a retrospective analysis with clinical and biochemical variables, using univariable and multivariable Cox models of analysis. Results showed that, in multivariable analysis, age at diagnosis, diagnostic delay, ALSFRS-R total score, Body Mass Index, aspartate aminotransferase and creatinine level were independently related to survival. These factors were recoded as categorical variables assigning a score from 5 to 15, and the sums of these scores were used to obtain the ALS-Survival Score (ALS-SS). This then allowed to identify three groups having different survival curves. The ALS-SS results were also replicated using data from the PRO-ACT database. In conclusion, considering independent prognostic factors, we were able to give an estimate of survival in our cohort of ALS patients. Whether this ALS-SS may be useful in clinical practice, and potentially in clinical trials, will have to be determined prospectively.

  14. A PROFILE OF OLYMPIC TAEKWONDO COMPETITORS

    Directory of Open Access Journals (Sweden)

    Mohsen Kazemi

    2006-07-01

    Full Text Available The purpose of this study was to identify the profile of the Olympic champions and the other competitors who were involved in the Games. The information on each of the athletes was obtained from the "Official Site of the Sydney 2000 Olympic Games, www.olympics.com/eng/sports/TK" and included weight category, weight, height, age, points obtained, warnings, deduction point, defensive/offensive kicks and punches. One hundred and two athletes competed (54 males and 48 females in the Games. The mean average age and BMI (Body Mass Index of 16 male winners was 24.4 ± 3.3 years and 21.9 ± 2.4 respectively compared to 25.2 ± 4.3 years and 22.8 ± 3.3 for the 38 male non-winners. The mean average age and BMI of the 16 female winners was 23.1 ± 3.9 years and 20.8 ± 2.3 respectively compared to 24.9 ± 4.7 years and 21.3 ± 2.7 for the 32 female non-winners. For all four types of athletes, offensive kicks accounted for at least 52% of the techniques to score a point. Ninety-eight percent of all techniques used to score were kicks. Although not statistically significant, winners overall tended to be younger in age and taller with slightly lower BMI than their weight category average. Taking into account the literature cited in this article, future studies should be designed to examine the relationship between performance and functional variables such as muscle power, muscle endurance, reaction time and aerobic capacity.

  15. Are CT scans obtained at referring institutions justified prior to transfer to a pediatric trauma center?

    Science.gov (United States)

    Benedict, Leo Andrew; Paulus, Jessica K; Rideout, Leslie; Chwals, Walter J

    2014-01-01

    To assess whether pediatric trauma patients initially evaluated at referring institutions met Massachusetts statewide trauma field triage criteria for stabilization and immediate transfer to a Pediatric Trauma Center (PTC) without pre-transfer CT imaging. A 3-year retrospective cohort study was completed at our level 1 PTC. Patients with CT imaging at referring institutions were classified according to a triage scheme based on Massachusetts statewide trauma field triage criteria. Demographic data and injury profile characteristics were abstracted from patient medical records and our pediatric trauma registry. A total of 262 patients with 413 CT scans were reviewed from 2008 to 2011. 172 patients scanned (66%, 95% CI: 60%, 71%) met criteria for immediate transfer to a pediatric trauma center. Notably, 110 scans (27% of the total performed at referring institutions) were duplicated within four hours upon arrival to our PTC. GCS score transfer, and CT scan of the head was the most frequent scan obtained (53%). The majority of pediatric trauma patients were subjected to CT scans at referring institutions despite meeting Massachusetts trauma triage guidelines that call for stabilization and immediate transfer to a pediatric trauma center without any CT imaging. © 2014.

  16. Committee Opinion No. 644: The Apgar Score.

    Science.gov (United States)

    2015-10-01

    The Apgar score provides an accepted and convenient method for reporting the status of the newborn infant immediately after birth and the response to resuscitation if needed. The Apgar score alone cannot be considered to be evidence of or a consequence of asphyxia, does not predict individual neonatal mortality or neurologic outcome, and should not be used for that purpose. An Apgar score assigned during a resuscitation is not equivalent to a score assigned to a spontaneously breathing infant. The American Academy of Pediatrics and the American College of Obstetricians and Gynecologists encourage use of an expanded Apgar score reporting form that accounts for concurrent resuscitative interventions.

  17. Obtaining Diagnostic Classification Model Estimates Using Mplus

    Science.gov (United States)

    Templin, Jonathan; Hoffman, Lesa

    2013-01-01

    Diagnostic classification models (aka cognitive or skills diagnosis models) have shown great promise for evaluating mastery on a multidimensional profile of skills as assessed through examinee responses, but continued development and application of these models has been hindered by a lack of readily available software. In this article we…

  18. Nasalance scores for normal Korean-speaking adults and children.

    Science.gov (United States)

    Park, Mikyong; Baek, William S; Lee, Eunkyung; Koh, Kyung S; Kim, Baek-Kyu; Baek, Rongmin

    2014-02-01

    There are numerous nasometric studies to date, including normative nasalance scores for various languages as well as nasometric differences in age, gender, race and region except the Korean language. In this regard, we sought to establish normative nasalance scores for Koreans. We created speech samples based on the everyday use of phonemes in the Korean language which were syntactically simple for children. In addition, we analysed nasometric features based on age and gender and confirmed test-retest reliability. The study included 108 children (54 girls and 54 boys, aged 7-11 years) and 108 adults (54 women and 54 men, aged 18-29 years) with normal articulation, resonance, voice and hearing. Nasometer II 6400 was used to measure the nasalance scores. The subjects read or repeated three speech stimuli, each consisting of 33, 36 and 24 syllables: (1) an oral passage devoid of nasal consonants, (2) an oro-nasal passage and (3) nasal sentences. For each stimulus, mean nasalance scores were obtained and gender or age dependence was analysed, using two-way analyses of variance. The mean nasalance scores for the oral passage, oro-nasal passage and nasal sentences were 11.69% (standard deviation (SD) 3.68), 34.04% (SD 4.88) and 63.72% (SD 6.07), respectively. Female speakers exhibited significantly higher nasalance scores than male speakers on the oro-nasal passage (p = 0.000) and nasal sentences (p = 0.004). Children exhibited significantly higher nasalance scores than adults on nasal sentences (p = 0.000). The nasalance scores in children and females were a little higher. Korean normative data will provide reference information in the evaluation and treatment of resonance problems. Copyright © 2013 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.

  19. Importance of Wells score and Geneva score for the evaluation of patients suspected of pulmonary embolism.

    Science.gov (United States)

    Gruettner, Joachim; Walter, Thomas; Lang, Siegfried; Meyer, Michael; Apfaltrer, Paul; Henzler, Thomas; Viergutz, Tim

    2015-01-01

    The European Society of Cardiology guidelines for pulmonary embolism (PE) published in 2008 and updated in 2014 recommend a risk stratification including risk scores like Wells and the Geneva score. The utility and practicability of these scores are controversially discussed. Recently, in a trauma cohort and in spinal surgery patients, no correlation between Wells Score and PE diagnosis was found. The aim of the study was the evaluation of Wells and Geneva scores in patients presenting with chest pain, dyspnoea or syncope in an emergency department. We retrospectively examined 326 patients suspected of PE, including assessment, according to Wells and Geneva scores. PE was detected in 13.5 %. The average Wells score was 1.0, the average Geneva score 3.9. The receiver operating characteristic (ROC) curve analyses showed for both scores a high significant area under the curve (Wells score 0.68; Geneva score 0.64). The association between the scores and the diagnosis of PE was calculated with logistic regression analysis and showed high significant odds ratios (OR) for both scores (Wells score 1.38; Geneva score 1.24). There was no significant difference between the area under the curve (AUC) of Wells score and Geneva score. The utility of Wells and Geneva scores for the evaluation of patients suspected of PE in an emergency patient cohort. Copyright © 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

  20. Discrepancy between WISC-III and WISC-IV Cognitive Profile in Autism Spectrum: What Does It Reveal about Autistic Cognition?

    Science.gov (United States)

    Nader, Anne-Marie; Jelenic, Patricia; Soulières, Isabelle

    2015-01-01

    The cognitive profile and measured intellectual level vary according to assessment tools in children on the autism spectrum, much more so than in typically developing children. The recent inclusion of intellectual functioning in the diagnostic process for autism spectrum disorders leads to the crucial question on how to assess intelligence in autism, especially as some tests and subtests seem more sensitive to certain neurodevelopmental conditions. Our first aim was to examine the cognitive profile on the current version of the most widely used test, the Wechsler Intelligence Scales for Children (WISC-IV), for a homogenous subgroup of children on the autism spectrum, i.e. corresponding to DSM-IV diagnosis of “autism”. The second aim was to compare cognitive profiles obtained on the third edition versus 4th edition of WISC, in order to verify whether the WISC-IV yields a more distinctive cognitive profile in autistic children. The third aim was to examine the impact of the WISC-IV on the cognitive profile of another subgroup, children with Asperger’s Syndrome. 51 autistic, 15 Asperger and 42 typically developing children completed the WISC-IV and were individually matched to children who completed the WISC-III. Divergent WISC-IV profiles were observed despite no significant intelligence quotient difference between groups. Autistic children scored significantly higher on the Perceptual Reasoning Index than on the Verbal Comprehension Index, a discrepancy that nearly tripled in comparison to WISC-III results. Asperger children scored higher on the VCI than on other indexes, with the lowest score found on the Processing Speed Index. WISC-IV cognitive profiles were consistent with, but more pronounced than WISC-III profiles. Cognitive profiles are a valuable diagnostic tool for differential diagnosis, keeping in mind that children on the autism spectrum might be more sensitive to the choice of subtests used to assess intelligence. PMID:26673881

  1. Discrepancy between WISC-III and WISC-IV Cognitive Profile in Autism Spectrum: What Does It Reveal about Autistic Cognition?

    Science.gov (United States)

    Nader, Anne-Marie; Jelenic, Patricia; Soulières, Isabelle

    2015-01-01

    The cognitive profile and measured intellectual level vary according to assessment tools in children on the autism spectrum, much more so than in typically developing children. The recent inclusion of intellectual functioning in the diagnostic process for autism spectrum disorders leads to the crucial question on how to assess intelligence in autism, especially as some tests and subtests seem more sensitive to certain neurodevelopmental conditions. Our first aim was to examine the cognitive profile on the current version of the most widely used test, the Wechsler Intelligence Scales for Children (WISC-IV), for a homogenous subgroup of children on the autism spectrum, i.e. corresponding to DSM-IV diagnosis of "autism". The second aim was to compare cognitive profiles obtained on the third edition versus 4th edition of WISC, in order to verify whether the WISC-IV yields a more distinctive cognitive profile in autistic children. The third aim was to examine the impact of the WISC-IV on the cognitive profile of another subgroup, children with Asperger's Syndrome. 51 autistic, 15 Asperger and 42 typically developing children completed the WISC-IV and were individually matched to children who completed the WISC-III. Divergent WISC-IV profiles were observed despite no significant intelligence quotient difference between groups. Autistic children scored significantly higher on the Perceptual Reasoning Index than on the Verbal Comprehension Index, a discrepancy that nearly tripled in comparison to WISC-III results. Asperger children scored higher on the VCI than on other indexes, with the lowest score found on the Processing Speed Index. WISC-IV cognitive profiles were consistent with, but more pronounced than WISC-III profiles. Cognitive profiles are a valuable diagnostic tool for differential diagnosis, keeping in mind that children on the autism spectrum might be more sensitive to the choice of subtests used to assess intelligence.

  2. Discrepancy between WISC-III and WISC-IV Cognitive Profile in Autism Spectrum: What Does It Reveal about Autistic Cognition?

    Directory of Open Access Journals (Sweden)

    Anne-Marie Nader

    Full Text Available The cognitive profile and measured intellectual level vary according to assessment tools in children on the autism spectrum, much more so than in typically developing children. The recent inclusion of intellectual functioning in the diagnostic process for autism spectrum disorders leads to the crucial question on how to assess intelligence in autism, especially as some tests and subtests seem more sensitive to certain neurodevelopmental conditions. Our first aim was to examine the cognitive profile on the current version of the most widely used test, the Wechsler Intelligence Scales for Children (WISC-IV, for a homogenous subgroup of children on the autism spectrum, i.e. corresponding to DSM-IV diagnosis of "autism". The second aim was to compare cognitive profiles obtained on the third edition versus 4th edition of WISC, in order to verify whether the WISC-IV yields a more distinctive cognitive profile in autistic children. The third aim was to examine the impact of the WISC-IV on the cognitive profile of another subgroup, children with Asperger's Syndrome. 51 autistic, 15 Asperger and 42 typically developing children completed the WISC-IV and were individually matched to children who completed the WISC-III. Divergent WISC-IV profiles were observed despite no significant intelligence quotient difference between groups. Autistic children scored significantly higher on the Perceptual Reasoning Index than on the Verbal Comprehension Index, a discrepancy that nearly tripled in comparison to WISC-III results. Asperger children scored higher on the VCI than on other indexes, with the lowest score found on the Processing Speed Index. WISC-IV cognitive profiles were consistent with, but more pronounced than WISC-III profiles. Cognitive profiles are a valuable diagnostic tool for differential diagnosis, keeping in mind that children on the autism spectrum might be more sensitive to the choice of subtests used to assess intelligence.

  3. Latent profile analysis of students’ motivation and outcomes in mathematics: an organismic integration theory perspective

    Directory of Open Access Journals (Sweden)

    Chee Keng John Wang

    2017-05-01

    Full Text Available The purpose of the current study was to identify the motivation profiles at the intraindividual level using a latent profile analyses (LPA approach. A total of 1151 secondary school students aged 13 to 17 years old from Singapore took part in the study. Using LPA, four distinct motivational profiles were identified based on four motivation regulations. Profile 1 has very low introjected and low autonomous motivation (6% of sample. Profile 2 had high external and identified regulations and very low intrinsic regulation (10%. Profile 3 consisted of students with high identified and intrinsic regulations (51%. Profile 4 had moderately low identified and intrinsic regulations (33%. The results showed that the four profiles differed significantly in terms of effort, competence, value, and time spent on math beyond homework. The best profile (Profile 3 reported highest scores in effort, value, competence and time spent on Math beyond homework. The worst profile (Profile 1 reported lowest scores in all the four outcome variables.

  4. Individual Assessment of Arteriosclerosis by Empiric Clinical Profiling

    Science.gov (United States)

    Mutschelknauss, Marcus; Kummer, Marco; Muser, Juergen; Feinstein, Steve B.; Meyer, Peter M.; Biedermann, Barbara C.

    2007-01-01

    Background Arteriosclerosis is a common cause of chronic morbidity and mortality. Myocardial infarction, stroke or other cardiovascular events identify vulnerable patients who suffer from symptomatic arteriosclerosis. Biomarkers to identify vulnerable patients before cardiovascular events occur are warranted to improve care for affected individuals. We tested how accurately basic clinical data can describe and assess the activity of arteriosclerosis in the individual patient. Methodology/Principal Findings 269 in-patients who were treated for various conditions at the department of general medicine of an academic tertiary care center were included in a cross-sectional study. Personal history and clinical examination were obtained. When paraclinical tests were performed, the results were added to the dataset. The numerical variables in the clinical examination were statistically compared between patients with proven symptomatic arteriosclerosis (n = 100) and patients who had never experienced cardiovascular events in the past (n = 110). 25 variables were different between these two patient groups and contributed to the disease activity score. The percentile distribution of these variables defined the empiric clinical profile. Anthropometric data, signs of arterial, cardiac and renal disease, systemic inflammation and health economics formed the major categories of the empiric clinical profile that described an individual patient's disease activity. The area under the curve of the receiver operating curve for symptomatic arteriosclerosis was 0.891 (95% CI 0.799-0.983) for the novel disease activity score compared to 0.684 (95% CI 0.600-0.769) for the 10-year risk calculated according to the Framingham score. In patients suffering from symptomatic arteriosclerosis, the disease activity score deteriorated more rapidly after two years of follow-up (from 1.25 to 1.48, P = 0.005) compared to age- and sex-matched individuals free of cardiovascular events (from

  5. High Activity Arthroplasty Score has a lower ceiling effect than standard scores after knee arthroplasty.

    Science.gov (United States)

    Jenny, Jean-Yves; Louis, Pascal; Diesinger, Yann

    2014-04-01

    The tested hypothesis was following: the High Activity Arthroplasty Score has a significant lower ceiling effect than American Knee Society Score and Oxford Knee Score after total knee arthroplasty. One hundred patients operated on for total knee arthroplasty with more than one-year follow-up have been included. The ceiling effect was 53% for the American Knee Society Score, 33% for the Oxford Knee Score, and 0% for the High Activity Arthroplasty Score. High Activity Arthroplasty Score had a significantly lower ceiling effect than American Knee Society Score and Oxford Knee Score. High Activity Arthroplasty Score has the potential to detect more subtle differences in level of function than standard scoring systems among a non-selected total knee arthroplasty population. © 2014.

  6. Profile of newborns undergoing early stimulation in a neonatal intensive care unit

    Directory of Open Access Journals (Sweden)

    Karla Camila Lima de Souza

    2014-09-01

    Full Text Available Objective: To describe the profile of newborns undergoing early stimulation in a neonatal intensive care unit, characterizing the study population according to their neonatal variables and risk factors indicative for the early stimulation treatment. Methods: Cross-sectional and analytical study, held in a reference hospital of Fortaleza, in the period from February to March 2011, with sample consisting of 116 medical records of newborns indicated for the early stimulation treatment. The following variables were analyzed: weight, sex, gestational age, Apgar score, diagnosis of Respiratory Distress Syndrome and Intracranial Hemorrhage, use of mechanical ventilation and continuous positive airway pressure (CPAP. The variables were analyzed using Microsoft Excel™ 2007 software to obtain mean and mode. Results: Among the studied variables, there was a prevalence of low birth weight, prematurity and male newborns. According to the Apgar score, scores of 1st and 5th minutes showed increasing values. Regarding the studied pathologies, the Respiratory Distress Syndrome stands out as the most prevalent, followed by Intracranial Hemorrhage. Concerning the use of mechanical ventilation, CPAP was the most frequently indicated modality, followed by mechanical ventilation. Conclusion: The profile of newborns investigated in this study, which underwent early stimulation in a neonatal intensive care, is represented by male, premature, low weight and high rate of Apgar score at 1st and 5th minutes, with prevalence of respiratory distressand increased use of CPAP. doi:http://dx.doi.org/10.5020/18061230.2013.p523

  7. Scoring functions and enrichment: a case study on Hsp90

    Directory of Open Access Journals (Sweden)

    Mitchell John BO

    2007-01-01

    Full Text Available Abstract Background The need for fast and accurate scoring functions has been driven by the increased use of in silico virtual screening twinned with high-throughput screening as a method to rapidly identify potential candidates in the early stages of drug development. We examine the ability of some the most common scoring functions (GOLD, ChemScore, DOCK, PMF, BLEEP and Consensus to discriminate correctly and efficiently between active and non-active compounds among a library of ~3,600 diverse decoy compounds in a virtual screening experiment against heat shock protein 90 (Hsp90. Results Firstly, we investigated two ranking methodologies, GOLDrank and BestScorerank. GOLDrank is based on ranks generated using GOLD. The various scoring functions, GOLD, ChemScore, DOCK, PMF, BLEEP and Consensus, are applied to the pose ranked number one by GOLD for that ligand. BestScorerank uses multiple poses for each ligand and independently chooses the best ranked pose of the ligand according to each different scoring function. Secondly, we considered the effect of introducing the Thr184 hydrogen bond tether to guide the docking process towards a particular solution, and its effect on enrichment. Thirdly, we considered normalisation to account for the known bias of scoring functions to select larger molecules. All the scoring functions gave fairly similar enrichments, with the exception of PMF which was consistently the poorest performer. In most cases, GOLD was marginally the best performing individual function; the Consensus score usually performed similarly to the best single scoring function. Our best results were obtained using the Thr184 tether in combination with the BestScorerank protocol and normalisation for molecular weight. For that particular combination, DOCK was the best individual function; DOCK recovered 90% of the actives in the top 10% of the ranked list; Consensus similarly recovered 89% of the actives in its top 10%. Conclusion Overall, we

  8. Essays on probability elicitation scoring rules

    Science.gov (United States)

    Firmino, Paulo Renato A.; dos Santos Neto, Ademir B.

    2012-10-01

    In probability elicitation exercises it has been usual to considerer scoring rules (SRs) to measure the performance of experts when inferring about a given unknown, Θ, for which the true value, θ*, is (or will shortly be) known to the experimenter. Mathematically, SRs quantify the discrepancy between f(θ) (the distribution reflecting the expert's uncertainty about Θ) and d(θ), a zero-one indicator function of the observation θ*. Thus, a remarkable characteristic of SRs is to contrast expert's beliefs with the observation θ*. The present work aims at extending SRs concepts and formulas for the cases where Θ is aleatory, highlighting advantages of goodness-of-fit and entropy-like measures. Conceptually, it is argued that besides of evaluating the personal performance of the expert, SRs may also play a role when comparing the elicitation processes adopted to obtain f(θ). Mathematically, it is proposed to replace d(θ) by g(θ), the distribution that model the randomness of Θ, and do also considerer goodness-of-fit and entropylike metrics, leading to SRs that measure the adherence of f(θ) to g(θ). The implications of this alternative perspective are discussed and illustrated by means of case studies based on the simulation of controlled experiments. The usefulness of the proposed approach for evaluating the performance of experts and elicitation processes is investigated.

  9. Comparative studies on pectinases obtained from Aspergillus ...

    African Journals Online (AJOL)

    Comparative studies on pectinases obtained from Aspergillus fumigatus and Aspergillus niger in submerged fermentation system using pectin extracted from mango, orange and pineapple peels as carbon sources.

  10. Splitting the BLOSUM Score into Numbers of Biological Significance

    Directory of Open Access Journals (Sweden)

    Tossi Alessandro

    2007-01-01

    Full Text Available Mathematical tools developed in the context of Shannon information theory were used to analyze the meaning of the BLOSUM score, which was split into three components termed as the BLOSUM spectrum (or BLOSpectrum. These relate respectively to the sequence convergence (the stochastic similarity of the two protein sequences, to the background frequency divergence (typicality of the amino acid probability distribution in each sequence, and to the target frequency divergence (compliance of the amino acid variations between the two sequences to the protein model implicit in the BLOCKS database. This treatment sharpens the protein sequence comparison, providing a rationale for the biological significance of the obtained score, and helps to identify weakly related sequences. Moreover, the BLOSpectrum can guide the choice of the most appropriate scoring matrix, tailoring it to the evolutionary divergence associated with the two sequences, or indicate if a compositionally adjusted matrix could perform better.

  11. Forecasting the value of credit scoring

    Science.gov (United States)

    Saad, Shakila; Ahmad, Noryati; Jaffar, Maheran Mohd

    2017-08-01

    Nowadays, credit scoring system plays an important role in banking sector. This process is important in assessing the creditworthiness of customers requesting credit from banks or other financial institutions. Usually, the credit scoring is used when customers send the application for credit facilities. Based on the score from credit scoring, bank will be able to segregate the "good" clients from "bad" clients. However, in most cases the score is useful at that specific time only and cannot be used to forecast the credit worthiness of the same applicant after that. Hence, bank will not know if "good" clients will always be good all the time or "bad" clients may become "good" clients after certain time. To fill up the gap, this study proposes an equation to forecast the credit scoring of the potential borrowers at a certain time by using the historical score related to the assumption. The Mean Absolute Percentage Error (MAPE) is used to measure the accuracy of the forecast scoring. Result shows the forecast scoring is highly accurate as compared to actual credit scoring.

  12. A new high-flexion knee scoring system to eliminate the ceiling effect.

    Science.gov (United States)

    Na, Sang-Eun; Ha, Chul-Won; Lee, Choong-Hee

    2012-02-01

    Various scoring systems document improvement after TKA, but most are associated with a ceiling effect that may fail to distinguish between patients having different levels of knee function after TKA. We therefore developed a new scoring system for patients with higher levels of flexion to eliminate ceiling effects observed with current systems. The purposes of this study were (1) to determine whether the high-flexion knee score eliminates the ceiling effect, (2) to assess the validity and responsiveness of the high-flexion knee score, and (3) to determine whether the high-flexion knee score can aid in differentiation of the knee status of patients at the ceiling level. We prospectively studied 165 patients with 201 well-functioning knees who had undergone primary TKA. We obtained Knee Society scores, WOMAC scores, Feller scores, SF-36 scores, and high-flexion knee scores for all patients. The high-flexion knee score includes items that reflect knee function in the high functional range, such as sitting on or rising from the floor, squatting, or kneeling. We determined the ceiling effects and score distributions of various scoring systems. We performed a convergent validity test of the high-flexion knee score by correlation analysis with these various scoring systems. Responsiveness of the high-flexion knee score was assessed by correlation analysis of changes in various scoring systems. To determine whether the high-flexion knee score can aid in differentiation of knee status of patients at the ceiling level, relative responsiveness of the various scores in the ceiling versus below the ceiling range was determined. The high-flexion knee score showed no ceiling effect, whereas the other systems did. Addition of the high-flexion knee score to the other scoring systems eliminated these ceiling effects and resulted in more normalized score distributions. The high-flexion knee score correlated (r = -0.77) with WOMAC in postoperative scores, and it also correlated with

  13. A Score Function for Optimizing the Cycle-Life of Battery-Powered Embedded Systems

    DEFF Research Database (Denmark)

    Wognsen, Erik Ramsgaard; Haverkort, Boudewijn; Jongerden, Marijn

    2015-01-01

    An ever increasing share of embedded systems is powered by rechargeable batteries. These batteries deteriorate with the number of charge/discharge cycles they are subjected to, the so-called cycle life. In this paper, we propose the wear score function to compare and evaluate the relative impact...... of usage (charge and discharge) profiles on cycle life. The wear score function can not only be used to rank different usage profiles, these rankings can also be used as a criterion for optimizing the overall lifetime of a battery-powered system. We perform such an optimization on a nano-satellite case...

  14. Astrophysical Reaction Rates Obtained By Indirect Techniques

    Science.gov (United States)

    Tribble, R. E.; Al-Abdullah, T.; Alharbi, A.; Äystö, J.; Banu, A.; Burjan, V.; Carstoiu, F.; Chen, X.; Clark, H. L.; Davidson, T.; Fu, C.; Gagliardi, C. A.; Hardy, J. C.; Iacob, V. E.; Jokinen, J.; Kroha, V.; Lui, Y.-W.; McCleskey, M.; Mukhamedzhanov, A.; Nica, N.; Park, H. I.; Roeder, B.; Saastamoinen, A.; Simmons, E.; Tabacaru, G.; Tokimoto, Y.; Trache, L.; Woods, P. J.; Zhai, Y.

    2010-08-01

    Indirect techniques have been used to obtain information about reaction rates for several proton capture reactions that occur on short-lived nuclei. The techniques used to carry out the measurements are reviewed and the results obtained are presented. Also future prospects for further measurements with a new facility, T-REX are discussed.

  15. Random Walk Picture of Basketball Scoring

    CERN Document Server

    Gabel, Alan

    2011-01-01

    We present evidence, based on play-by-play data from all 6087 games from the 2006/07--2009/10 seasons of the National Basketball Association (NBA), that basketball scoring is well described by a weakly-biased continuous-time random walk. The time between successive scoring events follows an exponential distribution, with little memory between different scoring intervals. Using this random-walk picture that is augmented by features idiosyncratic to basketball, we account for a wide variety of statistical properties of scoring, such as the distribution of the score difference between opponents and the fraction of game time that one team is in the lead. By further including the heterogeneity of team strengths, we build a computational model that accounts for essentially all statistical features of game scoring data and season win/loss records of each team.

  16. Standardization of nasalance scores in normal Saudi speakers.

    Science.gov (United States)

    El-Kassabi, Rasha M; Hassan, Sabah; Mesallam, Tamer A; Malki, Khalid H; Farahat, Mohamed; Alfaris, Abdullah

    2015-07-01

    The aims of this study were to obtain normative nasalance scores for a normal Saudi population with different ages and genders, to develop nasometric Arabic speech materials, and to make cross-linguistic comparison. Participants included 219 normal Saudi native monolingual Arabic speakers of different ages. Subjects were classified into four groups according to age and gender. Subjects did not have any history of oral, nasal, or velopharyngeal abnormality. Arabic speech samples were developed to evaluate nasalance scores, which included syllables repetition, three oral sentences, three oro-nasal sentences, and three nasal sentences. Nasalance data were obtained using Nasometer II-6400. Normative nasalance values were determined. Significant differences between the male and female children groups were noticed in many parameters. Nasalance scores were higher in adults, with significant differences between all groups. Normative nasalance scores for Saudi Arabic speakers have been developed for both adults and children. The Arabic speech materials developed in this study appear to be easy to use and applicable for different age groups.

  17. Facial profile esthetic preferences: perception in two Brazilian states

    Directory of Open Access Journals (Sweden)

    Marina Detoni Vieira de Oliveira

    2015-06-01

    Full Text Available OBJECTIVE: The aim of this study was to assess the regional influence on the perception of facial profile esthetics in Rio de Janeiro state (RJ and Rio Grande do Sul state (RS, Brazil. METHODS: Two Caucasian models, a man and a woman, with balanced facial profiles, had their photographs digitally manipulated so as to produce seven different profiles. First year dental students (laypeople assessed the images and classified them according to their esthetic preference. RESULTS: The result of the t test for independent samples showed differences among states for certain facial profiles. The female photograph identified with the letter 'G' (mandibular retrusion received higher scores in RS state (p = 0.006. No differences were found for male photographs (p > 0.007. The evaluators' sex seemed not to influence their esthetic perception (p > 0.007. Considering all evaluators together, ANOVA/Tukey's test showed differences among the profiles (p ≤ 0.05 for both male and female photographs. The female photograph that received the highest score was the one identified with the letter 'F' (dentoalveolar bimaxillary retrusion/ straight profile. For the male profiles, photograph identified with the letter 'E' (dentoalveolar bimaxillary protrusion/ straight profile received the best score. CONCLUSION: Regional differences were observed regarding preferences of facial profile esthetics. In Rio de Janeiro state, more prominent lips were preferred while in Rio Grande do Sul state, profiles with straight lips were favored. Class III profiles were considered less attractive.

  18. Personalized video summarization based on group scoring

    OpenAIRE

    Darabi, K; G. Ghinea

    2014-01-01

    In this paper an expert-based model for generation of personalized video summaries is suggested. The video frames are initially scored and annotated by multiple video experts. Thereafter, the scores for the video segments that have been assigned the higher priorities by end users will be upgraded. Considering the required summary length, the highest scored video frames will be inserted into a personalized final summary. For evaluation purposes, the video summaries generated by our system have...

  19. Deriving utility scores from the SF-36 health instrument using Rasch analysis.

    Science.gov (United States)

    Hawthorne, Graeme; Densley, Konstancja; Pallant, Julie F; Mortimer, Duncan; Segal, Leonie

    2008-11-01

    Utility scores for use in cost-utility analysis may be imputed from the SF-36 health instrument using various techniques, typically regression analysis. This paper explored imputation using partial credit Rasch analysis. Data from the Assessment of Quality of Life (AQoL) instrument validation study were re-analysed (n = 996 inpatients, outpatients and a community sample). For each AQoL item, factor analysis identified those SF-36 items forming a unidimensional scale. Rasch analysis located scale logit scores for these SF-36 items. The logit scores were used to assign AQoL item scores. The standard AQoL scoring algorithm was then applied to obtain the utility scores. Many SF-36 items were limited predictors of AQoL items; some items from both instruments obtained disordered thresholds. All imputed scores were consistent with the AQoL model and fell within AQoL score boundaries. The explained variance between imputed and true AQoL scores was 61%. Rasch-imputed mapping, unlike many regression-based algorithms, produced results consistent with the axioms of utility measurement, while the proportion of explained variance was similar to regression-based modelling. Item properties on both instruments implied that some items should be revised using Rasch analysis. The methods and results may be used by researchers needing to impute utility scores from SF-36 health scores.

  20. Online risk engines and scoring tools in endocrinology

    Directory of Open Access Journals (Sweden)

    Partha Pratim Chakraborty

    2013-01-01

    Full Text Available With evolution of evidence-based medicine, risk prediction equations have been formulated and validated. Such risk engines and scoring systems are able to predict disease outcome and risks of possible complications with varying degrees of accuracy. From health policy makers point of view it helps in appropriate disbursement of available resources for greatest benefit of population at risk. Understandably, the accuracy of prediction of different risk engines and scoring systems are highly variable and has several limitations. Each risk engine or clinical scoring tool is derived from data obtained from a particular population and its results are not generalizable and hence its ability to predict risk/outcome in a different population with differences in ethnicity, ages, and differences in distribution of risk factors over time both within and between populations. These scoring systems and risk engines to begin with were available for manual calculations and references/use of formula and paper charts were essential. However, with evolution of information technology such calculations became easier to make with use of online web-based tools. In recent times with advancement of android technology, easy to download apps (applications has helped further to have the benefits of these online risk engines and scoring systems at our finger tips.

  1. TIMI Risk Score predicts early readmission.

    Science.gov (United States)

    Soiza, Roy L; Hughes, Niall J; Leslie, Stephen J; Peden, Norman R; Hargreaves, Allister D

    2006-08-10

    To assess if the TIMI Risk Score could predict early readmission. 869 consecutive admissions to a Scottish district general hospital with suspected acute coronary syndrome. A computerised clinical information system was interrogated to verify readmission. Area under the receiver operator characteristic curve and chi-square test for trend between TIMI Risk Score and readmission rate were calculated. Median follow up was 73 days. There was a strong association between TIMI Risk Score and readmission rate (chi-square test for trend, pTIMI Risk Score can predict readmission. This study reinforces its utility as a tool for identifying patients more likely to benefit from aggressive intervention.

  2. The FAt Spondyloarthritis Spine Score (FASSS)

    DEFF Research Database (Denmark)

    Pedersen, Susanne Juhl; Zhao, Zheng; Lambert, Robert Gw

    2013-01-01

    Studies have shown that fat lesions follow resolution of inflammation in the spine of patients with axial spondyloarthritis (SpA). Fat lesions at vertebral corners have also been shown to predict development of new syndesmophytes. Therefore, scoring of fat lesions in the spine may constitute both...... an important measure of treatment efficacy as well as a surrogate marker for new bone formation. The aim of this study was to develop and validate a new scoring method for fat lesions in the spine, the Fat SpA Spine Score (FASSS), which in contrast to the existing scoring method addresses the localization...

  3. Coronary artery calcium score: current status

    Science.gov (United States)

    Neves, Priscilla Ornellas; Andrade, Joalbo; Monção, Henry

    2017-01-01

    The coronary artery calcium score plays an Important role In cardiovascular risk stratification, showing a significant association with the medium- or long-term occurrence of major cardiovascular events. Here, we discuss the following: protocols for the acquisition and quantification of the coronary artery calcium score by multidetector computed tomography; the role of the coronary artery calcium score in coronary risk stratification and its comparison with other clinical scores; its indications, interpretation, and prognosis in asymptomatic patients; and its use in patients who are symptomatic or have diabetes. PMID:28670030

  4. Utility of SOFA and APACHE II score in sepsis in rural set up MICU.

    Science.gov (United States)

    Desai, Samir; Lakhani, J D

    2013-09-01

    To assess morbidity and mortality as well as to prognosticate the patients by using SOFA and APACHE II scores of patients with sepsis, severe sepsis and multi-organ dysfunction syndrome (MODS) in rural setup ICU. We carried out prospective study on patients with sepsis as per ACCP guidelines and analysed their clinical and microbiological profile. We calculated SOFA score on day 1, 3 and 7. APACHE II score was also calculated on day of admission. We used both the scores for predicting the outcome. The mortality rate was 48% in our study group which had alarming proportion of MODS patients (78%). The most common organ involved was lung and the most common organism causing sepsis was Klebseilla. On day 3, the mortality rate of patients with SOFA score less than nine was 9.1%, while the mortality rate of patients with score more than nine was 78%. The trend of mean SOFA score was progressively declining in survivor group. The mean APACHE II score was marginally higher in non-survivor group compared to survivor group, however the difference was not statistically significant. Serial measurement of SOFA score during first week is very useful tool in predicting the outcome. The APACHE II score on day of admission was not reliable in predicting the mortality rate in this study and we believe that it may need modification in set up like ours.

  5. Accuracy and Latency Scores as Measures of Spatial Information Processing.

    Science.gov (United States)

    1976-02-27

    NA04E AND ADDRESS Ja ufflao- ATI& Naval Medical Research Development Command 2 adI1117 National Naval Medical Center 30U O AG , 4_’%ESS(1e differentt...20 (Continued)iv experiments four nevi spatial tests we-e administered to groups of U. S. Navy pilot and Flight Officer Candidates. The psychomotric ...of any measure should be examined. 3. Obtain intercorrelations of scores. The pattern of correlations most desirable for the purpose of developing new

  6. Treatment of biomass to obtain ethanol

    Science.gov (United States)

    Dunson, Jr., James B.; Elander, Richard T [Evergreen, CO; Tucker, III, Melvin P.; Hennessey, Susan Marie [Avondale, PA

    2011-08-16

    Ethanol was produced using biocatalysts that are able to ferment sugars derived from treated biomass. Sugars were obtained by pretreating biomass under conditions of high solids and low ammonia concentration, followed by saccharification.

  7. 47 CFR 54.615 - Obtaining services.

    Science.gov (United States)

    2010-10-01

    ... non-profit entity that falls within one of the seven categories set forth in the definition of health... provided under § 54.621, that the requester cannot obtain toll-free access to an Internet service provider...

  8. Mass culture of photobacteria to obtain luciferase

    Science.gov (United States)

    Chappelle, E. W.; Picciolo, G. L.; Rich, E., Jr.

    1969-01-01

    Inoculating preheated trays containing nutrient agar with photobacteria provides a means for mass culture of aerobic microorganisms in order to obtain large quantities of luciferase. To determine optimum harvest time, growth can be monitored by automated light-detection instrumentation.

  9. Are Raw Scores on Memory Tests Better than Age- and Education- Adjusted Scores for Predicting Progression from Amnesic Mild Cognitive Impairment to Alzheimer Disease ?

    Science.gov (United States)

    Quaranta, Davide; Gainotti, Guido; Vita, Maria Gabriella; Lacidogna, Giordano; Scaricamazza, Eugenia; Piccininni, Chiara; Marra, Camillo

    2016-01-01

    In this prospective longitudinal study, conducted in a large sample of amnestic MCI patients over a three-year period, we investigated the recently advanced proposal that unadjusted test scores obtained at baseline on long-term memory tests are more reliable than age- and education-corrected scores in predicting progression from aMCI to AD. Our experimental sample consisted of 270 aMCI patients who underwent extensive neurological and neuropsychological examinations both at baseline and at the follow-up, conducted at least 3 years later. At the follow-up 80 patients had converted to overt dementia. The predictive capacity of raw, age-corrected, education-corrected and fully corrected scores on RAVLT immediate and delayed recall was compared by examining the area under the ROC curves (AUCs) of all of these scores to assess which (raw or corrected) scores achieves the better reliability in predicting conversion to dementia. The condition (aMCI stable vs converted) was analyzed to assess the odds ratios resulting from a logistic regression on the corrected and uncorrected scores of RAVLT immediate and delayed recall. Even if both in immediate and in delayed recall the ROCs of 'raw scores' were generally higher than the other ROCs on corrected scores, these differences did not reach the level of statistical significance, failing to support the claim that unadjusted test scores are superior to age- and education-corrected scores in predicting progression from aMCI to AD.

  10. Discrepancy Between Clinician and Research Assistant in TIMI Score Calculation (TRIAGED CPU)

    OpenAIRE

    Taylor, Brian T.; Mancini, Michelino

    2014-01-01

    Introduction: Several studies have attempted to demonstrate that the Thrombolysis in Myocardial Infarction (TIMI) risk score has the ability to risk stratify emergency department (ED) patients with potential acute coronary syndromes (ACS). Most of the studies we reviewed relied on trained research investigators to determine TIMI risk scores rather than ED providers functioning in their normal work capacity. We assessed whether TIMI risk scores obtained by ED providers in the setting of a busy...

  11. Semiparametric Copula Models for Biometric Score Level

    NARCIS (Netherlands)

    Caselli, M.

    2016-01-01

    In biometric recognition systems, biometric samples (images of faces, finger- prints, voices, gaits, etc.) of people are compared and classifiers (matchers) indicate the level of similarity between any pair of samples by a score. If two samples of the same person are compared, a genuine score is

  12. What do educational test scores really measure?

    DEFF Research Database (Denmark)

    McIntosh, James; D. Munk, Martin

    measure of pure cognitive ability. We find that variables which are not closely associated with traditional notions of intelligence explain a significant proportion of the variation in test scores. This adds to the complexity of interpreting test scores and suggests that school culture, attitudes......, and possible incentive problems make it more difficult to elicit true values of what the tests measure....

  13. Comparability of IQ scores over time

    NARCIS (Netherlands)

    Must, O.; te Nijenhuis, J.; Must, A.; van Vianen, A.E.M.

    2009-01-01

    This study investigates the comparability of IQ scores. Three cohorts (1933/36, 1997/98, 2006) of Estonian students (N = 2173) are compared using the Estonian National Intelligence Test. After 72 years the secular rise of the IQ test scores is.79 SD. The mean .16 SD increase in the last 8 years

  14. Observed Score Linear Equating with Covariates

    Science.gov (United States)

    Branberg, Kenny; Wiberg, Marie

    2011-01-01

    This paper examined observed score linear equating in two different data collection designs, the equivalent groups design and the nonequivalent groups design, when information from covariates (i.e., background variables correlated with the test scores) was included. The main purpose of the study was to examine the effect (i.e., bias, variance, and…

  15. Quality scores for 32,000 genomes

    DEFF Research Database (Denmark)

    Land, Miriam L.; Hyatt, Doug; Jun, Se-Ran

    2014-01-01

    public databases, and assigned quality scores for more than 30,000 prokaryotic genome sequences. Results Scores were assigned using four categories: the completeness of the assembly, the presence of full-length rRNA genes, tRNA composition and the presence of a set of 102 conserved genes in prokaryotes...

  16. The AASM scoring manual: a critical appraisal.

    Science.gov (United States)

    Grigg-Damberger, Madeleine M

    2009-11-01

    Summarize recently published studies and critiques evaluating the effects of the American Academy of Sleep Medicine (AASM) Sleep Scoring Manual. Only a few retrospective studies have been published evaluating the new AASM Scoring Manual. These have shown that when scoring polysomnograms (PSGs) using the AASM rules compared to previous standards and guidelines: increased amount and percentage of sleep time in Non-Rapid Eye Movement Sleep (NREM) 1 (N1) and N3 sleep, and decreased NREM 2 (N2) sleep; improved interscorer reliability when scoring sleep stages in adults; large differences in apnea-hypopnea indexes (AHIs) using different hypopnea scoring definitions; and PSGs scored using the 'recommended' hypopnea definition in the new manual identified no significant sleep disordered breathing in 40% of lean individuals with symptomatic OSA (AHI ≥5/h by 1999 'Chicago' criteria) and a favorable response to treatment. Two years have passed since the AASM Scoring Manual was published, garnering less criticism than was feared by those who developed it. The improvement in interscorer reliability using the Manual is heartening since this goal shaped many of the choices made. The alternative hypopnea rule should be endorsed as a recommended option. The AASM Scoring Manual provides a foundation upon which we all can build rules and methods that quantify the complexity of sleep and its disorders. Multicenter validation and refinement of the Manual is encouraged.

  17. Surgical Apgar Score Predicts Post- Laparatomy Complications ...

    African Journals Online (AJOL)

    Introduction: The Surgical Apgar score (SAS) presents a simple, immediate and an objective means of determining surgical outcomes. The score has not been widely validated in low resource settings where it would be most valuable. This study aimed to evaluate its accuracy and applicability for patients undergoing ...

  18. On k-hypertournament losing scores

    CERN Document Server

    Pirzada, Shariefuddin

    2010-01-01

    We give a new and short proof of a theorem on k-hypertournament losing scores due to Zhou et al. [G. Zhou, T. Yao, K. Zhang, On score sequences of k-tournaments, European J. Comb., 21, 8 (2000) 993-1000.

  19. Attractiveness of facial profiles as rated by individuals with different levels of education.

    Science.gov (United States)

    Hönn, Mirjam; Dietz, Klaus; Eiselt, Marie-Luise; Göz, Gernot

    2008-01-01

    The reasons people consult the orthodontist are functional, prophylactic and esthetic in nature, which is why it is important to know (in justifying an intervention for esthetic reasons) what patients themselves find attractive, and whether German university graduates and non-graduates would evaluate the attractiveness of profile views of Class-I, -II and -III patients differently. We also were interested in identifying per group the degree of deviation (from a "normal" skeletal profile) from which the appraisers would judge that profile to be unattractive. A total of five skeletal Class-I patients with straight-average faces (ideal biometric face as defined by A. M. Schwarz 1958) were transformed to reflect three Class-II profile variants and three Class-III profile variants with Onyx Ceph software. Out of the 35 profiles thus obtained we formed two groups of 20 each. Group 1 comprised the five straight-average (biometric) faces and six retrognathic and nine prognathic profile variants. Group 2 comprised the same five straight-average faces and the remaining retrognathic and prognathic profile variants. Both face groups were evaluated by 117 university graduates (65 men and 52 women) and 103 non-graduates (49 men and 54 women) between 23 and 41 years old. The participants were randomly assigned to the two groups. These volunteers were asked to rate the profiles along a scale of 0 (least attractive) to 10 (most attractive). The paper copies with the profiles were assessed in comparison to a single profile that had been classified with an average of 7.6 by ten orthodontists. Both groups of observers perceived the five straight-average faces similarly in the first and second scoring rounds. The straight-average face was perceived as the most attractive by both the university graduates (mean: 5.37; 95% CI: 5.15-5.59) and non-graduates (mean: 5.71; 95% CI: 5.48-5.95), followed immediately by mildly and moderately retrognathic, as well as mildly prognathic profile lines

  20. A COMPARISON OF CYTOKINE MESSAGE AND PROTEIN PROFILES OBTAINED FOLLOWING DERMAL EXPOSURE TO DIISOCYANATES.

    Science.gov (United States)

    Exposure to certain low molecular weight chemicals is associated with asthma. A simple method to identify this hazard is needed. Increased expression of Th2 cytokine mRNA in draining lymph nodes following dermal exposure and increased production of Th2 cytokines by cultured cell...

  1. The profile of Brazilian agriculture as source of raw material to obtain organic cosmetics

    Directory of Open Access Journals (Sweden)

    Neila de Paula Pereira

    2017-05-01

    Full Text Available With one of the most notable floras in the world for sustainable research, the Brazilian Amazon region currently counts on financial incentives from the Brazilian Government for private national and foreign businesses. The ongoing implantation of a Biocosmetics Research and Development Network (REDEBIO aims to stimulate research involving natural resources from the Brazilian states that make up the zone defined as “Amazônia Legal”. The objective of this region, still under development in Brazil, is principally to aggregate value to products manufactured in small local industries through the use of sustainable technology currently being established. Certain certified raw materials already included in the country’s sustainability program, have also begun to be cultivated according to the requirements of organic cultivation (Neves, 2009. The majority are species of Amazonian vegetation: Euterpe oleracea (Açai, Orbignya martiana (Babaçu, Theobroma grandi-florum (Cupuaçu, Carapas guianensis (Andiroba, Pentaclethra macroloba (Pracaxi, Copaifera landesdorffi (Copaiba, Platonia insignis (Bacuri, Theobroma cacao (Cacao, Virola surinamensis (Ucuuba and Bertholletia excelsa (Brazil nut. These generate phytopreparations, such as oils, extracts, and dyes that are widely used in the manufacture of Brazilian organic cosmetics with scientifically proven topical and capillary benefits. In the final balance, Brazilian organic cosmetics should continue to gain force over the next few years, especially with the regulation of the organic cosmetics market that is being drafted by the Brazilian Ministry of Agriculture. Moreover, lines of ecologically aware products that provide quality of life for both for rural and metropolitan communities show a tendency to occupy greater space in the market.

  2. The genetic profiles of two salmonid populations from Romania obtained through nuclear markers analysis

    Directory of Open Access Journals (Sweden)

    Ramona Nechifor

    2017-05-01

    Full Text Available The Salmonidae fish family is well represented in Romanian fauna, with a total of six species in the wild and reared in fish farms. Among them, the brown trout (Salmo trutta fario can be found in all major Romanian river basins. However, anthropogenic activities might disrupt salmonids’ habitats, so that inbreeding and genetic isolation might easily occur in the wild populations. We analyzed two wild brown trout populations from rivers targeted by anthropogenic activities, by using nuclear markers and genotyping in order to observe their genetic structure. We analyzed nine microsatellites and we observed their alleles frequencies, number of private alleles, observed and expected heterozygosity, as well as their population structure. The two populations are not in Hardy-Weinberg equilibrium for most of the loci and the inbreeding coefficient for both populations suggests a heterozygote deficit. Further sequencing data are needed in order to have a better view upon their complete genetic structure.

  3. Polycrystalline silicon carbide dopant profiles obtained through a scanning nano-Schottky contact

    Energy Technology Data Exchange (ETDEWEB)

    Golt, M. C.; Strawhecker, K. E.; Bratcher, M. S. [U.S. Army Research Laboratory, WMRD, Aberdeen Proving Ground, Maryland 21005 (United States); Shanholtz, E. R. [ORISE, Belcamp, Maryland 21017 (United States)

    2016-07-14

    The unique thermo-electro-mechanical properties of polycrystalline silicon carbide (poly-SiC) make it a desirable candidate for structural and electronic materials for operation in extreme environments. Necessitated by the need to understand how processing additives influence poly-SiC structure and electrical properties, the distribution of lattice defects and impurities across a specimen of hot-pressed 6H poly-SiC processed with p-type additives was visualized with high spatial resolution using a conductive atomic force microscopy approach in which a contact forming a nano-Schottky interface is scanned across the sample. The results reveal very intricate structures within poly-SiC, with each grain having a complex core-rim structure. This complexity results from the influence the additives have on the evolution of the microstructure during processing. It was found that the highest conductivities localized at rims as well as at the interface between the rim and the core. The conductivity of the cores is less than the conductivity of the rims due to a lower concentration of dopant. Analysis of the observed conductivities and current-voltage curves is presented in the context of nano-Schottky contact regimes where the conventional understanding of charge transport to diode operation is no longer valid.

  4. Obtaining thickness profiles from the tomographic inversion of guided wave data

    NARCIS (Netherlands)

    Bloom, J.G.P.; Luiten, E.A.; Volker, A.W.F.

    2009-01-01

    Guided wave tomography is a promising technique for the monitoring of corrosion over large areas. Guided waves have a wave speed mat depends in certain frequency-thickness regimes on the local thickness of the waveguide they follow. Therefore, the travel time of the guided wave over a fixed distance

  5. Embedding Piezoresistive Pressure Sensors to Obtain Online Pressure Profiles Inside Fiber Composite Laminates

    Directory of Open Access Journals (Sweden)

    Maryam Kahali Moghaddam

    2015-03-01

    Full Text Available The production of large and complex parts using fiber composite materials is costly due to the frequent formation of voids, porosity and waste products. By embedding different types of sensors and monitoring the process in real time, the amount of wastage can be significantly reduced. This work focuses on developing a knowledge-based method to improve and ensure complete impregnation of the fibers before initiation of the resin cure. Piezoresistive and capacitive pressure sensors were embedded in fiber composite laminates to measure the real-time the pressure values inside the laminate. A change of pressure indicates resin infusion. The sensors were placed in the laminate and the resin was infused by vacuum. The embedded piezoresistive pressure sensors were able to track the vacuum pressure in the fiber composite laminate setup, as well as the arrival of the resin at the sensor. The pressure increase due to closing the resin inlet was also measured. In contrast, the capacitive type of sensor was found to be inappropriate for measuring these quantities. The following study demonstrates real-time monitoring of pressure changes inside the fiber composite laminate, which validate the use of Darcy’s law in porous media to control the resin flow during infusion.

  6. Type II diabetes patients in primary care : profiles of healthcare utilization obtained from observational data

    NARCIS (Netherlands)

    van Dijk, C.E.; Hoekstra, T.; Verheij, R.A.; Twisk, J.W.R.; Groenewegen, P.P.; Schellevis, F.G.; et al, [No Value

    2013-01-01

    Background The high burden of diabetes for healthcare costs and their impact on quality of life and management of the disease have triggered the design and introduction of disease management programmes (DMPs) in many countries. The extent to which diabetes patients vary with regard to their

  7. Type II diabetes patients in primary care : Profiles of healthcare utilization obtained from observational data

    NARCIS (Netherlands)

    van Dijk, C.E.; Hoekstra, T.; Verheij, R.A.; Twisk, J.W.; Groenewegen, P.P.; Schellevis, F.G.; de Bakker, D.H.

    2013-01-01

    Background The high burden of diabetes for healthcare costs and their impact on quality of life and management of the disease have triggered the design and introduction of disease management programmes (DMPs) in many countries. The extent to which diabetes patients vary with regard to their

  8. Molecular weight profiles of proanthocyanidin polymers

    Science.gov (United States)

    Vincent M. Williams; Lawrence J. Porter; Richard W. Hemingway

    1983-01-01

    The MW profiles of proanthocyanidin polymers (condensed tannins) from 32 samples representing a wide range of plant tissues of many different species have been obtained by gel permeation chromatography of the peracetate derivatives. The tannins vary widely in MW, with M values for the peracetates in the range 1600-5500. The MW profiles vary greatly from those with...

  9. Caries risk profile of 12 year old school children in an Indian city using Cariogram

    Science.gov (United States)

    Ankola, Anil; Metgud, Sharada

    2012-01-01

    Objectives: The present study was conducted with an aim to assess the caries profile of 12 year old Indian children using Cariogram. Study design: Hundred children were interviewed to record any illness, oral hygiene practices and fluoride exposure after obtaining a three day diet diary. Examination was done to record plaque and dental caries status. Stimulated saliva was collected and salivary flow rate, salivary buffering capacity, Streptococcus mutans and Lactobacillus were assessed. The information obtained was scored and Cariogram was created. Differences between mean decayed, missing and filled teeth ( DMFT) and Cariogram risk groups were assessed using ANOVA. Spearman Correlation coefficients were used to explore correlation among Cariogram scores and individual variables. Results: It was found that 21, 45, 21 and 13 children had 0-20%, 21-40%, 41-60% and 61-100% chance of avoiding caries respectively in future. Significant correlation was observed between cariogram score and DMFT, diet content, diet frequency, plaque scores, Streptococcus mutans counts and fluoride programme. Conclusions: Cariogram model can identify the caries-related factors that could be the reasons for the estimated future caries risk, and therefore help the dentist to plan appropriate preventive measures. Key words:Cariogram, caries risk assessment, risk factors, children, India PMID:22926464

  10. Key performance indicators score (KPIs-score) based on clinical and laboratorial parameters can establish benchmarks for internal quality control in an ART program.

    Science.gov (United States)

    Franco, José G; Petersen, Claudia G; Mauri, Ana L; Vagnini, Laura D; Renzi, Adriana; Petersen, Bruna; Mattila, M C; Comar, Vanessa A; Ricci, Juliana; Dieamant, Felipe; Oliveira, João Batista A; Baruffi, Ricardo L R

    2017-06-01

    KPIs have been employed for internal quality control (IQC) in ART. However, clinical KPIs (C-KPIs) such as age, AMH and number of oocytes collected are never added to laboratory KPIs (L-KPIs), such as fertilization rate and morphological quality of the embryos for analysis, even though the final endpoint is the evaluation of clinical pregnancy rates. This paper analyzed if a KPIs-score strategy with clinical and laboratorial parameters could be used to establish benchmarks for IQC in ART cycles. In this prospective cohort study, 280 patients (36.4±4.3years) underwent ART. The total KPIs-score was obtained by the analysis of age, AMH (AMH Gen II ELISA/pre-mixing modified, Beckman Coulter Inc.), number of metaphase-II oocytes, fertilization rates and morphological quality of the embryonic lot. The total KPIs-score (C-KPIs+L-KPIs) was correlated with the presence or absence of clinical pregnancy. The relationship between the C-KPIs and L-KPIs scores was analyzed to establish quality standards, to increase the performance of clinical and laboratorial processes in ART. The logistic regression model (LRM), with respect to pregnancy and total KPIs-score (280 patients/102 clinical pregnancies), yielded an odds ratio of 1.24 (95%CI = 1.16-1.32). There was also a significant difference (pKPIs-score mean value between the group of patients with clinical pregnancies (total KPIs-score=20.4±3.7) and the group without clinical pregnancies (total KPIs-score=15.9±5). Clinical pregnancy probabilities (CPP) can be obtained using the LRM (prediction key) with the total KPIs-score as a predictor variable. The mean C-KPIs and L-KPIs scores obtained in the pregnancy group were 11.9±2.9 and 8.5±1.7, respectively. Routinely, in all cases where the C-KPIs score was ≥9, after the procedure, the L-KPIs score obtained was ≤6, a revision of the laboratory procedure was performed to assess quality standards. This total KPIs-score could set up benchmarks for clinical pregnancy. Moreover

  11. Examining Relationships among Assessment Scores and Math Coursework in an Urban School District

    Science.gov (United States)

    Parke, Carol S.

    2012-01-01

    This study investigates relationships between assessment scores and other indicators of math performance. The impetus for the research came from a district's need to better understand high school math achievement. Longitudinal data for a cohort of students were obtained, including math scores from their state assessment, TerraNova, and New…

  12. Autism Spectrum Disorder Scale Scores in Pediatric Mood and Anxiety Disorders

    Science.gov (United States)

    Pine, Daniel S.; Guyer, Amanda E.; Goldwin, Michelle; Towbin, Kenneth A.; Leibenluft, Ellen

    2008-01-01

    A study compares the scores on autism spectrum disorder (ASD) symptom scales in healthy children and in children with mood or anxiety disorders. It is observed that children with mood or anxiety disorders obtained higher scores on ASD symptom scales than healthy children.

  13. Validity of the FOUR Score Coma Scale in the Medical Intensive Care Unit

    Science.gov (United States)

    Iyer, Vivek N.; Mandrekar, Jayawant N.; Danielson, Richard D.; Zubkov, Alexander Y.; Elmer, Jennifer L.; Wijdicks, Eelco F. M.

    2009-01-01

    OBJECTIVE: To evaluate the validity of the FOUR (Full Outline of UnResponsiveness) score (ranging from 0 to 16), a new coma scale consisting of 4 components (eye response, motor response, brainstem reflexes, and respiration pattern), when used by the staff members of a medical intensive care unit (ICU). PATIENTS AND METHODS: This interobserver agreement study prospectively evaluated the use of the FOUR score to describe the condition of 100 critically ill patients from May 1, 2007, to April 30, 2008. We compared the FOUR score to the Glasgow Coma Scale (GCS) score. For each patient, the FOUR score and the GCS score were determined by a randomly selected staff pair (nurse/fellow, nurse/consultant, fellow/fellow, or fellow/consultant). Pair wise weighted κ values were calculated for both scores for each observer pair. RESULTS: The interrater agreement with the FOUR score was excellent (weighted κ: eye response, 0.96; motor response, 0.97; brainstem reflex, 0.98; respiration pattern, 1.00) and similar to that obtained with the GCS (weighted κ: eye response, 0.96; motor response, 0.97; verbal response, 0.98). In terms of the predictive power for poor neurologic outcome (Modified Rankin Scale score, 3-6), the area under the receiver operating characteristic curve was 0.75 for the FOUR score and 0.76 for the GCS score. The mortality rate for patients with the lowest FOUR score of 0 (89%) was higher than that for patients with the lowest GCS score of 3 (71%). CONCLUSION: The interrater agreement of FOUR score results was excellent among medical intensivists. In contrast to the GCS, all components of the FOUR score can be rated even when patients have undergone intubation. The FOUR score is a good predictor of the prognosis of critically ill patients and has important advantages over the GCS in the ICU setting. PMID:19648386

  14. Radiographic scoring system to evaluate union of distal radius fractures.

    Science.gov (United States)

    Patel, Shaun P; Anthony, Shawn G; Zurakowski, David; Didolkar, Manjiri M; Kim, Peter S; Wu, Jim S; Kung, Justin W; Dolan, Martin; Rozental, Tamara D

    2014-08-01

    To evaluate the intra- and interobserver reliability of a scoring system for distal radius fracture union based on specific radiographic parameters obtainable from x-rays. Two sets of 35 anteroposterior and lateral x-rays were obtained by retrospective review of consecutive patients with distal radius fractures (AO types A and C) treated by a single surgeon in 2009. One set was assembled for those patients treated nonsurgically and 1 set for those treated with open reduction and internal fixation (ORIF) with volar plating. Radius union scoring system (RUSS) scores were compiled from a 5-person review panel consisting of hand surgeons and musculoskeletal radiologists. Union of each of the 4 cortices was graded on a 3-point scale (0, fracture line visible with no callus; 1, callus formation but fracture line present; 2, cortical bridging without clear fracture line). Reviewers also recorded their overall impression of fracture union (united or not united). Each set of radiographs was reviewed twice by the 5 reviewers, 2 weeks apart. Inter- and intraobserver reliability were determined using intraclass correlation coefficients. For nonsurgically treated fractures, substantial agreement in union scores was found with regard to both intra- and interobserver reliability. For fractures treated with ORIF, substantial agreement was found in union scores with regard to intraobserver reliability and moderate agreement with regard to interobserver reliability. In addition, when using the reviewers' overall assessment of union as a reference standard, RUSS had a statistically significant predictive value in being able to differentiate between united and not united fractures. This radiographic union tool demonstrated substantial intra- and interobserver reliability for the determination of fracture union in the distal radius. The RUSS is a simple method for a standardized assessment of radiographic union of DRF treated nonsurgically or with ORIF. Economic/decision analysis IV

  15. Profiling and Racial Profiling: An Interactive Exercise

    Science.gov (United States)

    Semple, Philip

    2013-01-01

    Racial Profiling has been recognized as a serious problem that affects many segments of our society and is especially notable in law enforcement. Governments and police services have pronounced that racial profiling is not acceptable and will not be tolerated. They have gone to great lengths in trying to eradicate racial profiling through…

  16. Correlation between the different pH-metry scores in gastroesophageal reflux disease in children.

    Science.gov (United States)

    Lupu, Vasile Valeriu; Ignat, Ancuţa; Paduraru, Gabriela; Ciubara, Anamaria; Moscalu, Mihaela; Marginean, Cristina Oana; Burlea, Marin

    2016-06-01

    The 24-hour esophageal pH-metry is the most widely used method to diagnose the gastroesophageal reflux disease (GERD). The study compares the different scores obtained during the 24-hour esophageal pH-metry. A retrospective study over 5 years including 234 children (1 month and 18 years old) admitted in a pediatric gastroenterology regional center in Northeast Romania, with suspicion of GERD. They underwent 24- hour esophageal pH-metry, and the scores obtained (Boix-Ochoa, DeMeester, Johnson-DeMeester) were compared. Out of the 234 children, 172 (73.50%) had positive Boix-Ochoa score and 62 (26.50%) had normal Boix-Ochoa score (<11.99). Based on the DeMeester score, 149 children (63.68%) were positive and 85 (36.32%) were negative. The correlation of the Demeester score with the Boix-Ochoa score was very high (r = 0.978, P <  < 0.01, 95% confidence interval). Considering the Johnson-DeMeester score, 120 cases (51.28%) had GERD and 114 (48.72%) did not. The correlation of the Johnson-DeMeester score with the Boix-Ochoa score was still high (r = 0.94, P <  < 0.01, 95% 95% confidence interval). As considered until now, the Boix-Ochoa score is the most accurate score to be used in pediatrics for the diagnosis of GERD. The use of the different scores-Boix-Ochoa, DeMeester, Johnson-DeMeester-showed a high sensitivity and specificity of the pH-metry measurements applied to the study lot, but the last score has a higher risk of false-negative results.

  17. Perceived Stress Scores among Saudi Students Entering Universities: A Prospective Study during the First Year of University Life

    Directory of Open Access Journals (Sweden)

    Nasser M. Al-Daghri

    2014-04-01

    Full Text Available In this prospective study we wanted to determine whether perceived stress over time among students in the Preparatory Year of King Saud University (KSU predisposes them to cardiometabolic abnormalities. A total of 110 apparently healthy Saudi students (35 men and 75 women enrolled during the 2010−2011 academic year were included. Perceived stress was determined at baseline and 1 year later. Anthropometrics were obtained and morning fasting serum glucose, lipid profile and cortisol were measured at both times. Perceived stress was noted among 48.2% of subjects at baseline and was not significantly different after follow-up, with 45.4% scoring high. In men, the prevalence of perceived stress was 48.6% at baseline (13 out of 35 and 37.1% at follow-up (13 out of 35, while in women it was 48% at baseline and 49.3% at follow-up. Interestingly, significant improvements in the blood pressure and lipid profiles, with the exception of HDL-cholesterol, were observed in both men and women, while fasting glucose also improved in women. Serum cortisol was inversely associated to fasting glucose, and total- and LDL-cholesterol (p-values 0.007, 0.04 and 0.04, respectively. These data are opposite to findings in students entering Western universities, in whom increasing stress and a deteriorating cardiometabolic profile have been repeatedly noted. Perceived stress and morning cortisol levels among students of the Preparatory Year in KSU remained constant for both genders over time, yet an improved cardiometabolic profile was observed, suggesting good adaptation among our pre-college students in their first year of university life.

  18. Perceived stress scores among Saudi students entering universities: a prospective study during the first year of university life.

    Science.gov (United States)

    Al-Daghri, Nasser M; Al-Othman, Abdulaziz; Albanyan, Abdulmajeed; Al-Attas, Omar S; Alokail, Majed S; Sabico, Shaun; Chrousos, George P

    2014-04-10

    In this prospective study we wanted to determine whether perceived stress over time among students in the Preparatory Year of King Saud University (KSU) predisposes them to cardiometabolic abnormalities. A total of 110 apparently healthy Saudi students (35 men and 75 women enrolled during the 2010-2011 academic year) were included. Perceived stress was determined at baseline and 1 year later. Anthropometrics were obtained and morning fasting serum glucose, lipid profile and cortisol were measured at both times. Perceived stress was noted among 48.2% of subjects at baseline and was not significantly different after follow-up, with 45.4% scoring high. In men, the prevalence of perceived stress was 48.6% at baseline (13 out of 35) and 37.1% at follow-up (13 out of 35), while in women it was 48% at baseline and 49.3% at follow-up. Interestingly, significant improvements in the blood pressure and lipid profiles, with the exception of HDL-cholesterol, were observed in both men and women, while fasting glucose also improved in women. Serum cortisol was inversely associated to fasting glucose, and total- and LDL-cholesterol (p-values 0.007, 0.04 and 0.04, respectively). These data are opposite to findings in students entering Western universities, in whom increasing stress and a deteriorating cardiometabolic profile have been repeatedly noted. Perceived stress and morning cortisol levels among students of the Preparatory Year in KSU remained constant for both genders over time, yet an improved cardiometabolic profile was observed, suggesting good adaptation among our pre-college students in their first year of university life.

  19. Perceived Stress Scores among Saudi Students Entering Universities: A Prospective Study during the First Year of University Life

    Science.gov (United States)

    Al-Daghri, Nasser M.; Al-Othman, Abdulaziz; Albanyan, Abdulmajeed; Al-Attas, Omar S.; Alokail, Majed S.; Sabico, Shaun; Chrousos, George P.

    2014-01-01

    In this prospective study we wanted to determine whether perceived stress over time among students in the Preparatory Year of King Saud University (KSU) predisposes them to cardiometabolic abnormalities. A total of 110 apparently healthy Saudi students (35 men and 75 women enrolled during the 2010−2011 academic year) were included. Perceived stress was determined at baseline and 1 year later. Anthropometrics were obtained and morning fasting serum glucose, lipid profile and cortisol were measured at both times. Perceived stress was noted among 48.2% of subjects at baseline and was not significantly different after follow-up, with 45.4% scoring high. In men, the prevalence of perceived stress was 48.6% at baseline (13 out of 35) and 37.1% at follow-up (13 out of 35), while in women it was 48% at baseline and 49.3% at follow-up. Interestingly, significant improvements in the blood pressure and lipid profiles, with the exception of HDL-cholesterol, were observed in both men and women, while fasting glucose also improved in women. Serum cortisol was inversely associated to fasting glucose, and total- and LDL-cholesterol (p-values 0.007, 0.04 and 0.04, respectively). These data are opposite to findings in students entering Western universities, in whom increasing stress and a deteriorating cardiometabolic profile have been repeatedly noted. Perceived stress and morning cortisol levels among students of the Preparatory Year in KSU remained constant for both genders over time, yet an improved cardiometabolic profile was observed, suggesting good adaptation among our pre-college students in their first year of university life. PMID:24727357

  20. Does Field Reliability for Static-99 Scores Decrease as Scores Increase?

    Science.gov (United States)

    Rice, Amanda K.; Boccaccini, Marcus T.; Harris, Paige B.; Hawes, Samuel W.

    2015-01-01

    This study examined the field reliability of Static-99 (Hanson & Thornton, 2000) scores among 21,983 sex offenders and focused on whether rater agreement decreased as scores increased. As expected, agreement was lowest for high-scoring offenders. Initial and most recent Static-99 scores were identical for only about 40% of offenders who had been assigned a score of 6 during their initial evaluations, but for more than 60% of offenders who had been assigned a score of 2 or lower. In addition, the size of the difference between scores increased as scores increased, with pairs of scores differing by 2 or more points for about 30% of offenders scoring in the high-risk range. Because evaluators and systems use high Static-99 scores to identify sexual offenders who may require intensive supervision or even postrelease civil commitment, it is important to recognize that there may be more measurement error for high scores than low scores and to consider adopting procedures for minimizing or accounting for measurement error. PMID:24932647

  1. Comparative study of four maxillofacial trauma scoring systems and expert score.

    Science.gov (United States)

    Chen, Chen; Zhang, Yi; An, Jin-gang; He, Yang; Gong, Xi

    2014-11-01

    To select a scoring system suitable for the scoring of maxillofacial trauma by comparing 4 commonly used scoring systems according to expert scoring. Twenty-eight subjects who had experienced maxillofacial trauma constituted the study cohort. Four commonly used systems were selected: New Injury Severity Score (NISS), Facial Injury Severity Scale (FISS), Maxillofacial Injury Severity Score (MFISS), and Maxillofacial Injury Severity Score (MISS). Each patient was graded using these 4 systems. From the experience of our trauma center, an expert scoring table was created. After the purpose and scheme of the study had been explained, 35 experts in maxillofacial surgery were invited to grade the injury of the 28 patients using the expert scoring table according to their clinical experience. The results of the 4 scoring systems and expert score were compared. The results of the 4 scoring systems and expert score demonstrated a normal distribution. All results demonstrated significant differences (P maxillofacial injuries. Copyright © 2014 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.

  2. A system for obtaining an optical spectrum

    DEFF Research Database (Denmark)

    2013-01-01

    The present invention relates to a system for obtaining an optical spectrum 648 of analytes in a fluid sample, wherein a porous filter 602a, 602b is arranged so that the fluid sample may be placed onto a first region of the porous filter, and a SERS-active material 610a, 610b having a SERS...... the second region. Thereby, the porous filter enables that the fluid sample is filtered so that only sufficiently small entities in the fluid sample reach the second region where they may be probed so that an optical spectrum related to the analytes in the filtered sample may be obtained. The optical system...... also comprises a light source 634, a light detector 642, and the optical analysis system is arranged for obtaining the optical spectrum 648 of the analytes adjacent to the SERS-active material 610a, 610b exclusively from the second region of the porous filter 602a, 602b....

  3. The validity of self-reported physical fitness test scores.

    Science.gov (United States)

    Jones, Sarah B; Knapik, Joseph J; Sharp, Marilyn A; Darakjy, Salima; Jones, Bruce H

    2007-02-01

    Epidemiological studies often have to rely on a participant's self-reporting of information. The validity of the self-report instrument is an important consideration in any study. The purpose of this investigation was to determine the validity of self-reported Army Physical Fitness Test (APFT) scores. The APFT is administered to all soldiers in the U.S. Army twice a year and consists of the maximum number of push-ups completed in 2 minutes, the maximum number of sit-ups completed in 2 minutes, and a 2-mile run for time. Army mechanics responded to a questionnaire in March and June 2004 asking them to report the exact scores of each event on their most recent APFT. Actual APFT scores were obtained from the soldier's military unit. The mean +/- standard deviation (SD) of actual and self-reported numbers of push-ups was 61 +/- 14 and 65 +/- 13, respectively. The mean +/- SD of actual and self-reported numbers of sit-ups were 66 +/- 10 and 68 +/- 10, respectively. The mean +/- SD of actual and self-reported run times (minutes) were 14.8 +/- 1.4 and 14.6 +/- 1.4, respectively. Correlations between actual and self-reported push-ups, sit-ups, and run were 0.83, 0.71, and 0.85, respectively. On average, soldiers tended to slightly over-report performance on all APFT events and individual self-reported scores could vary widely from actual scores based on Bland-Altman plots. Despite this, the close correlations between the actual and self-reported scores suggest that self-reported values are adequate for most epidemiological military studies involving larger sample sizes.

  4. A Predictive Model for USMLE Step 1 Scores.

    Science.gov (United States)

    Giordano, Christin; Hutchinson, David; Peppler, Richard

    2016-09-07

    The United States Medical Licensing Examination (USMLE) Step 1 plays a pivotal role in one's residency application. While prior literature has investigated which factors influence performance on the examination, the authors sought to include factors such as performance on a well-used question bank and financial need to develop a predictive model. After obtaining institutional review board approval, the authors surveyed two consecutive second-year medical school classes and correlated the data to the students' Step 1 and National Board of Medical Examiners (NBME) Comprehensive Basic Science Examination (CBSE) scores. The survey included questions such as how many days they studied per week, how many days they studied in total, which resources they used, how they performed on question banks, group studying habits, and whether they were receiving financial aid. The authors also assessed whether the students received only A letter grades during the first year of medical school. The authors used SPSS® Statistics V22.0 (IBM® Corporation, NY, USA ) and included one-way analysis of covariance (ANOVA) and multiple linear regression for statistical analysis. Eighty-one students completed the survey with an average Step 1 score of 240.5 and with an average study time of 39.5 days. The Step 1 Scores significantly correlated with the CBSE taken immediately preceding the dedicated study period (r=0.711, P=CBSE=the three-digit score of the CBSE taken prior to the dedicated study period. Academic performance and financial need may predict Step 1 scores. Interestingly, the number of days studied did not have a correlation with scores, suggesting that increased length of study may not ameliorate poor grades.

  5. Lifestyle Cardiovascular Risk Score, Genetic Risk Score, and Myocardial Infarction in Hispanic/Latino Adults Living in Costa Rica.

    Science.gov (United States)

    Sotos-Prieto, Mercedes; Baylin, Ana; Campos, Hannia; Qi, Lu; Mattei, Josiemer

    2016-12-20

    A lifestyle cardiovascular risk score (LCRS) and a genetic risk score (GRS) have been independently associated with myocardial infarction (MI) in Hispanics/Latinos. Interaction or joint association between these scores has not been examined. Thus, our aim was to assess interactive and joint associations between LCRS and GRS, and each individual lifestyle risk factor, on likelihood of MI. Data included 1534 Costa Rican adults with nonfatal acute MI and 1534 matched controls. The LCRS used estimated coefficients as weights for each factor: unhealthy diet, physical inactivity, smoking, elevated waist:hip ratio, low/high alcohol intake, low socioeconomic status. The GRS included 14 MI-associated risk alleles. Conditional logistic regressions were used to calculate adjusted odds ratios. The odds ratios for MI were 2.72 (2.33, 3.17) per LCRS unit and 1.13 (95% CI 1.06, 1.21) per GRS unit. A significant joint association for highest GRS tertile and highest LCRS tertile and odds of MI was detected (odds ratio=5.43 [3.71, 7.94]; Plifestyle and unfavorable genetic profile, and 5.02 (3.46, 7.29) under unhealthy lifestyle but advantageous genetic profile. Significant joint associations were observed for the highest GRS tertile and the highest of each lifestyle component risk category. The interaction term was nonsignificant (P=0.33). Lifestyle risk factors and genetics are jointly associated with higher odds of MI among Hispanics/Latinos. Individual and combined lifestyle risk factors showed stronger associations. Efforts to improve lifestyle behaviors could help prevent MI regardless of genetic susceptibility. © 2016 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.

  6. Experiments for obtaining field influence mass particles.

    CERN Document Server

    Yahalomi, E

    2010-01-01

    Analyzing time dilation experiments the existence of a universal field interacting with moving mass particles is obtained. It is found that mass particle changes its properties depend on its velocity relative to this universal scalar field and not on its velocity relative to the laboratory. High energy proton momentum, energy and mass were calculated obtaining new results. Experiments in high energy accelerators are suggested as additional proofs for the existence of this universal field. This universal field may explain some results of other high energy experiments.

  7. Personality profiles of recreational scuba divers | Coetzee | African ...

    African Journals Online (AJOL)

    Frequency tables revealed high scores on self-sufficiency, boldness and impulsivity and low scores on conformity, warmth and sensitivity. The findings indicated that divers' personality traits differ from what the literature indicated to be typical of the extreme athlete's personality profile. An exploratory factor analysis was ...

  8. The apgar score and infant mortality.

    Science.gov (United States)

    Li, Fei; Wu, Ting; Lei, Xiaoping; Zhang, Hao; Mao, Meng; Zhang, Jun

    2013-01-01

    To evaluate if the Apgar score remains pertinent in contemporary practice after more than 50 years of wide use, and to assess the value of the Apgar score in predicting infant survival, expanding from the neonatal to the post-neonatal period. The U.S. linked live birth and infant death dataset was used, which included 25,168,052 singleton births and 768,305 twin births. The outcome of interest was infant death within 1 year after birth. Cox proportional hazard-model was used to estimate risk ratio of infant mortality with different Apgar scores. Among births with a very low Apgar score at five minutes (1-3), the neonatal and post-neonatal mortality rates remained high until term (≥ 37 weeks). On the other hand, among births with a high Apgar score (≥7), neonatal and post-neonatal mortality rate decreased progressively with gestational age. Non-Hispanic White had a consistently higher neonatal mortality than non-Hispanic Black in both preterm and term births. However, for post-neonatal mortality, Black had significantly higher rate than White. The pattern of changes in neonatal and post-neonatal mortality by Apgar score in twin births is essentially the same as that in singleton births. The Apgar score system has continuing value for predicting neonatal and post-neonatal adverse outcomes in term as well as preterm infants, and is applicable to twins and in various race/ethnic groups.

  9. THE EFFICIENCY OF TENNIS DOUBLES SCORING SYSTEMS

    Directory of Open Access Journals (Sweden)

    Geoff Pollard

    2010-09-01

    Full Text Available In this paper a family of scoring systems for tennis doubles for testing the hypothesis that pair A is better than pair B versus the alternative hypothesis that pair B is better than A, is established. This family or benchmark of scoring systems can be used as a benchmark against which the efficiency of any doubles scoring system can be assessed. Thus, the formula for the efficiency of any doubles scoring system is derived. As in tennis singles, one scoring system based on the play-the-loser structure is shown to be more efficient than the benchmark systems. An expression for the relative efficiency of two doubles scoring systems is derived. Thus, the relative efficiency of the various scoring systems presently used in doubles can be assessed. The methods of this paper can be extended to a match between two teams of 2, 4, 8, …doubles pairs, so that it is possible to establish a measure for the relative efficiency of the various systems used for tennis contests between teams of players.

  10. The apgar score and infant mortality.

    Directory of Open Access Journals (Sweden)

    Fei Li

    Full Text Available OBJECTIVE: To evaluate if the Apgar score remains pertinent in contemporary practice after more than 50 years of wide use, and to assess the value of the Apgar score in predicting infant survival, expanding from the neonatal to the post-neonatal period. METHODS: The U.S. linked live birth and infant death dataset was used, which included 25,168,052 singleton births and 768,305 twin births. The outcome of interest was infant death within 1 year after birth. Cox proportional hazard-model was used to estimate risk ratio of infant mortality with different Apgar scores. RESULTS: Among births with a very low Apgar score at five minutes (1-3, the neonatal and post-neonatal mortality rates remained high until term (≥ 37 weeks. On the other hand, among births with a high Apgar score (≥7, neonatal and post-neonatal mortality rate decreased progressively with gestational age. Non-Hispanic White had a consistently higher neonatal mortality than non-Hispanic Black in both preterm and term births. However, for post-neonatal mortality, Black had significantly higher rate than White. The pattern of changes in neonatal and post-neonatal mortality by Apgar score in twin births is essentially the same as that in singleton births. CONCLUSIONS: The Apgar score system has continuing value for predicting neonatal and post-neonatal adverse outcomes in term as well as preterm infants, and is applicable to twins and in various race/ethnic groups.

  11. UFO: a web server for ultra-fast functional profiling of whole genome protein sequences.

    Science.gov (United States)

    Meinicke, Peter

    2009-09-02

    Functional profiling is a key technique to characterize and compare the functional potential of entire genomes. The estimation of profiles according to an assignment of sequences to functional categories is a computationally expensive task because it requires the comparison of all protein sequences from a genome with a usually large database of annotated sequences or sequence families. Based on machine learning techniques for Pfam domain detection, the UFO web server for ultra-fast functional profiling allows researchers to process large protein sequence collections instantaneously. Besides the frequencies of Pfam and GO categories, the user also obtains the sequence specific assignments to Pfam domain families. In addition, a comparison with existing genomes provides dissimilarity scores with respect to 821 reference proteomes. Considering the underlying UFO domain detection, the results on 206 test genomes indicate a high sensitivity of the approach. In comparison with current state-of-the-art HMMs, the runtime measurements show a considerable speed up in the range of four orders of magnitude. For an average size prokaryotic genome, the computation of a functional profile together with its comparison typically requires about 10 seconds of processing time. For the first time the UFO web server makes it possible to get a quick overview on the functional inventory of newly sequenced organisms. The genome scale comparison with a large number of precomputed profiles allows a first guess about functionally related organisms. The service is freely available and does not require user registration or specification of a valid email address.

  12. Investigating the Value of Section Scores for the "TOEFL iBT"® Test. "TOEFL iBT"® Research Report. TOEFL iBT-21. ETS Research Report RR-13-35

    Science.gov (United States)

    Sawaki, Yasuyo; Sinharay, Sandip

    2013-01-01

    This study investigates the value of reporting the reading, listening, speaking, and writing section scores for the "TOEFL iBT"® test, focusing on 4 related aspects of the psychometric quality of the TOEFL iBT section scores: reliability of the section scores, dimensionality of the test, presence of distinct score profiles, and the…

  13. A comparison between modified Alvarado score and RIPASA score in the diagnosis of acute appendicitis.

    Science.gov (United States)

    Singla, Anand; Singla, Satpaul; Singh, Mohinder; Singla, Deeksha

    2016-12-01

    Acute appendicitis is a common but elusive surgical condition and remains a diagnostic dilemma. It has many clinical mimickers and diagnosis is primarily made on clinical grounds, leading to the evolution of clinical scoring systems for pin pointing the right diagnosis. The modified Alvarado and RIPASA scoring systems are two important scoring systems, for diagnosis of acute appendicitis. We prospectively compared the two scoring systems for diagnosing acute appendicitis in 50 patients presenting with right iliac fossa pain. The RIPASA score correctly classified 88 % of patients with histologically confirmed acute appendicitis compared with 48.0 % with modified Alvarado score, indicating that RIPASA score is more superior to Modified Alvarado score in our clinical settings.

  14. Cardiovascular Outcomes in the Outpatient Kidney Transplant Clinic: The Framingham Risk Score Revisited

    OpenAIRE

    Kiberd, Bryce; Panek, Romuald

    2008-01-01

    Background and objectives: Cardiovascular disease is an important cause of morbidity and death in kidney transplant recipients. This study examines the Framingham risk score's ability to predict cardiac and stroke events. Because cyclosporine and tacrolimus have different cardiovascular risk profiles, these agents were also examined.

  15. Scoring biosecurity in European conventional broiler production.

    Science.gov (United States)

    Van Limbergen, T; Dewulf, J; Klinkenberg, M; Ducatelle, R; Gelaude, P; Méndez, J; Heinola, K; Papasolomontos, S; Szeleszczuk, P; Maes, D

    2018-01-01

    Good biosecurity procedures are crucial for healthy animal production. The aim of this study was to quantify the level of biosecurity on conventional broiler farms in Europe, following a standardized procedure, thereby trying to identify factors that are amenable to improvement. The current study used a risk-based weighted scoring system (biocheck.ugent ®) to assess the level of biosecurity on 399 conventional broiler farms in 5 EU member states. The scoring system consisted of 2 main categories, namely external and internal biosecurity, which had 8 and 3 subcategories, respectively. Biosecurity was quantified by converting the answers to 97 questions into a score from 0 to 100. The minimum score, "0," represents total absence of any biosecurity measure on the broiler farm, whereas the maximum score, "100," means full application of all investigated biosecurity measures. A possible correlation between biosecurity and farm characteristics was investigated by multivariate linear regression analysis. The participating broiler farms scored better for internal biosecurity (mean score of 76.6) than for external biosecurity (mean 68.4). There was variation between the mean biosecurity scores for the different member states, ranging from 59.8 to 78.0 for external biosecurity and from 63.0 to 85.6 for internal biosecurity. Within the category of external biosecurity, the subcategory related to "infrastructure and vectors" had the highest mean score (82.4), while the subcategory with the lowest score related to biosecurity procedures for "visitors and staff" (mean 51.5). Within the category of internal biosecurity, the subcategory "disease management" had the highest mean score (65.8). In the multivariate regression model a significant negative correlation was found between internal biosecurity and the number of employees and farm size. These findings indicate that there is a lot of variation for external and internal biosecurity on the participating broiler farms

  16. Prognostic Value of TIMI Score versus GRACE Score in ST-segment Elevation Myocardial Infarction

    OpenAIRE

    Correia, Luis C. L.; Guilherme Garcia; Felipe Kalil; Felipe Ferreira; Manuela Carvalhal; Ruan Oliveira; André Silva; Isis Vasconcelos; Caio Henri; Márcia Noya-Rabelo

    2014-01-01

    Background: The TIMI Score for ST-segment elevation myocardial infarction (STEMI) was created and validated specifically for this clinical scenario, while the GRACE score is generic to any type of acute coronary syndrome. Objective: Between TIMI and GRACE scores, identify the one of better prognostic performance in patients with STEMI. Methods: We included 152 individuals consecutively admitted for STEMI. The TIMI and GRACE scores were tested for their discriminatory ability (C-stati...

  17. Obtaining a minimal set of rewrite rules

    CSIR Research Space (South Africa)

    Davel, M

    2005-11-01

    Full Text Available In this paper the authors describe a new approach to rewrite rule extraction and analysis, using Minimal Representation Graphs. This approach provides a mechanism for obtaining the smallest possible rule set – within a context-dependent rewrite rule...

  18. Reverse technology transfer; obtaining feedback from managers.

    Science.gov (United States)

    A.B. Carey; J.M. Calhoun; B. Dick; K. O' Halloran; L.S. Young; R.E. Bigley; S. Chan; C.A. Harrington; J.P. Hayes; J. Marzluff

    1999-01-01

    Forestry policy, planning, and practice have changed rapidly with implementation of ecosystem management by federal, state, tribal, and private organizations. Implementation entails new concepts, terminology, and management approaches. Yet there seems to have been little organized effort to obtain feedback from on-the-ground managers on the practicality of implementing...

  19. Strategies for obtaining unpublished drug trial data

    DEFF Research Database (Denmark)

    Wolfe, Nicole; Gøtzsche, Peter C.; Bero, Lisa Anne

    2013-01-01

    Authors of systematic reviews have difficulty obtaining unpublished data for their reviews. This project aimed to provide an in-depth description of the experiences of authors in searching for and gaining access to unpublished data for their systematic reviews, and to give guidance on best practi...

  20. Obtaining evapotranspiration and surface energy fluxes with ...

    African Journals Online (AJOL)

    In this study, SEBAL (Surface Energy Balance Algorithm for Land), a remote sensing based evapotranspiration model, has been applied with Landsat ETM+ sensor for the estimation of actual ... The land uses in this study area consists of irrigated agriculture, rain-fed agriculture and livestock grazing. The obtained results ...

  1. Obtaining the Andersen's chart, triangulation algorithm

    DEFF Research Database (Denmark)

    Sabaliauskas, Tomas; Ibsen, Lars Bo

    Andersen’s chart (Andersen & Berre, 1999) is a graphical method of observing cyclic soil response. It allows observing soil response to various stress amplitudes that can lead to liquefaction, excess plastic deformation or stabilizing soil response. The process of obtaining the original chart has...

  2. Isolation and characterization of microcrystalline cellulose obtained ...

    African Journals Online (AJOL)

    In this study, microcrystalline cellulose, coded MCC-PNF, was obtained from palm nut (Elaeis guineensis) fibres. MCC-PNF was examined for its physicochemical and powder properties. The powder properties of MCC-PNF were compared to those of the best commercial microcrystalline cellulose grade, Avicel PH 101.

  3. A new method for obtaining transparent electrodes

    DEFF Research Database (Denmark)

    Malureanu, Radu; Zalkovskij, Maksim; Song, Zhengyong

    2012-01-01

    In this article, we propose a simple scheme to make a metallic film on a semi-infinite substrate optically transparent, thus obtaining a completely transparent electrode in a desired frequency range. By placing a composite layer consisting of dielectric and metallic stripes on top of the metallic...

  4. Production and characterization of pectinases obtained from ...

    African Journals Online (AJOL)

    Production and characterization of pectinases obtained from Aspergillus fumigatus in submerged fermentation system using pectin extracted from mango peels as ... The pectinase was used to degrade pectins extracted from orange and pineapple peels and its specific activities were found to be 30U/mg and 28.39U/mg ...

  5. Enhancing Physician Assistant Student Clinical Rotation Evaluations With the RIME Scoring Format: A Retrospective 3-Year Analysis.

    Science.gov (United States)

    Klocko, David J

    2016-11-03

    This article describes a 3-year retrospective analysis of student clinical rotation evaluations using the Reporter-Interpreter-Manager-Educator (RIME) scoring format. The intent of the analysis was to assess scoring trends to determine whether students with high scores on the Physician Assistant National Certifying Exam (PANCE) also achieved high RIME scores on clinical rotations. The top and bottom quartiles of PANCE scores were identified for the University of Texas (UT) Southwestern Medical Center's physician assistant (PA) classes of 2010-2012 (n = 106). RIME scores for the top and bottom quartiles of students (n = 54) also were identified. RIME scores for the same cohort of students were analyzed using the top and bottom quartiles of students' PANCE scores. The Wilcoxon matched-pairs signed rank test revealed that students with top quartile PANCE scores received a higher aggregate RIME score of 557 compared with the lower quartile of PANCE performers' score of 520 (P < .03). Results for RIME scoring trends, PANCE scores, and end-of-rotation examination scores are presented. Students from the UT Southwestern Medical Center's PA classes of 2010-2012 obtained a Manager classification most often (52%), and students with higher PANCE scores also received higher RIME scores on clinical rotations.

  6. Profile Similarity Metrics Increase Personality Scale Validity (Briefing Charts)

    Science.gov (United States)

    2016-04-15

    unless so designated by other documentation. Personality Tests • Modest scale validity & minor adverse impact • Scale scores often computed as the mean ...Profile Similarity Metrics Increase Personality Scale Validity Peter J. Legree, Robert N. Kilcullen U.S. Army Research Institute for the Behavioral... Personality Tests & Distance Metrics • Conventional and distance scores are redundant: r = -1.00 3 Fitness Motivation Rating Conventional Score Key Distance

  7. Comparison of scores on the MMPI-A and MMPI-2 for young adults.

    Science.gov (United States)

    Gumbiner, J

    1997-12-01

    Male college students' profiles look more pathological on the adult version of the MMPI than on the adolescent version. In the present study, men showed elevated scores on the F, Pa, and Sc scales on the MMPI-2. In contrast, women's profiles were more normal on the adult version. When designing the MMPI-A, the authors attempted to maintain correspondence with the original MMPI and the MMPI-2 so the scales could be interpreted similarly. This study compared scores on the MMPI-A and MMPI-2 by administering both tests to the same subjects (N = 43; 19 men and 24 women). Validity and standard scale scores were compared using Pearson product-moment correlations (r), T-score means and standard deviations, and average profiles. Codetype comparisons were also made. In general, MMPI-A and MMPI-2 codetype analyses did not agree. The codetype approach is not recommended for interpretation of the MMPI-A. The finding that young college men show elevated scores on MMPI-2 scales is consistent with previous research and suggests that the MMPI-A may be a useful tool for 18-yr.-old men.

  8. Language ability in the intermediate-scoring group of hearing-impaired children.

    Science.gov (United States)

    Sugaya, Akiko; Fukushima, Kunihiro; Kasai, Norio; Fujiyoshi, Akie; Taguchi, Tomoko; Omori, Kana; Ojima, Toshiyuki; Nishizaki, Kazunori

    2012-04-01

    Language development is a key issue in hearing-impaired children. However, interpersonal differences complicate our understanding of the situation. The bimodal or trimodal distribution of language scores in our other reports in this publication imply the presence of fundamental differences among these groups. The characteristic aspects of each group were profiled according to language data. We divided 268 children with prelingual severe to profound hearing impairment into 3 groups according to their trimodal distribution observed on histogram-based analysis of their responses to the Test of Question-Answer Interaction Development. Test results in several language domains, including productive and comprehensive vocabulary, productive and comprehensive syntax, and academic achievement, were profiled and compared among these 3 groups. Significant differences were observed in the results of the Word Fluency Test, the Picture Vocabulary Test-Revised, and the Syntax Test of Aphasia among the 3 groups. No significant difference was observed between groups who were lower-scoring and intermediate-scoring on the academic achievement tests referred to as Criterion Referenced Test-II and the Standardized Comprehension Test for Abstract Words. Only the higher-scoring group showed excellent results. The demographic factors were not significantly different among the 3 groups. Relatively poor academic achievement despite fair language production was the dominant feature of the intermediate-scoring group. This profile might correlate with academic failure in school.

  9. Facilitating the Interpretation of English Language Proficiency Scores: Combining Scale Anchoring and Test Score Mapping Methodologies

    Science.gov (United States)

    Powers, Donald; Schedl, Mary; Papageorgiou, Spiros

    2017-01-01

    The aim of this study was to develop, for the benefit of both test takers and test score users, enhanced "TOEFL ITP"® test score reports that go beyond the simple numerical scores that are currently reported. To do so, we applied traditional scale anchoring (proficiency scaling) to item difficulty data in order to develop performance…

  10. Pooling score: an endoscopic model for evaluating severity of dysphagia.

    Science.gov (United States)

    Farneti, D

    2008-06-01

    The finding of secretions and bolus pooling is of great diagnostic interest in the evaluation of subjects with swallowing disorders. Bedside evaluation alone, in subjects at risk for aspiration, can underestimate this parameter. The usefulness of endoscopic investigation for the evaluation of subjects with swallowing disorders is stressed, in order to plan treatment and follow-up. Based on endoscopic evaluation of material pooling we devised a score expressing the severity of dysphagia. This value takes into account endoscopic landmarks and other parameters of bedside evaluation. Endoscopic and bedside data were collected from a heterogeneous population of 520 consecutive patients seen in our Service over a 6-year period. By means of the test of equality of group means and logistic regression, parameters able to significantly predict aspiration in the series were identified. An ordinal number was attributed to each parameter in order to obtain scores expressing three degrees of severity of dysphagia: mild, moderate, severe. The scores can be used to guide the management of patients in a simple way, providing indications for targeted referral to the speech pathologist and for tracking the disorder over time. This investigation represents the basis for future research aimed at validating the scores in a larger case series.

  11. Automatic recognition and scoring of olympic rhythmic gymnastic movements.

    Science.gov (United States)

    Díaz-Pereira, M Pino; Gómez-Conde, Iván; Escalona, Merly; Olivieri, David N

    2014-04-01

    We describe a conceptually simple algorithm for assigning judgement scores to rhythmic gymnastic movements, which could improve scoring objectivity and reduce judgemental bias during competitions. Our method, implemented as a real-time computer vision software, takes a video shot or a live performance video stream as input and extracts detailed velocity field information from body movements, transforming them into specialized spatio-temporal image templates. The collection of such images over time, when projected into a velocity covariance eigenspace, trace out unique but similar trajectories for a particular gymnastic movement type. By comparing separate executions of the same atomic gymnastic routine, our method assigns a quality judgement score that is related to the distance between the respective spatio-temporal trajectories. For several standard gymnastic movements, the method accurately assigns scores that are comparable to those assigned by expert judges. We also describe our rhythmic gymnastic video shot database, which we have made freely available to the human movement research community. The database can be obtained at http://www.milegroup.net/apps/gymdb/. Copyright © 2014 Elsevier B.V. All rights reserved.

  12. The Changes of Students’ Toefl Score After One Year Learning

    Directory of Open Access Journals (Sweden)

    Ienneke Indra Dewi

    2015-10-01

    Full Text Available BINUS students are supposed to increase their English competence indicated by their TOEFL scores. This paper aims to observe the differences between studens TOEFL scores obtained when they entered BINUS and the scores after they joined TOEFL courses at BINUS for one year. The participants were 121 students. The data for the entrance test were taken from the BINUS data center and the final test data were taken from their final test at English class. The data were analysed using statistics especially the descriptive statistics, comparing means, and correlation. To support the quantative data, a set of questionnaires was distributed to those 121 students. The results show that the students’ TOEFL scores have increased significantly in the final test compared to those in the entrance test. The low achiever students showed a better performance than the higher ones. Students’ motivation and background support their English study. Students proved to have the most problem in listening. The results of the research are expected to be the input for English lecturers to improve their teaching especially the existence of SALLC (Self Access Language Learning Center. 

  13. A bedside scoring system ("Candida score") for early antifungal treatment in nonneutropenic critically ill patients with Candida colonization.

    Science.gov (United States)

    León, Cristóbal; Ruiz-Santana, Sergio; Saavedra, Pedro; Almirante, Benito; Nolla-Salas, Juan; Alvarez-Lerma, Francisco; Garnacho-Montero, José; León, María Angeles

    2006-03-01

    To obtain a score for deciding early antifungal treatment when candidal infection is suspected in nonneutropenic critically ill patients. Analysis of data collected from the database of the EPCAN project, an ongoing prospective, cohort, observational, multicenter surveillance study of fungal infection and colonization in intensive care unit (ICU) patients. Seventy-three medical-surgical ICUs of 70 teaching hospitals in Spain. A total of 1,699 ICU patients aged 18 yrs and older admitted for at least 7 days between May 1998 and January 1999 were studied. Surveillance cultures of urine, tracheal, and gastric samples were obtained weekly. Patients were grouped as follows: neither colonized nor infected (n=719), unifocal or multifocal Candida colonization (n=883), and proven candidal infection (n=97). The odds ratio (OR) for each risk factor associated with colonization vs. proven candidal infection was estimated. A logistic regression model was performed to adjust for possible confounders. The "Candida score" was obtained according to the logit method. The discriminatory power was evaluated by the area under the receiver operating characteristics curve. In the logit model, surgery (OR=2.71, 95% confidence interval [CI], 1.45-5.06); multifocal colonization (OR=3.04, 95% CI, 1.45-6.39); total parenteral nutrition (OR=2.48, 95% CI, 1.16-5.31); and severe sepsis (OR=7.68, 95% CI, 4.14-14.22) were predictors of proven candidal infection. The "Candida score" for a cut-off value of 2.5 (sensitivity 81%, specificity 74%) was as follows: parenteral nutrition, +0.908; surgery, +0.997; multifocal colonization, +1.112; and severe sepsis, +2.038. Central venous catheters were not a significant risk factor for proven candidal infection (p=.292). In a large cohort of nonneutropenic critically ill patients in whom Candida colonization was prospectively assessed, a "Candida score">2.5 accurately selected patients who would benefit from early antifungal treatment.

  14. Using the Bologna Score to assess normal delivery healthcare

    Directory of Open Access Journals (Sweden)

    Isaiane da Silva Carvalho

    Full Text Available Abstract OBJECTIVE Describing the obstetric care provided in public maternity hospitals during normal labour using the Bologna Score in the city of Natal, Northeastern Brazil. METHOD A quantitative cross-sectional study conducted with 314 puerperal women. Data collection was carried out consecutively during the months of March to July 2014. RESULTS Prenatal care was provided to 95.9% of the mothers, beginning around the 1st trimester of pregnancy (72.3% and having seven or more consultations (51%. Spontaneous vaginal delivery was planned for 88.2% women. All laboring women were assisted by a health professional, mostly by a physician (80.6%, and none of them obtained 5 points on the Bologna Score due to the small percentage of births in non-supine position (0.3% and absence of a partogram (2.2%. A higher number of episiotomies were observed among primiparous women (75.5%. CONCLUSION The score obtained using the Bologna Index was low. Thus, it is necessary to improve and readjust the existing obstetrical model.

  15. Climiate Resilience Screening Index and Domain Scores

    Data.gov (United States)

    U.S. Environmental Protection Agency — CRSI and related-domain scores for all 50 states and 3135 counties in the U.S. This dataset is not publicly accessible because: They are already available within the...

  16. GMAT Scores of Undergraduate Economics Majors

    Science.gov (United States)

    Nelson, Paul A.; Monson, Terry D.

    2008-01-01

    The average score of economics majors on the Graduate Management Admission Test (GMAT) exceeds those of nearly all humanities and arts, social sciences, and business undergraduate majors but not those of most science, engineering, and mathematics majors. (Contains 1 table.)

  17. (IPSS) and Visual Prostate Symptoms Score

    African Journals Online (AJOL)

    O.O. Abiola

    2016-01-12

    VPSS) and International Prostate. Symptoms Score (IPSS) questionnaires for the assessment of lower urinary tract symptoms (LUTS) in. Nigerian men, with special emphasis on the ease of administration and the time needed ...

  18. New clinical score to diagnose nonalcoholic steatohepatitis in obese patients

    Directory of Open Access Journals (Sweden)

    Pulzi Fernanda BU

    2011-02-01

    Full Text Available Abstract Background Nonalcoholic fatty liver disease (NAFLD is the most frequent disease associated with abnormal liver tests that is characterized by a wide spectrum of liver damage, ranging from simple macro vesicular steatosis to steatohepatitis (NASH, cirrhosis or liver carcinoma. Liver biopsy is the most precise test to differentiate NASH from other stages of NAFLD, but it is an invasive and expensive method. This study aimed to create a clinical laboratory score capable of identify individual with NASH in severely obese patients submitted to bariatric surgery. Methods The medical records from 66 patients submitted to gastroplasty were reviewed. Their chemistry profile, abdominal ultrasound (US and liver biopsy done during the surgical procedure were analyzed. Patients were classified into 2 groups according to liver biopsy: Non-NASH group - those patients without NAFLD or with grade I, II or III steatosis; and NASH group - those with steatohepatitis or fibrosis. The t-test was used to compare each variable with normal distribution between NASH and Non-NASH groups. When comparing proportions of categorical variables, we used chi-square or z-test, where appropriate. A p-value Results 83% of patients with obesity grades II or III showed NAFLD, and the majority was asymptomatic. Total Cholesterol (TC≥200 mg/dL, alanine aminotransferase (ALT ≥30, AST/ALT ratio (AAR≤ 1, gammaglutaril-transferase (γGT≥30 U/L and abdominal US, compatible with steatosis, showed association with NASH group. We proposed 2 scores: Complete score (TC, ALT, AAR, γGT and US and the simplified score, where US was not included. The combination of biochemical and imaging results improved accuracy to 84.4% the recognition of NASH (sensitivity 70%, specificity 88.6%, NPV 91.2%, PPV 63. 6%. Conclusion Alterations in TC, ALT, AAR, γGT and US are related to the most risk for NASH. The combination of biochemical and imaging results improved accuracy to 84.4% the

  19. Martial arts intervention decreases pain scores in children with malignancy.

    Science.gov (United States)

    Bluth, Martin H; Thomas, Ronald; Cohen, Cindy; Bluth, Amanda C; Goldberg, Elimelech

    2016-01-01

    Martial arts intervention in disease has been mostly limited to adult inflammatory, musculoskeletal, or motor diseases, where a mechanical intervention effects positive change. However, the application and benefit to pain management in childhood malignancy are not well described. Here, we assess the effects of defined martial arts intervention in children with cancer with respect to their pain perception and management. Sixty-four children with childhood malignancies were enrolled in a martial arts program, which encompassed both meditation and movement modalities. Pain scores (0-10) were recorded pre- and post- 1-hour session intervention. Pain scores were crossed by total visits and tabulated by whether participant pain reduced at least 1 unit, stayed the same, or increased in intensity immediately after (post) participation session. Differences in pain scores were further compared by age and sex. Prepain and postpain scale data were measured for 64 participants, 43 males (67.2%) and 21 females (32.8%), ranging from 3 years to 19 years. Preintervention and postintervention data were obtained for 223 individual session visits. Mean number of patient participation visits was 1.8±1.6 (range one to nine visits). Of 116 individual measured sessions where the participants began with a pain score of at least 1, pain intensity reduced ≥1 unit in 85.3% (99/116) of visits, remained the same in 7.8% (9/116), and increased in 6.9% (8/116). For the majority (96.3%; 77/80) of sessions, participants began with a prepain intensity score of at least 5-10 with reduction in pain intensity following the session. The overall mean pain score presession visit was reduced bŷ40% (pre: 5.95±2.64 and post: 3.03±2.45 [95% CI: 2.34-3.50]; P ≤0.001). Median pain intensity scores had greater reductions with increased age of participants (3-6 years [-1], 7-10 years [-2], 11-14 years [-3], and 15-19 years [-4]). Martial arts intervention can provide a useful modality to decrease pain in

  20. Translatability score revisited: differentiation for distinct disease areas.

    Science.gov (United States)

    Wendler, Alexandra; Wehling, Martin

    2017-11-03

    Translational science supports successful transition of early biomedical research into human applications. In 2009 a translatability score to assess risk and identify strengths and weaknesses of a given project has been designed and successfully tested in case studies. The score elements, in particular the contributing weight factors, are heterogeneous for different disease areas; therefore, the score was individualized for six areas (cardiovascular, oncology, psychiatric, anti-viral, anti-bacterial/fungal and monogenetic diseases). FDA reviews and related literature were used for modifications of the score with emphasis on biomarkers, personalized medicine and animal models. 113 new medical entities approved by FDA from 2012 through 2016 were evaluated and metrics obtained for companion diagnostics and animal models as starting points for author-based individualization of the score. Most drugs approved in this period were related to oncology (46%), while the approvals were lowest for psychiatrics (4%). The evaluation of the FDA package inserts revealed that companion diagnostics play an important role in every field except psychiatrics. Further the analysis of the FDA reviews showed the weakness of animal models in psychiatrics and anti-virals, while useful animal models were present for all other fields. Consequently the scoring system was adapted to the different fields, resulting in increased weights for animal models, biomarker and personalized medicine in oncology. For psychiatrics the weights for animal models, biomarker and personalized medicine were decreased, while the weight for model compounds, clinical trials and surrogate or endpoint strategy were increased. For anti-viral drugs weights for in vitro data and personalized medicine were increased, while the weight for animal models was decreased. Further, for anti-bacterial/fungal drugs weights for animal models and personalized medicine were increased. Weights were increased for genetics and

  1. Translatability score revisited: differentiation for distinct disease areas

    Directory of Open Access Journals (Sweden)

    Alexandra Wendler

    2017-11-01

    Full Text Available Abstract Background Translational science supports successful transition of early biomedical research into human applications. In 2009 a translatability score to assess risk and identify strengths and weaknesses of a given project has been designed and successfully tested in case studies. The score elements, in particular the contributing weight factors, are heterogeneous for different disease areas; therefore, the score was individualized for six areas (cardiovascular, oncology, psychiatric, anti-viral, anti-bacterial/fungal and monogenetic diseases. Results FDA reviews and related literature were used for modifications of the score with emphasis on biomarkers, personalized medicine and animal models. 113 new medical entities approved by FDA from 2012 through 2016 were evaluated and metrics obtained for companion diagnostics and animal models as starting points for author-based individualization of the score. Most drugs approved in this period were related to oncology (46%, while the approvals were lowest for psychiatrics (4%. The evaluation of the FDA package inserts revealed that companion diagnostics play an important role in every field except psychiatrics. Further the analysis of the FDA reviews showed the weakness of animal models in psychiatrics and anti-virals, while useful animal models were present for all other fields. Consequently the scoring system was adapted to the different fields, resulting in increased weights for animal models, biomarker and personalized medicine in oncology. For psychiatrics the weights for animal models, biomarker and personalized medicine were decreased, while the weight for model compounds, clinical trials and surrogate or endpoint strategy were increased. For anti-viral drugs weights for in vitro data and personalized medicine were increased, while the weight for animal models was decreased. Further, for anti-bacterial/fungal drugs weights for animal models and personalized medicine were increased

  2. Gleason score 5 + 3 = 8 prostate cancer: much more like Gleason score 9?

    Science.gov (United States)

    Mahal, Brandon A; Muralidhar, Vinayak; Chen, Yu-Wei; Choueiri, Toni K; Hoffman, Karen E; Hu, Jim C; Sweeney, Christopher J; Yu, James B; Feng, Felix Y; Trinh, Quoc-Dien; Nguyen, Paul L

    2016-07-01

    To determine whether patients with Gleason score 5 + 3 = 8 prostate cancer have outcomes more similar to other patients with Gleason score 8 disease or to patients with Gleason score 9 disease. The Surveillance, Epidemiology and End Results (SEER) database was used to study 40 533 men diagnosed with N0M0 Gleason score 8 or 9 prostate cancer from 2004 to 2011. Using Gleason score 4 + 4 = 8 as the referent, Fine and Gray competing risks regression analyses modelled the association between Gleason score and prostate cancer-specific mortality (PCSM). The 5-year PCSM rates for patients with Gleason score 4 + 4 = 8, 3 + 5 = 8, 5 + 3 = 8, and 9 disease were 6.3%, 6.6%, 13.5%, and 13.9%, respectively (P Gleason score 5 + 3 = 8 or 9 disease had up to a two-fold increased risk of PCSM (adjusted hazard ratio [AHR] 1.89, 95% confidence interval [CI] 1.50-2.38, P Gleason score 4 + 4 = 8). There was no difference in PCSM between patients with Gleason score 5 + 3 = 8 vs 9 disease (P = 0.25). Gleason score 8 disease represents a heterogeneous entity with PCSM outcomes distinguishable by the primary Gleason pattern. The PCSM of Gleason score 3 + 5 = 8 and Gleason 4 + 4 = 8 disease are similar, but patients with Gleason score 5 + 3 = 8 have a risk of PCSM that is twice as high as other patients with Gleason score 8 disease and should be considered to have a similar poor prognosis as patients with Gleason score 9 disease. Such patients should be allowed onto trials seeking the highest-risk patients in which to test novel aggressive treatment strategies. © 2015 The Authors BJU International © 2015 BJU International Published by John Wiley & Sons Ltd.

  3. AN AUTOMATED SCORING APPROACH FOR ESSAY QUESTIONS

    OpenAIRE

    Alzahrani, Ahmed; Alzahrani, Abdulkareem; Alarfaj, Fawaz; Almohammadi, Khalid; Alrashidi, Malek

    2014-01-01

    Theautomated scoring or evaluation for written student responses have been, andare still a highly interesting topic for both education and natural languageprocessing, NLP, researchers alike. With the obvious motivation of thedifficulties teachers face when marking or correcting open essay questions; thedevelopment of automatic scoring methods have recently received much attention.In this paper, we developed and compared number of NLP techniques thataccomplish this task. The baseline for this ...

  4. Analysis of the Sensory Profile in Children with Smith-Magenis Syndrome

    Science.gov (United States)

    Hildenbrand, Hanna L.; Smith, Ann C. M.

    2012-01-01

    This study systematically assessed sensory processing in 34 children, aged 3-14 years, with Smith-Magenis syndrome (SMS) using the Sensory Profile Caregiver Questionnaire. Scores for the SMS cohort were significantly different from scores of the national sample of children with and without disabilities in all Sensory Profile categories and…

  5. Mitochondrial biogenesis related endurance genotype score and sports performance in athletes.

    Science.gov (United States)

    Eynon, Nir; Ruiz, Jonatan R; Meckel, Yoav; Morán, María; Lucia, Alejandro

    2011-01-01

    We determined the probability of individuals having the 'optimal' mitochondrial biogenesis related endurance polygenic profile, and compared the endurance polygenic profile of Israeli (Caucasian) endurance athletes (n = 74), power athletes (n = 81), and non-athletes (n = 240). We computed a mitochondrial biogenesis related 'endurance genotype score' (EGS, scoring from 0 to 100) from the accumulated combination of six polymorphisms in the PPARGC1A-NRF-TFAM pathway. Some of the variant alleles of the polymorphisms studied were so infrequent, that the probability of possessing an 'optimal' EGS (= 100) was 0% in the entire study population. However, the EGS was significantly higher (Pgenetic background for endurance sports is very low, in general endurance athletes have a polygenic profile that is more suitable for mitochondrial biogenesis. Copyright © 2010 Elsevier B.V. and Mitochondria Research Society. All rights reserved.

  6. Discrimination of the sensory quality of the Coffea arabica L. (cv. Yellow Bourbon) produced in different altitudes using decision trees obtained by the CHAID method.

    Science.gov (United States)

    Ramos, Mariana Figueira; Ribeiro, Diego Egídio; Cirillo, Marcelo Ângelo; Borém, Flávio Meira

    2016-08-01

    Knowledge of the sensory profile of coffee quality, associated with genetic and environmental factors, is of utmost importance for the international market, as well as for the productive sector. In this context, the goal of this study was to classify the quality of Coffea arabica L., cv. Yellow Bourbon, according to different scores obtained through sensory evaluations based on the Specialty Coffee Association of America protocol (SCAA), and by means of decision trees resulting from applying the CHAID method (chi-square automatic interaction detection). To that end, we used a database with the sensory characteristics of cv. Yellow Bourbon and the environmental characteristics of the Mantiqueira de Minas region, State of Minas Gerais, Brazil. The method used exhibited promising results regarding accuracy and success rates in order to discriminate coffee sensory quality as a function of the production environment. The results obtained clearly show the effect of the coffee growing environment on the Yellow Bourbon variety, resulting in notable sensory differences in the beverage. It was possible to discriminate cv. Yellow Bourbon coffee samples, the sensory evaluations of which resulted in scores of ≥88 points, which are associated with growing environments at altitudes of ≥1200 m. © 2015 Society of Chemical Industry. © 2015 Society of Chemical Industry.

  7. Pharmacophore-based similarity scoring for DOCK.

    Science.gov (United States)

    Jiang, Lingling; Rizzo, Robert C

    2015-01-22

    Pharmacophore modeling incorporates geometric and chemical features of known inhibitors and/or targeted binding sites to rationally identify and design new drug leads. In this study, we have encoded a three-dimensional pharmacophore matching similarity (FMS) scoring function into the structure-based design program DOCK. Validation and characterization of the method are presented through pose reproduction, crossdocking, and enrichment studies. When used alone, FMS scoring dramatically improves pose reproduction success to 93.5% (∼20% increase) and reduces sampling failures to 3.7% (∼6% drop) compared to the standard energy score (SGE) across 1043 protein-ligand complexes. The combined FMS+SGE function further improves success to 98.3%. Crossdocking experiments using FMS and FMS+SGE scoring, for six diverse protein families, similarly showed improvements in success, provided proper pharmacophore references are employed. For enrichment, incorporating pharmacophores during sampling and scoring, in most cases, also yield improved outcomes when docking and rank-ordering libraries of known actives and decoys to 15 systems. Retrospective analyses of virtual screenings to three clinical drug targets (EGFR, IGF-1R, and HIVgp41) using X-ray structures of known inhibitors as pharmacophore references are also reported, including a customized FMS scoring protocol to bias on selected regions in the reference. Overall, the results and fundamental insights gained from this study should benefit the docking community in general, particularly researchers using the new FMS method to guide computational drug discovery with DOCK.

  8. Obtaining superfine ethanol in a Cuban distillery

    Directory of Open Access Journals (Sweden)

    Yailet Albernas Carvajal

    2012-09-01

    Full Text Available This paper describes obtaining superfine ethanol in a Cuban distillery from molasses as base raw material. The operational characteristics of the main stages for obtaining superfine alcohol have been described, emphasising alcohol fermentation due to its complexity in achieving process continuity; a Gantt chart led to determining a 31-hour process time and 5-hour cycle time. The influence of fermentation yield on process profitability was determined through mass and energy balances, demonstrating that a 4ºGL degree of alcohol was feasible. The main water-consuming elements were also determined (98% in molasses dilution as well as steam consumption (91% during distillation. A preliminary analysis was made of the opportunities provided by material and energy integration, mainly for distillation, contributing towards a positive environmental impact.

  9. Processing of hydroxyapatite obtained by combustion synthesis

    Directory of Open Access Journals (Sweden)

    M. Canillas

    2017-09-01

    Full Text Available One of the reasons of implants failure are the stress forces appearing in the material–tissue interface due to the differences between their mechanical properties. For this reason, similar mechanical properties to the surrounding tissue are desirable. The synthesis of hydroxyapatite by solution combustion method and its processing have been studied in order to obtain fully dense ceramic bodies with improved mechanical strength. Combustion synthesis provides nanostructured powders characterized by a high surface area to facilitate the following sintering. Moreover, synthesis was conducted in aqueous and oxidizing media. Oxidizing media improve homogenization and increase the energy released during combustion. It gives rise to particles whose morphology and size suggest lower surface energies compared with aqueous media. The obtained powders were sintered by using a controlled sintering rate schedule. Lower surfaces energies minimize the shrinkage during sintering and relative densities measurements and diametral compression test confirm improved densification and consequently mechanical properties.

  10. Voice activity and participation profile - VAPP administered in two different scales of response.

    Science.gov (United States)

    Pires, Marcela Dutra Esteves; Oliveira, Gisele; Behlau, Mara

    2011-09-01

    The purpose of this study was to compare two types of rating scales using the Voice Activity and Participation Profile (VAPP) self-assessment questionnaire, in order to check their influence on the results obtained by the same instrument. Participants were 32 individuals with vocal complaints of both genders, with ages between 15 and 58 years. All subjects answered the vocal self-assessment questionnaire VAPP using with two different rating scales, randomly presented: an 11-point numerical scale (NS) and a 10-cm long (or 100 points) visual analogue scale (VAS). Response time was registered and there was a two-week interval between applications. At the end of the task, participants were asked about the difficulties found in the task to answer each rating scale version, and also to indicate their preference. The mean VAPP scores were similar in both scales. Differences were found only in partial scores, referring to Activity Limitation and Effects on Emotion, with higher mean score in the numerical scale (p=0.008), however with no clinical impact. The order in which the scales were answered did not affect the results obtained, except for the aspect Effects on Social Communication, which presented lower scores with the visual analogue scale in the group of subjects that answered the numeric scale first (p=0.049). Finally, most participants answered faster to the questionnaire when using the numerical scale (p=0.003). The scores obtained in the VAPP by the two different rating scales were similar. The questionnaire with the numeric scale takes less time to be answered, which may be useful for clinical practice.

  11. Finger Tapping Clinimetric Score Prediction in Parkinson's Disease Using Low-Cost Accelerometers

    Directory of Open Access Journals (Sweden)

    Julien Stamatakis

    2013-01-01

    algorithm were used to identify the most relevant features in the prediction of MDS-UPDRS FT scores, given by 3 specialists in movement disorders (SMDs. The Goodman-Kruskal Gamma index obtained (0.961, depicting the predictive performance of the model, is similar to those obtained between the individual scores given by the SMD (0.870 to 0.970. The automatic prediction of MDS-UPDRS scores using the proposed system may be valuable in clinical trials designed to evaluate and modify motor disability in PD patients.

  12. Comparing methods for scoring personality disorder types using maladaptive traits in DSM-5.

    Science.gov (United States)

    Samuel, Douglas B; Hopwood, Christopher J; Krueger, Robert F; Thomas, Katherine M; Ruggero, Camilo J

    2013-06-01

    The DSM-5 (Diagnostic and Statistical Manual of Mental Disorders, 5th ed.) Section III will include an alternative hybrid system for the diagnosis of personality disorder (PD). This alternative system defines PD types partly through specific combinations of maladaptive traits, rather than by using a set of polythetic diagnostic criteria. The current report utilizes a large sample of undergraduates (n = 1,159) to examine three dimensional methods for comparing an individual's trait profile to each PD type. We found that the sum of an individual's scores on the assigned traits obtained large convergent correlations (Mdn r =.61) and best reproduced the patterns of PD discriminant correlations observed within the DSM-IV measure. We also tested the DSM-5 Section III model algorithms and compared them with different thresholds for assigning categorical diagnoses. Frequency rates using the algorithms were greatly reduced, whereas requiring half of the assigned traits produced rates that more closely approximated current prevalence estimates. Our research suggests that DSM-5 Section III trait model can reproduce the DSM-IV-TR PD constructs and identifies effective methods of doing so.

  13. [Cleft lip, alveolar and palate sequelae. Proposal of new alveolar score by the Alveolar Cleft Score (ACS) classification].

    Science.gov (United States)

    Molé, C; Simon, E

    2015-06-01

    The management of cleft lip, alveolar and palate sequelae remains problematic today. To optimize it, we tried to establish a new clinical index for diagnostic and prognostic purposes. Seven tissue indicators, that we consider to be important in the management of alveolar sequelae, are listed by assigning them individual scores. The final score, obtained by adding together the individual scores, can take a low, high or maximum value. We propose a new classification (ACS: Alveolar Cleft Score) that guides the therapeutic team to a prognosis approach, in terms of the recommended surgical and prosthetic reconstruction, the type of medical care required, and the preventive and supportive therapy to establish. Current studies are often only based on a standard radiological evaluation of the alveolar bone height at the cleft site. However, the gingival, the osseous and the cellular areas bordering the alveolar cleft sequelae induce many clinical parameters, which should be reflected in the morphological diagnosis, to better direct the surgical indications and the future prosthetic requirements, and to best maintain successful long term aesthetic and functional results. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

  14. Introducing the SKIN score: a validated scoring system to assess severity of mastectomy skin flap necrosis.

    Science.gov (United States)

    Lemaine, Valerie; Hoskin, Tanya L; Farley, David R; Grant, Clive S; Boughey, Judy C; Torstenson, Tiffany A; Jacobson, Steven R; Jakub, James W; Degnim, Amy C

    2015-09-01

    With increasing use of immediate breast reconstruction (IBR), mastectomy skin flap necrosis (MSFN) is a clinical problem that deserves further study. We propose a validated scoring system to discriminate MSFN severity and standardize its assessment. Women who underwent skin-sparing (SSM) or nipple-sparing mastectomy (NSM) and IBR from November 2009 to October 2010 were studied retrospectively. A workgroup of breast and plastic surgeons scored postoperative photographs using the skin ischemia necrosis (SKIN) score to assess depth and surface area of MSFN. We evaluated correlation of the SKIN score with reoperation for MSFN and its reproducibility in an external sample of surgeons. We identified 106 subjects (175 operated breasts: 103 SSM, 72 NSM) who had ≥1 postoperative photograph within 60 days. SKIN scores correlated strongly with need for reoperation for MSFN, with an AUC of 0.96 for SSM and 0.89 for NSM. External scores agreed well with the gold standard scores for the breast mound photographs with weighted kappa values of 0.82 (depth), 0.56 (surface area), and 0.79 (composite score). The agreement was similar for the nipple-areolar complex photographs: 0.75 (depth), 0.63 (surface area), and 0.79 (composite score). A simple scoring system to assess the severity of MSFN is proposed, incorporating both depth and surface area of MSFN. The SKIN score correlates strongly with the need for reoperation to manage MSFN and is reproducible among breast and plastic surgeons.

  15. FitSearch: a robust way to interpret a yeast fitness profile in terms of drug's mode-of-action.

    Science.gov (United States)

    Lee, Minho; Han, Sangjo; Chang, Hyeshik; Kwak, Youn-Sig; Weller, David M; Kim, Dongsup

    2013-01-01

    Yeast deletion-mutant collections have been successfully used to infer the mode-of-action of drugs especially by profiling chemical-genetic and genetic-genetic interactions on a genome-wide scale. Although tens of thousands of those profiles are publicly available, a lack of an accurate method for mining such data has been a major bottleneck for more widespread use of these useful resources. For general usage of those public resources, we designed FitRankDB as a general repository of fitness profiles, and developed a new search algorithm, FitSearch, for identifying the profiles that have a high similarity score with statistical significance for a given fitness profile. We demonstrated that our new repository and algorithm are highly beneficial to researchers who attempting to make hypotheses based on unknown modes-of-action of bioactive compounds, regardless of the types of experiments that have been performed using yeast deletion-mutant collection in various types of different measurement platforms, especially non-chip-based platforms. We showed that our new database and algorithm are useful when attempting to construct a hypothesis regarding the unknown function of a bioactive compound through small-scale experiments with a yeast deletion collection in a platform independent manner. The FitRankDB and FitSearch enhance the ease of searching public yeast fitness profiles and obtaining insights into unknown mechanisms of action of drugs. FitSearch is freely available at http://fitsearch.kaist.ac.kr.

  16. Genetic evaluation of elbow scores and the relationship with hip scores in UK Labrador retrievers.

    Science.gov (United States)

    Lewis, T W; Ilska, J J; Blott, S C; Woolliams, J A

    2011-08-01

    A linear mixed model analysis of elbow and hip score data from UK Labrador retrievers was used to estimate the heritability of elbow score (0.16-0.19) and to determine a moderate and beneficial genetic correlation with hip score (0.40). A small improvement in the genetic trend of elbow score was observed during the years 2000-2008, equivalent to avoiding only the worst 3-4% of scored dogs for breeding, but close to what may have been anticipated if the current British Veterinary Association-approved guidelines were followed. Calculations suggested that a correlated response to indirect selection on hip score may elicit a greater response than direct selection on elbow score and that the genetic trend in elbow score may be explained as a consequence of the stronger selection pressure that has been placed on hip score. Increases in the accuracy of estimated breeding values for elbow score of 4-7% for dogs with elbow data only and 7-11% for dogs with both hip and elbow score were observed from bivariate analysis of elbow and hip data. A selection index confirmed the benefits of bivariate analysis of elbow and hip score data by identifying increases in accuracy (directly related to the response to selection) of 14% from the use of optimum coefficients compared to use of hip data only. The quantified genetic correlation means that hip score effectively acts as a 'secondary indicator' of elbow score in this breed and the preponderance of hip data means that it acts as a major source of information that may be used to improve the accuracy of estimates of genetic risk for elbow dysplasia. Copyright © 2011 Elsevier Ltd. All rights reserved.

  17. Nasalance score variation in normal adult Japanese speakers of Mid-West Japanese dialect.

    Science.gov (United States)

    Tachimura, T; Mori, C; Hirata, S I; Wada, T

    2000-09-01

    The aims of this study were to examine nasalance score variation for normal adult Japanese speakers of Mid-West dialect and the gender difference in average mean nasalance score. Nasalance scores were obtained using a nasometer model 6200. The sample stimulus "Kitsutsuki passage," constructed of four sentences containing no Japanese nasal sounds, was used three times by each subject. One hundred normal adult speakers (50 women and 50 men) of Japanese served as subjects. The subjects ranged in age from 19 to 35 years of age (24.0 +/- 3.2). A mean nasalance score as well as an overall average nasalance value across speakers was calculated for each subject. The average mean nasalance scores between men and women were compared. The average mean nasalance score for the normal Japanese speakers was 9.1% (+/- 3.9). There was no statistically significant sex difference (p nasometer.

  18. Neuropsychological test scores, academic performance, and developmental disorders in Spanish-speaking children.

    Science.gov (United States)

    Rosselli, M; Ardila, A; Bateman, J R; Guzmán, M

    2001-01-01

    Limited information is currently available about performance of Spanish-speaking children on different neuropsychological tests. This study was designed to (a) analyze the effects of age and sex on different neuropsychological test scores of a randomly selected sample of Spanish-speaking children, (b) analyze the value of neuropsychological test scores for predicting school performance, and (c) describe the neuropsychological profile of Spanish-speaking children with learning disabilities (LD). Two hundred ninety (141 boys, 149 girls) 6- to 11-year-old children were selected from a school in Bogotá, Colombia. Three age groups were distinguished: 6- to 7-, 8- to 9-, and 10- to 11-year-olds. Performance was measured utilizing the following neuropsychological tests: Seashore Rhythm Test, Finger Tapping Test (FTT), Grooved Pegboard Test, Children's Category Test (CCT), California Verbal Learning Test-Children's Version (CVLT-C), Benton Visual Retention Test (BVRT), and Bateria Woodcock Psicoeducativa en Español (Woodcock, 1982). Normative scores were calculated. Age effect was significant for most of the test scores. A significant sex effect was observed for 3 test scores. Intercorrelations were performed between neuropsychological test scores and academic areas (science, mathematics, Spanish, social studies, and music). In a post hoc analysis, children presenting very low scores on the reading, writing, and arithmetic achievement scales of the Woodcock battery were identified in the sample, and their neuropsychological test scores were compared with a matched normal group. Finally, a comparison was made between Colombian and American norms.

  19. Multiple scaling behaviour and nonlinear traits in music scores.

    Science.gov (United States)

    González-Espinoza, Alfredo; Larralde, Hernán; Martínez-Mekler, Gustavo; Müller, Markus

    2017-12-01

    We present a statistical analysis of music scores from different composers using detrended fluctuation analysis (DFA). We find different fluctuation profiles that correspond to distinct autocorrelation structures of the musical pieces. Further, we reveal evidence for the presence of nonlinear autocorrelations by estimating the DFA of the magnitude series, a result validated by a corresponding study of appropriate surrogate data. The amount and the character of nonlinear correlations vary from one composer to another. Finally, we performed a simple experiment in order to evaluate the pleasantness of the musical surrogate pieces in comparison with the original music and find that nonlinear correlations could play an important role in the aesthetic perception of a musical piece.

  20. Multiple scaling behaviour and nonlinear traits in music scores

    Science.gov (United States)

    González-Espinoza, Alfredo; Larralde, Hernán; Martínez-Mekler, Gustavo; Müller, Markus

    2017-12-01

    We present a statistical analysis of music scores from different composers using detrended fluctuation analysis (DFA). We find different fluctuation profiles that correspond to distinct autocorrelation structures of the musical pieces. Further, we reveal evidence for the presence of nonlinear autocorrelations by estimating the DFA of the magnitude series, a result validated by a corresponding study of appropriate surrogate data. The amount and the character of nonlinear correlations vary from one composer to another. Finally, we performed a simple experiment in order to evaluate the pleasantness of the musical surrogate pieces in comparison with the original music and find that nonlinear correlations could play an important role in the aesthetic perception of a musical piece.

  1. Characterization of Wastewaters obtained from Hatay Tanneries

    Directory of Open Access Journals (Sweden)

    Şana Sungur

    2017-06-01

    Full Text Available The leather tanning industry is one of the most significant pollutants in terms of both conventional and toxic parameters. On the other hand, leather industry has an important economic role both in Turkey and in the World. In this study, wastewater samples were taken from 15 different tanneries in the Hatay Region. Wastewaters obtained from liming process and chromium tanning process was analyzed. Sulfide, chromium (III, chromium (VI, oil and grease, total suspended solids (TSS, organic matters, biochemical oxygen demand (BOD, chemical oxygen demand (COD, pH and alkalinity were determined according to Turkish Standard Methods. The determined averages values belong to wastewaters obtained from liming process were as following: pH 11.71; COD 16821 mg L-1; BOD 4357 mg L-1; TSS 39023 mg L-1; oil and grease 364 mg L-1; S-2 concentration 802 mg L-1; alkalinity 2115 mg L-1. The determined averages values belong to wastewaters obtained from chromium tanning process were also as following: pH 4.23; COD 6740 mg L-1; BOD 377 mg L-1; Cr+3 concentrations 372 mg L-1; Cr+6 concentrations 127 mg L-1; TSS 14553 mg L-1; oil and grease 343 mg L-1. The results of all analyzes were higher than wastewater discharge standards. As a result, it’s necessary to use more effective treatments in order to reduce the negative impacts of leather tanning industry that affect environment, natural water resources and at last human health and welfare.

  2. Propensity for obtaining alcohol through shoulder tapping.

    Science.gov (United States)

    Toomey, Traci L; Fabian, Lindsey E A; Erickson, Darin J; Lenk, Kathleen M

    2007-07-01

    Underage youth often obtain alcohol from adults who illegally provide the alcohol. One method for obtaining alcohol from adults is shoulder tapping, where youth approach an adult outside an alcohol establishment and ask the adult to purchase alcohol for them. The goal of this study was to assess what percentage of the general and youth-targeted adult population approached outside of a convenience/liquor store will agree to purchase and then provide alcohol to individuals who appear under age 21. We conducted 2 waves of pseudo-underage shoulder tap request attempts, using requesters who were age 21 or older but appeared 18 to 20 years old. In both waves, requests were conducted at randomly selected liquor and convenience stores, requesters explained that the reason they were asking the adult was because they did not have their identification with them, and requesters asked the adults to purchase a 6-pack of beer. During wave 1, we conducted 102 attempts, with the requester approaching the first adult entering the store alone. During wave 2, we conducted 102 attempts where the requester approached the first casually dressed male entering the store alone who appeared to be 21 to 30 years old. During wave 1, 8% of the general sample of approached adults provided alcohol to the pseudo-underage requesters. The odds of adults providing alcohol in urban areas were 9.4 times greater than in suburban areas. During wave 2, 19% of the approached young men provided alcohol to the requesters. No requester, request attempt, establishment, or community characteristics were associated with request attempt outcomes during wave 2. A small percentage of the general population of adults will agree to provide alcohol to underage youth when approached outside an alcohol establishment. The likelihood of underage youth obtaining alcohol through shoulder tapping increases substantially if the youth approach young men.

  3. Unraveling Motivational Profiles of Health Care Professionals for Continuing Education: The Example of Pharmacists in the Netherlands.

    Science.gov (United States)

    Tjin A Tsoi, Sharon L N M; de Boer, Anthonius; Croiset, Gerda; Koster, Andries S; Kusurkar, Rashmi A

    2016-01-01

    Continuing education (CE) can support health care professionals in maintaining and developing their knowledge and competencies. Although lack of motivation is one of the most important barriers of pharmacists' participation in CE, we know little about the quality or the quantity of motivation. We used the self-determination theory, which describes autonomous motivation (AM) as originating from within an individual and controlled motivation (CM) as originating from external factors, as a framework for this study. Our aim was to obtain insight into the quality and quantity of pharmacists' motivation for CE. The scores of 425 pharmacists on Academic Motivation Scale were subjected to K-means cluster analysis to generate motivational profiles. We unraveled four motivational profiles: (1) good quality with high AM/low CM, (2) high quantity with high AM/high CM, (3) poor quality with low AM/high CM, and (4) low quantity with low AM/low CM. Female pharmacists, pharmacists working in a hospital pharmacy, pharmacists working for more than 10 years, and pharmacists not in training were highly represented in the good-quality profile. Pharmacists working in a community pharmacy, pharmacists working for less than 10 years, and pharmacists in training were highly represented in the high-quantity profile. Male pharmacists were more or less equally distributed over the four profiles. The highest percentage of pharmacy owners was shown in the low-quantity profile, and the highest percentage of the nonowners was shown in the good-quality profile. Pharmacists exhibit different motivational profiles, which are associated with their background characteristics, such as gender, ownership of business, practice setting, and current training. Motivational profiles could be used to tailor CE courses for pharmacists.

  4. Comparison of ionospheric characteristic parameters obtained by ...

    Indian Academy of Sciences (India)

    This paper presents a comparison of ionospheric characteristic parameters obtained by a GPS networkand three ionosondes at Mohe (122.4^◦E, 53.5^◦N, dip angle 70.983^◦N), Zuolingzhen (114.6^◦E, 30.5^◦N, dipangle 46.350^◦N), and Fuke (109.1^◦E, 19.5^◦N, dip angle 27.083^◦N) located in China with an IRI model inthe ...

  5. Modeling of Changing Electrode Profiles

    Energy Technology Data Exchange (ETDEWEB)

    Prentice, Geoffrey Allen [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Materials and Molecular Research Division; Univ. of California, Berkeley, CA (United States). Dept. of Chemical Engineering

    1980-12-01

    A model for simulating the transient behavior of solid electrodes undergoing deposition or dissolution has been developed. The model accounts for ohmic drop, charge transfer overpotential, and mass transport limitations. The finite difference method, coupled with successive overrelaxation, was used as the basis of the solution technique. An algorithm was devised to overcome the computational instabilities associated with the calculations of the secondary and tertiary current distributions. Simulations were performed on several model electrode profiles: the sinusoid, the rounded corner, and the notch. Quantitative copper deposition data were obtained in a contoured rotating cylinder system, Sinusoidal cross-sections, machined on stainless steel cylinders, were used as model geometries, Kinetic parameters for use in the simulation were determined from polarization curves obtained on copper rotating cylinders, These parameters, along with other physical property and geometric data, were incorporated in simulations of growing sinusoidal profiles. The copper distributions on the sinusoidal cross-sections were measured and found to compare favorably with the simulated results. At low Wagner numbers the formation of a slight depression at the profile peak was predicted by the simulation and observed on the profile. At higher Wagner numbers, the simulated and experimental results showed that the formation of a depression was suppressed. This phenomenon was shown to result from the competition between ohmic drop and electrode curvature.

  6. An equilibrium profile model for tidal environments

    Directory of Open Access Journals (Sweden)

    A. M. Bernabeu

    2002-12-01

    Full Text Available During a full tidal cycle, the beach profile is exposed to continuously changing hydrodynamical conditions. Consequently, the profile evolves constantly to adapt to these changes. The equilibrium condition on tidal beaches is defined in terms of the relative occurrence of swash, surf zone and shoaling processes. We have assumed that the tidal beach profile is in equilibrium when the net sediment transport along a tidal cycle is zero. In this model the contribution of swash is considered negligible. A simple and easy-to-apply equilibrium profile formulation is proposed. This model is based on the assumption that surf zone processes dominate the profile morphology wherever wave breaking occurs during the tidal cycle. The obtained equilibrium profile is valid from the high tide level to the breaker point at low tide level. The tidal influence on the profile morphology is the lengthening of the surf profile. The higher the tidal range, the longer the surf profile. The model was tested against field and laboratory data, showing reasonable predictions of measured beach profiles.

  7. A bistatic sodar for precision wind profiling in complex terrain

    DEFF Research Database (Denmark)

    Bradley, Stuart; Hünerbein, Sabine Von; Mikkelsen, Torben

    2012-01-01

    A new ground-based wind profiling technology-a scanned bistatic sodar-is described. The motivation for this design is to obtain a "mastlike"wind vector profile in a single atmospheric column extending from the ground to heights of more than 200 m. The need for this columnar profiling arises from...

  8. RISK FACTOR DIAGNOSTIC SCORE IN DIABETIC FOOT

    Directory of Open Access Journals (Sweden)

    Mohamed Shameem P. M

    2016-09-01

    Full Text Available INTRODUCTION Diabetic foot ulcers vary in their clinical presentation and nature of severity and therefore create a challenging problem to the treating surgeon regarding the prediction of the clinical course and the end result of the treatment. Clinical studies have shown that there are certain risk factors for the progression of foot ulcers in diabetics and it may therefore be possible to predict the course of an ulcer foot at presentation itself, thus instituting proper therapy without delay. Spoken otherwise clinical scoring may tell that this particular ulcer is having highest chance of amputation, then one may be able to take an early decision for the same and avoid the septic complications, inconvenience to the patient, long hospital stay and cost of treatments. AIM OF THE STUDY Aim of the study is to evaluate the above-mentioned scoring system in predicting the course the diabetic foot ulcers. MATERIALS AND METHODS 50 patients with Diabetic Foot attending the OPD of Department of Surgery of Government Hospital attached to Calicut Medical College are included in the present study. After thorough history taking and clinical examination, six risk factors like Age, pedal vessels, renal function, neuropathy, radiological findings and ulcers were observed in the patients by giving certain scoring points to each of them. The total number of points scored by the patients at the time of admission or OPD treatment was correlated with the final outcome in these patients, whether leading to amputation or conservative management. All the data was analysed using standard statistical methods. OBSERVATIONS AND RESULTS There were 12 females and 38 males with a female to male ratio 1:3.1. All were aged above 30 years. Twenty-four (48% of them were between 30-60 years and twenty six (52% were above 60 years. 10 patients were treated conservatively with risk score range: 10 to 35. Six had single toe loss with risk score: 25 to 35. Six had multiple toe loss

  9. Comparison of Myelodysplastic Syndrome Prognostic Scoring Systems

    Science.gov (United States)

    Bektaş, Özlen; Üner, Ayşegül; Eliaçık, Eylem; Uz, Burak; Işık, Ayşe; Etgül, Sezgin; Bozkurt, Süreyya; Haznedaroğlu, İbrahim Celalettin; Göker, Hakan; Sayınalp, Nilgün; Aksu, Salih; Demiroğlu, Haluk; Özcebe, Osman İlhami; Büyükaşık, Yahya

    2016-01-01

    Objective: Myelodysplastic syndrome (MDS) is a clonal hematopoietic stem cell disease. Patients are at risk of developing cytopenias or progression to acute myeloid leukemia. Different classifications and prognostic scoring systems have been developed. The aim of this study was to compare the different prognostic scoring systems. Materials and Methods: One hundred and one patients who were diagnosed with primary MDS in 2003-2011 in a tertiary care university hospital’s hematology department were included in the study. Results: As the International Prognostic Scoring System (IPSS), World Health Organization Classification-Based Prognostic Scoring System (WPSS), MD Anderson Prognostic Scoring System (MPSS), and revised IPSS (IPSS-R) risk categories increased, leukemia-free survival and overall survival decreased (p<0.001). When the IPSS, WPSS, MPSS, and IPSS-R prognostic systems were compared by Cox regression analysis, the WPSS was the best in predicting leukemia-free survival (p<0.001), and the WPSS (p<0.001) and IPSS-R (p=0.037) were better in predicting overall survival. Conclusion: All 4 prognostic systems were successful in predicting overall survival and leukemia-free survival (p<0.001). The WPSS was found to be the best predictor for leukemia-free survival, while the WPSS and IPSS-R were found to be the best predictors for overall survival. PMID:26376664

  10. Dynamic TIMI risk score for STEMI.

    Science.gov (United States)

    Amin, Sameer T; Morrow, David A; Braunwald, Eugene; Sloan, Sarah; Contant, Charles; Murphy, Sabina; Antman, Elliott M

    2013-01-29

    Although there are multiple methods of risk stratification for ST-elevation myocardial infarction (STEMI), this study presents a prospectively validated method for reclassification of patients based on in-hospital events. A dynamic risk score provides an initial risk stratification and reassessment at discharge. The dynamic TIMI risk score for STEMI was derived in ExTRACT-TIMI 25 and validated in TRITON-TIMI 38. Baseline variables were from the original TIMI risk score for STEMI. New variables were major clinical events occurring during the index hospitalization. Each variable was tested individually in a univariate Cox proportional hazards regression. Variables with PTIMI risk score. In the validation database, the C-statistic was 0.81, with a NRI of 0.35 (P=0.01). This score is a prospectively derived, validated means of estimating 1-year mortality of STEMI at hospital discharge and can serve as a clinically useful tool. By incorporating events during the index hospitalization, it can better define risk and help to guide treatment decisions.

  11. [Overview of regulatory aspects guiding tablet scoring].

    Science.gov (United States)

    Teixeira, Maíra Teles; Sá-Barreto, Lívia Cristina Lira; Silva, Dayde Lane Mendonça; Cunha-Filho, Marcílio Sergio Soares

    2016-06-01

    Tablet scoring is a controversial but common practice used to adjust doses, facilitate drug intake, or lower the cost of drug treatment, especially in children and the elderly. The risks of tablet scoring are mainly related to inaccuracies in the resulting dose and stability problems. The aim of this article is to provide an overview of worldwide guidelines regarding tablet scoring. We found that regulatory health agencies in Mercosur countries as well as other South American countries do not have published standards addressing tablet splitting. Among the surveyed health agencies, the Food and Drug Administration (FDA) in the United States is the only one to present standards, ranging from splitting instructions to regulation of the manufacturing process. The concept of functional scoring implemented by the FDA has introduced some level of guarantee as to the ability of tablets to be split. In conclusion, technical and scientific bases are still insufficient to guide health rules on this subject, making the decision on scoring, in certain situations, random and highly risky to public health. The need for more detailed regulation is vital to ensure the safety of tablet medications.

  12. Disease severity scoring systems in dermatology

    Directory of Open Access Journals (Sweden)

    Cemal Bilaç

    2016-06-01

    Full Text Available Scoring systems have been developed to interpret the disease severity objectively by evaluating the parameters of the disease. Body surface area, visual analogue scale, and physician global assessment are the most frequently used scoring systems for evaluating the clinical severity of the dermatological diseases. Apart from these scoring systems, many specific scoring systems for many dermatological diseases, including acne (acne vulgaris, acne scars, alopecia (androgenetic alopecia, tractional alopecia, bullous diseases (autoimmune bullous diseases, toxic epidermal necrolysis, dermatitis (atopic dermatitis, contact dermatitis, dyshidrotic eczema, hidradenitis suppurativa, hirsutismus, connective tissue diseases (dermatomyositis, skin involvement of systemic lupus erythematosus (LE, discoid LE, scleroderma, lichen planoplaris, mastocytosis, melanocytic lesions, melasma, onychomycosis, oral lichen planus, pityriasis rosea, psoriasis (psoriasis vulgaris, psoriatic arthritis, nail psoriasis, sarcoidosis, urticaria, and vitiligo, have also been developed. Disease severity scoring methods are ever more extensively used in the field of dermatology for clinical practice to form an opinion about the prognosis by determining the disease severity; to decide on the most suitable treatment modality for the patient; to evaluate the efficacy of the applied medication; and to compare the efficiency of different treatment methods in clinical studies.

  13. Gambling scores for earthquake predictions and forecasts

    Science.gov (United States)

    Zhuang, Jiancang

    2010-04-01

    This paper presents a new method, namely the gambling score, for scoring the performance earthquake forecasts or predictions. Unlike most other scoring procedures that require a regular scheme of forecast and treat each earthquake equally, regardless their magnitude, this new scoring method compensates the risk that the forecaster has taken. Starting with a certain number of reputation points, once a forecaster makes a prediction or forecast, he is assumed to have betted some points of his reputation. The reference model, which plays the role of the house, determines how many reputation points the forecaster can gain if he succeeds, according to a fair rule, and also takes away the reputation points betted by the forecaster if he loses. This method is also extended to the continuous case of point process models, where the reputation points betted by the forecaster become a continuous mass on the space-time-magnitude range of interest. We also calculate the upper bound of the gambling score when the true model is a renewal process, the stress release model or the ETAS model and when the reference model is the Poisson model.

  14. Comparison of Myelodysplastic Syndrome Prognostic Scoring Systems

    Directory of Open Access Journals (Sweden)

    Özlen Bektaş

    2016-05-01

    Full Text Available Objective: Myelodysplastic syndrome (MDS is a clonal hematopoietic stem cell disease. Patients are at risk of developing cytopenias or progression to acute myeloid leukemia. Different classifications and prognostic scoring systems have been developed. The aim of this study was to compare the different prognostic scoring systems. Materials and Methods: One hundred and one patients who were diagnosed with primary MDS in 2003-2011 in a tertiary care university hospital’s hematology department were included in the study. Results: As the International Prognostic Scoring System (IPSS, World Health Organization Classification-Based Prognostic Scoring System (WPSS, MD Anderson Prognostic Scoring System (MPSS, and revised IPSS (IPSS-R risk categories increased, leukemia-free survival and overall survival decreased (p<0.001. When the IPSS, WPSS, MPSS, and IPSS-R prognostic systems were compared by Cox regression analysis, the WPSS was the best in predicting leukemia-free survival (p<0.001, and the WPSS (p<0.001 and IPSS-R (p=0.037 were better in predicting overall survival. Conclusion: All 4 prognostic systems were successful in predicting overall survival and leukemia-free survival (p<0.001. The WPSS was found to be the best predictor for leukemia-free survival, while the WPSS and IPSS-R were found to be the best predictors for overall survival.

  15. Experimental methodology for obtaining sound absorption coefficients

    Directory of Open Access Journals (Sweden)

    Carlos A. Macía M

    2011-07-01

    Full Text Available Objective: the authors propose a new methodology for estimating sound absorption coefficients using genetic algorithms. Methodology: sound waves are generated and conducted along a rectangular silencer. The waves are then attenuated by the absorbing material covering the silencer’s walls. The attenuated sound pressure level is used in a genetic algorithm-based search to find the parameters of the proposed attenuation expressions that include geometric factors, the wavelength and the absorption coefficient. Results: a variety of adjusted mathematical models were found that make it possible to estimate the absorption coefficients based on the characteristics of a rectangular silencer used for measuring the attenuation of the noise that passes through it. Conclusions: this methodology makes it possible to obtain the absorption coefficients of new materials in a cheap and simple manner. Although these coefficients might be slightly different from those obtained through other methodologies, they provide solutions within the engineering accuracy ranges that are used for designing noise control systems.

  16. OBTAINING AND CHARACTERISTIC OF CURCUMIN LIPOSOMAL FORM

    Directory of Open Access Journals (Sweden)

    Shulga S. M.

    2014-10-01

    Full Text Available Creation of liposomal forms of curcumin (diferuloilmetane was investegated in the work. The methods of preparation and determination of the obtained liposomes sizes and percentage of curcumin in liposomes are given. Soybean phospholipids, egg yolk phospholipids and sunflower phospholipids were selected for preparation of “empty” liposomes and liposomes loaded curcumin: C-SPC-L (curcumin encapsulated in SPC liposomes, C-EPC-L (curcumin encapsulated in EPC liposomes and C-SFPC-L (curcumin encapsulated in liposomes SFPC. Physical properties of different liposomes such as average size (Dl and encapsulation efficiency (EE were studed. Using photon correlation spectroscopy, the average size of three types of curcumin-loaded liposomes were found as Dl = 111 ± 3 nm for C-SPC-L, Dl = 98 ± 5 nm for C-EPC-L and Dl = 109 ± 5 nm for C-SFPC-L. Encapsulation efficiency showed the following values: EEC-SPC-L = 83 ± 4%, EEC-EPC-L = 82 ± 3%, and EEC-SFPC-L = 85 ± 4%. We determined that by using the methods of freezing and thawing or sonication it was possible to isolate liposomes sized in the range 100– 120 nm. Upon that the obtained liposomal form of curcumin was stable and freeze-thaw method was optimal for liposomal form and provides a relatively high level (more than 80% of curcumin inclusion.

  17. Alcoholic Beverages Obtained from Black Mulberry

    Directory of Open Access Journals (Sweden)

    Jacinto Darias-Martín

    2003-01-01

    Full Text Available Black mulberry (Morus nigra is a fruit not known only for its nutritional qualities and its flavour, but also for its traditional use in natural medicine as it has a high content of active therapeutic compounds. However, this fruit is not widely produced in Spain but some trees are still found growing in the Canary Islands, particularly on the edges of the ravine. The inhabitants of these islands (Tenerife, La Gomera, La Palma, El Hierro and Lanzarote collect the fruit and prepare homemade beverages for medicinal purposes. Numerous authors have reported that type II diabetes mellitus can be controlled by taking a mixture containing black mulberry and water. Apart from that, this fruit has been used for the treatment of mouth, tongue and throat inflammations. In this study we present some characteristics of black mulberry juice (TSS, pH, titratable acidity, citric acid, lactic acid, polyphenols, anthocyanins, the potassium etc. and alcoholic beverages (alcoholic grade, pH, total acidity, volatile acidity, tannins, phenols etc. obtained from black mulberry. Moreover, we have studied the quality of liquors obtained from black mulberry in Canary Islands.

  18. Digital Algorithmic Diabetic Retinopathy Severity Scoring System (An American Ophthalmological Society Thesis).

    Science.gov (United States)

    Slakter, Jason S; Schneebaum, Jeffrey W; Shah, Sabah A

    2015-01-01

    To develop a new diabetic retinopathy severity scoring system and to determine if it can monitor changes from baseline as well as identify precise features that have changed over time. Such a grading system could potentially provide an understanding of the impact of treatments utilizing an algorithmic scoring technique. The traditional ETDRS grading system was examined and a flow algorithm based on the grading approach was created. All visual comparative assessment points, relying on identification of features in relation to prior standard photographic images, were evaluated and quantified. A new grading form was created that provided fields that captured all relevant features required for determining the ETDRS grading score. A computer software algorithm was developed that examines all entered fields and calculates the appropriate diabetic severity score. This diabetic retinopathy scoring algorithm system was successful in generating a severity score comparable to traditional methods of grading images. Validation with traditionally graded images was performed, demonstrating that in a majority of cases, the severity scores were comparable. The algorithmic grading system was then used to analyze images obtained in a large clinical study of diabetic macular edema, resulting in data regarding baseline scoring values, as well as detailed features of the microvasculature that drove the severity scoring results, and changes seen during the trial. This new algorithmic diabetic severity scoring system provides a means to monitor the progression or regression of retinopathy with therapeutic intervention as well as assess the individual microvascular features that may be modified over the course of treatment.

  19. Score-based likelihood ratios for handwriting evidence.

    Science.gov (United States)

    Hepler, Amanda B; Saunders, Christopher P; Davis, Linda J; Buscaglia, JoAnn

    2012-06-10

    Score-based approaches for computing forensic likelihood ratios are becoming more prevalent in the forensic literature. When two items of evidential value are entangled via a scorefunction, several nuances arise when attempting to model the score behavior under the competing source-level propositions. Specific assumptions must be made in order to appropriately model the numerator and denominator probability distributions. This process is fairly straightforward for the numerator of the score-based likelihood ratio, entailing the generation of a database of scores obtained by pairing items of evidence from the same source. However, this process presents ambiguities for the denominator database generation - in particular, how best to generate a database of scores between two items of different sources. Many alternatives have appeared in the literature, three of which we will consider in detail. They differ in their approach to generating denominator databases, by pairing (1) the item of known source with randomly selected items from a relevant database; (2) the item of unknown source with randomly generated items from a relevant database; or (3) two randomly generated items. When the two items differ in type, perhaps one having higher information content, these three alternatives can produce very different denominator databases. While each of these alternatives has appeared in the literature, the decision of how to generate the denominator database is often made without calling attention to the subjective nature of this process. In this paper, we compare each of the three methods (and the resulting score-based likelihood ratios), which can be thought of as three distinct interpretations of the denominator proposition. Our goal in performing these comparisons is to illustrate the effect that subtle modifications of these propositions can have on inferences drawn from the evidence evaluation procedure. The study was performed using a data set composed of cursive writing

  20. RESEARCH ON THE AERODYNAMICS OF BLADE PROFILES OF WIND TURBINES

    Directory of Open Access Journals (Sweden)

    POP E.S.

    2016-09-01

    Full Text Available Small capacity wind turbine performance is influenced in a large extent by the blade profiles aerodynamics. By this point of view, the paper presents the most important aspects of aerodynamic profiles, and aspects concerning their optimization in order to increase performance. The study of blade profiles polar led to the identification of a reference profile, NACA4418, for which the best aerodynamic lift drag ratio is obtained on a big range of attack angles. A flow analysis on the reference profile is performed, using a CFD model of numerical simulations in order to obtain performance for different wind speeds.

  1. Motivational profiles of medical students: association with study effort, academic performance and exhaustion.

    Science.gov (United States)

    Kusurkar, Rashmi A; Croiset, Gerda; Galindo-Garré, Francisca; Ten Cate, Olle

    2013-06-19

    Students enter the medical study with internally generated motives like genuine interest (intrinsic motivation) and/or externally generated motives like parental pressure or desire for status or prestige (controlled motivation). According to Self-determination theory (SDT), students could differ in their study effort, academic performance and adjustment to the study depending on the endorsement of intrinsic motivation versus controlled motivation. The objectives of this study were to generate motivational profiles of medical students using combinations of high or low intrinsic and controlled motivation and test whether different motivational profiles are associated with different study outcomes. Participating students (N = 844) from University Medical Center Utrecht, the Netherlands, were classified to different subgroups through K-means cluster analysis using intrinsic and controlled motivation scores. Cluster membership was used as an independent variable to assess differences in study strategies, self-study hours, academic performance and exhaustion from study. Four clusters were obtained: High Intrinsic High Controlled (HIHC), Low Intrinsic High Controlled (LIHC), High Intrinsic Low Controlled (HILC), and Low Intrinsic Low Controlled (LILC). HIHC profile, including the students who are interest + status motivated, constituted 25.2% of the population (N = 213). HILC profile, including interest-motivated students, constituted 26.1% of the population (N = 220). LIHC profile, including status-motivated students, constituted 31.8% of the population (N = 268). LILC profile, including students who have a low-motivation and are neither interest nor status motivated, constituted 16.9% of the population (N = 143). Interest-motivated students (HILC) had significantly more deep study strategy (p motivated (LIHC) and low-motivation (LILC) students. The interest-motivated profile of medical students (HILC) is associated with good study hours, deep

  2. Motivational profiles of medical students: Association with study effort, academic performance and exhaustion

    Science.gov (United States)

    2013-01-01

    Background Students enter the medical study with internally generated motives like genuine interest (intrinsic motivation) and/or externally generated motives like parental pressure or desire for status or prestige (controlled motivation). According to Self-determination theory (SDT), students could differ in their study effort, academic performance and adjustment to the study depending on the endorsement of intrinsic motivation versus controlled motivation. The objectives of this study were to generate motivational profiles of medical students using combinations of high or low intrinsic and controlled motivation and test whether different motivational profiles are associated with different study outcomes. Methods Participating students (N = 844) from University Medical Center Utrecht, the Netherlands, were classified to different subgroups through K-means cluster analysis using intrinsic and controlled motivation scores. Cluster membership was used as an independent variable to assess differences in study strategies, self-study hours, academic performance and exhaustion from study. Results Four clusters were obtained: High Intrinsic High Controlled (HIHC), Low Intrinsic High Controlled (LIHC), High Intrinsic Low Controlled (HILC), and Low Intrinsic Low Controlled (LILC). HIHC profile, including the students who are interest + status motivated, constituted 25.2% of the population (N = 213). HILC profile, including interest-motivated students, constituted 26.1% of the population (N = 220). LIHC profile, including status-motivated students, constituted 31.8% of the population (N = 268). LILC profile, including students who have a low-motivation and are neither interest nor status motivated, constituted 16.9% of the population (N = 143). Interest-motivated students (HILC) had significantly more deep study strategy (p motivated (LIHC) and low-motivation (LILC) students. Conclusions The interest-motivated profile of medical students (HILC) is

  3. Haematology, testosterone profile and spermiogram of Nigerian ...

    African Journals Online (AJOL)

    The present study was aimed at characterizing the blood, hormone and spermiogram profiles of five adult local breed of Mallard drakes which were obtained from a local farmer. Each drake was examined to be free from diseases or deformity, stabilized and managed intensively during the study period. Semen was obtained ...

  4. Cognitive and Motivational Profile Shape Predicts Mathematical Skills over and above Profile Level

    Science.gov (United States)

    Reimann, Giselle; Stoecklin, Markus; Lavallee, Kristen; Gut, Janine; Frischknecht, Marie-Claire; Grob, Alexander

    2013-01-01

    The interpretation of subtest profiles from intelligence testing remains popular among many practitioners who use subtest performance to draw diagnostic conclusions, in spite of criticism by some researchers, who point to the low reliability and predictive validity of subtest scores in predicting achievement outcomes. Prior research outlines two…

  5. An ultrasound score for knee osteoarthritis

    DEFF Research Database (Denmark)

    Riecke, B F; Christensen, R.; Torp-Pedersen, S

    2014-01-01

    OBJECTIVE: To develop standardized musculoskeletal ultrasound (MUS) procedures and scoring for detecting knee osteoarthritis (OA) and test the MUS score's ability to discern various degrees of knee OA, in comparison with plain radiography and the 'Knee injury and Osteoarthritis Outcome Score' (KOOS......) domains as comparators. METHOD: A cross-sectional study of MUS examinations in 45 patients with knee OA. Validity, reliability, and reproducibility were evaluated. RESULTS: MUS examination for knee OA consists of five separate domains assessing (1) predominantly morphological changes in the medial...... coefficients ranging from 0.75 to 0.97 for the five domains. Construct validity was confirmed with statistically significant correlation coefficients (0.47-0.81, P knee OA. In comparison with standing radiographs...

  6. Distribution of model-based multipoint heterogeneity lod scores.

    Science.gov (United States)

    Xing, Chao; Morris, Nathan; Xing, Guan

    2010-12-01

    The distribution of two-point heterogeneity lod scores (HLOD) has been intensively investigated because the conventional χ(2) approximation to the likelihood ratio test is not directly applicable. However, there was no study investigating th e distribution of the multipoint HLOD despite its wide application. Here we want to point out that, compared with the two-point HLOD, the multipoint HLOD essentially tests for homogeneity given linkage and follows a relatively simple limiting distribution ½χ²₀+ ½χ²₁, which can be obtained by established statistical theory. We further examine the theoretical result by simulation studies. © 2010 Wiley-Liss, Inc.

  7. Optimizing an emperical scoring function for transmembrane protein structure determination.

    Energy Technology Data Exchange (ETDEWEB)

    Young, Malin M.; Sale, Kenneth L.; Gray, Genetha Anne; Kolda, Tamara Gibson

    2003-10-01

    We examine the problem of transmembrane protein structure determination. Like many other questions that arise in biological research, this problem cannot be addressed by traditional laboratory experimentation alone. An approach that integrates experiment and computation is required. We investigate a procedure which states the transmembrane protein structure determination problem as a bound constrained optimization problem using a special empirical scoring function, called Bundler, as the objective function. In this paper, we describe the optimization problem and some of its mathematical properties. We compare and contrast results obtained using two different derivative free optimization algorithms.

  8. Polypropylene obtained through zeolite supported catalysts

    Directory of Open Access Journals (Sweden)

    Queli C. Bastos

    2004-01-01

    Full Text Available Propylene polymerizations were carried out with f2C(Flu(CpZrCl2 and SiMe2(Ind2ZrCl2 catalysts supported on silica, zeolite sodic mordenite (NaM and acid mordenite (HM. The polymerizations were performed at different temperatures and varying aluminium/zirconium molar ratios ([Al]/[Zr]. The effect of these reaction parameters on the catalyst activity was investigated using a proposed statistical experimental planning. In the case of f2C(Flu(CpZrCl2, SiO2 and NaM were used as support and the catalyst performance evaluated using toluene and pentane as polymerization solvent. The molecular weight, molecular weight distribution, melting point and crystallinity of the polymers were examined. The results indicate very high activities for the syndiospecific heterogeneous system. Also, the polymers obtained had superior Mw and stereoregularity.

  9. ORIENTATION OF ENTERPRISES TOWARD OBTAINING COMPETITIVE

    Directory of Open Access Journals (Sweden)

    PAUL BOGDAN ZAMFIR

    2015-10-01

    Full Text Available In this paper I proposed to emphasize the importance of obtaining competitive advantage by companies on EU internal market. The huge EU market, offers for participating companies the possibility to achieve significant economies of scale and numerous niches (segments market, which can be covered with large quantities of goods, the condition is that niches to be discovered in time, and the firms to be able to adapt promptly at their needs. Thus, the most important positive effect derives from the fact that companies have at their disposal a vast market consisting approximately 500 million consumers, free of customs duties and other restrictions inhindering the movement of goods. On this background, the companies can achieve high series production and thereby can reduce their cost of production and increase their competitiveness. In this context, the companies must meet the standards of the European Union, if they really want to gain competitive advantage on EU market.

  10. Cooperation through image scoring in humans.

    Science.gov (United States)

    Wedekind, C; Milinski, M

    2000-05-05

    The "tragedy of the commons," that is, the selfish exploitation of resources in the public domain, is a reason for many of our everyday social conflicts. However, humans are often more helpful to others than evolutionary theory would predict, unless indirect reciprocity takes place and is based on image scoring (which reflects the way an individual is viewed by a group), as recently shown by game theorists. We tested this idea under conditions that control for confounding factors. Donations were more frequent to receivers who had been generous to others in earlier interactions. This shows that image scoring promotes cooperative behavior in situations where direct reciprocity is unlikely.

  11. Assigning Numerical Scores to Linguistic Expressions

    Directory of Open Access Journals (Sweden)

    María Jesús Campión

    2017-07-01

    Full Text Available In this paper, we study different methods of scoring linguistic expressions defined on a finite set, in the search for a linear order that ranks all those possible expressions. Among them, particular attention is paid to the canonical extension, and its representability through distances in a graph plus some suitable penalization of imprecision. The relationship between this setting and the classical problems of numerical representability of orderings, as well as extension of orderings from a set to a superset is also explored. Finally, aggregation procedures of qualitative rankings and scorings are also analyzed.

  12. [Prognostic value of GRACE scores versus TIMI score in acute coronary syndromes].

    Science.gov (United States)

    Correia, Luis C L; Freitas, Rafael; Bittencourt, Ana P; Souza, Alexandre C; Almeida, Maria C; Leal, Jamile; Esteves, José Péricles

    2010-05-01

    Although the TIMI score is the one most frequently used in acute coronary syndromes (ACS) without ST-segment elevation, the GRACE score has potential prognostic superiority, as it was created based on an observational registry, part of the variables is treated in a semi-quantitative form and renal function is taken into account in its calculation. To test the hypothesis that the GRACE risk score has superior in-hospital prognostic value, when compared to the TIMI score in patients admitted with ACS. Individuals with unstable angina or myocardial infarction without ST-segment elevation, consecutively admitted at the Coronary Unit between August 2007 and January 2009, were included in the study. A total of 154 patients aged 71 +/- 13 years, of which 56% were females, with a GRACE median of 117 and a TIMI median of 3 were studied. During the hospitalization period, the incidence of events was 8.4% (12 deaths and 1 non-fatal infarction). The Hosmer-Lemeshow test applied to the GRACE score presented an chi2 of 5.3 (P = 0.72), whereas the TIMI score presented an chi2 of 1.85 (P = 0.60). Therefore, both scores presented good calibration. As for the analysis of discrimination, the GRACE score presented a C-statistics of 0.91 (95%CI= 0.86 - 0.97), significantly superior to the C-statistics of 0.69 of the TIMI score (95%CI = 0.55 - 0.84) - P = 0.02 for the difference between the scores. Regarding the prediction of hospital events in patients with ACS, the GRACE score has superior prognostic capacity when compared to the TIMI score.

  13. Algorithm Improvement Program Nuclide Identification Algorithm Scoring Criteria And Scoring Application - DNDO.

    Energy Technology Data Exchange (ETDEWEB)

    Enghauser, Michael [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-02-01

    The goal of the Domestic Nuclear Detection Office (DNDO) Algorithm Improvement Program (AIP) is to facilitate gamma-radiation detector nuclide identification algorithm development, improvement, and validation. Accordingly, scoring criteria have been developed to objectively assess the performance of nuclide identification algorithms. In addition, a Microsoft Excel spreadsheet application for automated nuclide identification scoring has been developed. This report provides an overview of the equations, nuclide weighting factors, nuclide equivalencies, and configuration weighting factors used by the application for scoring nuclide identification algorithm performance. Furthermore, this report presents a general overview of the nuclide identification algorithm scoring application including illustrative examples.

  14. Algorithm improvement program nuclide identification algorithm scoring criteria and scoring application.

    Energy Technology Data Exchange (ETDEWEB)

    Enghauser, Michael [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2016-02-01

    The goal of the Domestic Nuclear Detection Office (DNDO) Algorithm Improvement Program (AIP) is to facilitate gamma-radiation detector nuclide identification algorithm development, improvement, and validation. Accordingly, scoring criteria have been developed to objectively assess the performance of nuclide identification algorithms. In addition, a Microsoft Excel spreadsheet application for automated nuclide identification scoring has been developed. This report provides an overview of the equations, nuclide weighting factors, nuclide equivalencies, and configuration weighting factors used by the application for scoring nuclide identification algorithm performance. Furthermore, this report presents a general overview of the nuclide identification algorithm scoring application including illustrative examples.

  15. NCACO-score: An effective main-chain dependent scoring function for structure modeling

    Directory of Open Access Journals (Sweden)

    Dong Xiaoxi

    2011-05-01

    Full Text Available Abstract Background Development of effective scoring functions is a critical component to the success of protein structure modeling. Previously, many efforts have been dedicated to the development of scoring functions. Despite these efforts, development of an effective scoring function that can achieve both good accuracy and fast speed still presents a grand challenge. Results Based on a coarse-grained representation of a protein structure by using only four main-chain atoms: N, Cα, C and O, we develop a knowledge-based scoring function, called NCACO-score, that integrates different structural information to rapidly model protein structure from sequence. In testing on the Decoys'R'Us sets, we found that NCACO-score can effectively recognize native conformers from their decoys. Furthermore, we demonstrate that NCACO-score can effectively guide fragment assembly for protein structure prediction, which has achieved a good performance in building the structure models for hard targets from CASP8 in terms of both accuracy and speed. Conclusions Although NCACO-score is developed based on a coarse-grained model, it is able to discriminate native conformers from decoy conformers with high accuracy. NCACO is a very effective scoring function for structure modeling.

  16. Label-free peptide profiling of Orbitrap™ full mass spectra

    Directory of Open Access Journals (Sweden)

    Titulaer Mark K

    2011-01-01

    Full Text Available Abstract Background We developed a new version of the open source software package Peptrix that can yet compare large numbers of Orbitrap™ LC-MS data. The peptide profiling results for Peptrix on MS1 spectra were compared with those obtained from a small selection of open source and commercial software packages: msInspect, Sieve™ and Progenesis™. The properties compared in these packages were speed, total number of detected masses, redundancy of masses, reproducibility in numbers and CV of intensity, overlap of masses, and differences in peptide peak intensities. Reproducibility measurements were taken for the different MS1 software applications by measuring in triplicate a complex peptide mixture of immunoglobulin on the Orbitrap™ mass spectrometer. Values of peptide masses detected from the high intensity peaks of the MS1 spectra by peptide profiling were verified with values of the MS2 fragmented and sequenced masses that resulted in protein identifications with a significant score. Findings Peptrix finds about the same number of peptide features as the other packages, but peptide masses are in some cases approximately 5 to 10 times less redundant present in the peptide profile matrix. The Peptrix profile matrix displays the largest overlap when comparing the number of masses in a pair between two software applications. The overlap of peptide masses between software packages of low intensity peaks in the spectra is remarkably low with about 50% of the detected masses in the individual packages. Peptrix does not differ from the other packages in detecting 96% of the masses that relate to highly abundant sequenced proteins. MS1 peak intensities vary between the applications in a non linear way as they are not processed using the same method. Conclusions Peptrix is capable of peptide profiling using Orbitrap™ files and finding differential expressed peptides in body fluid and tissue samples. The number of peptide masses detected in

  17. Label-free peptide profiling of Orbitrap™ full mass spectra.

    Science.gov (United States)

    Titulaer, Mark K; de Costa, Dominique; Stingl, Christoph; Dekker, Lennard J; Sillevis Smitt, Peter Ae; Luider, Theo M

    2011-01-27

    We developed a new version of the open source software package Peptrix that can yet compare large numbers of Orbitrap™ LC-MS data. The peptide profiling results for Peptrix on MS1 spectra were compared with those obtained from a small selection of open source and commercial software packages: msInspect, Sieve™ and Progenesis™. The properties compared in these packages were speed, total number of detected masses, redundancy of masses, reproducibility in numbers and CV of intensity, overlap of masses, and differences in peptide peak intensities. Reproducibility measurements were taken for the different MS1 software applications by measuring in triplicate a complex peptide mixture of immunoglobulin on the Orbitrap™ mass spectrometer. Values of peptide masses detected from the high intensity peaks of the MS1 spectra by peptide profiling were verified with values of the MS2 fragmented and sequenced masses that resulted in protein identifications with a significant score. Peptrix finds about the same number of peptide features as the other packages, but peptide masses are in some cases approximately 5 to 10 times less redundant present in the peptide profile matrix. The Peptrix profile matrix displays the largest overlap when comparing the number of masses in a pair between two software applications. The overlap of peptide masses between software packages of low intensity peaks in the spectra is remarkably low with about 50% of the detected masses in the individual packages. Peptrix does not differ from the other packages in detecting 96% of the masses that relate to highly abundant sequenced proteins. MS1 peak intensities vary between the applications in a non linear way as they are not processed using the same method. Peptrix is capable of peptide profiling using Orbitrap™ files and finding differential expressed peptides in body fluid and tissue samples. The number of peptide masses detected in Orbitrap™ files can be increased by using more MS1 peptide

  18. Cleaning efficiency of anatomic endodontic technology, ProFile System and Manual Instrumentation in oval-shaped root canals: an in vitro study.

    Science.gov (United States)

    Reddy, E Sujayeendranath; Sainath, Dinapadu; Narenderreddy, M; Pasari, Srikanth; Vallikanthan, Sangeetha; Sindhurareddy, G

    2013-07-01

    This in vitro study is an attempt to compare the effectiveness in cleaning oval shaped root canals using Anatomic Endodontic Technology (AET®), ProFile system® and Manual Instrumentation with K-files. Sixty oval shaped single rooted maxillary and mandibular premolars with straight canals were divided in to three groups. The root canals were, confirmed as being oval shape by means of radiographs made in a buccolingual and mesiodistal direction. Automated canal preparation was performed using Anatomic Endodontic Technology (group 1) and the ProFile system® (group 2). Manual instrumentation (group 3) was performed with k-files. Irrigation was performed using alternatively 3% NaOCl and 17% EDTA, followed by rinsing with normal saline. The roots were split longitudinally into two halves and examined under a scanning electron microscope. The presence of debris and smear layer was recorded at distances 1, 5 and 10 mm from the working length using a three step scoring scale. Mean scores for debris and smear layer was calculated and statistically analyzed for between and within groups significance, using the Kruskal-Wallis nonparametric ANOVA test and Bonferroni's multiple comparison test. At 1, 5 and 10 mm levels the root canals prepared with AET had significantly less surface debris and smear layer on the canal walls as compared to canals prepared with ProFile system® or manual instrumentation. For all three groups significantly lower mean smear layer scores (p < 0.05) were recorded at 5 and 10 mm levels compared with the 1 mm level. Significantly lower mean debris scores (p < 0.05) were also recorded at 5 and 10 mm levels for the AET group whereas no significant differences were found between the three levels for the ProFile system® and manual instrumentation groups. Although better instrumentation scores were obtained in canals prepared with AET, complete cleanliness was not achieved with any of the techniques and instruments investigated.

  19. DisoMCS: Accurately Predicting Protein Intrinsically Disordered Regions Using a Multi-Class Conservative Score Approach.

    Directory of Open Access Journals (Sweden)

    Zhiheng Wang

    Full Text Available The precise prediction of protein intrinsically disordered regions, which play a crucial role in biological procedures, is a necessary prerequisite to further the understanding of the principles and mechanisms of protein function. Here, we propose a novel predictor, DisoMCS, which is a more accurate predictor of protein intrinsically disordered regions. The DisoMCS bases on an original multi-class conservative score (MCS obtained by sequence-order/disorder alignment. Initially, near-disorder regions are defined on fragments located at both the terminus of an ordered region connecting a disordered region. Then the multi-class conservative score is generated by sequence alignment against a known structure database and represented as order, near-disorder and disorder conservative scores. The MCS of each amino acid has three elements: order, near-disorder and disorder profiles. Finally, the MCS is exploited as features to identify disordered regions in sequences. DisoMCS utilizes a non-redundant data set as the training set, MCS and predicted secondary structure as features, and a conditional random field as the classification algorithm. In predicted near-disorder regions a residue is determined as an order or a disorder according to the optimized decision threshold. DisoMCS was evaluated by cross-validation, large-scale prediction, independent tests and CASP (Critical Assessment of Techniques for Protein Structure Prediction tests. All results confirmed that DisoMCS was very competitive in terms of accuracy of prediction when compared with well-established publicly available disordered region predictors. It also indicated our approach was more accurate when a query has higher homologous with the knowledge database.The DisoMCS is available at http://cal.tongji.edu.cn/disorder/.

  20. Motivational profiles in physical education and their relation to the theory of planned behavior.

    Science.gov (United States)

    Moreno-Murcia, Juan Antonio; Cervelló Gimeno, Eduardo; Hernández, Elisa Huéscar; Pedreño, Noelia Belan-do; Rodríguez Marín, Jesús Jesus

    2013-01-01

    The aim of this study was to establish motivational profiles for doing physical activity according to the variables from the theory of planned action in a sample of 698 students aged 14 to 16. The instruments used were the Questionnaire of Behavioral Regulation in Sport (BRQ-R) and the Questionnaire of the Theory of Planned Behavior (TCP). Cluster analysis revealed two motivational profiles: a "self-determined "profile with high scores in intrinsic motivation and low scores in extrinsic motivation and amotivation, and a "non self- determined "profile with low scores in intrinsic motivation and high scores in extrinsic motivation and amotivation. Positive significant differences in attitudes, norms, and intent to control were found for the self-determined profile related to "non self-determined "profile. Key PointsA "self-determined "profile was found with higher scores for the four types of intrinsic motivations (general, knowledge, stimulation and achievement) and identified regulation than for introjected and external regulation.A "non self-determined "profile was found with higher scores for external, introjected regulation and amotivation than for the four types of intrinsic motivation (general, knowledge, stimulation and achievement).In the context of the "non self-determined profile "we could encourage programs that adapt to these needs in such a way that they contribute to increasing the rates of doing physical activity in the population.

  1. Ground red peppers: capsaicinoids content, Scoville scores, and discrimination by an electronic nose.

    Science.gov (United States)

    Korel, Figen; Bagdatlioglu, Neriman; Balaban, Murat O; Hişil, Yaşar

    2002-05-22

    High-pressure liquid chromatography (HPLC) was used to determine the capsaicin, dihydrocapsaicin, and total capsaicinoids levels of different ground red pepper samples obtained from local retail markets in Izmir, Turkey. Scoville scores were determined using sensory tests. An electronic nose (EN) was used to discriminate ground red pepper samples by headspace volatiles. EN data were analyzed using discriminant function analysis (DFA). An overall correct classification rate of pepper varieties by EN of 91% was obtained. A linear correlation between capsaicin, dihydrocapsaicin, and total capsaicinoids and Scoville scores was also observed, and R (2) values of 0.89, 0.85, and 0.91 were obtained, respectively.

  2. CALCULATION AND COMPARISON OF NUTRIENT DENSITY/QUALITY SCORES FOR COMMONLY CONSUMED FRESH FRUIT

    Directory of Open Access Journals (Sweden)

    Gail RAMPERSAUD

    2012-01-01

    Full Text Available A number of methods have been developed to quantitatively describe the nutrient density/quality (ND/Q of foods and beverages. Seventeen commonly consumed fresh fruits were evaluated using six published ND/Q methods. Nutrient data for each fruit were obtained from the USDA National Nutrient Database for Standard Reference, Release 23. Numerical scores were produced and ranked for each fruit and method. The resulting ND/Q scores varied in range and magnitude but there was good to strong correlation among methods. The relative scores indicated that cantaloupe, strawberries, oranges, and grapefruit generally had the highest ND/Q scores across all methods. Further analysis indicated that vitamins C and A, nutrients common to all six methods, affected ND/Q scores substantially for some but not all fruits, suggesting that high values for specific nutrients may influence relative scoring and higher scores may not necessarily reflect a greater variety or balance of nutrients. Fresh fruits vary in their ND/Q as defined by several quantitative scoring systems. In this analysis, consistent results in how the fruits were ranked were obtained when using six different methods to quantify ND/Q for select fresh fruit.

  3. Scoring system for CT scan findings of ovarian cystic lesions

    Energy Technology Data Exchange (ETDEWEB)

    Hattori, Kaoru

    1987-09-01

    It is important to preoperatively establish a diagnosis of a gynecologic pelvic mass. A group of 137 female patients with suspected pelvic cystic lesions were studied by computerized tomography (CT). Histologically, 22 patients were proved to have ovarian cystadenocarcinoma and 115 patients a benign cystic mass, i.e. cystadenoma, lutein cyst, endometrial cyst, retentional cyst and paraovarian cyst. A scoring system was made to obtain higher accuracy in CT evaluation of ovarian cystic lesions. It includes seven factors, (1) volume, (2) solid component protruding from the wall, (3) thickness of the wall, (4) focal thickening of the wall, (5) loculation, (6) attenuation number of the tumor and (7) nonhomogenousess of the tumor. Using this scoring system, a correct differential diagnosis was made in all cases except 7, 4 uterine fibroids with remarkable degenaration, a large endometrial cyst with a high attenuation number, a dermoid cyst with an irregular pattern and a mucinous cystadenoma with benign solid component. The accuracy of diagnosis was 100 % in malignant masses and 93.9 % in benign masses. This scoring system was shown to have clinical significance for the differential diagnosis of a pelvic cystic lesions.

  4. [Effects of Le-Fort-I-Osteotomy on nasalance scores].

    Science.gov (United States)

    Zemann, Wolfgang; Feichtinger, Matthias; Santler, Gert; Kärcher, Hans

    2006-07-01

    Nasalance represents a measure of the relative amount of oral and nasal acoustic energy produced by a speaker. Literature shows changes in nasalance after surgery of the oropharynx. The aim of this prospective study was to evaluate the outcome of speech and nasalance scores after Le-Fort-I-Osteotomy. A total of 20 individuals with normal speech development were examined preoperatively and 6 weeks postoperatively with the Nasometer 6200 (Kay-Elemetrics, USA) after bimaxillary surgery. The tone materials used comprised the standardized text passage: "Ein Kindergeburtstag", the vowels: /a/, /e/, /i/, /o/, /u/ and a syllable repetition subtest. All patients showed changes in nasalance scores 6 weeks postoperatively. There were no significant changes reading the standard text. The syllable repetition test showed significant changes for repetition of "ma ma ma" and "na na na" (p=0,003, respectively p=0,033). Intonation of the vowel /a/1 also revealed significant changes regarding the pre- and postoperative values (p=0,006). However, the obtained values had no significant impact on the nasality characteristics of speech. This study confirms that maxillary osteotomies can result in significant changes of nasalance scores. However these changes do not have any impact on normal speech and voice.

  5. Propensity Score Matching within Prognostic Strata

    Science.gov (United States)

    Kelcey, Ben

    2013-01-01

    A central issue in nonexperimental studies is identifying comparable individuals to remove selection bias. One common way to address this selection bias is through propensity score (PS) matching. PS methods use a model of the treatment assignment to reduce the dimensionality of the covariate space and identify comparable individuals. parallel to…

  6. Surgical Apgar Score Predicts Post- Laparatomy Complications

    African Journals Online (AJOL)

    complications following laparatomy in our setting with good predictive accuracy. Introduction. Peri-operative risk stratification of mortality and morbidity is important in the provision of health care to ensure appropriate resource allocation and informed decision making (1). Many risk-scoring systems are not easily calculated at ...

  7. Surgical Apgar Score Predicts Postoperative Complications in ...

    African Journals Online (AJOL)

    measure of the operative care provided (1). A simple surgical outcome score, ... Quality Improvement Program (6). Patients were subsequently ... Table 1: Prevalence of major complications in postoperative period. Complications. Frequency. Percent. (N=334). Intensive unit care. 50. 15.0%. Neurological deficit. 45. 13.5%.

  8. AVERAGE SCORE OF THE UNIFIED STATE EXAMINATION

    Directory of Open Access Journals (Sweden)

    L. M. Nurieva

    2017-01-01

    Full Text Available Introduction. Summing up the results of the Unified State Exam (USE is traditionally based on comparing the average scores for institutions or territories, without taking into account what the indicator of the quality of education really represents.The aim of the article is to clarify the content «average score» on the example of the Mathematics federal testing results.Methodology and research methods. The methodology of comprehensive analysis is used, including the methods of comparative and statistical data analysis published following the exam results. As well, the parallel analysis of data used in the researches of the National Research University «The Higher School of Economics» (HSE was conducted.Results and scientific novelty. It is found out that the average score in the Unified State Exam in mathematics largely depends on peculiarities of testing and assessment materials, a scoring system of leveling nature and results of training students for solving simple problems.Practical significance. The authors suppose that the study findings will contribute to the improvement of methods and technologies of carrying the Unified State Exam. 

  9. FEEDBACK SCORING SYSTEMS FOR REUSABLE KINDERGARTEN WORKBOOKS.

    Science.gov (United States)

    GACH, PENELOPE J.; AND OTHERS

    THE DEVELOPMENT OF ECONOMICAL FEEDBACK SCORING SYSTEMS FOR REUSABLE KINDERGARTEN WORKBOOKS IS DESCRIBED. THREE PROTOTYPE SYSTEMS WERE DEVELOPED--(1) A METAL FOIL ACTIVATING AN ELECTRICAL PROBE, (2) A METAL FOIL REACTING WITH A MAGNETIC PROBE, AND (3) INVISIBLE FLUORESCENT INK REVEALED BY THE APPLICATION OF LONGWAVE ULTRAVIOLET LIGHT. (MS)

  10. Small business credit scoring and credit availability

    OpenAIRE

    Berger, Allen N.; Frame, W. Scott; Berger, Allen N.; Frame, W. Scott

    2005-01-01

    U.S. commercial banks are increasingly using credit scoring models to underwrite small business credits. This paper discusses this technology, evaluates the research findings on the effects of this technology on small business credit availability, and links these findings to a number of research and public policy issues.

  11. Score Matrix for HWBI Forecast Model

    Science.gov (United States)

    2000-2010 Annual State-Scale Service and Domain scores used to support the approach for forecasting EPA's Human Well-Being Index. A modeling approach was developed based relationship function equations derived from select economic, social and ecosystem final goods and service scores and calculated human well-being index and related domain scores. These data are being used in a secondary capacity. The foundational data and scoring techniques were originally described in: a) U.S. EPA. 2012. Indicators and Methods for Constructing a U.S. Human Well-being Index (HWBI) for Ecosystem Services Research. Report. EPA/600/R-12/023. pp. 121; and b) U.S. EPA. 2014. Indicators and Methods for Evaluating Economic, Ecosystem and Social Services Provisioning. Report. EPA/600/R-14/184. pp. 174. Mode Smith, L. M., Harwell, L. C., Summers, J. K., Smith, H. M., Wade, C. M., Straub, K. R. and J.L. Case (2014).This dataset is associated with the following publication:Summers , K., L. Harwell , and L. Smith. A Model For Change: An Approach for Forecasting Well-Being From Service-Based Decisions. ECOLOGICAL INDICATORS. Elsevier Science Ltd, New York, NY, USA, 69: 295-309, (2016).

  12. Correlation between international prostate symptom score and ...

    African Journals Online (AJOL)

    Objective: To determine the correlation between severity of symptoms using the International Prostate Symptom Score (IPSS) and uroflowmetry in patients with lower urinary tract symptoms-benign prostatic hyperplasia (LUTS-BPH). Patients and Methods: We prospectively collected data from 51 consecutive men, who ...

  13. Normalization of the Psychometric Hepatic Encephalopathy score ...

    African Journals Online (AJOL)

    This is an open access article distributed under the terms of the Creative Commons. Attribution-Non Commercial-Share ... encephalopathy score (PHES) and evaluate the prevalence of minimal hepatic encephalopathy (MHE) among .... that can affect cognitive function; (3) diabetes mellitus;. (4) significant comorbid illness ...

  14. How helpful are early warning scores?

    Science.gov (United States)

    Carberry, Martin; Clements, Pauline; Headley, Elaine

    This article discusses a literature review examining UK practice and the origins, benefits and limitations of early warning scores. An accompanying article (page 15) discusses the introduction of clinical-based trigger questions to help ward-based nurses to identify patients whose condition is deteriorating.

  15. Incorporating Quality Scores in Meta-Analysis

    Science.gov (United States)

    Ahn, Soyeon; Becker, Betsy Jane

    2011-01-01

    This paper examines the impact of quality-score weights in meta-analysis. A simulation examines the roles of study characteristics such as population effect size (ES) and its variance on the bias and mean square errors (MSEs) of the estimators for several patterns of relationship between quality and ES, and for specific patterns of systematic…

  16. Effects of heterogeneity on bank efficiency scores

    NARCIS (Netherlands)

    Bos, J. W. B.; Koetter, M.; Kolari, J. W.; Kool, C. J. M.

    2009-01-01

    Bank efficiency estimates often serve as a proxy of managerial skill since they quantify sub-optimal production choices. But such deviations can also be due to omitted systematic differences among banks. In this study, we examine the effects of heterogeneity on bank efficiency scores. We compare

  17. [Intraoperative crisis and surgical Apgar score].

    Science.gov (United States)

    Oshiro, Masakatsu; Sugahara, Kazuhiro

    2014-03-01

    Intraoperative crisis is an inevitable event to anesthesiologists. The crisis requires effective and coordinated management once it happened but it is difficult to manage the crises properly under extreme stressful situation. Recently, it is reported that the use of surgical crisis checklists is associated with significant improvement in the management of operating-room crises in a high-fidelity simulation study. Careful preoperative evaluation, proper intraoperative management and using intraoperative crisis checklists will be needed for safer perioperative care in the future. Postoperative complication is a serious public health problem. It reduces the quality of life of patients and raises medical cost. Careful management of surgical patients is required according to their postoperative condition for preventing postoperative complications. A 10-point surgical Apgar score, calculated from intraoperative estimated blood loss, lowest mean arterial pressure, and lowest heart rate, is a simple and available scoring system for predicting postoperative complications. It undoubtedly predicts higher than average risk of postoperative complications and death within 30 days of surgery. Surgical Apgar score is a bridge between proper intraoperative and postoperative care. Anesthesiologists should make effort to reduce the postoperative complication and this score is a tool for it.

  18. HEART score to further risk stratify patients with low TIMI scores.

    Science.gov (United States)

    Marcoon, Shannon; Chang, Anna Marie; Lee, Betsy; Salhi, Rama; Hollander, Judd E

    2013-03-01

    The ability to risk stratify patients presenting to the emergency department (ED) with potential acute coronary syndrome (ACS) is critical. The thrombolysis in myocardial infarction (TIMI) risk score can risk stratify ED patients with potential ACS but cannot identify patients safe for ED discharge. The symptom-based HEART score identifies very low-risk patients. Our hypothesis was that patients with a TIMI score of 0 or 1 may be stratified further with the HEART score to identify a group of patients at less than 1% risk of 30-day cardiovascular events. We conducted a secondary analysis of a prospective cohort study in a tertiary care hospital ED. Patients with potential ACS who were >30 years of age were included. Data collected included demographics, history, electrocardiogram, laboratories, and components of the TIMI and HEART scores. Follow-up was conducted by structured record review and phone. The main outcome was a composite of death, acute myocardial infarction, or revascularization at 30 days. There were 8815 patients enrolled (mean age, 52.8 ± 15.1 years; 57% women, and 69% black). At 30 days, the composite event rate was 8.0% (660 patients): 108 deaths, 410 acute myocardial infarction, and 301 revascularizations. Of the 485 patients with both a TIMI score of 0 and a HEART score of 0, there were no cardiovascular events (95% confidence interval, 0-0.8%); but no other score combination had an upper limit confidence interval less than 1%. At all levels of TIMI score, the HEART score was able to further substratify patients with respect to 30-day risk. A HEART score of 0 in a patient with a TIMI of 0 identified a group of patients at less than 1% risk for 30-day adverse events.

  19. WAYS OF OBTAINING FINANCING BY TOUR OPERATORS

    Directory of Open Access Journals (Sweden)

    CARLAN ADRIANA

    2015-12-01

    Full Text Available domanin.Romania is a country with highly touristic potential that is not exploited to maximum. In order to reach a high quality level of tourism permanent development and modernization are needed and also the establishment of new businesses That conducts other activities other than those which takes place in our country. Ways of getting funds are multiple, depending on individual needs.To develop tourism activities it is necessary to require some funding that can come from various sources: auto-financing, loans from various banks or from third parties and grants offered by the European Union. There are many programs designed to support the development of tourism, such as ROP that allows people to access grants in order to implement projects for the establishment and the development of the activity in the touristic field. The purpose of this article is to highlight funding opportunities for the tourism operators and to assist them in choosing the appropriate form of financing of the current activity or the activity they want to implement in the future and description of how to obtain the necessary funds from various sources.

  20. HOW TO OBTAIN BOOKS FOR YOUR GROUP

    CERN Multimedia

    Head Librarian

    2000-01-01

    The wide variety of scientific and technical activity engaged in by people working at CERN means that the Library cannot always provide a deep on-site coverage in areas which are outside the core subjects of particle physics and accelerators. As many of you have already experienced, one way of solving this is to borrow books from other libraries. Our Inter-Library Loan (ILL) service currently obtains about 1000 books on loan per year for readers at CERN. However, there may be books which groups need on a more permanent basis, in which case a loan from either our own collection or via ILL is not the appropriate solution. Instead, groups might prefer to purchase such books from their own budgets. To facilitate this, the CERN Library has set up a procedure with the SPL Division, by which you can submit your purchase request to us and be charged via a TID when you receive the book. In addition, via our database interface WebLib, we can provide you with a private virtual catalogue of your group's collection, which...

  1. Normative adductor squeeze tests scores in rugby.

    Science.gov (United States)

    Hodgson, Lisa; Hignett, Tom; Edwards, Kim

    2015-05-01

    Groin pain is a common problem. Adductor squeeze tests are used to diagnose, monitor and prophylactically determine the risk of developing groin pain. This study defines normative adductor squeeze scores in professional rugby that will facilitate strength monitoring during screening. Using a sphygnamometer, squeeze scores were collected, at one professional rugby club as part of the pre-season screening for two seasons. Scores were collected in four positions. For all positions mean strength and 95% confidence intervals were calculated. Data were collected for 81 athletes. Mean strength for adduction at 60° was 220.1 (212.2-228.1); 0° 211.1 (201.7-220.5); 90°90° 198.8 (190.0-207.7); 90°90° supported 224.9 (214.9-234.9). Backs had lower squeeze scores than forwards for 0°, 90°:90° and 90°:90° supported (p > 0.05 for all four tests); older players had lower scores, as did shorter and lighter players (p > 0.05 except for height with test 60° p = 0.048 and test 90°:90° supported p = 0.035). This study establishes references ranges for adductor squeeze tests for normative pre-season data in non-injured rugby players. This information will enable evaluation and inform return to play judgements following adductor related injury. Copyright © 2014 Elsevier Ltd. All rights reserved.

  2. The associations between yogurt consumption, diet quality, and metabolic profiles in children in the USA.

    Science.gov (United States)

    Zhu, Yong; Wang, Huifen; Hollis, James H; Jacques, Paul F

    2015-06-01

    Recent studies have shown that yogurt consumption was associated with better diet quality and a healthier metabolic profile in adults. However, such associations have not been investigated in children. The present study examined the associations in children using data from a nationally representative survey. Data from 5,124 children aged 2-18 years, who participated in the National Health and Nutrition Examination Survey (NHANES) between 2003 and 2006 in the USA were analyzed. The frequency of yogurt consumption over 12 months was determined using a validated food frequency questionnaire. Diet quality was assessed by the Healthy Eating Index 2005 (HEI-2005) using one 24-HR dietary recall, and metabolic profiles were obtained from the NHANES laboratory data. It was found that only 33.1 % of children consumed yogurt at least once per week (frequent consumers). Adjusting for covariates, frequent consumers had better diet quality than infrequent consumers, as indicated by a higher HEI-2005 total score (P = 0.04). Frequent yogurt consumption was associated with a lower fasting insulin level (P yogurt consumption was not associated with body weight, fasting glucose, serum lipid profiles, C-reactive protein, and blood pressures (all P > 0.05). These results suggest that frequent yogurt consumption may contribute to improved diet quality and a healthier insulin profile in children. Future longitudinal studies and clinical trials in children are warranted to explore the health benefits of yogurt consumption.

  3. GLL RPT IONOSPHERE PROFILES

    Data.gov (United States)

    National Aeronautics and Space Administration — The Galileo Radio Propagation Team Ionosphere Profile data set is small number of electron density profiles derived from radio occultation data collected while...

  4. GHGRP Industrial Profiles

    Science.gov (United States)

    EPA's Greenhouse Gas Reporting Program periodically produces detailed profiles of the various industries that report under the program. These profiles contain detailed analyses. This page hosts data highlights for all sectors.

  5. HOPWA Performance Profiles

    Data.gov (United States)

    Department of Housing and Urban Development — HOPWA Performance Profiles are generated quarterly for all agencies receiving HOPWA formula or competitive grants. Performance Profiles are available at the national...

  6. Automatic coronary calcium scoring using noncontrast and contrast CT images

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Guanyu, E-mail: yang.list@seu.edu.cn; Chen, Yang; Shu, Huazhong [Laboratory of Image Science and Technology, School of Computer Science and Engineering, Southeast University, No. 2, Si Pai Lou, Nanjing 210096 (China); Centre de Recherche en Information Biomédicale Sino-Français (LIA CRIBs), Nanjing 210096 (China); Key Laboratory of Computer Network and Information Integration, Southeast University, Ministry of Education, Nanjing 210096 (China); Ning, Xiufang; Sun, Qiaoyu [Laboratory of Image Science and Technology, School of Computer Science and Engineering, Southeast University, No. 2, Si Pai Lou, Nanjing 210096 (China); Key Laboratory of Computer Network and Information Integration, Southeast University, Ministry of Education, Nanjing 210096 (China); Coatrieux, Jean-Louis [INSERM-U1099, Rennes F-35000 (France); Labotatoire Traitement du Signal et de l’Image (LTSI), Université de Rennes 1, Campus de Beaulieu, Bat. 22, Rennes 35042 Cedex (France); Centre de Recherche en Information Biomédicale Sino-Français (LIA CRIBs), Nanjing 210096 (China)

    2016-05-15

    Purpose: Calcium scoring is widely used to assess the risk of coronary heart disease (CHD). Accurate coronary artery calcification detection in noncontrast CT image is a prerequisite step for coronary calcium scoring. Currently, calcified lesions in the coronary arteries are manually identified by radiologists in clinical practice. Thus, in this paper, a fully automatic calcium scoring method was developed to alleviate the work load of the radiologists or cardiologists. Methods: The challenge of automatic coronary calcification detection is to discriminate the calcification in the coronary arteries from the calcification in the other tissues. Since the anatomy of coronary arteries is difficult to be observed in the noncontrast CT images, the contrast CT image of the same patient is used to extract the regions of the aorta, heart, and coronary arteries. Then, a patient-specific region-of-interest (ROI) is generated in the noncontrast CT image according to the segmentation results in the contrast CT image. This patient-specific ROI focuses on the regions in the neighborhood of coronary arteries for calcification detection, which can eliminate the calcifications in the surrounding tissues. A support vector machine classifier is applied finally to refine the results by removing possible image noise. Furthermore, the calcified lesions in the noncontrast images belonging to the different main coronary arteries are identified automatically using the labeling results of the extracted coronary arteries. Results: Forty datasets from four different CT machine vendors were used to evaluate their algorithm, which were provided by the MICCAI 2014 Coronary Calcium Scoring (orCaScore) Challenge. The sensitivity and positive predictive value for the volume of detected calcifications are 0.989 and 0.948. Only one patient out of 40 patients had been assigned to the wrong risk category defined according to Agatston scores (0, 1–100, 101–300, >300) by comparing with the ground

  7. Relationship between Students' Scores on Research Methods and Statistics, and Undergraduate Project Scores

    Science.gov (United States)

    Ossai, Peter Agbadobi Uloku

    2016-01-01

    This study examined the relationship between students' scores on Research Methods and statistics, and undergraduate project at the final year. The purpose was to find out whether students matched knowledge of research with project-writing skill. The study adopted an expost facto correlational design. Scores on Research Methods and Statistics for…

  8. Development of the Crohn's disease digestive damage score, the Lémann score

    DEFF Research Database (Denmark)

    Pariente, Benjamin; Cosnes, Jacques; Danese, Silvio

    2011-01-01

    is to outline the methods to develop an instrument that can measure cumulative bowel damage. The project is being conducted by the International Program to develop New Indexes in Crohn's disease (IPNIC) group. This instrument, called the Crohn's Disease Digestive Damage Score (the Lémann score), should take...

  9. Obtaining cementitious material from municipal solid waste

    Directory of Open Access Journals (Sweden)

    Macías, A.

    2007-06-01

    Full Text Available The primary purpose of the present study was to determine the viability of using incinerator ash and slag from municipal solid waste as a secondary source of cementitious materials. The combustion products used were taken from two types of Spanish MSW incinerators, one located at Valdemingómez, in Madrid, and the other in Melilla, with different incineration systems: one with fluidised bed combustion and other with mass burn waterwall. The effect of temperature (from 800 to 1,200 ºC on washed and unwashed incinerator residue was studied, in particular with regard to phase formation in washed products with a high NaCl and KCl content. The solid phases obtained were characterized by X-ray diffraction and BET-N2 specific surface procedures.El principal objetivo del trabajo ha sido determinar la viabilidad del uso de las cenizas y escorias procedentes de la incineración de residuos sólidos urbanos, como materia prima secundaria para la obtención de fases cementantes. Para ello se han empleado los residuos generados en dos tipos de incineradoras españolas de residuos sólidos urbanos: la incineradora de Valdemingómez y la incineradora de Melilla. Se ha estudiado la transformación de los residuos, sin tratamiento previo, en función de la temperatura de calentamiento (desde 800 ºC hasta 1.200 ºC, así como la influencia del lavado de los residuos con alto contenido en NaCl y KCl en la formación de fases obtenidas a las diferentes temperaturas de calcinación. Las fases obtenidas fueron caracterizadas por difracción de rayos X y área superficial por el método BET-N2.

  10. Characterization of rough interfaces obtained by boriding

    Energy Technology Data Exchange (ETDEWEB)

    Campos-Silva, I. [Instituto Politecnico Nacional, SEPI-ESIME, U.P. Adolfo Lopez Mateos, Zacatenco, Mexico D.F. 07738 (Mexico)], E-mail: icampos@ipn.mx; Balankin, A.S. [Instituto Politecnico Nacional, SEPI-ESIME, U.P. Adolfo Lopez Mateos, Zacatenco, Mexico D.F. 07738 (Mexico); Sierra, A.H. [Instituto Politecnico Nacional, UPIICSA, Av. Te 950, Col Granjas, Mexico D.F. 08400 (Mexico); Lopez-Perrusquia, N. [Instituto Politecnico Nacional, SEPI-ESIME, U.P. Adolfo Lopez Mateos, Zacatenco, Mexico D.F. 07738 (Mexico); Escobar-Galindo, R. [Instituto de Ciencia de Materiales de Madrid (CSIC), Cantoblanco, Madrid E-28049 (Spain); Morales-Matamoros, D. [Instituto Mexicano del Petroleo, Eje Lazaro Cardenas Norte, Mexico D.F. 07738 (Mexico)

    2008-12-30

    This study evaluates the morphology of borided interfaces by means of the fractal theory. The boride layers were formed in the AISI M2 steel by applying the paste boriding treatment at temperatures of 1253 and 1273 K and treatment times of 2 and 6 h, while a boron carbide paste thickness of 4 or 5 mm covered the samples surface in order to produce the boron diffusion. The morphology of interfaces formed between FeB and Fe{sub 2}B layers and between Fe{sub 2}B layer and steel substrate was analyzed by the rescaled-range (R/S), root-mean-square (RMS), and Fourier power spectrum (FPS) methods. Moreover, the multi-affine spectra of roughness exponent were obtained by calculating the q-order height-height correlation functions. We found that both interfaces are multi-affine, rather than self-affine. The multi-affine spectra of roughness exponents are found to be different for FeB/Fe{sub 2}B and Fe{sub 2}B/substrate interfaces, but independent on the treatment parameters (boron carbide paste thickness, temperature, and boriding time). Furthermore, we found that the multi-affine spectra of both interfaces behave as it is expected for 'universal multi-fractals' with the Levy index {gamma} = 1, associated with the multiplicative cascades with a log-Cauchy distribution. Furthermore, our data suggest a great homogeneity of the boron diffusion field, characterized by universal fractal dimension D{sub diff} = 2.90 {+-} 0.01. These findings provide a novel insight into the nature of phase formation during the boriding treatment.

  11. [Validating the Spanish version of the Nursing Activities Score].

    Science.gov (United States)

    Sánchez-Sánchez, M M; Arias-Rivera, S; Fraile-Gamo, M P; Thuissard-Vasallo, I J; Frutos-Vivar, F

    2015-01-01

    Validating workload scores ensures that they are appropriate for the purpose for which they were developed. To validate the Nursing Activities Score (NAS) Spanish version. Observational and prospective study. 1,045 patients who were admitted to a medical-surgical unit and a serious burns unit in 2006 were included. The nurse in charge assessed patient workloads by Nine Equivalent of Nursing Manpower use Score and NAS. To assess the internal consistency of the measurements of NAS, item-test correlations, Cronbach's α and Cronbach's α corrected by omitting each of the items were calculated. The intraobserver and interobserver reliability were assessed with the intraclass correlation coefficient by viewing recordings and Kappa (interobserver reliability) was estimated. For the analysis of internal validity, a factorial principal components analysis was performed. Convergent validity was assessed using the Spearman correlation coefficient values obtained from the Nine Equivalent of Nursing Manpower use Score and Spanish-NAS scales. For internal consistency, 164 questionnaires were analysed and a Cronbach's α of 0.373 was calculated. The intraclass correlation coefficient for intraobserver reliability estimate was 0.837 (95% IC: 0.466-0.950) and 0.662 (95% IC: 0.033-0.882) for interobserver reliability. The estimated kappa was 0.371. For internal validity, exploratory factor analysis showed that the first item explained 58.9% of the variance of the questionnaire. For convergent validity 1006 questionnaires were included and a Spearman correlation coefficient of 0.746 was observed. The psychometric properties of Spanish-NAS are acceptable. Copyright © 2014 Elsevier España, S.L.U. y SEEIUC. All rights reserved.

  12. Homology model-based virtual screening for GPCR ligands using docking and target-biased scoring.

    Science.gov (United States)

    Radestock, Sebastian; Weil, Tanja; Renner, Steffen

    2008-05-01

    The current study investigates the combination of two recently reported techniques for the improvement of homology model-based virtual screening for G-protein coupled receptor (GPCR) ligands. First, ligand-supported homology modeling was used to generate receptor models that were in agreement with mutagenesis data and structure-activity relationship information of the ligands. Second, interaction patterns from known ligands to the receptor were applied for scoring and rank ordering compounds from a virtual library using ligand-receptor interaction fingerprint-based similarity (IFS). Our approach was evaluated in retrospective virtual screening experiments for antagonists of the metabotropic glutamate receptor (mGluR) subtype 5. The results of our approach were compared to the results obtained by conventional scoring functions (Dock-Score, PMF-Score, Gold-Score, ChemScore, and FlexX-Score). The IFS lead to significantly higher enrichment rates, relative to the competing scoring functions. Though using a target-biased scoring approach, the results were not biased toward the chemical classes of the reference structures. Our results indicate that the presented approach has the potential to serve as a general setup for successful structure-based GPCR virtual screening.

  13. CS-SCORE: Rapid identification and removal of human genome contaminants from metagenomic datasets.

    Science.gov (United States)

    Haque, Mohammed Monzoorul; Bose, Tungadri; Dutta, Anirban; Reddy, Chennareddy Venkata Siva Kumar; Mande, Sharmila S

    2015-08-01

    Metagenomic sequencing data, obtained from host-associated microbial communities, are usually contaminated with host genome sequence fragments. Prior to performing any downstream analyses, it is necessary to identify and remove such contaminating sequence fragments. The time and memory requirements of available host-contamination detection techniques are enormous. Thus, processing of large metagenomic datasets is a challenging task. This study presents CS-SCORE--a novel algorithm that can rapidly identify host sequences contaminating metagenomic datasets. Validation results indicate that CS-SCORE is 2-6 times faster than the current state-of-the-art methods. Furthermore, the memory footprint of CS-SCORE is in the range of 2-2.5GB, which is significantly lower than other available tools. CS-SCORE achieves this efficiency by incorporating (1) a heuristic pre-filtering mechanism and (2) a directed-mapping approach that utilizes a novel sequence composition metric (cs-score). CS-SCORE is expected to be a handy 'pre-processing' utility for researchers analyzing metagenomic datasets. For academic users, an implementation of CS-SCORE is freely available at: http://metagenomics.atc.tcs.com/cs-score (or) https://metagenomics.atc.tcs.com/preprocessing/cs-score. Copyright © 2015 Elsevier Inc. All rights reserved.

  14. Evaluation of a scoring system for assessing prognosis in pediatric acute liver failure.

    Science.gov (United States)

    Lu, Brandy R; Gralla, Jane; Liu, Edwin; Dobyns, Emily L; Narkewicz, Michael R; Sokol, Ronald J

    2008-10-01

    Pediatric acute liver failure (PALF) results in death or need for liver transplantation (LT) in up to 50% of patients. A scoring system for predicting death or LT (Liver Injury Units [LIU] score) in PALF was previously derived by our group, and used peak values during hospital admission of total bilirubin, prothrombin time/international normalized ratio, and ammonia as significant predictors of outcome. The aims of this study were to test the predictive value of the LIU score in a subsequent validation set of patients and to derive a hospital admission LIU (aLIU) score predictive of outcome. Data were obtained from 53 children admitted with PALF from 2002 to 2006. Outcome was defined at 16 weeks as alive without LT, death, or LT. Survival without LT at 16 weeks for each LIU score quartile was 92%, 44%, 60%, and 12%, respectively (P < .001). The receiver operating characteristic C index for predicting death or LT by 4 weeks was 86.3. An admission LIU score was derived using admission total bilirubin and prothrombin time/international normalized ratio. Survival without LT at 16 weeks for each quartile using the aLIU score was 85%, 77%, 69%, and 31% (P = .001). The receiver operating characteristic C index for predicting death or LT by 4 weeks was 83.7. The original LIU score is a valid predictor of outcome in PALF. The aLIU score is promising and needs to be validated in subsequent patients.

  15. Prostate cancer: Relationship between vascular diameter, shape and density and Gleason score in needle biopsy specimens.

    Science.gov (United States)

    Tadayyon, Farhad; Mellat, Mehdi; Alizadeh, Farshid; Hadi, Mazaher; Khorrami, Mohammadhatef; Yazdani, Mohammad; Joozdani, Rasoul Hashemi

    2013-01-01

    Tumor growth requires expansion and development of vascular network. An increase in Gleason score is representative of an increase in tumor invasion and extent. In this study, the relationship between Gleason score and vascular characteristics of needle biopsy samples in prostate cancer patients has been evaluated. We evaluated vascular characteristics including density and size of vessels; and percentage of vessels with irregular shape in 62 cancer-positive samples obtained by prostate needle biopsy under ultrasound guide, and compared them to Gleason score. Gleason scores of 23 patients were ≤6; Gleason scores of 18 patients were 7 and 21 patients had their Gleason score from 8 to 10. An increase in Gleason score was associated with increased vascular density (P Gleason score can prognosticate the behavioral characteristics of prostate cancer in future, vascular characteristics may also be able to express tumor behavior. With attention to vascular characteristics in biopsy samples and apart from Gleason score, we may also be able to divide patients into other subtypes in a way being helpful for the establishment of treatment plan.

  16. Development of a Traumatic Brain Injury Assessment Score Using Novel Biomarkers Discovered Through Autoimmune Profiling

    Science.gov (United States)

    2013-07-03

    detection LOQ: level of quantification M: molar mA: milliamp MALDI-TOF: matrix-assisted laser desorption/ionization-time of flight MANOV A...that the results were still robust to violations of the statistical assumptions (116). Therefore, a MANOV A analysis was utilized to determine how the

  17. The sociability score : App-based social profiling from a healthcare perspective

    NARCIS (Netherlands)

    Eskes, Paul; Spruit, Marco; Brinkkemper, Sjaak; Vorstman, Jacob|info:eu-repo/dai/nl/304817023; Kas, Martien J.|info:eu-repo/dai/nl/185967019

    2016-01-01

    As the smartphone becomes an integral part of our lives, its value as a rich data source reaches an increasing potential. Several previous studies have used smartphone-derived data to discover relationships between user characteristics and different types of smartphone use. However, none tried to

  18. The Sociability Score: App-based social profiling from a healthcare perspective

    NARCIS (Netherlands)

    Eskes, P.; Spruit, M.; Brinkkemper, S.; Vorstman, J.; Kas, M.

    2016-01-01

    As the smartphone becomes an integral part of our lives, its value as a rich data source reaches an increasing potential. Several previous studies have used smartphone-derived data to discover relationships between user characteristics and different types of smartphone use. However, none tried to

  19. PROFILER: 1D galaxy light profile decomposition

    Science.gov (United States)

    Ciambur, Bogdan C.

    2017-05-01

    Written in Python, PROFILER analyzes the radial surface brightness profiles of galaxies. It accurately models a wide range of galaxies and galaxy components, such as elliptical galaxies, the bulges of spiral and lenticular galaxies, nuclear sources, discs, bars, rings, and spiral arms with a variety of parametric functions routinely employed in the field (Sérsic, core-Sérsic, exponential, Gaussian, Moffat and Ferrers). In addition, Profiler can employ the broken exponential model (relevant for disc truncations or antitruncations) and two special cases of the edge-on disc model: namely along the major axis (in the disc plane) and along the minor axis (perpendicular to the disc plane).

  20. Generation of GHS Scores from TEST and online sources ...

    Science.gov (United States)

    Alternatives assessment frameworks such as DfE (Design for the Environment) evaluate chemical alternatives in terms of human health effects, ecotoxicity, and fate. T.E.S.T. (Toxicity Estimation Software Tool) can be utilized to evaluate human health in terms of acute oral rat toxicity, developmental toxicity, endocrine activity, and mutagenicity. It can be used to evaluate ecotoxicity (in terms of acute fathead minnow toxicity) and fate (in terms of bioconcentration factor). It also be used to estimate a variety of key physicochemical properties such as melting point, boiling point, vapor pressure, water solubility, and bioconcentration factor. A web-based version of T.E.S.T. is currently being developed to allow predictions to be made from other web tools. Online data sources such as from NCCT’s Chemistry Dashboard, REACH dossiers, or from ChemHat.org can also be utilized to obtain GHS (Global Harmonization System) scores for comparing alternatives. The purpose of this talk is to show how GHS (Global Harmonization Score) data can be obtained from literature sources and from T.E.S.T. (Toxicity Estimation Software Tool). This data will be used to compare chemical alternatives in the alternatives assessment dashboard (a 2018 CSS product).

  1. Simple new risk score model for adult cardiac extracorporeal membrane oxygenation: simple cardiac ECMO score.

    Science.gov (United States)

    Peigh, Graham; Cavarocchi, Nicholas; Keith, Scott W; Hirose, Hitoshi

    2015-10-01

    Although the use of cardiac extracorporeal membrane oxygenation (ECMO) is increasing in adult patients, the field lacks understanding of associated risk factors. While standard intensive care unit risk scores such as SAPS II (simplified acute physiology score II), SOFA (sequential organ failure assessment), and APACHE II (acute physiology and chronic health evaluation II), or disease-specific scores such as MELD (model for end-stage liver disease) and RIFLE (kidney risk, injury, failure, loss of function, ESRD) exist, they may not apply to adult cardiac ECMO patients as their risk factors differ from variables used in these scores. Between 2010 and 2014, 73 ECMOs were performed for cardiac support at our institution. Patient demographics and survival were retrospectively analyzed. A new easily calculated score for predicting ECMO mortality was created using identified risk factors from univariate and multivariate analyses, and model discrimination was compared with other scoring systems. Cardiac ECMO was performed on 73 patients (47 males and 26 females) with a mean age of 48 ± 14 y. Sixty-four percent of patients (47/73) survived ECMO support. Pre-ECMO SAPS II, SOFA, APACHE II, MELD, RIFLE, PRESERVE, and ECMOnet scores, were not correlated with survival. Univariate analysis of pre-ECMO risk factors demonstrated that increased lactate, renal dysfunction, and postcardiotomy cardiogenic shock were risk factors for death. Applying these data into a new simplified cardiac ECMO score (minimal risk = 0, maximal = 5) predicted patient survival. Survivors had a lower risk score (1.8 ± 1.2) versus the nonsurvivors (3.0 ± 0.99), P ECMO patients did not correlate with ECMO survival, whereas a new simplified cardiac ECMO score provides survival predictability. Copyright © 2015 Elsevier Inc. All rights reserved.

  2. The RIPASA score for the diagnosis of acute appendicitis: A comparison with the modified Alvarado score.

    Science.gov (United States)

    Díaz-Barrientos, C Z; Aquino-González, A; Heredia-Montaño, M; Navarro-Tovar, F; Pineda-Espinosa, M A; Espinosa de Santillana, I A

    2018-02-06

    Acute appendicitis is the first cause of surgical emergencies. It is still a difficult diagnosis to make, especially in young persons, the elderly, and in reproductive-age women, in whom a series of inflammatory conditions can have signs and symptoms similar to those of acute appendicitis. Different scoring systems have been created to increase diagnostic accuracy, and they are inexpensive, noninvasive, and easy to use and reproduce. The modified Alvarado score is probably the most widely used and accepted in emergency services worldwide. On the other hand, the RIPASA score was formulated in 2010 and has greater sensitivity and specificity. There are very few studies conducted in Mexico that compare the different scoring systems for appendicitis. The aim of our article was to compare the modified Alvarado score and the RIPASA score in the diagnosis of patients with abdominal pain and suspected acute appendicitis. An observational, analytic, and prolective study was conducted within the time frame of July 2002 and February 2014 at the Hospital Universitario de Puebla. The questionnaires used for the evaluation process were applied to the patients suspected of having appendicitis. The RIPASA score with 8.5 as the optimal cutoff value: ROC curve (area .595), sensitivity (93.3%), specificity (8.3%), PPV (91.8%), NPV (10.1%). Modified Alvarado score with 6 as the optimal cutoff value: ROC curve (area .719), sensitivity (75%), specificity (41.6%), PPV (93.7%), NPV (12.5%). The RIPASA score showed no advantages over the modified Alvarado score when applied to patients presenting with suspected acute appendicitis. Copyright © 2018 Asociación Mexicana de Gastroenterología. Publicado por Masson Doyma México S.A. All rights reserved.

  3. MRI bone oedema scores are higher in the arthritis mutilans form of psoriatic arthritis and correlate with high radiographic scores for joint damage

    Science.gov (United States)

    Tan, Yu M; Østergaard, Mikkel; Doyle, Anthony; Dalbeth, Nicola; Lobo, Maria; Reeves, Quentin; Robinson, Elizabeth; Taylor, William J; Jones, Peter B; Pui, Karen; Lee, Jamie; McQueen, Fiona M

    2009-01-01

    Introduction The aim of this study was to investigate the magnetic resonance imaging (MRI) features of bone disease in the arthritis mutilans (AM) form of psoriatic arthritis (PsA). Methods Twenty-eight patients with erosive PsA were enrolled (median disease duration of 14 years). Using x-rays of both hands and feet, 11 patients were classified as AM and 17 as non-AM (erosive psoriatic arthritis without bone lysis)by two observers. MRI scans (1.5T) of the dominant hand (wrist and fingers scanned separately) were obtained using standard contrast-enhanced T1-weighted and fat-saturated T2-weighted sequences. Scans were scored separately by two readers for bone erosion, oedema and proliferation using a PsA MRI scoring system. X-rays were scored for erosions and joint space narrowing. Results On MRI, 1013 bones were scored by both readers. Reliability for scoring erosions and bone oedema was high (intraclass correlation coefficients = 0.80 and 0.77 respectively) but only fair for bone proliferation (intraclass correlation coefficient = 0.42). MRI erosion scores were higher in AM patients (53.0 versus 15.0, p = 0.004) as were bone oedema and proliferation scores (14.7 versus 10.0, p = 0.056 and 3.6 versus 0.7, p = 0.003 respectively). MRI bone oedema scores correlated with MRI erosion scores and X-ray erosion and joint space narrowing scores (r = 0.65, p = 0.0002 for all) but not the disease activity score 28-C reactive protein (DAS28CRP) or pain scores. Conclusions In this patient group with PsA, MRI bone oedema, erosion and proliferation were all more severe in the AM-form. Bone oedema scores did not correlate with disease activity measures but were closely associated with X-ray joint damage scores. These results suggest that MRI bone oedema may be a pre-erosive feature and that bone damage may not be coupled with joint inflammation in PsA. PMID:19126234

  4. Component Repair Times Obtained from MSPI Data

    Energy Technology Data Exchange (ETDEWEB)

    Eide, Steven A. [Curtiss-Wright/Scietech, Ketchum, ID (United States); Cadwallader, Lee [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2015-05-01

    Information concerning times to repair or restore equipment to service given a failure is valuable to probabilistic risk assessments (PRAs). Examples of such uses in modern PRAs include estimation of the probability of failing to restore a failed component within a specified time period (typically tied to recovering a mitigating system before core damage occurs at nuclear power plants) and the determination of mission times for support system initiating event (SSIE) fault tree models. Information on equipment repair or restoration times applicable to PRA modeling is limited and dated for U.S. commercial nuclear power plants. However, the Mitigating Systems Performance Index (MSPI) program covering all U.S. commercial nuclear power plants provides up-to-date information on restoration times for a limited set of component types. This paper describes the MSPI program data available and analyzes the data to obtain median and mean component restoration times as well as non-restoration cumulative probability curves. The MSPI program provides guidance for monitoring both planned and unplanned outages of trains of selected mitigating systems deemed important to safety. For systems included within the MSPI program, plants monitor both train UA and component unreliability (UR) against baseline values. If the combined system UA and UR increases sufficiently above established baseline results (converted to an estimated change in core damage frequency or CDF), a “white” (or worse) indicator is generated for that system. That in turn results in increased oversight by the US Nuclear Regulatory Commission (NRC) and can impact a plant’s insurance rating. Therefore, there is pressure to return MSPI program components to service as soon as possible after a failure occurs. Three sets of unplanned outages might be used to determine the component repair durations desired in this article: all unplanned outages for the train type that includes the component of interest, only

  5. Effects of MMPI-2 and MMPI-A norms on T-score elevations for 18-year-olds.

    Science.gov (United States)

    Shaevel, B; Archer, R P

    1996-08-01

    This study examines the effects of scoring 18-year-old respondents on Minnesota Multiphasic Personality Inventory-2 (MMPI-2) and Minnesota Multiphasic Personality Inventory for Adolescents (MMPI-A) norms in terms of T-score elevations and profile configuration. Results indicate that substantial differences can occur in T-score elevations for 18-year-olds as a function of norms, with MMPI-2 norms generally producing lower validity scale values and higher clinical scale values than MMPI-A norms. These differences can range as high as 15 T-score points and resulted in different single-scale and 2-point profiles in 34% of the cases examined in this study.

  6. Integrated Test Scoring, Performance Rating and Assessment Records Keeping.

    Science.gov (United States)

    Cason, Gerald J.; And Others

    The Objective Test Scoring and Performance Rating (OTS-PR) system is a fully integrated set of 70 modular FORTRAN programs run on a VAX-8530 computer. Even with no knowledge of computers, the user can implement OTS-PR to score multiple-choice tests, include scores from external sources such as hand-scored essays or scores from nationally…

  7. Prognostic evaluation of patients undergoing living-donor liver transplant by APACHE II and MELD scores.

    Science.gov (United States)

    Zhang, Zheng-Yun; Chen, Rui; Zhou, Zun-Qiang; Peng, Cheng-Hong; Zhou, Guang-Wen

    2015-02-01

    We hypothesized that the combination of APACHE II and Model for End-Stage Liver Disease systems would work satisfactorily in patients admitted to intensive care unit after living-donor liver transplant. Data were retrospectively collected from the database of our surgical team. The study included 38 patients (hepatitis B virus cirrhosis, 47.4%; hepatocellular carcinoma, 28.9%; other diseases, 23.7%). Laboratory values were obtained. Vital signs, Glasgow Coma scale scores, and urine output were abstracted. Variables included age, sex, acute physiology score, APACHE II score, APACHE II-predicted intensive care unit and hospital mortality, predicted length of intensive care unit, and hospital stay. Patients' actual length of intensive care unit and hospital stays, intensive care unit and hospital discharge status, and discharge location were recorded. Standardized mortality ratios were calculated. Discrimination and calibration of APACHE II were assessed. All patients were divided into 3 groups: Model for End-Stage Liver Disease score: >25, 18 to 25, and APACHE II scores of survivors and non-survivors were 13.03 and 23.67. Mean risk of death was 7.05% and 25.07%. APACHE II scores and risk of death between survivors and non-survivors was significantly different (P APACHE II score and Model for End-Stage Liver Disease score in the receiving operating characteristic curve was 20 and 25. Patients with APACHE II scores greater than 20 or Model for End-Stage Liver Disease scores greater than 25 had higher predicted hospital mortality after living-donor liver transplant. The modified APACHE II model provides an accurate prognosis of patients receiving a living-donor liver transplant. The combined application of Model for End-Stage Liver Disease score and APACHE II score can improve the predictive accuracy.

  8. Impact of Moodle-Based Online Curriculum on Thoracic Surgery In-Training Examination Scores.

    Science.gov (United States)

    Antonoff, Mara B; Verrier, Edward D; Allen, Mark S; Aloia, Lauren; Baker, Craig; Fann, James I; Iannettoni, Mark D; Yang, Stephen C; Vaporciyan, Ara A

    2016-10-01

    The feasibility and efficacy of a web-based curriculum in supplementing thoracic surgical training was previously shown. However, the impact of curricular participation on validated knowledge tests remains unknown. We compared in-service training examination (ITE) results among trainees, stratified by curricular use. The national online curriculum was implemented in August 2013. We retrospectively reviewed trainees who participated in thoracic surgical training programs in both 2012 to 2013 and 2013 to 2014. Scores from the 2013 and 2014 ITEs were obtained, and curricular usage data were collected from site analytics. Trainees were separated into three groups according to 2013 ITE scores; within each group, changes in score for high- versus low-volume users were compared. 187 trainees took the ITE both years, with exposure to the online curriculum during only the second year. High-volume users' scores trended toward greater improvement than scores of low-volume users (+18.2% versus +13.0%, p = 0.199). When stratified by 2013 score, the lowest scoring quartile improved substantially, and the highest scoring quartile improved modestly, regardless of curricular use. However, for those individuals who achieved mid-range scores in 2013, there was a trend toward much greater improvement in score with heavier use of the curriculum (+17.0% versus +7.0%, p = 0.094). Among trainees who had access to the novel online curriculum during the second of 2 consecutive years, we evaluated the impact of curricular participation on ITE scores. The effect appears to be most pronounced in individuals with mid-range scores, in whom high curricular use led to the greatest improvement. Copyright © 2016 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved.

  9. Herman score in prenatal screening for Down syndrome: Can a junior assess a senior?

    Science.gov (United States)

    Hamdaoui, N; Lesieur, E; Mancini, J; Dabadie, A; Bourderionnet, V; Pico, H; Colombani, M; Bretelle, F; Gorincour, G

    2017-02-01

    To compare Herman scores self-assessed prospectively during ultrasound first-trimester screening by a single senior radiologist with 15 years of experience, to those obtained retrospectively by an unexperienced junior radiologist. Over a 18-month period, a single senior radiologist measured the nuchal translucency thickness along with calculation of Herman scores. An independent junior radiologist subsequently reviewed and scored the images. A total of 301 patients were included. The mean Herman score was 8.2±0.9 (SD) for the senior radiologist and 7.8±0.9 (SD) after review by the independent junior radiologist (PHerman score is lower after review by a junior radiologist, without any effect on patient's management and follow-up. Copyright © 2016 Éditions françaises de radiologie. Published by Elsevier Masson SAS. All rights reserved.

  10. Nursing Activities Score: nursing work load in a burns Intensive Care Unit

    Directory of Open Access Journals (Sweden)

    Marcia Bernadete Camuci

    2014-04-01

    Full Text Available OBJECTIVE: to evaluate the nursing work load in a Burns Intensive Care Unit according to the Nursing Activities Score.METHOD: an exploratory, descriptive cross-sectional study with a quantitative approach. The Nursing Activities Score was used for data collection between October 2011 and May 2012, totalling 1,221 measurements, obtained from 50 patients' hospital records. Data for qualitative variables was described in tables; for the quantitative variables, calculations using statistical measurements were used.RESULTS: the mean score for the Nursing Activities Score was 70.4% and the median was 70.3%, corresponding to the percentage of the time spent on direct care to the patient in 24 hours.CONCLUSION: the Nursing Activities Score provided information which involves the process of caring for patients hospitalized in a Burns Intensive Care Unit, and indicated that there is a high work load for the nursing team of the sector studied.

  11. Nursing Activities Score: nursing work load in a burns Intensive Care Unit.

    Science.gov (United States)

    Camuci, Marcia Bernadete; Martins, Júlia Trevisan; Cardeli, Alexandrina Aparecida Maciel; Robazzi, Maria Lúcia do Carmo Cruz

    2014-01-01

    to evaluate the nursing work load in a Burns Intensive Care Unit according to the Nursing Activities Score. an exploratory, descriptive cross-sectional study with a quantitative approach. The Nursing Activities Score was used for data collection between October 2011 and May 2012, totalling 1,221 measurements, obtained from 50 patients' hospital records. Data for qualitative variables was described in tables; for the quantitative variables, calculations using statistical measurements were used. the mean score for the Nursing Activities Score was 70.4% and the median was 70.3%, corresponding to the percentage of the time spent on direct care to the patient in 24 hours. the Nursing Activities Score provided information which involves the process of caring for patients hospitalized in a Burns Intensive Care Unit, and indicated that there is a high work load for the nursing team of the sector studied.

  12. Prolonged second stage of labor is associated with low Apgar score.

    Science.gov (United States)

    Altman, Maria; Sandström, Anna; Petersson, Gunnar; Frisell, Thomas; Cnattingius, Sven; Stephansson, Olof

    2015-11-01

    There is no consensus on the effects of a prolonged second stage of labor on neonatal outcomes. In this large Swedish population-based cohort study, our objective was to investigate prolonged second stage and risk of low Apgar score at 5 min. All nulliparous women (n = 32,796) delivering a live born singleton infant in cephalic presentation at ≥37 completed weeks after spontaneous onset of labor between 2008 and 2012 in the counties of Stockholm and Gotland were included. Data were obtained from computerized records. Exposure was time from fully retracted cervix until delivery. Logistic regression analyses were used to estimate crude and adjusted odds ratios (ORs) with 95% confidence intervals (CIs). Adjustments were made for maternal age, height, BMI, smoking, sex, gestational age, sex-specific birth weight for gestational age and head circumference. Epidural analgesia was included in a second model. The primary outcome measure was Apgar score at 5 min Apgar score Apgar score Apgar score.

  13. Analysis of Motivational Profiles of Satisfaction and Importance of Physical Education in High School Adolescents

    Science.gov (United States)

    Granero-Gallegos, Antonio; Baena-Extremera, Antonio; Pérez-Quero, Francisco J.; Ortiz-Camacho, Maria M.; Bracho-Amador, Clara

    2012-01-01

    The purpose of this study was to analyze the motivational profiles of satisfaction with and importance of physical education in high school students and its relation with gender and the practice of sport. The sample comprised 2002 students aged from 12 to 19 who completed the Sport Motivation Scale (Núñez et al., 2006), the Sport Satisfaction Instrument (Baena-Extremera et al., 2012) and the Importance of Physical Education Scale (Moreno et al., 2009). Descriptive analyzes, correlations between the scales, a cluster analysis for profiles, and a MANOVA were conducted to examine differences by gender. Three clusters (profiles) were identified. The first profile identified was "moderate" motivation (n = 463) and was associated with boys who practice physical activity for less than 3 hours per week. The second profile identified was "low" motivation (n = 545) and was associated mainly with girls who practice physical activity for less than 3 hours per week. And lastly the third profile identified was "high" motivation (n = 910), which was found to be greater in boys who practiced physical exercise for more than 3 hours a week. Key points High school students’ motivation was mainly intrinsic, scoring very low on a motivation and high on satisfaction/fun; equally, these students were task-oriented. There appears to be a positive relationship between intrinsic motivation and task-orientation in high school students. The subject of PE is considered very highly by the students, and hence it obtains high values on satisfaction/fun and is positively associated with the importance given to PE. PMID:24150070

  14. Right tail increasing dependence between scores

    Science.gov (United States)

    Fernández, M.; García, Jesús E.; González-López, V. A.; Romano, N.

    2017-07-01

    In this paper we investigate the behavior of the conditional probability Prob(U > u|V > v) of two records coming from students of an undergraduate course, where U is the score of calculus I, scaled in [0, 1] and V is the score of physics scaled in [0, 1], the physics subject is part of the admission test of the university. For purposes of comparison, we consider two different undergraduate courses, electrical engineering and mechanical engineering, during nine years, from 2003 to 2011. Through a Bayesian perspective we estimate Prob(U > u|V > v) year by year and course by course. We conclude that U is right tail increasing in V, in both courses and for all the years. Moreover, over these nine years, we observe different ranges of variability for the estimated probabilities of electrical engineering when compared to the estimated probabilities of mechanical engineering.

  15. Early warning scores: unravelling detection and escalation.

    Science.gov (United States)

    Smith, Gary B; Prytherch, David R; Meredith, Paul; Schmidt, Paul E

    2015-01-01

    The purpose of this paper is to increase understanding of how patient deterioration is detected and how clinical care escalates when early warning score (EWS) systems are used. The authors critically review a recent National Early Warning Score paper published in IJHCQA using personal experience and EWS-related publications, and debate the difference between detection and escalation. Incorrect EWS choice or poorly understood EWS escalation may result in unnecessary workloads forward and responding staff. EWS system implementers may need to revisit their guidance materials; medical and nurse educators may need to expand the curriculum to improve EWS system understanding and use. The paper raises the EWS debate and alerts EWS users that scrutiny is required.

  16. Scoring ultrasound synovitis in rheumatoid arthritis

    DEFF Research Database (Denmark)

    D'Agostino, Maria-Antonietta; Terslev, Lene; Aegerter, Philippe

    2017-01-01

    excellent for both binary and semiquantitative (SQ) grading but GS showed greater variability for both scoring systems (κ ranges: -0.05 to 1 and 0.59 to 0.92, respectively). In patient-based exercise, both intraobserver and interobserver reliability were variable and the mean κ coefficients did not reach 0...... and appearance of SH. CONCLUSION: A multistep consensus-based process has produced a standardised US definition and quantification system for RA synovitis including combined and individual SH and PD components. Further evaluation is required to understand its performance before application in clinical trials.......OBJECTIVES: To develop a consensus-based ultrasound (US) definition and quantification system for synovitis in rheumatoid arthritis (RA). METHODS: A multistep, iterative approach was used to: (1) evaluate the baseline agreement on defining and scoring synovitis according to the usual practice...

  17. The Dark Side of the Affective Profiles

    Directory of Open Access Journals (Sweden)

    Danilo Garcia

    2015-12-01

    Full Text Available The affective profiles model is based on the combination of individuals’ experience of high/low positive affect and high/low negative affect: self-fulfilling, high affective, low affective, and self-destructive. We used the profiles as the backdrop for the investigation of individual differences in malevolent character traits (i.e., the Dark Triad: psychopathy, Machiavellianism, and narcissism. A total of 1,000 participants (age: M = 31.50 SD = 10.27, 667 males and 333 females, recruited through Amazons’ Mechanical Turk (MTurk, responded to the Positive Affect Negative Affect Schedule and the Dark Triad Dirty Dozen. Individuals with a high affective profile reported higher degree of narcissism than those with any other profile, and together with individuals with a self-destructive profile, also higher degree of Machiavellianism and psychopathy than individuals with a low affective and self-fulfilling profile. Males scored higher in Machiavellianism and psychopathy. Together with earlier findings, our results show that while individuals in both the self-fulfilling and high affective profiles are extrovert and self-directed, only those in the high affective profile express an immature and malevolent character (i.e., high levels of all Dark Triad traits. Conversely, individuals in the self-fulfilling profile have earlier reported higher levels of cooperativeness and faith. More importantly, the unique association between high levels of positive emotions and narcissism and the unified association between negative emotions to both psychopathy and Machiavellianism imply a dyad rather than a triad of malevolent character traits.

  18. Parametric dependencies of JET electron temperature profiles

    Energy Technology Data Exchange (ETDEWEB)

    Schunke, B. [Commission of the European Communities, Abingdon (United Kingdom). JET Joint Undertaking; Imre, K.; Riedel, K. [New York Univ., NY (United States)

    1994-07-01

    The JET Ohmic, L-Mode and H-Mode electron temperature profiles obtained from the LIDAR Thomson Scattering Diagnostic are parameterized in terms of the normalized flux parameter and a set of the engineering parameters like plasma current, toroidal field, line averages electron density... It is shown that the electron temperature profiles fit a log-additive model well. It is intended to use the same model to predict the profile shape for D-T discharges in JET and in ITER. 2 refs., 5 figs.

  19. Aerodynamics profile not in stationary flow

    Directory of Open Access Journals (Sweden)

    А.А. Загорулько

    2006-02-01

    Full Text Available  Consider the question about influence of unsteady flight on the size of drag and lift coefficients of theaerodynamic profile. Distinctive features of this investigation are obtaining data about aerodynamic drag chancing in process unsteady on high angle at attack and oscillation profile in subsonic and transonic flight. Given analysis of oscillation profile show, that dynamic loops accompany change of lift and dray force. The researches show that it is necessary to clarity the mathematic model of the airplane flight dynamics by introducing numbers, with take into account unsteady effects.

  20. Augmented Interactive Scores for Music Creation

    OpenAIRE

    Fober, Dominique; Orlarey, Yann; Letz, Stéphane

    2014-01-01

    International audience; This article addresses music representation issues in the context of the contemporary music creation and performance. It exposes the main challenges in terms of music notation and representation, in regard of the new forms of music and with an emphasis on interactive music issues. It presents INScore, an environment for the design of augmented, interactive music scores that has been developed in response to current artistic evolutions. It gives an overview of the syste...