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Sample records for prof qiang fu

  1. Rama, Prof.

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1969 Section: Earth & Planetary Sciences. Rama, Prof. Ph.D. (Mumbai), FNA, FNAAS. Date of birth: 16 March 1929. Specialization: Isotope Hydrology Address: Y-4, Sector 9, CBD, Navi Mumbai 400 614, Maharashtra Contact: Residence: (022) 2757 0081. Email: rama.506@yahoo.

  2. Chokshi, Prof. Atul Harish

    Indian Academy of Sciences (India)

    Elected: 2005 Section: Engineering & Technology. Chokshi, Prof. Atul Harish ... Address: Department of Materials Engineering, Indian Institute of Science, Bengaluru 560 012, Karnataka Contact: ... Upcoming Refresher Courses. Topology

  3. Review and Reflection on the Religious Studies of the Qiang during the Past One Hundred Years

    Institute of Scientific and Technical Information of China (English)

    YUAN Linrong

    2014-01-01

    This article reviews more than 150 articles and books which research Qiang religion , and divides research of Qiang religioninto three pe-riods. Ⅰ.1910-1949:research on polytheistic be-liefs The period from 1910 to 1949 was a time dur-ing which Western anthropologists were searching for the Qiang ’ s religious culture .Characterisitc of this period was a bias towards descriptive eth-nography ;doing fieldwork related to religious cul-ture; and describing , recording or even recon-structing Qiang religious culture . Ⅱ.1950-1980: a time when fieldwork re-lated to religious customs stagnated From 1950 to 1980, almost all the research on the Qiang ’ s religious beliefs was based on the theoretical principle that “Religion is the opiate of the people”.We can see that all the works pro-duced during this period illustrated this principle . Ⅲ.1981 -2010: a period for investigation and sorting out the white stone belief system and scriptures 1.Research on the belief system of the white stone The representative work of this period was the Mysterious Worship of the White Stone by Wang Kang et al. in 1992. The authors transformed Qiang myths related to Heaven , Earth , nature , and hero into the origin of the religious belief sys-tem, and confirmed their social function .This pro-vided a new way of thinking in the studies on Qiang religion.In addition, there were archaeolog-ical interpretations regarding the study of the origin of the “white stone worship”. 2) Studies on religious rituals The Qiang between the Han and Tibetan by Wang Mingke discusses the relationship between the religious rituals and power , and the relation-ship between powers .It could be said that Wang Mingke ’ s research has expanded and deepened the vision of studies on the workshop of the moun-tain god. 3 ) Studies on community religion In the Study on Qiang History and Culture ed-ited by Lu Ding and Gong Tengyuan , there is a chapter that specially focuses on a discussion of Qiang

  4. Ramakrishnan, Prof. Tiruppattur Venkatachalamurti

    Indian Academy of Sciences (India)

    Ramakrishnan, Prof. Tiruppattur Venkatachalamurti. Elected: 1980 Section: Physics. Ramakrishnan, Prof. Tiruppattur Venkatachalamurti Ph.D. (Columbia), FNA, FNASc, FRS, FTWAS Council Service: 2004-2009; President 2004-2006. Date of birth: 14 August 1941. Specialization: Condensed Matter Physics and Statistical ...

  5. Prof. Ramakrishna Ramaswamy

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Ramaswamy, Prof. Ramakrishna. Elected: 1993 Section: Chemistry. Ramaswamy, Prof. Ramakrishna Ph.D. (Princeton), FNA, FTWAS Council Service: 2010-; Vice President & Editor of Publications: 2013-2015; President: 2016-. Date of birth: 14 October 1953. Specialization: Nonlinear ...

  6. Gopalakrishnan, Prof. Srinivasan

    Indian Academy of Sciences (India)

    Elected: 2013 Section: Engineering & Technology. Gopalakrishnan, Prof. Srinivasan Ph.D. (Purdue), FNAE. Date of birth: 25 June 1960. Specialization: Wave Propagation, Structural Health Monitoring, Computational Mechanics Address: Department of Aerospace Engineering, Indian Institute of Science, Bengaluru 560 012, ...

  7. Balakrishnan, Prof. Narayanaswamy

    Indian Academy of Sciences (India)

    Elected: 1994 Section: Engineering & Technology. Balakrishnan, Prof. Narayanaswamy Ph.D. (IISc), FNAE, FNA, FNASc, FTWAS ... Specialization: Numerical Electromagnetics, Information Security, Complex Networks, and Aerospace Electronic Systems Address: SERC, Indian Institute of Science, Bengaluru 560 012, ...

  8. Rao, Prof. Kaza Kesava

    Indian Academy of Sciences (India)

    Elected: 1992 Section: Engineering & Technology. Rao, Prof. ... Address: Professor, Department of Chemical Engineering, Indian Institute of Science, Bengaluru 560 012, Karnataka Contact: ... Upcoming Refresher Courses. Topology 02 to 14 ...

  9. Arakeri, Prof. Jaywant Hanumappa

    Indian Academy of Sciences (India)

    Elected: 2011 Section: Engineering & Technology. Arakeri, Prof. Jaywant Hanumappa Ph.D. (Caltech), FNAE. Date of birth: 15 November 1956. Specialization: Fluid Mechanics, Heat Transfer, Turbulence Address: Department of Mechanical Engineering, Indian Institute of Science, Bengaluru 560 012, Karnataka Contact:

  10. Yadav, Prof. Ganapati Dadasaheb

    Indian Academy of Sciences (India)

    Elected: 2017 Section: Engineering & Technology. Yadav, Prof. Ganapati Dadasaheb Ph.d. (Bombay). Date of birth: 14 September 1952. Specialization: Green Chemistry & Engineering, Catalysis Science & Engineering Address: Vice Chancellor, Institute of Chemical Technology, Matunga, Mumbai 400 019, Maharashtra

  11. Dhavale, Prof. Dilip Dattatray

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 2009 Section: Chemistry. Dhavale, Prof. Dilip Dattatray Ph.D. (Pune), FNASc. Date of birth: 18 February 1956. Specialization: Natural Products Chemistry, Carbohydrate Chemistry, Photochemistry, Reaction Mechanism, Medicinal Chemistry Address: Department of Chemistry, ...

  12. Kundu, Prof. Manikuntala

    Indian Academy of Sciences (India)

    , Prof. Manikuntala Ph.D. (Calcutta). Date of birth: 17 March 1958. Specialization: Stress Response in Mycobacterium Tuberculosis, Immunology of Host Cell Response to Helicobacter Pylori Address: Senior Professor, Department of Chemistry ...

  13. Inamdar, Prof. Maneesha Shreedhar

    Indian Academy of Sciences (India)

    Inamdar, Prof. Maneesha Shreedhar Ph.D. (Bombay). Date of birth: 25 February 1967. Specialization: Stem Cell Biology, Cardiovascular Development, Hematopoiesis & Angiogenesis Address: Molecular Biology & Genetics Unit, JN Centre for Advanced Scientific Research, Jakkur, Bengaluru 560 064, Karnataka Contact:

  14. [Herbological study of the botanical origin of Chinese crude drugs "Du-hua" and "Qiang-hua" in ancient China].

    Science.gov (United States)

    Mikage, Masayuki; Ochimori, Akane

    2007-01-01

    The Chinese crude drug Qiang-hua was listed as an alias of Du-hua in Shen-nong-ben-cao-jing, an herbal journal written during the Han Dynasty, China. Du-hua and Qiang-hua are recognized as different herbs in China these days; the main botanical origin of Du-hua is Angelica spp. and that of Qiang-hua is Notopterygium spp., of the family Umbelliferae. To make clear the botanical origins of Du-hua and Qiang-hua in ancient China, the authors made a herbological study. The findings were as follows: the name of Qiang-hua was given to the genuine Du-hua, which is produced in Qiang Province, an ancient province located in northwest China; the botanical origin of Qiang-hua is presumed to be Notopterygium incisum Ting ex H.T. Chang and N. forbesii Boissieu based on both the morphology and habitat written in ancient herbal journals. Both species are prescribed as having the plant origin of Qiang-hua in the present Chinese Pharmacopoeia. Therefore, we concluded that Du-hua and Qiang-hua were essentially the same drug, and were originally derived from the Notopterygium species in ancient China.

  15. FuNNy

    DEFF Research Database (Denmark)

    Madsen, Per Printz

    2005-01-01

    language, called FuNNy language) to C. The C learning library contains the learning algorithm. The generated C code is simple standard C and therefore it can be applied to all computers with a C-compiler. The learning algorithm is either a gradient descend method based on a numerical calculation...... of the gradient or a random search method. The input fuzzyfication can be described by four different kinds of membership functions. The output fuzzyfication is based on singletons. The rule base can be written in a natural language. The result of the learning is a new version of the fuzzy system described......The purpose of this paper is to describe a tool that is easy to use for implementing self learning fuzzy systems. This tool which is called FuNNy generates fuzzy systems. The tool consists of a compiler and a C learning library. The compiler translates a fuzzy system (written in a dedicated...

  16. The FU Orionis mechanism

    International Nuclear Information System (INIS)

    Larson, R.B.

    1980-01-01

    The large but temporary increase in radius accompanying the recurrent flare-ups of the FU Ori stars can be produced only by strong transient heating of a thin outer layer of the star. Simple composite polytropic models show that the observed changes in radius and luminosity can be accounted for if the outer 0.5 per cent of the mass gains a thermal energy comparable to the kinetic energy it would have in rapid rotation. The models also imply that the masses of the FU Ori stars are near 1 solar mass. The most plausible heating mechanism is an instability due to rapid rotation, and it is suggested that the secular instability of a convective rotating star to bar-like deformations is responsible; this will produce strong shocks, turbulence, and heating of the outermost layers of the star. Matter will also be ejected, and this could account for much of the mass and angular momentum lost from young stars. The most luminous T Tauri stars may have experienced recent FU Ori flare-ups and may still be a magnitude or more brighter than normal. (author)

  17. Ancient DNA reveals genetic connections between early Di-Qiang and Han Chinese.

    Science.gov (United States)

    Li, Jiawei; Zeng, Wen; Zhang, Ye; Ko, Albert Min-Shan; Li, Chunxiang; Zhu, Hong; Fu, Qiaomei; Zhou, Hui

    2017-12-04

    Ancient Di-Qiang people once resided in the Ganqing region of China, adjacent to the Central Plain area from where Han Chinese originated. While gene flow between the Di-Qiang and Han Chinese has been proposed, there is no evidence to support this view. Here we analyzed the human remains from an early Di-Qiang site (Mogou site dated ~4000 years old) and compared them to other ancient DNA across China, including an early Han-related site (Hengbei site dated ~3000 years old) to establish the underlying genetic relationship between the Di-Qiang and ancestors of Han Chinese. We found Mogou mtDNA haplogroups were highly diverse, comprising 14 haplogroups: A, B, C, D (D*, D4, D5), F, G, M7, M8, M10, M13, M25, N*, N9a, and Z. In contrast, Mogou males were all Y-DNA haplogroup O3a2/P201; specifically one male was further assigned to O3a2c1a/M117 using targeted unique regions on the non-recombining region of the Y-chromosome. We compared Mogou to 7 other ancient and 38 modern Chinese groups, in a total of 1793 individuals, and found that Mogou shared close genetic distances with Taojiazhai (a more recent Di-Qiang population), Hengbei, and Northern Han. We modeled their interactions using Approximate Bayesian Computation, and support was given to a potential admixture of ~13-18% between the Mogou and Northern Han around 3300-3800 years ago. Mogou harbors the earliest genetically identifiable Di-Qiang, ancestral to the Taojiazhai, and up to ~33% paternal and ~70% of its maternal haplogroups could be found in present-day Northern Han Chinese.

  18. Bhattacherjee, Prof. Satyendra Kumar

    Indian Academy of Sciences (India)

    Bhattacherjee, Prof. Satyendra Kumar Ph.D. (Notre Dame). Date of birth: 2 October 1926. Date of death: 28 April 2013. Specialization: Experimental Nuclear Physics Last known address: 302B, Tribute, Rajkamal Studio Compound, Off Dr SS Rao Road, Behind Mahatma Gandhi Memorial Hospital, Parel, Mumbai 400 012.

  19. Pandian, Prof. Thavamani Jegajothivel

    Indian Academy of Sciences (India)

    Elected: 1985 Section: Animal Sciences. Pandian, Prof. Thavamani Jegajothivel Ph.D. (Madras), Dr. rer. nat. (Kiel, Germany), FNA, FNASc, FNAAS, FTWAS, D.Sc. (CIFE, Mumbai). Date of birth: 15 June 1939. Specialization: Genetics and Energetics: Aquaculture Address: 9, Old Natham Road, Opp. Balamandiram, Madurai ...

  20. Maji, Prof. Tapas Kumar

    Indian Academy of Sciences (India)

    Elected: 2018 Section: Chemistry. Maji, Prof. Tapas Kumar Ph.D. (Jadavpur). Date of birth: 1 August 1974. Specialization: Porous Materials, Inorganic-Organic Hybrid nanomaterials, Molecule-based Magnetic& Optoelectronic Materials Address: Chemistry and Physics of Materials Unit, Jawaharlal Nehru Centre for ...

  1. Patel, Prof. Bhisma Kumar

    Indian Academy of Sciences (India)

    Elected: 2018 Section: Chemistry. Patel, Prof. Bhisma Kumar Ph.D. (IIT, Kanpur), FNASc. Date of birth: 6 August 1965. Specialization: Organic Synthesis, Reaction Mechanisms, Green Chemistry Address: Department of Chemistry, Indian Institute of Technology, Guwahati 781 039, Assam Contact: Office: (0361) 258 2307

  2. Chakraborty, Prof. Partha Sarathi

    Indian Academy of Sciences (India)

    Elected: 2018 Section: Mathematical Sciences. Chakraborty, Prof. Partha Sarathi Ph.D. (ISI), FNASc. Date of birth: 18 November 1973. Specialization: Operator Algebras, Noncommutative Geometry, Quantum Groups Address: The Institute of Mathematical Sciences, CIT Campus, Taramani, Chennai 600 113, T.N.. Contact:

  3. Ramachandran, Prof. Janakiraman

    Indian Academy of Sciences (India)

    Ramachandran, Prof. Janakiraman Ph.D. (UC, Berkeley). Date of birth: 12 June 1935. Specialization: Molecular Biology Address: Chairman, Gangagen Biotechnologies Private Limited, 12, 5th Cross, Raghavendra Layout, Tumkuar Road, Yeshwantpur, Bengaluru 560 022, Karnataka Contact: Office: (080) 4062 1300-328

  4. Narasimhan, Prof. Mudumbai Seshachalu

    Indian Academy of Sciences (India)

    Narasimhan, Prof. Mudumbai Seshachalu Ph.D. (Mumbai), FNA, FNASc, FRS Council Service: 1977-82; Vice-President: 1980-82. Date of birth: 7 June 1932. Specialization: Algebraic & Differential Geometry and Analysis Address: 9, Guruparadise Apartments, 24, 4th Main Road, Amarjyoti Layout, Sanjay Nagar, Bengaluru ...

  5. Bhosle, Prof. Ushadevi Narendra

    Indian Academy of Sciences (India)

    Bhosle, Prof. Ushadevi Narendra Ph.D. (Bombay), FNASc, FNA. Date of birth: 30 March 1949. Specialization: Algebraic Geometry Address: Flat No. 256, Jal Vayu Towers, NGEF Layout, Bennigannahalli, Bengaluru 560 038, Karnataka Contact: Residence: 99306 41136. Mobile: 88616 96296. Email: usnabh07@gmail.com.

  6. Menon, Prof. Thuppalay Kochugovinda

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 1974 Section: Physics. Menon, Prof. Thuppalay Kochugovinda Ph.D. (Harvard). Date of birth: 19 December 1928. Specialization: Astrophysics Address: 106-2803, 41st Avenue, Vancouver, British Columbia V6N 4B4, Canada Contact: Office: (+1-604) 822 0330. Residence: (+1-604) 266 1789

  7. Paulraj, Prof. Arogyaswami J

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 2014 Honorary. Paulraj, Prof. Arogyaswami J. Date of birth: 1944. Address: Information Systems Laboratory, Stanford University, 232, David Packard EE Building, 350, Serra Mall, Stanford, CA 94305-9510, USA Contact: Email: apaulraj@stanford.edu. YouTube; Twitter; Facebook ...

  8. Ojha, Prof. Devendra Kumar

    Indian Academy of Sciences (India)

    Elected: 2015 Section: Physics. Ojha, Prof. Devendra Kumar Ph.D. (Strasbourg). Date of birth: 23 August 1967. Specialization: Star Formation & Interstellar Medium, Infrared Astronomy, Astronomical Instrumentation Address: Department of Astronomy & Astrophysics, Tata Institute of Fundamental Research, Homi Bhabha ...

  9. Parulkar, Prof. Gurukumar Bhalchandra

    Indian Academy of Sciences (India)

    Parulkar, Prof. Gurukumar Bhalchandra M.S. (Mumbai), FAMS. Date of birth: 1 December 1931. Specialization: Open Heart Surgery, Extracorporeal Circulation, Coronary Bypass Surgery and Vascular Surgery Address: Flat No. 31, Building 4, Haji Ali Government Colony, K K Marg, Mumbai 400 034, Maharashtra Contact:

  10. Chakraborty, Prof. Ranajit

    Indian Academy of Sciences (India)

    Elected: 2006 Honorary. Chakraborty, Prof. Ranajit. Date of birth: 1946. Address: Director, Center for Computational Genomics, University of North Texas, HSC, 3500 Camp Bowie Blvd, CBH 249, Fort Worth, TX 76107, U.S.A.. Contact: Office: (+1-817) 735 2421. Fax: (+1-817) 735 5016. Email: ranajit.chakraborty@unthsc.

  11. Gopinathan, Prof. Karumathil Puthanveetil

    Indian Academy of Sciences (India)

    Elected: 1987 Section: General Biology. Gopinathan, Prof. Karumathil Puthanveetil Ph.D. (IISc), FNA, FNASc. Date of birth: 13 June 1939. Specialization: Molecular Biology, Recombinant DNA & Genetic Engineering, Molecular Virology, Biotechnology and Developmental Biology Address: Abhiman, 369, 11th Cross, II Block, ...

  12. Johri, Prof. Man Mohan

    Indian Academy of Sciences (India)

    Elected: 1983 Section: General Biology. Johri, Prof. Man Mohan Ph.D. (Delhi), FNA. Date of birth: 15 September 1940. Specialization: Plant Biochemistry, Molecular Biology of Plants and Genetic Engineering Address: Flat No. 32, New Cosmos CHSL, Juhu-Versova Link Road, Andheri (W), Mumbai 400 053, Maharashtra

  13. Govindarajan, Prof. Rama

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 2010 Section: Engineering & Technology. Govindarajan, Prof. Rama Ph.D. (IISc), FNASc. Date of birth: 26 August 1962. Specialization: Fluid Mechanics Address: International Centre for Theoretical Science, Shivakote, Hesaraghatta Post, Bengal;uru 560 089, Karnataka Contact:

  14. Kant, Prof. Rama

    Indian Academy of Sciences (India)

    Elected: 2015 Section: Chemistry. Kant, Prof. Rama Ph.D. (IISc). Date of birth: 18 January 1963. Specialization: Complex Systems in Electrochemistry & Polymers, Theoretical Chemistry, Nanoelectrochemistry Address: Department of Chemistry, University of Delhi, Delhi 110 007, U.T.. Contact: Office: (011) 2766 6646/188

  15. Lakhotia, Prof. Subhash Chandra

    Indian Academy of Sciences (India)

    Elected: 1994 Section: Animal Sciences. Lakhotia, Prof. Subhash Chandra Ph.D. (Calcutta), FNA, FNASc. Date of birth: 4 October 1945. Specialization: Ayurvedic Biology, Cytogenetics, Gene Expression, Stress Biology and Molecular Biology Address: INSA Senior Scientist, Department of Zoology, Banaras Hindu University ...

  16. Ramakrishna, Prof. Balakrishnan Siddartha

    Indian Academy of Sciences (India)

    Ramakrishna, Prof. Balakrishnan Siddartha MD, DM & Ph.D. (Madras), FAMS, FNA. Date of birth: 26 October 1952. Specialization: Gastroenterology, Nutrition, Inflammatory Bowel Disease, Gastrointestinal Microbiome Stem Cells Address: Flat No. 202-2-03, GVSPL Green Park, 342, Vaidyanathan Street, Nungambakkam, ...

  17. Abhyankar, Prof. Shreeram Shankar

    Indian Academy of Sciences (India)

    Abhyankar, Prof. Shreeram Shankar Ph.D. (Harvard), FNA. Date of birth: 22 July 1930. Date of death: 2 November 2012. Specialization: Algebra and Algebraic Geometry Last known address: Department of Mathematics, Purdue University, West Lafayette, Indiana 47907, USA. YouTube; Twitter; Facebook; Blog ...

  18. Lewis, Prof. Gilbert Newton

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1935 Honorary. Lewis, Prof. Gilbert Newton. Date of birth: 25 October 1875. Date of death: 24 March 1946. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year meeting of the Academy will be held ...

  19. Rao, Prof. Kalya Jagannatha

    Indian Academy of Sciences (India)

    Rao, Prof. Kalya Jagannatha Ph.D. (IIT, Kanpur), D.Sc. (IISc), FNA, FNASc, D.Sc. (h.c., Univ. Bordeaux, France) Council Service: 1998-2003. Date of birth: 7 December 1940. Specialization: Physical Chemistry of Amorphous Solids & Ceramics and Phase Transitions Address: 187/1, Tadvanam Estate, Halasinganahalli Road ...

  20. Jha, Prof. Sudhanshu Shekhar

    Indian Academy of Sciences (India)

    Jha, Prof. Sudhanshu Shekhar Ph.D. (Stanford), FNA, FNASc, FTWAS Council Service: 1989-94, Vice-President: 1989-91. Date of birth: 25 December 1940. Specialization: Solid State Theory, Quantum Computing and Photonics Address: 402, Vigyanshila, Juhu-Varsova Link Road, 7 Bungalows, Andheri (W), Mumbai 400 ...

  1. Ramachandran, Prof. Raghavan

    Indian Academy of Sciences (India)

    Ramachandran, Prof. Raghavan Ph.D. (Chicago), FNASc. Date of birth: 15 February 1940. Specialization: Particle Physics Address: Flat 12, Khagol Society, Panchvati, Pashan, Pune 411 008, Maharashtra Contact: Residence: (020) 6607 5892. Mobile: 94220 04597. Email: rr_1940@yahoo.co.in, rr@imsc.res.in. YouTube ...

  2. Cowsik, Prof. Ramanath

    Indian Academy of Sciences (India)

    Cowsik, Prof. Ramanath Ph.D. (Mumbai), FNA, FNASc, FTWAS. Date of birth: 29 August 1940. Specialization: Astrophysics, Elementary Particles Cosmology, Gravitation Address: Department of Physics, Washington University in St. Louis, Campus Box 1105, One Brookings Drive, St. Louis, MO 63130-4899, U.S.A.. Contact:

  3. Sarkar, Prof. Chitra

    Indian Academy of Sciences (India)

    Sarkar, Prof. Chitra M.B.B.S. (Bangalore), M.D. (AIIMS), FRC Path. (London), FNASc, FAMS, FNA Council Service: 2013-15. Date of birth: 11 September 1955. Specialization: Neuropathology Address: Professor, Department of Pathology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110 029, U.T.. Contact:

  4. Jayakrishnan, Prof. Athipettah

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 2001 Section: Engineering & Technology. Jayakrishnan, Prof. Athipettah Ph.D. (IIT, Chennai). Date of birth: 25 April 1953. Specialization: Polymer Chemistry, Biomaterials and Controlled Drug Delivery Address: Department of Biotechnology, Indian Institute of Technology, Chennai 600 036, T.N.

  5. Shashidhara, Prof. Lingadahalli Subrahmanya

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 2007 Section: Animal Sciences. Shashidhara, Prof. Lingadahalli Subrahmanya Ph.D. (Cambridge), FNA, FNASc. Date of birth: 23 March 1963. Specialization: Developmental Biology, Evolution and Genetics Address: Indian Institute of Science Education and Research (IISER), Dr Homi Bhabha Road, ...

  6. Sane, Prof. Sanjay Prafullachandra

    Indian Academy of Sciences (India)

    Sane, Prof. Sanjay Prafullachandra Ph.D. (Univ. Calif., Berkeley). Date of birth: 12 September 1970. Specialization: Neuroethology, Biomechanics, Fluid Mechanics Address: National Centre for Biological Sciences, GKVK Campus, Bengaluru 560 065, Karnatka Contact: Office: (080) 2366 7020. Residence: (080) 4097 0586

  7. Anderson, Prof. Basil Williams

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1964 Honorary. Anderson, Prof. Basil Williams. Date of birth: 3 July 1901. Date of death: 24 February 1984. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year meeting of the Academy will be held ...

  8. Pauling, Prof. Linus Carl

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1949 Honorary. Pauling, Prof. Linus Carl Nobel Laureate (Chemistry) - 1954; Peace - 1962. Date of birth: 28 February 1901. Date of death: 19 August 1994. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th ...

  9. Murty, Prof. Budharaju Srinivasa

    Indian Academy of Sciences (India)

    Murty, Prof. Budharaju Srinivasa Ph.D. (IISc), FNA, FNAE, FNASc. Date of birth: 13 February 1964. Specialization: High Entropy Alloys, Nanocrystalline Materials, Bulk Metallic Gases, In-situ Composites, Nonequilibrium Processing Address: Department of Metallurgical & Materials Engineering, Indian Institute of Technology, ...

  10. Chakrabarti, Prof. Partha Pratim

    Indian Academy of Sciences (India)

    Elected: 2000 Section: Engineering & Technology. Chakrabarti, Prof. Partha Pratim Ph.D. (IIT, Kharagpur), FNA, FNAE. Date of birth: 1 October 1962. Specialization: Artificial Intelligence, Computer Aided Design for VLSI and Algorithms Address: Director, Indian Institute of Technology, Kharagpur 721 302, W.B.. Contact:

  11. Padmanaban, Prof. Govindarajan

    Indian Academy of Sciences (India)

    Padmanaban, Prof. Govindarajan Ph.D. (IISc), FNA, FNASc, FTWAS Council Service: 1986-88, 1992-97; Vice-President: 1992-97. Date of birth: 20 March 1938. Specialization: Molecular Biology, Recombinant DNA and Malarial Parasite Address: NASI Senior Scientist, Department of Biochemistry, Indian Institute of Science, ...

  12. Lawrence, Prof. Ernest Orlando

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1954 Honorary. Lawrence, Prof. Ernest Orlando Nobel Laureate (Physics) - 1939. Date of birth: 8 August 1901. Date of death: 27 August 1958. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

  13. Sharma, Prof. Shobhona

    Indian Academy of Sciences (India)

    Sharma, Prof. Shobhona Ph.D. (Mumbai), FNA. Date of birth: 5 February 1953. Specialization: Molecular Parasitology, Parasite Immunology and Parasite Metabolism Address: Senior Professor & Chairperson, Department of Biological Sciences, Tata Institute of Fundamental Research, Homi Bhabha Road, Mumbai 400 005, ...

  14. Balaji, Prof. Kithiganahalli Naranayaswamy

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 2016 Section: General Biology. Balaji, Prof. Kithiganahalli Naranayaswamy Ph.D. (IISc), FNASc, FNA. Date of birth: 7 March 1966. Specialization: Immunology, Infectious Diseases Address: Department of Microbiology & Cell Biology, Indian Institute of Science, Bengaluru 560 012, Karnataka Contact:

  15. Das, Prof. Gobardhan

    Indian Academy of Sciences (India)

    Das, Prof. Gobardhan Ph.D. (Imtech), FNASc. Date of birth: 10 December 1966. Specialization: Immunology, Infectious Diseases, Cell Biology Address: Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi 110 067, U.T.. Contact: Office: (011) 2670 4559, 2673 8824. Residence: (0124) 424 2351

  16. Ramakrishnan, Prof. Palayanoor Sivaswamy

    Indian Academy of Sciences (India)

    Ramakrishnan, Prof. Palayanoor Sivaswamy Ph.D. (Banaras), FNA, FNASc, FTWAS. Date of birth: 24 December 1936. Specialization: Socio-ecology, Environment and Sustainable Development Address: INSA Honorary Scientist, School of Environmental Sciences, Jawaharlal Nehru University, New Delhi 110 067, U.T.

  17. Chakraborti, Prof. Asit Kumar

    Indian Academy of Sciences (India)

    Chakraborti, Prof. Asit Kumar Ph.D. (Jadavpur). Date of birth: 15 August 1954. Specialization: Synthetic Organic Chemistry, Green Chemistry, Medicinal Chemistry Address: Head, Department of Medicinal chemistry, National Institute of Pharmaceutical Education & Research, Sector 67, SAS Nagar 160 062, Panjab Contact:

  18. Kaliappan, Prof. Krishna Pillai

    Indian Academy of Sciences (India)

    Elected: 2016 Section: Chemistry. Kaliappan, Prof. Krishna Pillai Ph.D. (IISc). Date of birth: 16 March 1968. Specialization: Organic Synthesis, Medicinal Chemistry, Natural Products Address: Department of Chemistry, Indian Institute of Technology, Powai, Mumbai 400 076, Maharashtra Contact: Office: (022) 2576 7177

  19. Ila, Prof. Hiriyakkanavar

    Indian Academy of Sciences (India)

    Elected: 1991 Section: Chemistry. Ila, Prof. Hiriyakkanavar Ph.D. (IIT, Kanpur), FNA. Date of birth: 11 September 1944. Specialization: Synthetic Organic Chemistry, Heterocyclic Chemistry, Medicinal Chemistry Address: Apt. 002, Block VIII, Heritage Estate, Doddaballapur Road, Yelahanka, Bengaluru 560 064, Karnataka

  20. Bose, Prof. Arup

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 2006 Section: Mathematical Sciences. Bose, Prof. Arup Ph.D. (ISI, Calcutta), FNA, FNASc. Date of birth: 1 April 1959. Specialization: Probability and Statistics, Economics Address: Professor, Statistics & Mathematics Unit, Indian Statistical Institute, 203, B.T. Road, Kolkata 700 108, ...

  1. Kapur, Prof. Prakash Chand

    Indian Academy of Sciences (India)

    Elected: 1988 Section: Engineering & Technology. Kapur, Prof. Prakash Chand Ph.D. (UC, Berkeley), FNAE. Date of birth: 3 July 1935. Specialization: Mineral Processing, Particulate Science & Technology, Mathematical Modelling and Waste Management Address: R-485, New Rajinder Nagar, New Delhi 110 060, U.T.

  2. Nath, Prof. Girishwar

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 1981 Section: Mathematical Sciences. Nath, Prof. Girishwar Ph.D. (Budapest). Date of birth: 17 July 1932. Specialization: Fluid Mechanics, Magnetohydrodynamics and Turbomachines Address: c/o Dr S.K. Sinha, Type IV/17, KNIT Campus, Kamala Nehru Institute of, Technology, Sultanpur 228 118, ...

  3. Sarkar, Prof. Sabyasachi

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1997 Section: Chemistry. Sarkar, Prof. Sabyasachi Ph.D. (Gorakhpur). Date of birth: 17 May 1947. Specialization: Graphene & Carbon Quantum Dots, Drug Delivery, Bio-geoinorganic Chemistry, Structure-functional analogues of metallo-proteins, Carbon Quantum Dots, Bio- ...

  4. Yadav, Prof. Veejendra Kumar

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 2007 Section: Chemistry. Yadav, Prof. Veejendra Kumar Ph.D. (Baroda). Date of birth: 13 June 1956. Specialization: Synthetic Organic Chemistry and Physical Organic Chemistry Address: Professor, Department of Chemistry, Indian Institute of Technology, Kanpur 208 016, U.P.

  5. Mukherjee, Prof. Rabindra Nath

    Indian Academy of Sciences (India)

    Mukherjee, Prof. Rabindra Nath Ph.D. (Calcutta), FNA. Date of birth: 19 April 1953. Specialization: Bioinorganic Chemistry Address: Dept. of Chemistry, Indian Institute of Technology, Kanpur 208 016, U.P.. Contact: Mobile: 98308 39343. Email: rnm@iitk.ac.in, rnath.mukherjee@gmail.com. http://home.iitk.ac.in/~rnm.

  6. Mittal, Prof. Sanjay

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 2007 Section: Engineering & Technology. Mittal, Prof. Sanjay Ph.D. (Minnesota), FNAE, FNA, FNASc. Date of birth: 27 February 1968. Specialization: Unsteady Aerodynamics, Finite Element Analysis, High Performance Computing and Bluff-body Flows, Aerodynamic Shape ...

  7. Sarkar, Prof. Utpal

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 2008 Section: Physics. Sarkar, Prof. Utpal Ph.D. (Calcutta), FNA, FNASc. Date of birth: 15 May 1956. Specialization: Particle & Astroparticle Physics Address: Visiting Professor, Indian Institute of Technology, Kharagpur 721 302, W.B.. Contact: Mobile: 98985 86326

  8. Pandit, Prof. Aniruddha Bhalachandra

    Indian Academy of Sciences (India)

    Pandit, Prof. Aniruddha Bhalachandra Ph.D. (Mumbai), FNAE, FNA, FNASc, FTWAS. Date of birth: 7 December 1957. Specialization: Design of Multiphase Reactors, Cavitation Phenomena and Environmental & Energy Engineering Address: Dean (HR), Institute of Chemical Technology, N.P. Marg, Matunga, Mumbai 400 ...

  9. Kumar, Prof. Anurag

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 2010 Section: Engineering & Technology. Kumar, Prof. Anurag Ph.D. (Cornell), FNA, FNAE, FIEEE, FTWAS. Date of birth: 13 July 1955. Specialization: Wireless Networks, Communication Networks, Stochastic Modelling, Analysis & Optimisation of Distributed Systems Address: Director, Indian Institute ...

  10. Bapat, Prof. Ravindra Bhalchandra

    Indian Academy of Sciences (India)

    Elected: 2000 Section: Mathematical Sciences. Bapat, Prof. Ravindra Bhalchandra Ph.D. (Illinois), FNA. Date of birth: 20 December 1954. Specialization: Combinatorial Linear Algebra and Generalised Inverses Address: Statistics & Mathematics Unit, Indian Statistical Institute, 7, SJS Sansanwal Marg, New Delhi 110 016, ...

  11. Balasubramanian, Prof. Ramachandran

    Indian Academy of Sciences (India)

    Elected: 1987 Section: Mathematical Sciences. Balasubramanian, Prof. Ramachandran Ph.D. (Mumbai), FNA, FNASc. Council Service: 2007-2009. Date of birth: 15 March 1951. Specialization: Analytic Number Theory Address: Professor, The Institute of Mathematical Sciences, CIT Campus, Taramani, Chennai 600 113, ...

  12. Rao, Prof. Sumathi

    Indian Academy of Sciences (India)

    Rao, Prof. Sumathi Ph.D. (SUNY, Stony Brook), FNASc. Date of birth: 5 December 1956. Specialization: Theoretical Condensed Matter Physics, Quantum field Theory Address: Harish Chandra Research Institute, Chhatnag Road, Jhusi, Allahabad 211 019, U.P.. Contact: Office: (0532) 227 4303. Residence: (0532) 227 4002

  13. Ghosh, Prof. Pradyut

    Indian Academy of Sciences (India)

    Ghosh, Prof. Pradyut Ph.D. (IIT, Kanpur). Date of birth: 17 February 1970. Specialization: Chemical Sensing of Ions, Anion & Ion Pair Recognition Chemistry, Interlocked Molecular Systems & Self-Assembly Address: Department of Inorganic Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700 ...

  14. Chakravorty, Prof. Animesh

    Indian Academy of Sciences (India)

    Elected: 1975 Section: Chemistry. Chakravorty, Prof. Animesh Ph.D. (Calcutta), FNA, FTWAS Council Service: 1986-91. Date of birth: 30 June 1935. Specialization: Inorganic Chemistry Address: Flat 8/3, 6, Sunny Park, Ballygunge, Kolkata 700 019, W.B.. Contact: Residence: (033) 2485 8327. Mobile: 94338 01715

  15. Khorana, Prof. Har Gobind

    Indian Academy of Sciences (India)

    Elected: 1976 Honorary. Khorana, Prof. Har Gobind Nobel Laureate (Medicine) - 1968. Date of birth: 9 January 1922. Date of death: 9 November 2011. Last known address: Alfred P. Sloan Professor of, Biology and Chemistry, Massachusetts Institute of, Technology, 77 Massachusetts Ave., Cambridge, MA 02139, U.S.A..

  16. Gopinathan, Prof. Melethil Sankaran

    Indian Academy of Sciences (India)

    Elected: 1988 Section: Chemistry. Gopinathan, Prof. Melethil Sankaran Ph.D. (IIT, Kanpur), FNA. Date of birth: 8 October 1942. Specialization: Quantum Chemistry and Nonlinear Dynamics in Chemistry & Biology Address: Professor Emeritus, Indian Institute of Science Education & Research, Vithura, Thiruvananthapuram ...

  17. Chattaraj, Prof. Pratim Kumar

    Indian Academy of Sciences (India)

    Elected: 2001 Section: Chemistry. Chattaraj, Prof. Pratim Kumar Ph.D. (IIT, Mumbai), FNA, FNASc, FTWAS. Date of birth: 26 April 1958. Specialization: Hydrogen Storage, Density Functional Theory, Nonlinear Dynamics and Chemical Reactivity, Aromaticity in Metal Clusters Address: Department of Chemistry, Indian Institute ...

  18. Mahadevan, Prof. Priya

    Indian Academy of Sciences (India)

    Elected: 2014 Section: Physics. Mahadevan, Prof. Priya Ph.D. (IISc). Date of birth: 19 August 1970. Specialization: Electronic Structure of Materials, Magnetism, Nanostructure Materials Address: Associate Professor, SN Bose National Centre for Basic Sciences, JD Block, Sector 3, Salt Lake, Kolkata 700 098, W.B.. Contact:

  19. Kamal, Prof. Aditya Kumar

    Indian Academy of Sciences (India)

    Elected: 1974 Section: Engineering & Technology. Kamal, Prof. Aditya Kumar Dr. lng. (Paris). Date of birth: 5 July 1927. Specialization: Air Traffic Control, Surveillance, Automation, UAV, GPS, Cyber Security Address: 18, Crystal Circle, Burlington, MA 01803, USA Contact: Office: (+1-781) 890 3330/235. Residence: (+1-781) ...

  20. Dutta, Prof. Pradip

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 2012 Section: Engineering & Technology. Dutta, Prof. Pradip Ph.D. (Columbia), FNAE, FNASc, FNA. Date of birth: 2 October 1960. Specialization: Heat Transfer, Energy Studies Address: Department of Mechanical Engineering, Indian Institute of Science, Bengaluru 560 012, Karnataka Contact:

  1. Viswanadham, Prof. Nukala

    Indian Academy of Sciences (India)

    Viswanadham, Prof. Nukala Ph.D. (IISc), FNA, FTWAS, FNAE Council Service: 1992-97; Secretary: 1992-97. Date of birth: 9 November 1943. Specialization: Business Models, Blockchain & Supply Chain Networks Address: INSA Senior Scientist, CSA Department, Indian Institute of Science, Bengaluru 560 012, Karnataka

  2. Heyrovsky, Prof. Jaroslav

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1959 Honorary. Heyrovsky, Prof. Jaroslav Nobel Laureate (Chemistry) - 1959. Date of birth: 20 December 1890. Date of death: 27 March 1967. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

  3. Tyagi, Prof. Anil Kumar

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1995 Section: General Biology. Tyagi, Prof. Anil Kumar Ph.D. (Delhi), FNASc, FNA. Date of birth: 2 April 1951. Specialization: Molecular Biology, Biochemistry and Microbiology Address: Vice Chancellor, Guru Gobind Singh Indraprastha University, Sector 16C, Dwaraka, New Delhi ...

  4. Dodson, Prof. George Guy

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 2003 Honorary. Dodson, Prof. George Guy FRS. Date of birth: 13 January 1937. Date of death: 24 December 2012. Last known address: Division of Protein Structure, National Institute for Medical, Research, Mill Hill, London NW7 1AA, U.K.. YouTube; Twitter; Facebook; Blog ...

  5. Prof. Maitra, Uday (Secretary)

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1998 Section: Chemistry. Maitra, Prof. Uday Ph.D. (Columbia), FNA Council Service: 2013-; Secretary: 2013-. Date of birth: 8 November 1957. Specialization: Photoluminescent Sensors, Chemistry of Bile Acids, Organo & Hydrogels, Soft Composite Materials Address: Professor ...

  6. Series, Prof. George William

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1984 Honorary. Series, Prof. George William. Date of birth: 22 February 1920. Date of death: 2 January 1995. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year meeting of the Academy will be held ...

  7. Cotton, Prof. Frank Albert

    Indian Academy of Sciences (India)

    ... Lecture Workshops · Refresher Courses · Symposia · Live Streaming. Home; Fellowship. Fellow Profile. Elected: 1985 Honorary. Cotton, Prof. Frank Albert. Date of birth: 9 April 1930. Date of death: 20 February 2007. Last known address: Department of Chemistry, Texas A & M University, College Station, TX 77843, U.S.A..

  8. Hess, Prof. Walter Rudolf

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1966 Honorary. Hess, Prof. Walter Rudolf Nobel Laureate (Medicine) - 1949. Date of birth: 17 March 1881. Date of death: 12 August 1973. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year meeting ...

  9. Hill, Prof. Archibald Vivian

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1935 Honorary. Hill, Prof. Archibald Vivian Nobel Laureate (Medicine) - 1922. Date of birth: 26 September 1886. Date of death: 3 June 1977. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

  10. Granit, Prof. Ragnar Arthur

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1964 Honorary. Granit, Prof. Ragnar Arthur Nobel Laureate (Medicine) - 1967. Date of birth: 30 October 1900. Date of death: 11 March 1991. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

  11. Robinson, Prof. Robort

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1935 Honorary. Robinson, Prof. Robort Nobel Laureate (Chemistry) - 1947. Date of birth: 13 September 1886. Date of death: 8 February 1975. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

  12. Bose, Prof. Indrani

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 2000 Section: Physics. Bose, Prof. Indrani Ph.D. (Calcutta), FNASc. Date of birth: 15 August 1951. Specialization: Theoretical Condensed Matter Physics, Statistical Physics, Biological Physics and Systems Biology Address: Emeritus Scientist, Department of Physics, Bose Institute, ...

  13. Morgan, Prof. Thomas Hunt

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1939 Honorary. Morgan, Prof. Thomas Hunt Nobel Laureate (Medicine) - 1933. Date of birth: 25 September 1866. Date of death: 4 December 1945. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th ...

  14. Sarma, Prof. Dipankar Das

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1993 Section: Chemistry. Sarma, Prof. Dipankar Das Ph.D. (IISc), FNA, FNASc, FTWAS Council Service: 2016-. Date of birth: 15 September 1955. Specialization: Strongly Interacting Electron Systems, Disordered Systems, Nanomaterials and Energy Materials Address: Professor ...

  15. Ruzicka, Prof. Leopold Stephen

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1957 Honorary. Ruzicka, Prof. Leopold Stephen Nobel Laureate (Chemistry) - 1939. Date of birth: 13 September 1887. Date of death: 26 September 1976. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th ...

  16. Bajpai, Prof. Sunil

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 2007 Section: Earth & Planetary Sciences. Bajpai, Prof. Sunil Ph.D. (Panjab), FNASc. Council Service: 2016-. Date of birth: 30 September 1961. Specialization: Vertebrate Paleontology, Biostratigraphy and Paleobiogeography Address: Director, Birbal Sahni Institute of ...

  17. Antia, Prof. Hormazad Maneck

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1999 Section: Physics. Antia, Prof. Hormazad Maneck Ph.D. (Mumbai), FNA,. Date of birth: 6 November 1955. Specialization: Solar Physics, Helioseismology and Numerical Techniques Address: Professor, Astrophysics Group, Tata Institute of Fundamental Research, Homi Bhabha ...

  18. Iyengar, Prof. Rangachar Narayana

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1990 Section: Engineering & Technology. Iyengar, Prof. Rangachar Narayana Ph.D. (IISc), FNASc, FNAE. Date of birth: 2 June 1943. Specialization: Structural Dynamics, Earthquake Engineering, Applied Stochastics and History of Science Address: Centre for Advanced Research ...

  19. Lohia, Prof. Anuradha

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 2007 Section: General Biology. Lohia, Prof. Anuradha Ph.D. (Calcutta) Council Service: 2010-12. Date of birth: 11 June 1956. Specialization: Cell Cycle of Protozoan Parasite, Molecular Genetics & Genomics and Regulation of Gene Expression Address: Vice Chancellor ...

  20. Prof. Rengaswamy Ramesh

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 2001 Section: Earth & Planetary Sciences. Ramesh, Prof. Rengaswamy Ph.D. (Gujarat), FNA, FNASc, FTWAS Council Service: 2016 - April 2018. Date of birth: 2 June 1956. Date of death: 2 April 2018. Specialization: Palaeoclimatology & Climate Modelling, Mass Spectrometry, ...

  1. Kumar, Prof. Lalit

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 2010 Section: Medicine. Kumar, Prof. Lalit MD (Agra), DM (Madras), FAMS, FNASc. Council Service: 2016-. Date of birth: 30 June 1957. Specialization: Stem Cell Transplantation, Multiple Myeloma, Haemato-Oncology, Gynaecologic Oncology Address: Head, Department of ...

  2. Khakhar, Prof. Devang Vipin

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1996 Section: Engineering & Technology. Khakhar, Prof. Devang Vipin Ph.D. (Massachusetts), FNA, FNAE, FNASc. Council Service: 2010-12. Date of birth: 7 April 1959. Specialization: Granular Flow & Mixing, Polymer Processing Address: Director, Indian Institute of Technology, ...

  3. Balaram, Prof. Hemalatha

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 2009 Section: General Biology. Balaram, Prof. Hemalatha Ph.D. (IISc). Date of birth: 27 October 1956. Specialization: Molecular Enzymology, Molecular Parasitology and Protein Engineering Address: Molecular Biology & Genetics Unit, Jawaharlal Nehru Centre for Advanced ...

  4. Meyer, Prof. Kurt H.

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1952 Honorary. Meyer, Prof. Kurt H. Date of birth: 29 September 1883. Date of death: 14 April 1952. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year meeting of the Academy will be held from ...

  5. Gadre, Prof. Shridhar Ramchandra

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 1991 Section: Chemistry. Gadre, Prof. Shridhar Ramchandra Ph.D. (IIT, Kanpur), FNA. Date of birth: 20 May 1950. Specialization: Quantum Chemistry and Computer Applications Address: Interdisciplinary School of Scientific Computing, University of Pune, Ganeshkhind, Pune 411 007, Maharashtra

  6. Venkataraman, Prof. Chandra

    Indian Academy of Sciences (India)

    Elected: 2018 Section: Earth & Planetary Sciences. Venkataraman, Prof. Chandra Ph.D. (Univ. Calif., Los Angeles), FNAE, FNASc. Date of birth: 3 June 1963. Specialization: Aerosol Science & Engineering, Environmental & Climate Science, Atmospheric Science Address: Department of Chemical Engineering, Indian ...

  7. Mohan Kumar, Prof. Neithalath

    Indian Academy of Sciences (India)

    Elected: 1993 Section: Mathematical Sciences. Mohan Kumar, Prof. Neithalath Ph.D. (Mumbai). Date of birth: 12 May 1951. Specialization: Commutative Algebra and Algebraic Geometry Address: Department of Mathematics, Washington University at St. Louis, One Brookings Drive, Campus Box 1146, St. Louis, MO 63130, ...

  8. Ramanathan, Prof. Veerabhadran

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 2014 Honorary. Ramanathan, Prof. Veerabhadran. Date of birth: 24 November 1944. Address: Distinguished Victor C Alderson Professor, of Climate Sci., Scripps Institution of, Oceanography, UC at San Diego, 9500 Gilman Drive,MC 0221, La Jolla, CA 92093-0221, USA Contact:

  9. Mukhopadhyay, Prof. Dhrubajyoti

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1988 Section: Earth & Planetary Sciences. Mukhopadhyay, Prof. Dhrubajyoti Ph.D. (London), FNA, FNASc. Date of birth: 19 September 1938. Specialization: Structural Geology, Precambrian Geology Address: G-7, MIG Housing Colony, 25/3, Raja Manindra Road, Kolkata 700 037, ...

  10. Gopakumar, Prof. Rajesh

    Indian Academy of Sciences (India)

    Elected: 2009 Section: Physics. Gopakumar, Prof. Rajesh Ph.D. (Princeton), FNA, FNASc, FTWAS. Date of birth: 14 December 1967. Specialization: Theoretical Physics, Quantum Field Theory and String Theory Address: Director, International Centre for Theoretical Sciences, Shivakote, Hesaraghatta Post, Bengal;uru 560 ...

  11. Panda, Prof. Sudhakar

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 2017 Section: Physics. Panda, Prof. Sudhakar Ph.D. (IoP, Bhubaneswar), FNA, FNASc. Date of birth: 23 February 1959. Specialization: High Energy Physics, String Theory, Cosmology, Quantum Field Theory Address: Director, Institute of Physics, Sachivalaya Marg, Bhubaneswar 751 005, Orissa

  12. Cheetham, Prof. Antony Kevin

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 2001 Honorary. Cheetham, Prof. Antony Kevin FRS. Date of birth: 16 November 1946. Address: Dept. of Materials Science &, Metallurgy, University of Cambridge, 27, Charles Babbage Road, Cambridge CB3 0FS, uk. Contact: Office: (+44-1223) 74 6733. Fax: (+44-1223) 33 4567

  13. Pavlov, Prof. Ivan Petrovich

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1935 Honorary. Pavlov, Prof. Ivan Petrovich Nobel Laureate (Medicine) - 1904. Date of birth: 27 September 1849. Date of death: 27 February 1936. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

  14. Ratajczak, Prof. Henryk

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1992 Honorary. Ratajczak, Prof. Henryk. Date of birth: 30 September 1932. Address: Vice President, Faculty of Chemistry, University of Wroclaw, 14, Joliet-Curie Street, 50-383 Wroclaw, Poland Contact: Office: (+48-71) 375 73 18. Residence: (+48-71) 351 98 99. Fax: (+48-71) 328 ...

  15. Nicolaou, Prof. Kyriacos Costa

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 2007 Honorary. Nicolaou, Prof. Kyriacos Costa. Date of birth: 1946. Address: Department of Chemistry & BRC, Rice University, 6100, Main Street, MS 602, Houston, TX 77005, U.S.A.. Contact: Residence: (+1-713) 348 8860. Fax: (+1-713) 348 8865. Email: kcn@rice.edu. YouTube; Twitter; Facebook ...

  16. Hartl, Prof. Daniel L

    Indian Academy of Sciences (India)

    Hartl, Prof. Daniel L. Date of birth: 1 January 1943. Address: Higgins Professor of Biology, Dept. of Organismic & Evolutionary, Biology, The Biological Lab., Harvard University, 16 Divinity Ave, Cambridge, MA 02138, USA Contact: Office: (+1-617) 496 3917. Email: dhartl@oeb.harvard.edu. YouTube; Twitter; Facebook; Blog ...

  17. Prasad, Prof. Rajendra

    Indian Academy of Sciences (India)

    Elected: 2000 Section: General Biology. Prasad, Prof. Rajendra Ph.D. (Agra), FNASc, FNA. Date of birth: 14 October 1947. Specialization: Membrane Biology, Yeast Genetics & Molecular Biology and Medical Mycology Address: Director, Amity Institute of Biotechnology, Amity University, Amity Education Valley, Gurgaon 122 ...

  18. Haworth, Prof. Walter Norman

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1948 Honorary. Haworth, Prof. Walter Norman Nobel Laureate (Chemistry) - 1937. Date of birth: 19 March 1883. Date of death: 19 March 1950. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

  19. Rao, Prof. Maddali Nageswara

    Indian Academy of Sciences (India)

    Rao, Prof. Maddali Nageswara Dr. rer. nat. (Cologne). Date of birth: 11 July 1931. Specialization: Solar System Physics, Mars Fundamental Research, Earth & Planetary Sciences and Lunar & Meteorite Sample Studies Address: 16931, Tower Ridge, Friendswood, Texas 77546, USA Contact: Residence: (+1-281) 993 9191

  20. Rao, Prof. Valipe Ramgopal

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 2009 Section: Engineering & Technology. Rao, Prof. Valipe Ramgopal FNAE, FNASc, FNA, FIEEE. Date of birth: 16 August 1965. Specialization: Nanoelectronics and Nanotechnology Address: Director, Indian Institute of Technology, Hauz Khas, New Delhi 110 016, U.T.. Contact:

  1. Chakravarti, Prof. Aravinda

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 2008 Honorary. Chakravarti, Prof. Aravinda. Date of birth: 6 February 1954. Address: Director - CCDG, McKusick-Nathans Inst. of Genetic, Medicine, Johns Hopkins Univ., School of Medicine, 733 N.Broadway, Baltimore, MD 21205, USA Contact: Office: (+1-410) 502 7525. Fax: (+1-410) 502 7544

  2. Kumar, Prof. Har Darshan

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 1975 Section: Plant Sciences. Kumar, Prof. Har Darshan Ph.D. (London), FNA, FNASc. Date of birth: 25 February 1934. Specialization: Algology, Microbial Biotechnology, Genetics, Ecology and Environment Address: Mrigtrishna, B.32/32, H.K. 214, Saketnagar Colony, Naria, Varanasi 221 005, U.P.

  3. Dhar, Prof. Suman Kumar

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 2016 Section: General Biology. Dhar, Prof. Suman Kumar Ph.D. (JNU). Date of birth: 6 March 1968. Specialization: DNA Replication, Cell Cycle Control, Molecular Parasitology, Bacteriology Address: Special Centre for Molecular Medicine, Jawaharlal Nehru University, New Delhi 110 067, U.T.

  4. Dhar, Prof. D

    Indian Academy of Sciences (India)

    Home; Fellowship; Associateship. Associate Profile. Period: 1983–1986. Dhar, Prof. D. Date of birth: 30 October 1951. Specialization: Statistical Physics Address during Associateship: Theoretical Physics Group, Tata Inst. of Fundamental Research, Homi Bhabha Road, Mumbai 400 005. YouTube; Twitter; Facebook; Blog ...

  5. Tandon, Prof. Prakash Narain

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1983 Section: Medicine. Tandon, Prof. Prakash Narain M.B.B.S. (Lucknow), M.S., D.Sc. (h.c.), FRCS, FNA, FNASc, FTWAS, FAMS. Date of birth: 13 August 1928. Specialization: Neurosciences and Neurosurgery Address: No. 1, Jagriti Enclave, Vikas Marg Extension, Delhi 110 092, ...

  6. Vishveshwara, Prof. Saraswathi

    Indian Academy of Sciences (India)

    Vishveshwara, Prof. Saraswathi Ph.D. (CUNY), FNASc. Date of birth: 30 April 1946. Specialization: Computational Biology, Molecular Dynamics & Graph Theoretic Approaches to Biomolecular Structure & Function Address: NASI Senior Scientist, Molecular Biophysics Unit, Indian Institute of Science, Bengaluru 560 012, ...

  7. Bansal, Prof. Manju

    Indian Academy of Sciences (India)

    Bansal, Prof. Manju Ph.D. (IISc), FNASc, FNA. Date of birth: 1 December 1950. Specialization: Computational Structural Biology, Computational Genome Analysis and Biomolecular Modelling Address: INSA Senior Scientist, Molecular Biophysics Unit, Indian Institute of Science, Bengaluru 560 012, Karnataka Contact:

  8. Mondal, Prof. Naba Kumar

    Indian Academy of Sciences (India)

    Mondal, Prof. Naba Kumar Ph.D. (Bombay) D.Sc. (h.c.), FNA, FNASc, FTWAS. Date of birth: 11 March 1951. Specialization: Experimental Particle Physics, Accelerator-based Particle Physics and Neutrino Physics Address: Raja Ramanna Fellow, Saha Institute of Nuclear Physics, 1/AF, Bidhan Nagar, Kolkata 700 064, W.B.

  9. Chandrashekaran, Prof. Maroli Krishnayya

    Indian Academy of Sciences (India)

    Elected: 1983 Section: Animal Sciences. Chandrashekaran, Prof. Maroli Krishnayya Ph.D. (Madras), D.Sc. (Madurai), FNA, FNASc, FTWAS Council Service: 1992-97. Date of birth: 4 January 1937. Date of death: 2 July 2009. Specialization: Chronobiology and Animal Behaviour Last known address: Evolutionary and ...

  10. Engstrom, Prof. Arne Vilhelm

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1970 Honorary. Engstrom, Prof. Arne Vilhelm. Date of birth: 15 May 1920. Date of death: 19 July 1996. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year meeting of the Academy will be held from ...

  11. Bose, Prof. Satyendra Nath

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1973 Honorary. Bose, Prof. Satyendra Nath. Date of birth: 1 January 1894. Date of death: 4 February 1974. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year meeting of the Academy will be held ...

  12. Bhattacharya, Prof. Alok

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 2015 Section: General Biology. Bhattacharya, Prof. Alok Ph.D. (JNU), FNA. Date of birth: 2 February 1951. Specialization: Molecular Parasitology, Computational Genomics, Rare Genetic Disorders Address: School of Life Sciences, Jawaharlal Nehru University, New Delhi 110 067, ...

  13. Nocera, Prof. Daniel G

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 2013 Honorary. Nocera, Prof. Daniel G. Date of birth: 1957. Address: Dept. of Chemistry & Chem. Biol., Harvard University, 12, Oxford Street, Cambridge, MA 02138, USA Contact: Office: (+1-617) 495 8904. Email: dnocera@fas.harvard.edu. http://chemistry.harvard.edu/people/daniel-g-nocera.

  14. Shaila, Prof. Melkote Subbarao

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 1993 Section: General Biology. Shaila, Prof. Melkote Subbarao Ph.D. (IISc). Date of birth: 10 October 1945. Specialization: Molecular Virology and Viral Immunology Address: Professor Emeritus, Department of Microbiology and Cell Biology, Indian Institute of Science, Bengaluru 560 012, Karnataka

  15. Pai, Prof. Mangalore Anantha

    Indian Academy of Sciences (India)

    Elected: 1979 Section: Engineering & Technology. Pai, Prof. Mangalore Anantha Ph.D. (UC, Berkeley), FNA, FNAE, FIEEE. Date of birth: 5 October 1931. Specialization: Smart Grid, Power Systems, Stability, Control and Computation Address: Emeritus Professor, Department of Electrical & Computer Engineering, University ...

  16. Jagirdar, Prof. Balaji Rao

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 2013 Section: Chemistry. Jagirdar, Prof. Balaji Rao Ph.D. (Kansas State). Date of birth: 9 September 1965. Specialization: Organometallic Chemistry, Materials Chemistry, Catalysis Address: Department of Inorganic & Physical Chemistry, Indian Institute of Science, Bengaluru 560 012, Karnataka

  17. Prof. Parag P. Sadhale

    Indian Academy of Sciences (India)

    user

    2009-07-01

    Jul 1, 2009 ... Manimala Sen. Swati Deshpande. Pallavi Kakde. Ritu Gupta. Bhavna P. Bhavin Shah. Harigopala B. Kannan. Anandkumar. Prof. Parag P. Sadhale. Dept. of Microbiology and Cell Biology. July 2009. Financial support. DBT,. Piramal Life Sciences Mumbai. Indian Institute of Science. Bangalore- 560012.

  18. Vijayraghavan, Prof. Usha

    Indian Academy of Sciences (India)

    Vijayraghavan, Prof. Usha Ph.D. (Caltech), FNA. Date of birth: 25 August 1961. Specialization: Plant Developmental Genetics, Microbial Genetics and Gene Regulation Address: Professor, Microbiology & Cell Biology Department, Indian Institute of Science, Bengaluru 560 012, Karnataka Contact: Office: (080) 2360 0168

  19. Chaturvedi, Prof. Umesh Chandra

    Indian Academy of Sciences (India)

    Chaturvedi, Prof. Umesh Chandra M.D. (Lucknow), FRC Path. (London), FAMS, FNA, FNASc, FAAM(USA). Date of birth: 2 March 1939. Specialization: Medical Microbiology, Virology and Immunology Address: 201, Annapurna Apartments, No. 1, Bishop Rocky Street, Faizabad Road, Lucknow 226 007, U.P.. Contact:

  20. Das, Prof. Saumitra

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 2009 Section: General Biology. Das, Prof. Saumitra Ph.D. (Calcutta), FNASc, FNA. Date of birth: 20 January 1962. Specialization: Molecular Virology, Molecular Biology and Cell Biology Address: Microbiology and Cell Biology Department, Indian Institute of Science, Bengaluru 560 012, Karnataka

  1. Bhattacharyya, Prof. Prabhat Kumar

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1976 Section: Chemistry. Bhattacharyya, Prof. Prabhat Kumar Ph.D. (Illinois), FNA. Date of birth: 22 October 1921. Date of death: 16 April 1996. Specialization: Bio-organic Chemistry and Chemical Microbiology Last known address: 177, Jodhpur Park, Flat - 1S, Calcutta 700 068.

  2. Bhattacharya, Prof. Sudha

    Indian Academy of Sciences (India)

    Elected: 2001 Section: General Biology. Bhattacharya, Prof. Sudha Ph.D. (IARI, New Delhi), FNASc, FNA Council Service: 2016. Date of birth: 7 March 1952. Specialization: Molecular Biology, Molecular Parasitology and Genomics Address: Professor, School of Environmental Sciences, Jawaharlal Nehru University, New ...

  3. Surolia, Prof. Namita

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 2002 Section: Medicine. Surolia, Prof. Namita Ph.D. (Allahabad), FNASc. Date of birth: 2 April 1953. Specialization: Molecular Parasitology, Biochemistry and Molecular Biology Address: Molecular Biology & Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, ...

  4. The development status and protection of traditional qiang ethnic minority villages

    Science.gov (United States)

    Long, Yanping; He, Yunxiao; Yu, Chunhua; Chen, Mengxin

    2018-03-01

    This study is to focus on the protection of development countermeasures on the development status of Yinling village,and to provide beneficial suggestions for the development of the village. It is approached by analyzing the traditional village deeply from the situation of Yinling village, development status and protection countermeasures,taking the traditional Qiang Ethnic Minority village of Yinling village in Pinwu county, Sichuan province as an example,which is under the background that the protection and development of traditional ethnic villages have became the focus of attention,because traditional ethnic villages are living villages of traditional Chinese culture, retaining old and historic material remains.

  5. Varadhan, Prof. Srinivasa S R

    Indian Academy of Sciences (India)

    Varadhan, Prof. Srinivasa S R . Date of birth: 2 January 1940. Address: Department of Mathematics, Courant Institute, New York University, 251, Mercer Street, New York, NY 10012, U.S.A.. Contact: Office: (+1-212) 982 9883

  6. Study on Strata Behavior Regularity of 1301 Face in Thick Bedrock of Wei - qiang Coal Mine

    Science.gov (United States)

    Gu, Shuancheng; Yao, Boyu

    2017-09-01

    In order to ensure the safe and efficient production of the thick bedrock face, the rule of the strata behavior of the thick bedrock face is discussed through the observation of the strata pressure of the 1301 first mining face in Wei qiang coal mine. The initial face is to press the average distance of 50.75m, the periodic weighting is to press the average distance of 12.1m; during the normal mining period, although the upper roof can not be broken at the same time, but the pressure step is basically the same; the working face for the first weighting and periodical weighting is more obvious to the change of pressure step change, when the pressure of the working face is coming, the stent force increased significantly, but there are still part of the stent work resistance exceeds the rated working resistance, low stability, still need to strengthen management.

  7. VijayRaghavan, Prof. Krishnaswamy

    Indian Academy of Sciences (India)

    VijayRaghavan, Prof. Krishnaswamy Ph.D. (Mumbai), FNA, FNASc, FRS, FTWAS, Foreign Assoc. (US Natl. Acad. Sci.) Council Service: 2007-2009. Date of birth: 3 February 1954. Specialization: Developmental Biology, Genetics and Neurogenetics Address: Secretary, Department of Biotechnology, Block 2, CGO Complex, ...

  8. Krishna Murty, Prof. Achyutuni Venkata

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 1993 Section: Engineering & Technology. Krishna Murty, Prof. Achyutuni Venkata Ph.D. (IISc). Date of birth: 10 October 1938. Specialization: Aerospace Engineering, Structural Mechanics, Composites and Smart Structures Address: No. 8, 5th Main, II Cross, NTI Layout, RMV II Stage, Nagashettyhalli, ...

  9. Valiathan, Prof. Marthanda Varma Sankaran

    Indian Academy of Sciences (India)

    Valiathan, Prof. Marthanda Varma Sankaran Ch.M. (Liverpool), FRCS (England, Edinburgh & Canada), FRCP (London), D.Sc. (h.c.), FNA, FNASc, FNAE, FAMS, FTWAS Council Service: 1980-91; Vice-President: 1986-91. Date of birth: 24 May 1934. Specialization: Cardiac Surgery, Cardiovascular Materials and Ayurveda

  10. Mohan Ram, Prof. Holenarasipur Yoganarasimham

    Indian Academy of Sciences (India)

    Mohan Ram, Prof. Holenarasipur Yoganarasimham Ph.D. (Delhi), FNA, FNASc, FNAAS Council Service: 1983-88; Vice-President: 1986-88. Date of birth: 24 September 1930. Specialization: Plant Growth & Development and Economic Botany Address: No. 174, SFS DDA Flats, Mukherjee Nagar, Delhi 110 009, U.T.

  11. Dirac, Prof. Paul Adrien Maurice

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1935 Honorary. Dirac, Prof. Paul Adrien Maurice Nobel Laureate (Physics) - 1933. Date of birth: 8 August 1902. Date of death: 20 October 1984. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

  12. Guha-Mukherjee, Prof. Sipra

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 1988 Section: Plant Sciences. Guha-Mukherjee, Prof. Sipra Ph.D. (Delhi), FNASc. Date of birth: 30 July 1938. Date of death: 15 September 2007. Specialization: Plant Molecular Biology, Plant Tissue Culture and Genetic Engineering Last known address: Garden Estate, M A 1/6-3C, Gurgaon 122 002.

  13. Broglie, Prof. Louis Victor de

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1951 Honorary. Broglie, Prof. Louis Victor de. Nobel Laureate (Physics) - 1929. Date of birth: 15 August 1892. Date of death: 19 March 1987. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

  14. Rees, Prof. Lord Martin (John)

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1991 Honorary. Rees, Prof. Lord Martin (John) FRS. Date of birth: 23 June 1942. Address: Emeritus professor of Cosmology & Astrophysics, Institute of Astronomy, University of Cambridge, Madingley Road, Cambridge CB3 0HA, U.K.. Contact: Office: (+44-1223) 33 7548

  15. Chandola-Saklani, Prof. Asha

    Indian Academy of Sciences (India)

    Home; Fellowship. Fellow Profile. Elected: 1992 Section: Animal Sciences. Chandola-Saklani, Prof. Asha Ph.D. (Banaras). Date of birth: 3 February 1947. Specialization: Ornithology, Conservation Biology and Endocrinology Address: Apeejay Svran Institute of Biosciences and Clinical Research, Plot 26, Sector 32, Gurgaon ...

  16. Prof. Bookinkere Channakeshavaiah Subba Rao

    Indian Academy of Sciences (India)

    Annual Meetings · Mid Year Meetings · Discussion Meetings · Public Lectures · Lecture Workshops · Refresher Courses · Symposia · Live Streaming. Home; Fellowship. Fellow Profile. Elected: 1975 Section: Chemistry. Subba Rao, Prof. Bookinkere Channakeshavaiah Ph.D. (Purdue). Date of birth: 8 December 1923

  17. Patel, Prof. Chandra Kumar Naranbhai

    Indian Academy of Sciences (India)

    Elected: 1995 Honorary. Patel, Prof. Chandra Kumar Naranbhai. Date of birth: 2 July 1938. Address: President & CEO, Pranalytica Inc., 1101, Colorado Avenue, Santa Monica, CA 90401, U.S.A.. Contact: Office: (+1-310) 458 0808. Residence: (+1-310) 471 6505. Fax: (+1-310) 458 0171. Email: patel@pranalytica.com.

  18. Patel, Prof. Chandra Kumar Naranbhai

    Indian Academy of Sciences (India)

    Patel, Prof. Chandra Kumar Naranbhai. Date of birth: 2 July 1938. Address: President & CEO, Pranalytica Inc., 1101, Colorado Avenue, Santa Monica, CA 90401, U.S.A.. Contact: Office: (+1-310) 458 0808. Residence: (+1-310) 471 6505. Fax: (+1-310) 458 0171. Email: patel@pranalytica.com. YouTube · Twitter · Facebook ...

  19. Geim, Prof. Sir Andre Konstantin

    Indian Academy of Sciences (India)

    Fellow Profile. Elected: 2015 Honorary. Geim, Prof. Sir Andre Konstantin FRS. Date of birth: 21 October 1958. Address: Royal Society Research Professor, University of Manchester, Oxford Road, Manchester M13 9PL, UK Contact: Office: (+44-161) 275 4120. Email: geim@manchester.ac.uk. YouTube; Twitter; Facebook ...

  20. Thomas, Prof. Sir John Meurig

    Indian Academy of Sciences (India)

    Thomas, Prof. Sir John Meurig FRS. Date of birth: 15 December 1932. Address: Department of Materials Science and, Metallurgy, New Museums Site, 27, Babbage ... Theory Of Evolution. Posted on 23 January 2018. Joint Statement by the Three Science Academies of India on the teaching of the theory of evolution more.

  1. King, Prof. Sir David Anthony

    Indian Academy of Sciences (India)

    Elected: 1998 Honorary. King, Prof. Sir David Anthony Sc.D., FRS. Date of birth: 12 August 1939. Address: Chief Scientific Adivser & Head, Office of Science and Innovation, London SW1H 0ET, U.K.. Contact: Office: (+44-020) 7215 3821. Fax: (+44-020) 7215 0314. Email: mpst.king@dti.gsi.gov.uk, dak10@cus.cam.ac.uk.

  2. [Treatment of otorhinolaryngologic diseases of deficient heat type with Professor XIE Qiang's Tihu Guanding needling method].

    Science.gov (United States)

    Chen, Dan; Xie, Qiange; Huang, Bing-Lin

    2014-01-01

    Professor XIE Qiang's Tihu Guanding needling method, a kind of acupuncture method which takes acupoints of the Conception Vessel as the primary and acupoints of the Governor Vessel as the secondary. Acupoints Lianquan (CV 23), Tiantu (CV 22), Qihai (CV 6), Zhongwan (CV 12), Baihui (GV 20) and Dazhui (GV 14) are adopted as the basic ones. Other points can be added according to various symptoms, for instance, Yingxiang (LI 20) and Yintang (GV 29) for rhinopathy, Tinggong (SI 19) and Yifeng (TE 17) for otopathy, Yan'an (Professor XIE's experience) and Shanglianquan (EX-HN 21) for pharyngopathy and Kaiyin 1 (Professor XIE's experience) and Kaiyin 2 (Professor XIE's experience) for laryngopathy. During the needle retention, rotation manipulation should be done every 5 min at Lianquan (CV 23). And the patient should be told to put the tip of one's tongue at the the palate as well as to do deep breathing to communicate the Conception Vessel and the Governor Vessel. Moxibustion is adopted at Yongquan (KI 1) to induce the up floating fire to mingmen (where the primary yang is stored). The therapeutic effect on treatment of persistent otorhinolaryngologic diseases with the above mentioned method is approve to be good.

  3. - In vivo monitoring of 5-FU

    OpenAIRE

    Lucas, Susanne

    2010-01-01

    The aim of the present study was to establish the in vivo-monitoring of the enrichment of 5-FU liposomes in liver and liver metastases by MRI methods. Relative signal intensities of liver and tumor tissue were determined. After sacrifying animals concentrations of 5-FU and it´s active intracellular metabolite M3 were measured by HPLC techniques. We used CC531 adenocarcinoma in the liver of WAG/Rij rats as a standardized liver tumor model in our investigatio...

  4. FuSuMaTech workshop

    CERN Multimedia

    Olofsson, Simon

    2018-01-01

    The goal of the FuSuMaTecH IP workshop, organised at CERN Ideaquare 19-20 April, was to educate superconductivity and magnet experts about intellectual property. About 30 participants from multiple institutes and companies worked together in this two day interactive program which was facilitated by CERN Knowledge Transfer. Great progress was made in shaping the FuSuMaTech industrial demonstrator projects as well as the R&D&I subjects.

  5. 5-FU Metabolism in Cancer and Orally-Administrable 5-FU Drugs

    Directory of Open Access Journals (Sweden)

    Iwao Sasaki

    2010-09-01

    Full Text Available 5-Fluorouracil (5-FU is a key anticancer drug that for its broad antitumor activity, as well as for its synergism with other anticancer drugs, has been used to treat various types of malignancies. In chemotherapeutic regimens, 5-FU has been combined with oxaliplatin, irinotecan and other drugs as a continuous intravenous infusion. Recent clinical chemotherapy studies have shown that several of the regimens with oral 5-FU drugs are not inferior compared to those involving continuous 5-FU infusion chemotherapy, and it is probable that in some regimens continuous 5-FU infusion can be replaced by oral 5-FU drugs. Historically, both the pharmaceutical industry and academia in Japan have been involved in the development of oral 5-FU drugs, and this review will focus on the current knowledge of 5-FU anabolism and catabolism, and the available information about the various orally-administrable 5-FU drugs, including UFT, S-1 and capecitabine. Clinical studies comparing the efficacy and adverse events of S-1 and capecitabine have been reported, and the accumulated results should be utilized to optimize the treatment of cancer patients. On the other hand, it is essential to elucidate the pharmacokinetic mechanism of each of the newly-developed drugs, to correctly select the drugs for each patient in the clinical setting, and to further develop optimized drug derivatives.

  6. Prof. Xiao Shaoqin's Experience in Acupuncture Treatment

    Institute of Scientific and Technical Information of China (English)

    许国杰

    2001-01-01

    @@ Having been engaged in TCM for 50 years, Prof. Xiao Shaoqin has got rich experience in acupuncture. The author has pursued advanced studies for 3 years under his guidance, and has learned a lot from him. The following is a report of Prof. Xiao Shaoqin's experience for treating 3 typical eases.

  7. Prof. Oscar Vogt (1927 - 2014)

    International Nuclear Information System (INIS)

    Wachter, Peter

    2014-01-01

    On 21st. Jan. 2014 Oscar Vogt left us. Born in 1927, he lived a long and fulfilling life. One of us (PW) first met Oscar Vogt and his wife Ditta in 1962, when we both investigated in the Laboratorium für Festkörperphysik of ETH Zürich (Swiss Federal Institute of Technology) the magnetic properties of rare-earth compounds. Oscar was a son of the owner of Vogt and Co. (VoCo), a wire-fabrication company, which could also make exotic wires like tungsten. He received his PhD at ETH Zürich with Prof G. Busch, who When his father died in the 1970s, Oscar faced a choice – physics or the family business. He managed both! Every Monday he spent in the Institute, and with his competent technical assistant Kurt Mattenberger, grew large and welldefined single crystals of rare-earth compounds and investigated their magnetic properties. The production of crystals was especially challenging as these compounds melt only near 2000 °C, and special tungsten crucibles had to be maintained at g , mentioned that he was the only graduate student not asking for payment. He enjoyed interesting hobbies and was much involved in cultural activities. He engaged himself with great enthusiasm, initially in the research of rareearth compounds, and then later in the actinides.We had a long-lasting and fruitful friendship

  8. van den Heuvel, Prof. Edward P J

    Indian Academy of Sciences (India)

    van den Heuvel, Prof. Edward P J . Date of birth: 2 November 1940. Address: Professor of Astrophysics, Astronomical Inst. Anton Pannekoek, Postbus 94249, 1090 GE Amsterdam, The Netherlands Contact: Office: (+31-20) 525 ...

  9. Teaching Tu Fu on the Night Shift.

    Science.gov (United States)

    Brady, Philip

    1995-01-01

    Describes a teacher's unsuccessful attempt to introduce the poetry of Tu Fu, a wayward bureaucrat of the T'ang dynasty, to a class of part-time students. Uses his students' resistance to this poetry as an occasion to discuss the importance of personal responses to poetry, as opposed to "correct" academic responses. (TB)

  10. TPÜ muuseumis avati prof Raimo Pullati isikunäitus

    Index Scriptorium Estoniae

    2002-01-01

    17. aprillil avati TPÜ muuseumis prof Raimo Pullati isikunäitus. Näitusel on eksponeeritud ka kaheksa teost, mille eest autasustati prof Pullatit 2001. aastal Balti Assamblee teaduspreemigaga : [täistekst

  11. Sopory, Prof. Sudhir Kumar - IAS Fellow

    Indian Academy of Sciences (India)

    Elected: 1992 Section: Plant Sciences. Sopory, Prof. Sudhir Kumar Ph.D. (Delhi), FNA, FNASc, FNAAS, FTWAS Council Service: 2001-2006. Date of birth: 7 January 1948. Specialization: Molecular Plant Physiology and Plant Tissue Culture & Transformation Address: 584, Sector 14, Faridabad 121 007, Haryana Contact:

  12. EDITORIAL NEWS Thank you, Prof Mollentze

    African Journals Online (AJOL)

    ... send through a heartfelt thank you when a publication has been finalised. Prof Mollentze, we at Medpharm wish you every success on the road ahead, wherever your research interests take you. Thank you for your invaluable service to the journal, the readers, and the Medpharm team. Ina du Toit. Chief Executive Officer.

  13. Prof. DR. F. C. Eloff - An appreciation

    Directory of Open Access Journals (Sweden)

    G de Graaff

    1984-12-01

    Full Text Available I have been requested to write an appreciation of the man to whom these proceedings of a symposium on the Kalahari Ecosystem are dedicated @ Prof. Dr. F. C. Eloff, or Fritz as he is popularly referred to. I undertook the task with some trepidation and the only claim to the honour to write this article may be the fact that I have known Professor Eloff since 1949 when I was a green-shanked first year veterinary student at the University of Pretoria where he lectured in zoology to the new students.

  14. Online Canton Fairs Ready for Convenient Trade--An Interview with Ding Qiang, General Manager of MOFCOM China International Electronic Commerce Center

    Institute of Scientific and Technical Information of China (English)

    Li Yinghong; Sun Yongjian

    2006-01-01

    @@ In 2006, the Canton Fairs will greet the 99th and 100th respectively in spring and fall. To meet the need of the development of the convenient trade, the Canton Fairs website, the platform of the online Canton Fairs run by MOFCOM China International Electronic Commerce Center is ready to take several effective measures to offer more convenient services. On March 24, China's Foreign Trade took the occasion to interview with Mr. Ding Qiang, General Manager of MOFCOM China International Electronic Commerce Center.

  15. Zuordnungsprozesse bei Fußballzuschauern - Zur Salienz teambezogener Kategorien

    OpenAIRE

    Roschmann, Regina

    2013-01-01

    Sport im Allgemeinen und Fußball im Besonderen erfreuen sich nicht nur unter aktiven Sportlern, sondern auch unter Zuschauern aktuell hoher Beliebtheit. Angesichts teils enormer Einschaltquoten scheint es wahrscheinlich, dass Fußballspiele nicht nur von Fans der beteiligten Mannschaften verfolgt werden. Dies kann sowohl gänzlich neutrale Zuschauer als auch Anhänger anderer Teams betreffen. Während Fans allerdings durch die Literatur bereits ausführliche Aufmerksamkeit erfahren haben und durch...

  16. Health benefits of Kung Fu: a systematic review.

    Science.gov (United States)

    Tsang, Tracey Wai Man; Kohn, Michael; Chow, Chin Moi; Singh, Maria Fiatarone

    2008-10-01

    The Chinese martial arts (Kung Fu) have existed for centuries and are generally accepted as being beneficial for health without much empirical data. The aim of this systematic review was to assess the health effects of "hard" Kung Fu styles by performing electronic and manual searches of the literature. The aspects of health and the Kung Fu style examined varied between most studies; in some cases, the martial art group consisted of practitioners of other martial art styles also. Of 2103 references identified, only nine papers were eligible and reviewed. All were observational studies, observing a range of health aspects possibly related to Kung Fu training or performance. Our findings suggest that there is no evidence that Kung Fu practice is associated with the prevention or treatment of any health condition. However, as a moderate- to high-intensity form of aerobic exercise, it may confer benefits similar to those attributed to other aerobic training modalities. However, this hypothesis remains to be tested in clinical trials. Physiological benefits (e.g., aerobic capacity and bone density) may be associated with long-term Kung Fu practice. Future research in this area should adopt experimental designs, clearly identifying eligibility criteria, testing and training protocols, and include health-related outcomes and documentation of adverse events, to advance knowledge in this field.

  17. Cellular response to 5-fluorouracil (5-FU in 5-FU-resistant colon cancer cell lines during treatment and recovery

    Directory of Open Access Journals (Sweden)

    Kravik Katherine L

    2006-05-01

    Full Text Available Abstract Background Treatment of cells with the anti-cancer drug 5-fluorouracil (5-FU causes DNA damage, which in turn affects cell proliferation and survival. Two stable wild-type TP53 5-FU-resistant cell lines, ContinB and ContinD, generated from the HCT116 colon cancer cell line, demonstrate moderate and strong resistance to 5-FU, respectively, markedly-reduced levels of 5-FU-induced apoptosis, and alterations in expression levels of a number of key cell cycle- and apoptosis-regulatory genes as a result of resistance development. The aim of the present study was to determine potential differential responses to 8 and 24-hour 5-FU treatment in these resistant cell lines. We assessed levels of 5-FU uptake into DNA, cell cycle effects and apoptosis induction throughout treatment and recovery periods for each cell line, and alterations in expression levels of DNA damage response-, cell cycle- and apoptosis-regulatory genes in response to short-term drug exposure. Results 5-FU treatment for 24 hours resulted in S phase arrests, p53 accumulation, up-regulation of p53-target genes on DNA damage response (ATF3, GADD34, GADD45A, PCNA, cell cycle-regulatory (CDKN1A, and apoptosis-regulatory pathways (FAS, and apoptosis induction in the parental and resistant cell lines. Levels of 5-FU incorporation into DNA were similar for the cell lines. The pattern of cell cycle progression during recovery demonstrated consistently that the 5-FU-resistant cell lines had the smallest S phase fractions and the largest G2(/M fractions. The strongly 5-FU-resistant ContinD cell line had the smallest S phase arrests, the lowest CDKN1A levels, and the lowest levels of 5-FU-induced apoptosis throughout the treatment and recovery periods, and the fastest recovery of exponential growth (10 days compared to the other two cell lines. The moderately 5-FU-resistant ContinB cell line had comparatively lower apoptotic levels than the parental cells during treatment and recovery

  18. Kritik Atas Modernitas Dalam Novel Bilangan Fu Karya Ayu Utami

    Directory of Open Access Journals (Sweden)

    Bramantio Bramantio

    2015-06-01

    Full Text Available Artikel ini bertujuan untuk mengungkap kritik atas modernitas dalam novel Bilangan Fu karya Ayu Utami. Dengan memanfaatkan naratologi Tzvetan Todorov, dapat dipahami aspek verbal Bilangan Fu, yaitu sudut pandang, pencerita, dan tuturannya. Berdasarkan penceritaannya, novel ini merupakan novel polifonik, karnivalistik, sekaligus metafiksi. Berdasarkan kontennya, novel ini menghadirkan sejumlah kritik atas modernitas, khususnya berkaitan dengan semangat modernitas yang cenderung melihat segala sesuatu secara monodimensional, hanya ada satu kebenaran, dan liyan diabaikan. Bilangan Fu merupakan novel yang merefleksikan zamannya. Novel ini berhasil menyegarkan cara pandang masyarakat Indonesia, atau setidaknya menghadirkan sesuatu untuk dipikirkan dan dipertimbangkan kembali, berkaitan dengan diri, lingkungan, dan semesta raya. Novel ini mengembalikan manusia ke hakikatnya, yaitu kemanusiaan. Abstract: This article aims to reveal criticism on modernity in Ayu Utami’s novel Bilangan Fu. Tzvetan Todorov’s theory of narrative provided a framework to understand the novel’s verbal aspects, which are point of view, narrator, dan its voice. Based on its narrative, this novel is polyphonic, carnivalistic, and metafictional. Based on its content, it presents criticism on modernity, particularly on spirit of modernity that tends to see everything in monodimensional; there is only one truth, and the other is ignored. Bilangan Fu is a novel that reflects its time. It successfully refreshes the perspective of Indonesian society, or at least brings something to think about, related to the self, environment, and the universe. In the end, it brings back human being to their core, their humanity. Key Words: novel; point of view; narrator; criticism; modernity

  19. Fučík spectra for vector equations

    Directory of Open Access Journals (Sweden)

    Christian Fabry

    2000-01-01

    Full Text Available Let $L:\\hbox{dom} L\\subset L^2(\\Omega;R^N\\rightarrow L^2(\\Omega;R^N$ be a linear operator, $\\Omega$ being open and bounded in $R^M$. The aim of this paper is to study the Fu\\v c\\'\\i k spectrum for vector problems of the form $Lu=\\alpha Au^+ -\\beta Au^-$, where $A$ is an $N\\times N$ matrix, $\\alpha, \\beta$ are real numbers, $u^+$ a vector defined componentwise by $(u^+_i=\\max\\{u_i,0\\}$, $u^-$ being defined similarly. With $\\lambda^*$ an eigenvalue for the problem $Lu=\\lambda Au$, we describe (locally curves in the Fučík spectrum passing through the point $(\\lambda^*,\\lambda^*$, distinguishing different cases illustrated by examples, for which Fučík curves have been computed numerically.

  20. NSA Profs. Barma and Piombo Publish Jointly in International Peacekeeping

    OpenAIRE

    2016-01-01

    National Security Affairs (NSA) News Two NSA faculty, Profs. Naazneen Barma and Jessica Piombo have authored an article with Naomi Levy of Santa Clara University, titled “Disentangling Aid Dynamics in Statebuilding and Peacebuildin: A Causal Framework.”

  1. Prof. John Wood, Chief Executive Designate, Dr Gordon Walker, Directorate, Chief Executive, Prof. Ken J. Peach, Head of the Particle Physics Department, CLRC Rutherford Appleton Laboratory, United Kingdom

    CERN Multimedia

    Patrice Loïez

    2001-01-01

    L. to. r.: Dr. Ian Wilson, CLIC Deputy Study Leader, Prof. Ken J. Peach, Head of the Particle Physics Department, Prof. John Wood, Chief Executive Designate, Dr. Gordon Walker, Directorate, Chief Executive

  2. Infection witb'l\\:fued GastrointestinafNematOde Parasites ',' .:

    African Journals Online (AJOL)

    Resistance of Three Strains 'of Sinall EasL~friCan 'Goats to Artificial. Infection witb'l\\:fued ... TWC and mortality among the SEA gOat strains, Gogo goats had significantly lower FEC (606 ejJg). ]WC (529) and .... Chi-square test. This involved ...

  3. X-shooter spectroscopy of FU Tauri A

    Science.gov (United States)

    Stelzer, B.; Alcalá, J. M.; Scholz, A.; Natta, A.; Randich, S.; Covino, E.

    2013-03-01

    We have analyzed a broad-band optical and near-infrared spectrum of FU Tau A, which is a presumed young brown dwarf in the Taurus star forming region that has intrigued both theorists and observers by its overluminosity in the Hertzsprung-Russell (HR) diagram with respect to standard pre-main sequence evolutionary models. FU Tau A is brighter than any other Taurus member of the same or similar spectral type, and various phenomena (accretion, activity, binarity) have been put forth as possible explanations. The new data, obtained with the X-shooter spectrograph at the Very Large Telescope, include an unprecedented wealth of information on stellar parameters and simultaneously observed accretion and outflow indicators for FU Tau A. We present the first measurements of gravity (log g = 3.5 ± 0.5), radial velocity (RV = 22.5 ± 2.9 km s-1), rotational velocity (vsini = 20 ± 5 km s-1), and lithium equivalent width (EWLi = 430 ± 20 mÅ) for FU Tau A. From the rotational velocity and the published period we infer a disk inclination of i ≳ 50°. The lithium content is much lower than theoretically expected for such a young very low-mass object, adding another puzzling feature to this object's properties. We determine the mass accretion rate of FU Tau A from comparison of the luminosities of 20 emission lines to empirical calibrations from the literature and find a mean of log Ṁacc [M⊙/yr] = -9.9 with standard deviation σ = 0.2. The accretion rate determined independently from modeling of the excess emission in the Balmer and Paschen continua is consistent with this value. The corresponding accretion luminosity is too low to make a significant contribution to the bolometric luminosity. Strong magnetic activity affecting the stellar parameters or binarity of FU Tau A, both combined with extreme youth, may be responsible for its position in the HR diagram. The existence of an outflow in FU Tau A is demonstrated through the first detection of forbidden emission lines

  4. First Results from the AKARI FU-HYU Mission Program

    Science.gov (United States)

    Pearson, C.; Serjeant, S.; Takagi, T.; Jeong, W.-S.; Negrello, M.; Matsuhara, H.; Wada, T.; Oyabu, S.; Lee, H. M.; Im, M.

    2009-12-01

    The AKARI FU-HYU mission program has carried out mid-infrared imaging of several well studied Spitzer fields. This imaging fills in the wavelength coverage lacking from the Spitzer surveys and gives an extremely high scientific return for minimal input for AKARI. We select fields already rich in multi-wavelength data from radio to X-ray wavelengths and present the results from our initial analysis in the GOODS-N field. We utilize the comprehansive multiwavelength coverage in the GOODS-N field to produce a multiwavelength catalogue from infrared to ultraviolet wavelengths including photometric redshifts. Using the FU-HYU catalogue we present colour-colour diagrams that map the passage of PAH features through our observation bands. These colour-colours diagrams are used as tools to extract anomalous colour populations, in particular a population of Silicate Break galaxies from the GOODS-N field.

  5. Ring-shaped nebulae around FU Orionis stars

    International Nuclear Information System (INIS)

    Goodrich, R.W.

    1987-01-01

    Observational data on the morphology and spectra of the nebulae surrounding V1057 Cyg, V1515 Cyg, and V1735 Cyg stars are presented and studied. The data reveal that V1735 Cyg is more highly reddened than the nebula and the spectra of all three nebulae are from reflection. A simple model for the dust shell is proposed and it is argued that the shells may indicate a relatively advanced evolutionary state for the FU Orionis star. The relation between the shells and the evolution of the stars is examined. The models of Herbig (1977), Mould et al. (1978), Larson (1980), and Hartmann and Kenyon (1985), which are utilized to analyze the FU Orionis outburst phenomenon, are tested. 23 references

  6. Visuospatial attention and motor skills in kung fu athletes.

    Science.gov (United States)

    Muiños, Mónica; Ballesteros, Soledad

    2013-01-01

    The present study compared the performance of a group of sixteen kung fu athletes with that of a control group of fourteen nonathletes on a speeded visuospatial task and a hand-tapping motor task. In the visuospatial task the results showed that athletes were faster than the control participants when stimuli were presented at the periphery of the visual field at a middle and high presentation speed with short interstimulus intervals. Athletes were also significantly faster than nonathlete participants when performing motor actions such as hand-tapping with their dominant hand but groups did not differ with the nondominant hand. These results support the view that athletes perform some speeded visuospatial and motor tasks faster than nonathletes under certain conditions. The findings suggest that, after several years of practice, kung fu athletes develop certain skills that allow them to perform motor speed maneuvers under time pressure conditions.

  7. En procesorienteret miljøvurdering af F&U

    DEFF Research Database (Denmark)

    Lyhne, Ivar

    Miljøperformance af fremtidens energiteknologier defineres i høj grad i de tidlige F&U aktiviteter. Energinet.dk har i flere år miljøvurderet ForskEL-programmet og i dette projekt forbedres systemets nytte ved at muliggøre øgede krav til programmets samlede performance og følge op på projekternes...

  8. THE MID-INFRARED EVOLUTION OF THE FU ORIONIS DISK

    Energy Technology Data Exchange (ETDEWEB)

    Green, Joel D.; Jones, Olivia C.; Poteet, Charles A.; Sargent, Benjamin A. [Space Telescope Science Institute, Baltimore, MD 21218 (United States); Keller, Luke D. [Department of Physics and Astronomy, Ithaca College, Ithaca, NY (United States); Yang, Yao-Lun; Evans II, Neal J. [Department of Astronomy, The University of Texas at Austin, Austin, TX 78712 (United States); Fischer, William J. [Goddard Space Flight Center, Greenbelt, MD 20771 (United States); Rebull, Luisa M. [IPAC, Pasadena, CA 91125 (United States)

    2016-11-20

    We present new SOFIA-FORCAST observations obtained in 2016 February of the archetypal outbursting low-mass young stellar object FU Orionis, and we compare the continuum, solid-state, and gas properties with mid-infrared data obtained at the same wavelengths in 2004 with Spitzer -IRS. In this study, we conduct the first mid-infrared spectroscopic comparison of an FUor over a long time period. Over a 12-year period, UBVR monitoring indicates that FU Orionis has continued its steady decrease in overall brightness by ∼14%. We find that this decrease in luminosity occurs only at wavelengths ≲20 μ m. In particular, the continuum shortward of the silicate emission complex at 10 μ m exhibits a ∼12% (∼3 σ ) drop in flux density but no apparent change in slope; both the Spitzer and SOFIA spectra are consistent with a 7200 K blackbody. Additionally, the detection of water absorption is consistent with the Spitzer spectrum. The silicate emission feature at 10 μ m continues to be consistent with unprocessed grains, unchanged over 12 years. We conclude that either the accretion rate in FU Orionis has decreased by ∼12–14% over this time baseline or the inner disk has cooled, but the accretion disk remains in a superheated state outside the innermost region.

  9. Chemoradiotherapy using platinum analogs/5-FU for advanced esophageal cancer

    International Nuclear Information System (INIS)

    Shibata, Shigeru; Kawasaki, Hitoshi; Nakai, Makoto; Morohashi, Hajime; Matsuya, Hideki; Yamada, Kyougo; Morita, Takayuki; Sasaki, Mutsuo

    2002-01-01

    We evaluated the efficacy of concurrent chemoradiotherapy (CRT) using cisplatin/nedaplatin and 5-fluorouracil (5-FU) for advanced esophageal cancer. Thirteen patients with locally advanced esophageal cancer (T4 cases) and 3 with recurrence of esophageal cancer were treated with radiotherapy (40-70 Gy) and 5-FU combined and cisplatin/nedaplatin concurrently. T4 patients who obtained down-staging by CRT also underwent esophagectomy. A complete response was obtained in one case, partial response in 8 cases, and no change in 7 cases. The overall response rate was 56.3%. A pathological complete response was obtained in one case in which curative resection was performed after CRT. Bone marrow suppression was observed in 68.8% and grade 3 and 4 bone marrow suppression was observed in 43.8%. Concurrent CRT using cisplatin/nedaplatin and 5-FU for advanced esophageal cancer has a high response rate and patients obtaining down-staging by CRT as a neoadjuvant therapy have a chance for long survival after curative resection in locally advanced cases. (author)

  10. Prof. Elizaveta Karamihailova - The first lady of the Bulgarian physics (The contributions of prof. E. Karamihailova in radioactive studies)

    International Nuclear Information System (INIS)

    Balabanov, N.; Stoeva, M.; Lazarova, P.

    2012-01-01

    Prof. Elizaveta Karamihailova (1897-1968) is the first Bulgarian nuclear physicist and the first Bulgarian woman with an academic degree. Prof. Karamihajlova spent a significant period of time working at the Radium Institute in Vienna (1923-1935) and at the Cavendish Laboratory in Cambridge (1935-1939). She studies the nuclear reactions and the most up-to-date problems of the nuclear physics during the 1930's - neutron discovery, artificial radioactivity, split of atom nuclei. Following her return in Bulgaria (1939), E. Karamihailova continues the studies of Prof. P. Penchev to measure radioactivity of natural objects such as drinking and mineral water, soil, rocks, mud-curing. She also studies the radioactive pollution of the uranium mining regions, radioactivity due to nuclear tests. She is the founder of the first radiation protection activities in Bulgaria. (authors)

  11. The Relationship of Acculturation Strategies to Resilience: The Moderating Impact of Social Support among Qiang Ethnicity following the 2008 Chinese Earthquake.

    Science.gov (United States)

    Han, Li; Berry, John W; Zheng, Yong

    2016-01-01

    International research has mostly confirmed the positive association between acculturation strategies and resilience in ethnic groups, but the mediating and moderating mechanisms underlying the relationships are still under-investigated. The present study aimed to investigate the associations between acculturation strategies (based on two cultural identities) and resilience of 898 Qiang ethnicity volunteers (mean age = 29.5), especially exploring the mediating and moderating effects of personality, spiritual belief and social support on the relationship between acculturation strategy (using two cultural identities as latent variables in model analysis) and resilience following the occurrence of 2008 Wenchuan earthquake in Sichuan, taking such mechanisms into account. Results were as follows: (1) All variable presented significant positive correlations; (2) Consistent with the mediating hypotheses, personality and spiritual beliefs played a partial mediating role in the relationship between two cultural identities and resilience; (3) High or low level of perceived social support had a moderating effect on cultural identities and resilience; (4) The integration strategy was the most optimal style to promote the development of resilience, but marginalization was the least effective style.

  12. Experimental study of surface insulated-standard hybrid tungsten planar wire array Z-pinches at “QiangGuang-I” facility

    Energy Technology Data Exchange (ETDEWEB)

    Sheng, Liang; Peng, Bodong; Yuan, Yuan; Zhang, Mei; Zhao, Chen; Zhao, Jizhen; Wang, Liangping [State Key Laboratory of Intense Pulsed Radiation Simulation and Effect (Northwest Institute of Nuclear Technology), Xi' an 710024 (China); Li, Yang, E-mail: liyang@nint.ac.cn; Li, Mo [State Key Laboratory of Intense Pulsed Radiation Simulation and Effect (Northwest Institute of Nuclear Technology), Xi' an 710024 (China); Xi' an Jiaotong University, Xi' an 710049 (China)

    2016-01-15

    The experimental results of the insulated-standard hybrid wire array Z pinches carried out on “QiangGuang-I” facility at Northwest Institute of Nuclear Technology were presented and discussed. The surface insulating can impose a significant influence on the dynamics and radiation characteristics of the hybrid wire array Z pinches, especially on the early stage (t/t{sub imp} < 0.6). The expansion of insulated wires at the ablation stage is suppressed, while the streams stripped from the insulated wires move faster than that from the standard wires. The foot radiation of X-ray is enhanced by increment of the number of insulated wires, 19.6 GW, 33.6 GW, and 68.6 GW for shots 14037S, 14028H, and 14039I, respectively. The surface insulation also introduces nonhomogeneity along the single wire—the streams move much faster near the electrodes. The colliding boundary of the hybrid wire array Z pinches is bias to the insulated side approximately 0.6 mm.

  13. Itinerary for Prof. Nitash Balsara Arrival in Mumbai, November 4 ...

    Indian Academy of Sciences (India)

    RV

    2014-11-11

    Arrival in Mumbai, November 4. November 4-10 in and around Mumbai, will give lecture in IIT Bombay. November 11-15, in and around Kanpur, Prof Ashutosh Sharma will organize program. November 11, 2014. Mumbai-Lucknow: Air India AI-625; departs 10:30, reaches. 12:40. November 15, 2014. Lucknow-Bangalore.

  14. Wyle Prof H G Viljoen | Geyser | HTS Teologiese Studies ...

    African Journals Online (AJOL)

    HTS Teologiese Studies / Theological Studies. Journal Home · ABOUT · Advanced Search · Current Issue · Archives · Journal Home > Vol 9, No 2 (1953) >. Log in or Register to get access to full text downloads. Username, Password, Remember me, or Register. Wyle Prof H G Viljoen. A S Geyser. Abstract. No Abstract ...

  15. Prof. T. S. Sadasivan | History | About IASc | Indian Academy of ...

    Indian Academy of Sciences (India)

    Career: Univ. of Lucknow, Dept. of Botany: Demonstrator 40-41; Fruit and Vegetable Preservation Lab., Lyaupur: Microbiologist 41-44; Univ. of Madras, Centre for Ad-vanced Studies in Botany: Director/Prof. 44-73; CSIR, Plant-based Lab.: Consultant 73-76; Birbal Sahni Professor, Lucknow 77-80; Vidyashram, Kodaikanal: ...

  16. Weekly infusional high-dose fluorouracil (HD-FU), HD-FU plus folinic acid (HD-FU/FA), or HD-FU/FA plus biweekly cisplatin in advanced gastric cancer: randomized phase II trial 40953 of the European Organisation for Research and Treatment of Cancer Gastrointestinal Group and the Arbeitsgemeinschaft Internistische Onkologie.

    Science.gov (United States)

    Lutz, Manfred P; Wilke, Hansjochen; Wagener, D J Theo; Vanhoefer, Udo; Jeziorski, Krzysztof; Hegewisch-Becker, Susanna; Balleisen, Leopold; Joossens, Eric; Jansen, Rob L; Debois, Muriel; Bethe, Ullrich; Praet, Michel; Wils, Jacques; Van Cutsem, Eric

    2007-06-20

    This multicentric, randomized, two-stage phase II trial evaluated three simplified weekly infusional regimens of fluorouracil (FU) or FU plus folinic acid (FA) and cisplatin (Cis) with the aim to select a regimen for future phase III trials. A total of 145 patients with advanced gastric cancer where randomly assigned to weekly FU 3,000 mg/m2/24 hours (HD-FU), FU 2,600 mg/m2/24 hours plus dl-FA 500 mg/m2 or l-FA 250 mg/m2 (HD-FU/FA), or FU 2000 mg/m2/24 hours plus FA plus biweekly Cis 50 mg/m2, each administered for 6 weeks with a 1-week rest. The primary end point was the response rate. Confirmed responses were observed in 6.1% (two of 33) of the eligible patients treated with HD-FU, in 25% (12 of 48, including one complete remission [CR]) with HD-FU/FA, and in 45.7% (21 of 46, including four CRs) with HD-FU/FA/Cis. The HD-FU arm was closed after stage 1 because the required minimum number of responses was not met. The median progression-free survival of all patients in the HD-FU, HD-FU/FA, and HD-FU/FA/Cis arm was 1.9, 4.0, and 6.1 months, respectively. The median overall survival was 7.1, 8.9, and 9.7 months, and the survival rate at 1 year was 24.3%, 30.3%, and 45.3%, respectively. Grade 4 toxicities were rare. The most relevant grade 3/4 toxicities were neutropenia in 1.9%, 5.4%, and 19.6%, and diarrhea in 2.7%, 1.9%, and 3.9% of the cycles in the HD-FU, HD-FU/FA, and HD-/FU/Cis arms, respectively. Weekly infusional FU/FA plus biweekly Cis is effective and safe in patients with gastric cancer.

  17. Wavelet transform analysis of electromyography kung fu strikes data.

    Science.gov (United States)

    Neto, Osmar Pinto; Marzullo, Ana Carolina de Miranda

    2009-11-01

    In martial arts and contact sports strikes are performed at near maximum speeds. For that reason, electromyography (EMG) analysis of such movements is non-trivial. This paper has three main goals: firstly, to investigate the differences in the EMG activity of muscles during strikes performed with and without impacts; secondly, to assess the advantages of using Sum of Significant Power (SSP) values instead of root mean square (rms) values when analyzing EMG data; and lastly to introduce a new method of calculating median frequency values using wavelet transforms (WMDF). EMG data of the deltoid anterior (DA), triceps brachii (TB) and brachioradialis (BR) muscles were collected from eight Kung Fu practitioners during strikes performed with and without impacts. SSP results indicated significant higher muscle activity (p = 0.023) for the strikes with impact. WMDF results, on the other hand, indicated significant lower values (p = 0. 007) for the strikes with impact. SSP results presented higher sensitivity than rms to quantify important signal differences and, at the same time, presented lower inter-subject coefficient of variations. The result of increase in SSP values and decrease in WMDF may suggest better synchronization of motor units for the strikes with impact performed by the experienced Kung Fu practitioners. Key PointsThe results show higher muscle activity and lower electromyography median frequencies for strikes with impact compared to strikes without.SSP results presented higher sensitivity and lower inter-subject coefficient of variations than rms results.Kung Fu palm strikes with impact may present better motor units' synchronization than strikes without.

  18. Force, reaction time, and precision of Kung Fu strikes.

    Science.gov (United States)

    Neto, Osmar Pinto; Bolander, Richard; Pacheco, Marcos Tadeu Tavares; Bir, Cynthia

    2009-08-01

    The goal was to compare values of force, precision, and reaction time of several martial arts punches and palm strikes performed by advanced and intermediate Kung Fu practitioners, both men and women. 13 Kung Fu practitioners, 10 men and three women, participated. Only the men, three advanced and seven intermediate, were considered for comparisons between levels. Reaction time values were obtained using two high speed cameras that recorded each strike at 2500 Hz. Force of impact was measured by a load cell. For comparisons of groups, force data were normalized by participant's body mass and height. Precision of the strikes was determined by a high speed pressure sensor. The results show that palm strikes were stronger than punches. Women in the study presented, on average, lower values of reaction time and force but higher values of precision than men. Advanced participants presented higher forces than intermediate participants. Significant negative correlations between the values of force and precision and the values of force and reaction time were also found.

  19. WAVELET TRANSFORM ANALYSIS OF ELECTROMYOGRAPHY KUNG FU STRIKES DATA

    Directory of Open Access Journals (Sweden)

    Ana Carolina de Miranda Marzullo

    2009-11-01

    Full Text Available In martial arts and contact sports strikes are performed at near maximum speeds. For that reason, electromyography (EMG analysis of such movements is non-trivial. This paper has three main goals: firstly, to investigate the differences in the EMG activity of muscles during strikes performed with and without impacts; secondly, to assess the advantages of using Sum of Significant Power (SSP values instead of root mean square (rms values when analyzing EMG data; and lastly to introduce a new method of calculating median frequency values using wavelet transforms (WMDF. EMG data of the deltoid anterior (DA, triceps brachii (TB and brachioradialis (BR muscles were collected from eight Kung Fu practitioners during strikes performed with and without impacts. SSP results indicated significant higher muscle activity (p = 0.023 for the strikes with impact. WMDF results, on the other hand, indicated significant lower values (p = 0. 007 for the strikes with impact. SSP results presented higher sensitivity than rms to quantify important signal differences and, at the same time, presented lower inter-subject coefficient of variations. The result of increase in SSP values and decrease in WMDF may suggest better synchronization of motor units for the strikes with impact performed by the experienced Kung Fu practitioners

  20. Adoption, Cynical Detachment, and New Age Beliefs in Juno and Kung Fu Panda

    OpenAIRE

    Chen, Fu-jen

    2017-01-01

    In his article "Adoption, Cynical Detachment, and New Age Beliefs in Juno and Kung Fu Panda" Fu-Jen Chen situates his study within today's prevailing climate of global consumption to argue that the 2007 film Juno—featuring an unconventional portrayal of the adoption triad and a cynical detachment from public values—not only trivializes and depoliticizes the practice of adoption but also serves as an ideological supplement to today's global capitalism. Furthermore, Kung Fu Panda 1 & 2 (2008; 2...

  1. Andrographolide reversed 5-FU resistance in human colorectal cancer by elevating BAX expression.

    Science.gov (United States)

    Wang, Weicheng; Guo, Wenjie; Li, Lele; Fu, Zan; Liu, Wen; Gao, Jian; Shu, Yongqian; Xu, Qiang; Sun, Yang; Gu, Yanhong

    2016-12-01

    5-FU is the first line therapy for colorectal cancer, however, treatment effect is often hampered by the development of drug resistance or toxicity at high doses. Andrographolide is a natural diterpenoid from Andrographis paniculata which has anti-bacterial, anti-antiviral and anti-inflammation activities. In the current study, we test the hypothesis that Andrographolide reverses 5-FU resistance in colorectal cancer and examine the underlying mechanism. In vitro and vivo studies indicated that Andrographolide treatment significantly re-sensitizes HCT116/5-FUR cells (HCT116 cells which are 5-FU resistant) to cytotoxicity of 5-FU. Mechanism analysis showed that Andrographolide/5-FU co-treatment elevated apoptosis level of HCT116/5-FUR cells with highly increased level of BAX. By using biotin-Andrographolide pull down and cellular thermal shift assay, we found out that Andrographolide can directly target to BAX. Andrographolide-BAX interaction prevented BAX degradation, enhancing mitochondria-mediated apoptosis thus reversed 5-FU resistance while BAX silence diminished this effect. Further, by analyzing patient samples who received 5-FU involved chemotherapy, we found that expression level of BAX is correlated with PFS. Our results here provide a novel combination treatment strategy, especially for patients with 5-FU-resistant tumors expressing low level of BAX. Meanwhile, we also proposed that BAX expression may be a predicted and prognosis marker of 5-FU involved chemotherapy. Copyright © 2016 Elsevier Inc. All rights reserved.

  2. FuGEFlow: data model and markup language for flow cytometry

    Directory of Open Access Journals (Sweden)

    Manion Frank J

    2009-06-01

    Full Text Available Abstract Background Flow cytometry technology is widely used in both health care and research. The rapid expansion of flow cytometry applications has outpaced the development of data storage and analysis tools. Collaborative efforts being taken to eliminate this gap include building common vocabularies and ontologies, designing generic data models, and defining data exchange formats. The Minimum Information about a Flow Cytometry Experiment (MIFlowCyt standard was recently adopted by the International Society for Advancement of Cytometry. This standard guides researchers on the information that should be included in peer reviewed publications, but it is insufficient for data exchange and integration between computational systems. The Functional Genomics Experiment (FuGE formalizes common aspects of comprehensive and high throughput experiments across different biological technologies. We have extended FuGE object model to accommodate flow cytometry data and metadata. Methods We used the MagicDraw modelling tool to design a UML model (Flow-OM according to the FuGE extension guidelines and the AndroMDA toolkit to transform the model to a markup language (Flow-ML. We mapped each MIFlowCyt term to either an existing FuGE class or to a new FuGEFlow class. The development environment was validated by comparing the official FuGE XSD to the schema we generated from the FuGE object model using our configuration. After the Flow-OM model was completed, the final version of the Flow-ML was generated and validated against an example MIFlowCyt compliant experiment description. Results The extension of FuGE for flow cytometry has resulted in a generic FuGE-compliant data model (FuGEFlow, which accommodates and links together all information required by MIFlowCyt. The FuGEFlow model can be used to build software and databases using FuGE software toolkits to facilitate automated exchange and manipulation of potentially large flow cytometry experimental data sets

  3. FuGEFlow: data model and markup language for flow cytometry.

    Science.gov (United States)

    Qian, Yu; Tchuvatkina, Olga; Spidlen, Josef; Wilkinson, Peter; Gasparetto, Maura; Jones, Andrew R; Manion, Frank J; Scheuermann, Richard H; Sekaly, Rafick-Pierre; Brinkman, Ryan R

    2009-06-16

    Flow cytometry technology is widely used in both health care and research. The rapid expansion of flow cytometry applications has outpaced the development of data storage and analysis tools. Collaborative efforts being taken to eliminate this gap include building common vocabularies and ontologies, designing generic data models, and defining data exchange formats. The Minimum Information about a Flow Cytometry Experiment (MIFlowCyt) standard was recently adopted by the International Society for Advancement of Cytometry. This standard guides researchers on the information that should be included in peer reviewed publications, but it is insufficient for data exchange and integration between computational systems. The Functional Genomics Experiment (FuGE) formalizes common aspects of comprehensive and high throughput experiments across different biological technologies. We have extended FuGE object model to accommodate flow cytometry data and metadata. We used the MagicDraw modelling tool to design a UML model (Flow-OM) according to the FuGE extension guidelines and the AndroMDA toolkit to transform the model to a markup language (Flow-ML). We mapped each MIFlowCyt term to either an existing FuGE class or to a new FuGEFlow class. The development environment was validated by comparing the official FuGE XSD to the schema we generated from the FuGE object model using our configuration. After the Flow-OM model was completed, the final version of the Flow-ML was generated and validated against an example MIFlowCyt compliant experiment description. The extension of FuGE for flow cytometry has resulted in a generic FuGE-compliant data model (FuGEFlow), which accommodates and links together all information required by MIFlowCyt. The FuGEFlow model can be used to build software and databases using FuGE software toolkits to facilitate automated exchange and manipulation of potentially large flow cytometry experimental data sets. Additional project documentation, including

  4. Inhibition effects of a negative electret 5-FU patch on the growth of a hypertrophic scar

    Science.gov (United States)

    Wang, YUAN; Lili, XU; Ping, HUANG; Xiaoqiang, AN; Lili, CUI; Jian, JIANG

    2018-05-01

    In this study, the hypertrophic scar (HS) model in rats was established. 5-fluorouracil (5-FU) patch, ‑1000 V and ‑2000 V polypropylene (PP) electret 5-FU patches were prepared and applied onto the wound. The in vitro permeation experiment was performed using the Franz diffusion cell system to determine the permeation cumulative amount and retention amount of 5-FU through/in scar skin. The inhibition effect of negative electret on growth of HS was studied by hematoxylin-eosin (HE) staining, Masson staining and the immunohistologicall methods. The permeation study indicated that a negative electret could enhance the permeation and retention of 5-FU through and in scar skin respectively. HE staining and Masson staining indicated a better effect for ‑1000 V and ‑2000 V electret 5-FU patches on HS inhibition after 28 d post-wounding compared with 5-FU patch. The immunohistological study showed much more reduced expressions of collegan type I, collegan type III, TGF-β1 and HSP47 in scar tissue after application of negative electret 5-FU patches than those of 5-FU patch. A negative electret 5-FU patch may be advantageous for HS treatment.

  5. Remarks on Prof. Michał Kokowski’s comment about the studies into the life of Prof. Jan Czochralski (in Polish

    Directory of Open Access Journals (Sweden)

    Paweł E. TOMASZEWSKI

    2015-12-01

    Full Text Available Remarks on the critical comments regarding the contents of the paper published after the presentation delivered by the biographer of Prof. Jan Czochralski. Unfortunately, Prof. Kokowski used an incorrect historical approach to such a short paper. The remarks are presented in four main points.

  6. Professor ZHAN Qiang's Point-probe and Cannula Perfusion Treatment for Old Ankle Sprain%詹强教授治疗陈旧性踝关节扭伤的临床经验

    Institute of Scientific and Technical Information of China (English)

    寇智君; 崔太松; 陈东林; 詹强

    2017-01-01

    [目的]介绍詹强教授治疗陈旧性踝关节扭伤的独特经验,以供学习及参考.[方法]通过对陈旧性踝关节扭伤病因病机、探穴针罐灌注疗法理论、治疗方法、经典案例等几个方面进行论述,详细介绍詹强教授运用独创的探穴针罐灌注疗法治疗陈旧性踝关节扭伤的临床经验.[结果]詹强教授利用皮试针头在选取的经痹点平刺进针,进行不同深度、不同方向的多次探刺,并在皮下进行扫散,同时配合局部拔罐治疗,使瘀血得到消散,经络得到疏通,达到通则不痛的目的,治疗陈旧性踝关节扭伤有显著的疗效.[结论]詹强教授运用“探穴针罐灌注疗法”治疗陈旧性踝关节扭伤,经验独特,疗效显著,且安全性高,操作简单,值得临床推广应用.%[Objective] To introduce the Professor ZHAN Qiang treatment of old ankle arthritis of the unique experience of a systematic for others's learning and reference.[Methods]Through the etiology and pathogenesis of old ankle arthritis,probe the theory of point needle perfusion therapy,treatment methods,the classic case and several other aspects to introducte the clinical experience of Professor ZHAN Qiang use of their original point probe pot cannulation therapy for treatment of the old ankle sprain.[Result]Professor ZHAN Qiang using the skin test needle in the selected channel Bi points needle,with different depth and direction repeatedly,and combined with local cupping therapy,which can remove blood stasis and meridians get dredge.Therefore,treatment of old ankle sprain has a significant effect.[Conclusion]Professor ZHAN Qiang use of the "probe hole needle pot perfusion therapy"treatment of old ankle sprain has the advantage of unique experience,high safety,significant effect,and simple operation,so the clinical use of it should be promoted.

  7. Weekly infusional high-dose fluorouracil (HD-FU), HD-FU plus folinic acid (HD-FU/FA), or HD-FU/FA plus biweekly cisplatin in advanced gastric cancer: randomized phase II trial 40953 of the European Organisation for Research and Treatment of Cancer Gastrointestinal Group and the Arbeitsgemeinschaft Internistische Onkologie.

    NARCIS (Netherlands)

    Lutz, M.P.; Wilke, H.; Wagener, D.J.T.; Vanhoefer, U.; Jeziorski, K.; Hegewisch-Becker, S.; Balleisen, L.; Joossens, E.; Jansen, R.L.; Debois, M.; Bethe, U.; Praet, M.; Wils, J.; Cutsem, E. van

    2007-01-01

    PURPOSE: This multicentric, randomized, two-stage phase II trial evaluated three simplified weekly infusional regimens of fluorouracil (FU) or FU plus folinic acid (FA) and cisplatin (Cis) with the aim to select a regimen for future phase III trials. PATIENTS AND METHODS: A total of 145 patients

  8. 5FU and oxaliplatin-containing chemotherapy in two dihydropyrimidine dehydrogenase-deficient patients

    NARCIS (Netherlands)

    Reerink, O; Mulder, NH; Szabo, BG; Hospers, GAP

    2004-01-01

    Patients with a germline mutation leading to a deficiency of the dihydropyrimidine dehydrogenase (DPD) enzyme are at risk from developing severe toxicity on the administration of 5FU-containing chemotherapy. We report on the implications of this inborn genetic error in two patients who received 5FU

  9. Kung-fu versus swimming training and the effects on balance abilities in young adolescents.

    Science.gov (United States)

    Baccouch, Rym; Rebai, Haithem; Sahli, Sonia

    2015-11-01

    Our purpose is to investigate the static balance control of young adolescents practicing kung-fu and swimming in order to find out which of these physical activities is the most effective in developing specific balance abilities in young adolescents. Comparative experimental study. University laboratory research. Three groups of 11-13-year-old boys (12 practicing Kung-Fu, 12 practicing swimming and 12 controls). Center of pressure (CoP) excursions were registered in upright bipedal and unipedal stances on a stabilometric force platform in eyes open (EO) and eyes closed (EC) conditions. Kung-fu practitioners control their balance (P Kung-fu training improved (P kung-fu practitioners. Both of these physical activities could be recommended for young adolescents as recreational or rehabilitation programs as they develop specific balance abilities that could be important for improving and maintaining optimal health. Copyright © 2015 Elsevier Ltd. All rights reserved.

  10. THE NATURE AND EVOLUTIONARY STATE OF THE FU ORIONIS BINARY SYSTEM

    Energy Technology Data Exchange (ETDEWEB)

    Beck, Tracy L. [Space Telescope Science Institute, 3700 San Martin Drive, Baltimore, MD 21218 (United States); Aspin, C., E-mail: tbeck@stsci.edu, E-mail: caa@ifa.hawaii.edu [Institute for Astronomy, University of Hawaii, 640 North Aohoku Place, Hilo, HI 96720 (United States)

    2012-03-15

    In this paper, we present the results of our adaptive optics fed three-dimensional imaging spectroscopy study of the FU Orionis binary system. Although the 0.''5 separation companion to FU Ori is {approx}4 mag fainter, we have easily spatially resolved it in the J, H, and K infrared bands and extract high signal-to-noise spectra of the two stellar components from 1.15 to 2.4 {mu}m. We derive a spectral type of K5{sup +2}{sub -1} for FU Ori S based on the stellar photospheric absorption features and find that it is an actively accreting young star (M-dot{sub acc}{approx} (2-3) Multiplication-Sign 10{sup -8} M{sub Sun} yr{sup -1}) that is likely gravitationally bound to FU Ori. We have found that the continuum shape of FU Ori S is not well fit by our spectral modeling process, and this results in a large uncertainty in the line-of-sight extinction to the star. Yet, by placing FU Ori S on the Hertzsprung-Russell diagram and comparing its estimated location with evolutionary models, we find that it is best fit as a {approx}1.2 M{sub Sun} star with a likely age of less than {approx}2 Myr. If we assume coevality of the stellar components, we have thus placed an estimated age on the FU Ori system. Moreover, assuming the canonical model for the nature of FU Ori in that its optical and infrared absorption features arise primarily from the inner circumstellar disk around a {approx}0.3 M{sub Sun} star, we find that the fainter FU Ori S component is actually the more massive star in the system. Future monitoring of FU Ori S to investigate flux variability and orbital motion should further clarify the nature of this curious young binary.

  11. Prof. Manfred Popp, Chairman of the Executive Board, Forschungszentrum Karlsruhe GmbH

    CERN Multimedia

    Patrice Loïez

    2003-01-01

    Prof. Popp is pictured here in the ATLAS detector assembly hall with Dr. Horst Wenninger of CERN.Photo 01: Prof. Popp (right) and Dr. Wenninger in front of one of the two vacuum vessels for the ATLAS end-cap toroid magnets.Photo 02: Prof. Popp (right) and Dr. Wenninger in front of one of eight 25-metre-long aluminium-alloy coil casings that will house the racetrack coils of the barrel toroid magnet system.

  12. Characteristics of the Institute of Technology 'Prof. Jorge A. Sabato'

    International Nuclear Information System (INIS)

    Galvele, Jose R.

    2001-01-01

    A historical survey is made of the educational and training activities in metallurgy and material sciences carried out by the CNEA since 1962, that were the origin of the 'Prof. Jorge A. Sabato' Institute. Today the Institute, created by the CNEA in association with the National University of General San Martin, is preparing Engineers in Material Sciences and Masters and Ph. D. in Material Sciences and Technology (Mention in Physics and Material). The curricula of the studies are described in detail. The Information Center annexed to the Institute is also described

  13. γ-Tocotrienol prevents 5-FU-induced reactive oxygen species production in human oral keratinocytes through the stabilization of 5-FU-induced activation of Nrf2.

    Science.gov (United States)

    Takano, Hideyuki; Momota, Yukihiro; Kani, Kouichi; Aota, Keiko; Yamamura, Yoshiko; Yamanoi, Tomoko; Azuma, Masayuki

    2015-04-01

    Chemotherapy-induced oral mucositis is a common adverse event in patients with oral squamous cell carcinoma, and is initiated through a variety of mechanisms, including the generation of reactive oxygen species (ROS). In this study, we examined the preventive effect of γ-tocotrienol on the 5-FU-induced ROS production in human oral keratinocytes (RT7). We treated RT7 cells with 5-FU and γ-tocotrienol at concentrations of 10 µg/ml and 10 nM, respectively. When cells were treated with 5-FU alone, significant growth inhibition was observed as compared to untreated cells. This inhibition was, in part, due to the ROS gene-rated by 5-FU treatment, because N-acetyl cysteine (NAC), a ROS scavenger, significantly ameliorated the growth of RT7 cells. γ-tocotrienol showed no cytotoxic effect on the growth of RT7 cells. Simultaneous treatment of cells with these agents resulted in the significant recovery of cell growth, owing to the suppression of ROS generation by γ-tocotrienol. Whereas 5-FU stimulated the expression of NF-E2-related factor 2 (Nrf2) protein in the nucleus up to 12 h after treatment of RT7 cells, γ-tocotrienol had no obvious effect on the expression of nuclear Nrf2 protein. Of note, the combined treatment with both agents stabilized the 5-FU-induced nuclear Nrf2 protein expression until 24 h after treatment. In addition, expression of Nrf2-dependent antioxidant genes, such as heme oxygenase-1 (HO-1) and quinone oxidoreductase-1 (NQO-1), was significantly augmented by treatment of cells with both agents. These findings suggest that γ-tocotrienol could prevent 5-FU-induced ROS generation by stabilizing Nrf2 activation, thereby leading to ROS detoxification and cell survival in human oral keratinocytes.

  14. Characteristics of the Institute of Technology 'Prof. Jorge A. Sabato'; Caracteristicas del Instituto de Tecnologia 'Prof. Jorga A. Sabato'

    Energy Technology Data Exchange (ETDEWEB)

    Galvele, Jose R [Comision Nacional de Energia Atomica, General San Martin (Argentina). Centro Atomico Constituyentes

    2001-07-01

    A historical survey is made of the educational and training activities in metallurgy and material sciences carried out by the CNEA since 1962, that were the origin of the 'Prof. Jorge A. Sabato' Institute. Today the Institute, created by the CNEA in association with the National University of General San Martin, is preparing Engineers in Material Sciences and Masters and Ph. D. in Material Sciences and Technology (Mention in Physics and Material). The curricula of the studies are described in detail. The Information Center annexed to the Institute is also described.

  15. CONSTRAINING MASS RATIO AND EXTINCTION IN THE FU ORIONIS BINARY SYSTEM WITH INFRARED INTEGRAL FIELD SPECTROSCOPY

    International Nuclear Information System (INIS)

    Pueyo, Laurent; Hillenbrand, Lynne; Hinkley, Sasha; Dekany, Richard; Roberts, Jenny; Vasisht, Gautam; Roberts, Lewis C. Jr.; Shao, Mike; Burruss, Rick; Cady, Eric; Oppenheimer, Ben R.; Brenner, Douglas; Zimmerman, Neil; Monnier, John D.; Crepp, Justin; Parry, Ian; Beichman, Charles; Soummer, Rémi

    2012-01-01

    We report low-resolution near-infrared spectroscopic observations of the eruptive star FU Orionis using the Integral Field Spectrograph (IFS) Project 1640 installed at the Palomar Hale telescope. This work focuses on elucidating the nature of the faint source, located 0.''5 south of FU Ori, and identified in 2003 as FU Ori S. We first use our observations in conjunction with published data to demonstrate that the two stars are indeed physically associated and form a true binary pair. We then proceed to extract J- and H-band spectro-photometry using the damped LOCI algorithm, a reduction method tailored for high contrast science with IFS. This is the first communication reporting the high accuracy of this technique, pioneered by the Project 1640 team, on a faint astronomical source. We use our low-resolution near-infrared spectrum in conjunction with 10.2 μm interferometric data to constrain the infrared excess of FU Ori S. We then focus on estimating the bulk physical properties of FU Ori S. Our models lead to estimates of an object heavily reddened, A V = 8-12, with an effective temperature of ∼4000-6500 K. Finally, we put these results in the context of the FU Ori N-S system and argue that our analysis provides evidence that FU Ori S might be the more massive component of this binary system.

  16. CONSTRAINING MASS RATIO AND EXTINCTION IN THE FU ORIONIS BINARY SYSTEM WITH INFRARED INTEGRAL FIELD SPECTROSCOPY

    Energy Technology Data Exchange (ETDEWEB)

    Pueyo, Laurent [Johns Hopkins University, Department of Physics and Astronomy, 366 Bloomberg Center 3400 N. Charles Street, Baltimore, MD 21218 (United States); Hillenbrand, Lynne; Hinkley, Sasha; Dekany, Richard; Roberts, Jenny [Department of Astronomy, California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125 (United States); Vasisht, Gautam; Roberts, Lewis C. Jr.; Shao, Mike; Burruss, Rick; Cady, Eric [Jet Propulsion Laboratory, California Institute of Technology, 4800 Oak Grove Drive, Pasadena, CA 91109 (United States); Oppenheimer, Ben R.; Brenner, Douglas; Zimmerman, Neil [American Museum of Natural History, Central Park West at 79th Street, New York, NY 10024 (United States); Monnier, John D. [Department of Astronomy, University of Michigan, 941 Dennison Building, 500 Church Street, Ann Arbor, MI 48109-1090 (United States); Crepp, Justin [Department of Physics, 225 Nieuwland Science Hall, University of Notre Dame, Notre Dame, IN 46556 (United States); Parry, Ian [University of Cambridge, Institute of Astronomy, Madingley Road, Cambridge, CB3, OHA (United Kingdom); Beichman, Charles [NASA Exoplanet Science Institute, 770 South Wilson Avenue, Pasadena, CA 91225 (United States); Soummer, Remi [Space Telescope Science Institute, 3700 San Martin Drive, Baltimore, MD 21218 (United States)

    2012-09-20

    We report low-resolution near-infrared spectroscopic observations of the eruptive star FU Orionis using the Integral Field Spectrograph (IFS) Project 1640 installed at the Palomar Hale telescope. This work focuses on elucidating the nature of the faint source, located 0.''5 south of FU Ori, and identified in 2003 as FU Ori S. We first use our observations in conjunction with published data to demonstrate that the two stars are indeed physically associated and form a true binary pair. We then proceed to extract J- and H-band spectro-photometry using the damped LOCI algorithm, a reduction method tailored for high contrast science with IFS. This is the first communication reporting the high accuracy of this technique, pioneered by the Project 1640 team, on a faint astronomical source. We use our low-resolution near-infrared spectrum in conjunction with 10.2 {mu}m interferometric data to constrain the infrared excess of FU Ori S. We then focus on estimating the bulk physical properties of FU Ori S. Our models lead to estimates of an object heavily reddened, A{sub V} = 8-12, with an effective temperature of {approx}4000-6500 K. Finally, we put these results in the context of the FU Ori N-S system and argue that our analysis provides evidence that FU Ori S might be the more massive component of this binary system.

  17. 5-FU-hydrogel inhibits colorectal peritoneal carcinomatosis and tumor growth in mice

    International Nuclear Information System (INIS)

    Wang, Yongsheng; Gong, Changyang; Yang, Li; Wu, Qinjie; Shi, Shuai; Shi, Huashan; Qian, Zhiyong; Wei, Yuquan

    2010-01-01

    Colorectal peritoneal carcinomatosis (CRPC) is a common form of systemic metastasis of intra-abdominal cancers. Intraperitoneal chemotherapy is a preferable option for colorectal cancer. Here we reported that a new system, 5-FU-loaded hydrogel system, can improve the therapeutic effects of intraperitoneal chemotherapy. A biodegradable PEG-PCL-PEG (PECE) triblock copolymer was successfully synthesized. The biodegradable and temperature sensitive hydrogel was developed to load 5-FU. Methylene blue-loaded hydrogel were also developed for visible observation of the drug release. The effects and toxicity of the 5-FU-hydrogel system were evaluated in a murine CRPC model. The hydrogel system is an injectable flowing solution at ambient temperature and forms a non-flowing gel depot at physiological temperature. 5-FU-hydrogel was subsequently injected into abdominal cavity in mice with CT26 cancer cells peritoneal dissemination. The results showed that the hydrogel delivery system prolonged the release of methylene blue; the 5-FU-hydrogel significantly inhibited the peritoneal dissemination and growth of CT26 cells. Furthermore, intraperitoneal administration of the 5-FU-hydrogel was well tolerated and showed less hematologic toxicity. Our data indicate that the 5-FU-hydrogel system can be considered as a new strategy for peritoneal carcinomatosis, and the hydrogel may provide a potential delivery system to load different chemotherapeutic drugs for peritoneal carcinomatosis of cancers

  18. Ezra Pound and Du Fu: Gazing at Mt. Tai

    Directory of Open Access Journals (Sweden)

    Kent Su

    2017-08-01

    Full Text Available Confined to a six-by-six-foot outdoor steel cage, Ezra Pound saw a series of mountain hills from a few miles to the east of Pisa. The poet compared one of these small 800-metre hills to the sacred Chinese Mt. Tai, which becomes the most common geographical name in The Pisan Cantos. Pound’s poetic summoning of this particular mountain is related to the fact that Mt. Tai is historically and culturally connected to the philosophy of Confucius, who personally ascended the mountain several times. Pound, as a devout Confucian disciple, closely follows the philosophical doctrines and attempts to mentally trace the footsteps of Confucius. This paper will argue how Pound’s poetic evocation of the mountain shares a striking similarity to an eighth-century Chinese poem called “Gazing at Mt. Tai,” which was written by the famous literatus - Du Fu 杜甫(712 – 770 . In spite of living in two completely different eras and countries, Pound’s and Du Fu’s reference to Mt. Tai demonstrates the confluence of their poetic spirits. Neither of them ascended mountain personally. They instead made use of their poetic imagination to follow the paths of Confucius and perceived the mountain as an earthly paradise, one which represents tranquillity and serenity away from the moral and physical corruption of the external world.

  19. The Effect of 5-FU and Radiation on A549 Cells In Vitro

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Myung Za [Hanyang University College of Medicine, Seoul (Korea, Republic of); Chun, Ha Chong [Medical College of Virgina, Richmond (United States); Lee, Won Young [Yonsei University College of Medicine, Seoul (Korea, Republic of)

    1989-06-15

    Effects of ionizing radiation alone and combined with chemotherapy on tumor growth and it clonal specificity Monitored by changes in distribution of chromosome number were studies in A549 cell line originated from human adenocarcinoma of the lung. Radiation (300 rad, 600 rad and 900 rad) were delivered with or without 5-FU. Forty eight hours later, 57.5% of growth inhibition of cell was Seen in cells treated with 5-FU concentration of 0.47g/ml for 24 hr exposure. Cell survival carves after radiation with and without 5-FU were made. Chromosomal analysis of cells in metaphase in control, and in cells treated with 300 rad of radiation, or 0.47g/ml of 5-FU treatment, and combined treatment of cloth were 77ne to examine the changes in ploidy and number of chromosome. Radiation combined with 5-FU enhanced growth inhibition of A549 cells. However, no evidence of synergetic effects in growth inhibition was observed in the cells treated with the combination therapy. Pattern of chromosomal distribution of survived cells were shifted from hyperploidy to hypoploidy by single dose of radiation(300 rad). As radiation dose increased a large number of hypoploidy cells were observed. Following treatment of cells with 5-FU, chomosomal distribution of survived cells were also shifted to hypodiploidy, which were seen in cells treated with radiation. The cell treated with 5-FU and followed by radiation within 24 hrs had cell with increased number of hypodiploidy cells. Almost same type of chromosomal changes were reproduced in cells treated with combined treatment with radiation and 5-FU. Minor differences were that cells with fewer number of chromosome were more frequent in cells treated with combined therapy. Further increase in cells of hypoploidy(93%) having 1-10 chromosome were induced by additional radiation. Therefore, the enhanced therapeutic effect of 5-FU combined with radiation of A549 cells appeared to be additive rather than synergistic.

  20. Near fatal 5-FU gut toxicity post surgery--remarkable effect of high-dose sucralfate.

    Science.gov (United States)

    Toh, James Wei Tatt; Morris, David; Chen, Zhuoran; Chen, Cindy

    2015-06-01

    The objective of this review article and case report was to investigate the effectiveness of high-dose sucralfate on severe life-threatening 5-fluorouracil (5-FU) gut toxicity, with reference to, but not limited to dihydropyrimidine dehydrogenase (DPD) deficiency. A search was conducted on PubMed from 1950 to July 2013 for original studies on 5-FU gut toxicity and sucralfate. Studies were limited to human trials and English language and all articles included in this study were assessed with the application of predetermined selection criteria. Each article was then reviewed independently by two reviewers. A case report from our own centre was included in this review. From 33 results, 6 manuscripts were identified including 4 randomized controlled trial. One trial evaluated the use of sucralfate to alleviate stomatitis in patients with 5-FU-based chemotherapy. The other three trials evaluated the role of sucralfate in radiation toxicity. There was one case report which showed gastroscopy confirmed normalization of severe dysplastic erosive gastroduodenitis attributed to hepatic arterial infusion of 5-FU following a 2-month course of sucralfate and cimetidine and one case series showing clinical and sigmoidoscopically demonstrated improvement in ulcerative colitis in majority of patients receiving sucralfate enemas. There was no current literature specifically focussed on the role of sucralfate in 5-FU gut toxicity. Our case report describes the clinical course and successful treatment with sucralfate of a patient with Pseudomyxoma peritonei (PMP) who experienced 5-FU gut toxicity resulting in life-threatening bleeding due to presumed DPD deficiency post intraperitoneal 5-FU administration. This review article showed a lack of literature concerning the use of sucralfate in 5-FU gut toxicity. In our patient's case, sucralfate had a crucial role in the management of near fatal 5-FU gut toxicity, and further evaluation is required.

  1. Public Lecture | The long road to the LHC | Prof. Lyn Evans, Dr. Daniel Treille and Prof. Peter Jenni | 9 October

    CERN Document Server

    2014-01-01

    “The long road to the LHC” by Prof. Lyn Evans, Dr. Daniel Treille and Prof. Peter Jenni. Thursday 9 October, 7.30 p.m. in the Globe of Science and Innovation. Talk in English with simultaneous interpreting into French.  Entrance free. Limited number of seats. Reservation essential: +41 22 767 76 76 or cern.reception@cern.ch   Lyn Evans. Lecture by Lyn Evans Abstract The key to the discovery of the Higgs boson has been the development of particle accelerators at CERN over the years. I will explain how a particle accelerator works and will follow the path from the construction of the Proton Synchrotron in the 1950s to the world’s most powerful colliding beam machine, the Large Hadron Collider. Biography Born in 1945, Lyn Evans has spent his whole career in the field of high energy physics and particle accelerators, participating in all the great projects of CERN. From 1993 he led the team that designed, built and commissioned the LHC. He is currently ...

  2. Prof. Dr. Rer. Nat. Burkhard Rauhut - Rector of RWTH Aachen University - Germany sign the golden book of the CERN. Greeting from Mr Sigurd Lettow, CERN Chief Financial Officer and Prof. Carlo Rubbia (ex CERN Director-General).

    CERN Multimedia

    Maximilien Brice

    2007-01-01

    Prof. Dr. Rer. Nat. Burkhard Rauhut - Rector of RWTH Aachen University - Germany sign the golden book of the CERN. Greeting from Mr Sigurd Lettow, CERN Chief Financial Officer and Prof. Carlo Rubbia (ex CERN Director-General).

  3. [Professor Xu Fu-song's traditional Chinese medicine protocols for male diseases: A descriptive analysis].

    Science.gov (United States)

    Liu, Cheng-yong; Xu, Fu-song

    2015-04-01

    To analyze the efficacy and medication principles of Professor Xu Fu-songs traditional Chinese medicine (TCM) protocols for male diseases. We reviewed and descriptively analyzed the unpublished complete medical records of 100 male cases treated by Professor Xu Fu-song with his TCM protocols from 1978 to 1992. The 100 cases involved 32 male diseases, most of which were difficult and complicated cases. The drug compliance was 95%. Each prescription was made up of 14 traditional Chinese drugs on average. The cure rate was 32% , and the effective rate was 85%. Professor Xu Fu-song advanced and proved some new theories and therapeutic methods. Professor Xu Fu-song's TCM protocols can be applied to a wide range of male diseases, mostly complicated, and are characterized by accurate differentiation of symptoms and signs, high drug compliance, and excellent therapeutic efficacy.

  4. Asynchronous Sensor fuSion for Improved Safety of air Traffic (ASSIST), Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — SSCI proposes to develop, implement and test a collision detection system for unmanned aerial vehicles (UAV), referred to as the Asynchronous Sensor fuSion for...

  5. Identification of ALV-J associated acutely transforming virus Fu-J carrying complete v-fps oncogene.

    Science.gov (United States)

    Wang, Yixin; Li, Jianliang; Li, Yang; Fang, Lichun; Sun, Xiaolong; Chang, Shuang; Zhao, Peng; Cui, Zhizhong

    2016-06-01

    Transduction of oncogenes by ALVs and generation of acute transforming viruses is common in natural viral infections. In order to understand the molecular basis for the rapid oncogenicity of Fu-J, an acutely transforming avian leukosis virus isolated from fibrosarcomas in crossbreed broilers infected with subgroup J avian leukosis virus (ALV-J) in China, complete genomic structure of Fu-J virus was determined by PCR amplification and compared with those of Fu-J1, Fu-J2, Fu-J3, Fu-J4, and Fu-J5 reported previously. The results showed that the genome of Fu-J was defective, with parts of gag gene replaced by the complete v-fps oncogene and encoded a 137 kDa Gag-fps fusion protein. Sequence analysis revealed that Fu-J and Fu-J1 to Fu-J5 were related quasi-species variants carrying different lengths of v-fps oncogenes generated from recombination between helper virus and c-fps gene. Comparison of virus carrying v-fps oncogene also gave us a glimpse of the molecular characterization and evolution process of the acutely transforming ALV.

  6. Prof dr FJ van Zyl as mens, kerkman en godsdiensfilosoof

    Directory of Open Access Journals (Sweden)

    P. J. van der Merwe

    1989-01-01

    Full Text Available Prof Dr FJ van Zyl as person, church personality and philosopher of religion Professor Francois Jacobus van Zyl (1913-05-06 - served as Head of the Department of Science of Religion and Missiology, Faculty of Theology (Section: Nederduitsch Hervormde Kerk, University of Pretoria, during the period 1960-1978. This article (written by a former student of his and present Head of the same Department contains a short biography, a discussion of his views on Theology, Science of Religion and Philosophy of Religion, and a bibliography. He is portrayed as a theologian with Barthian convictions, while been influenced by Emil Brunner and to a lesser extent by Hendrik Kraemer also. His primary audience was the Nederduitsch Hervormde Kerk and his theological activities (especially in the period 1960-1983 must be seen in relation to his influential role in same church.

  7. Tegafur Substitution for 5-Fu in Combination with Actinomycin D to Treat Gestational Trophoblastic Neoplasm.

    Directory of Open Access Journals (Sweden)

    Mei Peng

    Full Text Available Although 5-fluorouracil (5-Fu combination chemotherapy provides a satisfactory therapeutic response in patients with gestational trophoblastic neoplasms (GTNs, it has severe side effects. The current study analyzed the therapeutic effects and side effects of tegafur plus actinomycin D (Act-D vs. 5-Fu plus Act-D for the treatment of GTNs based on controlled historical records. A total of 427 GTN cases that received tegafur and Act-D combination chemotherapy at the Second Xiangya Hospital of XiangYa Medical School between August 2003 and July 2013 were analyzed based on historical data. A total of 393 GTN cases that received 5-Fu plus Act-D between August 1993 and July 2003 at the same hospital were also analyzed, which constituted the control group. The therapeutic effects, toxicity and side effects after chemotherapy were compared between the groups. The overall response rate was 90.63% in the tegafur+Act-D group (tegafur group and 92.37% in the 5-Fu+Act-D group (5-Fu group; these rates were not significantly different (P > 0.05. However, the incidence rates of myelosuppression (white blood cell decline, gastrointestinal reactions (nausea, vomiting, dental ulcer, and diarrhea, skin lesions and phlebitis were lower in the tegafur group than in the 5-Fu group (P < 0.05. The results of this study may provide useful data for the clinical application of tegafur in GTN treatment.

  8. Characteristic patients with oral mucositis receiving 5-FU chemotherapy at Hasan Sadikin Hospital Bandung

    Directory of Open Access Journals (Sweden)

    Syarifah Fatimah

    2016-11-01

    Full Text Available Introduction: Oral mucositis is an inflammatory reaction of oral mucous membrane that often appears in cancer patients due to the chemotherapeutic agents, such as 5-fluorouracil (5-FU. The aim of this study was to describe the characteristic patients who receive 5-FU and had oral mucositis. Methods: This study was conducted on 41 patients with cancer receiving 5-FU chemotherapy at Dr Hasan Sadikin Hospital Bandung. The data was retrieved through interviews to find out patient’s characteristic; nutritional status examination by using body mass index measurement; and oral examination. Severity level was determined by using National Cancer Institute’s Common Toxicity Criteria scale, and the level of pain was measured by Numeric Pain Intensity Rating scale. Results: This research have shown 60,98% patient with cancer had received 5-FU chemotherapy treatment, and 44% with poor nutritional status (underweight. Oral mucositis was only found at non-keratinised mucous. The finding of this study was patients that receiving 5-FU chemotherapy treatment diagnosed with oral mucositis was on the 1st stadium (52% and the 2nd stadium (44% with the level of pain was on the mild level (48% and moderate level (32%.Conclusion: Oral mucositis was found on patients with cancer that received 5-FU chemotherapy with a variety of characteristics, nutritional statuses, locations, levels of severity and pain.

  9. Galactosylated nanostructured lipid carriers for delivery of 5-FU to hepatocellular carcinoma.

    Science.gov (United States)

    Varshosaz, Jaleh; Hassanzadeh, Farshid; Sadeghi, Hojjat; Khadem, Mostafa

    2012-09-01

    The aim of the present study was to design a targeted delivery system of 5-fluorouracil (5-FU) for hepatocellular carcinoma (HCC). Lactobionic acid (LB) was conjugated to stearyl amine (SA) by a chemical reaction. The nanostructured lipid carriers (NLCs), containing LB conjugate, lecithin, glyceryl monostearate, oil [oleic acid (OA) or Labrafac 5 or 10%], and 5-FU, were dissolved in alcohol/acetone, the oil phase was added to the aqueous phase containing Tween 80 or Solutol(®) HS15 (0.25 or 0.5%), and NLCs were prepared by an emulsification-solvent diffusion method. Physical properties and drug release were studied in NLCs. The thiazolyl blue tetrazolium bromide assay was used to study the cytotoxicity of NLCs on HepG(2) cells, and the cellular uptake of NLCs was determined by flow cytometry. Fourier transform infrared spectroscopy and (1)H-NMR spectra confirmed the successful conjugation of LB and SA. The optimized NLCs consisted of 0.5% Solutol HS15 and 10% OA oil. The particle size of these nanoparticles was 139.2 nm, with a zeta potential of -18 mV, loading efficiency of 34.2%, release efficiency after 2 hours of the release test was 72.6%, and crystallinity was 0.63%. The galactosylated NLCs of 5-FU were cytotoxic on the HepG(2) cell line in a half concentration of 5-FU and seems promising in reducing 5-FU dose in HCC.

  10. Prof. Richard Mattessich at 95. His Research Methodology

    Directory of Open Access Journals (Sweden)

    Giuseppe Galassi

    2017-12-01

    Full Text Available This paper is presented as a tribute to prof. Richard Mattessich. It is written “through the eyes” of a researcher who has worked closely with him over a period of 42 years, starting attending his courses of “Income Determination Theory” and “Research Methodology” at the University of British Columbia in 1975. Among his huge scientific research and publications, I intend to underline these three major contributions: (i Accounting metrics and other mathematical instruments which anticipated computer spreadsheet by 30 years; (ii. The preparation of accountants for information economics by means of analytical methods; and (iii The proposition of the “onion model of reality” to distinguish different Kind of reality. Este trabajo se presenta como un tributo al profesor Richard Mattessich. Está escrito “con los ojos” de un investigador que ha trabajado estrechamente con él durante un período de 42 años, comenzando a asistir a sus cursos de " Income Determination Theory" y "Research Methodology" en la Universidad de British Columbia en 1975. Entre su investigación y publicaciones, más importantes pretendo subrayar estas tres contribuciones principales: (i Accounting metrics and other mathematical instruments which anticipated computer spreadsheet by 30 years; (ii The preparation of accountants for information economics by means of analytical methods; y (iii The proposition of the “onion model of reality” to distinguish different Kind of reality.

  11. Overview of the Fusion Z-Pinch Experiment FuZE

    Science.gov (United States)

    Weber, T. R.; Shumlak, U.; Nelson, B. A.; Golingo, R. P.; Claveau, E. L.; McLean, H. S.; Tummel, K. K.; Higginson, D. P.; Schmidt, A. E.; UW/LLNL Team

    2016-10-01

    Previously, the ZaP device, at the University of Washington, demonstrated sheared flow stabilized (SFS) Z-pinch plasmas. Instabilities that have historically plagued Z-pinch plasma confinement were mitigated using sheared flows generated from a coaxial plasma gun of the Marshall type. Based on these results, a new SFS Z-pinch experiment, the Fusion Z-pinch Experiment (FuZE), has been constructed. FuZE is designed to investigate the scaling of SFS Z-pinch plasmas towards fusion conditions. The experiment will be supported by high fidelity physics modeling using kinetic and fluid simulations. Initial plans are in place for a pulsed fusion reactor following the results of FuZE. Notably, the design relies on proven commercial technologies, including a modest discharge current (1.5 MA) and voltage (40 kV), and liquid metal electrodes. Supported by DoE FES, NNSA, and ARPA-E ALPHA.

  12. Treating malfunction filtering bleb with repeated needling combined with adjunctive 5-FU after glaucoma filtration surgery

    Directory of Open Access Journals (Sweden)

    Yi Liu

    2013-07-01

    Full Text Available AIM: To evaluate the therapeutic efficacy of a repeated bleb needling technique combined with subconjunctival injection of 5-FU in eyes with previous glaucoma surgery that had malfunctional filtering blebs. METHODS: A retrospective review of 34 consecutive patients(34 eyesof repeated bleb needling combined with subconjunctival injection of 5-FU in eyes, which had malfunctional filtering blebs after previous glaucoma surgery in our hospital from March 2009 to February 2013 was performed. The intraocular pressures(IOP, shapes of filtering blebs and complications after surgery were analyzed. RESULTS: There was significant reduction of mean IOP from 35.51mmHg to 14.43mmHg(PCONCLUSION: Repeated needling with adjunctive 5-FU proved a highly effective, safe alternative to treat malfunctional filtering blebs after previous glaucoma surgery.

  13. Evolutionism through Chinese Eyes: Yan Fu, Ma Junwu and Their translations of Darwinian Evolutionism

    Directory of Open Access Journals (Sweden)

    Tsing-song Vincent Shen

    2015-04-01

    Full Text Available The huge impact that Darwinian Evolutionism has effected over Chinese intellectuals through Yan Fu's translation of Huxley's "Evolution and Ethics" into the Tianyanlun, is in fact based on Chinese traditional worldview on the one hand and the novel ideas it brings to the Chinese mind facing the challenge of transition. However, Yan Fu's translation is not as scientific as it should be when dealing with Huxley's discourse. Ma Junwu's translation of Darwin's "On the Origin of Species" attempts to be more scientific, in an effort to supply exact scientific terms and discourse in Chinese. However, at the end it is social Darwinism that has won the mind of the Chinese people. This paper analyses the ideas in Chinese past that leads to Chinese perception of Darwimism evolutionism and examines the ways it has been translated by Yan Fu and Ma Junwu.  

  14. High response rates following paclitaxel/5-FU and simultaneous radiotherapy in advanced head and neck carcinoma

    International Nuclear Information System (INIS)

    Schroeder, M.; Westerhausen, M.; Makoski, H.B.; Sesterhenn, K.; Schroeder, R.

    1997-01-01

    The main stay of treatment for head and neck cancer patients with advanced disease has been chemotherapy with Cisplatin/5-FU and simultaneous applied radiotherapy. With this multimodality treatment including radical surgery after two cycles of neoadjuvant chemotherapy and 40 Gy radiotherapy we reported 60% complete remission after 5 years for patients with stage III/IV of head and neck cancer. Paclitaxel, a new plant product, has demonstrated significant antineoplastic activity in head and neck tumors (ECOG-Study: 40% RR). Therefore we performed a trial with Taxol/5-FU and simultaneous radiation in a neoadjuvant and postoperative adjuvant setting of stage III/IV squamous cell carcinoma of the head and neck with pre-existent contraindication against Cisplatin. Patients and Methods: 30 patients with a primarily inoperable stage III/IV of SCC of the head and neck were enrolled to receive day 1 and 29 Taxol 175 mg/m 2 as a 3-hour-infusion, followed by 120-hour-cvi of 1000 mg/m 2 /d 5-FU. Locally irradiation was given ad 40 Gy (2 Gy/d/day 1-26). Radical surgery followed about day 56. Postoperatively patients received again 2 cycles of Taxol/5-FU and simultaneous irradiation with 30 Gy. Results: So far 30 patients were treated and all patients reached a CR after complete treatment, ongoing for 23/30 patients for 6 till 34 months: 4 patients developed a second neoplasia, and 3 patients gloved a local relapse. The principal toxicity was moderate (neutropenia, peripheral neuropathy, arthralgia/myalgia) and sensible with supportive care (e.g. PEG). Conclusions: The results suggest that the treatment of SCC of the head and neck with Taxol/5-FU and simultaneous radiation and radical surgery is a highly effective schedule and comparable with the treatment with Cisplatin/5-FU. (orig.) [de

  15. Evaluation of 5-FU pharmacokinetics in cancer patients with DPD deficiency using a Bayesian limited sampling strategy

    NARCIS (Netherlands)

    Van Kuilenburg, A.; Hausler, P.; Schalhorn, A.; Tanck, M.; Proost, J.H.; Terborg, C.; Behnke, D.; Schwabe, W.; Jabschinsky, K.; Maring, J.G.

    Aims: Dihydropyrimidine dehydrogenase (DPD) is the initial enzyme in the catabolism of 5-fluorouracil (5FU) and DPD deficiency is an important pharmacogenetic syndrome. The main purpose of this study was to develop a limited sampling strategy to evaluate the pharmacokinetics of 5FU and to detect

  16. Relationship between pharmacokinetics of 5-FU in plasma and in saliva, and toxicity of 5-fluorouracil/folinic acid

    NARCIS (Netherlands)

    Jansman, FGA; Coenen, JLLM; De Graaf, JC; Tobi, H; Sleijfer, DT; Brouwers, JRBJ

    2002-01-01

    Background: Dose adaptation based on pharmacokinetic parameters has been shown to decrease toxicity of some 5-fluorouracil(5-FU)-based continuous infusion regimens. Patients and Methods: In the present study the relationship between 5-FU pharmacokinetics in plasma and in saliva, and toxicity was

  17. MTHFR polymorphisms and 5-FU-based adjuvant chemotherapy in colorectal cancer

    DEFF Research Database (Denmark)

    Afzal, Shoaib; Jensen, S; Vainer, B

    2009-01-01

    Methylenetetrahydrofolate reductase is a pivotal enzyme in folate metabolism and 5-fluorouracil (5-FU) cytotoxicity. Two common single-nucleotide polymorphisms (SNPs), MTHFR 677C>T (rs1801133) and 1298A>C (rs1801131), reduce enzyme activity. Initially, these SNPs were claimed to predict clinical...

  18. [Mining analysis on composition and medication of menstruation prescriptions in Fu Qingzhu's Obstetrics and Gynecology].

    Science.gov (United States)

    Zhu, Jia-qing; Che, Yu-xia

    2015-04-01

    In this paper, menstruation prescriptions were selected from "Fu Qingzhu's Obstetrics and Gynecology" and analyzed by using GRI algorithm, correlation analysis, hierarchical clustering method through SPSS, Clementine and traditional Chinese medicine (TCM) inheritance auxiliary systems, in order to screen out 15 menopathy prescriptions, which involve 45 traditional Chinese medicine herbs. In the study, blood-tonifying and qi-tonifying herbs were found to be frequent in the prescriptions. The most frequent single herb was white paeony root, accounting for 9.6% in the total number of prescriptions; The most frequent herb pairs were white paeony root-radix rehmanniae preparata and paeony root-angelica sinensis. Among Fu Shan's menopathy prescriptions, 61 herbal pairs showed a correlation coefficient exceeding 0.05, which evolved into 16 pairs of core combinations. The analysis showed that menopathy prescriptions in volume 1 of "Fu Qingzhu's Obstetrics and Gynecology" focused on tonic traditional Chinese medicines involving liver, spleen and kidney and were adjusted according to changes in qi, blood, cold, hot and wet, which could provide a specific reference for further studies on Fu Shan's academic thoughts and traditional Chinese medicine clinical treatment of menopathy.

  19. The FU Orionis outburst as a thermal accretion event: Observational constraints for protostellar disk models

    Science.gov (United States)

    Bell, K. R.; Lin, D. N. C.; Hartmann, L. W.; Kenyon, S. J.

    1995-01-01

    The results of the time-dependent disk models developed in Bell & Lin are compared with observed properties of FU Orionis variables. Specific models are fit to the light curves of Fu Ori, V1515 Cyg, and V1057 Cyg. The slow risetime of V1515 Cyg can be matched by a self-regulated outburst model. The rapid risetimes of FU Ori and V1057 Cyg can be fitted with the application of modest perturbations to the disk surface density. Model disks display spectral features characteristic of observed objects. The color evolution of V1057 Cyg is naturally explained if mass flux drops in the inner disk (r less than 1/4 AU) while remaining steady in the outer disk. The decrease in optical line width (rotational velocity) observed during the decay of V1057 Cyg may be accounted for by an outward-propagating ionization front. We predict that before final decay to the quiescent phase, short-wavelength line widths (lambda less than 1.5 microns) will again increase. It is suggested that FU Orionis outbursts primarily occur to systems during the embedded phase with ages less than several times 10(exp 5) yr.

  20. The cardiovascular responses of male subjects to kung fu techniques. Expert/novice paradigm.

    Science.gov (United States)

    Jones, M A; Unnithan, V B

    1998-12-01

    The primary aim was to assess cardiovascular responses of expert and novice subjects to kung fu techniques. It was hypothesised that experienced subjects would demonstrate improved economy of movement during the techniques, evidenced by reduced exercise intensity. a comparative design was established utilising two groups; experienced (group E), and novice (group N). the experimentation took place under laboratory conditions, but was designed to maximise external validity. the only preselection variables were regular attendance at training and experience. Nine experienced males (group E, exp 9.5 +/- 5.2 yrs) and nine novice males (group N, exp 1.2 +/- 0.1 yrs) participated. The only exclusion guidelines were contraindications to participate within a maximal test, no subjects were excluded upon this basis. N/A. each subject participated in three kung fu protocols (forms, kicking and punching). Each protocol, randomly allocated, consisted of ten work (30 sec) and ten rest periods (30 sec). MEASURES taken during the protocols were heart rate (HR) and oxygen consumption (VO2). These were expressed as a percentage of maximal values to reflect exercise intensity. During both the form protocol and punching protocol group E were found to be working at a significantly (p kung fu techniques differ depending upon experience level. It is difficult to directly relate this to improved economy since work output could not be accurately quantified. It was also found that kung fu protocols elicited exercise intensity into the cardiovascular training zone.

  1. FuGeF: A Resource Bound Secure Forwarding Protocol for Wireless Sensor Networks.

    Science.gov (United States)

    Umar, Idris Abubakar; Mohd Hanapi, Zurina; Sali, A; Zulkarnain, Zuriati A

    2016-06-22

    Resource bound security solutions have facilitated the mitigation of spatio-temporal attacks by altering protocol semantics to provide minimal security while maintaining an acceptable level of performance. The Dynamic Window Secured Implicit Geographic Forwarding (DWSIGF) routing protocol for Wireless Sensor Network (WSN) has been proposed to achieve a minimal selection of malicious nodes by introducing a dynamic collection window period to the protocol's semantics. However, its selection scheme suffers substantial packet losses due to the utilization of a single distance based parameter for node selection. In this paper, we propose a Fuzzy-based Geographic Forwarding protocol (FuGeF) to minimize packet loss, while maintaining performance. The FuGeF utilizes a new form of dynamism and introduces three selection parameters: remaining energy, connectivity cost, and progressive distance, as well as a Fuzzy Logic System (FLS) for node selection. These introduced mechanisms ensure the appropriate selection of a non-malicious node. Extensive simulation experiments have been conducted to evaluate the performance of the proposed FuGeF protocol as compared to DWSIGF variants. The simulation results show that the proposed FuGeF outperforms the two DWSIGF variants (DWSIGF-P and DWSIGF-R) in terms of packet delivery.

  2. "Welch Schauspiel! Aber ach! ein Schauspiel : Fußball und Theater

    OpenAIRE

    Thiergen, Peter

    2009-01-01

    Der Essay zeigt, wie eng Fußball und Schauspiel/Theater/Drama zusammenhängen. Dabei wird nicht nur einer Vielzahl von sprachlichen und insbesondere metaphorischen Entsprechungen nachgespürt, in denen sich die beiden Publikumsereignisse wechselseitig interpretieren, sondern auch gezeigt, auf welchen medialen Grundlagen, Erfahrungen und Rezeptionsdispositionen diese Entsprechungen beruhen.

  3. Wheat germ agglutinin-functionalised crosslinked polyelectrolyte microparticles for local colon delivery of 5-FU

    DEFF Research Database (Denmark)

    Glavas-Dodov,, Marija; Steffansen, Bente; Srcarevska, Maja

    2013-01-01

    We have previously reported the development and characterisation of wheat germ agglutinin (WGA)-functionalised chitosan-Ca-alginate (CTS-Ca-ALG) microparticles (MPs) loaded with acid-resistant particles of 5-fluorouracil (5-FU). In the present work, our goal was to evaluate the potential of these......We have previously reported the development and characterisation of wheat germ agglutinin (WGA)-functionalised chitosan-Ca-alginate (CTS-Ca-ALG) microparticles (MPs) loaded with acid-resistant particles of 5-fluorouracil (5-FU). In the present work, our goal was to evaluate the potential......-Ca-ALG MPs and WGA conjugates. The concentration of 5-FU associated with Caco-2 cells was significantly greater when delivered from MPs. By incorporation of 5-FU into MPs and further decoration with WGA, an increased [methyl-³H]thymidine uptake was observed few hours after continuous drug treatment followed...... by significantly reduced uptake after 6 h. Gastrointestinal distribution was in favour of increased localisation and concentration of the particles in colon region....

  4. Protective effect of dexamethasone on 5-FU-induced oral mucositis in hamsters.

    Science.gov (United States)

    Ribeiro, Susana Barbosa; de Araújo, Aurigena Antunes; Araújo Júnior, Raimundo Fernandes de; Brito, Gerly Anne de Castro; Leitão, Renata Carvalho; Barbosa, Maisie Mitchele; Garcia, Vinicius Barreto; Medeiros, Aldo Cunha; Medeiros, Caroline Addison Carvalho Xavier de

    2017-01-01

    Oral mucositis (OM) is an important side effect of cancer treatment, characterized by ulcerative lesions in the mucosa of patients undergoing radiotherapy or chemotherapy, which has marked effects on patient quality of life and cancer therapy continuity. Considering that few protocols have demonstrated efficacy in preventing this side effect, the aim of this study was to examine the effect of dexamethasone (DEX) on OM induced by 5-fluorouracil (5-FU) in hamsters by studying signaling pathways. OM was induced in hamsters by 5-FU followed by mechanical trauma (MT) on day 4. On day 10, the animals were euthanized. The experimental groups included saline, MT, 5-FU, and DEX (0.25, 0.5, or 1 mg/kg). Macroscopic, histopathological, and immunohistochemical analyses as well as immunofluorescence experiments were performed on the oral mucosa of the animals. The oral mucosal samples were analyzed by enzyme-linked immunosorbent assays, and quantitative real-time polymerase chain reaction (qPCR). DEX (0.5 or 1 mg/kg) reduced inflammation and ulceration of the oral mucosa of hamsters. In addition, DEX (1 mg/kg) reduced the cytokine levels of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and macrophage migration inhibitory factor (MIF). DEX (1 mg/kg) also reduced the immunoexpression of cyclooxygenase (COX)-2, matrix metalloproteinase (MMP)-2, transforming growth factor (TGF)-β, MIF, Smad 2/3, Smad 2/3 phosphorylated and NFκB p65 in the jugal mucosa. Finally, DEX (1 mg/kg) increased interleukin-1 receptor-associated kinase 3 (IRAK-M), glucocorticoid-induced leucine zipper (GILZ), and mitogen-activated protein kinase (MKP1) gene expression and reduced NFκB p65 and serine threonine kinase (AKt) gene expression, relative to the 5-FU group. Thus, DEX improved OM induced by 5-FU in hamsters.

  5. Protective effect of dexamethasone on 5-FU-induced oral mucositis in hamsters.

    Directory of Open Access Journals (Sweden)

    Susana Barbosa Ribeiro

    Full Text Available Oral mucositis (OM is an important side effect of cancer treatment, characterized by ulcerative lesions in the mucosa of patients undergoing radiotherapy or chemotherapy, which has marked effects on patient quality of life and cancer therapy continuity. Considering that few protocols have demonstrated efficacy in preventing this side effect, the aim of this study was to examine the effect of dexamethasone (DEX on OM induced by 5-fluorouracil (5-FU in hamsters by studying signaling pathways. OM was induced in hamsters by 5-FU followed by mechanical trauma (MT on day 4. On day 10, the animals were euthanized. The experimental groups included saline, MT, 5-FU, and DEX (0.25, 0.5, or 1 mg/kg. Macroscopic, histopathological, and immunohistochemical analyses as well as immunofluorescence experiments were performed on the oral mucosa of the animals. The oral mucosal samples were analyzed by enzyme-linked immunosorbent assays, and quantitative real-time polymerase chain reaction (qPCR. DEX (0.5 or 1 mg/kg reduced inflammation and ulceration of the oral mucosa of hamsters. In addition, DEX (1 mg/kg reduced the cytokine levels of tumor necrosis factor (TNF-α, interleukin (IL-1β, and macrophage migration inhibitory factor (MIF. DEX (1 mg/kg also reduced the immunoexpression of cyclooxygenase (COX-2, matrix metalloproteinase (MMP-2, transforming growth factor (TGF-β, MIF, Smad 2/3, Smad 2/3 phosphorylated and NFκB p65 in the jugal mucosa. Finally, DEX (1 mg/kg increased interleukin-1 receptor-associated kinase 3 (IRAK-M, glucocorticoid-induced leucine zipper (GILZ, and mitogen-activated protein kinase (MKP1 gene expression and reduced NFκB p65 and serine threonine kinase (AKt gene expression, relative to the 5-FU group. Thus, DEX improved OM induced by 5-FU in hamsters.

  6. Anti-virus effect of traditional Chinese medicine Yi-Fu-Qing granule on acute respiratory tract infections.

    Science.gov (United States)

    Li, Anyuan; Xie, Yanying; Qi, Fanghua; Li, Jie; Wang, Peng; Xu, Shulan; Zhao, Lin

    2009-08-01

    Yi-Fu-Qing granule is a traditional Chinese medicine for the treatment of acute respiratory tract infections. The present study sought to investigate the anti-virus effects of Yi-Fu-Qing granule on acute respiratory infections with respiratory syncytial virus (RSV) and human adenoviruses type 3 (Ad3). The cytotoxicity of Yi-Fu-Qing granule was evaluated by the neutral red assay on HeLa cells. The antiviral effect of Yi-Fu-Qing granule was tested by observing the cytopathogenic effect (CPE) with a compound mixture of Isatis leaf as the positive control drug. The results indicated that the highest non-toxicity concentration of Yi-Fu-Qing granule on Hela cells was 1:100. The CPE reduction assay showed that Yi-Fu-Qing granule inhibited RSV and Ad3 replication at a concentration of 1:100. Thus, Yi-Fu-Qing granule may have a significant antivirus effect on acute respiratory tract infections with RSV and Ad3 infections and this could prove useful for further antivirus research on acute respiratory tract infections.

  7. A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu-Gli protein complexes.

    Science.gov (United States)

    Tukachinsky, Hanna; Lopez, Lyle V; Salic, Adrian

    2010-10-18

    In vertebrates, Hedgehog (Hh) signaling initiated in primary cilia activates the membrane protein Smoothened (Smo) and leads to activation of Gli proteins, the transcriptional effectors of the pathway. In the absence of signaling, Gli proteins are inhibited by the cytoplasmic protein Suppressor of Fused (SuFu). It is unclear how Hh activates Gli and whether it directly regulates SuFu. We find that Hh stimulation quickly recruits endogenous SuFu-Gli complexes to cilia, suggesting a model in which Smo activates Gli by relieving inhibition by SuFu. In support of this model, we find that Hh causes rapid dissociation of the SuFu-Gli complex, thus allowing Gli to enter the nucleus and activate transcription. Activation of protein kinase A (PKA), an inhibitor of Hh signaling, blocks ciliary localization of SuFu-Gli complexes, which in turn prevents their dissociation by signaling. Our results support a simple mechanism in which Hh signals at vertebrate cilia cause dissociation of inactive SuFu-Gli complexes, a process inhibited by PKA.

  8. My days as a student of Prof. Hao (1982-1986)

    Science.gov (United States)

    Ding, Mingzhou

    In 1982 I graduated from Peking University with a bachelor's degree in astrophysics. Passing the entrance exam the same year I became a graduate student in the Institute of Theoretical Physics (ITP), Chinese Academy of Sciences, with Prof. Hao Bailin as my advisor. More than 30 years have gone by. I often recall the days I spent at the ITP with great fondness. Classmates have become life-long friends. The lessons we have learned from Prof. Hao about research, scholarship and life continue to influence us today...

  9. PROF-TRAC D.4.1 Overview and structure of available material

    DEFF Research Database (Denmark)

    Larsen, Olena Kalyanova; Heiselberg, Per Kvols

    This report introduces available educational and training material from the recent IEE projects adapted in the PROF/TRAC repository. An explanation to the categorisation principle of the material in the repository is the key part of this report. The categorisation schema for educational material...... in the repository is developed using the skills and qualifications structure, developed in WP 2 of PROF/TRAC project. In this way the continuity of the work is well established and the achievements from between the work packages are harmonised....

  10. Pre-operative combined 5-FU, low dose leucovorin, and sequential radiation therapy for unresectable rectal cancer

    International Nuclear Information System (INIS)

    Minsky, B.D.; Cohen, A.M.; Kemeny, N.; Enker, W.E.; Kelsen, D.P.; Schwartz, G.; Saltz, L.; Dougherty, J.; Frankel, J.; Wiseberg, J.

    1993-01-01

    The authors performed a Phase 1 trial to determine the maximum tolerated dose of combined pre-operative radiation (5040 cGy) and 2 cycles (bolus daily x 5) of 5-FU and low dose LV (20 mg/m2), followed by surgery and 10 cycles of post-operative LV/5-FU in patients with unresectable primary or recurrent rectal cancer. Twelve patients were entered. The initial dose of 5-FU was 325 mg/m2. 5-FU was to be escalated while the LV remained constant at 20 mg/m2. Chemotherapy began on day 1 and radiation on day 8. The post-operative chemotherapy was not dose escalated; 5-FU: 425 mg/m2 and LV: 20 mg/m2. The median follow-up was 14 months (7--16 months). Following pre-operative therapy, the resectability rate with negative margins was 91% and the pathologic complete response rate was 9%. For the combined modality segment (preoperative) the incidence of any grade 3+ toxicity was diarrhea: 17%, dysuria: 8%, mucositis: 8%, and erythema: 8%. The median nadir counts were WBC: 3.1, HGB: 8.8, and PLT: 153000. The maximum tolerated dose of 5-FU for pre-operative combined LV/5-FU/RT was 325 mg/m2 with no escalation possible. Therefore, the recommended dose was less than 325 mg/m2. Since adequate doses of 5-FU to treat systemic disease could not be delivered until at least 3 months (cycle 3) following the start of therapy, the authors do not recommend that this 5-FU, low dose LV, and sequential radiation therapy regimen be used as presently designed. However, given the 91% resectability rate they remain encouraged with this approach. 31 refs., 1 fig., 2 tabs

  11. Tai Chi and Kung-Fu practice maintains physical performance but not vascular health in young versus old participants.

    Science.gov (United States)

    McAnulty, Steven; McAnulty, Lisa; Collier, Scott; Souza-Junior, Tacito P; McBride, Jeffrey

    2016-01-01

    Kung-Fu and Tai Chi along with other martial arts are gaining popularity but studies examining the benefits of martial arts on physical fitness, vascular health, nutrition, and psychological wellness are limited. Aging is associated with declines in these health components. The objectives of this study were to examine whether Tai Chi and Kung-Fu training would maintain physical fitness, vascular health, and psychological wellness components on older versus younger practitioners. Seventeen subjects were recruited and divided into Young (age Kung-Fu maintains physical fitness in older compared to younger practitioners. However, age associated changes in cardiovascular stiffness, systolic blood pressure, and pain were not prevented.

  12. The AKARI FU-HYU galaxy evolution program: first results from the GOODS-N field

    Science.gov (United States)

    Pearson, C. P.; Serjeant, S.; Negrello, M.; Takagi, T.; Jeong, W.-S.; Matsuhara, H.; Wada, T.; Oyabu, S.; Lee, H. M.; Im, M. S.

    2010-05-01

    The AKARI FU-HYU mission program carried out mid-infrared imaging of several well studied Spitzer fields preferentially selecting fields already rich in multi-wavelength data from radio to X-ray wavelengths filling in the wavelength desert between the Spitzer IRAC and MIPS bands. We present the initial results for the FU-HYU survey in the GOODS-N field. We utilize the supreme multiwavelength coverage in the GOODS-N field to produce a multiwavelength catalogue from infrared to ultraviolet wavelengths, containing more than 4393 sources, including photometric redshifts. Using the FU-HYU catalogue we present colour-colour diagrams that map the passage of PAH features through our observation bands. We find that the longer mid-infrared bands from AKARI (IRC-L18W 18 micron band) and Spitzer (MIPS24 24 micron band) provide an accurate measure of the total MIR emission of the sources and therefore their probable total mid-infrared luminosity. We also find that colours incorporating the AKARI IRC-S11 11 micron band produce a bimodal distribution where an excess at 11 microns preferentially selects moderate redshift star-forming galaxies. These powerful colour-colour diagnostics are further used as tools to extract anomalous colour populations, in particular a population of Silicate Break galaxies from the GOODS-N field showing that dusty starbursts can be selected of specific redshift ranges (z = 1.2-1.6) by mid-infrared drop-out techniques. The FU-HYU catalogue will be made publically available to the astronomical community.

  13. How Can Asian Snack FuLoi Plan Successful Entering to Greater Helsinki Area? : Market research

    OpenAIRE

    Nguyen, Loc

    2014-01-01

    This thesis introduces the significant factors of market research and its importance when considering doing international business. Furthermore, it could be useful for investors who have same favour to enter Finnish market. The case company is Asian Snack FuLoi- a German food industry company looking for new market. The goal of this study was to investigate the possibility for a company to enter Finland in general and Greater Helsinki in particular. The thesis was structured with theor...

  14. AN ANALYSIS OF THE ENVIRONMENTS OF FU ORIONIS OBJECTS WITH HERSCHEL

    Energy Technology Data Exchange (ETDEWEB)

    Green, Joel D.; Evans, Neal J. II; Merello, Manuel [Department of Astronomy, The University of Texas at Austin, 2515 Speedway, Stop C1400, Austin, TX 78712-1205 (United States); Kospal, Agnes [European Space Agency (ESA/ESTEC), Keplerlaan 1, 2200-AG Noordwijk (Netherlands); Herczeg, Gregory [Kavli Institute for Astronomy and Astrophysics, Peking University, Beijing 100871 (China); Quanz, Sascha P. [Institute for Astronomy, ETH Zurich, Wolfgang-Pauli-Strasse 27, CH-8093 Zurich (Switzerland); Henning, Thomas; Bouwman, Jeroen [Max Planck Institute for Astronomy, Koenigstuhl 17, D-69117 Heidelberg (Germany); Van Kempen, Tim A. [Leiden Observatory, Leiden University, P.O. Box 9513, 2300-RA Leiden (Netherlands); Lee, Jeong-Eun [Department of Astronomy and Space Science, Kyung Hee University, Gyeonggi 446-701 (Korea, Republic of); Dunham, Michael M. [Department of Astronomy, Yale University, New Haven, CT (United States); Meeus, Gwendolyn [Departamento de Fisica Teorica, Universidad Autonoma de Madrid, Campus Cantoblanco (Spain); Chen, Jo-hsin [Jet Propulsion Laboratory, Pasadena, CA (United States); Guedel, Manuel; Liebhart, Armin [Department of Astrophysics, University of Vienna (Austria); Skinner, Stephen L., E-mail: joel@astro.as.utexas.edu [Center for Astrophysics and Space Astronomy (CASA), University of Colorado, Boulder, CO 80309-0389 (United States)

    2013-08-01

    We present Herschel-HIFI, SPIRE, and PACS 50-670 {mu}m imaging and spectroscopy of six FU Orionis-type objects and candidates (FU Orionis, V1735 Cyg, V1515 Cyg, V1057 Cyg, V1331 Cyg, and HBC 722), ranging in outburst date from 1936 to 2010, from the 'FOOSH' (FU Orionis Objects Surveyed with Herschel) program, as well as ancillary results from Spitzer Infrared Spectrograph and the Caltech Submillimeter Observatory. In their system properties (L{sub bol}, T{sub bol}, and line emission), we find that FUors are in a variety of evolutionary states. Additionally, some FUors have features of both Class I and II sources: warm continuum consistent with Class II sources, but rotational line emission typical of Class I, far higher than Class II sources of similar mass/luminosity. Combining several classification techniques, we find an evolutionary sequence consistent with previous mid-IR indicators. We detect [O I] in every source at luminosities consistent with Class 0/I protostars, much greater than in Class II disks. We detect transitions of {sup 13}CO (J{sub up} of 5-8) around two sources (V1735 Cyg and HBC 722) but attribute them to nearby protostars. Of the remaining sources, three (FU Ori, V1515 Cyg, and V1331 Cyg) exhibit only low-lying CO, but one (V1057 Cyg) shows CO up to J = 23 {yields} 22 and evidence for H{sub 2}O and OH emission, at strengths typical of protostars rather than T Tauri stars. Rotational temperatures for 'cool' CO components range from 20 to 81 K, for {approx} 10{sup 50} total CO molecules. We detect [C I] and [N II] primarily as diffuse emission.

  15. Translation Methods Used In Writing Indonesian Subtitles Of “Kung Fu Panda Holiday”

    OpenAIRE

    NURMALLAH, HERDIANTI

    2013-01-01

    In Indonesia, western movies that are spoken in English make the need for Indonesian subtitles increase. To make subtitles in different language, translation has an important role. The translator must use appropriate methods to produce good translation. This study aims to find out the kinds of translation methods used in writing Indonesian subtitles of the movie “Kung Fu Panda Holiday” by using Newmark's theory (1988). This study uses descriptive qualitative approach with document analysis. T...

  16. Translasi Pencak Silat Kedalam Film Animasi (Studi Kasus Film Kung Fu Panda)

    OpenAIRE

    Riyo Ramadhan; Hafiz Aziz Ahmad; Alvanov Z. Mansoor

    2017-01-01

    Sebagai tradisi yang telah membudaya dari sejak zaman dahulu kala, pencak silat lahir sebagai benteng kekuatan pertahanan diri sekaligus menjadi seni yang memperkaya khazanah kebudayaan bangsa Indonesia. Namun, kuatnya terpaan kebudayaan seni bela diri impor yang masuk (karate, kung fu, tae kwon do, muay thai, capoeira, dll), yang selalu didukung dengan berbagai kemasan media entertainment modern, membuat silat menjadi kalah populer bahkan di mata dan persepsi masyarakat Indonesia sendiri. Ha...

  17. Posmodernisme Dalam Novel Generation X: Tales For Accelerated Culture Dan Bilangan Fu

    OpenAIRE

    Azmi, Nurul Nayla

    2013-01-01

    This research is entitled Postmodernism in Novel Generation X: Tale of Accelerated Culture and Bilangan Fu which analyze postmodernism as the concept in both novel. As generally known, that the fast growing of recent life has effecting the human’s life that change continuity started from traditional, modern and then to the latest which postmodernism. In the changing of each stage, human life also encounters the changing which may seen from happening social phenomenon. In the stage of postmo...

  18. Treatment results of chemoradiotherapy with 5-FU/CDGP for head and neck cancer

    International Nuclear Information System (INIS)

    Himei, Kengo; Katayama, Norihisa; Takemoto, Mitsuhiro; Kuroda, Masahiro; Nomiya, Shigenobu; Onoda, Tomoo; Tominaga, Susumu; Kanazawa, Susumu

    2006-01-01

    We investigated the safety and efficacy of alternative and concurrent chemoradiotherapy with 5-fluorouracil (FU)/nedaplatin (CDGP) for head and neck cancer. From January 2003 to August 2005, 19 patients with head and neck squamous cell carcinoma were treated in our institution. Alternative chemoradiotherapy (ACRT) was performed for 8 cases of nasopharyngeal cancer. Concurrent chemoradiotherapy (CCRT) was performed for 11 cases of other head and neck cancer. Median total dose of radiotherapy was 63 Gy. ACRT consisted of 5-FU at a dose of 500 mg/m 2 on days 1-5 and 28-32 and CDGP at a dose of 60 mg/m 2 on days 6 and 33. CCRT consisted of 5-FU at a dose of 500 mg/m 2 on days 1-4 and 28-31 and CDGP at a dose of 60 mg/m 2 on days 5 and 32. Median follow-up period was 13 months. CR+PR was admitted in five cases (63%) with ACRT, and in 9 cases (82%) with CCRT. Non-hematological adverse effects of grade 3 were admitted in eight cases (100%) of ACRT, and in 9 cases (82%) of CCRT. Chemoradiotherapy attained good results and non-hematological adverse effects were able to be managed by preserved treatment. (author)

  19. The Akt inhibitor ISC-4 synergizes with cetuximab in 5-FU-resistant colon cancer.

    Directory of Open Access Journals (Sweden)

    Joshua E Allen

    Full Text Available Phenylbutyl isoselenocyanate (ISC-4 is an Akt inhibitor with demonstrated preclinical efficacy against melanoma and colon cancer. In this study, we sought to improve the clinical utility of ISC-4 by identifying a synergistic combination with FDA-approved anti-cancer therapies, a relevant and appropriate disease setting for testing, and biomarkers of response. We tested the activity of ISC-4 and 19 FDA-approved anticancer agents, alone or in combination, against the SW480 and RKO human colon cancer cell lines. A synergistic interaction with cetuximab was identified and validated in a panel of additional colon cancer cell lines, as well as the kinetics of synergy. ISC-4 in combination with cetuximab synergistically reduced the viability of human colon cancer cells with wild-type but not mutant KRAS genes. Further analysis revealed that the combination therapy cooperatively decreased cell cycle progression, increased caspase-dependent apoptosis, and decreased phospho-Akt in responsive tumor cells. The synergism between ISC-4 and cetuximab was retained independently of acquired resistance to 5-FU in human colon cancer cells. The combination demonstrated synergistic anti-tumor effects in vivo without toxicity and in the face of resistance to 5-FU. These results suggest that combining ISC-4 and cetuximab should be explored in patients with 5-FU-resistant colon cancer harboring wild-type KRAS.

  20. Fluorescence and computational studies of thymidine phosphorylase affinity toward lipidated 5-FU derivatives

    Science.gov (United States)

    Lettieri, R.; D'Abramo, M.; Stella, L.; La Bella, A.; Leonelli, F.; Giansanti, L.; Venanzi, M.; Gatto, E.

    2018-04-01

    Thymidine phosphorylase (TP) is an enzyme that is up-regulated in a wide variety of solid tumors, including breast and colorectal cancers. It is involved in tumor growth and metastasis, for this reason it is one of the key enzyme to be inhibited, in an attempt to prevent tumor proliferation. However, it also plays an active role in cancer treatment, through its contribution in the conversion of the anti-cancer drug 5-fluorouracil (5-FU) to an irreversible inhibitor of thymidylate synthase (TS), responsible of the inhibition of the DNA synthesis. In this work, the intrinsic TP fluorescence has been investigated for the first time and exploited to study TP binding affinity for the unsubstituted 5-FU and for two 5-FU derivatives, designed to expose this molecule on liposomal membranes. These molecules were obtained by functionalizing the nitrogen atom with a chain consisting of six (1) or seven (2) units of glycol, linked to an alkyl moiety of 12 carbon atoms. Derivatives (1) and (2) exhibited an affinity for TP in the micromolar range, 10 times higher than the parent compound, irrespective of the length of the polyoxyethylenic spacer. This high affinity was maintained also when the compounds were anchored in liposomal membranes. Experimental results were supported by molecular dynamics simulations and docking calculations, supporting a feasible application of the designed supramolecular lipid structure in selective targeting of TP, to be potentially used as a drug delivery system or sensor device.

  1. Development of FuGO: An Ontology for Functional Genomics Investigations

    Science.gov (United States)

    Whetzel, Patricia L.; Brinkman, Ryan R.; Causton, Helen C.; Fan, Liju; Field, Dawn; Fostel, Jennifer; Fragoso, Gilberto; Gray, Tanya; Heiskanen, Mervi; Hernandez-Boussard, Tina; Morrison, Norman; Parkinson, Helen; Rocca-Serra, Philippe; Sansone, Susanna-Assunta; Schober, Daniel; Smith, Barry; Stevens, Robert; Stoeckert, Christian J.; Taylor, Chris; White, Joe; Wood, Andrew

    2009-01-01

    The development of the Functional Genomics Investigation Ontology (FuGO) is a collaborative, international effort that will provide a resource for annotating functional genomics investigations, including the study design, protocols and instrumentation used, the data generated and the types of analysis performed on the data. FuGO will contain both terms that are universal to all functional genomics investigations and those that are domain specific. In this way, the ontology will serve as the “semantic glue” to provide a common understanding of data from across these disparate data sources. In addition, FuGO will reference out to existing mature ontologies to avoid the need to duplicate these resources, and will do so in such a way as to enable their ease of use in annotation. This project is in the early stages of development; the paper will describe efforts to initiate the project, the scope and organization of the project, the work accomplished to date, and the challenges encountered, as well as future plans. PMID:16901226

  2. Changes in Editorial board Rhinology, Prof. Valerie Lund demits office as Editor in Chief of Rhinology

    NARCIS (Netherlands)

    Fokkens, W. J.

    2014-01-01

    At the Editorial Board Meeting of Rhinology Valerie Lund indicated that she has decided to emit office as Editor in Chief of Rhinology. She became a member of the editorial board in 1993, a co-editor with Prof. Bert Huizing in 1999 and Editor in Chief in 2004. She leaves with our grateful thanks for

  3. In memory Prof. Dr. L.H.K Bleeker | Gemser | HTS Teologiese ...

    African Journals Online (AJOL)

    HTS Teologiese Studies / Theological Studies. Journal Home · ABOUT THIS JOURNAL · Advanced Search · Current Issue · Archives · Journal Home > Vol 1, No 3 (1944) >. Log in or Register to get access to full text downloads. Username, Password, Remember me, or Register. In memory Prof. Dr. L.H.K Bleeker. B Gemser ...

  4. Highest recognition of Prof. N. Koga and further activities of Czech thermal analysis

    Czech Academy of Sciences Publication Activity Database

    Šesták, Jaroslav

    2013-01-01

    Roč. 573, Dec (2013), s. 158-161 ISSN 0040-6031 Grant - others:ZČP(CZ) ED2.1.00/03.0088 Institutional support: RVO:68378271 Keywords : prof. Koga * thermal analysis * thermodynamics * books * conferences Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 2.105, year: 2013

  5. PROF DR FELIX V. lATEGAN: Die Boer se Roer. Die Groot ...

    African Journals Online (AJOL)

    PROF DR FELIX V. lATEGAN: Die Boer se. Roer. Die Groot Geweerboek van Suid-. Afrika. Tafelberg. Uitgewers. Kaapstad, pp. 209, bibliografie, register. Sonder die Boer en sy roer is die geskiede:lis van ons land feitlik ondenkbc:wr en dit is clan ook vo/kome juis gesien dat die skrywer van hierdie baanbrekerswerk die ...

  6. PROF. ULRICH GERHARD LAUTS (1787— 1865). In sy studie „De ...

    African Journals Online (AJOL)

    Test

    In sy studie „De beteekenis van 1813 voor Nederlands geestelijke beschaving"') het die .... af te lê. Daarna het hulle hul eed nog weer bevestig om trou te bly aan ..... L. 'n ver dedigende skrywe aan die Minister gestuur na aanleiding van 'n twis met die militêre geneesheer („Rijksarchief," Dept. van Marine. Prof. U. G..

  7. A short life history of Prof. Dr. F.P. Jonker

    NARCIS (Netherlands)

    Janssen, C.R.

    1978-01-01

    This year Prof. Dr. F.P. Jonker, Frits as he is known among his friends, will retire from the formal academic life at the State University of Utrecht: a long and busy life of 49 years, devoted to teaching, administration, and scientific research. Looking back on all these years, one realises the

  8. The process of dissemination of kung fu in west – between sense of loss and inevitability loss of sense

    Directory of Open Access Journals (Sweden)

    Fernando Dandoro Castilho Ferreira

    2017-07-01

    Full Text Available In this paper, we discuss aspects of the development process of Kung Fu in China and its subsequent spread to the West in the light of sociological theory of Norbert Elias. To meet this goal, we have structured the text into three parts. In the first, we present some elements of theory of Elias that are useful to study Kung Fu. In the second part of the article, in turn, bring some evidence about the Kung Fu diffusion process to the West, taking as a reading aid work “Shaolin Monastery” of Meir Shahar. The third and final part of the text, we suggest that the reception of Kung Fu in the West engenders a social process that combines elements of Chinese tradition and capitalist modernity, giving the practice a hybrid and ambiguous character.

  9. Cell Line Derived 5-FU and Irinotecan Drug-Sensitivity Profiles Evaluated in Adjuvant Colon Cancer Trial Data

    DEFF Research Database (Denmark)

    Buhl, Ida Kappel; Gerster, Sarah; Delorenzi, Mauro

    2016-01-01

    patients who benefitted from the addition of irinotecan to 5-FU, we used gene expression profiles based on cell lines and clinical tumor material. These profiles were applied to expression data obtained from pretreatment formalin fixed paraffin embedded (FFPE) tumor tissue from 636 stage III colon cancer...... patients enrolled in the PETACC-3 prospective randomized clinical trial. A 5-FU profile developed similarly was assessed by comparing the PETACC-3 cohort with a cohort of 359 stage II colon cancer patients who underwent surgery but received no adjuvant therapy. RESULTS: There was no statistically...... to identify colon cancer patients who may benefit from 5-FU, however, any biomarker predicting benefit for adjuvant 5-FU must be rigorously evaluated in independent cohorts. Given differences between the two study cohorts, the present results should be further validated....

  10. EVIDENCE FOR AN FU ORIONIS-LIKE OUTBURST FROM A CLASSICAL T TAURI STAR

    International Nuclear Information System (INIS)

    Miller, Adam A.; Poznanski, Dovi; Silverman, Jeffrey M.; Kleiser, Io K. W.; Cenko, S. Bradley; Bloom, Joshua S.; Filippenko, Alexei V.; Hillenbrand, Lynne A.; Kasliwal, Mansi M.; Ofek, Eran O.; Quimby, Robert M.; Covey, Kevin R.; Rojas-Ayala, Barbara; Muirhead, Philip S.; Law, Nicholas M.; Dekany, Richard G.; Rahmer, Gustavo; Hale, David; Smith, Roger; Nugent, Peter

    2011-01-01

    We present pre- and post-outburst observations of the new FU Orionis-like young stellar object PTF 10qpf (also known as LkHα 188-G4 and HBC 722). Prior to this outburst, LkHα 188-G4 was classified as a classical T Tauri star (CTTS) on the basis of its optical emission-line spectrum superposed on a K8-type photosphere and its photometric variability. The mid-infrared spectral index of LkHα 188-G4 indicates a Class II-type object. LkHα 188-G4 exhibited a steady rise by ∼1 mag over ∼11 months starting in August 2009, before a subsequent more abrupt rise of >3 mag on a timescale of ∼2 months. Observations taken during the eruption exhibit the defining characteristics of FU Orionis variables: (1) an increase in brightness by ∼>4 mag, (2) a bright optical/near-infrared reflection nebula appeared, (3) optical spectra are consistent with a G supergiant and dominated by absorption lines, the only exception being Hα which is characterized by a P Cygni profile, (4) near-infrared spectra resemble those of late K-M giants/supergiants with enhanced absorption seen in the molecular bands of CO and H 2 O, and (5) outflow signatures in H and He are seen in the form of blueshifted absorption profiles. LkHα 188-G4 is the first member of the FU Orionis-like class with a well-sampled optical to mid-infrared spectral energy distribution in the pre-outburst phase. The association of the PTF 10qpf outburst with the previously identified CTTS LkHα 188-G4 (HBC 722) provides strong evidence that FU Orionis-like eruptions represent periods of enhanced disk accretion and outflow, likely triggered by instabilities in the disk. The early identification of PTF 10qpf as an FU Orionis-like variable will enable detailed photometric and spectroscopic observations during its post-outburst evolution for comparison with other known outbursting objects.

  11. High-Resolution Near-Infrared Spectroscopy of FU Orionis Objects

    Science.gov (United States)

    Hartmann, Lee; Hinkle, Kenneth; Calvet, Nuria

    2004-07-01

    We present an analysis of recent near-infrared, high-resolution spectra of the variable FU Ori objects. During a phase of rapid fading in optical brightness during 1997, V1057 Cyg exhibited shell absorption in first-overtone (v''-v'=2-0) CO lines, blueshifted by about 50 km s-1 from the system velocity. This shell component had not been seen previously, nor was it present in 1999, although some blueshifted absorption asymmetry is seen at the latter epoch. The appearance of this CO absorption shell is connected with the roughly contemporaneous appearance of blueshifted, low-excitation optical absorption lines with comparable low velocities; we suggest that this shell was also responsible for some of the peculiar emission features seen in red-optical spectra of V1057 Cyg. FU Ori continues to exhibit broad CO lines, with some evidence for the double-peaked profiles characteristic of an accretion disk; the line profiles are consistent with previous observations. Both FU Ori and V1057 Cyg continue to exhibit lower rotational broadening at 2.3 μm than at optical wavelengths, in agreement with the prediction of differentially rotating disk models; we have a marginal detection of the same effect in V1515 Cyg. The relative population of the first-overtone CO rotational levels in the FU Ori objects suggests low excitation temperatures. We compare disk models to the observations and find agreement with overall line strengths and rotational broadening, but the observed line profiles are generally less double-peaked than predicted. We suggest that the discrepancy in line profiles is due to turbulent motions in FU Ori disks, an effect qualitatively predicted by recent simulations of the magnetorotational instability in vertically stratified accretion disks. Based on observations obtained at the Gemini Observatory, which is operated by the Association of Universities for Research in Astronomy (AURA), Inc., under a cooperative agreement with the NSF, on behalf of the Gemini

  12. [Anti-tumor effect of 5-FU-PLLA-CNTs on human gastric carcinoma cell lines in vitro].

    Science.gov (United States)

    Gu, Jun; Li, Maolan; Wu, Xiangsong; Wu, Wenguang; Zhang, Lin; Ding, Qichen; Yang, Jiahua; Weng, Hao; Ding, Qian; Bao, Runfa; Shu, Yijun; Liu, Yingbin

    2014-04-01

    To prepare cisPLLAtin-loaded polylactic acid/cnts, and to study the anti-tumor effect of 5-FU-PLLA-CNTs on human gastric carcinoma cell lines(MGC803 and MNK45). 5-FU-PLLA-CNTs were prepared with ultrasound emulsification. The morphology of 5-FU-PLLA-CNTs was determined by scanning electron microscope(SEM), and its drug loading and drug release curve in vitro were detected by UV-Vis-NIR spectrophotometer. Cells were divided into experiment, positive control and negative control groups. CCK8 method was used to test the cytotoxic effect of 5-FU-PLLA-CNTs in different concentrations on MGC803 and MNK45 cell proliferation. Flow cytometry was employed to measure the apoptotic rate of MGC803 and MNK45 cells before and after the intervention of 5-FU-PLLA-CNTs. Deep layer film of 5-FU-PLLA-CNTs was successfully established, whose drug-load rate was(4.54±0.43)%, entrapment rate was(21.56±2.36)%. In vitro release test showed release rate within 24 h of 5-FU-PLLA-CNTs was 23.9% in a as lowly increasing manner, and accumulating release rate was 85.3% at day 31. CCk8 experiment revealed, as compared to control group, 5-FU-PLLA-CNTs significantly inhibited the proliferation of two cell lines in dose-dependent and time-dependent manner. The best 5-FU-PLLA-CNTs concentration of inhibition for human gastric cancer cell lines was 1 mg/well. Flow cytometry indicated the apoptotic rate of MGC803 and MNK45 cells in experiment group treated by 1 mg/well 5-FU-PLLA-CNTs significantly increased as compared to negative control group (P0.05). The 5-FU-PLLA-CNTs has good drug sustained-release capacity, and can significantly kill and inhibit the proliferation of MGC803 and MNK45 cell lines.

  13. Drucken Images und mediale Diskurse über afrikanischen Fußball: Paternalismus, Rassismus und neoliberale Bewunderung

    Directory of Open Access Journals (Sweden)

    Kurt Wachter

    2010-03-01

    Full Text Available Die Wahrnehmung des afrikanischen Fußballs und seiner Spieler war und ist sowohl in den Stadien wie in den medialen Darstellungen von rassistischen Images aus der Zeit Kolonialismus geprägt. Der speziell in Europa konstatierbare Aufstieg des afrikanischen Fußballs im Zuge der Ökonomisierung und Globalisierung des Spiels brachte zwar neue Superstars hervor, alte Stereotype leben aber vor Ort wie im medialen Diskurs in transformierter Weise fort.

  14. Site Wellenberg: ENSI's view on the expert report by Prof. Jon Mosar

    International Nuclear Information System (INIS)

    2011-08-01

    A public consultation on Stage 1 of the Sectoral Plan 'Deep Geological Disposal' (SGT) aiming at identifying the best site location, took place in Switzerland. In the framework of the elaboration of a report on this consultation by the Swiss Federal Office of Energy (BFE), the Swiss Federal Nuclear Safety Inspectorate (ENSI) had to discuss the safety relevant objections. In addition to its own memorandum, the government of the Canton of Nidwalden entered the expert report 'Assessment of the tectonics of the site region Wellenberg (Ct. NW/OW) with regard to a deep repository for low- and intermediate-level radioactive wastes' by Prof. Jon Mosar (University of Fribourg/CH). In his expert report, Mosar concludes that, globally considered, this site should be declared as inappropriate. In the present report, ENSI gives a detailed evaluation of this expert report. In its evaluation, ENSI was supported by the Swiss Seismological Service (SED) that checked Prof. Mosar's statements about the seismicity. SED came up to the conclusion that Prof. Mosar's statements are basically correct. But the allocation of the seismic events to single structural components, as Prof. Mosar did, is not possible because of the large inaccuracies in the localization of the hypocentres. From the SED statements it further comes out that the data set used earlier by the National Cooperative for the Disposal of Radioactive Waste (NAGRA) is in agreement with the seismic events that have been observed meanwhile. A series of smaller seismic events during the year 2005 in conjunction with strong rain falls in the region, constitutes, however, a notable exception. The strength of such a seismic activity is limited. The expert report by Prof. Mosar is restricted to the aspects of tectonics and seismicity. For a complete evaluation of the aptitude of the site region, all 13 safety technical criteria required by the Sectoral Plan SGT should be evaluated and that was not done in the present expert report

  15. Report on visit from Prof. Kim Lutzen: Friday, 6 November 1998, Korolinska Institute (dept of nursing Stockholm, Sweden

    Directory of Open Access Journals (Sweden)

    Kim Lutzen

    1999-10-01

    Full Text Available Prof. Kim Lutzen contacted the Department of Advanced Nursing Sciences, Unisa, via the Department's Web Page. Prof. Lutzen is the Chair of the Department of Nursing, which offers undergraduate, master and doctoral programmes. This Department of Nursing is situated within the Karolinska Institute, which comprises 29 Departments of Health Sciences, including a number of Medical Departments, Dentistry, Occupational Therapy, Physiotherapy, and Nursing. Prof. Lutzen emphasised that there is no Swedish phrase similar to "nursing science", consequently this t e n seems to be somewhat unfamiliar to the Swedish nurses. *Please note: This is a reduced version of the abstract. Please refer to PDF for full text.

  16. Radio-chemo-therapy with 5FU and cisplatin for bladder cancer after TUR-bladder

    International Nuclear Information System (INIS)

    Schuchardt, U.; Birkenhake, S.; Leykam, S.; Martus, P.; Sauer, R.

    1996-01-01

    Purpose/Objective: To determine toxicity and efficacy of radio-chemo-therapy (RCT) with 5FU and cisplatin in patients with bladder cancer. Endpoints are initial response, cystectomy-rates and overall-survival. Materials and Methods: From 11/93 to 1/95 13 patients suffering from bladder cancer were first treated with TUR-bladder (TURB). Patient characteristics were as follows: Within 6 weeks after operation the pelvis was irradiated with 54.0 Gy (median) in conventional fractionation (10 MV photons 4-field-box). The bladder was boosted up to 59.4 Gy (median) in isocentric rotation technique. 7 patients were treated with 45 Gy paraaortal. During the first and 5th treatment week chemotherapy (CT) was simultaneously given: 800 mg/m 2* d CISPLATIN as bolus-infusion 30 min prior to RT. 2 months later a further TURB was performed for restaging. Cystectomy was recommended, if invasive cancer was found at this time. Acute hematological and gastrointestinal toxicity was recorded according to the WHO-criteria. Results: At least 81% (e.g. 75% of 2nd course) of CT was applied in 10/13 patients. Median doses were 3500 mg/m 2 5FU and 200 mg/m 2 CISPLATIN. Acute toxicity to bladder and bowel reached grade 2 WHO only. Hematotoxicity (median values) and results ar shown in the following table. Conclusion: Concomitant RCT with 5FU and CISPLATIN seems to be a promising modality for organ-preserving therapy of bladder cancer. Preliminary results show sufficient effect and acceptable toxicity. Since patient number is still low, further investigation is recommended

  17. A inserção do kung fu no Brasil na perspectiva dos mestres pioneiros

    OpenAIRE

    Ferreira, Fernando Dandoro Castilho

    2013-01-01

    Resumo: Discutir atualmente a China e sua cultura parece algo bastante útil, principalmente em decorrência da sua posição econômica, que exerce uma impactante influência mundial. Para buscar trazer alguma luz sobre a China, fizemos uso de um marcante e elucidativo elemento de sua cultura, a sua arte marcial. Mais ainda, buscamos avançar neste processo tratando não do Kung Fu em seu berço de origem, mas sim, olhando-o em sua vertente contemporânea, oriunda do processo de disseminação deste em ...

  18. Electrochemical degradation of 5-FU using a flow reactor with BDD electrode: Comparison of two electrochemical systems.

    Science.gov (United States)

    Ochoa-Chavez, A S; Pieczyńska, A; Fiszka Borzyszkowska, A; Espinoza-Montero, P J; Siedlecka, E M

    2018-06-01

    In this study, the electrochemical degradation process of 5-fluorouracil (5-FU) in aqueous media was performed using a continuous flow reactor in an undivided cell (system I), and in a divided cell with a cationic membrane (Nafion ® 424) (system II). In system I, 75% of 5-FU degradation was achieved (50 mg L -1 ) with a applied current density j app  = 150 A m -2 , volumetric flow rate qv = 13 L h -1 , after 6 h of electrolysis (k app  = 0.004 min -1 ). The removal efficiency of 5-FU was higher (95%) when the concentration was 5 mg L -1 under the same conditions. Nitrates (22% of initial amount of N), fluorides (27%) and ammonium (10%) were quantified after 6 h of electrolysis. System II, 77% of 5-FU degradation was achieved (50 mg L -1 ) after 6 h of electrolysis (k app  = 0.004 min -1 ). The degradation rate of 5-FU was complete when the concentration was 5 mg L -1 under the same conditions. Nitrates (29% of initial amount of N), fluorides (25%) and ammonium (5%) were quantified after 6 h of electrolysis. In addition, the main organic byproducts identified by mass spectroscopy were aliphatic compound with carbonyl and carboxyl functionalities. Due to, the mineralization of 5-FU with acceptable efficiency of 88% found in system II (j app of 200 A m -2 ), this system seems to be more promising in the cytostatic drug removal. Moreover the efficiency of 5-FU removal in diluted solutions is better in system II than in system I. Copyright © 2018 Elsevier Ltd. All rights reserved.

  19. CTGF enhances resistance to 5-FU-mediating cell apoptosis through FAK/MEK/ERK signal pathway in colorectal cancer

    Directory of Open Access Journals (Sweden)

    Yang K

    2016-11-01

    Full Text Available Kai Yang, Kai Gao, Gui Hu, Yanguang Wen, Changwei Lin, Xiaorong Li Department of General Surgery, The Third Affiliated Hospital of Central South University, Central South University, Changsha, Hunan, People’s Republic of China Abstract: Colorectal cancer (CRC is one of the most commonly diagnosed cancers among both males and females; the chemotherapy drug 5-fluorouracil (5-FU is one of a doctors’ first lines of defense against CRC. However, therapeutic failures are common because of the emergence of drug resistance. Connective tissue growth factor (CTGF is a secreted protein that binds to integrins, and regulates the invasiveness and metastasis of certain carcinoma cells. Here, we found that CTGF was upregulated in drug-resistant phenotype of human CRC cells. Overexpression of CTGF enhanced the resistance to 5-FU-induced cell apoptosis. Moreover, downregulating the expression of CTGF promoted the curative effect of chemotherapy and blocked the cell cycle in the G1 phase. We also found that CTGF facilitated resistance to 5-FU-induced apoptosis by increasing the expression of B-cell lymphoma-extra large (Bcl-xL and survivin. Then we pharmacologically blocked MEK/ERK signal pathway and assessed 5-FU response by MTT assays. Our current results indicate that the expression of phosphorylated forms of MEK/ERK increased in high CTGF expression cells and MEK inhibited increases in 5-FU-mediated apoptosis of resistant CRC cells. Therefore, our data suggest that MEK/ERK signaling contributes to 5-FU resistance through upstream of CTGF, and supports CRC cell growth. Comprehending the molecular mechanism underlying 5-FU resistance may ultimately aid the fight against CRC. Keywords: connective tissue growth factor, 5-fluorouracil, mitogen-activated protein kinase/extracellular regulated protein kinases, phosphatidyl inositol 3-kinase/serine/threonine kinase Akt, colorectal cancer

  20. Gambaran Motivasi Perawat Dalam Melakukan Dokumentasi Keperawatan Di RSUD Prof. Dr. Margono SOekarja Purwokerto

    OpenAIRE

    Triyanto, Endang; Kamaluddin, Ridlwan

    2008-01-01

    Nurse activity can be seen at nursing documentation result. It's consist anamneses study, diagnose, planning, implementation and evaluation. Therefore nurse activity is one of quality service in hospital. This matter still need attention for nurse. The aim of this research was to know data motivate nurse to do nursing documentation in Prof. Dr. Margono Soekardjo Hospital of Purwokerto.Research study is survey with sectional cross. Research population is nurse take care of to lodge in RSUD Pro...

  1. 11th June 2009-Cyprus-Minister of Education and Culture H. E. Prof. Andreas Demetriou

    CERN Multimedia

    Maximilien Brice

    2009-01-01

    Tirage 1 :CERN Director-General, R. Heuer and Minister of Education and Culture, H. E. Prof. Andreas Demetriou; Tirage 2:Council President,T. Åkesson, Ecole Normale Supérieure,K. Kounnas, Chairman of the Cyprus CERN Committee,C. N. Papanicolas, R. Heuer,A. Demetriou, Permanent Representative of the Republic of Cyprus in Geneva,A. Hadjichrysanthou, Directorate Office,E. Tsesmelis

  2. Dr Luigi Orlando, Dr Sergio Ceccuzzi, Dr. Armando Sbrana, Europa Metalli, Italy, Dr Albert Scherger, Member of KM Europa Metal AG, Osnabr ck, Germany, Prof. Filippo Menzinger, Scientific Attaché, Permanent Mission of Italy in Geneva

    CERN Multimedia

    Patrice Loïez

    2001-01-01

    Photo 01: Dr Lyn Evans and Dr Luigi Orlando Photo 04: L. to r.: Dr Lyn Evans, Dr Luigi Orlando, Prof. Luciano Maiani and Prof. Filippo Menzinger Photo 06: L. to r.: Prof. Philippo Menzinger, Dr Armando Sbrana, Prof. Luciano Maiani, Dr Albert Scherger, Dr Lyn Evans, Dr Luigi Orlando, Dr Sergio Ceccuzzi, visiting the LHC superconducting magnet test hall, SM18

  3. Nedaplatin and 5-FU combined with radiation in the treatment for esophageal cancer

    International Nuclear Information System (INIS)

    Yamanaka, Hideharu; Motohiro, Takayuki; Michiura, Taku; Asai, Akira; Mori, Tsuyoshi; Hioki, Koshiro

    1998-01-01

    A series of patients with esophageal cancer was treated with chemotherapeutic regimens of the new antitumor platinum preparation nedaplatin plus 5-FU in combination with radiation therapy, and the therapeutic responses, side effects, and complications were clinically assessed. There were 2 patients with a complete response and 11 patients with a partial response, hence, a response rate of 76.5%. Major adverse reactions were those of hematological toxicity and included leukopenia (13 patients, 76.5%), thrombocytopenia (8 patients, 47.1%), and lowered serum hemoglobin concentration (9 patients, 52.9%). The leukopenia and thrombocytopenia, though of a grade 3 severity in 3 and 2 patients, respectively, subsided spontaneously in all affected cases. Gastrointestinal adverse reactions were mild and included appetite loss in 7 patients (41.2%) and nausea in 2 patients (11.8%). The only abnormality in renal function observed was a slight elevation of serum creatinine in one patient. The combined therapy of chemotherapy with nedaplatin and 5-FU plus radiation produced a high response rate in the treatment of carcinoma of the esophagus and was associated with reduced gastrointestinal and renal toxicity. The results indicate the combined therapy with nedaplatin to be clinically useful. (author)

  4. Translasi Pencak Silat Kedalam Film Animasi (Studi Kasus Film Kung Fu Panda

    Directory of Open Access Journals (Sweden)

    Riyo Ramadhan

    2017-09-01

    Full Text Available Sebagai tradisi yang telah membudaya dari sejak zaman dahulu kala, pencak silat lahir sebagai benteng kekuatan pertahanan diri sekaligus menjadi seni yang memperkaya khazanah kebudayaan bangsa Indonesia. Namun, kuatnya terpaan kebudayaan seni bela diri impor yang masuk (karate, kung fu, tae kwon do, muay thai, capoeira, dll, yang selalu didukung dengan berbagai kemasan media entertainment modern, membuat silat menjadi kalah populer bahkan di mata dan persepsi masyarakat Indonesia sendiri. Hal ini mengakibatkan para generasi muda memandang seni bela diri impor menjadi lebih superior ketimbang pencak silat. Jika hal ini terus berlangsung tanpa ada usaha untuk mengembangkan pencak silat melalui media modern, maka akan sangat sulit untuk mempertahankan dan mengembangkan tradisi ini di masa depan. Tujuan dari makalah ini ialah untuk membuktikan dan menggali potensi animasi sebagai media alternatif yang efektif untuk memvisualisasikan adegan dan cerita bertemakan pencak silat. Adapun studi kasus yang menjadi acuan dalam penelitian ialah film animasi “Kung Fu Panda”. Penelitian ini mengkaji studi kasus dengan menggunakan metode kualitatif deskriptif, lalu dianalisis dengan pendekatan analisis deskriptif untuk mengkaji dan mengidentifikasi pemasalahan dan solusi. Pembahasan dari makalah lebih ditekankan pada kekuatan penyampaikan cerita melalui gambar (visual storytelling yang efektif terkait dengan pencak silat. Hasil dari penelitian ialah cara penyampaian pesan yang efektif mengenai elemen dan esensi pencak silat sebagai bentuk translasinya kedalam film animasi. Pesan tersebut dapat disampaikan dengan menggunakan aspek narasi, gesture, dan simbol yang diakomodasi dengan aspek visual storytelling. Translating Pencak Silat Into An Animation Film (Case Study The Film Kung Fu Panda Abstract. A tradition that has been part of Indonesian culture since ancient times, pencak silat was born as a form of self-defense and at the same time has grown into an

  5. 5-FU resistant EMT-like pancreatic cancer cells are hypersensitive to photochemical internalization of the novel endoglin-targeting immunotoxin CD105-saporin

    OpenAIRE

    Lund, Kaja; Olsen, Cathrine Elisabeth; Wong, Judith Jing Wen; Olsen, Petter Angell; Solberg, Nina Therese; Høgset, Anders; Krauss, Stefan; Selbo, Pål Kristian

    2017-01-01

    Background Development of resistance to 5-fluorouracil (5-FU) is a major problem in treatment of various cancers including pancreatic cancer. In this study, we reveal important resistance mechanisms and photochemical strategies to overcome 5-FU resistance in pancreatic adenocarcinoma. Methods 5-FU resistant (5-FUR), epithelial-to-mesenchymal-like sub-clones of the wild type pancreatic cancer cell line Panc03.27 were previously generated in our lab. We investigated the cytotoxic effect of the ...

  6. Entwicklung einer Methode zur monetären Bewertung des Wassers für ein Unternehmen unter Einbeziehung des Wasser-Fußabdrucks

    OpenAIRE

    Hentschel, Nora

    2011-01-01

    Wassernutzung und Abbau der Frischwasser-Ressourcen sind heutzutage ein Thema, das als so wichtig wahrgenommen wird wie der Klimawandel. Wasser wird somit zunehmend Auswirkungen auf den ökonomischen Wert von Unternehmen haben. Ziel der vorliegenden Arbeit ist es, den monetären Wert des Wassers mithilfe des Wasser-Fußabdrucks zu bestimmen. Hierfür werden nach einer kurzen Einführung in Kapitel 2 der ökologische Fußabdruck, der CO2-Fußabdruck und der Wasser-Fußabdruck kurz vorgestellt und in...

  7. Optical spectroscopy of Z Canis Majoris, V1057 Cygni, and FU Orionis - Accretion disks and signatures of disk winds

    Science.gov (United States)

    Welty, Alan D.; Strom, Stephen E.; Edwards, Suzan; Kenyon, Scott J.; Hartmann, Lee W.

    1992-01-01

    High resolution, high SNR optical spectra have been used to investigate the hypothesis that in outburst, FU Ori objects are self-luminous accretion disks whose light dominates at optical and near-IR wavelengths. Strong evidence has been found for linewidth versus wavelength correlation in good agreement with model predictions for Z CMa and V1057 Cyg, but not for FU Ori itself. Linewidth varies continuously with wavelength at optical wavelengths in the former two objects, In the case of FU Ori, it is argued that a combination of strong wind components to spectral lines, and surface gravity possibly being lower than that of supergiants, conceals the underlying linewidth versus wavelength relationship. A marginal correlation is found between linewidth and lower excitation potential in all three objects. Synthetic disk spectra are subtracted from observed spectral, and remarkably good fits are found for all three objects for wavelengths longer than about 5000 A.

  8. Estudo do centro de massa e estabilidade de quatro posturas básicas do Kung-fu Pak Hok

    OpenAIRE

    Miranda,Pedro Jeferson; Brinatti,André Maurício; Silva,Silvio Luiz Rutz da; Godoy,Marino Luiz Michelin

    2016-01-01

    Este trabalho trata da análise dos centros de massa e do cálculo da estabilidade das quatro posturas básicas do Kung Fu Pak Hok. Embora a biomecânica tenha surgido em 1960, a sua aplicação em artes marciais, como no Kung Fu ainda é pouco frequente. Apesar de haver estudos de movimentos do Kung Fu, não há trabalhos sobre o centro de massa e a estabilidade para as posturas mais básicas. Este trabalho como objetivo descrever o centro de massa e a estabilidade das quatro posturas mais básicas do ...

  9. NSC30049 inhibits Chk1 pathway in 5-FU-resistant CRC bulk and stem cell populations.

    Science.gov (United States)

    Narayan, Satya; Jaiswal, Aruna S; Sharma, Ritika; Nawab, Akbar; Duckworth, Lizette Vila; Law, Brian K; Zajac-Kaye, Maria; George, Thomas J; Sharma, Jay; Sharma, Arun K; Hromas, Robert A

    2017-08-22

    The 5-fluorouracil (5-FU) treatment induces DNA damage and stalling of DNA replication forks. These stalled replication forks then collapse to form one sided double-strand breaks, leading to apoptosis. However, colorectal cancer (CRC) stem cells rapidly repair the stalled/collapsed replication forks and overcome treatment effects. Recent evidence suggests a critical role of checkpoint kinase 1 (Chk1) in preventing the replicative stress. Therefore, Chk1 kinase has been a target for developing mono or combination therapeutic agents. In the present study, we have identified a novel orphan molecule NSC30049 (NSC49L) that is effective alone, and in combination potentiates 5-FU-mediated growth inhibition of CRC heterogeneous bulk and FOLFOX-resistant cell lines in culture with minimal effect on normal colonic epithelial cells. It also inhibits the sphere forming activity of CRC stem cells, and decreases the expression levels of mRNAs of CRC stem cell marker genes. Results showed that NSC49L induces 5-FU-mediated S-phase cell cycle arrest due to increased load of DNA damage and increased γ-H2AX staining as a mechanism of cytotoxicity. The pharmacokinetic analysis showed a higher bioavailability of this compound, however, with a short plasma half-life. The drug is highly tolerated by animals with no pathological aberrations. Furthermore, NSC49L showed very potent activity in a HDTX model of CRC stem cell tumors either alone or in combination with 5-FU. Thus, NSC49L as a single agent or combined with 5-FU can be developed as a therapeutic agent by targeting the Chk1 pathway in 5-FU-resistant CRC heterogeneous bulk and CRC stem cell populations.

  10. Potentially functional SNPs (pfSNPs as novel genomic predictors of 5-FU response in metastatic colorectal cancer patients.

    Directory of Open Access Journals (Sweden)

    Jingbo Wang

    Full Text Available 5-Fluorouracil (5-FU and its pro-drug Capecitabine have been widely used in treating colorectal cancer. However, not all patients will respond to the drug, hence there is a need to develop reliable early predictive biomarkers for 5-FU response. Here, we report a novel potentially functional Single Nucleotide Polymorphism (pfSNP approach to identify SNPs that may serve as predictive biomarkers of response to 5-FU in Chinese metastatic colorectal cancer (CRC patients. 1547 pfSNPs and one variable number tandem repeat (VNTR in 139 genes in 5-FU drug (both PK and PD pathway and colorectal cancer disease pathways were examined in 2 groups of CRC patients. Shrinkage of liver metastasis measured by RECIST criteria was used as the clinical end point. Four non-responder-specific pfSNPs were found to account for 37.5% of all non-responders (P<0.0003. Five additional pfSNPs were identified from a multivariate model (AUC under ROC = 0.875 that was applied for all other pfSNPs, excluding the non-responder-specific pfSNPs. These pfSNPs, which can differentiate the other non-responders from responders, mainly reside in tumor suppressor genes or genes implicated in colorectal cancer risk. Hence, a total of 9 novel SNPs with potential functional significance may be able to distinguish non-responders from responders to 5-FU. These pfSNPs may be useful biomarkers for predicting response to 5-FU.

  11. Chemoresistance to 5-FU inhibited by 635 nm LED irradiation in CD133+ KB cell line.

    Science.gov (United States)

    Kim, Donghwi; Park, Mineon; Jang, Hyunwoong; Hyun, Hoon; Lim, Wonbong

    2018-01-01

    Consistent with cancer stem cell theory, a small fraction of cancer cells, described as cancer stem cells (CSCs), may promote tumor recurrence and anti-cancer drug resistance. Therefore, much effort has been devoted to the development of CSC targeted therapy to vanquish drug resistance. In this study, we have investigated the effect of multiple light-emitting diode (LED) irradiation treatments with conventional anti-cancer drugs on CSC-like oral cancer cells that acquired stemness by ectopic over expression of CD133. To evaluate combined LED irradiation anti-cancer drug effects, we investigated the chemosensitizing effect of 635 nm irradiation on 5-fluorouracil (5FU)-treated KB CD133+ and KB Vec cells, interrogating the underlying molecular mechanisms associated with stemness and apoptosis that are responsible for chemopreventive activity. In addition, combination therapy with LED irradiation and 5-FU treatment was carried out in KB CD133+ and KB Vec cell-inoculated mouse models. LED irradiation of 635 nm inhibited CSC-like properties consistent with a decrease in OCT4 and NANOG protein expression, reducing colony-forming ability. In addition, LED irradiation enhanced 5-FU-induced cytotoxicity and improved 5-FU chemosensitivity in KB CD133+ via enhancement of apoptosis. These findings were validated in vivo, wherein LED irradiation combined with 5-FU treatment inhibited tumor growth in KB CD133+ -inoculated mice. Collectively, our results provide novel evidence for 635 nm irradiation-induced 5-FU chemosensitization of CSC in oral cancer. In addition, this research highlights that 635 nm LED irradiation may serve as an adjunct treatment to conventional chemotherapeutic drugs in patients with oral cancer.

  12. High response rates following paclitaxel/5-FU and simultaneous radiotherapy in advanced head and neck carcinoma; Hohe Remissionsraten unter simultaner Radio- und Chemotherapie mit Paclitaxel/5-FU in der Behandlung fortgeschrittener Kopf-Hals-Tumoren

    Energy Technology Data Exchange (ETDEWEB)

    Schroeder, M.; Westerhausen, M. [St.-Johannes-Hospital, Duisburg (Germany). Medizinische Klinik II; Makoski, H.B. [Staedtische Kliniken, Duisburg (Germany). Radioonkologie; Sesterhenn, K. [St. Anna-Krankenhaus, Duisburg (Germany). HNO-Klinik; Schroeder, R. [Bristol Myers Squibb, Muenchen (Germany). Dept. of Oncology

    1997-11-01

    The main stay of treatment for head and neck cancer patients with advanced disease has been chemotherapy with Cisplatin/5-FU and simultaneous applied radiotherapy. With this multimodality treatment including radical surgery after two cycles of neoadjuvant chemotherapy and 40 Gy radiotherapy we reported 60% complete remission after 5 years for patients with stage III/IV of head and neck cancer. Paclitaxel, a new plant product, has demonstrated significant antineoplastic activity in head and neck tumors (ECOG-Study: 40% RR). Therefore we performed a trial with Taxol/5-FU and simultaneous radiation in a neoadjuvant and postoperative adjuvant setting of stage III/IV squamous cell carcinoma of the head and neck with pre-existent contraindication against Cisplatin. Patients and Methods: 30 patients with a primarily inoperable stage III/IV of SCC of the head and neck were enrolled to receive day 1 and 29 Taxol 175 mg/m{sup 2} as a 3-hour-infusion, followed by 120-hour-cvi of 1000 mg/m{sup 2}/d 5-FU. Locally irradiation was given ad 40 Gy (2 Gy/d/day 1-26). Radical surgery followed about day 56. Postoperatively patients received again 2 cycles of Taxol/5-FU and simultaneous irradiation with 30 Gy. Results: So far 30 patients were treated and all patients reached a CR after complete treatment, ongoing for 23/30 patients for 6 till 34 months: 4 patients developed a second neoplasia, and 3 patients gloved a local relapse. The principal toxicity was moderate (neutropenia, peripheral neuropathy, arthralgia/myalgia) and sensible with supportive care (e.g. PEG). Conclusions: The results suggest that the treatment of SCC of the head and neck with Taxol/5-FU and simultaneous radiation and radical surgery is a highly effective schedule and comparable with the treatment with Cisplatin/5-FU. (orig.) [Deutsch] Der Standard in der Behandlung weit forgeschrittener, primaer inoperabler Kopf-Hals-Tumoren stellte die Cisplatinhaltige Chemotherapiekombination mit 5-FU dar mit simultan

  13. Clinical research on disciplinarian and character of treatment of zang-fu in syndrome differentiation on insomnia

    Institute of Scientific and Technical Information of China (English)

    凌丽; 薛金伟; 东贵荣

    2005-01-01

    Objective To investigate the therapeutic effect of insomnia with zang-fu in syndrome differentiation. Methods Seventy patients with insomnia according to the diagnostic sequence were randomly divided into two groups, the treatment group and the control group. Two groups received the therapeutic methods of acupuncture in syndrome differentiation and general acupuncture separately. After two courses of treatment and one month's follow-up, therapeutic effect was evaluated through statistical analysis. Resulds The therapeutic effects of the treatment group and the control group have significant differences which have statistical significance. Conclusion Zang-fu in syndrome differentiation may enhance the clinical therapeutic effect of insomnia.

  14. Comparison of force, power, and striking efficiency for a Kung Fu strike performed by novice and experienced practitioners: preliminary analysis.

    Science.gov (United States)

    Neto, Osmar Pinto; Magini, Marcio; Saba, Marcelo M F; Pacheco, Marcos Tadeu Tavares

    2008-02-01

    This paper presents a comparison of force, power, and efficiency values calculated from Kung Fu Yau-Man palm strikes, when performed by 7 experienced and 6 novice men. They performed 5 palm strikes to a freestanding basketball, recorded by high-speed camera at 1000 Hz. Nonparametric comparisons and correlations showed experienced practitioners presented larger values of mean muscle force, mean impact force, mean muscle power, mean impact power, and mean striking efficiency, as is noted in evidence obtained for other martial arts. Also, an interesting result was that for experienced Kung Fu practitioners, muscle power was linearly correlated with impact power (p = .98) but not for the novice practitioners (p = .46).

  15. Overcoming acquired drug resistance in colorectal cancer cells by targeted delivery of 5-FU with EGF grafted hollow mesoporous silica nanoparticles

    Science.gov (United States)

    Chen, Lijue; She, Xiaodong; Wang, Tao; He, Li; Shigdar, Sarah; Duan, Wei; Kong, Lingxue

    2015-08-01

    Acquired drug resistance (ADR) can be developed in colorectal cancer cells after 5-fluorouracil (5-FU) treatment and diminish the effectiveness of chemotherapy. In this work, acquired 5-FU resistance in the colorectal cancer cell line SW480 was obtained with the up-regulation of dihydropyrimidine dehydrogenase (DPYD) gene expression which can convert 5-FU to its inactive metabolite. To overcome ADR in colorectal cancer, hollow mesoporous silica nanoparticles (HMSNs) grafted with epidermal growth factor (EGF) were used as nanocarriers to deliver 5-FU to colorectal cancer cells with acquired drug resistance. The effect and mechanism of 5-FU loaded EGF grafted HMSNs (EGF-HMSNs-5-FU) in overcoming acquired drug resistance in SW480/ADR cells were studied. The EGF-HMSNs were demonstrated to be specifically internalized in EGFR overexpressed SW480/ADR cells via a receptor-mediated endocytosis and can escape from endo-lysosomes. The EGF-HMSNs-5-FU exhibited much higher cytotoxicity on SW480/ADR cells than HMSNs-5-FU and free 5-FU while the plain HMSNs did not show significant cytotoxicity. The mechanism of EGF-HMSNs-5-FU in overcoming drug resistance in SW480/ADR cells could be attributed to the specific internalization of EGF-HMSNs-5-FU in EGFR overexpressed cells which can lead to high intracellular drug accumulation and cause cell death through S phase arrest.Acquired drug resistance (ADR) can be developed in colorectal cancer cells after 5-fluorouracil (5-FU) treatment and diminish the effectiveness of chemotherapy. In this work, acquired 5-FU resistance in the colorectal cancer cell line SW480 was obtained with the up-regulation of dihydropyrimidine dehydrogenase (DPYD) gene expression which can convert 5-FU to its inactive metabolite. To overcome ADR in colorectal cancer, hollow mesoporous silica nanoparticles (HMSNs) grafted with epidermal growth factor (EGF) were used as nanocarriers to deliver 5-FU to colorectal cancer cells with acquired drug resistance. The

  16. The Protective Effects of Shen-Fu Injection on Experimental Acute Pancreatitis in a Rat Model

    Directory of Open Access Journals (Sweden)

    Lei Huang

    2014-01-01

    Full Text Available Objectives. In the present study, we investigated the protective effects of Shen-Fu injection (SFI on a caerulein-induced rat pancreatitis (AP model. Methods. SFI was given to rats in the SFI treated group through intraperitoneal injection. Blood and pancreas samples were collected for serological and histopathological studies. Results. Our results showed that AP caused significant decrease in tissue glutathione (GSH and serum IL-4 and IL-10, while pancreatic malondialdehyde (MDA and myeloperoxidase (MPO were increased. Furthermore, TNF-α, IL-1β, amylase, and lipase levels were also significantly increased. On the other hand, SFI treatment reserved all these biochemical indices as well as histopathologic alterations that were induced by caerulein. Conclusion. Our findings suggest that the SFI protects against caerulein-induced AP in rats via modulation of cytokines, oxidative stress, and Nuclear Factor-kappa B (NF-κB activity.

  17. DISENTANGLING THE ENVIRONMENT OF THE FU ORIONIS CANDIDATE HBC 722 WITH HERSCHEL

    International Nuclear Information System (INIS)

    Green, Joel D.; Evans, Neal J. II; Merello, Manuel; Pooley, David; Kospal, Agnes; Van Kempen, Tim A.; Van Dishoeck, Ewine; Herczeg, Gregory; Quanz, Sascha P.; Henning, Thomas; Bouwman, Jeroen; Lee, Jeong-Eun; Dunham, Michael M.; Meeus, Gwendolyn; Chen, Jo-Hsin; Guedel, Manuel; Skinner, Stephen L.; Rebull, Luisa M.; Guieu, Sylvain

    2011-01-01

    We analyze the submillimeter emission surrounding the new FU Orionis-type object, HBC 722. We present the first epoch of observations of the active environs of HBC 722, with imaging and spectroscopy from PACS, SPIRE, and HIFI on board the Herschel Space Observatory, as well as CO J = 2-1 and 350 μm imaging (SHARC-II) with the Caltech Submillimeter Observatory. The primary source of submillimeter continuum emission in the region-2MASS 20581767+4353310-is located 16'' south-southeast of the optical flaring source while the optical and near-infrared emission is dominated by HBC 722. A bipolar outflow extends over HBC 722; the most likely driver is the submillimeter source. We detect warm (100 K) and hot (246 K) CO emission in the surrounding region, evidence of outflow-driven heating in the vicinity. The region around HBC 722 itself shows little evidence of heating driven by the new outbursting source itself.

  18. [XI Hong, XI Hong acupuncture school of thought and Xi Hong Fu].

    Science.gov (United States)

    Xu, Chun-Juan; Chen, Rong; Yang, Yong-Shou

    2008-11-01

    XI Hong, a famous acupuncturist in the Southern Song Dynasty, has an important influence and status in history of Chinese acupuncture and moxibustion. After he moved to Linchuan, Jiangxi province, his descendants passed acupuncture from generation to generation. According to records, it was passed to 12 generations. After the tenth generation, it was also passed to apprentices besides descendants, such as accomplished acupuncturists CHEN Hong-gang, LIU Jin and others, forming XI Hong acupuncture school of thought. The poem of acupuncture and moxibustion XI Hong Fu is the representative work about XI Hong academic thought, which was additionally compiled or written by XI Hong's apprentices according to XI Hong academic thought. The poems are of characteristics in acupuncture application and association of acupoints. The academic thought and therapeutic methods of acupuncture in the poems still are widely used in modern clinical acupuncture practice.

  19. Mass loss from pre-main-sequence accretion disks. I - The accelerating wind of FU Orionis

    Science.gov (United States)

    Calvet, Nuria; Hartmann, Lee; Kenyon, Scott J.

    1993-01-01

    We present evidence that the wind of the pre-main-sequence object FU Orionis arises from the surface of the luminous accretion disk. A disk wind model calculated assuming radiative equilibrium explains the differential behavior of the observed asymmetric absorption-line profiles. The model predicts that strong lines should be asymmetric and blueshifted, while weak lines should be symmetric and double-peaked due to disk rotation, in agreement with observations. We propose that many blueshifted 'shell' absorption features are not produced in a true shell of material, but rather form in a differentially expanding wind that is rapidly rotating. The inference of rapid rotation supports the proposal that pre-main-sequence disk winds are rotationally driven.

  20. From specific training to global shift of manual preference in Kung Fu experts.

    Science.gov (United States)

    Maeda, Rodrigo S; Souza, Rosana M; Teixeira, Luis A

    2014-02-01

    Manual preference and intermanual performance asymmetry have been approached from a multidimensional and dynamic perspective. A point of interest from that approach is the role of lateralized motor experiences on handedness. In this study, intermanual performance asymmetry in sport-specific movements and manual preference in daily living tasks were compared between Kung Fu athletes and novices. Analysis of movement time in the performance of interlaterally symmetric and asymmetric movement patterns showed smaller intermanual performance asymmetry in experts. Analysis of manual preference using the Edinburgh Handedness Inventory indicated that experts presented predominantly weak or moderate strength of right hand preference. Novices, conversely, were found to have predominantly strong right hand preference. These results suggest that extensive bimanual training by experts leads to a global shift of manual preference, affecting hand selection in distinct tasks.

  1. Cold CO Gas in the Envelopes of FU Orionis-type Young Eruptive Stars

    Energy Technology Data Exchange (ETDEWEB)

    Kóspál, Á.; Ábrahám, P.; Moór, A. [Konkoly Observatory, Research Centre for Astronomy and Earth Sciences, Hungarian Academy of Sciences, Konkoly-Thege Miklós út 15-17, 1121 Budapest (Hungary); Csengeri, T.; Güsten, R. [Max-Planck-Institut für Radioastronomie, Auf dem Hügel 69, D-53121 Bonn (Germany); Henning, Th. [Max-Planck-Institut für Astronomie, Königstuhl 17, D-69117 Heidelberg (Germany)

    2017-02-20

    FU Orionis-type objects (FUors) are young stellar objects experiencing large optical outbursts due to highly enhanced accretion from the circumstellar disk onto the star. FUors are often surrounded by massive envelopes, which play a significant role in the outburst mechanism. Conversely, the subsequent eruptions might gradually clear up the obscuring envelope material and drive the protostar on its way to become a disk-only T Tauri star. Here we present an APEX {sup 12}CO and {sup 13}CO survey of eight southern and equatorial FUors. We measure the mass of the gaseous material surrounding our targets, locate the source of the CO emission, and derive physical parameters for the envelopes and outflows, where detected. Our results support the evolutionary scenario where FUors represent a transition phase from envelope-surrounded protostars to classical T Tauri stars.

  2. Clinical evaluation of adjuvant chemoradiotherapy with CDDP, 5-Fu, and VP-16 for advanced esophageal cancer

    Energy Technology Data Exchange (ETDEWEB)

    Mukaida, Hidenori; Hirai, Toshihiro; Yamashita, Yoshinori; Yoshida, Kazuhiro; Hihara, Jun; Kuwahara, Masaki; Inoue, Hideki; Toge, Tetsuya [Hiroshima Univ. (Japan). Research Inst. for Radiation Biology and Medicine

    1998-01-01

    The aim of this study was to evaluate the efficacy of adjuvant chemoradiotherapy following surgery in patients with advanced esophageal cancer. We followed the cases of 57 such patients treated at our hospital, involving 19 who received adjuvant chemoradiotherapy (CR group), 19 who received radiotherapy alone (R group), and 19 who did received neither (N group). In the CR group, chemotherapy, consisting of cis-diaminodichloroplatinum (CDDP), 5-fluorouracil (5-FU), and etoposide (VP-16), was combined with radiotherapy was administered from 4 weeks after surgery. Concurrent radiotherapy was started at 3 weeks after esophagectomy. CDDP at 50 mg/m{sup 2} was administered on days 1 and 7.5-FU at 500 mg/m{sup 2} and VP-16 at 60 mg/m{sup 2} were administered on days 3, 4, and 5. Thirteen patients (68.4%) were treated with more than 2 cycles of chemotherapy combined with radiation. Side-effects of severe anorexia (grade 3) and leukocytopenia (<1900/{mu}l) were observed in 47% and 39% of the patients, respectively. However no treatment-related death was observed. The 5-year-survival rate was 25.2%, 18.9%, and 15.8%, in the CR group, R group, and N group, respectively. The recurrence rate was 66.7% in the CR group, which was higher than in the matched control groups (46.2% in the N group and 54.5% in the R group), but with no significant difference. These results suggested that adjuvant chemoradiotherapy did not contribute to improvement in prognosis for these patients with advanced esophageal cancer. (author)

  3. Clinical evaluation of adjuvant chemoradiotherapy with CDDP, 5-Fu, and VP-16 for advanced esophageal cancer

    International Nuclear Information System (INIS)

    Mukaida, Hidenori; Hirai, Toshihiro; Yamashita, Yoshinori; Yoshida, Kazuhiro; Hihara, Jun; Kuwahara, Masaki; Inoue, Hideki; Toge, Tetsuya

    1998-01-01

    The aim of this study was to evaluate the efficacy of adjuvant chemoradiotherapy following surgery in patients with advanced esophageal cancer. We followed the cases of 57 such patients treated at our hospital, involving 19 who received adjuvant chemoradiotherapy (CR group), 19 who received radiotherapy alone (R group), and 19 who did received neither (N group). In the CR group, chemotherapy, consisting of cis-diaminodichloroplatinum (CDDP), 5-fluorouracil (5-FU), and etoposide (VP-16), was combined with radiotherapy was administered from 4 weeks after surgery. Concurrent radiotherapy was started at 3 weeks after esophagectomy. CDDP at 50 mg/m 2 was administered on days 1 and 7.5-FU at 500 mg/m 2 and VP-16 at 60 mg/m 2 were administered on days 3, 4, and 5. Thirteen patients (68.4%) were treated with more than 2 cycles of chemotherapy combined with radiation. Side-effects of severe anorexia (grade 3) and leukocytopenia (<1900/μl) were observed in 47% and 39% of the patients, respectively. However no treatment-related death was observed. The 5-year-survival rate was 25.2%, 18.9%, and 15.8%, in the CR group, R group, and N group, respectively. The recurrence rate was 66.7% in the CR group, which was higher than in the matched control groups (46.2% in the N group and 54.5% in the R group), but with no significant difference. These results suggested that adjuvant chemoradiotherapy did not contribute to improvement in prognosis for these patients with advanced esophageal cancer. (author)

  4. Potential emerging treatment in vitiligo using Er:YAG in combination with 5FU and clobetasol.

    Science.gov (United States)

    Mokhtari, Fatemeh; Bostakian, Anis; Shahmoradi, Zabihollah; Jafari-Koshki, Tohid; Iraji, Fariba; Faghihi, Gita; Hosseini, Sayed Mohsen; Bafandeh, Behzad

    2018-04-01

    Vitiligo is a pigmentary disorder of skin affecting at least 1% of the world population of all races in both sexes. Its importance is mainly due to subsequent social and psychological problems rather than clinical complications. Various treatment choices are available for vitiligo; however, laser-based courses have shown to give more acceptable results. The aim of this trial was to evaluate the efficacy of Er:YAG laser as a supplementary medicine to topical 5FU and clobetasol in vitiligo patients. Two comparable vitiligo patches from 38 eligible patients were randomized to receive topical 5FU and clobetasol in control group and additional Er:YAG laser in intervention group. Major outcomes of interest were the size of patch and pigmentation score at randomization and 2 and 4 months after therapy. Final sample included 18 (47%) male patients and age of 35.66±8.04. The performance Er:YAG group was superior in all sites. Reduction in the size of patches was greater in Er:YAG group (p-value=.004). Also, this group showed a higher pigmentation scores in the trial period than control group (p-value<.001). Greater reduction in the size and increase in pigmentation score was seen in Er:YAG group especially for short periods after therapy and repeating laser sessions may help improving final outcomes. Er:AYG could help in reducing complications of long-term topical treatments, achieving faster response, and improving patient adherence. © 2017 Wiley Periodicals, Inc.

  5. Fuels planning: science synthesis and integration; environmental consequences fact sheet 12: Water Erosion Prediction Project (WEPP) Fuel Management (FuMe) tool

    Science.gov (United States)

    William Elliot; David Hall

    2005-01-01

    The Water Erosion Prediction Project (WEPP) Fuel Management (FuMe) tool was developed to estimate sediment generated by fuel management activities. WEPP FuMe estimates sediment generated for 12 fuel-related conditions from a single input. This fact sheet identifies the intended users and uses, required inputs, what the model does, and tells the user how to obtain the...

  6. CCHMM_PROF: a HMM-based coiled-coil predictor with evolutionary information

    DEFF Research Database (Denmark)

    Bartoli, Lisa; Fariselli, Piero; Krogh, Anders

    2009-01-01

    tools are available for predicting coiled-coil domains in protein sequences, including those based on position-specific score matrices and machine learning methods. RESULTS: In this article, we introduce a hidden Markov model (CCHMM_PROF) that exploits the information contained in multiple sequence...... alignments (profiles) to predict coiled-coil regions. The new method discriminates coiled-coil sequences with an accuracy of 97% and achieves a true positive rate of 79% with only 1% of false positives. Furthermore, when predicting the location of coiled-coil segments in protein sequences, the method reaches...

  7. Ethical and cultural value of the Earth sciences. Interview with Prof. Giulio Giorello

    Directory of Open Access Journals (Sweden)

    Silvia Peppoloni

    2012-07-01

    Full Text Available Prof. Giulio Giorello is amongst the most prominent philosophers of science in Italy and in the world. He is currently Professor of the Philosophy of Science at the University of Milan, Director of the Series ‘Science and Ideas’ (Raffaele Cortina Books Editor, and Literary Journalist of the cultural pages of the Corriere della Sera, one of the most important of the Italian newspapers. In this keynote presentation, in interview form, he talks about the value that the Earth sciences have had through history, framing this group of disciplines in ethical and epistemological terms, and highlighting some important elements that have to be considered in geological activities.

  8. Prof. dr Zvonimir Dévidé (prigodom 65. godišnjice života)

    OpenAIRE

    Papeš, Dražena; Jelaska, Sibila

    1986-01-01

    Zvonimir Dévidé, Ph. D. habil., Professor of cell biology and plant physiology at the Faculty of Natural Sciences and Mathematics of the University of Zagreb, was born on 6.8.1921 in Lenart, Slovenske Gorice (North-eastern Slovenia). Having completed his studies at the Philosophical Faculty in Zagreb and in Vienna (where his academic advisor was prof. dr. Lothar Geitler) he started to work in 1948 as asistant in the Botanic Institute of the Faculty of Natural Sciences and Mathematics of the U...

  9. The 'Prof. Dr. Rómulo Lambre' Collection: an Argentinian sample of modern skeletons.

    Science.gov (United States)

    Salceda, S A; Desántolo, B; Mancuso, R García; Plischuk, M; Inda, A M

    2012-08-01

    This paper describes the 'Prof. Dr. Rómulo Lambre' skeletal collection. The Lambre Collection is housed in the School of Medical Sciences of the National University of La Plata and it consists of skeletal remains ceded by the Municipal Cemetery of La Plata. The collection has more than four hundred skeletons, with information on age, sex, nationality, date and cause of death. It was created for teaching and research purposes in compliance with current legislation, and its management meets guidelines specified in the Declaration of the Argentinian Association for Biological Anthropology on Research Ethics on Human Remains (2007). Copyright © 2012 Elsevier GmbH. All rights reserved.

  10. [Very late but too early... prof. Angelo Chiavaro and the Italian degree in dentistry].

    Science.gov (United States)

    Eramo, Stefano; Bensi, Caterina; Belli, Stefano; Pagano, Stefano

    2017-12-01

    The birth of the Degree in Dentistry in Italy has been very troubled, and only in 1980 saw its effective implementation. Very "instructive" in this regard is the history on the establishment in 1924 (the period of the seizure of power by Fascism) of a "National School of Dentistry" at the University of Rome, which was withdrawn after only ten months. The biggest supporter and proponent of the School, Prof. Angelo Chiavaro, after a few years, was "punished" with the transfer from the University of Rome to that of Genoa. We present some brief notes on the biography of this courageous pioneer and the matter of which he was the protagonist.

  11. Prof. Dr. C. J. H. De Wet. (’n Persoonlike waardering.

    Directory of Open Access Journals (Sweden)

    J. C. Coetzee

    1959-03-01

    Full Text Available Ek het prof. De Wet vir eerste maal ontmoet toe hy aan die begin van1912 student geword het aan die Teologiese Skool van die Gereformeerde Kerkop Potchefstroom. Ek was toe student aan dieselfde inrigting en in my laastejaar vir die graad B.A. Hy was onder ons studente bekend as 'n hardwerkend een baie begaafde jongman. In ons studenteverenigings en -samenkomste het hy hom openbaar -as iemand met ’n breedheid van insig en ’n helderheid van formulering wat kenmerkend gedurende sy hele latere optrede sou wees.

  12. The role of effective mass and hand speed in the performance of kung fu athletes compared with nonpractitioners.

    Science.gov (United States)

    Neto, Osmar Pinto; Magini, Marcio; Saba, Marcelo M F

    2007-05-01

    The main goal of this article is to quantify the contribution of effective mass (me) and handspeed (shi) on the palm strike performance of kung fu athletes (kung fu group) compared with nonpractitioners (control group). All subjects were asked to strike a basketball. Hand and ball speed (sbf) were determined by high-speed video analysis. The value for me was determined by an equation that does not depend upon postimpact measurement of the hand speed. The results show that kung fu athletes had greater shi (6.67 [SD 1.42] m/s), p = 0.042), higher me (2.62 [SD 0.33] kg, p = 0.004), and greater sbf (9.00 [SD 1.89] m/s), p = 0.004) than the nonpractitioners (5.04 [SD 0.57] m/s, 1.33 [SD 0.19] kg, and 5.72 [SD 0.44] m/s, respectively). Comparing the average values obtained for me and hand and forearm mass (m), it was found that for the control group me is statistically equal to m (p = 0.917), whereas for the kung fu group me is significant greater than m (p = 0.003). It is suggested that for impacts against heavier objects, the effective mass would be the main factor to distinguish a martial arts-trained from an untrained subject.

  13. The Effect of 5 FU on the Expression of Transforming Growth Factor Beta-1 (Tgf-1 in Cultured Tendon Cells

    Directory of Open Access Journals (Sweden)

    Zeynep Karacor Altuntas

    2014-10-01

    Full Text Available This study investigated the effect of the treatment with 1 min exposures to 5-fluorouracil (5-FU  on the expression of TGF-beta 1 in cultured tendon cells. Fibroblasts cultured from the flexor tendons of dog paws were treated with 3 different doses of 5-FU ( control, 5-15-25 mgr /ml for 1 minute.  After 5-FU exposure  the expression of TGF –beta 1 were tested by real time Reverse Transcriptase-Polymerase Chain Reaction (RT-PCR at 3rd and 7th days. There were no statistically significant differences in the expression levels of the TGF-b1 gene between the control group and all other groups on day 3 and 7 (p>0.05.However, when the percentage changes in the TGF-BETA1 gene expression on days 3–7 were compared, there were statistically significant differences and this was maximally observed with 89% +12 (p<0.05 in the group treated with 25-mg/ml 5-FU.  We conclude that 1min. 5-FU application may be  sufficient to prevent adhesions in tendon healing by limiting the expression of TGF-BETA1. 

  14. The effect on the small bowel of 5-FU and oxaliplatin in combination with radiation using a microcolony survival assay

    Directory of Open Access Journals (Sweden)

    Kjellén Elisabeth

    2009-12-01

    Full Text Available Abstract Background In locally advanced rectal cancer, 5-Fluorouracil (5-FU-based chemoradiation is the standard treatment. The main acute toxicity of this treatment is enteritis. Due to its potential radiosensitizing properties, oxaliplatin has recently been incorporated in many clinical chemoradiation protocols. The aim of this study was to investigate to what extent 5-FU and oxaliplatin influence the radiation (RT induced small bowel mucosal damage when given in conjunction with single or split dose RT. Methods Immune competent balb-c mice were treated with varying doses of 5-FU, oxaliplatin (given intraperitoneally and total body RT, alone or in different combinations in a series of experiments. The small bowel damage was studied by a microcolony survival assay. The treatment effect was evaluated using the inverse of the slope (D0 of the exponential part of the dose-response curve. Results In two separate experiments the dose-response relations were determined for single doses of RT alone, yielding D0 values of 2.79 Gy (95% CI: 2.65 - 2.95 and 2.98 Gy (2.66 - 3.39, for doses in the intervals of 5-17 Gy and 5-10 Gy, respectively. Equitoxic low doses (IC5 of the two drugs in combination with RT caused a decrease in jejunal crypt count with significantly lower D0: 2.30 Gy (2.10 - 2.56 for RT+5-FU and 2.27 Gy (2.08 - 2.49 for RT+oxaliplatin. Adding both drugs to RT did not further decrease D0: 2.28 Gy (1.97 - 2.71 for RT+5-FU+oxaliplatin. A clearly higher crypt survival was noted for split course radiation (3 × 2.5 Gy compared to a single fraction of 7.5 Gy. The same difference was seen when 5-FU and/or oxaliplatin were added. Conclusion Combining 5-FU or oxaliplatin with RT lead to an increase in mucosal damage as compared to RT alone in our experimental setting. No additional reduction of jejunal crypt counts was noted when both drugs were combined with single dose RT. The higher crypt survival with split dose radiation indicates a

  15. Loss of ABCB4 attenuates the caspase-dependent apoptosis regulating resistance to 5-Fu in colorectal cancer.

    Science.gov (United States)

    Hu, Hanqing; Wang, Meng; Guan, Xu; Yuan, Ziming; Liu, Zheng; Zou, Chaoxia; Wang, Guiyu; Gao, Xu; Wang, Xishan

    2018-02-28

    The adenosine triphosphate-binding cassette (ABC) is a large group of proteins involved in material transportation, cellular homeostasis, and closely associated with chemoresistance. ATP-binding cassette protein B4 (ABCB4) is a member of ABCs which has a similar structure to ABCB1, but fewer researches were performed. The present study is aimed to investigate the putative mechanism of ABCB4 in 5-fluorouracil (5-Fu) resistance. Then, we found that ABCB4 was significantly down-regulated in the 5-Fu resistant HCT8 cell lines by polymerase chain reaction (PCR) and Western blot. The knockdown of ABCB4 by small interfering RNA decreased the apoptosis by 5-Fu in resistant HCT8R cell lines without influencing the proliferation. Also, we found a lower expression of cleaved caspase and PARP by Western blot after the knockdown of ABCB4. However, the knockdown of ABCB4 did not influence the proliferation and apoptosis. Furthermore, the histological detection of ABCB4 mRNA level in human colorectal cancer tissues and even in the recurrent tissues after 5-Fu single-agent chemotherapy was employed to provide more concrete evidence that ABCB4 may be a tumor suppressor gene to regulate chemoresistance in colorectal cancer. Moreover, a 109-patient cohort revealed that ABCB4 predicted a poor recurrence-free survival and overall survival. In summary, ABCB4 was down-regulated in the 5-Fu resistant cells and knockdown of ABCB4 alleviated the cell apoptosis and predicts a shorter recurrence-free survival and overall survival. © 2018 The Author(s).

  16. Low Impact Development Intensive Rural Construction Planning in Xu Fu Village Ningbo, China: Planning Review through Rural Resilience Perspective

    Directory of Open Access Journals (Sweden)

    Roosmayri Lovina Hermaputi

    2017-08-01

    Full Text Available Xu Fu Village Ningbo LID Intensive Rural Construction Planning is a cooperation project between Zhejiang University and Ningbo Institute of Technology which named "12th Five-Year National Science and Technology support program-the comprehensive demonstration of the key technology of the beautiful rural construction in the rapid urbanization area of the Yangtze River Delta". This plan focuses on intensive rural construction as part of rural development and construction project that applies the principles of low impact development. Xu Fu Village located in the Yangtze River Delta Region. Currently, the rural growth brings the high impact of development, as a result of rapid urbanization growth arising several issues, such as low land use efficiency, dispersed rural residence, homestead occupies more, rural roads covering over, etc. Meanwhile, Xu Fu village wishes to develop its tourism potential. Thus, the intensive rural construction should be done to avoid the severe effect. The project result hopefully can improve the quality and level of rural residential planning, design, and construction; improve their living environment; save construction land and water use; and improve energy efficiency. The aim of this study is to review the Low Impact Development (LID Intensive Rural Construction in Xu Fu Village, Ningbo City through the rural resilience perspective. This paper will describe the project plan first, then review it through rural resilience perspective. This paper will elaborate the rural resilience theory and then review the rural resiliency through two parts; the first part is identifying rural resilience in rural infrastructure development based on the criteria created by Ayyob S. and Yoshiki Y. (2014, about urban resiliency criteria, and then the second part is reviewing Xu Fu Village resilience through Arup Resilience Qualities (2012, considering three rural resilience domain (economy, ecology, and cultural.

  17. In vivo 19F-MRS observation of 5-FU metabolism in fatty liver induced by choline-deficient diet

    International Nuclear Information System (INIS)

    Otsuka, Hideki; Harada, Masafumi; Nishitani, Hiromu; Koga, Keiko.

    1996-01-01

    Using 19 F-MRS, 5-FU metabolism was investigated in rat fatty liver. Fatty liver was induced by choline-deficient diet (CD diet). This study showed differences in 5-FU metabolism between normal and fatty liver. After laparotomy, a surface coil was placed directly on the liver surface. Spectra were continuously obtained after injection of 5-FU 100 mg/kg body weight via a catheter inserted into femoral vein. We made MRI and 1 H-MRS study to examine the lipid accumulation. Histological study was also performed using HE (hematoxylin-eosin) and oil red stain. The livers of rats fed a CD diet showed very high intensity on T 1 -WI. 1 H-MRS was very useful in deteminating the fat content because the fat ratio demonstrated by 1 H-MRS is well correlated to histological findings. In 19 F-MRS, we recognized the following four peaks: 5-FU, FBAL, Fnct (fluoronucleotide) and FUPA. The decrease of 5-FU was not very apparent, but compared to the normal liver, the formation of Fnct increased and the formation of FBAL was suppressed in fatty liver. The rats fed a CD diet for four weeks showed a higher Fnct peak and lower FBAL peak compared with the results of rats fed a CD diet for two weeks. In a CD diet group, liver cell degeneration and necrotic changes were observed histologically. It is reported that cell degeneration is followed by cell proliferation in fatty liver induced by a choline deficient diet, and the high Fnct peak found in our study may reflect this phenomenon. The high Fnct peak on 19 F-MRS may correspond to recovering reaction from liver injury like fatty liver. (author)

  18. Everybody was Kung-Fu fighting-The beneficial effects of Tai Chi Qigong and self-defense Kung-Fu training on psychological and endocrine health in middle aged and older men.

    Science.gov (United States)

    Walther, A; Lacker, T J; Ehlert, U

    2018-02-01

    Higher age is associated to a variety of physical and mental disorders. Age-related changes in steroid secretion have been suggested to be an underlying mechanism leading to frailty, depression, and sexual dysfunction. However, Tai chi qigong and similar forms of exercise have been shown to improve a great variety of health-related parameters in older individuals. We examined 56 self-reporting healthy men actively practicing Tai chi qigong and/or self-defense Kung-fu and 55 age-matched self-reporting healthy controls. Saliva samples were obtained in a standardized procedure for subsequent quantification of circulating testosterone and cortisol levels. In addition, depressive symptoms, life satisfaction, and sexual health were assessesd via self-report questionnaires. Age was negatively associated with testosterone, while no association emerged for cortisol. Tai chi qigong and/or self-defense Kung-fu training was neither associated with testosterone nor cortisol. More weekly Tai chi qigong and/or self-defense Kung-fu training (4 or more times per week) was instead associated with a lower CT-ratio, less depressive symptoms, and higher life satisfaction compared to individuals, who trained only one to three times per week. More years of Tai chi qigong and/or self-defense Kung-fu training were associated with less depressive symptoms and higher life satisfaction but not with the CT-ratio. No significant associations emerged for Tai chi qigong and/or self-defense Kung-fu training and sexual health. When compared to the age-matched controls, there is a significant effect of Tai chi, qigong and/or self-defense Kung-fu on the CT-ratio. Contrast analyses revealed a significantly lower CT-ratio for the high training load group in contrast to the low training load group. Further, in contrast to the control group, the low training load group exhibits a significantly higher CT-ratio. For depression, contrast analyses revealed a significantly lower level of depression in the

  19. Rezension von: Ulf Gebken, Söhnke Vosgerau (Hg.: Fußball ohne Abseits. Ergebnisse und Perspektiven des Projekts ‚Soziale Integration von Mädchen durch Fußball‘. Wiesbaden: Springer VS 2014.

    Directory of Open Access Journals (Sweden)

    Robert Claus

    2014-12-01

    Full Text Available Seit 2006 wurden im Rahmen des vom Deutschen Fußball-Bund durchgeführten Modellprojektes „Soziale Integration von Mädchen durch Fußball“ an über 200 Standorten Schul-AGs in sogenannten Brennpunktbezirken aufgebaut. Im vorliegenden Sammelband beleuchten die Autor/-innen ausführlich die Funktion von Sport für die pädagogische Kompetenzvermittlung. Zudem erbringen sie einen umfassenden Projektbericht und leisten ein Plädoyer für die Modernisierung des Verhältnisses zwischen Schule und Vereinen, Lehrplan und Ehrenamt. Somit stellt das Buch, wie auch das Projekt, einen enorm wichtigen Beitrag zur Geschlechtergerechtigkeit im Sport dar. Gleichzeitig jedoch liest sich eine Reihe an Texten etwas zu sperrig für den Bericht einer Praxisforschung, und Begriffe im Feld der ‚Integration’ bleiben schwammig.

  20. Optimization of LDL targeted nanostructured lipid carriers of 5-FU by a full factorial design

    Directory of Open Access Journals (Sweden)

    Sare Andalib

    2012-01-01

    Full Text Available Background: Nanostructured lipid carriers (NLC are a mixture of solid and liquid lipids or oils as colloidal carrier systems that lead to an imperfect matrix structure with high ability for loading water soluble drugs. The aim of this study was to find the best proportion of liquid and solid lipids of different types for optimization of the production of LDL targeted NLCs used in carrying 5-Fu by the emulsification-solvent evaporation method. Materials and Methods: The influence of the lipid type, cholesterol or cholesteryl stearate for targeting LDL receptors, oil type (oleic acid or octanol, lipid and oil% on particle size, surface charge, drug loading efficiency, and drug released percent from the NLCs were studied by a full factorial design. Results: The NLCs prepared by 54.5% cholesterol and 25% of oleic acid, showed optimum results with particle size of 105.8 nm, relatively high zeta potential of −25 mV, drug loading efficiency of 38% and release efficiency of about 40%. Scanning electron microscopy of nanoparticles confirmed the results of dynamic light scattering method used in measuring the particle size of NLCs. Conclusions: The optimization method by a full factorial statistical design is a useful optimization method for production of nanostructured lipid carriers.

  1. Optimization of LDL targeted nanostructured lipid carriers of 5-FU by a full factorial design.

    Science.gov (United States)

    Andalib, Sare; Varshosaz, Jaleh; Hassanzadeh, Farshid; Sadeghi, Hojjat

    2012-01-01

    Nanostructured lipid carriers (NLC) are a mixture of solid and liquid lipids or oils as colloidal carrier systems that lead to an imperfect matrix structure with high ability for loading water soluble drugs. The aim of this study was to find the best proportion of liquid and solid lipids of different types for optimization of the production of LDL targeted NLCs used in carrying 5-Fu by the emulsification-solvent evaporation method. The influence of the lipid type, cholesterol or cholesteryl stearate for targeting LDL receptors, oil type (oleic acid or octanol), lipid and oil% on particle size, surface charge, drug loading efficiency, and drug released percent from the NLCs were studied by a full factorial design. The NLCs prepared by 54.5% cholesterol and 25% of oleic acid, showed optimum results with particle size of 105.8 nm, relatively high zeta potential of -25 mV, drug loading efficiency of 38% and release efficiency of about 40%. Scanning electron microscopy of nanoparticles confirmed the results of dynamic light scattering method used in measuring the particle size of NLCs. The optimization method by a full factorial statistical design is a useful optimization method for production of nanostructured lipid carriers.

  2. Sequential radiotherapy and chemotherapy using CDDP and 5-FU for advanced head and neck cancer

    International Nuclear Information System (INIS)

    Takamura, Akio; Arimoto, Takuro; Mizoe, Jun-etsu; Tomita, Masayoshi; Kitahara, Toshihiro; Irie, Goro; Matsuoka, Yoshisuke.

    1991-01-01

    From April 1989 to January 1990, nine patients with locally advanced stage IV squamous cell carcinoma of the head and neck underwent combined chemotherapy and radiotherapy (RT). Chemotherapy consisted of two cycles of CDDP (100 mg/m 2 , day 1) + 5-FU (1 g/m 2 , days 1-5, continuous infusion) every five weeks. RT was interdigitated with chemotherapy after the second course of chemotherapy. Each course was initiated two or three days after interrupting chemotherapy. RT was delivered at 65 or 70 Gy for 8 weeks. Of the 7 patients completing the treatment, 29% responded totally, and 43% responded partially. Seven patients died: two due to acute treatment-related toxicity; four due to locoregional progression; and one due to an unrelated cause. Two patients are still alive (10 and 12 months); one is free of tumor, the other has a metastatic bone tumor. Though sequential use of CT might be considered effective for some patients, acute toxicity was moderate to severe and patients with poor performance (≤70%), elderly (≥70 yr) and renal dysfunction (creatinine clearance<80 ml/min) patients must be considered as high risk for treatment by our combined regimen. (author)

  3. [Experimental study on preventing postoperative posterior urethra scar in response to Tablet Fu Kang].

    Science.gov (United States)

    Mo, Jiacong; Wang, Shengyi

    2004-07-01

    To find an effective measurement to prevent and decrease the posterior urethral scar stricture. Twenty New Zealand rabbits were chosen. All the rabbits were made posterior urethra disruption model, and at the same time, the urethra anastomosis operation was performed. Twenty rabbits were divided into two groups after operation at random. One group was treated by Tablet Fu Kang (experimental group), another group was treated by NS (control group). All the rabbits were killed three weeks later, the urethra anastomotic stoma tissue was chosen and stained with Masson. All the figures of slides were inputted into figure analytic system. There were little collagenous fiber, sparsely and arranged in good order in scar tissue of urethra anastomotic stoma in experimental group. The area of collagenous fibers was 117.11 +/- 10.17 microm2 in three visual fields. There were many collagenous fibers, densely,and arranged in disorder in scar tissue of urethra anastomotic stoma in control group, the relative area was 136.43 +/- 15.85 microm2. There was statistic significance when comparing the area of collagenous fiber in two groups (P urethra.

  4. Summary report of Japan-US joint project (TITAN). FuY 2007-2012

    International Nuclear Information System (INIS)

    Okuno, K.; Muroga, T.

    2014-01-01

    This report summarizes the scientific accomplishments achieved through the TITAN Japan-US Collaboration Program. The TITAN collaboration (Tritium, Irradiation and Thermofluid for America and Nippon) has been carried out through six years (FuY 2007-2012) under the collaboration implemented by establishing Annex I to the NIFS-ORNL Agreement on Academic and Scientific Exchange. The TITAN collaboration was established to obtain fundamental understanding for the control of tritium and thermofluid in first wall, blanket and recovery systems with particular emphasis on their interfacial issues. The experiments were designed for testing under conditions specific to fusion, such as intense irradiation, high heat/particle flux, and circulation in a high magnetic field. The results have been applied using integrated modeling to advance the design of tritium and heat control in MFE and IFE systems. This issue is the collection of 34 papers presented at the entitled meeting. All the 34 of the presented papers are indexed individually. (J.P.N.)

  5. Alternative therapy using CDDP/5FU and radiotherapy for nasopharyngeal cancer

    International Nuclear Information System (INIS)

    Shikama, Naoto; Shikano, Masato; Toita, Takafumi; Yuda, Atsushi; Hayashi, Yasuyuki

    2004-01-01

    We conducted a prospective study of an alternative chemoradiation protocol comprising cisplatin (CDDP) (50 mg/m 2 /day, 2 days), 5FU (800 mg/m 2 /day, 5 days) and radiotherapy (66 Gy in 36 fractions) for locally advanced nasopharyngeal cancer (stage II-IV). We treated 67 patients (stage II-III:41 patients, IV:26) using this protocol. Fifty-seven patients (85%) received the full-course, three-cycle chemotherapy. Three-year overall survival rate of all patients was 90.5%, and 3-year disease-free survival rate was 78.3%. The recurrent sites were the primary site in four patients, neck lymph node in two and distant metastasis in eight. Severe myelosuppression (grade 3-4) was observed in half of the patients, and severe mucositis (grade 3-4) in about 30%. Chemotherapy induced severe dysfunction of liver or kidney (grade 3-4) was seen in three patients. This treatment strategy may be very useful, but careful medical management is essential. (author)

  6. A Reactor Development Scenario for the FuZE Sheared-Flow Stabilized Z-pinch

    Science.gov (United States)

    McLean, Harry S.; Higginson, D. P.; Schmidt, A.; Tummel, K. K.; Shumlak, U.; Nelson, B. A.; Claveau, E. L.; Forbes, E. G.; Golingo, R. P.; Stepanov, A. D.; Weber, T. R.; Zhang, Y.

    2017-10-01

    We present a conceptual design, scaling calculations, and development path for a pulsed fusion reactor based on a flow-stabilized Z-pinch. Experiments performed on the ZaP and ZaP-HD devices have largely demonstrated the basic physics of sheared-flow stabilization at pinch currents up to 100 kA. Initial experiments on the FuZE device, a high-power upgrade of ZaP, have achieved 20 usec of stability at pinch current 100-200 kA and pinch diameter few mm for a pinch length of 50 cm. Scaling calculations based on a quasi-steady-state power balance show that extending stable duration to 100 usec at a pinch current of 1.5 MA and pinch length of 50 cm, results in a reactor plant Q 5. Future performance milestones are proposed for pinch currents of: 300 kA, where Te and Ti are calculated to exceed 1-2 keV; 700 kA, where DT fusion power would be expected to exceed pinch input power; and 1 MA, where fusion energy per pulse exceeds input energy per pulse. This work funded by USDOE ARPA-E and performed under the auspices of Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344. LLNL-ABS-734770.

  7. Combination hyperthermia and intraarterial 5-FU for metastatic colon carcinoma to liver

    International Nuclear Information System (INIS)

    Moseley, H.S.; Palmquist, M.

    1984-01-01

    Metastatic colorectal carcinoma to the liver remains a formidable challenge. Responses to chemotherapy are brief and the number of effective drugs is very limited. A phase II trial of hepatic hyperthermia and intraarterial chemotherapy was undertaken to attempt to improve response rates and duration. Patients were given a 10 day course of IA 5-FU at 15 mg/kg. During the infusion hyperthermia was given five times using the BSD Annular Phased Array (APA). Thermistors were placed percutaneously into normal liver and tumor using ultrasound or CT scan guidance. Six patients have been treated. Significant problems in positioning ill patients in the APA were encountered, and there was difficulty also in preventing heating throughout the abdominal cavity. Four patients, all with poor performance status, failed to benefit. One patient had improvement in liver function studies for two months and failed to respond on a repeat course. One patient had a complete response which is continuing over 18 months with a liver scan reverting to normal and CEA returning to normal. These preliminary results are promising and warrant further trials

  8. Electromiographic and kinematic characteristics of Kung Fu Yau-Man palm strike.

    Science.gov (United States)

    Neto, O P; Magini, Marcio

    2008-12-01

    A kinematic and electromyographic analysis of Kung Fu (KF) Yau-Man palm strikes without impact is presented. An empirical model applied to data obtained by a high-speed camera describes the kinematic characteristics of the movement. The electromyographic patterns of the biceps brachii, brachioradialis and triceps brachii muscles were studied during the strike in the time (root mean square) and frequency (wavelet transform) domains. Eight KF practitioners participated in the investigation. A wooden board was placed in front of the subjects, and they were asked to perform the strike imagining a target above the board. The results show that the Yau-Man KF palm strike has very similar kinematic characteristics to a simple moderate speed elbow extension movement. All practitioners positioned themselves in relation to the wooden board in a way to achieve their highest hand speeds in the instant their hands crossed the board. The analyses of the electromyography data shows a well developed muscle coordination of the practitioners in agreement with kinematic results. The results of this paper are important not only for improving the performance of practitioners but also to demonstrate the applicability of KF in the process of motor control development.

  9. Kung fu training improves physical fitness measures in overweight/obese adolescents: the "martial fitness" study.

    Science.gov (United States)

    Tsang, Tracey W; Kohn, Michael R; Chow, Chin Moi; Fiatarone Singh, Maria Antoinette

    2010-01-01

    Aim. To examine the efficacy of a six-month Kung Fu (KF) program on physical fitness in overweight/obese adolescents. Methods. Subjects were randomly assigned to the KF or sham exercise (Tai Chi, TC) control group. Physical measurements in cardiovascular fitness and muscle fitness occurred at baseline and after 6 months of training thrice weekly. Results. Twenty subjects were recruited. One subject was lost to follow-up, although overall compliance to the training sessions was 46.7 +/- 27.8%. At follow-up, the cohort improved in absolute upper (P = .002) and lower (P = .04) body strength, and upper body muscle endurance (P = .02), without group differences. KF training resulted in significantly greater improvements in submaximal cardiovascular fitness (P = .03), lower body muscle endurance (P = .28; significant 95% CI: 0.37-2.49), and upper body muscle velocity (P = .03) relative to TC training. Conclusions. This short-term KF program improved submaximal cardiovascular fitness, lower body muscle endurance, and muscle velocity, in overweight/obese adolescents with very low baseline fitness.

  10. Die Osteonekrose des Fußes: Eine Übersicht

    Directory of Open Access Journals (Sweden)

    Schenk S

    2007-01-01

    Full Text Available Die Osteonekrose (ON am Fuß ist eine heterogene Gruppe von Krankheitsbildern, die sich deutlich hinsichtlich Klinik, Verlauf, Prädilektionsalter und Prognose unterscheiden. Ebenso sind die Ursachen für diese Erkrankungen vielfältig: Neben idiopathischen finden sich auch posttraumatische und postoperative Formen. Seltene Ursachen sind Kollagenosen, Stoffwechselerkrankungen wie Diabetes mellitus und Kortikoidtherapie. ON finden sich gehäuft nach Nierentransplantationen. Je nach Ursache tritt eine ON gehäuft in typischer Lokalisation auf. Idiopathische Formen findet man am Os naviculare pedis – Morbus Köhler 1 (MK1, an den Metatarsaleköpfchen – Morbus Köhler 2, "Freiberg’s disease" (MK2, an den Sesambeinen und an der Apophyse des Calcaneus. Operationsbedingte Fälle sind gehäuft am Metatarsaleköpfchen 1 nach Versorgung eines Hallux valgus lokalisiert, posttraumatische Nekrosen am Talus. In diesem Artikel werden die idiopathischen Formen hinsichtlich Klinik und Therapie näher beleuchtet. Bezüglich der Therapie gibt es konservative und operative Ansätze. Die wissenschaftlichen Daten zur Behandlung von idiopathischen Nekrosen sind spärlich, die Behandlungsstrategien jedoch einheitlich und allgemein anerkannt.

  11. Enteric coated HPMC capsules plugged with 5-FU loaded microsponges: a potential approach for treatment of colon cancer

    Directory of Open Access Journals (Sweden)

    Ankita Gupta

    2015-09-01

    Full Text Available The work was aimed at developing novel enteric coated HPMC capsules (ECHC plugged with 5 Florouracil (5-FU loaded Microsponges in combination with calcium pectinate beads. Modified quasi-emulsion solvent diffusion method was used to formulate microsponges based on 32 factorial design and the effects of independent variables (volume of organic solvent and Eudragit RS100 content on the dependent variables (Particle size, %EE & % CDR were determined. The optimized microsponges (F4 were characterized by SEM, PXRD, TGA and were plugged along with calcium pectinate beads in HPMC capsules and the HPMC capsules were further coated with enteric polymer Eudragit L 100 (Ed-L100 and/ or Eudrgit S 100 (Ed-S 100 in different proportions. In vitro release study of ECHC was performed in various release media sequentially SGF for 2 h, followed by SIF for the next 6 h and then in SCF (in the presence and absence of pectinase enzyme for further 16 h. Drug release was retarded on coating with EdS-100 in comparison to blend of EdS-100: EdL-100 coating. The percentage of 5-FU released at the end of 24 h from ECHC 3 was 97.83 ± 0.12% in the presence of pectinase whereas in control study it was 40.08 ± 0.02% drug. The optimized formulation was subjected to in vivo Roentgenographic studies in New Zealand white rabbits to analyze the in vivo behavior of the developed colon targeted capsules. Pharmacokinetic studies in New Zealand white rabbits were conducted to determine the extent of systemic exposure provided by the developed formulation in comparison to 5-FU aqueous solutions. Thus, enteric coated HPMC capsules plugged with 5-FU loaded microsponges and calcium pectinate beads proved to be promising dosage form for colon targeted drug delivery to treat colorectal cancer.

  12. Preoperative 5-FU, low-dose leucovorin, and radiation therapy for locally advanced and unresectable rectal cancer

    International Nuclear Information System (INIS)

    Minsky, Bruce D.; Cohen, Alfred M.; Enker, Warren E.; Saltz, Leonard; Guillem, Jose G.; Paty, Philip B.; Kelsen, David P.; Kemeny, Nancy; Ilson, David; Bass, Joanne; Conti, John

    1997-01-01

    Purpose: We report the local control and survival of two Phase I dose escalation trials of combined preoperative 5-fluorouracil (5-FU), low-dose leucovorin (LV), and radiation therapy followed by postoperative LV/5-FU for the treatment of patients with locally advanced and unresectable rectal cancer. Methods and Materials: A total of 36 patients (30 primary and 6 recurrent) received two monthly cycles of LV/5-FU (bolus daily x 5). Radiation therapy (50.40 Gy) began on day 1 in the 25 patients who received concurrent treatment and on day 8 in the 11 patients who received sequential treatment. Postoperatively, patients received a median of four monthly cycles of LV/5-FU. Results: The resectability rate with negative margins was 97%. The complete response rate was 11% pathologic and 14% clinical for a total of 25%. The 4-year actuarial disease-free survival was 67% and the overall survival was 76%. The crude local failure rate was 14% and the 4-year actuarial local failure rate was 30%. Crude local failure was lower in the four patients who had a pathologic complete response (0%) compared with those who either did not have a pathologic complete response (16%) or who had a clinical complete response (20%). Conclusion: Our preliminary data with the low-dose LV regimen reveal encouraging downstaging, local control, and survival rates. Additional follow-up is needed to determine the 5-year results. The benefit of downstaging on local control is greatest in patients who achieve a pathologic complete response

  13. Prof. Wu Xiaoqiu:China Is Striving for the World's Most Developed Capital Market

    Institute of Scientific and Technical Information of China (English)

    Sun Yongjian; Zhang Yue

    2007-01-01

    @@ China's capital market is a hot issue in the new year. The best strategy to develop the Chinese capital market in the coming 15 to 20 years was discussed in the China Capital Market Forum, which was held in China at Renmin University on January 13. Government officials, scholars, and entrepreneurs commented that by 2020, the Chinese capital market will develop into one of the best capital markets in the world,not only in terms of size, but also asset quality, liquidity and dynamic trade. Is this a realistic goal? What steps should we take to pursue this target? With these questions in mind, after the forum, China's Foreign Trade interviewed Prof. Wu Xiaoqiu, Vice President of Renmin University of China,and the Director of the Finance & Securities Institute of Renmin University.

  14. New Hypersonic Shock Tunnel at the Laboratory of Aerothermodynamics and Hypersonics Prof. Henry T. Nagamatsu

    International Nuclear Information System (INIS)

    Toro, P. G. P.; Minucci, M. A. S.; Chanes, J. B. Jr; Oliveira, A. C.; Gomes, F. A. A.; Myrabo, L. N.; Nagamatsu, Henry T.

    2008-01-01

    The new 0.60-m. nozzle exit diameter hypersonic shock tunnel was designed to study advanced air-breathing propulsion system such as supersonic combustion and/or laser technologies. In addition, it may be used for hypersonic flow studies and investigations of the electromagnetic (laser) energy addition for flow control. This new hypersonic shock tunnel was designed and installed at the Laboratory for of Aerothermodynamics and Hypersonics Prof. Henry T. Nagamatsu, IEAv-CTA, Brazil. The design of the tunnel enables relatively long test times, 2-10 milliseconds, suitable for the experiments performed at the laboratory. Free stream Mach numbers ranging from 6 to 25 can be produced and stagnation pressures and temperatures up to 360 atm. and up to 9,000 K, respectively, can be generated. Shadowgraph and schlieren optical techniques will be used for flow visualization

  15. KONSTRUKSI EPISTEMOLOGI PENDIDIKAN ISLAM (Studi atas Pemikiran Kependidikan Prof. H. M. Arifin, M. Ed

    Directory of Open Access Journals (Sweden)

    = Abdul Ghofur =

    2016-12-01

    Full Text Available Epistemology of Islamic education is the object of knowledge, how to acquire knowledge and how to measure whether or not the knowledge related to the formation of personality, character, develop nature and all of human potential to the maximum to become good Muslims, have the mindset of a logical-critical, faithful, devoted, useful for themselves and their environment, and can achieve happiness in this world and in the hereafter in accordance with Islamic teachings. While Prof. H. M. Muzayin Arifin, M.Ed. epistemology of Islamic Education establish the truth of knowledge by measuring this knowledge by using Scientific through models of educational research that is based on Islamic values.

  16. Van autonomie terug naar natuurlijk­heid? Een reactie op prof.dr. H.M. Dupuis

    NARCIS (Netherlands)

    Boer, Th.A.

    Wie de inleidingen van Prof. Dupuis en Mgr. Eijk leest, kan zich moeilijk aan de indruk onttrekken dat zij het onderling behoorlijk eens zijn. Dat verbaast, want Eijk staat bekend als een aanhanger van het natuurrecht zoals geïnterpreteerd in de rooms-katholieke traditie en Dupuis als een

  17. Producing High-Performance, Stable, Sheared-Flow Z-Pinches in the FuZE project

    Science.gov (United States)

    Golingo, R. P.; Shumlak, U.,; Nelson, B. A.; Claveau, E. L.; Forbes, E. G.; Stepanov, A. D.; Weber, T. R.; Zhang, Y.; McLean, H. S.; Tummel, K. K.; Higginson, D. P.; Schmidt, A. E.; University of Washington (UW) Collaboration; Lawrence Livermore National Laboratory (LLNL) Collaboration

    2017-10-01

    The Fusion Z-Pinch Experiment (FuZE) has made significant strides towards generating high-performance, stable Z-pinch plasmas with goals of ne = 1018 cm-3 and T =1 keV. The Z-pinch plasmas are stabilized with a sheared axial flow that is driven by a coaxial accelerator. The new FuZE device has been constructed and reproduces the major scientific achievements the ZaP project at the University of Washington; ne = 1016 cm-3,T = 100 eV, r20 μs. These parameters are measured with an array of magnetic field probes, spectroscopy, and fast framing cameras. The plasma parameters are achieved using a small fraction of the maximum energy storage and gas injection capability of the FuZE device. Higher density, ne = 5×1017 cm-3, and temperature, T = 500 eV, Z-pinch plasmas are formed by increasing the pinch current. At the higher voltages and currents, the ionization rates in the accelerator increase. By modifying the neutral gas profile in the accelerator, the plasma flow from the accelerator is maintained, driving the flow shear. Formation and sustainment of the sheared-flow Z-pinch plasma will be discussed. Experimental data demonstrating high performance plasmas in a stable Z-pinches will be shown. This work is supported by an award from US ARPA-E.

  18. TS gene polymorphisms are not good markers of response to 5-FU therapy in stage III colon cancer patients.

    Science.gov (United States)

    Fariña-Sarasqueta, A; Gosens, M J E M; Moerland, E; van Lijnschoten, I; Lemmens, V E P P; Slooter, G D; Rutten, H J T; van den Brule, Adriaan J C

    2011-08-01

    Although the predictive and prognostic value of thymidylate synthase (TS) expression and gene polymorphism in colon cancer has been widely studied, the results are inconclusive probably because of methodological differences. With this study, we aimed to elucidate the role of TS gene polymorphisms genotyping in therapy response in stage III colon carcinoma patients treated with 5-FU adjuvant chemotherapy. 251 patients diagnosed with stage III colon carcinoma treated with surgery followed by 5-FU based adjuvant therapy were selected. The variable number of tandem repeats (VNTR) and the single nucleotide polymorphism (SNP) in the 5'untranslated region of the TS gene were genotyped. There was a positive association between tumor T stage and the VNTR genotypes (p = 0.05). In both univariate and multivariate survival analysis no effects of the studied polymorphisms on survival were found. However, there was an association between both polymorphisms and age. Among patients younger than 60 years, the patients homozygous for 2R seemed to have a better overall survival, whereas among the patients older than 67 this longer survival was seen by the carriers of other genotypes. We conclude that the TS VNTR and SNP do not predict response to 5-FU therapy in patients with stage III colon carcinoma. However, age appears to modify the effects of TS polymorphisms on survival.

  19. Spectral energy distribution analysis of class I and class II FU Orionis stars

    Energy Technology Data Exchange (ETDEWEB)

    Gramajo, Luciana V.; Gómez, Mercedes [Observatorio Astronómico, Universidad Nacional de Córdoba, Argentina, Laprida 854, 5000 Córdoba (Argentina); Rodón, Javier A., E-mail: luciana@oac.uncor.edu, E-mail: mercedes@oac.uncor.edu, E-mail: jrodon@eso.org [European Southern Observatory, Alonso de Córdova 3107, Vitacura, Casilla 19001, Santiago 19 (Chile)

    2014-06-01

    FU Orionis stars (FUors) are eruptive pre-main sequence objects thought to represent quasi-periodic or recurring stages of enhanced accretion during the low-mass star-forming process. We characterize the sample of known and candidate FUors in a homogeneous and consistent way, deriving stellar and circumstellar parameters for each object. We emphasize the analysis in those parameters that are supposed to vary during the FUor stage. We modeled the spectral energy distributions of 24 of the 26 currently known FUors, using the radiative transfer code of Whitney et al. We compare our models with those obtained by Robitaille et al. for Taurus class II and I sources in quiescence periods by calculating the cumulative distribution of the different parameters. FUors have more massive disks: we find that ∼80% of the disks in FUors are more massive than any Taurus class II and I sources in the sample. Median values for the disk mass accretion rates are ∼10{sup –7} M {sub ☉} yr{sup –1} versus ∼10{sup –5} M {sub ☉} yr{sup –1} for standard young stellar objects (YSOs) and FUors, respectively. While the distributions of envelope mass accretion rates for class I FUors and standard class I objects are similar, FUors, on average, have higher envelope mass accretion rates than standard class II and class I sources. Most FUors (∼70%) have envelope mass accretion rates above 10{sup –7} M {sub ☉} yr{sup –1}. In contrast, 60% of the classical YSO sample has an accretion rate below this value. Our results support the current scenario in which changes experimented by the circumstellar disk explain the observed properties of these stars. However, the increase in the disk mass accretion rate is smaller than theoretically predicted, although in good agreement with previous determinations.

  20. Physiological, performance, and nutritional profile of the Brazilian Olympic Wushu (kung-fu) team.

    Science.gov (United States)

    Artioli, Guilherme Giannini; Gualano, Bruno; Franchini, Emerson; Batista, Rafael Novaes; Polacow, Viviane Ozores; Lancha, Antonio Herbert

    2009-01-01

    The purpose of the present study was to determine physiological, nutritional, and performance profiles of elite Olympic Wushu (kung-fu) athletes. Ten men and four women elite athletes took part in the study. They completed the following tests: body composition, nutritional assessment, upper-body Wingate Test, vertical jump, lumbar isometric strength, and flexibility. Blood lactate was determined at rest and after the Wingate Test. Blood lactate was also determined during a training session (combat and Taolu training). We found low body fat (men: 9.5 +/- 6.3%; women: 18.0 +/- 4.8%), high flexibility (sit-and-reach-men: 45.5 +/- 6.1 cm; women: 44.0 +/- 6.3 cm), high leg power (vertical jump-men: 37.7 +/- 8.4 cm; women: 32.3 +/- 1.1 cm), high lumbar isometric strength (men: 159 +/- 13 cm; women: 94 +/- 6 cm), moderate arm mean and peak power (Wingate Test-men: 4.1 +/- 0.4 and 5.8 +/- 0.5 Wxkg, respectively; women: 2.5 +/- 0.3 and 3.4 +/- 0.3 W.kg, respectively), and elevated blood lactate after the Wingate Test (men: 10.8 +/- 2.0 mmolxL; women: 10.2 +/- 2.0 mmolxL) and during training (combat: 12.0 +/- 1.8 mmolxL; Taolu: 7.7 +/- 3.3 mmolxL). Men athletes consume a high-fat, low-carbohydrate diet, whereas women consume a moderate, high-carbohydrate diet. Energy consumption was markedly variable. In conclusion, Olympic Wushu seems to be a highly anaerobic-dependent combat sport. Low body fat, high flexibility, leg anaerobic power, isometric strength, and moderately high arm anaerobic power seem to be important for successful competitive performance.

  1. Post-operative chemosensitized radiation with modulated 5-fluorouracil (5-FU) following resection of adenocarcinoma of the esophagus and esophagogastric (EG) junction

    International Nuclear Information System (INIS)

    Kurtzman, S.M.; Whittington, R.; Vaughn, D.; Rosato, E.F.; Haller, D.G.

    1995-01-01

    Purpose: To evaluate the survival and toxicity of post-operative chemosensitized radiation with modulated 5-FU chemotherapy in patients with resected adenocarcinomas of the esophagus and EG junction. Materials and Methods: One hundred and ninety-two patients with localized adenocarcinomas of the esophagus and EG junction were treated with single or combined modality therapy. The results in the first 165 patients treated between 1972 and 1989 demonstrated that survival was improved with chemosensitized radiation therapy following surgical resection. In the final group of patients treated between 1985 and 1989 a 96 hour inpatient 5-FU infusion was used to provide chemosensitization in those patients. Twenty-seven patients have been treated between January 1990 and December 1994 using a new outpatient regimen with modulated 5-FU chemotherapy for chemosensitization. Radiation and chemotherapy commenced within 6 weeks of surgery. The dose of radiation was 54 Gy in patients with no residual tumor, and 59.4 to 63.0 Gy in patients with positive margins or residual tumor. Modulated 5-FU using bolus 5-FU with Leukovorin +/-α-interferon (α-IFN) was given during the first and fifth week of radiation. Results: Median follow-up of surviving patients treated with modulated 5-FU is 15 months (max - 46 mos). Survival is 71% at 1 year, 45% at 2 years and 39% at 3 years. This compares favorably with the survival with 5-FU infusion, 75% - 1 year, 35% - 2 year, and 10% - 3 year. The toxicity of modulated 5-FU was no different from that observed in patients treated with 5-FU infusion. Three patients treated with modulated 5-FU leukovorin and α-IFN required intravenous hydration, and two patients experienced grade 3 leukopenia. There were two radiation related events in these patients, one case of radiation pneumonitis and one patient with pericarditis. Conclusions: Based on this experience, aggressive therapy of adenocarcinomas of the esophagus and EG junction with surgery and

  2. Preoperative Capecitabine and Pelvic Radiation in Locally Advanced Rectal Cancer-Is it Equivalent to 5-FU Infusion Plus Leucovorin and Radiotherapy?

    International Nuclear Information System (INIS)

    Chan, Alexander K.; Wong, Alfred O.; Jenken, Daryl A.

    2010-01-01

    Purpose: The aim of this retrospective case-matching study was to compare the treatment outcomes and acute toxicity of preoperative radiotherapy (RT) with capecitabine vs. preoperative RT with intermittent 5-fluorouracil (5-FU) infusion, leucovorin, and mitomycin C in rectal cancer. Methods and Materials: We matched 34 patients who were treated with preoperative concurrent capecitabine and 50 Gy of RT by their clinical T stage (T3 or T4) and the tumor location (≤7 cm or >7 cm from the anal verge) with another 68 patients who were treated with preoperative intermittent 5-FU infusion, leucovorin, mitomycin C, and 50 Gy of RT for a comparison of the pathologic tumor response, local control, distant failure, and survival rates. Results: The pathologic complete response rate was 21% with capecitabine and 18% with 5-FU and leucovorin (p = 0.72). The rate of T downstaging after chemoradiation was 59% for both groups. The rate of sphincter-sparing resection was 38% after capecitabine plus RT and 43% after 5-FU plus RT (p = 0.67). At 3 years, there was no significant difference in the local control rate (93% for capecitabine and 92% for 5-FU and leucovorin), relapse-free rate (74% for capecitabine and 73% for 5-FU and leucovorin), or disease-specific survival rate (86% for capecitabine and 77% for 5-FU and leucovorin). The acute toxicity profile was comparable, with little Grade 3 and 4 toxicity. Conclusions: When administered with concurrent preoperative RT, both capecitabine and intermittent 5-FU infusion with leucovorin modulation provided comparable pathologic tumor response, local control, relapse-free survival, and disease-specific survival rates in rectal cancer.

  3. Apigenin potentiates the antitumor activity of 5-FU on solid Ehrlich carcinoma: Crosstalk between apoptotic and JNK-mediated autophagic cell death platforms

    Energy Technology Data Exchange (ETDEWEB)

    Gaballah, Hanaa H., E-mail: hanaahibishy@hotmail.com [Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Tanta University, Tanta, 3111 (Egypt); Gaber, Rasha A. [Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Tanta University, Tanta, 3111 (Egypt); Mohamed, Darin A. [Histopathology Department, Faculty of Medicine, Tanta University, Tanta, 3111 (Egypt)

    2017-02-01

    Background: Although 5- Fluorouracil (5-FU) has exhibited effectiveness against cancer, novel therapeutic strategies are needed to enhance its antitumor efficiency and modulate its cytotoxity. Apigenin, a flavonoid present in fruits and vegetables, is a potent dietary phytochemical effective in cancer chemoprevention. Aim: This study was undertaken to investigate the potential synergistic antitumor activity of apigenin and 5-FU on Solid Ehrlich carcinoma (SEC). Methods: Eighty Swiss albino male mice were divided into four equal groups: vehicle treated control SEC, SEC + 5-FU, SEC + apigenin, SEC + 5-FU + apigenin. Beclin-1 and caspases 3, 9 and JNK activities were estimated by ELISA; mRNA expression levels of the antiapoptotic gene Mcl-1 were estimated using quantitative real-time RT-PCR, while tissue malondialdehyde (MDA), glutathione peroxidase and total antioxidant capacity were evaluated spectrophotometrically. A part of the tumor was examined for histopathological and Ki-67 immunohistochemistry analysis. Results: 5-FU and/or apigenin caused significant increase in tissue levels of Beclin-1, caspases 3, 9 and JNK activities, MDA with significant decrease in tumor volume, Mcl-1expression, tissue glutathione peroxidase and total antioxidant capacity and alleviated the histopathological changes with significant decrease of Ki-67 proliferation index compared to vehicle treated SEC control group. In conclusion: The combination of 5-FU and apigenin had a greater effect than each of 5-FU or apigenin alone against solid Ehrlich carcinoma in mice. - Highlights: • Apigenin potentiated 5-FU cytotoxicity in EAC solid tumor models in vivo. • It acted via autophagy stimulation, downregulating MCL-1 and Ki-67 expression. • It caused JNK activation and ROS accumulation; resulted in tumor growth inhibition. • Apigenin can be used as a co-adjuvant agent in cancer therapy.

  4. [Study of the immunological mechanism of anti-tumor effects of 5-FU by establishing EL4 tumor-bearing mouse models].

    Science.gov (United States)

    Li, Mo-Lin; Li, Chuan-Gang; Shu, Xiao-Hong; Li, Ming-Xia; Jia, Yu-Jie; Qin, Zhi-Hai

    2007-11-01

    To investigate the immunological mechanism of anti-tumor effect of 5-FU by establishing lymphoma EL4 tumor-bearing mouse models in wild type C57BL/6 mice and nude C57BL/6 mice, respectively. The mouse lymphoma EL4 cells were inoculated subcutaneously into wild type C57BL/6 mice (immune-competent mice). Twelve days later, 5-FU of different doses was administered intraperitoneally to treat these wild type C57BL/6 tumor-bearing mice. The size of tumors in the wild type C57BL/6 mice was observed and recorded to explore the minimal dose of 5-FU that could cure the tumor-bearing mice. Then the same amount of EL4 tumor cells was inoculated subcutaneously into wild type C57BL/6 mice and nude C57BL/6 mice (T cell-deficient mice) simultaneously, which had the same genetic background of C57BL/6. Twelve days later, 5-FU of the minimal dose was given intraperitoneally to treat both the wild type and nude C57BL/6 tumor-bearing mice. The size of tumors in the two different types of mice was observed and recorded. A single dose of 5-FU (75 mg/kg) cured both the EL4 tumor-bearing wild type C57BL/6 mice and the EL4 tumor-bearing nude C57BL/6 mice in the first week. Two weeks after 5-FU treatment, all of the nude mice died of tumor relapse while most of the wild type C57BL/6 mice were fully recovered. A single dose of 5-FU has marked anti-tumor effects on lymphoma EL4 tumor-bearing C57BL/6 mice with or without T lymphocytes. The relapse of tumors after 5-FU treatment might be related to the function of T lymphocytes.

  5. Synthesis, characterization and in vitro evaluation of magnetic nanoparticles modified with PCL-PEG-PCL for controlled delivery of 5FU.

    Science.gov (United States)

    Asadi, Nahideh; Annabi, Nasim; Mostafavi, Ebrahim; Anzabi, Maryam; Khalilov, Rovshan; Saghfi, Siamak; Mehrizadeh, Masoud; Akbarzadeh, Abolfazl

    2018-02-22

    Magnetic nanoparticles have properties that cause to apply them in cancer therapy and vehicles for the delivery of drugs such as 5FU, especially when they are modified with biocompatible copolymers. The aim of this study is to modify superparamagnetic iron oxide nanoparticles (SPIONPs) with PCL-PEG-PCL copolymers and then utilization of these nanoparticles for encapsulation of anticancer drug 5FU. The ring-opening polymerization (ROP) was used for the synthesis of PCL-PEG-PCL copolymer by ε-caprolactone (PCL) and polyethylene glycol (PEG2000). We used the double emulsion method (water/oil/water) to prepare 5FU-encapsulated Fe 3 O 4 magnetic nanoparticles modified with PCL-PEG-PCL copolymer. Chemical structure and magnetic properties of 5FU-loaded magnetic-polymer nanoparticles were investigated systematically by employing FT-IR, XRD, VSM and SEM techniques. In vitro release profile of 5FU-loaded NPs was also determined. The results showed that the encapsulation efficiency value for nanoparticles were 90%. Moreover, the release of 5FU is significantly higher at pH 5.8 compared to pH 7.4. Therefore, these nanoparticles have sustained release and can apply for cancer therapy.

  6. Some Components of Philosophical nature Constitutives of Prof. Mario Tourasse Teixeira’s Thought Alguns Elementos de Natureza Filosófica Constitutivos do Pensamento do Prof. Mario Tourasse Teixeira

    Directory of Open Access Journals (Sweden)

    Romélia Mara Alves Souto

    2008-02-01

    Full Text Available In this paper I endeavor to show the interest shown by Prof. Mario Tourasse Teixeira with respect to the production of mathematical knowledge and the ideas underlying the concepts of creativity in mathematics which he used and which permeate the work he supervised. My aim was to organize ideas dispersed throughout the work produced by his pupils, recorded in manuscripts or elaborated as texts and published by Prof. Tourasse in SAPO newsletters. In an attempt to capture his thoughts on Mathematics and Education, I tried to establish connections between documents which, explicitly or not, bear his mark. I believe that the merit of this effort lies in organizing, systematizing and presenting, for the first time, a draft of Prof. Mario Tourasse Teixeira’s mathematical-philosophical thought. Keywords: Mario Tourasse Teixeira. Mathematics History. Mathematics Education. History of Mathematics Education.Neste trabalho procuro mostrar o interesse que o Prof. Mario Tourasse Teixeira manifestava em relação ao dinamismo do conhecimento matemático e as idéias subjacentes ao conceito de criatividade em matemática por ele utilizado e que permeiam todos os trabalhos que orientou. Meu intuito foi organizar idéias dispersas em vários trabalhos realizados por seus alunos, registradas em alguns manuscritos ou elaboradas em textos publicados pelo Prof. Mario Tourasse, anonimamente, nos boletins do SAPO. Na tentativa de captar seu pensamento sobre Matemática e Educação, busquei estabelecer conexões entre os diversos documentos que, explicitamente ou não, guardam seu registro. Acredito que o mérito desse esforço reside em organizar, sistematizar e apresentar pela primeira vez, um esboço do pensamento matemático-filosófico do Prof. Mario Tourasse Teixeira. Palavras-chave: Mario Tourasse Teixeira. História da Matemática. Educação Matemática. História da Educação Matemática.

  7. The compound Chinese medicine "Kang Fu Ling" protects against high power microwave-induced myocardial injury.

    Science.gov (United States)

    Zhang, Xueyan; Gao, Yabing; Dong, Ji; Wang, Shuiming; Yao, Binwei; Zhang, Jing; Hu, Shaohua; Xu, Xinping; Zuo, Hongyan; Wang, Lifeng; Zhou, Hongmei; Zhao, Li; Peng, Ruiyun

    2014-01-01

    The prevention and treatment of Microwave-caused cardiovascular injury remains elusive. This study investigated the cardiovascular protective effects of compound Chinese medicine "Kang Fu Ling" (KFL) against high power microwave (HPM)-induced myocardial injury and the role of the mitochondrial permeability transition pore (mPTP) opening in KFL protection. Male Wistar rats (100) were divided into 5 equal groups: no treatment, radiation only, or radiation followed by treatment with KFL at 0.75, 1.5, or 3 g/kg/day. Electrocardiography was used to Electrophysiological examination. Histological and ultrastructural changes in heart tissue and isolated mitochondria were observed by light microscope and electron microscopy. mPTP opening and mitochondrial membrane potential were detected by confocal laser scanning microscopy and fluorescence analysis. Connexin-43 (Cx-43) and endothelial nitric oxide synthase (eNOS) were detected by immunohistochemistry. The expression of voltage-dependent anion channel (VDAC) was detected by western blotting. At 7 days after radiation, rats without KFL treatment showed a significantly lower heart rate (P<0.01) than untreated controls and a J point shift. Myocyte swelling and rearrangement were evident. Mitochondria exhibited rupture, and decreased fluorescence intensity, suggesting opening of mPTP and a consequent reduction in mitochondrial membrane potential. After treatment with 1.5 g/kg/day KFL for 7 d, the heart rate increased significantly (P<0.01), and the J point shift was reduced flavorfully (P<0.05) compared to untreated, irradiated rats; myocytes and mitochondria were of normal morphology. The fluorescence intensities of dye-treated mitochondria were also increased, suggesting inhibition of mPTP opening and preservation of the mitochondrial membrane potential. The microwave-induced decrease of Cx-43 and VDAC protein expression was significantly reversed. Microwave radiation can cause electrophysiological, histological and

  8. The compound Chinese medicine "Kang Fu Ling" protects against high power microwave-induced myocardial injury.

    Directory of Open Access Journals (Sweden)

    Xueyan Zhang

    Full Text Available BACKGROUND: The prevention and treatment of Microwave-caused cardiovascular injury remains elusive. This study investigated the cardiovascular protective effects of compound Chinese medicine "Kang Fu Ling" (KFL against high power microwave (HPM-induced myocardial injury and the role of the mitochondrial permeability transition pore (mPTP opening in KFL protection. METHODS: Male Wistar rats (100 were divided into 5 equal groups: no treatment, radiation only, or radiation followed by treatment with KFL at 0.75, 1.5, or 3 g/kg/day. Electrocardiography was used to Electrophysiological examination. Histological and ultrastructural changes in heart tissue and isolated mitochondria were observed by light microscope and electron microscopy. mPTP opening and mitochondrial membrane potential were detected by confocal laser scanning microscopy and fluorescence analysis. Connexin-43 (Cx-43 and endothelial nitric oxide synthase (eNOS were detected by immunohistochemistry. The expression of voltage-dependent anion channel (VDAC was detected by western blotting. RESULTS: At 7 days after radiation, rats without KFL treatment showed a significantly lower heart rate (P<0.01 than untreated controls and a J point shift. Myocyte swelling and rearrangement were evident. Mitochondria exhibited rupture, and decreased fluorescence intensity, suggesting opening of mPTP and a consequent reduction in mitochondrial membrane potential. After treatment with 1.5 g/kg/day KFL for 7 d, the heart rate increased significantly (P<0.01, and the J point shift was reduced flavorfully (P<0.05 compared to untreated, irradiated rats; myocytes and mitochondria were of normal morphology. The fluorescence intensities of dye-treated mitochondria were also increased, suggesting inhibition of mPTP opening and preservation of the mitochondrial membrane potential. The microwave-induced decrease of Cx-43 and VDAC protein expression was significantly reversed. CONCLUSION: Microwave radiation can

  9. Maps of Relocation and Poems of Tang Dynasty Poets: Li Bai, Du Fu, and Han Yu

    Directory of Open Access Journals (Sweden)

    羅鳳珠、白璧玲、廖泫銘、范毅軍 、鄭錦全 Feng-Ju Lo,Pi-Ling Pai,Hsiung-Ming Liao,I-Chun Fan,Chin-Chuan Cheng

    2014-04-01

    Full Text Available Geographic environments affect literary contents and genre and thus, since ancient times, geographical area has been used to classify Chinese literature. In 1936 Liang Qichao was keenly aware of the relationship between literature and geography and brought up the idea of “literarygeography”. In 1979 Professor Chen Zhengxiang produced maps of birthplaces of Tang and Song poets to show the shift of Chinese cultural center from north to south. Furthermore, in the pastdecade, the attention to research in literary geography and geographical distribution of writersgradually increased. However, most studies focused on geographical distribution of birthplaces of writers and very few focused on the relationship between poets’ journey and the contents of their writings and their geographic environment. Meanwhile, geographic information system and aerialphotography have developed quickly and have become useful tools for the study of literary geography.Since then, the academic circles in Taiwan have built a solid foundation in this area. While Li Baiand Du Fu were called poetic immortal and poetic sage of the middle and end periods of the heydayof Tang Dynasty, respectively, Han Yu advocated the classical Chinese movement and becameone of the eight great authors of Tang and Song dynasties. Han Yu was also the best representative of Middle Tang poets. While the styles of these three poets differed from each other, they held key positions in the development and evolution of Tang poetry. Their footprints spread all over the countryand greatly affected later developments and contemporary of poetry. This project makes use of the digital Tang Dynasty maps by Tan Qixiang, Tang Dynasty transportation route maps by Yan Gengwang,aerial maps, the All Tang Poems, and chronicles of the poets to build the three poets’ relocation maps and study their poetic literature, language, geography, and interactions with others, in hopesof opening a new research direction

  10. A randomized phase III multicenter trial comparing irinotecan in combination with the Nordic bolus 5-FU and folinic acid schedule or the bolus/infused de Gramont schedule (Lv5FU2) in patients with metastatic colorectal cancer

    DEFF Research Database (Denmark)

    Glimelius, B; Sørbye, H; Balteskard, L

    2008-01-01

    not differ (4% versus 6%, P = 0.3). Grade 3/4 neutropenia (11% versus 5%, P = 0.01) and grade 2 alopecia (18% versus 9%, P = 0.002) were more common in the FLIRI group. The 60-day mortality was 2.4% versus 2.1%. CONCLUSIONS: Irinotecan with the bolus Nordic schedule (FLIRI) is a convenient treatment with PFS...... and OS comparable to irinotecan with the Lv5FU2 schedule. Neutropenia and alopecia are more prevalent, but both regimens are equally well tolerated....

  11. Electromyographic Study of a Sequence of Yau-Man Kung Fu Palm Strikes with and without Impact.

    Science.gov (United States)

    Neto, Osmar Pinto; Magini, Marcio; Pacheco, Marcos T T

    2007-01-01

    IN MARTIAL ARTS AND CONTACT SPORTS, STRIKES ARE OFTEN TRAINED IN TWO DIFFERENT WAYS: with and without impacts. This study aims to compare the electromyographical activity (EMG) of the triceps brachii (TB), biceps brachii (BB) and brachioradialis (BR) muscles during strikes with and without impacts. Eight Yau-Man Kung Fu practitioners participated in the experiment. Each participant performed 5 sequences of 5 consecutive KF Yau-Man palm strikes with no impact intercalated with 5 sequences of 5 repetitions targeting a KF training shield. Surface EMG signals were obtained from the TB, BB, and RB for 3.0 seconds using an eight-channel module with a total amplifier gain of 2000 and sampled at 3500 Hz. The EMG analyses were done in the time (rms) and frequency (wavelet) domains. For the frequency domain, Morlet wavelet power spectra were obtained and an original method was used to quantify statistically significant regions on the power spectra. The results both in the time and frequency domains indicate a higher TB and BR muscle activity for the strikes with impacts. No significant difference was found for the BB in the two different scenarios. In addition, the results show that the wavelet power spectra pattern for the three analysed muscles obtained from the strikes with and without impacts were similar. Key pointsEMG analysis of a sequence of Kung Fu strikes demonstrates higher Triceps Brachii and Brachioradialis muscle activity for strikes with impact than strikes without impact.An original reliable method for quantifying EMG wavelet transform results is presented.EMG wavelet power spectra describe muscle roles during a Kung Fu sequence of strikes.

  12. MULTIWAVELENGTH OBSERVATIONS OF V2775 Ori, AN OUTBURSTING PROTOSTAR IN L 1641: EXPLORING THE EDGE OF THE FU ORIONIS REGIME

    Energy Technology Data Exchange (ETDEWEB)

    Fischer, William J.; Megeath, S. Thomas; Kounkel, Marina [Department of Physics and Astronomy, University of Toledo, 2801 West Bancroft Street, Toledo, OH 43606 (United States); Tobin, John J. [National Radio Astronomy Observatory, 520 Edgemont Road, Charlottesville, VA 22903 (United States); Stutz, Amelia M.; Henning, Thomas [Max-Planck-Institut fuer Astronomie, Koenigstuhl 17, D-69117 Heidelberg (Germany); Ali, Babar [NHSC/IPAC/Caltech, 770 South Wilson Avenue, Pasadena, CA 91125 (United States); Remming, Ian; Manoj, P. [Department of Physics and Astronomy, 500 Wilson Boulevard, University of Rochester, Rochester, NY 14627 (United States); Stanke, Thomas [ESO, Karl-Schwarzschild-Strasse 2, D-85748 Garching bei Muenchen (Germany); Osorio, Mayra [Instituto de Astrofisica de Andalucia, CSIC, Camino Bajo de Huetor 50, E-18008, Granada (Spain); Wilson, T. L., E-mail: wfische@utnet.utoledo.edu [Naval Research Laboratory, 4555 Overlook Avenue SW, Washington, DC 20375 (United States)

    2012-09-01

    Individual outbursting young stars are important laboratories for studying the physics of episodic accretion and the extent to which this phenomenon can explain the luminosity distribution of protostars. We present new and archival data for V2775 Ori (HOPS 223), a protostar in the L 1641 region of the Orion molecular clouds that was discovered by Caratti o Garatti et al. to have recently undergone an order-of-magnitude increase in luminosity. Our near-infrared spectra of the source have strong blueshifted He I {lambda}10830 absorption, strong H{sub 2}O and CO absorption, and no H I emission, all typical of FU Orionis sources. With data from the Infrared Telescope Facility, the Two Micron All Sky Survey, the Hubble Space Telescope, Spitzer, the Wide-field Infrared Survey Explorer, Herschel, and the Atacama Pathfinder Experiment that span from 1 to 70 {mu}m pre-outburst and from 1 to 870 {mu}m post-outburst, we estimate that the outburst began between 2005 April and 2007 March. We also model the pre- and post-outburst spectral energy distributions of the source, finding it to be in the late stages of accreting its envelope with a disk-to-star accretion rate that increased from {approx}2 Multiplication-Sign 10{sup -6} M{sub Sun} yr{sup -1} to {approx}10{sup -5} M{sub Sun} yr{sup -1} during the outburst. The post-outburst luminosity at the epoch of the FU Orionis-like near-IR spectra is 28 L{sub Sun }, making V2775 Ori the least luminous documented FU Orionis outburster with a protostellar envelope. The existence of low-luminosity outbursts supports the notion that a range of episiodic accretion phenomena can partially explain the observed spread in protostellar luminosities.

  13. PROF. DR. M. FAHRETTİN KIRZIOĞLU’ NUN BAZI MÜCADELELERİ VE MEKTUPLARINDAN İKTİBASLAR

    OpenAIRE

    Kırzıoğlu, Banıçiçek

    2010-01-01

    ÖZETMakale, Türkolog Prof. Dr. M. Fahrettin Kırzıoğlu’nun , kardeşi M. Cemal Kırzıoğlu’na yazdığı bazı mektuplarından alıntılar ile; bu mektuplardan tespit edilebilen bir kısım mücadelelerini ihtiva etmektedir. ABSTRACTThis study includes some quotations from the letters that a Turcologist Prof. Dr. M.Fahrettin Kırzıoğlu wrote to his brother M. Cemal Kırzıoğlu and some of his contention determined through these letters.

  14. Concurrent chemoradiotherapy with nedaplatin and 5-fluorouracil (5-FU) for locally advanced squamous cell carcinoma of the esophagus

    International Nuclear Information System (INIS)

    Kubo, Naoshi; Morimoto, Junya; Tanaka, Hiroaki

    2009-01-01

    Concurrent chemoradiotherapy (CRT) using cisplatin (CDDP) and 5-fluorouracil (5-FU) is the standard treatment for unresectable locally advanced esophageal carcinoma. Although this regimen has been widely accepted in Japan, the adverse effect of CDDP such as gastrointestinal and renal toxicity may sometimes be the cause of interruption of the treatment, especially among the elderly patients. Cis-diammine-glycolatoplatinum (nedaplatin: CDGP) is a new platinum agent, which was developed with the aim of decreasing renal and gastrointestinal toxicities but maintaining the effectiveness of CDDP. We reported the efficacy and safety of CRT using CDGP and 5-FU for locally advanced squamous cell carcinoma of the esophagus. Between January 2001 and December 2007, 65 patients with locally advanced esophageal cancer (39 patients with unresectable tumor (cT4) and 26 patients with distant lymphnode or bulky lymphnode metastasis) were eligible and given informed consent and cared by the Department of Surgical Oncology of Osaka City University. Patients received a continuous infusion of 5-FU (250 mg/body) on days 1-21. CDGP was administered at the dose of 10 mg/body by bolus infusion for 1 hour on days 1-5, 8-12 and 15-19 just before radiotherapy. Radiotherapy was delivered in 1.8 Gy fractions, 5 days/week for 4 weeks. For the effective cases of CRT, a surgical resection was followed subsequently and an additional radiotherapy at the dose of 20 Gy was performed for non-effective cases. Complete or partial response was achieved in 46 patients (71%). Hematologic toxicities such as grades 3 and 4 leucocytopenia developed in 19 patients and thrombocytopenia developed in 20 patients, which were well tolerated by conservative therapy. Gastrointestinal and renal toxicities were developed in only a few patients. There was no CRT-related death. Of all 65 patients, 25 patients underwent a surgical resection while 19 patients could receive a curative resection (R0 operation). In the resected

  15. Herbal medicine Guan Chang Fu Fang enhances 5-fluorouracil cytotoxicity and affects drug-associated genes in human colorectal carcinoma cells.

    Science.gov (United States)

    Yu, Chen; Liu, Shen-Lin; Qi, Ming-Hao; Zou, Xi; Wu, Jian; Zhang, Jing

    2015-02-01

    Guan Chang Fu Fang (GCFF) is a natural compound, which is extracted from three medicinal plants, Agrimonia pilosa Ledeb ., Patrinia scabiosaefolia and Solanum nigrum L . GCFF has demonstrated clinical efficacy in the treatment of colon cancer. At present, 5-fluorouracil (5-FU) is the primary active chemotherapeutic agent used for treating colon cancer. Using median-effect and apoptosis analyses, fluorescence microscopy and western blotting, the present study analyzed the association between GCFF and 5-FU in the human colon adenocarcinoma LoVo cell line. The effect of GCFF on the expression of chemotherapeutic agent-associated genes was also investigated. The results of the synergistic analysis revealed that GCFF exhibited a significant effect upon 5-FU-associated cytotoxicity within the LoVo cell line. This effect was observed over a broad dose-inhibition range (5-95%), but was particularly significant in the lower concentrations. The flow cytometry results revealed that low doses of GCFF or 5-FU induced S-phase arrest, as did a low-dose combination of the two drugs. After 48 h, GCFF significantly suppressed the expression levels of the chemotherapeutic agent resistance-associated genes within the colon cancer cells. The western blot analysis revealed that the combined effects of 5-FU and GCFF were due to a regulation of the B-cell lymphoma-2 family of proteins. The findings of the present study suggested that GCFF, when combined with 5-FU, has the potential to be a novel, chemotherapeutic compound for the treatment of colon cancer.

  16. Depressive syndromes among female caregivers of schizophrenic patients in prof. dr. m. ildrem mental hospital medan

    Science.gov (United States)

    Handi, A.; Husada, M. S.; Gultom, D. P.

    2018-03-01

    Caring for schizophrenic patients can lead to emotional distress. It remains unclear about the level of depressive syndromes among female caregivers of schizophrenic patients. To determine the level of depression among female caregivers of schizophrenic patients. This is a descriptive study with a cross-sectional approach to describe the level of depression of female caregivers in Prof. dr. M. Ildrem Mental Hospital Medan, using HADS instruments. Most age group of caregivers is from age 51-60 years that is 48.15%, caregiver’s work status mostly not works (62.96%), marital status of caregiver mostly is married (59.26%), kinship with most patients are a biological mother (57.41%). Most patient age group is from age below 30 years (50%), work status of most patients is not working (81.48%), marital status of most caregiver is married (83.33%). Mostly of the depressive syndrome is mild depression (42.59%). Mostly of the depressive syndrome is from mild depression.

  17. Tanggapan Terhadap Kami No Shiten dan Mushi No Shiten No Gengo Bunka dari Prof. Someya Yoshimichi

    Directory of Open Access Journals (Sweden)

    Sheddy N. Tjandra

    2013-04-01

    Full Text Available This is a preliminary study about Japanese conception of the world’s language and culture. Prof. Someya Yoshimichi, emeritus professor from Shizuoka Unversity Japan, in an international conferene on Japanese studies held at Universitas Nasional Jakarta on February 2012, has pointed out that the present world’s language and culture can be divided into two categories. One is God’s Language and Culture, and the other is Insect’s Language a Culture. According to him, the God’s Language and Culture is mainly from European and American (Europe, and the Insect’s Laguage and Culture is mainly from Asian especially from Japan and South-east Asia. The writer does not understand why the Japanese takes God and Insect as a pair of contrastive culture. Therefore, the writer collected data from Indonesian indigenous culture, mainly from public beliefs and religions to argue about the Japanese pair of contrastive culture.  This writing uses qualitative interpretation method (hermeneutics and a method of descriptive analysis to understand Indonesian data, and to present the results of interpretation. For previous studies, the writer took the Japanese and Chinese In-yooron to check the realities of Japanese conception, and also took hipernym and hyponym theory from semantics to check the contrastive meaning of the word God and Insect. In short, the writer sees that God and Insect are not an antonym, and also have no contrastive meaning in any sense of semantics and logics.  

  18. International Studies in Africa. Interview with Prof. O. Igho Natufe, Nigeria

    Directory of Open Access Journals (Sweden)

    Dzherri Roulings Tafotie Deffo Jerry Rowllings

    2016-12-01

    Full Text Available O. Igho Natufe is a Nigerian-born Sovietologist and a specialist in International Relations and Soviet/ Russian Foreign Policy. Dr. Natufe is an alumnus of the People's Friendship University, a former university professor of Political Science (University of Ghana, Accra, Ghana, 1978-1980, and the University of Benin, Benin City, Nigeria, 1980-1989 and senior advisor to the Government of Canada (1970-1978, 1989-2011. He is author of several of scientific research, including “Soviet policy in Africa: from Lenin to Brezhnev”. In his interview he speeks about IR studies in Africa, about mutual perceptions of Russians and Africans, about his recent book on Soviet and Russian Foreign Policy, about scramble for Africa between great and emerging powers. He expects Russia, the USA, and China to enhance their influence in Africa, at the expense of Britain and France. Prof. Natufe pays a special attention to the role of African Diaspora in Development of African countries.

  19. Engineering approaches to transdermal drug delivery: a tribute to contributions of prof. Robert Langer.

    Science.gov (United States)

    Mitragotri, S

    2013-01-01

    Transdermal drug delivery continues to provide an advantageous route of drug administration over injections. While the number of drugs delivered by passive transdermal patches has increased over the years, no macromolecule is currently delivered by the transdermal route. Substantial research efforts have been dedicated by a large number of researchers representing varied disciplines including biology, chemistry, pharmaceutics and engineering to understand, model and overcome the skin's barrier properties. This article focuses on engineering contributions to the field of transdermal drug delivery. The article pays tribute to Prof. Robert Langer, who pioneered the engineering approach towards transdermal drug delivery. Over a period spanning nearly 25 years since his first publication in the field of transdermal drug delivery, Bob Langer has deeply impacted the field by quantitative analysis and innovative engineering. At the same time, he has inspired several generations of engineers by collaborations and mentorship. His scientific insights, innovative technologies, translational efforts and dedicated mentorship have transformed the field. © 2013 S. Karger AG, Basel.

  20. APLIKASI TECHNOLOGY ACCEPTANCE MODEL PADA SISTEM INFORMASI MANAJEMEN RUMAH SAKIT DI RUMAH SAKIT ORTOPEDI PROF. DR. R. SOEHARSO SURAKARTA

    OpenAIRE

    Supriyanti Supriyanti; Muhammad Cholil

    2017-01-01

    The purpose of this study to apply the Technology Acceptance Model (TAM) on the Hospital Management Information System. This research is important because changes in hospital management information system (SIMRS) of the old system in collaboration with third parties to the new system is a standalone system that was developed by the IT team RSO Prof. dr. R. Soeharso requires a process of transition, which for some employees lead to conflict in the process of adaptation. This stu...

  1. Efek Electro Convulsive Therapy (ECT) terhadap Daya Ingat Pasien Skizofrenia di RSJ Prof. HB. Sa’anin Padang

    OpenAIRE

    Ikky Nabila Nandinanti; Yaslinda Yaunin; Siti Nurhajjah

    2015-01-01

    Abstrak  ECT merupakan terapi kejang listrik dengan menghantarkan arus listrik pada elektroda dan dipasang pada kepala sehingga menyebabkan konvulsi. ECT terbukti dapat memperbaiki gejala skizofrenia, namun ECT juga memiliki efek samping terutama pada daya ingat. Tujuan  penelitian ini adalah mengetahui efek ECT terhadap daya ingat pasien skizofrenia. Metode : Penelitian ini menggunakan desain analitik dengan jumlah sampel 15 orang penderita skizofrenia di Rumah Sakit Jiwa (RSJ) Prof. HB. Sa’...

  2. PROF-DD, Generator of Multigroup Cross-Sections Library DDX for MORSE-DD, ANISN-DD, DOT-DD

    International Nuclear Information System (INIS)

    Mori, Takamasa; Nakagawa, Masayuki; Ishiguro, Yukio

    2002-01-01

    1 - Description of program or function: The code system PROF-DD generates a multi-group double-differential cross section library DDX from evaluated data in ENDF/B-IV or ENDF/B-V format. The system consists of the following five modules: PROF-DDX is the main module of the system. It calculates the multigroup DDX and stores them on a master PDS file. MCFILEF generates a control file for PROF-DDX, which contains energy group and angle bin structures. SPINPTF prepares an input data file for PROF-DDX by combining the control file with other input data. DDXLIBMK edits a DDX library from the master PDS file for transport calculations. RESENDD performs resonance cross section and Doppler broadening calculations. 2 - Restrictions on the complexity of the problem: The numbers of energy groups and angle bins are less than 150 and 40, respectively

  3. [A case of advanced gastric cancer with carcinomatosa peritonitis effectively treated by 5-FU and low-dose CDDP therapy].

    Science.gov (United States)

    Saito, E; Kunii, Y; Wada, G; Tsuchiya, S; Yamasaki, T; Sakakibara, N

    1997-07-01

    A 66-year-old woman was admitted to our clinic for appetite loss and abdominal distension in August 1995. Endoscopic study revealed an advanced gastric cancer in the upper body of her stomach. Abdominal CT study revealed massive ascites and para-aortic lymph nodal involvement. Cytological study of the ascites revealed class V. She was diagnosed to be in the terminal stage of gastric cancer with carcinomatosa peritonitis. Combination chemotherapy with 5-fluorouracil (5-FU) and low-dose cisplatin (CDDP) was given by continuous intravenous injection of 5-FU 500 mg/day, and intermittent intravenous injection of CDDP 30 mg/week was performed for reduction of the ascites and her complaint. Endoscopic study 6 weeks after starting chemotherapy could not find crater of the gastric cancer but only a shallow ulcerative lesion. The biopsy specimen of that lesion was group III. No ascites and over 50% reduction of the para-aortic lymph node were found by the abdominal CT study. This state persisted over 4 weeks. No myelo-suppression, renal dysfunction or any severe side effect were observed during chemotherapy. Her performance status improved from 3 to 1.

  4. Investigation on biochemical compositional changes during the microbial fermentation process of Fu brick tea by LC-MS based metabolomics.

    Science.gov (United States)

    Xu, Jie; Hu, Feng-Lin; Wang, Wei; Wan, Xiao-Chun; Bao, Guan-Hu

    2015-11-01

    Fu brick tea (FBT) is a unique post-fermented tea product which is fermented with fungi during the manufacturing process. In this study, we investigated the biochemical compositional changes occurring during the microbial fermentation process (MFP) of FBT based on non-targeted LC-MS, which was a comprehensive and unbiased methodology. Our data analysis took a two-phase approach: (1) comparison of FBT with other tea products using PCA analysis to exhibit the characteristic effect of MFP on the formation of Fu brick tea and (2) comparison of tea samples throughout the MFP of FBT to elucidate the possible key metabolic pathways produced by the fungi. Non-targeted LC-MS analysis clearly distinguished FBT with other tea samples and highlighted some interesting metabolic pathways during the MFP including B ring fission catechin. Our study demonstrated that those fungi had a significant influence on the biochemical profiles in the FBT and consequently contributed to its unique quality. Copyright © 2014 Elsevier Ltd. All rights reserved.

  5. [Knockdown of DNA-PKcs inhibits cell cycle and its mechanism of drug-resistant Bel7402/5-Fu hepatocellular carcinoma cells].

    Science.gov (United States)

    Li, Dayu; Liu, Yun; Yu, Chunbo; Liu, Xiping; Fan, Fang

    2017-12-01

    Objective To study the effect of the knock-down of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) on the cell cycle of the multidrug-resistant (MDR) Bel7402/5-Fu hepatocellular carcinoma cells and its MDR mechanism. Methods After cationic liposome-mediated siDNA-PKcs oligonucleotide transfection, the drug sensitivity of Bel7402/5-Fu cells to 5-fluorouracil (5-Fu) and adriamycin (ADM) was determined by MTT assay; the cell cycle were detected by flow cytometry; meanwhile, the protein expressions of cell cycle-related proteins P21, cell cycle protein B1 (cyclin B1), cell cycle division protein 2 (CDC2) were tested by Western blotting; the expressions of ataxia telangiectasia mutated (ATM) and p53 at both mRNA and protein levels were detected by real-time PCR and Western blot analysis. Results The MTT results showed siDNA-PKcs increased the chemotherapeutic sensitivity of Bel7402/5-Fu cells to 5-Fu and ADM. The flow cytometric analysis showed siDNA-PKcs decreased the percentage of S-phase cells but increased the percentage of G2/M phase cells. Western blotting showed siDNA-PKcs increased the protein expression of P21 but decreased cyclinB1 and CDC2 proteins. In addition, siDNA-PKcs also increased the expressions of ATM and p53. Conclusion DNA-PKcs silencing increases P21 while decreases cyclin B1 and CDC2 expressions, and finally induces G2/M phase arrest in Bel7402/5-Fu cells, which may be related to ATM-p53 signaling pathway.

  6. THE MAN HAD LINGUISTICS LIKED: PROF. DR. DOĞAN AKSAN DİL BİLİMİNİ SEVDİREN ADAM: PROF. DR. DOĞAN AKSAN (1929-2010

    Directory of Open Access Journals (Sweden)

    Ahmet Turan SİNAN

    2010-10-01

    Full Text Available Who is the linguistics studies’ the one of innovators in Turkey, Prof. Dr. Doğan Aksan is very important scientist who fall in love with Turkish, reweal the richness and power of expression of our mother tangue. He displays a lot of European turcologits’ delussions as A. von Gabain, R. Giraud, J. Kramsky for Turkish with his studies. Aksan, who writes a lot of studies for shabbiness, semantic features, expression, flexibility of Turkish, Turkish education, takes place between founders of linguistic in Turkey. He displays the big love to Turkish by serving to Turkish in the light of the methods and techniques of universal linguistic. Prof. Dr. Doğan Aksan will be remember always as a very important scientist and the man had linguistics liked. Türkiye’deki dil bilim çalışmalarının öncülerinden olan Prof. Dr. Doğan Aksan; Türkçeye gönül vermiş, anlam bilim çalışmaları ile ana dilimizin zenginliğini ve anlatım gücünü gözler önüne seren çok önemli bir bilim adamıdır. Bu çalışmaları ile A. von Gabain, R. Giraud, J. Kramsky gibi birçok Avrupalı Türkologun Türkçeye yönelik yanılgılarını da ortaya koymuştur. Türkçenin eskiliğine, anlamsal özelliklerine, anlatım gücü ve esnekliğine, Türkçe öğretimine yönelik birçok esere imza atan Aksan, Türkiye’de dil bilimin kurucuları arasında yer alır. Türkçeye olan büyük sevgisini evrensel dil bilimin yöntem ve teknikleri ışığında hizmet ederek göstermiştir. Prof. Dr. Doğan Aksan, çok önemli bir bilim adamı ve her şeyden önce dil bilimi sevdiren kişi olarak daima hatırlanacaktır.

  7. Prof Dr Zeki Soysal’a Saygı İle

    Directory of Open Access Journals (Sweden)

    Sermet Koç

    2006-12-01

    oğunu gece yarılarına kadar, odasında asistanları ile kitap yazarak geçirmeye devam etmişti. Ömrünün son günlerinde camiamızda yaşanılan ayrılıklardan, sorunlardan dolayı da çok üzgündü. Camiamızda fırtına koparılan o puslu günlerde kendisine gelerek ATUD’dan ayrılmasını isteyenleri bir türlü anlamadığını, sık sık hayıflandığını hatırlıyorum. Hele Adli Tıp Kurumu’nun eski kendi mekanından aniden taşınma kararına hiç anlam verememişti ve yaşanılan gelişmelerin pek hayra olmadığını ifade etmişti. Onu yitirdiğimizde, çok yalnız kaldığımızı hissettim, ama herkes adına, tüm camia adına. Anabilim dalımız, ondan sonraki ilk akademik kurul toplantısında, odasına “Prof. Dr. Zeki Soysal Çalışma Odası ve Kitaplığı" adını verme kararını aldı ve bu öneri üniversite yönetiminin 20.06.2006 tarih 27036 sayılı kararı ile kabul edildi. Belki bir gün, kapısını açar, konuklarını kabul ederiz; çay kahve ikram ederiz, el yazısı çalışmalarından birkaç sayfa sunarız; yani beraber olmanın, birlikte olmanın güzelliğini belki hatırlarız,., diyedir. Belki de, bir gün “Prof. Dr. Zeki Soysal Adli Obstetrik ve Jinekoloji Günleri” diye başlayacak olan günlerde oda ziyaretleri yaparız, kim bilir? Şu ‘gri’ anımı yazmadan geçemeyeceğim: Zeki Abi’nin, özellikle vasiyetinde de belirttiği gibi “en güzel günlerinde” zevkle yaptığı eğitim otopsilerinin, bir çok asistan ve öğrencinin yetişmesinde büyük payı vardır. Kendisi, bu en az üç dört saat süren otopsi seanslarında; hem cerrah, hem de adli tıpçı olmasının verdiği hünerle olsa gerek; bir “otopsi virtüözü” gibi sanatını icra ederdi. Bu nedenle, o acımasız hastalığa tutulduğu ve ümitlerimizi büyük ölçüde yitirdiğimiz günlerde. Kurum Başkanı’nı ziyaret ederek. Otopsi Salonu’na adının verilmesini önermiştim, ... , şimdi ne yazık ki kapışma kilit vurulan bu

  8. Professor Paul Crutzen, the winner of the Nobel prize: The discovery of the ozone hole - knowledge and vision; Nobelpreistraeger Prof. Paul Crutzen: Entdeckung des Ozonlochs - Wissen und Vision

    Energy Technology Data Exchange (ETDEWEB)

    Crutzen, P.; Dellert-Ritter, M.

    1997-02-01

    On 10 December 1995, Professor Crutzen was awarded the Nobel prize for his epoch-making achievements in the field of atmospheric chemistry. This award underlines also Professor Crutzen`s commitment to the protection of the atmosphere. The atmospheric researcher discovered how sensitively the ozone layer reacts to air pollution. His work, together with that of others, led to the ban on ozone-depleting chlorofluorocarbons. As early as in 1970, Professor Crutzen demonstrated that nitrogen oxides react catalytically with ozone. His think tank provided numerous stimuli for further, intense research on atmospheric chemistry, which triggered a debate on the protection of the thinning ozone layer also among politicians. (orig.) [Deutsch] Am 10. Dezember 1995 wurde Prof. Crutzen fuer seine bahnbrechenden Leistungen auf dem Gebiet der Atmosphaerenchemie mit dem Nobelpreis geehrt. Diese Anerkennung unterstreicht auch das Engagement von Prof. Crutzen zum Schutz der Ozonschicht. Der Atmosphaerenforscher Prof. Crutzen entdeckte, wie empfindlich die Ozonschicht auf Luftverunreinigungen reagiert. Seine Arbeiten fuehrten mit zum Verbot der ozonvernichtenden Fluorchlorkohlenwasserstoffe. Bereits 1970 wies Prof. Crutzen nach, dass Stickstoffoxide katalytisch mit Ozon reagieren. Aus der Ideenfabrik von Prof. Crutzen kamen zahlreiche Anregungen fuer weitere intensive Forschungen zur Chemie der Atmosphaere, die auch unter Politikern eine Debatte ueber den Schutz der hauchduennen Ozonschicht ausloeste. (orig.)

  9. Non-viral genetic transfection of rat Schwann cells with FuGENE HD© lipofection and AMAXA© nucleofection is feasible but impairs cell viability.

    Science.gov (United States)

    Kraus, Armin; Täger, Joachim; Kohler, Konrad; Haerle, Max; Werdin, Frank; Schaller, Hans-Eberhard; Sinis, Nektarios

    2010-11-01

    To determine transfection efficiency of FuGENE HD© lipofection and AMAXA© nucleofection on rat Schwann cells (SC). The ischiadic and median nerves of 6-8 week old Lewis rats were cultured in modified melanocyte-growth medium. SCs were genetically transfected with green fluorescent protein (GFP) as reporter gene using FuGENE HD© lipofection and AMAXA© nucleofection. Transfection rates were determined by visualization of GFP fluorescence under fluorescence microscopy and cell counting. Transfected cell to non-transfected cell relation was determined. Purity of Schwann cell culture was 88% as determined by immunohistologic staining. Transfection rate of FuGENE HD© lipofection was 2%, transfection rate of AMAXA© nucleofection was 10%. With both methods, Schwann cells showed pronounced aggregation behavior which made them unfeasible for further cultivation. Settling of Schwann cells on laminin and poly-L-ornithine coated plates was compromised by either method. Non-viral transfection of rat SC with FuGENE HD© lipofection and AMAXA© nucleofection is basically possible with a higher transfection rate for nucleofection than for lipofection. As cell viability is compromised by either method however, viral transfection is to be considered if higher efficiency is required.

  10. Expression and Role of Oct3/4 in Injury-Repair Process of Rat Alveolar Epithelium after 5-Fu Treatment

    Directory of Open Access Journals (Sweden)

    Wen-ya Li

    2017-01-01

    Full Text Available Objective. We aimed to investigate how the embryonic stem cell-related gene Oct3/4 changes during the injury-repair process of distal pulmonary epithelium induced by 5-fluorouracil (5-Fu. Methods. We have developed the lung injury model induced by 5-Fu and observed the dynamic changes of Oct3/4 by indirect immunofluorescence, Western blot, and quantitative real-time PCR. Immunofluorescence double staining was used to compare the positions of Oct3/4(+ cells and other reported alveolar epithelial stem cells. Results. Oct3/4(+ cells were not found in normal rat lung epithelial cells. However, after treatment with 5-Fu, Oct3/4(+ cells appeared at 12 h, reached the peak at 24 h, then decreased at 48 h, and eventually disappeared at 72 h. Oct3/4 was localized in the nucleus. We found that the sites of Clara cell secretory protein and surfactant protein-C dual positive cells were apparently different from Oct3/4(+ cells. Conclusions. Our results revealed that, in rat alveolar epithelium, expression of Oct3/4 could be induced after treatment with 5-Fu, then decreased gradually, and was silenced following the alveolar epithelial differentiation. We hold that Oct3/4(+ cells are lung stem cells, which can provide new evidence for identification and isolation of lung epithelial stem cells.

  11. Prof.Dr. Ahmed Yüksel Özemre’nin Tasavvufî Görüşleri

    OpenAIRE

    KALKAN, Bilgihan

    2015-01-01

    Prof. Dr. Ahmed Yüksel Özemre(1935-2008), Türkiye’nin ilk atom mühendisiolmasının yanı sıra Türkiye Atom Enerjisi (TAE) Kurumundaki görevidolayısı ile ülkemizin tanınmış ilim adamlarındandır. Bu makalede Prof. Dr. AhmedYüksel Özemre’nin daha az bilinen ve çocukluk çağlarında tasavvufî muhitlerile yakın temas halinde bulunması ile başlayan ve zaman içerisinde yalnızcaentelektüel bir uğraş olmanın ötesine geçerek, yaşam şekline dönüşen tasavvufîhayatı ve genel hatları ile İslâm tasavvufu hakkın...

  12. [Effects of intravenous alimentation on adjuvant chemotherapy--an experimental study on the distribution of 5-FU after injection of tegafur (2)].

    Science.gov (United States)

    Kimoto, M; Nagano, H; Sano, K

    1987-10-01

    The stomach, small and large intestines, heart, lungs, bone and kidneys were removed from 48 Sato lung cancer-bearing rats used in the previous experiments and given 90 mg/kg of tegafur (FT-207) by single intravenous administration and tissue 5-FU and FT-207 concentrations were measured. FT-207 concentration in the alimentary canal was somewhat lower than the blood concentration, but both were lowered in parallel. 5-FU concentration in the stomach and large intestines showed virtually identical changes in both IVH and PO groups, but IVH group tended to have higher concentration. IVH group showed higher values than PO group anytime, particularly in the large intestines. A reduction of the side effects on the digestive system via intravenous alimentation was thought due to the elimination of mechanical stimulation via a cessation of oral feeding. 5-FU concentration in the bone was highest in PO group at six hours after administration and blood concentration changes were parallel, but there was virtually no change in IVH group. Maximum values were found one hour after administration and slowly declined thereafter; at 24 hrs the values were 0.059 +/- 0.013 microgram/g, relatively high compared to the PO group at 0.041 +/- 0.022 microgram/g. In the present study under intravenous alimentation, the concentration changes were slight in spite of 5-FU maximum concentration being lower than that by oral feeding and the long-term high concentration which was maintained; this is thought to be a disadvantageous action with regard to the bone marrow. FT-207 concentration in the kidney, heart and lungs was the same as that for the blood, with a gradual reduction in IVH group. 5-FU concentration was the same for the kidneys and IVH group quickly reached to the high levels compared to PO group with only slight changes thereafter. Effects of continuous water load might be involved but not clear.

  13. Regorafenib with a fluoropyrimidine for metastatic colorectal cancer after progression on multiple 5-FU-containing combination therapies and regorafenib monotherapy.

    Science.gov (United States)

    Marks, Eric I; Tan, Carlyn; Zhang, Jun; Zhou, Lanlan; Yang, Zhaohai; Scicchitano, Angelique; El-Deiry, Wafik S

    2015-01-01

    We present 2 patients with metastatic colorectal cancer who had progressed despite treatment with first-line FOLFOX and second-line FOLFIRI combination chemotherapy regimens. After failing these fluoropyrimidine-based regimens, both patients received additional cytotoxic and targeted therapies with eventual disease progression. These therapies included capecitabine plus dabrafenib and trametinib, regorafenib monotherapy, and regorafenib with panitumumab. After exhausting available options, both patients were offered regorafenib with either 5-fluorouracil (5-FU) or capecitabine. These therapies are individually approved for the treatment of colorectal cancer but have not yet been studied in combination. This regimen produced stable disease in both patients with acceptable toxicity. One patient continued therapy for 17 months. Although these patients previously progressed during treatment with regorafenib, capecitabine or 5-FU, the combination had some activity in both cases of refractory metastatic colorectal cancer and may be considered in the palliative setting. In bedside-to-bench cell culture experiments performed after the clinical observations, we observed sensitivity of human colorectal cancer cell lines (N = 4) to single agent regorafenib or 5-FU and evidence of synergy with the combination therapy. Synergistic effects were noted in colorectal cancer cells with KRAS mutation, BRAF mutation, and p53 mutation, as well as mismatch repair deficient cells. Regorafenib suppressed Mcl-1 and Bcl-XL in treated cancer cells that may have contributed to the anticancer efficacy including in combination with 5-FU. The safety and efficacy of regorafenib with 5-FU or capecitabine in combination should be further investigated as a therapy for patients with refractory metastatic colorectal cancer, including individuals who had progressed on regorafenib monotherapy.

  14. Combined 5-FU and ChoKα inhibitors as a new alternative therapy of colorectal cancer: evidence in human tumor-derived cell lines and mouse xenografts.

    Directory of Open Access Journals (Sweden)

    Ana de la Cueva

    Full Text Available Colorectal cancer (CRC is the third major cause of cancer related deaths in the world. 5-fluorouracil (5-FU is widely used for the treatment of colorectal cancer but as a single-agent renders low response rates. Choline kinase alpha (ChoKα, an enzyme that plays a role in cell proliferation and transformation, has been reported overexpressed in many different tumors, including colorectal tumors. ChoKα inhibitors have recently entered clinical trials as a novel antitumor strategy.ChoKα specific inhibitors, MN58b and TCD-717, have demonstrated a potent antitumoral activity both in vitro and in vivo against several tumor-derived cell line xenografts including CRC-derived cell lines. The effect of ChoKα inhibitors in combination with 5-FU as a new alternative for the treatment of colon tumors has been investigated both in vitro in CRC-tumour derived cell lines, and in vivo in mouse xenografts models. The effects on thymidilate synthase (TS and thymidine kinase (TK1 levels, two enzymes known to play an essential role in the mechanism of action of 5-FU, were analyzed by western blotting and quantitative PCR analysis. The combination of 5-FU with ChoKα inhibitors resulted in a synergistic effect in vitro in three different human colon cancer cell lines, and in vivo against human colon xenografts in nude mice. ChoKα inhibitors modulate the expression levels of TS and TK1 through inhibition of E2F production, providing a rational for its mechanism of action.Our data suggest that both drugs in combination display a synergistic antitumoral effect due to ChoKα inhibitors-driven modulation of the metabolization of 5-FU. The clinical relevance of these findings is strongly supported since TCD-717 has recently entered Phase I clinical trials against solid tumors.

  15. The Many Sides of Happy Lim: aka Hom Ah Wing, Lin Jian Fu, Happy Lum, Lin Chien Fu, Hom Yen Chuck, Lam Kin Foo, Lum Kin Foo, Hom, Lim Goon Wing, Lim Gin Foo, Gin Foo Lin, Koon Wing Lim, Henry Chin, Lim Ying Chuck, Lim Ah Wing, et. al.

    Directory of Open Access Journals (Sweden)

    Gordon H. Chang

    2010-03-01

    Full Text Available

    Known to the FBI, INS, and IRS as Mr. Ah Wing Hom, he was also Lin Jian Fu, Jian Fu (Tough Guy, or just Fu to the readers of the many poems and short stories he published in Chinese over four decades in the twentieth century. And to still others, primarily English-readers of his writing, he was Happy Lim, an ironic, even tragically bizarre name, as his life was far from pleasant. On New Year's Day 1986, he died alone in a dingy San Francisco Chinatown bachelor hotel suffering from a bacterial infection and a chronic blood disorder that had required the amputation of all his toes the year before. He was seventy-eight years of age and had spent most of his life within blocks of where he died.

  16. «A Ca’ Giustinian fu tutto diverso». La mostra di Paolo Veronese a Venezia (1939 / «A Ca’ Giustinian fu tutto diverso» (At Ca’ Giustiniani eveything was different. Paolo Veronese exhibition in Venice (1939

    Directory of Open Access Journals (Sweden)

    Matilde Cartolari

    2016-12-01

    Full Text Available La mostra di Paolo Veronese si svolse a Venezia nel 1939 sotto la direzione di Rodolfo Pallucchini. Promuovendo una ricognizione materiale e critica dell’opera del maestro, la mostra fu l’occasione per effettuare una massiccia campagna di restauri ad opera del bergamasco Mauro Pellicioli e della sua squadra di collaboratori. Agendo sul duplice fronte della museografia e del restauro, Pallucchini si pose in dialogo con le parallele definizioni elaborate in sede istituzionale da Guglielmo Pacchioni e Giulio Carlo Argan. Il presente saggio intende offrire, attraverso materiale archivistico inedito, un’analisi del ruolo della mostra di Veronese nel contesto nazionale e internazionale, ricostruendo con un approccio interdisciplinare le dinamiche teoriche e operative che ne animarono lo svolgimento. Veronese exhibition took place in Venice in 1939 under the direction of Rodolfo Pallucchini. While promoting both material and critical examination of Veronese’s work, the exhibition was an opportunity to undertake a massive restoration, performed by Mauro Pellicioli and his team of collaborators. Pallucchini’s museographical and conservative program was in close relation with the theories promoted by Guglielmo Pacchioni and Giulio Carlo Argan in public administration. This paper intends to offer, through unpublished archival evidence, a detailed analysis of Veronese exhibition in relation to national and international context, in order to understand with an interdisciplinary approach both its theoretical and practical aspects.

  17. Long-term results of the maxillary sinus carcinoma with irradiation and intraarterial infusion of 5-FU

    Energy Technology Data Exchange (ETDEWEB)

    Sakaguchi, Masanori; Netsu, Kiminori (Shinshu Univ., Matsumoto, Nagano (Japan). Faculty of Medicine); Kawarada, Kazuo; Yachiyama, Hitoshi

    1990-08-01

    Therapeutic results of 33 primary cases of maxillary sinus carcinoma treated with irradiation and intraarterial infusion of 5-FU between 1972 and 1984 were analyzed. The 5-year crude survival rate for the group with stage T2 carcinoma (n=10) was 50.0%, and for those with T3 (n=15) and T4 (n=8) it was 46.7% and 25.0%, respectively. The overall 5-year crude survival rate was 42.4%. Eight patients who did not undergo maxillectomy survived for 5 years after irradiation and intraarterial infusion. Recurrence of the tumor after the irradiation and intraarterial infusion occurred in 63.6%, and was frequently observed at the ethmoidal region and the orbita. In the areas in which the tumor extended to regions such as the ethmoid sinus and orbita, which are nourished by arteries other than the maxillary artery, conventional intraarterial infusion was ineffective for complete tumor eradication. Therefore, in most of the patients with advanced maxillary sinus carcinoma, partial or total maxillectomy following combined therapy of intraarterial infusion and irradiation is necessary to improve a prognosis. (author).

  18. VARIABILITY AT THE EDGE: OPTICAL NEAR/IR RAPID-CADENCE MONITORING OF NEWLY OUTBURSTING FU ORIONIS OBJECT HBC 722

    International Nuclear Information System (INIS)

    Green, Joel D.; Robertson, Paul; Pak, Soojong; Meschiari, Stefano; Baek, Giseon; Lee, Jeong-Eun; Pooley, David; Im, Myungshin; Jeon, Yiseul; Choi, Changsu

    2013-01-01

    We present the detection of day-timescale periodic variability in the r-band lightcurve of newly outbursting FU Orionis-type object HBC 722, taken from >42 nights of observation with the CQUEAN instrument on the McDonald Observatory 2.1 m telescope. The optical/near-IR lightcurve of HBC 722 shows a complex array of periodic variability, clustering around 5.8-day (0.044 mag amplitude) and 1.28-day (0.016 mag amplitude) periods, after removal of overall baseline variation. We attribute the unusual number of comparable strength signals to a phenomenon related to the temporary increase in accretion rate associated with FUors. We consider semi-random 'flickering', magnetic braking/field compression and rotational asymmetries in the disk instability region as potential sources of variability. Assuming that the 5.8-day period is due to stellar rotation and the 1.28-day period is indicative of Keplerian rotation at the inner radius of the accretion disk (at 2 R * ), we derive a B-field strength of 2.2-2.7 kG, slightly larger than typical T Tauri stars. If instead the 5.8-day signal is from a disk asymmetry, the instability region has an outer radius of 5.4 R * , consistent with models of FUor disks. Further exploration of the time domain in this complicated source and related objects will be key to understanding accretion processes.

  19. Technical note: Fu-Liou-Gu and Corti-Peter model performance evaluation for radiative retrievals from cirrus clouds

    Science.gov (United States)

    Lolli, Simone; Campbell, James R.; Lewis, Jasper R.; Gu, Yu; Welton, Ellsworth J.

    2017-06-01

    We compare, for the first time, the performance of a simplified atmospheric radiative transfer algorithm package, the Corti-Peter (CP) model, versus the more complex Fu-Liou-Gu (FLG) model, for resolving top-of-the-atmosphere radiative forcing characteristics from single-layer cirrus clouds obtained from the NASA Micro-Pulse Lidar Network database in 2010 and 2011 at Singapore and in Greenbelt, Maryland, USA, in 2012. Specifically, CP simplifies calculation of both clear-sky longwave and shortwave radiation through regression analysis applied to radiative calculations, which contributes significantly to differences between the two. The results of the intercomparison show that differences in annual net top-of-the-atmosphere (TOA) cloud radiative forcing can reach 65 %. This is particularly true when land surface temperatures are warmer than 288 K, where the CP regression analysis becomes less accurate. CP proves useful for first-order estimates of TOA cirrus cloud forcing, but may not be suitable for quantitative accuracy, including the absolute sign of cirrus cloud daytime TOA forcing that can readily oscillate around zero globally.

  20. Gauge-theoretic invariants for topological insulators: a bridge between Berry, Wess-Zumino, and Fu-Kane-Mele

    Science.gov (United States)

    Monaco, Domenico; Tauber, Clément

    2017-07-01

    We establish a connection between two recently proposed approaches to the understanding of the geometric origin of the Fu-Kane-Mele invariant FKM\\in Z_2, arising in the context of two-dimensional time-reversal symmetric topological insulators. On the one hand, the Z_2 invariant can be formulated in terms of the Berry connection and the Berry curvature of the Bloch bundle of occupied states over the Brillouin torus. On the other, using techniques from the theory of bundle gerbes, it is possible to provide an expression for FKM containing the square root of the Wess-Zumino amplitude for a certain U( N)-valued field over the Brillouin torus. We link the two formulas by showing directly the equality between the above-mentioned Wess-Zumino amplitude and the Berry phase, as well as between their square roots. An essential tool of independent interest is an equivariant version of the adjoint Polyakov-Wiegmann formula for fields T^2 → U(N), of which we provide a proof employing only basic homotopy theory and circumventing the language of bundle gerbes.

  1. A randomized controlled trial of Kung Fu training for metabolic health in overweight/obese adolescents: the "martial fitness" study.

    Science.gov (United States)

    Tsang, Tracey W; Kohn, Michael; Chow, Chin Moi; Singh, Maria Fiatarone

    2009-07-01

    Twenty overweight/obese adolescents underwent six months of Kung Fu or placebo (Tai Chi) training, 3x.wk(-1). Outcomes included fasting insulin and insulin resistance, lipids, glucose and HbA(1c), and C-reactive protein (CRP). CRP decreased significantly (p = 0.03) in both groups over time at six months. Although insulin sensitivity did not change, HbA(1c) tended to decrease over time (p = 0.09), again with no group difference (p = 0.60). Reduced CRP was related to increased upper body strength (p = 0.01). Increased lean body mass was related to reductions in HbA(1c), insulin resistance, triglycerides, and total cholesterol. Improvements in lean body mass appear to have a potential role in favorable metabolic outcomes, independent of changes in fat mass. Further research in this area is warranted before definite conclusions can be drawn about the efficacy of martial arts training for metabolic outcomes in this cohort.

  2. Kung Fu Training Improves Physical Fitness Measures in Overweight/Obese Adolescents: The “Martial Fitness” Study

    Directory of Open Access Journals (Sweden)

    Tracey W. Tsang

    2010-01-01

    Full Text Available Aim. To examine the efficacy of a six-month Kung Fu (KF program on physical fitness in overweight/obese adolescents. Methods. Subjects were randomly assigned to the KF or sham exercise (Tai Chi, TC control group. Physical measurements in cardiovascular fitness and muscle fitness occurred at baseline and after 6 months of training thrice weekly. Results. Twenty subjects were recruited. One subject was lost to follow-up, although overall compliance to the training sessions was 46.7±27.8%. At follow-up, the cohort improved in absolute upper (P=.002 and lower (P=.04 body strength, and upper body muscle endurance (P=.02, without group differences. KF training resulted in significantly greater improvements in submaximal cardiovascular fitness (P=.03, lower body muscle endurance (P=.28; significant 95% CI: 0.37–2.49, and upper body muscle velocity (P=.03 relative to TC training. Conclusions. This short-term KF program improved submaximal cardiovascular fitness, lower body muscle endurance, and muscle velocity, in overweight/obese adolescents with very low baseline fitness.

  3. I Am the Invincible Sword Goddess: Mediatization of Chinese Gender Ideology through Female Kung-Fu Practitioners in Films

    Directory of Open Access Journals (Sweden)

    Mie Hiramoto

    2014-09-01

    Full Text Available The media are avid portrayers of gender binarism and the belief in male-female distinctions, which are mainly attributed to perceived differences of a physical nature. In this paper, we investigate representations of female kung-fu practitioners (nuxia in films to discuss how processes of mediation and mediatization depict their femininity, so as to mitigate their appropriation of Chinese martial arts masculinity. Often, nuxias are portrayed as empowered women who are equipped to take control of their own lives and to courageously take on challenges from a variety of opponents. However, multimodal deconstruction of the various characteristics of nuxias must be placed in an Asian-specific context in order to understand the femininity specific to these characters and to move beyond Western gender ideologies displayed by the media. Perpetuating Confucian patriarchal ideals, nuxia roles constantly and consistently associate conformation to Confucian values with virtuousness and non-conformation with wickedness. We therefore can use the ideals of Confucianism as a more accurate foundation in deconstructing the identities of nuxias, which allows us to better understand the mediation and mediatization processes of ideologies associated with Chinese femininity and masculinity in martial arts films.

  4. Long-term results of the maxillary sinus carcinoma with irradiation and intraarterial infusion of 5-FU

    International Nuclear Information System (INIS)

    Sakaguchi, Masanori; Netsu, Kiminori; Kawarada, Kazuo; Yachiyama, Hitoshi.

    1990-01-01

    Therapeutic results of 33 primary cases of maxillary sinus carcinoma treated with irradiation and intraarterial infusion of 5-FU between 1972 and 1984 were analyzed. The 5-year crude survival rate for the group with stage T2 carcinoma (n=10) was 50.0%, and for those with T3 (n=15) and T4 (n=8) it was 46.7% and 25.0%, respectively. The overall 5-year crude survival rate was 42.4%. Eight patients who did not undergo maxillectomy survived for 5 years after irradiation and intraarterial infusion. Recurrence of the tumor after the irradiation and intraarterial infusion occurred in 63.6%, and was frequently observed at the ethmoidal region and the orbita. In the areas in which the tumor extended to regions such as the ethmoid sinus and orbita, which are nourished by arteries other than the maxillary artery, conventional intraarterial infusion was ineffective for complete tumor eradication. Therefore, in most of the patients with advanced maxillary sinus carcinoma, partial or total maxillectomy following combined therapy of intraarterial infusion and irradiation is necessary to improve a prognosis. (author)

  5. ELECTROMYOGRAPHIC STUDY OF A SEQUENCE OF YAU-MAN KUNG FU PALM STRIKES WITH AND WITHOUT IMPACT

    Directory of Open Access Journals (Sweden)

    Osmar Pinto Neto

    2007-10-01

    Full Text Available In martial arts and contact sports, strikes are often trained in two different ways: with and without impacts. This study aims to compare the electromyographical activity (EMG of the triceps brachii (TB, biceps brachii (BB and brachioradialis (BR muscles during strikes with and without impacts. Eight Yau-Man Kung Fu practitioners participated in the experiment. Each participant performed 5 sequences of 5 consecutive KF Yau-Man palm strikes with no impact intercalated with 5 sequences of 5 repetitions targeting a KF training shield. Surface EMG signals were obtained from the TB, BB, and RB for 3.0 seconds using an eight-channel module with a total amplifier gain of 2000 and sampled at 3500 Hz. The EMG analyses were done in the time (rms and frequency (wavelet domains. For the frequency domain, Morlet wavelet power spectra were obtained and an original method was used to quantify statistically significant regions on the power spectra. The results both in the time and frequency domains indicate a higher TB and BR muscle activity for the strikes with impacts. No significant difference was found for the BB in the two different scenarios. In addition, the results show that the wavelet power spectra pattern for the three analysed muscles obtained from the strikes with and without impacts were similar

  6. Psychometric analysis of the Scale of Teacher´s Perception of School Adjustment (PROF-A

    Directory of Open Access Journals (Sweden)

    María-Jesús Cava

    2015-08-01

    Full Text Available Teacher' perception of their students' school adjustment can be an important indicator of psychosocialwell-being and provide useful information for the development of interventions to improve theirpsychosocial adjustment. This is the reason why it is essential within the school adjustment to consider notonly students' academic achievement but also their level of social integration in the classroom, the qualityof their relationship with the teacher, and the level of family involvement in their education. The objectiveof this research is to provide a reliable instrument for measuring a full school adjustment and analyze itsrelationship with two important indicators of psychosocial adjustment, self-concept and attitudes towardauthority. This study involved 87 teachers who assessed the school adjustment of students (N = 2378adolescents using the PROF-A scale. Findings show that this scale consists of four factors, social integration,academic competence, family involvement, and teacher-student relationship, showing significant positivecorrelations with self-concept and positive attitudes toward authority.

  7. Prof.Ing. Vladimír Mareček, DrSc. se potká se pětašedesátkou

    Czech Academy of Sciences Publication Activity Database

    Samec, Zdeněk; Štulík, K.

    2009-01-01

    Roč. 103, č. 10 (2009), s. 867-867 ISSN 0009-2770 Institutional research plan: CEZ:AV0Z40400503 Keywords : Prof. Mareček * electrochemistry Subject RIV: CG - Electrochemistry Impact factor: 0.717, year: 2009

  8. PENGARUH GAYA KEPEMIMPINAN TRANSFORMASIONAL PADA KOMITMEN, KEPUASAN KERJA DAN NIAT PINDAH KERJA DENGAN PERAN MEDIASI KEADILAN DAN KEPERCAYAAN DI RSO PROF. DR. R. SOEHARSO SURAKARTA

    Directory of Open Access Journals (Sweden)

    Paryanto Paryanto

    2017-04-01

    Full Text Available Improving the quality of hospital services can not be separated from the role of the various disciplines of health workers in hospitals, including nurses, because most hospital services are nursing services. The purpose of this study was to analyze the effect of transformational leadership style on commitment, job satisfaction and nurses’ intent to move RSO Prof. Dr. R. Soeharso Surakarta with the mediating role of justice and trust. The study also is associative causal research that seek causal influence of the variables to be studied. This research was conducted and involved nurses Orthopaedic Hospital Prof. Dr. R. Soeharso Surakarta. The number of samples of this study were 124 nurses Orthopaedic Hospital Orthopedics Prof. Dr. R. Soeharso Surakarta. The results showed that transformational leadership style influence on commitment, job satisfaction and nurses’ intent to move RSO Prof. Dr. R. Soeharso Surakarta with the mediating role of justice and trust.

  9. The Xanthophyceae and Chlorophyceae of the Western Ross Sea, Victoria Land, Antarctica and Macquarie Island collected under the direction of Prof. Dr. J. S. Zaneveld (1963—1967)

    NARCIS (Netherlands)

    Wagner, H.P.; Zaneveld, J.S.

    1988-01-01

    During the austral summer seasons of 1963-1964 and 1964-1965, and during the austral winter season of 1967 Prof. Dr. J.S. Zaneveld made collection expeditions to the western Ross Sea. In 1965 collections were also made from the U.S.C.G. icebreaker ‘Glacier’, around the western Ross Sea and around

  10. Editorial : Laudation to prof.dr. Hans-Toni Tarre- towards conceptual, theory-based ecological science and its transfer to the applied field of ecotoxicology

    NARCIS (Netherlands)

    Brock, T.C.M.; Giesy, J.P.; Heimbach, F.; Hollert, H.; Ross-Nickoll, M.; Schaffer, A.; Steinhauser, K.G.

    2011-01-01

    In order to thank Prof. Dr. Hans-Toni Ratte on the occasion of his retirement for his outstanding experimental and modelling merits in the field of ecotoxicology and ecology and his personal 65th anniversary on November 25th this article will present a laudation.

  11. 5-FU resistant EMT-like pancreatic cancer cells are hypersensitive to photochemical internalization of the novel endoglin-targeting immunotoxin CD105-saporin.

    Science.gov (United States)

    Lund, Kaja; Olsen, Cathrine Elisabeth; Wong, Judith Jing Wen; Olsen, Petter Angell; Solberg, Nina Therese; Høgset, Anders; Krauss, Stefan; Selbo, Pål Kristian

    2017-12-19

    Development of resistance to 5-fluorouracil (5-FU) is a major problem in treatment of various cancers including pancreatic cancer. In this study, we reveal important resistance mechanisms and photochemical strategies to overcome 5-FU resistance in pancreatic adenocarcinoma. 5-FU resistant (5-FUR), epithelial-to-mesenchymal-like sub-clones of the wild type pancreatic cancer cell line Panc03.27 were previously generated in our lab. We investigated the cytotoxic effect of the endosomal/lysosomal-localizing photosensitizer TPCS 2a (fimaporfin) combined with light (photochemical treatment, PCT) using MTS viability assay, and used fluorescence microscopy to show localization of TPCS 2a and to investigate the effect of photodamage of lysosomes. Flow cytometric analysis was performed to investigate uptake of photosensitizer and to assess intracellular ROS levels. Expression and localization of LAMP1 was assessed using RT-qPCR, western blotting, and structured illumination microscopy. MTS viability assay was used to assess the effect of combinations of 5-FU, chloroquine (CQ), and photochemical treatment. Expression of CD105 was investigated using RT-qPCR, western blotting, flow cytometry, and fluorescence microscopy, and co-localization of TPCS 2a and anti-CD105-saporin was assessed using microscopy. Lastly, the MTS assay was used to investigate cytotoxic effects of photochemical internalization (PCI) of the anti-CD105-immunotoxin. The 5-FUR cell lines display hypersensitivity to PCT, which was linked to increased uptake of TPCS 2a , altered lysosomal distribution, lysosomal photodamage and increased expression of the lysosomal marker LAMP-1 in the 5-FUR cells. We show that inhibition of autophagy induced by either chloroquine or lysosomal photodamage increases the sensitivity to 5-FU in the resistant cells. The three 5-FUR sub-clones overexpress Endoglin (CD105). Treatment with the immunotoxin anti-CD105-saporin alone significantly reduced the viability of the CD105

  12. Review of dissertation The Association Of Intelligence, Visual-Motor Functioning, And Personality Characteristics With Adaptive Behavior In Individuals With Williams Syndrome by Juhsin Trista Fu

    Directory of Open Access Journals (Sweden)

    Florova N.B.

    2015-06-01

    Full Text Available Juhsin Trista Fu (Taiwan is an American clinical psychologist, doctor of philosophy (PhD, on the national register of health professionals of United States National Provider Identifiers (NPI Registry. The proposed material gives a systematic description of the dynamics of specific behavioral construct in adults in situation of genetic anomalies. The author regards this condition as a volatile state which to a certain extent responds to interventions.

  13. EFECTO DEL GRITO COMO UN RECURSO ERGOGÉNICO PSICOLÓGICO EN PRACTICANTES DE KUNG FU

    Directory of Open Access Journals (Sweden)

    Juan Diego Zamora Salas

    2002-12-01

    Full Text Available El presente estudio analizó el efecto del grito como mecanismo inhibidor de sensaciones como el dolor y la fatiga enpracticantes de Kung Fu, utilizando una prueba de push ups. Se formaron tres grupos de forma aleatoria,cada uno conformado por n= 10, cuyas edades estaban comprendidas entre los 15 y 30 años. Los sujetos del Grupo Experimental sin grito y Grupo Experimental con grito, les correspondía realizar las prácticas depush ups aplicando los tratamientos correspondientes durante cinco semanas; mientras que los sujetos delgrupo control no realizaban éstas prácticas durante el período establecido, sólo les correspondía el pre-testy post-test. A los valores recolectados durante las pruebas se les aplicó una Anova 3 x 2 y un análisis posthocde la interacción mostrando la existencia de una diferencia significativa entre el pre-test y el post-testtanto en el grupo que aplicó el grito personal como en el grupo que no lo aplicó, lo cual no se manifestóentre el pre-test y post-test del grupo control. Al comparar los datos obtenidos del grupo que utilizó el gritopersonal con respecto al grupo que no utilizó el grito como tratamiento, se encontró una diferenciasignificativa entre ambos métodos. Con el estudio se concluyó que el grito en combinación con el ejerciciofísico permite observar incrementos significativos en la cantidad de repeticiones de un ejercicio de fuerzapara el tren superior como son las push ups, luego de cinco semanas de tratamiento.

  14. Antibacterial Activity of Copper Oxide (CuO Nanoparticles Biosynthesized by Bacillus sp. FU4: Optimization of Experiment Design

    Directory of Open Access Journals (Sweden)

    Mojtaba Taran, Maryam Rad, Mehran Alavi

    2017-09-01

    Full Text Available Background: There are several methods for synthesis of metallic nanoparticles (NPs including chemical, physical and biological process. In this study, Bacillus sp. FU4 was used as biological source for biosynthesis of CuO NPs. Methods: CuO NPs have been prepared by copper sulfate (CuSO4. CuO NPs were formed after oxidation of Cu NPs. Design and analysis of Taguchi experiments (an orthogonal assay and analysis of variance (ANOVA carried out by the Qualitek-4 software. Average effect of CuSO4 concentration (0.1, 0.01 and 0.001 M, incubation and culturing time (48, 72, 96 hours as three controllable factors with three levels were evaluated in CuO NPs biosynthesis. Characterization of CuO NPs was determined by UV-Vis spectroscopy, X-ray diffraction (XRD, Fourier transform infra-red (FT-IR spectroscopy and scanning electron microscopy (SEM. Also, the antimicrobial properties of CuO NPs were investigated using Escherichia coli ATCC 25922 and Staphylococcus aureus ATCC 43300 as multidrug resistant (MDR bacteria. Results: Results: It was evaluated that, NPs size distributions were in the range of 2-41 nm with spherical shapes. The anti-bacterial activities of CuO NPs were measured based on diameter of inhibition zone in disk diffusion tests of NPs dispersed in batch cultures. Two levels of CuSO4 concentrations (0.1 and 0.01M had antibacterial effect on E.coli (33±0.57 and 6 ±2mm. In the case of S. aureus, there was surprisingly no sign of growth. Conclusion: CuO NPs have antibacterial activity that can be benefit in medicinal aspect for fighting against prominent pathogen bacteria such as E.coli ATCC 25922 and S.aureus ATCC 43300.

  15. Pilot study of postoperative adjuvant chemoradiation for advanced gastric cancer: Adjuvant 5-FU/cisplatin and chemoradiation with capecitabine

    Science.gov (United States)

    Lee, Hyung-Sik; Choi, Youngmin; Hur, Won-Joo; Kim, Hyo-Jin; Kwon, Hyuk-Chan; Kim, Sung-Hyun; Kim, Jae-Seok; Lee, Jong-Hoon; Jung, Ghap-Joong; Kim, Min-Chan

    2006-01-01

    AIM: To evaluate the efficacy and toxicity of postoperative chemoradiation using FP chemotherapy and oral capecitabine during radiation for advanced gastric cancer following curative resection. METHODS: Thirty-one patients who had underwent a potentially curative resection for Stage III and IV (M0) gastric cancer were enrolled. Therapy consists of one cycle of FP (continuous infusion of 5-FU 1000 mg/m2 on d 1 to 5 and cisplatin 60 mg/m2 on d 1) followed by 4500 cGy (180 cGy/d) with capecitabine (1650 mg/m2 daily throughout radiotherapy). Four wk after completion of the radiotherapy, patients received three additional cycles of FP every three wk. The median follow-up duration was 22.2 mo. RESULTS: The 3-year disease free and overall survival in this study were 82.7% and 83.4%, respectively. Four patients (12.9%) showed relapse during follow-up. Eight patients did not complete all planned adjuvant therapy. Grade 3/4 toxicities included neutropenia in 50.2%, anemia in 12.9%, thrombocytopenia in 3.2% and nausea/vomiting in 3.2%. Neither grade 3/4 hand foot syndrome nor treatment related febrile neutropenia or death were observed. CONCLUSION: These preliminary results suggest that this postoperative adjuvant chemoradiation regimen of FP before and after capecitabine and concurrent radiotherapy appears well tolerated and offers a comparable toxicity profile to the chemoradiation regimen utilized in INT-0116. This treatment modality allowed successful loco-regional control rate and 3-year overall survival. PMID:16489675

  16. Therapeutic effects of FuZhiSan on Alzheimer's disease rat model:evaluation with PET imaging

    International Nuclear Information System (INIS)

    Guo Zhe; Zhang Jinming; Yao Shulin; Feng Huiru; Li Xuling; Yin Dayi; Tian Jiahe

    2010-01-01

    Objective: To assess the feasibility of using PET molecular imaging to evaluate the therapeutic effects of traditional Chinese medicine FuZhiSan (FZS) on the model of aging Alzheimer's disease (AD) rats. Methods: Twenty aged AD rats (Sparague-Dawley rats,male) were randomly divided into FZS treated group (n = 10) and control group (n = 10). Another 10 healthy adult rats were as blank controls. Morris water maze record system was used for cognitive function assessment. Before and after FZS treatment 18 F-fluorodeoxyglucose (FDG) and 11 C-2- [4'-(methylamino) phenyl] benzothiazol-6-ol (PIB) PET imaging was undertaken. After post-treatment imaging procedures the brain tissues of all animals were taken for histochemical study, such as staining with HE, congo red, amyloid β (Aβ) immunofluorescence, 5-bromo-2-deoxyuridine (BrdU) immunofluorescence and NeuN immunofluorescence. Paired t-test was performed with SPSS 13.0 software for the data analysis. Results: The cognitive dysfunction of aging AD rats was improved after FZS treatment. The escape latency in FZS treated group was significantly shorter than that of control group ((32.5 ±10.8) s vs (102.6±8.8) s, t =15.7987, P=0. 0001). Diffuse neuronal loss and Aβ deposition were detected in the hippocampus and cortex in the aged AD rats. The imaging data showed that brain glucose metabolism was amended in FZS treated group while the abatement of amyloid deposition was not significant. Immunofluorescence results indicated that the neuronal proliferation was more remarkable in FZS treated group. Conclusions: It may be feasible to use PET imaging as a method to evaluate the therapeutic effect in AD rats. FZS may ameliorate memory dysfunction of aged AD rats. Its mechanism may be partly contributed to the enhancement of the neuronal proliferation and survival. (authors)

  17. Kung Fu a jeho zařazení do výuky úpolů ve školní tělesné výchově

    OpenAIRE

    Krbcová, Pavlína

    2015-01-01

    The goal of this thesis is to analyse kung fu from the pespective of teaching Combatives in Physicial Education courses, suggest model exercises with the help of the consultants named in the theoretical part and create model lessons that teachers may use in their Physical Education courses. The teoretical part focuses on history, taxonomy and teaching of Combatives in Physical Education courses. In addition, in describes history, characteristics and taxonomy of kung fu. The experimental part ...

  18. Concurrent hyperfractionated accelerated radiotherapy with 5-FU and once weekly cisplatin in locally advanced head and neck cancer. The 10-year results of a prospective phase II trial

    Energy Technology Data Exchange (ETDEWEB)

    Budach, V.; Boehmer, D.; Badakhshi, H.; Jahn, U.; Stromberger, C. [Campus Virchow Klinikum, Charite Universitaetsmedizin Berlin, Department for Radiooncology, Clinic for Radiooncology, Berlin (Germany); Becker, E.T. [Charite Universitaetsmedizin, Department of Otorhinolaryngology, Berlin (Germany); Wernecke, K.D. [Sostana Statistics GmbH, Charite Universitaetsmedizin Berlin, Berlin (Germany)

    2014-03-15

    In this study, the acute toxicity and long-term outcome of a hyperfractionated accelerated chemoradiation regimen with cisplatin/5-fluorouracil (5-FU) in patients with locally advanced squamous cell carcinomas of head and neck were evaluated. From 2000-2002, 38 patients with stage III (5.3 %) and stage IV (94.7 %) head and neck cancer were enrolled in a phase II study. Patients received hyperfractionated-accelerated radiotherapy with 72 Gy in 15 fractions of 2 Gy followed by 1.4 Gy twice daily with concurrent, continuous infusion 5-FU of 600 mg/m{sup 2} on days 1-5 and 6 cycles of weekly cisplatin (30 mg/m{sup 2}). Acute toxicities (CTCAEv2.0), locoregional control (LRC), metastases-free (MFS), and overall survival (OS) were analyzed and exploratively compared with the ARO 95-06 trial. Median follow-up was 11.4 years (95 % CI 8.6-14.2) and mean dose 71.6 Gy. Of the patients, 82 % had 6 (n = 15) or 5 (n = 16) cycles of cisplatin, 5 and 2 patients received 4 and 3 cycles, respectively. Grade 3 anemia, leukopenia, and thrombocytopenia were observed in 15.8, 15.8, and 2.6 %, respectively. Grade 3 mucositis in 50 %, grade 3 and 4 dysphagia in 55 and 13 %. The 2-, 5-, and 10-year LRC was 65, 53.6, and 48.2 %, the MFS was 77.5, 66.7, and 57.2 % and the OS 59.6, 29.2, and 15 %, respectively. Chemoradiation with 5-FU and cisplatin seems feasible and superior in terms of LRC and OS to the ARO 95-06C-HART arm at 2 years. However, this did not persist at the 5- and 10-year follow-ups. (orig.) [German] Untersuchung der Akuttoxizitaet und des Langzeitueberlebens einer hyperfraktioniert-akzelerierten simultanen Radiochemotherapie mit Cisplatin/5-Fluorouracil (5-FU) bei Patienten mit lokal fortgeschrittenen Kopf-Hals-Tumoren. Von 2000 bis 2002 wurden 38 Patienten mit Plattenepithelkarzinomen der Kopf-Hals-Region im Stadium III (5,3 %) und IV (94,7 %) eingeschlossen. Es erfolgte eine simultane hyperfraktionierte akzelerierte Radiochemotherapie mit 72 Gy in 15 Fraktionen a 2 Gy

  19. K3FU METAR

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — METAR is a routine scheduled observation and is the primary observation code used in the United States to satisfy requirements for reporting surface meteorological...

  20. Quantum kung fu

    Science.gov (United States)

    Flicker, Felix

    2014-07-01

    If someone puts you in an armlock, what should you do? If you happen to be a martial artist well-practised in the art of joint manipulation, or chin na, you will know the answer already: there is one simple move that will allow you to turn the tables on your aggressor, leaving them on the wrong end of a throw.

  1. Efek Electro Convulsive Therapy (ECT terhadap Daya Ingat Pasien Skizofrenia di RSJ Prof. HB. Sa’anin Padang

    Directory of Open Access Journals (Sweden)

    Ikky Nabila Nandinanti

    2015-09-01

    Full Text Available Abstrak  ECT merupakan terapi kejang listrik dengan menghantarkan arus listrik pada elektroda dan dipasang pada kepala sehingga menyebabkan konvulsi. ECT terbukti dapat memperbaiki gejala skizofrenia, namun ECT juga memiliki efek samping terutama pada daya ingat. Tujuan  penelitian ini adalah mengetahui efek ECT terhadap daya ingat pasien skizofrenia. Metode : Penelitian ini menggunakan desain analitik dengan jumlah sampel 15 orang penderita skizofrenia di Rumah Sakit Jiwa (RSJ Prof. HB. Sa’anin Padang dengan teknik pengambilan consecutive sampling.Pemeriksaan daya ingat menggunakan Tes Memori Indonesia, dilakukan sehari sebelum ECT dan 2 jam sesudah ECT. Analisis data dengan uji T berpasangan. Gangguan daya ingat sebelum ECT terjadi pada 90% sampel dengan terganggu sedang pada kemampuan immediate memory, terganggu ringan pada kemampuan recent memory, dan terganggu berat pada remote memory. Gangguan daya ingat sesudah ECT terjadi pada seluruh sampel (100% dengan terganggu sedang pada immediate memory, terganggu berat pada recent memory, dan terganggu berat padaremote memory. Uji hipotesis pada nilai kemampuan immediate dan recent memory menghasilkan nilai p 0,018 dan 0,031 (p < 0,05, berarti Ho ditolak, sedangkan nilai p remote memory 0,678 (p > 0,05, berarti Ho diterima. Kesimpulan adalah perbedaan daya ingat immediate dan recent memory pada pasien skizofrenia sebelum dan sesudah ECT, sedangkan kemampuan remote memory tidak mengalami perubahan.Kata kunci: skizofrenia, ECT, daya ingat Abstract ECT is an electric convulsive therapy by delivering electrical current to electrodes and mounted on the head causing convulsions. ECT shown to improve schizophrenia symptoms, but ECT also has side effects especially on memory. The objective of this study was to determine the effects of ECT on memory schizophrenic patients. Current study was conducted with analytic design with sample size was 15 schizophrenia people at RSJ Prof. HB. Sa'anin Padang

  2. [Isolation and characterization of petroleum catabolic broad-host-range plasmids from Shen-Fu wastewater irrigation zone].

    Science.gov (United States)

    Wang, Ya-Fei; Wang, Ya-Fei; Li, Hui; Li, Xiao-Bin

    2013-11-01

    Based on triparental mating, we isolated a total of eight broad host range (BHR) petroleum hydrocarbon catabolic plasmids from the soils, sediments, and wastewater samples in the Shen-Fu irrigation zone. The antibiotic resistance of the plasmids was tested, and then, the plasmids were transferred to Escherichia coli EC100. The plasmids carrying no antibiotic resistance were tagged by miniTn5 transposon consisting of antibiotic resistant genes. The PCR-based incompatibility test revealed that the pS3-2C and pS4-6G belonged to Inc P group, the pS3-2G, pW22-3G, and pA15-7G belonged to Inc N group, the pS7-2G was identified as Inc W plasmid, and the pA23-1G and pA10-1C were placed into Inc Q group. By adopting the reported PCR amplification methods of petroleum hydrocarbon-degrading catabolic genes, the petroleum-degrading capability of these BHR plasmids were preliminarily analyzed. The plasmids pS3-2G, pS7-2G, pA23-1G, pW22-3G, and pA10-1C carried aromatic ring- hydroxylating dioxygenase gene phdA and toluene monooxygenase gene touA; the plasmid pA15-7G carried touA and toluene dioxygenase gene tod; the plasmid pS3-2C carried ben, phdA, and tod; whereas the pS4-6G only carried ben. The host range test showed that all the isolated plasmids except pS3-2C could be transferred and maintained stably in the representative strains Agrobacterium tumefaciens C58, Cupriavidus necator JMP228, and E. coli EC100 of the alpha-, beta-, and gamma-Proteobacteria, respectively.

  3. Effective inhibition of colon cancer cell growth with MgAl-layered double hydroxide (LDH loaded 5-FU and PI3K/mTOR dual inhibitor BEZ-235 through apoptotic pathways

    Directory of Open Access Journals (Sweden)

    Chen J

    2014-07-01

    Full Text Available Jiezhong Chen,1,2 Renfu Shao,3 Li Li,4 Zhi Ping Xu,4 Wenyi Gu4 1School of Biomedical Sciences, University of Queensland, St Lucia, Queensland, 2Faculty of Science, Medicine and Health, University of Wollongong, Wollongong, New South Wales, 3GeneCology Research Centre, Faculty of Science, Health, Education and Engineering, University of the Sunshine Coast, Maroochydore, Queensland, 4Australian Institute of Bioengineering and Nanotechnology, University of Queensland, St Lucia, Queensland, Australia Abstract: Colon cancer is the third most common cancer and the third largest cause of cancer-related death. Fluorouracil (5-FU is the front-line chemotherapeutic agent for colon cancer. However, its response rate is less than 60%, even in combination with other chemotherapeutic agents. The side effects of 5-FU also limit its application. Nanoparticles have been used to deliver 5-FU, to increase its effectiveness and reduce side effects. Another common approach for colon cancer treatment is targeted therapy against the phosphoinositide 3-kinase (PI3K/protein kinase B (Akt pathway. A recently-invented inhibitor of this pathway, BEZ-235, has been tested in several clinical trials and has shown effectiveness and low side effects. Thus, it is a very promising drug for colon cancer treatment. The combination of these two drugs, especially nanoparticle-packed 5-FU and BEZ-235, has not been studied. In the present study, we demonstrated that nanoparticles of layered double hydroxide (LDH loaded with 5-FU were more effective than a free drug at inhibiting colon cancer cell growth, and that a combination treatment with BEZ-235 further increased the sensitivity of colon cancer cells to the treatment of LDH-packed 5-FU (LDH-5-FU. BEZ-235 alone can decrease colon cancer HCT-116 cell viability to 46% of the control, and the addition of LDH-5-FU produced a greater effect, reducing cell survival to 8% of the control. Our data indicate that the combination therapy of

  4. 1st Händel School of Modern Epidemiology in Halle, October 3-6, 2005 with Prof. Kenneth J. Rothman

    Directory of Open Access Journals (Sweden)

    Stang, Andreas

    2005-12-01

    Full Text Available The Händel School of Modern Epidemiology is dedicated to the education of scientists and students who have a particular interest in modern epidemiologic methods. The school is named after the famous Georg Friederich Händel who was born in Halle (Saale in 1685. The Händel School will be held once per year in October. This year's opening school was given by Prof. Kenneth J. Rothman from Boston University. The course covered several methodological topics that attracted a wide range of scientists and students from seven European countries. The next year's Händel School lecturer will be Prof. Albert Hofman, Erasmus University, Rotterdam, who will cover modern methods of clinical epidemiology.

  5. Microstructural characterisation of battery materials using powder diffraction data: DIFFaX, FAULTS and SH-FullProf approaches

    Energy Technology Data Exchange (ETDEWEB)

    Casas-Cabanas, M.; Canales-Vazquez, J.; Palacin, M.R. [Institut de Ciencia de Materials de Barcelona (CSIC), Barcelona 08913 (Spain); Rodriguez-Carvajal, J. [Laboratoire Leon Brillouin (CEA-CNRS), Saclay, 91191 Gif-sur-Ivette Cedex (France); Laligant, Y.; Lacorre, P. [Laboratoire des Oxydes et Fluorures, UMR CNRS 6010, Universite du Maine, 72085 Le Mans Cedex (France)

    2007-12-06

    The microstructure of Li{sub 2}PtO{sub 3}, isostructural with Li{sub 2}MnO{sub 3}, and {beta}-Ni(OH){sub 2} is analyzed from powder diffraction data using two approaches. Firstly, the recently developed FAULTS program (a modification of the DIFFaX program to allow refinement of the diffraction pattern) is used to include different amounts and types of stacking faults in the microstructural description of the material. This approach treats size effects mostly isotropically and assigns most of the anisotropic peak broadening to stacking faults. On the other hand, the FullProf program is also used to perform Rietveld refinement with microstructural models that treat the effects of anisotropic size and hence considers that this is the main contribution to broadening. The simultaneous use of these two approaches allows choosing the most adequate model in each particular case in order to obtain an accurate description of the microstructure of the material. (author)

  6. MODEL KUANTITATIF MANAJEMEN STRES KERJA DAN MOTIVASI UNTUK MENINGKATKAN KINERJA PETUGAS REKAM MEDIS DI RS ORTOPEDI PROF. DR. R. SOEHARSO SURAKARTA

    OpenAIRE

    Laili Rahmatul Ilmi

    2016-01-01

    Background: Workload may indirectly cause stress. The ability to manage work stress may affect staff’s motivation and performance. The staff performance will affect decision-making in improving the service quality. Objective: This study aimed to analyze the relationship between stress management, work motivation and work performance. Method: This was an analytic observational study with a cross sectional approach. A sample of 19 medical record staff, working at Prof. Dr. R Soeharso ort...

  7. The Honorable William Nelson, Senior Senator from Florida, Chairman, Senate Committee on Space, Aeronautics and Related Sciences signing the golden book. Greeting by Mr Robert Aymar, CERN Director General and Prof. Samuel Ting from the MIT.

    CERN Multimedia

    Maximilien Brice

    2008-01-01

    The Honorable William Nelson, Senior Senator from Florida, Chairman, Senate Committee on Space, Aeronautics and Related Sciences signing the golden book. Greeting by Mr Robert Aymar, CERN Director General and Prof. Samuel Ting from the MIT.

  8. The Honorable William Nelson, Senior Senator from Florida, Chairman, Senate Committee on Space, Aeronautics and Related Sciences visiting the AMS Hall of Prevessin with Prof. Samuel Ting from the MIT.

    CERN Multimedia

    Maximilien Brice

    2008-01-01

    The Honorable William Nelson, Senior Senator from Florida, Chairman, Senate Committee on Space, Aeronautics and Related Sciences visiting the AMS Hall of Prevessin with Prof. Samuel Ting from the MIT.

  9. Mr Bikash Sinha, Director of SAHA & VECC and Prof. Rolf Heuer, Director general of CERN, sign a collaboration agreements between SAHA (Saha Institute of Nuclear Physics), VECC (Variable Energy Cyclotron Centre), India and CERN ISOLDE.

    CERN Multimedia

    Maximilien Brice

    2009-01-01

    Mr Bikash Sinha, Director of SAHA & VECC and Prof. Rolf Heuer, Director general of CERN, sign a collaboration agreements between SAHA (Saha Institute of Nuclear Physics), VECC (Variable Energy Cyclotron Centre), India and CERN ISOLDE.

  10. Dr Phil Mjwara Director General, Department of Science and Technology (DST) Ministry of Science and Technology Republic of South Africa visit the Alice experiment introduce by Prof. Jurgen Schukraft, spokeperson for Alice.

    CERN Multimedia

    Maximilien Brice

    2007-01-01

    Dr Phil Mjwara Director General, Department of Science and Technology (DST) Ministry of Science and Technology Republic of South Africa visit the Alice experiment introduce by Prof. Jurgen Schukraft, spokeperson for Alice.

  11. 18 MArch 2008 - Director, Basic and Generic Research Division, Research Promotion Bureau, Japanese Ministry of Education, Culture, Sports, Science and Technology Prof.Ohtake visiting ATLAS cavern with Spokesperson P. Jenni.

    CERN Multimedia

    Maximilien Brice

    2008-01-01

    18 MArch 2008 - Director, Basic and Generic Research Division, Research Promotion Bureau, Japanese Ministry of Education, Culture, Sports, Science and Technology Prof.Ohtake visiting ATLAS cavern with Spokesperson P. Jenni.

  12. 21 October 2008 - LHC Inauguration - IHEP Beijing representative Prof. Chen, People's Republic of China, welcomed by CERN Director-General R. Aymar, CERN Chief Scientific Officer J. Engelen and CERN Financial Officer S. Lettow.

    CERN Multimedia

    CERN Photo Service

    2008-01-01

    21 October 2008 - LHC Inauguration - IHEP Beijing representative Prof. Chen, People's Republic of China, welcomed by CERN Director-General R. Aymar, CERN Chief Scientific Officer J. Engelen and CERN Financial Officer S. Lettow.

  13. Signature of the Collaboration agreement contract between CERN and IASS on High Current, Long Distance Superconducting Power Transmission Lines signed Dr.Steve Myers Director of Acc Tech and Prof. Carlo Rubbia.

    CERN Multimedia

    Maximilien Brice

    2012-01-01

    Signature of the Collaboration agreement contract between CERN and IASS on High Current, Long Distance Superconducting Power Transmission Lines signed Dr.Steve Myers Director of Acc Tech and Prof. Carlo Rubbia.

  14. Signature of the CERN – EGO (European Gravitational Observatory) Agreement concerning Collaboration in Scientific, Technological, Educational and other Domains of Mutual Interest, by R. Heuer, Director-General and Prof. F. Ferrini.

    CERN Multimedia

    Maximilien Brice

    2012-01-01

    Signature of the CERN – EGO (European Gravitational Observatory) Agreement concerning Collaboration in Scientific, Technological, Educational and other Domains of Mutual Interest, by R. Heuer, Director-General and Prof. F. Ferrini.

  15. Visit of H.E. Mr. Attila Chikan, Minister of Economic Affairs, Prof. Adam Török, President, National Committee for Technological Development, Mr. Pal Koncz, Deputy Director General, National Committee for Technological Development, Hungary

    CERN Multimedia

    Laurent Guiraud

    1999-01-01

    Visit of H.E. Mr. Attila Chikan, Minister of Economic Affairs, Prof. Adam Török, President, National Committee for Technological Development, Mr. Pal Koncz, Deputy Director General, National Committee for Technological Development, Hungary

  16. Prof. Manuel Trajtenberg, Chair of the Planning and Budget Committee, Council for Higher Education in Israel with CERN Director-General R. Heuer and in front of the ATLAS detector on Thursday 14th January.

    CERN Multimedia

    Maximilien Brice; Point 1

    2010-01-01

    Prof. Manuel Trajtenberg, Chair of the Planning and Budget Committee, Council for Higher Education in Israel with CERN Director-General R. Heuer and in front of the ATLAS detector on Thursday 14th January.

  17. Prof. Cristoforo Benvenuti stands in front of solar panels installed on the roof of Geneva airport. These panels, produced by the commpany SRB, are based on a technology developed at CERN by Cristoforo Benvenuti.

    CERN Document Server

    Maximilien Brice

    2012-01-01

    Prof. Cristoforo Benvenuti stands in front of solar panels installed on the roof of Geneva airport. These panels, produced by the commpany SRB, are based on a technology developed at CERN by Cristoforo Benvenuti.

  18. Establishment of a new human pleomorphic malignant fibrous histiocytoma cell line, FU-MFH-2: molecular cytogenetic characterization by multicolor fluorescence in situ hybridization and comparative genomic hybridization

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    Isayama Teruto

    2010-11-01

    Full Text Available Abstract Background Pleomorphic malignant fibrous histiocytoma (MFH is one of the most frequent malignant soft tissue tumors in adults. Despite the considerable amount of research on MFH cell lines, their characterization at a molecular cytogenetic level has not been extensively analyzed. Methods and results We established a new permanent human cell line, FU-MFH-2, from a metastatic pleomorphic MFH of a 72-year-old Japanese man, and applied multicolor fluorescence in situ hybridization (M-FISH, Urovysion™ FISH, and comparative genomic hybridization (CGH for the characterization of chromosomal aberrations. FU-MFH-2 cells were spindle or polygonal in shape with oval nuclei, and were successfully maintained in vitro for over 80 passages. The histological features of heterotransplanted tumors in severe combined immunodeficiency mice were essentially the same as those of the original tumor. Cytogenetic and M-FISH analyses displayed a hypotriploid karyotype with numerous structural aberrations. Urovysion™ FISH revealed a homozygous deletion of the p16INK4A locus on chromosome band 9p21. CGH analysis showed a high-level amplification of 9q31-q34, gains of 1p12-p34.3, 2p21, 2q11.2-q21, 3p, 4p, 6q22-qter, 8p11.2, 8q11.2-q21.1, 9q21-qter, 11q13, 12q24, 15q21-qter, 16p13, 17, 20, and X, and losses of 1q43-qter, 4q32-qter, 5q14-q23, 7q32-qter, 8p21-pter, 8q23, 9p21-pter, 10p11.2-p13, and 10q11.2-q22. Conclusion The FU-MFH-2 cell line will be a particularly useful model for studying molecular pathogenesis of human pleomorphic MFH.

  19. Neoadjuvant Treatment With Single-Agent Cetuximab Followed by 5-FU, Cetuximab, and Pelvic Radiotherapy: A Phase II Study in Locally Advanced Rectal Cancer

    International Nuclear Information System (INIS)

    Bertolini, Federica; Chiara, Silvana; Bengala, Carmelo; Antognoni, Paolo; Dealis, Cristina; Zironi, Sandra; Malavasi, Norma; Scolaro, Tindaro; Depenni, Roberta; Jovic, Gordana; Sonaglio, Claudia; Rossi, Aldo; Luppi, Gabriele; Conte, Pier Franco

    2009-01-01

    Purpose: Preoperative chemoradiotherapy followed by surgery represents the standard of care for locally advanced rectal cancer (LARC). Cetuximab has proved activity in advanced colorectal cancer, and its incorporation in preoperative treatment may increase tumor downstaging. Methods and Materials: After biopsy and staging, uT3/uT4 N0/+ LARC received single-agent cetuximab in three doses, followed by weekly cetuximab plus 5-fluorouracil (5-FU), concomitantly with RT. Sample size was calculated according to Bryant and Day test, a two-stage design with at least 10 pathologic complete remissions observed in 60 patients (pts) able to complete the treatment plan. Results: Forty pts with LARC were entered: male/female = 34/6; median age: 61 (range, 28-77); 12 uT3N0 Ed(30%); 25 uT3N1 (62%); 3 uT4N1 (8%); all Eastern Cooperative Oncology Group = 0. Thirty-five pts completed neoadjuvant treatment; 5 (12%) withdrew therapy after one cetuximab administration: three for hypersensitivity reactions, one for rapid progression, and one for purulent arthritis. They continued 5-FU in continuous infusion in association with RT. Thirty-one pts (77%) presented with acnelike rash; dose reduction/interruption of treatment was necessary in six pts (15%): two for Grade 3 acnelike rash, two for Grade 3 gastrointestinal toxicity, and two for refusal. Thirty-eight pts were evaluable for pathological response (one patient refused surgery, and one was progressed during neoadjuvant treatment). Pathological staging was: pT0N0 three pts (8%), pT1N0 1 pt (3%); pT2N0 13 pts (34%), and pT3 19 pts (50%) (N0:9, N1:5; N2:5); pT4 2 pts (5%). Conclusions: Preoperative treatment with 5-FU, cetuximab, and pelvic RT is feasible with acceptable toxicities; however, the rate of pathologic responses is disappointingly low

  20. The dose-volume relationship of acute small bowel toxicity from concurrent 5-FU-based chemotherapy and radiation therapy for rectal cancer

    International Nuclear Information System (INIS)

    Baglan, Kathy L.; Frazier, Robert C.; Yan Di; Huang, Raywin R.; Martinez, Alvaro A.; Robertson, John M.

    2002-01-01

    Purpose: A direct relationship between the volume of small bowel irradiated and the degree of acute small bowel toxicity experienced during concurrent 5-fluorouracil (5-FU)-based chemoradiotherapy for rectal carcinoma is well recognized but poorly quantified. This study uses three-dimensional treatment-planning tools to more precisely quantify this dose-volume relationship. Methods and Materials: Forty patients receiving concurrent 5-FU-based chemotherapy and pelvic irradiation for rectal carcinoma had treatment-planning CT scans with small bowel contrast. A median isocentric dose of 50.4 Gy was delivered using a posterior-anterior and opposed lateral field arrangement. Bowel exclusion techniques were routinely used, including prone treatment position on a vacuum bag cradle to allow anterior displacement of the abdominal contents and bladder distension. Individual loops of small bowel were contoured on each slice of the planning CT scan, and a small bowel dose-volume histogram was generated for the initial pelvis field receiving 45 Gy. The volume of small bowel receiving each dose between 5 and 40 Gy was recorded at 5-Gy intervals. Results: Ten patients (25%) experienced Common Toxicity Criteria Grade 3+ acute small bowel toxicity. A highly statistically significant association between the development of Grade 3+ acute small bowel toxicity and the volume of small bowel irradiated was found at each dose level. Specific dose-volume threshold levels were found, below which no Grade 3+ toxicity occurred and above which 50-60% of patients developed Grade 3+ toxicity. The volume of small bowel receiving at least 15 Gy (V 15 ) was strongly associated with the degree of toxicity. Univariate analysis of patient and treatment-related factors revealed no other significant predictors of severe toxicity. Conclusions: A strong dose-volume relationship exists for the development of Grade 3+ acute small bowel toxicity in patients receiving concurrent 5-FU-based chemoradiotherapy

  1. Suppression of microRNA-31 increases sensitivity to 5-FU at an early stage, and affects cell migration and invasion in HCT-116 colon cancer cells

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    Sun Xiao-Feng

    2010-11-01

    Full Text Available Abstract Background MicroRNAs (miRNAs are endogenously expressed noncoding RNAs with important biological and pathological functions. Although several studies have shown that microRNA-31 (miR-31 is obviously up-regulated in colorectal cancer (CRC, there is no study on the functional roles of miR-31 in CRC. Methods Anti-miR™ miRNA 31 inhibitor (anti-miR-31 is a sequence-specific and chemically modified oligonucleotide to specifically target and knockdown miR-31 molecule. The effect of anti-miR-31 transfection was investigated by real-time PCR. HCT-116p53+/+ and HCT-116p53-/-colon cancer cells were treated by anti-miR-31 with or without 5-fluorouracil (5-FU, cell proliferation was determined by MTT assay; apoptosis was detected by DAPI staining; cell cycle was evaluated by flow cytometry; colony formation, migration and invasion assays were performed to investigate the effect of suppression of miR-31 on the cell lines. Results Real-time PCR results showed that anti-miR-31 was efficiently introduced into the cells and reduced miR-31 levels to 44.1% in HCT-116p53+/+ and 67.8% in HCT-116p53-/-cell line (p = 0.042 and 0.046. MTT results showed that anti-miR-31 alone had no effect on the proliferation of HCT-116p53+/+ or HCT-116p53-/-. However, when combined with 5-FU, anti-miR-31 inhibited the proliferation of the two cell lines as early as 24 h after exposure to 5-FU (p = 0.038 and 0.044. Suppression of miR-31 caused a reduction of the migratory cells by nearly 50% compared with the negative control in both HCT-116p53+/+ and HCT-116p53-/-(p = 0.040 and 0.001. The invasive ability of the cells were increased by 8-fold in HCT-116p53+/+ and 2-fold in HCT-116p53-/- (p = 0.045 and 0.009. Suppression of miR-31 had no effect on cell cycle and colony formation (p > 0.05. Conclusions Suppression of miR-31 increases sensitivity to 5-FU at an early stage, and affects cell migration and invasion in HCT-116 colon cancer cells.

  2. Evaluation of RRTMG and Fu-Liou RTM Performance against LBLRTM-DISORT Simulations and CERES Data in terms of Ice Clouds Radiative Effects

    Science.gov (United States)

    Gu, B.; Yang, P.; Kuo, C. P.; Mlawer, E. J.

    2017-12-01

    Evaluation of RRTMG and Fu-Liou RTM Performance against LBLRTM-DISORT Simulations and CERES Data in terms of Ice Clouds Radiative Effects Boyan Gu1, Ping Yang1, Chia-Pang Kuo1, Eli J. Mlawer2 Department of Atmospheric Sciences, Texas A&M University, College Station, TX 77843, USA Atmospheric and Environmental Research (AER), Lexington, MA 02421, USA Ice clouds play an important role in climate system, especially in the Earth's radiation balance and hydrological cycle. However, the representation of ice cloud radiative effects (CRE) remains significant uncertainty, because scattering properties of ice clouds are not well considered in general circulation models (GCM). We analyze the strengths and weakness of the Rapid Radiative Transfer Model for GCM Applications (RRTMG) and Fu-Liou Radiative Transfer Model (RTM) against rigorous LBLRTM-DISORT (a combination of Line-By-Line Radiative Transfer Model and Discrete Ordinate Radiative Transfer Model) calculations and CERES (Clouds and the Earth's Radiant Energy System) flux observations. In total, 6 US standard atmospheric profiles and 42 atmospheric profiles from Atmospheric and Environmental Research (AER) Company are used to evaluate the RRTMG and Fu-Liou RTM by LBLRTM-DISORT calculations from 0 to 3250 cm-1. Ice cloud radiative effect simulations with RRTMG and Fu-Liou RTM are initialized using the ice cloud properties from MODIS collection-6 products. Simulations of single layer ice cloud CRE by RRTMG and LBLRTM-DISORT show that RRTMG, neglecting scattering, overestimates the TOA flux by about 0-15 W/m2 depending on the cloud particle size and optical depth, and the most significant overestimation occurs when the particle effective radius is small (around 10 μm) and the cloud optical depth is intermediate (about 1-10). The overestimation reduces significantly when the similarity rule is applied to RRTMG. We combine ice cloud properties from MODIS Collection-6 and atmospheric profiles from the Modern

  3. Neoadjuvant 5-FU or Capecitabine Plus Radiation With or Without Oxaliplatin in Rectal Cancer Patients: A Phase III Randomized Clinical Trial

    Science.gov (United States)

    Yothers, Greg; O’Connell, Michael J.; Beart, Robert W.; Wozniak, Timothy F.; Pitot, Henry C.; Shields, Anthony F.; Landry, Jerome C.; Ryan, David P.; Arora, Amit; Evans, Lisa S.; Bahary, Nathan; Soori, Gamini; Eakle, Janice F.; Robertson, John M.; Moore, Dennis F.; Mullane, Michael R.; Marchello, Benjamin T.; Ward, Patrick J.; Sharif, Saima; Roh, Mark S.; Wolmark, Norman

    2015-01-01

    Background: National Surgical Adjuvant Breast and Bowel Project R-04 was designed to determine whether the oral fluoropyrimidine capecitabine could be substituted for continuous infusion 5-FU in the curative setting of stage II/III rectal cancer during neoadjuvant radiation therapy and whether the addition of oxaliplatin could further enhance the activity of fluoropyrimidine-sensitized radiation. Methods: Patients with clinical stage II or III rectal cancer undergoing preoperative radiation were randomly assigned to one of four chemotherapy regimens in a 2x2 design: CVI 5-FU or oral capecitabine with or without oxaliplatin. The primary endpoint was local-regional tumor control. Time-to-event endpoint distributions were estimated using the Kaplan-Meier method. Hazard ratios were estimated from Cox proportional hazard models. All statistical tests were two-sided. Results: Among 1608 randomized patients there were no statistically significant differences between regimens using 5-FU vs capecitabine in three-year local-regional tumor event rates (11.2% vs 11.8%), 5-year DFS (66.4% vs 67.7%), or 5-year OS (79.9% vs 80.8%); or for oxaliplatin vs no oxaliplatin for the three endpoints of local-regional events, DFS, and OS (11.2% vs 12.1%, 69.2% vs 64.2%, and 81.3% vs 79.0%). The addition of oxaliplatin was associated with statistically significantly more overall and grade 3–4 diarrhea (P < .0001). Three-year rates of local-regional recurrence among patients who underwent R0 resection ranged from 3.1 to 5.1% depending on the study arm. Conclusions: Continuous infusion 5-FU produced outcomes for local-regional control, DFS, and OS similar to those obtained with oral capecitabine combined with radiation. This study establishes capecitabine as a standard of care in the pre-operative rectal setting. Oxaliplatin did not improve the local-regional failure rate, DFS, or OS for any patient risk group but did add considerable toxicity. PMID:26374429

  4. Estudo clínico-patológico do pilomatrixoma palpebral: experiência no hospital universitário Prof. Edgard Santos Clinicopathologic study of eyelid pilomatrixoma: the experience of the "Hospital Universitário Prof. Edgard Santos"

    Directory of Open Access Journals (Sweden)

    Eduardo Ferrari Marback

    2007-06-01

    Full Text Available OBJETIVO: Relatar a experiência com pilomatrixoma palpebral no Hospital Universitário Profº. Edgard Santos, em período de 30 anos. MÉTODOS: Revisão no Registro do Laboratório de Patologia Ocular, de todos os casos de tumores palpebrais no período de 1974 a 2004. Após a identificação dos casos de pilomatrixoma, foram coletados dados referentes a gênero, idade, tempo de sintomatologia, aspecto, localização e suspeita diagnóstica inicial. As lâminas coradas pela hematoxilina e eosina foram revisadas. RESULTADOS: Dentre os 621 casos de tumores palpebrais, quatro eram de pilomatrixoma (0,64%. Três pacientes eram do sexo masculino. A idade média foi de 25 anos, variando de 8 a 54. O tempo de sintomatologia médio foi de cinco meses, variando de 2 a 12. Em três casos a lesão localizava-se na pálpebra inferior. Em apenas um caso o diagnóstico clínico foi correto. Ao exame anatomopatológico, dois casos apresentavam pseudocápsula. O caso cuja sintomatologia foi mais prolongada exibia predominância de células do tipo fantasma. Reação tipo corpo estranho foi vista em todos os casos, calcificação em apenas um. CONCLUSÕES: Trata-se de tumor benigno bastante raro, acometendo principalmente jovens. Devido a sua raridade e pleomorfismo à apresentação, dificilmente o diagnóstico clínico é correto.PURPOSE: To report the experience with eyelid pilomatrixoma during 30 years in a university hospital. METHODS: A review of the Ophthalmic Pathology Laboratory at the "Hospital Universitario Prof. Edgard Santos", was conducted to identify eyelid tumor cases from 1974 to 2004. After identification of pilomatrixoma cases, a chart review retrieved data regarding gender, age, duration of symptoms, gross aspect, anatomic localization and clinical diagnosis. The hematoxilin and eosin stained sections were reviewed. RESULTS: Of a total of 621 eyelid tumors, four (0.64% were pilomatrixomas. Three patients were male. The mean age at diagnosis

  5. 浅析脏腑理论与方剂配伍的关系%A brief Analysis on the Relationship between the Zang Fu Theory and Compatibility of Formula

    Institute of Scientific and Technical Information of China (English)

    齐放; 徐大鹏; 李明

    2013-01-01

    Each Zang-Fu organ has its own physiological characteristics .The relationships of inter-promotion and inter-restraint exist a-mong the Zang-Fu organs.Compatibility of formula can be modified according to physiological characteristics of the Zang and Fu organs and the relationships of inter-promotion and inter-restraint among the Zang and Fu organs .The Zang and Fu theory is an effective way to research the compatibility of formula and guide its clinical modification .%每个脏腑具有各自的生理特点,脏腑之间存在着相生相克的关系,方剂可以仿照脏腑的生理特点和脏腑之间生克制化的关系组方配伍。脏腑理论是研究方剂配伍和指导临证组方的有效途径。

  6. Effects of Shen-Fu Injection on the Expression of T-Cell-Specific Transcription Factors T-bet/Gata-3 in Porcine Postresuscitation Lung Injury

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    Wei Gu

    2013-01-01

    Full Text Available Shen-Fu injection (SFI derived from the ancient traditional Chinese medicine. In this study, the effects of SFI on the expression of T-bet/GATA-3 and its potential mechanisms causing the shift of T cells from Th2 to Th1 on postresuscitation lung injury were examined in a porcine model of cardiac arrest. 30 pigs were randomly divided into SHAM ( and three return of spontaneous circulation (ROSC groups ( per group; 24 pigs were subjected to 8 min of electrically induced cardiac arrest and 2 min of basic life support, which received central venous injection of Shen-Fu (SFI, epinephrine (EP or saline (SA. After successful ROSC, 18 surviving pigs were sacrificed at 24 h after ROSC ( per group. The levels of serum and lung tissue interleukin (IL-4 and interferon (IFN-γ were measured by ELISA, and the protein and mRNA levels of GATA-3 and T-bet in the lung tissue were determined by western blotting and quantitative real-time polymerase chain reaction, respectively. Compared with the EP and SA groups, SFI treatment reduced the levels of IL-4 (, increased levels of IFN-γ (, and induced T-bet mRNA upregulation and GATA-3 mRNA downregulation (. SFI attenuated lung injury and regulated lung immune disorders. Therefore, SFI could protect postresuscitation lung injury by modulating a Th1/Th2 imbalance.

  7. USP22 knockdown enhanced chemosensitivity of hepatocellular carcinoma cells to 5-Fu by up-regulation of Smad4 and suppression of Akt.

    Science.gov (United States)

    Zhang, Jing; Luo, Nan; Tian, Yu; Li, Jiazhi; Yang, Xiaozhou; Yin, Huimin; Xiao, Congshu; Sheng, Jie; Li, Yang; Tang, Bo; Li, Rongkuan

    2017-04-11

    USP22, a member of the deubiquitinases (DUBs) family, is known to be a key subunit of the human Spt-Ada-Gcn5 acetyltransferase (hSAGA) transcriptional cofactor complex. Within hSAGA, USP22 removes ubiquitin from histone proteins, thus regulating the transcription and expression of downstream genes. USP22 plays important roles in many cancers; however, its effect and the mechanism underlying HCC chemoresistance remain unclear. In the present study, we found that USP22 was highly expressed in chemoresistant HCC tissues and cells and was correlated with the prognosis of HCC patients who received chemotherapy. Silencing USP22 in chemoresistant HCC Bel/Fu cells dramatically inhibited proliferation, migration, invasion and epithelial-mesenchymal transition in vitro; suppressed tumorigenic and metastatic capacities in vivo; and inhibited drug resistance-related proteins (MDR1, LRP, MRP1). Mechanistically, we found that USP22 knockdown exerts its function through down-regulating PI3K and activating Smad4, which inhibited phosphorylation of Akt. Silencing Smad4 blocked USP22 knockdown-induced Akt inhibition in Bel/Fu cells. Our results, for the first time, provide evidence that USP22 plays a critical role in the development of chemoresistant HCC cells and that high USP22 expression serves as a molecular marker for the prognosis of HCC patients who undergo chemotherapy.

  8. Clinical implications of thymidylate synthetase, dihydropyrimidine dehydrogenase and orotate phosphoribosyl transferase activity levels in colorectal carcinoma following radical resection and administration of adjuvant 5-FU chemotherapy

    International Nuclear Information System (INIS)

    Ishikawa, Masashi; Miyauchi, Takayuki; Kashiwagi, Yutaka

    2008-01-01

    A number of studies have investigated whether the activity levels of enzymes involved in 5-fluorouracil (5-FU) metabolism are prognostic factors for survival in patients with colorectal carcinoma. Most reports have examined thymidylate synthetase (TS) and dihydropyrimidine dehydrogenase (DPD) in unresectable or metastatic cases, therefore it is unclear whether the activity of these enzymes is of prognostic value in colorectal cancer patients treated with radical resection and adjuvant chemotherapy with 5-FU. This study examined fresh frozen specimens of colorectal carcinoma from 40 patients who had undergone curative operation and were orally administered adjuvant tegafur/uracil (UFT) chemotherapy. TS, DPD and orotate phosphoribosyl transferase (OPRT) activities were assayed in cancer tissue and adjacent normal tissue and their association with clinicopathological variables was investigated. In addition, the relationships between TS, DPD and OPRT activities and patient survival were examined to determine whether any of these enzymes could be useful prognostic factors. While there was no clear relationship between pathological findings and TS or DPD activity, OPRT activity was significantly lower in tumors with lymph node metastasis than in tumors lacking lymph node metastasis. Postoperative survival was significantly better in the groups with low TS activity and/or high OPRT activity. TS and OPRT activity levels in tumor tissue may be important prognostic factors for survival in Dukes' B and C colorectal carcinoma with radical resection and adjuvant chemotherapy with UFT

  9. Ética e profética nas Mitológicas de Lévi-Strauss

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    Renato Sztutman

    2009-06-01

    Full Text Available Este artigo intenta extrair das Mitológicas de Claude Lévi-Strauss uma ética e uma filosofia política (em princípio, ameríndias. Busca-se aqui a um só tempo responder e estender a provocação de Pierre Clastres, para quem a análise estrutural não teria se ocupado de tamanhas questões. Para realizar esta discussão, o foco será dado em duas obras de Lévi-Strauss: As origens dos modos à mesa, o terceiro volume das Mitológicas, e História de lince, a última das "pequenas mitológicas". Se a primeira finda com um excurso sobre a "moral dos mitos", a segunda principia com uma reflexão sobre a capacidade da mitologia de fornecer leituras da história, por exemplo, o "encontro" com o mundo europeu. Essas leituras, de sua parte, devem estar na base do que a literatura etnológica recente reconheceu como movimentos proféticos.This article focus Claude Lévi-Strauss' reflection on amerindian ethic and political thought. We suggest that we could read many passages of Mythologiques as if they contained sorts of replies as well as developments of some of Pierre Clastres' provocations and critics directed to structuralism. We will analyse particularly two books: Les origines des manières à table, Mythologiques' third volume, and Histoire de lynx, the last of the petites mythologiques. The first one ends with an interesting reflection on the "mythical moralism", while the second one starts with the problem of how amerindian mythologies can offer interpretations of history, interpretations of the "encounter" with europeans, for instance. These, we suppose, must be on the basis of what ethnological recent literature called "prophetic movements".

  10. El compromiso profético de los antropólogos sociales argentinos, 1960-1976

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    Rosana Guber

    2010-07-01

    Full Text Available Norbert Elias señalaba que calificar a las investigaciones según su grado de compromiso o distanciamiento de los objetos de estudio, es parte de los valores en tanto juicios prácticos que los intelectuales empleamos en el desarrollo de nuestra actividad. La profusa invocación al compromiso en la antropología latinoamerican, habla de lo que quienes lo invocan desean hacer con sus antropologías, y también de cómo este ideal nos ha modelado a los antropólogos. En este artículo muestro las formas y razones antropológicas y específicamente argentinas por las cuales la "antropología social" y el "compromiso" se constituyeron recíprocamente en el sentido común de nuestra subdisciplina en la Argentina. un doble posicionamiento-político-universitario y epistemológico-de un sector de los antropólogos argentinos que caracterizaré como profético.According to Norbert Elias, to qualify research according to its degree of commitment to, or detachment from its objects, is a practical value that intellectuals use in pursuing their job. Current references to commitment (compromiso by Latin American anthropologists, talk about those colleagues' perspectives on anthropology, and also about the ways in which such a notion has modeled them as anthropologists. Here I examine how and why Argentine anthropologists have made of "social anthropology" and "commitment" the backbone of their discipline in Argentina, both in university politics and in academic work in the 60-70s. I also suggest that anthropological debates on prophets and prophetism may cast some light upon this process.

  11. Gambaran Peningkatan Angka Kejadian Gangguan Afektif dengan Gejala Psikotik pada Pasien Rawat Inap di RSJ Prof. Dr. HB. Sa’anin Padang pada Tahun 2010 - 2011

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    Aisyah Fithri Syafwan

    2014-05-01

    Full Text Available AbstrakGangguan suasana perasaan (gangguan afektif atau mood merupakan sekelompok gambaran klinis yang ditandai dengan berkurang atau hilangnya kontrol emosi dan pengendalian diri. Gangguan afektif dapat berupa depresi, manik atau campuran keduanya (bipolar. Pada beberapa pasien gejala-gejalanya dapat disertai dengan ciri psikotik. Penelitian ini bertujuan untuk mengetahui gambaran peningkatan angka kejadian gangguan afektif dengan gejala psikotik pada pasien rawat inap di RSJ Prof. Dr. HB. Sa’anin Padang dari tahun 2010 - 2011. Penelitian ini dilakukan pada bulan Mei 2013 - Agustus 2013. Metode penelitian adalah deskriptif dengan jumlah sampel sebanyak 199 orang pada tahun 2010 dan 205 orang pada tahun 2011. Data dikumpulkan melalui bagian rekam medik RSJ Prof. Dr. HB. Sa’anin Padang dan hasil yang didapat disajikan dalam bentuk tabel distribusi frekuensi. Hasil penelitian ini menunjukkan bahwa terdapat peningkatan jumlah pasien gangguan afektif dengan gejala psikotik pada pasien rawat inap dari segi umur, jenis kelamin, pasien dari kota Padang dan luar kota Padang. Total pasien rawat inap gangguan afektif dengan gejala psikotik terhadap seluruh pasien rawat inap di RSJ Prof. Dr. HB. Sa’anin Padang adalah 31,7% (2010 dan 30% (2011 dengan usia terbanyak 20-29 tahun dan laki-laki lebih banyak daripada perempuan. Status perkawinan ditemukan kasus terbanyak pada pasien yang belum menikah dan berasal dari luar kota Padang, pekerjaan terbanyak ditemukan pada pasien yang tidak bekerja, dari segi pendidikan kasus terbanyak adalah pada SLTA-sederajat.Kata kunci: gangguan manik, gejala psikotik, gangguan depresi berat, gangguan afektif tipe campuranAbstractAffective disorder (mood disorder is group of clinical picture is characterized by reduced or loss of emotional control and self-control. Affective disorders may include depression, manic or mixture of both. In some patients the symptoms may be accompanied by psychotic featured. This study aims

  12. Therapeutic effect of intra-arterial chemotherapy with DDP and 5-FU via bilateral uterine arteries for advanced uterine cervical cancer

    International Nuclear Information System (INIS)

    Zhou Kang; Li Xiaoguang; Jin Zhengyu; Yang Ning; Liu Wei; Pan Jie; Zhang Xiaobo; Shi Haifeng; Sun Hao; Wang Zhiwei

    2010-01-01

    Objective: To evaluate the therapeutic effect of intra-arterial chemotherapy with Ddp and 5-Fu via bilateral uterine arteries for advanced uterine cervical cancer. Methods: During the period of Jan. 2006-Jan. 2009, initial intra-arterial chemotherapy by using a combination of Ddp and 5-Fu via bilateral uterine arteries was performed in 72 patients (mean age 42.9 years) with advanced uterine cervical caner. Of 72 patients, stage I b2 cervical cancer was confirmed in 28, stage II a in 12 and stage II b in 32. Pathologically, cervical squamous cell carcinoma was seen in 56 and cervical adenocarcinoma in 16 patients. Ultrasonography and physical examination were conducted both before and after intra-arterial chemotherapy. The therapeutic results,complications,the surgical resection rate and the pathologic findings were observed and statistically analyzed. Results: Fifty-four patients received one treatment course and 18 patients received two treatment courses. The over all response rate was 77.8%. The response rates of patients with I b2, II a and II b cervical cancer were 92.9%, 83.3% and 62.5% respectively, the difference between three groups was statistically significant (P < 0.05). And the response rates of patients with squamous cell carcinoma and adenocarcinoma were 85.7% and 50.0% respectively, the difference between the two was statistically significant (P < 0.05). The most common side-effects included gastrointestinal symptoms and bone marrow suppression. Thirty-four patients received radical hysterectomy,among them, 22 (78.6%) had stage I b2, 8 (66.7%) had stage II a and 4 (12.5%) had stage II b cervical cancer (P < 0.05). Pathologic exam found no vaginal invasion and ovarian metastasis in all 34 patients. The occurrence of metastasis to lymph nodes and para uterine infiltration were 17.6% and 11.8% respectively. Conclusion: Intra-arterial chemotherapy with a combination of DDP and 5-Fu via bilateral uterine arteries can safely and effectively reduce the

  13. Fußball und Identität in Israel - Die Rolle der Medien im Kontext politisch-kultureller Identitätsbildung und Ausgrenzungsprozesse

    Directory of Open Access Journals (Sweden)

    Michael Schuster

    2010-03-01

    Full Text Available Eine gängige These besagt, dass sich im Sport gesellschaftliche Konflikte widerspiegeln. Insbesondere dem Fußball wird unterstellt, eine Arena zur Artikulation und Repräsentation exklusiver Identität nationaler Minderheiten zu bieten. Der vorliegende Artikel widmet sich dem Thema der politisch-kulturellen Identitätsbildung in fragmentierten Gesellschaften. Am Beispiel der arabischen Minderheit in Israel wird dargestellt, dass unter bestimmten gesellschaftlichen Konstellationen der Fußball als Element der Popularkultur dem Staat auch als Mittel der Unterdrückung eines nationalen Minderheitenbewusstseins dienen kann. Unter Zuhilfenahme der Hegemonietheorie Antonio Gramscis kann das Entstehen einer pro-israelischen Identität der arabischen Minderheit - in Abgrenzung zu einer eigenen, arabischen oder widerständigen Identität - im Kontext des Fußballs rekonstruiert werden. Zu diesem Zweck wird aufgezeigt, welche Bedeutungs- und Definitionsmacht hebräische und arabische Sportmedien als Akteure divergierender Bedeutungszuschreibungen in dem Konfliktfeld der Herausbildung politisch-kultureller Identitäten besitzen und ihrerseits vorherrschende Integrations- und Dominanzprozesse beeinflussen. It is a widespread/popular thesis that sports are a useful means to display social conflicts; in particular it is argued that football offers a platform for the articulation and representation of the identity of ethnic/national/(cultural minorities. This article focuses on the construction of identity in fragmented societies with the help of politics and culture. With the example of the Arab minority in Israel it is portrayed here, that under particular social circumstances football can be used as an element of popular culture to repress the cultural and political identity of minorities. Gramsci's theory of hegemony explains the construction of a pro-Israel identity among the Arab minority which differs from their own Arab identity. It is shown here to

  14. A randomised placebo-exercise controlled trial of Kung Fu training for improvements in body composition in overweight/obese adolescents: the "Martial Fitness" study.

    Science.gov (United States)

    Tsang, Tracey W; Kohn, Michael; Chow, Chin Moi; Singh, M Fiatarone

    2009-01-01

    The purpose of the study was to investigate if Chinese martial arts (Kung Fu, KF) might be effective for improving body composition, as well as being an appealing form of physical activity for inexperienced, sedentary, overweight/obese adolescents. Twenty subjects (age: 13.3 ± 1.8 y; BMI percentile: 98.6(86.5 - 99.8); 60% girls) were randomly-assigned to the supervised KF or placebo (Tai Chi, TC) control group 3 d.wk(-1) for 6 months. We assessed body composition, including total and regional fat and lean mass, total and regional bone mineral density (BMD), percent lean and fat mass, body mass index and waist circumference, at baseline and after 6 months of training using anthropometry and dual-energy X-ray absorptiometry (DXA). Habitual physical activity and dietary intake were recorded as covariates via self-report at each time-point. As expected due to natural growth, significant increases in height, weight, total and lumbar BMD, and lean mass were seen in the cohort over time, with a trend for increased whole body fat mass, with no difference between groups. By contrast, percent fat and android fat mass via DXA did not increase in either group over time. The absence of a similar expected increase in central adiposity over 6 months could indicate a positive effect of participation in both programs on the metabolically critical abdominal adiposity in this cohort. Further research in this area is warranted to determine ways to increase uptake and compliance, and to see if longer-term martial arts training not only maintains, but improves abdominal fat mass and related metabolic health indices in overweight/ obese adolescents. Key pointsParticipation in our martial arts trial attenuated the increases in body fat mass expected due to growth in our overweight/obese adolescent group.All subjects allocated to the Kung Fu intervention were satisfied with their Kung Fu training, in contrast to our placebo-exercise (Tai Chi) subjects, suggesting that this form of

  15. Rao, Prof. Sumathi

    Indian Academy of Sciences (India)

    Ethical Guidelines and Procedures document. Posted on 17 January 2017. A revised version of the document 'Scientific Values: Ethical Guidelines and Procedures' has been produced by the Academy's Panel on Scientific Values. For more details, see the Academy Committee on Scientific Values page.

  16. Kulkarni, Prof. Sulabha Kashinath

    Indian Academy of Sciences (India)

    Ethical Guidelines and Procedures document. Posted on 17 January 2017. A revised version of the document 'Scientific Values: Ethical Guidelines and Procedures' has been produced by the Academy's Panel on Scientific Values. For more details, see the Academy Committee on Scientific Values page.

  17. Chaudhuri, Prof. Mihir Kanti

    Indian Academy of Sciences (India)

    ... Synthesis, Structure & Reactivity, Newer Reagents and Methodologies and Green Chemical Technology Address: Adviser (Education), Government of Assam, Sachivalaya, Dispur, Guwahati 781 006, Assam Contact: Mobile: 99544 49454

  18. Agrawal, Prof. Manindra

    Indian Academy of Sciences (India)

    Elected: 2004 Section: Engineering & Technology ... Department of Computer Science, Indian Institute of Technology, Kanpur 208 016, U.P. ... Mobile: 99350 62605 ... Math Art and Design: MAD about Math, Math Education and Outreach.

  19. About Prof. Satish Dhawan

    Indian Academy of Sciences (India)

    It is easy to say that space can ... Dhawan was a person who could think well ahead. It was his strategic decision .... the work horse launch vehicle of ISRO today, with six successful flights so far. ... highly committed and talented people. He was ...

  20. Kapuria, Prof. Santosh

    Indian Academy of Sciences (India)

    IIT, Delhi), FNA, FNAE, FNASc. Date of birth: 22 February 1968. Specialization: Structural Mechanics, Multi-Functional Structures, Structural Health Monitoring Address: Director, Structural Engineering Research Centre, CSIR Road, Taramani, ...

  1. Ghosh, Prof. Anish

    Indian Academy of Sciences (India)

    Brandeis). Date of birth: 25 December 1979. Specialization: Ergodic Theory, Lie Groups, Number Theory Address: School of Mathematics, Tata Institute of Fundamental Research, Homi Bhabha Road, Mumbai 400 005, Maharashtra Contact:

  2. Mukhopadhyaya, Prof. Biswarup

    Indian Academy of Sciences (India)

    , FNASc. Date of birth: 1 August 1960. Specialization: Theoretical High Energy Physics, Collider Physics, Neutrino & Higgs Physics Address: Harish Chandra Research Institute, Chhatnag Road, Jhusi, Allahabad 211 019, U.P.. Contact:

  3. Madyastha, Prof. Kattigari Madhava

    Indian Academy of Sciences (India)

    Pune), FNASc. Date of birth: 22 July 1937. Specialization: Bio-organic Chemistry, Xenobiotics Metabolism, Plant Biochemistry and Microbial Transformations Address: 162, Srikrishna, 5th Main, 4th Cross, NGEF Layout, Sanjay Nagar, Bengaluru ...

  4. Savithri, Prof. Handanahal Subbarao

    Indian Academy of Sciences (India)

    Date of birth: 18 March 1951. Specialization: Plant Molecular Virology, Protein Chemistry, and Enzymology Address: INSA Senior Scientist, Department of Biochemistry, Indian Institute of Science, Bengaluru 560 012, Karnataka Contact: Office: (080) 2360 1561, (080) 2293 2310. Residence: (080) 2337 2981. Mobile: 94483 ...

  5. Prasad, Prof. Surendra

    Indian Academy of Sciences (India)

    Date of birth: 10 July 1948. Specialization: Signal Processing, Communication Theory and Systems Address: Emeritus Professor, Department of Electrical Engineering, Indian Institute of Technology, Hauz Khas, New Delhi 110 016, U.T.. Contact: Office: (011) 2659 6201, (011) 2659 1115. Residence: (0124) 406 7489

  6. Chakravarty, Prof. Charusita

    Indian Academy of Sciences (India)

    Ethical Guidelines and Procedures document. Posted on 17 January 2017. A revised version of the document 'Scientific Values: Ethical Guidelines and Procedures' has been produced by the Academy's Panel on Scientific Values. For more details, see the Academy Committee on Scientific Values page.

  7. Gavai, Prof. Rajiv Vasantrao

    Indian Academy of Sciences (India)

    Specialization: High Energy Physics, Quantum Field Theory, Lattice Field Theories, Quark-Gluon Plasma, and Relativistic Heavy Ion Collisions and Early Universe Address: Senior Professor, Theoretical Physics Department, Tata Institute of Fundamental Research, Homi Bhabha Road, Mumbai 400 005, Maharashtra

  8. Chauhan, Prof. Virander Singh

    Indian Academy of Sciences (India)

    Virander Singh Ph.D. (Delhi), D.Phil. (Oxford), FNA, FNASc. Date of birth: 3 March 1950. Specialization: Peptide Synthesis & Structure, Malaria Immunology and Malaria Drug Development, Biomarker Discovery Address: Visiting Scientist, International Centre for Genetic Engineering & Biotechnology, NII Campus, Aruna Asaf ...

  9. Biswas, Prof. Birendra Bijoy

    Indian Academy of Sciences (India)

    Calcutta), FNA. Date of birth: 1 March 1928. Specialization: Nucleic Acid Metabolism, Plant Biochemistry and Genetic Engineering Address: CG-155, Salt Lake City, Kolkata 700 091, W.B.. Contact: Residence: (033) 2334 8649. Mobile: 94334 24609

  10. Periasamy, Prof. Mariappan

    Indian Academy of Sciences (India)

    D. (IISc), FNA. Date of birth: 6 October 1952. Specialization: Organometallics, Chiral Reagents, Organic Molecules, Solar Energy Harvesting Address: Emeritus Professor, School of Chemistry, University of Hyderabad, Hyderabad 500 046, A.P.

  11. Natarajan, Prof. Kootalai Ananthaiyer

    Indian Academy of Sciences (India)

    Elected: 1993 Section: Engineering & Technology ... Address: NASI Honorary Scientist & Platinum Jubilee Fellow, Department of Materials Engineering, Indian Institute of Science, Bengaluru 560 012, ... Upcoming Refresher Courses.

  12. Chaudhuri, Prof. Subhasis

    Indian Academy of Sciences (India)

    Elected: 2005 Section: Engineering & Technology ... Address: KN Bajaj Chair Professor, Dept. of Electrical Engineering, Indian Institute of Technology, Powai, Mumbai 400 076, Maharashtra Contact: ... Upcoming Refresher Courses. Topology

  13. Kaul, Prof. Sharika Nandan

    Indian Academy of Sciences (India)

    Date of birth: 4 August 1949. Specialization: Condensed Matter Physics, Phase Transitions & Critical Phenomena, Disordered Systems Percolation and Magnetism & Magnetic Materials, Physics at Nanometer Length Scale Address: INSA Senior Scientist, School of Physics, University of Hyderabad, Hyderabad 500 046, ...

  14. Prof. Yash Pal

    Indian Academy of Sciences (India)

    Date of birth: 26 November 1926. Date of death: 24 July 2017. Specialization: Physics, Astrophysics, Space Technology and Communications Last known address: 11B, Super Delux Flats, Sector 15A, Noida 201 301, U.P.. YouTube; Twitter; Facebook; Blog ...

  15. Goswami, Prof. Bhupendra Nath

    Indian Academy of Sciences (India)

    Bhupendra Nath Ph.D. (Gujarat), FNASc, FNA, FTWAS Council Service: 2010-12. Date of birth: 1 August 1950. Specialization: Tropical Meteorology, Monsoon Dynamics, Predictability of Weather & Climate and Air-Sea Interactions Address: INSA Senior Scientist, Department of Physics, Cotton University, Guwahati 781 001, ...

  16. Majumder, Prof. Partha Pratim

    Indian Academy of Sciences (India)

    Date of birth: 6 September 1952. Specialization: Biostatistics, Human Genetics and Population Genetics Address: Distinguished Professor, National Institute of Biomedical Genomics, Post Netaji Subhas Sanitorium, Kalyani 741 251, W.B.. Contact: Office: (033) 2589 2150-51. Residence: (033) 2565 4314

  17. Ramaraj, Prof. Ramasamy

    Indian Academy of Sciences (India)

    Ramasamy Ph.D. (Madras), D.Sc. (Japan), D.Sc. (MKU), FNASc, FNA. Date of birth: 8 March 1956. Specialization: Photoelectrocatalysis & Nanomaterials, Chemically Modified Electrodes, Solar Energy Conversion, Catalysis and Sensors Address: CSIR Emeritus Scientist, School of Chemistry, Madurai Kamaraj University, ...

  18. Mukhi, Prof. Sunil

    Indian Academy of Sciences (India)

    Date of birth: 20 November 1956. Specialization: String Theory, Quantum Gravity, Supersymmetry Address: Chair, Physics Programme, Indian Institute of Science Education & Research, Dr Homi Bhabha Road, Pashan, Pune 411 008, Maharashtra Contact: Office: (020) 2590 6118. Mobile: 98672 01156. Fax: (020) 2586 ...

  19. Mahadevan, Prof. Subramony

    Indian Academy of Sciences (India)

    Date of birth: 7 November 1953. Specialization: Regulation of Gene Expression in Bacteria, Microbial Physiology and Microbial Evolution Address: Professor, Department of Molecular Reproduction, Development, and Genetics, Indian Institute of Science, Bengaluru 560 012, Karnataka Contact: Office: (080) 2293 2607

  20. Deb, Prof. Bidyendu Mohan

    Indian Academy of Sciences (India)

    Bidyendu Mohan D.Phil. (Oxon), FNA, FTWAS Council Service: 1995-2000. Date of birth: 27 September 1942. Specialization: Theoretical Chemistry and Chemical Physics, Indian Culture & Civilisation Address: INSA Senior Scientist, Publishing Department, Visva Bharati University, 6A, JC Bose Road, Kolkata 700 017, W.B.

  1. Yathindra, Prof. Narayanarao

    Indian Academy of Sciences (India)

    Narayanarao Ph.D. (Madras). Date of birth: 12 March 1944. Specialization: Computational Structural Biology Address: Director, Institute of Bioinformatics and Applied Biotechnology, Biotech Park (Next to Arvind Mills), Electronic City, Phase 1 (Behind 3M), Bengaluru 560 100, Karnataka Contact: Office: (080) 2852 8900-03

  2. Prof. Narendra Kumar

    Indian Academy of Sciences (India)

    ... Stochastic Transport Processes & Statistical Physics, High Temperature Superconductivity and Localization in Disordered Systems Last known address: Emeritus Professor, Raman Research Institute, CV Raman Avenue, Bengaluru 560 080, Karnataka. http://www.rri.res.in/~nkumar · YouTube; Twitter; Facebook; Blog ...

  3. Dhar, Prof. Deepak

    Indian Academy of Sciences (India)

    Specialization: Statistical Physics and Stochastic Processes Address: Theoretical Physics Group, Indian Institute of Science Education & Research, Pashan, Pune 411 008, Maharashtra Contact: Residence: (020) 2590 8455. Mobile: 75069 46612. Email: deepakdhar1951@gmail.com. YouTube; Twitter; Facebook; Blog ...

  4. Muralidhar, Prof. Kambadur

    Indian Academy of Sciences (India)

    Date of birth: 25 December 1948. Specialization: Biochemistry, Endocrinology and Reproductive Biology Address: School of Life Sciences, University of Hyderabad, Hyderabad 500 046, A.P.. Contact: Mobile: 98109 27705. Email: kambadur2015@gmail.com, kambadurmurali2001@rediffmail.com. YouTube; Twitter ...

  5. Prasad, Prof. Gopal

    Indian Academy of Sciences (India)

    Specialization: Lie Groups and Algebraic Groups Address: Raoul Bott Emeritus Professor of Mathematics, The University of Michigan, Ann Arbor, Michigan 48109-1043, USA Contact: Office: (+1-734) 764 0372. Residence: (+1-734) 585 5487. Fax: (+1-734) 763 0937. Email: gprasad@umich.edu. YouTube; Twitter; Facebook ...

  6. Raju, Prof. Trichur Ramaswamy

    Indian Academy of Sciences (India)

    Trichur Ramaswamy Ph.D. (ANU). Date of birth: 31 March 1952. Specialization: Developmental Neuroscience, Neurodegeneration and Neuronal Plasticity Address: Senior Professor, Department of Neurophysiology, National Institute of Mental Health & Neurosciences, P.B. No. 2900, Bengaluru 560 029, Karnataka Contact:

  7. Deshpande, Prof. Suresh Madhusudhan

    Indian Academy of Sciences (India)

    ... Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur, Bengaluru 560 064, Karnataka Contact: Office: (080) 2208 2861. Residence: (080) 2341 2029. Mobile: 94484 71243. Fax: (080) 2208 2766. Email: smd@jncasr.ac.in, desh1942@gmail.com. http://www.jncasr.ac.in/smd/ · YouTube · Twitter · Facebook ...

  8. Udgaonkar, Prof. Jayant Bhalchandra

    Indian Academy of Sciences (India)

    Date of birth: 22 March 1960. Specialization: Physical Biochemistry and Protein Folding Address: Director, Indian Institute of Science Education and Research, Homi Bhabha Road, Pashan, Pune 411 008, Maharashtra Contact: Office: (020) 2590 8000. Email: director@iiserpune.ac.in. YouTube; Twitter; Facebook; Blog ...

  9. Anupama, Prof. Gadiyara Chakrapani

    Indian Academy of Sciences (India)

    Specialization: Time Domain Astronomy, Cataclysmic Variables, Supernovae, Gamma-Ray Burst Sources, Active Galactic Nuclei Address: Senior Professor, Indian Institute of Astrophysics, Sarjapur Road, Koramangala, Bengaluru 560 034, Karnataka Contact: Office: (080) 2254 1344. Residence: (080) 6697 3104

  10. Narlikar, Prof. Anant Vishnu

    Indian Academy of Sciences (India)

    Date of birth: 31 March 1940. Specialization: Superconductivity, Low Temperature Physics and STM & Related Techniques Address: INSA Senior Scientist & Visiting Fellow, UGC-DAE Consortium for Scientific Research, University Campus, Khandwa Road, Indore 452 017, M.P.. Contact: Office: (0731) 246 3913. Residence: ...

  11. Palis, Prof. Jacob

    Indian Academy of Sciences (India)

    Date of birth: 15 March 1940. Address: Instituto de Matematica Pura e, Aplicada - IMPA, Estrada Dona Castorina 110, Jardim Botanico, 22460-320 Rio de Janeiro, Brazil Contact: Office: (+55-21) 2529 5136. Residence: (+55-21) 2537 3272. Fax: (+55-21) 2529 5019. Email: jpalis@impa.br. YouTube; Twitter; Facebook; Blog ...

  12. Gopinath, Prof. Gomathy

    Indian Academy of Sciences (India)

    Anat.) (AIIMS), FAMS, FNASc. Date of birth: 24 January 1940. Specialization: Developmental Neurobiology, Environment & Neural Plasticity and Neural Transplantation Address: Flat No. 001, Kanchanjunga Apartments, 122/2, Nagavarapalya, CV ...

  13. Krishnaswamy, Prof. Kamala

    Indian Academy of Sciences (India)

    Date of birth: 4 April 1940. Specialization: Internal Medicine, Nutritional Sciences and Clinical Pharmacokinetics Address: Sriniketan, No. 1-2-98/2, Kakatiyanagar Colony, Habsiguda, Hyderabad 500 007, A.P.. Contact: Residence: (040) 2715 3248. Mobile: 98662 35238. Email: sri21kk@hotmail.com, sri21kk@yahoo.com.

  14. Ghosh, Prof. Subrata

    Indian Academy of Sciences (India)

    Date of birth: 8 April 1950. Specialization: Cycloaddition Reactions and Total Synthesis of Natural Products Address: INSA Senior Scientist, Department of Organic Chemistry, Indian Association for the Cultivation of Science, Jadavpur, Kolkata 700 032, W.B.. Contact: Office: (033) 2473 4971/1402. Residence: (033) 2425 ...

  15. Natarajan, Prof. Srinivasan

    Indian Academy of Sciences (India)

    D. (IIT, Madras), FNASc, FNA. Date of birth: 27 May 1960. Specialization: Inorganic Materials Chemistry and Solid State Chemistry Address: Solid State & Structural Chemistry Unit, Indian Institute of Science, Bengaluru 560 012, Karnataka

  16. Khurana, Prof. Jitendra Paul

    Indian Academy of Sciences (India)

    Date of birth: 30 October 1954. Specialization: Photoperception & Signal Transduction in Plants, Structural & Functional Genomics and Plant Hormone Action Address: Department of Plant Molecular Biology, University of Delhi South Campus, Benito Juarez Road, New Delhi 110 021, U.T.. Contact: Office: (011) 2411 5126

  17. Ananthakrishnan, Prof. Subramaniam

    Indian Academy of Sciences (India)

    Date of birth: 14 May 1944. Specialization: Radio Sciences, Extragalactic Radio Astronomy, Sun & Solar Wind, Antennas, Interferometry Techniques and Analog RF Electronics Address: Adjunct Professor & INSA Honorary Scientist, Electronic Science Department, Pune University, Ganeshkhind, Pune 411 007, Maharashtra

  18. Sharma, Prof. Anurag

    Indian Academy of Sciences (India)

    Elected: 2002 Section: Engineering & Technology ... Address: Professor, Department of Physics, Indian Institute of Technology, New Delhi 110 ... Mobile: 98183 55884 ... Math Art and Design: MAD about Math, Math Education and Outreach.

  19. Sen, Prof. Kalidas

    Indian Academy of Sciences (India)

    Specialization: Quantum Model Potentials, Density Functional Theory, Confined Systems, Information Theory, Statistical Complexity Address: ... Joint Statement by the Three Science Academies of India on the teaching of the theory of evolution

  20. Nangia, Prof. Ashwini

    Indian Academy of Sciences (India)

    . Ashwini Ph.D. (Yale), FRSC, FNA, FNASc. Date of birth: 10 November 1960. Specialization: Crystal Engineering, Supramolecular Chemistry and Polymorphism Address: School of Chemistry, University of Hyderabad, Hyderabad 500 046, A.P.

  1. Dutta Gupta, Prof. Aparna

    Indian Academy of Sciences (India)

    Specialization: Insect Molecular Physiology, Integrated Insect Pest Management, Comparative Physiology, Endocrinology Address: Department of Animal Biology, School of Life Sciences, University of Hyderabad, Hyderabad 500 046, A.P.. Contact: Office: (040) 2313 4560. Residence: 78930 46218. Mobile: 93910 74729

  2. Goswami, Prof. Srubabati

    Indian Academy of Sciences (India)

    ... March 1966. Specialization: High Energy Physics, Astroparticle Physics, Neutrino Physics Address: Physical Research Laboratory, Navrangpura, Ahmedabad 380 009, Gujarat Contact: Office: (079) 2631 4471. Residence: (079) 2686 0072. Mobile: 99099 06086. Email: srub@prl.res.in. YouTube; Twitter; Facebook; Blog ...

  3. Mugesh, Prof. Govindasamy

    Indian Academy of Sciences (India)

    D. (IIT, Bombay), FNASc, FNA, FRSC. Date of birth: 29 May 1970. Specialization: Bioinorganic Chemistry, Chemical Biology, Medicinal Chemistry Address: Department of Inorganic & Physical Chemistry, Indian Institute of Science, Bengaluru ...

  4. Panda, Prof. Sudhakar

    Indian Academy of Sciences (India)

    Date of birth: 23 February 1959. Specialization: High Energy Physics, String Theory, Cosmology, Quantum Field Theory Address: Director, Institute of Physics, Sachivalaya Marg, Bhubaneswar 751 005, Orissa Contact: Office: (0674) 230 1825, 230 6404. Residence: (0674) 230 1367, 230 6601. Mobile: 94375 59215

  5. Borges, Prof. Renee M

    Indian Academy of Sciences (India)

    Specialization: Evolutionary Biology & Behavioural Ecology, Plant-Animal ... Joint Statement by the Three Science Academies of India on the teaching of the theory of evolution more. ... Biotechnology techniques in Biodiversity conservation

  6. Aggarwal, Prof. Amita

    Indian Academy of Sciences (India)

    Lucknow), FNASc, FAMS. Date of birth: 31 December 1960. Specialization: Clinical Immunology, Rheumatology, Juvenile Arthritis Address: Department of Clinical Immunology, Sanjay Gandhi PG Institute of Medical Sciences, Lucknow 226 014, U.P.

  7. Chatterjee, Prof. Mitali

    Indian Academy of Sciences (India)

    Jadavpur), FNASc, FRCP (London). Date of birth: 2 November 1960. Specialization: Pharmacology, Immunology, Parasitology Address: Department of Pharmacology, Institute of PG Medical Education & Research, 244-B, Acharya JC Bose Road, ...

  8. Mukund, Prof. Madhavan

    Indian Academy of Sciences (India)

    : Chennai Mathematical Institute, H1, SIPCOT IT Park, Siruseri, Kelambakkam, Chennai 603 103, T.N.. Contact: Office: (044) 6748 0923. Residence: (044) 2457 0321. Mobile: 94449 92990. Fax: (044) 2747 0225. Email: madhavan@cmi.ac.in.

  9. Umapathy, Prof. Siva

    Indian Academy of Sciences (India)

    Otago, New Zealand). Date of birth: 10 June 1959. Specialization: Instrumentation Development, Microspectroscopy, Laser Spectroscopy, Photochemistry and Ultrafast Dynamics Address: Professor, Department of Inorganic & Physical, Chemistry, ...

  10. Nagakura, Prof. Saburo

    Indian Academy of Sciences (India)

    Date of birth: 3 October 1920. Address: President, The Japan Academy, 7-32, Ueno Park, Taito-ku, Tokyo 110-0007, Japan Contact: Office: (+81-3) 3822 2101. Fax: (+81-3) 3822 2105. YouTube; Twitter; Facebook; Blog. Academy News. IAS Logo. 29th Mid-year meeting. Posted on 19 January 2018. The 29th Mid-year ...

  11. Goswami, Prof. Ravinder

    Indian Academy of Sciences (India)

    Specialization: Autoimmune Endocrine Disorders, Sporadic Idiopathic Hypoparathyroidism and Metabolic Bone Disorders including Vitamin D Deficiency Address: Department of Endocrinology & Metabolism, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110 029, U.T.. Contact: Office: (011) 2659 4272

  12. Vijayan, Prof. Mamannamana

    Indian Academy of Sciences (India)

    : 1989-94; 2001-2003. Date of birth: 16 October 1941. Specialization: X-ray Crystal Structure Analysis, Protein & Crystallography and Molecular Biophysics Address: INSA Albert Einstein Professor, Molecular Biophysics Unit, Indian Institute of ...

  13. Pati, Prof. Arun Kumar

    Indian Academy of Sciences (India)

    Specialization: Quantum Information Theory, Quantum Computing, Foundations of Quantum Theory Address: QIC Group, Physics Division, Harish Chandra Research Institute, Chhatnag Road, Jhusi, Allahabad 211 019, U.P.. Contact: Office: (0532) 227 4391. Mobile: 87566 12314. Fax: (0532) 256 9576, (0532) 256 7444

  14. Kaw, Prof. Predhiman Krishan

    Indian Academy of Sciences (India)

    Ph.D. (IIT, Delhi), FNA, FNASc. Date of birth: 15 January 1948. Date of death: 18 June 2017. Specialization: Plasma Physics Last known address: DST Year of Science Chair professor, Institute for Plasma Research, Bhat, Gandhinagar 382 428, Gujarat. http://www.ipr.res.in/~theory/kaw_sir_home_page/kaw.htm · YouTube ...

  15. Mandal, Prof. Gautam

    Indian Academy of Sciences (India)

    ), FNA. Date of birth: 15 December 1962. Specialization: Quantum Field Theory, Gravity, String Theory Address: Department of Theoretical Physics, Tata Institute of Fundamental Research, Homi Bhabha Road, Mumbai 400 005, Maharashtra

  16. Ranganathan, Prof. Srinivasa

    Indian Academy of Sciences (India)

    , Art & Technology Interactions Address: NASI Platinum Jubilee Senior Scientist, Department of Materials Engineering, Indian Institute of Science, Bengaluru 560 012, Karnataka Contact: Office: (080) 2360 1198. Residence: (080) 2351 8521

  17. Ananthakrishna, Prof. Garani

    Indian Academy of Sciences (India)

    Date of birth: 11 December 1942. Specialization: Theoretical Materials Science, Condensed Matter and Dynamical Systems & Chaos Address: Materials Research Centre, Indian Institute of Science, Bengaluru 560 012, Karnataka Contact: Office: (080) 2293 2780. Residence: (080) 4953 5791. Mobile: 99002 68902

  18. Sen, Prof. Diptiman

    Indian Academy of Sciences (India)

    Princeton), FNA, FNASc. Date of birth: 17 January 1959. Specialization: Theoretical Condensed Matter Physics and Quantum Field Theory Address: Professor, Centre for High Energy Physics, Indian Institute of Science, Bengaluru 560 012, Karnataka

  19. Maheshwari, Prof. Satish Chandra

    Indian Academy of Sciences (India)

    Delhi), FNA, FNASc. Date of birth: 4 October 1933. Specialization: Physiology & Biochemistry of Plant Growth & Development and Plant Molecular Biology Address: 251/56, Prathap Enclave, Haldighati Road, Jaipur 302 033, Rajasthan Contact ...

  20. Ramakrishnan, Prof. Tiruppattur Venkatachalamurti

    Indian Academy of Sciences (India)

    Date of birth: 14 August 1941. Specialization: Condensed Matter Physics and Statistical Mechanics Address: Emeritus Professor, Department of Physics, Banaras Hindu University, Varanasi 221 005, U.P.. Contact: Office: (0542) 230 7327. Residence: (0542) 236 7008, (080) 6535 9939. Mobile: 94483 63379. Fax: (0542) ...