WorldWideScience

Sample records for productions complex located

  1. Appropriate location of the nipple-areola complex in males.

    Science.gov (United States)

    Shulman, O; Badani, E; Wolf, Y; Hauben, D J

    2001-08-01

    Gynecomastia is a common deformity encountered by plastic surgeons. The appropriate location of the nipple-areola complex is a major determinant of the aesthetic success of the procedure. To study the natural location of the nipple-areola complex in the normally built male, 50 nonobese men with no evidence of gynecomastia and an average age of 27.9 years were examined. Three ratios were calculated and found to be relatively constant; they were the ratio between the height of the nipple and the height of the patient, the ratio between the distance between the nipples and chest circumference, and the ratio between the suprasternal notch-to-nipple distance and the height of the patient. Using these three parameters, a method of locating the nipple-areola complex on the male chest wall was devised. The method is advocated as a reliable, simple, and useful technique.

  2. Knowledge Production, Urban Locations and the Importance of Local Networks

    DEFF Research Database (Denmark)

    Skytt-Larsen, Christine Benna; Winther, Lars

    2015-01-01

    This paper analyses the relationship between knowledge production and urban locations in industrial design, a knowledge-intensive business service (KIBS). KIBS concentrate in urban locations. This is often explained by the co-location of client firms and market access in large cities. Recent...... research on knowledge production, however, reveals that knowledge productive networks are significant for both the competitiveness and location of KIBS. Thus, to understand the urban location of industrial design, it is important to analyse how knowledge production is organized within the industry....... Industrial design is concentrated in urban locations, but most of its clients are located elsewhere. Hence, it seems that industrial design firms concentrate in urban locations mainly because their knowledge networks include specific types of formal and informal local social networks....

  3. A heuristic algorithm for a multi-product four-layer capacitated location-routing problem

    Directory of Open Access Journals (Sweden)

    Mohsen Hamidi

    2014-01-01

    Full Text Available The purpose of this study is to solve a complex multi-product four-layer capacitated location-routing problem (LRP in which two specific constraints are taken into account: 1 plants have limited production capacity, and 2 central depots have limited capacity for storing and transshipping products. The LRP represents a multi-product four-layer distribution network that consists of plants, central depots, regional depots, and customers. A heuristic algorithm is developed to solve the four-layer LRP. The heuristic uses GRASP (Greedy Randomized Adaptive Search Procedure and two probabilistic tabu search strategies of intensification and diversification to tackle the problem. Results show that the heuristic solves the problem effectively.

  4. Locating the source of diffusion in complex networks by time-reversal backward spreading

    Science.gov (United States)

    Shen, Zhesi; Cao, Shinan; Wang, Wen-Xu; Di, Zengru; Stanley, H. Eugene

    2016-03-01

    Locating the source that triggers a dynamical process is a fundamental but challenging problem in complex networks, ranging from epidemic spreading in society and on the Internet to cancer metastasis in the human body. An accurate localization of the source is inherently limited by our ability to simultaneously access the information of all nodes in a large-scale complex network. This thus raises two critical questions: how do we locate the source from incomplete information and can we achieve full localization of sources at any possible location from a given set of observable nodes. Here we develop a time-reversal backward spreading algorithm to locate the source of a diffusion-like process efficiently and propose a general locatability condition. We test the algorithm by employing epidemic spreading and consensus dynamics as typical dynamical processes and apply it to the H1N1 pandemic in China. We find that the sources can be precisely located in arbitrary networks insofar as the locatability condition is assured. Our tools greatly improve our ability to locate the source of diffusion in complex networks based on limited accessibility of nodal information. Moreover, they have implications for controlling a variety of dynamical processes taking place on complex networks, such as inhibiting epidemics, slowing the spread of rumors, pollution control, and environmental protection.

  5. Tensor Product of Polygonal Cell Complexes

    OpenAIRE

    Chien, Yu-Yen

    2017-01-01

    We introduce the tensor product of polygonal cell complexes, which interacts nicely with the tensor product of link graphs of complexes. We also develop the unique factorization property of polygonal cell complexes with respect to the tensor product, and study the symmetries of tensor products of polygonal cell complexes.

  6. Spatial competition for biogas production using insights from retail location models

    DEFF Research Database (Denmark)

    Bojesen, Mikkel; Birkin, M.; Clarke, G.

    2014-01-01

    production sector. Through a two-step approach by combining a location-allocation model with a production constrained spatial interaction model, this paper addresses the dual problem of determining optimal location and production capacity. What-if scenarios, in combination with the strategic economic...

  7. Perspectives on Spatial Decision Support Concerning Location of Biogas Production

    DEFF Research Database (Denmark)

    Bojesen, Mikkel

    in biogas production. This ambition requires that more than 20 new large scale centralised biogas plants are built. The location of these plants is associated with a number of externalities and uncertainties and the existing biogas sector struggles to establish itself as a viable energy producing sector....... Meanwhile planners and decision makers struggle to find sustainable locations that comprehensively balance the multiple concerns the location of biogas facilities includes. This PhD project examines how spatial decision support models can be used to ensure sustainable locations of future biogas plants......, understand the industrial economic aspects of such a role. Through the use of spatial multi-criteria evaluation models stakeholder preferences to decision criteria are included in a sustainable biogas facility location analysis. By the use of these models it is demonstrated how overall biogas production...

  8. Harnessing Product Complexity: An Integrative Approach

    OpenAIRE

    Orfi, Nihal Mohamed Sherif

    2011-01-01

    In today's market, companies are faced with pressure to increase variety in product offerings. While increasing variety can help increase market share and sales growth, the costs of doing so can be significant. Ultimately, variety causes complexity in products and processes to soar, which negatively impacts product development, quality, production scheduling, efficiency and more. Product variety is just one common cause of product complexity, a topic that several researchers have tackled with...

  9. Product development projects dynamics and emergent complexity

    CERN Document Server

    Schlick, Christopher

    2016-01-01

    This book primarily explores two topics: the representation of simultaneous, cooperative work processes in product development projects with the help of statistical models, and the assessment of their emergent complexity using a metric from theoretical physics (Effective Measure Complexity, EMC). It is intended to promote more effective management of development projects by shifting the focus from the structural complexity of the product being developed to the dynamic complexity of the development processes involved. The book is divided into four main parts, the first of which provides an introduction to vector autoregression models, periodic vector autoregression models and linear dynamical systems for modeling cooperative work in product development projects. The second part presents theoretical approaches for assessing complexity in the product development environment, while the third highlights and explains closed-form solutions for the complexity metric EMC for vector autoregression models and linear dyn...

  10. Suppression of grasshopper sound production by nitric oxide-releasing neurons of the central complex

    Science.gov (United States)

    Weinrich, Anja; Kunst, Michael; Wirmer, Andrea; Holstein, Gay R.

    2008-01-01

    The central complex of acridid grasshoppers integrates sensory information pertinent to reproduction-related acoustic communication. Activation of nitric oxide (NO)/cyclic GMP-signaling by injection of NO donors into the central complex of restrained Chorthippus biguttulus females suppresses muscarine-stimulated sound production. In contrast, sound production is released by aminoguanidine (AG)-mediated inhibition of nitric oxide synthase (NOS) in the central body, suggesting a basal release of NO that suppresses singing in this situation. Using anti-citrulline immunocytochemistry to detect recent NO production, subtypes of columnar neurons with somata located in the pars intercerebralis and tangential neurons with somata in the ventro-median protocerebrum were distinctly labeled. Their arborizations in the central body upper division overlap with expression patterns for NOS and with the site of injection where NO donors suppress sound production. Systemic application of AG increases the responsiveness of unrestrained females to male calling songs. Identical treatment with the NOS inhibitor that increased male song-stimulated sound production in females induced a marked reduction of citrulline accumulation in central complex columnar and tangential neurons. We conclude that behavioral situations that are unfavorable for sound production (like being restrained) activate NOS-expressing central body neurons to release NO and elevate the behavioral threshold for sound production in female grasshoppers. PMID:18574586

  11. Product variety, product complexity and manufacturing operational performance: A systematic literature review

    DEFF Research Database (Denmark)

    Trattner, Alexandria Lee; Hvam, Lars; Herbert-Hansen, Zaza Nadja Lee

    Manufacturing in the twenty-first century has been wrought with the struggle to satisfy the rising demand for greater product variety and more complex products while still maintaining efficient manufacturing operations. However, the literature lacks an overview of which operational performance...... measures are most affected by increased variety and complexity. This study presents a systematic literature review of the recent scholarly literature on variety, complexity and manufacturing operational performance (MOP). Results show that product variety has a consistently negative relationship with MOP...... across different time, cost, quality and flexibility measures while product complexity lacks evidence of strong relationships with MOP measures....

  12. Validation of Product Properties Considering a High Variety of Complex Products

    OpenAIRE

    Kortler, S.;Kohn, A.;Lindemann, U.

    2017-01-01

    Validation processes are becoming more and more complex. Due to rising technical capabilities and a wide variety of customer requirements, OEMs are increasing their product variety in order to increase profits. According to the various characteristics of subcontracted components involved in complex products, the product variety can be very high. The impacts of the involved subcontracted components on the composed product variety during the product’s application are difficult to predict. This ...

  13. The location and recognition of anti-counterfeiting code image with complex background

    Science.gov (United States)

    Ni, Jing; Liu, Quan; Lou, Ping; Han, Ping

    2017-07-01

    The order of cigarette market is a key issue in the tobacco business system. The anti-counterfeiting code, as a kind of effective anti-counterfeiting technology, can identify counterfeit goods, and effectively maintain the normal order of market and consumers' rights and interests. There are complex backgrounds, light interference and other problems in the anti-counterfeiting code images obtained by the tobacco recognizer. To solve these problems, the paper proposes a locating method based on Susan operator, combined with sliding window and line scanning,. In order to reduce the interference of background and noise, we extract the red component of the image and convert the color image into gray image. For the confusing characters, recognition results correction based on the template matching method has been adopted to improve the recognition rate. In this method, the anti-counterfeiting code can be located and recognized correctly in the image with complex background. The experiment results show the effectiveness and feasibility of the approach.

  14. Identification and location of catenary insulator in complex background based on machine vision

    Science.gov (United States)

    Yao, Xiaotong; Pan, Yingli; Liu, Li; Cheng, Xiao

    2018-04-01

    It is an important premise to locate insulator precisely for fault detection. Current location algorithms for insulator under catenary checking images are not accurate, a target recognition and localization method based on binocular vision combined with SURF features is proposed. First of all, because of the location of the insulator in complex environment, using SURF features to achieve the coarse positioning of target recognition; then Using binocular vision principle to calculate the 3D coordinates of the object which has been coarsely located, realization of target object recognition and fine location; Finally, Finally, the key is to preserve the 3D coordinate of the object's center of mass, transfer to the inspection robot to control the detection position of the robot. Experimental results demonstrate that the proposed method has better recognition efficiency and accuracy, can successfully identify the target and has a define application value.

  15. Production design and location in the Danish television drama series Arvingerne

    DEFF Research Database (Denmark)

    Ion Wille, Jakob; Waade, Anne Marit

    2016-01-01

    Television fiction is most often referred to as the writer’s medium, whereas feature film is generally perceived as the vision and work of the director. In this article we turn our focus to the role and function of the production design and locations in developing and conceptualising a television...... drama series. We use the drama series Arvingerne (The Legacy, DR, 2014-2015) to illustrate how design ideas can be developed at an early stage, in pre-pre-production, as part of a collective, creative process that includes the scriptwriter, the production designer and the producer. Our empirical study...... of the series draws on an analysis of in-house design/concept documents [1], interviews with the production designer Mia Stensgaard [2], and promotional material made for the series [3]. The paper also draws on visual analysis of the finished production. Our overall argument is that the importance of location...

  16. The “Weight” of Product Claims and Vertical Location

    DEFF Research Database (Denmark)

    Festila, Alexandra; Chrysochou, Polymeros

    The present research shows that claims denoting healthy attributes will elicit more favorable consumer evaluations (towards ads, packages and products) when placed at higher locations, whereas claim denoting “unhealthy” attributes (e.g., taste) will elicit more favorable evaluations when placed a...

  17. Managing complexity of product mix and production flow in configure-to-order production systems

    DEFF Research Database (Denmark)

    Myrodia, Anna; Bonev, Martin; Hvam, Lars

    2014-01-01

    In designing configure-to-order production systems for a growing product variety, companies are challenged with an increased complexity for obtaining high productivity levels and cost-effectiveness. In academia several optimization methods and conceptual frameworks for substituting components, or...

  18. Characterization of Plasmid DNA Location within Chitosan/PLGA/pDNA Nanoparticle Complexes Designed for Gene Delivery

    Directory of Open Access Journals (Sweden)

    Hali Bordelon

    2011-01-01

    Full Text Available Poly(D,L-lactide-co-glycolide- (PLGA-chitosan nanoparticles are becoming an increasingly common choice for the delivery of nucleic acids to cells for various genetic manipulation techniques. These particles are biocompatible, with tunable size and surface properties, possessing an overall positive charge that promotes complex formation with negatively charged nucleic acids. This study examines properties of the PLGA-chitosan nanoparticle/plasmid DNA complex after formation. Specifically, the study aims to determine the optimal ratio of plasmid DNA:nanoparticles for nucleic acid delivery purposes and to elucidate the location of the pDNA within these complexes. Such characterization will be necessary for the adoption of these formulations in a clinical setting. The ability of PLGA-chitosan nanoparticles to form complexes with pDNA was evaluated by using the fluorescent intercalating due OliGreen to label free plasmid DNA. By monitoring the fluorescence at different plasmid: nanoparticle ratios, the ideal plasmid:nanoparticle ration for complete complexation of plasmid was determined to be 1:50. Surface-Enhanced Raman Spectroscopy and gel digest studies suggested that even at these optimal complexation ratios, a portion of the plasmid DNA was located on the outer complex surface. This knowledge will facilitate future investigations into the functionality of the system in vitro and in vivo.

  19. Subsumed complexity: abiogenesis as a by-product of complex energy transduction

    Science.gov (United States)

    Adam, Z. R.; Zubarev, D.; Aono, M.; Cleaves, H. James

    2017-11-01

    The origins of life bring into stark relief the inadequacy of our current synthesis of thermodynamic, chemical, physical and information theory to predict the conditions under which complex, living states of organic matter can arise. Origins research has traditionally proceeded under an array of implicit or explicit guiding principles in lieu of a universal formalism for abiogenesis. Within the framework of a new guiding principle for prebiotic chemistry called subsumed complexity, organic compounds are viewed as by-products of energy transduction phenomena at different scales (subatomic, atomic, molecular and polymeric) that retain energy in the form of bonds that inhibit energy from reaching the ground state. There is evidence for an emergent level of complexity that is overlooked in most conceptualizations of abiogenesis that arises from populations of compounds formed from atomic energy input. We posit that different forms of energy input can exhibit different degrees of dissipation complexity within an identical chemical medium. By extension, the maximum capacity for organic chemical complexification across molecular and macromolecular scales subsumes, rather than emerges from, the underlying complexity of energy transduction processes that drive their production and modification. This article is part of the themed issue 'Reconceptualizing the origins of life'.

  20. Product Complexity Impact on Quality and Delivery Performance

    OpenAIRE

    Nielsen, Jeppe Bjerrum; Hvam, Lars

    2011-01-01

    Existing literature on product portfolio complexity is mainly focused on cost related aspects. It is widely acknowledged that an increase in a company’s product portfolio will lead to an increase in complexity related costs such as order management, procurement and inventory. The objective of this article is to examine which other factors that might be affected when a company is expanding its product portfolio, if initiatives are not taken to accommodate this increase. Empirical work carried ...

  1. Research on the EDM Technology for Micro-holes at Complex Spatial Locations

    Science.gov (United States)

    Y Liu, J.; Guo, J. M.; Sun, D. J.; Cai, Y. H.; Ding, L. T.; Jiang, H.

    2017-12-01

    For the demands on machining micro-holes at complex spatial location, several key technical problems are conquered such as micro-Electron Discharge Machining (micro-EDM) power supply system’s development, the host structure’s design and machining process technical. Through developing low-voltage power supply circuit, high-voltage circuit, micro and precision machining circuit and clearance detection system, the narrow pulse and high frequency six-axis EDM machining power supply system is developed to meet the demands on micro-hole discharging machining. With the method of combining the CAD structure design, CAE simulation analysis, modal test, ODS (Operational Deflection Shapes) test and theoretical analysis, the host construction and key axes of the machine tool are optimized to meet the position demands of the micro-holes. Through developing the special deionized water filtration system to make sure that the machining process is stable enough. To verify the machining equipment and processing technical developed in this paper through developing the micro-hole’s processing flow and test on the real machine tool. As shown in the final test results: the efficient micro-EDM machining pulse power supply system, machine tool host system, deionized filtration system and processing method developed in this paper meet the demands on machining micro-holes at complex spatial locations.

  2. Methods for forming complex oxidation reaction products including superconducting articles

    International Nuclear Information System (INIS)

    Rapp, R.A.; Urquhart, A.W.; Nagelberg, A.S.; Newkirk, M.S.

    1992-01-01

    This patent describes a method for producing a superconducting complex oxidation reaction product of two or more metals in an oxidized state. It comprises positioning at least one parent metal source comprising one of the metals adjacent to a permeable mass comprising at least one metal-containing compound capable of reaction to form the complex oxidation reaction product in step below, the metal component of the at least one metal-containing compound comprising at least a second of the two or more metals, and orienting the parent metal source and the permeable mass relative to each other so that formation of the complex oxidation reaction product will occur in a direction towards and into the permeable mass; and heating the parent metal source in the presence of an oxidant to a temperature region above its melting point to form a body of molten parent metal to permit infiltration and reaction of the molten parent metal into the permeable mass and with the oxidant and the at least one metal-containing compound to form the complex oxidation reaction product, and progressively drawing the molten parent metal source through the complex oxidation reaction product towards the oxidant and towards and into the adjacent permeable mass so that fresh complex oxidation reaction product continues to form within the permeable mass; and recovering the resulting complex oxidation reaction product

  3. Central location test vs. home use test: Contrasting results depending on product type

    NARCIS (Netherlands)

    Boutrolle, I.; Delarue, J.; Arranz, D.; Rogeaux, M.; Köster, E.P.

    2007-01-01

    Marketing professionals and sensory scientists have several hedonic testing methods at their disposal to assess product acceptability. The central location test (CLT) which usually takes place in a standardised location under controlled conditions is more frequently used than the home use test

  4. RFID Location Algorithm

    Directory of Open Access Journals (Sweden)

    Wang Zi Min

    2016-01-01

    Full Text Available With the development of social services, people’s living standards improve further requirements, there is an urgent need for a way to adapt to the complex situation of the new positioning technology. In recent years, RFID technology have a wide range of applications in all aspects of life and production, such as logistics tracking, car alarm, security and other items. The use of RFID technology to locate, it is a new direction in the eyes of the various research institutions and scholars. RFID positioning technology system stability, the error is small and low-cost advantages of its location algorithm is the focus of this study.This article analyzes the layers of RFID technology targeting methods and algorithms. First, RFID common several basic methods are introduced; Secondly, higher accuracy to political network location method; Finally, LANDMARC algorithm will be described. Through this it can be seen that advanced and efficient algorithms play an important role in increasing RFID positioning accuracy aspects.Finally, the algorithm of RFID location technology are summarized, pointing out the deficiencies in the algorithm, and put forward a follow-up study of the requirements, the vision of a better future RFID positioning technology.

  5. Stratigraphic and tectonic revision of Cerro Olivo Complex located of Southeastern of Uruguay

    International Nuclear Information System (INIS)

    Masquelin, E.

    2004-01-01

    This paper presents a stratigraphic and tectonic revision of Cerro Olivo Complex, located in the Southeastern part of the Uruguayan Predevonian Shield. This informal lithostratigraphic unit constitutes the country rock for the emplacement of late-orogenic granitoids, during Neoproterozoic to Cambrian times. This unit groups all the lithodemes affected by deformation and metamorphism. Recent studies indicate the presence of straight gneisses of quartzo-feldspathic composition in the coast of Maldonado Department. These rocks were interpreted as the result of intense deformation in high temperature. These tectonites base a new stratigraphic insight for the complex. They allow their lithotypes to be organized by petrotectonic features, being a function of PT conditions for every last strain process [es

  6. Impacts of facility size and location decisions on ethanol production cost

    International Nuclear Information System (INIS)

    Kocoloski, Matt; Michael Griffin, W.; Scott Matthews, H.

    2011-01-01

    Cellulosic ethanol has been identified as a promising alternative to fossil fuels to provide energy for the transportation sector. One of the obstacles cellulosic ethanol must overcome in order to contribute to transportation energy demand is the infrastructure required to produce and distribute the fuel. Given a nascent cellulosic ethanol industry, locating cellulosic ethanol refineries and creating the accompanying infrastructure is essentially a greenfield problem that may benefit greatly from quantitative analysis. This study models cellulosic ethanol infrastructure investment using a mixed integer program (MIP) that locates ethanol refineries and connects these refineries to the biomass supplies and ethanol demands in a way that minimizes the total cost. For the single- and multi-state regions examined in this study, larger facilities can decrease ethanol costs by $0.20-0.30 per gallon, and placing these facilities in locations that minimize feedstock and product transportation costs can decrease ethanol costs by up to $0.25 per gallon compared to uninformed placement that could result from influences such as local subsidies to encourage economic development. To best benefit society, policies should allow for incentives that encourage these low-cost production scenarios and avoid politically motivated siting of plants. - Research highlights: → Mixed-integer programming can be used to model ethanol infrastructure investment. → Large cellulosic ethanol facilities can decrease production cost by $0.20/gallon. → Optimized facility placement can save $0.25/gallon.

  7. Selection of a plant location - A case study: Urea production using ...

    African Journals Online (AJOL)

    Selection of a plant location - A case study: Urea production using Calub Gas. ... The criteria are. amongst others, supply of raw materials and fuel, market proximity, water supply. waste ... To set up · critical factors for Ethiopian scenario

  8. MODERN TOOLS OF PRODUCT PROMOTION OF MILITARY-INDUSTRIAL COMPLEX

    OpenAIRE

    Tuliakova, I. R.; Chesnokova, M.S.

    2014-01-01

    This article is devoted to the promotion of production of the military-industrial complex. In the new economy require specially coordinated effort to promote products, was no exception and the military-industrial complex. The article notes that the way can be used as tools of industrial marketing, marketing tools and experience.

  9. Modeling a four-layer location-routing problem

    Directory of Open Access Journals (Sweden)

    Mohsen Hamidi

    2012-01-01

    Full Text Available Distribution is an indispensable component of logistics and supply chain management. Location-Routing Problem (LRP is an NP-hard problem that simultaneously takes into consideration location, allocation, and vehicle routing decisions to design an optimal distribution network. Multi-layer and multi-product LRP is even more complex as it deals with the decisions at multiple layers of a distribution network where multiple products are transported within and between layers of the network. This paper focuses on modeling a complicated four-layer and multi-product LRP which has not been tackled yet. The distribution network consists of plants, central depots, regional depots, and customers. In this study, the structure, assumptions, and limitations of the distribution network are defined and the mathematical optimization programming model that can be used to obtain the optimal solution is developed. Presented by a mixed-integer programming model, the LRP considers the location problem at two layers, the allocation problem at three layers, the vehicle routing problem at three layers, and a transshipment problem. The mathematical model locates central and regional depots, allocates customers to plants, central depots, and regional depots, constructs tours from each plant or open depot to customers, and constructs transshipment paths from plants to depots and from depots to other depots. Considering realistic assumptions and limitations such as producing multiple products, limited production capacity, limited depot and vehicle capacity, and limited traveling distances enables the user to capture the real world situations.

  10. SUBSTANTIATION OF SOLUTIONS PERTAINING TO COMPLEX PRODUCTION RECONSTRUCTION

    Directory of Open Access Journals (Sweden)

    V. Y. Gurinovich

    2011-01-01

    Full Text Available While taking an example of reconstruction and modernization of OJSC «Construction and Mounting Trust No.16, Novopolotsk» the paper substantiates solutions for complex production reconstruction. The production reconstruction is divided in three start-up facilities ensuring continuous finished-product output.

  11. New complex product introduction by means of product configuration

    DEFF Research Database (Denmark)

    Bonev, Martin; Korell, Manuel; Hvam, Lars

    -uct innovation can effectively been supported. Es-pecially for engineering companies moving to-wards Mass Customization, compared to mass pro-ducers the challenges caused by the complexity of their products and by the highly uncertain markets are much higher. This study develops and validates a framework which....... Traditional research has thereby either focused on defining modelling techniques for the configuration model of stable products, on improved configura-tion algorithms, or on the impact of configurators on companies’ operations. However, little attention has yet been paid how the growing need for prod...

  12. Managing product complexity: It`s just a matter of time

    Energy Technology Data Exchange (ETDEWEB)

    Hinckley, C.M.

    1998-06-01

    It has long been the goal of designers to identify a robust measure of product complexity to guide product decisions. Using Design for Assembly evaluations from over 225 assemblies and subassemblies, alternative measures of product complexity are identified and compared. Time is shown to be the most consistently predicted, useful, and fungible measure. The distribution of assembly times for a product can be modeled by Pareto`s law. This leads to a new, more effective product design guideline and a predictive tool that enables rapid and accurate prediction of assembly times for redesigned products without having to repeat DFMA analysis.

  13. Impact of production location, production system, and variety on the volatile organic compounds fingerprints and sensory characteristics of tomatoes

    NARCIS (Netherlands)

    Muilwijk, Mirthe; Heenan, Samuel; Koot, Alex; Ruth, Van Saskia M.

    2015-01-01

    Consumers have more and more interest in where and how their foods are produced. However, it is often challenging to discriminate products from different production locations and systems. The objective of this study was to examine fingerprinting of volatile organic compounds (VOCs) as an approach

  14. The prevalence at birth of congenital malformations in the city of Ozyorsk located near the nuclear complex Mayak production association

    Energy Technology Data Exchange (ETDEWEB)

    Petrushkina, N. P.; Koshurnikova, N. A.; Okatenko, P. V.

    2004-07-01

    For many years possible genetic effects of exposure to ionizing radiation have been a subject of interest and concern, but data from studies of the risk of radiation-induced hereditary effects in humans are limited. the most extensive human studies of genetic effects were those conducted on the Japanese. A-bomb survivors. In These studies in investigators examined the association of various levels of radiation exposure and several different endpoints, including major congenital defects, stillbirth, death during the first week of life, survivals, and sex ratio and Down's syndrome (8, (14-16). Although associations of these outcomes with radiation exposure were in the positive direction, none were close to statistical significance. Only teratogenic effects of in utero exposure at Hiroshima and Nagasaki, microcephaly and mental retardation, have been observed (8, (10, 16)). Of most interest is possible association of congenital malformations (CMs) with parental occupational radiation exposure. Determination of the role of parental occupational exposure in induction of CMs in children is necessary to evaluate reliability of radiation protection standards Epidemiological studies conducted on the basis of Registries of children who were born in regions located near a nuclear complex may be useful for such evaluation. It is preferable to carry out such studies on the basis of population registries, since long follow-up in large populations allows to reveal increased frequency of even very rare forms of congenital abnormalities. In a case-control study of association of parental occupational exposure due to Hanford Nuclear Site and risk of CMs in their offspring there was no evidence of such an association (12, 13). Our investigation is conducted on the basis of the basis of the Registry of children of Ozyorsk. The whole Registry includes all children with 1948-1988 birth years show were born or-came to town at the age of 0-14 years, and were residents of these towns

  15. The prevalence at birth of congenital malformations in the city of Ozyorsk located near the nuclear complex Mayak production association

    International Nuclear Information System (INIS)

    Petrushkina, N. P.; Koshurnikova, N. A.; Okatenko, P. V.

    2004-01-01

    For many years possible genetic effects of exposure to ionizing radiation have been a subject of interest and concern, but data from studies of the risk of radiation-induced hereditary effects in humans are limited. the most extensive human studies of genetic effects were those conducted on the Japanese. A-bomb survivors. In These studies in investigators examined the association of various levels of radiation exposure and several different endpoints, including major congenital defects, stillbirth, death during the first week of life, survivals, and sex ratio and Down's syndrome (8, (14-16). Although associations of these outcomes with radiation exposure were in the positive direction, none were close to statistical significance. Only teratogenic effects of in utero exposure at Hiroshima and Nagasaki, microcephaly and mental retardation, have been observed (8, (10, 16)). Of most interest is possible association of congenital malformations (CMs) with parental occupational radiation exposure. Determination of the role of parental occupational exposure in induction of CMs in children is necessary to evaluate reliability of radiation protection standards Epidemiological studies conducted on the basis of Registries of children who were born in regions located near a nuclear complex may be useful for such evaluation. It is preferable to carry out such studies on the basis of population registries, since long follow-up in large populations allows to reveal increased frequency of even very rare forms of congenital abnormalities. In a case-control study of association of parental occupational exposure due to Hanford Nuclear Site and risk of CMs in their offspring there was no evidence of such an association (12, 13). Our investigation is conducted on the basis of the basis of the Registry of children of Ozyorsk. The whole Registry includes all children with 1948-1988 birth years show were born or-came to town at the age of 0-14 years, and were residents of these towns one

  16. Calculation of Complexity Costs – An Approach for Rationalizing a Product Program

    DEFF Research Database (Denmark)

    Hansen, Christian Lindschou; Mortensen, Niels Henrik; Hvam, Lars

    2012-01-01

    This paper proposes an operational method for rationalizing a product program based on the calculation of complexity costs. The method takes its starting point in the calculation of complexity costs on a product program level. This is done throughout the value chain ranging from component invento...... of a product program. These findings represent an improved decision basis for the planning of reactive and proactive initiatives of rationalizing a product program.......This paper proposes an operational method for rationalizing a product program based on the calculation of complexity costs. The method takes its starting point in the calculation of complexity costs on a product program level. This is done throughout the value chain ranging from component...... inventories at the factory sites, all the way to the distribution of finished goods from distribution centers to the customers. The method proposes a step-wise approach including the analysis, quantification and allocation of product program complexity costs by the means of identifying of a number...

  17. Buildings 104 and 142 Complex Physical Protection and Material Control and Accounting Upgrades at the Mayak Production Association

    International Nuclear Information System (INIS)

    Aichele, Walter T.; Dwyer, Gregory M.; Larsen, R.; Malone, Tim

    2004-01-01

    The Federal State Unitary Enterprise Mayak Production Association (Mayak) and the U.S. Material Protection, Control and Accounting (MPC and A) United States Project Team (USPT) have worked together for a number of years as part of the U.S. national Nuclear Security Administration's (NNSA) MPC and A program to implement both Physical Protection (PP) and Material Control and Accounting (MC and A) upgrades within the Buildings 104 and 142 Complex, a long-term storage area for uranium and plutonium oxide located within Mayak's RT-1 Spent Fuel Reprocessing Plant. This paper focuses on the successes and areas for improvement in the analysis, planning, construction, implementation, and completion of a complex and labor-intensive project aimed at the refurbishment of two existing, in service, long-term special nuclear material (SNM) storage buildings within a Russian SNM production facility

  18. Productivity? Domain Complexity vs. Tacit Knowledge

    DEFF Research Database (Denmark)

    Madsen, Erik Skov; Mikkelsen, Lars Lindegaard

    This paper discusses productivity in relation to tacit knowledge (which in the paper is regarded as skills, experiences, competences and attitudes) and domain complexity. The study is based on five very different case studies; three studies are conducted in Den¬mark, China, and the Czech Republic...

  19. 18 CFR 292.208 - Special requirements for hydroelectric small power production facilities located at a new dam or...

    Science.gov (United States)

    2010-04-01

    ... for hydroelectric small power production facilities located at a new dam or diversion. 292.208 Section... requirements for hydroelectric small power production facilities located at a new dam or diversion. (a) A hydroelectric small power production facility that impounds or diverts the water of a natural watercourse by...

  20. Product Complexity Impact on Quality and Delivery Performance

    DEFF Research Database (Denmark)

    Nielsen, Jeppe Bjerrum; Hvam, Lars

    2011-01-01

    Existing literature on product portfolio complexity is mainly focused on cost related aspects. It is widely acknowledged that an increase in a company’s product portfolio will lead to an increase in complexity related costs such as order management, procurement and inventory. The objective...... is increased, but it is not the only factor affected. We can document that there is a tendency towards increasing lead times as well as a drop in on time delivery and quality for newly introduced product variants. This means that the company experiences a reduced ability to deliver on time while also receiving...... of this article is to examine which other factors that might be affected when a company is expanding its product portfolio, if initiatives are not taken to accommodate this increase. Empirical work carried out in a large international engineering company having a market leader position confirms that cost...

  1. 18 CFR 292.209 - Exceptions from requirements for hydroelectric small power production facilities located at a new...

    Science.gov (United States)

    2010-04-01

    ... requirements for hydroelectric small power production facilities located at a new dam or diversion. 292.209... Exceptions from requirements for hydroelectric small power production facilities located at a new dam or... the Federal Power Act, at which non-Federal hydroelectric development is permissible; or (2) An...

  2. Reconfiguring The Supply Chain For Complex Engineered Products

    DEFF Research Database (Denmark)

    Wæhrens, Brian Vejrum; Asmussen, Jesper Normann

    2016-01-01

    of the SC, the product and market requirements. This paper seeks to investigate the factors which create a need for supply chain reconfiguration in the context of the Complex Product Systems, together with the enablers and barriers for successfully realizing supply chain improvements through reconfiguration....

  3. Seasonality in birth defects, agricultural production and urban location.

    Science.gov (United States)

    McKinnish, Terra; Rees, Daniel I; Langlois, Peter H

    2014-12-01

    This paper tests whether the strength of the "spring spike" in birth defects is related to agricultural production and urban location using Texas Birth Defects Registry data for the period 1996-2007. We find evidence of a spike in birth defects among children conceived in the spring and summer, but it is more pronounced in urban non-agricultural counties than in other types of counties. Furthermore, the spike lasts longer in urban non-agricultural counties as compared to other types of counties. Copyright © 2014 Elsevier B.V. All rights reserved.

  4. Complex products and Systems: Potential from using layout platforms

    NARCIS (Netherlands)

    Hofer, A.P.; Halman, J.I.M.

    2004-01-01

    In their quest to manage the complexity of offering greater product variety, firms in many industries are considering platform-based development of product families. Key in this approach is the sharing of components, modules, and other assets across a family of products. Current research indicates

  5. Low complexity algorithms to independently and jointly estimate the location and range of targets using FMCW

    KAUST Repository

    Ahmed, Sajid

    2017-05-12

    The estimation of angular-location and range of a target is a joint optimization problem. In this work, to estimate these parameters, by meticulously evaluating the phase of the received samples, low complexity sequential and joint estimation algorithms are proposed. We use a single-input and multiple-output (SIMO) system and transmit frequency-modulated continuous-wave signal. In the proposed algorithm, it is shown that by ignoring very small value terms in the phase of the received samples, fast-Fourier-transform (FFT) and two-dimensional FFT can be exploited to estimate these parameters. Sequential estimation algorithm uses FFT and requires only one received snapshot to estimate the angular-location. Joint estimation algorithm uses two-dimensional FFT to estimate the angular-location and range of the target. Simulation results show that joint estimation algorithm yields better mean-squared-error (MSE) for the estimation of angular-location and much lower run-time compared to conventional MUltiple SIgnal Classification (MUSIC) algorithm.

  6. Low complexity algorithms to independently and jointly estimate the location and range of targets using FMCW

    KAUST Repository

    Ahmed, Sajid; Jardak, Seifallah; Alouini, Mohamed-Slim

    2017-01-01

    The estimation of angular-location and range of a target is a joint optimization problem. In this work, to estimate these parameters, by meticulously evaluating the phase of the received samples, low complexity sequential and joint estimation algorithms are proposed. We use a single-input and multiple-output (SIMO) system and transmit frequency-modulated continuous-wave signal. In the proposed algorithm, it is shown that by ignoring very small value terms in the phase of the received samples, fast-Fourier-transform (FFT) and two-dimensional FFT can be exploited to estimate these parameters. Sequential estimation algorithm uses FFT and requires only one received snapshot to estimate the angular-location. Joint estimation algorithm uses two-dimensional FFT to estimate the angular-location and range of the target. Simulation results show that joint estimation algorithm yields better mean-squared-error (MSE) for the estimation of angular-location and much lower run-time compared to conventional MUltiple SIgnal Classification (MUSIC) algorithm.

  7. Low complexity joint estimation of reflection coefficient, spatial location, and Doppler shift for MIMO-radar by exploiting 2D-FFT

    KAUST Repository

    Jardak, Seifallah

    2014-10-01

    In multiple-input multiple-output (MIMO) radar, to estimate the reflection coefficient, spatial location, and Doppler shift of a target, maximum-likelihood (ML) estimation yields the best performance. For this problem, the ML estimation requires the joint estimation of spatial location and Doppler shift, which is a two dimensional search problem. Therefore, the computational complexity of ML estimation is prohibitively high. In this work, to estimate the parameters of a target, a reduced complexity optimum performance algorithm is proposed, which allow two dimensional fast Fourier transform to jointly estimate the spatial location and Doppler shift. To asses the performances of the proposed estimators, the Cramér-Rao-lower-bound (CRLB) is derived. Simulation results show that the mean square estimation error of the proposed estimators achieve the CRLB. © 2014 IEEE.

  8. The virtual product-process design laboratory to manage the complexity in the verification of formulated products

    DEFF Research Database (Denmark)

    Conte, Elisa; Gani, Rafiqul; Malik, Tahir I.

    2011-01-01

    -Process Design laboratory (virtual PPD-lab) software is based on this decomposition strategy for the design of formulated liquid products. When the needed models are available in the software, the solution of formulation design/verification problems is straightforward, while when models are not available...... mixtures need to be predicted. This complexity has to be managed through decomposition of the problem into sub-problems. Each sub-problem is solved and analyzed and, from the knowledge gained, an overall evaluation of the complex chemical system representing the product is made. The virtual Product...... in the software library, they need to be developed and/or implemented. The potential of the virtual PPD-lab in managing the complexity in the verification of formulated products, after the needed models have been developed and implemented, is highlighted in this paper through a case study from industry dealing...

  9. Analysis of Product Complexity considering Disruption Cost in Fast Fashion Supply Chain

    Directory of Open Access Journals (Sweden)

    Shaheen Sardar

    2015-01-01

    Full Text Available Outsourcing in the textile industry has been playing an important role in the global economy for six decades. Recently, reshoring is an emerging trend due to various complexities involved in supply chain management. As compared with basic textile and apparel products, fast fashion products are complex in their own way. A single assortment contains several new styles, colors, and sizes with unpredictable demand and urgent deadlines. Numerous assortments run simultaneously in the supply chain. For each assortment, the garment manufacturer has to source various types of fabrics and materials from different suppliers and then manufacture the garments to ship within the deadlines. This complexity contributes to supply chain disruption. This paper develops a model to estimate supply chain disruption cost as a function of fast fashion product complexity in the global outsourcing environment. Estimation of disruption cost will help us to increase visibility and eliminate the bottlenecks in supply chain. Model conclusions are used to develop a method to manage the level of product complexity from the global supply chain perspective. Several strategies are proposed to manage the impact of product complexity on supply chain design.

  10. 2003 assessment of PCDDs-PCDFs emissions from the Copesul/South Petrochemical complex located in southern Brazil

    Energy Technology Data Exchange (ETDEWEB)

    Deschamps, M.; Allard, J.L. [SNC-Lavalin Environment Inc., Montreal, PQ (Canada); Rangel, C.M.P.; Ribeiro, C.; Dos Santos, S.T.F. [Companhia Petroquimica do Sul, Triunfo (Brazil)

    2004-09-15

    COPESUL is the Raw Material and Utilities Central of the South Petrochemical Complex, this, being the most modern industrial facility of its type in Brazil, and the second largest naphtha cracker in the country. Responsible for more than 40% of Brazilian olefins production, it is also among the largest crackers (on the same site) in the world. The majority of COPESUL products are transformed by downstream industries of the Complex into thermoplastics resins, synthetic rubber, styrene and solvents that are widely used in the manufacturing of packing material (food, hygiene, cleaning), electronic appliances, medical and surgical supplies, toys and in the car industries, to be consumed in Brazil and foreign countries. At the request of the state of Rio Grande do Sul Environmental Protection Agency (Fundacao Estadual de Protecao Ambiental or FEPAM), an Environmental Assessment of Priority Pollutants (EAPP) was performed by Copesul at the end of the year 2003. EAPPs have been voluntarily performed at the Petrochemical Complex since 1986 on a basis of once every three year. It is now performed as a requirement which is part of the petrochemical plant operational license. Among the different (organic and inorganic) parameters tested, PCDDs-PCDFs remained a main concern to the local State Agency with regards to the Complex activities and of it's potential impact on the human health and the environment, despite the fact that the Complex does not use nor produce any organochlorinated product.

  11. Efficiency mark of the two-product power complex of nuclear power plant

    Science.gov (United States)

    Khrustalev, V. A.; Suchkov, V. M.

    2017-11-01

    The article discusses the combining nuclear power plants (NPP) with pressurized water reactors and distillation-desalination plants (DDP), their joint mode of operation during periods of coating failures of the electric power load graphs and thermo-economical efficiency. Along with the release of heat and generation of electric energy a desalination complex with the nuclear power plant produces distillate. Part of the selected steam “irretrievably lost” with a mix of condensation of this vapor in a desalination machine with a flow of water for distillation. It means that this steam transforms into condition of acquired product - distillate. The article presents technical solutions for the return of the working fluid for turbine К-1000-60/1500-2 и К-1200-6,8/50, as well as permissible part of low pressure regime according to the number of desalination units for each turbine. Patent for the proposed two-product energy complex, obtained by Gagarin State Technical University is analyzed. The energy complex has such system advantages as increasing the capacity factor of a nuclear reactor and also allows to solve the problem of shortage of fresh water. Thermo-economics effectiveness of this complex is determined by introducing a factor-“thermo-economic index”. During analyzing of the results of the calculations of a thermo-economic index we can see a strong influence of the cost factor of the distillate on the market. Then higher participation of the desalination plant in coverage of the failures of the graphs of the electric loading then smaller the payback period of the NPP. It is manifested more clearly, as it’s shown in the article, when pricing options depend on time of day and the configuration of the daily electric load diagram. In the geographical locations of the NPPs with PWR the Russian performance in a number of regions with low freshwater resources and weak internal electrical connections combined with DDP might be one of the ways to improve the

  12. A multi-step method with signal quality assessment and fine-tuning procedure to locate maternal and fetal QRS complexes from abdominal ECG recordings

    International Nuclear Information System (INIS)

    Liu, Chengyu; Li, Peng; Zhao, Lina; Di Maria, Costanzo; Zhang, Henggui; Chen, Zhiqing

    2014-01-01

    Non-invasive monitoring of fetal electrocardiogram (fECG) plays an important role in detecting and diagnosing fetal diseases. This study aimed to develop a multi-step method for locating both maternal and fetal QRS complexes from abdominal ECG (aECG) recordings. The proposed method included four major steps: abdominal ECG pre-processing, maternal QRS complex locating, maternal ECG cancellation and fetal QRS complex locating. Signal quality assessment (SQA) and fine-tuning for maternal ECG (FTM) were implemented in the first and third steps, respectively. The method was then evaluated using 75 non-invasive 4-channel aECG recordings provided by the PhysioNet/Computing in Cardiology Challenge 2013. The F 1 measure, which is a new index introduced by Behar et al (2013 Proc. Comput. Cardiol. 40 297–300), was used to assess the locating accuracy. The other two indices, mean squared error of heart rate (MSE H R) between the fetal HR signals estimated from the reference and our method (MSE H R in bpm 2 ) and root mean squared difference between the corresponding fetal RR intervals (MSE R R in ms) were also used to assess the locating accuracy. Overall, for the maternal QRS complex, the F 1 measure was 98.4% from the method without the implementation of SQA, and it was improved to 99.8% with SQA. For the fetal QRS complex, the F 1 measure, MSE H R and MSE R R were 84.9%, 185.6 bpm 2 and 19.4 ms for the method without both SQA and FTM procedures. They were improved to 93.9%, 47.5 bpm 2 and 7.6 ms with both SQA and FTM procedures. These improvements were observed from each individual subject. It can be concluded that implementing both SQA and FTM procedures could achieve better performance for locating both maternal and fetal QRS complexes. (paper)

  13. Book reviews: Miroslav N. Jovanovic – Evolutionary Economic Geography. Location of Production in the European Union

    Directory of Open Access Journals (Sweden)

    Raluca G. Popescu

    2011-12-01

    Full Text Available The book tries to answer the problem of locating production of a company in the geographic space analyzing what determines productivity differences between regions using the theory of evolutionary economic geography. Evolutionary economics studies “the origin, change, direction and speed in the spatial distribution and organization of as well as production and consumption in a certain period of time.” The studied problem is relevant in order to know not only what will be the future location of jobs, their quality and quantity but also where will take place the maximization of profits, the collection of taxes, the public spending, etc.

  14. Platform strategy for complex products and systems

    NARCIS (Netherlands)

    Alblas, A.A.

    2011-01-01

    The thesis of Alex Alblas presents a design reuse strategy for firms producing complex products and systems (CoPS). Examples of CoPS include industrial machinery, oil-rigs, electrical power distribution systems, integrated mail processing systems and printing press machinery. CoPS firms are

  15. Reduction of product platform complexity by vectorial Euclidean algorithm

    International Nuclear Information System (INIS)

    Navarrete, Israel Aguilera; Guzman, Alejandro A. Lozano

    2013-01-01

    In traditional machine, equipment and devices design, technical solutions are practically independent, thus increasing designs cost and complexity. Overcoming this situation has been tackled just using designer's experience. In this work, a product platform complexity reduction is presented based on a matrix representation of technical solutions versus product properties. This matrix represents the product platform. From this matrix, the Euclidean distances among technical solutions are obtained. Thus, the vectorial distances among technical solutions are identified in a new matrix of order of the number of technical solutions identified. This new matrix can be reorganized in groups with a hierarchical structure, in such a way that modular design of products is now more tractable. As a result of this procedure, the minimum vector distances are found thus being possible to identify the best technical solutions for the design problem raised. Application of these concepts is shown with two examples.

  16. Mechanism of management of competitiveness of production of agrarian and industrial complex

    Directory of Open Access Journals (Sweden)

    Buryak E. A.

    2016-04-01

    Full Text Available the concept of competitiveness and mechanisms of management of competitiveness of production is considered. Major factors of ensuring competitiveness of production of agrarian and industrial complex are allocated. The main problems of production of wheat in the Republic of Crimea making negative impact on the level of her competitiveness are revealed. The mechanism of management of competitiveness of production of agrarian and industrial complex is developed.

  17. Equivalence of complex drug products: advances in and challenges for current regulatory frameworks.

    Science.gov (United States)

    Hussaarts, Leonie; Mühlebach, Stefan; Shah, Vinod P; McNeil, Scott; Borchard, Gerrit; Flühmann, Beat; Weinstein, Vera; Neervannan, Sesha; Griffiths, Elwyn; Jiang, Wenlei; Wolff-Holz, Elena; Crommelin, Daan J A; de Vlieger, Jon S B

    2017-11-01

    Biotechnology and nanotechnology provide a growing number of innovator-driven complex drug products and their copy versions. Biologics exemplify one category of complex drugs, but there are also nonbiological complex drug products, including many nanomedicines, such as iron-carbohydrate complexes, drug-carrying liposomes or emulsions, and glatiramoids. In this white paper, which stems from a 1-day conference at the New York Academy of Sciences, we discuss regulatory frameworks in use worldwide (e.g., the U.S. Food and Drug Administration, the European Medicines Agency, the World Health Organization) to approve these complex drug products and their follow-on versions. One of the key questions remains how to assess equivalence of these complex products. We identify a number of points for which consensus was found among the stakeholders who were present: scientists from innovator and generic/follow-on companies, academia, and regulatory bodies from different parts of the world. A number of topics requiring follow-up were identified: (1) assessment of critical attributes to establish equivalence for follow-on versions, (2) the need to publish scientific findings in the public domain to further progress in the field, (3) the necessity to develop worldwide consensus regarding nomenclature and labeling of these complex products, and (4) regulatory actions when substandard complex drug products are identified. © 2017 The Authors. Annals of the New York Academy of Sciences published by Wiley Periodicals, Inc. on behalf of New York Academy of Sciences.

  18. Complex products and systems: potential from using lay out platforms

    NARCIS (Netherlands)

    Halman, Johannes I.M.; Hofer, Adrian P.

    2004-01-01

    In their quest to manage the complexity of offering greater product variety, firms in many industries are considering platform-based development of product families. Key in this approach is the sharing of components, modules, and other assets across a family of products. Current research indicates

  19. Environmental characterization of two potential locations at Hanford for a new production reactor

    Energy Technology Data Exchange (ETDEWEB)

    Watson, E.C.; Becker, C.D.; Fitzner, R.E.; Gano, K.A.; Imhoff, K.L.; McCallum, R.F.; Myers, D.A.; Page, T.L.; Price, K.R.; Ramsdell, J.V.; Rice D.G.; Schreiber D.L.; Skumatz L.A.; Sommer D.J.; Tawil J.J.; Wallace R.W.; Watson D.G.

    1984-09-01

    This report describes various environmental aspects of two areas on the Hanford Site that are potential locations for a New Production Reactor (NPR). The area known as the Skagit Hanford Site is considered the primary or reference site. The second area, termed the Firehouse Site, is considered the alternate site. The report encompasses an environmental characterization of these two potential NPR locations. Eight subject areas are covered: geography and demography; ecology; meteorology; hydrology; geology; cultural resources assessment; economic and social effects of station construction and operation; and environmental monitoring. 80 refs., 68 figs., 109 tabs.

  20. Complexity of Products of Some Complete and Complete Bipartite Graphs

    Directory of Open Access Journals (Sweden)

    S. N. Daoud

    2013-01-01

    Full Text Available The number of spanning trees in graphs (networks is an important invariant; it is also an important measure of reliability of a network. In this paper, we derive simple formulas of the complexity, number of spanning trees, of products of some complete and complete bipartite graphs such as cartesian product, normal product, composition product, tensor product, and symmetric product, using linear algebra and matrix analysis techniques.

  1. Portrait Of Portugal’s Nut Iii Regions In Productive Location Clusters

    Directory of Open Access Journals (Sweden)

    Francisco José Lopes de souse Diniz

    2015-03-01

    Full Text Available The purpose of this article is to piece together a picture of Portuguese regions at the end of the first decade of the twenty-first century. In particular, the authors tried to group NUT III regions according to the location of productive activities bearing in mind employment and other economic and social indicators, namely productivity and purchasing power, as well as competitiveness and environmental quality indicators. Using clusters, it was possible to obtain a map of Portugal containing 6 cluster typologies. Clearly, at one end of these typologies are the regions where tertiary activities are predominant and where there is more purchasing power, productivity and competitiveness, causing, however, more damages to the environment, whereas at the other end are the rural less competitive regions with a lower purchasing power but environmentally more attractive. In between, there are other situations which are also looked into.

  2. The Possibility Using the Power Production Function of Complex Variable for Economic Forecasting

    Directory of Open Access Journals (Sweden)

    Sergey Gennadyevich Svetunkov

    2016-09-01

    Full Text Available The possibility of dynamic analysis and forecasting production results using the power production functions of complex variables with real coefficients is considered. This model expands the arsenal of instrumental methods and allows multivariate production forecasts which are unattainable by other methods of real variables as the functions of complex variables simulate the production differently in comparison with the models of real variables. The values of coefficients of the power production functions of complex variables can be calculated for each statistical observation. This allows to consider the change of the coefficients over time, to analyze this trend and predict the values of the coefficients for a given term, thereby to predict the form of the production function, which forecasts the operating results. Thus, the model of the production function with variable coefficients is introduced into the scientific circulation. With this model, the inverse problem of forecasting might be solved, such as the determination of the necessary quantities of labor and capital to achieve the desired operational results. The study is based on the principles of the modern methodology of complex-valued economy, one of its sections is the complex-valued patterns of production functions. In the article, the possibility of economic forecasting is tested on the example of the UK economy. The results of this prediction are compared with the forecasts obtained by other methods, which have led to the conclusion about the effectiveness of the proposed approach and the method of forecasting at the macro levels of production systems. A complex-valued power model of the production function is recommended for the multivariate prediction of sustainable production systems — the global economy, the economies of individual countries, major industries and regions.

  3. Stem Complexity and Inflectional Encoding in Language Production

    NARCIS (Netherlands)

    Janssen, D.P.; Roelofs, A.P.A.; Levelt, W.J.M.

    2004-01-01

    Three experiments are reported that examined whether stem complexity plays a role in inflecting polymorphemic words in language production. Experiment 1 showed that preparation effects for words with polymorphemic stems are larger when they are produced among words with constant inflectional

  4. Pigmented Paraaxillary Located "Complex" Basal Cell Carcinoma Imitating clinically irritated Melanocytic Lesion - Succesfull Surgical Approach in Bulgarian Patient

    Directory of Open Access Journals (Sweden)

    Cristiana Voicu

    2017-07-01

    CONCLUSION: Uncommon locations of BCCs in sun-protected areas such as the axillary region require a higher degree of suspicion for diagnosis. The complex histology of the presented case, including subtypes with differing biologic attributes, emphasises the importance of histopathological examination in the diagnosis and therapeutic management of BCC.

  5. Systems Engineering Metrics: Organizational Complexity and Product Quality Modeling

    Science.gov (United States)

    Mog, Robert A.

    1997-01-01

    Innovative organizational complexity and product quality models applicable to performance metrics for NASA-MSFC's Systems Analysis and Integration Laboratory (SAIL) missions and objectives are presented. An intensive research effort focuses on the synergistic combination of stochastic process modeling, nodal and spatial decomposition techniques, organizational and computational complexity, systems science and metrics, chaos, and proprietary statistical tools for accelerated risk assessment. This is followed by the development of a preliminary model, which is uniquely applicable and robust for quantitative purposes. Exercise of the preliminary model using a generic system hierarchy and the AXAF-I architectural hierarchy is provided. The Kendall test for positive dependence provides an initial verification and validation of the model. Finally, the research and development of the innovation is revisited, prior to peer review. This research and development effort results in near-term, measurable SAIL organizational and product quality methodologies, enhanced organizational risk assessment and evolutionary modeling results, and 91 improved statistical quantification of SAIL productivity interests.

  6. Urban tourist complexes as Multi-product companies: Market segmentation and product differentiation in Amsterdam

    OpenAIRE

    Romao, J.; Neuts, B.; Nijkamp, P.; Leeuwen, E.S. van

    2012-01-01

    The tourism sector is evolving into an advanced industrial sector. Modern tourism presupposes an attractive portfolio of tourist services for a varied set of visitors. Meanwhile, tourism destinations have turned into multifaceted tourist complexes comprising a broad package of amenities that satisfy the needs of a heterogeneous group of clients. Such tourist complexes may be regarded as export-oriented multi-product companies, characterized by spatial and functional market segmentation and by...

  7. Theory of inner product vector and its application to multi-location damage detection

    International Nuclear Information System (INIS)

    Wang Le; Yang Zhichun; Zhang Muyu; Waters, T P

    2011-01-01

    Structural damage detection methods using time domain vibration responses have shown appeal in recent years. In previous papers by the authors, the inner product vector (IPV) was proposed as a damage detection algorithm which uses cross correlation functions between vibration responses under white noise excitation or band pass white noise excitation. The proposed algorithm was verified by some simulative and experimental examples featuring a single damage location. However, damage at multiple locations was not considered. Therefore, this paper extends the application of IPV-based structural damage detection to the problem of multiple damage locations. Firstly, the theory of the IPV and its implementation in a damage detection context is reviewed. Then, two strategies for detecting multiple damages utilizing IPV are proposed. Finally, a damage detection experiment of a honeycomb sandwich composite beam is adopted to illustrate the feasibility and effectiveness of the IPV-based damage detection method.

  8. Product configuration system and its impact on product’s life cycle complexity

    DEFF Research Database (Denmark)

    Myrodia, Anna; Kristjansdottir, Katrin; Shafiee, Sara

    2016-01-01

    The purpose of this paper is to identify areas throughout a product's lifecycle processes where complexity can be reduced by implementing a product configuration system (PCS). As discussed in the literature, several benefits are realized by using a PCS in terms of product and process standardizat...... for the company in several life cycle processes....... standardization. This also leads to control and reduce of complexity both in products and processes. To this end, this research attempts to quantify and assess these benefits and is supported by empirical evidence. A case study of an engineering company is used and the results indicate significant improvements...

  9. Capturing Complex Multidimensional Data in Location-Based Data Warehouses

    DEFF Research Database (Denmark)

    Timko, Igor; Pedersen, Torben Bach

    2004-01-01

    Motivated by the increasing need to handle complex multidimensional data inlocation-based data warehouses, this paper proposes apowerful data model that is able to capture the complexities of such data. The model provides a foundation for handling complex transportationinfrastructures...

  10. WORK ALLOCATION IN COMPLEX PRODUCTION PROCESSES: A METHODOLOGY FOR DECISION SUPPORT

    OpenAIRE

    de Mello, Adriana Marotti; School of Economics, Business and Accounting at the University of São Paulo; Marx, Roberto; Polytechnic School, University of São Paulo; Zilbovicius, Mauro; Polytechnic School – University of São Paulo

    2013-01-01

    This article presents the development of a Methodology of Decision Support for Work Allocation in complex production processes. It is known that this decision is frequently taken empirically and that the methodologies available to support it are few and restricted in terms of its conceptual basis. The study of Times and Motion is one of these methodologies, but its applicability is restricted in cases of more complex production processes. The method presented here was developed as a result of...

  11. Serovar 4b complex predominates among Listeria monocytogenes isolates from imported aquatic products in China.

    Science.gov (United States)

    Chen, Jianshun; Chen, Qiaomiao; Jiang, Jianjun; Hu, Hongxia; Ye, Jiangbo; Fang, Weihuan

    2010-01-01

    Listeria monocytogenes, the causative organism of listeriosis, is primarily transmitted to humans through contaminated food. In this study, we examined 1275 batches of aquatic products imported from 29 countries and found that 36 batches from 8 countries were contaminated by Listeria (2.8%), with L. monocytogenes accounting for 2.6% (33/1275) and L. innocua for 0.2% (3/1275). Of the 23 selected L. monocytogenes isolates (from the 33 identified), 15 (65.2%) were of serovar 4b complex (4b, 4d, or 4e), three (13.0%) of 1/2a or 3a, four (17.4%) of 1/2b or 3b, and one (4.4%) of 1/2c or 3c. Notably, four of the 23 isolates belonged to epidemic clone I (ECI) and another four were associated with epidemic clone II (ECII), two highly clonal 4b clusters responsible for most of the documented listeriosis outbreaks. In the multilocus sequence typing scheme based on the concatenated genes gyrB-dapE-hisJ-sigB-ribC-purM-betL-gap-tuf, serovar 4b complex isolates from imported aquatic products exhibited significant genetic diversity. While the four ECI isolates were genetically related to those from Chinese diseased animals, both lacking one proline-rich repeat of ActA, the four ECII isolates were located between 1/2b or 3b strains. As the L. monocytogenes isolates from imported aquatic products possessed a nearly complete set of major infection-related genes, they demonstrated virulence potential in mouse model.

  12. Design features of isotope production facility at Inshas cyclotron complex. Vol. 1

    Energy Technology Data Exchange (ETDEWEB)

    Comsan, M N [Nuclear Research Center, Atomic Energy Aurhority, Cairo, (Egypt)

    1996-03-01

    The nuclear research center, AEA, Egypt is erecting at its Inshas campus cyclotron complex for multidisciplinary use for research and application. The complex is to utilize a russian made AVF cyclotron accelerator of the type MGC-20 with MeV protons. Among its applications, the accelerator will be used for the production of short lived cyclotron isotopes. This article presents a concise description of the design features of isotope production facility to be annexed to the complex layout, schemes for radio waste, ventilation, and air conditioning systems. 2 figs., 2 tabs.

  13. Efficiency increase of complex production and transport systems management

    Directory of Open Access Journals (Sweden)

    Kornilov S.

    2017-01-01

    Full Text Available This article deals with the problem of the reduced efficiency of management in complex production - transport systems due to the lack of co-ordination in the operation of industrial enterprises and transport carrying out their maintenance. The existing transport service schedules for auxiliary departments do not take into account possible changes in operating conditions, the probability of malfunctions and the amount of reserves, which leads to an increase in general production costs. To solve this problem, we propose to use the interval regulation of production and transport processes in all departments of the complex production and transport systems. Also, such regulation involves the determination of traffic service priority. This will allow passing on from the regulated control of production and transport processes to the situational one, adapted to specific conditions, and reducing losses from untimely transport servicing, which will lead to a stores reduction and efficiency increase of the enterprise circulating facilities use. Testing the effectiveness of interval regulation was performed on the system and dynamics simulation model of liquid iron transportation in the oxygen converter shop of the metallurgical enterprise. It was established that the use of interval regulation processes in iron production and its transportation will allow decreasing non-productive downtime by 21% and the amount of the liquid iron in anticipation of recasting in the oxygen converter shop – by 33%. Economical effect of reducing the liquid iron downtime during transportation to the oxygen converter shop will be about 30 million rubles per year.

  14. Feasibility study for co-locating and integrating ethanol production plants from corn starch and lignocellulosic feedstocks

    Energy Technology Data Exchange (ETDEWEB)

    Wallace, Robert [National Renewable Energy Lab. (NREL), Golden, CO (United States); Ibsen, Kelly [National Renewable Energy Lab. (NREL), Golden, CO (United States); McAloon, Andrew [U.S. Department of Agriculture, Washington, D.C. (United States); Yee, Winnie [U.S. Department of Agriculture, Washington, D.C. (United States)

    2005-01-01

    Analysis of the feasibility of co-locating corn-grain-to-ethanol and lignocellulosic ethanol plants and potential savings from combining utilities, ethanol purification, product processing, and fermentation.

  15. Appraising manufacturing location

    NARCIS (Netherlands)

    Steenhuis, H.J.; de Bruijn, E.J.

    2002-01-01

    International location of manufacturing activities is an issue for managers of manufacturing companies as well as public policy makers. For managers, the issue is relevant because international locations offer opportunities for lowering costs due to productivity improvements. For governments the

  16. Neural Correlates in the Processing of Phoneme-Level Complexity in Vowel Production

    Science.gov (United States)

    Park, Haeil; Iverson, Gregory K.; Park, Hae-Jeong

    2011-01-01

    We investigated how articulatory complexity at the phoneme level is manifested neurobiologically in an overt production task. fMRI images were acquired from young Korean-speaking adults as they pronounced bisyllabic pseudowords in which we manipulated phonological complexity defined in terms of vowel duration and instability (viz., COMPLEX:…

  17. A foundational methodology for determining system static complexity using notional lunar oxygen production processes

    Science.gov (United States)

    Long, Nicholas James

    This thesis serves to develop a preliminary foundational methodology for evaluating the static complexity of future lunar oxygen production systems when extensive information is not yet available about the various systems under consideration. Evaluating static complexity, as part of a overall system complexity analysis, is an important consideration in ultimately selecting a process to be used in a lunar base. When system complexity is higher, there is generally an overall increase in risk which could impact the safety of astronauts and the economic performance of the mission. To evaluate static complexity in lunar oxygen production, static complexity is simplified and defined into its essential components. First, three essential dimensions of static complexity are investigated, including interconnective complexity, strength of connections, and complexity in variety. Then a set of methods is developed upon which to separately evaluate each dimension. Q-connectivity analysis is proposed as a means to evaluate interconnective complexity and strength of connections. The law of requisite variety originating from cybernetic theory is suggested to interpret complexity in variety. Secondly, a means to aggregate the results of each analysis is proposed to create holistic measurement for static complexity using the Single Multi-Attribute Ranking Technique (SMART). Each method of static complexity analysis and the aggregation technique is demonstrated using notional data for four lunar oxygen production processes.

  18. Hepatic pathologies in the brackish water catfish (Chrysichthys nigrodigitatus) from contaminated locations of the Lagos lagoon complex

    Science.gov (United States)

    Olarinmoye, O.; Taiwo, V.; Clarke, E.; Kumolu-Johnson, C.; Aderinola, O.; Adekunbi, F.

    2010-01-01

    Several toxicological studies into the effects of aquatic pollutants on the liver of teleost fish exist in literature. The focus on the liver in these studies is predicated on its central nature in the scheme of biotransformation and excretion of xenobiotics following exposure in polluted water bodies. As a consequence of the latter primary role of the liver in these processes it is regarded as a predilective site for the sub lethal effects of xenobiotics on the organism usually detectable at histological level. Hepatic histopathology recorded in livers from feral populations of the brackish water catfish Chrysichthys nigrodigitatus from locations on the Lagos lagoon complex with significant anthropogenic inputs from denizen populations and industries are presented. Liver sections from sixty specimens from two locations on the Lagos lagoon complex (Badagry lagoon: 6??24'N, 2??56'E; and Lagos lagoon: 6??29'N, 3??22'E) were analysed. Observed pathologies included hydropic degeneration (58%), portal / sinusoidal congestion (33%), hepatic necrosis (26%), hemosiderosis (12%) and foci of cellular alterations (FCA's). No obvious oncologic features were observed; the presence of the hydropic Vacuolation lesion was taken as prelude to the development of neoplasms and discussed as such. ?? 2009, Penkala Bt., Budapest, Hungary.

  19. Green facility location

    NARCIS (Netherlands)

    Velázquez Martínez, J.C.; Fransoo, J.C.; Bouchery, Y.; Corbett, C.J.; Fransoo, J.C.; Tan, T.

    2017-01-01

    Transportation is one of the main contributing factors of global carbon emissions, and thus, when dealing with facility location models in a distribution context, transportation emissions may be substantially higher than the emissions due to production or storage. Because facility location models

  20. Analysis of Product Complexity considering Disruption Cost in Fast Fashion Supply Chain

    OpenAIRE

    Sardar, Shaheen; Lee, Young Hae

    2015-01-01

    Outsourcing in the textile industry has been playing an important role in the global economy for six decades. Recently, reshoring is an emerging trend due to various complexities involved in supply chain management. As compared with basic textile and apparel products, fast fashion products are complex in their own way. A single assortment contains several new styles, colors, and sizes with unpredictable demand and urgent deadlines. Numerous assortments run simultaneously in the supply chain. ...

  1. Exporting Complex Digital Products: Motives and Entry Modes

    DEFF Research Database (Denmark)

    Rask, Morten

    2005-01-01

    When the product is digital, it will most often be distributed directly to the customer through the Internet, and therefore the entry modes, considered in this paper, are different flavors of the entry mode called direct export: Virtual export channel are generally understood as the entry mode fo...... for digital product providers. However other types of entry modes like what wee call direct digital export with F2F-sales, direct digital export with F2F-support and virtual sales subsidiary are entry modes that respond to a higher degree of pre- and after-sales complexity....

  2. Natural Product Screening Reveals Naphthoquinone Complex I Bypass Factors.

    Directory of Open Access Journals (Sweden)

    Scott B Vafai

    Full Text Available Deficiency of mitochondrial complex I is encountered in both rare and common diseases, but we have limited therapeutic options to treat this lesion to the oxidative phosphorylation system (OXPHOS. Idebenone and menadione are redox-active molecules capable of rescuing OXPHOS activity by engaging complex I-independent pathways of entry, often referred to as "complex I bypass." In the present study, we created a cellular model of complex I deficiency by using CRISPR genome editing to knock out Ndufa9 in mouse myoblasts, and utilized this cell line to develop a high-throughput screening platform for novel complex I bypass factors. We screened a library of ~40,000 natural product extracts and performed bioassay-guided fractionation on a subset of the top scoring hits. We isolated four plant-derived 1,4-naphthoquinone complex I bypass factors with structural similarity to menadione: chimaphilin and 3-chloro-chimaphilin from Chimaphila umbellata and dehydro-α-lapachone and dehydroiso-α-lapachone from Stereospermum euphoroides. We also tested a small number of structurally related naphthoquinones from commercial sources and identified two additional compounds with complex I bypass activity: 2-methoxy-1,4-naphthoquinone and 2-methoxy-3-methyl-1,4,-naphthoquinone. The six novel complex I bypass factors reported here expand this class of molecules and will be useful as tool compounds for investigating complex I disease biology.

  3. Onderzoek Location Based Marketing: Mobile = location = effect

    NARCIS (Netherlands)

    Gisbergen, M.S. van; Huhn, A.E.; Khan, V.J.; Ketelaar, P.E.

    2011-01-01

    Onderzoekers van de NHTV (Internationaa Hoger Onderwijs Breda, Radboud Universiteit, DVJ Insights en Popai Benelux lieten consumenten in een virtuele supermarkt advertenties via de smartphone ontvangen wanneer men langs het geadverteerde product liep. De uitkomsten laten zien dat 'location based

  4. Location Systems An Introduction to the Technology Behind Location Awareness

    CERN Document Server

    LaMarca, Anthony

    2008-01-01

    Advances in electronic location technology and the coming of age of mobile computing have opened the door for location-aware applications to permeate all aspects of everyday life. Location is at the core of a large number of high-value applications ranging from the life-and-death context of emergency response to serendipitous social meet-ups. For example, the market for GPS products and services alone is expected to grow to US200 billion by 2015. Unfortunately, there is no single location technology that is good for every situation and exhibits high accuracy, low cost, and universal coverage.

  5. Decompositions of the polyhedral product functor with applications to moment-angle complexes and related spaces.

    Science.gov (United States)

    Bahri, A; Bendersky, M; Cohen, F R; Gitler, S

    2009-07-28

    This article gives a natural decomposition of the suspension of a generalized moment-angle complex or partial product space which arises as the polyhedral product functor described below. The introduction and application of the smash product moment-angle complex provides a precise identification of the stable homotopy type of the values of the polyhedral product functor. One direct consequence is an analysis of the associated cohomology. For the special case of the complements of certain subspace arrangements, the geometrical decomposition implies the homological decomposition in earlier work of others as described below. Because the splitting is geometric, an analogous homological decomposition for a generalized moment-angle complex applies for any homology theory. Implied, therefore, is a decomposition for the Stanley-Reisner ring of a finite simplicial complex, and natural generalizations.

  6. Herbal complex of green buckwheat in the production technology of cakes

    Directory of Open Access Journals (Sweden)

    L. E. Glagoleva

    2016-01-01

    Full Text Available The possibility of using vegetable complex of green buckwheat in production technology cheesecakes. The unique chemical, rich mineral and vitamin composition buckwheat green indicates desirability of not only its use, but also th e possibility of using for cooking preventive and functional orientation. Using green buckwheat plant complex due to the hi gh water-holding ability to reduce the time of the process, eliminate some technological preparatory operations, such as pressing off. It is found that the maximum degree of swelling (2.5 g/g was observed at 40 oC and pH 4, 2. The time to reach an equilibrium state is reached after 30 minutes. On the basis of the research has been defined in a way to make plant complex curd basis, in an amount of from 10 to 70 % based on standardized physical-chemical and organoleptic characteristics of harmonious order to minimize-if-operation of flour to make the product functional and preventive properties. Technology of production of a pre -from adequate use of shock freezing, thus preserving the shape, color and flavor of the product. Microbiologists -cal studies analyzed frozen semi-finished products indicates that the microbiological-cal indicators remain stable throughout the shelf life. The use of herbal ingredients in the development of technology and the adjustment of the nutritional value of cheese bioproducts will solve the issue of their care-enrichment in essential micronutrients and natural way to improve the taste and increase the life -sti Useful developed products that currently is a modern and topical focus of research.

  7. Local and regional minimum 1D models for earthquake location and data quality assessment in complex tectonic regions: application to Switzerland

    International Nuclear Information System (INIS)

    Husen, S.; Clinton, J. F.; Kissling, E.

    2011-01-01

    One-dimensional (1D) velocity models are still widely used for computing earthquake locations at seismological centers or in regions where three-dimensional (3D) velocity models are not available due to the lack of data of sufficiently high quality. The concept of the minimum 1D model with appropriate station corrections provides a framework to compute initial hypocenter locations and seismic velocities for local earthquake tomography. Since a minimum 1D model represents a solution to the coupled hypocenter-velocity problem it also represents a suitable velocity model for earthquake location and data quality assessment, such as evaluating the consistency in assigning pre-defined weighting classes and average picking error. Nevertheless, the use of a simple 1D velocity structure in combination with station delays raises the question of how appropriate the minimum 1D model concept is when applied to complex tectonic regions with significant three-dimensional (3D) variations in seismic velocities. In this study we compute one regional minimum 1D model and three local minimum 1D models for selected subregions of the Swiss Alpine region, which exhibits a strongly varying Moho topography. We compare the regional and local minimum 1D models in terms of earthquake locations and data quality assessment to measure their performance. Our results show that the local minimum 1D models provide more realistic hypocenter locations and better data fits than a single model for the Alpine region. We attribute this to the fact that in a local minimum 1D model local and regional effects of the velocity structure can be better separated. Consequently, in tectonically complex regions, minimum 1D models should be computed in sub-regions defined by similar structure, if they are used for earthquake location and data quality assessment. (authors)

  8. Local and regional minimum 1D models for earthquake location and data quality assessment in complex tectonic regions: application to Switzerland

    Energy Technology Data Exchange (ETDEWEB)

    Husen, S.; Clinton, J. F. [Swiss Seismological Service, ETH Zuerich, Zuerich (Switzerland); Kissling, E. [Institute of Geophysics, ETH Zuerich, Zuerich (Switzerland)

    2011-10-15

    One-dimensional (1D) velocity models are still widely used for computing earthquake locations at seismological centers or in regions where three-dimensional (3D) velocity models are not available due to the lack of data of sufficiently high quality. The concept of the minimum 1D model with appropriate station corrections provides a framework to compute initial hypocenter locations and seismic velocities for local earthquake tomography. Since a minimum 1D model represents a solution to the coupled hypocenter-velocity problem it also represents a suitable velocity model for earthquake location and data quality assessment, such as evaluating the consistency in assigning pre-defined weighting classes and average picking error. Nevertheless, the use of a simple 1D velocity structure in combination with station delays raises the question of how appropriate the minimum 1D model concept is when applied to complex tectonic regions with significant three-dimensional (3D) variations in seismic velocities. In this study we compute one regional minimum 1D model and three local minimum 1D models for selected subregions of the Swiss Alpine region, which exhibits a strongly varying Moho topography. We compare the regional and local minimum 1D models in terms of earthquake locations and data quality assessment to measure their performance. Our results show that the local minimum 1D models provide more realistic hypocenter locations and better data fits than a single model for the Alpine region. We attribute this to the fact that in a local minimum 1D model local and regional effects of the velocity structure can be better separated. Consequently, in tectonically complex regions, minimum 1D models should be computed in sub-regions defined by similar structure, if they are used for earthquake location and data quality assessment. (authors)

  9. Construction of Intelligence Knowledge Map for Complex Product Development

    Directory of Open Access Journals (Sweden)

    Yan-jie LV,

    2013-11-01

    Full Text Available The complex product design and development is an integrated discipline. A lot of knowledge overloads and knowledge trek phenomenon appeared with the raise of product complexity and the explosion of knowledge and information. To improve the utilization efficiency of the knowledge using and shorten the time and effort spent on the Knowledge screening, avoid missing the knowledge, which is required, the paper proposes a method for the intelligence knowledge map construct model based on knowledge requirements and knowledge connection. Analyzing the context information of the user and giving the method of acquiring the knowledge requirement based on the context information and the user’s personal knowledge structure. This method can get the knowledge requirements of the users to generate the knowledge retrieval expressions to obtain the knowledge points and then construct the intelligent knowledge map through the analysis of multiple dimensions and using the knowledge related to the development of aircraft landing gear as an example to verify the feasibility of this method.

  10. Experimental/analytical determination of optimal piezoelectric actuator locations on complex structures based on the actuator power factor

    OpenAIRE

    Bhargava, Adesh

    1995-01-01

    The actuator power factor is defined as the ratio of the total dissipative mechanical power of a PZT actuator to the total supplied electrical power to the PZT actuator. If measured experimentally, it can be used to optinlize the actuator location and configuration for complex structures. The concept of actuator power factor is based on the ability of an integrated induced strain actuator such as a PZT actuator to transfer supplied electrical energy into structural mechanical energy. For a gi...

  11. Complex Incremental Product Innovation in Established Service Firms: A Micro Institutional Perspective

    OpenAIRE

    Vermeulen, Patrick; Bosch, Frans; Volberda, Henk

    2007-01-01

    textabstractMany product innovation studies have described key determinants that should lead to successful incremental product innovation. Despite numerous studies suggesting how incremental product innovation should be successfully undertaken, many firms still struggle with this type of innovation. In this paper, we use an institutional perspective to investigate why established firms in the financial services industry struggle with their complex incremental product innovation efforts. We ar...

  12. Acquisition of locative utterances in Norwegian: structure-building via lexical learning.

    Science.gov (United States)

    Mitrofanova, Natalia; Westergaard, Marit

    2018-03-15

    This paper focuses on the acquisition of locative prepositional phrases in L1 Norwegian. We report on two production experiments with children acquiring Norwegian as their first language and compare the results to similar experiments conducted with Russian children. The results of the experiments show that Norwegian children at age 2 regularly produce locative utterances lacking overt prepositions, with the rate of preposition omission decreasing significantly by age 3. Furthermore, our results suggest that phonologically strong and semantically unambiguous locative items appear earlier in Norwegian children's utterances than their phonologically weak and semantically ambiguous counterparts. This conclusion is confirmed by a corpus study. We argue that our results are best captured by the Underspecified P Hypothesis (UPH; Mitrofanova, 2017), which assumes that, at early stages of grammatical development, the underlying structure of locative utterances is underspecified, with more complex functional representations emerging gradually based on the input. This approach predicts that the rate of acquisition in the domain of locative PPs should be influenced by the lexical properties of individual language-specific grammatical elements (such as frequency, morphological complexity, phonological salience, or semantic ambiguity). Our data from child Norwegian show that this prediction is borne out. Specifically, the results of our study suggest that phonologically more salient and semantically unambiguous items are mastered earlier than their ambiguous and phonologically less salient counterparts, despite the higher frequency of the latter in the input (Clahsen et al., 1996).

  13. Real time information management for improving productivity in metallurgical complexes

    International Nuclear Information System (INIS)

    Bascur, O.A.; Kennedy, J.P.

    1999-01-01

    Applying the latest information technologies in industrial plants has become a serious challenge to management and technical teams. The availability of real time and historical operations information to identify the most critical part of the processing system from mechanical integrity is a must for global plant optimization. Expanded use of plant information on the desktop is a standard tool for revenue improvement, cost reduction, and adherence to production constraints. The industrial component desktop supports access to information for process troubleshooting, continuous improvement and innovation by plant and staff personnel. Collaboration between groups enables the implementation of an overall process effectiveness index based on losses due to equipment availability, production and product quality. The key to designing technology is to use the Internet based technologies created by Microsoft for its marketplace-office automation and the Web. Time derived variables are used for process analysis, troubleshooting and performance assessment. Connectivity between metallurgical complexes, research centers and their business system has become a reality. Two case studies of large integrated mining/metallurgical complexes are highlighted. (author)

  14. Final report for the 190-D complex decontamination and decommissioning

    International Nuclear Information System (INIS)

    Thoren, S.D.

    1996-09-01

    This report documents the decontamination and decommissioning (D ampersand D) of the 190-D complex. (located on the Hanford Site in Richland, Washington). D ampersand D of the 190-D complex included decontaminating and removing hazardous and radiologically contaminated materials; dismantling equipment piping and utility infrastructure; demolishing the structure; and restoring the site. The 100-D Area contains two of the nine inactive plutonium production reactors. The reactor sites are located along the south shore of the Columbia River where the sites cover the northern part of the Hanford Site. The 190-D complex is located in the 100-D Area and is composed of the following seven buildings: 185-D De-aeration Building, 189-D Refrigeration Building, 190-D Tank Room Highbay, 190-D Process Pump Room, 190-DA Process Pump Room Annex, 195-D Vertical Safety Rod Test Tower, 1724-D Underwater Test Facility

  15. 75 FR 28657 - Dell Products LP-Parmer North Location, a Subsidiary of Dell, Inc., Including On-Site Leased...

    Science.gov (United States)

    2010-05-21

    ... Spherion Corporation; Round Rock, TX; Dell Products LP--Parmer North One; Austin, TX; Amended Certification... Products LP--Parmer North Location, a Subsidiary of Dell, Inc., Including On-Site Leased Workers From... Act of 1974, as amended (``Act''), 19 U.S.C. 2273, the Department of Labor issued a Certification of...

  16. Syntactic Complexity Effects in Sentence Production: A Reply to MacDonald, Montag, and Gennari (2016)

    Science.gov (United States)

    Scontras, Gregory; Badecker, William; Fedorenko, Evelina

    2017-01-01

    In our article, "Syntactic complexity effects in sentence production" [Scontras, Badecker, Shank, Lim, & Fedorenko, 2015 (EJ1057757)], we reported two elicited production experiments and argued that there is a cost associated with planning and uttering syntactically complex, object-extracted structures that contain a non-local…

  17. Locations in Television Drama Series

    DEFF Research Database (Denmark)

    Waade, Anne Marit

    2017-01-01

    This special issue is dedicated to the analysis of the increasingly significant role of location as a key element in television drama. In recent years, the popularity of serial television has progressively been tied to the expanded use of location as a central element in productions, both as sett...... mainly been considered as a practical term in film and television productions....

  18. Different Prices for Identical Products? Market Efficiency and the Virtual Location in B2C E-Commerce

    OpenAIRE

    Häring, Julia

    2003-01-01

    This paper analyses market efficiency and the role of the virtual location in digital markets using a data set containing more than 23,000 price observations from the online market for contact lenses as well as detailed information about online retailer and product characteristics. The data allow to implement and test the concept of virtual location. The empirical results reveal evidence for lower prices and less price dispersion among e-retailers in comparison to hybrid retailers, which supp...

  19. Upper bounds on quantum uncertainty products and complexity measures

    Energy Technology Data Exchange (ETDEWEB)

    Guerrero, Angel; Sanchez-Moreno, Pablo; Dehesa, Jesus S. [Department of Atomic, Molecular and Nuclear Physics, University of Granada, Granada (Spain); Department of Applied Mathematics, University of Granada, Granada (Spain) and Institute Carlos I for Computational and Theoretical Physics, University of Granada, Granada (Spain); Department of Atomic, Molecular and Nuclear Physics, University of Granada, Granada (Spain); Institute Carlos I for Computational and Theoretical Physics, University of Granada, Granada (Spain)

    2011-10-15

    The position-momentum Shannon and Renyi uncertainty products of general quantum systems are shown to be bounded not only from below (through the known uncertainty relations), but also from above in terms of the Heisenberg-Kennard product . Moreover, the Cramer-Rao, Fisher-Shannon, and Lopez-Ruiz, Mancini, and Calbet shape measures of complexity (whose lower bounds have been recently found) are also bounded from above. The improvement of these bounds for systems subject to spherically symmetric potentials is also explicitly given. Finally, applications to hydrogenic and oscillator-like systems are done.

  20. An efficient fringe integral equation method for optimizing the antenna location on complex bodies

    DEFF Research Database (Denmark)

    Jørgensen, Erik; Meincke, Peter; Breinbjerg, Olav

    2001-01-01

    The radiation pattern of an antenna mounted nearby, or directly on, a complex three-dimensional (3D) structure can be significantly influenced by this structure. Integral equations combined with the method of moments (MoM) provide an accurate means for calculating the scattering from the structures...... in such applications. The structure is then modelled by triangular or rectangular surface patches with corresponding surface current expansion functions. A MoM matrix which is independent of the antenna location can be obtained by modelling the antenna as an impressed electric or magnetic source, e.g., a slot antenna...... can be modelled by a magnetic Hertzian dipole. For flush-mounted antennas, or antennas mounted in close vicinity of the scattering structure, the nearby impressed source induces a highly peaked surface current on the scattering structure. For the low-order basis functions usually applied...

  1. Locating Academic NGOs in the Knowledge Production Landscape

    Directory of Open Access Journals (Sweden)

    Pratyoush Onta

    2012-06-01

    Full Text Available Academic non-governmental organizations (NGOs are already one of the most important institutional sites of knowledge production in the countries of the global South. This article defines academic NGOs as those NGOs which produce not only documentation but also academically engaging articles, reports, edited volumes, bibliographies, journals and monographs. It argues that their growth in the recent decades has taken place amidst the mammoth growth in the number of NGOs in general for structural and personal reasons. A case study from Nepal is provided to illustrate, both at the level of procedures and at the level of outcomes, the kinds of contributions academic NGOs have made to the knowledge enterprise. The article ends by suggesting that the links between editorial control over what academic NGOs produce and the funding they receive are more complex than is usually assumed, and that the issue of their accountability needs to be rendered in a multiple-constituency model similar to that at work in conventional universities.DOI: http://dx.doi.org/10.3126/dsaj.v5i0.6356 Dhaulagiri Journal of Sociology and Anthropology Vol. 5, 2011: 49-80   

  2. Genetic Algorithm for Solving Location Problem in a Supply Chain Network with Inbound and Outbound Product Flows

    Directory of Open Access Journals (Sweden)

    Suprayogi Suprayogi

    2016-12-01

    Full Text Available This paper considers a location problem in a supply chain network. The problem addressed in this paper is motivated by an initiative to develop an efficient supply chain network for supporting the agricultural activities. The supply chain network consists of regions, warehouses, distribution centers, plants, and markets. The products include a set of inbound products and a set of outbound products. In this paper, definitions of the inbound and outbound products are seen from the region’s point of view.  The inbound product is the product demanded by regions and produced by plants which flows on a sequence of the following entities: plants, distribution centers, warehouses, and regions. The outbound product is the product demanded by markets and produced by regions and it flows on a sequence of the following entities: regions, warehouses, and markets. The problem deals with determining locations of the warehouses and the distribution centers to be opened and shipment quantities associated with all links on the network that minimizes the total cost. The problem can be considered as a strategic supply chain network problem. A solution approach based on genetic algorithm (GA is proposed. The proposed GA is examined using hypothetical instances and its results are compared to the solution obtained by solving the mixed integer linear programming (MILP model. The comparison shows that there is a small gap (0.23%, on average between the proposed GA and MILP model in terms of the total cost. The proposed GA consistently provides solutions with least total cost. In terms of total cost, based on the experiment, it is demonstrated that coefficients of variation are closed to 0.

  3. Functional connectivity supporting the selective maintenance of feature-location binding in visual working memory

    Directory of Open Access Journals (Sweden)

    Sachiko eTakahama

    2014-06-01

    Full Text Available Information on an object’s features bound to its location is very important for maintaining object representations in visual working memory. Interactions with dynamic multi-dimensional objects in an external environment require complex cognitive control, including the selective maintenance of feature-location binding. Here, we used event-related functional magnetic resonance imaging to investigate brain activity and functional connectivity related to the maintenance of complex feature-location binding. Participants were required to detect task-relevant changes in feature-location binding between objects defined by color, orientation, and location. We compared a complex binding task requiring complex feature-location binding (color-orientation-location with a simple binding task in which simple feature-location binding, such as color-location, was task-relevant and the other feature was task-irrelevant. Univariate analyses showed that the dorsolateral prefrontal cortex (DLPFC, hippocampus, and frontoparietal network were activated during the maintenance of complex feature-location binding. Functional connectivity analyses indicated cooperation between the inferior precentral sulcus (infPreCS, DLPFC, and hippocampus during the maintenance of complex feature-location binding. In contrast, the connectivity for the spatial updating of simple feature-location binding determined by reanalyzing the data from Takahama et al. (2010 demonstrated that the superior parietal lobule (SPL cooperated with the DLPFC and hippocampus. These results suggest that the connectivity for complex feature-location binding does not simply reflect general memory load and that the DLPFC and hippocampus flexibly modulate the dorsal frontoparietal network, depending on the task requirements, with the infPreCS involved in the maintenance of complex feature-location binding and the SPL involved in the spatial updating of simple feature-location binding.

  4. Arene activation by a nonheme iron(III)-hydroperoxo complex: pathways leading to phenol and ketone products.

    Science.gov (United States)

    Faponle, Abayomi S; Banse, Frédéric; de Visser, Sam P

    2016-07-01

    Iron(III)-hydroperoxo complexes are found in various nonheme iron enzymes as catalytic cycle intermediates; however, little is known on their catalytic properties. The recent work of Banse and co-workers on a biomimetic nonheme iron(III)-hydroperoxo complex provided evidence of its involvement in reactivity with arenes. This contrasts the behavior of heme iron(III)-hydroperoxo complexes that are known to be sluggish oxidants. To gain insight into the reaction mechanism of the biomimetic iron(III)-hydroperoxo complex with arenes, we performed a computational (density functional theory) study. The calculations show that iron(III)-hydroperoxo reacts with substrates via low free energies of activation that should be accessible at room temperature. Moreover, a dominant ketone reaction product is observed as primary products rather than the thermodynamically more stable phenols. These product distributions are analyzed and the calculations show that charge interaction between the iron(III)-hydroxo group and the substrate in the intermediate state pushes the transferring proton to the meta-carbon atom of the substrate and guides the selectivity of ketone formation. These studies show that the relative ratio of ketone versus phenol as primary products can be affected by external interactions of the oxidant with the substrate. Moreover, iron(III)-hydroperoxo complexes are shown to selectively give ketone products, whereas iron(IV)-oxo complexes will react with arenes to form phenols instead.

  5. FEDERAL USERS CONFERENCE PRODUCT LINE TOOL SET (PLTS) MAP PRODUCTION SYSTEM (MPS) ATLAS CUSTOM GRIDS [Rev 0 was draft

    Energy Technology Data Exchange (ETDEWEB)

    HAYENGA, J.L.

    2006-12-19

    Maps, and more importantly Atlases, are assisting the user community in managing a large land area with complex issues, the most complex of which is the management of nuclear waste. The techniques and experiences discussed herein were gained while developing several atlases for use at the US Department of Energy's Hanford Site. The user community requires the ability to locate not only waste sites, but other features as well. Finding a specific waste site on a map and in the field is a difficult task at a site the size of Hanford. To find a specific waste site, the user begins by locating the item or object in an index, then locating the feature on the corresponding map within an atlas. Locating features requires a method for indexing them. The location index and how to place it on a map or atlas is the central theme presented in this article. The user requirements for atlases forced the design team to develop new and innovative solutions for requirements that Product Line Tool Set (PLTS) Map Production System (MPS)-Atlas was not designed to handle. The layout of the most complex atlases includes custom reference grids, multiple data frames, multiple map series, and up to 250 maps. All of these functional requirements are at the extreme edge of the capabilities of PLTS MPS-Atlas. This document outlines the setup of an atlas using PLTS MPS-Atlas to meet these requirements.

  6. FEDERAL USERS CONFERENCE PRODUCT LINE TOOL SET (PLTS) MAP PRODUCTION SYSTEM (MPS) ATLAS CUSTOM GRIDS [Rev 0 was draft

    International Nuclear Information System (INIS)

    HAYENGA, J.L.

    2006-01-01

    Maps, and more importantly Atlases, are assisting the user community in managing a large land area with complex issues, the most complex of which is the management of nuclear waste. The techniques and experiences discussed herein were gained while developing several atlases for use at the US Department of Energy's Hanford Site. The user community requires the ability to locate not only waste sites, but other features as well. Finding a specific waste site on a map and in the field is a difficult task at a site the size of Hanford. To find a specific waste site, the user begins by locating the item or object in an index, then locating the feature on the corresponding map within an atlas. Locating features requires a method for indexing them. The location index and how to place it on a map or atlas is the central theme presented in this article. The user requirements for atlases forced the design team to develop new and innovative solutions for requirements that Product Line Tool Set (PLTS) Map Production System (MPS)-Atlas was not designed to handle. The layout of the most complex atlases includes custom reference grids, multiple data frames, multiple map series, and up to 250 maps. All of these functional requirements are at the extreme edge of the capabilities of PLTS MPS-Atlas. This document outlines the setup of an atlas using PLTS MPS-Atlas to meet these requirements

  7. The frequency of down's syndrome in the city of Ozyorsk located near the nuclear complex ''Mayak''

    International Nuclear Information System (INIS)

    Petrushkina, N.P.; Okatenko, P.V.; Kabirova, N.R.; Koshurnikova, N.A.

    2000-01-01

    The aim of the study is to assess the frequency of Down's syndrome (DS) among newborns in the city of Ozyorsk located near the nuclear complex Mayak''. The study has been conducted on the basis of the cohort, which includes 18,499 children born in Ozyorsk in 1974-1988. Information on cases of DS has been abstracted from newborn records at the city maternity hospital. The frequency of DS in Ozyorsk is 1.4 cases per 1,000 newborns. According to some published data, the population frequency of this syndrome is 1.25-1.42 cases per 1,000 newborns. The frequency of DS among children whose parents were occupationally exposed to radiation has been studied. The cohort has been divided into two subcohorts based on whether or not parents worked at Mayak. In 5,303 children either one or both parents worked at Mayak. The comparison group includes 13,196 children whose parents never worked at Mayak. In the children, whose parents worked at Mayak, the frequency of DS is 1.32 cases per 1000, and in the comparison group - 1.44 cases per 1000 (the difference is not statistically significant). Parental radiation doses by the time of conception of children with DS are in the range from 0.65 to 10.31 cSv. Our data confirm the effect of maternal age on the frequency of DS. The frequency of DS in children born to mother under the age of 30 is 0.94 per 1,000 and in children born to mothers older than 30 years - 3.87 per 1,000. So the frequency of DS among children born in the city located near the nuclear complex does not exceed the spontaneous level. No association has been detected between the frequency of DS and preconception parental radiation exposure. The effect of maternal age has been confirmed. (author)

  8. Lattice location of impurities in silicon Carbide

    CERN Document Server

    AUTHOR|(CDS)2085259; Correia Martins, João Guilherme

    The presence and behaviour of transition metals (TMs) in SiC has been a concern since the start of producing device-grade wafers of this wide band gap semiconductor. They are unintentionally introduced during silicon carbide (SiC) production, crystal growth and device manufacturing, which makes them difficult contaminants to avoid. Once in SiC they easily form deep levels, either when in the isolated form or when forming complexes with other defects. On the other hand, using intentional TM doping, it is possible to change the electrical, optical and magnetic properties of SiC. TMs such as chromium, manganese or iron have been considered as possible candidates for magnetic dopants in SiC, if located on silicon lattice sites. All these issues can be explored by investigating the lattice site of implanted TMs. This thesis addresses the lattice location and thermal stability of the implanted TM radioactive probes 56Mn, 59Fe, 65Ni and 111Ag in both cubic 3C- and hexagonal 6H SiC polytypes by means of emission cha...

  9. The Benefits of Franchising and Vertical Disintergration in Monopolistic Competition for Locationally Differentiated Products

    OpenAIRE

    Nicholas Economides

    1993-01-01

    A model of franchising competition in locationally differentiated products is constructed. A franchisor (upstream firm) collects a marginal transfer fee per unit of output sold by a franchisee (downstream firm). For example, the marginal transfer fee can be realized as a markup on variable inputs supplied by the franchisor. A franchisor also collects a lump-sum rent (commonly called "franchising fee") from each franchisee. Acting in the first stage, a franchisor can manipulate the degree of c...

  10. Characterizing and locating air pollution sources in a complex industrial district using optical remote sensing technology and multivariate statistical modeling.

    Science.gov (United States)

    Chang, Pao-Erh Paul; Yang, Jen-Chih Rena; Den, Walter; Wu, Chang-Fu

    2014-09-01

    Emissions of volatile organic compounds (VOCs) are most frequent environmental nuisance complaints in urban areas, especially where industrial districts are nearby. Unfortunately, identifying the responsible emission sources of VOCs is essentially a difficult task. In this study, we proposed a dynamic approach to gradually confine the location of potential VOC emission sources in an industrial complex, by combining multi-path open-path Fourier transform infrared spectrometry (OP-FTIR) measurement and the statistical method of principal component analysis (PCA). Close-cell FTIR was further used to verify the VOC emission source by measuring emitted VOCs from selected exhaust stacks at factories in the confined areas. Multiple open-path monitoring lines were deployed during a 3-month monitoring campaign in a complex industrial district. The emission patterns were identified and locations of emissions were confined by the wind data collected simultaneously. N,N-Dimethyl formamide (DMF), 2-butanone, toluene, and ethyl acetate with mean concentrations of 80.0 ± 1.8, 34.5 ± 0.8, 103.7 ± 2.8, and 26.6 ± 0.7 ppbv, respectively, were identified as the major VOC mixture at all times of the day around the receptor site. As the toxic air pollutant, the concentrations of DMF in air samples were found exceeding the ambient standard despite the path-average effect of OP-FTIR upon concentration levels. The PCA data identified three major emission sources, including PU coating, chemical packaging, and lithographic printing industries. Applying instrumental measurement and statistical modeling, this study has established a systematic approach for locating emission sources. Statistical modeling (PCA) plays an important role in reducing dimensionality of a large measured dataset and identifying underlying emission sources. Instrumental measurement, however, helps verify the outcomes of the statistical modeling. The field study has demonstrated the feasibility of

  11. MEASURING ACCURACY AND COMPLEXITY OF AN L2 LEARNER’S ORAL PRODUCTION

    Directory of Open Access Journals (Sweden)

    Teguh Khaerudin

    2015-03-01

    Full Text Available This paper aims at examining the influence of different tasks on the degree of task performance in a second language learner’s oral production. The underlying assumption is that among the three aspects of language performance in L2, i.e. fluency, accuracy, and complexity, learners may prioritize only one of them (Ellis & Barkhuizen, 2005, p. 150 and that their decision to prioritize one particular area of language performance may be determined by the characteristics of the task given to the learners (Skehan & Foster, 1997. Having a written record of an oral production, the writer focuses this study on determining the degree of complexity and accuracy, and analyzing whether the different tasks change the level of learner’s oral performance. The results show that learner’s accuracy from both tasks remains in the same level. However, both task conditions, which do not allow speech plan, result in no improvement in accuracy level and a minor improvement in the complexity level.

  12. Uranium Location Database

    Data.gov (United States)

    U.S. Environmental Protection Agency — A GIS compiled locational database in Microsoft Access of ~15,000 mines with uranium occurrence or production, primarily in the western United States. The metadata...

  13. Mitochondrial Complex I superoxide production is attenuated by uncoupling

    Czech Academy of Sciences Publication Activity Database

    Dlasková, Andrea; Hlavatá, Lydie; Ježek, Jan; Ježek, Petr

    2008-01-01

    Roč. 40, č. 10 (2008), s. 2098-2109 ISSN 1357-2725 R&D Projects: GA ČR GP303/05/P100; GA AV ČR IAA500110701; GA MŠk(CZ) 1P05ME794 Institutional research plan: CEZ:AV0Z50110509 Keywords : mitochondrial H2O2 production * mitochondrial Complex I proton pumping * uncoupling Subject RIV: CE - Biochemistry Impact factor: 4.178, year: 2008

  14. Importance of iron complexation for Fenton-mediated hydroxyl radical production at circumneutral pH

    Directory of Open Access Journals (Sweden)

    Christopher J. Miller

    2016-08-01

    Full Text Available The reaction between Fe(II and H2O2 to yield hydroxyl radicals (HO•, the Fenton reaction, is of interest due to its role in trace metal and natural organic matter biogeochemistry, its utility in water treatment and its role in oxidative cell degradation and associated human disease. There is significant dispute over whether HO•, the most reactive of the so-called reactive oxygen species, is formed in this reaction, particularly under circumneutral conditions relevant to natural systems. In this work we have studied the oxidation kinetics of Fe(II complexed by L = citrate, ethylenediaminetetraacetic acid (EDTA and diethylenetriaminepentaacetic acid (DTPA and also measured HO• production using phthalhydrazide as a probe compound at pH 8.2. It is shown that HO• is the sole product of the Fe(IIL-H2O2 reaction for L = EDTA and DTPA, with kinetic modelling of the full reaction pathway utilized to confirm this finding. Quantitative HO• production also appears likely for L = citrate, although uncertainties with the speciation of Fe(II-citrate complexes as well as difficulties in modelling the oxidation kinetics of these complexes has prevented a definitive conclusion. In the absence of ligands at circumneutral pH, inorganic Fe(II reacts with H2O2 to yield a species other than HO•, contrary to the well-established production of HO• from inorganic Fe(II at low pH. Our results suggest that at high pH Fe(II must be complexed for HO• production to occur.

  15. Using embedded design structures to unravel a complex decision in a product development system

    DEFF Research Database (Denmark)

    McKay, Alison; Sammonds, George; Ahmed-Kristensen, Saeema

    2017-01-01

    because of ambiguity in available design definitions. This paper reports research that investigated the role of complex decision making in a quality incident that occurred in the development of a complex product system. A case study approach with document analysis and semi-structured interviews was used....... Data were analysed using lenses from both social sciences and engineering design. In this paper, we report the use of embedded design structures to gain insights into the downstream consequences of design decisions. Results indicate that embedded product, process and supply network structures have......Early design decisions have an impact on downstream product development processes. Poor decisions can reduce efficiency and effectiveness, and have a detrimental effect on product quality, delivery time, and cost. However, the range of tools suitable for use in early design is limited, in part...

  16. A rhodium(III) complex inhibits LPS-induced nitric oxide production and angiogenic activity in cellulo.

    Science.gov (United States)

    Liu, Li-Juan; Lin, Sheng; Chan, Daniel Shiu-Hin; Vong, Chi Teng; Hoi, Pui Man; Wong, Chun-Yuen; Ma, Dik-Lung; Leung, Chung-Hang

    2014-11-01

    Metal-containing complexes have arisen as viable alternatives to organic molecules as therapeutic agents. Metal complexes possess a number of advantages compared to conventional carbon-based compounds, such as distinct geometries, interesting electronic properties, variable oxidation states and the ability to arrange different ligands around the metal centre in a precise fashion. Meanwhile, nitric oxide (NO) plays key roles in the regulation of angiogenesis, vascular permeability and inflammation. We herein report a novel cyclometalated rhodium(III) complex as an inhibitor of lipopolysaccharides (LPS)-induced NO production in RAW264.7 macrophages. Experiments suggested that the inhibition of NO production in cells by complex 1 was mediated through the down-regulation of nuclear factor-κB (NF-κB) activity. Furthermore, complex 1 inhibited angiogenesis in human umbilical vein endothelial cells (HUVECs) as revealed by an endothelial tube formation assay. This study demonstrates that kinetically inert rhodium(III) complexes may be potentially developed as effective anti-angiogenic agents. Copyright © 2014 Elsevier Inc. All rights reserved.

  17. High yielding tropical energy crops for bioenergy production: Effects of plant components, harvest years and locations on biomass composition.

    Science.gov (United States)

    Surendra, K C; Ogoshi, Richard; Zaleski, Halina M; Hashimoto, Andrew G; Khanal, Samir Kumar

    2018-03-01

    The composition of lignocellulosic feedstock, which depends on crop type, crop management, locations and plant parts, significantly affects the conversion efficiency of biomass into biofuels and biobased products. Thus, this study examined the composition of different parts of two high yielding tropical energy crops, Energycane and Napier grass, collected across three locations and years. Significantly higher fiber content was found in the leaves of Energycane than stems, while fiber content was significantly higher in the stems than the leaves of Napier grass. Similarly, fiber content was higher in Napier grass than Energycane. Due to significant differences in biomass composition between the plant parts within a crop type, neither biological conversion, including anaerobic digestion, nor thermochemical pretreatment alone is likely to efficiently convert biomass components into biofuels and biobased products. However, combination of anaerobic digestion with thermochemical conversion technologies could efficiently utilize biomass components in generating biofuels and biobased products. Copyright © 2017 Elsevier Ltd. All rights reserved.

  18. A Systematic Optimization Design Method for Complex Mechatronic Products Design and Development

    Directory of Open Access Journals (Sweden)

    Jie Jiang

    2018-01-01

    Full Text Available Designing a complex mechatronic product involves multiple design variables, objectives, constraints, and evaluation criteria as well as their nonlinearly coupled relationships. The design space can be very big consisting of many functional design parameters, structural design parameters, and behavioral design (or running performances parameters. Given a big design space and inexplicit relations among them, how to design a product optimally in an optimization design process is a challenging research problem. In this paper, we propose a systematic optimization design method based on design space reduction and surrogate modelling techniques. This method firstly identifies key design parameters from a very big design space to reduce the design space, secondly uses the identified key design parameters to establish a system surrogate model based on data-driven modelling principles for optimization design, and thirdly utilizes the multiobjective optimization techniques to achieve an optimal design of a product in the reduced design space. This method has been tested with a high-speed train design. With comparison to others, the research results show that this method is practical and useful for optimally designing complex mechatronic products.

  19. TEG-Directed Transfusion in Complex Cardiac Surgery: Impact on Blood Product Usage.

    Science.gov (United States)

    Fleming, Kevin; Redfern, Roberta E; March, Rebekah L; Bobulski, Nathan; Kuehne, Michael; Chen, John T; Moront, Michael

    2017-12-01

    Complex cardiac procedures often require blood transfusion because of surgical bleeding or coagulopathy. Thrombelastography (TEG) was introduced in our institution to direct transfusion management in cardiothoracic surgery. The goal of this study was to quantify the effect of TEG on transfusion rates peri- and postoperatively. All patients who underwent complex cardiac surgery, defined as open multiple valve repair/replacement, coronary artery bypass grafting with open valve repair/replacement, or aortic root/arch repair before and after implementation of TEG were identified and retrospectively analyzed. Minimally invasive cases were excluded. Patient characteristics and blood use were compared with t test and chi-square test. A generalized linear model including patient characteristics, preoperative and postoperative lab values, and autotransfusion volume was used to determine the impact of TEG on perioperative, postoperative, and total blood use. In total, 681 patients were identified, 370 in the pre-TEG period and 311 patients post-TEG. Patient demographics were not significantly different between periods. Mean units of red blood cells, plasma, and cryoprecipitate were significantly reduced after TEG was implemented (all, p platelets was reduced but did not reach significance. Mean units of all blood products in the perioperative period and over the entire stay were reduced by approximately 40% (both, p < .0001). Total proportion of patients exposed to transfusion was significantly lower after introduction of TEG ( p < .01). Controlling for related factors on multivariate analysis, such as preoperative laboratory values and autotransfusion volume, use of TEG was associated with significant reduction in perioperative and overall blood product transfusion. TEG-directed management of blood product administration during complex cardiac surgeries significantly reduced the units of blood products received perioperatively but not blood usage more than 24 hours after

  20. Modeling discrete competitive facility location

    CERN Document Server

    Karakitsiou, Athanasia

    2015-01-01

    This book presents an up-to-date review of modeling and optimization approaches for location problems along with a new bi-level programming methodology which captures the effect of competition of both producers and customers on facility location decisions. While many optimization approaches simplify location problems by assuming decision making in isolation, this monograph focuses on models which take into account the competitive environment in which such decisions are made. New insights in modeling, algorithmic and theoretical possibilities are opened by this approach and new applications are possible. Competition on equal term plus competition between market leader and followers are considered in this study, consequently bi-level optimization methodology is emphasized and further developed. This book provides insights regarding modeling complexity and algorithmic approaches to discrete competitive location problems. In traditional location modeling, assignment of customer demands to supply sources are made ...

  1. Modelling the dynamics of the health-production complex in livestock herds

    DEFF Research Database (Denmark)

    Sørensen, J.T.; Enevoldsen, Carsten

    1992-01-01

    This paper reviews how the dynamics of the health-production complex in livestock herds is mimicked by livestock herd simulation models. Twelve models simulating the dynamics of dairy, beef, sheep and sow herds were examined. All models basically included options to alter input and output...

  2. Anatomy of a decision trap in complex new product development projects

    NARCIS (Netherlands)

    van Oorschot, K.E.; Akkermans, H.A.; Sengupta, K.; van Wassenhove, L.N.

    2013-01-01

    We conducted a longitudinal process study of one firm's failed attempt to develop a new product. Our extensive data analysis suggests that teams in complex dynamic environments characterized by delays are subject to multiple “information filters” that blur their perception of actual project

  3. Impact of the utilization of a product configuration system on product’s life cycle complexity

    DEFF Research Database (Denmark)

    Myrodia, Anna; Kristjansdottir, Katrin; Shafiee, Sara

    The purpose of this paper is to identify areas throughout a product’s lifecycle processes where complexity can be reduced by implementing a product configuration system (PCS). As discussed in the literature, several benefits are realized by using a PCS in terms of product and process standardizat...... for the company in several life cycle processes....... standardization. This also leads to control and reduce of complexity both in products and processes. To this end, this research attempts to quantify and assess these benefits and is supported by empirical evidence. A case study of an engineering company is used and the results indicate significant improvements...

  4. Childhood mortality in the city located near the nuclear complex ''Mayak''

    International Nuclear Information System (INIS)

    Petrushkina, N.P.; Okatenko, P.V.; Kabirova, N.R.; Koshurnikova, N.A.; Kuropatenko, E.S.; Ziryanov, A.G.

    2000-01-01

    The purpose of the study is to assess possible health effects associated with technogenic radiation exposure due to residence near a nuclear complex. The study cohort includes 10,478 children born between 1974 and 1981 and living in the city of Ozyorsk, which is located near the nuclear complex Mayak''. The comparison cohort includes 6,217 children born in the same period and living in the city of Snezhinsk, which is similar to Ozyorsk with respect to its infrastructure and the quality of medical care, and differs from Ozyorsk with respect to the level of radiation exposure to the population. Average value of accumulated effective dose resulted from Mayak operation in the children of Ozyorsk is 2.2 mSv (from 0.05 to 3.4 mSv), and in the children of Snezhinsk - 1.3 mSv (from 0.07 to 2.0 mSv). This difference in doses is related to larger distance of Snezhinsk from Mayak. The number of person-years of follow-up is 135,778 in the study cohort and 82,232 in the comparison cohort. The mortality rate between 1 and 15 years of age is 44.9±5.7 deaths per 10 5 person-years (PY) in Ozyorsk and 29.2±6.0 deaths per 10 5 PY in Snezhinsk. The difference is not statistically significant. The structure of mortality is similar in the study and comparison cohorts. Major causes of deaths in both cities are external causes, neoplasms and respiratory diseases. Mortality from all malignant neoplasms is 9.6 deaths per 10 5 PY (Ozyorsk) and 4.9 deaths per 10 5 PY (Snezhinsk), including leukemia mortality 3.7 deaths per 10 5 PY and 2.4 deaths per 10 5 PY in Ozyorsk and Snezhinsk respectively (the differences are not statistically significant). Comparison of age-specific childhood mortality rates in the study cohort with those in the urban population of Russia shows, that cancer mortality in the study cohort is on the level of national average values almost in all age groups, whereas mortality from non-cancer diseases, external causes and respiratory diseases is considerably lower, than

  5. A systems engineering approach to manage the complexity in sustainable chemical product-process design

    DEFF Research Database (Denmark)

    Gani, Rafiqul

    This paper provides a perspective on model-data based solution approaches for chemical product-process design, which consists of finding the identity of the candidate chemical product, designing the process that can sustainably manufacture it and verifying the performance of the product during...... framework can manage the complexity associated with product-process problems very efficiently. Three specific computer-aided tools (ICAS, Sustain-Pro and VPPDLab) have been presented and their applications to product-process design, highlighted....

  6. Feasibility Study for Co-Locating and Integrating Ethanol Production Plants from Corn Starch and Lignocellulosic Feedstocks (Revised)

    Energy Technology Data Exchange (ETDEWEB)

    Wallace, R.; Ibsen, K.; McAloon, A.; Yee, W.

    2005-01-01

    Analysis of the feasibility of co-locating corn-grain-to-ethanol and lignocellulosic ethanol plants and potential savings from combining utilities, ethanol purification, product processing, and fermentation. Although none of the scenarios identified could produce ethanol at lower cost than a straight grain ethanol plant, several were lower cost than a straight cellulosic ethanol plant.

  7. Location, location, location: Assessing the spatial patterning between marijuana licenses, alcohol outlets and neighborhood characteristics within Washington state.

    Science.gov (United States)

    Tabb, Loni Philip; Fillmore, Christina; Melly, Steven

    2018-04-01

    The availability of marijuana products is becoming increasingly prevalent across the United States (US), many states are allowing for the production, processing, and retailing of these products for medical and/or recreational use. The purpose of this study is to: (1) examine the spatial patterning of marijuana licenses, and (2) examine the impact of alcohol outlets in addition to other neighborhood characteristics on marijuana licenses within the state of Washington. This cross-sectional observational study examined 1458 census tracts in Washington state from 2017, using marijuana and alcohol data from the Washington State Liquor and Cannabis Board as well as neighborhood characteristics data from the American Community Survey 2011-2015 5-year estimates. We used exploratory and formal spatial regression methods, including integrated nested Laplace approximation within a Bayesian statistical framework, to address the study aims. Our results indicate there is significant spatial patterning of marijuana producers and processors across the state. We also found that all marijuana licenses are located in poorer census tracts, and marijuana retailers are co-located in census tracts with off-premises alcohol outlets. Our study provides empirical evidence of the relationship between marijuana licenses, alcohol outlets, and neighborhood characteristics, and has important implications for policymakers in other states currently considering legalizing marijuana-products for medical and/or recreational use. Copyright © 2018 Elsevier B.V. All rights reserved.

  8. Research on the Governance Mechanism of Aviation Complex Product Manufacturing Supply Chain Based on Dynamic Game Theory

    Directory of Open Access Journals (Sweden)

    Wang Nan

    2016-01-01

    Full Text Available In the manufacturing process of aeronautical complex products, for the following problems: develop long production cycle, a large number of ancillary products, a plurality of participating units, etc, and the status of the frequency of quality problems, using single-phase static game model in the case of asymmetric information, study on Supplier Quality insufficient investment, which resulting in opportunistic behaviour reasons. And using KMRW dynamic game model, we quantitative analysis the mechanism and crucial role of reputation mechanisms to ensure aeronautical complex product manufacturing supply chain and effective operation.

  9. Analyzing Integrated Cost-Schedule Risk for Complex Product Systems R&D Projects

    Directory of Open Access Journals (Sweden)

    Zhe Xu

    2014-01-01

    Full Text Available The vast majority of the research efforts in project risk management tend to assess cost risk and schedule risk independently. However, project cost and time are related in reality and the relationship between them should be analyzed directly. We propose an integrated cost and schedule risk assessment model for complex product systems R&D projects. Graphical evaluation review technique (GERT, Monte Carlo simulation, and probability distribution theory are utilized to establish the model. In addition, statistical analysis and regression analysis techniques are employed to analyze simulation outputs. Finally, a complex product systems R&D project as an example is modeled by the proposed approach and the simulation outputs are analyzed to illustrate the effectiveness of the risk assessment model. It seems that integrating cost and schedule risk assessment can provide more reliable risk estimation results.

  10. Interface diagram: Design tool for supporting the development of modularity in complex product systems

    DEFF Research Database (Denmark)

    Bruun, Hans Peter Lomholt; Mortensen, Niels Henrik; Harlou, Ulf

    2014-01-01

    complex when using a mass customisation strategy because standard designs (reusable modules) have to be designed to fit a range of products. This product development set-up requires that engineers working in different technical domains collaborate and are able to share information in a unified way...

  11. Commercial milk distribution profiles and production locations

    International Nuclear Information System (INIS)

    Deonigi, D.E.; Anderson, D.M.; Wilfert, G.L.

    1994-04-01

    The Hanford Environmental Dose Reconstruction (HEDR) Project was established to estimate radiation doses that people could have received from nuclear operations at the Hanford Site since 1944. For this period iodine-131 is the most important offsite contributor to radiation doses from Hanford operations. Consumption of milk from cows that ate vegetation contaminated by iodine-131 is the dominant radiation pathway for individuals who drank milk (Napier 1992). Information has been developed on commercial milk cow locations and commercial milk distribution during 1945 and 1951. The year 1945 was selected because during 1945 the largest amount of iodine-131 was released from Hanford facilities in a calendar year (Heeb 1993); therefore, 1945 was the year in which an individual was likely to have received the highest dose. The year 1951 was selected to provide data for comparing the changes that occurred in commercial milk flows (i.e., sources, processing locations, and market areas) between World War II and the post-war period. To estimate the doses people could have received from this milk flow, it is necessary to estimate the amount of milk people consumed, the source of the milk, the specific feeding regime used for milk cows, and the amount of iodine-131 contamination deposited on feed

  12. The locational implications of management and production fragmentation

    Directory of Open Access Journals (Sweden)

    Carlos Eduardo Lobo e Silva

    2010-09-01

    Full Text Available The main purpose of the work is to provide a theoretical link between the location decision and the internal organization of firms. In the simulation presented, (1 communication costs within the firm and (2 managerial structures affect both the production fragmentation process and the economic specialization of cities. More specifically, as either communication costs diminish or managerial structures become more flexible, manufacturing plants tend to move from the big city to medium cities, whereas headquarters and business services tend to agglomerate in the metropolitan area. The introduction of the internal organization of firms into the model, an aspect that is not modeled by Jones-Kierzkowski's approach, allows this article to formalize some empirical evidences pointed out by the literature.O objetivo central deste trabalho é mostrar a importância que a organização interna das firmas pode ter na decisão de localização das empresas e, consequentemente, no processo de fragmentação espacial da produção. Na simulação proposta, na medida em que os custos de comunicação diminuem ou as estruturas gerenciais se tornam mais flexíveis, as fábricas tendem a se localizar nas cidades médias, enquanto as administrações centrais das firmas se aglomeram nas áreas metropolitanas. A introdução da organização interna das firmas no modelo, um aspecto não levado em conta pela abordagem proposta por Jones e Kierzkowski, permite formalizar evidências empíricas apontadas pela literatura recente.

  13. SOLID WASTE MANAGEMENT IN TABRIZ PETROCHEMICAL COMPLEX

    OpenAIRE

    M. A. Abduli, M. Abbasi, T. Nasrabadi, H. Hoveidi, N. Razmkhah

    2006-01-01

    Tabriz petrochemical complex is located in the northwest of Iran. Major products of this industry include raw plastics like, polyethylene, polystyrene, acrylonitrile, butadiene, styrene, etc. Sources of waste generation include service units, health and cure units, water, power, steam and industrial processes units. In this study, different types of solid waste including hazardous and non hazardous solid wastes were investigated separately. The aim of the study was to focus on the management ...

  14. A Bacillus megaterium System for the Production of Recombinant Proteins and Protein Complexes.

    Science.gov (United States)

    Biedendieck, Rebekka

    2016-01-01

    For many years the Gram-positive bacterium Bacillus megaterium has been used for the production and secretion of recombinant proteins. For this purpose it was systematically optimized. Plasmids with different inducible promoter systems, with different compatible origins, with small tags for protein purification and with various specific signals for protein secretion were combined with genetically improved host strains. Finally, the development of appropriate cultivation conditions for the production strains established this organism as a bacterial cell factory even for large proteins. Along with the overproduction of individual proteins the organism is now also used for the simultaneous coproduction of up to 14 recombinant proteins, multiple subsequently interacting or forming protein complexes. Some of these recombinant strains are successfully used for bioconversion or the biosynthesis of valuable components including vitamins. The titers in the g per liter scale for the intra- and extracellular recombinant protein production prove the high potential of B. megaterium for industrial applications. It is currently further enhanced for the production of recombinant proteins and multi-subunit protein complexes using directed genetic engineering approaches based on transcriptome, proteome, metabolome and fluxome data.

  15. 27 CFR 555.206 - Location of magazines.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 3 2010-04-01 2010-04-01 false Location of magazines. 555... EXPLOSIVES, DEPARTMENT OF JUSTICE EXPLOSIVES COMMERCE IN EXPLOSIVES Storage § 555.206 Location of magazines. (a) Outdoor magazines in which high explosives are stored must be located no closer to inhabited...

  16. Visual Perception-Based Statistical Modeling of Complex Grain Image for Product Quality Monitoring and Supervision on Assembly Production Line.

    Directory of Open Access Journals (Sweden)

    Jinping Liu

    Full Text Available Computer vision as a fast, low-cost, noncontact, and online monitoring technology has been an important tool to inspect product quality, particularly on a large-scale assembly production line. However, the current industrial vision system is far from satisfactory in the intelligent perception of complex grain images, comprising a large number of local homogeneous fragmentations or patches without distinct foreground and background. We attempt to solve this problem based on the statistical modeling of spatial structures of grain images. We present a physical explanation in advance to indicate that the spatial structures of the complex grain images are subject to a representative Weibull distribution according to the theory of sequential fragmentation, which is well known in the continued comminution of ore grinding. To delineate the spatial structure of the grain image, we present a method of multiscale and omnidirectional Gaussian derivative filtering. Then, a product quality classifier based on sparse multikernel-least squares support vector machine is proposed to solve the low-confidence classification problem of imbalanced data distribution. The proposed method is applied on the assembly line of a food-processing enterprise to classify (or identify automatically the production quality of rice. The experiments on the real application case, compared with the commonly used methods, illustrate the validity of our method.

  17. Visual Perception-Based Statistical Modeling of Complex Grain Image for Product Quality Monitoring and Supervision on Assembly Production Line.

    Science.gov (United States)

    Liu, Jinping; Tang, Zhaohui; Zhang, Jin; Chen, Qing; Xu, Pengfei; Liu, Wenzhong

    2016-01-01

    Computer vision as a fast, low-cost, noncontact, and online monitoring technology has been an important tool to inspect product quality, particularly on a large-scale assembly production line. However, the current industrial vision system is far from satisfactory in the intelligent perception of complex grain images, comprising a large number of local homogeneous fragmentations or patches without distinct foreground and background. We attempt to solve this problem based on the statistical modeling of spatial structures of grain images. We present a physical explanation in advance to indicate that the spatial structures of the complex grain images are subject to a representative Weibull distribution according to the theory of sequential fragmentation, which is well known in the continued comminution of ore grinding. To delineate the spatial structure of the grain image, we present a method of multiscale and omnidirectional Gaussian derivative filtering. Then, a product quality classifier based on sparse multikernel-least squares support vector machine is proposed to solve the low-confidence classification problem of imbalanced data distribution. The proposed method is applied on the assembly line of a food-processing enterprise to classify (or identify) automatically the production quality of rice. The experiments on the real application case, compared with the commonly used methods, illustrate the validity of our method.

  18. "The only way is up" : Location and movement in product packaging as predictors of sensorial impressions and brand identity

    NARCIS (Netherlands)

    van Rompay, Thomas J.L.; Fransen, M.L.; Borgelink, B.; Brassett, J.; McDonnell, J.; Malpass, M.; Hekkert, P.P.M.; Ludden, G.D.S.

    2012-01-01

    Based on embodiment research linking visual-spatial design parameters to symbolic meaning portrayal, this study investigates to what extent location of imagery on product packaging and visual devices portraying movement (i.e., an arrow indicating movement along an upward-headed or downward-headed

  19. Product development strategy in the Danish agricultural complex: Global interaction with clusters of marketing excellence

    DEFF Research Database (Denmark)

    Kristensen, Preben Sander

    1992-01-01

    A study of the Danish foods industry shows that producers of food products have built up and maintain development of end-user products in interaction with customers in distant sophisticated markets. Concurrently, the Danish agro-industrial complex been singled out in other studies as a paradigmatic...... produce and utilize sticky and fastchanging information about production and markets respectively. It is precisely by not interacting wi market business-to-business demand from changing end-user market that the Danish agro-industrial complex has avoided being insulated. The managerial implication...... is that a company in search of partners for joint development in global agro-industra networks can realize a competitive advantage by applying a market view that is euclidean upstream and equidstant downstream....

  20. Leveraging Understanding of Flow of Variable Complex Fluid to Design Better Absorbent Hygiene Products

    Science.gov (United States)

    Krautkramer, C.; Rend, R. R.

    2014-12-01

    Menstrual flow, which is a result of shedding of uterus endometrium, occurs periodically in sync with a women's hormonal cycle. Management of this flow while allowing women to pursue their normal daily lives is the purpose of many commercial products. Some of these products, e.g. feminine hygiene pads and tampons, utilize porous materials in achieving their goal. In this paper we will demonstrate different phenomena that have been observed in flow of menstrual fluid through these porous materials, share some of the advances made in experimental and analytical study of these phenomena, and also present some of the unsolved challenges and difficulties encountered while studying this kind of flow. Menstrual fluid is generally composed of four main components: blood plasma, blood cells, cervical mucus, and tissue debris. This non-homogeneous, multiphase fluid displays very complex rheological behavior, e. g., yield stress, thixotropy, and visco-elasticity, that varies throughout and between menstrual cycles and among women due to various factors. Flow rates are also highly variable during menstruation and across the population and the rheological properties of the fluid change during the flow into and through the product. In addition to these phenomena, changes to the structure of the porous medium within the product can also be seen due to fouling and/or swelling of the material. This paper will, also, share how the fluid components impact the flow and the consequences for computer simulation, the creation of a simulant fluid and testing methods, and for designing products that best meet consumer needs. We hope to bring to light the challenges of managing this complex flow to meet a basic need of women all over the world. An opportunity exists to apply learnings from research in other disciplines to improve the scientific knowledge related to the flow of this complex fluid through the porous medium that is a sanitary product.

  1. Conditions of milk production of family farms located in the municipality of Alegre – ES, Brazil

    Directory of Open Access Journals (Sweden)

    Francisca Carvalho Nascimento Neta

    2015-12-01

    Full Text Available The present study aimed to assess the conditions and practices of production of raw milk used by farmers, as well as the conditions of storage and of the facilities and structures of the locations of the four collective cooling tanks, in the municipality of Alegre – ES. Data on sanitization procedures and physical structure of barns, source and treatment of water, hygiene practices and health status of milkers, udder cleaning and disinfection procedures and sanitary control of the herd was collected. The physical structure of the locations of the tanks was also assessed. The barns were ventilated, protected from moisture and had covers, and few had cemented floor and milking parlor. A low percentage of producers performed pre (21% and post (6% dipping procedures. Only 1/4 of the farmers used the mug test. All equipment and tools were washed after milking, but few farmers (5% used sanitizers and 94% of the farms used untreated water. Only 8% of the milkers had the habit of washing their hands before milking, and 9% of them were aware of IN 62 regulation of the Ministry of Agriculture, Livestock and Supply. None of the facilities had protection against the entrance of insects, rodents and environmental contaminants. They were poorly sized, did not allow the application of adequate sanitary measures and sanitary conditions were deficient. The high level of nonconformities regarding good manufacturing practices for milk production reinforced the need for the implementation of Good Agricultural Practices in rural farms for the purpose of obtaining milk produced according to the quality standards, preventing losses and ensuring the sustainability of dairy production in the region.

  2. Complex Technical Solution for Renewable Energy

    Directory of Open Access Journals (Sweden)

    Cristian Paul Chioncel

    2010-01-01

    Full Text Available This paper presents a complex technical solution for implementing renewable energy, namely: wind, solar photovoltaic and hydraulics. Because wind and solar photovoltaic energy habe a highly random character, it is required to find solution to store the product energy for unfavorable periods, without wind or solar radiations. This could be achieved using the third type of renewable energy, the hydraulic one, obtained from an hydroelectric pumped storage plant (HPSP, located in the imediate vicinity of the wind and solar photovoltaic plant.

  3. Probabilistic Data Modeling and Querying for Location-Based Data Warehouses

    DEFF Research Database (Denmark)

    Timko, Igor; Dyreson, Curtis E.; Pedersen, Torben Bach

    Motivated by the increasing need to handle complex, dynamic, uncertain multidimensional data in location-based warehouses, this paper proposes a novel probabilistic data model that can address the complexities of such data. The model provides a foundation for handling complex hierarchical and unc...

  4. Probabilistic Data Modeling and Querying for Location-Based Data Warehouses

    DEFF Research Database (Denmark)

    Timko, Igor; Dyreson, Curtis E.; Pedersen, Torben Bach

    2005-01-01

    Motivated by the increasing need to handle complex, dynamic, uncertain multidimensional data in location-based warehouses, this paper proposes a novel probabilistic data model that can address the complexities of such data. The model provides a foundation for handling complex hierarchical and unc...

  5. Forest resources, government policy, and investment location decisions of the forest products industry in the southern United States

    Science.gov (United States)

    Changyou Sun; Daowei Zhang

    2010-01-01

    In this article, the results of an initial attempt to estimate the effects of state attributes on plant location and investment expenditure were presented for the forest products industry in the southern United States. A conditional logit model was used to analyze new plant births, and a time-series cross-section model to assess the total capital expenditure....

  6. 27 CFR 40.113 - Change in location to another region.

    Science.gov (United States)

    2010-04-01

    ... another region. 40.113 Section 40.113 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND... Products Changes in Location of Factory § 40.113 Change in location to another region. Whenever a manufacturer of tobacco products intends to remove his factory to another region, the manufacturer shall...

  7. The problem of sustainability within the complexity of agricultural production systems

    International Nuclear Information System (INIS)

    Cotes Torres, Alejandro; Cotes Torres, Jose Miguel

    2005-01-01

    The problem of sustainability is a topic that since the end of the XX century has been worrying more the different sectors of society; becoming one of the topics of greatest interest for managers, consumers, academics and investigators that conform the different agricultural food chains of the world. This paper presents from the general systems theory point of view some elements of critical reflection, approaching the problem of sustainability from the complexity of agricultural production systems, beginning with the original philosophical conception of agricultural and ending by outlining some considerations that should be kept in mind for the development of scientific and technological advances concordant with the agricultural food chain needs of the XX century; which permit an orientation of not only work by profession is who lead the processes of animal and vegetable production, but also creates a sense of pertinence in all of the participants in the chain, highlighting the importance of studying by means of systemic thought, agronomy and animal science, as disciplines that approach to complexities of agriculture which is the angular stone of civilization, such as we know it at the moment

  8. 27 CFR 40.111 - Change in location within same region.

    Science.gov (United States)

    2010-04-01

    ... same region. 40.111 Section 40.111 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND... Products Changes in Location of Factory § 40.111 Change in location within same region. Whenever a manufacturer of tobacco products intends to relocate his factory within the same region, the manufacturer shall...

  9. Switching industrial production processes from complex to defined media: method development and case study using the example of Penicillium chrysogenum.

    Science.gov (United States)

    Posch, Andreas E; Spadiut, Oliver; Herwig, Christoph

    2012-06-22

    Filamentous fungi are versatile cell factories and widely used for the production of antibiotics, organic acids, enzymes and other industrially relevant compounds at large scale. As a fact, industrial production processes employing filamentous fungi are commonly based on complex raw materials. However, considerable lot-to-lot variability of complex media ingredients not only demands for exhaustive incoming components inspection and quality control, but unavoidably affects process stability and performance. Thus, switching bioprocesses from complex to defined media is highly desirable. This study presents a strategy for strain characterization of filamentous fungi on partly complex media using redundant mass balancing techniques. Applying the suggested method, interdependencies between specific biomass and side-product formation rates, production of fructooligosaccharides, specific complex media component uptake rates and fungal strains were revealed. A 2-fold increase of the overall penicillin space time yield and a 3-fold increase in the maximum specific penicillin formation rate were reached in defined media compared to complex media. The newly developed methodology enabled fast characterization of two different industrial Penicillium chrysogenum candidate strains on complex media based on specific complex media component uptake kinetics and identification of the most promising strain for switching the process from complex to defined conditions. Characterization at different complex/defined media ratios using only a limited number of analytical methods allowed maximizing the overall industrial objectives of increasing both, method throughput and the generation of scientific process understanding.

  10. Location, location, location: Extracting location value from house prices

    OpenAIRE

    Kolbe, Jens; Schulz, Rainer; Wersing, Martin; Werwatz, Axel

    2012-01-01

    The price for a single-family house depends both on the characteristics of the building and on its location. We propose a novel semiparametric method to extract location values from house prices. After splitting house prices into building and land components, location values are estimated with adaptive weight smoothing. The adaptive estimator requires neither strong smoothness assumptions nor local symmetry. We apply the method to house transactions from Berlin, Germany. The estimated surface...

  11. Metal complexation in near field conditions of nuclear waste repository - stability constant of copper complexation with cellulose degradation products, in alkaline conditions

    International Nuclear Information System (INIS)

    Guede, Kipre Bertin

    2005-11-01

    Copper is a stable element and spent fuel component which constitutes the radioactive waste. The reaction of Copper with cellulose degradation products in alkaline conditions was performed to mimic what occurs in near field conditions of nuclear waste repository. From the characteristics of Cu (II), this thesis aims at inferring the behaviour of radionuclides vis a vis the degradation products of cellulose. The contribution of the present work is therefore the assessment of the stability of the major cellulose degradation product, its affinity for Copper and the extent of the complexation function 13 between Cu (II) and the organic moieties. The formation of cellulose degradation products was followed by measurement of p11, Conductivity, Angle of rotation, relative abundance of aliphatics and aromatics (E4/E6 ) aid by UV-visible spectroscopy. The TOC was determined using the Walkley and Black titration after respectively 31 weeks and 13 weeks of degradation for the reaction mixtures T and A, N. The stability of the major degradation products gave the following figures: ISA(A): - 13 43.39 <ΔG -10639.88 ISA(N): - Ii 436.45<ΔG< -9103.6. The study of the characteristics of Gluconic Acid, as a model compound, was carried out in an attempt to give a general picture of the roper ties of cellulose degradation products. The Complexation between Cu (II) and the organic ligand (Cellulose degradation products) was performed using UV-visible spectroscopy and Ion Distribution technique. The Log B value obtained from the complexation studies at 336 nm for 1 = 0. I Ni NaClO4 and I = 0.01 M NaClO4, falls within a range of 3.48 to 3.74 for the standard reference material (Gluconic Acid), and within I .87 to 2.3 I, and I .6 to 2.01, respectively for the degradation Products ISA (A) and ISA(N). The ion distribution studies showed that: • In (he absence of the degradation product ISA and at pH = 3.68. 56. 17 % of Cu (II) was bound to the resin. • In the presence of ISA and at 2

  12. Location of slaughterhouses under economies of scale

    NARCIS (Netherlands)

    van den Broek, J.J.J.; Schütz, P.; Stougie, L.; Tomasgard, A.

    2006-01-01

    The facility location problem described in this paper comes from an industrial application in the slaughterhouse industry of Norway. Investigations show that the slaughterhouse industry experiences economies of scale in the production facilities. We examine a location-allocation problem focusing on

  13. Decisive management in selecting locations for development of construction projects

    Science.gov (United States)

    Szafranko, E.; Pawłowicz, J. A.

    2017-08-01

    The location of an investment project is one of the most important decisions in the construction and land development business. The shape of a new building and aspects of its future use depend on making a good choice of a land plot where it will be constructed. There are many characteristics involved descriptions of land available for development. On the one hand, different buildings (with different envisaged use) fit differently to a given location. Residential homes, for example, require a location which will ensure a peaceful lifestyle, with places for walks and recreation, situated in a relatively quite setting. On the other hand, close proximity to schools, shops or a health clinic is another important consideration. Industrial buildings should be localized so as not to be a nuisance to others, and their location should facilitate efficient transport of raw materials and ready products. Yet other requirements are defined for public buildings. It is therefore evident that the characteristics included in an evaluation of the location of a planned building can be highly diverse and their diversity makes the evaluation difficult. Selection of a location can be supported by a variety of methods. For instance, an evaluation can rely on assigning points which indicate the fulfillment of certain criteria. This approach generates a complex evaluation in the form of tables and maps of usefulness. Another possibility is to make an assessment of the criteria that a given land parcels should satisfy in order to develop a specific type of a building. Having combined these two sets of information, we can create a system or a model for the management of land resources, which will easily help to support decision making processes pertaining to the choice of a location. This article shows a model approach for a specific building.

  14. Naturally Efficient Emitters: Luminescent Organometallic Complexes Derived from Natural Products

    Science.gov (United States)

    Zhang, Wen-Hua; Young, David J.

    2013-08-01

    Naturally occurring molecules offer intricate structures and functionality that are the basis of modern medicinal chemistry, but are under-represented in materials science. Herein, we review recent literature describing the use of abundant and relatively inexpensive, natural products for the synthesis of ligands for luminescent organometallic complexes used for organic light emitting diodes (OLEDs) and related technologies. These ligands are prepared from the renewable starting materials caffeine, camphor, pinene and cinchonine and, with the exception of caffeine, impart performance improvements to the emissive metal complexes and resulting OLED devices, with emission wavelengths that span the visible spectrum from blue to red. The advantages of these biologically-derived molecules include improved solution processibility and phase homogeneity, brighter luminescence, higher quantum efficiencies and lower turn-on voltages. While nature has evolved these carbon-skeletons for specific purposes, they also offer some intriguing benefits in materials science and technology.

  15. A Calculus of Located Entities

    Directory of Open Access Journals (Sweden)

    Adriana Compagnoni

    2014-03-01

    Full Text Available We define BioScapeL, a stochastic pi-calculus in 3D-space. A novel aspect of BioScapeL is that entities have programmable locations. The programmer can specify a particular location where to place an entity, or a location relative to the current location of the entity. The motivation for the extension comes from the need to describe the evolution of populations of biochemical species in space, while keeping a sufficiently high level description, so that phenomena like diffusion, collision, and confinement can remain part of the semantics of the calculus. Combined with the random diffusion movement inherited from BioScape, programmable locations allow us to capture the assemblies of configurations of polymers, oligomers, and complexes such as microtubules or actin filaments. Further new aspects of BioScapeL include random translation and scaling. Random translation is instrumental in describing the location of new entities relative to the old ones. For example, when a cell secretes a hydronium ion, the ion should be placed at a given distance from the originating cell, but in a random direction. Additionally, scaling allows us to capture at a high level events such as division and growth; for example, daughter cells after mitosis have half the size of the mother cell.

  16. 14 CFR 21.43 - Location of manufacturing facilities.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Location of manufacturing facilities. 21.43... CERTIFICATION PROCEDURES FOR PRODUCTS AND PARTS Type Certificates § 21.43 Location of manufacturing facilities... location of the manufacturer's facilities places no undue burden on the FAA in administering applicable...

  17. Multi-zone coupling productivity of horizontal well fracturing with complex fracture networks in shale gas reservoirs

    Directory of Open Access Journals (Sweden)

    Weiyao Zhu

    2018-02-01

    Full Text Available In this paper, a series of specific studies were carried out to investigate the complex form of fracture networks and figure out the multi-scale flowing laws of nano/micro pores–complex fracture networks–wellbore during the development of shale reservoirs by means of horizontal well fracturing. First, hydraulic fractures were induced by means of Brazilian splitting tests. Second, the forms of the hydraulic fractures inside the rock samples were observed by means of X-ray CT scanning to measure the opening of hydraulic fractures. Third, based on the multi-scale unified flowing model, morphological description of fractures and gas flowing mechanism in the matrix–complex fracture network–wellbore, the productivity equation of single-stage horizontal well fracturing which includes diffusion, slipping and desorption was established. And fourthly, a productivity prediction model of horizontal well multi-stage fracturing in the shale reservoir was established considering the interference between the multi-stage fracturing zones and the pressure drop in the horizontal wellbore. The following results were obtained. First, hydraulic fractures are in the form of a complex network. Second, the measured opening of hydraulic fractures is in the range of 4.25–453 μm, averaging 112 μm. Third, shale gas flowing in different shapes of fracture networks follows different nonlinear flowing laws. Forth, as the fracture density in the strongly stimulated zones rises and the distribution range of the hydraulic fractures in strongly/weakly stimulated zones enlarges, gas production increases gradually. As the interference occurs in the flowing zones of fracture networks between fractured sections, the increasing amplitude of gas production rates decreases. Fifth, when the length of a simulated horizontal well is 1500 m and the half length of a fracture network in the strongly stimulated zone is 100 m, the productivity effect of stage 10 fracturing is the

  18. A role for human mitochondrial complex II in the production of reactive oxygen species in human skin

    Directory of Open Access Journals (Sweden)

    Alasdair Anderson

    2014-01-01

    Full Text Available The mitochondrial respiratory chain is a major generator of cellular oxidative stress, thought to be an underlying cause of the carcinogenic and ageing process in many tissues including skin. Previous studies of the relative contributions of the respiratory chain (RC complexes I, II and III towards production of reactive oxygen species (ROS have focussed on rat tissues and certainly not on human skin which is surprising as this tissue is regularly exposed to UVA in sunlight, a potent generator of cellular oxidative stress. In a novel approach we have used an array of established specific metabolic inhibitors and DHR123 fluorescence to study the relative roles of the mitochondrial RC complexes in cellular ROS production in 2 types of human skin cells. These include additional enhancement of ROS production by exposure to physiological levels of UVA. The effects within epidermal and dermal derived skin cells are compared to other tissue cell types as well as those harbouring a compromised mitochondrial status (Rho-zero A549. The results show that the complex II inhibitor, TTFA, was the only RC inhibitor to significantly increase UVA-induced ROS production in both skin cell types (P<0.05 suggesting that the role of human skin complex II in terms of influencing ROS production is more important than previously thought particularly in comparison to liver cells. Interestingly, two-fold greater maximal activity of complex II enzyme was observed in both skin cell types compared to liver (P<0.001. The activities of RC enzymes appear to decrease with increasing age and telomere length is correlated with ageing. Our study showed that the level of maximal complex II activity was higher in the MRC5/hTERT (human lung fibroblasts transfected with telomerase cells than the corresponding wild type cells (P=0.0012 which can be considered (in terms of telomerase activity as models of younger and older cells respectively.

  19. Reconfiguring Variety, Profitability, and Postponement for Product Customization with Global Supply Chains

    DEFF Research Database (Denmark)

    Bonev, Martin; Myrodia, Anna; Hvam, Lars

    2016-01-01

    At present, many industrial companies offering high product variety focus on systematically reducing the complexity of their product range and busi-ness processes. Related challenges are often named to increase time to market, reduce the effectiveness in product development, and lower process...... efficiency. For manufacturers with global supply chains additional uncertainties arise in de-fining the right manufacturing strategy with respect to production location and postponement. To better understand related managerial implications, this paper discusses a case study a global manufacturer providing...... customized industrial ap-plications. In particular, the study investigates the relationships between product variant profitability and manufacturing strategy relative to postponement and lo-cation. The results indicate that an improved configuration of these factors through substitution and supply chain...

  20. Enhanced Enzymatic Production of Cephalexin at High Substrate Concentration with in situ Product Removal by Complexation

    Directory of Open Access Journals (Sweden)

    Dengchao Li

    2008-01-01

    Full Text Available Cephalexin (CEX was synthesized with 7-amino-3-deacetoxycephalosporanic acid (7-ADCA and D(–-phenylglycine methyl ester (PGME using immobilized penicillin G acylase from Escherichia coli. It was found that substrate concentration and in situ product could remarkably influence the ratio of synthesis to hydrolysis (S/H and the efficiency of CEX synthesis. The optimal ratio of enzyme to substrate was 65 IU/mM 7-ADCA. High substrate concentration improved the 7-ADCA conversion from 61 to 81 % in the process without in situ product removal (ISPR, while in the synthetic process with ISPR, high substrate concentration increased the 7-ADCA conversion from 88 to 98 %. CEX was easily separated from CEX/β-naphthol complex and its purity and overall yield were 99 and 70 %, respectively.

  1. Disturbance, complexity, and succession of net ecosystem production in North America’s temperate deciduous forests

    Energy Technology Data Exchange (ETDEWEB)

    Gough, Christopher; Curtis, Peter; Hardiman, Brady; Scheuermann, Cynthia; Bond-Lamberty, Benjamin

    2016-06-29

    Century-old forests in the U.S. upper Midwest and Northeast power much of North Amer- ica’s terrestrial carbon (C) sink, but these forests’ production and C sequestration capacity are expected to soon decline as fast-growing early successional species die and are replaced by slower growing late successional species. But will this really happen? Here we marshal empirical data and ecological theory to argue that substantial declines in net ecosystem production (NEP) owing to reduced forest growth, or net primary production (NPP), are not imminent in regrown temperate deciduous forests over the next several decades. Forest age and production data for temperate deciduous forests, synthesized from published literature, suggest slight declines in NEP and increasing or stable NPP during middle successional stages. We revisit long-held hypotheses by EP Odum and others that suggest low-severity, high-frequency disturbances occurring in the region’s aging forests will, against intuition, maintain NEP at higher-than- expected rates by increasing ecosystem complexity, sustaining or enhancing NPP to a level that largely o sets rising C losses as heterotrophic respiration increases. This theoretical model is also supported by biological evidence and observations from the Forest Accelerated Succession Experiment in Michigan, USA. Ecosystems that experience high-severity disturbances that simplify ecosystem complexity can exhibit substantial declines in production during middle stages of succession. However, observations from these ecosystems have exerted a disproportionate in uence on assumptions regarding the trajectory and magnitude of age-related declines in forest production. We conclude that there is a wide ecological space for forests to maintain NPP and, in doing so, lessens the declines in NEP, with signi cant implications for the future of the North American carbon sink. Our intellectual frameworks for understanding forest C cycle dynamics and resilience need to

  2. Sucrose Fermentation by Brazilian Ethanol Production Yeasts in Media Containing Structurally Complex Nitrogen Sources

    OpenAIRE

    Miranda Junior, Messias [UNESP; Batistote, Margareth [UNESP; Cilli, Eduardo Maffud [UNESP; Ernandes, Jose Roberto [UNESP

    2009-01-01

    Four Saccharomyces cerevisiae Brazilian industrial ethanol production strains were grown, under shaken and static conditions, in media containing 22% (w/v) sucrose supplemented with nitrogen sources varying from a single ammonium salt (ammonium sulfate) to free amino acids (casamino acids) and peptides (peptone). Sucrose fermentations by Brazilian industrial ethanol production yeasts strains were strongly affected by both the structural complexity of the nitrogen source and the availability o...

  3. Exploring the dynamic and complex integration of sustainability performance measurement into product development

    DEFF Research Database (Denmark)

    Rodrigues, Vinicius Picanco; Morioka, S.; Pigosso, Daniela Cristina Antelmi

    2016-01-01

    In order to deal with the complex and dynamic nature of sustainability integration into the product development process, this research explore the use of a qualitative System Dynamics approach by using the causal loop diagram (CLD) tool. A literature analysis was followed by a case study, aiming ...

  4. Fuel from Wastewater - Harnessing a Potential Energy Source in Canada through the Co-location of Algae Biofuel Production to Sources of Effluent, Heat and CO2

    Science.gov (United States)

    Klise, G. T.; Roach, J. D.; Passell, H. D.; Moreland, B. D.; O'Leary, S. J.; Pienkos, P. T.; Whalen, J.

    2010-12-01

    Sandia National Laboratories is collaborating with the National Research Council (NRC) Canada and the National Renewable Energy Laboratory (NREL) to develop a decision-support model that will evaluate the tradeoffs associated with high-latitude algae biofuel production co-located with wastewater, CO2, and waste heat. This project helps Canada meet its goal of diversifying fuel sources with algae-based biofuels. The biofuel production will provide a wide range of benefits including wastewater treatment, CO2 reuse and reduction of demand for fossil-based fuels. The higher energy density in algae-based fuels gives them an advantage over crop-based biofuels as the “production” footprint required is much less, resulting in less water consumed and little, if any conversion of agricultural land from food to fuel production. Besides being a potential source for liquid fuel, algae have the potential to be used to generate electricity through the burning of dried biomass, or anaerobically digested to generate methane for electricity production. Co-locating algae production with waste streams may be crucial for making algae an economically valuable fuel source, and will certainly improve its overall ecological sustainability. The modeling process will address these questions, and others that are important to the use of water for energy production: What are the locations where all resources are co-located, and what volumes of algal biomass and oil can be produced there? In locations where co-location does not occur, what resources should be transported, and how far, while maintaining economic viability? This work is being funded through the U.S. Department of Energy (DOE) Biomass Program Office of Energy Efficiency and Renewable Energy, and is part of a larger collaborative effort that includes sampling, strain isolation, strain characterization and cultivation being performed by the NREL and Canada’s NRC. Results from the NREL / NRC collaboration including specific

  5. [Environmental pollution by products of wear and tear automobile-road complex].

    Science.gov (United States)

    Levanchuk, A V

    2014-01-01

    North-West State Medical University named after I.I. Mechnikov, Saint Petersburg, Russian Federation, 191015. There is supposed the method for the assessment of amounts of pollutants released into the environment during the operational wear of tyre treads, brake system of cars and the road pavement. There are presented results of chemical analysis of residues of combustion. The necessity of control of products of work wear of automobile-road complex has been substantiated.

  6. THE MARKETING MIX AND THE COMPLEX PACKAGES OF PRODUCTS AND SERVICES

    Directory of Open Access Journals (Sweden)

    Adina Claudia NEAMŢU

    2010-12-01

    Full Text Available From its appearance until now, marketing has been approached under diverse aspects, from market theories to constituent elements, all being based on the four elements of the marketing mix: product, price, placement and promotion, developing around them specific policies, the inner correlations, investigation methods and techniques, experimental texts and motivation studies. The development of products with special characteristics, highly specialized, but also the ever growing competition between producers and sellers, the more diversified and elaborate options of customers, wanting to satisfy superior needs, like recognition, social status and esteem, safety, appreciation, all lead to the apparition and commercialization of complex product and service packages.48 These cannot be analyzed and reflected in the scientific literature with just the classic elements of the marketing mix. To these, we can add the process, people, tightly linked to the process and the physical evidence, or place where the personnel interacts with the customers.

  7. Fabrication of Complex Optical Components From Mold Design to Product

    CERN Document Server

    Riemer, Oltmann; Gläbe, Ralf

    2013-01-01

    High quality optical components for consumer products made of glass and plastic are mostly fabricated by replication. This highly developed production technology requires several consecutive, well-matched processing steps called a "process chain" covering all steps from mold design, advanced machining and coating of molds, up to the actual replication and final precision measurement of the quality of the optical components. Current market demands for leading edge optical applications require high precision and cost effective parts in large volumes. For meeting these demands it is necessary to develop high quality process chains and moreover, to crosslink all demands and interdependencies within these process chains. The Transregional Collaborative Research Center "Process chains for the replication of complex optical elements" at Bremen, Aachen and Stillwater worked extensively and thoroughly in this field from 2001 to 2012. This volume will present the latest scientific results for the complete process chain...

  8. Infrastructure and industrial location : a dual technology approach

    OpenAIRE

    Bjorvatn, Kjetil

    2001-01-01

    The paper investigates how differences in infrastructure quality may affect industrial location between countries. Employing a dualtechnology model, the main result of the paper is the somewhat surprising conclusion that an improvement in a country’s infrastructure may weaken its locational advantage and induce a firm to locate production in a country with a less efficient infrastructure.

  9. Location and regional productive specialization in Colombia

    Directory of Open Access Journals (Sweden)

    Henry Antonio Mendoza Tolosa

    2017-03-01

    Full Text Available This document is directed to responding if Colombian regional economies restructured their productive activities from 2000 to 2014, and if so, illustrate the way that process has been effective in the different departments from the results and dynamics of their economic activities. For developing this exercise, we used a set of statistical indicators of spatial geography, among which is the factorial analysis, specifically the method of principal components, whose purpose was to identify the set activities whose performance explains more clearly the productive orientation of the departments, and complementary synthetic regional specialization indexes were employed in order to identify the degree and the changes of economic diversification, presented in those indicators. The results of this research shows that most of the Colombian regions have diversified their economic activity, with focus on service activities, among which are representative government and non-market services produced by those institutions, nowadays less dependent on few sources of growth. However, in other regions the primary sector, mainly mining activity, for many years has been the most important activity of production structures, affecting the process of full diversification, which is close to current local demands and international economic order the requests with greater intensity.

  10. Preliminary safety analysis of a PBMR supplying process heat to a co-located ethylene production plant

    International Nuclear Information System (INIS)

    Scarlat, Raluca O.; Cisneros, Anselmo T.; Koutchesfahani, Tawni; Hong, Rada; Peterson, Per F.

    2012-01-01

    This paper considers the safety analysis and licensing approach for co-locating a pebble bed modular reactor (PBMR) to provide process heat to an ethylene production unit. The PBMR is an advanced nuclear reactor design that provides 400 MW of thermal energy. Ethylene production is an energy intensive process that utilizes large gas furnaces to provide the heat for the process. Coupling a PBMR with an ethylene production plant would open a new market for nuclear power, and would provide the chemical industry with a cleaner power source, helping to achieve the Clean Air Act standards, and eliminating the 0.5 ton of CO 2 emissions per ton of produced ethylene. Our analysis uses the Chevron Phillips chemical plant in Sweeney, TX as a prototypical site. The plant has four ethylene production trains, with a total power consumption of 2.4 GW, for an ethylene output of 3.7 million tons per year, 4% of the global ethylene production capacity. This paper proposes replacement of the gas furnaces by low-emission PBMR modules, and presents the safety concerns and risk mitigation and management options for this coupled system. Two coupling design options are proposed, and the necessary changes to the design basis events and severe accidents for the PBMR licensing application are discussed. A joint effort between the chemical and the nuclear entities to optimize the coupling design, establish preventive maintenance procedures, and develop emergency response plans for both of the units is recommended.

  11. Preliminary safety analysis of a PBMR supplying process heat to a co-located ethylene production plant

    Energy Technology Data Exchange (ETDEWEB)

    Scarlat, Raluca O., E-mail: rscarlat@nuc.berkeley.edu [University of California Berkeley, Nuclear Engineering, 4118 Etcheverry Hall, Berkeley, CA 94720 (United States); Cisneros, Anselmo T. [University of California Berkeley, Nuclear Engineering, 4118 Etcheverry Hall, Berkeley, CA 94720 (United States); Koutchesfahani, Tawni [University of California, Chemical and Biomolecular Engineering, 201 Gilman Hall, Berkeley, CA 94720 (United States); Hong, Rada; Peterson, Per F. [University of California Berkeley, Nuclear Engineering, 4118 Etcheverry Hall, Berkeley, CA 94720 (United States)

    2012-10-15

    This paper considers the safety analysis and licensing approach for co-locating a pebble bed modular reactor (PBMR) to provide process heat to an ethylene production unit. The PBMR is an advanced nuclear reactor design that provides 400 MW of thermal energy. Ethylene production is an energy intensive process that utilizes large gas furnaces to provide the heat for the process. Coupling a PBMR with an ethylene production plant would open a new market for nuclear power, and would provide the chemical industry with a cleaner power source, helping to achieve the Clean Air Act standards, and eliminating the 0.5 ton of CO{sub 2} emissions per ton of produced ethylene. Our analysis uses the Chevron Phillips chemical plant in Sweeney, TX as a prototypical site. The plant has four ethylene production trains, with a total power consumption of 2.4 GW, for an ethylene output of 3.7 million tons per year, 4% of the global ethylene production capacity. This paper proposes replacement of the gas furnaces by low-emission PBMR modules, and presents the safety concerns and risk mitigation and management options for this coupled system. Two coupling design options are proposed, and the necessary changes to the design basis events and severe accidents for the PBMR licensing application are discussed. A joint effort between the chemical and the nuclear entities to optimize the coupling design, establish preventive maintenance procedures, and develop emergency response plans for both of the units is recommended.

  12. COMPLEX PROCESSING OF CELLULOSE WASTE FROM POULTRY AND SUGAR PRODUCTION

    Directory of Open Access Journals (Sweden)

    E. V. Sklyadnev

    2015-01-01

    Full Text Available Summary.To solve the problem of disposing of huge volumes of cellulose waste from sugar production in the form of beet pulp and waste of poultry farms in the form of poultry manure is proposed to use the joint use of two methods of thermal processing of waste - pyrolysis and gasification. The possibility of using pyrolysis applied to the waste are confirmed by experimental results. Based on the results of laboratory studies of the properties of by-products resulting from the thermal processing of the feedstock, it is proposed complex processing to produce useful products, to be implemented in the form of marketable products, and the organization's own process energy utilization. Developed flow diagram of an integrated processing said waste comprises 3 sections, which successively carried out: pyrolytic decomposition of the feedstock to obtain a secondary product in the form of solid, liquid and gas fractions, the gasification of solids to obtain combustible gas and separating the liquid fraction by distillation to obtain valuable products. The main equipment in the first region is the pyrolysis reactor cascade condensers; the second section - gasifiers layers and stream type; the third - one or more distillation columns with the necessary strapping. Proper power supply installation is organized by the use of the heat produced during combustion of the synthesis gas for heating and gasification reactor. For the developed scheme presents calculations of the heat balance of the installation, supporting the energy efficiency of the proposed disposal process. Developments carried out in the framework of the project the winner of the Youth Prize Competition Government of Voronezh region to support youth programs in the 2014-2015.

  13. Spatial products available for identifying areas of likely wildfire ignitions using lightning location data-Wildland Fire Assessment System (WFAS)

    Science.gov (United States)

    Paul Sopko; Larry Bradshaw; Matt Jolly

    2016-01-01

    The Wildland Fire Assessment System (WFAS, www.wfas.net) is a one-stop-shop giving wildland fire managers the ability to assess fire potential ranging in scale from national to regional and temporally from 1 to 5 days. Each day, broad-area maps are produced from fire weather station and lightning location networks. Three products are created using 24 hour...

  14. Profiling high-frequency accident locations using association rules

    OpenAIRE

    GEURTS, Karolien; WETS, Geert; BRIJS, Tom; VANHOOF, Koen

    2003-01-01

    In Belgium, traffic safety is currently one of the government's highest priorities. Identifying and profiling black spots and black zones in terms of accident related data and location characteristics must provide new insights into the complexity and causes of road accidents, which, in ram, provide valuable input for government actions. In this paper, association rules are used to identify accident circumstances that frequently occur together at high frequency accident locations. Furthermore...

  15. Identification of the Mitochondrial Heme Metabolism Complex.

    Science.gov (United States)

    Medlock, Amy E; Shiferaw, Mesafint T; Marcero, Jason R; Vashisht, Ajay A; Wohlschlegel, James A; Phillips, John D; Dailey, Harry A

    2015-01-01

    Heme is an essential cofactor for most organisms and all metazoans. While the individual enzymes involved in synthesis and utilization of heme are fairly well known, less is known about the intracellular trafficking of porphyrins and heme, or regulation of heme biosynthesis via protein complexes. To better understand this process we have undertaken a study of macromolecular assemblies associated with heme synthesis. Herein we have utilized mass spectrometry with coimmunoprecipitation of tagged enzymes of the heme biosynthetic pathway in a developing erythroid cell culture model to identify putative protein partners. The validity of these data obtained in the tagged protein system is confirmed by normal porphyrin/heme production by the engineered cells. Data obtained are consistent with the presence of a mitochondrial heme metabolism complex which minimally consists of ferrochelatase, protoporphyrinogen oxidase and aminolevulinic acid synthase-2. Additional proteins involved in iron and intermediary metabolism as well as mitochondrial transporters were identified as potential partners in this complex. The data are consistent with the known location of protein components and support a model of transient protein-protein interactions within a dynamic protein complex.

  16. THE MODERN THEORY AND TECHNOLOGY OF PRODUCTION, PROCESSING AND USE OF THE PRODUCTS OF COMPLEX PROCESSING OF WHEAT GERM

    Directory of Open Access Journals (Sweden)

    N. S. Rodionova

    2014-01-01

    Full Text Available Summary. The data and methods for the preparation of deep processing of wheat germ and their impact on the physical and chemical properties of the final products. It was found that for use in food technology is preferable to use a method is-cold-pressed wheat germ, under which the processed products do not present a residual amount of solvents and other non-food components. Given food and biological characteristics of wheat germ and products deep processing, it was found that they contain vitamin E, A, D, vitamin group В, more than 20 macro- and microelements. Methods of extracting oil from different types raw materials. Analyzed the functional role of ω-6 and ω -3 fatty acids for the human body and ways to maintain balance. A review of plant oils, the prospects of its use to create food systems balanced composition of fatty acids. It was found that the ratio of ω-6 and ω -3 fatty acids in wheat germ oil does not meet the recommended therefore to establish the necessary balance it is preferable to mix amaranth oil and pumpkin. Classified the factors affecting the quality parameters of wheat germ stored, evaluated the role of the enzyme complex during storage of wheat germ and their products deep processing. It was found that a significant effect on the damage of wheat germ has a dual action of lipase, lipoxygenase and catalase. Given the storage and stabilization of wheat germ, shows the potential use of stabilizers to increase the shelf life of wheat germ. As stabilizers, preference is given to compositions of organic acids: ascorbic, succinic and fumaric. It is proved that the composition of organic acids suppress the activity of lipase and lipoxygenase catalase by wheatgerm type noncompetitive inhibition. A review of the technologies used wheat germ and products of their complex processing in medical, cosmetic, feed and food industry. Evaluated the potential application of wheat germ and products deep processing industry of functional

  17. San Rafael mining and fabrication complex today

    International Nuclear Information System (INIS)

    Navarra, Pablo; Aldebert, Sergio R.

    2005-01-01

    In Mendoza province, 35 km West San Rafael city, is located a CNEA installation for uranium ore extraction and concentration: the San Rafael Mining and Fabrication Complex. By the middle of the nineties, as a consequence of the very low prices of uranium concentrate in the international market and of the high internal production costs, uranium extraction was stopped. To day, the international price of the concentrate had a very important increase and the Government has decided the completion of the Atucha II Nuclear Power Station construction. Moreover, studies have been started for new nuclear power plants. In such circumstances the reactivation of the Complex will make sure the uranium supply for our nuclear power stations, contributing to the improvement of the energy generation mix in our country. (author) [es

  18. The role of compound nuclei and deep-inelastic scattering in complex fragment production at intermediate energies

    International Nuclear Information System (INIS)

    Wozniak, G.J.; Colonna, N.; Charity, R.J.; Moretto, L.G.

    1989-02-01

    The dependence of complex fragment production on the asymmetry of the entrance channel has been investigated with the 18 A MeV 139 La + 12 C, 27 Al, 64 Ni reactions. Invariant cross section plots show a very simple pattern for the two lighter targets and a more complex one for the heavier 64 Ni target. The observed complex fragments are shown to result from quasi-elastic/deep-inelastic reactions and from compound nuclei formed in complete/incomplete fusion processes. 9 refs., 10 figs

  19. New complex fertilizer 'Suprodit' to obtain safe agricultural productions on contaminated lands.

    Science.gov (United States)

    Nikolaevich Ratnikov, Alexander; Sergeevich Anisimov, Vyacheslav; Nikoaevna Anisimova, Lidiya; Georgievich Sviridenko, Dmitry; Jurievna Balanova, Olesya

    2015-04-01

    One of the reclamation techniques to reduce the accumulation of radionuclides and heavy metals in the crop is the use of natural sorbents, industrial deposits of which are located in the contaminated areas or at distances that allows one to organize cheap their delivery to the application site. More promising reclamation technique is the use of new types of complex fertilizers, the main components of which are special sorbents of natural or artificial origin. New complex fertilizer of prolonged action - "SUPRODIT", containing in addition to nutrients highly efficient mineral and organic sorbents, was developed by specialists of the RIRAE. The feedstock for mineral sorbent was Tripoli (finely porous siliceous mineral) from local field (Kaluga region), organic sorbent - peat. The "SUPRODIT"composition: N - 8-11%; P2O5 - 11-13 %; K2O - 11-17%, organic matter and 30-40%, respectively. The effect of a single application of complex fertilizer will be maintained for two or more growing seasons. Received RF patent for the invention "Method of production of complex fertilizer of prolonged action". In a series of field experiments on sod-podzolic sandy loam soil it was shown that the application of "SUPRODIT" at dose of 800 kg/ha to soil contaminated with dehydrated sewage sludge (DSS), significantly reduces heavy metals (Cd, Ni, Pb) content in a crop of oats and barley due to the sorption properties of this fertilizers. Thus, Cd accumulation in the oats grain decreased 1.3 times, barley grain - 1.5 times, Ni - 1.5 times for barley and oats; Pb - 1.8 and 1.7 times respectively opposite to variant where the DSS was applied only. "SUPRODIT" reduces the negative effects of HM on the growth and development of plants, and limits the accumulation of 137Cs and HM in biomass. The 137Cs content in the biomass of barley in the variant of jointly added to soil of 137Cs and "SUPRODIT" decreased by 8.9 times in comparison with control and 4.4 times compared with standard fertilizers (NPK

  20. Variations in the radiation sensitivity of foodborne pathogens associated with complex ready-to-eat food products

    Science.gov (United States)

    Sommers, Christopher H.; Boyd, Glenn

    2006-07-01

    Foodborne illness outbreaks and product recalls are occasionally associated with ready-to-eat (RTE) sandwiches and other "heat and eat" multi-component RTE products. Ionizing radiation can inactivate foodborne pathogens on meat and poultry, fruits and vegetables, seafood, and RTE meat products. However, less data are available on the ability of low-dose ionizing radiation, doses under 5 kGy typically used for pasteurization purposes, to inactivate pathogenic bacteria on complex multi-component food products. In this study, the efficacy of ionizing radiation to inactivate Salmonella spp., Listeria monocytogenes, Staphylococcus aureus, Escherichia coli O157:H7, and Yersinia enterocolitica on RTE foods including a "frankfurter on a roll", a "beef cheeseburger on a bun" and a "vegetarian cheeseburger on a bun" was investigated. The average D-10 values, the radiation dose needed to inactivate 1 log 10 of pathogen, by bacterium species, were 0.61, 0.54, 0.47, 0.36 and 0.15 kGy for Salmonella spp., S. aureus, L. monocytogenes, E. coli O157:H7, and Y. enterocolitica, respectively when inoculated onto the three product types. These results indicate that irradiation may be an effective means for inactivating common foodborne pathogens including Salmonella spp, S. aureus, L. monocytogenes, E. coli O157:H7 and Y. enterocolitica in complex RTE food products such as 'heat and eat" sandwich products.

  1. Variations in the radiation sensitivity of foodborne pathogens associated with complex ready-to-eat food products

    International Nuclear Information System (INIS)

    Sommers, Christopher H.; Boyd, Glenn

    2006-01-01

    Foodborne illness outbreaks and product recalls are occasionally associated with ready-to-eat (RTE) sandwiches and other 'heat and eat' multi-component RTE products. Ionizing radiation can inactivate foodborne pathogens on meat and poultry, fruits and vegetables, seafood, and RTE meat products. However, less data are available on the ability of low-dose ionizing radiation, doses under 5 kGy typically used for pasteurization purposes, to inactivate pathogenic bacteria on complex multi-component food products. In this study, the efficacy of ionizing radiation to inactivate Salmonella spp., Listeria monocytogenes, Staphylococcus aureus, Escherichia coli O157:H7, and Yersinia enterocolitica on RTE foods including a 'frankfurter on a roll', a 'beef cheeseburger on a bun' and a 'vegetarian cheeseburger on a bun' was investigated. The average D-10 values, the radiation dose needed to inactivate 1 log 1 of pathogen, by bacterium species, were 0.61, 0.54, 0.47, 0.36 and 0.15 kGy for Salmonella spp., S. aureus, L. monocytogenes, E. coli O157:H7, and Y. enterocolitica, respectively when inoculated onto the three product types. These results indicate that irradiation may be an effective means for inactivating common foodborne pathogens including Salmonella spp, S. aureus, L. monocytogenes, E. coli O157:H7 and Y. enterocolitica in complex RTE food products such as 'heat and eat' sandwich products

  2. A Spatial Decision Support System Framework for the Evaluation of Biomass Energy Production Locations: Case Study in the Regional Unit of Drama, Greece

    Directory of Open Access Journals (Sweden)

    Konstantinos Ioannou

    2018-02-01

    Full Text Available Renewable Energy Sources are expected to play a very important role in energy production in the following years. They constitute an energy production methodology which, if properly enabled, can ensure energy sufficiency as well as the protection of the environment. Energy production from biomass in particular is a very common method, which exploits a variety of resources (wood and wood waste, agricultural crops and their by-products after cultivation, animal wastes, Municipal Solid Waste (MSW and food processing wastes for the production of energy. This paper presents a Spatial Decision Support System, which enables managers to locate the most suitable areas for biomass power plant installation. For doing this, fuzzy logic and fuzzy membership functions are used for the creation of criteria layers and suitability maps. In this paper, we use a Multicriteria Decision Analysis methodology (Analytical Hierarchy Process combined with fuzzy system elements for the determination of the weight coefficients of the participating criteria. Then, based on the combination of fuzzy logic and theAnalytic Hierarchy Process (AHP, a final proposal is created thatdivides the area into four categories regarding their suitability forsupporting a biomass energy production power plant. For the two optimal locations, the biomass is also calculated.The framework is applied to theRegional Unit of Drama, which is situated in Northern Greece and is very well known for the area’s forest and agricultural production.

  3. Axiomatic design in large systems complex products, buildings and manufacturing systems

    CERN Document Server

    Suh, Nam

    2016-01-01

    This book provides a synthesis of recent developments in Axiomatic Design theory and its application in large complex systems. Introductory chapters provide concise tutorial materials for graduate students and new practitioners, presenting the fundamentals of Axiomatic Design and relating its key concepts to those of model-based systems engineering. A mathematical exposition of design axioms is also provided. The main body of the book, which represents a concentrated treatment of several applications, is divided into three parts covering work on: complex products; buildings; and manufacturing systems. The book shows how design work in these areas can benefit from the scientific and systematic underpinning provided by Axiomatic Design, and in so doing effectively combines the state of the art in design research with practice. All contributions were written by an international group of leading proponents of Axiomatic Design. The book concludes with a call to action motivating further research into the engineeri...

  4. Power technology complex for production of motor fuel from brown coals with power supply from NPPs

    International Nuclear Information System (INIS)

    Troyanov, M.F.; Poplavskij, V.M.; Sidorov, G.I.; Bondarenko, A.V.; Chebeskov, A.N.; Chushkin, V.N.; Karabash, A.A.; Krichko, A.A.; Maloletnev, A.S.

    1998-01-01

    With the present-day challenge of efficient use of low-grade coals and current restructuring of coal industry in the Russian Federation, it is urgent to organise the motor fuel production by the synthesis from low grade coals and heavy petroleum residues. With this objective in view, the Institute of Physics and Power Engineering of RF Minatom and Combustible Resources Institute of RF Mintopenergo proposed a project of a standard nuclear power technology complex for synthetic liquid fuel (SLF) production using fast neutron reactors for power supply. The proposed project has two main objectives: (1) Engineering and economical optimization of the nuclear power supply for SLF production; and (2) Engineering and economical optimization of the SLF production by hydrogenisation of brown coals and heavy petroleum residues with a complex development of advanced coal chemistry. As a first approach, a scheme is proposed with the use of existing reactor cooling equipment, in particular, steam generators of BN-600, limiting the effect on safety of reactor facility operation at minimum in case of deviations and abnormalities in the operation of technological complex. The possibility to exclude additional requirements to the equipment for nuclear facility cooling was also taken into account. It was proposed to use an intermediate steam-water circuit between the secondary circuit sodium and the coolant to heat the technological equipment. The only change required for the BN-600 equipment will be the replacement of sections of intermediate steam superheaters at the section of main steam superheaters. The economic aspects of synthetic motor fuel production proposed by the joint project depend on the evaluation of integral balances: thermal power engineering, chemical technology, the development of advanced large scale coal chemistry of high profitability; utilisation of ash and precious microelements in waste-free technology; production of valuable isotopes; radical solution of

  5. Dynamic Roles and Locations of Manufacturing

    DEFF Research Database (Denmark)

    Slepniov, Dmitrij; Wæhrens, Brian Vejrum; Johansen, John

    2014-01-01

    Purpose – The principal objective of this paper is to relate functional nodes of production and innovation in global operations networks. The authors aim to capture the implications of changing strategic roles and locations of manufacturing for innovation capabilities. Design...... companies presented in this paper, the authors find that although the potential benefits of global dispersion of manufacturing are vast, the realisation of these potentials depends on how successful companies are with linking the new strategic roles and locations of manufacturing with innovation...... of global dispersion of operations. The findings assist global companies in organising cross-functional coordination and interrelated functional nodes of production and innovation in global operations networks. Originality/value – Not only routine transactional tasks but also more knowledge...

  6. Quantitative analytical hierarchy process to marketing store location selection

    OpenAIRE

    Harwati; Utami Intan

    2018-01-01

    The selection of Store to market the product is belong to Multi Criteria Decision Making problem. The criteria used have conflict of interest with each other to produce an optimal location. This research uses four important criteria to select new location of marketing store appropriate with the references: distance to location, competition level with competitor, number of potential customer, and location rent cost. Quantitative data is used to determine the optimum location with AHP method. Q...

  7. Profiling high frequency accident locations using associations rules

    OpenAIRE

    GEURTS, Karolien; WETS, Geert; BRIJS, Tom; VANHOOF, Koen

    2002-01-01

    In Belgium, traffic safety is currently one of the government’s highest priorities. Identifying and profiling black spots and black zones in terms of accident related data and location characteristics must provide new insights into the complexity and causes of road accidents which, in turn, provide valuable input for government actions. In this paper, association rules are used to identify accident circumstances that frequently occur together at high frequency accident locations. Furthermore,...

  8. Production Scheduling in Complex Job Shops from an Industrie 4.0 Perspective: A Review and Challenges in the Semiconductor Industry

    OpenAIRE

    Waschneck, Bernd; Bauernhansl, Thomas; Altenmüller, Thomas; Kyek, Andreas

    2017-01-01

    On the one hand, Industrie 4.0 has recently emerged as the keyword for increasing productivity in the 21st century. On the other hand, production scheduling in a Complex Job Shop (CJS) environment, such as wafer fabrication facilities, has drawn interest of researchers dating back to the 1950s [65, 18]. Although both research areas overlap, there seems to be very little interchange of ideas. This review presents and assesses production scheduling techniques in complex job shops from an Indust...

  9. Influence of the vibration source location on the modes of jet disintegration in the priller and on monodispersity of the finished product

    OpenAIRE

    Skydanenko, Maksym; Kononenko, Mykola; Kurdes, Yuliia

    2017-01-01

    Influence of the vibration source location on the modes of liquid jets disintegration and obtaining monodisperse droplets and granules of the finished product is theoretically grounded and experimentally confirmed. The experiment was conducted on an experimental stand of industrial granulation equipment.

  10. A Lean Framework for Production Control in Complex and Constrained Construction Projects (PC4P)

    DEFF Research Database (Denmark)

    Lindhard, Søren Munch; Wandahl, Søren

    2014-01-01

    Production conditions in construction are different than in themanufacturing industry. First of all, construction is rooted in place and conducted as on-site manufacturing. Secondly, every construction project is unique and a one-of-a-kind production, managed by a temporary organization consisting...... and constrained construction project. Even though several tools have attempted to add structure and to create order, to the complex, dynamic, and uncertain context in which constructions is conducted, none has yet fully succeeded in providing a robust production control system. With outset in the lean tool Last...

  11. Beneficiation of Stillwater Complex Rock for the Production of Lunar Simulants

    Science.gov (United States)

    Rickman, D. L.; Young, C.; Stoeser, D.; Edmunson, J.

    2014-01-01

    The availability of pure, high calcium plagioclase would be a significant asset in any attempt to manufacture high-quality lunar simulants. A suitable plagioclase product can be obtained from materials obtained from the Stillwater Complex of Montana. The access, geology, petrology, and mineralogy of the relevant rocks and the mill tailings are described here. This study demonstrates successful plagioclase recovery from mill tailings produced by the Stillwater Mine Company. Hydrogen peroxide was used to remove carboxymethyl cellulose from the tailing. The characteristics of the plagioclase products are shown and locked grains are identified as a limit to achievable purity. Based on the experimental results, flowsheets were developed showing how these resources could be processed and made into 'separates' of (1) high calcium plagioclase and (2) orthopyroxene/clinopyroxene with the thought that they would be combined later to make simulant.

  12. Semantic Location Extraction from Crowdsourced Data

    Science.gov (United States)

    Koswatte, S.; Mcdougall, K.; Liu, X.

    2016-06-01

    Crowdsourced Data (CSD) has recently received increased attention in many application areas including disaster management. Convenience of production and use, data currency and abundancy are some of the key reasons for attracting this high interest. Conversely, quality issues like incompleteness, credibility and relevancy prevent the direct use of such data in important applications like disaster management. Moreover, location information availability of CSD is problematic as it remains very low in many crowd sourced platforms such as Twitter. Also, this recorded location is mostly related to the mobile device or user location and often does not represent the event location. In CSD, event location is discussed descriptively in the comments in addition to the recorded location (which is generated by means of mobile device's GPS or mobile communication network). This study attempts to semantically extract the CSD location information with the help of an ontological Gazetteer and other available resources. 2011 Queensland flood tweets and Ushahidi Crowd Map data were semantically analysed to extract the location information with the support of Queensland Gazetteer which is converted to an ontological gazetteer and a global gazetteer. Some preliminary results show that the use of ontologies and semantics can improve the accuracy of place name identification of CSD and the process of location information extraction.

  13. SEMANTIC LOCATION EXTRACTION FROM CROWDSOURCED DATA

    Directory of Open Access Journals (Sweden)

    S. Koswatte

    2016-06-01

    Full Text Available Crowdsourced Data (CSD has recently received increased attention in many application areas including disaster management. Convenience of production and use, data currency and abundancy are some of the key reasons for attracting this high interest. Conversely, quality issues like incompleteness, credibility and relevancy prevent the direct use of such data in important applications like disaster management. Moreover, location information availability of CSD is problematic as it remains very low in many crowd sourced platforms such as Twitter. Also, this recorded location is mostly related to the mobile device or user location and often does not represent the event location. In CSD, event location is discussed descriptively in the comments in addition to the recorded location (which is generated by means of mobile device's GPS or mobile communication network. This study attempts to semantically extract the CSD location information with the help of an ontological Gazetteer and other available resources. 2011 Queensland flood tweets and Ushahidi Crowd Map data were semantically analysed to extract the location information with the support of Queensland Gazetteer which is converted to an ontological gazetteer and a global gazetteer. Some preliminary results show that the use of ontologies and semantics can improve the accuracy of place name identification of CSD and the process of location information extraction.

  14. A Ricardian model of new trade and location theory

    OpenAIRE

    Ricci, Luca Antonio

    1996-01-01

    This paper provides a new model of firm's location choices. It integrates a Ricardian model of comparative advantage with the location effects deriving from trade costs, increasing returns to scale, product differentiation, and monopolistic competition. In a two-region, two-differentiated-good, one-factor framework, the regional degree of specialization depends positively on the extent of the comparative advantage in productivity and on the degree of returns to scale; it depends negatively on...

  15. Phenomenology of on-shell Higgs production in the MSSM with complex parameters

    Energy Technology Data Exchange (ETDEWEB)

    Liebler, Stefan; Patel, Shruti; Weiglein, Georg

    2016-11-15

    A computation of inclusive cross sections for the production of neutral Higgs bosons through gluon fusion and bottom-quark annihilation is presented in the MSSM with complex parameters. The predictions for the gluon-fusion process are based on an explicit calculation of the leading-order cross section for the general case of arbitrary complex parameters which is supplemented by higher-order corrections. Massive top- and bottom-quark contributions are included at NLO QCD. In the effective theory of a heavy top-quark the top-quark contribution is taken into account up to N{sup 3}LO QCD in an expansion around the threshold of Higgs production for the CP-even component of the light Higgs boson. For the CP-odd component of the light Higgs boson and the heavy Higgs bosons the contributions in the effective field theory are incorporated up to NNLO QCD. Two-loop electroweak effects mediated through light quarks are also incorporated, and SUSY QCD corrections at NLO are interpolated from the MSSM with real parameters. Finite wave function normalisation factors for the external Higgs bosons ensuring the correct on-shell properties are incorporated from the code FeynHiggs. In the numerical analysis for the typical case of a strong admixture of the two heavy Higgs bosons it is demonstrated that squark effects are strongly dependent on the phases of the complex parameters, and the relevance of the resummation of squark effects in the bottom-quark Yukawa coupling is emphasised. The remaining theoretical uncertainties in the cross section predictions are discussed. The results have been implemented into an extension of the numerical code SusHi called SusHiMi.

  16. Phenomenology of on-shell Higgs production in the MSSM with complex parameters

    International Nuclear Information System (INIS)

    Liebler, Stefan; Patel, Shruti; Weiglein, Georg

    2016-11-01

    A computation of inclusive cross sections for the production of neutral Higgs bosons through gluon fusion and bottom-quark annihilation is presented in the MSSM with complex parameters. The predictions for the gluon-fusion process are based on an explicit calculation of the leading-order cross section for the general case of arbitrary complex parameters which is supplemented by higher-order corrections. Massive top- and bottom-quark contributions are included at NLO QCD. In the effective theory of a heavy top-quark the top-quark contribution is taken into account up to N"3LO QCD in an expansion around the threshold of Higgs production for the CP-even component of the light Higgs boson. For the CP-odd component of the light Higgs boson and the heavy Higgs bosons the contributions in the effective field theory are incorporated up to NNLO QCD. Two-loop electroweak effects mediated through light quarks are also incorporated, and SUSY QCD corrections at NLO are interpolated from the MSSM with real parameters. Finite wave function normalisation factors for the external Higgs bosons ensuring the correct on-shell properties are incorporated from the code FeynHiggs. In the numerical analysis for the typical case of a strong admixture of the two heavy Higgs bosons it is demonstrated that squark effects are strongly dependent on the phases of the complex parameters, and the relevance of the resummation of squark effects in the bottom-quark Yukawa coupling is emphasised. The remaining theoretical uncertainties in the cross section predictions are discussed. The results have been implemented into an extension of the numerical code SusHi called SusHiMi.

  17. Locating one pairwise interaction: Three recursive constructions

    Directory of Open Access Journals (Sweden)

    Charles J. Colbourn

    2016-09-01

    Full Text Available In a complex component-based system, choices (levels for components (factors may interact tocause faults in the system behaviour. When faults may be caused by interactions among few factorsat specific levels, covering arrays provide a combinatorial test suite for discovering the presence offaults. While well studied, covering arrays do not enable one to determine the specific levels of factorscausing the faults; locating arrays ensure that the results from test suite execution suffice to determinethe precise levels and factors causing faults, when the number of such causes is small. Constructionsfor locating arrays are at present limited to heuristic computational methods and quite specific directconstructions. In this paper three recursive constructions are developed for locating arrays to locateone pairwise interaction causing a fault.

  18. Optimization of production in the oil field through the study of the problem of location of wells and production units; Otimizacao da producao em campo de petroleo pelo estudo do problema de localizacao de pocos e unidades de producao

    Energy Technology Data Exchange (ETDEWEB)

    Santana, Roberta G.S. [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil); Rosa, Vinicius R. [Petroleo Brasileiro S.A. (PETROBRAS), Rio de Janeiro, RJ (Brazil)

    2012-07-01

    This project provides a process for determining the best location of well and production units in an oil field in order to optimize the reservoir performance and the volume of recovered oil, maximizing the profitability. The process uses various statistical analyses presented in the reservoir simulation results, under considerations and parameters. Sensibility analysis and response surface methodology is also applied to a better understanding of how each well influence the total production and the location of the platform and/or manifold can be changed to optimize the production. The method is shown being applied on a field scale with synthetic data. It aims to be a new way of guiding decision-making on a project to develop a field production. (author)

  19. Variations in the radiation sensitivity of foodborne pathogens associated with complex ready-to-eat food products

    Energy Technology Data Exchange (ETDEWEB)

    Sommers, Christopher H. [Food Safety Intervention Technologies Research Unit, Eastern Regional Research Center, Agricultural Research Service, US Department of Agriculture, 600 East Mermaid Lane, Wyndmoor, PA 19038 (United States)]. E-mail: csommers@errc.ars.usda.gov; Boyd, Glenn [Food Safety Intervention Technologies Research Unit, Eastern Regional Research Center, Agricultural Research Service, US Department of Agriculture, 600 East Mermaid Lane, Wyndmoor, PA 19038 (United States)

    2006-07-15

    Foodborne illness outbreaks and product recalls are occasionally associated with ready-to-eat (RTE) sandwiches and other 'heat and eat' multi-component RTE products. Ionizing radiation can inactivate foodborne pathogens on meat and poultry, fruits and vegetables, seafood, and RTE meat products. However, less data are available on the ability of low-dose ionizing radiation, doses under 5 kGy typically used for pasteurization purposes, to inactivate pathogenic bacteria on complex multi-component food products. In this study, the efficacy of ionizing radiation to inactivate Salmonella spp., Listeria monocytogenes, Staphylococcus aureus, Escherichia coli O157:H7, and Yersinia enterocolitica on RTE foods including a 'frankfurter on a roll', a 'beef cheeseburger on a bun' and a 'vegetarian cheeseburger on a bun' was investigated. The average D-10 values, the radiation dose needed to inactivate 1 log{sub 1} of pathogen, by bacterium species, were 0.61, 0.54, 0.47, 0.36 and 0.15 kGy for Salmonella spp., S. aureus, L. monocytogenes, E. coli O157:H7, and Y. enterocolitica, respectively when inoculated onto the three product types. These results indicate that irradiation may be an effective means for inactivating common foodborne pathogens including Salmonella spp, S. aureus, L. monocytogenes, E. coli O157:H7 and Y. enterocolitica in complex RTE food products such as 'heat and eat' sandwich products.

  20. Seeking the Important Nodes of Complex Networks in Product R&D Team Based on Fuzzy AHP and TOPSIS

    Directory of Open Access Journals (Sweden)

    Wei Zhang

    2013-01-01

    Full Text Available How to seek the important nodes of complex networks in product research and development (R&D team is particularly important for companies engaged in creativity and innovation. The previous literature mainly uses several single indicators to assess the node importance; this paper proposes a multiple attribute decision making model to tentatively solve these problems. Firstly, choose eight indicators as the evaluation criteria, four from centralization of complex networks: degree centrality, betweenness centrality, closeness centrality, and eigenvector centrality and four from structural holes of complex networks: effective size, efficiency, constraint, and hierarchy. Then, use fuzzy analytic hierarchy process (AHP to obtain the weights of these indicators and use technique for order preference by similarity to an ideal solution (TOPSIS to assess the importance degree of each node of complex networks. Finally, taking a product R&D team of a game software company as a research example, test the effectiveness, operability, and efficiency of the method we established.

  1. Quantitative analytical hierarchy process to marketing store location selection

    Directory of Open Access Journals (Sweden)

    Harwati

    2018-01-01

    Full Text Available The selection of Store to market the product is belong to Multi Criteria Decision Making problem. The criteria used have conflict of interest with each other to produce an optimal location. This research uses four important criteria to select new location of marketing store appropriate with the references: distance to location, competition level with competitor, number of potential customer, and location rent cost. Quantitative data is used to determine the optimum location with AHP method. Quantitative data are preferred to avoid inconsistency when using expert opinion. The AHP result optimum location among three alternatives places.

  2. Similar Transition States Mediate the Q-cycle and Superoxide Production by the Cytochrome bc1 Complex

    International Nuclear Information System (INIS)

    Forquer, Isaac P.; Covian, Raul; Bowman, Michael K.; Trumpower, Bernard; Kramer, David M.

    2006-01-01

    The cytochrome bc complexes found in mitochondria, chloroplasts and many bacteria catalyze a critical reaction in their respective electron transport chains. The quinol oxidase (Qo) site in this complex oxidizes a hydroquinone (quinol), reducing two one-electron carriers, a low-potential cytochrome b heme and a ''Rieske'' iron-sulfur cluster. The overall electron transfer reactions are coupled to transmembrane translocation of protons via a ''Q-cycle'' mechanism, which generates proton motive force for ATP synthesis. Since semiquinone intermediates of quinol oxidation are generally highly reactive, one of the key questions in this field is: how does the Qo site oxidize quinol without the production of deleterious side reactions including superoxide production? We attempt to test three possible general models to account for this behavior: (1) The Qo site semiquinone (or quinol:imidazolate complex) is unstable and thus occurs at a very low steady-state concentration, limiting O2 reduction; (2) the Qo site semiquinone is highly stabilized making it unreactive towards oxygen; and (3) the Qo site catalyzes a quantum mechanically-coupled two-electron/two proton transfer without a semiquinone intermediate. Enthalpies of activation were found to be almost identical between the uninhibited Q-cycle and superoxide production in the presence of Antimycin A in wild type. This behavior was also preserved in a series of mutants with altered driving forces for quinol oxidation. Overall, the data supports models where the rate-limiting step for both Q-cycle and superoxide production are essentially identical, consistent with model 1 but requiring modifications to models 2 and 3

  3. Multi-organ technetium complexes production and use thereof

    International Nuclear Information System (INIS)

    Koehler, G.A.; Pestel, G.M.

    1976-01-01

    Chemical complexes, useful as radiopharmaceuticals, are formed by reacting technetium-99m with substituted or unsubstituted alkyl monophosphonic acids and certain ester derivatives thereof. The complexes are formed by reducing pertechnetate ion chemically or electrolytically in the presence of the phosphonic acid. By chemical modification of the phosphonic acid complexing agent, it is possible to ''tailor'' complexes for kidney, liver or bone imaging. The complexes are normally used in a physiologically acceptable aqueous medium. 20 Claims, No Drawings

  4. Prediction of Increasing Production Activities using Combination of Query Aggregation on Complex Events Processing and Neural Network

    Directory of Open Access Journals (Sweden)

    Achmad Arwan

    2016-07-01

    Full Text Available AbstrakProduksi, order, penjualan, dan pengiriman adalah serangkaian event yang saling terkait dalam industri manufaktur. Selanjutnya hasil dari event tersebut dicatat dalam event log. Complex Event Processing adalah metode yang digunakan untuk menganalisis apakah terdapat pola kombinasi peristiwa tertentu (peluang/ancaman yang terjadi pada sebuah sistem, sehingga dapat ditangani secara cepat dan tepat. Jaringan saraf tiruan adalah metode yang digunakan untuk mengklasifikasi data peningkatan proses produksi. Hasil pencatatan rangkaian proses yang menyebabkan peningkatan produksi digunakan sebagai data latih untuk mendapatkan fungsi aktivasi dari jaringan saraf tiruan. Penjumlahan hasil catatan event log dimasukkan ke input jaringan saraf tiruan untuk perhitungan nilai aktivasi. Ketika nilai aktivasi lebih dari batas yang ditentukan, maka sistem mengeluarkan sinyal untuk meningkatkan produksi, jika tidak, sistem tetap memantau kejadian. Hasil percobaan menunjukkan bahwa akurasi dari metode ini adalah 77% dari 39 rangkaian aliran event.Kata kunci: complex event processing, event, jaringan saraf tiruan, prediksi peningkatan produksi, proses. AbstractProductions, orders, sales, and shipments are series of interrelated events within manufacturing industry. Further these events were recorded in the event log. Complex event processing is a method that used to analyze whether there are patterns of combinations of certain events (opportunities / threats that occur in a system, so it can be addressed quickly and appropriately. Artificial neural network is a method that we used to classify production increase activities. The series of events that cause the increase of the production used as a dataset to train the weight of neural network which result activation value. An aggregate stream of events inserted into the neural network input to compute the value of activation. When the value is over a certain threshold (the activation value results

  5. Location, location, location

    NARCIS (Netherlands)

    Anderson, S.P.; Goeree, J.K.; Ramer, R.

    1997-01-01

    We analyze the canonical location-then-price duopoly game with general log- concave consumer densities. A unique pure-strategy equilibrium to the two-stage game exists if the density is not "too asymmetric" and not "too concave." These criteria are satisfied by many commonly used densities.

  6. Impact of product development efforts on product introduction and product customization abilities

    DEFF Research Database (Denmark)

    Chaudhuri, Atanu; Dawar, Saloni

    2014-01-01

    This paper investigates the impact of efforts in new product development-manufacturing integration (NPDMI) on new product introduction (NPI) and product customization (PC) abilities and the moderating effects of product design complexity and importance of new product development order winners...... (NPIOW) on the above relationships. The results from the data on 136 Indian manufacturing plants show that NPDMI, product design complexity and NPIOW all have significant positive impact on NPI and PC abilities. Importance of NPIOW has a positive moderating effect on the relationship between NPDMI and PC...... ability change but product design complexity demonstrate no such effect on the above relationships....

  7. Seasonal patterns of phytoplankton biomass and productivity in a tropical estuarine complex (west coast of India)

    Digital Repository Service at National Institute of Oceanography (India)

    Devassy, V.P.; Goes, J.I.

    Phytoplankton cell numbers and chlorophyll a determinations were made during the premonsoon, monsoon and postmonsoon periods in the Mandovi-Zuari estuarine complex (west coast of India). Primary productivity estimates agreed well with chlorophyll a...

  8. Complexation of Cu2+, Ni2+ and UO22+ by radiolytic degradation products of bitumen

    International Nuclear Information System (INIS)

    Loon, L.R. Van; Kopajtic, Z.

    1990-05-01

    The radiolytic degradation of bitumen was studied under conditions which reflect those which will exist in the near field of a cementitious radioactive waste repository. The potential complexation capacity of the degradation products was studied and complexation experiments with Cu 2+ , Ni 2+ and UO 2 2+ were performed. In general 1:1 complexes with Cu 2+ , Ni 2+ and UO 2 2+ , with log K values of between 5.7 and 6.0 for Cu 2+ , 4.2 for Ni 2+ and 6.1 for UO 2 2+ , were produced at an ionic strength of 0.1 M. The composition of the bitumen water was analysed by GC-MS and IC. The major proportion of the bitumen degradation products in solution were monocarboxylic acids (acetic acid, formic acid, myric acid, stearic acid ...), dicarboxylic acids (oxalic acid, phthalic acid) and carbonates. The experimentally derived log K data are in good agreement with the literature and suggest that oxalate determines the speciation of Cu 2+ , Ni 2+ and UO 2 2+ in the bitumen water below pH=7. However, under the high pH conditions typical of the near field of a cementitious repository, competition with OH-ligands will be large and oxalate, therefore, will not play a significant role in the speciation of radionuclides. The main conclusion of the study is that the radiolytic degradation products of bitumen will have no influence on radionuclide speciation in a cementitious near field and, as such, need not to be considered in the appropriate safety assessment models. (author) 12 figs., 11 tabs., 31 refs

  9. If it's not there, where is it? Locating illusory conjunctions.

    Science.gov (United States)

    Hazeltine, R E; Prinzmetal, W; Elliott, W

    1997-02-01

    There is evidence that complex objects are decomposed by the visual system into features, such as shape and color. Consistent with this theory is the phenomenon of illusory conjunctions, which occur when features are incorrectly combined to form an illusory object. We analyzed the perceived location of illusory conjunctions to study the roles of color and shape in the location of visual objects. In Experiments 1 and 2, participants located illusory conjunctions about halfway between the veridical locations of the component features. Experiment 3 showed that the distribution of perceived locations was not the mixture of two distributions centered at the 2 feature locations. Experiment 4 replicated these results with an identification task rather than a detection task. We concluded that the locations of illusory conjunctions were not arbitrary but were determined by both constituent shape and color.

  10. QCD corrections to squark production in e+ e- annihilation in the MSSM with complex parameters

    International Nuclear Information System (INIS)

    Nguyen Thi Thu Huong; Ha Huy Bang; Nguyen Chinh Cuong; Dao Thi Le Thuy

    2004-11-01

    We discuss the pair production of scalar quarks in e + e - annihilation within the MSSM with complex parameters. We calculate the SUSY-QCD corrections to the cross section e + e - → q-tilde i q-bar-tilde j (i, j 1, 2) and show that the effect of the CP phases of these complex parameters on the cross section can be quite strong in a large region of the MSSM parameter space. This could have important implications for squarks searches and the MSSM parameter determination in future collider experiments. (author)

  11. Simulation study of the production of biodiesel using feedstock mixtures of fatty acids in complex reactive distillation columns

    International Nuclear Information System (INIS)

    Cossio-Vargas, E.; Hernandez, S.; Segovia-Hernandez, J.G.; Cano-Rodriguez, M.I.

    2011-01-01

    Biodiesel can be produced from a number of natural, renewable sources, but vegetable oils are the main feedstocks. The current manufacturing biodiesel processes, however, have several disadvantages: expensive separation of products from the reaction mixture, and high costs due to relatively complex processes involving one to two reactors and several separation units. Therefore, to solve these problems, in recent years several researchers have developed a sustainable biodiesel production process based on reactive distillation. In this paper the production of biodiesel using feedstock mixtures of fatty acids is explored using reactive distillation sequences with thermal coupling. The results indicate that the complex reactive distillation sequences can produce a mixture of esters as bottoms product that can be used as biodiesel. In particular, the thermally coupled distillation sequence involving a side rectifier can handle the reaction and complete separation in accordance with process intensification principles. -- Highlights: ► Production of biodiesel using thermally coupled distillation sequences without reboilers. ► Esterification of fatty organic acids using reactive distillation. ► Carnot’s factor in reactive distillation.

  12. Structure and mechanism leading to formation of the cysteine sulfinate product complex of a biomimetic cysteine dioxygenase model.

    Science.gov (United States)

    Sallmann, Madleen; Kumar, Suresh; Chernev, Petko; Nehrkorn, Joscha; Schnegg, Alexander; Kumar, Devesh; Dau, Holger; Limberg, Christian; de Visser, Sam P

    2015-05-11

    Cysteine dioxygenase is a unique nonheme iron enzyme that is involved in the metabolism of cysteine in the body. It contains an iron active site with an unusual 3-His ligation to the protein, which contrasts with the structural features of common nonheme iron dioxygenases. Recently, some of us reported a truly biomimetic model for this enzyme, namely a trispyrazolylborato iron(II) cysteinato complex, which not only has a structure very similar to the enzyme-substrate complex but also represents a functional model: Treatment of the model with dioxygen leads to cysteine dioxygenation, as shown by isolating the cysteine part of the product in the course of the work-up. However, little is known on the conversion mechanism and, so far, not even the structure of the actual product complex had been characterised, which is also unknown in case of the enzyme. In a multidisciplinary approach including density functional theory calculations and X-ray absorption spectroscopy, we have now determined the structure of the actual sulfinato complex for the first time. The Cys-SO2 (-) functional group was found to be bound in an η(2) -O,O-coordination mode, which, based on the excellent resemblance between model and enzyme, also provides the first support for a corresponding binding mode within the enzymatic product complex. Indeed, this is again confirmed by theory, which had predicted a η(2) -O,O-binding mode for synthetic as well as the natural enzyme. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  13. Transition Metal Chelator Induces Progesterone Production in Mouse Cumulus-Oocyte Complexes and Corpora Lutea.

    Science.gov (United States)

    Tian, X; Anthony, K; Diaz, Francisco J

    2017-04-01

    Progesterone production is upregulated in granulosa cells (cumulus and mural) after the LH surge, but the intra-follicular mechanisms regulating this transition are not completely known. Recent findings show that the transition metal chelator, N,N,N',N'-tetrakis-(2-pyridylmethyl)-ethylenediamine (TPEN), impairs ovarian function. In this study, we provide evidence that chelating transition metals, including zinc, enhances progesterone production. The findings show that TPEN (transition metal chelator) increases abundance of Cyp11a1 and Star messenger RNA (mRNA) between 8- and 20-fold and progesterone production more than 3-fold in cultured cumulus-oocyte complexes (COC). Feeding a zinc-deficient diet for 10 days, but not 3 days, increased Star, Hsd3b, and prostaglandin F2 alpha receptor (Ptgfr) mRNA ~2.5-fold, suggesting that the effect of TPEN is through modulation of zinc availability. Progesterone from cumulus cells promotes oocyte developmental potential. Blocking progesterone production with epostane during maturation reduced subsequent blastocyst formation from 89 % in control to 18 % in epostane-treated complexes, but supplementation with progesterone restored blastocyst developmental potential to 94 %. Feeding a zinc-deficient diet for 5 days before ovulation did not affect the number of CL, STAR protein, or serum progesterone. However, incubating luteal tissue with TPEN increased abundance of Star, Hsd3b, and Ptgfr mRNA 2-3-fold and increased progesterone production 3-fold. TPEN is known to abolish SMAD2/3 signaling in cumulus cells. However, treatment of COC with the SMAD2/3 phosphorylation inhibitor, SB421542, did not by itself induce steroidogenic transcripts but did potentiate EGF-induced Star mRNA expression. Collectively, the results show that depletion of transition metals with TPEN acutely enhances progesterone biosynthesis in COC and luteal tissue.

  14. Practice of building production planning system of company with a wide range of products - case study

    Directory of Open Access Journals (Sweden)

    Łukasz Hadaś

    2012-09-01

    Full Text Available Background: The complexity of the manufacturing environments of today's mechanical engineering companies and the number of both internal and external restrictions affecting to need of building tailored production planning and control systems. This statement is particularly important in conditions of companies with a wide range of products and different customer service strategies (different locations of the logistics decoupling point otherwise called "order penetration point". Streams of materials in these conditions require different management what is the main reason for carrying out research in business conditions by the authors. Material and methods: The research was carried out in industrial engineering in complex environmental conditions of production. This was a specializing in technology, multi-departments environment, with multiple streams of values and a wide range of products (about 500 items. The work was carried out under the transformation of the production system from the "push" logic of flow to "pull" logic of flow and building a dedicated system based on the best practice approach. Results: The paper describes the process of building tailored hybrid systems in the area of planning and shop flow control of production. The authors present the theoretical considerations on the issue and practical experiences. The authors present factors of selection of the transformation path and its road map. The article describes the part of the authors' own experience in the work on the methodology of transformation of Polish companies in the running business condition. Conclusions: Establishing the methodology of transformation of the production system is not a simple task. This paper presents only selected aspects of complex decision-making process. However, the authors presented work shows the important aspect of the transformation of production systems for these organizational conditions.

  15. Sodium ferric gluconate (SFG) in complex with sucrose for IV infusion: bioequivalence of a new generic product with the branded product in healthy volunteers.

    Science.gov (United States)

    Baribeault, David

    2011-08-01

    Parenteral sodium ferric gluconate in complex (Ferrlecit [branded SFG]) is used to treat patients with iron deficiency anemia undergoing chronic hemodialysis and receiving supplemental epoetin. This comparative pharmacokinetic study (GeneraMedix, Inc., Study 17909) evaluates whether the recently approved generic product Nulecit (generic SFG) and the branded product Ferrlecit (branded SFG) are bioequivalent. In this open-label study, 240 healthy volunteers in a fasting state were assigned randomly to a single 10-min intravenous (IV) infusion of 125 mg of generic or branded SFG. Total and transferrin-bound iron concentrations were determined for the 36-h period after infusion and corrected for pretreatment levels. Maximum concentration (Cmax) and area under the concentration-time curve of 0 to 36 h (AUC[0-36]) were compared between the two products. Demonstration of bioequivalence required that the 90% confidence intervals of each parameter evaluated for generic SFG were within 80% to 125% of the corresponding values for branded SFG. Uncorrected and baseline-corrected mean serum concentrations of total serum iron during the 36-h assessment period were similar for generic and branded SFG. For total serum iron, the geometric mean ratios of corrected Cmax and AUC[0-36] were 100%. For transferrin-bound iron, the geometric mean ratios were 87% for corrected Cmax and 92% for corrected AUC[0-36]. All associated 90% confidence intervals were within the range of 80% to 125%. A new generic SFG in complex for IV infusion is bioequivalent to the branded SFG in complex for IV infusion. The generic SFG is AB rated by the FDA and considered therapeutically equivalent to the branded product.

  16. Inferring Stop-Locations from WiFi.

    Directory of Open Access Journals (Sweden)

    David Kofoed Wind

    Full Text Available Human mobility patterns are inherently complex. In terms of understanding these patterns, the process of converting raw data into series of stop-locations and transitions is an important first step which greatly reduces the volume of data, thus simplifying the subsequent analyses. Previous research into the mobility of individuals has focused on inferring 'stop locations' (places of stationarity from GPS or CDR data, or on detection of state (static/active. In this paper we bridge the gap between the two approaches: we introduce methods for detecting both mobility state and stop-locations. In addition, our methods are based exclusively on WiFi data. We study two months of WiFi data collected every two minutes by a smartphone, and infer stop-locations in the form of labelled time-intervals. For this purpose, we investigate two algorithms, both of which scale to large datasets: a greedy approach to select the most important routers and one which uses a density-based clustering algorithm to detect router fingerprints. We validate our results using participants' GPS data as well as ground truth data collected during a two month period.

  17. Application of ant colony optimization in NPP classification fault location

    International Nuclear Information System (INIS)

    Xie Chunli; Liu Yongkuo; Xia Hong

    2009-01-01

    Nuclear Power Plant is a highly complex structural system with high safety requirements. Fault location appears to be particularly important to enhance its safety. Ant Colony Optimization is a new type of optimization algorithm, which is used in the fault location and classification of nuclear power plants in this paper. Taking the main coolant system of the first loop as the study object, using VB6.0 programming technology, the NPP fault location system is designed, and is tested against the related data in the literature. Test results show that the ant colony optimization can be used in the accurate classification fault location in the nuclear power plants. (authors)

  18. Location and social context does matter when conducting consumer studies!

    DEFF Research Database (Denmark)

    Andersen, Barbara Vad; Kraggerud, Hilde; Bruun Brockhoff, Per

    2015-01-01

    an adequate level of research conducted in realistic eating contexts. In the aim to study how location and social context affected consumers’ feeling of food satisfaction and physical well-being a study was set up with, combined yoghurt with muesli products in two settings; a) in a sensory lab facility (n...... of food satisfaction. Test products were two variants of yoghurt (differing in protein content) and two variants of muesli (a berry and a nut variant) eaten as combined products. An effect of location context (lab- vs. natural context) was found for immediate post intake rating of hunger, fullness...

  19. Location of an intermediate hub for port activities

    Science.gov (United States)

    Burciu, Ş.; Ştefănică, C.; Roşca, E.; Dragu, V.; Ruscă, F.

    2015-11-01

    An intermediate hub might increase the accessibility level of ports but also hinterland and so it can be considered more than a facility with a transhipment role. These hubs might lead to the development of other transport services and enhance their role in gathering and covering economic centres within hinterlands and also getting the part of logistic facility for the ports, with effects on port utilization and its connectivity to global economy. A new location for a hub terminal leads to reduced transport distances within hinterland, with decreased transport costs and external effects, so with gains in people's life quality. Because the production and distribution systems are relatively fixed on short and medium term and the location decisions are strategic and on long term, the logistic chains activities location models have to consider the uncertainties regarding the possible future situations. In most models, production costs are considered equal, the location problem reducing itself to a problem that aims to minimize the total transport costs, meaning the transport problem. The main objective of the paper is to locate a hub terminal that links the producers of cereals that are going to be exported by naval transportation with the Romanian fluvial-maritime ports (Galaţi, Brăila). GIS environment can be used to integrate and analyse a great amount of data and has the ability of using functions as location - allocation models necessary both to private and public sector, being able to determine the optimal location for services like factories, warehouses, logistic platforms and other public services.

  20. Complex nuclear-structure phenomena revealed from the nuclide production in fragmentation reactions

    International Nuclear Information System (INIS)

    Ricciardi, M.V.; Kelic, A.; Napolitani, P.; Schmidt, K.H.; Yordanov, O.; Ignatyuk, A.V.; Rejmund, F.

    2003-12-01

    Complex structural effects in the nuclide production from the projectile fragmentation of 1 A GeV 238 U nuclei in a titanium target are reported. The structure seems to be insensitive to the excitation energy induced in the reaction. This is in contrast to the prominent structural features found in nuclear fission and in transfer reactions, which gradually disappear with increasing excitation energy. Using the statistical model of nuclear reactions, relations to structural effects in nuclear binding and in the nuclear level density are demonstrated. (orig.)

  1. Complexity Management - A multiple case study analysis on control and reduction of complexity costs

    DEFF Research Database (Denmark)

    Myrodia, Anna

    of products, with features more custom-made to cover individual needs, both regarding characteristics of products and support services. This necessity leads to a considerable increase of the complexity in the company, which affects the product portfolio, production and supply chain, market segments......, IT systems, and business processes. In order to identify and eliminate complexity, several approaches are used, both by researchers and practitioners. The purpose of this thesis is to contribute to the existing knowledge of complexity management theory. This research focuses on the relationship between......Complexity tends to be arguably the biggest challenge of manufacturing companies. The motivation of further studying complexity is a combination between the existing literature and the practical experiences from the industry. Based on the latest trend companies are trying to supply a growing mix...

  2. Top-Down and Bottom-Up Approach for Model-Based Testing of Product Lines

    Directory of Open Access Journals (Sweden)

    Stephan Weißleder

    2013-03-01

    Full Text Available Systems tend to become more and more complex. This has a direct impact on system engineering processes. Two of the most important phases in these processes are requirements engineering and quality assurance. Two significant complexity drivers located in these phases are the growing number of product variants that have to be integrated into the requirements engineering and the ever growing effort for manual test design. There are modeling techniques to deal with both complexity drivers like, e.g., feature modeling and model-based test design. Their combination, however, has been seldom the focus of investigation. In this paper, we present two approaches to combine feature modeling and model-based testing as an efficient quality assurance technique for product lines. We present the corresponding difficulties and approaches to overcome them. All explanations are supported by an example of an online shop product line.

  3. Mobile location with NLOS identification and mitigation based on modified Kalman filtering.

    Science.gov (United States)

    Ke, Wei; Wu, Lenan

    2011-01-01

    In order to enhance accuracy and reliability of wireless location in the mixed line-of-sight (LOS) and non-line-of-sight (NLOS) environments, a robust mobile location algorithm is presented to track the position of a mobile node (MN). An extended Kalman filter (EKF) modified in the updating phase is utilized to reduce the NLOS error in rough wireless environments, in which the NLOS bias contained in each measurement range is estimated directly by the constrained optimization method. To identify the change of channel situation between NLOS and LOS, a low complexity identification method based on innovation vectors is proposed. Numerical results illustrate that the location errors of the proposed algorithm are all significantly smaller than those of the iterated NLOS EKF algorithm and the conventional EKF algorithm in different LOS/NLOS conditions. Moreover, this location method does not require any statistical distribution knowledge of the NLOS error. In addition, complexity experiments suggest that this algorithm supports real-time applications.

  4. Prevention of Acid Mine Drainage Through Complexation of Ferric Iron by Soluble Microbial Growth Products

    Science.gov (United States)

    Pandey, S.; Yacob, T. W.; Silverstein, J.; Rajaram, H.; Minchow, K.; Basta, J.

    2011-12-01

    Acid mine drainage (AMD) is a widespread environmental problem with deleterious impacts on water quality in streams and watersheds. AMD is generated largely by the oxidation of metal sulfides (i.e. pyrite) by ferric iron. This abiotic reaction is catalyzed by conversion of ferrous to ferric iron by iron and sulfur oxidizing microorganisms. Biostimulation is currently being investigated as an attempt to inhibit the oxidation of pyrite and growth of iron oxidizing bacteria through addition of organic carbon. This may stimulate growth of indigenous communities of acidophilic heterotrophic bacteria to compete for oxygen. The goal of this research is to investigate a secondary mechanism associated with carbon addition: complexation of free Fe(III) by soluble microbial growth products (SMPs) produced by microorganisms growing in waste rock. Exploratory research at the laboratory scale examined the effect of soluble microbial products (SMPs) on the kinetics of oxidation of pure pyrite during shaker flask experiments. The results confirmed a decrease in the rate of pyrite oxidation that was dependent upon the concentration of SMPs in solution. We are using these data to verify results from a pyrite oxidation model that accounts for SMPs. This reactor model involves differential-algebraic equations incorporating total component mass balances and mass action laws for equilibrium reactions. Species concentrations determined in each time step are applied to abiotic pyrite oxidation rate expressions from the literature to determine the evolution of total component concentrations. The model was embedded in a parameter estimation algorithm to determine the reactive surface area of pyrite in an abiotic control experiment, yielding an optimized value of 0.0037 m2. The optimized model exhibited similar behavior to the experiment for this case; the root mean squared of residuals for Fe(III) was calculated to be 7.58 x 10-4 M, which is several orders of magnitude less than the actual

  5. Location audio simplified capturing your audio and your audience

    CERN Document Server

    Miles, Dean

    2014-01-01

    From the basics of using camera, handheld, lavalier, and shotgun microphones to camera calibration and mixer set-ups, Location Audio Simplified unlocks the secrets to clean and clear broadcast quality audio no matter what challenges you face. Author Dean Miles applies his twenty-plus years of experience as a professional location operator to teach the skills, techniques, tips, and secrets needed to produce high-quality production sound on location. Humorous and thoroughly practical, the book covers a wide array of topics, such as:* location selection* field mixing* boo

  6. Stochastic production phase design for an open pit mining complex with multiple processing streams

    Science.gov (United States)

    Asad, Mohammad Waqar Ali; Dimitrakopoulos, Roussos; van Eldert, Jeroen

    2014-08-01

    In a mining complex, the mine is a source of supply of valuable material (ore) to a number of processes that convert the raw ore to a saleable product or a metal concentrate for production of the refined metal. In this context, expected variation in metal content throughout the extent of the orebody defines the inherent uncertainty in the supply of ore, which impacts the subsequent ore and metal production targets. Traditional optimization methods for designing production phases and ultimate pit limit of an open pit mine not only ignore the uncertainty in metal content, but, in addition, commonly assume that the mine delivers ore to a single processing facility. A stochastic network flow approach is proposed that jointly integrates uncertainty in supply of ore and multiple ore destinations into the development of production phase design and ultimate pit limit. An application at a copper mine demonstrates the intricacies of the new approach. The case study shows a 14% higher discounted cash flow when compared to the traditional approach.

  7. Developmental Changes in Locating Voice and Sound in Space

    Science.gov (United States)

    Kezuka, Emiko; Amano, Sachiko; Reddy, Vasudevi

    2017-01-01

    We know little about how infants locate voice and sound in a complex multi-modal space. Using a naturalistic laboratory experiment the present study tested 35 infants at 3 ages: 4 months (15 infants), 5 months (12 infants), and 7 months (8 infants). While they were engaged frontally with one experimenter, infants were presented with (a) a second experimenter’s voice and (b) castanet sounds from three different locations (left, right, and behind). There were clear increases with age in the successful localization of sounds from all directions, and a decrease in the number of repetitions required for success. Nonetheless even at 4 months two-thirds of the infants attempted to search for the voice or sound. At all ages localizing sounds from behind was more difficult and was clearly present only at 7 months. Perseverative errors (looking at the last location) were present at all ages and appeared to be task specific (only present in the 7 month-olds for the behind location). Spontaneous attention shifts by the infants between the two experimenters, evident at 7 months, suggest early evidence for infant initiation of triadic attentional engagements. There was no advantage found for voice over castanet sounds in this study. Auditory localization is a complex and contextual process emerging gradually in the first half of the first year. PMID:28979220

  8. Three formulations of the multi-type capacitated facility location problem

    DEFF Research Database (Denmark)

    Klose, Andreas

    The "multi-type" or "modular" capacitated facility location problem is a discrete location model that addresses non-convex piecewise linear production costs as, for instance, staircase cost functions. The literature basically distinguishes three different ways to formulate non-convex piecewise...

  9. Complex Neutrosophic Subsemigroups and Ideals

    Directory of Open Access Journals (Sweden)

    Muhammad Gulistan

    2018-01-01

    Full Text Available In this article we study the idea of complex neutrosophic subsemigroups. We define the Cartesian product of complex neutrosophic subsemigroups, give some examples and study some of its related results. We also define complex neutrosophic (left, right, interior ideal in semigroup. Furthermore, we introduce the concept of characteristic function of complex neutrosophic sets, direct product of complex neutrosophic sets and study some results prove on its.

  10. CD147 is a regulatory subunit of the gamma-secretase complex inAlzheimer's disease amyloid beta-peptide production

    Energy Technology Data Exchange (ETDEWEB)

    Zhou, Shuxia; Zhou, Hua; Walian, Peter J.; Jap, Bing K.

    2005-04-06

    {gamma}-secretase is a membrane protein complex that cleaves the {beta}-amyloid precursor protein (APP) within the transmembrane region, following prior processing by {beta}-secretase, producing amyloid {beta}-peptides (A{beta}{sub 40} and A{beta}{sub 42}). Errant production of A{beta}-peptides that substantially increases A{beta}{sub 42} production has been associated with the formation of amyloid plaques in Alzheimer's disease patients. Biophysical and genetic studies indicate that presenilin-1 (Psn-1), which contains the proteolytic active site, and three other membrane proteins, nicastrin (Nct), APH-1, and PEN-2 are required to form the core of the active {gamma}-secretase complex. Here, we report the purification of the native {gamma}-secretase complexes from HeLa cell membranes and the identification of an additional {gamma}-secretase complex subunit, CD147, a transmembrane glycoprotein with two immunoglobulin-like domains. The presence of this subunit as an integral part of the complex itself was confirmed through co-immunoprecipitation studies of the purified protein from HeLa cells and solubilized complexes from other cell lines such as neural cell HCN-1A and HEK293. Depletion of CD147 by RNA interference was found to increase the production of A{beta} peptides without changing the expression level of the other {gamma}-secretase components or APP substrates while CD147 overexpression had no statistically significant effect on amyloid {beta}-peptide production, other {gamma}-secretase components or APP substrates, indicating that the presence of the CD147 subunit within the {gamma}-secretase complex directly down-modulates the production of A{beta}-peptides. {gamma}-secretase was first recognized through its role in the production of the A{beta} peptides that are pathogenic in Alzheimer's disease (AD) (1). {gamma}-secretase is a membrane protein complex with unusual aspartyl protease activity that cleaves a variety of type I membrane proteins

  11. A power set-based statistical selection procedure to locate susceptible rare variants associated with complex traits with sequencing data.

    Science.gov (United States)

    Sun, Hokeun; Wang, Shuang

    2014-08-15

    Existing association methods for rare variants from sequencing data have focused on aggregating variants in a gene or a genetic region because of the fact that analysing individual rare variants is underpowered. However, these existing rare variant detection methods are not able to identify which rare variants in a gene or a genetic region of all variants are associated with the complex diseases or traits. Once phenotypic associations of a gene or a genetic region are identified, the natural next step in the association study with sequencing data is to locate the susceptible rare variants within the gene or the genetic region. In this article, we propose a power set-based statistical selection procedure that is able to identify the locations of the potentially susceptible rare variants within a disease-related gene or a genetic region. The selection performance of the proposed selection procedure was evaluated through simulation studies, where we demonstrated the feasibility and superior power over several comparable existing methods. In particular, the proposed method is able to handle the mixed effects when both risk and protective variants are present in a gene or a genetic region. The proposed selection procedure was also applied to the sequence data on the ANGPTL gene family from the Dallas Heart Study to identify potentially susceptible rare variants within the trait-related genes. An R package 'rvsel' can be downloaded from http://www.columbia.edu/∼sw2206/ and http://statsun.pusan.ac.kr. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  12. The Location of Digital Ethnography

    Directory of Open Access Journals (Sweden)

    Dana M. Walker

    2010-10-01

    Full Text Available Qualitative researchers interested in digitally-located social and cultural practices have struggled with ways in which to design studies that can account for the digital aspect of cultural practices while also taking into account that those digital practices do not exist as separate (or separable in terms of our research from other social and cultural practices. As such, one of the primary and ongoing challenges facing internet-based ethnographic research is the question of how to construct the location of a project when the sites, technologically-mediated practices, and people we study exist and flow through a wider information ecology that is neither fixed nor can easily be located as “online” or “offline.” This is as much a methodological challenge as a theoretical one. If one accepts that a rigid distinction between online and offline makes little theoretical sense, then drawing a methodological line between online and offline only reifies such a dualism. While there is a developing body of internet-related ethnographic literature which is attempting to take into account the fluid nature of our information ecology (e.g. Burrell, 2009, Leander and McKim, 2003, Hine, 2007, we continue to operate on shifting ground. This article uses the case of my own work on city-specific discussion forums in Philadelphia, Pennsylvania to highlight the complexities of locating digital ethnographic work and also argue for the necessity of accounting for both movement and placed-ness.

  13. LEGO products have become more complex.

    Science.gov (United States)

    Bartneck, Christoph; Moltchanova, Elena

    2018-01-01

    The LEGO Group has become the largest toy company in the world and they can look back to a proud history of more than 50 years of producing bricks and other toys. Starting with a simple set of basic bricks their range of toys appeared to have increased in complexity over the years. We processed the inventories of most sets from 1955-2015 and our analysis showed that LEGO sets have become bigger, more colorful and more specialized. The vocabulary of bricks has increased significantly resulting in sets sharing fewer bricks. The increased complexity of LEGO sets and bricks enables skilled builders to design ever more amazing models but it may also overwhelm less skilled or younger builders.

  14. The Synthesis of 58co-Naphthenate Complex Compound for Evaluation of Oil well Production Capacity

    International Nuclear Information System (INIS)

    Duyeh Setiawan; Marlina

    2009-01-01

    The nuclear technique using radioisotope as a tracer in oil industry has assisted to solve the degradation of oil production. Usually, the degradation of oil production in well caused by the formation changing of hydrostatic pressure of the oil layer in the well. This problem could be evaluated by injection of water to oil well, for recovering this hydrostatic pressure. The watcher of the water injection success is done by the way of nuclear technique radioactive tracer systems, applied radioisotope having short half life and low gamma radiation energy. Radioisotope cobalt-58 in the complex form with naphthenate ( 58 Co-naphthenate ) often used as the tracer in the water injection technique. The tracer 58 Co-naphthenate relatively easy to synthesis and radioisotope 58 Co has half life 70.86 days and gamma energy was 0.811 Me v. The synthesis method of 58 Co-naphthenate route has been carried out by mixing of 58 CoCl 2 radioisotope solution with sodium naphthenate (C 5 H 9 CH 2 COONa) in the optimum condition. The results shows that the optimal mole ratio of cobalt-58 and naphthenate was 1:6 which produced 87,38 % of ren dement and 82,5 % of efficiency labelling. This synthesis technique was made permanent procedure for making of 58 Co-naphthenate complex as radioactive tracer in service of radioisotope production especially industrial area. (author)

  15. Phenomenology of on-shell Higgs production in the MSSM with complex parameters

    Energy Technology Data Exchange (ETDEWEB)

    Liebler, Stefan; Patel, Shruti; Weiglein, Georg [DESY, Hamburg (Germany)

    2017-05-15

    A computation of inclusive cross sections for neutral Higgs boson production through gluon fusion and bottom-quark annihilation is presented in the MSSM with complex parameters. The predictions for the gluon-fusion process are based on an explicit calculation of the leading-order cross section for arbitrary complex parameters which is supplemented by higher-order corrections: massive top- and bottom-quark contributions at NLO QCD, in the heavy top-quark effective theory the top-quark contribution up to N{sup 3}LO QCD including a soft expansion for the CP-even component of the light Higgs boson. For its CP-odd component and the heavy Higgs bosons the contributions are incorporated up to NNLO QCD. Two-loop electroweak effects are also incorporated, and SUSY QCD corrections at NLO are interpolated from the MSSM with real parameters. Finite wave function normalisation factors ensuring correct on-shell properties of the external Higgs bosons are incorporated from the code FeynHiggs. For the typical case of a strong admixture of the two heavy Higgs bosons it is demonstrated that squark effects are strongly dependent on the phases of the complex parameters. The remaining theoretical uncertainties for cross sections are discussed. The results have been implemented into an extension of the numerical code SusHi called SusHiMi. (orig.)

  16. LEGO products have become more complex.

    Directory of Open Access Journals (Sweden)

    Christoph Bartneck

    Full Text Available The LEGO Group has become the largest toy company in the world and they can look back to a proud history of more than 50 years of producing bricks and other toys. Starting with a simple set of basic bricks their range of toys appeared to have increased in complexity over the years. We processed the inventories of most sets from 1955-2015 and our analysis showed that LEGO sets have become bigger, more colorful and more specialized. The vocabulary of bricks has increased significantly resulting in sets sharing fewer bricks. The increased complexity of LEGO sets and bricks enables skilled builders to design ever more amazing models but it may also overwhelm less skilled or younger builders.

  17. Improvement Schemes for Indoor Mobile Location Estimation: A Survey

    Directory of Open Access Journals (Sweden)

    Jianga Shang

    2015-01-01

    Full Text Available Location estimation is significant in mobile and ubiquitous computing systems. The complexity and smaller scale of the indoor environment impose a great impact on location estimation. The key of location estimation lies in the representation and fusion of uncertain information from multiple sources. The improvement of location estimation is a complicated and comprehensive issue. A lot of research has been done to address this issue. However, existing research typically focuses on certain aspects of the problem and specific methods. This paper reviews mainstream schemes on improving indoor location estimation from multiple levels and perspectives by combining existing works and our own working experiences. Initially, we analyze the error sources of common indoor localization techniques and provide a multilayered conceptual framework of improvement schemes for location estimation. This is followed by a discussion of probabilistic methods for location estimation, including Bayes filters, Kalman filters, extended Kalman filters, sigma-point Kalman filters, particle filters, and hidden Markov models. Then, we investigate the hybrid localization methods, including multimodal fingerprinting, triangulation fusing multiple measurements, combination of wireless positioning with pedestrian dead reckoning (PDR, and cooperative localization. Next, we focus on the location determination approaches that fuse spatial contexts, namely, map matching, landmark fusion, and spatial model-aided methods. Finally, we present the directions for future research.

  18. Synthesis of Zn-Cu-Cd sulfide nanospheres with controlled copper locations and their effects on photocatalytic activities for H{sub 2} production

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Yabo; Xu, Rong [School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, Singapore 637459 (Singapore); Wang, Yongsheng [School of Mechanical and Aerospace Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798 (Singapore)

    2010-06-15

    In this work, a two-step solvothermal method was used to synthesize Zn-Cu-Cd sulfide nanospheres with controlled copper locations. The structural and other physical properties of the nanospheres were investigated by XRD, FESEM, TEM, energy-filtered TEM, XPS, ICP and UV-vis DRS methods. By varying the addition of the copper precursor during the two synthesis steps, Zn-Cu-Cd sulfide nanospheres with three distinctive copper distribution patterns can be obtained with copper (i) only in the core, (ii) only on the surface shell, and (iii) both in the core and on the surface shell. The influence of the location and concentration of copper on the photocatalytic activity for hydrogen production from water under visible light was investigated. It was found that the activity of the sample with copper only on the surface shell is about two times of that with copper only in the core. The highest hydrogen production rate was obtained on the nanosphere sample with copper both in the core and on the surface shell. The possible mechanism was discussed. The findings from this study are important for the development of efficient photocatalysts based on ternary or multinary systems. (author)

  19. NADPH oxidase complex-derived reactive oxygen species, the actin cytoskeleton, and rho GTPases in cell migration

    DEFF Research Database (Denmark)

    Stanley, Alanna; Thompson, Kerry; Hynes, Ailish

    2014-01-01

    Abstract Significance: Rho GTPases are historically known to be central regulators of actin cytoskeleton reorganization. This affects many processes including cell migration. In addition, members of the Rac subfamily are known to be involved in reactive oxygen species (ROS) production through...... mediating cytoskeletal reorganization. Critical Issues: The role of the actin cytoskeleton in providing a scaffold for components of the Nox complex needs to be examined in the light of these new advances. During cell migration, Rho GTPases, ROS, and cytoskeletal organization appear to function as a complex...... compartments. This in conjunction with the analysis of tissues lacking specific Rho GTPases, and Nox components will facilitate a detailed examination of the interactions of these structures with the actin cytoskeleton. In combination with the analysis of ROS production, including its subcellular location...

  20. Location, Location, Location: Does Place Provide the Opportunity for Differentiation for Universities?

    Science.gov (United States)

    Winter, Emma; Thompson-Whiteside, Helen

    2017-01-01

    The fiercely competitive HE market has led HEIs to invest significant resources in building a distinct identity. An HEI's location forms an inherent part of its identity and the uniqueness of location offers an opportunity to differentiate. However there has been limited examination of how location is used by HEIs and little consideration of how…

  1. High-Throughput Analysis of T-DNA Location and Structure Using Sequence Capture.

    Science.gov (United States)

    Inagaki, Soichi; Henry, Isabelle M; Lieberman, Meric C; Comai, Luca

    2015-01-01

    Agrobacterium-mediated transformation of plants with T-DNA is used both to introduce transgenes and for mutagenesis. Conventional approaches used to identify the genomic location and the structure of the inserted T-DNA are laborious and high-throughput methods using next-generation sequencing are being developed to address these problems. Here, we present a cost-effective approach that uses sequence capture targeted to the T-DNA borders to select genomic DNA fragments containing T-DNA-genome junctions, followed by Illumina sequencing to determine the location and junction structure of T-DNA insertions. Multiple probes can be mixed so that transgenic lines transformed with different T-DNA types can be processed simultaneously, using a simple, index-based pooling approach. We also developed a simple bioinformatic tool to find sequence read pairs that span the junction between the genome and T-DNA or any foreign DNA. We analyzed 29 transgenic lines of Arabidopsis thaliana, each containing inserts from 4 different T-DNA vectors. We determined the location of T-DNA insertions in 22 lines, 4 of which carried multiple insertion sites. Additionally, our analysis uncovered a high frequency of unconventional and complex T-DNA insertions, highlighting the needs for high-throughput methods for T-DNA localization and structural characterization. Transgene insertion events have to be fully characterized prior to use as commercial products. Our method greatly facilitates the first step of this characterization of transgenic plants by providing an efficient screen for the selection of promising lines.

  2. Influences of geo-spatial location on pre-exposure prophylaxis use in South Africa: positioning microbicides for better product uptake.

    Science.gov (United States)

    Govender, Eliza M; Mansoor, Leila E; Abdool Karim, Quarraisha

    2017-06-01

    Young women bear a disproportionately high burden of HIV infection in sub-Saharan Africa, prioritising pre-exposure prophylaxis (PrEP) can be an integral part of HIV prevention combination strategies. Women initiated HIV prevention technology options will require consistent adherence, an imperative for product effectiveness. With several PrEP clinical trials underway; exploring women's acceptability to advances in HIV prevention technologies can better facilitate demand creation for future PrEP roll out. This study utilised the opportunity of post-trial access to CAPRISA 008 women (trial) and non-trial women from three geo-spatial settings (urban, rural and peri-urban) to identify microbicide acceptability and how product associations of microbicides can influence future HIV prevention choices. Six participatory workshops using participatory action research with art-based activities and discussion groups were conducted in KwaZulu-Natal with 104 women from various geo-spatial locations and social status to understand microbicide acceptability and product associations. The data were analysed using thematic analysis. The study found that women's acceptability and product association of the tenofovir gel microbicide differed according to rural and urban areas. Most urban women identified confidence, sexiness and classiness as key associations that will encourage microbicide acceptability and use, while rural women identified respect, responsibility and confidence as the key product associations, with increased focus on the individual and collective family/community benefits of product acceptance and use. Urban-rural differences suggest a market segmentation that is contextualised to be locally responsive to promote HIV prevention technologies. Various sexual encounters further determined the types of HIV prevention technologies women would consider. In line with WHO's recommendation that PrEP should be an additional prevention choice for people at risk of HIV, this

  3. RNA assemblages orchestrate complex cellular processes

    DEFF Research Database (Denmark)

    Nielsen, Finn Cilius; Hansen, Heidi Theil; Christiansen, Jan

    2016-01-01

    Eukaryotic mRNAs are monocistronic, and therefore mechanisms exist that coordinate the synthesis of multiprotein complexes in order to obtain proper stoichiometry at the appropriate intracellular locations. RNA-binding proteins containing low-complexity sequences are prone to generate liquid drop...

  4. Location-aware network operation for cloud radio access network

    KAUST Repository

    Wang, Fanggang

    2017-06-20

    One of the major challenges in effectively operating a cloud radio access network (C-RAN) is the excessive overhead signaling and computation load that scale rapidly with the size of the network. In this paper, the exploitation of location information of the mobile devices is proposed to address this challenge. We consider an approach in which location-assisted channel state information (CSI) acquisition methods are introduced to complement conventional pilot-based CSI acquisition methods and avoid excessive overhead signaling. A low-complexity algorithm is designed to maximize the sum rate. An adaptive algorithm is also proposed to address the uncertainty issue in CSI acquisition. Both theoretical and numerical analyses show that location information provides a new dimension to improve throughput for next-generation massive cooperative networks.

  5. EXTRACELLULAR CELLULOLYTIC COMPLEXES PRODUCTION BY MICROSCOPIC FUNGI

    Directory of Open Access Journals (Sweden)

    S. O. Syrchin

    2015-10-01

    Full Text Available The aim of this work was to screen and to study the effect of inducers on the synthesis of the cellulolytic enzyme complexes by microscopic fungi. Cellulolytic and xylanolytic activities were determined by reducing sugar with DNS reagent, and β-glucosidase activity by pNPG hydrolysis. The enzyme preparations were obtained by ammonium sulphate precipitation. Among 32 studied strains of microscopic fungi 14 produced cellulo- and xylanolytic enzyme complexes. Fusarium sp. 5 and Fennellia sp. 2806 demonstrated the highest levels of all studied enzyme activities. Enzyme preparations with high endo-, exoglucanase, xylanase and β-glucosidase activities were obtained from these strains. Fusarium sp. 5 and Fennellia sp. 2806 were active producers of cellulase enzyme complexes during growth on natural substrates. It was shown that inductors of cellulolytic enzymes in Fusarium sp. 5 and Fennellia sp. 2806 differed from the ones in Trichoderma reesei.

  6. Clean production and design of products - Complex system and environmental politics of products

    International Nuclear Information System (INIS)

    Sanchez, M.

    1999-01-01

    The orientation of the environmental problem in sustainable terms, especially in the industrialized economies, a new profile in the last years has found. In these economies, the search of a clean production franked by a coherent politics of products and the contribution of the design of products, it have given to the environmental speech a new dimension. With the present text it is sought to respond to the necessity of exploring in Colombia this topic that has a decisive paper inside the instruments of protection of the environment cooperating to improve the quality of life in other latitudes. At the moment the theoretical foundations around the development of products play a important role in the different lines of applied investigation carried out by these countries, especially in the mark of a politics of sustainable development. In spite of the importance of this factor in the industrialized countries where the capacity of integration of a coordinated administration is of great meaning, in Colombia, particularly, the relationship between development and design of products with industry, investigation and political of development and, for our case with a clean production, it is characterized by the scarce insert and attention of this discipline

  7. 75 FR 41895 - Inteva Products, LLC Adrian, Michigan; Inteva Products, LLC Troy, Michigan; Amended Certification...

    Science.gov (United States)

    2010-07-19

    ... Products, LLC Adrian, Michigan; Inteva Products, LLC Troy, Michigan; Amended Certification Regarding... time period at the Troy, Michigan location of Inteva Products, LLC. The Troy, Michigan location.... Accordingly, the Department is amending the certification to include workers of the Troy, Michigan location of...

  8. Cationic Amphiphilic Tris-Cyclometalated Iridium(III) Complexes Induce Cancer Cell Death via Interaction with Ca2+-Calmodulin Complex.

    Science.gov (United States)

    Hisamatsu, Yosuke; Suzuki, Nozomi; Masum, Abdullah-Al; Shibuya, Ai; Abe, Ryo; Sato, Akira; Tanuma, Sei-Ichi; Aoki, Shin

    2017-02-15

    In our previous paper, we reported on the preparation of some cationic amphiphilic Ir complexes (2c, 2d) containing KKGG peptides that induce and detect cell death of Jurkat cells. Mechanistic studies suggest that 2c interacts with anionic molecules and/or membrane receptors on the cell surface to trigger an intracellular Ca 2+ response, resulting in the induction of cell death, accompanied by membrane disruption. We have continued the studies of cell death of Jurkat cells induced by 2c and found that xestospongin C, a selective inhibitor of an inositol 1,4,5-trisphosphate receptor located on the endoplasmic reticulum (ER), reduces the cytotoxicity of 2c, suggesting that 2c triggers the release of Ca 2+ from the ER, leading to an increase in the concentration of cytosolic Ca 2+ , thus inducing cell death. Moreover, we synthesized a series of new amphiphilic cationic Ir complexes 5a-c containing photoreactive 3-trifluoromethyl-3-phenyldiazirine (TFPD) groups, in an attempt to identify the target molecules of 2c. Interestingly, it was discovered that a TFPD group functions as a triplet quencher of Ir complexes. It was also found that 5b is useful as a turn-on phosphorescent probe of acidic proteins such as bovine serum albumin (BSA) (pI = 4.7) and their complexation was confirmed by luminescence titrations and SDS-PAGE of photochemical products between them. These successful results allowed us to carry out photoaffinity labeling of the target biomolecules of 5b (2c and analogues thereof) in Jurkat cells. A proteomic analysis of the products obtained by the photoirradiation of 5b with Jurkat cells suggests that the Ca 2+ -binding protein "calmodulin (CaM)" is one of target proteins of the Ir complexes. Indeed, 5b was found to interact with the Ca 2+ -CaM complex, as evidenced by luminescence titrations and the results of photochemical reactions of 5b with CaM in the presence of Ca 2+ (SDS-PAGE). A plausible mechanism for cell death induced by a cationic amphiphilic Ir

  9. Collaborative engineering for complex products

    CSIR Research Space (South Africa)

    Erasmus, J

    2015-10-01

    Full Text Available stream_source_info Erasmus_2015.pdf.txt stream_content_type text/plain stream_size 6206 Content-Encoding UTF-8 stream_name Erasmus_2015.pdf.txt Content-Type text/plain; charset=UTF-8 Collaborative engineering... with collaboration and cooperation • Now they compete on implementation (application) instead of standards (infrastructure) Reyes, V., 2014. Dealing with automotive software complexity with virtual prototyping – Part 1: Virtual HIL development basics (accessed 9...

  10. Profiling of high-frequency accident locations by use of association rules

    OpenAIRE

    GEURTS, Karolien; WETS, Geert; BRIJS, Tom; VANHOOF, Koen

    2003-01-01

    In Belgium, traffic safety is one of the government's highest priorities. The identification and profiling of black spots and black zones (geographical locations with high concentrations of traffic accidents) in terms of accident-related data and location characteristics must provide new insights into the complexity and causes of road accidents, which, in turn, provide valuable input for governmental actions. Association rules were used to identify accident-related circumstances that frequent...

  11. Police Spatial Big Data Location Code and Its Application Prospect

    Directory of Open Access Journals (Sweden)

    HU Xiaoguang

    2016-12-01

    Full Text Available The rich decision-making basis are provided for police work by police spatial big data. But some challenges are also brought by it, such as:large data integration complex, multi scale information related difficulties, the location identification is not unique. Thus, how to make the data better service to the police work reform and development is a problem need to be study. In this paper, we propose location identification method to solve the existing problems. Based on subdivision grid, we design the location encoding method of police spatial big data, and choose domicile location identification as a case. Finally, the prospect of its application is presented. So, a new idea is proposed to solve the problem existing in the police spatial data organization and application.

  12. The Development of Narrative Productivity, Syntactic Complexity, Referential Cohesion and Event Content in Four- to Eight-Year-Old Finnish Children

    Science.gov (United States)

    Mäkinen, Leena; Loukusa, Soile; Nieminen, Lea; Leinonen, Eeva; Kunnari, Sari

    2014-01-01

    This study focuses on the development of narrative structure and the relationship between narrative productivity and event content. A total of 172 Finnish children aged between four and eight participated. Their picture-elicited narrations were analysed for productivity, syntactic complexity, referential cohesion and event content. Each measure…

  13. Novel product ions of 2-aminoanilide and benzimidazole Ag(I) complexes using electrospray ionization with multi-stage tandem mass spectrometry.

    Science.gov (United States)

    Johnson, Byron S; Burinsky, David J; Burova, Svetlana A; Davis, Roman; Fitzgerald, Russ N; Matsuoka, Richard T

    2012-05-15

    The 2-aminoaniline scaffold is of significant value to the pharmaceutical industry and is embedded in a number of pharmacophores including 2-aminoanilides and benzimidazoles. A novel application of coordination ion spray mass spectrometry (CIS-MS) for interrogating the silver ion (Ag(+)) complexes of a homologous series of these compounds using multi-stage tandem mass spectrometry is described. Unlike the ubiquitous alkali metal ion complexes, Ag(+) complexes of 2-aminoanilides and benzimidazoles were found to yield [M - H](+) ions in significant abundance via gas-phase elimination of the metal hydride (AgH) resulting in unique product ion cascades. Sample introduction was by liquid chromatography with mass spectrometry analysis performed on a hybrid linear ion trap/orbitrap instrument capable of high-resolution measurements. Rigorous structural characterization by multi-stage tandem mass spectrometry using [M +  H](+), [M - H](-) and [M - H](+) precursor ions derived from ESI and CIS experiments was performed for the homologous series of 2-aminoanilide and benzimidazole compounds. A full tabular comparison of structural information resulting from these product ion cascades was produced. Multi-stage tandem mass spectrometry of [M - H](+) ions resulting from Ag(+) complexes of 2-aminoanilides and benzimidazoles in CIS-MS experiments produced unique product ion cascades that exhibited complementary structural information to that obtained from tandem mass spectrometry of [M  +  H](+) and [M - H](-) ions by electrospray ionization (ESI). These observations may be broadly applicable to other compounds that are observed to form Ag(+) complexes and eliminate AgH. Copyright © 2012 John Wiley & Sons, Ltd.

  14. The logic, experimental steps, and potential of heterologous natural product biosynthesis featuring the complex antibiotic erythromycin A produced through E. coli.

    Science.gov (United States)

    Jiang, Ming; Zhang, Haoran; Pfeifer, Blaine A

    2013-01-13

    The heterologous production of complex natural products is an approach designed to address current limitations and future possibilities. It is particularly useful for those compounds which possess therapeutic value but cannot be sufficiently produced or would benefit from an improved form of production. The experimental procedures involved can be subdivided into three components: 1) genetic transfer; 2) heterologous reconstitution; and 3) product analysis. Each experimental component is under continual optimization to meet the challenges and anticipate the opportunities associated with this emerging approach. Heterologous biosynthesis begins with the identification of a genetic sequence responsible for a valuable natural product. Transferring this sequence to a heterologous host is complicated by the biosynthetic pathway complexity responsible for product formation. The antibiotic erythromycin A is a good example. Twenty genes (totaling >50 kb) are required for eventual biosynthesis. In addition, three of these genes encode megasynthases, multi-domain enzymes each ~300 kDa in size. This genetic material must be designed and transferred to E. coli for reconstituted biosynthesis. The use of PCR isolation, operon construction, multi-cystronic plasmids, and electro-transformation will be described in transferring the erythromycin A genetic cluster to E. coli. Once transferred, the E. coli cell must support eventual biosynthesis. This process is also challenging given the substantial differences between E. coli and most original hosts responsible for complex natural product formation. The cell must provide necessary substrates to support biosynthesis and coordinately express the transferred genetic cluster to produce active enzymes. In the case of erythromycin A, the E. coli cell had to be engineered to provide the two precursors (propionyl-CoA and (2S)-methylmalonyl-CoA) required for biosynthesis. In addition, gene sequence modifications, plasmid copy number

  15. Economic interdependence and complexity: Falaj agriculture and ceramic production in the southeast Arabian iron age

    International Nuclear Information System (INIS)

    Magee, P.

    1997-01-01

    Over the last fifteen years surveys and excavations in the United Arab Emirates and Sultanate of Oman have revealed a widespread and distinctive material culture dating to the late second and first millennium BC. In this paper the results of PIXE-PIGME analysis of ceramics from the Iron II period (1100-600 BC) are presented. In combination with ceramic distribution data, the analysis permits the identification of ceramic production areas. More importantly, however, the analysis, when combined with environmental and subsistence strategy data, provides an insight into the relationship between agricultural intensification and ceramic production and the varying degrees of economic complexity which existed at this time

  16. Block-induced Complex Structures Building the Flare-productive Solar Active Region 12673

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Shuhong; Zhang, Jun [CAS Key Laboratory of Solar Activity, National Astronomical Observatories, Chinese Academy of Sciences, Beijing 100012 (China); Zhu, Xiaoshuai [Max-Planck Institute for Solar System Research, D-37077 Göttingen (Germany); Song, Qiao, E-mail: shuhongyang@nao.cas.cn [Key Laboratory of Space Weather, National Center for Space Weather, China Meteorological Administration, Beijing 100081 (China)

    2017-11-10

    Solar active region (AR) 12673 produced 4 X-class, 27 M-class, and numerous lower-class flares during its passage across the visible solar disk in 2017 September. Our study is to answer the questions why this AR was so flare-productive and how the X9.3 flare, the largest one of the past decade, took place. We find that there was a sunspot in the initial several days, and then two bipolar regions emerged nearby it successively. Due to the standing of the pre-existing sunspot, the movement of the bipoles was blocked, while the pre-existing sunspot maintained its quasi-circular shaped umbra only with the disappearance of a part of penumbra. Thus, the bipolar patches were significantly distorted, and the opposite polarities formed two semi-circular shaped structures. After that, two sequences of new bipolar regions emerged within the narrow semi-circular zone, and the bipolar patches separated along the curved channel. The new bipoles sheared and interacted with the previous ones, forming a complex topological system, during which numerous flares occurred. At the highly sheared region, a great deal of free energy was accumulated. On September 6, one negative patch near the polarity inversion line began to rapidly rotate and shear with the surrounding positive fields, and consequently the X9.3 flare erupted. Our results reveal that the block-induced complex structures built the flare-productive AR and the X9.3 flare was triggered by an erupting filament due to the kink instability. To better illustrate this process, a block-induced eruption model is proposed for the first time.

  17. A complex approach on integrated late bilinguals’ English VOT production: a study on south Brazilian immigrants in London

    Directory of Open Access Journals (Sweden)

    Felipe Flores Kupske

    2017-09-01

    Full Text Available Departing from a Complex perspective to language, this study explores the correlation between length of residence (LOR in London and the production of word-initial English voiceless stops by late south Brazilian bilinguals who have an integrative motivation towards the host language and culture. To this end, 12 immigrants are compared to 10 standard southern British English monolinguals. Acoustic analysis of VOT duration is reported. The results demonstrated that the immigrants’ VOT values for English increased along with LOR. The bilinguals with the longest LOR revealed a production of English VOT within the range expected for the controls. These findings can be interpreted as evidence for language as a Complex Adaptive System, and for the hypothesis that the neuroplasticity and the cognitive mechanisms for language development remain intact during the lifespan.

  18. The Effects of Verb Argument Complexity on Verb Production in Persons with Aphasia: Evidence from a Subject-Object-Verb Language

    Science.gov (United States)

    Sung, Jee Eun

    2016-01-01

    The purpose of the study was to investigate the effects of verb argument complexity on verb production in individuals with aphasia using a verb-final language. The verb-argument complexity was examined by the number of arguments (1-, 2-, and 3-place) and the types of arguments (unaccusative vs. unergative comparisons). Fifteen Korean-speaking…

  19. Contracting for Complex Products

    Science.gov (United States)

    2010-05-01

    asymmetries, and barriers to market entry and exit (e.g., Mankiw , et al., 2002). Goods may be non-rivalrous or non-excludable so that transferable property...investments. Expenditures are asset specific to the extent they have no economic value outside the product being produced (Williamson, 2005). For...example, some research in the US space program produced economic value outside the contract (e.g., Tang), while other research produced little value

  20. Bees do not use nearest-neighbour rules for optimization of multi-location routes.

    Science.gov (United States)

    Lihoreau, Mathieu; Chittka, Lars; Le Comber, Steven C; Raine, Nigel E

    2012-02-23

    Animals collecting patchily distributed resources are faced with complex multi-location routing problems. Rather than comparing all possible routes, they often find reasonably short solutions by simply moving to the nearest unvisited resources when foraging. Here, we report the travel optimization performance of bumble-bees (Bombus terrestris) foraging in a flight cage containing six artificial flowers arranged such that movements between nearest-neighbour locations would lead to a long suboptimal route. After extensive training (80 foraging bouts and at least 640 flower visits), bees reduced their flight distances and prioritized shortest possible routes, while almost never following nearest-neighbour solutions. We discuss possible strategies used during the establishment of stable multi-location routes (or traplines), and how these could allow bees and other animals to solve complex routing problems through experience, without necessarily requiring a sophisticated cognitive representation of space.

  1. The frequency of down's syndrome in the city of Ozyorsk located near the nuclear complex ''Mayak''

    Energy Technology Data Exchange (ETDEWEB)

    Petrushkina, N.P.; Okatenko, P.V.; Kabirova, N.R.; Koshurnikova, N.A. [Branch No 1 of the State Research Center, Ozyorsk (Russian Federation). Biophysics Inst.

    2000-05-01

    The aim of the study is to assess the frequency of Down's syndrome (DS) among newborns in the city of Ozyorsk located near the nuclear complex Mayak''. The study has been conducted on the basis of the cohort, which includes 18,499 children born in Ozyorsk in 1974-1988. Information on cases of DS has been abstracted from newborn records at the city maternity hospital. The frequency of DS in Ozyorsk is 1.4 cases per 1,000 newborns. According to some published data, the population frequency of this syndrome is 1.25-1.42 cases per 1,000 newborns. The frequency of DS among children whose parents were occupationally exposed to radiation has been studied. The cohort has been divided into two subcohorts based on whether or not parents worked at Mayak. In 5,303 children either one or both parents worked at Mayak. The comparison group includes 13,196 children whose parents never worked at Mayak. In the children, whose parents worked at Mayak, the frequency of DS is 1.32 cases per 1000, and in the comparison group - 1.44 cases per 1000 (the difference is not statistically significant). Parental radiation doses by the time of conception of children with DS are in the range from 0.65 to 10.31 cSv. Our data confirm the effect of maternal age on the frequency of DS. The frequency of DS in children born to mother under the age of 30 is 0.94 per 1,000 and in children born to mothers older than 30 years - 3.87 per 1,000. So the frequency of DS among children born in the city located near the nuclear complex does not exceed the spontaneous level. No association has been detected between the frequency of DS and preconception parental radiation exposure. The effect of maternal age has been confirmed. (author)

  2. Selection of adequate site location during early stages of construction project management: A multi-criteria decision analysis approach

    Science.gov (United States)

    Marović, Ivan; Hanak, Tomaš

    2017-10-01

    In the management of construction projects special attention should be given to the planning as the most important phase of decision-making process. Quality decision-making based on adequate and comprehensive collaboration of all involved stakeholders is crucial in project’s early stages. Fundamental reasons for existence of this problem arise from: specific conditions of construction industry (final products are inseparable from the location i.e. location has a strong influence of building design and its structural characteristics as well as technology which will be used during construction), investors’ desires and attitudes, and influence of socioeconomic and environment aspects. Considering all mentioned reasons one can conclude that selection of adequate construction site location for future investment is complex, low structured and multi-criteria problem. To take into account all the dimensions, the proposed model for selection of adequate site location is devised. The model is based on AHP (for designing the decision-making hierarchy) and PROMETHEE (for pairwise comparison of investment locations) methods. As a result of mixing basis feature of both methods, operational synergies can be achieved in multi-criteria decision analysis. Such gives the decision-maker a sense of assurance, knowing that if the procedure proposed by the presented model has been followed, it will lead to a rational decision, carefully and systematically thought out.

  3. Desires for beverages and liking of skin care product odors in imaginative and immersive virtual reality beach contexts

    DEFF Research Database (Denmark)

    Andersen, Ida Ninett Skovgaard K; Kraus, Alexandra A.; Ritz, Christian

    2018-01-01

    Immersive technologies simulating real-life environments allow repeated simulation of complex real-life situations at one location and, therefore, bear potential for consumer product evaluations and food behavior studies. This study aimed to assess whether a contextual exposure by immersive virtu...... on beverage-related desires. The VR technology seems to be a promising tool for evaluating contextual influences in food consumer research.......Immersive technologies simulating real-life environments allow repeated simulation of complex real-life situations at one location and, therefore, bear potential for consumer product evaluations and food behavior studies. This study aimed to assess whether a contextual exposure by immersive virtual...... in the same room but without the contextual exposure was also performed (Neutral). Subjects rated their desires for hot and cold beverages during and just after the contextual exposure. Liking for skin care samples (sun screen and regular lotion) were assessed during exposure. The retention of the contextual...

  4. Neighbourhood Acceptability of Poultry Farms Located in ...

    African Journals Online (AJOL)

    ... due to poultry production in their neighbourhood. It was recommended that farmers should be encouraged to adopt technologies that can keep poultry litters dry and odourless. In addition, poultry farm locations should be sited far away from residential areas. Keywords: Poultry Farms, Acceptability, Waste management, ...

  5. Modeling the Variable Heliopause Location

    Science.gov (United States)

    Hensley, Kerry

    2018-03-01

    1 crossed the heliopause. The current location of Voyager 2 is marked with a red circle. [Washimi et al. 2017]A Time-Varying BarrierThe authorsconsider the impact that solar flares, coronal mass ejections, and other disturbances in the solar outflow have on the heliopause distance. These solar disturbances intermingle as they travel outward to form what the authors call global merged interaction regions.Using their hydrodynamical simulations, Washimi and collaborators capture the complex behavior of the global merged interaction regions as they propagate through the termination shock and collide with the heliopause. Part of the shock is transmitted into the local interstellar medium, while part of it is reflected back toward and collides with the termination shock, which is pushed toward the Sun. This complex interplay of transmitted and reflected shocks combined with the nonuniformity of the local interstellar medium causes the heliopause location to vary dramatically in time as well as space.What Does this Mean for Voyager 2?Washimi and collaborators find that the location of the heliopause along the trajectories of Voyagers 1 and 2 has changed considerably over the past decade. In particular, they find that the heliopause has been pushed outward over the past few years due to an increase in the solar wind ram pressure. According to their simulations, Voyager 2 is currently traveling outward faster than the heliopause is advancing, which means that the spacecraft should soon cross the boundary perhaps even thisyear to become Earths second interstellar messenger.CitationHaruichi Washimi et al 2017 ApJL 846 L9. doi:10.3847/2041-8213/aa8556

  6. Conceptualising health services in terms of level and location of care

    African Journals Online (AJOL)

    location of care, are complex combinations of services. They encompass all levels of care ... expression in the recently published ANC health plan. This more comprehensive ..... business of training PHC providers and basic specialists as.

  7. Joint Optimal Production Planning for Complex Supply Chains Constrained by Carbon Emission Abatement Policies

    OpenAIRE

    He, Longfei; Xu, Zhaoguang; Niu, Zhanwen

    2014-01-01

    We focus on the joint production planning of complex supply chains facing stochastic demands and being constrained by carbon emission reduction policies. We pick two typical carbon emission reduction policies to research how emission regulation influences the profit and carbon footprint of a typical supply chain. We use the input-output model to capture the interrelated demand link between an arbitrary pair of two nodes in scenarios without or with carbon emission constraints. We design optim...

  8. Identification of complexity cost factors in manufacturing companies

    DEFF Research Database (Denmark)

    Myrodia, Anna; Hvam, Lars

    2015-01-01

    Complexity tends to be arguably the biggest challenge of manufacturing companies. As the demand from the customers increases in volume and diversity, the number of finished products and components increases as well. This increasing product complexity has a direct effect on the production processes....... This research focuses on the relation between product and process complexity. Complexity cost factors are identified and categorized under the industrial standard APQC for process classification. Then, this categorization is used as a tool for identification of complexity cost factors in seven companies...

  9. SOLID WASTE MANAGEMENT IN TABRIZ PETROCHEMICAL COMPLEX

    Directory of Open Access Journals (Sweden)

    M. A. Abduli, M. Abbasi, T. Nasrabadi, H. Hoveidi, N. Razmkhah

    2006-07-01

    Full Text Available Tabriz petrochemical complex is located in the northwest of Iran. Major products of this industry include raw plastics like, polyethylene, polystyrene, acrylonitrile, butadiene, styrene, etc. Sources of waste generation include service units, health and cure units, water, power, steam and industrial processes units. In this study, different types of solid waste including hazardous and non hazardous solid wastes were investigated separately. The aim of the study was to focus on the management of the industrial wastes in order to minimize the adverse environmental impacts. In the first stage, locating map and dispersion limits were prepared. Then, the types and amounts of industrial waste generated in were evaluated by an inventory and inspection. Wastes were classified according to Environmental Protection Agency and Basel Standards and subsequently hazards of different types were investigated. The waste management of TPC is quite complex because of the different types of waste and their pollution. In some cases recycling/reuse of waste is the best option, but treatment and disposal are also necessary tools. In this study, using different sources and references, generally petrochemical sources, various solid waste management practices were investigated and the best options were selected. Some wastes should be treated before land filling and some of them should be reused or recycled. In the case of solid waste optimization, source reduction ways were recommended as well as prior incineration system was modified.

  10. Recommender systems for location-based social networks

    CERN Document Server

    Symeonidis, Panagiotis; Manolopoulos, Yannis

    2014-01-01

    Online social networks collect information from users' social contacts and their daily interactions (co-tagging of photos, co-rating of products etc.) to provide them with recommendations of new products or friends. Lately, technological progressions in mobile devices (i.e. smart phones) enabled the incorporation of geo-location data in the traditional web-based online social networks, bringing the new era of Social and Mobile Web. The goal of this book is to bring together important research in a new family of recommender systems aimed at serving Location-based Social Networks (LBSNs). The chapters introduce a wide variety of recent approaches, from the most basic to the state-of-the-art, for providing recommendations in LBSNs. The book is organized into three parts. Part 1 provides introductory material on recommender systems, online social networks and LBSNs. Part 2 presents a wide variety of recommendation algorithms, ranging from basic to cutting edge, as well as a comparison of the characteristics of t...

  11. Bcs1p can rescue a large and productive cytochrome bc(1) complex assembly intermediate in the inner membrane of yeast mitochondria.

    Science.gov (United States)

    Conte, Laura; Trumpower, Bernard L; Zara, Vincenzo

    2011-01-01

    The yeast cytochrome bc(1) complex, a component of the mitochondrial respiratory chain, is composed of ten distinct protein subunits. In the assembly of the bc(1) complex, some ancillary proteins, such as the chaperone Bcs1p, are actively involved. The deletion of the nuclear gene encoding this chaperone caused the arrest of the bc(1) assembly and the formation of a functionally inactive bc(1) core structure of about 500-kDa. This immature bc(1) core structure could represent, on the one hand, a true assembly intermediate or, on the other hand, a degradation product and/or an incorrect product of assembly. The experiments here reported show that the gradual expression of Bcs1p in the yeast strain lacking this protein was progressively able to rescue the bc(1) core structure leading to the formation of the functional homodimeric bc(1) complex. Following Bcs1p expression, the mature bc(1) complex was also progressively converted into two supercomplexes with the cytochrome c oxidase complex. The capability of restoring the bc(1) complex and the supercomplexes was also possessed by the mutated yeast R81C Bcsp1. Notably, in the human ortholog BCS1L, the corresponding point mutation (R45C) was instead the cause of a severe bc(1) complex deficiency. Differently from the yeast R81C Bcs1p, two other mutated Bcs1p's (K192P and F401I) were unable to recover the bc(1) core structure in yeast. This study identifies for the first time a productive assembly intermediate of the yeast bc(1) complex and gives new insights into the molecular mechanisms involved in the last steps of bc(1) assembly. Copyright © 2010 Elsevier B.V. All rights reserved.

  12. Agglomeration, accessibility and industrial location: evidence from spanish municipalities

    OpenAIRE

    Alañón Pardo, Ángel; Arauzo Carod, Josep María

    2011-01-01

    This paper deals with the location decisions of manufacturing firms in Spain. We analyse how agglomeration economies and transport accessibility influence the location decisions of firms at municipality level and in three industries. The main empirical contributions of this paper are the econometric techniques used (spatial econometric models) and some of the explanatory variables (local gross domestic product, road accessibility, and the characteristics of firms in neighbouring municipalitie...

  13. Expectation-Maximization Tensor Factorization for Practical Location Privacy Attacks

    Directory of Open Access Journals (Sweden)

    Murakami Takao

    2017-10-01

    Full Text Available Location privacy attacks based on a Markov chain model have been widely studied to de-anonymize or de-obfuscate mobility traces. An adversary can perform various kinds of location privacy attacks using a personalized transition matrix, which is trained for each target user. However, the amount of training data available to the adversary can be very small, since many users do not disclose much location information in their daily lives. In addition, many locations can be missing from the training traces, since many users do not disclose their locations continuously but rather sporadically. In this paper, we show that the Markov chain model can be a threat even in this realistic situation. Specifically, we focus on a training phase (i.e. mobility profile building phase and propose Expectation-Maximization Tensor Factorization (EMTF, which alternates between computing a distribution of missing locations (E-step and computing personalized transition matrices via tensor factorization (M-step. Since the time complexity of EMTF is exponential in the number of missing locations, we propose two approximate learning methods, one of which uses the Viterbi algorithm while the other uses the Forward Filtering Backward Sampling (FFBS algorithm. We apply our learning methods to a de-anonymization attack and a localization attack, and evaluate them using three real datasets. The results show that our learning methods significantly outperform a random guess, even when there is only one training trace composed of 10 locations per user, and each location is missing with probability 80% (i.e. even when users hardly disclose two temporally-continuous locations.

  14. Effective algorithm for solving complex problems of production control and of material flows control of industrial enterprise

    Science.gov (United States)

    Mezentsev, Yu A.; Baranova, N. V.

    2018-05-01

    A universal economical and mathematical model designed for determination of optimal strategies for managing subsystems (components of subsystems) of production and logistics of enterprises is considered. Declared universality allows taking into account on the system level both production components, including limitations on the ways of converting raw materials and components into sold goods, as well as resource and logical restrictions on input and output material flows. The presented model and generated control problems are developed within the framework of the unified approach that allows one to implement logical conditions of any complexity and to define corresponding formal optimization tasks. Conceptual meaning of used criteria and limitations are explained. The belonging of the generated tasks of the mixed programming with the class of NP is shown. An approximate polynomial algorithm for solving the posed optimization tasks for mixed programming of real dimension with high computational complexity is proposed. Results of testing the algorithm on the tasks in a wide range of dimensions are presented.

  15. Life cycle water demand coefficients for crude oil production from five North American locations.

    Science.gov (United States)

    Ali, Babkir; Kumar, Amit

    2017-10-15

    The production of liquid fuels from crude oil requires water. There has been limited focus on the assessment of life cycle water demand footprints for crude oil production and refining. The overall aim of this paper is address this gap. The objective of this research is to develop water demand coefficients over the life cycle of fuels produced from crude oil pathways. Five crude oil fields were selected in the three North American countries to reflect the impact of different spatial locations and technologies on water demand. These include the Alaska North Slope, California's Kern County heavy oil, and Mars in the U.S.; Maya in Mexico; and Bow River heavy oil in Alberta, Canada. A boundary for an assessment of the life cycle water footprint was set to cover the unit operations related to exploration, drilling, extraction, and refining. The recovery technology used to extract crude oil is one of the key determining factors for water demand. The amount of produced water that is re-injected to recover the oil is essential in determining the amount of fresh water that will be required. During the complete life cycle of one barrel of conventional crude oil, 1.71-8.25 barrels of fresh water are consumed and 2.4-9.51 barrels of fresh water are withdrawn. The lowest coefficients are for Bow River heavy oil and the highest coefficients are for Maya crude oil. Of all the unit operations, exploration and drilling require the least fresh water (less than 0.015 barrel of water per barrel of oil produced). A sensitivity analysis was conducted and uncertainty in the estimates was determined. Copyright © 2017 Elsevier Ltd. All rights reserved.

  16. Use and validity of principles of extremum of entropy production in the study of complex systems

    International Nuclear Information System (INIS)

    Heitor Reis, A.

    2014-01-01

    It is shown how both the principles of extremum of entropy production, which are often used in the study of complex systems, follow from the maximization of overall system conductivities, under appropriate constraints. In this way, the maximum rate of entropy production (MEP) occurs when all the forces in the system are kept constant. On the other hand, the minimum rate of entropy production (mEP) occurs when all the currents that cross the system are kept constant. A brief discussion on the validity of the application of the mEP and MEP principles in several cases, and in particular to the Earth’s climate is also presented. -- Highlights: •The principles of extremum of entropy production are not first principles. •They result from the maximization of conductivities under appropriate constraints. •The conditions of their validity are set explicitly. •Some long-standing controversies are discussed and clarified

  17. 16 CFR Figure 3 to Part 1203 - Location of Reference Plane

    Science.gov (United States)

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false Location of Reference Plane 3 Figure 3 to Part 1203 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION CONSUMER PRODUCT SAFETY ACT... Plane ER10MR98.003 ...

  18. Location of gene expression in CNS using hybridization histochemistry

    International Nuclear Information System (INIS)

    Penschow, J.D.; Haralambidis, J.; Aldred, P.; Tregear, G.W.; Coghlan, J.P.

    1986-01-01

    The pursuit of improvements in sensitivity, specificity, and resolution has resulted in a myriad of published procedures designed for a variety of applications and of seemingly increasing complexity. The choice of technique now available, through significant recent technological advances, includes nonisotopic cDNA probe labels, single-stranded RNA (Riboprobe), and synthetic oligonucleotides as probes, in addition to the now familiar radiolabeled cDNA probes. The authors' aim is to simplify this choice by describing a convenient method applicable to the location of specific mRNA in brain and other tissues by either cDNA or synthetic oligodeoxyribonucleotide probes. The procedure is based on a /sup 32/P probe label which enables detection of the mRNA-DNA hybrids on X-ray fail autoradiographs of frozen sections within 48 hr of tissue collection. Single, labeled cells can be located in heterogeneous tissues in subsequent short exposure liquid emulsion autoradiographs. This technique has been used successfully over a period of 5 years on tissues as diverse as whole small animals, sheep brain, rat thyroid, and human tumors. Deproteination procedures employed with other methods, which have been found to be unnecessary for /sup 32/P, are not included, thus simplifying the procedure. The use of synthetic oligodeoxyribonucleotides is emphasized as their choice of probes for the reasons outlined. Apart from providing an escape route from dependence on a molecular biology laboratory, discriminating sequences of similar gene products can be synthesized and localized so that single cells within small groups can be further characterized by their biosynthetic function

  19. Understanding Complex Construction Systems Through Modularity

    DEFF Research Database (Denmark)

    Jensen, Tor Clarke; Bekdik, Baris; Thuesen, Christian

    2014-01-01

    This paper develops a framework for understanding complexity in construction projects by combining theories of complexity management and modularization. The framework incorporates three dimensions of product, process, and organizational modularity with the case of gypsum wall elements. The analysis...... system, rather than a modular, although the industry forces modular organizational structures. This creates a high complexity degree caused by the non-alignment of building parts and organizations and the frequent swapping of modules....... finds that the main driver of complexity is the fragmentation of the design and production, which causes the production modules to construct and install new product types and variants for each project as the designers are swapped for every project. The many interfaces are characteristics of an integral...

  20. Controlling Magnetism of a Complex Metallic System Using Atomic Individualism

    Science.gov (United States)

    Mudryk, Y.; Paudyal, D.; Pecharsky, V. K.; Gschneidner, K. A., Jr.; Misra, S.; Miller, G. J.

    2010-08-01

    When the complexity of a metallic compound reaches a certain level, a specific location in the structure may be critically responsible for a given fundamental property of a material while other locations may not play as much of a role in determining such a property. The first-principles theory has pinpointed a critical location in the framework of a complex intermetallic compound—Gd5Ge4—that resulted in a controlled alteration of the magnetism of this compound using precise chemical tools.

  1. Virtual Solar Energy Center: A Case Study of the Use of Advanced Visualization Techniques for the Comprehension of Complex Engineering Products and Processes

    Science.gov (United States)

    Ritter, Kenneth August, III

    Industry has a continuing need to train its workforce on recent engineering developments, but many engineering products and processes are hard to explain because of limitations of size, visibility, time scale, cost, and safety. The product or process might be difficult to see because it is either very large or very small, because it is enclosed within an opaque container, or because it happens very fast or very slowly. Some engineering products and processes are also costly or unsafe to use for training purposes, and sometimes the domain expert is not physically available at the training location. All these limitations can potentially be addressed using advanced visualization techniques such as virtual reality. This dissertation describes the development of an immersive virtual reality application using the Six Sigma DMADV process to explain the main equipment and processes used in a concentrating solar power plant. The virtual solar energy center (VEC) application was initially developed and tested in a Cave Automatic Virtual Environment (CAVE) during 2013 and 2014. The software programs used for development were SolidWorks, 3ds Max Design, and Unity 3D. Current hardware and software technologies that could complement this research were analyzed. The NVIDA GRID Visual Computing Appliance (VCA) was chosen as the rendering solution for animating complex CAD models in this application. The MiddleVR software toolkit was selected as the toolkit for VR interactions and CAVE display. A non-immersive 3D version of the VEC application was tested and shown to be an effective training tool in late 2015. An immersive networked version of the VEC allows the user to receive live instruction from a trainer being projected via depth camera imagery from a remote location. Four comparative analysis studies were performed. These studies used the average normalized gain from pre-test scores to determine the effectiveness of the various training methods. With the DMADV approach

  2. Priority Directions of The Regional Food Complex Effectiveness Increase

    Directory of Open Access Journals (Sweden)

    Dmitry Andreyevich Karkh

    2015-06-01

    Full Text Available In the article, the modern trends of management integration as a solution of food and sectoral problems are considered. On the basis of national and foreign experience of development of integration, the classification of integration in economic systems is developed. On the basis of the given classification, the concept of integration is conducted. In the article, much attention is given to the food problem solution, which depends more on the agro-industrial complex based on metaintegration. The leading place of a food complex in the system of agro-industrial complex is caused by a role of food and food raw materials in life of the population of the country. The ratio of the sectors participating in the food production and consumer goods makes the sectoral structure of agro-industrial complex. In the conditions of the resource limitation necessary for the production and food delivery to the domestic market, the role of trade will increase not only in agro-industrial complex, but in all national economy. Also, in this article, the phenomenon of clusters is studied. The attention to clusters as to innovation systems reflects a rising tide of interest of economic science to the questions of economics functioning in regional level and understanding of a role of specific local resources in stimulation of innovative opportunities and competitiveness of small and medium business. Creating a cluster, participants develop the spatial and organizational integrated structure, in interaction of legal entities the status is saved and cooperation provides competitive advantages with other business entities. The role of the state in integration of cluster formations in the Russian Federation is more significant, than in any other country. The state represented by regional authorities actively participates in decision-making process by the business located in its catchment area not only through membership in governing bodies of large joint stock companies.

  3. Design Analysis Method for Multidisciplinary Complex Product using SysML

    Directory of Open Access Journals (Sweden)

    Liu Jihong

    2017-01-01

    Full Text Available In the design of multidisciplinary complex products, model-based systems engineering methods are widely used. However, the methodologies only contain only modeling order and simple analysis steps, and lack integrated design analysis methods supporting the whole process. In order to solve the problem, a conceptual design analysis method with integrating modern design methods has been proposed. First, based on the requirement analysis of the quantization matrix, the user’s needs are quantitatively evaluated and translated to system requirements. Then, by the function decomposition of the function knowledge base, the total function is semi-automatically decomposed into the predefined atomic function. The function is matched into predefined structure through the behaviour layer using function-structure mapping based on the interface matching. Finally based on design structure matrix (DSM, the structure reorganization is completed. The process of analysis is implemented with SysML, and illustrated through an aircraft air conditioning system for the system validation.

  4. Complex Regulatory Networks Governing Production of the Glycopeptide A40926

    Directory of Open Access Journals (Sweden)

    Rosa Alduina

    2018-04-01

    Full Text Available Glycopeptides (GPAs are an important class of antibiotics, with vancomycin and teicoplanin being used in the last 40 years as drugs of last resort to treat infections caused by Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus. A few new GPAs have since reached the market. One of them is dalbavancin, a derivative of A40926 produced by the actinomycete Nonomuraea sp. ATCC 39727, recently classified as N. gerenzanensis. This review summarizes what we currently know on the multilevel regulatory processes governing production of the glycopeptide A40926 and the different approaches used to increase antibiotic yields. Some nutrients, e.g., valine, l-glutamine and maltodextrin, and some endogenous proteins, e.g., Dbv3, Dbv4 and RpoBR, have a positive role on A40926 biosynthesis, while other factors, e.g., phosphate, ammonium and Dbv23, have a negative effect. Overall, the results available so far point to a complex regulatory network controlling A40926 in the native producing strain.

  5. Complex Regulatory Networks Governing Production of the Glycopeptide A40926.

    Science.gov (United States)

    Alduina, Rosa; Sosio, Margherita; Donadio, Stefano

    2018-04-05

    Glycopeptides (GPAs) are an important class of antibiotics, with vancomycin and teicoplanin being used in the last 40 years as drugs of last resort to treat infections caused by Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus . A few new GPAs have since reached the market. One of them is dalbavancin, a derivative of A40926 produced by the actinomycete Nonomuraea sp. ATCC 39727, recently classified as N. gerenzanensis . This review summarizes what we currently know on the multilevel regulatory processes governing production of the glycopeptide A40926 and the different approaches used to increase antibiotic yields. Some nutrients, e.g., valine, l-glutamine and maltodextrin, and some endogenous proteins, e.g., Dbv3, Dbv4 and RpoB R , have a positive role on A40926 biosynthesis, while other factors, e.g., phosphate, ammonium and Dbv23, have a negative effect. Overall, the results available so far point to a complex regulatory network controlling A40926 in the native producing strain.

  6. High-Throughput Analysis of T-DNA Location and Structure Using Sequence Capture.

    Directory of Open Access Journals (Sweden)

    Soichi Inagaki

    Full Text Available Agrobacterium-mediated transformation of plants with T-DNA is used both to introduce transgenes and for mutagenesis. Conventional approaches used to identify the genomic location and the structure of the inserted T-DNA are laborious and high-throughput methods using next-generation sequencing are being developed to address these problems. Here, we present a cost-effective approach that uses sequence capture targeted to the T-DNA borders to select genomic DNA fragments containing T-DNA-genome junctions, followed by Illumina sequencing to determine the location and junction structure of T-DNA insertions. Multiple probes can be mixed so that transgenic lines transformed with different T-DNA types can be processed simultaneously, using a simple, index-based pooling approach. We also developed a simple bioinformatic tool to find sequence read pairs that span the junction between the genome and T-DNA or any foreign DNA. We analyzed 29 transgenic lines of Arabidopsis thaliana, each containing inserts from 4 different T-DNA vectors. We determined the location of T-DNA insertions in 22 lines, 4 of which carried multiple insertion sites. Additionally, our analysis uncovered a high frequency of unconventional and complex T-DNA insertions, highlighting the needs for high-throughput methods for T-DNA localization and structural characterization. Transgene insertion events have to be fully characterized prior to use as commercial products. Our method greatly facilitates the first step of this characterization of transgenic plants by providing an efficient screen for the selection of promising lines.

  7. The Effects of Pre-Task Planning and On-line Planning on Fluency, Complexity, and Accuracy in L2 Monologic Oral Production.

    Science.gov (United States)

    Yuan, Fangyuan; Ellis, Rod

    2003-01-01

    Investigated the effects of both pre-task and on-line planning on second language (L2) oral production. Results show that pre-task planning enhances grammatical complexity while on-line planning positively influences accuracy and grammatical complexity. Pre-task planners also produced more fluent and lexically varied language than the on-line…

  8. Detection and location of leaking TRIGA fuel elements

    International Nuclear Information System (INIS)

    Bouchey, G.D.; Gage, S.J.

    1970-01-01

    Several TRIGA facilities have experienced difficulty resulting from cladding failures of aluminum clad TRIGA fuel elements. Recently, at the University of Texas at Austin reactor facility, fission product releases were observed during 250 kW operation and were attributed to a leaking fuel element. A rather extensive testing program has been undertaken to locate the faulty element. The used sniffer device is described, which provides a quick, easily constructed, and extremely sensitive means of locating leaking fuel elements. The difficulty at The University of Texas was compounded by extremely low levels and the sporadic nature of the releases. However, in the more typical situation, in which a faulty element consistently releases relatively large quantities of fission gas, such a device should locate the leak with little difficulty

  9. Using Boundary Management for More Effective Product Development

    Directory of Open Access Journals (Sweden)

    John Thomson

    2013-10-01

    Full Text Available Twenty years ago, most companies developed their own products in a single location and brought them to market themselves. Today, original equipment manufacturers (OEMs are enlisting partners on a global scale as subsystem designers and producers in order to create and deliver new products into the market more rapidly and more frequently. This is especially true for large, complex products from the aerospace, telecommunications, electronics, and software industries. To assure the delivery of information across organizational boundaries, new coordination mechanisms need to be adopted (boundary management. In this article, best practices are described on how OEMs and partners self-organize and use agile, cooperative techniques to maintain daily communication among numerous internal and partner engineers to better coordinate product design and system integration. This article focuses on examples from the aerospace industry; however; these tactics can be applied in any organization to innovate at faster rates, to make delivery times more predictable, and to realize shorter product development timelines.

  10. Finding the Subcellular Location of Barley, Wheat, Rice and Maize Proteins: The Compendium of Crop Proteins with Annotated Locations (cropPAL).

    Science.gov (United States)

    Hooper, Cornelia M; Castleden, Ian R; Aryamanesh, Nader; Jacoby, Richard P; Millar, A Harvey

    2016-01-01

    Barley, wheat, rice and maize provide the bulk of human nutrition and have extensive industrial use as agricultural products. The genomes of these crops each contains >40,000 genes encoding proteins; however, the major genome databases for these species lack annotation information of protein subcellular location for >80% of these gene products. We address this gap, by constructing the compendium of crop protein subcellular locations called crop Proteins with Annotated Locations (cropPAL). Subcellular location is most commonly determined by fluorescent protein tagging of live cells or mass spectrometry detection in subcellular purifications, but can also be predicted from amino acid sequence or protein expression patterns. The cropPAL database collates 556 published studies, from >300 research institutes in >30 countries that have been previously published, as well as compiling eight pre-computed subcellular predictions for all Hordeum vulgare, Triticum aestivum, Oryza sativa and Zea mays protein sequences. The data collection including metadata for proteins and published studies can be accessed through a search portal http://crop-PAL.org. The subcellular localization information housed in cropPAL helps to depict plant cells as compartmentalized protein networks that can be investigated for improving crop yield and quality, and developing new biotechnological solutions to agricultural challenges. © The Author 2015. Published by Oxford University Press on behalf of Japanese Society of Plant Physiologists. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  11. A Location Privacy Aware Friend Locator

    DEFF Research Database (Denmark)

    Siksnys, Laurynas; Thomsen, Jeppe Rishede; Saltenis, Simonas

    2009-01-01

    to trade their location privacy for quality of service, limiting the attractiveness of the services. The challenge is to develop a communication-efficient solution such that (i) it detects proximity between a user and the user’s friends, (ii) any other party is not allowed to infer the location of the user...

  12. Statistically designed enzymatic hydrolysis of an icariin/β-cyclodextrin inclusion complex optimized for production of icaritin

    Directory of Open Access Journals (Sweden)

    Xin Jin

    2012-02-01

    Full Text Available This study focuses on the preparation and enzymic hydrolysis of an icariin/β-cyclodextrin inclusion complex to efficiently generate icaritin. The physical characteristics of the inclusion complex were evaluated by differential scanning calorimetry (DSC. Enzymatic hydrolysis was optimized for the conversion of icariin/β-cyclodextrin complex to icaritin by Box–Behnken statistical design. The inclusion complex formulation increased the solubility of icariin approximately 17-fold, from 29.2 to 513.5 μg/mL at 60 °C. The optimum conditions were predicted by Box–Behnken statistical design as follows: 60 °C, pH 7.0, the ratio of enzyme/substrate (1:1.1 and reaction time 7 h. Under the optimal conditions the conversion of icariin was 97.91% and the reaction time was decreased by 68% compared with that without β-CD inclusion. Product analysis by melting point, ESI-MS, UV, IR, 1H NMR and 13C NMR confirmed the authenticity of icaritin with a purity of 99.3% and a yield of 473 mg of icaritin from 1.1 g icariin.

  13. Spatial complexity of carcass location influences vertebrate scavenger efficiency and species composition.

    Science.gov (United States)

    Smith, Joshua B; Laatsch, Lauren J; Beasley, James C

    2017-08-31

    Scavenging plays an important role in shaping communities through inter- and intra-specific interactions. Although vertebrate scavenger efficiency and species composition is likely influenced by the spatial complexity of environments, heterogeneity in carrion distribution has largely been disregarded in scavenging studies. We tested this hypothesis by experimentally placing juvenile bird carcasses on the ground and in nests in trees to simulate scenarios of nestling bird carrion availability. We used cameras to record scavengers removing carcasses and elapsed time to removal. Carrion placed on the ground was scavenged by a greater diversity of vertebrates and at > 2 times the rate of arboreal carcasses, suggesting arboreal carrion may represent an important resource to invertebrate scavengers, particularly in landscapes with efficient vertebrate scavenging communities. Nonetheless, six vertebrate species scavenged arboreal carcasses. Rat snakes (Elaphe obsolete), which exclusively scavenged from trees, and turkey vultures (Cathartes aura) were the primary scavengers of arboreal carrion, suggesting such resources are potentially an important pathway of nutrient acquisition for some volant and scansorial vertebrates. Our results highlight the intricacy of carrion-derived food web linkages, and how consideration of spatial complexity in carcass distribution (i.e., arboreal) may reveal important pathways of nutrient acquisition by invertebrate and vertebrate scavenging guilds.

  14. Complex Dynamics in a Triopoly Game with Multiple Delays in the Competition of Green Product Level

    Science.gov (United States)

    Si, Fengshan; Ma, Junhai

    Research on the output game behavior of oligopoly has greatly advanced in recent years. But many unknowns remain, particularly the influence of consumers’ willingness to buy green products on the oligopoly output game. This paper constructs a triopoly output game model with multiple delays in the competition of green products. The influence of the parameters on the stability and complexity of the system is studied by analyzing the existence and local asymptotic stability of the equilibrium point. It is found that the system loses stability and increases complexity if delay parameters exceed a certain range. In the unstable or chaotic game market, the decisions of oligopoly will be counterproductive. It is also observed that the influence of weight and output adjustment speed on the firm itself is obviously stronger than the influence of other firms. In addition, it is important that weight and output adjustment speed cannot increase indefinitely, otherwise it will bring unnecessary losses to the firm. Finally, chaos control is realized by using the variable feedback control method. The research results of this paper can provide a reference for decision-making for the output of the game of oligopoly.

  15. Biomass production on the Olympic and Kitsap Peninsulas, Washington: updated logging residue ratios, slash pile volume-to-weight ratios, and supply curves for selected locations

    Science.gov (United States)

    Jason C. Cross; Eric C. Turnblom; Gregory J. Ettl

    2013-01-01

    Biomass residue produced by timber harvest operations is estimated for the Olympic and Kitsap Peninsulas, Washington. Scattered residues were sampled in 53 harvest units and piled residues were completely enumerated in 55 harvest units. Production is based on 2008 and 2009 data and is stratified by forest location, ownership type, harvest intensity, and harvest method...

  16. Complexity of Economical Systems

    Directory of Open Access Journals (Sweden)

    G. P. Pavlos

    2015-01-01

    Full Text Available In this study new theoretical concepts are described concerning the interpretation of economical complex dynamics. In addition a summary of an extended algorithm of nonlinear time series analysis is provided which is applied not only in economical time series but also in other physical complex systems (e.g. [22, 24]. In general, Economy is a vast and complicated set of arrangements and actions wherein agents—consumers, firms, banks, investors, government agencies—buy and sell, speculate, trade, oversee, bring products into being, offer services, invest in companies, strategize, explore, forecast, compete, learn, innovate, and adapt. As a result the economic and financial variables such as foreign exchange rates, gross domestic product, interest rates, production, stock market prices and unemployment exhibit large-amplitude and aperiodic fluctuations evident in complex systems. Thus, the Economics can be considered as spatially distributed non-equilibrium complex system, for which new theoretical concepts, such as Tsallis non extensive statistical mechanics and strange dynamics, percolation, nonGaussian, multifractal and multiscale dynamics related to fractional Langevin equations can be used for modeling and understanding of the economical complexity locally or globally.

  17. The influence of operational constraints in the production strategy definition; Influencia de restricoes operacionais na definicao da estrategia de producao

    Energy Technology Data Exchange (ETDEWEB)

    Magalhaes, Tasso C.B. de; Schiozer, Denis J. [Universidade Estadual de Campinas, SP (Brazil)

    2004-07-01

    Production strategies definition, applied to petroleum fields, must consider physical, operational and economic constraints. It is common to consider only the reservoir conditions on the optimization processes, simplifying, many times, the process by not taking into account the operational constraints due to production facilities. There are two main reasons: considering the operational constraints makes the process much complex and it is assumed that this simplification can affect the economic indicators but dos not affect significantly the optimization process (number e location of wells, for example). The capacity of a production unit can be limited by many constrains such as: maximum liquid rate, capacity of water and gas treatment, gas compression, water or gas injection, number of wells, etc. In this work, we show that these limitations have a direct influence in the oil production and consequently in the economic indicators and they can cause significant impact at production strategy definition, influencing the number of production and injection wells, their locations and their operational conditions. We presented an example of an offshore field with a limitation on the liquid rate. Production strategies were selected with and without constraints in order to observe the differences in the technical and economic indicators, such as NPV (Net Present Value), production and injection of fluids and the number and location of the production and injection wells. It was possible to observe yet that the amount and location of the wells were significantly affected by the restriction. (author)

  18. Central Waste Complex (CWC) Waste Analysis Plan

    International Nuclear Information System (INIS)

    ELLEFSON, M.D.

    2000-01-01

    The purpose of this waste analysis plan (WAP) is to document the waste acceptance process, sampling methodologies, analytical techniques, and overall processes that are undertaken for waste accepted for storage at the Central Waste Complex (CWC), which is located in the 200 West Area of the Hanford Facility, Richland, Washington. Because dangerous waste does not include the source special nuclear and by-product material components of mixed waste, radionuclides are not within the scope of this document. The information on radionuclides is provided only for general knowledge. This document has been revised to meet the interim status waste analysis plan requirements of Washington Administrative Code (WAC) 173 303-300(5). When the final status permit is issued, permit conditions will be incorporated and this document will be revised accordingly

  19. Advertising, product quality, and complex evolving marketing systems

    OpenAIRE

    Verbeke, Willem

    1992-01-01

    textabstractThe paper analyses the advertising as power vs. advertising as information controversy as well as its recent empirical testing. It is stressed that this distinction focuses too much on the interaction between consumer and manufacturer while ignoring the retailer as an important stake-holder. To compensate for this lack, a complex marketing system perspective is introduced in which consumer, retailer, and manufacturer interact. However, these complex marketing systems might drift t...

  20. Lattice location of transition metals in silicon by means of emission channeling

    CERN Document Server

    da Silva, Daniel José; Wahl, Ulrich; Correia, João Guilherme

    The behavior of transition metals (TMs) in silicon is a subject that has been studied extensively during the last six decades. Their unintentional introduction during the Si production, crystal growth and device manufacturing have made them difficult contaminants to avoid. Once in silicon they easily form deep levels, either when in the isolated form or when forming precipitates. One important effect is the reduction of efficiency of silicon-based devices, being dramatic, in particular, in photovoltaic applications. One way to avoid such effects is by engineering the location of the TM: some TM complexes or lattice sites of the isolated form do not introduce any level in the silicon bandgap. Which point defects lead to such passivation is still under debate. Another way is to mitigate the reduction of efficiency by reducing the dangling bonds of TMs with hydrogen. The most important and commonly used procedures to diminish the unwanted effects of the introduced deep levels are, nevertheless, based on the so-c...

  1. Locative media

    CERN Document Server

    Wilken, Rowan

    2014-01-01

    Not only is locative media one of the fastest growing areas in digital technology, but questions of location and location-awareness are increasingly central to our contemporary engagements with online and mobile media, and indeed media and culture generally. This volume is a comprehensive account of the various location-based technologies, services, applications, and cultures, as media, with an aim to identify, inventory, explore, and critique their cultural, economic, political, social, and policy dimensions internationally. In particular, the collection is organized around the perception that the growth of locative media gives rise to a number of crucial questions concerning the areas of culture, economy, and policy.

  2. Interaction between NBS1 and the mTOR/Rictor/SIN1 complex through specific domains.

    Directory of Open Access Journals (Sweden)

    Jian-Qiu Wang

    Full Text Available Nijmegen breakage syndrome (NBS is a chromosomal-instability syndrome. The NBS gene product, NBS1 (p95 or nibrin, is a part of the Mre11-Rad50-NBS1 complex. SIN1 is a component of the mTOR/Rictor/SIN1 complex mediating the activation of Akt. Here we show that NBS1 interacted with mTOR, Rictor, and SIN1. The specific domains of mTOR, Rictor, or SIN1 interacted with the internal domain (a.a. 221-402 of NBS1. Sucrose density gradient showed that NBS1 was located in the same fractions as the mTOR/Rictor/SIN1 complex. Knockdown of NBS1 decreased the levels of phosphorylated Akt and its downstream targets. Ionizing radiation (IR increased the NBS1 levels and activated Akt activity. These results demonstrate that NBS1 interacts with the mTOR/Rictor/SIN1 complex through the a.a. 221-402 domain and contributes to the activation of Akt activity.

  3. Personalized Location-Based Recommendation Services for Tour Planning in Mobile Tourism Applications

    Science.gov (United States)

    Yu, Chien-Chih; Chang, Hsiao-Ping

    Travel and tour planning is a process of searching, selecting, grouping and sequencing destination related products and services including attractions, accommodations, restaurants, and activities. Personalized recommendation services aim at suggesting products and services to meet users’ preferences and needs, while location-based services focus on providing information based on users’ current positions. Due to the fast growing of user needs in the mobile tourism domain, how to provide personalized location-based tour recommendation services becomes a critical research and practical issue. The objective of this paper is to propose a system architecture and design methods for facilitating the delivery of location-based recommendation services to support personalized tour planning. Based on tourists’ current location and time, as well as personal preferences and needs, various recommendations regarding sightseeing spots, hotels, restaurants, and packaged tour plans can be generated efficiently. An application prototype is also implemented to illustrate and test the system feasibility and effectiveness.

  4. Effects of 4D-Var Data Assimilation Using Remote Sensing Precipitation Products in a WRF Model over the Complex Terrain of an Arid Region River Basin

    Directory of Open Access Journals (Sweden)

    Xiaoduo Pan

    2017-09-01

    Full Text Available Individually, ground-based, in situ observations, remote sensing, and regional climate modeling cannot provide the high-quality precipitation data required for hydrological prediction, especially over complex terrains. Data assimilation techniques can be used to bridge the gap between observations and models by assimilating ground observations and remote sensing products into models to improve precipitation simulation and forecasting. However, only a small portion of satellite-retrieved precipitation products assimilation research has been implemented over complex terrains in an arid region. Here, we used the weather research and forecasting (WRF model to assimilate two satellite precipitation products (The Tropical Rainfall Measuring Mission: TRMM 3B42 and Fengyun-2D: FY-2D using the 4D-Var data assimilation method for a typical inland river basin in northwest China’s arid region, the Heihe River Basin, where terrains are very complex. The results show that the assimilation of remote sensing precipitation products can improve the initial WRF fields of humidity and temperature, thereby improving precipitation forecasting and decreasing the spin-up time. Hence, assimilating TRMM and FY-2D remote sensing precipitation products using WRF 4D-Var can be viewed as a positive step toward improving the accuracy and lead time of numerical weather prediction models, particularly over regions with complex terrains.

  5. The Tools of Financial Policy in the Dairy Products Subdivision of the Agroindustrial Complex

    Directory of Open Access Journals (Sweden)

    Bielosviet Oleksandr. V.

    2017-03-01

    Full Text Available The article is aimed at definition and classification of tools of the State financial policy in the dairy products subdivision of the agroindustrial complex (DPS of AIC. The article considers the financial policy tools used in terms of targeted programs of the State support for the DPS of AIC: the State target program for development of Ukrainian villages, sectoral program for dairy breeding and the project of the conception of the State target program for development of dairy breeding in Ukraine for the period up to 2020. The existing tools are divided into direct and indirect action tools. As of 2016, the tasks that were relevant to the corresponding targeted programs have not been implemented on any item, except for the milk productivity of cows. Still the productivity indicator of 4500 kg/year of milk from a cow is low enough and does not correspond to the general world-wide tendencies. This suggests the need for further assessment of the existing list of tools with a view to adjusting them and defining priorities for the State support of the DPS of AIC.

  6. Selecting optimum locations for co-located wave and wind energy farms. Part II: A case study

    International Nuclear Information System (INIS)

    Astariz, S.; Iglesias, G.

    2016-01-01

    Highlights: • The benefits of wave and wind combined systems relative to independent farms are analysed. • This purpose is carried out through a case study off the Danish coast. • The power production, power smoothing and shadow effect are analysed. • Hindcast and measured wave and wind data from 2005 to 2015 are used. • Third-generation models of winds and waves (WAsP and SWAN) are used. - Abstract: Combined energy systems present an opportunity to enhance the competitiveness of renewables and overcome other challenges of these novel renewables by realising the synergies between them. Among the different possibilities for combined systems, this work focuses on wave and wind co-located farms with the aim of assessing their benefits relative to standalone wind farms. To this end we estimate the energy production, investigate the power smoothing and shadow effect, and quantify the reduction in downtime achieved by the co-located farm through a case study off the Danish coast – a promising area for co-located farms based on the available resource and other considerations including technical constraints. The analysis is carried out based on hindcast data and observations extending from 2005 to 2015, and by means of state-of-the-art numerical models of the wind and wave fields – WAsP and SWAN, respectively. It is found that the energy yield per unit area with the combined wave-wind farm increases by 3.4% relative to a standalone wind farm, the downtime periods decrease by 58% and the power output variability reduces by 12.5%. Moreover, the capital and operational expenditures (CAPEX and OPEX, respectively) would also be significantly reduced thanks to the synergies realised through the combination of wind and wave power.

  7. Chicken feather hydrolysate as an inexpensive complex nitrogen source for PHA production by Cupriavidus necator on waste frying oils.

    Science.gov (United States)

    Benesova, P; Kucera, D; Marova, I; Obruca, S

    2017-08-01

    The chicken feather hydrolysate (FH) has been tested as a potential complex nitrogen source for the production of polyhydroxyalkanoates by Cupriavidus necator H16 when waste frying oil was used as a carbon source. The addition of FH into the mineral salt media with decreased inorganic nitrogen source concentration improved the yields of biomass and polyhydrohyalkanoates. The highest yields were achieved when 10 vol.% of FH prepared by microwave-assisted alkaline hydrolysis of 60 g l -1 feather was added. In this case, the poly(3-hydroxybutyrate) (PHB) yields were improved by more than about 50% as compared with control cultivation. A positive impact of FH was also observed for accumulation of copolymer poly(3-hydroxybutyrate-co-3-hydroxyvalerate) when sodium propionate was used as a precursor. The copolymer has superior processing and mechanical properties in comparison with PHB homopolymer. The application of FH eliminated the inhibitory effect of propionate and resulted in altered content of 3-hydroxyvalerate (3HV) in copolymer. Therefore, the hydrolysed feather can serve as an excellent complex source of nitrogen for the polyhydroxyalkanoates (PHA) production. Moreover, by the combination of two inexpensive types of waste, such as waste frying oil and feather hydrolysate, it is possible to produce PHA with substantially improved efficiency and sustainability. Millions of tons of feathers, important waste product of poultry-processing industry, are disposed off annually without any further benefits. Thus, there is an inevitable need for new technologies that enable ecologically and economically sensible processing of this waste. Herein, we report that alkali-hydrolysed feathers can be used as a complex nitrogen source considerably improving polyhydroxyalkanoates production on waste frying oil employing Cupriavidus necator. © 2017 The Society for Applied Microbiology.

  8. Housing the Mobile Entrepeneur. The location behavior of firms in urban residential neighbourhoods

    NARCIS (Netherlands)

    Risselada, A.H.

    2013-01-01

    Changing economic production processes have opened up new locational demands for firms and have led to an increasingly diverse firm population displaying fragmented location patterns. This research focuses on those spatial configurations that fit the current economic fragmentation and changing

  9. The crystal structure of Lactococcus lactis dihydroorotate dehydrogenase A complexed with the enzyme reaction product throws light on its enzymatic function

    DEFF Research Database (Denmark)

    Rowland, Paul; Bjørnberg, Olof; Nielsen, Finn S.

    1998-01-01

    Dihydroorotate dehydrogenases (DHODs) catalyze the oxidation of (S)-dihydroorotate to orotate, the fourth step and only redox reaction in the de novo biosynthesis of pyrimidine nucleotides. A description is given of the crystal structure of Lactococcus lactis dihydroorotate dehydrogenase A (DHODA......) complexed with the product of the enzyme reaction orotate. The structure of the complex to 2.0 A resolution has been compared with the structure of the native enzyme. The active site of DHODA is known to contain a water filled cavity buried beneath a highly conserved and flexible loop. In the complex...

  10. An FBG acoustic emission source locating system based on PHAT and GA

    Science.gov (United States)

    Shen, Jing-shi; Zeng, Xiao-dong; Li, Wei; Jiang, Ming-shun

    2017-09-01

    Using the acoustic emission locating technology to monitor the health of the structure is important for ensuring the continuous and healthy operation of the complex engineering structures and large mechanical equipment. In this paper, four fiber Bragg grating (FBG) sensors are used to establish the sensor array to locate the acoustic emission source. Firstly, the nonlinear locating equations are established based on the principle of acoustic emission, and the solution of these equations is transformed into an optimization problem. Secondly, time difference extraction algorithm based on the phase transform (PHAT) weighted generalized cross correlation provides the necessary conditions for the accurate localization. Finally, the genetic algorithm (GA) is used to solve the optimization model. In this paper, twenty points are tested in the marble plate surface, and the results show that the absolute locating error is within the range of 10 mm, which proves the accuracy of this locating method.

  11. Product configuration for making quotations for complex and highly engineered products

    DEFF Research Database (Denmark)

    Hvam, Lars; Lisbjerg, Torben

    2007-01-01

    This presentation will describe a practical implementation of a configuration system at F.L. Smidth, which is a Danish cement plant manufacturer. The prototype of this system was developed from 1998-1999 and it was based on a procedure for building product models developed by the Centre for Product...

  12. Location of Urban Logistic Terminals as Hub Location Problem

    Directory of Open Access Journals (Sweden)

    Jasmina Pašagić Škrinjar

    2012-09-01

    Full Text Available In this paper the problems of locating urban logistic terminals are studied as hub location problems that due to a large number of potential nodes in big cities belong to hard non-polynomial problems, the so-called NP-problems. The hub location problems have found wide application in physical planning of transport and telecommunication systems, especially systems of fast delivery, networks of logistic and distribution centres and cargo traffic terminals of the big cities, etc. The paper defines single and multiple allocations and studies the numerical examples. The capacitated single allocation hub location problems have been studied, with the provision of a mathematical model of selecting the location for the hubs on the network. The paper also presents the differences in the possibilities of implementing the exact and heuristic methods to solve the actual location problems of big dimensions i.e. hub problems of the big cities.

  13. The spatial and urban planning concerns related to nuclear facilities locations: Case study of the Vinča Institute location

    Directory of Open Access Journals (Sweden)

    Stefanović Nebojša D.

    2017-01-01

    Full Text Available The spatial and urban planning is one of the key instruments for the planned formation and development of locations for nuclear facilities, especially in terms of meeting the strict spatial conditionality, as well as in terms of the formation of protection zones in their surroundings. This paper systemizes the international criteria and requirements for the locations of nuclear facilities and analyses the spatial distribution of nuclear facilities in the surrounding countries of the Republic of Serbia. The research was conducted on the example of the location of the Vinča Institute of Nuclear Sciences, within which the fulfilment of spatial requirements, treatment of the location in the existing spatial and urban plans and relationship between other functions in the surrounding area were analysed. The paper proves the starting hypothesis that the general requirements related to both the spatial development of nuclear facilities locations and the protection from radiation have not been met in the Vinča location and its surroundings. It was determined that the spatial and urban plans encompassing the area of Vinča do not contain sufficiently specific planning solutions and that, as such, they do not provide a sufficient planning basis for meeting the necessary requirements and obligations regarding the protection from radiation. The paper also gives recommendations for further spatial development and protection of the Vinča location and its surroundings. The research condcted in this paper indicates the importance and priority of further research so that the necessary planning solutions for further development of the complex in Vinča and for the formation of protection zones could be defined through creating a new planning documentation. In addition, the paper particularly highlights the need for conducting a research to identify a location for permanent disposal of radioactive waste. It also indicates the necessity of considering the aspects

  14. Integration of Microalgae-Based Bioenergy Production into a Petrochemical Complex: Techno-Economic Assessment

    Directory of Open Access Journals (Sweden)

    Ana L. Gonçalves

    2016-03-01

    Full Text Available The rapid development of modern society has resulted in an increased demand for energy, mainly from fossil fuels. The use of this source of energy has led to the accumulation of carbon dioxide (CO2 in the atmosphere. In this context, microalgae culturing may be an effective solution to reduce the CO2 concentration in the atmosphere, since these microorganisms can capture CO2 and, simultaneously, produce bioenergy. This work consists of a techno-economic assessment of a microalgal production facility integrated in a petrochemical complex, in which established infrastructure allows efficient material and energy transport. Seven different scenarios were considered regarding photosynthetic, lipids extraction and anaerobic digestion efficiencies. This analysis has demonstrated six economically viable scenarios able to: (i reduce CO2 emissions from a thermoelectric power plant; (ii treat domestic wastewaters (which were used as culture medium; and (iii produce lipids and electrical and thermal energy. For a 100-ha facility, considering a photosynthetic efficiency of 3%, a lipids extraction efficiency of 75% and an anaerobic digestion efficiency of 45% (scenario 3, an economically viable process was obtained (net present value of 22.6 million euros, being effective in both CO2 removal (accounting for 1.1 × 104 t per year and energy production (annual energy produced was 1.6 × 107 kWh and annual lipids productivity was 1.9 × 103 m3.

  15. An Approach Using Gas Monitoring to Find the Residual TCE Location in the Unsaturated Zone of Woosan Industrial Complex (WIC), Korea

    Science.gov (United States)

    Koh, Y.; Lee, S.; Yang, J.; Lee, K.

    2012-12-01

    An area accommodating various industrial facilities has fairly high probability of groundwater contamination with multiple chlorinated solvents such as trichloroethene (TCE), carbon tetrachloride (CT), and chloroform (CF). Source tracing of chlorinated solvents in the unsaturated zone is an essential procedure for the management and remediation of contaminated area. From the previous study on seasonal variations in hydrological stresses and spatial variations in geologic conditions on a TCE plume, the existence of residual DNAPLs at or above the water table has proved. Since TCE is one of the frequently detected VOCs (Volatile Organic Compounds) in groundwater, residual TCE can be detected by gas monitoring. Therefore, monitoring of temporal and spatial variations in the gas phase TCE contaminant at an industrial complex in Wonju, Korea, were used to find the residual TCE locations. As pilot tests, TCE gas samples collected in the unsaturated zone at 4 different wells were analyzed using SPME (Solid Phase MicroExtraction) fiber and Gas Chromatography (GC). The results indicated that detecting TCE in gas phase was successful from these wells and TCE analysis on gas samples, collected from the unsaturated zone, will be useful for source area characterization. However, some values were too high to doubt the accuracy of the current method, which needs a preliminary lab test with known concentrations. The modified experiment setups using packer at different depths are in process to find residual TCE locations in the unsaturated zone. Meanwhile, several PVD (polyethylene-membrane Passive Vapor Diffusion) samplers were placed under water table to detect VOCs by equilibrium between air in the vial and VOCs in pore water.

  16. Competition in Multiple Characteristics: An Empirical Test of Location Equilibrium.

    OpenAIRE

    Elizalde, J. (Javier)

    2010-01-01

    With products differentiated in multiple dimensions, the location equilibrium for a duopolistic market exhibits aximum differentiation in one dimension and minimum differentiation in all the other dimensions. This paper analyses whether this equilibrium arises using real data for the Spanish movie theatre exhibition market where the firms (cinemas) are differentiated along two dimensions (their geographical location and the set of movies exhibited). Data not only shows a trade-off such that c...

  17. Crystal structure of an EAL domain in complex with reaction product 5'-pGpG.

    Directory of Open Access Journals (Sweden)

    Julien Robert-Paganin

    Full Text Available FimX is a large multidomain protein containing an EAL domain and involved in twitching motility in Pseudomonas aeruginosa. We present here two crystallographic structures of the EAL domain of FimX (residues 438-686: one of the apo form and the other of a complex with 5'-pGpG, the reaction product of the hydrolysis of c-di-GMP. In both crystal forms, the EAL domains form a dimer delimiting a large cavity encompassing the catalytic pockets. The ligand is trapped in this cavity by its sugar phosphate moiety. We confirmed by NMR that the guanine bases are not involved in the interaction in solution. We solved here the first structure of an EAL domain bound to the reaction product 5'-pGpG. Though isolated FimX EAL domain has a very low catalytic activity, which would not be significant compared to other catalytic EAL domains, the structure with the product of the reaction can provides some hints in the mechanism of hydrolysis of the c-di-GMP by EAL domains.

  18. Crystal structure of an EAL domain in complex with reaction product 5'-pGpG.

    Science.gov (United States)

    Robert-Paganin, Julien; Nonin-Lecomte, Sylvie; Réty, Stéphane

    2012-01-01

    FimX is a large multidomain protein containing an EAL domain and involved in twitching motility in Pseudomonas aeruginosa. We present here two crystallographic structures of the EAL domain of FimX (residues 438-686): one of the apo form and the other of a complex with 5'-pGpG, the reaction product of the hydrolysis of c-di-GMP. In both crystal forms, the EAL domains form a dimer delimiting a large cavity encompassing the catalytic pockets. The ligand is trapped in this cavity by its sugar phosphate moiety. We confirmed by NMR that the guanine bases are not involved in the interaction in solution. We solved here the first structure of an EAL domain bound to the reaction product 5'-pGpG. Though isolated FimX EAL domain has a very low catalytic activity, which would not be significant compared to other catalytic EAL domains, the structure with the product of the reaction can provides some hints in the mechanism of hydrolysis of the c-di-GMP by EAL domains.

  19. On intra-supply chain system with an improved distribution plan, multiple sales locations and quality assurance.

    Science.gov (United States)

    Chiu, Singa Wang; Huang, Chao-Chih; Chiang, Kuo-Wei; Wu, Mei-Fang

    2015-01-01

    Transnational companies, operating in extremely competitive global markets, always seek to lower different operating costs, such as inventory holding costs in their intra- supply chain system. This paper incorporates a cost reducing product distribution policy into an intra-supply chain system with multiple sales locations and quality assurance studied by [Chiu et al., Expert Syst Appl, 40:2669-2676, (2013)]. Under the proposed cost reducing distribution policy, an added initial delivery of end items is distributed to multiple sales locations to meet their demand during the production unit's uptime and rework time. After rework when the remaining production lot goes through quality assurance, n fixed quantity installments of finished items are then transported to sales locations at a fixed time interval. Mathematical modeling and optimization techniques are used to derive closed-form optimal operating policies for the proposed system. Furthermore, the study demonstrates significant savings in stock holding costs for both the production unit and sales locations. Alternative of outsourcing product delivery task to an external distributor is analyzed to assist managerial decision making in potential outsourcing issues in order to facilitate further reduction in operating costs.

  20. On the identification of complexing radiolysis products in the Purex system. (20%TBP - Dodecane - HNO3)

    International Nuclear Information System (INIS)

    Becker, R.; Baumgartner, F.; Steiglitz, L.

    1978-09-01

    The lifetime of the extraction system TBP Dodecane-aqueous HNO. In the Purex process is limited by radiolytic and hydrolytic decomposition of the extracting and diluting agent which is indicated by an increased retention of fission products, especially zirconium. In this work, the radiolytically formed complexing agents responsible for this are enriched (molecular distillation) and separated in several fractions by liquid chromatography. The chemical composition of these fractions was identified by a combination of gas chromatography and mass spectrometry, supplemented by infra-red spectroscopy. As for doubtful complexing agents, they are mainly long-chain phosphoric acid esters, and, to a lesser extent, the existence of polycarbonyl compounds is suspected. The high molecular weight components of the phosphate ester fraction could be separated by gas chromatography and identified as oligomeric phosphate esters. (author)

  1. Location, location, location: does early cancer in Barrett's esophagus have a preference?

    Science.gov (United States)

    Enestvedt, Brintha K; Lugo, Ricardo; Guarner-Argente, Carlos; Shah, Pari; Falk, Gary W; Furth, Emma; Ginsberg, Gregory G

    2013-09-01

    Early cancer (high-grade dysplasia [HGD] and intramucosal carcinoma [ImCa]) associated with Barrett's esophagus (BE) may have a circumferential spatial predilection. To describe the esophageal circumferential location of early cancer in BE. Retrospective study, single tertiary referral center. One hundred nineteen patients were referred for endoscopic eradication therapy for early cancer associated with BE. Endoscopic images and reports and pathology were reviewed. Circumferential location designation of early cancer in BE by using a clock-face orientation. One hundred nineteen of 131 patients referred for endoscopic eradication therapy had a location designation for their advanced histology (91.9%). There were a total of 57 patients (47.9%) with HGD and 62 patients (52.1%) with ImCa. There was a significantly higher rate of early cancer (HGD or ImCa) in the right hemisphere (12 to 6 o'clock location) compared with the left hemisphere (84.9% vs 15.1%, P cancer was found in the 12 to 3 o'clock quadrant (64.7%); 71.9% of HGD and 58.1% of ImCa lesions were located in the 12 to 3 o'clock quadrant. Retrospective design, single center. Early cancer associated with BE is far more commonly found in the right hemisphere of the esophagus (12 to 6 o'clock) with the highest rate in the 12 to 3 o'clock quadrant. These findings support enhanced scrutiny of the right hemisphere of the esophagus during surveillance and endoscopic treatment of patients with BE. Copyright © 2013 American Society for Gastrointestinal Endoscopy. Published by Mosby, Inc. All rights reserved.

  2. Determining potential locations for biomass valorization using a macro screening approach

    Energy Technology Data Exchange (ETDEWEB)

    Van Dael, M.; Van Passel, S.; Schreurs, E. [Research Group of Environmental Economics, Centre for Environmental Sciences, Hasselt University, Agoralaan Gebouw D, 3590 Diepenbeek (Belgium); Pelkmans, L.; Guisson, R. [VITO, Boeretang 200, 2400 Mol (Belgium); Swinnen, G. [Research Group of Marketing, Hasselt University, Agoralaan Gebouw D, 3590 Diepenbeek (Belgium)

    2012-10-15

    European policy states that by 2020 at least 20% of final energy consumption should come from renewable energy sources. Biomass as a renewable energy source cannot be disregarded in order to attain this target. In this study a macro screening approach is developed to determine potential locations for biomass valorization in a specified region. The approach consists of five steps: (1) criteria determination, (2) data gathering, (3) weight assignment, (4) final score, (5) spatial representation. The resulting outcome provides a first well balanced scan of the possibilities for energy production using regional biomass. This way policy makers and investors can be supported and motivated to study the possibilities of building energy production plants at specific locations in more detail, which can be described as a 'micro-screening'. In our case study the approach is applied to determine the potentially interesting locations to establish a biomass project. The region has been limited to the forty-four communities in the province of Limburg (Belgium). The macro screening approach has shown to be very effective since the amount of interesting locations has been reduced drastically.

  3. In-situ complex with by-product HCl and release chloride ions to dissolve aramid.

    Science.gov (United States)

    Dai, Yu; Cheng, Zheng; Yuan, Yihao; Meng, Chenbo; Qin, Jiaqiang; Liu, Xiangyang

    2018-06-20

    Because of the strong hydrogen-bond interaction among macromolecular chains, addition of chloride salts is generally needed to offer Cl- ions for dissolution of aromatic polyamides. In this paper, poly-(benzimidazole-terephthalamide) which complexed with by-product HCl during polymerization (PABI-HCl) was prepared and imidazole compound as cosolvent was added into dimethylacetamide (DMAc) to dissolve PABI-HCl. Due to stronger affinity to protons, imidazole compound could in-situ complex with HCl of PABI-HCl and form imidazolium hydrochloride. Then imidazolium hydrochloride would ionize and produce much free Cl- ions which acted as stronger hydrogen-bond acceptor to disrupt interaction among macromolecular chains. As a result, solubility of PABI-HCl in DMAc was improved significantly in existence of small amount of imidazole compound. Moreover, DMAc-imidazole mixture was utlized for synthesis of different kinds of aramids and no precipitation was observed with progress of the reaction. So the mixture was suitable to be utlized as solvent for polymerization of aramid. © 2018 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  4. Geochemistry of the Bayonplutonic Complex – Western Cameroon ...

    African Journals Online (AJOL)

    The BayonNeoproterozoic plutonic complex located in Western Cameroon intrudes gneisses of Paleo to Neo Proterozoic age. The complex is composed of gabbro, monzogabbro and monzonites frequently crosscut by trachytic and granitic veins. The primary mineral assemblages of the gabbro and monzogabbro is ...

  5. A note on a profit maximizing location model

    NARCIS (Netherlands)

    S. Zhang (Shuzhong)

    1997-01-01

    textabstractIn this paper we discuss a locational model with a profit-maximizing objective. The model can be illustrated by the following situation. There is a set of potential customers in a given region. A firm enters the market and wants to sell a certain product to this set of customers. The

  6. Protein Complex Production from the Drug Discovery Standpoint.

    Science.gov (United States)

    Moarefi, Ismail

    2016-01-01

    Small molecule drug discovery critically depends on the availability of meaningful in vitro assays to guide medicinal chemistry programs that are aimed at optimizing drug potency and selectivity. As it becomes increasingly evident, most disease relevant drug targets do not act as a single protein. In the body, they are instead generally found in complex with protein cofactors that are highly relevant for their correct function and regulation. This review highlights selected examples of the increasing trend to use biologically relevant protein complexes for rational drug discovery to reduce costly late phase attritions due to lack of efficacy or toxicity.

  7. Innovative processes impact on the factors optimal number formation of the enterprise location

    OpenAIRE

    Franiv Ihor Andriiovych

    2014-01-01

    The aim of the article. Determination of the factors to locate enterprises for searching optimal location place, therefore grounding enterprise location place with one or several factors one should consider innovative development nowadays. The results of the analysis. The branches referring to this or that production group will always have relative character and will concern time period, because – various factors value can be changed under influence of innovation introduction. Technologica...

  8. 27 CFR 46.243 - Articles at multiple locations.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 2 2010-04-01 2010-04-01 false Articles at multiple... Cigarette Tubes Held for Sale on April 1, 2009 Records § 46.243 Articles at multiple locations. The dealer must maintain a list of all places where the dealer holds articles subject to the floor stocks tax...

  9. Location-quality-aware policy optimisation for relay selection in mobile networks

    DEFF Research Database (Denmark)

    Nielsen, Jimmy Jessen; Olsen, Rasmus Løvenstein; Madsen, Tatiana Kozlova

    2016-01-01

    for resulting performance of such network optimizations. In mobile scenarios, the required information collection and forwarding causes delays that will additionally affect the reliability of the collected information and hence will influence the performance of the relay selection method. This paper analyzes...... the joint influence of these two factors in the decision process for the example of a mobile location-based relay selection approach using a continuous time Markov chain model. Efficient algorithms are developed based on this model to obtain optimal relay policies under consideration of localization errors....... Numerical results show how information update rates, forwarding delays, and location estimation errors affect these optimal policies and allow to conclude on the required accuracy of location-based systems for such mobile relay selection scenarios. A measurement-based indoor scenario with more complex...

  10. Sustainable use of marine resources through offshore wind and mussel farm co-location

    DEFF Research Database (Denmark)

    Di Tullio, Giacomo R.; Mariani, Patrizio; Benassai, Guido

    2018-01-01

    wind farms and open-water mussel cultivation. An index of co-location sustainability (SI) was developed based on the application of MCE technique constructed with physical and biological parameters on the basis of remote-sensing data. The relevant physical factors considered were wind velocity, depth...... range, concerning the site location for energy production, and sea surface temperature anomaly. The biological variables used were Chlorofill-a (as a measurement of the productivity) and Particle Organic Carbon(POC) concentration, in order to assess their influence on the probable benefits and complete...

  11. Geochemistry of Gneisses from Dabie Complex and Tongbai Complex in Qinling-Tongbai-Dabie Orogenic Belt: Implications for Location of Yangtze-Sino-Korean Suture

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    The Dabie complex (DC) and the Tongbai complex (TBC) are separately distributed in the middle and eastern parts of the Qinling-Tongbai-Dabie orogenic belt. In this study, the Dabie complex can be divided into two units: one is the complex with no high pressure and ultrahigh pressure metamorphic rocks (DC1), and the other is the complex containing coesite-bearing eclogite lenses or boudins (DC2). Gneisses are predominant in the TBC, DC1 and DC2. Major and trace element data of gneisses in the TBC, DC1 and DC2 show them to be the orthogneisses. The gneisses in the DC1 have higher incompatible element contents and higher ratios of w(K2O)/w(Na2O) and w(La)n/w(Yb)n than those in the DC2. However, no obvious differences arise in other element contents and the ratios of w(La)/w( Nb), w(Nb)/w(Th), w(Nb)/w(Hf), w(Ba)/w(La), w(Sm)/w(Nd) and w(Th)/w(U) between the gneisses in the DC2 and those in the DC1. These observations suggest that the protoliths of the gneisses in the DC2 have affinities to those in the DC1. The difference between the DC1 and DC2 gneisses in incompat- ible element contents could reflect the difference in their partial melting extent. The TBC gneisses are geochemically similar to the DC1 gneisses, suggesting that the TBC and DC1 gneisses are the same lithologic unit in the Qinling-Tongbai-Dabie orogenic belt and that they have experienced similar formations and evolution histories. In the Qinling-Tongbai area, the TBC is part of the northern blocks of the Yangtze craton. Given the similarity of geochemical characteristics, the rock assemblage and the ages between the TBC and DC1 gneisses, we can infer that the Dabie complex also belongs to the northern blocks of the Yangtze craton. In terms of the distribution of eciogites and metamorphic facies, we propose that the collisionai suture in the Dabie area is distributed along the Xiaotian-Mozitan fault, at the contact with the Shang-Dan-Tongbai fault to the west.

  12. Perception of dimethyl sulfide (DMS) by loggerhead sea turtles: a possible mechanism for locating high-productivity oceanic regions for foraging.

    Science.gov (United States)

    Endres, Courtney S; Lohmann, Kenneth J

    2012-10-15

    During their long-distance migrations, sea turtles of several species feed on jellyfish and other invertebrates that are particularly abundant in ocean regions characterized by high productivity. An ability to distinguish productive oceanic regions from other areas, and to concentrate foraging activities in locations where prey density is highest, might therefore be adaptive. The volatile compound dimethyl sulfide (DMS) accumulates in the air above productive ocean areas such as upwelling and frontal zones. In principle, DMS might therefore serve as an indicator of high prey density for turtles. To determine whether turtles perceive DMS, juvenile loggerhead sea turtles (Caretta caretta) were placed into a water-filled arena in which DMS and other odorants could be introduced to the air above the water surface. Turtles exposed to air that had passed over a cup containing 10 nmol l(-1) DMS spent more time at the surface with their noses out of the water than control turtles, which were exposed to air that had passed over a cup containing distilled water. Odors that do not occur in the sea (cinnamon, jasmine and lemon) did not elicit increased surface time, implying that the response to DMS is unlikely to reflect a generalized response to any novel odor. The results demonstrate for the first time that sea turtles can detect DMS, an ability that might enable the identification of favorable foraging areas.

  13. Exploring the Utilization of Complex Algal Communities to Address Algal Pond Crash and Increase Annual Biomass Production for Algal Biofuels

    Energy Technology Data Exchange (ETDEWEB)

    Hamilton, Cyd E. [Dept. of Energy (DOE), Washington DC (United States).

    2014-03-25

    This white paper briefly reviews the research literature exploring complex algal communities as a means of increasing algal biomass production via increased tolerance, resilience, and resistance to a variety of abiotic and biotic perturbations occurring within harvesting timescales. This paper identifies what data are available and whether more research utilizing complex communities is needed to explore the potential of complex algal community stability (CACS) approach as a plausible means to increase biomass yields regardless of ecological context and resulting in decreased algal-based fuel prices by reducing operations costs. By reviewing the literature for what we do and do not know, in terms of CACS methodologies, this report will provide guidance for future research addressing pond crash phenomena.

  14. Is dense codeswitching complex?

    NARCIS (Netherlands)

    Dorleijn, M.

    In this paper the question is raised to what extent dense code switching can be considered complex. Psycholinguistic experiments indicate that code switching involves cognitive costs, both in production and comprehension, a conclusion that could indicate that code switching is indeed complex. In

  15. Milk quality and financial management at different scales of production on dairy farms located in the south of Minas Gerais state, Brazil

    Directory of Open Access Journals (Sweden)

    Marcel Gomes Paixão

    Full Text Available ABSTRACT The objective of this study was to analyze the relationship between aspects related to financial management and scale of production with quality traits (total bacteria count - TBC; somatic cell count - SCC and composition (protein, fat, lactose, total solids, and non-fat solids of refrigerated bulk tank milk from 100 dairy farmers located in the south of Minas Gerais state, Brazil, by application of a semi-structured questionnaire. Dairy farmers were categorized according to the daily milk production: small (lower than 150 L; medium (151 to 500 L; and large (higher than 501 L. Chi-square tests and identification of possible relative risks between financial aspects and current regulation standards (Normative Instruction No. 62 of December 29, 2011, Ministry of Agriculture, Livestock and Supply associated to TBC (higher 300,000 CFU/mL and SCC (higher than 500,000 cells/mL means from bulk tank milk among different milk scales productions were performed. Bulk tanks milk composition met the legislation standards and had not differ between scales of production; however, SCC means within all scales, and TBC of small farmers had not attended the legislation standards and differences were identified (P ≤ 0.05. Regarding the financial management aspects, most farmers had no control over incomes, costs, nor calculated milk production cost, with decreased incidences as scale of production increased. Chi-square tests identified that producers that had no concern about milk quality payment bonuses had TBC means 2.95 times more likely (P ≤ 0.05 to be above the current regulations. Small dairy farmers had a greater negligence of the costs management and hygienic milk production as compared to medium and large farmers.

  16. Effect of overlapping on location of peaks in qualitative X-ray fluorescent analysis

    International Nuclear Information System (INIS)

    Jordanov, J.; Stefanov, R.; Tsanov, T.; Jordanov, N.

    1982-01-01

    To determine the location of the maxima in spectra without resorting to the comparatively complex Fourier-analysis apparatus it is proposed to take into account the overlapping of two adjacent peaks. A formula for the correction of the locations of overlapping maxima with an infinitely small step has been obtained and it is recommended when using X-ray apparatus with great resolution. With flat crystal-analyser apparata, which has a comparatively small resolution, a considerable number of maxima are obtained from the overlapping of at least two adjacent peaks. For that case another formula for the estimation of the shift of the maxima's location from their tabular values is proposed. (authors)

  17. method and container for production of diagnostic scanning agents

    International Nuclear Information System (INIS)

    Ruddock, C.F.

    1979-01-01

    The pertechnetate ion containing the technetium-99m isotope has limited applications in diagnostic scanning because it does not readily form complexes with materials which locate in specific parts of the body. Stannous salts have been widely used to reduce the pertechnetate to a form which readily complexes with materials. In the present invention, both a container and a more suitable metal reducing agent are discussed for transforming the technetium in pertechnetate for diagnostic scanning use. The vessel contains tin or a tin-containing alloy as a reducing agent for the pertechnetate and a complexant for the reduced technetium; all contents are sterile and dry. The present invention is advantageous over the stannous salts method since (1) problems of stannous salt instability during production, storage and after labelling are eliminated; (2) production procedures are simplified; (3) it is not essential to nitrogen purge vials before sterilisation; (4) it reduces toxicity; (5) the shelf life of diagnostic scanning kits may be dramatically improved; (6) the metal reducing agent may be sterilised by γ-irradiation without deteriorating; (7) the labelling technique can be performed over a wide pH range; and (8) the technique should be unaffected by technetium-99 in the technetium-99m. (U.K.)

  18. Removal of fission product ruthenium from purex process solutions: thiourea as complexing agent

    International Nuclear Information System (INIS)

    Floh, B.; Abrao, A.

    1980-01-01

    A new method for the treatment of spent uranium fuel is presented. It is based on the Purex Process using thiourea to increase the ruthenium decontamination factor. Thiourea exhibits a strong tendency for the formation of coordination compounds in acidic media. This tendency serves as a basis to transform nitrosyl-ruthenium species into Ru /SC(NH)(NH 2 )/ 2+ and Ru /SC(NH)(NH 2 )/ 3 complexes which are unextractable by TBP-varsol. The best conditions for the ruthenium-thiourea complex formation were found to be: thiourea-ruthenium ratio (mass/mass) close to 42, at 75 0 C, 30 minutes reaction time and aging period of 60 minutes. The ruthenium decontamination factor for a single uranium extraction are ca. 80-100, not interfering with extraction of actinides. These values are rather high in comparison to those obtained using the conventional Purex Process (e.g. F.D. sub(Ru)=10). By this reason the method developed here is suitable for the treatment of spent uranium fuels. Thiourea (100g/l) scrubbing experiments of ruthenium, partially co-extracted with actinides, confirmed the possibility of its removal from the extract. A decontamination greater than 83,5% for ruthenium as fission product is obtained in two stages with this procedure. (Author) [pt

  19. Problematisations of Complexity: On the Notion and Production of Diverse Complexities in Healthcare Interventions and Evaluations

    NARCIS (Netherlands)

    T. Broer (Tineke); R.A. Bal (Roland); Pickersgill, M. (Martyn)

    2017-01-01

    textabstractWithin the literature on the evaluation of health (policy) interventions, complexity is a much-debated issue. In particular, many claim that so-called ‘complex interventions’ pose different challenges to evaluation studies than apparently ‘simple interventions’ do. Distinct ways of doing

  20. Library Facility Siting and Location Handbook. The Greenwood Library Management Collection.

    Science.gov (United States)

    Koontz, Christine M.

    This handbook is a guide to the complex process of library facility siting and location. It includes relevant research and professionals' siting experiences, as well as actual case studies of closures, openings, mergers, and relocations of library facilities. While the bulk of the volume provides practical information, the work also presents an…

  1. Demonstration of the Robotic Gamma Locating and Isotopic Identification Device

    International Nuclear Information System (INIS)

    Anderson, M.O.; Conner, C.C.; Daniel, V.E.; McKay, M.D.; Yancey, N.A.

    2002-01-01

    The United States Department of Energy (DOE) continually seeks safer and more cost-effective technologies for use in decontaminating and decommissioning nuclear facilities. To this end, the Deactivation and Decommissioning Focus Area of DOE's Office of Science and Technology sponsors Large-Scale Demonstration and Deployment Projects (LSDDP) to test new technologies. As part of these projects, developers and vendors showcase new products designed to decrease health and safety risks to personnel and the environment, increase productivity, and lower costs. As part of the FY 2000 and 2001 LSDDP, the Idaho National Engineering and Environmental Laboratory (INEEL) collaborated with the Russian Research and Development Institute of Construction Technology (NIKIMT). This collaboration resulted in the development of the Robotic Gamma Locating and Isotopic Identification Device (RGL and IID) which integrated DOE Robotics Crosscutting (Rbx) technology with NIKIMT Russian gamma locating and isotopic identification technology. This paper will discuss the technologies involved in this integration and results from the demonstration including reduction of personnel exposure, increase in productivity, and reduced risk

  2. Production of complex multiantennary N-glycans in Nicotiana benthamiana plants.

    Science.gov (United States)

    Nagels, Bieke; Van Damme, Els J M; Pabst, Martin; Callewaert, Nico; Weterings, Koen

    2011-03-01

    In recent years, plants have been developed as an alternative expression system to mammalian hosts for the production of therapeutic proteins. Many modifications to the plant glycosylation machinery have been made to render it more human because of the importance of glycosylation for functionality, serum half-life, and the safety profile of the expressed proteins. These modifications include removal of plant-specific β1,2-xylose and core α1,3-fucose, and addition of bisecting N-acetylglucosamine, β1,4-galactoses, and sialic acid residues. Another glycosylation step that is essential for the production of complex human-type glycans is the synthesis of multiantennary structures, which are frequently found on human N-glycans but are not generated by wild-type plants. Here, we report both the magnICON-based transient as well as stable introduction of the α1,3-mannosyl-β1,4-N-acetylglucosaminyltransferase (GnT-IV isozymes a and b) and α1,6-mannosyl-β1,6-N-acetylglucosaminyltransferase (GnT-V) in Nicotiana benthamiana plants. The enzymes were targeted to the Golgi apparatus by fusing their catalytic domains to the plant-specific localization signals of xylosyltransferase and fucosyltransferase. The GnT-IV and -V modifications were tested in the wild-type background, but were also combined with the RNA interference-mediated knockdown of β1,2-xylosyltransferase and α1,3-fucosyltransferase. Results showed that triantennary Gn[GnGn] and [GnGn]Gn N-glycans could be produced according to the expected activities of the respective enzymes. Combination of the two enzymes by crossing stably transformed GnT-IV and GnT-V plants showed that up to 10% tetraantennary [GnGn][GnGn], 25% triantennary, and 35% biantennary N-glycans were synthesized. All transgenic plants were viable and showed no aberrant phenotype under standard growth conditions.

  3. Simple, complex and hyper-complex understanding - enhanced sensitivity in observation of information

    DEFF Research Database (Denmark)

    Bering Keiding, Tina

    for construction and analysis of empirical information. A quick overview on empirical research drawing on Luhmann reveals a diverse complex of analytical strategies and empirical methods. Despite differences between strategies and methods they have in common that understanding of uttered information is crucial...... in their production of empirically founded knowledge. However research generally seems to pay more attention to production of uttered information than to selection of understanding. The aim of this contribution is to sketch out a suggestion to how selection of understanding can be systematized in order to produce...... enhanced transparency in selection of understanding as well as enhanced sensitivity and definition in dept. The contribution suggest that we distinguish between three types of understanding; simple, complex and hyper-complex understanding. Simple understanding is the simultaneous selection of understanding...

  4. The Seis Lagos Carbonatite Complex

    International Nuclear Information System (INIS)

    Issler, R.S.; Silva, G.G. da.

    1980-01-01

    The Seis Lagos Carbonatite Complex located about 840 Km from Manaus, on the northwestern part of the Estado do Amazonas, Brazil is described. Geological reconnaissance mapping by Radam Project/DNPM, of the southwestern portion of the Guianes Craton, determined three circular features arranged in a north-south trend and outcroping as thick lateritic radioactive hills surrounded by gneisses and mignatites of the peneplained Guianense Complex. Results of core drilling samples analysis of the Seis Lagos Carbonatite Complex are compared with some igneous rocks and limestones of the world on the basis of abundance of their minor and trace elements. Log-log variation diagram of strontium and barium in carbonatite and limestone, exemplifield by South Africa and Angola carbonatites, are compared with the Seis Lagos Carbonatite Complex. The Seis Lagos Carbonatite Complex belongs to the siderite-soevite type. (E.G.) [pt

  5. International operations and location decisions: A firm-level approach

    NARCIS (Netherlands)

    Meijboom, Bert; Voordijk, Johannes T.

    2003-01-01

    The purpose of this study is to acquire a better understanding of why certain production and distribution facilities remain in Western Europe, in spite of economic globalisation. This paper focuses on companies located in the Netherlands but acting on an international scale. The issue is not

  6. The mitochondrial PHB complex: roles in mitochondrial respiratory complex assembly, ageing and degenerative disease.

    NARCIS (Netherlands)

    Nijtmans, L.G.J.; Artal-Sanz, M.; Grivell, L.A.; Coates, P.J.

    2002-01-01

    Although originally identified as putative negative regulators of the cell cycle, recent studies have demonstrated that the PHB proteins act as a chaperone in the assembly of subunits of mitochondrial respiratory chain complexes. The two PHB proteins, Phblp and Phb2p, are located in the

  7. A Framework for International Location Decisions for Manufacturing Firms Published in Production Engineering

    DEFF Research Database (Denmark)

    Schmidt, Andreas Strøjer Tynan; Touray, Ebou; Herbert-Hansen, Zaza Nadja Lee

    2017-01-01

    The purpose of this paper is to address current shortcomings in international location decisions (ILD), which were identified through an exploratory study, by developing a model that addresses previous limitations in research and encapsulate an adequate theories and frameworks. Based on insights ...

  8. Location of leaks in pressurized underground pipelines

    International Nuclear Information System (INIS)

    Eckert, E.G.; Maresca, J.W. Jr.

    1993-01-01

    Millions of underground storage tanks (UST) are used to store petroleum and other chemicals. The pressurized underground pipelines associated with USTs containing petroleum motor fuels are typically 2 in. in diameter and 50 to 200 ft in length. These pipelines typically operate at pressures of 20 to 30 psi. Longer lines, with diameters up to 4 in., are found in some high-volume facilities. There are many systems that can be used to detect leaks in pressurized underground pipelines. When a leak is detected, the first step in the remediation process is to find its location. Passive-acoustic measurements, combined with advanced signal-processing techniques, provide a nondestructive method of leak location that is accurate and relatively simple, and that can be applied to a wide variety of pipelines and pipeline products

  9. Manufacturing plant location selection in logistics network using Analytic Hierarchy Process

    Directory of Open Access Journals (Sweden)

    Ping-Yu Chang

    2015-11-01

    Full Text Available Purpose: In recent years, numerous companies have moved their manufacturing plants to China to capitalize on lower cost and tax. Plant location has such an impact on cost, stocks, and logistics network but location selection in the company is usually based on subjective preference of high ranking managers. Such a decision-making process might result in selecting a location with a lower fixed cost but a higher operational cost. Therefore, this research adapts real data from an electronics company to develop a framework that incorporates both quantitative and qualitative factors for selecting new plant locations. Design/methodology/approach: In-depth interviews were conducted with 12 high rank managers (7 of them are department manager, 2 of them are vice-president, 1 of them is senior engineer, and 2 of them are plant manager in the departments of construction, finance, planning, production, and warehouse to determine the important factors. A questionnaire survey is then conducted for comparing factors which are analyzed using the Analytic Hierarchy Process (AHP. Findings: Results show that the best location chosen by the developed framework coincides well with the company’s primal production base. The results have been presented to the company’s high ranking managers for realizing the accuracy of the framework. Positive responses of the managers indicate usefulness of implementing the proposed model into reality, which adds to the value of this research. Practical implications: The proposed framework can save numerous time-consuming meetings called to compromise opinions and conflictions from different departments in location selection. Originality/value: This paper adapts the Analytic Hierarchy Process (AHP to incorporate quantitative and qualitative factors which are obtained through in-depth interviews with high rank managers in a company into the location decision.

  10. The Y-12 National Security Complex Foreign Research Reactor Uranium Supply Production

    Energy Technology Data Exchange (ETDEWEB)

    Nelson, T. [Nuclear Technology and Nonproliferation Programs, B and W Y-12, L.L.C., Y-12 National Security Complex, Oak Ridge, Tennessee (United States); Keller, A.P. [Disposition and Supply Programs, B and W Y-12, L.L.C., Y-12 National Security Complex, Oak Ridge, Tennessee (United States)

    2011-07-01

    The Foreign Research Reactor (FRR) Uranium Supply Program at the Y-12 National Security Complex supports the nonproliferation objectives of the National Nuclear Security Administration (NNSA) HEU Disposition, the Reduced Enrichment Research and Test Reactors (RERTR), and the United States (U.S.) FRR Spent Nuclear Fuel (SNF) Acceptance Programs. The FRR Supply Program supports the important U.S. government nuclear nonproliferation commitment to serve as a reliable and cost-effective uranium supplier for those foreign research reactors that are converting or have converted to Low-Enriched Uranium (LEU) fuel under the RERTR Program. The NNSA Y-12 Site Office maintains the prime contracts with foreign government agencies for the supply of LEU for their research reactors. The LEU is produced by down blending Highly Enriched Uranium (HEU) that has been declared surplus to the U.S. national defense needs. The down blending and sale of the LEU supports the Surplus HEU Disposition Program Record of Decision to make the HEU non-weapons usable and to recover the economic value of the uranium to the extent feasible. In addition to uranium metal feedstock for fuel fabrication, Y-12 can produce LEU in different forms to support new fuel development or target fabrication for medical isotope production. With production improvements and efficient delivery preparations, Y-12 continues to successfully support the global research reactor community. (author)

  11. Octopus vulgaris uses visual information to determine the location of its arm.

    Science.gov (United States)

    Gutnick, Tamar; Byrne, Ruth A; Hochner, Binyamin; Kuba, Michael

    2011-03-22

    Octopuses are intelligent, soft-bodied animals with keen senses that perform reliably in a variety of visual and tactile learning tasks. However, researchers have found them disappointing in that they consistently fail in operant tasks that require them to combine central nervous system reward information with visual and peripheral knowledge of the location of their arms. Wells claimed that in order to filter and integrate an abundance of multisensory inputs that might inform the animal of the position of a single arm, octopuses would need an exceptional computing mechanism, and "There is no evidence that such a system exists in Octopus, or in any other soft bodied animal." Recent electrophysiological experiments, which found no clear somatotopic organization in the higher motor centers, support this claim. We developed a three-choice maze that required an octopus to use a single arm to reach a visually marked goal compartment. Using this operant task, we show for the first time that Octopus vulgaris is capable of guiding a single arm in a complex movement to a location. Thus, we claim that octopuses can combine peripheral arm location information with visual input to control goal-directed complex movements. Copyright © 2011 Elsevier Ltd. All rights reserved.

  12. Surface Environmental Surveillance Project: Locations Manual Volume 1 – Air and Water Volume 2 – Farm Products, Soil & Vegetation, and Wildlife

    Energy Technology Data Exchange (ETDEWEB)

    Fritz, Brad G.; Patton, Gregory W.; Stegen, Amanda; Poston, Ted M.

    2009-01-01

    This report describes all environmental monitoring locations associated with the Surface Environmental Surveillance Project. Environmental surveillance of the Hanford site and surrounding areas is conducted by the Pacific Northwest National Laboratory (PNNL) for the U.S. Department of Energy (DOE). Sampling is conducted to evaluate levels of radioactive and nonradioactive pollutants in the Hanford environs, as required in DOE Order 450.1, Environmental Protection Program, and DOE Order 5400.5, Radiation Protection of the Public and the Environment. The environmental surveillance sampling design is described in the Hanford Site Environmental Monitoring Plan, United States Department of Energy, Richland Operation Office (DOE/RL-91-50). This document contains the locations of sites used to collect samples for the Surface Environmental Surveillance Project (SESP). Each section includes directions, maps, and pictures of the locations. A general knowledge of roads and highways on and around the Hanford Site is necessary to successfully use this manual. Supplemental information (Maps, Gazetteer, etc.) may be necessary if user is unfamiliar with local routes. The SESP is a multimedia environmental surveillance effort to measure the concentrations of radionuclides and chemicals in environmental media to demonstrate compliance with applicable environmental quality standards and public exposure limits, and assessing environmental impacts. Project personnel annually collect selected samples of ambient air, surface water, agricultural products, fish, wildlife, and sediments. Soil and vegetation samples are collected approximately every 5 years. Analytical capabilities include the measurement of radionuclides at very low environmental concentrations and, in selected media, nonradiological chemicals including metals, anions, volatile organic compounds, and total organic carbon.

  13. Poles of the S matrix for a complex potential

    International Nuclear Information System (INIS)

    Dabrowski, J.

    1996-01-01

    Trajectories of S matrix poles in complex k plane are presented for a complex square well potential. A simple rule is given for predicting the effect of an absorptive potential on the location of these poles. copyright 1996 The American Physical Society

  14. A stable isotope approach for source apportionment of chlorinated ethene plumes at a complex multi-contamination events urban site

    Science.gov (United States)

    Nijenhuis, Ivonne; Schmidt, Marie; Pellegatti, Eleonora; Paramatti, Enrico; Richnow, Hans Hermann; Gargini, Alessandro

    2013-10-01

    The stable carbon isotope composition of chlorinated aliphatic compounds such as chlorinated methanes, ethanes and ethenes was examined as an intrinsic fingerprint for apportionment of sources. A complex field site located in Ferrara (Italy), with more than 50 years history of use of chlorinated aliphatic compounds, was investigated in order to assess contamination sources. Several contamination plumes were found in a complex alluvial sandy multi-aquifer system close to the river Po; sources are represented by uncontained former industrial and municipal dump sites as well as by spills at industrial areas. The carbon stable isotope signature allowed distinguishing 2 major sources of contaminants. One source of chlorinated aliphatic contaminants was strongly depleted in 13C (-40‰ which is commonly observed in recent production of chlorinated solvents. The degradation processes in the plumes could be traced interpreting the isotope enrichment and depletion of parent and daughter compounds, respectively. We demonstrate that, under specific production conditions, namely when highly chlorinated ethenes are produced as by-product during chloromethanes production, 13C depleted fingerprinting of contaminants can be obtained and this can be used to track sources and address the responsible party of the pollution in urban areas.

  15. Ab Initio investigation of chloroaqualead (II) complexes as possible corrosion products in Super Critical Water Cooled Reactor (SCWR)

    Energy Technology Data Exchange (ETDEWEB)

    Anzelj, D.; Pye, C.C., E-mail: diki1979@hotmail.com, E-mail: cory.pye@smu.ca [Saint Mary' s University, Halifax, NS (Canada)

    2015-07-01

    One of the undesirable processes hindering development of Generation IV SCWR is the possibility of corrosion of construction material. Formation of corrosion products such as metal-ligand complexes is poorly understood both experimentally and computationally. It is essential to predict and control its water chemistry to ensure sustainability of SCWR. Pressurized and heated solutions are challenging for experimental research; computational method becomes an important research tool. A series of ab initio calculations of chloroaqualead (II) complexes have been performed at HF, MP2 and B3LYP levels of theory with CEP-121G, LANL2DZ, SDD basis sets for Pb and 6-31G*, 6-31+G*, 6-311+G* for water. (author)

  16. Ab Initio investigation of chloroaqualead (II) complexes as possible corrosion products in Super Critical Water Cooled Reactor (SCWR)

    International Nuclear Information System (INIS)

    Anzelj, D.; Pye, C.C.

    2015-01-01

    One of the undesirable processes hindering development of Generation IV SCWR is the possibility of corrosion of construction material. Formation of corrosion products such as metal-ligand complexes is poorly understood both experimentally and computationally. It is essential to predict and control its water chemistry to ensure sustainability of SCWR. Pressurized and heated solutions are challenging for experimental research; computational method becomes an important research tool. A series of ab initio calculations of chloroaqualead (II) complexes have been performed at HF, MP2 and B3LYP levels of theory with CEP-121G, LANL2DZ, SDD basis sets for Pb and 6-31G*, 6-31+G*, 6-311+G* for water. (author)

  17. Survey Report For The Characterization Of The Five Tanks Located Near The Old Salvage Yard At The Y-12 National Security Complex, Oak Ridge, Tennessee

    International Nuclear Information System (INIS)

    Rollow, Kathy

    2012-01-01

    This summary report presents analytical results, radiological survey data, and other data/information for disposition planning of the five tanks located west of the Old Salvage Yard (OSY) at the Y-12 National Security Complex (Y-12) in Oak Ridge, Tennessee. Field personnel from Oak Ridge Associated Universities (ORAU) and URS-CH2M Oak Ridge LLC completed data collection in May 2012 per the project-specific plan (PSP) (ORAU 2012). Deviations from the PSP are addressed in the body of this report. Characterization activities included three data collection modes: visual inspection, radiological survey, and volumetric sampling/analysis. This report includes the final validated dataset and updates associated with the Tank 2 residues originally thought to be a biological bloom (e.g., slime mold) but ultimately identified as iron sulfate crystals

  18. Nuclear weapons complex

    International Nuclear Information System (INIS)

    Rezendes, V.S.

    1991-03-01

    In this book, GAO characterizes DOE's January 1991 Nuclear Weapons Complex Reconfiguration Study as a starting point for reaching agreement on solutions to many of the complex's safety and environmental problems. Key decisions still need to be made about the size of the complex, where to relocate plutonium operations, what technologies to use for new tritium production, and what to do with excess plutonium. The total cost for reconfiguring and modernizing the complex is still uncertain, and some management issues remain unresolved. Congress faces a difficult task in making test decisions given the conflicting demands for scarce resources in a time of growing budget deficits and war in the Persian Gulf

  19. Crystal structure of the enzyme-product complex reveals sugar ring distortion during catalysis by family 63 inverting α-glycosidase.

    Science.gov (United States)

    Miyazaki, Takatsugu; Nishikawa, Atsushi; Tonozuka, Takashi

    2016-12-01

    Glycoside hydrolases are divided into two groups, known as inverting and retaining enzymes, based on their hydrolytic mechanisms. Glycoside hydrolase family 63 (GH63) is composed of inverting α-glycosidases, which act mainly on α-glucosides. We previously found that Escherichia coli GH63 enzyme, YgjK, can hydrolyze 2-O-α-d-glucosyl-d-galactose. Two constructed glycosynthase mutants, D324N and E727A, which catalyze the transfer of a β-glucosyl fluoride donor to galactose, lactose, and melibiose. Here, we determined the crystal structures of D324N and E727A soaked with a mixture of glucose and lactose at 1.8- and 2.1-Å resolutions, respectively. Because glucose and lactose molecules are found at the active sites in both structures, it is possible that these structures mimic the enzyme-product complex of YgjK. A glucose molecule found at subsite -1 in both structures adopts an unusual 1 S 3 skew-boat conformation. Comparison between these structures and the previously determined enzyme-substrate complex structure reveals that the glucose pyranose ring might be distorted immediately after nucleophilic attack by a water molecule. These structures represent the first enzyme-product complex for the GH63 family, as well as the structurally-related glycosidases, and it may provide insight into the catalytic mechanism of these enzymes. Copyright © 2016 Elsevier Inc. All rights reserved.

  20. Potential bioethanol feedstock availability around nine locations in the Republic of Ireland

    International Nuclear Information System (INIS)

    Deverell, R.; McDonnell, K.; Devlin, G.

    2009-01-01

    The Republic of Ireland, like many other countries is trying to diversify energy sources to counteract environmental, political and social concerns. Bioethanol from domestically grown agricultural crops is an indigenously produced alternative fuel that can potentially go towards meeting the goal of diversified energy supply. The Republic of Ireland's distribution of existing soils and agricultural land-uses limit arable crop land to around 10% of total agricultural area. Demand for land to produce arable crops is expected to decrease, which could open the opportunity for bioethanol production. Bioethanol production plants are required to be of a sufficient scale in order to compete economically with other fuel sources, it is important therefore to determine if enough land exists around potential ethanol plant locations to meet the potential demands for feedstock. This study determines, through the use of a developed GIS based model, the potential quantities of feedstock that is available in the hinterlands of nine locations in the Republic of Ireland. The results indicate that three locations can meet all its feedstock demands using indigenously grown sugarbeet, while only one location can meet its demands using a combination of indigenous wheat and straw as the two locally sourced feedstocks. (author)

  1. Commercial milk distribution profiles and production locations. Hanford Environmental Dose Reconstruction Project

    Energy Technology Data Exchange (ETDEWEB)

    Deonigi, D.E.; Anderson, D.M.; Wilfert, G.L.

    1994-04-01

    The Hanford Environmental Dose Reconstruction (HEDR) Project was established to estimate radiation doses that people could have received from nuclear operations at the Hanford Site since 1944. For this period iodine-131 is the most important offsite contributor to radiation doses from Hanford operations. Consumption of milk from cows that ate vegetation contaminated by iodine-131 is the dominant radiation pathway for individuals who drank milk (Napier 1992). Information has been developed on commercial milk cow locations and commercial milk distribution during 1945 and 1951. The year 1945 was selected because during 1945 the largest amount of iodine-131 was released from Hanford facilities in a calendar year (Heeb 1993); therefore, 1945 was the year in which an individual was likely to have received the highest dose. The year 1951 was selected to provide data for comparing the changes that occurred in commercial milk flows (i.e., sources, processing locations, and market areas) between World War II and the post-war period. To estimate the doses people could have received from this milk flow, it is necessary to estimate the amount of milk people consumed, the source of the milk, the specific feeding regime used for milk cows, and the amount of iodine-131 contamination deposited on feed.

  2. TRLIFS study of Eu(III) spectroscopic properties to obtain structural and thermodynamic informations on lanthanide-malonamide complexes in the Eu(III)/NaNO3/tetraethylmalonamide system

    International Nuclear Information System (INIS)

    Couston, L.; Charbonnel, M.C.; Flandin, J.L.; Rancier, F.; Moulin, C.

    2004-01-01

    Improvement of the nuclear fuel reprocessing involves separating the minor actinides (Am(III) and Cm(III)) from the fission products. In the French strategy, the first step consists in the separation of the trivalent actinides and lanthanides from high-level liquid waste, for which malonamides RR'NCO(CHR '' )CONRR' are promising ligands. These molecules have been optimized for reprocessing but still require basic chemical studies to describe the complexation mechanisms at a molecular scale. This paper discusses a thermodynamic and structural study of a Ln(III)-malonamide complex formed with the hydrosoluble tetraethylmalonamide ligand (TEMA = (C 2 H 5 ) 2 NCOCH 2 CON(C 2 H 5 ) 2 ) dissolved in a nitrate medium. Despite the simplified chemical system obtained with TEMA, its weak chemical affinity and its physical properties pushed the analytical techniques to their limits. The sensitivity of time-resolved laser-induced fluorescence spectroscopy (TRLIFS) combined with the major luminescent spectroscopic properties of Eu(III) (hypersensitive band and fluorescence lifetime) were successfully used to determine the equilibrium constant and hydration number in the Eu(III), TEMA, and NO 3 - system. Fluorescence lifetimes, connected with the first coordination sphere of the solvated metal, clearly show the inner-sphere location of nitrate in the Eu(NO 3 ) 2+ complex, the outer-sphere location of TEMA in the Eu(TEMA) 3+ complex, and the outer-sphere location of both ligands in the Eu(NO 3 )(TEMA) 2+ complex. (orig.)

  3. An Integrated Assessment of Location-Dependent Scaling for Microalgae Biofuel Production Facilities

    Energy Technology Data Exchange (ETDEWEB)

    Coleman, Andre M.; Abodeely, Jared; Skaggs, Richard; Moeglein, William AM; Newby, Deborah T.; Venteris, Erik R.; Wigmosta, Mark S.

    2014-06-19

    Successful development of a large-scale microalgae-based biofuels industry requires comprehensive analysis and understanding of the feedstock supply chain—from facility siting/design through processing/upgrading of the feedstock to a fuel product. The evolution from pilot-scale production facilities to energy-scale operations presents many multi-disciplinary challenges, including a sustainable supply of water and nutrients, operational and infrastructure logistics, and economic competitiveness with petroleum-based fuels. These challenges are addressed in part by applying the Integrated Assessment Framework (IAF)—an integrated multi-scale modeling, analysis, and data management suite—to address key issues in developing and operating an open-pond facility by analyzing how variability and uncertainty in space and time affect algal feedstock production rates, and determining the site-specific “optimum” facility scale to minimize capital and operational expenses. This approach explicitly and systematically assesses the interdependence of biofuel production potential, associated resource requirements, and production system design trade-offs. The IAF was applied to a set of sites previously identified as having the potential to cumulatively produce 5 billion-gallons/year in the southeastern U.S. and results indicate costs can be reduced by selecting the most effective processing technology pathway and scaling downstream processing capabilities to fit site-specific growing conditions, available resources, and algal strains.

  4. Communication complexity and information complexity

    Science.gov (United States)

    Pankratov, Denis

    complexity of two of the most studied functions in the communication complexity literature: Gap Hamming Distance (GHD) and Inner Product mod 2 (IP). In our first result we affirm the conjecture that the information complexity of GHD is linear even under the uniform distribution. This strengthens the O(n) bound shown by Kerenidis et al. (2012) and answers an open problem by Chakrabarti et al. (2012). We also prove that the information complexity of IP is arbitrarily close to the trivial upper bound n as the permitted error tends to zero, again strengthening the O(n) lower bound proved by Braverman and Weinstein (2011). More importantly, our proofs demonstrate that self-reducibility makes the connection between information complexity and communication complexity lower bounds a two-way connection. Whereas numerous results in the past used information complexity techniques to derive new communication complexity lower bounds, we explore a generic way, in which communication complexity lower bounds imply information complexity lower bounds in a black-box manner. In the third contribution we consider the roles that private and public randomness play in the definition of information complexity. In communication complexity, private randomness can be trivially simulated by public randomness. Moreover, the communication cost of simulating public randomness with private randomness is well understood due to Newman's theorem (1991). In information complexity, the roles of public and private randomness are reversed: public randomness can be trivially simulated by private randomness. However, the information cost of simulating private randomness with public randomness is not understood. We show that protocols that use only public randomness admit a rather strong compression. In particular, efficient simulation of private randomness by public randomness would imply a version of a direct sum theorem in the setting of communication complexity. This establishes a yet another connection between

  5. A System for Complex Robotic Welding

    DEFF Research Database (Denmark)

    Madsen, Ole; Sørensen, Carsten Bro; Olsen, Birger

    2002-01-01

    This paper presents the architecture of a system for robotic welding of complex tasks. The system integrates off-line programming, control of redundant robots, collision-free motion planning and sensor-based control. An implementation for pipe structure welding made at Odense Steel Shipyard Ltd......., Denmark, demonstrates the system can be used for automatic welding of complex products in one-of-a-kind production....

  6. Competition and the Location of Overseas Assembly

    OpenAIRE

    Deborah Swenson

    2006-01-01

    How does international competition affect overseas outsourcing? While it is commonly believed that international competition enables firms to desert high cost countries in favor of low wage locations, the frequency of such responses may be reduced if the movement of outsourcing activities involves sunk costs. To put these factors in perspective, I study the production decisions of participants in the U.S. overseas assembly program (OAP). A number of interesting regularities emerge. First, the...

  7. Variation in Location of the Mandibular Foramen/Inferior Alveolar Nerve Complex Given Anatomic Landmarks Using Cone-beam Computed Tomographic Scans.

    Science.gov (United States)

    Blacher, Jonathan; Van DaHuvel, Scott; Parashar, Vijay; Mitchell, John C

    2016-03-01

    The inferior alveolar nerve (IAN) injection is 1 of the most commonly administered and useful injections in the field of dentistry. Practitioners use intraoral anatomic landmarks, which vary greatly among patients. The objective of this study was to assist practitioners by identifying a range of normal variability within certain landmarks used in delivering IAN anesthesia. A total of 203 randomly selected retrospective cone-beam computed tomographic scans were obtained from the Midwestern University Dental Institute cone-beam computed tomographic database. InVivoDental5.0 volumetric imaging software (Anatomage, San Jose, CA) was used to measure 2 important parameters used in locating the mandibular foramen (MF)/IAN complex: (1) the angle from the contralateral premolar contact area to the MF and (2) the distance above the mandibular occlusal plane to the center of the MF. The variation of these measurements was compared with established reference values and statistically analyzed using a 1-sample t test. The angle from the contralateral premolar contact area to the MF for the right and left sides was 42.99° and 42.57°, respectively. The angulations varied significantly from the reference value of 45° (P < .001). The minimum height above the mandibular occlusal plane for the right and left sides was 9.85 mm and 9.81 mm, respectively. The heights varied significantly from the minimum reference value of 6 mm but not the maximum reference value of 10 mm (P < .001). Orienting the syringe barrel at an angulation slightly less than 45° and significantly higher than 6 mm above the mandibular occlusal plane can aid in successfully administering anesthesia to the MF/IAN complex. Copyright © 2016 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.

  8. Lost in Location

    DEFF Research Database (Denmark)

    Hansen, Lone Koefoed

    2009-01-01

    traversed. While becoming destination aware, the individual loses her location awareness. The article proposes that the reason people get lost when using sat-nav is due to a wrong location-performative paradigm. As an alternative, the article introduces and analyzes two performance-related examples...... that illustrate an alternative location-performative paradigm: Meredith Warner's Lost/Found knitting series and Etter and Schecht's Melodious Walkabout. In both examples, the artist's hand becomes the intermediary between alien and location. Thus, by exploring how wayfinding can be a poetically situated...... performance, the article examines how the growing locative media industry can learn from the location-aware performative strategies employed by artists who create situated and urban performances for the curious participant. The academic frames employed in the analysis draw on psychogeography, site...

  9. Protein (multi-)location prediction: using location inter-dependencies in a probabilistic framework

    Science.gov (United States)

    2014-01-01

    Motivation Knowing the location of a protein within the cell is important for understanding its function, role in biological processes, and potential use as a drug target. Much progress has been made in developing computational methods that predict single locations for proteins. Most such methods are based on the over-simplifying assumption that proteins localize to a single location. However, it has been shown that proteins localize to multiple locations. While a few recent systems attempt to predict multiple locations of proteins, their performance leaves much room for improvement. Moreover, they typically treat locations as independent and do not attempt to utilize possible inter-dependencies among locations. Our hypothesis is that directly incorporating inter-dependencies among locations into both the classifier-learning and the prediction process can improve location prediction performance. Results We present a new method and a preliminary system we have developed that directly incorporates inter-dependencies among locations into the location-prediction process of multiply-localized proteins. Our method is based on a collection of Bayesian network classifiers, where each classifier is used to predict a single location. Learning the structure of each Bayesian network classifier takes into account inter-dependencies among locations, and the prediction process uses estimates involving multiple locations. We evaluate our system on a dataset of single- and multi-localized proteins (the most comprehensive protein multi-localization dataset currently available, derived from the DBMLoc dataset). Our results, obtained by incorporating inter-dependencies, are significantly higher than those obtained by classifiers that do not use inter-dependencies. The performance of our system on multi-localized proteins is comparable to a top performing system (YLoc+), without being restricted only to location-combinations present in the training set. PMID:24646119

  10. Protein (multi-)location prediction: using location inter-dependencies in a probabilistic framework.

    Science.gov (United States)

    Simha, Ramanuja; Shatkay, Hagit

    2014-03-19

    Knowing the location of a protein within the cell is important for understanding its function, role in biological processes, and potential use as a drug target. Much progress has been made in developing computational methods that predict single locations for proteins. Most such methods are based on the over-simplifying assumption that proteins localize to a single location. However, it has been shown that proteins localize to multiple locations. While a few recent systems attempt to predict multiple locations of proteins, their performance leaves much room for improvement. Moreover, they typically treat locations as independent and do not attempt to utilize possible inter-dependencies among locations. Our hypothesis is that directly incorporating inter-dependencies among locations into both the classifier-learning and the prediction process can improve location prediction performance. We present a new method and a preliminary system we have developed that directly incorporates inter-dependencies among locations into the location-prediction process of multiply-localized proteins. Our method is based on a collection of Bayesian network classifiers, where each classifier is used to predict a single location. Learning the structure of each Bayesian network classifier takes into account inter-dependencies among locations, and the prediction process uses estimates involving multiple locations. We evaluate our system on a dataset of single- and multi-localized proteins (the most comprehensive protein multi-localization dataset currently available, derived from the DBMLoc dataset). Our results, obtained by incorporating inter-dependencies, are significantly higher than those obtained by classifiers that do not use inter-dependencies. The performance of our system on multi-localized proteins is comparable to a top performing system (YLoc+), without being restricted only to location-combinations present in the training set.

  11. Is a "Complex" Task Really Complex? Validating the Assumption of Cognitive Task Complexity

    Science.gov (United States)

    Sasayama, Shoko

    2016-01-01

    In research on task-based learning and teaching, it has traditionally been assumed that differing degrees of cognitive task complexity can be inferred through task design and/or observations of differing qualities in linguistic production elicited by second language (L2) communication tasks. Without validating this assumption, however, it is…

  12. Logistics Solution for Choosing Location of Production of Road Construction Enterprise

    Science.gov (United States)

    Gavrilina, I.; Bondar, A.

    2017-11-01

    The current state of construction of highways indicates that not all the resources of the construction organization are implemented and supported by the modern approaches in logistics problems solving. This article deals with the solution of these problems and considers the features of basic road linear works organization, their large extent and different locations of enterprises. Analyzing these data, it is proposed to simulate the logistics processes and substantiate the methods of transport operations organizing by linking the technology and the organization road construction materials delivery which allows one to optimize the construction processes, to choose the most economically advantageous options, and also to monitor the quality of work.

  13. Quarter Dates Location(s) Purpose Transportation and Travel ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    IDRC CRDI

    Dates. Location(s). Purpose. Transportation and Travel. Accommodation,. Meals and Other. Hospitality. Total. Expenses. Quarter 1. May 15. Ottawa, ON. Meetings. May 20 to 21. Washington DC. Conference. 11,364.93. 3,274.71. 53.50. 14,693.14. May 5 to June 5. Kenya and England. Meetings. June 18 to 21. Winnipeg, MB.

  14. Nitric oxide production by visible light irradiation of aqueous solution of nitrosyl ruthenium complexes.

    Science.gov (United States)

    Sauaia, Marília Gama; de Lima, Renata Galvão; Tedesco, Antonio Claudio; da Silva, Roberto Santana

    2005-12-26

    [Ru(II)L(NH(3))(4)(pz)Ru(II)(bpy)(2)(NO)](PF(6))(5) (L is NH(3), py, or 4-acpy) was prepared with good yields in a straightforward way by mixing an equimolar ratio of cis-[Ru(NO(2))(bpy)(2)(NO)](PF(6))(2), sodium azide (NaN(3)), and trans-[RuL(NH(3))(4)(pz)] (PF(6))(2) in acetone. These binuclear compounds display nu(NO) at ca. 1945 cm(-)(1), indicating that the nitrosyl group exhibits a sufficiently high degree of nitrosonium ion (NO(+)). The electronic spectrum of the [Ru(II)L(NH(3))(4)(pz)Ru(II)(bpy)(2)(NO)](5+) complex in aqueous solution displays the bands in the ultraviolet and visible regions typical of intraligand and metal-to-ligand charge transfers, respectively. Cyclic voltammograms of the binuclear complexes in acetonitrile give evidence of three one-electron redox processes consisting of one oxidation due to the Ru(2+/3+) redox couple and two reductions concerning the nitrosyl ligand. Flash photolysis of the [Ru(II)L(NH(3))(4)(pz)Ru(II)(bpy)(2)(NO)](5+) complex is capable of releasing nitric oxide (NO) upon irradiation at 355 and 532 nm. NO production was detected and quantified by an amperometric technique with a selective electrode (NOmeter). The irradiation at 532 nm leads to NO release as a consequence of a photoinduced electron transfer. All species exhibit similar photochemical behavior, a feature that makes their study extremely important for their future application in the upgrade of photodynamic therapy in living organisms.

  15. i-Locate - Indoor/Outdoor location and Asset Management through Open Data

    Directory of Open Access Journals (Sweden)

    Claudio Eccher

    2015-02-01

    Full Text Available Studi recenti hanno evidenziato che, in media, trascorriamo circa il 90% del nostro tempo in ambienti chiusi e, spesso, non familiari. L’esigenza di localizzare/guidare persone o ogg etti in spazi sia esterni che interni (senza discontinuità tra esterno ed interno darà origine ad una serie di nuovi servizi di tipo LBS (Location-Based Services che potranno avere anche una notevole rilevanza economica. i-locate (Indoor / outdoor location and Asset Management Through open geodata is a project that aims to develop a set of tools and services based on geo location technologies based on open data for the location and management of objects in indoor and outdoor spaces. The tools are intended both to citizens who use their smartphones to access services, aids to navigation from the front door to internal destinations to buildings (public office, clinic, shop, etc.. Obtaining any information available to support (code , unforeseen changes in the path, suggestions, etc., and professionals for specific activities that require the location of people, equipment, etc. i-locate to an intense use of GIS technologies for navigation and tracking "indoor" (indoor GIS, 3D GIS, to locate people (eg. Alzheimer's patients and their movements in areas not suited (geofencing to identify and track objects / portable equipment for their location, management and maintenance.

  16. i-Locate - Indoor/Outdoor location and Asset Management through Open Data

    Directory of Open Access Journals (Sweden)

    Claudio Eccher

    2015-02-01

    Full Text Available Studi recenti hanno evidenziato che, in media, trascorriamo circa il 90% del nostro tempo in ambienti chiusi e, spesso, non familiari. L’esigenza di localizzare/guidare persone o ogg etti in spazi sia esterni che interni (senza discontinuità tra esterno ed interno darà origine ad una serie di nuovi servizi di tipo LBS (Location-Based Services che potranno avere anche una notevole rilevanza economica.i-locate (Indoor / outdoor location and Asset Management Through open geodata is a project that aims to develop a set of tools and services based on geo location technologies based on open data for the location and management of objects in indoor and outdoor spaces. The tools are intended both to citizens who use their smartphones to access services, aids to navigation from the front door to internal destinations to buildings (public office, clinic, shop, etc.. Obtaining any information available to support (code , unforeseen changes in the path, suggestions, etc., and professionals for specific activities that require the location of people, equipment, etc. i-locate to an intense use of GIS technologies for navigation and tracking "indoor" (indoor GIS, 3D GIS, to locate people (eg. Alzheimer's patients and their movements in areas not suited (geofencing to identify and track objects / portable equipment for their location, management and maintenance.

  17. Mechanistic insights into validoxylamine A 7'-phosphate synthesis by VldE using the structure of the entire product complex.

    Directory of Open Access Journals (Sweden)

    Michael C Cavalier

    Full Text Available The pseudo-glycosyltransferase VldE catalyzes non-glycosidic C-N coupling between an unsaturated cyclitol and a saturated aminocyclitol with the conservation of the stereochemical configuration of the substrates to form validoxylamine A 7'-phosphate, the biosynthetic precursor of the antibiotic validamycin A. To study the molecular basis of its mechanism, the three-dimensional structures of VldE from Streptomyces hygroscopicus subsp. limoneus was determined in apo form, in complex with GDP, in complex with GDP and validoxylamine A 7'-phosphate, and in complex with GDP and trehalose. The structure of VldE with the catalytic site in both an "open" and "closed" conformation is also described. With these structures, the preferred binding of the guanine moiety by VldE, rather than the uracil moiety as seen in OtsA could be explained. The elucidation of the VldE structure in complex with the entirety of its products provides insight into the internal return mechanism by which catalysis occurs with a net retention of the stereochemical configuration of the donated cyclitol.

  18. Microseismic event location by master-event waveform stacking

    Science.gov (United States)

    Grigoli, F.; Cesca, S.; Dahm, T.

    2016-12-01

    Waveform stacking location methods are nowadays extensively used to monitor induced seismicity monitoring assoiciated with several underground industrial activities such as Mining, Oil&Gas production and Geothermal energy exploitation. In the last decade a significant effort has been spent to develop or improve methodologies able to perform automated seismological analysis for weak events at a local scale. This effort was accompanied by the improvement of monitoring systems, resulting in an increasing number of large microseismicity catalogs. The analysis of microseismicity is challenging, because of the large number of recorded events often characterized by a low signal-to-noise ratio. A significant limitation of the traditional location approaches is that automated picking is often done on each seismogram individually, making little or no use of the coherency information between stations. In order to improve the performance of the traditional location methods, in the last year, alternative approaches have been proposed. These methods exploits the coherence of the waveforms recorded at different stations and do not require any automated picking procedure. The main advantage of this methods relies on their robustness even when the recorded waveforms are very noisy. On the other hand, like any other location method, the location performance strongly depends on the accuracy of the available velocity model. When dealing with inaccurate velocity models, in fact, location results can be affected by large errors. Here we will introduce a new automated waveform stacking location method which is less dependent on the knowledge of the velocity model and presents several benefits, which improve the location accuracy: 1) it accounts for phase delays due to local site effects, e.g. surface topography or variable sediment thickness 2) theoretical velocity model are only used to estimate travel times within the source volume, and not along the whole source-sensor path. We

  19. Complex Formation by the mrpABCDEFG Gene Products, Which Constitute a Principal Na+/H+ Antiporter in Bacillus subtilis▿

    OpenAIRE

    Kajiyama, Yusuke; Otagiri, Masato; Sekiguchi, Junichi; Kosono, Saori; Kudo, Toshiaki

    2007-01-01

    The Bacillus subtilis Mrp (also referred to as Sha) is a particularly unusual Na+/H+ antiporter encoded by mrpABCDEFG. Using His tagging of Mrp proteins, we showed complex formation by the mrpABCDEFG gene products by pull-down and blue native polyacrylamide gel electrophoresis analyses. This is the first molecular evidence that the Mrp is a multicomponent antiporter in the cation-proton antiporter 3 family.

  20. Locative media and data-driven computing experiments

    Directory of Open Access Journals (Sweden)

    Sung-Yueh Perng

    2016-06-01

    Full Text Available Over the past two decades urban social life has undergone a rapid and pervasive geocoding, becoming mediated, augmented and anticipated by location-sensitive technologies and services that generate and utilise big, personal, locative data. The production of these data has prompted the development of exploratory data-driven computing experiments that seek to find ways to extract value and insight from them. These projects often start from the data, rather than from a question or theory, and try to imagine and identify their potential utility. In this paper, we explore the desires and mechanics of data-driven computing experiments. We demonstrate how both locative media data and computing experiments are ‘staged’ to create new values and computing techniques, which in turn are used to try and derive possible futures that are ridden with unintended consequences. We argue that using computing experiments to imagine potential urban futures produces effects that often have little to do with creating new urban practices. Instead, these experiments promote Big Data science and the prospect that data produced for one purpose can be recast for another and act as alternative mechanisms of envisioning urban futures.

  1. Effects of a wax organogel and alginate gel complex on holy basil (Ocimum sanctum) in vitro ruminal dry matter disappearance and gas production.

    Science.gov (United States)

    Templeman, James R; Rogers, Michael A; Cant, John P; McBride, Brian W; Osborne, Vern R

    2018-02-20

    The objectives of this study were to: (a) select an ideal organogel for the oil phase of a novel gel encapsulation technology, (b) optimize the formulation of an organogel and sodium alginate-based gel complex, and (c) examine the rumen protective ability of the gel by measuring 48-h in vitro ruminal dry matter disappearance and gas production from encapsulated dried and ground holy basil leaves. A rice-bran wax and canola oil organogel was selected for the oil phase of the gel complex as this combination had a 48-h dry matter disappearance of 6%, the lowest of all organogels analyzed. The gel complex was formulated by homogenizing the organogel with a sodium alginate solution to create a low-viscosity oil-in-water emulsion. Average dry matter disappearance of gel-encapsulated holy basil was 19%, compared to 42% for the free, unprotected holy basil. However, gel encapsulation of holy basil stimulated gas production. Specifically, gas production of encapsulated holy basil was four times higher than the treatment with holy basil added on top of the gel prior to incubation rather than encapsulated within the gel. Although the gel itself was highly degradable, it is speculated encapsulation thwarted holy basil's antimicrobial activity. © 2018 Society of Chemical Industry. © 2018 Society of Chemical Industry.

  2. Novel piplartine-containing ruthenium complexes: synthesis, cell growth inhibition, apoptosis induction and ROS production on HCT116 cells.

    Science.gov (United States)

    D'Sousa Costa, Cinara O; Araujo Neto, João H; Baliza, Ingrid R S; Dias, Rosane B; Valverde, Ludmila de F; Vidal, Manuela T A; Sales, Caroline B S; Rocha, Clarissa A G; Moreira, Diogo R M; Soares, Milena B P; Batista, Alzir A; Bezerra, Daniel P

    2017-11-28

    Piplartine (piperlongumine) is a plant-derived molecule that has been receiving intense interest due to its anticancer characteristics that target the oxidative stress. In the present paper, two novel piplartine-containing ruthenium complexes [Ru(piplartine)(dppf)(bipy)](PF 6 ) 2 (1) and [Ru(piplartine)(dppb)(bipy)](PF 6 ) 2 (2) were synthesized and investigated for their cellular and molecular responses on cancer cell lines. We found that both complexes are more potent than metal-free piplartine in a panel of cancer cell lines on monolayer cultures, as well in 3D model of cancer multicellular spheroids formed from human colon carcinoma HCT116 cells. Mechanistic studies uncovered that the complexes reduced the cell growth and caused phosphatidylserine externalization, internucleosomal DNA fragmentation, caspase-3 activation and loss of the mitochondrial transmembrane potential on HCT116 cells. Moreover, the pre-treatment with Z-VAD(OMe)-FMK, a pan-caspase inhibitor, reduced the complexes-induced apoptosis, indicating cell death by apoptosis through caspase-dependent and mitochondrial intrinsic pathways. Treatment with the complexes also caused a marked increase in the production of reactive oxygen species (ROS), including hydrogen peroxide, superoxide anion and nitric oxide, and decreased reduced glutathione levels. Application of N-acetyl-cysteine, an antioxidant, reduced the ROS levels and apoptosis induced by the complexes, indicating activation of ROS-mediated apoptosis pathway. RNA transcripts of several genes, including gene related to the cell cycle, apoptosis and oxidative stress, were regulated under treatment. However, the complexes failed to induce DNA intercalation. In conclusion, the complexes are more potent than piplartine against different cancer cell lines and are able to induce caspase-dependent and mitochondrial intrinsic apoptosis on HCT116 cells by ROS-mediated pathway.

  3. Finding fossils in new ways: an artificial neural network approach to predicting the location of productive fossil localities.

    Science.gov (United States)

    Anemone, Robert; Emerson, Charles; Conroy, Glenn

    2011-01-01

    Chance and serendipity have long played a role in the location of productive fossil localities by vertebrate paleontologists and paleoanthropologists. We offer an alternative approach, informed by methods borrowed from the geographic information sciences and using recent advances in computer science, to more efficiently predict where fossil localities might be found. Our model uses an artificial neural network (ANN) that is trained to recognize the spectral characteristics of known productive localities and other land cover classes, such as forest, wetlands, and scrubland, within a study area based on the analysis of remotely sensed (RS) imagery. Using these spectral signatures, the model then classifies other pixels throughout the study area. The results of the neural network classification can be examined and further manipulated within a geographic information systems (GIS) software package. While we have developed and tested this model on fossil mammal localities in deposits of Paleocene and Eocene age in the Great Divide Basin of southwestern Wyoming, a similar analytical approach can be easily applied to fossil-bearing sedimentary deposits of any age in any part of the world. We suggest that new analytical tools and methods of the geographic sciences, including remote sensing and geographic information systems, are poised to greatly enrich paleoanthropological investigations, and that these new methods should be embraced by field workers in the search for, and geospatial analysis of, fossil primates and hominins. Copyright © 2011 Wiley-Liss, Inc.

  4. Synthesis and anticancer activity of silver(I)-N-heterocyclic carbene complexes derived from the natural xanthine products caffeine, theophylline and theobromine.

    Science.gov (United States)

    Mohamed, Heba A; Lake, Benjamin R M; Laing, Thomas; Phillips, Roger M; Willans, Charlotte E

    2015-04-28

    A new library of silver(I)-N-heterocyclic carbene complexes prepared from the natural products caffeine, theophylline and theobromine is reported. The complexes have been fully characterised using a combination of NMR spectroscopy, mass spectrometry, elemental analysis and X-ray diffraction analysis. Furthermore, the hydrophobicity of the complexes has been measured. The silver(I)-N-heterocyclic carbenes have been evaluated for their antiproliferative properties against a range of cancer cell lines of different histological types, and compared to cisplatin. The data shows different profiles of response when compared to cisplatin in the same panel of cells, indicating a different mechanism of action. Furthermore, it appears that the steric effect of the ligand and the hydrophobicity of the complex both play a role in the chemosensitivity of these compounds, with greater steric bulk and greater hydrophilicity delivering higher cytotoxicity.

  5. Vitrification of contaminated soils from the Charleston Naval Complex

    International Nuclear Information System (INIS)

    O'Connor, William K.; Turner, Paul C.; Brosnan, D.A.; Mussro, R.; Addison, G.W.; Jackson, V.B.; Teaster, G.F.

    1998-01-01

    Demonstration melting tests for vitrifying chrome- and lead-bearing wastes from the Charleston Naval Complex, and organic-contaminated dredging spoils from the Ashley River (part of the greater Charleston Harbor), were conducted in a 3-phase AC, graphite electrode arc furnace located at the Albany Research Center (ALRC) of the U.S. Department of Energy (DOE). These tests were conducted in cooperation with the Center for Engineering Ceramic Manufacturing (CECM) of Clemson University, and AJT Enterprises, Inc., of Charleston, South Carolina, and were funded by the DOE Office of Environmental Restoration. The two waste streams were composited into separate furnace feed mixtures by blending and agglomeration with readily available industrial minerals. Over 11,340 kg (25,000 lb) of feed was processed during the demonstration melting test, at feed rates up to 523 kg/h (1,150 lb/h). Continuous feeding and glass tapping was achieved for both the dredging spoils feed mixture and the naval complex mixture. Roughly 85% of all feed reported to the glass products, which readily passed the Environmental Protection Agency (EPA) Toxicity Characteristic Leaching Procedure (TCLP). ASTM aggregate tests using the vitrified aggregate in concrete and asphaltic cements indicated a potential for utilization of these materials in concentrations from 5-15% of the total aggregate, without negative impact on the mix. Toxicological tests performed on the glass products found that this material appears to be nonhazardous and its use is not likely to result in a public health risk

  6. Optimization of location routing inventory problem with transshipment

    Science.gov (United States)

    Ghani, Nor Edayu Abd; Shariff, S. Sarifah Radiah; Zahari, Siti Meriam

    2015-05-01

    Location Routing Inventory Problem (LRIP) is a collaboration of the three components in the supply chain. It is confined by location-allocation, vehicle routing and inventory management. The aim of the study is to minimize the total system cost in the supply chain. Transshipment is introduced in order to allow the products to be shipped to a customer who experiences a shortage, either directly from the supplier or from another customer. In the study, LRIP is introduced with the transshipment (LRIPT) and customers act as the transshipment points. We select the transshipment point by using the p-center and we present the results in two divisions of cases. Based on the analysis, the results indicated that LRIPT performed well compared to LRIP.

  7. An Application Of Facility Location Models With Hotspot Analysis For Optimal Location Of Abattoir Bio-Energy Plant In Anambra State Of Nigeria

    Directory of Open Access Journals (Sweden)

    E. C. Chukwuma

    2015-08-01

    Full Text Available Poor waste management strategy in abattoir in the the study area has needs a major attention considering it negative impacts on man land and water. Sitting of centralized biogas plant in a strategic location in the state would be the major means of combating the environmental challenges of increase in abattoir waste generation as result of population explosion in the state. This study investigates optimal location for sitting central abattoir waste treatment facility in Anambra State of Nigeria using facility location models with hotspot analysis in GIS environment. The result of the study shows that Using centre of gravity model the central location was estimated to be at Xc Yc 6.900953016 6.110157865. Based on inadequacy of the model hotspot analysis operation was done the hotspot analysis delineated clusters of abattoirs significantly higher in bio-wastes production than the overall study area. The hotspot analysis shows that the West regions of the study area has many abattoir that is classified as hotspot abattoirs. Using the hotspot abattoirs as proposed sites for load-distance model three abattoirs were identified as proposed sites- Obosi slaugher house Nkpor Private slaughter house and Oye-olise Ogbunike slaugher house. Their load distance values are 17250.40058 16299.24005 and 18210.14631 respectively. The optimal location for construction of central abattoir bio-waste treatment facility based on the application of these location facility models and hotspot analysis is Nkpor private slaughter house or its environs.

  8. Ethical education in software engineering: responsibility in the production of complex systems.

    Science.gov (United States)

    Génova, Gonzalo; González, M Rosario; Fraga, Anabel

    2007-12-01

    Among the various contemporary schools of moral thinking, consequence-based ethics, as opposed to rule-based, seems to have a good acceptance among professionals such as software engineers. But naïve consequentialism is intellectually too weak to serve as a practical guide in the profession. Besides, the complexity of software systems makes it very hard to know in advance the consequences that will derive from professional activities in the production of software. Therefore, following the spirit of well-known codes of ethics such as the ACM/IEEE's, we advocate for a more solid position in the ethical education of software engineers, which we call 'moderate deontologism', that takes into account both rules and consequences to assess the goodness of actions, and at the same time pays an adequate consideration to the absolute values of human dignity. In order to educate responsible professionals, however, this position should be complemented with a pedagogical approach to virtue ethics.

  9. VLC-based indoor location awareness using LED light and image sensors

    Science.gov (United States)

    Lee, Seok-Ju; Yoo, Jong-Ho; Jung, Sung-Yoon

    2012-11-01

    Recently, indoor LED lighting can be considered for constructing green infra with energy saving and additionally providing LED-IT convergence services such as visible light communication (VLC) based location awareness and navigation services. For example, in case of large complex shopping mall, location awareness to navigate the destination is very important issue. However, the conventional navigation using GPS is not working indoors. Alternative location service based on WLAN has a problem that the position accuracy is low. For example, it is difficult to estimate the height exactly. If the position error of the height is greater than the height between floors, it may cause big problem. Therefore, conventional navigation is inappropriate for indoor navigation. Alternative possible solution for indoor navigation is VLC based location awareness scheme. Because indoor LED infra will be definitely equipped for providing lighting functionality, indoor LED lighting has a possibility to provide relatively high accuracy of position estimation combined with VLC technology. In this paper, we provide a new VLC based positioning system using visible LED lights and image sensors. Our system uses location of image sensor lens and location of reception plane. By using more than two image sensor, we can determine transmitter position less than 1m position error. Through simulation, we verify the validity of the proposed VLC based new positioning system using visible LED light and image sensors.

  10. Rapid formation of complexity in the total synthesis of natural products enabled by oxabicyclo[2.2.1]heptene building blocks.

    Science.gov (United States)

    Schindler, Corinna S; Carreira, Erick M

    2009-11-01

    This critical review showcases examples of rapid formation of complexity in total syntheses starting from 7-oxabicyclo[2.2.1]hept-5-ene derivatives. An overview of methods allowing synthetic access to these building blocks is provided and their application in recently developed synthetic transformations to structurally complex systems is illustrated. In addition, the facile access to a novel oxabicyclo[2.2.1]heptene derived building block is presented which significantly enlarges the possibilities of previously known chemical transformations and is highlighted in the enantioselective route to the core of the banyaside and suomilide natural products (107 references).

  11. Complex Topographic Feature Ontology Patterns

    Science.gov (United States)

    Varanka, Dalia E.; Jerris, Thomas J.

    2015-01-01

    Semantic ontologies are examined as effective data models for the representation of complex topographic feature types. Complex feature types are viewed as integrated relations between basic features for a basic purpose. In the context of topographic science, such component assemblages are supported by resource systems and found on the local landscape. Ontologies are organized within six thematic modules of a domain ontology called Topography that includes within its sphere basic feature types, resource systems, and landscape types. Context is constructed not only as a spatial and temporal setting, but a setting also based on environmental processes. Types of spatial relations that exist between components include location, generative processes, and description. An example is offered in a complex feature type ‘mine.’ The identification and extraction of complex feature types are an area for future research.

  12. Interface between the production plan and the master production schedule in assembly environments

    OpenAIRE

    Moya Navarro, Marcos; Sánchez Brenes, Magaly

    2012-01-01

    In a production environment there is a direct relationship between the market and the manufacturing process of goods.When production is immersed in an assembly environment, the process of production planning and scheduling becomes complex, and the enterprises have the risk of losing competitive advantages in terms of not meeting delivery dates and production high costs. Linear programming has become an appropriate tool for production planning and scheduling in complex manufacturing environmen...

  13. MICROBIOLOGICAL QUALITY AND FACTORS THAT IMPACT MILK PRODUCTION FROM FAMILY FARMS LOCATED NORTH OF THE STATE OF ESPÍRITO SANTO

    Directory of Open Access Journals (Sweden)

    Maria da Penha Píccolo Ramos

    2014-07-01

    Full Text Available Milk production in São Mateus, ES, is a traditional and important socioeconomic activity for family farmers and for the state. The aim of this study was to evaluate the production characteristics of four rural communities, coded as A, B, C and D, as well as the microbiological quality of raw milk in one of these locations. The four communities were based on family farms. Community A was composed of 4 farmers; community B was composed of 12 farmers; community C was composed of 10 farmers and community D was composed of 2 farmers, totaling 28 family farms in the city of São Mateus, northern region of the State of Espírito Santo. The quality of milk samples from 10 producers of community C was assessed after milking, as well as samples from the collective cooling tank, in five repetitions. A structured questionnaire based on the requirements of the legislation of the Ministry of Agriculture, Livestock and Supply was sent to each farmer from the 28 farms. The questions included cleaning and physical structure of the barn, quality of water, hygiene practice of milkers and animals and tests for detection of mastitis. None of the farms performed pre-dipping and post-dipping. Thirty (30 samples (55.0% and 25 samples (45.5% of the total 55 samples assessed did not meet the standards for total bacterial count (TBC and somatic cell count (SCC, respectively. Nonconformities were detected in the stages of production, and milk samples did not meet microbiological standards. Milk production should be improved and Good Agricultural Practices (GAP should be implemented in the farms to ensure food safety and the sustainability of the segment in the northern region of the state of Espírito Santo.

  14. Distribution of nuclease attack sites and complexity of DNA in the products of post-irradiation degradiation of rat thymus chromatin

    International Nuclear Information System (INIS)

    Zvonareva, N.B.; Zhivotovsky, B.D.; Hanson, K.P.

    1983-01-01

    The distribution of nuclease attack sites in chromatin has been studied on the basis of the quantitative relationship of the single- and double-stranded fragments of various lengths in the products of post-irradiation degradation of chromatin (PDN). It has been shown that in irradiated thymocytes internucleosome degradation of chromatin occurs and the products of the enzymic digestion of chromatin derive from randomly distributed genome areas accumulate. Analysis of the reassociation curves has not shown any differences in the complexity of the PDN fractions and total DNA. (author)

  15. Nuclear weapons complex

    International Nuclear Information System (INIS)

    Rezendes, V.S.

    1992-04-01

    In addition to long-standing safety and environmental problems plaguing the nuclear weapons complex, this paper reports that the Department of Energy (DOE) faces a major new challenge-how to reconfigure the weapons complex to meet the nation's defense needs in the 21st century. Key decisions still need to be made about the size of the complex; where, if necessary, to relocate various operations; what technologies to use for new tritium production; and what to do with excess weapons-grade material. The choices confronting DOE and Congress are difficult given the conflicting demands for limited resources

  16. The uranium potential of the Bushveld Complex, South Africa

    International Nuclear Information System (INIS)

    Simpson, P.R.

    1986-04-01

    This paper presents a summary on much of the existing geochemical data on the siliceous components of the Bushveld Complex (i.e., the felsites, granophyres and granites) with a view to establishing the U potential of the district. Although very few U analyses are actually available, sophisticated normalised data plots are utilized to estimate the probable U contents of the rock types. The members of the siliceous suite exhibit a gradual chemical evolution through time and illustrates that the most evolved members of the suite probably contained the highest primary U contents. It is emphasized that most known Bushveld Sn and F occurrences, with which U is likely to be associated, and most of the recognized radiometric anomalies in the complex, are concentrated along major lineaments. In this respect the Murchison and Franspoort directions are considered to be particularly important. In conclusion the argument follows that the potential for undiscovered hydrothermal U ores in the Bushveld Complex is high, and that five factors will probably control the location of such deposits. These factors include: 1. Sn, F and LIL-enriched source granite; 2. High post-emplacement heat production to promote the development of post-emplacement mineralizing systems; 3. A tectonically unstable source region with major fracture zones; 4. Suitable trap environments in the granites and their country rocks; 5. A source of fluids from aquifers in the granite aureole

  17. Consistent manufacturing and quality control of a highly complex recombinant polyclonal antibody product for human therapeutic use.

    Science.gov (United States)

    Frandsen, Torben P; Naested, Henrik; Rasmussen, Søren K; Hauptig, Peter; Wiberg, Finn C; Rasmussen, Lone Kjaer; Jensen, Anne Marie Valentin; Persson, Pia; Wikén, Margareta; Engström, Anders; Jiang, Yun; Thorpe, Susan J; Förberg, Cecilia; Tolstrup, Anne B

    2011-09-01

    The beneficial effect of antibody therapy in human disease has become well established mainly for the treatment of cancer and immunological disorders. The inherent monospecificity of mAbs present limitations to mAb therapy which have become apparent notably in addressing complex entities like infectious agents or heterogenic endogenous targets. For such indications mixtures of antibodies comprising a combination of specificities would convey more potent biological effect which could translate into therapeutic efficacy. Recombinant polyclonal antibodies (rpAb) consisting of a defined number of well-characterized mAbs constitute a new class of target specific antibody therapy. We have developed a cost-efficient cell banking and single-batch manufacturing concept for the production of such products and demonstrate that a complex pAb composition, rozrolimupab, comprising 25 individual antibodies can be manufactured in a highly consistent manner in a scaled-up manufacturing process. We present a strategy for the release and characterization of antibody mixtures which constitute a complete series of chemistry, manufacturing, and control (CMC) analytical methods to address identity, purity, quantity, potency, and general characteristics. Finally we document selected quality attributes of rozrolimupab based on a battery of assays at the genetic-, protein-, and functional level and demonstrate that the manufactured rozrolimupab batches are highly pure and very uniform in their composition. Copyright © 2011 Wiley Periodicals, Inc.

  18. 'In-Crystallo' Capture of a Michaelis Complex And Product Binding Modes of a Bacterial Phosphotriesterase

    Energy Technology Data Exchange (ETDEWEB)

    Jackson, C.J.; Foo, J.-L.; Kim, H.-K.; Carr, P.D.; Liu, J.-W.; Salem, G.; Ollis, D.L.

    2009-05-18

    The mechanism by which the binuclear metallophosphotriesterases (PTEs, E.C. 3.1.8.1) catalyse substrate hydrolysis has been extensively studied. The {mu}-hydroxo bridge between the metal ions has been proposed to be the initiating nucleophile in the hydrolytic reaction. In contrast, analysis of some biomimetic systems has indicated that {mu}-hydroxo bridges are often not themselves nucleophiles, but act as general bases for freely exchangeable nucleophilic water molecules. Herein, we present crystallographic analyses of a bacterial PTE from Agrobacterium radiobacter, OpdA, capturing the enzyme-substrate complex during hydrolysis. This model of the Michaelis complex suggests the alignment of the substrate will favor attack from a solvent molecule terminally coordinated to the {alpha}-metal ion. The bridging of both metal ions by the product, without disruption of the {mu}-hydroxo bridge, is also consistent with nucleophilic attack occurring from the terminal position. When phosphodiesters are soaked into crystals of OpdA, they coordinate bidentately to the {beta}-metal ion, displacing the {mu}-hydroxo bridge. Thus, alternative product-binding modes exist for the PTEs, and it is the bridging mode that appears to result from phosphotriester hydrolysis. Kinetic analysis of the PTE and promiscuous phosphodiesterase activities confirms that the presence of a {mu}-hydroxo bridge during phosphotriester hydrolysis is correlated with a lower pK{sub a} for the nucleophile, consistent with a general base function during catalysis.

  19. Potential bioethanol feedstock availability around nine locations in the Republic of Ireland

    Energy Technology Data Exchange (ETDEWEB)

    Deverell, R.; McDonnell, K.; Devlin, G. [Department of Biosystems Engineering, Agriculture and Food Science Building, University College Dublin, Belfield (Ireland)

    2009-07-01

    The Republic of Ireland, like many other countries is trying to diversify energy sources to counteract environmental, political and social concerns. Bioethanol from domestically grown agricultural crops is an indigenously produced alternative fuel that can potentially go towards meeting the goal of diversified energy supply. The Republic of Ireland's distribution of existing soils and agricultural land-uses limit arable crop land to around 10% of total agricultural area. Demand for land to produce arable crops is expected to decrease, which could open the opportunity for bioethanol production. Bioethanol production plants are required to be of a sufficient scale in order to compete economically with other fuel sources, it is important therefore to determine if enough land exists around potential ethanol plant locations to meet the potential demands for feedstock. This study determines, through the use of a developed GIS based model, the potential quantities of feedstock that is available in the hinterlands of nine locations in the Republic of Ireland. The results indicate that three locations can meet all its feedstock demands using indigenously grown sugarbeet, while only one location can meet its demands using a combination of indigenous wheat and straw as the two locally sourced feedstocks. (author)

  20. Potential Bioethanol Feedstock Availability Around Nine Locations in the Republic of Ireland

    Directory of Open Access Journals (Sweden)

    Rory Deverell

    2009-03-01

    Full Text Available The Republic of Ireland, like many other countries is trying to diversify energy sources to counteract environmental, political and social concerns. Bioethanol from domestically grown agricultural crops is an indigenously produced alternative fuel that can potentially go towards meeting the goal of diversified energy supply. The Republic of Ireland’s distribution of existing soils and agricultural land-uses limit arable crop land to around 10% of total agricultural area. Demand for land to produce arable crops is expected to decrease, which could open the opportunity for bioethanol production. Bioethanol production plants are required to be of a sufficient scale in order to compete economically with other fuel sources, it is important therefore to determine if enough land exists around potential ethanol plant locations to meet the potential demands for feedstock. This study determines, through the use of a developed GIS based model, the potential quantities of feedstock that is available in the hinterlands of nine locations in the Republic of Ireland. The results indicate that three locations can meet all its feedstock demands using indigenously grown sugarbeet, while only one location can meet its demands using a combination of indigenous wheat and straw as the two locally sourced feedstocks.

  1. Pancreatic mitochondrial complex I exhibits aberrant hyperactivity in diabetes

    Directory of Open Access Journals (Sweden)

    Jinzi Wu

    2017-09-01

    Full Text Available It is well established that NADH/NAD+ redox balance is heavily perturbed in diabetes, and the NADH/NAD+ redox imbalance is a major source of oxidative stress in diabetic tissues. In mitochondria, complex I is the only site for NADH oxidation and NAD+ regeneration and is also a major site for production of mitochondrial reactive oxygen species (ROS. Yet how complex I responds to the NADH/NAD+ redox imbalance and any potential consequences of such response in diabetic pancreas have not been investigated. We report here that pancreatic mitochondrial complex I showed aberrant hyperactivity in either type 1 or type 2 diabetes. Further studies focusing on streptozotocin (STZ-induced diabetes indicate that complex I hyperactivity could be attenuated by metformin. Moreover, complex I hyperactivity was accompanied by increased activities of complexes II to IV, but not complex V, suggesting that overflow of NADH via complex I in diabetes could be diverted to ROS production. Indeed in diabetic pancreas, ROS production and oxidative stress increased and mitochondrial ATP production decreased, which can be attributed to impaired pancreatic mitochondrial membrane potential that is responsible for increased cell death. Additionally, cellular defense systems such as glucose 6-phosphate dehydrogenase, sirtuin 3, and NQO1 were found to be compromised in diabetic pancreas. Our findings point to the direction that complex I aberrant hyperactivity in pancreas could be a major source of oxidative stress and β cell failure in diabetes. Therefore, inhibiting pancreatic complex I hyperactivity and attenuating its ROS production by various means in diabetes might serve as a promising approach for anti-diabetic therapies.

  2. How significant is perceived environmental risk to business location decisions?

    International Nuclear Information System (INIS)

    Allison, T.; Calzonetti, F.

    1996-01-01

    It has been argued that adverse perceptions of risk associated with high-level nuclear waste (HLNW) facilities will have significant impacts on the attraction of new, and the maintenance of existing business activities in areas in which adverse perceptions develop. We examine this proposition by the considering the importance of environmental amenities and a range of other factors to business location decisions using evidence from surveys of more than 400 manufacturing and business service establishments in Colorado and Utah. We show that the importance of environmental amenities varies according to a number of factors, in particular the type of product (manufactured product or business service), type of establishment (single-establishment firm or establishment of a multilocational firm) and establishment employment size. Policies designed to offset the loss of business activity that might result from adverse risk perceptions associated with HLNW facilities must therefore take into account how sensitive various forms of business activity present or likely to locate in any particular area might be to environmental factors

  3. How significant is perceived environmental risk to business location decisions?

    Energy Technology Data Exchange (ETDEWEB)

    Allison, T. [Argonne National Lab., IL (United States); Calzonetti, F. [West Virginia Univ., Morgantown, WV (United States)

    1996-12-31

    It has been argued that adverse perceptions of risk associated with high-level nuclear waste (HLNW) facilities will have significant impacts on the attraction of new, and the maintenance of existing business activities in areas in which adverse perceptions develop. We examine this proposition by the considering the importance of environmental amenities and a range of other factors to business location decisions using evidence from surveys of more than 400 manufacturing and business service establishments in Colorado and Utah. We show that the importance of environmental amenities varies according to a number of factors, in particular the type of product (manufactured product or business service), type of establishment (single-establishment firm or establishment of a multilocational firm) and establishment employment size. Policies designed to offset the loss of business activity that might result from adverse risk perceptions associated with HLNW facilities must therefore take into account how sensitive various forms of business activity present or likely to locate in any particular area might be to environmental factors.

  4. Charged Higgs Boson production at e{sup +}e{sup -} colliders in the complex MSSM: a full one-loop analysis

    Energy Technology Data Exchange (ETDEWEB)

    Heinemeyer, S. [Campus of International Excellence UAM+CSIC, Madrid (Spain); Universidad Autonoma de Madrid, Instituto de Fisica Teorica (UAM/CSIC), Madrid (Spain); Instituto de Fisica de Cantabria (CSIC-UC), Santander (Spain); Schappacher, C. [Karlsruhe Institute of Technology, Institut fuer Theoretische Physik, Karlsruhe (Germany)

    2016-10-15

    For the search for additional Higgs bosons in the Minimal Supersymmetric Standard Model (MSSM) as well as for future precision analyses in the Higgs sector precise knowledge of their production properties is mandatory. We evaluate the cross sections for the charged Higgs boson production at e{sup +}e{sup -} colliders in the MSSM with complex parameters (cMSSM). The evaluation is based on a full one-loop calculation of the production mechanism e{sup +}e{sup -} → H{sup +}H{sup -} and e{sup +}e{sup -} → H{sup ±}W{sup -+}, including soft and hard QED radiation. The dependence of the Higgs boson production cross sections on the relevant cMSSM parameters is analyzed numerically. We find sizable contributions to many cross sections. They are, depending on the production channel, roughly of 5-10 % of the tree-level results, but can go up to 20 % or higher. The full one-loop contributions are important for a future linear e{sup +}e{sup -} collider such as the ILC or CLIC. (orig.)

  5. LocateP: Genome-scale subcellular-location predictor for bacterial proteins

    Directory of Open Access Journals (Sweden)

    Zhou Miaomiao

    2008-03-01

    Full Text Available Abstract Background In the past decades, various protein subcellular-location (SCL predictors have been developed. Most of these predictors, like TMHMM 2.0, SignalP 3.0, PrediSi and Phobius, aim at the identification of one or a few SCLs, whereas others such as CELLO and Psortb.v.2.0 aim at a broader classification. Although these tools and pipelines can achieve a high precision in the accurate prediction of signal peptides and transmembrane helices, they have a much lower accuracy when other sequence characteristics are concerned. For instance, it proved notoriously difficult to identify the fate of proteins carrying a putative type I signal peptidase (SPIase cleavage site, as many of those proteins are retained in the cell membrane as N-terminally anchored membrane proteins. Moreover, most of the SCL classifiers are based on the classification of the Swiss-Prot database and consequently inherited the inconsistency of that SCL classification. As accurate and detailed SCL prediction on a genome scale is highly desired by experimental researchers, we decided to construct a new SCL prediction pipeline: LocateP. Results LocateP combines many of the existing high-precision SCL identifiers with our own newly developed identifiers for specific SCLs. The LocateP pipeline was designed such that it mimics protein targeting and secretion processes. It distinguishes 7 different SCLs within Gram-positive bacteria: intracellular, multi-transmembrane, N-terminally membrane anchored, C-terminally membrane anchored, lipid-anchored, LPxTG-type cell-wall anchored, and secreted/released proteins. Moreover, it distinguishes pathways for Sec- or Tat-dependent secretion and alternative secretion of bacteriocin-like proteins. The pipeline was tested on data sets extracted from literature, including experimental proteomics studies. The tests showed that LocateP performs as well as, or even slightly better than other SCL predictors for some locations and outperforms

  6. Light-Harvesting Complex Protein LHCBM9 Is Critical for Photosystem II Activity and Hydrogen Production in Chlamydomonas reinhardtii[C][W

    Science.gov (United States)

    Grewe, Sabrina; Ballottari, Matteo; Alcocer, Marcelo; D’Andrea, Cosimo; Blifernez-Klassen, Olga; Hankamer, Ben; Mussgnug, Jan H.; Bassi, Roberto; Kruse, Olaf

    2014-01-01

    Photosynthetic organisms developed multiple strategies for balancing light-harvesting versus intracellular energy utilization to survive ever-changing environmental conditions. The light-harvesting complex (LHC) protein family is of paramount importance for this function and can form light-harvesting pigment protein complexes. In this work, we describe detailed analyses of the photosystem II (PSII) LHC protein LHCBM9 of the microalga Chlamydomonas reinhardtii in terms of expression kinetics, localization, and function. In contrast to most LHC members described before, LHCBM9 expression was determined to be very low during standard cell cultivation but strongly increased as a response to specific stress conditions, e.g., when nutrient availability was limited. LHCBM9 was localized as part of PSII supercomplexes but was not found in association with photosystem I complexes. Knockdown cell lines with 50 to 70% reduced amounts of LHCBM9 showed reduced photosynthetic activity upon illumination and severe perturbation of hydrogen production activity. Functional analysis, performed on isolated PSII supercomplexes and recombinant LHCBM9 proteins, demonstrated that presence of LHCBM9 resulted in faster chlorophyll fluorescence decay and reduced production of singlet oxygen, indicating upgraded photoprotection. We conclude that LHCBM9 has a special role within the family of LHCII proteins and serves an important protective function during stress conditions by promoting efficient light energy dissipation and stabilizing PSII supercomplexes. PMID:24706511

  7. Elevated levels of mitochonrial respiratory complexes activities and ATP production in 17-β-estradiol-induced prolactin-secretory tumor cells in male rats are inhibited by melatonin in vivo and in vitro.

    Science.gov (United States)

    Wang, Bao-Qiang; Yang, Quan-Hui; Xu, Rong-Kun; Xu, Jian-Ning

    2013-01-01

    Our earlier studies indicate that melatonin inhibits the proliferation of prolactinoma and induces apoptosis of pituitary prolactin-secreting tumor in rats. Melatonin has also been shown to induce apoptosis and to reduce the production of ATP in breast tumor cells. This study analyzed the levels of the four mitochondrial respiratory complexes and the production of ATP and also the effects of melatonin treatment of prolactinoma. In the in vivo study, mitochondria were harvested from control pituitaries or prolactinoma collected from the pituitaries of melatonin- and 17-β-estradiol (E2)-treated male rats. In the in vitro study, prolactinoma cells mitochondria were harvested. Activities of the four mitochondrial respiratory complexes were assayed using fluorometer. ATP production of prolactinoma cells was estimated using bioluminescent methods. Elevated levels of four mitochondrial respiratory complexes activities and ATP production were recorded in prolactinoma cells. Moreover, in both in vivo and in vitro studies, melatonin inhibited the activities of mitochondrial respiratory complexes and the production of ATP in prolactinoma cells. There is a link between mitochondrial function increase and tumorigenesis. Melatonin induces apoptosis of pituitary prolactin-secreting tumor of rats via the induction of mitochondrial dysfunction and inhibition of energy metabolism.

  8. Improving the Complexity of the Lorenz Dynamics

    Directory of Open Access Journals (Sweden)

    María Pilar Mareca

    2017-01-01

    Full Text Available A new four-dimensional, hyperchaotic dynamic system, based on Lorenz dynamics, is presented. Besides, the most representative dynamics which may be found in this new system are located in the phase space and are analyzed here. The new system is especially designed to improve the complexity of Lorenz dynamics, which, despite being a paradigm to understand the chaotic dissipative flows, is a very simple example and shows great vulnerability when used in secure communications. Here, we demonstrate the vulnerability of the Lorenz system in a general way. The proposed 4D system increases the complexity of the Lorenz dynamics. The trajectories of the novel system include structures going from chaos to hyperchaos and chaotic-transient solutions. The symmetry and the stability of the proposed system are also studied. First return maps, Poincaré sections, and bifurcation diagrams allow characterizing the global system behavior and locating some coexisting structures. Numerical results about the first return maps, Poincaré cross sections, Lyapunov spectrum, and Kaplan-Yorke dimension demonstrate the complexity of the proposed equations.

  9. Chargino and neutralino production at e{sup +}e{sup -} colliders in the complex MSSM. A full one-loop analysis

    Energy Technology Data Exchange (ETDEWEB)

    Heinemeyer, S. [Campus of International Excellence UAM+CSIC, Madrid (Spain); Universidad Autonoma de Madrid, Cantoblanco, Instituto de Fisica Teorica (UAM/CSIC), Madrid (Spain); Instituto de Fisica de Cantabria (CSIC-UC), Santander (Spain); Schappacher, C.

    2017-09-15

    For the search for charginos and neutralinos in the Minimal Supersymmetric Standard Model (MSSM) as well as for future precision analyses of these particles an accurate knowledge of their production and decay properties is mandatory. We evaluate the cross sections for the chargino and neutralino production at e{sup +}e{sup -} colliders in the MSSM with complex parameters (cMSSM). The evaluation is based on a full one-loop calculation of the production mechanisms e{sup +}e{sup -} → χ{sub c}{sup ±}χ{sub c}{sup {sub '}-+} and e{sup +}e{sup -} → χ{sub n}{sup 0}χ{sub n}{sup {sub '}0} including soft and hard photon radiation. We mostly restricted ourselves to a version of our renormalization scheme which is valid for vertical stroke M{sub 1} vertical stroke < vertical stroke M{sub 2} vertical stroke, vertical stroke μ vertical stroke and M{sub 2} ≠ μ to simplify the analysis, even though we are able to switch to other parameter regions and correspondingly different renormalization schemes. The dependence of the chargino/neutralino cross sections on the relevant cMSSM parameters is analyzed numerically. We find sizable contributions to many production cross sections. They amount to roughly ±15% of the tree-level results but can go up to ±40% or higher in extreme cases. Also the complex phase dependence of the one-loop corrections was found non-negligible. The full one-loop contributions are thus crucial for physics analyses at a future linear e{sup +}e{sup -} collider such as the ILC or CLIC. (orig.)

  10. Production and sympathetic cooling of complex molecular ions

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Chaobo

    2008-06-24

    This thesis reports on experimental and theoretical studies of the sympathetic cooling of complex molecular ions demonstrating that this general method for cooling atomic and molecular ions is reliable and efficient. For this purpose, complex molecular ions and barium ions have been confined simultaneously in a linear Paul trap. The complex molecular ions are generated in an electrospray ionization system and transferred to the trap via a 2 m long octopole ion guide. These molecular ions are pre-cooled by room temperature helium buffer gas so that they can be captured by the trap. The atomic barium ions are loaded from a barium evaporator oven and are laser-cooled by a 493 nm cooling laser and a 650 nm repumping laser. Due to the mutual Coulomb interaction among these charged particles, the kinetic energy of the complex molecular ions can be reduced significantly. In our experiments we have demonstrated the sympathetic cooling of various molecules (CO{sub 2}, Alexa Fluor 350, glycyrrhetinic acid, cytochrome c) covering a wide mass range from a few tens to 13000 amu. In every case the molecular ions could be cooled down to millikelvin temperatures. Photo-chemical reactions of the {sup 138}Ba{sup +} ions in the ({sup 2}P{sub 1/2}) excited state with gases such as O{sub 2}, CO{sub 2}, or N{sub 2}O, could be observed. If the initial {sup 138}Ba{sup +} ion ensemble is cold, the produced {sup 138}BaO{sup +} ions are cold as well, with a similar temperature as the laser-cooled barium ions (a few tens of millikelvin). The back-reaction of {sup 138}BaO{sup +} ions with neutral CO to {sup 138}Ba{sup +} is possible and was observed in our experiments as well. A powerful molecular dynamics (MD) simulation program has been developed. With this program dynamic properties of ion ensembles, such as sympathetic interactions or heating effects, have been investigated and experimental results have been analyzed to obtain, for example, ion numbers and temperatures. Additionally, the

  11. Production and sympathetic cooling of complex molecular ions

    International Nuclear Information System (INIS)

    Zhang, Chaobo

    2008-01-01

    This thesis reports on experimental and theoretical studies of the sympathetic cooling of complex molecular ions demonstrating that this general method for cooling atomic and molecular ions is reliable and efficient. For this purpose, complex molecular ions and barium ions have been confined simultaneously in a linear Paul trap. The complex molecular ions are generated in an electrospray ionization system and transferred to the trap via a 2 m long octopole ion guide. These molecular ions are pre-cooled by room temperature helium buffer gas so that they can be captured by the trap. The atomic barium ions are loaded from a barium evaporator oven and are laser-cooled by a 493 nm cooling laser and a 650 nm repumping laser. Due to the mutual Coulomb interaction among these charged particles, the kinetic energy of the complex molecular ions can be reduced significantly. In our experiments we have demonstrated the sympathetic cooling of various molecules (CO 2 , Alexa Fluor 350, glycyrrhetinic acid, cytochrome c) covering a wide mass range from a few tens to 13000 amu. In every case the molecular ions could be cooled down to millikelvin temperatures. Photo-chemical reactions of the 138 Ba + ions in the ( 2 P 1/2 ) excited state with gases such as O 2 , CO 2 , or N 2 O, could be observed. If the initial 138 Ba + ion ensemble is cold, the produced 138 BaO + ions are cold as well, with a similar temperature as the laser-cooled barium ions (a few tens of millikelvin). The back-reaction of 138 BaO + ions with neutral CO to 138 Ba + is possible and was observed in our experiments as well. A powerful molecular dynamics (MD) simulation program has been developed. With this program dynamic properties of ion ensembles, such as sympathetic interactions or heating effects, have been investigated and experimental results have been analyzed to obtain, for example, ion numbers and temperatures. Additionally, the feasibility of nondestructive spectroscopy via an optical dipole excitation

  12. "Good is up" is not always better: a memory advantage for words in metaphor-incompatible locations.

    Directory of Open Access Journals (Sweden)

    L Elizabeth Crawford

    Full Text Available Four experiments examined whether memory for positive and negative words depended on word location and vertical hand movements. Cognitive processing is known to be facilitated when valenced stimuli are presented in locations that are congruent with the GOOD is UP conceptual metaphor, relative to when they are presented in incongruent locations. In both free recall and recognition tasks, we find a memory advantage for words that had been studied in metaphor incongruent locations (positive down, negative up. This incongruity advantage depends on the location of words during encoding, but no evidence was found to suggest that other spatial associations, such as the vertical position of the hand at encoding or word location during retrieval, affect memory. The results indicate that metaphors, like schemas, categories, and stereotypes, can influence cognition in complex ways, producing variable outcomes across different tasks.

  13. "Good is up" is not always better: a memory advantage for words in metaphor-incompatible locations.

    Science.gov (United States)

    Crawford, L Elizabeth; Cohn, Stephanie M; Kim, Arnold B

    2014-01-01

    Four experiments examined whether memory for positive and negative words depended on word location and vertical hand movements. Cognitive processing is known to be facilitated when valenced stimuli are presented in locations that are congruent with the GOOD is UP conceptual metaphor, relative to when they are presented in incongruent locations. In both free recall and recognition tasks, we find a memory advantage for words that had been studied in metaphor incongruent locations (positive down, negative up). This incongruity advantage depends on the location of words during encoding, but no evidence was found to suggest that other spatial associations, such as the vertical position of the hand at encoding or word location during retrieval, affect memory. The results indicate that metaphors, like schemas, categories, and stereotypes, can influence cognition in complex ways, producing variable outcomes across different tasks.

  14. Servitization, Services and Managing Complexity

    DEFF Research Database (Denmark)

    Harjo, Ieva; Frandsen, Thomas; Hsuan, Juliana

    This paper explores how seemingly complex servitized solutions can become tradable in a customer–supplier relationship by objectification and abbreviation. The key argument is that the complexity of product-service solutions can be reduced by abbreviation of the reality in written form of contracts...

  15. Antiproton complex at the FAIR project

    International Nuclear Information System (INIS)

    Dolinskii, A.; Knie, K.; Dimopoulou, C.; Gostishchev, V.; Litvinov, S.; Nolden, F.; Steck, M.

    2011-01-01

    This report summarizes a set of calculations for the antiproton production in a complex composed of target area, collector, separator, beam line and collector ring for the antiproton source of the future FAIR facility (Facility for Antiproton and Ion Research) at GSI, Darmstadt, Germany. The emphasis is on the optimization of the accumulation rate of antiprotons in order to maximize the luminosity of experiments with cooled antiproton beams in the High Energy Storage Ring (HESR). Results of simulations for each component of the antiproton production complex are presented in order to identify the present limitations of the antiproton production rate.

  16. Coupling a Neural Network with Atmospheric Flow Simulations to Locate and Quantify CH4 Emissions at Well Pads

    Science.gov (United States)

    Travis, B. J.; Sauer, J.; Dubey, M. K.

    2017-12-01

    Methane (CH4) leaks from oil and gas production fields are a potentially significant source of atmospheric methane. US DOE's ARPA-E office is supporting research to locate methane emissions at 10 m size well pads to within 1 m. A team led by Aeris Technologies, and that includes LANL, Planetary Science Institute and Rice University has developed an autonomous leak detection system (LDS) employing a compact laser absorption methane sensor, a sonic anemometer and multiport sampling. The LDS system analyzes monitoring data using a convolutional neural network (cNN) to locate and quantify CH4 emissions. The cNN was trained using three sources: (1) ultra-high-resolution simulations of methane transport provided by LANL's coupled atmospheric transport model HIGRAD, for numerous controlled methane release scenarios and methane sampling configurations under variable atmospheric conditions, (2) Field tests at the METEC site in Ft. Collins, CO., and (3) Field data from other sites where point-source surface methane releases were monitored downwind. A cNN learning algorithm is well suited to problems in which the training and observed data are noisy, or correspond to complex sensor data as is typical of meteorological and sensor data over a well pad. Recent studies with our cNN emphasize the importance of tracking wind speeds and directions at fine resolution ( 1 second), and accounting for variations in background CH4 levels. A few cases illustrate the importance of sufficiently long monitoring; short monitoring may not provide enough information to determine accurately a leak location or strength, mainly because of short-term unfavorable wind directions and choice of sampling configuration. Length of multiport duty cycle sampling and sample line flush time as well as number and placement of monitoring sensors can significantly impact ability to locate and quantify leaks. Source location error at less than 10% requires about 30 or more training cases.

  17. Public Transportation and Industrial Location Patterns in California

    OpenAIRE

    Chatman , Daniel; Xu, Ruoying; Park , Janice; Le, Kim

    2016-01-01

    Public transit investments are a large and growing share of all transportation investments in the state of California, and such critical investments should be evaluated partly on their economic benefits. Taking such benefits into account could alter investment, service, and service restructuring decisions taken by transit agencies in the state. The relationship of public transportation to economic productivity, and spatial patterns of industrial location, is understudied. This project investi...

  18. Economic interpretation of sustainable development of the flax complex

    Directory of Open Access Journals (Sweden)

    Oleg Ivanovich Botkin

    2012-09-01

    Full Text Available This paper reviews the definition of the notions “stability” and “stable development”, and analyzes the factors influencing the development stability. We suggest the definition of the flax complex stable development and its assessment. We also examine the factors causing the flax complex functioning instability. An integral index was proposed to determine the stability of flax complex; this index takes into account the rate of growth (or decline of major products manufacturing, commodities, profits from product sales, accounts receivable and accounts payable, investments into fixed capital, labor productivity, coefficient of manufacturing capacity utilization and updating of the basic funds. The paper deals with the problems of its development and modern state of flax sub-complex of agroindustrial complex, as well as with the matters of disproportions between the complex’s branches. It covers the causes of tolling schemes of flax processing businesses work and therole of thestatein native market of flax products formation. The necessity of industry diversification and innovation development is substantiated.

  19. Generalized location-based resource allocation for OFDMA cognitive radio systems

    KAUST Repository

    Ben Ghorbel, Mahdi

    2010-09-01

    Cognitive radio is one of the hot topics for emerging and future wireless communication. Cognitive users can share channels with primary users under the condition of non interference. In order to compute this interference, the cognitive system usually use the channel state information of the primary user which is often impractical to obtain. However, using location information, we can estimate this interference by pathloss computation. In this paper, we introduce a low-complexity resource allocation algorithm for orthogonal frequency division multiple access (OFDMA) based cognitive radio systems, which uses relative location information between primary and secondary users to estimate the interference. This algorithm considers interference with multiple primary users having different thresholds. The simulation results show the efficiency of the proposed algorithm by comparing it with an optimal exhaustive search method. © 2010 IEEE.

  20. Producing complex spoken numerals for time and space

    NARCIS (Netherlands)

    Meeuwissen, M.H.W.

    2004-01-01

    This thesis addressed the spoken production of complex numerals for time and space. The production of complex numerical expressions like those involved in telling time (e.g., 'quarter to four') or producing house numbers (e.g., 'two hundred forty-five') has been almost completely ignored. Yet, adult

  1. Sex differences in the weighting of metric and categorical information in spatial location memory.

    Science.gov (United States)

    Holden, Mark P; Duff-Canning, Sarah J; Hampson, Elizabeth

    2015-01-01

    According to the Category Adjustment model, remembering a spatial location involves the Bayesian combination of fine-grained and categorical information about that location, with each cue weighted by its relative certainty. However, individuals may differ in terms of their certainty about each cue, resulting in estimates that rely more or less on metric or categorical representations. To date, though, very little research has examined individual differences in the relative weighting of these cues in spatial location memory. Here, we address this gap in the literature. Participants were asked to recall point locations in uniform geometric shapes and in photographs of complex, natural scenes. Error patterns were analyzed for evidence of a sex difference in the relative use of metric and categorical information. As predicted, women placed relatively more emphasis on categorical cues, while men relied more heavily on metric information. Location reproduction tasks showed a similar effect, implying that the sex difference arises early in spatial processing, possibly during encoding.

  2. The impact of product complexity on ramp-up performance

    NARCIS (Netherlands)

    Pufall, A.A.; Fransoo, J.C.; Jong, de A.; Kok, de A.G.

    2012-01-01

    Fast product ramp-ups are crucial in consumer electronics because short product lifecycles prevail and profit margins diminish rapidly over time. Yet many companies fail to meet their volume, cost and quality targets and the ramp-up phase remains largely unexplored in new product and supply chain

  3. Quasi-dimensional modeling of a fast-burn combustion dual-plug spark-ignition engine with complex combustion chamber geometries

    International Nuclear Information System (INIS)

    Altın, İsmail; Bilgin, Atilla

    2015-01-01

    This study builds on a previous parametric investigation using a thermodynamic-based quasi-dimensional (QD) cycle simulation of a spark-ignition (SI) engine with dual-spark plugs. The previous work examined the effects of plug-number and location on some performance parameters considering an engine with a simple cylindrical disc-shaped combustion chamber. In order to provide QD thermodynamic models applicable to complex combustion chamber geometries, a novel approach is considered here: flame-maps, which utilizes a computer aided design (CAD) software (SolidWorks). Flame maps are produced by the CAD software, which comprise all the possible flame radiuses with an increment of one-mm between them, according to the spark plug positions, spark timing, and piston position near the top dead center. The data are tabulated and stored as matrices. Then, these tabulated data are adapted to the previously reported cycle simulation. After testing for simple disc-shaped chamber geometries, the simulation is applied to a real production automobile (Honda-Fit) engine to perform the parametric study. - Highlights: • QD model was applied in dual plug engine with complex realistic combustion chamber. • This method successfully modeled the combustion in the dual-plug Honda-Fit engine. • The same combustion chamber is tested for various spark plug(s) locations. • The centrally located single spark-plug results in the fastest combustion

  4. Planning the location of facilities to implement a reverse logistic system of post-consumer packaging using a location mathematical model.

    Science.gov (United States)

    Couto, Maria Claudia Lima; Lange, Liséte Celina; Rosa, Rodrigo de Alvarenga; Couto, Paula Rogeria Lima

    2017-12-01

    The implementation of reverse logistics systems (RLS) for post-consumer products provides environmental and economic benefits, since it increases recycling potential. However, RLS implantation and consolidation still face problems. The main shortcomings are the high costs and the low expectation of broad implementation worldwide. This paper presents two mathematical models to decide the number and the location of screening centers (SCs) and valorization centers (VCs) to implement reverse logistics of post-consumer packages, defining the optimum territorial arrangements (OTAs), allowing the inclusion of small and medium size municipalities. The paper aims to fill a gap in the literature on RLS location facilities that not only aim at revenue optimization, but also the participation of the population, the involvement of pickers and the service universalization. The results showed that implementation of VCs can lead to revenue/cost ratio higher than 100%. The results of this study can supply companies and government agencies with a global view on the parameters that influence RLS sustainability and help them make decisions about the location of these facilities and the best reverse flows with the social inclusion of pickers and serving the population of small and medium-sized municipalities.

  5. Comparing the production of complex sentences in Persian patients with post-stroke aphasia and non-damaged people with normal speaking.

    Science.gov (United States)

    Mehri, Azar; Ghorbani, Askar; Darzi, Ali; Jalaie, Shohreh; Ashayeri, Hassan

    2016-01-05

    Cerebrovascular disease leading to stroke is the most common cause of aphasia. Speakers with agrammatic non-fluent aphasia have difficulties in production of movement-derived sentences such as passive sentences, topicalized constituents, and Wh-questions. To assess the production of complex sentences, some passive, topicalized and focused sentences were designed for patients with non-fluent Persian aphasic. Afterwards, patients' performance in sentence production was tested and compared with healthy non-damaged subjects. In this cross sectional study, a task was designed to assess the different types of sentences (active, passive, topicalized and focused) adapted to Persian structures. Seven Persian patients with post-stroke non-fluent agrammatic aphasia (5 men and 2 women) and seven healthy non-damaged subjects participated in this study. The computed tomography (CT) scan or magnetic resonance imaging (MRI) showed that all the patients had a single left hemisphere lesion involved middle cerebral artery (MCA), Broca`s area and in its white matter. In addition, based on Bedside version of Persian Western Aphasia Battery (P-WAB-1), all of them were diagnosed with moderate Broca aphasia. Then, the production task of Persian complex sentences was administered. There was a significant difference between four types of sentences in patients with aphasia [Degree of freedom (df) = 3, P Persian are very difficult to produce for patients with agrammatic non-fluent aphasia. It seems that sentences with A-movement are simpler for the patients than sentences involving A`-movement; since they include shorter movements in compare to topicalized and focused sentences.

  6. Mechanistic Insights into Validoxylamine A 7'-Phosphate Synthesis by VldE Using the Structure of the Entire Product Complex

    Energy Technology Data Exchange (ETDEWEB)

    Cavalier, Michael C.; Yim, Young-Sun; Asamizu, Shumpei; Neau, David; Almabruk, Khaled H.; Mahmud, Taifo; Lee, Yong-Hwan [Oregon State U.; (Cornell); (LSU)

    2013-09-09

    The pseudo-glycosyltransferase VldE catalyzes non-glycosidic C-N coupling between an unsaturated cyclitol and a saturated aminocyclitol with the conservation of the stereochemical configuration of the substrates to form validoxylamine A 7'-phosphate, the biosynthetic precursor of the antibiotic validamycin A. To study the molecular basis of its mechanism, the three-dimensional structures of VldE from Streptomyces hygroscopicus subsp. limoneus was determined in apo form, in complex with GDP, in complex with GDP and validoxylamine A 7'-phosphate, and in complex with GDP and trehalose. The structure of VldE with the catalytic site in both an “open” and “closed” conformation is also described. With these structures, the preferred binding of the guanine moiety by VldE, rather than the uracil moiety as seen in OtsA could be explained. The elucidation of the VldE structure in complex with the entirety of its products provides insight into the internal return mechanism by which catalysis occurs with a net retention of the stereochemical configuration of the donated cyclitol.

  7. Location-based prospective memory.

    Science.gov (United States)

    O'Rear, Andrea E; Radvansky, Gabriel A

    2018-02-01

    This study explores location-based prospective memory. People often have to remember to do things when in a particular location, such as buying tissues the next time they are in the supermarket. For event cognition theory, location is important for structuring events. However, because event cognition has not been used to examine prospective memory, the question remains of how multiple events will influence prospective memory performance. In our experiments, people delivered messages from store to store in a virtual shopping mall as an ongoing task. The prospective tasks were to do certain activities in certain stores. For Experiment 1, each trial involved one prospective memory task to be done in a single location at one of three delays. The virtual environment and location cues were effective for prospective memory, and performance was unaffected by delay. For Experiment 2, each trial involved two prospective memory tasks, given in either one or two instruction locations, and to be done in either one or two store locations. There was improved performance when people received instructions from two locations and did both tasks in one location relative to other combinations. This demonstrates that location-based event structure influences how well people perform on prospective memory tasks.

  8. Accuracy Improvement of Real-Time Location Tracking for Construction Workers

    Directory of Open Access Journals (Sweden)

    Hyunsoo Kim

    2018-05-01

    Full Text Available Extensive research has been conducted on the real-time locating system (RTLS for tracking construction components, including workers, equipment, and materials, in order to improve construction performance (e.g., productivity improvement or accident prevention. In order to prevent safety accidents and make more sustainable construction job sites, the higher accuracy of RTLS is required. To improve the accuracy of RTLS in construction projects, this paper presents a RTLS using radio frequency identification (RFID. For this goal, this paper develops a location tracking error mitigation algorithm and presents the concept of using assistant tags. The applicability and effectiveness of the developed RTLS are tested under eight different construction environments and the test results confirm the system’s strong potential for improving the accuracy of real-time location tracking in construction projects, thus enhancing construction performance.

  9. Complex Biochemistry and Biotechnological Production of Betalains

    Directory of Open Access Journals (Sweden)

    Marijana Krsnik-Rasol

    2011-01-01

    Full Text Available The demand for natural food colourants is increasing because of public awareness of their health benefits. Betalains are nitrogen-containing plant pigments whose colours range from red-violet betacyanins to yellow betaxanthins. They are used for colouring dairy products, meat and frozen desserts. Betalains have attracted additional interest because of their antioxidative, anti-inflammatory and anticarcinogenic properties. The main source of commercially produced betalains is red beet root, but alternative sources are found in plants from the Amaranthaceae and Cactaceae families. Another alternative source is plant cell culture in bioreactors, although optimization of pigment production seems necessary. In this paper we synthesize the results of recent studies on betalain biosynthesis, chemical properties, sources, biotechnology and applications.

  10. Multicriteria Selection of Optimal Location of TCSC in a Competitive Energy Market

    Science.gov (United States)

    Alomoush, Muwaffaq I.

    2010-05-01

    The paper investigates selection of the best location of thyristor-controlled series compensator (TCSC) in a transmission system from many candidate locations in a competitive energy market such that the TCSC causes a net valuable impact on congestion management outcome, transmission utilization, transmission losses, voltage stability, degree of fulfillment of spot market contracts, and system security. The problem is treated as a multicriteria decision-making process such that the candidate locations of TCSC are the alternatives and the conflicting objectives are the outcomes of the dispatch process, which may have different importance weights. The paper proposes some performance indices that the dispatch decision-making entity can use to measure market dispatch outcomes of each alternative. Based on agreed-upon preferences, the measures presented may help the decision maker compare and rank dispatch scenarios to ultimately decide which location is the optimal one. To solve the multicriteria decision, we use the preference ranking organization method for enrichment evaluations (PROMETHEE), which is a multicriteria decision support method that can handle complex conflicting-objective decision-making processes.

  11. Dignity at the end of our days: personal, familial, and cultural location.

    Science.gov (United States)

    McDonald, Michael

    2004-01-01

    The desire to be treated with dignity, particularly at the end of one's life, is a fairly universal preference found in most cultures. Such treatment requires positive actions of respect in the behaviour of others toward the dying and the dead. It also involves negative actions, particularly refraining from doing "dignatory harms" to the dead and the dying. Yet it is not always easy for clinicians and researchers who deal with the dying and dead to decide on appropriate action or inaction. I suggest that such decision making can be helped by locating the dying person along three dimensions: the personal, the familial, and the cultural. These elements are interrelated in complex ways that need to be unpacked in context. Thus, one person may locate herself within a familial context while a sibling may locate himself against that context. While locating individuals along the three dimensions suggested does not "solve" ethical problems, it should help clinicians in understanding and dealing more compassionately with the dead, the dying, their families, and their communities.

  12. Radiation damage to DNA in DNA-protein complexes.

    Science.gov (United States)

    Spotheim-Maurizot, M; Davídková, M

    2011-06-03

    The most aggressive product of water radiolysis, the hydroxyl (OH) radical, is responsible for the indirect effect of ionizing radiations on DNA in solution and aerobic conditions. According to radiolytic footprinting experiments, the resulting strand breaks and base modifications are inhomogeneously distributed along the DNA molecule irradiated free or bound to ligands (polyamines, thiols, proteins). A Monte-Carlo based model of simulation of the reaction of OH radicals with the macromolecules, called RADACK, allows calculating the relative probability of damage of each nucleotide of DNA irradiated alone or in complexes with proteins. RADACK calculations require the knowledge of the three dimensional structure of DNA and its complexes (determined by X-ray crystallography, NMR spectroscopy or molecular modeling). The confrontation of the calculated values with the results of the radiolytic footprinting experiments together with molecular modeling calculations show that: (1) the extent and location of the lesions are strongly dependent on the structure of DNA, which in turns is modulated by the base sequence and by the binding of proteins and (2) the regions in contact with the protein can be protected against the attack by the hydroxyl radicals via masking of the binding site and by scavenging of the radicals. 2011 Elsevier B.V. All rights reserved.

  13. The building blocks of economic complexity

    Science.gov (United States)

    Hidalgo, César A.; Hausmann, Ricardo

    2009-01-01

    For Adam Smith, wealth was related to the division of labor. As people and firms specialize in different activities, economic efficiency increases, suggesting that development is associated with an increase in the number of individual activities and with the complexity that emerges from the interactions between them. Here we develop a view of economic growth and development that gives a central role to the complexity of a country's economy by interpreting trade data as a bipartite network in which countries are connected to the products they export, and show that it is possible to quantify the complexity of a country's economy by characterizing the structure of this network. Furthermore, we show that the measures of complexity we derive are correlated with a country's level of income, and that deviations from this relationship are predictive of future growth. This suggests that countries tend to converge to the level of income dictated by the complexity of their productive structures, indicating that development efforts should focus on generating the conditions that would allow complexity to emerge to generate sustained growth and prosperity. PMID:19549871

  14. Cordilleran metamorphic core complexes and their uranium favorability

    International Nuclear Information System (INIS)

    Coney, P.J.; Reynolds, S.J.

    1980-11-01

    The objective of this report is to provide a descriptive body of knowledge on Cordilleran metamorphic core complexes including their lithologic and structural characteristics, their distribution within the Cordillera, and their evolutionary history and tectonic setting. The occurrence of uranium in the context of possibility for uranium concentration is also examined. This volume contains appendices of the following: annotated bibliography of Cordilleran metamorphic core complexes; annotated bibliography of the uranium favorability of Cordilleran metamorphic core complexes; uranium occurrences in the Cordilleran metamorphic core complex belt; and geology, uranium favorability, uranium occurrences and tectonic maps of individual Cordilleran metamorphic core complexes; and locations, lithologic descriptions, petrographic information and analytical data for geochemical samples

  15. Unusually large erupted complex odontoma: A rare case report

    Energy Technology Data Exchange (ETDEWEB)

    Bagewadi, Shivanand B.; Kukreja, Rahul; Suma, Gundareddy N.; Yadav, Bhawn; Sharma, Havi [Dept. of Oral Medicine and Radiology, ITS Centre for Dental Studies and Research, Murad Nagar (India)

    2015-03-15

    Odontomas are nonaggressive, hamartomatous developmental malformations composed of mature tooth substances and may be compound or complex depending on the extent of morphodifferentiation or on their resemblance to normal teeth. Among them, complex odontomas are relatively rare tumors. They are usually asymptomatic in nature. Occasionally, these tumors become large, causing bone expansion followed by facial asymmetry. Odontoma eruptions are uncommon, and thus far, very few cases of erupted complex odontomas have been reported in the literature. Here, we report the case of an unusually large, painless, complex odontoma located in the right posterior mandible.

  16. Structuring requirements as necessary premise for customer-oriented development of complex products: A generic approach

    Directory of Open Access Journals (Sweden)

    Sandra Klute

    2011-10-01

    Full Text Available Purpose: Complex products like for example intra-logistical facilities make high demands on developers and producers and involve high investment and operating costs. When planning and developing and also making buying decisions the facility utilization and the thus ensuing requirements on the facility and its components are inadequately considered to date. Nevertheless, with regard to customer-directed product design, these requirements must all be taken into account – especially as they can contribute to possible savings. In this context, it is necessary to survey and systematically regard requirements from a large number of areas like for example the operator, the facility producer and also requirements of external parties such as the law and to implement into adequate product characteristics to produce customer-oriented products. This is, however, a difficult task because of the diversity of stakeholders involved and their numerous and often divergent requirements. Therefore, it is essential to structure the requirements, so that planners and developers are able to manage the large amount of information. Structure models can be used in this context to cluster requirements. Within the German Collaborative Research Centre 696 a 10-dimensional model has been developed. This model allows structuring of all requirements on intra-logistical facilities or respectively complex products in general. In the context of dealing with hundreds of data records, structuring requirements is mandatory to achieve accuracy, clarity and consequently satisfactory results when transforming requirements into product characteristics which fit customer needs. In the paper an excerpt of this model is presented. Design/methodology/approach: In literature a multitude of methods which deal with the topic of structuring exist. The methods have been analysed regarding their purpose and their level of specification, i.e. the number of differentiated categories, to check if

  17. Experimental and computational fluid dynamics studies of mixing of complex oral health products

    Science.gov (United States)

    Cortada-Garcia, Marti; Migliozzi, Simona; Weheliye, Weheliye Hashi; Dore, Valentina; Mazzei, Luca; Angeli, Panagiota; ThAMes Multiphase Team

    2017-11-01

    Highly viscous non-Newtonian fluids are largely used in the manufacturing of specialized oral care products. Mixing often takes place in mechanically stirred vessels where the flow fields and mixing times depend on the geometric configuration and the fluid physical properties. In this research, we study the mixing performance of complex non-Newtonian fluids using Computational Fluid Dynamics models and validate them against experimental laser-based optical techniques. To this aim, we developed a scaled-down version of an industrial mixer. As test fluids, we used mixtures of glycerol and a Carbomer gel. The viscosities of the mixtures against shear rate at different temperatures and phase ratios were measured and found to be well described by the Carreau model. The numerical results were compared against experimental measurements of velocity fields from Particle Image Velocimetry (PIV) and concentration profiles from Planar Laser Induced Fluorescence (PLIF).

  18. Complexity management in the food industry

    DEFF Research Database (Denmark)

    Herbert-Hansen, Zaza Nadja Lee; Jacobsen, Peter

    2017-01-01

    The many stakeholders in the food industry with their diverse interests make this industry complex and interesting to work with. There are four main stakeholders; 1) The customers with their increased demand for customized products, quick delivery times and increased responsiveness, 2) The author......The many stakeholders in the food industry with their diverse interests make this industry complex and interesting to work with. There are four main stakeholders; 1) The customers with their increased demand for customized products, quick delivery times and increased responsiveness, 2...... this complexity and finding a method for using these complexity factors in economic calculations. The research question this paper seeks to address is therefore “Which complexity factors can be quantified in the food industry and how can they be used in economic calculations?” A case study of a SME Danish bread...... producer will address the research question due to the explorative nature of this study and the limited amount of previous research within this field....

  19. A multiple-location model for natural gas forward curves

    International Nuclear Information System (INIS)

    Buffington, J.C.

    1999-06-01

    This thesis presents an approach for financial modelling of natural gas in which connections between locations are incorporated and the complexities of forward curves in natural gas are considered. Apart from electricity, natural gas is the most volatile commodity traded. Its price is often dependent on the weather and price shocks can be felt across several geographic locations. This modelling approach incorporates multiple risk factors that correspond to various locations. One of the objectives was to determine if the model could be used for closed-form option prices. It was suggested that an adequate model for natural gas must consider 3 statistical properties: volatility term structure, backwardation and contango, and stochastic basis. Data from gas forward prices at Chicago, NYMEX and AECO were empirically tested to better understand these 3 statistical properties at each location and to verify if the proposed model truly incorporates these properties. In addition, this study examined the time series property of the difference of two locations (the basis) and determines that these empirical properties are consistent with the model properties. Closed-form option solutions were also developed for call options of forward contracts and call options on forward basis. The options were calibrated and compared to other models. The proposed model is capable of pricing options, but the prices derived did not pass the test of economic reasonableness. However, the model was able to capture the effect of transportation as well as aspects of seasonality which is a benefit over other existing models. It was determined that modifications will be needed regarding the estimation of the convenience yields. 57 refs., 2 tabs., 7 figs., 1 append

  20. Searching and Extracting Data from the EMBL-EBI Complex Portal.

    Science.gov (United States)

    Meldal, Birgit H M; Orchard, Sandra

    2018-01-01

    The Complex Portal ( www.ebi.ac.uk/complexportal ) is an encyclopedia of macromolecular complexes. Complexes are assigned unique, stable IDs, are species specific, and list all participating members with links to an appropriate reference database (UniProtKB, ChEBI, RNAcentral). Each complex is annotated extensively with its functions, properties, structure, stoichiometry, tissue expression profile, and subcellular location. Links to domain-specific databases allow the user to access additional information and enable data searching and filtering. Complexes can be saved and downloaded in PSI-MI XML, MI-JSON, and tab-delimited formats.

  1. Production of bioactive soluble interleukin-15 in complex with interleukin-15 receptor alpha from a conditionally-replicating oncolytic HSV-1.

    Directory of Open Access Journals (Sweden)

    David C Gaston

    Full Text Available Oncolytic type-1 herpes simplex viruses (oHSVs lacking the γ134.5 neurovirulence gene are being evaluated for treatment of a variety of malignancies. oHSVs replicate within and directly kill permissive cancer cells. To augment their anti-tumor activity, oHSVs have been engineered to express immunostimulatory molecules, including cytokines, to elicit tumor-specific immune responses. Interleukin-15 (IL-15 holds potential as an immunotherapeutic cytokine because it has been demonstrated to promote both natural killer (NK cell-mediated and CD8(+ T cell-mediated cytotoxicity against cancer cells. The purpose of these studies was to engineer an oHSV producing bioactive IL-15. Two oHSVs were constructed encoding murine (mIL-15 alone (J100 or with the mIL-15 receptor α (mIL-15Rα, J100D to determine whether co-expression of these proteins is required for production of bioactive mIL-15 from oHSV. The following were demonstrated: i both oHSVs retain replication competence and cytotoxicity in permissive tumor cell lines. ii Enhanced production of mIL-15 was detected in cell lysates of neuro-2a cells following J100D infection as compared to J100 infection, suggesting that mIL-15Rα improved mIL-15 production. iii Soluble mIL-15 in complex with mIL-15Rα was detected in supernates from J100D-infected, but not J100-infected, neuro-2a, GL261, and CT-2A cells. These cell lines vary in permissiveness to oHSV replication and cytotoxicity, demonstrating soluble mIL-15/IL-15Rα complex production from J100D was independent of direct oHSV effects. iv The soluble mIL-15/IL-15Rα complex produced by J100D was bioactive, stimulating NK cells to proliferate and reduce the viability of syngeneic GL261 and CT-2A cells. v J100 and J100D were aneurovirulent inasmuch as no neuropathologic effects were documented following direct inoculation into brains of CBA/J mice at up to 1x10(7 plaque forming units. The production of mIL-15/mIL-15Rα from multiple tumor lines, as well

  2. Internet Geo-Location

    Science.gov (United States)

    2017-12-01

    INTERNET GEO-LOCATION DUKE UNIVERSITY DECEMBER 2017 FINAL TECHNICAL REPORT APPROVED FOR PUBLIC RELEASE; DISTRIBUTION UNLIMITED STINFO COPY AIR...REPORT TYPE FINAL TECHNICAL REPORT 3. DATES COVERED (From - To) MAY 2014 – MAY 2017 4. TITLE AND SUBTITLE INTERNET GEO-LOCATION 5a. CONTRACT...of SpeedTest servers that are used by end users to measure the speed of their Internet connection. The servers log the IP address and the location

  3. Rare earth element mineralogy, geochemistry, and preliminary resource assessment of the Khanneshin carbonatite complex, Helmand Province, Afghanistan

    Science.gov (United States)

    Tucker, Robert D.; Belkin, Harvey E.; Schulz, Klaus J.; Peters, Stephen G.; Buttleman, Kim P.

    2011-01-01

    There is increased concern about the future availability of rare earth elements (REE) because of China's dominance as the supplier of more than 95 percent of world REE output, their decision to restrict exports of rare earth products, and the rapid increase in world-wide consumption of rare earth product. As a result, countries such as the United States, Japan, and member nations of the European Union face a future of tight supplies and high prices for rare earth products unless other sources of REE are found and developed (Long and others, 2010; U.S. Geological Survey, 2011, p. 128-129, 184-185). We report and describe a significant new deposit of light rare earth elements (LREE), estimated at 1 Mt, within the Khanneshin carbonatite complex of south Afghanistan. The potential resource is located in a remote and rugged part of the igneous complex in a region previously identified by Soviet geologists in the 1970s. This report reviews the geologic setting of LREE deposit, presents new geochemical data documenting the grade of LREE mineralization, briefly describes the mineralogy and mineralogical associations of the deposit, and presents a preliminary estimate of LREE resources based on our current understanding of the geology.

  4. Quantifying Complexity in Quantum Phase Transitions via Mutual Information Complex Networks.

    Science.gov (United States)

    Valdez, Marc Andrew; Jaschke, Daniel; Vargas, David L; Carr, Lincoln D

    2017-12-01

    We quantify the emergent complexity of quantum states near quantum critical points on regular 1D lattices, via complex network measures based on quantum mutual information as the adjacency matrix, in direct analogy to quantifying the complexity of electroencephalogram or functional magnetic resonance imaging measurements of the brain. Using matrix product state methods, we show that network density, clustering, disparity, and Pearson's correlation obtain the critical point for both quantum Ising and Bose-Hubbard models to a high degree of accuracy in finite-size scaling for three classes of quantum phase transitions, Z_{2}, mean field superfluid to Mott insulator, and a Berzinskii-Kosterlitz-Thouless crossover.

  5. Quantifying Complexity in Quantum Phase Transitions via Mutual Information Complex Networks

    Science.gov (United States)

    Valdez, Marc Andrew; Jaschke, Daniel; Vargas, David L.; Carr, Lincoln D.

    2017-12-01

    We quantify the emergent complexity of quantum states near quantum critical points on regular 1D lattices, via complex network measures based on quantum mutual information as the adjacency matrix, in direct analogy to quantifying the complexity of electroencephalogram or functional magnetic resonance imaging measurements of the brain. Using matrix product state methods, we show that network density, clustering, disparity, and Pearson's correlation obtain the critical point for both quantum Ising and Bose-Hubbard models to a high degree of accuracy in finite-size scaling for three classes of quantum phase transitions, Z2, mean field superfluid to Mott insulator, and a Berzinskii-Kosterlitz-Thouless crossover.

  6. Model-based flaw localization from perturbations in the dynamic response of complex mechanical structures

    Energy Technology Data Exchange (ETDEWEB)

    Chambers, D H

    2009-02-24

    A new method of locating structural damage using measured differences in vibrational response and a numerical model of the undamaged structure has been presented. This method is particularly suited for complex structures with little or no symmetry. In a prior study the method successively located simulated damage from measurements of the vibrational response on two simple structures. Here we demonstrate that it can locate simulated damage in a complex structure. A numerical model of a complex structure was used to calculate the structural response before and after the introduction of a void. The method can now be considered for application to structures of programmatic interest. It could be used to monitor the structural integrity of complex mechanical structures and assemblies over their lifetimes. This would allow early detection of damage, when repair is relatively easy and inexpensive. It would also allow one to schedule maintenance based on actual damage instead of a time schedule.

  7. Location Privacy with Randomness Consistency

    Directory of Open Access Journals (Sweden)

    Wu Hao

    2016-10-01

    Full Text Available Location-Based Social Network (LBSN applications that support geo-location-based posting and queries to provide location-relevant information to mobile users are increasingly popular, but pose a location-privacy risk to posts. We investigated existing LBSNs and location privacy mechanisms, and found a powerful potential attack that can accurately locate users with relatively few queries, even when location data is well secured and location noise is applied. Our technique defeats previously proposed solutions including fake-location detection and query rate limits.

  8. Cyclomatic Complexity: theme and variations

    Directory of Open Access Journals (Sweden)

    Brian Henderson-Sellers

    1993-11-01

    Full Text Available Focussing on the "McCabe family" of measures for the decision/logic structure of a program, leads to an evaluation of extensions to modularization, nesting and, potentially, to object-oriented program structures. A comparison of rated, operating and essential complexities of programs suggests two new metrics: "inessential complexity" as a measure of unstructuredness and "product complexity" as a potential objective measure of structural complexity. Finally, nesting and abstraction levels are considered, especially as to how metrics from the "McCabe family" might be applied in an object-oriented systems development environment.

  9. CURRENT AND KINETIC HELICITY OF LONG-LIVED ACTIVITY COMPLEXES

    International Nuclear Information System (INIS)

    Komm, Rudolf; Gosain, Sanjay

    2015-01-01

    We study long-lived activity complexes and their current helicity at the solar surface and their kinetic helicity below the surface. The current helicity has been determined from synoptic vector magnetograms from the NSO/SOLIS facility, and the kinetic helicity of subsurface flows has been determined with ring-diagram analysis applied to full-disk Dopplergrams from NSO/GONG and SDO/HMI. Current and kinetic helicity of activity complexes follow the hemispheric helicity rule with mainly positive values (78%; 78%, respectively, with a 95% confidence level of 31%) in the southern hemisphere and negative ones (80%; 93%, respectively, with a 95% confidence level of 22% and 14%, respectively) in the northern hemisphere. The locations with the dominant sign of kinetic helicity derived from Global Oscillation Network Group (GONG) and SDO/HMI data are more organized than those of the secondary sign even if they are not part of an activity complex, while locations with the secondary sign are more fragmented. This is the case for both hemispheres even for the northern one where it is not as obvious visually due to the large amount of magnetic activity present as compared to the southern hemisphere. The current helicity shows a similar behavior. The dominant sign of current helicity is the same as that of kinetic helicity for the majority of the activity complexes (83% with a 95% confidence level of 15%). During the 24 Carrington rotations analyzed here, there is at least one longitude in each hemisphere where activity complexes occur repeatedly throughout the epoch. These ''active'' longitudes are identifiable as locations of strong current and kinetic helicity of the same sign

  10. Inclusion complexation of tetrabutylammonium iodide by cyclodextrins

    Indian Academy of Sciences (India)

    Biswajit Datta

    Host-guest inclusion complex of an ionic solid (tetrabutyl ammonium iodide) with α- and β- cyclodextrin has been ... tions.2 CDs are cyclic oligomer of α-D-glucose having numerous of ... of locating at the interface of two phases (liquid–liquid.

  11. World resources of oil products

    International Nuclear Information System (INIS)

    Bonnaterre, Raymond

    2014-01-01

    In a first part, the author outlines that the issue of density of an oil product raises the question of the validity of a counting approach based on volumes. As oil industries produce always less heavy products and always more light products, this means that always less oil is needed to produce a gallon or a litre of fuel out of a refinery. The author comments the evolution of crude oil extraction. In a second part, he outlines that hydrocarbon productions become always more complex with respect to their origin. Thus, during gas extraction, humid gases are recovered which contain an important part of hydrocarbons similar to light oil. These aspects and the development of shale gas exploitation will make the USA the first oil producer in the world whereas they still have to import heavy oil to feed their refineries. He discusses the level of reserves and production costs with respect to the product type or its extraction location. He discusses the evolution of the estimates of world ultimately recoverable resources (synthesis processes excluded). He comments the level of condensate extraction ratio of the main shale gas fields in the USA and outlines the cost of natural gas imports for France. He outlines the importance of GTL (gas to liquid) processes, the increasing importance of bio-fuels (notably isobutanol biosynthesis and terpene biosynthesis). In the third part, the author states that the barrel price should keep on increasing and, in the fourth part, proposes a list of issues which will impact the future of the oil market

  12. First LOCSMITH locations of deep moonquakes

    Science.gov (United States)

    Hempel, S.; Knapmeyer, M.; Sens-Schönfelder, C.; Oberst, J.

    2008-09-01

    stacking we developed a complex multiparameter correlation algorithm to calculate the optimum time shift. Results We present relocations of selected deep moonquakes in context of data availability and quality. Previous locations are often contained in our location clouds, but realistic location uncertainties allow large deviations from the best fitting solutions, including locations on the far side of the Moon. Perspective By developing new methods for data processing and using the LOCSMITH locating algorithm we hope to reduce the location uncertainty sufficiently to make sure that all sources are on the near side, or to prove a far side origin of some of them. This would answer questions of hemispheric symmetry of lunar deep seismicity and the Moon's internal structure. References [1] Knapmeyer (2008) accepted to GJI. [2] Nakamura (2005) JGR, 110, E01001. [3] Lognonné (2003) EPSL, 211, 2744. [4] Bulow (2005) JGR, 110, E10003. [5] Sonnemann (2005) EGU05A07960. [6] Hempel, Knapmeyer, Oberst (2008) EGU2008A07989.

  13. Joint Optimal Production Planning for Complex Supply Chains Constrained by Carbon Emission Abatement Policies

    Directory of Open Access Journals (Sweden)

    Longfei He

    2014-01-01

    Full Text Available We focus on the joint production planning of complex supply chains facing stochastic demands and being constrained by carbon emission reduction policies. We pick two typical carbon emission reduction policies to research how emission regulation influences the profit and carbon footprint of a typical supply chain. We use the input-output model to capture the interrelated demand link between an arbitrary pair of two nodes in scenarios without or with carbon emission constraints. We design optimization algorithm to obtain joint optimal production quantities combination for maximizing overall profit under regulatory policies, respectively. Furthermore, numerical studies by featuring exponentially distributed demand compare systemwide performances in various scenarios. We build the “carbon emission elasticity of profit (CEEP” index as a metric to evaluate the impact of regulatory policies on both chainwide emissions and profit. Our results manifest that by facilitating the mandatory emission cap in proper installation within the network one can balance well effective emission reduction and associated acceptable profit loss. The outcome that CEEP index when implementing Carbon emission tax is elastic implies that the scale of profit loss is greater than that of emission reduction, which shows that this policy is less effective than mandatory cap from industry standpoint at least.

  14. Fuel failure detection and location methods in CAGRs

    International Nuclear Information System (INIS)

    Harris, A.M.

    1982-06-01

    The release of fission products from AGR fuel failures and the way in which the signals from such failures must be detected against the background signal from uranium contamination of the fuel is considered. Theoretical assessments of failure detection are used to show the limitations of the existing Electrostatic Wire Precipitator Burst Can Detection system (BCD) and how its operating parameters can be optimised. Two promising alternative methods, the 'split count' technique and the use of iodine measurements, are described. The results of a detailed study of the mechanical and electronic performance of the present BCD trolleys are given. The limited experience of detection and location of two fuel failures in CAGR using conventional and alternative methods is reviewed. The larger failure was detected and located using the conventional BCD equipment with a high confidence level. It is shown that smaller failures may not be easy to detect and locate using the current BCD equipment, and the second smaller failure probably remained in the reactor for about a year before it was discharged. The split count technique used with modified BCD equipment was able to detect the smaller failure after careful inspection of the data. (author)

  15. Heat penetration and thermocouple location in home canning.

    Science.gov (United States)

    Etzel, Mark R; Willmore, Paola; Ingham, Barbara H

    2015-01-01

    We processed applesauce, tomato juice, and cranberries in pint jars in a boiling water canner to test thermal processing theories against home canning of high-acid foods. For each product, thermocouples were placed at various heights in the jar. Values for f h (heating), f cl (cooling), and F 82.2°C (lethality) were determined for each thermocouple location, and did not depend substantially on thermocouple location in accordance with heat transfer theory. There was a cold spot in the jar, but the cold spot during heating became the hot spot during cooling. During heating, the geometric center was the last to heat, and remained coldest the longest, but during coooling, it was also the last to cool, and remained hottest the longest. The net effect was that calculated lethality in home canning was not affected by thermocouple location. Most of the lethality during home canning occurred during air cooling, making cooling of home canned foods of great importance. Calculated lethality was far greater than the required 5-log reduction of spores in tomato juice and vegetative cells in cranberries, suggesting a wide margin of safety for approved home-canning processes for high-acid foods.

  16. Smartphones as locative media

    CERN Document Server

    Frith, Jordan

    2015-01-01

    Smartphone adoption has surpassed 50% of the population in more than 15 countries, and there are now more than one million mobile applications people can download to their phones. Many of these applications take advantage of smartphones as locative media, which is what allows smartphones to be located in physical space. Applications that take advantage of people's location are called location-based services, and they are the focus of this book. Smartphones as locative media raise important questions about how we understand the complicated relationship between the Internet and physical space

  17. Novel Reactivity Of The Cationic Complex

    International Nuclear Information System (INIS)

    Wang, J.; Dash, A.K.; Eisen, AM.; Berthet, J.C.; Ephritikhine, M.

    2002-01-01

    The catalytic chemistry of electrophilic d 0 /f organometallic complexes is nowadays under intense investigation, reaching a high level of sophistication. General aspects concerning these complexes are concentrated for most studies to the functionalization of unsaturated organic molecules. To cite an instance, the actinide-promoted oligomerization of terminal alkynes is of essential present concern since it may introduce to a diversity of organic enynes and oligoacetylene products that are valuable synthons for the synthesis of natural products. Enynes are the simplest oligomerization products of alkynes. We have demonstrated that organoactinides complexes of the type [Cp* 2 AnMe 2 AnMe 2 ] (Cp* = C 5 Me 5 ; An = U, Th) are active catalysts for the linear oligomerization of terminal alkynes and the extent of oligomerization was found to be strongly dependent on the electronic and steric properties of the alkyne substituents. Bulky alkynes were reacted with high regioselectivity toward dimer and/or trimers whereas for non-bulky alkynes, these compounds were transformed into oligomers with a total deficiency of regioselectivity. The addition of primary amines to the catalytic cycle, for An = Th, granted the chemoselective formation of dimers, chemoselectively, whereas for An = U, this control was not succeeded. In distinction to the neutral organoactinide complexes, homogeneous cationic d 0 /f n actinide complexes have been used as in the homogeneous polymerization of olefins as extremely active catalysts. Hence, the catalytic alkyne oligomerization is a opportune route to explore insertions and σ-bond metathesis reactivity of complexes. We have recently shown that the reaction of terminal alkynes (RC≡CH), promoted by [(Et 2 N) 3 U][BPh 4 ], in toluene, produces efficiently mostly the gem dimers (for R = Me, i Pr and n Bu) as the major products, whereas for bulky alkynes (R = t MS or t Bu) small amounts of the cis dimer was concomitantly obtained. A plausible

  18. Dealing with Insufficient Location Fingerprints in Wi-Fi Based Indoor Location Fingerprinting

    Directory of Open Access Journals (Sweden)

    Kai Dong

    2017-01-01

    Full Text Available The development of the Internet of Things has accelerated research in the indoor location fingerprinting technique, which provides value-added localization services for existing WLAN infrastructures without the need for any specialized hardware. The deployment of a fingerprinting based localization system requires an extremely large amount of measurements on received signal strength information to generate a location fingerprint database. Nonetheless, this requirement can rarely be satisfied in most indoor environments. In this paper, we target one but common situation when the collected measurements on received signal strength information are insufficient, and show limitations of existing location fingerprinting methods in dealing with inadequate location fingerprints. We also introduce a novel method to reduce noise in measuring the received signal strength based on the maximum likelihood estimation, and compute locations from inadequate location fingerprints by using the stochastic gradient descent algorithm. Our experiment results show that our proposed method can achieve better localization performance even when only a small quantity of RSS measurements is available. Especially when the number of observations at each location is small, our proposed method has evident superiority in localization accuracy.

  19. Characterization of the Unusual Product from the Reaction between Cobalt(II) Chloride, Ethane-1,2-diamine, and Hydrochloric Acid: An Undergraduate Project Involving an Unknown Metal Complex.

    Science.gov (United States)

    Curtis, Neil F.; And Others

    1986-01-01

    Discusses the need for student research-type chemistry projects based upon "unknown" metal complexes. Describes an experiment involving the product from the reaction between cobalt(II) chloride, ethane-1,2-diamine (en) and concentrated hydrochloric acid. Outlines the preparation of the cobalt complex, along with procedure, results and…

  20. ACCURACY EVALUATION OF THE OBJECT LOCATION VISUALIZATION FOR GEO-INFORMATION AND DISPLAY SYSTEMS OF MANNED AIRCRAFTS NAVIGATION COMPLEXES

    Directory of Open Access Journals (Sweden)

    M. O. Kostishin

    2014-01-01

    Full Text Available The paper deals with the issue of accuracy estimating for the object location display in the geographic information systems and display systems of manned aircrafts navigation complexes. Application features of liquid crystal screens with a different number of vertical and horizontal pixels are considered at displaying of geographic information data on different scales. Estimation display of navigation parameters values on board the aircraft is done in two ways: a numeric value is directly displayed on the screen of multi-color indicator, and a silhouette of the object is formed on the screen on a substrate background, which is a graphical representation of area map in the flight zone. Various scales of area digital map display currently used in the aviation industry have been considered. Calculation results of one pixel scale interval, depending on the specifications of liquid crystal screen and zoom of the map display area on the multifunction digital display, are given. The paper contains experimental results of the accuracy evaluation for area position display of the aircraft based on the data from the satellite navigation system and inertial navigation system, obtained during the flight program run of the real object. On the basis of these calculations a family of graphs was created for precision error display of the object reference point position using the onboard indicators with liquid crystal screen with different screen resolutions (6 "×8", 7.2 "×9.6", 9"×12" for two map display scales (1:0 , 25 km, 1-2 km. These dependency graphs can be used both to assess the error value of object area position display in existing navigation systems and to calculate the error value in upgrading facilities.

  1. Law Enforcement Locations

    Data.gov (United States)

    Kansas Data Access and Support Center — Law Enforcement Locations in Kansas Any location where sworn officers of a law enforcement agency are regularly based or stationed. Law enforcement agencies "are...

  2. The use of spices in the production of traditional cheeses

    Directory of Open Access Journals (Sweden)

    Renata Josipović

    2016-01-01

    Full Text Available Cheese is a highly valued dairy product worldwide, with a special focus on traditional cheeses, not only for their basic nutritive purposes but also as a part of the culture and characteristics of a certain country. Owing to the geographical location as well as the climate and vegetation diversity, in certain regions of Croatia the production of various traditional cheeses using spices was developed. Spices are either added to the cheese curd which is then formed, or cheese is wrapped into plant leaves. Sometimes spices are also applied onto the surface of the cheese, and only in rare cases spices are added into the curd. Spices added to cheese improve sensory characteristics, increase the stability and shelf life but also increase the nutritional value. The chemical composition of spices is very complex and every spice has a specific and dominant ingredient that contributes to the flavour of the product and/or its antimicrobial and antioxidant activity. This paper provides an overview of spices and aromatic herbs as natural preservatives that are used in the production of traditional cheeses.

  3. Theory of multinationals' choice of technique and locational decisions

    Energy Technology Data Exchange (ETDEWEB)

    de Meza, D.

    1979-01-01

    A neoclassical explanation is presented of the failure of multinational corporations (MNCs) to adapt their technology in low-wage countries. MNCs are found to employ more labor-intensive techniques and pay lower wages than companies serving only domestic markets if transport and tariff costs are present. Product locational decisions are also analyzed. 6 references.

  4. Green product development : What does the country product space imply?

    NARCIS (Netherlands)

    Fraccascia, Luca; Giannoccaro, Ilaria; Albino, Vito

    This paper contributes to green product development by identifying the green products with the highest potential for growth in a country. To address our aim, we use the concept of product proximity and product space and, borrowing from the results of recent studies on complexity economics, we

  5. Fetus in fetu and OEIS complex (Cloacal exstrophy)

    International Nuclear Information System (INIS)

    Casirola, E.A.; Erbes, H.N.; Menzio, Monica; Diorio, Liliana; Di Paulo, Consuelo

    2004-01-01

    A 36 weeks newborn with fetiform mass located in the pelvic region protruding between the lower limbs with epidermis and hair is presented. In the host twin is detected omphalocele, bladder exstrophy, imperforate anus, spinal defects (OEIS complex), bilateral clubfeet and sex not defined by absence of external genitalia. Findings on plain radiograph and CT scan associated to an adequate clinical analysis allowed to characterize the complex malformation. (author)

  6. The features of oil & gas complex's strategic management and hydrocarbon products transportation at developing marine oil & gas fields in Arctic

    Directory of Open Access Journals (Sweden)

    Fadeev А. М.

    2017-12-01

    Full Text Available The paper considers some theoretical and practical issues of strategic management of oil and gas complex at the development of hydrocarbon resources in the Arctic offshore. The analysis of existing approaches in process and project management of oil and gas complex has been carried out taking into account characteristics of offshore projects in the Arctic zone. Considerable attention has been paid to the history and evolution of strategic management as an economic category, functional areas of strategic management at different levels of management have been proposed. The analysis of existing scientific works dedicated to the projects on the Arctic shelf, has shown insufficient development of the strategic management's theory and practice. In particular, the biggest part of the scientific studies is focused on studying issues of the management at the corporate level, at the same time questions at the level of the oil and gas complex are not considered. In existing studies, the project and process approaches to management are often opposed to each other, and according to the authors it is incorrect in relation to the management of the oil and gas complex on the Arctic shelf. The oil and gas complex is a complex and multilevel system that implements unprecedentedly difficult projects in terms of technology. The beginning of hydrocarbon production on the Arctic shelf is inextricably linked with the transportation of extracted raw materials to the processing and marketing sites; it complements the strategic management of the oil and gas complex by the features of organizing efficient transport and logistics solutions.

  7. Nuclear weapons complex

    International Nuclear Information System (INIS)

    Peach, J.D.

    1991-02-01

    In this paper, GAO provides its views on DOE's January 1991 Nuclear Weapons Complex Reconfiguration Study. GAO believes that DOE's new reconfiguration study provides a starting point for reaching agreement on solutions to many of the complex's problems. Key decisions still need to be made about the size of the complex, where to relocate plutonium operations, what technologies should be used for new tritium production, and what to do with excess plutonium. The total cost for reconfiguring and modernizing is still uncertain and some management issues remain unresolved. Congress faces a difficult task in making these decisions given the conflicting demands for scare resources in a time of growing budget deficits and war in the Persian Gulf

  8. Experimental and computational fluid dynamic studies of mixing for complex oral health products

    Science.gov (United States)

    Garcia, Marti Cortada; Mazzei, Luca; Angeli, Panagiota

    2015-11-01

    Mixing high viscous non-Newtonian fluids is common in the consumer health industry. Sometimes this process is empirical and involves many pilot plants trials which are product specific. The first step to study the mixing process is to build on knowledge on the rheology of the fluids involved. In this research a systematic approach is used to validate the rheology of two liquids: glycerol and a gel formed by polyethylene glycol and carbopol. Initially, the constitutive equation is determined which relates the viscosity of the fluids with temperature, shear rate, and concentration. The key variable for the validation is the power required for mixing, which can be obtained both from CFD and experimentally using a stirred tank and impeller of well-defined geometries at different impeller speeds. A good agreement between the two values indicates a successful validation of the rheology and allows the CFD model to be used for the study of mixing in the complex vessel geometries and increased sizes encountered during scale up.

  9. Kalman/Map Filtering-Aided Fast Normalized Cross Correlation-Based Wi-Fi Fingerprinting Location Sensing

    Directory of Open Access Journals (Sweden)

    Yongliang Sun

    2013-11-01

    Full Text Available A Kalman/map filtering (KMF-aided fast normalized cross correlation (FNCC-based Wi-Fi fingerprinting location sensing system is proposed in this paper. Compared with conventional neighbor selection algorithms that calculate localization results with received signal strength (RSS mean samples, the proposed FNCC algorithm makes use of all the on-line RSS samples and reference point RSS variations to achieve higher fingerprinting accuracy. The FNCC computes efficiently while maintaining the same accuracy as the basic normalized cross correlation. Additionally, a KMF is also proposed to process fingerprinting localization results. It employs a new map matching algorithm to nonlinearize the linear location prediction process of Kalman filtering (KF that takes advantage of spatial proximities of consecutive localization results. With a calibration model integrated into an indoor map, the map matching algorithm corrects unreasonable prediction locations of the KF according to the building interior structure. Thus, more accurate prediction locations are obtained. Using these locations, the KMF considerably improves fingerprinting algorithm performance. Experimental results demonstrate that the FNCC algorithm with reduced computational complexity outperforms other neighbor selection algorithms and the KMF effectively improves location sensing accuracy by using indoor map information and spatial proximities of consecutive localization results.

  10. Kalman/Map filtering-aided fast normalized cross correlation-based Wi-Fi fingerprinting location sensing.

    Science.gov (United States)

    Sun, Yongliang; Xu, Yubin; Li, Cheng; Ma, Lin

    2013-11-13

    A Kalman/map filtering (KMF)-aided fast normalized cross correlation (FNCC)-based Wi-Fi fingerprinting location sensing system is proposed in this paper. Compared with conventional neighbor selection algorithms that calculate localization results with received signal strength (RSS) mean samples, the proposed FNCC algorithm makes use of all the on-line RSS samples and reference point RSS variations to achieve higher fingerprinting accuracy. The FNCC computes efficiently while maintaining the same accuracy as the basic normalized cross correlation. Additionally, a KMF is also proposed to process fingerprinting localization results. It employs a new map matching algorithm to nonlinearize the linear location prediction process of Kalman filtering (KF) that takes advantage of spatial proximities of consecutive localization results. With a calibration model integrated into an indoor map, the map matching algorithm corrects unreasonable prediction locations of the KF according to the building interior structure. Thus, more accurate prediction locations are obtained. Using these locations, the KMF considerably improves fingerprinting algorithm performance. Experimental results demonstrate that the FNCC algorithm with reduced computational complexity outperforms other neighbor selection algorithms and the KMF effectively improves location sensing accuracy by using indoor map information and spatial proximities of consecutive localization results.

  11. Combining product attributes with recommendation and shopping location attributes to assess consumer preferences for insect-based food products

    DEFF Research Database (Denmark)

    Alemu, Mohammed Hussen; Olsen, Søren Bøye; Vedel, Suzanne Elizabeth

    2017-01-01

    into consumers' preferences for termite-based food products (TBFPs) using data from a choice experiment survey in Kenya. A novel feature of this paper is that it investigates the combined effects of product-related and contextual attributes, as well as consumer attitudes on preferences for TBFPs. In addition......, the paper focuses on the extent to which preferences may be affected depending on the meal formats, i.e. whether the termites are introduced either as whole insects or as a processed component in a typical daily meal. The results suggest that consumers prefer TBFPs with high nutritional value and especially...... when they are recommended by officials. Results further indicate that affirmative recommendations are particularly important for the processed TBFP, and consumers prefer to buy this type of product in kiosks or supermarkets than at local marketplaces. Despite a considerable degree of preference...

  12. Location model of specialized terminals for soybe an exports in Brazil

    Directory of Open Access Journals (Sweden)

    Alessandra Fraga Dubke

    2011-04-01

    Full Text Available The purpose of this work is the development of a location model for specialized terminals used as transshipment points in the supply chain of soybeans. The theoretical basis of the study relies on the association of a transshipment model with a multi-commodity, multi-facility capacitated location model. The shipping ports might be seen as specialized terminals that add value to the exported products by transforming raw soy grains into soy oil and soy meal. The proposed model also considers service activities in each terminal and the capacity of the maritime ports. Using representative data from the year 2004, the model is illustrated by a small case study, which considers six points of production in inland Brazil, all served by railways, one maritime port on the north and five on the east coast, and three destination ports in Europe and Asia. The study includes a rough sensitivity analysis regarding volumes, capacities, prices, and transportation costs

  13. Different effects of color-based and location-based selection on visual working memory.

    Science.gov (United States)

    Li, Qi; Saiki, Jun

    2015-02-01

    In the present study, we investigated how feature- and location-based selection influences visual working memory (VWM) encoding and maintenance. In Experiment 1, cue type (color, location) and cue timing (precue, retro-cue) were manipulated in a change detection task. The stimuli were color-location conjunction objects, and binding memory was tested. We found a significantly greater effect for color precues than for either color retro-cues or location precues, but no difference between location pre- and retro-cues, consistent with previous studies (e.g., Griffin & Nobre in Journal of Cognitive Neuroscience, 15, 1176-1194, 2003). We also found no difference between location and color retro-cues. Experiment 2 replicated the color precue advantage with more complex color-shape-location conjunction objects. Only one retro-cue effect was different from that in Experiment 1: Color retro-cues were significantly less effective than location retro-cues in Experiment 2, which may relate to a structural property of multidimensional VWM representations. In Experiment 3, a visual search task was used, and the result of a greater location than color precue effect suggests that the color precue advantage in a memory task is related to the modulation of VWM encoding rather than of sensation and perception. Experiment 4, using a task that required only memory for individual features but not for feature bindings, further confirmed that the color precue advantage is specific to binding memory. Together, these findings reveal new aspects of the interaction between attention and VWM and provide potentially important implications for the structural properties of VWM representations.

  14. Simple and complex dysembryoplastic neuroepithelial tumors (DNT) variants: clinical profile, MRI, and histopathology

    Energy Technology Data Exchange (ETDEWEB)

    Campos, Alexandre R.; Clusmann, Hans; Lehe, Marec von; Schramm, Johannes [University of Bonn Medical Center, Department of Neurosurgery, Bonn (Germany); Niehusmann, Pitt; Becker, Albert J. [University of Bonn Medical Center, Department of Neuropathology, Bonn (Germany); Urbach, Horst [University of Bonn Medical Center, Department of Radiology, Bonn (Germany)

    2009-07-15

    Dysembryoplastic neuroepithelial tumors (DNTs) are long-term epilepsy associated tumors subdivided into simple and complex variants. The purpose of this study was to relate different DNT components identified on magnetic resonance imaging (MRI) to histopathological features and to test the hypothesis that glial nodules as a histopathological feature of complex variants induce an occasional glioma misdiagnosis. Clinical, MRI, and histopathologic features of DNTs operated between 1988 and 2008 were reviewed. From a total of 61 DNTs, 48 simple and 13 complex variants were identified. Multiple or single pseudocysts in a cortical/subcortical location with small cysts sometimes separated from the tumor represented the glioneuronal element and were found in all DNTs. FLAIR hyperintense tissue was found between pseudocysts but - in neocortical DNTs - also circumscript in deeper tumor parts. Calcification and hemorrhages in this location occurred in four of 13 complex variants, and one of these patients was also the only one with tumor growth. Patients with complex variants had earlier seizure onset, and complex variants were more often located outside the temporal lobe. Although complex variants represented a higher diagnostic challenge, misdiagnoses also occurred in simple variants. One of five of DNTs showed contrast enhancement, which varied on follow-up studies with enhancing parts becoming nonenhancing and vice versa. The glioneuronal element is readily identifiable on MRI and should be considered to support the DNT diagnosis. Complex DNT variants have a different clinical profile and a more variable histopathological and MRI appearance; however, misdiagnoses occasionally also occur in simple variants. (orig.)

  15. Multi-Criteria Analysis for Solar Farm Location Suitability

    Science.gov (United States)

    Mierzwiak, Michal; Calka, Beata

    2017-12-01

    Currently the number of solar farms, as a type of renewable sources of energy, is growing rapidly. Photovoltaic power stations have many advantages, which is an incentive for their building and development. Solar energy is readily available and inexhaustible, and its production is environmentally friendly. In the present study multiple environmental and economic criteria were taken into account to select a potential photovoltaic farm location, with particular emphasis on: protected areas, land cover, solar radiation, slope angle, proximity to roads, built-up areas, and power lines. Advanced data analysis were used because of the multiplicity of criteria and their diverse influence on the choice of a potential location. They included the spatial analysis, the Weighted Linear Combination Technique (WLC), and the Analytic Hierarchy Process (AHP) as a decisionmaking method. The analysis was divided into two stages. In the first one, the areas where the location of solar farms was not possible were excluded. In the second one, the best locations meeting all environmental and economic criteria were selected. The research was conducted for the Legionowo District, using data from national surveying and mapping resources such as: BDOT10k (Database of Topographic Objects), NMT (Numerical Terrain Model), and lands and buildings register. Finally, several areas meeting the criteria were chosen. The research deals with solar farms with up to 40 kW power. The results of the study are presented as thematic maps. The advantage of the method is its versatility. It can be used not only for any area, but with little modification of the criteria, it can also be applied to choose a location for wind farms.

  16. Forterra Concrete Products, Inc.

    Science.gov (United States)

    The EPA is providing notice of a proposed Administrative Penalty Assessment against Forterra Concrete Products, Inc., a business located at 511 E. John Carpenter Freeway, Irving, TX, 75062, for alleged violations at its facility located at 23600 W. 40th St

  17. Detection of Maillard reaction products by a coupled HPLC-Fraction collector technique and FTIR characterization of Cu(II)-complexation with the isolated species

    Science.gov (United States)

    Ioannou, Aristos; Daskalakis, Vangelis; Varotsis, Constantinos

    2017-08-01

    The isolation of reaction products of asparagine with reducing sugars at alkaline pH and high temperature has been probed by a combination of high performance liquid chromatography (HPLC) coupled with a Fraction Collector. The UV-vis and FTIR spectra of the isolated Maillard reaction products showed structure-sensitive changes as depicted by deamination events and formation of asparagine-saccharide conjugates. The initial reaction species of the Asn-Gluc reaction were also characterized by Density Functional Theory (DFT) methods. Evidence for Cu (II) metal ion complexation with the Maillard reaction products is supported by UV-vis and FTIR spectroscopy.

  18. Project development for mining-metallurgical complexes for production of uranium concentrates - an analysis and a methodology

    International Nuclear Information System (INIS)

    Ajuria G, S.; Blanco P, B.; Pena A, J.; Manzanera Q, C.

    1978-10-01

    Activities comprising the development of a project for a mining-metallurgical complex for production of uranium concentrates, from sampling and evaluation of an orebody until plant start-up, are analyzed. The analysis of the orebody, characterization of the ore, bench scale and pilot plant metallurgical studies, environmental studies and economic analyses of the project are described. The mining project and mine preparation and engineering and construction of the plant are reviewed in less detail. The estimated time lapse for the development of a typical project under ideal conditions is 66 months. A bar diagram is included showing an approximate timetable for each activity. (author)

  19. Tracing trade-related telecouplings in the global land-system using the embodied human appropriation of net primary production framework

    Science.gov (United States)

    Haberl, H.; Kastner, T.; Schaffartzik, A.; Erb, K. H.

    2015-12-01

    Global land-system change is influenced by a complex set of drivers that transcend spatial, institutional and temporal scales. The notion of "telecouplings" is gaining importance in Land System Science as a framework to address that complexity of drivers. One of them is the trade in land-based products, which forges connections between different geographic regions. Trade in land-based products is growing rapidly, thereby creating an increasing spatial disconnect between the locations where primary products (e.g. crops, fodder or timber) are grown and harvested and where the related environmental pressures occur, and the locations where final products (e.g. food, fiber or bioenergy) are consumed. Governing land-related sustainability issues such as GHG emissions or pressures on biodiversity and ecosystems related with land-use changes requires information on trade-related telecouplings, e.g. in order to avoid leakage effects. However, tracing land use (change) related with flows of traded products is challenging, among others due to (a) the lack of easily implementable metrics to account for differences in land quality and land-use intensity, and (b) the lack of satisfactory methods to allocate land to products that are traded and consumed. Drawing from a database derived from FAO statistics that allows tracing bilateral trade flows between ~200 countries at a resolution of ~500 products for the time period 1986-2006, this presentation will discuss how the framework of embodied human appropriation of net primary production (eHANPP) can help tackling these difficult issues. The HANPP framework allows to consistently represent important aspects of land quality and land-use intensity, e.g. natural productivity potential or land-use efficiency. In terms of allocation of land to products, eHANPP is a factor-based approach, and the presentation will discuss differences to alternative methods such as environmentally extended input-output analysis. We will use the available

  20. USE OF MEAT-BONE PASTE AS A PROTEIN SOURCE IN MEAT PRODUCT PRODUCTION

    Directory of Open Access Journals (Sweden)

    A. K. Kakimov

    2016-01-01

    Full Text Available In this paper, the results of the experimental research on developing the technology of a protein complex based on the meat-bone paste and protein-fat-blood emulsion are shown. The technological scheme of meat-bone paste production on the basis of complex grinding meat-bone raw material to bone particle size of 100 ∙10–6 m and further processing of bone particles using reagent, cheese whey, with pH 4,3 is presented. When studying the nutritive and biological value of the protein complex, it was established that the protein complex consisting of the food component from bone and protein-fat-blood emulsion could be used instead of the basic raw material in meat product production. The comparative analysis of the nutritive value of the protein complex and horse meat demonstrated the following results: the amino acid composition of the protein complex showed a balance of the essential amino acids and the high content of the essential amino acids which limit the biological value: lysine, leucine and threonine. The high content of polyunsaturated fatty acids was observed, which justified the biological value of the protein complex.

  1. Location | FNLCR Staging

    Science.gov (United States)

    The Frederick National Laboratory for Cancer Research campus is located 50 miles northwest of Washington, D.C., and 50 miles west of Baltimore, Maryland, in Frederick, Maryland. Satellite locations include leased and government facilities extending s

  2. Low-Frequency Carbon Recombination Lines in the Orion Molecular Cloud Complex

    Science.gov (United States)

    Tremblay, Chenoa D.; Jordan, Christopher H.; Cunningham, Maria; Jones, Paul A.; Hurley-Walker, Natasha

    2018-05-01

    We detail tentative detections of low-frequency carbon radio recombination lines from within the Orion molecular cloud complex observed at 99-129 MHz. These tentative detections include one alpha transition and one beta transition over three locations and are located within the diffuse regions of dust observed in the infrared at 100 μm, the Hα emission detected in the optical, and the synchrotron radiation observed in the radio. With these observations, we are able to study the radiation mechanism transition from collisionally pumped to radiatively pumped within the H ii regions within the Orion molecular cloud complex.

  3. THE Fe II EMISSION IN ACTIVE GALACTIC NUCLEI: EXCITATION MECHANISMS AND LOCATION OF THE EMITTING REGION

    International Nuclear Information System (INIS)

    Marinello, M.; Rodríguez-Ardila, A.; Garcia-Rissmann, A.; Sigut, T. A. A.; Pradhan, A. K.

    2016-01-01

    We present a study of Fe ii emission in the near-infrared region (NIR) for 25 active galactic nuclei (AGNs) to obtain information about the excitation mechanisms that power it and the location where it is formed. We employ an NIR Fe ii template derived in the literature and find that it successfully reproduces the observed Fe ii spectrum. The Fe ii bump at 9200 Å detected in all objects studied confirms that Lyα fluorescence is always present in AGNs. The correlation found between the flux of the 9200 Å bump, the 1 μm lines, and the optical Fe ii implies that Lyα fluorescence plays an important role in Fe ii production. We determined that at least 18% of the optical Fe ii is due to this process, while collisional excitation dominates the production of the observed Fe ii. The line profiles of Fe ii λ10502, O i λ11287, Ca ii λ8664, and Paβ were compared to gather information about the most likely location where they are emitted. We found that Fe ii, O i and Ca ii have similar widths and are, on average, 30% narrower than Paβ. Assuming that the clouds emitting the lines are virialized, we show that the Fe ii is emitted in a region twice as far from the central source than Paβ. The distance, though, strongly varies: from 8.5 light-days for NGC 4051 to 198.2 light-days for Mrk 509. Our results reinforce the importance of the Fe ii in the NIR to constrain critical parameters that drive its physics and the underlying AGN kinematics, as well as more accurate models aimed at reproducing this complex emission

  4. THE Fe II EMISSION IN ACTIVE GALACTIC NUCLEI: EXCITATION MECHANISMS AND LOCATION OF THE EMITTING REGION

    Energy Technology Data Exchange (ETDEWEB)

    Marinello, M. [Universidade Federal de Itajubá, Rua Doutor Pereira Cabral 1303, 37500-903, Itajubá, MG (Brazil); Rodríguez-Ardila, A.; Garcia-Rissmann, A. [Laboratório Nacional de Astrofísica, Rua Estados Unidos 154, Itajubá, MG, 37504-364 (Brazil); Sigut, T. A. A. [The University of Western Ontario, London, ON N6A 3K7 (Canada); Pradhan, A. K., E-mail: murilo.marinello@gmail.com [McPherson Laboratory, The Ohio State University, 140 W. 18th Ave., Columbus, OH 43210-1173 (United States)

    2016-04-01

    We present a study of Fe ii emission in the near-infrared region (NIR) for 25 active galactic nuclei (AGNs) to obtain information about the excitation mechanisms that power it and the location where it is formed. We employ an NIR Fe ii template derived in the literature and find that it successfully reproduces the observed Fe ii spectrum. The Fe ii bump at 9200 Å detected in all objects studied confirms that Lyα fluorescence is always present in AGNs. The correlation found between the flux of the 9200 Å bump, the 1 μm lines, and the optical Fe ii implies that Lyα fluorescence plays an important role in Fe ii production. We determined that at least 18% of the optical Fe ii is due to this process, while collisional excitation dominates the production of the observed Fe ii. The line profiles of Fe ii λ10502, O i λ11287, Ca ii λ8664, and Paβ were compared to gather information about the most likely location where they are emitted. We found that Fe ii, O i and Ca ii have similar widths and are, on average, 30% narrower than Paβ. Assuming that the clouds emitting the lines are virialized, we show that the Fe ii is emitted in a region twice as far from the central source than Paβ. The distance, though, strongly varies: from 8.5 light-days for NGC 4051 to 198.2 light-days for Mrk 509. Our results reinforce the importance of the Fe ii in the NIR to constrain critical parameters that drive its physics and the underlying AGN kinematics, as well as more accurate models aimed at reproducing this complex emission.

  5. Hydraulic Fracturing and Production Optimization in Eagle Ford Shale Using Coupled Geomechanics and Fluid Flow Model

    Science.gov (United States)

    Suppachoknirun, Theerapat; Tutuncu, Azra N.

    2017-12-01

    With increasing production from shale gas and tight oil reservoirs, horizontal drilling and multistage hydraulic fracturing processes have become a routine procedure in unconventional field development efforts. Natural fractures play a critical role in hydraulic fracture growth, subsequently affecting stimulated reservoir volume and the production efficiency. Moreover, the existing fractures can also contribute to the pressure-dependent fluid leak-off during the operations. Hence, a reliable identification of the discrete fracture network covering the zone of interest prior to the hydraulic fracturing design needs to be incorporated into the hydraulic fracturing and reservoir simulations for realistic representation of the in situ reservoir conditions. In this research study, an integrated 3-D fracture and fluid flow model have been developed using a new approach to simulate the fluid flow and deliver reliable production forecasting in naturally fractured and hydraulically stimulated tight reservoirs. The model was created with three key modules. A complex 3-D discrete fracture network model introduces realistic natural fracture geometry with the associated fractured reservoir characteristics. A hydraulic fracturing model is created utilizing the discrete fracture network for simulation of the hydraulic fracture and flow in the complex discrete fracture network. Finally, a reservoir model with the production grid system is used allowing the user to efficiently perform the fluid flow simulation in tight formations with complex fracture networks. The complex discrete natural fracture model, the integrated discrete fracture model for the hydraulic fracturing, the fluid flow model, and the input dataset have been validated against microseismic fracture mapping and commingled production data obtained from a well pad with three horizontal production wells located in the Eagle Ford oil window in south Texas. Two other fracturing geometries were also evaluated to optimize

  6. Locational Pricing to Mitigate Voltage Problems Caused by High PV Penetration

    Directory of Open Access Journals (Sweden)

    Sam Weckx

    2015-05-01

    Full Text Available In this paper, a locational marginal pricing algorithm is proposed to control the voltage in unbalanced distribution grids. The increasing amount of photovoltaic (PV generation installed in the grid may cause the voltage to rise to unacceptable levels during periods of low consumption. With locational prices, the distribution system operator can steer the reactive power consumption and active power curtailment of PV panels to guarantee a safe network operation. Flexible loads also respond to these prices. A distributed gradient algorithm automatically defines the locational prices that avoid voltage problems. Using these locational prices results in a minimum cost for the distribution operator to control the voltage. Locational prices can differ between the three phases in unbalanced grids. This is caused by a higher consumption or production in one of the phases compared to the other phases and provides the opportunity for arbitrage, where power is transferred from a phase with a low price to a phase with a high price. The effect of arbitrage is analyzed. The proposed algorithm is applied to an existing three-phase four-wire radial grid. Several simulations with realistic data are performed.

  7. Production Systems and Supplier Selection

    DEFF Research Database (Denmark)

    Pedraza-Acosta, Isabel; Pilkington, Alan; Barnes, David

    2016-01-01

    strategic stamping suppliers. Findings: Our contribution is the multi-phased production and product innovation process. This is an advance from traditional supplier selection and also an extension of ideas of supplier-located product development as it includes production system development, and complements...

  8. The Processes of Location Study for Developing Economic Zones under Public Private Partnership Model: Country Study on Bangladesh

    Directory of Open Access Journals (Sweden)

    Mahmudul Alam

    2011-02-01

    Full Text Available In spite of the complexity in defining the boundary, the concept of Economic Zones (EZ has been evolved as a way forward for the government of the developing countries for enhancing the national trade. Similarly the recent phenomenon of widespread Public Private Partnership (PPP practices especially in infrastructure sector is also providing a window to develop many of such economic zones through PPP model as EZ typically is capital intensive. Bangladesh has discrete success both under PPP and EZ regime. However, developing EZ under PPP model has few commercial complexities as both the public and private sector need to bear some roles and obligations one of which is selection of appropriate location for EZ development. The location study for PPP EZ development therefore receives paramount attention both from developer and lenders perspective. Such location study generally is not typical project site study by nature; rather it is more economic concentrated. This paper will try to identify the factors that are essential to consider for conducting these location studies based on the examples of Bangladesh. The paper will also identify the appropriate methods and approaches required for successful EZ development through PPP.

  9. Privacy for location-based services

    CERN Document Server

    Ghinita, Gabriel

    2013-01-01

    Sharing of location data enables numerous exciting applications, such as location-based queries, location-based social recommendations, monitoring of traffic and air pollution levels, etc. Disclosing exact user locations raises serious privacy concerns, as locations may give away sensitive information about individuals' health status, alternative lifestyles, political and religious affiliations, etc. Preserving location privacy is an essential requirement towards the successful deployment of location-based applications. These lecture notes provide an overview of the state-of-the-art in locatio

  10. Heterologous Production of an Energy-Conserving Carbon Monoxide Dehydrogenase Complex in the Hyperthermophile Pyrococcus furiosus

    Directory of Open Access Journals (Sweden)

    Gerrit Jan Schut

    2016-01-01

    Full Text Available Carbon monoxide (CO is an important intermediate in anaerobic carbon fixation pathways in acetogenesis and methanogenesis. In addition, some anaerobes can utilize CO as an energy source. In the hyperthermophilic archaeon Thermococcus onnurineus, which grows optimally at 80°C, CO oxidation and energy conservation is accomplished by a respiratory complex encoded by a 16-gene cluster containing a carbon monoxide dehydrogenase, a membrane-bound [NiFe]-hydrogenase and a Na+/H+ antiporter module. This complex oxidizes CO, evolves CO2 and H2, and generates a Na+ motive force that is used to conserve energy by a Na+-dependent ATP synthase. Herein we used a bacterial artificial chromosome to insert the 13.2 kb gene cluster encoding the CO-oxidizing respiratory complex of T. onnurineus into the genome of the heterotrophic archaeon, Pyrococcus furiosus, which grows optimally at 100°C. P. furiosus is normally unable to utilize CO, however, the recombinant strain readily oxidized CO and generated H2 at 80°C. Moreover, CO also served as an energy source and allowed the P. furiosus strain to grow with a limiting concentration of sugar or with peptides as the carbon source. Moreover, CO oxidation by P. furiosus was also coupled to the re-utilization, presumably for biosynthesis, of acetate generated by fermentation. The functional transfer of CO utilization between Thermococcus and Pyrococcus species demonstrated herein is representative of the horizontal gene transfer of an environmentally-relevant metabolic capability. The transfer of CO utilizing, hydrogen-producing genetic modules also has applications for biohydrogen production and a CO-based industrial platform for various thermophilic organisms.

  11. Direct evidence of 1,900 years of indigenous silver production in the Lake Titicaca Basin of Southern Peru.

    Science.gov (United States)

    Schultze, Carol A; Stanish, Charles; Scott, David A; Rehren, Thilo; Kuehner, Scott; Feathers, James K

    2009-10-13

    Archaeological excavations at a U-shaped pyramid in the northern Lake Titicaca Basin of Peru have documented a continuous 5-m-deep stratigraphic sequence of metalworking remains. The sequence begins in the first millennium AD and ends in the Spanish Colonial period ca. AD 1600. The earliest dates associated with silver production are 1960 + or - 40 BP (2-sigma cal. 40 BC to AD 120) and 1870 + or - 40 BP (2-sigma cal. AD 60 to 240) representing the oldest known silver smelting in South America. Scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS) analysis of production debris indicate a complex, multistage, high temperature technology for producing silver throughout the archaeological sequence. These data hold significant theoretical implications including the following: (i) silver production occurred before the development of the first southern Andean state of Tiwanaku, (ii) the location and process of silverworking remained consistent for 1,500 years even though political control of the area cycled between expansionist states and smaller chiefly polities, and (iii) that U-shaped structures were the location of ceremonial, residential, and industrial activities.

  12. Model-driven design of self-observing products

    NARCIS (Netherlands)

    Funk, M.

    2011-01-01

    Current complex electronic products are designed and developed by multi-disciplinary teams of stakeholders, and they are sold to customers world-wide who are often overwhelmed with the complexity of products. Product creation processes lack information about product usage and user experience in the

  13. Complex and rational use fish raw material at production of the fish products

    OpenAIRE

    Saltanova, N.; Saltanov, D.

    2011-01-01

    There was developed resource saving technology of herring preserves, which allows to rationally use raw, to cut lasting of the technological process, to lower the production costs and rise the economical effectiveness of production. There were defined the optimal conditions of getting broths of herring wastes. There were developed the recipes of fills at the base of broth from collagen-containing wastes of herring with the addition of vegetable raw.

  14. Strategic closed-loop facility location problem with carbon market trading

    DEFF Research Database (Denmark)

    Diabat, A.; Abdallah, T.; Al-Refaie, A.

    2013-01-01

    and recovery of products in a closed-loop configuration. Remanufacturing is the basis of profit-oriented reverse logistics in which recovered products are restored to a marketable condition in order to be resold to the primary or secondary market. In this paper, we introduce a multiechelon multicommodity...... facility location problem with a trading price of carbon emissions and a cost of procurement. The company might either incur costs if the carbon cap, normally assigned by regulatory agencies, is lower than the total emissions, or gain profit if the carbon cap is higher than the total emissions. A numerical...

  15. Managing complexity insights, concepts, applications

    CERN Document Server

    Helbing, Dirk

    2007-01-01

    Each chapter in Managing Complexity focuses on analyzing real-world complex systems and transferring knowledge from the complex-systems sciences to applications in business, industry and society. The interdisciplinary contributions range from markets and production through logistics, traffic control, and critical infrastructures, up to network design, information systems, social conflicts and building consensus. They serve to raise readers' awareness concerning the often counter-intuitive behavior of complex systems and to help them integrate insights gained in complexity research into everyday planning, decision making, strategic optimization, and policy. Intended for a broad readership, the contributions have been kept largely non-technical and address a general, scientifically literate audience involved in corporate, academic, and public institutions.

  16. A Study on Recommendation Systems in Location Based Social Networking

    Directory of Open Access Journals (Sweden)

    Ranganath Ashok Kumar

    2017-01-01

    Full Text Available Smart devices in the hands of people are revolutionizing the social lifestyle of one's self. Everyone across the world are using smart devices linked to their social networking activities one such activity is to share location data by uploading the tagged media content like photos, videos. The data is of surroundings, events attended/attending and travel experiences. Users share their experiences at a given location through localization techniques. Using such data from social networks an attempt is made to analyse tagged media content to acquire information on user context, individual’s interests, tastes, behaviours and derive meaningful relationships amongst them are referred to as Location Based Social Networks (LBSNs. The resulting information can be used to market a product and to improve business, as well recommend a travel and plan an itinerary. This paper presents a comprehensive survey of recommended systems for LBSNs covering the concepts of LBSNs, terminologies of LBSN and various recommendation systems.

  17. Multiclausal Utterances Aren't Just for Big Kids: A Framework for Analysis of Complex Syntax Production in Spoken Language of Preschool- and Early School-Age Children

    Science.gov (United States)

    Arndt, Karen Barako; Schuele, C. Melanie

    2013-01-01

    Complex syntax production emerges shortly after the emergence of two-word combinations in oral language and continues to develop through the school-age years. This article defines a framework for the analysis of complex syntax in the spontaneous language of preschool- and early school-age children. The purpose of this article is to provide…

  18. About peculiarities of hydrocarbons deposits location in the productive series of the Baku archipelago area

    International Nuclear Information System (INIS)

    Gasanov, V.T.

    2002-01-01

    Full text : In Azerbaijan domestic and foreign companies hold wide-scaled prospecting operations in the central and southern parts of the Baku Archipelago and also in the Kobystan. There are hydrocarbons deposits determined in the northern of the Baku Archipelago. Deposits location by phase condition of hydrocarbons mainly follows the general regularity determined on many oil and gas bearing areas, pass of oil deposits to oil-gas and gas-condensate ones in the direction of increase of layers occurrence depth. There is also a considerable influence of a tectonic factor on the area location of deposits observed, expressing in difference of deposits height on different tectonic blocks and also there is an influence of a lithological factor. Results of works conducted on drilling and wells testing are still not enough for judging about lack of oil and gas content.

  19. Residential Location, Job Location, and Wages: Theory and Empirics

    DEFF Research Database (Denmark)

    Vejlin, Rune Majlund

    -to-job transition without changing workplace location. However, workers making a job-to-job transition which makes the workplace location closer to the residence experiences a wage drop. Furthermore, low wage workers and workers with high transportation costs are more likely to make job-to-job transitions, but also......I develop a stylized partial on-the-job equilibrium search model which incorporate a spatial dimension. Workers reside on a circle and can move at a cost. Each point on the circle has a wage distribution. Implications about wages and job mobility are drawn from the model and tested on Danish...... matched employer-employee data. The model predictions hold true. I find that workers working farther away from their residence earn higher wages. When a worker is making a job-to-job transition where he changes workplace location he experiences a higher wage change than a worker making a job...

  20. Location-Allocation model for food industrial using fuzzy criteria: A case study of dairy industry

    Directory of Open Access Journals (Sweden)

    Zahra Esfandiyari

    2011-07-01

    Full Text Available A good facility layout plays an important role on increasing the profitability of a production unit. A good location needs to meet different criteria such as the distance between the plants and the places to reach raw materials, customers, etc. In this paper, we proposed a multi criteria decision making problem to locate a suitable dairy plant. We assume that all factors influencing the plant involves uncertainty and proposed fuzzy numbers to handle the uncertainty associated with all input parameters. We apply the method for a real-world case study of dairy production unit and analyze the results of our proposed model.