40 CFR 60.584 - Monitoring of operations and recordkeeping requirements.

Science.gov (United States)

2010-07-01

... Performance for Flexible Vinyl and Urethane Coating and Printing § 60.584 Monitoring of operations and... continuously measures and records the VOC concentration of the exhaust vent stream from the control device and... other processes. (2) During the performance test, the owner or operator shall determine and record the...

32 CFR 584.8 - Garnishment.

Science.gov (United States)

2010-07-01

... PATERNITY § 584.8 Garnishment. (a) General. (1) Pub. L. 93-647 (42 U.S.C. 659) permits garnishment... pay. (E) Academy officials pay (except personal money allowances). (F) Accrued leave payments (basic...

Challenges Regarding IP Core Functional Reliability

Science.gov (United States)

Berg, Melanie D.; LaBel, Kenneth A.

2017-01-01

For many years, intellectual property (IP) cores have been incorporated into field programmable gate array (FPGA) and application specific integrated circuit (ASIC) design flows. However, the usage of large complex IP cores were limited within products that required a high level of reliability. This is no longer the case. IP core insertion has become mainstream including their use in highly reliable products. Due to limited visibility and control, challenges exist when using IP cores and subsequently compromise product reliability. We discuss challenges and suggest potential solutions to critical application IP insertion.

A 39-kD plasma membrane protein (IP39) is an anchor for the unusual membrane skeleton of Euglena gracilis

International Nuclear Information System (INIS)

Rosiere, T.K.; Marrs, J.A.; Bouck, G.B.

1990-01-01

The major integral plasma membrane protein (IP39) of Euglena gracilis was radiolabeled, peptide mapped, and dissected with proteases to identify cytoplasmic domains that bind and anchor proteins of the cell surface. When plasma membranes were radioiodinated and extracted with octyl glucoside, 98% of the extracted label was found in IP39 or the 68- and 110-kD oligomers of IP39. The octyl glucoside extracts were incubated with unlabeled cell surface proteins immobilized on nitrocellulose (overlays). Radiolabel from the membrane extract bound one (80 kD) of the two (80 and 86 kD) major membrane skeletal protein bands. Resolubilization of the bound label yielded a radiolabeled polypeptide identical in Mr to IP39. Intact plasma membranes were also digested with papain before or after radioiodination, thereby producing a cytoplasmically truncated IP39. The octyl glucoside extract of truncated IP39 no longer bound to the 80-kD membrane skeletal protein in the nitrocellulose overlays. EM of intact or trypsin digested plasma membranes incubated with membrane skeletal proteins under stringent conditions similar to those used in the nitrocellulose overlays revealed a partially reformed membrane skeletal layer. Little evidence of a membrane skeletal layer was found, however, when plasma membranes were predigested with papain before reassociation. A candidate 80-kD binding domain of IP39 has been tentatively identified as a peptide fragment that was present after trypsin digestion of plasma membranes, but was absent after papain digestion in two-dimensional peptide maps of IP39. Together, these data suggest that the unique peripheral membrane skeleton of Euglena binds to the plasma membrane through noncovalent interactions between the major 80-kD membrane skeletal protein and a small, papain sensitive cytoplasmic domain of IP39

Development of a type IP-2 freight container and leak testing during the longitudinal and transverse racking tests

International Nuclear Information System (INIS)

Holden, G.V.

2002-01-01

The leak performance of freight containers has never been particularly well defined within the UK and up to the publication of 'A DETR guide to the approval of freight containers as IP-2 and IP-3 packages' freight containers with twin rear doors were acceptable as IP-2/3 packages. The containment argument has usually been based on providing adequate load securing and transport under exclusive use (with no transhipment between modes). Hence the likelihood for dropping the freight container during transhipment is eliminated. These arguments are less acceptable to competent authorities and the document above requires that leak integrity is determined during the standard freight container tests. This paper outlines the methodology used to determine the acceptable leak rate from the container (in terms of a pressure drop); the justification for conducting leak testing during racking only; the results of tests and difficulties that were overcome during design. (author)

VoIP Accessibility: A Usability Study of Voice over Internet Protocol (VoIP) Systems and A Survey of VoIP Users with Vision Loss

Science.gov (United States)

Packer, Jaclyn; Reuschel, William

2018-01-01

Introduction: Accessibility of Voice over Internet Protocol (VoIP) systems was tested with a hands-on usability study and an online survey of VoIP users who are visually impaired. The survey examined the importance of common VoIP features, and both methods assessed difficulty in using those features. Methods: The usability test included four paid…

Electrical production testing of the D0 Silicon microstrip tracker detector modules

Energy Technology Data Exchange (ETDEWEB)

D0, SMT Production Testing Group; /Fermilab

2006-03-01

The D0 Silicon Microstrip Tracker (SMT) is the innermost system of the D0 detector in Run 2. It consists of 912 detector units, corresponding to 5 different types of assemblies, which add up to a system with 792,576 readout channels. The task entrusted to the Production Testing group was to thoroughly debug, test and grade each detector module before its installation in the tracker. This note describes the production testing sequence and the procedures by which the detector modules were electrically tested and characterized at the various stages of their assembly.

Outbreak of Ips nitidus and Ips shangrila in northeastern margin of the Tibetan Plateau

Czech Academy of Sciences Publication Activity Database

Jakuš, R.; Kalinová, Blanka; Hoskovec, Michal; Knížek, M.; Schlyter, F.; Sun, J.-H.; Zhang, Q. H.

2011-01-01

Roč. 89, - (2011), s. 111-117 ISSN 1436-1566 R&D Projects: GA MŠk ME 860 Institutional research plan: CEZ:AV0Z40550506 Keywords : Ips shangrila * Ips nitidus * pheromone s * GCxGC-TOFMS Subject RIV: CC - Organic Chemistry

Analysis of IP Valuation Product of LIPI IDP000040604 as Marketing Strategy for Promotion of Innovative and Inventive Activities

Directory of Open Access Journals (Sweden)

Syukri Yusuf Nasution

2017-06-01

Full Text Available Abstract. IP Valuation means the process of how to compare object patented (protected and its characteristics with the similar to gain a benefit. In this research, the product that value has been registered and certified for the patent in Indonesia with number IDP000040604. IP Valuation conducted to estimate the potential future economic benefit of this product. Qualitative and quantitative methods carry out to determine the value of IP. A qualitative method performed by in-depth analysis for Legal, Technology, Market and Finance indicators. A quantitative method conducted to determine the value of IP by using income approach with DCF method. From the qualitative analysis it shows that the product is in low risk and high opportunity quadrant, and from quantitative analysis, it shows that the NPV of the product is Rp.52.088.550,- with a royalty rate of 7% with estimated turnover about Rp.692.921.848,- for 10 years of useful economic life. Keywords: IP Valuation, future economic benefit, qualitative and quantitative methods, high opportunity, royalty rate

EPOS IP - Data, Data Products, Services and Software (DDSS Master Table)

Science.gov (United States)

Michalek, Jan; Atakan, Kuvvet

2017-04-01

The "European Plate Observing System - Implementation Phase" (EPOS IP, 2014-2019) project is about building a pan-European infrastructure for accessing solid Earth science data. This ambitious plan started in 2002 already with a Conception Phase and continued by an EPOS PP (Preparatory Phase, 2010-2014) where about 20 partners joined the project. The current EPOS IP project includes 47 partners plus 6 associate partners from 25 countries from all over Europe and several international organizations (ORFEUS, EMSC, EUREF). However, the community contributing to the EPOS integration plan is larger than the official partnership of EPOS IP project, because more countries are represented by the international organizations and because within each country there are several research institutions involved. The list of Data, Data Products, Services and Software (DDSS) provided by individual institutions, consortia or organizations which will become part of the EPOS system are currently collected in document called DDSS Master Table. There are 10 work packages (WP8-WP17) creating the Thematic Core Services (TCS) always grouped by a specific topic: Seismology, Near Fault Observatories, GNSS Data and Products, Volcano Observations, Satellite Data, Geomagnetic Observations, Anthropogenic Hazards, Geological Information and Modelling, Multi-scale laboratories and Geo-Energy Test Beds for Low Carbon Energy. Each of this group declared a list of DDSS elements which are about to be implemented. Currently there are about 455 DDSS elements in the DDSS Master Table. These DDSS elements are of different maturity and about 122 are declared by TCS groups to be ready for implementation which means that the data are well described with metadata, following the standards specific for their domain and, in the best case, with some services allowing their access already. The DDSS elements differ by its complexity as well. The DDSS Master Table serves as an overview of the DDSS elements and

Machinability of IPS Empress 2 framework ceramic.

Science.gov (United States)

Schmidt, C; Weigl, P

2000-01-01

Using ceramic materials for an automatic production of ceramic dentures by CAD/CAM is a challenge, because many technological, medical, and optical demands must be considered. The IPS Empress 2 framework ceramic meets most of them. This study shows the possibilities for machining this ceramic with economical parameters. The long life-time requirement for ceramic dentures requires a ductile machined surface to avoid the well-known subsurface damages of brittle materials caused by machining. Slow and rapid damage propagation begins at break outs and cracks, and limits life-time significantly. Therefore, ductile machined surfaces are an important demand for machine dental ceramics. The machining tests were performed with various parameters such as tool grain size and feed speed. Denture ceramics were machined by jig grinding on a 5-axis CNC milling machine (Maho HGF 500) with a high-speed spindle up to 120,000 rpm. The results of the wear test indicate low tool wear. With one tool, you can machine eight occlusal surfaces including roughing and finishing. One occlusal surface takes about 60 min machining time. Recommended parameters for roughing are middle diamond grain size (D107), cutting speed v(c) = 4.7 m/s, feed speed v(ft) = 1000 mm/min, depth of cut a(e) = 0.06 mm, width of contact a(p) = 0.8 mm, and for finishing ultra fine diamond grain size (D46), cutting speed v(c) = 4.7 m/s, feed speed v(ft) = 100 mm/min, depth of cut a(e) = 0.02 mm, width of contact a(p) = 0.8 mm. The results of the machining tests give a reference for using IPS Empress(R) 2 framework ceramic in CAD/CAM systems. Copyright 2000 John Wiley & Sons, Inc.

Telefonía IP (ToIP): principios fundamentales, arquitectura y aspecto regulatorio en el Ecuador

OpenAIRE

Narváez García, William Fernando; Ugalde Peña, Pablo Esteban

2006-01-01

En este documento, hemos tratado de explicar el funcionamiento de la telefonía IP dentro de poco, comenzamos hablando con una introducción al tema al comentar sobre la actual tendencia a la conocida como patrón ALL-IP. Luego hemos visto conveniente hacer un comentario acerca de la evolución de las telecomunicaciones desde sus primeros pasos con Guillermo Marconi hasta nuestros días con la ToIP. De modo que existe un concepto claro de lo que la ToIP significa, en primer lugar se explica ...

Comparison of Integer Programming (IP) Solvers for Automated Test Assembly (ATA). Research Report. ETS RR-15-05

Science.gov (United States)

Donoghue, John R.

2015-01-01

At the heart of van der Linden's approach to automated test assembly (ATA) is a linear programming/integer programming (LP/IP) problem. A variety of IP solvers are available, ranging in cost from free to hundreds of thousands of dollars. In this paper, I compare several approaches to solving the underlying IP problem. These approaches range from…

12 CFR 584.2 - Prohibited activities.

Science.gov (United States)

2010-01-01

... Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY SAVINGS AND LOAN HOLDING COMPANIES § 584.2 Prohibited activities. (a) Evasion of law or regulation. No savings and loan holding... savings and loan holding company or subsidiary thereof that is not a savings association shall commence...

12 CFR 584.9 - Prohibited acts.

Science.gov (United States)

2010-01-01

... Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY SAVINGS AND LOAN HOLDING COMPANIES § 584.9 Prohibited acts. (a) Control of mutual savings association. No savings and loan holding company or any subsidiary thereof, or any director, officer, or employee of a savings and loan holding company or...

12 CFR 584.2-2 - Permissible bank holding company activities of savings and loan holding companies.

Science.gov (United States)

2010-01-01

... savings and loan holding companies. 584.2-2 Section 584.2-2 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY SAVINGS AND LOAN HOLDING COMPANIES § 584.2-2 Permissible bank holding company activities of savings and loan holding companies. (a) General. For purposes of § 584.2(b)(6)(i) of this part...

32 CFR 584.4 - Adoption proceedings.

Science.gov (United States)

2010-07-01

... CUSTODY, AND PATERNITY § 584.4 Adoption proceedings. (a) General. This chapter does not apply to those... soldier for leave to attend an adoption hearing on (date) has been granted. (ii) A request by the soldier for leave to attend an adoption hearing on (date), if made, would be approved. (iii) Due to military...

An Attacker-Defender Model for IP-Based Networks

National Research Council Canada - National Science Library

Barkley, Timothy R

2008-01-01

.... Because IP flows are defined essentially in terms of origin-destination (O-D) pairs, we represent IP traffic engineering as a multi-commodity flow problem in which each O-D pair is treated as a separate commodity...

1-800-CALL-H.E.P. -- Experiences on a voice-over-IP test bed

International Nuclear Information System (INIS)

Matthews, W.

2000-01-01

Highly interactive Internet applications such as Voice-over-IP are extremely sensitive to network performance. Even on high performance research networks, many cases will require the use of differentiated services to achieve high (toll) quality conversations. In this talk the authors will describe a test bed over the Energy Sciences network (ESnet) between Lawrence Berkeley National Laboratory (LBNL), Stanford Linear Accelerator Center (SLAC), Argonne National Laboratory (ANL) and Sandia National Laboratory (Sandia). In particular the characteristics of Voice-over-IP calls between LBNL and SLAC will be reviewed and the effect of low, moderate and high congestion on the link will be quantified. The use of Per Hop Behavior (PHB) in IP headers with Weighted Fair Queuing (WFQ) in routers and the benefit they provide will be explained. A model of flows and performance will be presented and new techniques to predict the quality of calls are under development and will be reviewed. Comparisons with telephone reliability will be discussed and the feasibility of wide spread deployment of VoIP in HEP will be considered

Reference: 584 [Arabidopsis Phenome Database[Archive

Lifescience Database Archive (English)

Full Text Available ing in Arabidopsis thaliana shoot and root stem cell organizers. 7137 811-4 17429400 2007 Apr Nature Hashimo...nda K et al. 2007 Apr. Nature 446(7137):811-4. Throughout the lifespan of a plant, which in some cases can l... 584 http://metadb.riken.jp/db/SciNetS_ria224i/cria224u4ria224u17429400i Sarkar Ana

ELRIS2D: A MATLAB Package for the 2D Inversion of DC Resistivity/IP Data

OpenAIRE

Akca Irfan

2016-01-01

ELRIS2D is an open source code written in MATLAB for the two-dimensional inversion of direct current resistivity (DCR) and time domain induced polarization (IP) data. The user interface of the program is designed for functionality and ease of use. All available settings of the program can be reached from the main window. The subsurface is discretized using a hybrid mesh generated by the combination of structured and unstructured meshes, which reduces the computational cost of the whole invers...

An Iterative Interplanetary Scintillation (IPS) Analysis Using Time-dependent 3-D MHD Models as Kernels

Science.gov (United States)

Jackson, B. V.; Yu, H. S.; Hick, P. P.; Buffington, A.; Odstrcil, D.; Kim, T. K.; Pogorelov, N. V.; Tokumaru, M.; Bisi, M. M.; Kim, J.; Yun, J.

2017-12-01

The University of California, San Diego has developed an iterative remote-sensing time-dependent three-dimensional (3-D) reconstruction technique which provides volumetric maps of density, velocity, and magnetic field. We have applied this technique in near real time for over 15 years with a kinematic model approximation to fit data from ground-based interplanetary scintillation (IPS) observations. Our modeling concept extends volumetric data from an inner boundary placed above the Alfvén surface out to the inner heliosphere. We now use this technique to drive 3-D MHD models at their inner boundary and generate output 3-D data files that are fit to remotely-sensed observations (in this case IPS observations), and iterated. These analyses are also iteratively fit to in-situ spacecraft measurements near Earth. To facilitate this process, we have developed a traceback from input 3-D MHD volumes to yield an updated boundary in density, temperature, and velocity, which also includes magnetic-field components. Here we will show examples of this analysis using the ENLIL 3D-MHD and the University of Alabama Multi-Scale Fluid-Kinetic Simulation Suite (MS-FLUKSS) heliospheric codes. These examples help refine poorly-known 3-D MHD variables (i.e., density, temperature), and parameters (gamma) by fitting heliospheric remotely-sensed data between the region near the solar surface and in-situ measurements near Earth.

Population dynamics of eight-toothed spruce bark beetle (Ips typographus L.) in the region of National Nature Reserve Praděd in 1998 - 2001

Czech Academy of Sciences Publication Activity Database

Plašil, P.; Cudlín, Pavel

2005-01-01

Roč. 51, č. 8 (2005), s. 359-370 ISSN 1212-4834 R&D Projects: GA MŠk(CZ) OK 389 Institutional research plan: CEZ:AV0Z6087904 Keywords : Ips typographus (L.), population dynamics, management of Ips typographus, NNR Praděd, regulated disintegration Subject RIV: GK - Forestry

3-D spectral Induced Polarization (IP) imaging: Non-invasive characterization of contaminant plumes. Annual progress report, September 15, 1996 - September 14, 1997

International Nuclear Information System (INIS)

Frye, K.M.; Lesmes, D.P.; Morgan, F.D.; Rodi, W.; Shi, W.; Sturrock, J.

1997-01-01

'The objective of this project is to develop the scientific basis for characterizing contaminant plumes in the earth''s subsurface using field measurements of induced polarization (IP) effects. The first-year accomplishments are (1) laboratory experiments on fluid-saturated sandstones quantifying the dependence of spectral IP responses on solution chemistry and rock micro-geometry; (2) library research on the current understanding of electromagnetic coupling effects on IP data acquired in the field: and (3) development of prototype forward modeling and inversion algorithms for interpreting IP data in terms of 3-D models of complex resistivity.'

IP Centrex

OpenAIRE

Massa Torrelles, Roger

2006-01-01

Este documento recoge el trabajo realizado para diseñar e implementar una centralita o PBX para Telefonía IP basada en VoIP (Voz sobre IP) mediante SIP. Proporcionando una alternativa a las actuales centralitas de telefonía, basadas en hardware, que son caras y poco escalables. Se detallan los conceptos VoIP, IP Centrex, se plantean diferentes esquemas para el diseño de IP Centrex y se presentan los detalles de la implementación de IP Centrex. Para la implementación de IP...

Conceptual Design for the In-Pile Test Section(IPS) Improvement

Energy Technology Data Exchange (ETDEWEB)

Lee, Jong Min; Shim, Bong Sik; Lee, Chung Young; Chi, Dae Young; Park, Su Ki; Ahn, Sung Ho; Kim, Young Ki; Lee, Kye Hong; Kim, Kwan Hyun

2009-01-15

Conceptual design on the IPS, instrumentation and 1/4' Tubing, test fuel supports, test fuel inspection station and inner assembly O-ring replacement was suggested for their improvement. There is a need Jacking bolt on the Top flange for the inner assembly disassemble from the outer assembly and the replacement about the top flange O-ring to metal gasket to secure pressure boundary. Mechanical sealing was suggested instead of brazing. Instrumentation and tubing route should be modified for the reduction of bending and protection from unexpected occasion. Concept on the test fuel inspection station under the consideration of canal dimension. Top flange Bolt handling tool, O-ring replacement platform and O-ring replacement tool was designed for the O-ring replacement at the inner assembly.

Identification of a major IP5 kinase in Cryptococcus neoformans confirms that PP-IP5/IP7, not IP6, is essential for virulence

OpenAIRE

Li, Cecilia; Lev, Sophie; Saiardi, Adolfo; Desmarini, Desmarini; Sorrell, Tania C.; Djordjevic, Julianne T.

2016-01-01

Fungal inositol polyphosphate (IP) kinases catalyse phosphorylation of IP3 to inositol pyrophosphate, PP-IP5/IP7, which is essential for virulence of Cryptococcus neoformans. Cryptococcal Kcs1 converts IP6 to PP-IP5/IP7, but the kinase converting IP5 to IP6 is unknown. Deletion of a putative IP5 kinase-encoding gene (IPK1) alone (ipk1?), and in combination with KCS1 (ipk1?kcs1?), profoundly reduced virulence in mice. However, deletion of KCS1 and IPK1 had a greater impact on virulence attenua...

Implementasi Sistem IP PBX menggunakan Briker

Directory of Open Access Journals (Sweden)

DWI ARYANTA

2017-06-01

used in order to make it easier for the Linux operating system to create a program which is using briker IP PBX that works on Linux 2.6 Operating System. After the installation process is done briker on Virtualbox IP PBX network implementation. After implementing the IP PBX network according to the topology, and then do a test call success rate and analysis of Quality of Service (QoS. Measurement of QoS parameters using jitter, delay, and packet loss resulting in the IP PBX system. Jitter value briker fellow users (either on a smartphone or computer has been on the average value of 16.77 ms. While the values ​​obtained packetloss when there is 1 user when a phone caller is 0%. While the percentage of packet loss at user 1 as a telephone receiver is 0.01%. Delay value when communicating between users located at 11.75 ms. Overall value obtained through this study , where the results of testing the QOS parameters in accordance with the standards recommended by the ITU and the QoS values ​​obtained with the results "good". Keywords : Briker, VoIP, QoS, IP PBX, Smartphone.

Numerical study on lateral wall displacement of deep excavation supported by IPS earth retention system

Directory of Open Access Journals (Sweden)

Tugen Feng

2017-12-01

Full Text Available The objective of this study is to investigate the 3D behavior characteristics of an excavation supported by an innovative prestressed support (IPS earth retention system. A numerical simulation was conducted in order to provide insight into the IPS system behavior by using the FLAC3D package. Prior to the parametric study, validation work was conducted by means of a comparison of the deformation between the field test data and numerical analysis results, and strong agreement was obtained. The reasonable excavation location, layered excavation thickness, and blocked excavation sequence are presented according to variable parameter analysis. In view of the previous findings, certain measurements are proposed in order to control the foundation pit deformation. The results indicate that prestress compensation has a significant effect on the IPS system behavior, while an optimized excavation sequence slightly improves its behavior. With the conclusion proposed based on the numerical results, the aim is to provide reference data for optimization design and the construction sequence. Keywords: FLAC3D, IPS system, Prestress compensation, Layered excavation, Blocked excavation, Deformation control

Effects of age on muscarinic agonist-induced contraction an IP accumulation in airway smooth muscle

International Nuclear Information System (INIS)

Wills-Karp, M.

1991-01-01

The effects of age on carbachol-stimulated force development and [ 3 H]inositol phosphate production was studied in tracheal rings from guinea pigs aged 1 month and 25 months of age. The pD 2 for the contractile response to carbachol was significantly reduced in tracheal tissues from old animals as compared to that of the young tissues, respectively. In contrast, inositol phosphate formation was not altered with increasing age when stimulated by carbachol or NaF, a direct activator of G proteins. Carbachol-induced inositol phosphate accumulation was inhibited by treatment with 1μg/ml pertussis toxin, suggesting that IP1 accumulation is coupled to a pertussis-toxin-sensitive protein. The pD 2 values for contraction were significantly different from the pD 2 values for IP1 accumulation, in both young and old tissues, respectively. These data suggest that IP1 accumulation is not responsible for the decreased contractile ability in tracheal smooth muscle during aging

Effects of age on muscarinic agonist-induced contraction an IP accumulation in airway smooth muscle

Energy Technology Data Exchange (ETDEWEB)

Wills-Karp, M. (Johns Hopkins Univ., Baltimore, MD (United States))

1991-01-01

The effects of age on carbachol-stimulated force development and ({sup 3}H)inositol phosphate production was studied in tracheal rings from guinea pigs aged 1 month and 25 months of age. The pD{sub 2} for the contractile response to carbachol was significantly reduced in tracheal tissues from old animals as compared to that of the young tissues, respectively. In contrast, inositol phosphate formation was not altered with increasing age when stimulated by carbachol or NaF, a direct activator of G proteins. Carbachol-induced inositol phosphate accumulation was inhibited by treatment with 1{mu}g/ml pertussis toxin, suggesting that IP1 accumulation is coupled to a pertussis-toxin-sensitive protein. The pD{sub 2} values for contraction were significantly different from the pD{sub 2} values for IP1 accumulation, in both young and old tissues, respectively. These data suggest that IP1 accumulation is not responsible for the decreased contractile ability in tracheal smooth muscle during aging.

Thermostability of IFN-γ and IP-10 release assays for latent infection with Mycobacterium tuberculosis

DEFF Research Database (Denmark)

Blauenfeldt, Thomas; Wagner, Dirk; Aabye, Martine Grosos

2016-01-01

accuracy of IP-10 release assay and IGRAs. RESULTS: We included 65 patients with confirmed pulmonary tuberculosis and 160 healthy controls from 6 European centres collaborating in the TBnet. In patients, IP-10 responses increased 1.07 (IQR 0.90-1.36) fold and IFN-γ responses decreased 0.88 (IQR 0......INTRODUCTION: Interferon-γ (IFN-γ) inducible protein 10kD (IP-10) and IFN-γ release assays (IGRAs) are immunodiagnostic tests aiming to identify the presence of specific cellular immune responses, interpreted as markers for latent infection with Mycobacterium tuberculosis. Incubation at higher...

12 CFR 584.1 - Registration, examination and reports.

Science.gov (United States)

2010-01-01

... Section 584.1 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY SAVINGS AND LOAN... loan holding company, each savings and loan holding company shall register with the OTS by filing a registration statement H-(b)10. (2) Filing of annual/current reports. Each registered savings and loan holding...

HPC Access Using KVM over IP

Science.gov (United States)

2007-06-08

Lightwave VDE /200 KVM-over-Fiber (Keyboard, Video and Mouse) devices installed throughout the TARDEC campus. Implementation of this system required...development effort through the pursuit of an Army-funded Phase-II Small Business Innovative Research (SBIR) effort with IP Video Systems (formerly known as...visualization capabilities of a DoD High- Performance Computing facility, many advanced features are necessary. TARDEC-HPC’s SBIR with IP Video Systems

Expression profiling of miR-96, miR-584 and miR-422a in colon ...

African Journals Online (AJOL)

Purpose: To determine the correlation between miRNAs; miR-96, miR-422a and miR584, and colon cancer, and also to test whether any of these miRNAs can act as non-invasive biomarkers in colon cancer. Methods: The tumor samples and the corresponding normal mucosa used in this study were collected from 60 ...

Diffractive charm and jet production at HERA

International Nuclear Information System (INIS)

Savin, Alexander A.

2003-01-01

A new high precision inclusive measurement of the diffractive production of D* ± (2010) mesons in deep inelastic scattering (DIS) in the kinematic region Q 2 >1.5 GeV 2 , 0.02 IP 2 2 , 165 2 , χ IP < 0.03 are presented. Diffractive parton densities extracted using a NLO DGLAP QCD fit are used for comparisons with diffractive DIS and PHP dijet and open charm cross sections at HERA and the Tevatron, thus testing the factorization properties of hard diffraction

Voice Over Internet Protocol (VoIP) in a Control Center Environment

Science.gov (United States)

Pirani, Joseph; Calvelage, Steven

2010-01-01

The technology of transmitting voice over data networks has been available for over 10 years. Mass market VoIP services for consumers to make and receive standard telephone calls over broadband Internet networks have grown in the last 5 years. While operational costs are less with VoIP implementations as opposed to time division multiplexing (TDM) based voice switches, is it still advantageous to convert a mission control center s voice system to this newer technology? Marshall Space Flight Center (MSFC) Huntsville Operations Support Center (HOSC) has converted its mission voice services to a commercial product that utilizes VoIP technology. Results from this testing, design, and installation have shown unique considerations that must be addressed before user operations. There are many factors to consider for a control center voice design. Technology advantages and disadvantages were investigated as they refer to cost. There were integration concerns which could lead to complex failure scenarios but simpler integration for the mission infrastructure. MSFC HOSC will benefit from this voice conversion with less product replacement cost, less operations cost and a more integrated mission services environment.

VoIP Security

OpenAIRE

Fontanini, Piero

2008-01-01

VOIP or Voice Over Internet Protocol is a common term for phone service over IP based networks. There are much information about VoIP and some of how VoIP can be secured. There is however no standard for VoIP and no general solution for VoIP Security. The security in VoIP systems today are often non existing or in best case weak and often based on proprietary solutions. This master thesis investigates threats to VoIP system and describes existing alternatives for securing Vo...

3-D reconstructions of the early-November 2004 CDAW geomagnetic storms: analysis of Ooty IPS speed and density data

Directory of Open Access Journals (Sweden)

M. M. Bisi

2009-12-01

Full Text Available Interplanetary scintillation (IPS remote-sensing observations provide a view of the solar wind covering a wide range of heliographic latitudes and heliocentric distances from the Sun between ~0.1 AU and 3.0 AU. Such observations are used to study the development of solar coronal transients and the solar wind while propagating out through interplanetary space. They can also be used to measure the inner-heliospheric response to the passage of coronal mass ejections (CMEs and co-rotating heliospheric structures. IPS observations can, in general, provide a speed estimate of the heliospheric material crossing the observing line of site; some radio antennas/arrays can also provide a radio scintillation level. We use a three-dimensional (3-D reconstruction technique which obtains perspective views from outward-flowing solar wind and co-rotating structure as observed from Earth by iteratively fitting a kinematic solar wind model to these data. Using this 3-D modelling technique, we are able to reconstruct the velocity and density of CMEs as they travel through interplanetary space. For the time-dependent model used here with IPS data taken from the Ootacamund (Ooty Radio Telescope (ORT in India, the digital resolution of the tomography is 10° by 10° in both latitude and longitude with a half-day time cadence. Typically however, the resolutions range from 10° to 20° in latitude and longitude, with a half- to one-day time cadence for IPS data dependant upon how much data are used as input to the tomography. We compare reconstructed structures during early-November 2004 with in-situ measurements from the Wind spacecraft orbiting the Sun-Earth L₁-Point to validate the 3-D tomographic reconstruction results and comment on how these improve upon prior reconstructions.

Securing VoIP keeping your VoIP network safe

CERN Document Server

(Bud) Bates, Regis J Jr

2015-01-01

Securing VoIP: Keeping Your VoIP Network Safe will show you how to take the initiative to prevent hackers from recording and exploiting your company's secrets. Drawing upon years of practical experience and using numerous examples and case studies, technology guru Bud Bates discusses the business realities that necessitate VoIP system security and the threats to VoIP over both wire and wireless networks. He also provides essential guidance on how to conduct system security audits and how to integrate your existing IT security plan with your VoIP system and security plans, helping you prevent

Status of RBCB testing of LMR oxide fuel in EBR-II

International Nuclear Information System (INIS)

Strain, R.V.; Bottcher, J.H.; Gross, K.C.; Lambert, J.D.B.; Ukai, S.; Nomura, S.; Shikakura, S.; Katsuragawa, M.

1991-01-01

The status is given of the the American-Japanese collaborative program in Experimental Breeder Reactor 2 to determine the run-beyond-cladding-breach performance of (UPu)O 2 fuel pins for liquid-metal cooled reactors. Phase 1 of the collaboration involved eighteen irradiation tests over 1981--86 with 5.84-mm pins in 316 or D9 stainless steel. Emphasis in Phase 2 tests from 1989 onwards is with larger diameter (7.5mm) pins in advanced claddings. Results include delayed neutron and fission gas release data from breached pins, the impact of fuel-sodium reaction product formation on pin performance, and fuel and fission product contamination from failures. 13 refs, 1 fig., 4 tabs

Antigen-Specific IP-10 Release Is a Sensitive Biomarker of Mycobacterium bovis Infection in Cattle.

Directory of Open Access Journals (Sweden)

Sven D C Parsons

Full Text Available The most widely used ante-mortem diagnostic tests for tuberculosis in cattle are the tuberculin skin test and the interferon-gamma (IFN-γ release assay, both of which measure cell-mediated immune responses to Mycobacterium bovis infection. However, limitations in the performance of these tests results in a failure to identify all infected animals. In attempting to increase the range of diagnostic tests for tuberculosis, measurement of the cytokine IP-10 in antigen-stimulated blood has previously been shown to improve the detection of M. tuberculosis and M. bovis infection, in humans and African buffaloes (Syncerus caffer, respectively. In the present study, 60 cattle were identified by the single intradermal comparative tuberculin test as tuberculosis reactors (n = 24 or non-reactors (n = 36 and the release of IFN-γ and IP-10 in antigen-stimulated whole blood from these animals was measured using bovine specific ELISAs. There was a strong correlation between IP-10 and IFN-γ production in these samples. Moreover, measurement of the differential release of IP-10 in response to stimulation with M. bovis purified protein derivative (PPD and M. avium PPD distinguished between reactor and non-reactor cattle with a sensitivity of 100% (95% CI, 86%-100% and a specificity of 97% (95% CI, 85%-100%. These results suggest that IP-10 might prove valuable as a diagnostic biomarker of M. bovis infection in cattle.

Impact of artefact removal on ChIP quality metrics in ChIP-seq and ChIP-exo data.

Directory of Open Access Journals (Sweden)

Thomas Samuel Carroll

2014-04-01

Full Text Available With the advent of ChIP-seq multiplexing technologies and the subsequent increase in ChIP-seq throughput, the development of working standards for the quality assessment of ChIP-seq studies has received significant attention. The ENCODE consortium’s large scale analysis of transcription factor binding and epigenetic marks as well as concordant work on ChIP-seq by other laboratories has established a new generation of ChIP-seq quality control measures. The use of these metrics alongside common processing steps has however not been evaluated. In this study, we investigate the effects of blacklisting and removal of duplicated reads on established metrics of ChIP-seq quality and show that the interpretation of these metrics is highly dependent on the ChIP-seq preprocessing steps applied. Further to this we perform the first investigation of the use of these metrics for ChIP-exo data and make recommendations for the adaptation of the NSC statistic to allow for the assessment of ChIP-exo efficiency.

Digital signage sobre IP

OpenAIRE

Casademont Filella, Albert

2012-01-01

Projecte que versa sobre el disseny i la implementació d'un sistema de Digital Signage (Cartelleria Digital) sobre IP, creant un gestor que permeti controlar de forma remota tot un conjunt de petits dispositius connectats a pantalles que emeten continguts multimèdia com vídeos, imatges, feeds rss...

Briefer assessment of social network drinking: A test of the Important People Instrument-5 (IP-5).

Science.gov (United States)

Hallgren, Kevin A; Barnett, Nancy P

2016-12-01

The Important People instrument (IP; Longabaugh et al., 2010) is one of the most commonly used measures of social network drinking. Although its reliability and validity are well-supported, the length of the instrument may limit its use in many settings. The present study evaluated whether a briefer, 5-person version of the IP (IP-5) adequately reproduces scores from the full IP. College freshmen (N = 1,053) reported their own past-month drinking, alcohol-related consequences, and information about drinking in their close social networks at baseline and 1 year later. From this we derived network members' drinking frequency, percentage of drinkers, and percentage of heavy drinkers, assessed for up to 10 (full IP) or 5 (IP-5) network members. We first modeled the expected concordance between full-IP scores and scores from simulated shorter IP instruments by sampling smaller subsets of network members from full IP data. Then, using quasi-experimental methods, we administered the full IP and IP-5 and compared the 2 instruments' score distributions and concurrent and year-lagged associations with participants' alcohol consumption and consequences. Most of the full-IP variance was reproduced from simulated shorter versions of the IP (ICCs ≥ 0.80). The full IP and IP-5 yielded similar score distributions, concurrent associations with drinking (r = 0.22 to 0.52), and year-lagged associations with drinking. The IP-5 retains most of the information about social network drinking from the full IP. The shorter instrument may be useful in clinical and research settings that require frequent measure administration, yielding greater temporal resolution for monitoring social network drinking. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

Real-time capture and reconstruction system with multiple GPUs for a 3D live scene by a generation from 4K IP images to 8K holograms.

Science.gov (United States)

Ichihashi, Yasuyuki; Oi, Ryutaro; Senoh, Takanori; Yamamoto, Kenji; Kurita, Taiichiro

2012-09-10

We developed a real-time capture and reconstruction system for three-dimensional (3D) live scenes. In previous research, we used integral photography (IP) to capture 3D images and then generated holograms from the IP images to implement a real-time reconstruction system. In this paper, we use a 4K (3,840 × 2,160) camera to capture IP images and 8K (7,680 × 4,320) liquid crystal display (LCD) panels for the reconstruction of holograms. We investigate two methods for enlarging the 4K images that were captured by integral photography to 8K images. One of the methods increases the number of pixels of each elemental image. The other increases the number of elemental images. In addition, we developed a personal computer (PC) cluster system with graphics processing units (GPUs) for the enlargement of IP images and the generation of holograms from the IP images using fast Fourier transform (FFT). We used the Compute Unified Device Architecture (CUDA) as the development environment for the GPUs. The Fast Fourier transform is performed using the CUFFT (CUDA FFT) library. As a result, we developed an integrated system for performing all processing from the capture to the reconstruction of 3D images by using these components and successfully used this system to reconstruct a 3D live scene at 12 frames per second.

Approche complète de développement des IPs pour les SoCs A ...

African Journals Online (AJOL)

CoFluent and Quartus II tools have helped us to get the different models. ... Key words : IPs – SoC - Design and Reuse – UML – System C ... nouvelles techniques de conception doivent- .... obtenir un prototype fabriqué et testé. ..... Information Technology and Control, ... A new logic circuit design methodology with UMLl.

Empirical assessment of VoIP overload detection tests

NARCIS (Netherlands)

Żuraniewski, P.; Mandjes, M.; Mellia, M.

2010-01-01

The control of communication networks critically relies on procedures capable of detecting unanticipated load changes. In this paper we explore such techniques, in a setting in which each connection consumes roughly the same amount of bandwidth (with VoIP as a leading example). We focus on

In-Pile Section(IPS) Inner Assembly Manufacturing Report

International Nuclear Information System (INIS)

Lee, Jong Min; Shim, Bong Sik; Lee, Chung Yong

2009-12-01

The objective of this report is to present the manufacturing, assembling and testing process of IPS Inner Assembly used in Fuel Test Loop(FTL) pre-operation test. The majority of the manufactured components are test fuels, inner assembly structures and subsidiary tools that is needed during the assembly process. In addition, Mock-up test for the welding and brazing is included at this stage. Lower structure, such as test fuels, fuel carrier legs are assembled and following structures, such as fuel carrier stem in the middle structure, top flange in the top structure are assembled together each other. To Verify the Reactor Coolant Pressure Boundary(RCPB) function in IPS Inner Assembly helium leak test and hydraulic test is performed with its acceptance criteria. According to the ASME III code Authorized Nuclear Inspector(ANI) is required during the hydraulic test. As-built measurement and insulation resistance test are performed to the structures and instrumentations after the test process. All requirements are satisfied and the IPS Inner Assembly was loaded in HANARO IR-1 hole in September 25, 2009

PENGARUH METODE PEMBELAJARAN DAN GAYA BELAJAR SISWA TERHADAP HASIL BELAJAR IPS DI SMP NEGERI DI KOTA YOGYAKARTA

Directory of Open Access Journals (Sweden)

Prihma Sinta Utami

2015-03-01

______________________________________________________________ THE EFFECT OF LEARNING METHOD AND LEARNING STYLE ON THE ACHIEVEMENT IN IPS OF THE STUDENTS OF JUNIOR HIGH SCHOOLS IN YOGYAKARTA Abstract This research aims to revealthe effect of: (1 teaching methods on IPS learning outcomes, (2 the influence of learning styles on IPS learning outcomes, (3 the methods and learning styles on IPS learning outcomes. This research was a quasi experiment using the 2x2 factorial design. This research was conducted at SMP Negeri 15 Yogyakarta. The sample was VII B, VII E, VII H, and VII J classes, which was established using the simple random sampling technique. The data collection used a test and questionnaire. The instrument validity was measured by using the product moment formula and its realiability was measured by using Cronbanch’s Alpha. The data normality was tested by using Kolmogorof-Smirnov and the homogeneity test was tested by using Levene Test. The hypothesis of this research was tested by using the two-way Anova technique at the significance level of 0,05. The result of this research shows that: (1 the achievement in IPS of the students taught using the Think Pair Share method is higher than that of those taught using the problem-based learning method; (2 the achievement of the students taught using the Think Pair Share method is higher than that of those taught using the problem-based learning method for group of visual learning style; (3 the achievement of the students taught using the Think Pair Share method is higher than that of those taught using the problem-based learning method for group of auditorial learning style; and (4 there is no interaction between teaching method and learning style in influencing students’ achievement in IPS subject matter. Keywords:methods, learning style, IPS subject outcomes

New test methods for BIPV. Results from IP performance

International Nuclear Information System (INIS)

Jol, J.C.; Van Kampen, B.J.M.; De Boer, B.J.; Reil, F.; Geyer, D.

2009-11-01

Within the Performance project new test procedures for PV building products and the building performance as a whole when PV is applied in buildings have been drafted. It has resulted in a first draft of new test procedures for PV building products and proposals for tests for novel BIPV technology like thin film. The test proposed are a module breakage test for BIPV products, a fire safety test for BIPV products and a dynamic load test for BIPV products. Furthermore first proposals of how flexible PV modules could be tested in an appropriate way to ensure long time quality and safety of these new products are presented.

Involvement of N-methyl-d-aspartate receptors in the antidepressant-like effect of 5-hydroxytryptamine 3 antagonists in mouse forced swimming test and tail suspension test.

Science.gov (United States)

Kordjazy, Nastaran; Haj-Mirzaian, Arya; Amiri, Shayan; Ostadhadi, Sattar; Amini-Khoei, Hossein; Dehpour, Ahmad Reza

2016-02-01

Recent evidence indicates that 5-hydroxytryptamine 3 (5-HT3) antagonists such as ondansetron and tropisetron exert positive behavioral effects in animal models of depression. Due to the ionotropic nature of 5-HT3 and N-methyl-d-aspartate (NMDA) receptors, plus their contribution to the pathophysiology of depression, we investigated the possible role of NMDA receptors in the antidepressant-like effect of 5-HT3 receptor antagonists in male mice. In order to evaluate the animals' behavior in response to different treatments, we performed open-field test (OFT), forced swimming test (FST), and tail-suspension test (TST), which are considered as valid tasks for measuring locomotor activity and depressive-like behaviors in mice. Our data revealed that intraperitoneal (i.p.) administration of tropisetron (5, 10, and 30mg/kg) and ondansetron (0.01, and 0.1μg/kg) significantly decreased the immobility time in FST and TST. Also, co-administration of subeffective doses of tropisetron (1mg/kg, i.p.) or ondansetron (0.001μg/kg, i.p.) with subeffective doses of NMDA receptor antagonists, ketamine (1mg/kg, i.p.), MK-801 (0.05mg/kg, i.p.) and magnesium sulfate (10mg/kg, i.p.) resulted in a reduced immobility time both in FST and TST. The subeffective dose of NMDA (NMDA receptor agonist, 75mg/kg, i.p.) abolished the effects of 5-HT3 antagonists in FST and TST, further supporting the presumed interaction between 5-HT3 and NMDA receptors. These treatments did not affect the locomotor behavior of animals in OFT. Finally, the results of our study suggest that the positive effects of 5-HT3 antagonists on the coping behavior of mice in FST and TST are at least partly mediated through NMDA receptors participation. Copyright © 2015 Elsevier Inc. All rights reserved.

The Worldwide Interplanetary Scintillation (IPS) Stations (WIPSS) Network October 2016 Observing Campaign: Initial WIPSS Data Analyses

Science.gov (United States)

Bisi, M. M.; Fallows, R. A.; Jackson, B. V.; Tokumaru, M.; Gonzalez-Esparza, A.; Morgan, J.; Chashei, I. V.; Mejia-Ambriz, J.; Tyul'bashev, S. A.; Manoharan, P. K.; De la Luz, V.; Aguilar-Rodriguez, E.; Yu, H. S.; Barnes, D.; Chang, O.; Odstrcil, D.; Fujiki, K.; Shishov, V.

2017-12-01

Interplanetary Scintillation (IPS) allows for the determination of velocity and a proxy for plasma density to be made throughout the corona and inner heliosphere. Where sufficient observations are undertaken, the results can be used as input to the University of California, San Diego (UCSD) three-dimensional (3-D) time-dependent tomography suite to allow for the full 3-D reconstruction of both velocity and density throughout the inner heliosphere. By combining IPS results from multiple observing locations around the planet, we can increase both the temporal and spatial coverage across the whole of the inner heliosphere and hence improve forecast capability. During October 2016, a unique opportunity arose whereby the European-based LOw Frequency ARray (LOFAR) radio telescope was used to make nearly four weeks of continuous observations of IPS as a heliospheric space-weather trial campaign. This was expanded into a global effort to include observations of IPS from the Murchison Widefield Array (MWA) in Western Australia and many more observations from various IPS-dedicated WIPSS Network systems. LOFAR is a next-generation low-frequency radio interferometer capable of observing in the radio frequency range 10-250 MHz, nominally with up to 80 MHz bandwidth at a time. MWA in Western Australia is capable of observing in the 80-300 MHz frequency range nominally using up to 32 MHz of bandwidth. IPS data from LOFAR, ISEE, the MEXican Array Radio Telescope (MEXART), and, where possible, other WIPSS Network systems (such as LPI-BSA and Ooty), will be used in this study and we will present some initial findings for these data sets. We also make a first attempt at the 3-D reconstruction of multiple pertinent WIPSS results in the UCSD tomography. We will also try to highlight some of the potential future tools that make LOFAR a very unique system to be able to test and validate a whole plethora of IPS analysis methods with the same set of IPS data.

Localitzador Gràfic de Direccions IP 'IpLocInspector'

OpenAIRE

Ordóñez Chapado, Miguel

2006-01-01

En aquest treball s'ha desenvolupat una aplicació capaç de localitzar adreces IP. En este trabajo se ha desarrollado una aplicación capaz de localizar direcciones IP. In this work an application was developed capable of locating IP addresses.

Direct reduction of N-acetoxy-PhIP by tea polyphenols: a possible mechanism for chemoprevention against PhIP-DNA adduct formation

International Nuclear Information System (INIS)

Lin Dongxin; Thompson, Patricia A.; Teitel, Candee; Chen Junshi; Kadlubar, Fred F.

2003-01-01

The chemopreventive effect of tea against 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-DNA adduct formation and its mechanism were studied. Rats were exposed to freshly prepared aqueous extracts of green tea (3% (w/v)) as the sole source of drinking water for 10 days prior to administration with a single dose of PhIP (10 mg/kg body weight) by oral gavage. PhIP-DNA adducts in the liver, colon, heart, and lung were measured using the 32 P-postlabelling technique. Rats pre-treated with tea and given PhIP 20 h before sacrifice had significantly reduced levels of PhIP-DNA adducts as compared with controls given PhIP alone. The possible mechanism of protective effect of tea on PhIP-DNA adduct formation was then examined in vitro. It was found that an aqueous extract of green and black tea, mixtures of green and black tea polyphenols, as well as purified polyphenols could strongly inhibit the DNA binding of N-acetoxy-PhIP, a putative ultimate carcinogen of PhIP formed in vivo via metabolic activation. Among these, epigallocatechin gallate was exceptionally potent. HPLC analyses of these incubation mixtures containing N-acetoxy-PhIP and the tea polyphenols each revealed the production of the parent amine, PhIP, indicating the involvement of a redox mechanism. In view of the presence of relatively high levels of tea polyphenols in rat and human plasma after ingestion of tea, this study suggests that direct reduction of the ultimate carcinogen N-acetoxy-PhIP by tea polyphenols is likely to be involved in the mechanism of chemoprotection of tea against this carcinogen

Spojení s dynamickou IP adresou

Czech Academy of Sciences Publication Activity Database

Papík, Martin; Hodboď, J.

2013-01-01

Roč. 47, č. 2 (2013), s. 60-61 ISSN 1211-0906 R&D Projects: GA ČR GA13-02149S Institutional support: RVO:67985556 Keywords : dynamical IP adress * dynamic DNS * web services Subject RIV: JC - Computer Hardware ; Software

Continuously Connected With Mobile IP

Science.gov (United States)

2002-01-01

Cisco Systems developed Cisco Mobile Networks, making IP devices mobile. With this innovation, a Cisco router and its connected IP devices can roam across network boundaries and connection types. Because a mobile user is able to keep the same IP address while roaming, a live IP connection can be maintained without interruption. Glenn Research Center jointly tested the technology with Cisco, and is working to use it on low-earth-orbiting research craft. With Cisco's Mobile Networks functionality now available in Cisco IOS Software release 12.2(4)T, the commercial advantages and benefits are numerous. The technology can be applied to public safety, military/homeland security, emergency management services, railroad and shipping systems, and the automotive industry. It will allow ambulances, police, firemen, and the U.S. Coast Guard to stay connected to their networks while on the move. In the wireless battlefield, the technology will provide rapid infrastructure deployment for U.S. national defense. Airline, train, and cruise passengers utilizing Cisco Mobile Networks can fly all around the world with a continuous Internet connection. Cisco IOS(R) Software is a registered trademark of Cisco Systems.

Pressurisation of IP-SOFC technology for second generation hybrid application

Energy Technology Data Exchange (ETDEWEB)

Jones, L.

2005-07-01

The Integrated Planar Solid Oxide Fuel Cell (IP-SOFC) technology developed by Rolls-Royce plc is a hybrid fuel cell technology considered highly suitable for the distributed power generation market. This report presents the results of a project to examine the technical viability of the IP-SOFC technology and some of the associated hybrid system component technologies under pressurised conditions and to investigate the validity of the predicted pressurisation phenomena. The work included: identification of critical material specifications, construction processes, control parameters, etc; the design and commissioning of two pressurised IP-SOFC test rigs at Rolls Royce in Derby; testing two multi-bundle strips at high temperature and atmospheric pressure; testing an active IP-SOFC bundle at high temperature and pressure; testing an experimental steam reforming unit at high temperature and pressure; testing a novel low pressure drop, off-gas combustor concept under atmospheric and pressurised conditions; design studies to identify key parameters affecting the successful integration and packaging of the fuel cell stack with certain associated hybrid components; and designing a hybrid system experimental verification rig. Significant progress was made in addressing the development challenges associated with the IP-SOFC of leakage, performance, durability, yield and geometry, the reaction rate of steam reforming and emissions from the off-gas combustor. Recommendations for future work are made.

Use of IFN-γ and IP-10 detection in the diagnosis of latent tuberculosis infection in patients with inflammatory rheumatic diseases.

Science.gov (United States)

Villar-Hernández, Raquel; Latorre, Irene; Mínguez, Sonia; Díaz, Jéssica; García-García, Esther; Muriel-Moreno, Beatriz; Lacoma, Alicia; Prat, Cristina; Olivé, Alex; Ruhwald, Morten; Mateo, Lourdes; Domínguez, José

2017-10-01

Biologic agents are used against rheumatic diseases, however, they increase the risk of developing severe infections and diseases such as tuberculosis. We aimed to determine the benefits of IP-10 detection to diagnose latent tuberculosis infection (LTBI) in patients with inflammatory rheumatic diseases on different immunosuppressive drug regimens, and compare these results with IFN-γ detection. We included 64 patients with inflammatory rheumatic diseases. We used QuantiFERON Gold In-Tube (QFN-G-IT) and T-SPOT.TB to detect IFN-γ production, and an in-house ELISA for IP-10 detection from the previous QFN-G-IT stimulated samples. We assessed the combined use of IFN-γ release assays (IGRAs) and IP-10 test, and analyzed the influence of immunotherapy on the tests performance. We obtained 34.9% positive results by T-SPOT.TB, 25.0% by QFN-G-IT and 31.3% by IP-10 test. The combined use of IGRAs and IP-10 detection increased significantly the amount of positive results (p  0.05). IP-10 and IFN-γ detection is comparable and their combined use could increase the number of positive results in the diagnosis of LTBI in rheumatic patients. The tested assays were not influenced by rheumatoid immunosuppressive therapy. Thus, IP-10 could be of use in the development of new and improved LTBI diagnostic tools. Copyright © 2017 The British Infection Association. Published by Elsevier Ltd. All rights reserved.

Production Test IP-601-D: Evaluation of crud-forming characteristics of KER loop coolant containing NH{sub 4}OH for pH control

Energy Technology Data Exchange (ETDEWEB)

Neidner, R.

1963-08-06

The objective of production test detailed in this report was to characterize the effects of NH{sub 4}OH as a pH control agent in a recirculating, high temperature and pressure water system having NPR characteristics. Of particular interest is the crud forming and decomposition characteristics of NH{sub 4}OH at potential NPR conditions.

Evaluation of IP Portfolios

DEFF Research Database (Denmark)

Søberg, Peder Veng

2009-01-01

As a result of an inquiry concerning how to evaluate IP (intellectual property) portfolios in order to enable the best possible use of IP resources within organizations, an IP evaluation approach primarily applicable for patents and utility models is developed. The developed approach is useful...... of the organization owning the IP....

IP-telefon säästab oluliselt sidekulusid / Kristjan Otsmann

Index Scriptorium Estoniae

Otsmann, Kristjan, 1971-

2005-01-01

Telekomifirma Norby Telecomi poolt pakutavast IP-telefonist ehk helistamisest läbi Interneti, millega saab vähendada sidekulusid mitmeid kordi. Erinevatest internetipõhise kõnesidelahenduse lisateenustest. Vt. samas: Saaremaa Spa Hotellid säästab tuhandeid kroone kuus [intervjuu Saaremaa Spa Hotellide IT-juhiga Andri Võrguga]; Kuus olulist tööd enne IP-lahenduse tellimist

EQuIP-ped for Success

Science.gov (United States)

Ewing, Molly

2015-01-01

The Educators Evaluating the Quality of Instructional Products (EQuIP) Rubric for science is a new tool for science educators that provides criteria by which to examine the alignment and overall quality of lessons and units with respect to the "Next Generation Science Standards" ("NGSS"). The rubric criteria are divided into…

PVM and IP multicast

Energy Technology Data Exchange (ETDEWEB)

Dunigan, T.H.; Hall, K.A.

1996-12-01

This report describes a 1994 demonstration implementation of PVM that uses IP multicast. PVM`s one-to-many unicast implementation of its pvm{_}mcast() function is replaced with reliable IP multicast. Performance of PVM using IP multicast over local and wide-area networks is measured and compared with the original unicast implementation. Current limitations of IP multicast are noted.

Mobile IP and protocol authentication extension

OpenAIRE

Nguyen, Phuc V.

2011-01-01

Mobile IP is an open standard, defined by the Internet Engineering Task Force (IETF) RFC 3220. By using Mobile IP, you can keep the same IP address, stay connected, and maintain ongoing applications while roaming between IP networks. Mobile IP is scalable for the Internet because it is based on IP - any media that can support IP can support Mobile IP.

An IP-10 (CXCL10)-Derived Peptide Inhibits Angiogenesis

Science.gov (United States)

Yates-Binder, Cecelia C.; Rodgers, Margaret; Jaynes, Jesse; Wells, Alan; Bodnar, Richard J.; Turner, Timothy

2012-01-01

Angiogenesis plays a critical role in processes such as organ development, wound healing, and tumor growth. It requires well-orchestrated integration of soluble and matrix factors and timely recognition of such signals to regulate this process. Previous work has shown that newly forming vessels express the chemokine receptor CXC receptor 3 (CXCR3) and, activation by its ligand IP-10 (CXCL10), both inhibits development of new vasculature and causes regression of newly formed vessels. To identify and develop new therapeutic agents to limit or reverse pathological angiogenesis, we identified a 21 amino acid fragment of IP-10, spanning the α-helical domain residues 77–98, that mimic the actions of the whole IP-10 molecule on endothelial cells. Treatment of the endothelial cells with the 22 amino acid fragment referred to as IP-10p significantly inhibited VEGF-induced endothelial motility and tube formation in vitro, properties critical for angiogenesis. Using a Matrigel plug assay in vivo, we demonstrate that IP-10p both prevented vessel formation and induced involution of nascent vessels. CXCR3 neutralizing antibody was able to block the inhibitory effects of the IP-10p, demonstrating specificity of the peptide. Inhibition of endothelial function by IP-10p was similar to that described for IP-10, secondary to CXCR3-mediated increase in cAMP production, activation of PKA inhibiting cell migration, and inhibition of VEGF-mediated m-calpain activation. IP-10p provides a novel therapeutic agent that inhibits endothelial cell function thus, allowing for the modulation of angiogenesis. PMID:22815829

Multiformat decoder for a DSP-based IP set-top box

Science.gov (United States)

Pescador, F.; Garrido, M. J.; Sanz, C.; Juárez, E.; Samper, D.; Antoniello, R.

2007-05-01

Internet Protocol Set-Top Boxes (IP STBs) based on single-processor architectures have been recently introduced in the market. In this paper, the implementation of an MPEG-4 SP/ASP video decoder for a multi-format IP STB based on a TMS320DM641 DSP is presented. An initial decoder for PC platform was fully tested and ported to the DSP. Using this code an optimization process was started achieving a 90% speedup. This process allows real-time MPEG-4 SP/ASP decoding. The MPEG-4 decoder has been integrated in an IP STB and tested in a real environment using DVD movies and TV channels with excellent results.

Impact of genome assembly status on ChIP-Seq and ChIP-PET data mapping

Directory of Open Access Journals (Sweden)

Sachs Laurent

2009-12-01

Full Text Available Abstract Background ChIP-Seq and ChIP-PET can potentially be used with any genome for genome wide profiling of protein-DNA interaction sites. Unfortunately, it is probable that most genome assemblies will never reach the quality of the human genome assembly. Therefore, it remains to be determined whether ChIP-Seq and ChIP-PET are practicable with genome sequences other than a few (e.g. human and mouse. Findings Here, we used in silico simulations to assess the impact of completeness or fragmentation of genome assemblies on ChIP-Seq and ChIP-PET data mapping. Conclusions Most currently published genome assemblies are suitable for mapping the short sequence tags produced by ChIP-Seq or ChIP-PET.

ejIP: A TCP/IP Stack for Embedded Java

DEFF Research Database (Denmark)

Schoeberl, Martin

2011-01-01

present the design and implementation of a network stack written entirely in Java. This implementation serves as an example how to implement system functions in a safe language and gives evidence that Java can be used for operating system related functionality. The described TCP/IP stack ejIP has already...

Performance Analysis of the Mobile IP Protocol (RFC 3344 and Related RFCS)

Science.gov (United States)

2006-12-01

field of 9 identifies the ICMP message as an adverstisement . Code Mobile IP home agents and foreign agents use the value of 16 to prevent any nodes...ANALYSIS OF THE MOBILE IP PROTOCOL (RFC 3344 AND RELATED RFCS) by Chin Chin Ng December 2006 Thesis Co-Advisors: George W. Dinolt J. D...December 2006 3. REPORT TYPE AND DATES COVERED Master’s Thesis 4. TITLE AND SUBTITLE Performance Analysis of the Mobile IP Protocol (RFC 3344 and

APLIKASI SERVER VIRTUAL IP UNTUK MIKROKONTROLER

OpenAIRE

Ashari, Ahmad

2008-01-01

Selama ini mikrokontroler yang terhubung ke satu komputer hanya dapat diakses melalui satu IP saja, padahal kebanyakan sistem operasi sekarang dapat memperjanjikan lebih dari satu IP untuk setiap komputer dalam bentuk virtual IP. Penelitian ini mengkaji pemanfaatan virtual IP dari IP aliasing pada sistem operasi Linux sebagai Server Virtual IP untuk mikrokontroler. Prinsip dasar Server Virtual IP adalah pembuatan Virtual Host pada masing-masing IP untuk memproses paket-paket data dan menerjem...

GluD1 is a common altered player in neuronal differentiation from both MECP2-mutated and CDKL5-mutated iPS cells.

Science.gov (United States)

Livide, Gabriella; Patriarchi, Tommaso; Amenduni, Mariangela; Amabile, Sonia; Yasui, Dag; Calcagno, Eleonora; Lo Rizzo, Caterina; De Falco, Giulia; Ulivieri, Cristina; Ariani, Francesca; Mari, Francesca; Mencarelli, Maria Antonietta; Hell, Johannes Wilhelm; Renieri, Alessandra; Meloni, Ilaria

2015-02-01

Rett syndrome is a monogenic disease due to de novo mutations in either MECP2 or CDKL5 genes. In spite of their involvement in the same disease, a functional interaction between the two genes has not been proven. MeCP2 is a transcriptional regulator; CDKL5 encodes for a kinase protein that might be involved in the regulation of gene expression. Therefore, we hypothesized that mutations affecting the two genes may lead to similar phenotypes by dysregulating the expression of common genes. To test this hypothesis we used induced pluripotent stem (iPS) cells derived from fibroblasts of one Rett patient with a MECP2 mutation (p.Arg306Cys) and two patients with mutations in CDKL5 (p.Gln347Ter and p.Thr288Ile). Expression profiling was performed in CDKL5-mutated cells and genes of interest were confirmed by real-time RT-PCR in both CDKL5- and MECP2-mutated cells. The only major change in gene expression common to MECP2- and CDKL5-mutated cells was for GRID1, encoding for glutamate D1 receptor (GluD1), a member of the δ-family of ionotropic glutamate receptors. GluD1 does not form AMPA or NMDA glutamate receptors. It acts like an adhesion molecule by linking the postsynaptic and presynaptic compartments, preferentially inducing the inhibitory presynaptic differentiation of cortical neurons. Our results demonstrate that GRID1 expression is downregulated in both MECP2- and CDKL5-mutated iPS cells and upregulated in neuronal precursors and mature neurons. These data provide novel insights into disease pathophysiology and identify possible new targets for therapeutic treatment of Rett syndrome.

IP3 stimulates CA++ efflux from fusogenic carrot protoplasts

International Nuclear Information System (INIS)

Rincon, M.; Boss, W.F.

1986-01-01

Polyphosphoinositide breakdown plays an important role in signal transduction in animal cells (Berridge and Irvine, 1984, Nature, 312:315). Upon stimulation, phospholipase C hydrolyzes phosphatidylinositol 4,5-bisphosphate to inositol 1,4,5-trisphosphate (IP 3 ) and diacylglycerol both of which act as cellular second messengers. IP 3 mobilizes Ca ++ from internal stores, hence the cytosolic free Ca ++ concentration increases and those physiological activities regulated by Ca ++ are stimulated. To test if plant cells also responded to IP 3 , Ca ++ efflux studies were done with fusogenic carrot protoplasts released in EGTA. The protoplasts were preloaded with 45 Ca ++ placed in a Ca ++ -free medium, and efflux determined as 45 Ca ++ loss from the protoplasts. IP 3 (10-20μM) caused enhanced 45 Ca ++ efflux and the response was sustained for at least 15 min. In plants, as in animals, the observed IP 3 -enhanced 45 Ca ++ efflux suggested that IP 3 released Ca ++ from internal stores, and the increased free cytosolic Ca ++ activated Ca ++ pumping mechanisms which restored the Ca ++ concentration in the cytosol to the normal level

The relation of innate and adaptive immunity with viral-induced acute asthma attacks: Focusing on IP-10 and cathelicidin.

Science.gov (United States)

Arikoglu, T; Akyilmaz, E; Yildirim, D D; Batmaz, S B; Ulger, S T; Aslan, G; Kuyucu, S

Despite growing evidence suggesting potential association between innate and adaptive immunity in viral-induced acute asthma, there is paucity of data in this area. This study aimed to investigate the association of innate and adaptive immunity with acute asthma attacks by analysing the role of IFN-γ-inducible protein 10 (IP-10), TLR2, cathelicidin, vitamin D and cytokines. This prospective study included 33 patients with viral-induced acute asthma and 30 children with controlled asthma. Nasopharyngeal swab samples were collected for virus identification and asthma attack scores assessed in acute asthma group. Blood sampling for IP-10, TLR2, cathelicidin, vitamin D levels, and spirometric indices were employed. Serum IP-10 and cathelicidin levels of acute asthma group were significantly higher and vitamin D levels were lower than controlled asthma group (IP-10; p=0.006, cathelicidin; p=0.002, vitamin D; pasthma attack severity (p=0.03) in acute asthma group. Higher cathelicidin values showed significant positive relation to IP-10 (beta coefficient: 33, p=0.02). Serum IP-10 levels higher than 38.9pg/ml (sensitivity: 85%, specificity: 47%, p=0.002) were predictive of virus-induced asthma. Serum IP-10 and vitamin D levels were found to be significantly related to viral-asthma attacks (IP-10; aOR: 8.93, p=0.03 and vitamin D; aOR: 0.82, p=0.001). Innate immunity biomarkers such as serum IP-10 and cathelicidin can be used to predict viral-induced acute asthma. These biomarkers may provide potential new treatment targets for acute asthma. Copyright © 2016 SEICAP. Published by Elsevier España, S.L.U. All rights reserved.

PARAGON-IPS: A Portable Imaging Software System For Multiple Generations Of Image Processing Hardware

Science.gov (United States)

Montelione, John

1989-07-01

Paragon-IPS is a comprehensive software system which is available on virtually all generations of image processing hardware. It is designed for an image processing department or a scientist and engineer who is doing image processing full-time. It is being used by leading R&D labs in government agencies and Fortune 500 companies. Applications include reconnaissance, non-destructive testing, remote sensing, medical imaging, etc.

Dynamic Optimization for IPS2 Resource Allocation Based on Improved Fuzzy Multiple Linear Regression

Directory of Open Access Journals (Sweden)

Maokuan Zheng

2017-01-01

Full Text Available The study mainly focuses on resource allocation optimization for industrial product-service systems (IPS2. The development of IPS2 leads to sustainable economy by introducing cooperative mechanisms apart from commodity transaction. The randomness and fluctuation of service requests from customers lead to the volatility of IPS2 resource utilization ratio. Three basic rules for resource allocation optimization are put forward to improve system operation efficiency and cut unnecessary costs. An approach based on fuzzy multiple linear regression (FMLR is developed, which integrates the strength and concision of multiple linear regression in data fitting and factor analysis and the merit of fuzzy theory in dealing with uncertain or vague problems, which helps reduce those costs caused by unnecessary resource transfer. The iteration mechanism is introduced in the FMLR algorithm to improve forecasting accuracy. A case study of human resource allocation optimization in construction machinery industry is implemented to test and verify the proposed model.

IP-I0 BASED IMMUNOLOGICAL MONITORING

DEFF Research Database (Denmark)

2008-01-01

The present invention relates to an immunological method and, more particularly, a method for measuring cell-mediated immune reactivity (CMI) in mammals based on the production of IP-10.The invention further discloses an assay and a kit for measuring CMI to an antigen using whole blood or other...

Comparing genome-wide chromatin profiles using ChIP-chip or ChIP-seq

NARCIS (Netherlands)

Johannes, Frank; Wardenaar, Rene; Colomé Tatché, Maria; Mousson, Florence; de Graaf, Petra; Mokry, Michal; Guryev, Victor; Timmers, H. Th. Marc; Cuppen, Edwin; Jansen, Ritsert C.; Bateman, Alex

2010-01-01

Motivation: ChIP-chip and ChIP-seq technologies provide genomewide measurements of various types of chromatin marks at an unprecedented resolution. With ChIP samples collected from different tissue types and/ or individuals, we can now begin to characterize stochastic or systematic changes in

Comparing genome-wide chromatin profiles using ChIP-chip or ChIP-seq

NARCIS (Netherlands)

Johannes, F.; Wardenaar, R.; Colome-Tatche, M.; Mousson, F.; de Graaf, P.; Mokry, M.; Guryev, V.; Timmers, H.T.; Cuppen, E.; Jansen, R.

2010-01-01

MOTIVATION: ChIP-chip and ChIP-seq technologies provide genome-wide measurements of various types of chromatin marks at an unprecedented resolution. With ChIP samples collected from different tissue types and/or individuals, we can now begin to characterize stochastic or systematic changes in

IP-10 release assays in the diagnosis of tuberculosis infection

DEFF Research Database (Denmark)

Ruhwald, Morten; Aabye, Martine G; Ravn, Pernille

2012-01-01

The current state-of-the-art tests for infection with Mycobacterium tuberculosis - the IFN-γ release assays - rely on accurate measurement of the cytokine IFN-γ. Many other potential biomarkers are expressed in concert with IFN-γ, and IP-10 in particular has shown promising results. IP-10...

SpaceWire: IP, Components, Development Support and Test Equipment

Science.gov (United States)

Parkes, S.; McClements, C.; Mills, S.; Martin, I.

SpaceWire is a communications network for use onboard spacecraft. It is designed to connect high data-rate sensors, large solid-state memories, processing units and the downlink telemetry subsystem providing an integrated data-handling network. SpaceWire links are serial, high-speed (2 Mbits/sec to 400 Mbits/sec), bi-directional, full-duplex, pointto- point data links which connect together SpaceWire equipment. Application information is sent along a SpaceWire link in discrete packets. Control and time information can also be sent along SpaceWire links. SpaceWire is defined in the ECSS-E50-12A standard [1]. With the adoption of SpaceWire on many space missions the ready availability of intellectual property (IP) cores, components, software drivers, development support, and test equipment becomes a major issue for those developing satellites and their electronic subsystems. This paper describes the work being done at the University of Dundee and STAR-Dundee Ltd with ESA, BNSC and internal funding to make these essential items available. STAR-Dundee is a spin-out company of the University of Dundee set up specifically to support users of SpaceWire.

Which IP Strategies Do Young Highly Innovative Firms Choose

DEFF Research Database (Denmark)

Veugelers, Reinhilde; Schneider, Cédric

2018-01-01

This paper describes and analyzes the strategies of young highly innovative companies to appropriate the returns from their innovations. Upon controlling for other firm and industry characteristics, we show that firms combining a young age and small scale with a high R&D intensive profile are mor...... likely to use intellectual property (IP), specifically combining formal and informal appropriation mechanisms. They are especially more likely to choose secrecy in combination with formal IP. This holds primarily when they introduce more radical innovations new to the market....

12 CFR 584.4 - Certain acquisitions by savings and loan holding companies.

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Certain acquisitions by savings and loan... TREASURY SAVINGS AND LOAN HOLDING COMPANIES § 584.4 Certain acquisitions by savings and loan holding companies. (a) Acquisitions by a savings and loan holding company of more than five percent of a non...

Ensuring Software IP Cleanliness

OpenAIRE

Mahshad Koohgoli; Richard Mayer

2007-01-01

At many points in the life of a software enterprise, determination of intellectual property (IP) cleanliness becomes critical. The value of an enterprise that develops and sells software may depend on how clean the software is from the IP perspective. This article examines various methods of ensuring software IP cleanliness and discusses some of the benefits and shortcomings of current solutions.

Gevaar VoIP voor telecomsector overdreven

NARCIS (Netherlands)

Deventer, M.O. van; Wegberg, M. van

2004-01-01

Het is een hype Voice-over-IP (VoIP) voor te stellen als een ontwrichtende technologie die de telecomindustrie ingrijpend zal veranderen. Maar hoe ontwrichtend is VoIP eigenlijk? Oskar van Deventer en Marc van Wegberg analyseren drie vormen van VoIP en laten zien dat alleen ‘VoIP-chat’ potentieel

Space Network IP Services (SNIS): An Architecture for Supporting Low Earth Orbiting IP Satellite Missions

Science.gov (United States)

Israel, David J.

2005-01-01

The NASA Space Network (SN) supports a variety of missions using the Tracking and Data Relay Satellite System (TDRSS), which includes ground stations in White Sands, New Mexico and Guam. A Space Network IP Services (SNIS) architecture is being developed to support future users with requirements for end-to-end Internet Protocol (IP) communications. This architecture will support all IP protocols, including Mobile IP, over TDRSS Single Access, Multiple Access, and Demand Access Radio Frequency (RF) links. This paper will describe this architecture and how it can enable Low Earth Orbiting IP satellite missions.

Ensuring Software IP Cleanliness

Directory of Open Access Journals (Sweden)

Mahshad Koohgoli

2007-12-01

Full Text Available At many points in the life of a software enterprise, determination of intellectual property (IP cleanliness becomes critical. The value of an enterprise that develops and sells software may depend on how clean the software is from the IP perspective. This article examines various methods of ensuring software IP cleanliness and discusses some of the benefits and shortcomings of current solutions.

Web-based IP telephony penetration system evaluating level of protection from attacks and threats

OpenAIRE

Vozňák, Miroslav; Řezáč, Filip

2011-01-01

This article deals with detection of threats in IP telephony, the authors developed a penetration testing system that is able to check up the level of protection from security threats in IP telephony. SIP is being widely used in building VoIP networks. Unlike the traditional telephone networks VoIP networks does not have a closed communication which makes communication medium vulnerable to all kinds of attacks from the in truders. The SIP server is a key component of VoIP infrastr...

Towards a Development Environment for Model Based Test Design

OpenAIRE

Jing, Han

2008-01-01

Within the UP IP I&V organization there is high focus on increasing the ability to predict product quality in a cost efficient way. Test automation has therefore been an important enabler for us. The IP test design environment is continuously evolving and the investigations will show which improvements that is most important to implement in short and long term. In Ericsson UP IP I&V, the test automation framework environments are severed to complete some process by automated method, f...

Implementasi Protokol Keamanan TLS pada Aplikasi Layanan Komunikasi Suara Melalui Jaringan TCP/IP (VoIP)

OpenAIRE

Hariady, Ricky

2011-01-01

Saat ini layanan komunikasi suara melalui jaringan TCP/IP atau yang lebih dikenal dengan VoIP (Voice over IP) telah semakin banyak digunakan, namun teknologi VoIP yang ada saat ini masih rentan terhadap penyadapan ataupun pencurian data. Sementara protokol kriptografi TLS (Transport Layer Security) telah teruji dan banyak digunakan untuk mengamankan komunikasi melalui internet seperti pada layanan email dan web. Dengan mengimplementasikan protokol TLS pada sebuah aplikasi Vo...

Foundations of hardware IP protection

CERN Document Server

Torres, Lionel

2017-01-01

This book provides a comprehensive and up-to-date guide to the design of security-hardened, hardware intellectual property (IP). Readers will learn how IP can be threatened, as well as protected, by using means such as hardware obfuscation/camouflaging, watermarking, fingerprinting (PUF), functional locking, remote activation, hidden transmission of data, hardware Trojan detection, protection against hardware Trojan, use of secure element, ultra-lightweight cryptography, and digital rights management. This book serves as a single-source reference to design space exploration of hardware security and IP protection. · Provides readers with a comprehensive overview of hardware intellectual property (IP) security, describing threat models and presenting means of protection, from integrated circuit layout to digital rights management of IP; · Enables readers to transpose techniques fundamental to digital rights management (DRM) to the realm of hardware IP security; · Introduce designers to the concept of salutar...

Future enhancements to 3D printing and real time production

Science.gov (United States)

Landa, Joseph; Jenkins, Jeffery; Wu, Jerry; Szu, Harold

2014-05-01

The cost and scope of additive printing machines range from several hundred to hundreds of thousands of dollars. For the extra money, one can get improvements in build size, selection of material properties, resolution, and consistency. However, temperature control during build and fusing predicts outcome and protects the IP by large high cost machines. Support material options determine geometries that can be accomplished which drives cost and complexity of printing heads. Historically, 3D printers have been used for design and prototyping efforts. Recent advances and cost reduction sparked new interest in developing printed products and consumables such as NASA who is printing food, printing consumer parts (e.g. cell phone cases, novelty toys), making tools and fixtures in manufacturing, and recursively print a self-similar printer (c.f. makerbot). There is a near term promise of the capability to print on demand products at the home or office... directly from the printer to use.

Ühisjooned sillutavad koostööd / Stephen Ip ; interv. Kristo Kiviorg

Index Scriptorium Estoniae

Ip, Stephen

2007-01-01

Ilmunud ka: Delovõje Vedomosti 20. juuni lk. 13. Hongkongi erihaldusregiooni majandus- ja tööhõiveminister Stephen Ip vastab küsimustele Eesti ja Hongkongi vahelise logistikakoostöö võimaluste kohta. Kommenteerib Elar Kilumets

A reassessment of the in vitro RBC haemolysis assay with defibrinated sheep blood for the determination of the ocular irritation potential of cosmetic products: comparison with the in vivo Draize rabbit test.

Science.gov (United States)

Alves, Eloísa Nunes; Presgrave, Rosaura de Farias; Presgrave, Octávio Augusto França; Sabagh, Fernanda Peres; de Freitas, João Carlos Borges Rolim; Corrado, Alexandre P

2008-07-01

We examined the correlation between results obtained from the in vivo Draize test for ocular irritation and in vitro results obtained from the sheep red blood cell (RBC) haemolytic assay, which assesses haemolysis and protein denaturation in erythrocytes, induced by cosmetic products. We sought to validate the haemolytic assay as a preliminary test for identifying highly-irritative products, and also to evaluate the in vitro test as alternative assay for replacement of the in vivo test. In vitro and in vivo analyses were carried out on 19 cosmetic products, in order to correlate the lesions in the ocular structures with three in vitro parameters: (i) the extent of haemolysis (H50); (ii) the protein denaturation index (DI); and (iii) the H50/DI ratio, which reflects the irritation potential (IP). There was significant correlation between maximum average scores (MAS) and the parameters determined in vitro (r = 0.752-0.764). These results indicate that the RBC assay is a useful and rapid test for use as a screening method to assess the IP of cosmetic products, and for predicting the IP value with a high level of concordance (94.7%). The assay showed high sensitivity and specificity rates of 91.6% and 100%, respectively.

Analisis Unjuk Kerja Aplikasi VoIP Call Android di Jaringan MANET [Performance Analysis of VoIP Call Application Android in MANET (Mobile Ad Hoc Network

Directory of Open Access Journals (Sweden)

Ryan Ari Setyawan

2015-06-01

Full Text Available Penelitian ini bertujuan menganalisis kinerja aplikasi  VoIP call android di jaringan MANET (mobile ad hoc network.  Hasil pengujian menunjukan bahwa aplikasi VoIP call android dapat digunakan di jaringan MANET. Delay yang dihasilkan paling besar di pengujian indoor dengan jarak 11-15 meter yakni sebesar 0,014624811 seconds. Packet loss yang dihasilkan pada range 1%-2% sedangkan standar packet loss yang ditetapkan oleh CISCO untuk layanan aplikasi VoIP adalah < 5%. Jitter yang dihasilkan yakni antara 0,01-0,06 seconds sedangkan standar yang ditetapkan oleh CISCO adalah ≤ 30 ms atau 0,03 seconds. Throughput yang dihasilkan pada proses pengujian yakni antar 161 kbps-481 kbps. *****This study aims to analyze the performance of VOIP call android application in the MANET (mobile ad hoc network. The results showed that VoIP applications could be implemented in MANET network. The highest  delay is produced in indoor testing  with distance of 11-15 meters,  which is equal to 0.014624811 seconds. Packet loss is generated in the range of 1% -2%, while packet loss standards set by Cisco for VoIP application services are <5%. The jitter is between 0.01 to 0.06 seconds, while the standard set by CISCO is ≤ 30 ms or 0.03 seconds. Throughput generated in the testing process is between 161 kbps-481 kbps.

Security Analysis System to Detect Threats on a SIP VoIP Infrasctructure Elements

Directory of Open Access Journals (Sweden)

Filip Rezac

2011-01-01

Full Text Available SIP PBX is definitely the alpha and omega of any IP telephony infrastructure and frequently also provides other services than those related to VoIP traffic. These exchanges are, however, very often the target of attacks by external actors. The article describes a system that was developed on VSB-TU Ostrava as a testing tool to verify if the target VoIP PBX is adequately secured and protected against any real threats. The system tests the SIP element for several usually occurring attacks and it compiles evaluation of its overall security on the basis of successfully or unsuccessfully penetrations. The article describes the applications and algorithms that are used by system and the conclusion consists recommendations and guidelines to ensure effective protection against VoIP PBX threats. The system is designed as an open-source web application, thus allowing independent access and is fully extensible to other test modules.

Structural safety test and analysis of type IP-2 transport packages with bolted lid type and thick steel plate for radioactive waste drums in a NPP

International Nuclear Information System (INIS)

Kim, Dong Hak; Seo, Ki Seog; Lee, Sang Jin; Lee, Kyung Ho; Kim, Jeong Mook

2007-01-01

If a type IP-2 transport package were to be subjected to a free drop test and a penetration test under the normal conditions of transport, it should prevent a loss or dispersal of the radioactive contents and a more than 20% increase in the maximum radiation level at any external surface of the package. In this paper, we suggested the analytic method to evaluate the structural safety of a type IP-2 transport package using a thick steel plate for a structure part and a bolt for tying a bolt. Using an analysis a loss or disposal of the radioactive contents and a loss of shielding integrity were confirmed for two kinds of type IP-2 transport packages to transport radioactive waste drums from a waste facility to a temporary storage site in a nuclear power plant. Under the free drop condition the maximum average stress at the bolts and the maximum opening displacement of a lid were compared with the tensile stress of a bolt and the steps in a lid, which were made to avoid a streaming radiation in the shielding path, to evaluate a loss or dispersal of radioactive waste contents. Also a loss of shielding integrity was evaluated using the maximum decrease in a shielding thickness. To verify the impact dynamic analysis for free drop test condition and evaluate experimentally the safety of two kinds of type IP-2 transport packages, free drop tests were conducted with various drop directions

Charged fusion product and fast ion loss in TFTR

International Nuclear Information System (INIS)

Zweben, S.J.; Darrow, D.S.; Fredrickson, E.D.; Mynick, H.E.; White, R.B.; Biglari, H.; Bretz, N.; Budny, R.; Bush, C.E.; Chang, C.S.; Chen, L.; Cheng, C.Z.; Fu, G.Y.; Hammett, G.W.; Hawryluk, R.J.; Hosea, J.; Johnson, L.; Mansfield, D.; McGuire, K.; Medley, S.S.; Nazikian, R.; Owens, D.K.; Park, H.; Park, J.; Phillips, C.K.; Schivell, J.; Stratton, B.C.; Ulrickson, M.; Wilson, R.; Young, K.M.; Fisher, R.; McChesney, J.; Fonck, R.; McKee, G.; Tuszewski, M.

1993-03-01

Several different fusion product and fast ion loss processes have been observed in TFTR using an array of pitch angle, energy and time resolved scintillator detectors located near the vessel wall. For D-D fusion products (3 MeV protons and 1 MeV tritons) the observed loss is generally consistent with expected first-orbit loss for Ip I MA. However, at higher currents, Ip = 1.4--2.5 MA, an NM induced D-D fusion product loss can be up to 3-4 times larger than the first-orbit loss, particularly at high beam powers, P ≥ 25 MW. The MHD induced loss of 100 KeV neutron beam ions and ∼0.5 MeV ICRF minority tail tons has also been measured ≤ 459 below the outer midplane. be potential implications of these results for D-T alpha particle experiments in TFTR and ITER are described

IPs

African Journals Online (AJOL)

Fr. Ikenga

special rights to the under-privileged IPs based on their culture, religion and .... and exploitation of natural resources, political determination and autonomy, .... supportive and sustaining.33Balancing individualism and communalism will avoid ...

Effectiveness of Cedar Oil Products for Preventing Host Use by Ips avulsus (Eichhoff) (Coleoptera: Curculionidae) in a Modified Small-Bolt Assay

Science.gov (United States)

B. L. Strom; L. M. Roton

2011-01-01

Insecticide products based on cedar oil are readily available, but evaluations against pine bark beetles (Coleoptera: Curculionidae: Scolytinae) are lacking. In the southeastern U.S., the southern pine beetle, Dendroctonus frontalis Zimm, is the major bark beetle pest for which tree protectants are applied. However, Ips avulsus (Eichhoff) are more consistently...

Offloading IP Flows onto Lambda-Connections

NARCIS (Netherlands)

Fioreze, Tiago; Oude Wolbers, Mattijs; van de Meent, R.; Pras, Aiko

2007-01-01

Optical networks are capable of switching IP traffic via lambda connections. In this way, big IP flows that overload the regular IP routing level may be moved to the optical level, where they get better Quality of Service (QoS). At the same time, the IP routing level is off-loaded and can serve

Mobile IP: Security & application

NARCIS (Netherlands)

Tuquerres, G.; Salvador, M.R.; Sprenkels, Ron

1999-01-01

As required in the TGS Mobile IP Advanced Module, this paper presents a survey of common security threats which mobile IP networks are exposed to as well as some proposed solutions to deal with such threats.

Voice over IP Security

CERN Document Server

Keromytis, Angelos D

2011-01-01

Voice over IP (VoIP) and Internet Multimedia Subsystem technologies (IMS) are rapidly being adopted by consumers, enterprises, governments and militaries. These technologies offer higher flexibility and more features than traditional telephony (PSTN) infrastructures, as well as the potential for lower cost through equipment consolidation and, for the consumer market, new business models. However, VoIP systems also represent a higher complexity in terms of architecture, protocols and implementation, with a corresponding increase in the potential for misuse. In this book, the authors examine the

Business innovation symposium ‘At what price? IP-related thoughts on new business models for space information’

Science.gov (United States)

Smith, Lesley Jane

2011-09-01

Spatial data and imagery generators are set to become tomorrow's key players in the information society. This is why satellite owners and operators are examining new revenue-producing models for developing space-related products and services. The use and availability of broadband internet width and satellite data-based services will continue to increase in the future. With the capacity to deliver real time precision downstream data, space agencies and the satellite industry can respond to the demand for high resolution digital space information which, with the appropriate technology, can be integrated into a variety of web-based applications. At a time when the traditional roles of space agencies are becoming more hybrid, largely as a result of the greater drive towards commercial markets, new value-added markets for space-related information products are continuing to attract attention. This paper discusses whether traditional data policies on space data access and IP licensing schemes stand to remain the feasible prototype for distributing and marketing space data, and how this growth market might benefit from looking at an 'up and running' global IP management system already operating to manage end user digital demand. PrefaceThe terminology describing the various types of spatial data and space-based information is not uniformly used within the various principles, laws and policies that govern space data. For convenience only this paper refers to primary or raw data gathered by the space-based industry as spatial or raw data, and the data as processed and sold on or distributed by ground-based companies as space information products and services. In practise, spatial data range from generic to specific data sets, digital topography, through to pictures and imagery services at various resolutions, with 3-D perspectives underway. The paper addresses general IP considerations relating to spatial data, with some reference to remote sensing itself. Exact IP details

IP Infrastructure Geolocation

Science.gov (United States)

2015-03-01

by non-commercial enti- ties. HostiP is a community-driven geolocation service. It provides an Application Pro- gramming Interface ( API ) for...NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS IP INFRASTRUCTURE GEOLOCATION Thesis Advisor: Second Reader: by Guan Yan Cai March...FUNDING NUMBERS IP INFRASTRUCfURE GEOLOCATION N66001-2250-59231 6. AUTHOR(S) Guan Yan Cai 7. PERFORMING ORGANIZATION NAME(S) AND AOORESS(ES) 9

GenoGAM: genome-wide generalized additive models for ChIP-Seq analysis.

Science.gov (United States)

Stricker, Georg; Engelhardt, Alexander; Schulz, Daniel; Schmid, Matthias; Tresch, Achim; Gagneur, Julien

2017-08-01

Chromatin immunoprecipitation followed by deep sequencing (ChIP-Seq) is a widely used approach to study protein-DNA interactions. Often, the quantities of interest are the differential occupancies relative to controls, between genetic backgrounds, treatments, or combinations thereof. Current methods for differential occupancy of ChIP-Seq data rely however on binning or sliding window techniques, for which the choice of the window and bin sizes are subjective. Here, we present GenoGAM (Genome-wide Generalized Additive Model), which brings the well-established and flexible generalized additive models framework to genomic applications using a data parallelism strategy. We model ChIP-Seq read count frequencies as products of smooth functions along chromosomes. Smoothing parameters are objectively estimated from the data by cross-validation, eliminating ad hoc binning and windowing needed by current approaches. GenoGAM provides base-level and region-level significance testing for full factorial designs. Application to a ChIP-Seq dataset in yeast showed increased sensitivity over existing differential occupancy methods while controlling for type I error rate. By analyzing a set of DNA methylation data and illustrating an extension to a peak caller, we further demonstrate the potential of GenoGAM as a generic statistical modeling tool for genome-wide assays. Software is available from Bioconductor: https://www.bioconductor.org/packages/release/bioc/html/GenoGAM.html . gagneur@in.tum.de. Supplementary information is available at Bioinformatics online. © The Author (2017). Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com

Determination of alpha particle detection efficiency of an imaging plate (IP) detector

International Nuclear Information System (INIS)

Rahman, N.M; Iida, Takao; Yamazawa, Hiromi; Moriizumi, Jun

2006-01-01

In order to determine the detection efficiency of the imaging plate (IP) detector, the true radioactivity of the alpha particles, which sampled in the collection media, should be known. The true radioactivity could be accurately predicted with the help of the reference alpha spectrometer measurement. The detection efficiency calculated for the IP was estimated with the theoretical curve and the experimental data. It is assumed that the air sample contained the decay products of both 222 Rn and 220 Rn series, the most significant sources of alpha particles. The present study estimated the detection efficiency of the IP as 39.3% with an uncertainty of 2.9 that is well enough to confirm the future use of the IP as a radiation detector. Experimental materials and methods are described. (S.Y.)

Short-term carcinogenicity testing of a potent murine intestinal mutagen, 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP), in Apc1638N transgenic mice

DEFF Research Database (Denmark)

Sørensen, Ilona Kryspin; Kristiansen, E.; Mortensen, Alicja

1997-01-01

others, mammary tumors, We have studied these mice in a short-term carcinogenicity test with 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine (PhIP), a potent murine small intestinal mutagen and lymphomagen. Upon dietary administration of 0.03% PhIP in a short-term (6 months) study, a significantly...

Mobile-ip Aeronautical Network Simulation Study

Science.gov (United States)

Ivancic, William D.; Tran, Diepchi T.

2001-01-01

NASA is interested in applying mobile Internet protocol (mobile-ip) technologies to its space and aeronautics programs. In particular, mobile-ip will play a major role in the Advanced Aeronautic Transportation Technology (AATT), the Weather Information Communication (WINCOMM), and the Small Aircraft Transportation System (SATS) aeronautics programs. This report presents the results of a simulation study of mobile-ip for an aeronautical network. The study was performed to determine the performance of the transmission control protocol (TCP) in a mobile-ip environment and to gain an understanding of how long delays, handoffs, and noisy channels affect mobile-ip performance.

Subtype-selective regulation of IP(3) receptors by thimerosal via cysteine residues within the IP(3)-binding core and suppressor domain.

Science.gov (United States)

Khan, Samir A; Rossi, Ana M; Riley, Andrew M; Potter, Barry V L; Taylor, Colin W

2013-04-15

IP(3)R (IP(3) [inositol 1,4,5-trisphosphate] receptors) and ryanodine receptors are the most widely expressed intracellular Ca(2+) channels and both are regulated by thiol reagents. In DT40 cells stably expressing single subtypes of mammalian IP(3)R, low concentrations of thimerosal (also known as thiomersal), which oxidizes thiols to form a thiomercurylethyl complex, increased the sensitivity of IP(3)-evoked Ca(2+) release via IP(3)R1 and IP(3)R2, but inhibited IP(3)R3. Activation of IP(3)R is initiated by IP(3) binding to the IBC (IP(3)-binding core; residues 224-604) and proceeds via re-arrangement of an interface between the IBC and SD (suppressor domain; residues 1-223). Thimerosal (100 μM) stimulated IP(3) binding to the isolated NT (N-terminal; residues 1-604) of IP(3)R1 and IP(3)R2, but not to that of IP(3)R3. Binding of a competitive antagonist (heparin) or partial agonist (dimeric-IP(3)) to NT1 was unaffected by thiomersal, suggesting that the effect of thimerosal is specifically related to IP(3)R activation. IP(3) binding to NT1 in which all cysteine residues were replaced by alanine was insensitive to thimerosal, so too were NT1 in which cysteine residues were replaced in either the SD or IBC. This demonstrates that thimerosal interacts directly with cysteine in both the SD and IBC. Chimaeric proteins in which the SD of the IP(3)R was replaced by the structurally related A domain of a ryanodine receptor were functional, but thimerosal inhibited both IP(3) binding to the chimaeric NT and IP(3)-evoked Ca(2+) release from the chimaeric IP(3)R. This is the first systematic analysis of the effects of a thiol reagent on each IP(3)R subtype. We conclude that thimerosal selectively sensitizes IP(3)R1 and IP(3)R2 to IP(3) by modifying cysteine residues within both the SD and IBC and thereby stabilizing an active conformation of the receptor.

Subtype-selective regulation of IP3 receptors by thimerosal via cysteine residues within the IP3-binding core and suppressor domain

Science.gov (United States)

Khan, Samir A.; Rossi, Ana M.; Riley, Andrew M.; Potter, Barry V. L.; Taylor, Colin W.

2013-01-01

IP3R (IP3 [inositol 1,4,5-trisphosphate] receptors) and ryanodine receptors are the most widely expressed intracellular Ca2+ channels and both are regulated by thiol reagents. In DT40 cells stably expressing single subtypes of mammalian IP3R, low concentrations of thimerosal (also known as thiomersal), which oxidizes thiols to form a thiomercurylethyl complex, increased the sensitivity of IP3-evoked Ca2+ release via IP3R1 and IP3R2, but inhibited IP3R3. Activation of IP3R is initiated by IP3 binding to the IBC (IP3-binding core; residues 224–604) and proceeds via re-arrangement of an interface between the IBC and SD (suppressor domain; residues 1–223). Thimerosal (100 μM) stimulated IP3 binding to the isolated NT (N-terminal; residues 1–604) of IP3R1 and IP3R2, but not to that of IP3R3. Binding of a competitive antagonist (heparin) or partial agonist (dimeric-IP3) to NT1 was unaffected by thiomersal, suggesting that the effect of thimerosal is specifically related to IP3R activation. IP3 binding to NT1 in which all cysteine residues were replaced by alanine was insensitive to thimerosal, so too were NT1 in which cysteine residues were replaced in either the SD or IBC. This demonstrates that thimerosal interacts directly with cysteine in both the SD and IBC. Chimaeric proteins in which the SD of the IP3R was replaced by the structurally related A domain of a ryanodine receptor were functional, but thimerosal inhibited both IP3 binding to the chimaeric NT and IP3-evoked Ca2+ release from the chimaeric IP3R. This is the first systematic analysis of the effects of a thiol reagent on each IP3R subtype. We conclude that thimerosal selectively sensitizes IP3R1 and IP3R2 to IP3 by modifying cysteine residues within both the SD and IBC and thereby stabilizing an active conformation of the receptor. PMID:23282150

Limitations and possibilities of low cell number ChIP-seq

Directory of Open Access Journals (Sweden)

Gilfillan Gregor D

2012-11-01

Full Text Available Abstract Background Chromatin immunoprecipitation coupled with high-throughput DNA sequencing (ChIP-seq offers high resolution, genome-wide analysis of DNA-protein interactions. However, current standard methods require abundant starting material in the range of 1–20 million cells per immunoprecipitation, and remain a bottleneck to the acquisition of biologically relevant epigenetic data. Using a ChIP-seq protocol optimised for low cell numbers (down to 100,000 cells / IP, we examined the performance of the ChIP-seq technique on a series of decreasing cell numbers. Results We present an enhanced native ChIP-seq method tailored to low cell numbers that represents a 200-fold reduction in input requirements over existing protocols. The protocol was tested over a range of starting cell numbers covering three orders of magnitude, enabling determination of the lower limit of the technique. At low input cell numbers, increased levels of unmapped and duplicate reads reduce the number of unique reads generated, and can drive up sequencing costs and affect sensitivity if ChIP is attempted from too few cells. Conclusions The optimised method presented here considerably reduces the input requirements for performing native ChIP-seq. It extends the applicability of the technique to isolated primary cells and rare cell populations (e.g. biobank samples, stem cells, and in many cases will alleviate the need for cell culture and any associated alteration of epigenetic marks. However, this study highlights a challenge inherent to ChIP-seq from low cell numbers: as cell input numbers fall, levels of unmapped sequence reads and PCR-generated duplicate reads rise. We discuss a number of solutions to overcome the effects of reducing cell number that may aid further improvements to ChIP performance.

IPS observation system for the Miyun 50 m radio telescope and its commissioning observation

International Nuclear Information System (INIS)

Zhu Xinying; Zhang Xizhen; Zhang Hongbo; Kong Deqing; Qu Huipeng

2012-01-01

Ground-based observation of Interplanetary Scintillation (IPS) is an important approach for monitoring solar wind. A ground-based IPS observation system has been newly implemented on a 50 m radio telescope at Miyun station, managed by the National Astronomical Observatories, Chinese Academy of Sciences. This observation system has been constructed for the purpose of observing solar wind speed and the associated scintillation index by using the normalized cross-spectrum of a simultaneous dual-frequency IPS measurement. The system consists of a universal dual-frequency front-end and a dual-channel multi-function back-end specially designed for IPS. After careful calibration and testing, IPS observations on source 3C 273B and 3C 279 have been successfully carried out. The preliminary observation results show that this newly-developed observation system is capable of performing IPS observation. The system's sensitivity for IPS observation can reach over 0.3 Jy in terms of an IPS polarization correlator with 4 MHz bandwidth and 2 s integration time. (research papers)

Applying a gaming approach to IP strategy.

Science.gov (United States)

Gasnier, Arnaud; Vandamme, Luc

2010-02-01

Adopting an appropriate IP strategy is an important but complex area, particularly in the pharmaceutical and biotechnology sectors, in which aspects such as regulatory submissions, high competitive activity, and public health and safety information requirements limit the amount of information that can be protected effectively through secrecy. As a result, and considering the existing time limits for patent protection, decisions on how to approach IP in these sectors must be made with knowledge of the options and consequences of IP positioning. Because of the specialized nature of IP, it is necessary to impart knowledge regarding the options and impact of IP to decision-makers, whether at the level of inventors, marketers or strategic business managers. This feature review provides some insight on IP strategy, with a focus on the use of a new 'gaming' approach for transferring the skills and understanding needed to make informed IP-related decisions; the game Patentopolis is discussed as an example of such an approach. Patentopolis involves interactive activities with IP-related business decisions, including the exploitation and enforcement of IP rights, and can be used to gain knowledge on the impact of adopting different IP strategies.

Vaccines and IP Rights: A Multifaceted Relationship.

Science.gov (United States)

Durell, Karen

2016-01-01

Just as there are many forms of vaccines and components to vaccines-particular compositions, delivery systems, components, and distribution networks-there are a variety of intellectual property (IP) protections applicable for vaccines. IP rights such as patent, copyright, trademarks, plant breeders' rights, and trade secrets may all be applicable to vaccines. Thus, discussion of IP rights and vaccines should not begin and end with the application of one IP right to a vaccine. The discussion should engage considerations of multiple IP rights applicable to a vaccine and how these can be utilized in an integrated manner in a strategy aimed at supporting the development and distribution of the vaccine. Such an approach to IP rights to vaccines allows for the integrated rights to be considered in light of the justifications for protecting vaccines with IP rights, as well as the issues relating to specific IP rights for vaccines, such as compulsory license regimes, available humanitarian purpose IP credits, etc. To view vaccines as the subject of multiple IP protections involves a refocusing, but the outcome can provide significant benefits for vaccine development and distribution.

A multicentre evaluation of the accuracy and performance of IP-10 for the diagnosis of infection with M. tuberculosis.

Science.gov (United States)

Ruhwald, Morten; Dominguez, Jose; Latorre, Irene; Losi, Monica; Richeldi, Luca; Pasticci, Maria Bruna; Mazzolla, Rosanna; Goletti, Delia; Butera, Ornella; Bruchfeld, Judith; Gaines, Hans; Gerogianni, Irini; Tuuminen, Tamara; Ferrara, Giovanni; Eugen-Olsen, Jesper; Ravn, Pernille

2011-05-01

IP-10 has potential as a diagnostic marker for infection with Mycobacterium tuberculosis, with comparable accuracy to QuantiFERON-TB Gold In-Tube test (QFT-IT). The aims were to assess the sensitivity and specificity of IP-10, and to evaluate the impact of co-morbidity on IP-10 and QFT-IT. 168 cases with active TB, 101 healthy controls and 175 non-TB patients were included. IP-10 and IFN-γ were measured in plasma of QFT-IT stimulated whole blood and analyzed using previously determined algorithms. A subgroup of 48 patients and 70 healthy controls was tested in parallel with T-SPOT.TB IP-10 and QFT-IT had comparable accuracy. Sensitivity was 81% and 84% with a specificity of 97% and 100%, respectively. Combining IP-10 and QFT-IT improved sensitivity to 87% (p IP-10. Among non-TB patients IP-10 had a higher rate of positive responders (35% vs 27%, p IP-10 responses to mitogen stimulation were reduced in patients with TB and non-TB infection. This study confirms and validates previous findings and adds substance to IP-10 as a novel diagnostic marker for infection with M. tuberculosis. IP-10 appeared less influenced by infections other than TB; further studies are needed to test the clinical impact of these findings. Copyright © 2011 Elsevier Ltd. All rights reserved.

Elevated IP-10 and IL-6 from bronchoalveolar lavage cells are biomarkers of non-cavitary tuberculosis.

Science.gov (United States)

Nolan, A; Condos, R; Huie, M L; Dawson, R; Dheda, K; Bateman, E; Rom, W N; Weiden, M D

2013-07-01

Active TB disease can destroy lung parenchyma leading to cavities. Immune responses that predispose or protect individuals from lung damage during TB are poorly defined. To sample lung immune cells and assay bronchoalveolar lavage (BAL) cell cytokine production. Enrolled subjects (n = 73) had bilateral infiltrates and underwent BAL. All had sputum culture demonstrating Mycobacterium tuberculosis and 22/73 (30%) had cavities on their chest radiograph. Those with cavities at presentation had a higher percentage of polymorphonuclear neutrophils (PMN) in BAL as well as lower inducible protein (IP) 10 (P IP-10 was negatively associated with BAL PMN. IP-10 and IL-6 expression above median reduces the odds of cavities by 79% and 78% in logistic regression models. IP-10 and IL-6 clustered with interferon-gamma and tumour necrosis factor-alpha in a principal component analysis, while IL-4 clustered with PMN. Increasing IP-10 and IL-6 production by BAL cells is associated with non-cavitary TB in patients who present with radiographically advanced TB. IP-10 and IL-6 may reflect an effective T-helper 1 immune control pathway for TB, attenuating tuberculous lung destruction.

Electric conductivity for laboratory and field monitoring of induced partial saturation (IPS) in sands

Science.gov (United States)

Kazemiroodsari, Hadi

Liquefaction is loss of shear strength in fully saturated loose sands caused by build-up of excess pore water pressure, during moderate to large earthquakes, leading to catastrophic failures of structures. Currently used liquefaction mitigation measures are often costly and cannot be applied at sites with existing structures. An innovative, practical, and cost effective liquefaction mitigation technique titled "Induced Partial Saturation" (IPS) was developed by researchers at Northeastern University. The IPS technique is based on injection of sodium percarbonate solution into fully saturated liquefaction susceptible sand. Sodium percarbonate dissolves in water and breaks down into sodium and carbonate ions and hydrogen peroxide which generates oxygen gas bubbles. Oxygen gas bubbles become trapped in sand pores and therefore decrease the degree of saturation of the sand, increase the compressibility of the soil, thus reduce its potential for liquefaction. The implementation of IPS required the development and validation of a monitoring and evaluation technique that would help ensure that the sands are indeed partially saturated. This dissertation focuses on this aspect of the IPS research. The monitoring system developed was based on using electric conductivity fundamentals and probes to detect the transport of chemical solution, calculate degree of saturation of sand, and determine the final zone of partial saturation created by IPS. To understand the fundamentals of electric conductivity, laboratory bench-top tests were conducted using electric conductivity probes and small specimens of Ottawa sand. Bench-top tests were used to study rate of generation of gas bubbles due to reaction of sodium percarbonate solution in sand, and to confirm a theory based on which degree of saturation were calculated. In addition to bench-top tests, electric conductivity probes were used in a relatively large sand specimen prepared in a specially manufactured glass tank. IPS was

Extending Tactical Fleet Communications Through VoIP

Science.gov (United States)

2014-09-01

corporate world , the military is leveraging VoIP communication solutions as well. Shore commands like Tactical Training Group Pacific use VoIP for...VoIP fuzzing (e.g., Asteroid , PROTOS, Sip-Proxy)  VoIP signaling manipulation (e.g., IAXAuthJack, IAXHangup, SIP-Kill)  VoIP media...as well, but instead of just matching the information to rules, it compares synchronization information between the protocols to determine if the

The hallucinogen d-lysergic acid diethylamide (d-LSD) induces the immediate-early gene c-Fos in rat forebrain.

Science.gov (United States)

Frankel, Paul S; Cunningham, Kathryn A

2002-12-27

The hallucinogen d-lysergic acid diethylamide (d-LSD) evokes dramatic somatic and psychological effects. In order to analyze the neural activation induced by this unique psychoactive drug, we tested the hypothesis that expression of the immediate-early gene product c-Fos is induced in specific regions of the rat forebrain by a relatively low, behaviorally active, dose of d-LSD (0.16 mg/kg, i.p.); c-Fos protein expression was assessed at 30 min, and 1, 2 and 4 h following d-LSD injection. A time- and region-dependent expression of c-Fos was observed with a significant increase (PLSD administration. These data demonstrate a unique pattern of c-Fos expression in the rat forebrain following a relatively low dose of d-LSD and suggest that activation of these forebrain regions contributes to the unique behavioral effects of d-LSD. Copyright 2002 Elsevier Science B.V.

Hardware IP security and trust

CERN Document Server

Bhunia, Swarup; Tehranipoor, Mark

2017-01-01

This book provides an overview of current Intellectual Property (IP) based System-on-Chip (SoC) design methodology and highlights how security of IP can be compromised at various stages in the overall SoC design-fabrication-deployment cycle. Readers will gain a comprehensive understanding of the security vulnerabilities of different types of IPs. This book would enable readers to overcome these vulnerabilities through an efficient combination of proactive countermeasures and design-for-security solutions, as well as a wide variety of IP security and trust assessment and validation techniques. This book serves as a single-source of reference for system designers and practitioners for designing secure, reliable and trustworthy SoCs.

Adjusting the IP $\\beta$ Functions in RHIC

CERN Document Server

Wittmer, W; Pilat, F; Ptitsyn, V; Van Zeijts, J

2004-01-01

The beta functions at the IP can be adjusted without perturbation of other optics functions via several approaches. In this paper we describe a scheme based on a vector knob, which assigns fixed values to the different tuning quadrupoles and scales them by a common multiplier. The values for the knob vector were calculated for a lattice without any errors using MADX. Previous studies for the LHC [1] have shown that this approach can meet the design goals. A specific feature of the RHIC lattice is the nested power supply system. To cope with the resulting problems a detailed response matrix analysis has been carried out and different sets of knobs were calculated and compared. The knobs were tested at RHIC during the 2004 run and preliminary results are discussed. Simultaneously a new approach to measure the beam sizes of both colliding beams at the IP, based on the tunability provided by the knobs, was developed and tested.

Presence in the IP multimedia subsystem

NARCIS (Netherlands)

Lin, L.; Liotta, A.

2007-01-01

With an ever increasing penetration of Internet Protocol (IP) technologies, the wireless industry is evolving the mobile core network towards all-IP network. The IP Multimedia Subsystem (IMS) is a standardised Next Generation Network (NGN) architectural framework defined by the 3rd Generation

A comparison of interferon-γ and IP-10 for the diagnosis of tuberculosis

DEFF Research Database (Denmark)

Holm, Line Lindebo; Rose, Michala Vaaben; Kimaro, Godfather

2014-01-01

OBJECTIVE: Interferon-γ and IP-10 release assays are diagnostic tests for tuberculosis infection. We have compared the accuracy of IP-10 and QuantiFERON-TB Gold In-tube [QFT-IT] in Tanzanian children suspected of having active tuberculosis (TB). METHODS: Hospitalized Tanzanian children...

Performance of VoIP on HSDPA

DEFF Research Database (Denmark)

Wang, Bang; Pedersen, Klaus I.; Kolding, Troels E.

2005-01-01

This paper provides packet scheduler design and performance simulations for running VoIP services over high-speed downlink packet access (HSDPA) in WCDMA. The main challenge of supporting VoIP service on HSDPA is the tight delay requirement combined with the small VoIP packet size. A packet...... scheduler design incorporating VoIP packet aggregation and user multiplexing is proposed and the VoIP capacity is studied for a macro-cellular environment. Results are obtained for different delay budgets and packet scheduling settings, using either blind round robin or a slightly modified version...... of proportional fair scheduling. For proportional fair scheduling with code-multiplexing of 4-users, the downlink VoIP cell capacity on HSDPA is found to be in the range 72-104 users depending on whether the delay budget for the Node-B scheduling and user reception equals 80 ms or 150 ms, respectively....

12 CFR 584.2a - Exempt savings and loan holding companies and grandfathered activities.

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Exempt savings and loan holding companies and... THE TREASURY SAVINGS AND LOAN HOLDING COMPANIES § 584.2a Exempt savings and loan holding companies and grandfathered activities. (a) Exempt savings and loan holding companies. (1) The following savings and loan...

The Spacelab IPS Star Simulator

Science.gov (United States)

Wessling, Francis C., III

The cost of doing business in space is very high. If errors occur while in orbit the costs grow and desired scientific data may be corrupted or even lost. The Spacelab Instrument Pointing System (IPS) Star Simulator is a unique test bed that allows star trackers to interface with simulated stars in a laboratory before going into orbit. This hardware-in-the loop testing of equipment on earth increases the probability of success while in space. The IPS Star Simulator provides three fields of view 2.55 x 2.55 degrees each for input into star trackers. The fields of view are produced on three separate monitors. Each monitor has 4096 x 4096 addressable points and can display 50 stars (pixels) maximum at a given time. The pixel refresh rate is 1000 Hz. The spectral output is approximately 550 nm. The available relative visual magnitude range is 2 to 8 visual magnitudes. The star size is less than 100 arc seconds. The minimum star movement is less than 5 arc seconds and the relative position accuracy is approximately 40 arc seconds. The purpose of this paper is to describe the LPS Star Simulator design and to provide an operational scenario so others may gain from the approach and possible use of the system.

The characteristics of Fugi IP Cassette Type PII and application for radiation oncology quality assurance tests and portal imaging

International Nuclear Information System (INIS)

Soh, H.S.; Ung, N.M.; Ng, K.H.

2008-01-01

Full text: The advancement of digital imaging has prompted more medical institutions to go filmless. The computed radiography (CR) system is becoming an important tool not only in diagnostic imaging, but also in radiation oncology. A new CR system that was specially designed for the use in radiation oncology. Fuji IP cassette type PII has been introduced to the market in the middle of year 2006. This project aimed to study some basic physical characteristics of this new type of cassette and explore its application for performing quality assurance (QA) tests and portal imaging in radiotherapy. All the images were read by FCR 5000 Plus reader. The image was found to reach its saturation value of 1023 (due to the image was stored in 10 bits data) by depending on the sensitivity value being adjusted. The uniformity test gave the result of 0.12%. The cassette was used to perform the QA tests which were previously performed using film. All the results met the specification as stated in AAPM Task Group 40. The comparison for the portal images of Portal Vision contrast-detail phantom showed that the spatial resolution of the images obtained by CR system (Fujifilm Co.. Ltd.. Tokyo. Japan) were better than the EPID (Varian Medical Systems. Inc.. Palo Alto. USA) and film system (Eastman Kodak Co.. New York. USA). The IP cassette type PII was found to be suitable as an alternative QA test tool and portal imaging in radiotherapy.

Measuring the impostor phenomenon: a comparison of Clance's IP Scale and Harvey's I-P Scale.

Science.gov (United States)

Holmes, S W; Kertay, L; Adamson, L B; Holland, C L; Clance, P R

1993-02-01

Many of the discrepancies reported to date in empirical investigations of the impostor phenomenon (IP) may be due in part to (a) the use of different methods for identifying individuals suffering from this syndrome (impostors), (b) the common use of a median split procedure to classify subjects and (c) the fact that subjects in many studies were drawn from impostor-prone samples. In this study, we compared the scores of independently identified impostors and nonimpostors on two instruments designed to measure the IP: Harvey's I-P Scale and Clance's IP Scale. The results suggest that Clance's scale may be the more sensitive and reliable instrument. Cutoff score suggestions for both instruments are offered.

A comparison of the microstructure and properties of the IPS Empress 2 and the IPS Empress glass-ceramics.

Science.gov (United States)

Höland, W; Schweiger, M; Frank, M; Rheinberger, V

2000-01-01

The aim of this report is to analyze the microstructures of glass-ceramics of the IPS Empress 2 and IPS Empress systems by scanning electron microscopy. The main properties of the glass-ceramics were determined and compared to each other. The flexural strength of the pressed glass-ceramic (core material) was improved by a factor of more than three for IPS Empress 2 (lithium disilicate glass-ceramic) in comparison with IPS Empress (leucite glass-ceramic). For the fracture toughness, the K(IC) value was measured as 3.3 +/- 0.3 MPa. m(0.5) for IPS Empress 2 and 1.3 +/- 0.1 MPa. m(0.5) for IPS Empress. Abrasion behavior, chemical durability, and optical properties such as translucency of all glass-ceramics fulfill the dental standards. The authors concluded that IPS Empress 2 can be used to fabricate 3-unit bridges up to the second premolar. Copyright 2000 John Wiley & Sons, Inc.

ChIP-PIT: Enhancing the Analysis of ChIP-Seq Data Using Convex-Relaxed Pair-Wise Interaction Tensor Decomposition.

Science.gov (United States)

Zhu, Lin; Guo, Wei-Li; Deng, Su-Ping; Huang, De-Shuang

2016-01-01

In recent years, thanks to the efforts of individual scientists and research consortiums, a huge amount of chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq) experimental data have been accumulated. Instead of investigating them independently, several recent studies have convincingly demonstrated that a wealth of scientific insights can be gained by integrative analysis of these ChIP-seq data. However, when used for the purpose of integrative analysis, a serious drawback of current ChIP-seq technique is that it is still expensive and time-consuming to generate ChIP-seq datasets of high standard. Most researchers are therefore unable to obtain complete ChIP-seq data for several TFs in a wide variety of cell lines, which considerably limits the understanding of transcriptional regulation pattern. In this paper, we propose a novel method called ChIP-PIT to overcome the aforementioned limitation. In ChIP-PIT, ChIP-seq data corresponding to a diverse collection of cell types, TFs and genes are fused together using the three-mode pair-wise interaction tensor (PIT) model, and the prediction of unperformed ChIP-seq experimental results is formulated as a tensor completion problem. Computationally, we propose efficient first-order method based on extensions of coordinate descent method to learn the optimal solution of ChIP-PIT, which makes it particularly suitable for the analysis of massive scale ChIP-seq data. Experimental evaluation the ENCODE data illustrate the usefulness of the proposed model.

Extraction Of Electronic Evidence From VoIP: Identification & Analysis Of Digital Speech

Directory of Open Access Journals (Sweden)

David Irwin

2012-09-01

Full Text Available The Voice over Internet Protocol (VoIP is increasing in popularity as a cost effective and efficient means of making telephone calls via the Internet. However, VoIP may also be an attractive method of communication to criminals as their true identity may be hidden and voice and video communications are encrypted as they are deployed across the Internet. This produces in a new set of challenges for forensic analysts compared with traditional wire-tapping of the Public Switched Telephone Network (PSTN infrastructure, which is not applicable to VoIP. Therefore, other methods of recovering electronic evidence from VoIP are required.  This research investigates the analysis and recovery of digitised human, which persists in computer memory after a VoIP call.This paper proposes a proof of concept how remnants of digitised human speech from a VoIP call may be identified within a forensic memory capture based on how the human voice is detected via a microphone and encoded to a digital format using the sound card of your personal computer. This digital format is unencrypted whist processed in Random Access Memory (RAM before it is passed to the VoIP application for encryption and  transmission over the Internet. Similarly, an incoming encrypted VoIP call is decrypted by the VoIP application and passes through RAM unencrypted in order to be played via the speaker output.A series of controlled tests were undertaken whereby RAM captures were analysed for remnants of digital speech after a VoIP audio call with known conversation. The identification and analysis of digital speech from RAM attempts to construct an automatic process for the identification and subsequent reconstruction of the audio content of a VoIP call.

An embedded offset and gain instrument for OpAmp IPs

NARCIS (Netherlands)

Wan, J.; Kerkhoff, Hans G.

2014-01-01

Analog and mixed-signal IPs are increasingly required to use digital fabrication technologies and are deeply embedded into system-on-chips (SoC). These developments append more requirements and challenges on analog testing methodologies. Traditional analog testing methods suffer from less

Voice over IP in Wireless Heterogeneous Networks

DEFF Research Database (Denmark)

Fathi, Hanane; Chakraborty, Shyam; Prasad, Ramjee

with the deployment of wireless heterogeneous systems, both speech and data traffic are carrried over wireless links by the same IP-based packet-switched infrastructure. However, this combination faces some challenges due to the inherent properties of the wireless network. The requirements for good quality VoIP...... communications are difficult to achieve in a time-varying environment due to channel errors and traffic congestion and across different systems. The provision of VoIP in wireless heterogeneous networks requires a set of time-efficient control mechanisms to support a VoIP session with acceptable quality....... The focus of Voice over IP in Wierless Heterogeneous Networks is on mechanisms that affect the VoIP user satisfaction  while not explicitly involved in the media session. This relates to the extra delays introduced by the security and the signaling protocols used to set up an authorized VoIP session...

Potassium Channel Interacting Protein 2 (KChIP2) is not a transcriptional regulator of cardiac electrical remodeling

DEFF Research Database (Denmark)

Winther, Sine V; Tuomainen, Tomi; Borup, Rehannah

2016-01-01

The heart-failure relevant Potassium Channel Interacting Protein 2 (KChIP2) augments CaV1.2 and KV4.3. KChIP3 represses CaV1.2 transcription in cardiomyocytes via interaction with regulatory DNA elements. Hence, we tested nuclear presence of KChIP2 and if KChIP2 translocates into the nucleus...... intracellular Ca(2+) concentration. Neither increasing nor decreasing intracellular Ca(2+) concentrations caused translocation of KChIP2. Microarray analysis did not identify relief of transcriptional repression in murine KChIP2(-/-) heart samples. We conclude that although there is a baseline presence of KCh...

Chromatin immunoprecipitation (ChIP) of plant transcription factors followed by sequencing (ChIP-SEQ) or hybridization to whole genome arrays (ChIP-CHIP)

NARCIS (Netherlands)

Kaufmann, K.; Muiño, J.M.; Østerås, M.; Farinelli, L.; Krajewski, P.; Angenent, G.C.

2010-01-01

Chromatin immunoprecipitation (ChIP) is a powerful technique to study interactions between transcription factors (TFs) and DNA in vivo. For genome-wide de novo discovery of TF-binding sites, the DNA that is obtained in ChIP experiments needs to be processed for sequence identification. The sequences

Generation of glucose-responsive functional islets with a three-dimensional structure from mouse fetal pancreatic cells and iPS cells in vitro.

Directory of Open Access Journals (Sweden)

Hiroki Saito

Full Text Available Islets of Langerhans are a pancreatic endocrine compartment consisting of insulin-producing β cells together with several other hormone-producing cells. While some insulin-producing cells or immature pancreatic cells have been generated in vitro from ES and iPS cells, islets with proper functions and a three-dimensional (3D structure have never been successfully produced. To test whether islets can be formed in vitro, we first examined the potential of mouse fetal pancreatic cells. We found that E16.5 pancreatic cells, just before forming islets, were able to develop cell aggregates consisting of β cells surrounded by glucagon-producing α cells, a structure similar to murine adult islets. Moreover, the transplantation of these cells improved blood glucose levels in hyperglycemic mice. These results indicate that functional islets are formed in vitro from fetal pancreatic cells at a specific developmental stage. By adopting these culture conditions to the differentiation of mouse iPS cells, we developed a two-step system to generate islets, i.e. immature pancreatic cells were first produced from iPS cells, and then transferred to culture conditions that allowed the formation of islets from fetal pancreatic cells. The islets exhibited distinct 3D structural features similar to adult pancreatic islets and secreted insulin in response to glucose concentrations. Transplantation of the islets improved blood glucose levels in hyperglycemic mice. In conclusion, the two-step culture system allows the generation of functional islets with a 3D structure from iPS cells.

Analisis Kualitas VoIP pada SCTP Menggunakan ECN dan AQM

Directory of Open Access Journals (Sweden)

La Surimi

2015-07-01

Abstract VoIP is the real time applications that are highly dependent on the quality of  delay and jitter, which it is difficult to be met by protocol that has reliable data transfer feature and  congestion control such as TCP. On the other hand the use of UDP that has no congestion control make chance of causing congestion in the network is very large. The use of SCTP as an alternative protocol was also not able to accommodate the weaknesses of TCP and UDP. Some research shows that repairs or modifications to the SCTP congestion control mechanism is needed. The Use of ECN and AQM in some studies show that these two mechanisms can reduce delay and jitter. This study tested the quality of VoIP over SCTP with ECN and AVQ, in NS2. Simulations carried out by independent replication technique, and the results showed that ECN and AVQ can increase the value of MOS VoIP calls significantly in non ideal network scenarios. This study also did comparison of SCTP MOS that uses ECN and AVQ with MOS values VoIP using TCP and UDP. The result showed that SCTP with ECN and AVQ outperform TCP but can not surpass UDP yet.   Keywords— VoIP, SCTP, ECN, AQM,AVQ.

Periodontal response to all-ceramic crowns (IPS Empress) in general practice.

Science.gov (United States)

Al-Wahadni, A M; Mansour, Y; Khader, Y

2006-02-01

The purpose of this study was to investigate the periodontal response to the presence of all-ceramic crowns (IPS Empress) in general practice patients. The convenience sample included 82 IPS Empress crowns placed in 64 patients. These crowns had been in place for an average of 16.27 (SD 9.26) months and ranged from 6.2 to 48.87 months at the time of clinical examination. Periodontal health status (as determined by dental plaque, gingival health status, periodontal pockets) was assessed around all crowned teeth and around matched contralateral teeth by one calibrated examiner. Periodontal indices utilized included the Plaque Index (PI), Gingival Index (GI) and pocket depth (PD) with calibrated probes graduated in millimetres. Plaque, gingival and PD values for crowned teeth were compared with those for control teeth using Wilcoxon signed-rank test for each clinical parameters. Chi-square was used to test the significance of the difference in their distribution between crowns and control teeth. Statistically, PI (0.35), GI (0.41) and mean PD scores (1.42) of IPS Empress crowned teeth compared less favourably with scores of the control teeth (0.27, 0.23 and 0.86 respectively). Teeth with IPS Empress crowns had poorer periodontal health and more clinically evident plaque than uncrowned teeth.

Pre-equilibrium Longitudinal Flow in the IP-Glasma Framework for Pb+Pb Collisions at the LHC

Science.gov (United States)

McDonald, Scott; Shen, Chun; Fillion-Gourdeau, François; Jeon, Sangyong; Gale, Charles

2017-08-01

In this work, we debut a new implementation of IP-Glasma and quantify the pre-equilibrium longitudinal flow in the IP-Glasma framework. The saturation physics based IP-Glasma model naturally provides a non-zero initial longitudinal flow through its pre-equilibrium Yang-Mills evolution. A hybrid IP-Glasma+MUSIC+UrQMD frame-work is employed to test this new implementation against experimental data and to make further predictions about hadronic flow observables in Pb+Pb collisions at 5.02 TeV. Finally, the non-zero pre-equilibrium longitudinal flow of the IP-Glasma model is quantified, and its origin is briefly discussed.

77 FR 33227 - Assessment Questionnaire-IP Sector Specific Agency Risk Self Assessment Tool (IP-SSARSAT)

Science.gov (United States)

2012-06-05

... DEPARTMENT OF HOMELAND SECURITY [Docket No. DHS-2011-0069] Assessment Questionnaire--IP Sector... comments concerning new Information Collection Request--Assessment Questionnaire--IP Sector Specific Agency... http://www.regulations.gov , including any personal information provided. OMB is particularly...

Inference of hierarchical regulatory network of estrogen-dependent breast cancer through ChIP-based data

Directory of Open Access Journals (Sweden)

Parvin Jeffrey

2010-12-01

Full Text Available Abstract Background Global profiling of in vivo protein-DNA interactions using ChIP-based technologies has evolved rapidly in recent years. Although many genome-wide studies have identified thousands of ERα binding sites and have revealed the associated transcription factor (TF partners, such as AP1, FOXA1 and CEBP, little is known about ERα associated hierarchical transcriptional regulatory networks. Results In this study, we applied computational approaches to analyze three public available ChIP-based datasets: ChIP-seq, ChIP-PET and ChIP-chip, and to investigate the hierarchical regulatory network for ERα and ERα partner TFs regulation in estrogen-dependent breast cancer MCF7 cells. 16 common TFs and two common new TF partners (RORA and PITX2 were found among ChIP-seq, ChIP-chip and ChIP-PET datasets. The regulatory networks were constructed by scanning the ChIP-peak region with TF specific position weight matrix (PWM. A permutation test was performed to test the reliability of each connection of the network. We then used DREM software to perform gene ontology function analysis on the common genes. We found that FOS, PITX2, RORA and FOXA1 were involved in the up-regulated genes. We also conducted the ERα and Pol-II ChIP-seq experiments in tamoxifen resistance MCF7 cells (denoted as MCF7-T in this study and compared the difference between MCF7 and MCF7-T cells. The result showed very little overlap between these two cells in terms of targeted genes (21.2% of common genes and targeted TFs (25% of common TFs. The significant dissimilarity may indicate totally different transcriptional regulatory mechanisms between these two cancer cells. Conclusions Our study uncovers new estrogen-mediated regulatory networks by mining three ChIP-based data in MCF7 cells and ChIP-seq data in MCF7-T cells. We compared the different ChIP-based technologies as well as different breast cancer cells. Our computational analytical approach may guide biologists to

Using cloud computing technologies in IP-video surveillance systems with the function of 3d-object modelling

Directory of Open Access Journals (Sweden)

Zhigalov Kirill

2018-01-01

Full Text Available This article is devoted to the integration of cloud technology functions into 3D IP video surveil-lance systems in order to conduct further video Analytics, incoming real-time data, as well as stored video materials on the server in the «cloud». The main attention is devoted to «cloud technologies» usage optimizing the process of recognition of the desired object by increasing the criteria of flexibility and scalability of the system. Transferring image load from the client to the cloud server, to the virtual part of the system. The development of the issues considered in the article in terms of data analysis, which will significantly improve the effectiveness of the implementation of special tasks facing special units.

IP3 production in the hypersensitive response of lemon seedlings against Alternaria alternata involves active protein tyrosine kinases but not a G-protein

Directory of Open Access Journals (Sweden)

XIMENA ORTEGA

2005-01-01

Full Text Available IP3 increase and de novo synthesis of scoparone are produced in the hypersensitive response (HR of lemon seedlings against the fungus Alternaria alternata. To elucidate whether a G-protein and/or a protein tyrosine kinase (PTK are involved in signal transduction leading to the production of such a defensive response, we studied the HR in this plant system after treatment with G-protein activators alone and PTK inhibitors in the presence of fungal conidia. No changes in the level of IP3 were detected in response to the treatment with the G-protein activators cholera toxin or mastoparan, although the HR was observed in response to these compounds as determined by the scoparone synthesis. On the contrary, the PTK inhibitors lavendustin A and 2,5-dihidroxy methyl cinnamate (DHMC not only prevented the IP3 changes observed in response to the fungal inoculation of lemon seedlings but also blocked the development of the HR. These results suggest that the IP3 changes observed in response to A. alternata require a PTK activity and are the result of a G-protein independent Phospholipase C activity, even though the activation of a G-protein can also lead to the development of a HR. Therefore, it appears that more than one signaling pathway may be activated for the development of HR in lemon seedlings: one involving a G-protein and the other involving a PTK-dependent PLC.

Structural performance of an IP2 package in free drop test conditions: Numerical and experimental evaluations

International Nuclear Information System (INIS)

Lo Frano, Rosa; Pugliese, Giovanni; Nasta, Marco

2014-01-01

Highlights: • Vertical free drop test. • Qualification of an IP2 type Italian packaging. • Numerical and experimental investigation of the package integrity. • Demonstration the Italian packaging meets safety requirements. - Abstract: The casks or packaging systems used for the transportation of nuclear materials, especially spent fuel elements, have to be designed according to rigorous acceptance requirements, like the IAEA ones, in order to provide protection to human beings and environment against radiation exposure and contamination. This study deals with the free drop test of an Italian design packaging system to be used for the transportation of low and intermediate level radioactive wastes. Impact drop experiments were performed in the Lab. Scalbatraio of the DICI – University of Pisa. Dynamic analyses too have been carried out, by refined models of both the cask and target surface to predict the effects of the impact shock (vertical drop) on the package. The experimental tests and numerical analyses are thoroughly compared, presented and discussed. The numerical approach shows to be suitable to reproduce with good reliability the test situations and results

Inositol hexakisphosphate (IP6) generated by IP5K mediates cullin-COP9 signalosome interactions and CRL function.

Science.gov (United States)

Scherer, Paul C; Ding, Yan; Liu, Zhiqing; Xu, Jing; Mao, Haibin; Barrow, James C; Wei, Ning; Zheng, Ning; Snyder, Solomon H; Rao, Feng

2016-03-29

The family of cullin-RING E3 Ligases (CRLs) and the constitutive photomorphogenesis 9 (COP9) signalosome (CSN) form dynamic complexes that mediate ubiquitylation of 20% of the proteome, yet regulation of their assembly/disassembly remains poorly understood. Inositol polyphosphates are highly conserved signaling molecules implicated in diverse cellular processes. We now report that inositol hexakisphosphate (IP6) is a major physiologic determinant of the CRL-CSN interface, which includes a hitherto unidentified electrostatic interaction between the N-terminal acidic tail of CSN subunit 2 (CSN2) and a conserved basic canyon on cullins. IP6, with an EC50 of 20 nM, acts as an intermolecular "glue," increasing cullin-CSN2 binding affinity by 30-fold, thereby promoting assembly of the inactive CRL-CSN complexes. The IP6 synthase, Ins(1,3,4,5,6)P5 2-kinase (IPPK/IP5K) binds to cullins. Depleting IP5K increases the percentage of neddylated, active Cul1 and Cul4A, and decreases levels of the Cul1/4A substrates p27 and p21. Besides dysregulating CRL-mediated cell proliferation and UV-induced apoptosis, IP5K depletion potentiates by 28-fold the cytotoxic effect of the neddylation inhibitor MLN4924. Thus, IP5K and IP6 are evolutionarily conserved components of the CRL-CSN system and are potential targets for cancer therapy in conjunction with MLN4924.

IP Security für Linux

OpenAIRE

Parthey, Mirko

2001-01-01

Die Nutzung des Internet für sicherheitskritische Anwendungen erfordert kryptographische Schutzmechanismen. IP Security (IPsec) definiert dafür geeignete Protokolle. Diese Arbeit gibt einen Überblick über IPsec. Eine IPsec-Implementierung für Linux (FreeS/WAN) wird auf Erweiterbarkeit und Praxistauglichkeit untersucht. Using the Internet in security-critical areas requires cryptographic protection, for which IP Security (IPsec) defines suitable protocols. This paper gives an overview of IP...

IP-10 measured by Dry Plasma Spots as biomarker for therapy responses in Mycobacterium Tuberculosis infection.

Science.gov (United States)

Tonby, Kristian; Ruhwald, Morten; Kvale, Dag; Dyrhol-Riise, Anne Ma

2015-03-18

Tuberculosis (TB) has huge impact on human morbidity and mortality and biomarkers to support rapid TB diagnosis and ensure treatment initiation and cure are needed, especially in regions with high prevalence of multi-drug resistant TB. Soluble interferon gamma inducible protein 10 (IP-10) analyzed from dry plasma spots (DPS) has potential as an immunodiagnostic marker in TB infection. We analyzed IP-10 levels in plasma directly and extracted from DPS in parallel by ELISA from 34 clinically well characterized patients with TB disease before and throughout 24 weeks of effective anti-TB chemotherapy. We detected a significant decline of IP-10 levels in both plasma and DPS already after two weeks of therapy with good correlation between the tests. This was observed both in pulmonary and extrapulmonary TB. In conclusion, plasma IP-10 may serve as an early biomarker for anti-TB chemotherapy responses and the IP-10 DPS method has potential to be developed into a point-of care test for use in resource-limited settings. Further studies must be performed to validate the use of IP-10 DPS in TB high endemic countries.

CMT: a constrained multi-level thresholding approach for ChIP-Seq data analysis.

Directory of Open Access Journals (Sweden)

Iman Rezaeian

Full Text Available Genome-wide profiling of DNA-binding proteins using ChIP-Seq has emerged as an alternative to ChIP-chip methods. ChIP-Seq technology offers many advantages over ChIP-chip arrays, including but not limited to less noise, higher resolution, and more coverage. Several algorithms have been developed to take advantage of these abilities and find enriched regions by analyzing ChIP-Seq data. However, the complexity of analyzing various patterns of ChIP-Seq signals still needs the development of new algorithms. Most current algorithms use various heuristics to detect regions accurately. However, despite how many formulations are available, it is still difficult to accurately determine individual peaks corresponding to each binding event. We developed Constrained Multi-level Thresholding (CMT, an algorithm used to detect enriched regions on ChIP-Seq data. CMT employs a constraint-based module that can target regions within a specific range. We show that CMT has higher accuracy in detecting enriched regions (peaks by objectively assessing its performance relative to other previously proposed peak finders. This is shown by testing three algorithms on the well-known FoxA1 Data set, four transcription factors (with a total of six antibodies for Drosophila melanogaster and the H3K4ac antibody dataset.

PEMBELAJARAN IPS DALAM REALITA DI ERA KTSP: STUDI EKSPLORASI PELAKSANAAN PEMBELAJARAN IPS PADA JENJANG SMP DI KABUPATEN PATI

Directory of Open Access Journals (Sweden)

Edi Sutrisna

2011-10-01

Full Text Available Application of KTSP as a curriculum based on competency requires the implementation of strategies and methods that can deliver a number of learners achieving a particular competence. IPS as a subject who has a noble purpose, namely to prepare students to be good citizens, should be taught to students through appropriate strategies and methods by utilizing various media sources and learning. Most social studies teachers still promote the use of expository strategies in presenting lessons of Social Science education and the use of resources and learning media are minimal. Environment, as a laboratory of IPS is not utilized properly.The study shows that most teachers still tend to use expository teaching strategies, use of resources and learning media that are less varied, and integrated approaches to teaching social studies can not be realized by the teachers due to various constraints.   Keywords: learning, IPS, junior school, KTSP   Penerapan KTSP sebagai kurikulum berbasis kompetensi membutuhkan penerapan strategi dan metode yang dapat memberikan sejumlah peserta didik mencapai kompetensi tertentu. IPS sebagai subjek yang memiliki tujuan mulia, yaitu untuk mempersiapkan siswa untuk menjadi warga negara yang baik, harus diajarkan kepada siswa melalui strategi yang tepat dan metode dengan memanfaatkan berbagai sumber media dan pembelajaran. Kebanyakan guru IPS masih menggunakan strategi ekspositori dalam menyajikan meteri pelajaran IPS dengan menggunakan sumber daya dan media pembelajaran yang minimal. Lingkungan sekitar, sebagai laboratorium IPS tidak digunakan menunjukkan pembelajaran yang baik. Kebanyakan guru masih cenderung untuk menggunakan strategi pengajaran ekspositori, penggunaan sumber daya dan media pembelajaran yang kurang bervariasi, dan pendekatan terpadu untuk mengajar IPS, sehingga tidak dapat direalisasikan oleh para guru karena berbagai kendala.   Kata kunci: pembelajaran, IPS, SMP, KTSP  

IP-10 is a potential biomarker of cystic fibrosis acute pulmonary exacerbations.

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George M Solomon

Full Text Available Cystic fibrosis (CF is characterized by acute pulmonary exacerbations (APE. The CF nasal airway exhibits a similar ion transport defect as the lung, and colonization, infection, and inflammation within the nasal passages are common among CF patients. Nasal lavage fluid (NLF is a minimally invasive means to collect upper airway samples.We collected NLF at the onset and resolution of CF APE and compared a 27-plex cytokine profile to stable CF outpatients and normal controls. We also tested IP-10 levels in the bronchoalveolar lavage fluid (BALF of CF patients. Well-differentiated murine sinonasal monolayers were exposed to bacterial stimulus, and IP-10 levels were measured to test epithelial secretion.Subjects hospitalized for APE had elevated IP-10 (2582 pg/mL [95% CL of mean: 818,8165], N=13 which significantly decreased (647 pg/mL [357,1174], P<0.05, N =13 following antimicrobial therapy. Stable CF outpatients exhibited intermediately elevated levels (680 pg/mL [281,1644], N=13 that were less than CF inpatients upon admission (P=0.056 but not significantly different than normal controls (342 pg/mL [110,1061]; P=0.3, N=10. IP-10 was significantly increased in CF BALF (2673 pg/mL [1306,5458], N=10 compared to healthy post-lung transplant patients (8.4 pg/mL [0.03,2172], N=5, P<0.001. IP-10 levels from well-differentiated CF murine nasal epithelial monolayers exposed to Pseudomonas PAO-1 bacteria-free prep or LPS (100 nM apically for 24 hours were significantly elevated (1159 ± 147, P<0.001 for PAO-1; 1373 ± 191, P<0.001 for LPS vs. 305 ± 68 for vehicle controls. Human sino-nasal epithelial cells derived from CF patients had a similar response to LPS (34% increase, P<0.05, N=6.IP-10 is elevated in the nasal lavage of CF patients with APE and responds to antimicrobial therapy. IP-10 is induced by airway epithelia following stimulation with bacterial pathogens in a murine model. Additional research regarding IP-10 as a potential biomarker is

Analysis of Handoff Mechanisms in Mobile IP

Science.gov (United States)

Jayaraj, Maria Nadine Simonel; Issac, Biju; Haldar, Manas Kumar

2011-06-01

One of the most important challenges in mobile Internet Protocol (IP) is to provide service for a mobile node to maintain its connectivity to network when it moves from one domain to another. IP is responsible for routing packets across network. The first major version of IP is the Internet Protocol version 4 (IPv4). It is one of the dominant protocols relevant to wireless network. Later a newer version of IP called the IPv6 was proposed. Mobile IPv6 is mainly introduced for the purpose of mobility. Mobility management enables network to locate roaming nodes in order to deliver packets and maintain connections with them when moving into new domains. Handoff occurs when a mobile node moves from one network to another. It is a key factor of mobility because a mobile node can trigger several handoffs during a session. This paper briefly explains on mobile IP and its handoff issues, along with the drawbacks of mobile IP.

IP3 levels and their modulation FY fusicoccin measured by a novel [3H] IP3 binding assay

International Nuclear Information System (INIS)

Aducci, P.; Marra, M.

1990-01-01

A recently developed sensitive assay based on the binding reaction of IP3 to bovine adrenal preparations has been utilized for determining the level of endogenous inositol-1,4,5 trisphosphate (IP3) in maize roots and coleoptiles. The amount of IP3 found in these tissues ranges from 0.1 to 1.0 nmol g-1 fresh weight. Reproducible results were obtained with extracts of tissues from a same harvest, while they showed a 2-3 fold variation when different batches of plantlets were compared. The fungal phytotoxin fusicoccin (FC) known to affect several physiological processes in higher plants, increases the level of IP3 in coleoptiles. This observation suggests that IP3 might be involved in the transduction of the FC encoded signal from its receptors at the plasmalemma level to the cell machinery

A Learning-Based Approach for IP Geolocation

Science.gov (United States)

Eriksson, Brian; Barford, Paul; Sommers, Joel; Nowak, Robert

The ability to pinpoint the geographic location of IP hosts is compelling for applications such as on-line advertising and network attack diagnosis. While prior methods can accurately identify the location of hosts in some regions of the Internet, they produce erroneous results when the delay or topology measurement on which they are based is limited. The hypothesis of our work is that the accuracy of IP geolocation can be improved through the creation of a flexible analytic framework that accommodates different types of geolocation information. In this paper, we describe a new framework for IP geolocation that reduces to a machine-learning classification problem. Our methodology considers a set of lightweight measurements from a set of known monitors to a target, and then classifies the location of that target based on the most probable geographic region given probability densities learned from a training set. For this study, we employ a Naive Bayes framework that has low computational complexity and enables additional environmental information to be easily added to enhance the classification process. To demonstrate the feasibility and accuracy of our approach, we test IP geolocation on over 16,000 routers given ping measurements from 78 monitors with known geographic placement. Our results show that the simple application of our method improves geolocation accuracy for over 96% of the nodes identified in our data set, with on average accuracy 70 miles closer to the true geographic location versus prior constraint-based geolocation. These results highlight the promise of our method and indicate how future expansion of the classifier can lead to further improvements in geolocation accuracy.

Involvement of dopamine D1/D2 receptors on harmane-induced amnesia in the step-down passive avoidance test.

Science.gov (United States)

Nasehi, Mohammad; Piri, Morteza; Nouri, Maryam; Farzin, Davood; Nayer-Nouri, Touraj; Zarrindast, Mohammad Reza

2010-05-25

Ingestion of harmane and other alkaloids derived from plant Peganum harmala has been shown to elicit profound behavioural and toxic effects in humans, including hallucinations, excitation, feelings of elation, and euphoria. These alkaloids in the high doses can cause a toxic syndrome characterized by tremors and convulsions. Harmane has also been shown to act on a variety of receptor systems in the mammalian brain, including those for serotonin, dopamine and benzodiazepines. In animals, it has been reported to affect short and long term memory. In the present study, effects of dopamine D1 and D2 receptor antagonists on the harmane (HA)-induced amnesia and exploratory behaviors were examined in mice. One-trial step-down and hole-board paradigms were used for the assessment of memory retention and exploratory behaviors in adult male NMRI mice respectively. Intraperitoneal (i.p.) administration of HA (5 and 10 mg/kg) immediately after training decreased memory consolidation, while had no effect on anxiety-like behavior. Memory retrieval was not altered by 15- or 30 min pre-testing administration of the D1 (SCH23390, 0.025, 0.05 and 0.1 mg/kg) or D2 (sulpiride 12.5, 25 and 50 mg/kg) receptor antagonists, respectively. In contrast, SCH23390 (0.05 and 0.1 mg/kg) or sulpiride (25 and 50 mg/kg) pre-test administration fully reversed HA-induced impairment of memory consolidation. Finally, neither D1 nor D2 receptor blockade affected exploratory behaviors in the hole-board paradigm. Altogether, these findings strongly suggest an involvement of D1 and D2 receptors modulation in the HA-induced impairment of memory consolidation. Copyright 2010 Elsevier B.V. All rights reserved.

Canceling Some d-CON Mouse and Rat Control Products

Science.gov (United States)

EPA has reached agreement with the manufacturer, to cancel 12 d-CON products that do not meet our testing protocols that better protect children, pets and non-target wildlife from accidental exposure to the pesticide. These products will be phased out.

[Microstructure and mechanical property of a new IPS-Empress 2 dental glass-ceramic].

Science.gov (United States)

Luo, Xiao-ping; Watts, D C; Wilson, N H F; Silsons, N; Cheng, Ya-qin

2005-03-01

To investigate the microstructure and mechanical properties of a new IPS-Empress 2 dental glass-ceramic. AFM, SEM and XRD were used to analyze the microstructure and crystal phase of IPS-Empress 2 glass-ceramic. The flexural strength and fracture toughness were tested using 3-point bending method and indentation method respectively. IPS-Empress 2 glass-ceramic mainly consisted of lithium disilicate crystal, lithium phosphate and glass matrix, which formed a continuous interlocking structure. The crystal phases were not changed before and after hot-pressed treatment. AFM showed nucleating agent particles of different sizes distributed on the highly polished ceramic surface. The strength and fracture toughness were 300 MPa and 3.1 MPam(1/2). The high strength and fracture toughness of IPS-Empress 2 glass ceramic are attributed to the fine lithium disilicate crystalline, interlocking microstructure and crack deflection.

Intellectual Property and Strategic Agreements (IP/SA) | FNLCR

Science.gov (United States)

What does IP/SA handle? IP/SA handles all invention issues including patents and copyrights. All employee inventionreports are filed through the IP/SA office for all activities under the OTS contract.Additionally,&nbs

Opportunities for IP  in Communications Beyond 3G

DEFF Research Database (Denmark)

Nielsen, Thomas Toftegaard; Jacobsen, Rune H.

2005-01-01

Future communication will be based on TCP/IP as common network and transport layers to provide global connectivity to users and applications. IP is used to provide ubiquitous access across different access networks and exploits the benefits of a common connectivity layer while reducing the cost...... of operation and maintenance of the network. This paper discusses the opportunities for IP in the evolution towards a future broadband, all-IP mobile communication network. In particular, we argue for three opportunities for the future: Interworking access technologies over IP, IP layer transparency...

Test Beam Results of a 3D Diamond Detector

CERN Document Server

Dunser, Marc

2015-01-01

3D pixel technology has been used successfully in the past with silicon detectors for tracking applications. Recently, a first prototype of the same 3D technology has been produced on a chemical vapour deposited single-crystal diamond sensor. This device has been subsequently tested in a beam test at CERN’s SPS accelerator in a beam of 120 GeV protons. Details on the production and results of testbeam data are presented.

GMI-IPS: Python Processing Software for Aircraft Campaigns

Science.gov (United States)

Damon, M. R.; Strode, S. A.; Steenrod, S. D.; Prather, M. J.

2018-01-01

spatial grid of the flight path as defined by the pressure, latitude, and longitude points at each flight time record, a weighted average is then calculated from the nearest neighbors in two dimensions (latitude, longitude). Using SciPya's Regular Grid Interpolator, interpolation functions are generated for the GMI model grid and the calculated weighted averages. The flight path points are then extracted from the ATom ICARTT instrument file, and are sent to the multi-dimensional interpolating functions to generate GMI field quantities along the spatial path of the flight. The interpolated field quantities are then written to a ICARTT data file, which is stored for further manipulation. The GMI-IPS is aware of a generic ATom ICARTT header format, containing basic information for all flight campaigns. The GMI-IPS includes logic to edit metadata for the derived field quantities, as well as modify the generic header data such as processing dates and associated instrument files. The ICARTT interpolated data is then appended to the modified header data, and the ICARTT processing is complete for the given flight and ready for collaboration. The output ICARTT data adheres to the ICARTT file format standards V1.1. The visualization component of the GMI-IPS uses Matplotlib extensively and has several functions ranging in complexity. First, it creates a model background curtain for the flight (time versus model eta levels) with the interpolated flight data superimposed on the curtain. Secondly, it creates a time-series plot of the interpolated flight data. Lastly, the visualization component creates averaged 2D model slices (longitude versus latitude) with overlaid flight track circles at key pressure levels. The GMI-IPS consists of a handful of classes and supporting functionality that have been generalized to be compatible with any ICARTT file that adheres to the base class definition. The base class represents a generic ICARTT entry, only defining a single time entry and 3D

Mobile IP

NARCIS (Netherlands)

Heijenk, Geert; Sallent, S.; Pras, Aiko

1999-01-01

The Internet is growing exponentially, both in the amount of traffic carried, and in the amount of hosts connected. IP technology is becoming more and more important, in company networks (Intranets), and also in the core networks for the next generation mobile networks. Further, wireless access to

Astrocyte IP3R2-dependent Ca2+ signaling is not a major modulator of neuronal pathways governing behavior.

Directory of Open Access Journals (Sweden)

Jeremy ePetravicz

2014-11-01

Full Text Available Calcium-dependent release of gliotransmitters by astrocytes is reported to play a critical role in synaptic transmission and be necessary for long-term potentiation (LTP, long-term depression (LTD and other forms of synaptic modulation that are correlates of learning and memory . Further, physiological processes reported to be dependent on Ca2+ fluxes in astrocytes include functional hyperemia, sleep, and regulation of breathing. The preponderance of findings indicate that most, if not all, receptor dependent Ca2+ fluxes within astrocytes are due to release of Ca2+ through IP3 receptor/channels in the endoplasmic reticulum. Findings from several laboratories indicate that astrocytes only express IP3 receptor type 2 (IP3R2 and that a knockout of IP3R2 obliterates the GPCR-dependent astrocytic Ca2+ responses. Assuming that astrocytic Ca2+ fluxes play a critical role in synaptic physiology, it would be predicted that eliminating of astrocytic Ca2+ fluxes would lead to marked changes in behavioral tests. Here, we tested this hypothesis by conducting a broad series of behavioral tests that recruited multiple brain regions, on an IP3R2 conditional knockout mouse model. We present the novel finding that behavioral processes are unaffected by lack of astrocyte IP3R-mediated Ca2+ signals. IP3R2 cKO animals display no change in anxiety or depressive behaviors, and no alteration to motor and sensory function. Morris water maze testing, a behavioral correlate of learning and memory, was unaffected by lack of astrocyte IP3R2-mediated Ca2+-signaling. Therefore, in contrast to the prevailing literature, we find that neither receptor-driven astrocyte Ca2+ fluxes nor, by extension, gliotransmission is likely to be a major modulating force on the physiological processes underlying behavior.

Cyclotron production of high-purity 123I for medical applications via the 127I(p,5n)123Xe → 123I nuclear reaction

International Nuclear Information System (INIS)

Lagunas-Solar, M.C.

1985-01-01

The use of iodine-123 in nuclear medicine procedures is well documented in the scientific literature. Also, several methods for its production based on accelerator techniques have been described. Indirectly made 123 I via the 127 I(p,5n) 123 Xe → 123 I reaction produces 123 I of > 99.9% radionuclidic purity, with only 125 I ( 123 I production were developed at the University of California at Davis, where since 1974 the 76-in. isochronous cyclotron of the Crocker Nuclear Laboratory has been used for routine biweekly production of high-purity no-carrier-added 123 I

Fish the ChIPs: a pipeline for automated genomic annotation of ChIP-Seq data

Directory of Open Access Journals (Sweden)

Minucci Saverio

2011-10-01

Full Text Available Abstract Background High-throughput sequencing is generating massive amounts of data at a pace that largely exceeds the throughput of data analysis routines. Here we introduce Fish the ChIPs (FC, a computational pipeline aimed at a broad public of users and designed to perform complete ChIP-Seq data analysis of an unlimited number of samples, thus increasing throughput, reproducibility and saving time. Results Starting from short read sequences, FC performs the following steps: 1 quality controls, 2 alignment to a reference genome, 3 peak calling, 4 genomic annotation, 5 generation of raw signal tracks for visualization on the UCSC and IGV genome browsers. FC exploits some of the fastest and most effective tools today available. Installation on a Mac platform requires very basic computational skills while configuration and usage are supported by a user-friendly graphic user interface. Alternatively, FC can be compiled from the source code on any Unix machine and then run with the possibility of customizing each single parameter through a simple configuration text file that can be generated using a dedicated user-friendly web-form. Considering the execution time, FC can be run on a desktop machine, even though the use of a computer cluster is recommended for analyses of large batches of data. FC is perfectly suited to work with data coming from Illumina Solexa Genome Analyzers or ABI SOLiD and its usage can potentially be extended to any sequencing platform. Conclusions Compared to existing tools, FC has two main advantages that make it suitable for a broad range of users. First of all, it can be installed and run by wet biologists on a Mac machine. Besides it can handle an unlimited number of samples, being convenient for large analyses. In this context, computational biologists can increase reproducibility of their ChIP-Seq data analyses while saving time for downstream analyses. Reviewers This article was reviewed by Gavin Huttley, George

75 FR 13235 - IP-Enabled Services

Science.gov (United States)

2010-03-19

... FEDERAL COMMUNICATIONS COMMISSION 47 CFR Part 63 [WC Docket No. 04-36; FCC 09-40] IP-Enabled Services AGENCY: Federal Communications Commission ACTION: Final rule; announcement of effective date... Internet Protocol (VoIP) service the discontinuance obligations that apply to domestic non-dominant...

A Brazilian version of the "Children's Interview for Psychiatric Syndromes" (ChIPS A versão brasileira do "Children's Interview for Psychiatric Syndromes" (ChIPS

Directory of Open Access Journals (Sweden)

Isabella G. S. de Souza

2009-01-01

Full Text Available OBJETIVE: The advance of research in child and adolescent psychiatry in Brazil heavily depends on the existence of instruments for the investigation of psychiatric syndromes adapted to Brazilian Portuguese. METHODS: This article describes a careful process of translation of the Children's Interview for Psychiatric Syndromes for the purpose of use in research in Brazil. The Children's Interview for Psychiatric Syndromes has a version for parents (P-ChIPs and a version for children (ChIPS. In this article, the sections of P-ChIPS referring to attention-deficit hyperactivity disorder, oppositional-defiant disorder, conduct disorder, mania/hypomania, anorexia nervosa, bulimia nervosa and psychotic disorders were translated to Brazilian Portuguese. The sections of the ChIPS referring to substance use disorders, social anxiety disorder, specific phobias, obsessive-compulsive disorder, generalized anxiety disoder, separation anxiety disorder, post-traumatic disorders and depression/dysthimia were also adapted. Each section was translated by two independent translators and later discussed in a committee composed of experts in the field of Psychiatry and a professional of the field of linguistics. RESULT: A final version containing an interview for the main psychiatric syndromes was defined. CONCLUSION: The translated P-ChIPS is a helpful instrument in children and adolescent clinical evaluation.OBJETIVO: O avanço em pesquisa em psiquiatria da infância e adolescência no Brasil depende da existência de instrumentos para a investigação de síndromes psiquiátricas adaptadas à Língua Portuguesa. Este artigo descreve um cuidadoso processo de tradução do Children´s Interview for Psychiatric Syndromes para o uso em pesquisa no Brasil. MÉTODOS: O Children´s Interview for Psychiatric Syndromes tem uma versão para pais (P-ChIPs e uma versão para as crianças (ChIPs. Nesse artigo, as seções do P-ChIPs referentes ao transtorno do déficit de aten

The design of in-pile test section for fuel test loop

Energy Technology Data Exchange (ETDEWEB)

Park, K. N.; Lee, J. M.; Shim, B. S.; Zee, D. Y.; Park, S. H.; Ahn, S. H.; Lee, J. Y.; Kim, Y. J. [KAERI, Taejon (Korea, Republic of)

2004-07-01

As an equipment for nuclear fuel's general performance irradiation test in HANARO, Fuel Test Loop(FTL) has been developed that can irradiate the pin to the maximum number of 3 at the core irradiation hole(IR1 hole) by considering for it's utility and user's irradiation requirement. 3-Pin FTL consists of In-Pile Test Section (IPS) and Out-of-Pile System (OPS). IPS consists for IPS Vessel assembly, In-Pool Piping, IPS Support, In-Pool Piping Support etc. Design that such IPS considers interference item consisted to do not bear in existing facilities by one. IVA that is connected to the OPS are controlled and regulated by means of system pressure, system temperature and the water quality. IPS Vessel assembly is consisted of outer pressure vessel, inner pressure vessel, IPS head, inner assembly and test fuel carrier. After 3-Pin FTL development which is expected to be finished by the 2006, FTL will be used for the irradiation test of the new PWR-type fuel and can maximize the usage of HANARO.

Agency IP Data

Data.gov (United States)

National Aeronautics and Space Administration — Public data set for NASA Agency Intellectual Property (IP). The distribution contains both Patent information as well as General Release of Open Source Software.

Age-dependent changes in diastolic Ca2+ and Na+ concentrations in dystrophic cardiomyopathy: Role of Ca2+ entry and IP3

International Nuclear Information System (INIS)

Mijares, Alfredo; Altamirano, Francisco; Kolster, Juan; Adams, José A.; López, José R.

2014-01-01

Highlights: • Age-dependent increase in [Ca 2+ ] d and [Na + ] d in mdx cardiomyocytes. • Gadolinium significantly reduced both [Ca 2+ ] d and [Na + ] d at all ages. • IP 3 -pathway inhibition reduced cations concentrations in dystrophic cardiomyocytes. - Abstract: Duchenne muscular dystrophy (DMD) is a lethal X-inherited disease caused by dystrophin deficiency. Besides the relatively well characterized skeletal muscle degenerative processes, DMD is also associated with a dilated cardiomyopathy that leads to progressive heart failure at the end of the second decade. The aim of the present study was to characterize the diastolic Ca 2+ concentration ([Ca 2+ ] d ) and diastolic Na + concentration ([Na + ] d ) abnormalities in cardiomyocytes isolated from 3-, 6-, 9-, and 12-month old mdx mice using ion-selective microelectrodes. In addition, the contributions of gadolinium (Gd 3+ )-sensitive Ca 2+ entry and inositol triphosphate (IP 3 ) signaling pathways in abnormal [Ca 2+ ] d and [Na + ] d were investigated. Our results showed an age-dependent increase in both [Ca 2+ ] d and [Na + ] d in dystrophic cardiomyocytes compared to those isolated from age-matched wt mice. Gd 3+ treatment significantly reduced both [Ca 2+ ] d and [Na + ] d at all ages. In addition, blockade of the IP 3 -pathway with either U-73122 or xestospongin C significantly reduced ion concentrations in dystrophic cardiomyocytes. Co-treatment with U-73122 and Gd 3+ normalized both [Ca 2+ ] d and [Na + ] d at all ages in dystrophic cardiomyocytes. These data showed that loss of dystrophin in mdx cardiomyocytes produced an age-dependent intracellular Ca 2+ and Na + overload mediated at least in part by enhanced Ca 2+ entry through Gd 3+ sensitive transient receptor potential channels (TRPC), and by IP 3 receptors

Research of future network with multi-layer IP address

Science.gov (United States)

Li, Guoling; Long, Zhaohua; Wei, Ziqiang

2018-04-01

The shortage of IP addresses and the scalability of routing systems [1] are challenges for the Internet. The idea of dividing existing IP addresses between identities and locations is one of the important research directions. This paper proposed a new decimal network architecture based on IPv9 [11], and decimal network IP address from E.164 principle of traditional telecommunication network, the IP address level, which helps to achieve separation and identification and location of IP address, IP address form a multilayer network structure, routing scalability problem in remission at the same time, to solve the problem of IPv4 address depletion. On the basis of IPv9, a new decimal network architecture is proposed, and the IP address of the decimal network draws on the E.164 principle of the traditional telecommunication network, and the IP addresses are hierarchically divided, which helps to realize the identification and location separation of IP addresses, the formation of multi-layer IP address network structure, while easing the scalability of the routing system to find a way out of IPv4 address exhausted. In addition to modifying DNS [10] simply and adding the function of digital domain, a DDNS [12] is formed. At the same time, a gateway device is added, that is, IPV9 gateway. The original backbone network and user network are unchanged.

IP Address Management Principles and Practice

CERN Document Server

Rooney, Timothy

2010-01-01

This book will be the first covering the subject of IP address management (IPAM). The practice of IPAM includes the application of network management disciplines to IP address space and associated network services, namely DHCP (Dynamic Host Configuration Protocol) and DNS (Domain Name System). The consequence of inaccurately configuring DHCP is that end users may not be able to obtain IP addresses to access the network. Without proper DNS configuration, usability of the network will greatly suffer as the name-to-address lookup process may fail. Imagine having to navigate to a website or send a

Possible detection of an emission feature near 584 A in the direction of G191-B2B

Science.gov (United States)

Green, James; Bowyer, Stuart; Jelinsky, Patrick

1990-01-01

A possible spectral emission feature is reported in the direction of the nearby hot white dwarf G191-B2B at 581.5 + or - 6 A with a significance of 3.8 sigma. This emission has been identified as He I 584.3 A. The emission cannot be due to local geocoronal emission or interplanetary backscatter of solar He I 584 A emission because the feature is not detected in a nearby sky exposure. Possible sources for this emission are examined, including the photosphere of G191-B2B, the comparison star G191-B2A, and a possible nebulosity near or around G191-B2B. The parameters required to explain the emission are derived for each case. All of these explanations require unexpected physical conditions; hence we believe this result must receive confirming verification despite the statistical likelihood of the detection.

Possible detection of an emission feature near 584 A in the direction of G191-B2B

International Nuclear Information System (INIS)

Green, J.; Bowyer, S.; Jelinsky, P.

1990-01-01

A possible spectral emission feature is reported in the direction of the nearby hot white dwarf G191-B2B at 581.5 + or - 6 A with a significance of 3.8 sigma. This emission has been identified as He I 584.3 A. The emission cannot be due to local geocoronal emission or interplanetary backscatter of solar He I 584 A emission because the feature is not detected in a nearby sky exposure. Possible sources for this emission are examined, including the photosphere of G191-B2B, the comparison star G191-B2A, and a possible nebulosity near or around G191-B2B. The parameters required to explain the emission are derived for each case. All of these explanations require unexpected physical conditions; hence we believe this result must receive confirming verification despite the statistical likelihood of the detection. 15 refs

MD#1182: Calibration of diamond particle detectors in IP6

CERN Document Server

Valette, Matthieu; Lindstrom, Bjorn Hans Filip; Wiesner, Christoph

2017-01-01

In case of an asynchronous beam dump with a fully filled LHC machine it is expected that all standard ionisation chamber Beam Loss Monitors (IC BLM) around the LHC dumping region in IP6 will be saturated. Diamond Beam Loss Monitors (dBLM) were therefore installed next to the movable dump protection absorber (TCDQ) downstream of the extraction kickers. These detectors allow resolving losses at a nanosecond timescale and with an dynamic range of several orders of magnitude; thus, allowing to know the number of nominal bunches impacting the TCDQ. After a first series of calibrations using asynchronous beam dump tests, an experiment was conducted during MD#1182 to demonstrate the possibility of resolving a nominal bunch hitting the TCDQ. The impact parameter of the bunches on the TCDQ was first scanned using probe bunches with lower intensity then tests were done with nominal bunches (1.1e11 p/bunch) at injection energy. High energy calibration of the losses was also attempted unsuccessfully. Due to different beh...

Post-translational inhibition of IP-10 secretion in IEC by probiotic bacteria: impact on chronic inflammation.

Directory of Open Access Journals (Sweden)

Gabriele Hoermannsperger

Full Text Available BACKGROUND: Clinical and experimental studies suggest that the probiotic mixture VSL#3 has protective activities in the context of inflammatory bowel disease (IBD. The aim of the study was to reveal bacterial strain-specific molecular mechanisms underlying the anti-inflammatory potential of VSL#3 in intestinal epithelial cells (IEC. METHODOLOGY/PRINCIPAL FINDINGS: VSL#3 inhibited TNF-induced secretion of the T-cell chemokine interferon-inducible protein (IP-10 in Mode-K cells. Lactobacillus casei (L. casei cell surface proteins were identified as active anti-inflammatory components of VSL#3. Interestingly, L. casei failed to block TNF-induced IP-10 promoter activity or IP-10 gene transcription at the mRNA expression level but completely inhibited IP-10 protein secretion as well as IP-10-mediated T-cell transmigration. Kinetic studies, pulse-chase experiments and the use of a pharmacological inhibitor for the export machinery (brefeldin A showed that L. casei did not impair initial IP-10 production but decreased intracellular IP-10 protein stability as a result of blocked IP-10 secretion. Although L. casei induced IP-10 ubiquitination, the inhibition of proteasomal or lysosomal degradation did not prevent the loss of intracellular IP-10. Most important for the mechanistic understanding, the inhibition of vesicular trafficking by 3-methyladenine (3-MA inhibited IP-10 but not IL-6 expression, mimicking the inhibitory effects of L. casei. These findings suggest that L. casei impairs vesicular pathways important for the secretion of IP-10, followed by subsequent degradation of the proinflammatory chemokine. Feeding studies in TNF(DeltaARE and IL-10(-/- mice revealed a compartimentalized protection of VSL#3 on the development of cecal but not on ileal or colonic inflammation. Consistent with reduced tissue pathology in IL-10(-/- mice, IP-10 protein expression was reduced in primary epithelial cells. CONCLUSIONS/SIGNIFICANCE: We demonstrate segment

Parallel factor ChIP provides essential internal control for quantitative differential ChIP-seq.

Science.gov (United States)

Guertin, Michael J; Cullen, Amy E; Markowetz, Florian; Holding, Andrew N

2018-04-17

A key challenge in quantitative ChIP combined with high-throughput sequencing (ChIP-seq) is the normalization of data in the presence of genome-wide changes in occupancy. Analysis-based normalization methods were developed for transcriptomic data and these are dependent on the underlying assumption that total transcription does not change between conditions. For genome-wide changes in transcription factor (TF) binding, these assumptions do not hold true. The challenges in normalization are confounded by experimental variability during sample preparation, processing and recovery. We present a novel normalization strategy utilizing an internal standard of unchanged peaks for reference. Our method can be readily applied to monitor genome-wide changes by ChIP-seq that are otherwise lost or misrepresented through analytical normalization. We compare our approach to normalization by total read depth and two alternative methods that utilize external experimental controls to study TF binding. We successfully resolve the key challenges in quantitative ChIP-seq analysis and demonstrate its application by monitoring the loss of Estrogen Receptor-alpha (ER) binding upon fulvestrant treatment, ER binding in response to estrodiol, ER mediated change in H4K12 acetylation and profiling ER binding in patient-derived xenographs. This is supported by an adaptable pipeline to normalize and quantify differential TF binding genome-wide and generate metrics for differential binding at individual sites.

Dynamic Mobile IP routers in ad hoc networks

NARCIS (Netherlands)

Kock, B.A.; Schmidt, J.R.

2005-01-01

This paper describes a concept combining mobile IP and ad hoc routing to create a robust mobile network. In this network all nodes are mobile and globally and locally reachable under the same IP address. Essential for implementing this network are the dynamic mobile IP routers. They act as gateways

VoIP over WLAN

OpenAIRE

Nikkari, Joni

2007-01-01

Tässä opinnäytetyössä tutkitaan VoIP over WLAN -tekniikan mahdollisuuksia nykyaikaisessa käyttöympäristössä, sekä yritysmaailman että kotikäyttäjän näkökulmasta. Toimiakseen VoWLAN tarvitsee kaksi eri tekniikkaa: langattoman lähiverkon sekä WLAN-puhelimen, joka perustuu VoIP-tekniikkaan.; WLAN:ssa tietoliikenne kulkee normaalin kaapeloinnin sijasta radiotaajuuksia käyttämällä. Standardina toimii IEEE 802.11, joka määrittelee WLAN-verkkojen toiminnan. Standardia on kehitetty jatkuvasti, ja si...

Presynaptic Dopamine D2 Receptors Modulate [3H]GABA Release at StriatoPallidal Terminals via Activation of PLC → IP3 → Calcineurin and Inhibition of AC → cAMP → PKA Signaling Cascades.

Science.gov (United States)

Jijón-Lorenzo, Rafael; Caballero-Florán, Isaac Hiram; Recillas-Morales, Sergio; Cortés, Hernán; Avalos-Fuentes, José Arturo; Paz-Bermúdez, Francisco Javier; Erlij, David; Florán, Benjamín

2018-02-21

Striatal dopamine D2 receptors activate the PLC → IP3 → Calcineurin-signaling pathway to modulate the neural excitability of En+ Medium-sized Spiny GABAergic neurons (MSN) through the regulation of L-type Ca 2+ channels. Presynaptic dopaminergic D2 receptors modulate GABA release at striatopallidal terminals through L-type Ca 2+ channels as well, but their signaling pathway is still undetermined. Since D2 receptors are Gi/o-coupled and negatively modulate adenylyl cyclase (AC), we investigated whether presynaptic D2 receptors modulate GABA release through the same signaling cascade that controls excitability in the striatum or by the inhibition of AC and decreased PKA activity. Activation of D2 receptors stimulated formation of [ 3 H]IP 1 and decreased Forskolin-stimulated [ 3 H]cAMP accumulation in synaptosomes from rat Globus Pallidus. D2 receptor activation with Quinpirole in the presence of L 745,870 decreased, in a dose-dependent manner, K + -induced [ 3 H]GABA release in pallidal slices. The effect was prevented by the pharmacological blockade of Gi/o βγ subunit effects with Gallein, PLC with U 73122, IP3 receptor activation with 4-APB, Calcineurin with FK506. In addition, when release was stimulated with Forskolin to activate AC, D2 receptors also decreased K + -induced [ 3 H]GABA release, an effect occluded with the effect of the blockade of PKA with H89 or stimulation of release with the cAMP analog 8-Br-cAMP. These data indicate that D2 receptors modulate [ 3 H]GABA release at striatopallidal terminals by activating the PLC → IP3 → Calcineurin-signaling cascade, the same one that modulates excitability in soma. Additionally, D2 receptors inhibit release when AC is active. Both mechanisms appear to converge to regulate the activity of presynaptic L-type Ca 2+ channels. Copyright © 2018 IBRO. Published by Elsevier Ltd. All rights reserved.

Lessons Learned from resolving massive IPS database change for SPADES+

Energy Technology Data Exchange (ETDEWEB)

Kim, Jin-Soo [KEPCO Engineering and Construction Co., Deajeon (Korea, Republic of)

2016-10-15

Safety Parameter Display and Evaluation System+ (SPADES+) was implemented to meet the requirements for Safety Parameter Display System (SPDS) which are related to TMI Action Plan requirements. SPADES+ monitors continuously the critical safety function during normal, abnormal, and emergency operation mode and generates the alarm output to the alarm server when the tolerance related to safety functions are not satisfied. The alarm algorithm for critical safety function is performed in the NSSS Application Software (NAPS) server of the Information Process System (IPS) and the calculation result will be displayed on the flat panel display (FPD) of the IPS. SPADES+ provides the critical variable to the control room operators to aid them in rapidly and reliable determining the safety status of the plant. Many database point ID names (518 points) were changed. POINT{sub I}D is used in the programming source code, the related documents such as SDS and SRS, and Graphic database. To reduce human errors, computer program and office program’s Macro are used. Though the automatic methods are used for changing POINT{sub I}Ds, it takes lots of time to resolve for editing the change list except for making computerized solutions. In IPS, there are many more programs than SPADES+ and over 30,000 POINT{sub I}Ds are in IPS database. Changing POINT{sub I}Ds could be a burden to software engineers. In case of Ovation system database, there is the Alias field to prevent this kind of problem. The Alias is a kind of secondary key in database.

Testing strategies in mutagenicity and genetic toxicology: an appraisal of the guidelines of the European Scientific Committee for Cosmetics and Non-Food Products for the evaluation of hair dyes.

Science.gov (United States)

Kirkland, D J; Henderson, L; Marzin, D; Müller, L; Parry, J M; Speit, G; Tweats, D J; Williams, G M

2005-12-30

The European Scientific Committee on Cosmetics and Non-Food Products (SCCNFP) guideline for testing of hair dyes for genotoxic/mutagenic/carcinogenic potential has been reviewed. The battery of six in vitro tests recommended therein differs substantially from the batteries of two or three in vitro tests recommended in other guidelines. Our evaluation of the chemical types used in hair dyes and comparison with other guidelines for testing a wide range of chemical substances, lead to the conclusion that potential genotoxic activity may effectively be determined by the application of a limited number of well-validated test systems that are capable of detecting induced gene mutations and structural and numerical chromosomal changes. We conclude that highly effective screening for genotoxicity of hair dyes can be achieved by the use of three assays, namely the bacterial gene mutation assay, the mammalian cell gene mutation assay (mouse lymphoma tk assay preferred) and the in vitro micronucleus assay. These need to be combined with metabolic activation systems optimised for the individual chemical types. Recent published evidence [D. Kirkland, M. Aardema, L. Henderson, L. Müller, Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens. I. Sensitivity, specificity and relative predictivity, Mutat. Res. 584 (2005) 1-256] suggests that our recommended three tests will detect all known genotoxic carcinogens, and that increasing the number of in vitro assays further would merely reduce specificity (increase false positives). Of course there may be occasions when standard tests need to be modified to take account of special situations such as a specific pathway of biotransformation, but this should be considered as part of routine testing. It is clear that individual dyes and any other novel ingredients should be tested in this three-test battery. However, new products are formed on the scalp by

Redox routes to substitution of aluminum(III): synthesis and characterization of (IP-)2AlX (IP = α-iminopyridine, X = Cl, Me, SMe, S2CNMe2, C≡CPh, N3, SPh, NHPh).

Science.gov (United States)

Myers, Thomas W; Holmes, Alexandra L; Berben, Louise A

2012-08-20

Redox active ligands are shown to facilitate a variety of group transfer reactions at redox inert aluminum(III). Disulfides can be used as a two-electron group transfer reagent, and we show that (IP(-))(2)AlSR can be formed by reaction of [(THF)(6)Na][(IP(2-))(2)Al] (1c) with disulfides RSSR (where X = C(S)NMe(2), 4; SMe, 5). In a more general redox route to substitution of aluminum bis(iminopyridine) complexes, we report zinc(II) salts as a group transfer reagent. Reaction of [((R)IP(2-))(2)Al](-) (R = H, 1c; Me, 1d) with ZnX(2) affords ((R)IP(-))(2)AlX (where IP = iminopyridine, R = H, and X = Cl, 2; CCPh, 6; N(3), 7; SPh, 8; or R = Me and X = NHPh, 9). Single crystal X-ray diffraction analysis of the complexes reveal that each of the five coordinate complexes reported here has a trigonal bipyramidal geometry with τ = 0.668 - 0.858. We observed a correlation between the greatest deviations from ideal trigonal bipyramidal symmetry (lowest τ values), the bond lengths consistent with smallest degree of ligand reduction, and the least polarizable X ligand in (IP(-))(2)AlX. Complex 4 is six-coordinate and is best described as distorted octahedral. Variable temperature magnetic susceptibility measurements indicate that each of the complexes 3-9 has a biradical electronic structure similar to previously reported 2. Magnetic exchange coupling constants in the range J = -94 to -212 cm(-1) were fit to the data for 2-9 to describe the energy of antiferromagnetic interaction between ligand radicals assuming a spin Hamiltonian of the form Ĥ = -2JŜ(L(1))·Ŝ(L(2)). The strongest coupling occurs when the angle between the ligand planes is smallest, presumably to afford good overlap with the Al-X σ* orbital. Electrochemical properties of the complexes were probed using cyclic voltammetry and each of 3-9 displayed a reversible two-electron reduction and two quasi-reversible one-electron oxidation processes. The energy of the ligand based redox processes for 2-9 differ by

Protection against cancer by dietary IP6 and inositol.

Science.gov (United States)

Vucenik, Ivana; Shamsuddin, AbulKalam M

2006-01-01

Inositol hexaphosphate (IP(6)) is a naturally occurring polyphosphorylated carbohydrate, abundantly present in many plant sources and in certain high-fiber diets, such as cereals and legumes. In addition to being found in plants, IP(6) is contained in almost all mammalian cells, although in much smaller amounts, where it is important in regulating vital cellular functions such as signal transduction, cell proliferation, and differentiation. For a long time IP(6) has been recognized as a natural antioxidant. Recently IP(6) has received much attention for its role in cancer prevention and control of experimental tumor growth, progression, and metastasis. In addition, IP(6) possesses other significant benefits for human health, such as the ability to enhance immune system, prevent pathological calcification and kidney stone formation, lower elevated serum cholesterol, and reduce pathological platelet activity. In this review we show the efficacy and discuss some of the molecular mechanisms that govern the action of this dietary agent. Exogenously administered IP(6) is rapidly taken up into cells and dephosphorylated to lower inositol phosphates, which further affect signal transduction pathways resulting in cell cycle arrest. A striking anticancer action of IP(6) was demonstrated in different experimental models. In addition to reducing cell proliferation, IP(6) also induces differentiation of malignant cells. Enhanced immunity and antioxidant properties also contribute to tumor cell destruction. Preliminary studies in humans show that IP(6) and inositol, the precursor molecule of IP(6), appear to enhance the anticancer effect of conventional chemotherapy, control cancer metastases, and improve quality of life. Because it is abundantly present in regular diet, efficiently absorbed from the gastrointestinal tract, and safe, IP(6) + inositol holds great promise in our strategies for cancer prevention and therapy. There is clearly enough evidence to justify the

Ifabiyi, IP

African Journals Online (AJOL)

Ifabiyi, IP. Vol 11, No 1 (2013) - Articles Analysis of the Impacts of Rainfall Variability on Public Water Supply in Ilorin, Nigeria Abstract. ISSN: 2006-7003. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of ...

Cognitive Status Correlates with CXCL10/IP-10 Levels in Parkinson’s Disease

Directory of Open Access Journals (Sweden)

Natália Pessoa Rocha

2014-01-01

Full Text Available Cognitive impairment and depressive symptoms are of great interest in Parkinson’s disease (PD, since they are very common and lead to increased disability with poor quality of life. Inflammatory mechanisms have been implicated in PD and its nonmotor symptoms. In the current pilot study, we aimed to evaluate plasma levels of chemokines in PD patients and to analyze the putative association of chemokines with depressive symptoms and cognitive performance. We hypothesized that higher chemokines levels are associated with worse cognitive performance and increased depressive symptoms in PD. For this purpose, 40 PD patients and 25 age- and gender-matched controls were subjected to a clinical evaluation including cognitive and mood tests. Peripheral blood was drawn and plasma levels of CCL2/MCP-1, CCL11/eotaxin, CCL24/eotaxin-2, and CXCL10/IP-10 were measured by enzyme-linked immunosorbent assay. PD patients and control individuals presented comparable plasma concentrations of all the evaluated chemokines. In PD patients, CXCL10/IP-10 plasma levels correlated positively with Hoehn and Yahr staging scale. In addition, the higher CXCL10/IP-10 levels, the worse performance on cognitive tests. Although there was no significant difference between PD patients and control individuals regarding chemokines levels, our preliminary results showed that CXCL10/IP-10 may be associated with cognitive status in PD.

Performances des applications IP dans les systèmes de communications par satellite : cas du DVB-RCS et du DVB-S2

OpenAIRE

Jegham , Nizar

2008-01-01

Despite of a number of IP satellite networks developed and deployed, only a limited number of studies and feedbacks about the performance is available. IP over satellite systems raises several constraints. One of the main reasons is the lack of adaptation of IP protocol, initially designed for terrestrial wired networks, to the large bandwidth delay product of the satellite media. Another reason is a lack of coordination between the IP protocol stack upper layer and the satellite MAC and phys...

D-Branes on K3-Fibrations

CERN Document Server

Kaste, P.; Lutken, C.A.; Walcher, Johannes

2000-01-01

B-type D-branes are constructed on two different K3-fibrations over IP_1 using boundary conformal field theory at the rational Gepner points of these models. The microscopic CFT charges are compared with the Ramond charges of D-branes wrapped on holomorphic cycles of the corresponding Calabi-Yau manifold. We study in particular D4-branes and bundles localized on the K3 fibers, and find agreement with expectations. This provides a further test of the boundary CFT approach to $D$-brane physics.

Pengaruh Pembelajaran IPS Berbasis Proyek Terhadap Persepsi Konsumsi Berkarakter Mahasiswa S1 Pendidikan IPS Universitas Negeri Malang

Directory of Open Access Journals (Sweden)

Khofifatu Rohmah Adi

2017-10-01

Full Text Available This study aims to determine the effect of the project-based learning social studies consumer perceptions of student character. Consumer perception of the character of this research is focused on the consumption of environmentally sound because it was found that the students are less concerned about the environment, especially the cleanliness class. This type of research including quasi experimental, aimed at assessing the effect of an action learning on students' perceptions before and after treatment. Subjects were students of 2015 batch S1 IPS which follows the introductory economics course. The instrument used to measure the consumption of environmentally sound perception using a questionnaire with Likert scale. Based on the homogeneity test the cognitive abilities of students conclusion has a homogeneous character and definitive experimental group and the control is done randomly. This study analyzed SPSS 22.0 for Windows using independent sample T-test. Results of the analysis showed that there were significant differences between the control and experimental class class. Therefore, it can be concluded that the application of project-based learning IPS effect on consumer perceptions of character. In project-based learning allows students trying to construct their own knowledge and actively involved in seeking information so it is expected that students are able to connect theory gained with the existing reality in the environment. Keywords: Project Based Learning, Perception Character consumption   http://dx.doi.org/10.17977/um022v1i12016p065

Split degenerate states and stable p+ip phases from holography

Energy Technology Data Exchange (ETDEWEB)

Nie, Zhang-Yu; Zeng, Hui [Kunming University of Science and Technology, Kunming (China); Key Laboratory of Theoretical Physics, Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing (China); Pan, Qiyuan [Hunan Normal Univ., Key Lab. of Low Dimensional Quantum Structures and Quantum Control of Ministry of Education, and Synergetic Innovation Center for Quantum Effects and Applications, Dept. of Physics, Changsha (China); Zeng, Hua-Bi [Yangzhou University, College of Physics Science and Technology, Yangzhou, Jiangsu (China); National Central University, Department of Physics, Chungli (China)

2017-02-15

In this paper, we investigate the p+ip superfluid phases in the complex vector field holographic p-wave model. We find that in the probe limit, the p+ip phase and the p-wave phase are equally stable, hence the p and ip orders can be mixed with an arbitrary ratio to form more general p+λip phases, which are also equally stable with the p-wave and p+ip phases. As a result, the system possesses a degenerate thermal state in the superfluid region. We further study the case on considering the back-reaction on the metric, and we find that the degenerate ground states will be separated into p-wave and p+ip phases, and the p-wave phase is more stable. Finally, due to the different critical temperature of the zeroth order phase transitions from p-wave and p+ip phases to the normal phase, there is a temperature region where the p+ip phase exists but the p-wave phase does not. In this region we find the stable holographic p+ip phase for the first time. (orig.)

IP- -: A Reduced Internet Protocol for Optical Packet Networking

Science.gov (United States)

Ohta, Masataka; Fujikawa, Kenji

IP- - is proposed as an Internet Protocol suitable for optical packet networking. As optical routers require much faster control than electric ones and lack of optical buffers other than those by fiber delay lines requires fixed time control, Internet Protocols must be at least as simple as IPv4 and much simpler than IPv6. IP- - also addresses issues of IP address space exhaustion and IP routing table explosion.

Combined DC resistivity and induced polarization (DC-IP) for mapping the internal composition of a mine waste rock pile in Nova Scotia, Canada

Science.gov (United States)

Power, Christopher; Tsourlos, Panagiotis; Ramasamy, Murugan; Nivorlis, Aristeidis; Mkandawire, Martin

2018-03-01

Mine waste rock piles (WRPs) can contain sulfidic minerals whose interaction with oxygen and water can generate acid mine drainage (AMD). Thus, WRPs can be a long-term source of environmental pollution. Since the generation of AMD and its release into the environment is dependent on the net volume and bulk composition of waste rock, effective characterization of WRPs is necessary for successful remedial design and monitoring. In this study, a combined DC resistivity and induced polarization (DC-IP) approach was employed to characterize an AMD-generating WRP in the Sydney Coalfield, Nova Scotia, Canada. Two-dimensional (2D) DC-IP imaging with 6 survey lines was performed to capture the full WRP landform. 2D DC results indicated a highly heterogeneous and moderately conductive waste rock underlain by a resistive bedrock containing numerous fractures. 2D IP (chargeability) results identified several highly-chargeable regions within the waste, with normalized chargeability delineating regions specific to waste mineralogy only. Three-dimensional (3D) DC-IP imaging, using 17 parallel lines on the plateau of the pile, was then used to focus on the composition of the waste rock. The full 3D inverted DC-IP distributions were used to identify coincident and continuous zones (isosurfaces) of low resistivity (0.4 mS/m) that were inferred as generated AMD (leachate) and stored AMD (sulfides), respectively. Integrated geological, hydrogeological and geochemical data increased confidence in the geoelectrical interpretations. Knowledge on the location of potentially more reactive waste material is extremely valuable for improved long-term AMD monitoring at the WRP.

Covert Channels in SIP for VoIP Signalling

Science.gov (United States)

Mazurczyk, Wojciech; Szczypiorski, Krzysztof

In this paper, we evaluate available steganographic techniques for SIP (Session Initiation Protocol) that can be used for creating covert channels during signaling phase of VoIP (Voice over IP) call. Apart from characterizing existing steganographic methods we provide new insights by introducing new techniques. We also estimate amount of data that can be transferred in signalling messages for typical IP telephony call.

DiffServ resource management in IP-based radio access networks

NARCIS (Netherlands)

Heijenk, Geert; Karagiannis, Georgios; Rexhepi, Vlora; Westberg, Lars; prof.dr. Prasad, R.; prof.dr. Bach Andersen, J.

2001-01-01

The increasing popularity of the Internet, the flexibility of IP, and the wide deployment of IP technologies, as well as the growth of mobile communications have driven the development of IP-based solutions for wireless networking. The introduction of IP-based transport in Radio Access Networks

Diseño de un laboratorio virtual de telefonía IP utilizando Elastix.

OpenAIRE

Castillo Borja, Víctor Leonel

2015-01-01

En la última década la telefonía IP ha alcanzado un gran desarrollo a nivel mundial debido a las ventajas económicas que esta trae consigo, ventajas estas que ha llevado a muchos a cuestionarse por el futuro de la telefonía tradicional. La idea fundamental de este trabajo de investigación es implementar una central telefónica IP bajo la distribución de software libre Elastix. Esta central telefónica y el analizador de protocolo Wireshark y softphones se utilizarán en el laboratorio de tele...

A fast neutron detector with IP by track measurement

International Nuclear Information System (INIS)

Miao Zhengqiang; Yang Jun; Zhang Qiang; Zhao Xiangfeng; Wang Daohua

2004-01-01

Imaging Plate(IP) is very sensitive to electric particles, especially to heavy ions. As we know, the recoiling protons are produced while fast neutrons scattered in light material containing hydrogen. When the recoiling proton enters in the sensitive layer of IP, a track will be recorded by IP. In this paper, a fast neutron detector based on IP and (n, p) reaction is described in detail, the detector's efficiency is studied also. (authors)

Extraction of Electronic Evidence from VoIP: Forensic Analysis of A Virtual Hard Disk Vs RAM

Directory of Open Access Journals (Sweden)

david irwin

2011-03-01

Full Text Available The popularity of Voice over the Internet Protocol (VoIP is increasing as the cost savings and ease of use is realised by a wide range of home and corporate users. However, the technology is also attractive to criminals. This is because VoIP is a global telephony service, in which it is difficult to verify the user’s identification. The security of placing such calls may also be appealing to criminals, as many implementations use strong encryption to secure both the voice payload as well as to control messages making monitoring such VoIP calls difficult since conventional methods such as wire-tapping is not applicable to VoIP calls. Therefore, other methods of recovering electronic evidence and information from VoIP are required.  This research looks at what protocol evidence remains after a VoIP call has taken place examining both a virtual hard disk and the Random Access Memory (RAM. This paper proposes a set of identifiable credentials based on packet header information contained within the VoIP protocol stack. A series of controlled tests were undertaken whereby these credentials were forensically searched for on a virtual machine which was used to make the VoIP call. This experiment was then repeated by a search for the same protocol credentials within the RAM.

Security risks in IP telephony

OpenAIRE

Řezáč, Filip; Vozňák, Miroslav

2010-01-01

This paper deals with VoIP communication security and various techniques of VoIP attacks. We divided these threats in several categories according to their specific behaviour and their impact on the affected system. We also tried to find effective methods to prevent or mitigate these attacks. We focused our work on Spam over Internet Telephony (SPIT) as a real threat for the future. We have developed both a tool generating SPIT attacks and AntiSPIT tool defending communication systems against...

Engineering of radioimmunoassay (RIA) IP10.1

International Nuclear Information System (INIS)

Hari Nurcahyadi

2010-01-01

Engineering of Radioimmunoassay (RIA) IP10.1 is an innovative by PRPN - BATAN in 2010. Innovations made to the device IP10.1 RIA is the sample changer system, sample changer system on the device RIA IP10.1 applied 2 linear axis system (X, Z) with AC servo motor. In the RIA IP10.1 also use 5 pieces of the detector, so the enumeration process 50 (Fifty) sample is expected to be faster. Like its predecessor, The whole enumeration, data collection procedures and mechanisms operating within this system is entirely controlled by a PC via an electronic module. Electronics module consists of a high voltage module, amplifier and signal processor module, the module enumerators, low-voltage module, the module driver motor controller and a USB interface. The data acquisition and communication system using a USB port with the computer. (author)

Non-viral generation of marmoset monkey iPS cells by a six-factor-in-one-vector approach.

Science.gov (United States)

Debowski, Katharina; Warthemann, Rita; Lentes, Jana; Salinas-Riester, Gabriela; Dressel, Ralf; Langenstroth, Daniel; Gromoll, Jörg; Sasaki, Erika; Behr, Rüdiger

2015-01-01

Groundbreaking studies showed that differentiated somatic cells of mouse and human origin could be reverted to a stable pluripotent state by the ectopic expression of only four proteins. The resulting pluripotent cells, called induced pluripotent stem (iPS) cells, could be an alternative to embryonic stem cells, which are under continuous ethical debate. Hence, iPS cell-derived functional cells such as neurons may become the key for an effective treatment of currently incurable degenerative diseases. However, besides the requirement of efficacy testing of the therapy also its long-term safety needs to be carefully evaluated in settings mirroring the clinical situation in an optimal way. In this context, we chose the long-lived common marmoset monkey (Callithrix jacchus) as a non-human primate species to generate iPS cells. The marmoset monkey is frequently used in biomedical research and is gaining more and more preclinical relevance due to the increasing number of disease models. Here, we describe, to our knowledge, the first-time generation of marmoset monkey iPS cells from postnatal skin fibroblasts by non-viral means. We used the transposon-based, fully reversible piggyback system. We cloned the marmoset monkey reprogramming factors and established robust and reproducible reprogramming protocols with a six-factor-in-one-construct approach. We generated six individual iPS cell lines and characterized them in comparison with marmoset monkey embryonic stem cells. The generated iPS cells are morphologically indistinguishable from marmoset ES cells. The iPS cells are fully reprogrammed as demonstrated by differentiation assays, pluripotency marker expression and transcriptome analysis. They are stable for numerous passages (more than 80) and exhibit euploidy. In summary, we have established efficient non-viral reprogramming protocols for the derivation of stable marmoset monkey iPS cells, which can be used to develop and test cell replacement therapies in

Non-viral generation of marmoset monkey iPS cells by a six-factor-in-one-vector approach.

Directory of Open Access Journals (Sweden)

Katharina Debowski

Full Text Available Groundbreaking studies showed that differentiated somatic cells of mouse and human origin could be reverted to a stable pluripotent state by the ectopic expression of only four proteins. The resulting pluripotent cells, called induced pluripotent stem (iPS cells, could be an alternative to embryonic stem cells, which are under continuous ethical debate. Hence, iPS cell-derived functional cells such as neurons may become the key for an effective treatment of currently incurable degenerative diseases. However, besides the requirement of efficacy testing of the therapy also its long-term safety needs to be carefully evaluated in settings mirroring the clinical situation in an optimal way. In this context, we chose the long-lived common marmoset monkey (Callithrix jacchus as a non-human primate species to generate iPS cells. The marmoset monkey is frequently used in biomedical research and is gaining more and more preclinical relevance due to the increasing number of disease models. Here, we describe, to our knowledge, the first-time generation of marmoset monkey iPS cells from postnatal skin fibroblasts by non-viral means. We used the transposon-based, fully reversible piggyback system. We cloned the marmoset monkey reprogramming factors and established robust and reproducible reprogramming protocols with a six-factor-in-one-construct approach. We generated six individual iPS cell lines and characterized them in comparison with marmoset monkey embryonic stem cells. The generated iPS cells are morphologically indistinguishable from marmoset ES cells. The iPS cells are fully reprogrammed as demonstrated by differentiation assays, pluripotency marker expression and transcriptome analysis. They are stable for numerous passages (more than 80 and exhibit euploidy. In summary, we have established efficient non-viral reprogramming protocols for the derivation of stable marmoset monkey iPS cells, which can be used to develop and test cell replacement

Testing R&D-Based Endogenous Growth Models

DEFF Research Database (Denmark)

Kruse-Andersen, Peter Kjær

2017-01-01

R&D-based growth models are tested using US data for the period 1953-2014. A general growth model is developed which nests the model varieties of interest. The model implies a cointegrating relationship between multifactor productivity, research intensity, and employment. This relationship...... is estimated using cointegrated VAR models. The results provide evidence against the widely used fully endogenous variety and in favor of the semi-endogenous variety. Forecasts based on the empirical estimates suggest that the slowdown in US productivity growth will continue. Particularly, the annual long...

Dopamine D2-receptor SPECT with [123I]-iodobenzamide in the diagnosis of Parkinson's syndrome

International Nuclear Information System (INIS)

Reiche, W.; Grundmann, M.; Huber, G.

1995-01-01

The purpose of this study was to determine the value of the [ 123 I]IBZM D 2 -receptor SPECT in the differential diagnosis of PS. A total of 38 patients (20 females, 18 males; age 61 ± 13.3 years), with typical extrapyramidal symptoms were investigated. Twenty suffered from idiopathic and 11 from secondary PS. Seven patients in whom a neurological disease could be excluded, served as controls. SPECT data were acquired 90 min after i.v. injection of 185-200 MBq [ 123 I]IBZM. After reconstruction with a Butterworth filter (cutoff frequency 0.5) and attenuation correction (coefficient 0.12 cm -1 ) we quantify the IBZM basal ganglia uptake as ratio to the frontal D 2 -receptor-free cortex (BG/FC). The patients with idiopathic PS (IPS) and the controls revealed high and specific IBZM uptake in the basal ganglia compared to the adjacent frontal brain tissue (IPS: BG/FC = 1,44 ± 0,10; controls: BG/FC = 1.48 ± 0.10). A significant decreased striatal IBZM uptake is found in cases with secondary PS (BG/FC = 1.25 ± 0.10, t-test compared to controls and IPS). The patient group with IPS can be subdivided into patients without L-dopatherapy (BG/FC = 1.49 ± 0.07), patients with longstanding L-dopa-therapy demonstrating significantly decreased striatal IBZM uptake (BG/FC = 1.31 ± 0.04, t-test compared to controls and other IPS), which correlates pathophysiological with a reduction of free D 2 receptors, and patients with de novo PS showing a slight increased striatal IBZM uptake (BG/FC = 1.56 ± 0.05), which represents D 2 -receptor stimulation. [ 123 I]IBZM-SPECT is a sensitive and non-invasive test for striatal D 2 -receptor density and activity which permits relatively clear discrimination between idiopathic and secondary PS and yields important information for differential therapy. (orig.) [de

DNA-binding proteins regulating pIP501 transfer and replication

Directory of Open Access Journals (Sweden)

Elisabeth Grohmann

2016-08-01

Full Text Available pIP501 is a Gram-positive broad-host-range model plasmid intensively used for studying plasmid replication and conjugative transfer. It is a multiple antibiotic resistance plasmid frequently found in clinical Enterococcus faecalis and Enterococcus faecium isolates. Replication of pIP501 proceeds unidirectionally by a theta mechanism. The minimal replicon of pIP501 is composed of the repR gene encoding the essential rate-limiting replication initiator protein RepR and the origin of replication, oriR, located downstream of repR. RepR is similar to RepE of related streptococcal plasmid pAMβ1, which has been shown to possess RNase activity cleaving free RNA molecules in close proximity of the initiation site of DNA synthesis. Replication of pIP501 is controlled by the concerted action of a small protein, CopR, and an antisense RNA, RNAIII. CopR has a dual role: It acts as transcriptional repressor at the repR promoter and prevents convergent transcription of RNAIII and repR mRNA (RNAII, thereby indirectly increasing RNAIII synthesis. CopR binds asymmetrically as a dimer at two consecutive binding sites upstream of and overlapping with the repR promoter. RNAIII induces transcriptional attenuation within the leader region of the repR mRNA (RNAII. Deletion of either control component causes a 10- to 20-fold increase of plasmid copy number, while simultaneous deletions have no additional effect. Conjugative transfer of pIP501 depends on a type IV secretion system (T4SS encoded in a single operon. Its transfer host-range is considerably broad, as it has been transferred to virtually all Gram-positive bacteria including filamentous streptomycetes and even the Gram-negative Escherichia coli. Expression of the 15 genes encoding the T4SS is tightly controlled by binding of the relaxase TraA, the transfer initiator protein, to the operon promoter, which overlaps with the origin of transfer (oriT. The T4SS operon encodes the DNA-binding proteins TraJ (VirD4

iTAR: a web server for identifying target genes of transcription factors using ChIP-seq or ChIP-chip data.

Science.gov (United States)

Yang, Chia-Chun; Andrews, Erik H; Chen, Min-Hsuan; Wang, Wan-Yu; Chen, Jeremy J W; Gerstein, Mark; Liu, Chun-Chi; Cheng, Chao

2016-08-12

Chromatin immunoprecipitation followed by massively parallel DNA sequencing (ChIP-seq) or microarray hybridization (ChIP-chip) has been widely used to determine the genomic occupation of transcription factors (TFs). We have previously developed a probabilistic method, called TIP (Target Identification from Profiles), to identify TF target genes using ChIP-seq/ChIP-chip data. To achieve high specificity, TIP applies a conservative method to estimate significance of target genes, with the trade-off being a relatively low sensitivity of target gene identification compared to other methods. Additionally, TIP's output does not render binding-peak locations or intensity, information highly useful for visualization and general experimental biological use, while the variability of ChIP-seq/ChIP-chip file formats has made input into TIP more difficult than desired. To improve upon these facets, here we present are fined TIP with key extensions. First, it implements a Gaussian mixture model for p-value estimation, increasing target gene identification sensitivity and more accurately capturing the shape of TF binding profile distributions. Second, it enables the incorporation of TF binding-peak data by identifying their locations in significant target gene promoter regions and quantifies their strengths. Finally, for full ease of implementation we have incorporated it into a web server ( http://syslab3.nchu.edu.tw/iTAR/ ) that enables flexibility of input file format, can be used across multiple species and genome assembly versions, and is freely available for public use. The web server additionally performs GO enrichment analysis for the identified target genes to reveal the potential function of the corresponding TF. The iTAR web server provides a user-friendly interface and supports target gene identification in seven species, ranging from yeast to human. To facilitate investigating the quality of ChIP-seq/ChIP-chip data, the web server generates the chart of the

ITT - Fonds d'activités du BRA : l'IPS | CRDI - Centre de recherches ...

International Development Research Centre (IDRC) Digital Library (Canada)

Cette subvention permettra à l'Institute of Policy Studies (IPS) du Sri Lanka, bénéficiaire de l'Initiative Think Tank, de réaliser des recherches de qualité, axées sur les politiques, sur la migration économique. La recherche sera centrée sur des questions soulevées par la National Human Resources and Employment Policy ...

Enhanced service zone architecture for multiservices over IP

Science.gov (United States)

Michaely, Boaz; Mohan, Seshadri

2001-07-01

Recently, the field of IP Telephony has been experienced considerable evolution through the specification of new protocols and introduction of products implementing these protocols. We visualize IP Telephony evolving to soon offer multiservices encompassing not only voice, but also data, video and multimedia. While the progress has focused on refining protocols and architectures, very little attention has been given to business models for offering these services. This paper introduces the concept of a Service Zone, which from a service provider/network operator perspective fits within the operator's administrative domain, but is viewed as an independent zone with its own management and services, requiring minimal integration with the core network services. Besides its own management, the Enhanced Services Zone may also provide provisioning and maintenance features needed to provide the customer services and availability that subscribers expect from a telephony service providers. The platform must provide reliable service over time, be scalable to meet increased capacity demands, and be upgradeable to incorporate advanced services and features as they become available. Signaling flows are illustrated using SIP and H.323.

The ChIP-Seq tools and web server: a resource for analyzing ChIP-seq and other types of genomic data.

Science.gov (United States)

Ambrosini, Giovanna; Dreos, René; Kumar, Sunil; Bucher, Philipp

2016-11-18

ChIP-seq and related high-throughput chromatin profilig assays generate ever increasing volumes of highly valuable biological data. To make sense out of it, biologists need versatile, efficient and user-friendly tools for access, visualization and itegrative analysis of such data. Here we present the ChIP-Seq command line tools and web server, implementing basic algorithms for ChIP-seq data analysis starting with a read alignment file. The tools are optimized for memory-efficiency and speed thus allowing for processing of large data volumes on inexpensive hardware. The web interface provides access to a large database of public data. The ChIP-Seq tools have a modular and interoperable design in that the output from one application can serve as input to another one. Complex and innovative tasks can thus be achieved by running several tools in a cascade. The various ChIP-Seq command line tools and web services either complement or compare favorably to related bioinformatics resources in terms of computational efficiency, ease of access to public data and interoperability with other web-based tools. The ChIP-Seq server is accessible at http://ccg.vital-it.ch/chipseq/ .

The response of Dendroctonus valens (Coleoptera: Scolytidae) and Temnochila chlorodia (Coleoptera: Trogossitidae) to Ips paraconfusus (Coleoptera: Scolytidae) pheromone components and verbenone

Science.gov (United States)

Christopher J. Fettig; Stepehen R. McKelvey; Christopher P. Dabney; Robert R. Borys

2007-01-01

The red turpentine beetle, Dendroctonus valens LeConte, 1860 (Coleoptera: Curculionidae, Scolytinae), is a common bark beetle species found throughout much of North America and China. In 2004, we observed that California fivespined ips, Ips paraconfusus Lanier, 1970 (Coleoptera: Curculionidae, Scolytinae), attack densities in logging debris were inversely related to D...

In Silico Pooling of ChIP-seq Control Experiments

Science.gov (United States)

Sun, Guannan; Srinivasan, Rajini; Lopez-Anido, Camila; Hung, Holly A.; Svaren, John; Keleş, Sündüz

2014-01-01

As next generation sequencing technologies are becoming more economical, large-scale ChIP-seq studies are enabling the investigation of the roles of transcription factor binding and epigenome on phenotypic variation. Studying such variation requires individual level ChIP-seq experiments. Standard designs for ChIP-seq experiments employ a paired control per ChIP-seq sample. Genomic coverage for control experiments is often sacrificed to increase the resources for ChIP samples. However, the quality of ChIP-enriched regions identifiable from a ChIP-seq experiment depends on the quality and the coverage of the control experiments. Insufficient coverage leads to loss of power in detecting enrichment. We investigate the effect of in silico pooling of control samples within multiple biological replicates, multiple treatment conditions, and multiple cell lines and tissues across multiple datasets with varying levels of genomic coverage. Our computational studies suggest guidelines for performing in silico pooling of control experiments. Using vast amounts of ENCODE data, we show that pairwise correlations between control samples originating from multiple biological replicates, treatments, and cell lines/tissues can be grouped into two classes representing whether or not in silico pooling leads to power gain in detecting enrichment between the ChIP and the control samples. Our findings have important implications for multiplexing samples. PMID:25380244

Does Vitamin D Supplementation Enhance Musculoskeletal Performance in Individuals Identified as Vitamin D Deficient through Blood Spot Testing?

Science.gov (United States)

Murphy, Kellie A.

This thesis investigated possible changes in performance after one month of vitamin D supplementation in individuals found to be vitamin D deficient or insufficient through blood spot testing. Thirty-two males, ages 18-32, participated. Each subject visited the lab three times in one-month, completing four performance tests each session, including an isometric mid-thigh pull and a vertical jump on a force plate, a isometric 90-degree elbow flexion test using a load cell, and a psychomotor vigilance test on a palm pilot. The initial lab included blood spot tests to find vitamin D levels. In a single blind manner, 16 subjects were assigned vitamin D and 16 the placebo. Repeated measures ANOVA analysis did not reveal any main effects for time (F=2.626, p=0.364), treatment (vitamin D3 vs placebo; F=1.282, p=0.999), or interaction effects for treatment by time (F=0.304, p=0.999) for maximum force production during an isometric mid-thigh pull. Repeated measures ANOVA analysis did not reveal any main effects for time (F=1.323, p=0.999), treatment (vitamin D3 vs placebo; F=0.510, p=0.999), or interaction effects for treatment by time (F= 1.625, p=0.860) for rate of force production during a vertical jump. Repeated measures ANOVA analysis did not reveal any main effects for time (F=0.194, p=0.999), treatment (vitamin D3 vs placebo; F=2.452, p=0.513), or interaction effects for treatment by time (F= 1.179, p=0.999) for maximal force production during a 90-degree isometric elbow flexion. Repeated measures ANOVA analysis did not reveal any main effects for time (F=1.710, p=0.804), treatment (vitamin D3 vs placebo; F=1.471, p=0.94), or interaction effects for treatment by time (F= 0.293, p=0.999) for mean reaction time to random stimuli during the psychomotor vigilance test. Repeated measures ANOVA analysis did not reveal any main effects for time (F=0.530, p=0.999), treatment (vitamin D3 vs placebo; F=0.141, p=0.999), or interaction effects for treatment by time (F=0.784 p=0

Security of IP Telephony in Ecuador: Online Analysis

Directory of Open Access Journals (Sweden)

José Estrada

2016-06-01

Full Text Available Telephony is a global service and thus telephone networks have been a coveted target for criminals. Now that voice can be transported over IP and that multiple services are integrated in a convergent model through Internet, there are more incentives to attack and more attackers. Moreover, the development of open source telephone applications has encouraged the massive use of IP telephony, but not an increased awareness about embedded security risks. Due to the current and intensive adoption of IP telephony systems in Ecuador, we conducted an exploration based on public information to obtain statistics about telephone systems connected to Internet in Ecuador. Additionally, using a deliberately vulnerable IP telephony system, we collected more data to do a preliminary analysis of threats to such systems. We found that hundreds of telephone systems were publicly available on the Internet and using outdated versions of Asterisk-based applications. We also found thousands of malicious interactions on the IP telephony system we deployed on the Internet.

Presence in the IP Multimedia Subsystem

Directory of Open Access Journals (Sweden)

Ling Lin

2007-01-01

Full Text Available With an ever increasing penetration of Internet Protocol (IP technologies, the wireless industry is evolving the mobile core network towards all-IP network. The IP Multimedia Subsystem (IMS is a standardised Next Generation Network (NGN architectural framework defined by the 3rd Generation Partnership Project (3GPP to bridge the gap between circuit-switched and packet-switched networks and consolidate both sides into on single all-IP network for all services. In this paper, we provide an insight into the limitation of the presence service, one of the fundamental building blocks of the IMS. Our prototype-based study is unique of its kind and helps identifying the factors which limit the scalability of the current version of the presence service (3GPP TS 23.141 version 7.2.0 Release 7 [1], which will in turn dramatically limit the performance of advanced IMS services. We argue that the client-server paradigm behind the current IMS architecture does not suite the requirements of the IMS system, which defies the very purpose of its introduction. We finally elaborate on possible avenues for addressing this problem.

On-line Monitoring of VoIP Quality Using IPFIX

Directory of Open Access Journals (Sweden)

Petr Matousek

2014-01-01

Full Text Available The main goal of VoIP services is to provide a reliable and high-quality voice transmission over packet networks. In order to prove the quality of VoIP transmission, several approaches were designed. In our approach, we are concerned about on-line monitoring of RTP and RTCP traffic. Based on these data, we are able to compute main VoIP quality metrics including jitter, delay, packet loss, and finally R-factor and MOS values. This technique of VoIP quality measuring can be directly incorporated into IPFIX monitoring framework where an IPFIX probe analyses RTP/RTCP packets, computes VoIP quality metrics, and adds these metrics into extended IPFIX flow records. Then, these extended data are stored in a central IPFIX monitoring system called collector where can be used for monitoring purposes. This paper presents a functional implementation of IPFIX plugin for VoIP quality measurement and compares the results with results obtained by other tools.

NMDA receptor antagonists inhibit catalepsy induced by either dopamine D1 or D2 receptor antagonists.

Science.gov (United States)

Moore, N A; Blackman, A; Awere, S; Leander, J D

1993-06-11

In the present study, we investigated the ability of NMDA receptor antagonists to inhibit catalepsy induced by haloperidol, or SCH23390 and clebopride, selective dopamine D1 and D2 receptor antagonists respectively. Catalepsy was measured by recording the time the animal remained with its forepaws placed over a rod 6 cm above the bench. Pretreatment with either the non-competitive NMDA receptor antagonist, MK-801 (0.25-0.5 mg/kg i.p.) or the competitive antagonist, LY274614 (10-20 mg/kg i.p.) reduced the cataleptic response produced by haloperidol (10 mg/kg), SCH23390 (2.5-10 mg/kp i.p.) or clebopride (5-20 mg/kg i.p.). This demonstrates that NMDA receptor antagonists will reduce both dopamine D1 and D2 receptor antagonist-induced catalepsy. Muscle relaxant doses of chlordiazepoxide (10 mg/kg i.p.) failed to reduce the catalepsy induced by haloperidol, suggesting that the anticataleptic effect of the NMDA receptor antagonists was not due to a non-specific action. These results support the hypothesis that NMDA receptor antagonists may have beneficial effects in disorders involving reduced dopaminergic function, such as Parkinson's disease.

Immunocytochemical evidence for co-expression of Type III IP3 receptor with signaling components of bitter taste transduction

Directory of Open Access Journals (Sweden)

Kinnamon Sue C

2001-04-01

Full Text Available Abstract Background Taste receptor cells are responsible for transducing chemical stimuli into electrical signals that lead to the sense of taste. An important second messenger in taste transduction is IP3, which is involved in both bitter and sweet transduction pathways. Several components of the bitter transduction pathway have been identified, including the T2R/TRB taste receptors, phospholipase C β2, and the G protein subunits α-gustducin, β3, and γ13. However, the identity of the IP3 receptor subtype in this pathway is not known. In the present study we used immunocytochemistry on rodent taste tissue to identify the IP3 receptors expressed in taste cells and to examine taste bud expression patterns for IP3R3. Results Antibodies against Type I, II, and III IP3 receptors were tested on sections of rat and mouse circumvallate papillae. Robust cytoplasmic labeling for the Type III IP3 receptor (IP3R3 was found in a large subset of taste cells in both species. In contrast, little or no immunoreactivity was seen with antibodies against the Type I or Type II IP3 receptors. To investigate the potential role of IP3R3 in bitter taste transduction, we used double-label immunocytochemistry to determine whether IP3R3 is expressed in the same subset of cells expressing other bitter signaling components. IP3R3 immunoreactive taste cells were also immunoreactive for PLCβ2 and γ13. Alpha-gustducin immunoreactivity was present in a subset of IP3R3, PLCβ2, and γ13 positive cells. Conclusions IP3R3 is the dominant form of the IP3 receptor expressed in taste cells and our data suggest it plays an important role in bitter taste transduction.

GSM SiNYALLERİNİN .IP OMURGASI İİZERiNI>E TAŞINMASI (SS7 OVER IP- NettcSS7)

OpenAIRE

Tülü, Çağatay Neftali; Demirkol, Aşkın

2003-01-01

Bu çalışmada günümüzün en popüler nıobilhaberleşme sistemi olan GSM [1 l sisteminin, kendiöğeleri aras1ndaki en temel sinyalleşme sistemi olannumara 7 (SS7 [2) ) sinyallerinin, günümüzün enyaygın iletim omurgast olan ve tüm dünyadakibilgisayarları birbirine bağlayan IP (3] omurgasıüzerinden taşınabilmesi için gerekli si stemin tasar11n1ve gerçeklenınesi üzerinde çahş1lmtştır. Klasil\\ SS7iletimine göre en büyül< faydası çok düşül{ maliyetiolan bu sistem sayesinde, dünyadaki b i r çok GS...

Mobility management in mobile IP

Science.gov (United States)

Medidi, Sirisha; Golshani, Forouzan

2002-07-01

There is an emerging interest in integrating mobile wireless communication with the Internet based on the Ipv6 technology. Many issues introduced by the mobility of users arise when such an integration is attempted. This paper addresses the problem of mobility management, i.e., that of tracking the current IP addresses of mobile terminals and sustaining active IP connections as mobiles move. The paper presents some architectural and mobility management options for integrating wireless access to the Internet. We then present performance results for Mobile IPv4, route optimization and Mobile IPv6.

Capturing value from Intellectual Property (IP) in a global environment

DEFF Research Database (Denmark)

Alcácer, Juan; Beukel, Karin; Cassiman, Bruno

2017-01-01

Globalization should provide firms with an opportunity to leverage their know-how and reputation across countries to create value. However, it remains challenging for them to actually capture that value using traditional Intellectual Property (IP) tools. In this paper, we document the strong growth...... in patents, trademarks, and industrial designs used by firms to protect their IP globally. We then show that IP protection remains fragmented; the quality of IP applications might be questionable; and developing a comprehensive IP footprint worldwide is very costly. Growing numbers of applications...

Content-Adaptive Packetization and Streaming of Wavelet Video over IP Networks

Directory of Open Access Journals (Sweden)

Chien-Peng Ho

2007-03-01

Full Text Available This paper presents a framework of content-adaptive packetization scheme for streaming of 3D wavelet-based video content over lossy IP networks. The tradeoff between rate and distortion is controlled by jointly adapting scalable source coding rate and level of forward error correction (FEC protection. A content dependent packetization mechanism with data-interleaving and Reed-Solomon protection for wavelet-based video codecs is proposed to provide unequal error protection. This paper also tries to answer an important question for scalable video streaming systems: given extra bandwidth, should one increase the level of channel protection for the most important packets, or transmit more scalable source data? Experimental results show that the proposed framework achieves good balance between quality of the received video and level of error protection under bandwidth-varying lossy IP networks.

Isotope Production and Distribution Program. Financial statements, September 30, 1994 and 1993

Energy Technology Data Exchange (ETDEWEB)

Marwick, P.

1994-11-30

The attached report presents the results of the independent certified public accountants` audit of the Isotope Production and Distribution (IP&D) Program`s financial statements as of September 30, 1994. The auditors have expressed an unqualified opinion on IP&D`s 1994 statements. Their reports on IP&D`s internal control structure and on compliance with laws,and regulations are also provided. The charter of the Isotope Program covers the production and sale of radioactive and stable isotopes, byproducts, and related isotope services. Prior to October 1, 1989, the Program was subsidized by the Department of Energy through a combination of appropriated funds and isotope sales revenue. The Fiscal Year 1990 Appropriations Act, Public Law 101-101, authorized a separate Isotope Revolving Fund account for the Program, which was to support itself solely from the proceeds of isotope sales. The initial capitalization was about $16 million plus the value of the isotope assets in inventory or on loan for research and the unexpended appropriation available at the close of FY 1989. During late FY 1994, Public Law 103--316 restructured the Program to provide for supplemental appropriations to cover costs which are impractical to incorporate into the selling price of isotopes. Additional information about the Program is provided in the notes to the financial statements.

Using VoIP to compete.

Science.gov (United States)

Werbach, Kevin

2005-09-01

Internet telephony, or VoIP, is rapidly replacing the conventional kind. This year, for the first time, U.S. companies bought more new Internet-phone connections than standard lines. The major driver behind this change is cost. But VoIP isn't just a new technology for making old-fashioned calls cheaper, says consultant Kevin Werbach. It is fundamentally changing how companies use voice communications. What makes VoIP so powerful is that it turns voice into digital data packets that can be stored, copied, combined with other data, and distributed to virtually any device that connects to the Internet. And it makes it simple to provide all the functionality of a corporate phone-call features, directories, security-to anyone anywhere there's broadband access. That fosters new kinds of businesses such as virtual call centers, where widely dispersed agents work at all hours from their homes. The most successful early adopters, says Werbach, will focus more on achieving business objectives than on saving money. They will also consider how to push VoIP capabilities out to the extended organization, making use of everyone as a resource. Deployment may be incremental, but companies should be thinking about where VoIP could take them. Executives should ask what they could do if, on demand, they could bring all their employees, customers, suppliers, and partners together in a virtual room, with shared access to every modern communications and computing channel. They should take a fresh look at their business processes to find points at which richer and more customizable communications could eliminate bottlenecks and enhance quality. The important dividing line won't be between those who deploy Vol P and those who don't, or even between early adopters and laggards. It will be between those who see Vol P as just a new way to do the same old things and those who use itto rethink their entire businesses.

Study of transmitting electric power utility communications in IP network. Transmission of existing electric power utility communications in best effort type IP network under delay constraint; Denryokuyo tsushin kaisen no IP mo eno shuyo kento. Chien jikan seiyakuka ni okeru best effort gata IP mo eno kison denryokuyo tsushin kaisen no shuyo

Energy Technology Data Exchange (ETDEWEB)

Miyake, H.

2000-07-01

Since IP network does best effort behavior fundamentally, it always generates delay time and delay variation. For this reason, IP network has been unsuitable to transmit real time data such as a voice. However, in recent years, the technologies which transmit real time data in IP network, e.g. VoIP, have spread. If it is possible to transmit the existing electric power utility communications in IP network using these technologies, total network cost can be reduced by the reduction of required bandwidth and the simplification of communication network systems. In this report, it is examined quantitatively whether end-end delay time of the existing electric power utility communications, e.g. on-line, telephone, carrier relay, CDT (cyclic digital transmission equipment), video conference, ITV(industrial television), is within their permission delay time when they are transmitted in the best effort type IP network. (author)

Enabling new e-health business models by converging IP-based and non-IP-based home networks

OpenAIRE

Hartog, F.T.H. den; Tijmes, M.R.; Cramer, E.R.; Noorbergen, A.

2013-01-01

Current efforts in extending the Internet are focused on achieving full support of services and user-centric content from sectors such as energy management, education, and e-health. Until recently, these sectors typically developed their own communication infrastructure and systems, leading to point solutions, often built on non-IP technologies. We describe a demonstrator that shows how a non-IP supporting Continua-certified health device, such as a weighing scale, can be unlocked for use by ...

A TCP/IP transport layer for the DAQ of the CMS experiment

International Nuclear Information System (INIS)

Kozlovszky, M.

2004-01-01

The CMS collaboration is currently investigating various networking technologies that may meet the requirements of the CMS Data Acquisition System (DAQ). During this study, a peer transport component based on TCP/IP has been developed using object-oriented techniques for the distributed DAQ framework named XDAQ. This framework has been designed to facilitate the development of distributed data acquisition systems within the CMS Experiment. The peer transport component has to meet 3 main requirements. Firstly, it had to provide fair access to the communication medium for competing applications. Secondly, it had to provide as much of the available bandwidth to the application layer as possible. Finally, it had to hide the complexity of using non-blocking TCP/IP connections from the application layer. This paper describes the development of the peer transport component and then presents and draws conclusions on the measurements made during tests. The major topics investigated include: blocking versus non-blocking communication, TCP/IP configuration options, multi-rail connections

Analysis of Morphogenic Effect of hDAB2IP on Prostate Cancer and its Disease Correlation

Science.gov (United States)

2005-02-01

Ezh2 protein became more prominent 96 hrs RESULTS after transfection. Under this condition , Profiling hDAB2IP and Ezh2 the elevated levels of hDAB2IP...Pirrotta, V., Poux, S., Melfi, R., S., Vessella, R., Lin, D. L., and Pilyugin, M. (2003) Genetica Pienta, K. J. (2001) In Vivo. 15, 117:191-197 163-168...performed using iCycler machine (Bio-Rad) and the reaction condition was as follow: 95’C (3 min) and 40 cycles amplification cycle (95 0C [30 sec], 55°C

25-hydroxy vitamin D test

Science.gov (United States)

25-OH vitamin D test; Calcidiol; 25-hydroxycholecalciferol test ... follow any instructions for not eating before the test. ... This test is done to determine if you have too much or too little vitamin D in your blood.

Energy star compliant voice over internet protocol (VoIP) telecommunications network including energy star compliant VoIP devices

Science.gov (United States)

Kouchri, Farrokh Mohammadzadeh

2012-11-06

A Voice over Internet Protocol (VoIP) communications system, a method of managing a communications network in such a system and a program product therefore. The system/network includes an ENERGY STAR (E-star) aware softswitch and E-star compliant communications devices at system endpoints. The E-star aware softswitch allows E-star compliant communications devices to enter and remain in power saving mode. The E-star aware softswitch spools messages and forwards only selected messages (e.g., calls) to the devices in power saving mode. When the E-star compliant communications devices exit power saving mode, the E-star aware softswitch forwards spooled messages.

Fracture strength of three all-ceramic systems: Top-Ceram compared with IPS-Empress and In-Ceram.

Science.gov (United States)

Quran, Firas Al; Haj-Ali, Reem

2012-03-01

The purpose of this study was to investigate the fracture loads and mode of failure of all-ceramic crowns fabricated using Top-Ceram and compare it with all-ceramic crowns fabricated from well-established systems: IPS-Empress II, In-Ceram. Thirty all-ceramic crowns were fabricated; 10 IPS-Empress II, 10 In-Ceram alumina and 10 Top-Ceram. Instron testing machine was used to measure the loads required to introduce fracture of each crown. Mean fracture load for In-Ceram alumina [941.8 (± 221.66) N] was significantly (p > 0.05) higher than those of Top-Ceram and IPS-Empress II. There was no statistically significant difference between Top-Ceram and IPS-Empress II mean fracture loads; 696.20 (+222.20) and 534 (+110.84) N respectively. Core fracture pattern was highest seen in Top- Ceram specimens.

3D and 2D marginal fit of pressed and CAD/CAM lithium disilicate crowns made from digital and conventional impressions.

Science.gov (United States)

Anadioti, Evanthia; Aquilino, Steven A; Gratton, David G; Holloway, Julie A; Denry, Isabelle; Thomas, Geb W; Qian, Fang

2014-12-01

This in vitro study evaluated the 3D and 2D marginal fit of pressed and computer-aided-designed/computer-aided-manufactured (CAD/CAM) all-ceramic crowns made from digital and conventional impressions. A dentoform tooth (#30) was prepared for an all-ceramic crown (master die). Thirty type IV definitive casts were made from 30 polyvinyl siloxane (PVS) impressions. Thirty resin models were produced from thirty Lava Chairside Oral Scanner impressions. Thirty crowns were pressed in lithium disilicate (IPS e.max Press; 15/impression technique). Thirty crowns were milled from lithium disilicate blocks (IPS e.max CAD; 15/impression technique) using the E4D scanner and milling engine. The master die and the intaglio of the crowns were digitized using a 3D laser coordinate measurement machine with accuracy of ±0.00898 mm. For each specimen a separate data set was created for the Qualify 2012 software. The digital master die and the digital intaglio of each crown were merged using best-fitting alignment. An area above the margin with 0.75 mm occlusal-gingival width circumferentially was defined. The 3D marginal fit of each specimen was an average of all 3D gap values on that area. For the 2D measurements, the marginal gap was measured at two standardized points (on the margin and at 0.75 mm above the margin), from standardized facial-lingual and mesial-distal digitized sections. One-way ANOVA with post hoc Tukey's honestly significant difference and two-way ANOVA tests were used, separately, for statistical analysis of the 3D and 2D marginal data (alpha = 0.05). One-way ANOVA revealed that both 3D and 2D mean marginal gap for group A: PVS impression/IPS e.max Press (0.048 mm ± 0.009 and 0.040 mm ± 0.009) were significantly smaller than those obtained from the other three groups (p max CAD (0.088 mm ± 0.024 and 0.076 mm ± 0.023), C: digital impression/IPS e.max Press (0.089 mm ± 0.020 and 0.075 mm ± 0.015) and D: digital impression/IPS e.max CAD (0.084 mm ± 0.021 and 0

Isolation, pointing, and suppression (IPS) system for high-performance spacecraft

Science.gov (United States)

Hindle, Tim; Davis, Torey; Fischer, Jim

2007-04-01

Passive mechanical isolation is often times the first step taken to remedy vibration issues on-board a spacecraft. In many cases, this is done with a hexapod of axial members or struts to obtain the desired passive isolation in all six degrees-of-freedom (DOF). In some instances, where the disturbance sources are excessive or the payload is particularly sensitive to vibration, additional steps are taken to improve the performance beyond that of passive isolation. Additional performance or functionality can be obtained with the addition of active control, using a hexapod of hybrid (passive/active) elements at the interface between the payload and the bus. This paper describes Honeywell's Isolation, Pointing, and Suppression (IPS) system. It is a hybrid isolation system designed to isolate a sensitive spacecraft payload with very low passive resonant break frequencies while affording agile independent payload pointing, on-board payload disturbance rejection, and active isolation augmentation. This system is an extension of the work done on Honeywell's previous Vibration Isolation, Steering, and Suppression (VISS) flight experiment. Besides being designed for a different size payload than VISS, the IPS strut includes a dual-stage voice coil design for improved dynamic range as well as improved low-noise drive electronics. In addition, the IPS struts include integral load cells, gap sensors, and payloadside accelerometers for control and telemetry purposes. The associated system-level control architecture to accomplish these tasks is also new for this program as compared to VISS. A summary of the IPS system, including analysis and hardware design, build, and single axis bipod testing will be reviewed.

Heterogeneous IP Ecosystem enabling Reuse (HIER)

Science.gov (United States)

2017-03-22

HIER project, DARPA also established additional concepts in the formation of the Common Heterogeneous Integration and IP Reuse Strategies (CHIPS...would need a major change to  business model to offer  Hard  or Soft IP – So CHIPS program can be a better fit to these firms • DoD‐Contractor IP pricing

Local Duck Fanning At Paddy Three Times Planting Areas ("IP Padi 300"

Directory of Open Access Journals (Sweden)

Setioko A.R

2000-03-01

Full Text Available Most of duck husbandry in Indonesia is still run traditionally, herded in rice field or in the swampy area. This kind of husbandry seemed to be much preferred by farmers as they thought it was a simple and did not need high skill and high capital "IP padi 300" was a term of rice planting system tree times instead of twice in a year. This kind of changing might have significantly affected duck faming. The objective of the study was to observe the interactively effect of "IP padi 300" to duck husbandry at the same area. Two locations were choosen (Subang, West Jawa and Pemalang, Central Java with 5 farmers at each location to be involved in the study. As many as 1200 laying pullet ducks were distributed to 10 farmers at two locations. The farmers were suggested to raise laying ducks with their own systems (fully intensive, semi intensive and fully herded and were observed for 6 months. Biota was observed on both field and in the crop of the laying ducks. There was an interactive effect of "IP padi 300" and the duck farming on the same area. The availability of feed was increased on the "IP padi 300", which gave benefit to duck farming especially fue herded system, not to go far from owner's home base. Whilst the benefit to "IP padi 300" was assumed to the reduction of pest and desease, which was frequently attacked the rice field. The production of egg from herded duck was very fluctuative due to the movement and feed availability in the rice field. Field biota in Subang and Pemalang was very much the same in profile, although "golden snail" was only found in Subang. Ducks' crop content seemed to be very much similar with the profile of field biota, although rice grain was the most in the crop. Thus, it was found that field biota was not reduced by "IP padi 300", in fact it was rather increased.

Mobile IP: state of the art report

NARCIS (Netherlands)

Karagiannis, Georgios; Heijenk, Geert

Due to roaming, a mobile device may change its network attachment each time it moves to a new link. This might cause a disruption for the Internet data packets that have to reach the mobile node. Mobile IP is a protocol, developed by the Mobile IP Internet Engineering Task Force (IETF) working

Quantitative analysis of macro-ARG using IP system

International Nuclear Information System (INIS)

Nakajima, Eiichi; Kawai, Kenji; Furuta, Yoshitake

1997-01-01

Recent progress in imaging plate (IP) system allow us to analyze autoradiographic images quantitatively. In the 'whole-body autoradiography', a method clarify the distribution of radioisotope or labeled compounds in the tissues and organs in a freeze-dried whole-body section of small animals such as rats and mice, the sections are pressed against a IP for exposure and the IP is scanned by Bio-Imaging Analyzer (Fuji Photo Film Co., Ltd) and a digital autoradiographic image is given. Quantitative data concerning the activity in different tissues can be obtained using an isotope scale as a reference source. Fading effect, application of IP system for distribution of receptor binding ARG, analysis of radio-spots on TLC and radioactive concentration in liquid such as blood are also discussed. (author)

CXCL10/IP10 is a novel potential in vitro marker of TB infection

Directory of Open Access Journals (Sweden)

Ilaria Sauzullo

2009-06-01

Full Text Available Introduction IFN-γ is a pivotal cytokine in the immune response to Myc. tuberculosis, infact this is the key cytokine produced in response to antigens specific following tuberculosis exposure causing either active or latent tuberculosis (TB and this observation forms the basis of interferon gamma release assay (IGRA, but there are alternative or additional cytokines and chemokines that could be used to improve detection of Myc. tuberculosis infection.The aim of this study was to evaluate the diagnostic utility of chemokine CXCL10/IP-10 as biomarker of active TB and to compare the results with classical QuantiFERON-Gold assay . Methods CXCL10/IP-10 and IFN-γ responses to stimulation with ESAT-6 and CFP-10 were evaluated in 21 patients with active tuberculosis and in 6 healthy unexposed subjects with no history of TB or TB contact were used as controls healthy controls. QuantiFERON-TB Gold (QFT-G, Cellestis was used for the measurement of IFN-γ levels; CXCL10/IP-10 was detected by ELISA (R&D Systems . Results Of the 21 TB patients included, 11 had a QFT-G positive and 10 had negative QFT-G results.All QFT-G positive patients had increased levels of CXCL10/IP-10 (median, pg/ml in both ESAT-6 and CFP-10 stimulated samples patients compared to healthy controls (1807 and 1111 vs 251 and 188 of controls, respectively (p<0.001 for both. The patients with active TB and QFT-G negative exhibited higher concentrations of CXCL10/IP-10 following antigen stimulation (837 pg/ml for ESAT-6;1674 pg/ml for CFP-10 (p<0.001. Conclusion Our study showed that in all patients with active TB, the CXCL10/IP-10 is expressed in higher amounts than IFN-γ following Myc. tuberculosis antigen-specific stimulation, and CXCL10/IP-10 appeared to be even more sensitive than QuantiFERON TB-Gold in TB patients with negative IFN-γ response. The measurement of chemokine CXCL10/IP-10, although not specific for tuberculosis, may have potential as an alternative or additional marker

Antidepressant effect of pramipexole in mice forced swimming test: A cross talk between dopamine receptor and NMDA/nitric oxide/cGMP pathway.

Science.gov (United States)

Ostadhadi, Sattar; Imran Khan, Muhammad; Norouzi-Javidan, Abbas; Dehpour, Ahmad-Reza

2016-07-01

Pramipexole is a dopamine D2 receptor agonist indicated for treating Parkinson disorder. This study was aimed to investigate the effect of pramipexole in forced swimming test (FST) in mice and the possible involvement of activation of D2 receptors and inhibition of N-methyl-d-aspartate (NMDA) receptors and nitric oxide-cyclic guanosine monophosphate (NO-cGMP) on this effect. Intraperitoneal administration of pramipexole (1-3mg/kg) reduced the immobility time in the FST similar to fluoxetine (20mg/kg, i.p.). This effect of pramipexole (1mg/kg, i.p.) was ceased when mice were pretreated with haloperidol (0.15mg/kg, i.p,) and sulpiride (5mg/kg, i.p) as D2 receptor antagonists, NMDA (75mg/kg,i.p.), l-arginine (750mg/kg, i.p., a substrate for nitric oxide synthase) or sildenafil (5mg/kg, i.p., a phosphodiesterase 5 inhibitor). The administration of MK-801 (0.05mg/kg, i.p., a NMDA receptor antagonist) l-NG-Nitro arginine methyl ester (l-NAME, 10mg/kg, i.p., a non-specific nitric oxide synthase (NOS) inhibitor), 7-nitroindazole (30mg/kg, i.p., a neuronal NOS inhibitor) and methylene blue (10mg/kg, i.p.), an inhibitor of both NOS and soluble guanylyl cyclase (sGC) in combination with the sub-effective dose of pramipexole (0.3mg/kg, i.p.) reduced the immobility. Altogether, our data suggest that the antidepressant-like effect of pramipexole is dependent on the activation of D2 receptor and inhibition of either NMDA receptors and/or NO-cGMP synthesis. These results contribute to the understanding of the mechanisms underlying the antidepressant-like effect of pramipexole and reinforce the role of D2 receptors, NMDA receptors and l-arginine-NO-GMP pathway in the antidepressant mechanism of this agent. Copyright © 2016. Published by Elsevier Masson SAS.

Internetworking with TCP/IP

CERN Document Server

Comer, Douglas E

2014-01-01

An internationally best-selling, conceptual introduction to the TCP/IP protocols and Internetworking, this book interweaves a clear discussion of fundamentals and scientific principles with details and examples drawn from the latest technologies. Leading author Douglas Comer covers layering and packet formats for all the Internet protocols, includingTCP, IPv4, IPv6, DHCP, and DNS. In addition, the text explains new trends in Internet systems, including packet classification, Software Defined Networking (SDN), and mesh protocols used in The Internet of Things. The text is appropriate for individuals interested in learning more about TCP/IP protocols, Internet architecture, and current networking technologies, as well as engineers who build network systems. It is suitable for junior to graduate-level courses in Computer Networks, Data Networks, Network Protocols, and Internetworking.

Effects of ketamine and N-methyl-D-aspartate on fluoxetine-induced antidepressant-related behavior using the forced swimming test.

Science.gov (United States)

Owolabi, Rotimi Adegbenga; Akanmu, Moses Atanda; Adeyemi, Oluwole Isaac

2014-04-30

This study investigated the effects of ketamine on fluoxetine-induced antidepressant behavior using the forced swimming test (FST) in mice. In order to understand the possible role of N-methyl-d-aspartate (NMDA) neurotransmission in the antidepressant effect of fluoxetine, different groups of mice (n=10) were administered with acute ketamine (3mg/kg, i.p.), acute NMDA (75mg/kg and 150mg/kg, i.p.) and a 21-day chronic ketamine (15mg/kg, i.p./day) were administered prior to the administration of fluoxetine (20mg/kg, i.p.) in the mice. Antidepressant related behavior (immobility score) was measured using the forced swimming test. The results showed that the acute ketamine and fluoxetine alone treatments elicited a significant (pfluoxetine-induced decrease in immobility score. In contrast, pre-treatment with NMDA (150mg/kg) significantly (pfluoxetine-induced decrease in immobility score. On the other hand, chronic administration of ketamine significantly elicited an increase in immobility score as well as reversed the reduction induced by fluoxetine. Similarly, NMDA administration at both 75mg/kg and 150mg/kg increased immobility score in chronically administered ketamine groups. Furthermore, chronic administration of ketamine, followed by NMDA (75mg/kg) and fluoxetine significantly elevated the immobility score when compared with the group that received NMDA and fluoxetine but not chronically treated with ketamine. It can be suggested) that facilitation of NMDA transmission blocked fluoxetine-induced reduction in immobility score, while down-regulation of NMDA transmission is associated with increase in fluoxetine-induced antidepressant-related behavior in mice. Down-regulation of the NMDA transmission is proposed as an essential component of mechanism of suppression of depression related behaviors by fluoxetine. Modulation of NMDA transmission is suggested to be relevant in the mechanism of action of fluoxetine. Copyright © 2014 Elsevier Ireland Ltd. All rights

The wavy Mutation Maps to the Inositol 1,4,5-Trisphosphate 3-Kinase 2 (IP3K2) Gene of Drosophila and Interacts with IP3R to Affect Wing Development.

Science.gov (United States)

Dean, Derek M; Maroja, Luana S; Cottrill, Sarah; Bomkamp, Brent E; Westervelt, Kathleen A; Deitcher, David L

2015-11-27

Inositol 1,4,5-trisphosphate (IP3) regulates a host of biological processes from egg activation to cell death. When IP3-specific receptors (IP3Rs) bind to IP3, they release calcium from the ER into the cytoplasm, triggering a variety of cell type- and developmental stage-specific responses. Alternatively, inositol polyphosphate kinases can phosphorylate IP3; this limits IP3R activation by reducing IP3 levels, and also generates new signaling molecules altogether. These divergent pathways draw from the same IP3 pool yet cause very different cellular responses. Therefore, controlling the relative rates of IP3R activation vs. phosphorylation of IP3 is essential for proper cell functioning. Establishing a model system that sensitively reports the net output of IP3 signaling is crucial for identifying the controlling genes. Here we report that mutant alleles of wavy (wy), a classic locus of the fruit fly Drosophila melanogaster, map to IP3 3-kinase 2 (IP3K2), a member of the inositol polyphosphate kinase gene family. Mutations in wy disrupt wing structure in a highly specific pattern. RNAi experiments using GAL4 and GAL80(ts) indicated that IP3K2 function is required in the wing discs of early pupae for normal wing development. Gradations in the severity of the wy phenotype provide high-resolution readouts of IP3K2 function and of overall IP3 signaling, giving this system strong potential as a model for further study of the IP3 signaling network. In proof of concept, a dominant modifier screen revealed that mutations in IP3R strongly suppress the wy phenotype, suggesting that the wy phenotype results from reduced IP4 levels, and/or excessive IP3R signaling. Copyright © 2016 Dean et al.

The wavy Mutation Maps to the Inositol 1,4,5-Trisphosphate 3-Kinase 2 (IP3K2 Gene of Drosophila and Interacts with IP3R to Affect Wing Development

Directory of Open Access Journals (Sweden)

Derek M. Dean

2016-02-01

Full Text Available Inositol 1,4,5-trisphosphate (IP3 regulates a host of biological processes from egg activation to cell death. When IP3-specific receptors (IP3Rs bind to IP3, they release calcium from the ER into the cytoplasm, triggering a variety of cell type- and developmental stage-specific responses. Alternatively, inositol polyphosphate kinases can phosphorylate IP3; this limits IP3R activation by reducing IP3 levels, and also generates new signaling molecules altogether. These divergent pathways draw from the same IP3 pool yet cause very different cellular responses. Therefore, controlling the relative rates of IP3R activation vs. phosphorylation of IP3 is essential for proper cell functioning. Establishing a model system that sensitively reports the net output of IP3 signaling is crucial for identifying the controlling genes. Here we report that mutant alleles of wavy (wy, a classic locus of the fruit fly Drosophila melanogaster, map to IP3 3-kinase 2 (IP3K2, a member of the inositol polyphosphate kinase gene family. Mutations in wy disrupt wing structure in a highly specific pattern. RNAi experiments using GAL4 and GAL80ts indicated that IP3K2 function is required in the wing discs of early pupae for normal wing development. Gradations in the severity of the wy phenotype provide high-resolution readouts of IP3K2 function and of overall IP3 signaling, giving this system strong potential as a model for further study of the IP3 signaling network. In proof of concept, a dominant modifier screen revealed that mutations in IP3R strongly suppress the wy phenotype, suggesting that the wy phenotype results from reduced IP4 levels, and/or excessive IP3R signaling.

In-situ calibration: migrating control system IP module calibration from the bench to the storage ring

International Nuclear Information System (INIS)

Weber, Jonah M.; Chin, Michael

2002-01-01

The Control System for the Advanced Light Source (ALS) at Lawrence Berkeley National Lab (LBNL) uses in-house designed IndustryPack(registered trademark) (IP) modules contained in compact PCI (cPCI) crates with 16-bit analog I/O to control instrumentation. To make the IP modules interchangeable, each module is calibrated for gain and offset compensation. We initially developed a method of verifying and calibrating the IP modules in a lab bench test environment using a PC with LabVIEW. The subsequent discovery that the ADCs have significant drift characteristics over periods of days of installed operation prompted development of an ''in-situ'' calibration process--one in which the IP modules can be calibrated without removing them from the cPCI crates in the storage ring. This paper discusses the original LabVIEW PC calibration and the migration to the proposed in-situ EPICS control system calibration

PENGARUH PELAKSANAAN MODEL PEMBELAJARAN KOOPERATIF TIPE THINK PAIR SHARE TERHADAP HASIL BELAJAR IPS SISWA

Directory of Open Access Journals (Sweden)

andi fathur asdar

2016-08-01

Full Text Available The objective of this research was to describe: 1 Teacher ability in the implementation of cooperative learning Think Pair Share, 2 Ttudent activities in the implementation of cooperative learning Think Pair Share, 3 Tearning result on IPS before and after the implementation of cooperative learning Think Pair Share, 4 learning result on IPS before and after learning process with lecture method, 5 to find out the influence of the implementation of cooperative learning Think Pair Share toward learning result on IPS. The method used was true experiment with pre-test post-test control group design. The population in the study are 4th grade student at SDN Sungguminasa II Somba Opu District Gowa Regency. Samples used are 40 student 20 student each from experiment and comparing group. chosen by simple random sampling. The data obtained from samples were analyzed with descritive and inferensial statistic. The result shows: 1 teacher ability in the implementation of cooperative learning Think Pair Share have increased, 2 student activities in the implementation of cooperative learning Think Pair Share, 3 student learning result who teached by cooperative learning Think Pair Share have increased, 4 student learning result who teached by lecture method have not increased, 5 the implementation of cooperative learning Think Pair Share is influencing toward learning result on IPS in 4th grade student at SDN Sungguminasa II Somba Opu District Gowa Regency.

Understanding Innovative Potential (IP) in an ICT Context

DEFF Research Database (Denmark)

Rai, Sudhanshu

a dynamic perspective in its conception, operation and instantiation. I conclude this paper with insights on what I call the dynamic IP threshold arguing that being dynamic cannot be seen as a point in time but a threshold existing over time. I then discuss some implications. I suggest that firms need...... to consider IP as a long term investment not only in human capital but in the way the human capital is allowed to engage with new ideas. I suggest IP can be build using institutional logics that enable openness and collegiality....

Managing R&D and New Product Development

NARCIS (Netherlands)

von Zedtwitz, Maximilian; Friesike, Sascha; Gassmann, Oliver; Dodgson, Mark; Gann, David M.; Phillips, Nelson

2014-01-01

This article examines the importance of R&D and new product development and explores their management. It describes three central aspects of managing R&D and new product development in firms: the product development funnel, R&D portfolio management, and R&D organization. Concepts such as the ‘fuzzy

Voice over IP in the Local Exchange: A Case Study

OpenAIRE

Weiss, Martin B. H.; Kim, Hak-Ju

2001-01-01

There have been a small number of cost studies of Voice over IP (VoIP) in the academic literature. Generally, they have been for abstract networks, have not been focused on the public switched telephone network, or they have not included the operating costs. This paper presents the operating cost portion of our ongoing research project comparing circuit-switched and IP network costs for an existing local exchange carrier. We have found that (1) The operating cost differential between IP and c...

PENGEMBANGAN MODEL KOLABORASI JIGSAW ROLE PLAYING SEBAGAI UPAYA PENINGKATAN KEMAMPUAN BEKERJASAMA SISWA KELAS V SD PADA PELAJARAN IPS

Directory of Open Access Journals (Sweden)

Ika Ari Pratiwi

2015-11-01

Full Text Available Penelitian bertujuan untuk mengembangkan model kolaborasi jigsaw, role playing untuk meningkatkan kemampuan bekerjasama siswa yang valid, efektif dan praktis. Metode penelitian adalah penelitian dan pengembangan (R&D. Tahap uji coba pengembangan terdiri atas uji coba ahli, uji coba skala terbatas dan uji coba skala luas. Keefektifan model kolaborasi jigsaw role playing  diperoleh rata-rata 51,83 dalam kategori baik diterapkan dalam pelajaran IPS, peningkatan kemampuan bekerjasama siswa hasil N-gain = 0,56 dengan kategori sedang, peningkatan hasil belajar IPS N-gain = 0,50 dengan kategori sedang dan hasil ketuntasan klasikal pembelajaran IPS 97,14%.  Hasil respon guru dan siswa terhadap model yang digunakan adalah berkriteria baik. Model final penelitian ini menghasilkan model kolaborasi jigsaw role playing yang dikemas dalam suatu buku pedoman.

Security Risks in IP Telephony

Directory of Open Access Journals (Sweden)

Filip Rezac

2010-01-01

Full Text Available This paper deals with VoIP communication security and various techniques of VoIP attacks. We divided these threats in several categories according to their specific behaviour and their impact on the affected system. We also tried to find effective methods to prevent or mitigate these attacks. We focused our work on Spam over Internet Telephony (SPIT as a real threat for the future. We have developed both a tool generating SPIT attacks and AntiSPIT tool defending communication systems against SPIT attacks. AntiSPIT represents an effective protection based on statistical blacklist and works without participation of the called party which is a significant advantage.

TNP [N2-(m-Trifluorobenzyl, N6-(p-nitrobenzylpurine] ameliorates diet induced obesity and insulin resistance via inhibition of the IP6K1 pathway

Directory of Open Access Journals (Sweden)

Sarbani Ghoshal

2016-10-01

Full Text Available Objective: Obesity and type 2 diabetes (T2D lead to various life-threatening diseases such as coronary heart disease, stroke, osteoarthritis, asthma, and neurodegeneration. Therefore, extensive research is ongoing to identify novel pathways that can be targeted in obesity/T2D. Deletion of the inositol pyrophosphate (5-IP7 biosynthetic enzyme, inositol hexakisphosphate kinase-1 (IP6K1, protects mice from high fat diet (HFD induced obesity (DIO and insulin resistance. Yet, whether this pathway is a valid pharmacologic target in obesity/T2D is not known. Here, we demonstrate that TNP [N2-(m-Trifluorobenzyl, N6-(p-nitrobenzylpurine], a pan-IP6K inhibitor, has strong anti-obesity and anti-diabetic effects in DIO mice. Methods: Q-NMR, GTT, ITT, food intake, energy expenditure, QRT-PCR, ELISA, histology, and immunoblot studies were conducted in short (2.5-week- and long (10-week-term TNP treated DIO C57/BL6 WT and IP6K1-KO mice, under various diet and temperature conditions. Results: TNP, when injected at the onset of HFD-feeding, decelerates initiation of DIO and insulin resistance. Moreover, TNP facilitates weight loss and restores metabolic parameters, when given to DIO mice. However, TNP does not reduce weight gain in HFD-fed IP6K1-KO mice. TNP specifically enhances insulin sensitivity in DIO mice via Akt activation. TNP decelerates weight gain primarily by enhancing thermogenic energy expenditure in the adipose tissue. Accordingly, TNP's effect on body weight is partly abolished whereas its impact on glucose homeostasis is preserved at thermoneutral temperature. Conclusion: Pharmacologic inhibition of the inositol pyrophosphate pathway has strong therapeutic potential in obesity, T2D, and other metabolic diseases. Author Video: Author Video Watch what authors say about their articles Keywords: IP6K, Inositol pyrophosphate, Obesity, Energy expenditure, Diabetes, Akt

Satellite communication on pipeline supervision using TCP-IP Protocol; Comunicacao via satelite na supervisao de dutos usando o protocolo TCP-IP

Energy Technology Data Exchange (ETDEWEB)

Silva, Agliberto Pessoa da [PETROBRAS S.A., Rio de Janeiro, RJ (Brazil); Brunette, Sergio Henrique de Moraes

2003-07-01

Bit transparent type or X-25 protocols have been used in VSAT satellite communication by PETROBRAS pipeline Supervisory Control and Data Acquisition System (SCADA) as access protocol. Both solutions have inconveniences. By the first one, difficulties exist for analysis and diagnosis of connection flaws, and therefore, for a ready identification by the system management stations of abnormality location. On the other hand, the usage of the X-25 brings an additional over-head in the communication since this is not an available option in most of the equipment that compose the SCADA. The access to VSAT through Ethernet, in the opposite, makes available all networks management tools of the TCP/IP platform and it allows a direct connection to the field devices, since the main models of the several makers of Programmable Controllers and Remote Terminal Units have Ethernet port. An additional earnings is the possibility of standardization that this solution allows. This paper describes a series of communication tests between two Programmable Controllers communicating through the satellite, using a protocol over Ethernet/TCP/IP. (author)

Porovnání přesnosti metod pasivní IP geolokace

OpenAIRE

Mrázová, Andrea

2014-01-01

Táto práca je zameraná na vyhodnocovanie fyzickej polohy staníc v sieti Internet použitím pasívnych geolokačných metód, konkrétne za použitia geolokačných databáz. V prvej časti práce je všeobecne popísané, čo to IP geolokácia je, v druhej časti sú popísané aktívne a pasívne metódy IP geolokácie a tretia časť obsahuje popis praktickej časti bakalárskej práce a výsledky, ku ktorým sme dospeli. This thesis aims to evaluate the physical location of the stations connected to the Internet, focu...

BinQuasi: a peak detection method for ChIP-sequencing data with biological replicates.

Science.gov (United States)

Goren, Emily; Liu, Peng; Wang, Chao; Wang, Chong

2018-04-19

ChIP-seq experiments that are aimed at detecting DNA-protein interactions require biological replication to draw inferential conclusions, however there is no current consensus on how to analyze ChIP-seq data with biological replicates. Very few methodologies exist for the joint analysis of replicated ChIP-seq data, with approaches ranging from combining the results of analyzing replicates individually to joint modeling of all replicates. Combining the results of individual replicates analyzed separately can lead to reduced peak classification performance compared to joint modeling. Currently available methods for joint analysis may fail to control the false discovery rate at the nominal level. We propose BinQuasi, a peak caller for replicated ChIP-seq data, that jointly models biological replicates using a generalized linear model framework and employs a one-sided quasi-likelihood ratio test to detect peaks. When applied to simulated data and real datasets, BinQuasi performs favorably compared to existing methods, including better control of false discovery rate than existing joint modeling approaches. BinQuasi offers a flexible approach to joint modeling of replicated ChIP-seq data which is preferable to combining the results of replicates analyzed individually. Source code is freely available for download at https://cran.r-project.org/package=BinQuasi, implemented in R. pliu@iastate.edu or egoren@iastate.edu. Supplementary material is available at Bioinformatics online.

The effect of zirconia on flexural strength of IPS Empress 2 ceramic

Directory of Open Access Journals (Sweden)

Kermanshah H

2007-06-01

Full Text Available Background and Aim: All ceramic, inlay-retained resin bonded fixed partial denture is a conservative method for replacement of missing teeth, because of minimal tooth reduction. The connector between the retainer and the pontic is the weak point of these bridges. Reinforcement of ceramic core will increase the clinical longevity. The aim of this study was to determine the effect of zirconia on flexural strength of IPS Empress 2 core ceramic.Materials and Methods: In this experimental in vitro study, twenty eight bar shape specimens (17´3.1´3.1 mm were made of four different materials: (1 Slip casting in-ceram alumina core (control group (2 Hot-pressed lithium disilicate core ceramic (IPS Empress 2 (3 IPS Empress 2 with cosmopost (zirconia post inserted longitudinally in the center of the bar (4 IPS Empress 2 with cosmopost (zirconia post inserted longitudinally in bottom of the bar. Specimens were subjected to three-point flexure loading with the span of 15mm, at a cross-head speed of 0.5 mm/min. Failure loads were recorded and analyzed using one-way ANOVA and Tomhane Post-hoc tests and p<0.05 was set as the level of significance. Fractured surfaces were then observed by scanning electron microscope (SEM. Four additional samples were made as the third group, and zirconia-IPS interface was observed by SEM before fracture.Results: Mean values and standard deviations of three point flexural strengths of groups 1 to 4, were: 378.4±44.6, 258.6±27.5, 144.3±51.7, 230±22.3 MPa respectively. All the groups were statistically different from each other (P<0.05, except groups 2 and 4. The flexural strengths of groups 2, 3, 4 were significantly lower than group 1. Group 3 had the lowest flexural strength. SEM analysis showed that the initiated cracks propagated in the interface of zirconia post and IPS Empress 2 ceramic.Conclusion: Based on the results of this study, inserting zirconia post (cosmopost in IPS Empress 2 ceramic does not reinforce all

Ade-Ojo, IP

African Journals Online (AJOL)

Ade-Ojo, IP. Vol 40, No 2 (2013) - Articles Myasthenia gravis following chicken pox infection in a Nigerian primary school girl. Abstract PDF. ISSN: 0302-4660. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions ...

Mobile location services over the next generation IP core network

DEFF Research Database (Denmark)

Thongthammachart, Saowanee; Olesen, Henning

2003-01-01

network is changing from circuit-switched to packet-switched technology and evolving to an IP core network based on IPv6. The IP core network will allow all IP devices to be connected seamlessly. Due to the movement detection mechanism of Mobile IPv6, mobile terminals will periodically update....... The concept of mobile location services over the next generation IP networks is described. We also discuss the effectiveness of the short-range wireless network regarding a mobile user's position inside buildings and hotspot areas....

A comparison of the fabrication times of all-ceramic partial crowns: Cerec 3D vs IPS Empress.

Science.gov (United States)

Gozdowski, S; Reich, S

2009-01-01

Apart from precision, the time factor plays a decisive role in the fabrication of all-ceramic dental restorations. Therefore, the aim of this study was to compare two all-ceramic systems with regard to the time required for the fabrication of partial crowns [MODB]. The null hypothesis tested was that the fabrication times of CAD/CAM generated partial crowns are shorter than the fabrication times of partial crowns manufactured in the laboratory. In sixteen model pairs mounted in the articulator, which corresponded to different clinical situations, tooth 36 was prepared for an all-ceramic partial crown [MODB]. With the Cerec3D method [CHAIR], the fabrication of the restoration was simulated directly on the "phantom patient". The IPS Empress system [LAB] was used forthe indirectfabrication method via an impression of the phantom patient. Both methods were used for each preparation. The adhesive luting procedure was not simulated and, therefore, not measured. The mean processing times [hh:mm:ss] were 00:35:05 (SD +/- 03:27 min) for the Cerec method and 04:17:54 (SD +/- 26:01 min) for the Empress method. The mean time on the phantom patient for process-induced activities was 11:47 minutes (SD +/- 02:08 min) for the Cerec method and 03:58 minutes (SD +/- 02:50 min) for the Empress method. Time expenditure for fabrication is only one aspect in order to assess the suitability of a restoration system. Both methods enable the dentist to provide high quality all ceramic restorations. Although the Empress method showed a time advantage of 65% during the fitting phase and occlusal grinding-in on the phantom patient in comparison to the Cerec method, the time spent during the laboratory phase has to be considered as well.

Contextualização e práticas criativas na agricultura ecológica de Ipê e Antônio Prado/RS: o biofertilizante Super Magro como objeto epistêmico

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Daniela Oliveira

2017-08-01

Full Text Available This article analyzes the production process of knowledge and innovation in organic farming. It deals specifically with the biofertilizer Super Magro, an agricultural input developed by ecologist technicians and farmers from the municipalities of Ipê and Antônio Prado/RS. For this analysis, we present a theoretical framework that explores: a the role of the agricultural practice as locus and object (epistemic in the production of new knowledge and innovations and b the learning model and accumulation of contextual knowledge. The information analyzed was collected through semi-structured interviews and participant observation of ecologist technicians and farmers during the year of 2012. It can be stated that the development process of Super Magro was based on daily practice and creative reflection of technicians and farmers involved in the development of an organic farming. The process begins with the internalization of theoretical knowledge, especially the Trophobiosis Theory, and some practices already tested in other experiments related to organic production. This is followed by their contextualization or reconfiguration to better suit the knowledge and practices of farmers and the needs of existing crops, especially regarding the apple cultivation. The fact that the ecological farmers of Ipê and Antonio Prado are part of associations and of a nucleus of the Ecovida Network of Agroecology was fundamental to the activation of an intense process of socialization of the biofertilizer Super Magro among the families of ecological farmers that live in the region. Breaking with local boundaries and new environmental and social specificities, new reconfigurations occurred and new formulations of biofertilizers were, and still are, being proposed in several locations in Brazil. It can be concluded that, despite its importance in the agroecological and organic production in Brazil, this input was exclusively developed through informal processes of

Biobjective VoIP Service Management in Cloud Infrastructure

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Jorge M. Cortés-Mendoza

2016-01-01

Full Text Available Voice over Internet Protocol (VoIP allows communication of voice and/or data over the internet in less expensive and reliable manner than traditional ISDN systems. This solution typically allows flexible interconnection between organization and companies on any domains. Cloud VoIP solutions can offer even cheaper and scalable service when virtualized telephone infrastructure is used in the most efficient way. Scheduling and load balancing algorithms are fundamental parts of this approach. Unfortunately, VoIP scheduling techniques do not take into account uncertainty in dynamic and unpredictable cloud environments. In this paper, we formulate the problem of scheduling of VoIP services in distributed cloud environments and propose a new model for biobjective optimization. We consider the special case of the on-line nonclairvoyant dynamic bin-packing problem and discuss solutions for provider cost and quality of service optimization. We propose twenty call allocation strategies and evaluate their performance by comprehensive simulation analysis on real workload considering six months of the MIXvoip company service.

Galvannealing of (high-)manganese-alloyed TRIP- and X-IP registered -steel

Energy Technology Data Exchange (ETDEWEB)

Blumenau, M. [ThyssenKrupp Steel Europe AG, Bamenohler Strasse 211, D-57402 Finnentrop (Germany); Norden, M. [DOC Dortmunder Oberflaechencentrum GmbH, Eberhardstrasse 12, D-44145 Dortmund (Germany); Friedel, F.; Peters, K. [ThyssenKrupp Steel Europe AG, Kaiser-Wilhelm-Strasse 100, D-47166 Duisburg (Germany)

2010-12-15

In this study the influence of Mn on galvannealed coatings of 1.7% Mn-1.5% Al TRIP- and 23% Mn X-IP registered -steels was investigated. It is shown that the external selective oxides like Mn, Al and Si of the TRIP steel which occur after annealing at 800 C for 60 s at a dew point (DP) of -25 C (5% H{sub 2}) hamper the Fe/Zn-reaction during subsequent galvannealing. Preoxidation was beneficially utilized to increase the surface-reactivity of the TRIP steel under the same dew point conditions. The influence of Mn on the steel alloy was investigated by using a 23% Mn containing X-IP registered -steel which was bright annealed at 1100 C for 60 s at DP -50 C (5% H{sub 2}) to obtain a mainly oxide free surface prior to hot dip galvanizing (hdg) and subsequent galvannealing. As well known from the literature Mn alloyed to the liquid zinc melt stabilizes {delta}-phase at lower temperatures by participating in the Fe-Zn-phase reactions, it was expected that the metallic Mn of the X-IP registered -steel increases the Fe/Zn-reactivity in the same manner. The approximation of the effective diffusion coefficient (D{sub eff}(Fe)) during galvannealing was found to be higher than compared to a low alloyed steel reference. Contrary to the expectation no increased Fe/Zn-reaction was found by microscopic investigations. Residual {eta}- and {zeta}-phase fractions prove a hampered Fe/Zn-reaction. As explanation for the observed hampered Fe/Zn-reaction the lower Fe-content of the high-Mn-alloyed X-IP registered -steel was suggested as the dominating factor for galvannealing. (Copyright copyright 2010 Wiley-VCH Verlag GmbH and Co. KGaA, Weinheim)

Landscape-scale Ips typographus attack dynamics: from monitoring plots to GIS-based disturbance models

Czech Academy of Sciences Publication Activity Database

Jakuš, R.; Zajíčková, L.; Cudlín, Pavel; Blaženec, M.; Turčani, M.; Ježík, M.; Střelcová, K.; Lieutier, F.; Schlyter, F.

2011-01-01

Roč. 4, - (2011), s. 256-261 ISSN 1971-7458 R&D Projects: GA MŠk OC10022 Institutional research plan: CEZ:AV0Z60870520 Keywords : Spruce * Ips typographus * Attack * Drought * Host Subject RIV: GK - Forestry Impact factor: 0.507, year: 2011 http://www.sisef.it/iforest/pdf/?id=ifor0589-004

A survey of IP over ATM architectures

Energy Technology Data Exchange (ETDEWEB)

Chen, H.; Tsang, R.; Brandt, J.; Hutchins, J.

1997-07-01

Over the past decade, the Internet has burgeoned into a worldwide information highway consisting of approximately 5 million hosts on over 45,000 interconnected networks. This unprecedented growth, together with the introduction of multimedia workstations, has spurred the development of innovative applications that require high speed, low latency, and real-time transport. Today`s Internet can neither scale in its bandwidth nor guarantee the Quality of Services (QoS) necessary to meet these performance requirements. Many network researchers propose to use the Asynchronous Transfer Mode (ATM) technology as the underlying infrastructure for the next generation of workgroup, campus, and enterprise IP networks. Since ATM is significantly different from today`s legacy network technologies, efficient implementation of IP over ATM is especially challenging. This tutorial paper covers several existing proposals that integrate IP over ATM.

Secure IP mobility management for VANET

CERN Document Server

Taha, Sanaa

2013-01-01

This brief presents the challenges and solutions for VANETs' security and privacy problems occurring in mobility management protocols including Mobile IPv6 (MIPv6), Proxy MIPv6 (PMIPv6), and Network Mobility (NEMO). The authors give an overview of the concept of the vehicular IP-address configurations as the prerequisite step to achieve mobility management for VANETs, and review the current security and privacy schemes applied in the three mobility management protocols. Throughout the brief, the authors propose new schemes and protocols to increase the security of IP addresses within VANETs in

Secure Protocol and IP Core for Configuration of Networking Hardware IPs in the Smart Grid

Directory of Open Access Journals (Sweden)

Marcelo Urbina

2018-02-01

Full Text Available Nowadays, the incorporation and constant evolution of communication networks in the electricity sector have given rise to the so-called Smart Grid, which is why it is necessary to have devices that are capable of managing new communication protocols, guaranteeing the strict requirements of processing required by the electricity sector. In this context, intelligent electronic devices (IEDs with network architectures are currently available to meet the communication, real-time processing and interoperability requirements of the Smart Grid. The new generation IEDs include an Field Programmable Gate Array (FPGA, to support specialized networking switching architectures for the electric sector, as the IEEE 1588-aware High-availability Seamless Redundancy/Parallel Redundancy Protocol (HSR/PRP. Another advantage to using an FPGA is the ability to update or reconfigure the design to support new requirements that are being raised to the standards (IEC 61850. The update of the architecture implemented in the FPGA can be done remotely, but it is necessary to establish a cyber security mechanism since the communication link generates vulnerability in the case the attacker gains physical access to the network. The research presented in this paper proposes a secure protocol and Intellectual Property (IP core for configuring and monitoring the networking IPs implemented in a Field Programmable Gate Array (FPGA. The FPGA based implementation proposed overcomes this issue using a light Layer-2 protocol fully implemented on hardware and protected by strong cryptographic algorithms (AES-GCM, defined in the IEC 61850-90-5 standard. The proposed secure protocol and IP core are applicable in any field where remote configuration over Ethernet is required for IP cores in FPGAs. In this paper, the proposal is validated in communications hardware for Smart Grids.

Growth and symptomatological aspects in the acclimatization of ipê roxo

Directory of Open Access Journals (Sweden)

João Paulo Rodrigues Martins

2011-12-01

Full Text Available This work evaluated the influence of seal type and substrate type on pre-acclimatization, and symptomatological aspects relating to acclimatization of ipê-roxo. For the pre-acclimatization, ipê-roxo plants obtained through an in vitro zygotic embryo culture were aseptically inoculated in test tubes with different types of seal (cotton plug, plastic cap + parafilm and plastic lid and different substrates (agar, vermiculite and Plantmax® supplemented with a WPM culture medium with 1 gL-1 of activated charcoal, 10 mgL-1 of citric acid and 30 gL-1 of sucrose added. For the acclimatization, in vitro ipê-roxo plants were transplanted into 56-cm3 plastic tubes containing vermiculite and Plantmax® at a 2:1 ratio which had been previously autoclaved at 121oC and 1 atm for 20 minutes. Once transplanted, the plants were irrigated with different concentrations of the MS medium (25%, 50%, 75%, 100% and 150%, using distilled water as control. After 30 days, the effects of seal type and substrate type on pre-acclimatization were examined. Cotton can be recommended where Plantmax® or vermiculite is used as substrate. In the acclimatization it was noted that where plants were irrigated with distilled water and concentrations < 50% they showed symptoms of nutritional deficiency. Similar symptoms were observed when using MS medium at a concentration equal to or greater than 100%. The 75% MS concentration was found to be the most effective at maintaining the nutritional vigor of ipê-roxo seedlings in the process of acclimatization.

Intellectual Property and Strategic Agreements (IP/SA) | FNLCR Staging

Science.gov (United States)

IP/SA handles all invention issues including patents and copyrights. All employee inventionreports are filed through the IP/SA office for all activities under the OTS contract.Additionally,request for assignment ofcopyri

EPOS-IP WP10: services and data provision for the GNSS community

Science.gov (United States)

Fernandes, Rui

2016-04-01

The EPOS-IP WP10 - "GNSS Data & Products" is the Working Package of the EPOS-IP project in charge of implementing the necessary services in order that the geo-sciences community can access the existing Pan-European Geodetic Infrastructures. The WP10 is formed by representatives of the participating institutions (10) but it is also open to the entire geodetic community. In fact, WP10 also includes members from other institutions/countries that formally are not participating in the EPOS-IP. During the EPOS-IP project, the geodetic component of EPOS (WP10) is dealing essentially with Research Infrastructures focused on continuous operating GNSS (cGNSS). The option of concentrating the efforts on the presently most generalized geodetic tool supporting research on Solid Earth was decided in order to optimize the existing resources. Furthermore, although the focus is on Solid Earth applications, other research and technical applications (e.g., reference frames, meteorology, space weather) can also benefit from the efforts of WP10 towards the optimization of the geodetic resources in Europe. We will present and discuss the plans for the implementation of the thematic and core services (TCS) for GNSS data within EPOS and the related business plan. We will focus on strategies towards the implementation of the best solutions that will permit to the end-users, and in particular geo-scientists, to access the geodetic data, derived solutions, and associated metadata using transparent and uniform processes. The collaboration with EUREF is also an essential component of the implementation plan.

Prognostic value of CtIP/RBBP8 expression in breast cancer

International Nuclear Information System (INIS)

Soria-Bretones, Isabel; Sáez, Carmen; Ruíz-Borrego, Manuel; Japón, Miguel A; Huertas, Pablo

2013-01-01

CtIP/RBBP8 is a multifunctional protein involved in transcription, DNA replication, DNA repair by homologous recombination and the G1 and G2 checkpoints. Its multiple roles are controlled by its interaction with several specific factors, including the tumor suppressor proteins BRCA1 and retinoblastoma. Both its functions and interactors point to a putative oncogenic potential of CtIP/RBBP8 loss. However, CtIP/RBBP8 relevance in breast tumor appearance, development, and prognosis has yet to be established. We performed a retrospective analysis of CtIP/RBBP8 and RB1 levels by immunohistochemistry using 384 paraffin-embedded breast cancer biopsies obtained during tumor removal surgery. We have observed that low or no expression of CtIP/RBBP8 correlates with high-grade breast cancer and with nodal metastasis. Reduction on CtIP/RBBP8 is most common in hormone receptor (HR)-negative, HER2-positive, and basal-like tumors. We observed lower levels of RB1 on those tumors with reduced CtIP/RBBP8 levels. On luminal tumors, decreased but not absence of CtIP/RBBP8 levels correlate with increased disease-free survival when treated with a combination of hormone, radio, and chemo therapies

Integrating QoS and security functions in an IP-VPN gateway

Science.gov (United States)

Fan, Kuo-Pao; Chang, Shu-Hsin; Lin, Kuan-Ming; Pen, Mau-Jy

2001-10-01

IP-based Virtual Private Network becomes more and more popular. It can not only reduce the enterprise communication cost but also increase the revenue of the service provider. The common IP-VPN application types include Intranet VPN, Extranet VPN, and remote access VPN. For the large IP-VPN market, some vendors develop dedicated IP-VPN devices; while some vendors add the VPN functions into their existing network equipment such as router, access gateway, etc. The functions in the IP-VPN device include security, QoS, and management. The common security functions supported are IPSec (IP Security), IKE (Internet Key Exchange), and Firewall. The QoS functions include bandwidth control and packet scheduling. In the management component, policy-based network management is under standardization in IETF. In this paper, we discuss issues on how to integrate the QoS and security functions in an IP-VPN Gateway. We propose three approaches to do this. They are (1) perform Qos first (2) perform IPSec first and (3) reserve fixed bandwidth for IPSec. We also compare the advantages and disadvantages of the three proposed approaches.

China's Indigenous IP Policies -- Here to Stay?

OpenAIRE

Prud'homme, Dan

2013-01-01

In 2010 and 2011, foreign businesses and governments welcomed measures believed to dramatically reform a highly controversial branch of China’s indigenous innovation policy which provided government procurement preferences to applicants who can meet restrictive indigenous intellectual property (IP) rights requirements. However, this article describes specific examples of (what can be labeled) China’s “indigenous IP policy” that are still very much in force, in particular several programs link...

Polifemo, Sileno e le Cariti (Eur. Cycl. 578-584

Directory of Open Access Journals (Sweden)

Lenoardo Paganelli

1981-06-01

Full Text Available At Cycl. 578-584, lines 581 οὐκ ἄν φιλήσαιμ’. αἱ Χάριτες πειρῶσί με, and 583 κάλλιστα, νὴ τὰς Χάριτες κτλ., give no satisfactory sense. We suggest to read οὐκ ἂν φιλήσαιμ’ αἳ Χάριτες πειρῶσί με («I wouldn’t kiss those Graces, who are tempting me», and κάλλιστον ἢ τὰς Χάριτας (this Ganymede... «prettier than Graces», interpreting the whole passage as follows: the drunken Cyclops refuses to kiss «the Graces that» seem so well-disposed towards him, and prefers to lie with old Silenus, whom he regards as «nicer than the Graces themselves», theorizing that a young male is always more desirable than a female to him.

Internetiside VoIP sobib ka ettevõtteile / Valdur Laid

Index Scriptorium Estoniae

Laid, Valdur, 1969-

2005-01-01

Ilmunud ka: Delovõje Vedomosti 8. juuni lk. 19. Kommunikatsiooni liikumisest internetti ehk IP-võrku ning selle võimalustest ettevõtjaile. Vt. samas: Väikefirmade IP-lahendus jõuab aasta lõpus massturule

Age-dependent changes in diastolic Ca{sup 2+} and Na{sup +} concentrations in dystrophic cardiomyopathy: Role of Ca{sup 2+} entry and IP{sub 3}

Energy Technology Data Exchange (ETDEWEB)

Mijares, Alfredo [Instituto Venezolano de Investigaciones Científicas, Centro de Biofísica y Bioquímica, Caracas (Venezuela, Bolivarian Republic of); Altamirano, Francisco [Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616 (United States); Kolster, Juan [Centro de Investigaciones Biomédicas, México D.F. (Mexico); Adams, José A. [Division of Neonatology, Mount Sinai Medical Center, Miami, FL 33140 (United States); López, José R., E-mail: jrlopez@ucdavis.edu [Instituto Venezolano de Investigaciones Científicas, Centro de Biofísica y Bioquímica, Caracas (Venezuela, Bolivarian Republic of); Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616 (United States)

2014-10-03

Highlights: • Age-dependent increase in [Ca{sup 2+}]{sub d} and [Na{sup +}]{sub d} in mdx cardiomyocytes. • Gadolinium significantly reduced both [Ca{sup 2+}]{sub d} and [Na{sup +}]{sub d} at all ages. • IP{sub 3}-pathway inhibition reduced cations concentrations in dystrophic cardiomyocytes. - Abstract: Duchenne muscular dystrophy (DMD) is a lethal X-inherited disease caused by dystrophin deficiency. Besides the relatively well characterized skeletal muscle degenerative processes, DMD is also associated with a dilated cardiomyopathy that leads to progressive heart failure at the end of the second decade. The aim of the present study was to characterize the diastolic Ca{sup 2+} concentration ([Ca{sup 2+}]{sub d}) and diastolic Na{sup +} concentration ([Na{sup +}]{sub d}) abnormalities in cardiomyocytes isolated from 3-, 6-, 9-, and 12-month old mdx mice using ion-selective microelectrodes. In addition, the contributions of gadolinium (Gd{sup 3+})-sensitive Ca{sup 2+} entry and inositol triphosphate (IP{sub 3}) signaling pathways in abnormal [Ca{sup 2+}]{sub d} and [Na{sup +}]{sub d} were investigated. Our results showed an age-dependent increase in both [Ca{sup 2+}]{sub d} and [Na{sup +}]{sub d} in dystrophic cardiomyocytes compared to those isolated from age-matched wt mice. Gd{sup 3+} treatment significantly reduced both [Ca{sup 2+}]{sub d} and [Na{sup +}]{sub d} at all ages. In addition, blockade of the IP{sub 3}-pathway with either U-73122 or xestospongin C significantly reduced ion concentrations in dystrophic cardiomyocytes. Co-treatment with U-73122 and Gd{sup 3+} normalized both [Ca{sup 2+}]{sub d} and [Na{sup +}]{sub d} at all ages in dystrophic cardiomyocytes. These data showed that loss of dystrophin in mdx cardiomyocytes produced an age-dependent intracellular Ca{sup 2+} and Na{sup +} overload mediated at least in part by enhanced Ca{sup 2+} entry through Gd{sup 3+} sensitive transient receptor potential channels (TRPC), and by IP{sub 3} receptors.

Disruption of dopamine D1/D2 receptor complex is involved in the function of haloperidol in cardiac H9c2 cells.

Science.gov (United States)

Lencesova, L; Szadvari, I; Babula, P; Kubickova, J; Chovancova, B; Lopusna, K; Rezuchova, I; Novakova, Z; Krizanova, O; Novakova, M

2017-12-15

Haloperidol is an antipsychotic agent and acts as dopamine D2 receptor (D2R) antagonist, as a prototypical ligand of sigma1 receptors (Sig1R) and it increases expression of type 1 IP 3 receptors (IP 3 R1). However, precise mechanism of haloperidol action on cardiomyocytes through dopaminergic signaling was not described yet. This study investigated a role of dopamine receptors in haloperidol-induced increase in IP 3 R1 and Sig1R, and compared physiological effect of melperone and haloperidol on basic heart parameters in rats. We used differentiated NG-108 cells and H9c2 cells. Gene expression, Western blot and immunofluorescence were used to evaluate haloperidol-induced differences; proximity ligation assay (PLA) and immunoprecipitation to determine interactions of D1/D2 receptors. To evaluate cardiac parameters, Wistar albino male rats were used. We have shown that antagonism of D2R with either haloperidol or melperone results in upregulation of both, IP 3 R1 and Sig1R, which is associated with increased D2R, but reduced D1R expression. Immunofluorescence, immunoprecipitation and PLA support formation of heteromeric D1/D2 complexes in H9c2 cells. Treatment with haloperidol (but not melperone) caused decrease in systolic and diastolic blood pressure and significant increase in heart rate. Because D1R/D2R complexes can engage Gq-like signaling in other experimental systems, these results are consistent with the possibility that disruption of D1R/D2R complex in H9c2 cells might cause a decrease in IP 3 R1 activity, which in turn may account for the increase expression of IP 3 R and Sig1R. D2R is probably not responsible for changes in cardiac parameters, since melperone did not have any effect. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

All-IP-Ethernet architecture for real-time sensor-fusion processing

Science.gov (United States)

Hiraki, Kei; Inaba, Mary; Tezuka, Hiroshi; Tomari, Hisanobu; Koizumi, Kenichi; Kondo, Shuya

2016-03-01

Serendipter is a device that distinguishes and selects very rare particles and cells from huge amount of population. We are currently designing and constructing information processing system for a Serendipter. The information processing system for Serendipter is a kind of sensor-fusion system but with much more difficulties: To fulfill these requirements, we adopt All IP based architecture: All IP-Ethernet based data processing system consists of (1) sensor/detector directly output data as IP-Ethernet packet stream, (2) single Ethernet/TCP/IP streams by a L2 100Gbps Ethernet switch, (3) An FPGA board with 100Gbps Ethernet I/F connected to the switch and a Xeon based server. Circuits in the FPGA include 100Gbps Ethernet MAC, buffers and preprocessing, and real-time Deep learning circuits using multi-layer neural networks. Proposed All-IP architecture solves existing problem to construct large-scale sensor-fusion systems.

Quantitative evaluation of interstitial pneumonia using 3D-curved high-resolution CT imaging parallel to the chest wall: A pilot study.

Directory of Open Access Journals (Sweden)

Hiroyasu Umakoshi

Full Text Available To quantify the imaging findings of patients with interstitial pneumonia (IP and emphysema using three-dimensional curved high-resolution computed tomography (3D-cHRCT at a constant depth from the chest wall, and compare the results to visual assessment of IP and each patient's diffusing capacity of the lungs for carbon monoxide (DLco.We retrospectively reviewed the axial CT findings and pulmonary function test results of 95 patients with lung cancer (72 men and 23 women, aged 45-84 years with or without IP, as follows: non-IP (n = 47, mild IP (n = 31, and moderate IP (n = 17. The 3D-cHRCT images of the lung at a 1-cm depth from the chest wall were reconstructed automatically using original software; total area (TA, high-attenuation area (HAA >-500 HU, and low-attenuation area (LAA <-950 HU were calculated on a workstation. The %HAA and %LAA were calculated as follows: [Formula: see text], and [Formula: see text].The %HAA and %LAA respective values were 3.2±0.9 and 27.7±8.2, 3.9±1.2 and 27.6±5.9, and 6.9±2.2 and 25.4±8.7 in non-IP, mild IP, and moderate IP patients, respectively. There were significant differences in %HAA between the 3 groups of patients (P<0.001, but no differences in %LAA (P = 0.558. Multiple linear regression analysis revealed that %HAA and %LAA were negatively correlated with predicted DLco (standard partial regression coefficient [b*] = -0.453, P<0.001; b* = -0.447, P<0.001, respectively.The %HAA and %LAA values computed using 3D-cHRCT were significantly correlated with DLco and may be important quantitative parameters for both IP and emphysema.

Unjuk Kerja IP PBX Asterisk dan FreeSWITCH pada Topologi Bertingkat di Jaringan Kampus

Directory of Open Access Journals (Sweden)

Iwan Setiawan

2017-08-01

Full Text Available Internet Protocol-based Private Branch Exchange (IP PBX diperlukan untuk menghubungkan panggilan antar perangkat komunikasi Voice over Internet Protocol (VoIP di sebuah jaringan lokal (LAN. Dengan adanya IP PBX, layanan VoIP dapat disediakan di atas jaringan data/IP yang sudah tergelar. Penelitian ini kami lakukan untuk mengetahui unjuk kerja VoIP pada dua IP PBX yang menggunakan perangkat lunak server Asterisk dan FreeSWITCH. Kami merancang sebuah arsitektur jaringan eksperimen yang diadaptasi dari topologi bertingkat pada jaringan kampus (CAN di lokasi penelitian dengan hierarki perangkat yang terdiri dari core switch, distribution switch, dan access switch. Kedua IP PBX ditempatkan pada hierarki yang berbeda pada topologi jaringan tersebut agar dapat diketahui pengaruhnya terhadap unjuk kerja VoIP. Konsep eksperimen ini diharapkan dapat menjadi salah satu dasar untuk mendesain arsitektur IP PBX secara terpusat dan tersebar pada jaringan kampus. Unjuk kerja VoIP kami ukur dengan parameter-parameter Quality of Service (QoS dan Quality of Experience (QoE. Selain itu, kami juga mengukur konsumsi prosesor dan memori yang dipakai oleh perangkat lunak server VoIP pada saat komunikasi terjadi. Pengukuran dilakukan dengan skenario phone-to-phone pada jaringan eksperimen yang terhubung ke jaringan kampus aktif. Hasil penelitian menunjukkan bahwa penempatan IP PBX di hierarki yang berbeda pada topologi jaringan berpengaruh terhadap unjuk kerja VoIP khususnya pada IP PBX Asterisk. Ketika dibandingkan, unjuk kerja IP PBX FreeSWITCH dalam hal QoS dan QoE sedikit lebih baik daripada Asterisk pada rerata latensi/delay, jitter, Mean Opinion Score (MOS, dan konsumsi memori yaitu 41,012 ms, 0,060 ms, 5, dan 1 % untuk IP PBX 1 serta 41,016 ms, 0,066 ms, 5, dan 0,5 % untuk IP PBX 2

Voice over IP phone calls from your smartphone

CERN Multimedia

2014-01-01

All CERN users do have a Lync account (see here) and can use Instant Messaging, presence and other features. In addition, if your number is activated on Lync IP Phone(1) system then you can make standard phone calls from your computer (Windows/Mac).   Recently, we upgraded the infrastructure to Lync 2013. One of the major features is the possibility to make Voice over IP phone calls from a smartphone using your CERN standard phone number (not mobile!). Install Lync 2013 on iPhone/iPad, Android or Windows Phone, connect to WiFi network and make phone calls as if you were in your office. There will be no roaming charges because you will be using WiFi to connect to CERN phone system(2). Register here to the presentation on Tuesday 29 April at 11 a.m. in the Technical Training Center and see the most exciting features of Lync 2013.   Looking forward to seeing you! The Lync team (1) How to register on Lync IP Phone system: http://information-technology.web.cern.ch/book/lync-ip-phone-serv...

Validation of the Spanish version of the Irrational Procrastination Scale (IPS.

Directory of Open Access Journals (Sweden)

Georgina Guilera

Full Text Available The present study is centered in adapting and validating a Spanish version of the Irrational Procrastination Scale (IPS. The sample consists of 365 adults aged 18-77 years (M = 37.70, SD = 12.64. Participants were administered two measures of procrastination, the IPS and the Decisional Procrastination Questionnaire, as well as the Big Five Inventory, and the Satisfaction With Life Scale. First, the factor and replication analysis revealed that the internal structure of the scale is clearly one-dimensional, supporting the idea that IPS seems to measure general procrastination as a single trait. Second, the internal consistency is satisfactory as is the temporal stability of the IPS scores. Third, the correlations encountered between the IPS scores and other measures of procrastination, personality traits and satisfaction with life are all in the expected direction and magnitude. Finally, consistent with previous research, procrastination is related to age, with the youngest being the most procrastinating group. This study represents the first attempt in adapting and validating the IPS measure of procrastination into Spanish. Results suggest that the Spanish version of the IPS offers valid and reliable scores when applied to adult population.

RIDES: Robust Intrusion Detection System for IP-Based Ubiquitous Sensor Networks.

Science.gov (United States)

Amin, Syed Obaid; Siddiqui, Muhammad Shoaib; Hong, Choong Seon; Lee, Sungwon

2009-01-01

The IP-based Ubiquitous Sensor Network (IP-USN) is an effort to build the "Internet of things". By utilizing IP for low power networks, we can benefit from existing well established tools and technologies of IP networks. Along with many other unresolved issues, securing IP-USN is of great concern for researchers so that future market satisfaction and demands can be met. Without proper security measures, both reactive and proactive, it is hard to envisage an IP-USN realm. In this paper we present a design of an IDS (Intrusion Detection System) called RIDES (Robust Intrusion DEtection System) for IP-USN. RIDES is a hybrid intrusion detection system, which incorporates both Signature and Anomaly based intrusion detection components. For signature based intrusion detection this paper only discusses the implementation of distributed pattern matching algorithm with the help of signature-code, a dynamically created attack-signature identifier. Other aspects, such as creation of rules are not discussed. On the other hand, for anomaly based detection we propose a scoring classifier based on the SPC (Statistical Process Control) technique called CUSUM charts. We also investigate the settings and their effects on the performance of related parameters for both of the components.

Validation of the Spanish version of the Irrational Procrastination Scale (IPS)

Science.gov (United States)

Guilera, Georgina; Penelo, Eva; Morin, Christopher; Steel, Piers; Gómez-Benito, Juana

2018-01-01

The present study is centered in adapting and validating a Spanish version of the Irrational Procrastination Scale (IPS). The sample consists of 365 adults aged 18–77 years (M = 37.70, SD = 12.64). Participants were administered two measures of procrastination, the IPS and the Decisional Procrastination Questionnaire, as well as the Big Five Inventory, and the Satisfaction With Life Scale. First, the factor and replication analysis revealed that the internal structure of the scale is clearly one-dimensional, supporting the idea that IPS seems to measure general procrastination as a single trait. Second, the internal consistency is satisfactory as is the temporal stability of the IPS scores. Third, the correlations encountered between the IPS scores and other measures of procrastination, personality traits and satisfaction with life are all in the expected direction and magnitude. Finally, consistent with previous research, procrastination is related to age, with the youngest being the most procrastinating group. This study represents the first attempt in adapting and validating the IPS measure of procrastination into Spanish. Results suggest that the Spanish version of the IPS offers valid and reliable scores when applied to adult population. PMID:29304119

Validation of the Spanish version of the Irrational Procrastination Scale (IPS).

Science.gov (United States)

Guilera, Georgina; Barrios, Maite; Penelo, Eva; Morin, Christopher; Steel, Piers; Gómez-Benito, Juana

2018-01-01

The present study is centered in adapting and validating a Spanish version of the Irrational Procrastination Scale (IPS). The sample consists of 365 adults aged 18-77 years (M = 37.70, SD = 12.64). Participants were administered two measures of procrastination, the IPS and the Decisional Procrastination Questionnaire, as well as the Big Five Inventory, and the Satisfaction With Life Scale. First, the factor and replication analysis revealed that the internal structure of the scale is clearly one-dimensional, supporting the idea that IPS seems to measure general procrastination as a single trait. Second, the internal consistency is satisfactory as is the temporal stability of the IPS scores. Third, the correlations encountered between the IPS scores and other measures of procrastination, personality traits and satisfaction with life are all in the expected direction and magnitude. Finally, consistent with previous research, procrastination is related to age, with the youngest being the most procrastinating group. This study represents the first attempt in adapting and validating the IPS measure of procrastination into Spanish. Results suggest that the Spanish version of the IPS offers valid and reliable scores when applied to adult population.

Two-year clinical evaluation of IPS Empress II ceramic onlays/inlays.

Science.gov (United States)

Tagtekin, D A; Ozyöney, G; Yanikoglu, F

2009-01-01

The stronger the ceramic material, the longer the restoration stays in the mouth. The current study evaluated the two-year clinical performance of a strong ceramic system, IPS Empress II, with increased strength on onlay/inlay restorations of molars. Teeth from 35 patients, including three premolars and 32 molars, were prepared for 28 onlay and seven inlay restorations with IPS Empress II ceramics. The restorations were cemented with a highly viscous, dual-curing luting composite cement (Bifix) and evaluated by two examiners using USPHS criteria at baseline (one week following insertion), six months, one year and two years. The baseline scores and recalls were assessed by Wilcoxon signed rank test. Statistically significant marginal discoloration at the Bravo level was found at the 12- and 24-month recalls (p=0.046). One debonding was statistically insignificant. No changes were observed with respect to anamnesis, such as any symptom from the TMJ or masticatory muscles. No restorations were replaced due to hypersensitivity or were missing at the two-year evaluation. Any wear on the restoration, antagonist tooth or any changes of proximal contacts were not observed. IPS Empress II Ceramics were found to be appropriate as onlay/inlay restorations for clinical use under the conditions of the current study.

UPTF test 21D counterpart test in the MIDAS test facility

International Nuclear Information System (INIS)

Yoon, B. C.; Ah, D. J.; Joo, I. C.; Kwon, T. S.; Park, W. M.; Song, C. H.

2002-01-01

This paper describes the experimental results of UPTF Test 21D counterpart tests in the downcomer during the late reflood phase of LBLOCA. The experiments have been performed in the MIDAS test facility using superheated steam and water. The test condition was determined,based on the test results of UPTF Test 21D, by applying the 'modified linear scaling method of 1/4.077 length scale. The tests of ECC direct bypass and void height are performed separately to estimate each phenomena quantitatively. The tests were carried out by varying the injection steam flow rate of intact cold legs widely to investigate the effect of steam flow rate on the direct bypass fraction and void height. In the tests, separate effect tests have been performed in cases of DVI-1,DVI- 2 and DVI-1 and 2 injections to see the direct bypass fraction according to the DVI nozzle combination. From the tests, we found that the fraction of direct ECC bypass and the void height observed in the MIDAS test facility reasonably well agree with those of UPTF test 21- D. It confirms that the applied 'modified linear scaling law' reproduces major thermal hydraulics phenomena in the downcomer during the LBLOCA reflood phase

Long-term Cerec 3D chairside bridges milled from IPS e.max CAD LT blocks.

Science.gov (United States)

Schneider, Oliver

The experienced Cerec user can manufacture high-quality, esthetic anterior and posterior bridges from IPS e.max CAD in a manageable 3-hour chairside session. On the basis of over 8 years of experience, it can be said that these restorations are clinically very well proven, provided they are used within the range of recommended indications. Experimental retainer bridges with extensions can be seen as highly interesting alternatives, although more clinical data are required for further confirmation.

ELISA-based assay for IP-10 detection from filter paper samples

DEFF Research Database (Denmark)

Drabe, Camilla Heldbjerg; Blauenfeldt, Thomas; Ruhwald, Morten

2014-01-01

IP-10 is a small pro-inflammatory chemokine secreted primarily from monocytes and fibroblasts. Alterations in IP-10 levels have been associated with inflammatory conditions including viral and bacterial infections, immune dysfunction, and tumor development. IP-10 is increasingly recognized as a b...... as a biomarker that predicts severity of various diseases and can be used in the immunodiagnostics of Mycobacterium tuberculosis and cytomegalovirus infection. Here, we describe an ELISA-based method to detect IP-10 from dried blood and plasma spot samples....

Design of IP Camera Access Control Protocol by Utilizing Hierarchical Group Key

Directory of Open Access Journals (Sweden)

Jungho Kang

2015-08-01

Full Text Available Unlike CCTV, security video surveillance devices, which we have generally known about, IP cameras which are connected to a network either with or without wire, provide monitoring services through a built-in web-server. Due to the fact that IP cameras can use a network such as the Internet, multiple IP cameras can be installed at a long distance and each IP camera can utilize the function of a web server individually. Even though IP cameras have this kind of advantage, it has difficulties in access control management and weakness in user certification, too. Particularly, because the market of IP cameras did not begin to be realized a long while ago, systems which are systematized from the perspective of security have not been built up yet. Additionally, it contains severe weaknesses in terms of access authority to the IP camera web server, certification of users, and certification of IP cameras which are newly installed within a network, etc. This research grouped IP cameras hierarchically to manage them systematically, and provided access control and data confidentiality between groups by utilizing group keys. In addition, IP cameras and users are certified by using PKI-based certification, and weak points of security such as confidentiality and integrity, etc., are improved by encrypting passwords. Thus, this research presents specific protocols of the entire process and proved through experiments that this method can be actually applied.

An ethernet/IP security review with intrusion detection applications

International Nuclear Information System (INIS)

Laughter, S. A.; Williams, R. D.

2006-01-01

Supervisory Control and Data Acquisition (SCADA) and automation networks, used throughout utility and manufacturing applications, have their own specific set of operational and security requirements when compared to corporate networks. The modern climate of heightened national security and awareness of terrorist threats has made the security of these systems of prime concern. There is a need to understand the vulnerabilities of these systems and how to monitor and protect them. Ethernet/IP is a member of a family of protocols based on the Control and Information Protocol (CIP). Ethernet/IP allows automation systems to be utilized on and integrated with traditional TCP/IP networks, facilitating integration of these networks with corporate systems and even the Internet. A review of the CIP protocol and the additions Ethernet/IP makes to it has been done to reveal the kind of attacks made possible through the protocol. A set of rules for the SNORT Intrusion Detection software is developed based on the results of the security review. These can be used to monitor, and possibly actively protect, a SCADA or automation network that utilizes Ethernet/IP in its infrastructure. (authors)

CATCHprofiles: Clustering and Alignment Tool for ChIP Profiles

DEFF Research Database (Denmark)

G. G. Nielsen, Fiona; Galschiøt Markus, Kasper; Møllegaard Friborg, Rune

2012-01-01

IP-profiling data and detect potentially meaningful patterns, the areas of enrichment must be aligned and clustered, which is an algorithmically and computationally challenging task. We have developed CATCHprofiles, a novel tool for exhaustive pattern detection in ChIP profiling data. CATCHprofiles is built upon...... a computationally efficient implementation for the exhaustive alignment and hierarchical clustering of ChIP profiling data. The tool features a graphical interface for examination and browsing of the clustering results. CATCHprofiles requires no prior knowledge about functional sites, detects known binding patterns...... it an invaluable tool for explorative research based on ChIP profiling data. CATCHprofiles and the CATCH algorithm run on all platforms and is available for free through the CATCH website: http://catch.cmbi.ru.nl/. User support is available by subscribing to the mailing list catch-users@bioinformatics.org....

Numerical study of IP3-induced Ca2+ spiral pattern evolution

International Nuclear Information System (INIS)

Tang Jun; Ma Jun; Yi Ming; Jia Ya

2008-01-01

The effect of change in concentration of messenger molecule inositol 1,4,5-trisphosphate (IP 3 ) on intracellular Ca 2+ spiral pattern evolution is studied numerically. The results indicate that when the IP 3 concentration decreases from 0.27 μM, a physiologically reasonable value, to different values, the spiral centre drifts to the edge of the medium and disappears for a small enough IP 3 concentration. The instability of spiral pattern can be understood in terms of excitability-change controlled by the IP 3 concentration. On the other hand, when the IP 3 concentration increases from 0.27 μM, a homogeneous area with a high Ca 2+ concentration emerges and competes with the spiral pattern. A high enough IP 3 concentration can lead the homogeneous area to occupy the whole medium. The instability of spiral pattern is ascribed to the change in stability of a stationary state with a high Ca 2+ concentration. (general)

Application of Mobile-ip to Space and Aeronautical Networks

Science.gov (United States)

Leung, Kent; Shell, Dan; Ivancic, William D.; Stewart, David H.; Bell, Terry L.; Kachmar, Brian A.

2001-01-01

The National Aeronautics and Space Administration (NASA) is interested in applying mobile Internet protocol (mobile-ip) technologies to its space and aeronautics programs. In particular, mobile-ip will play a major role in the Advanced Aeronautic Transportation Technology (AAT-F), the Weather Information Communication (WINCOMM), and the Small Aircraft Transportation System (SATS) aeronautics programs. This paper describes mobile-ip and mobile routers--in particular, the features, capabilities, and initial performance of the mobile router are presented. The application of mobile-router technology to NASA's space and aeronautics programs is also discussed.

IP Controller Design for Uncertain Two-Mass Torsional System Using Time-Frequency Analysis

Directory of Open Access Journals (Sweden)

Jing Cui

2018-01-01

Full Text Available With the development of industrial production, drive systems are demanded for larger inertias of motors and load machines, whereas shafts should be lightweight. In this situation, it will excite mechanical vibrations in load side, which is harmful for industrial production when the motor works. Because of the complexity of the flexible shaft, it is often difficult to calculate stiffness coefficient of the flexible shaft. Furthermore, only the velocity of driving side could be measured, whereas the driving torque, the load torque, and the velocity of load side are immeasurable. Therefore, it is inconvenient to design the controller for the uncertain system. In this paper, a low-order IP controller is designed for an uncertain two-mass torsional system based on polynomial method and time-frequency analysis (TFA. IP controller parameters are calculated by inertias of driving side and load side as well as the resonant frequency based on polynomial method. Therein, the resonant frequency is identified using the time-frequency analysis (TFA of the velocity step response of the driving side under the open-loop system state, which can not only avoid harmful persistent start-stop excitation signal of the traditional method, but also obtain high recognition accuracy under the condition of weak vibration signal submerged in noise. The effectiveness of the designed IP controller is verified by groups of experiments. Experimental results show that good performance for vibration suppression is obtained for uncertain two-mass torsional system in a medium-low shaft stiffness condition.

Empirical methods for controlling false positives and estimating confidence in ChIP-Seq peaks

Directory of Open Access Journals (Sweden)

Courdy Samir J

2008-12-01

Full Text Available Abstract Background High throughput signature sequencing holds many promises, one of which is the ready identification of in vivo transcription factor binding sites, histone modifications, changes in chromatin structure and patterns of DNA methylation across entire genomes. In these experiments, chromatin immunoprecipitation is used to enrich for particular DNA sequences of interest and signature sequencing is used to map the regions to the genome (ChIP-Seq. Elucidation of these sites of DNA-protein binding/modification are proving instrumental in reconstructing networks of gene regulation and chromatin remodelling that direct development, response to cellular perturbation, and neoplastic transformation. Results Here we present a package of algorithms and software that makes use of control input data to reduce false positives and estimate confidence in ChIP-Seq peaks. Several different methods were compared using two simulated spike-in datasets. Use of control input data and a normalized difference score were found to more than double the recovery of ChIP-Seq peaks at a 5% false discovery rate (FDR. Moreover, both a binomial p-value/q-value and an empirical FDR were found to predict the true FDR within 2–3 fold and are more reliable estimators of confidence than a global Poisson p-value. These methods were then used to reanalyze Johnson et al.'s neuron-restrictive silencer factor (NRSF ChIP-Seq data without relying on extensive qPCR validated NRSF sites and the presence of NRSF binding motifs for setting thresholds. Conclusion The methods developed and tested here show considerable promise for reducing false positives and estimating confidence in ChIP-Seq data without any prior knowledge of the chIP target. They are part of a larger open source package freely available from http://useq.sourceforge.net/.

Determination of Disulfide Bond Connectivity of Cysteine-rich Peptide IpTx{sub a}

Energy Technology Data Exchange (ETDEWEB)

Lee, Chul Won; Kim, Jim Il [Chonnam National Univ., Gwangju (Korea, Republic of); Sato, Kazuki [Fukuoka Women' s Univ., Fukuoka (Japan)

2013-06-15

Cysteine-rich peptides stabilized by intramolecular disulfide bonds have often been isolated from venoms of microbes, animals and plants. These peptides typically have much higher stability and improved biopharmaceutical properties compared to their linear counterparts. Therefore the correct disulfide bond formation of small proteins and peptides has been extensively studied for a better understanding of their folding mechanism and achieving efficient generation of the naturally occurring biologically active product. Imperatoxin A (IpTx{sub a}), a peptide toxin containing 6 cysteine residues, was isolated from the venom of scorpion Pandinus imperator, selectively binds the ryanodine receptors and activates Ca{sup 2+} release from sarcoplasmic reticulum (SR). IpTx{sub a} increases the binding of ryanodine to ryanodine receptors (RyRs) and encourages reconstituted single channel to induce subconductance states.

Beyond iPS!

Directory of Open Access Journals (Sweden)

Editorial

2012-01-01

open acknowledgement that he chose a research career as he was not good in surgical procedures, is something that teaches us to keep going ahead even when we know our limitations. Another important quality we appreciate in him is his team-spirit and perseverance. Not only as a member of the university Judo team, but after starting the iPS research when sourcing research funds was difficult, he plunged into organizing a marathon run, which he completed till the finish line is a marvelous feat to showcase his perseverance. As this issue is published with articles on molecular profiling of human breast cancer initiating cells, allogeneic amniotic membrane-derived mesenchymal stromal cell (AMSC transplantation and mononuclear stem cell therapy, we look back, recognize and salute the genius of Alexander Maximov, who coined the term “Stem Cell” in 1908, Joseph Altman & Gopal D.Das who reported the post-natal neurogenesis in the 1960s and James E.Till & Ernest McCulloch, who discovered the presence of self-renewing cells in bone-marrow in 1963 that later led to the bone-marrow transplantation as a treatment. “…But they, while their companions slept, were toiling upward in the night.” - Henry Wadsworth Longfellow

ATM QoS Experiments Using TCP Applications: Performance of TCP/IP Over ATM in a Variety of Errored Links

Science.gov (United States)

Frantz, Brian D.; Ivancic, William D.

2001-01-01

Asynchronous Transfer Mode (ATM) Quality of Service (QoS) experiments using the Transmission Control Protocol/Internet Protocol (TCP/IP) were performed for various link delays. The link delay was set to emulate a Wide Area Network (WAN) and a Satellite Link. The purpose of these experiments was to evaluate the ATM QoS requirements for applications that utilize advance TCP/IP protocols implemented with large windows and Selective ACKnowledgements (SACK). The effects of cell error, cell loss, and random bit errors on throughput were reported. The detailed test plan and test results are presented herein.

Diagnostic potential of virtual bronchoscopy: advantages in comparison with axial CT slices, MPR and mIP?

International Nuclear Information System (INIS)

Rapp-Bernhardt, U.; Doehring, W.; Bernhardt, T.M.; Welte, T.; Kropf, S.

2000-01-01

The aim of this study was to evaluate the diagnostic potential of virtual endoscopy (VE) and to compare it with axial CT slices, multiplanar reconstructions (MPR), minimal intensity projections (mIP), and bronchoscopy in patients diagnosed with bronchogenic carcinoma. Thirty patients underwent a spiral CT. Axial CT images were transferred to an Onyx workstation (Silicon Graphics, Sun Microsystems, Mountain View, Calif.) for performing virtual endoscopy. Accuracy for this procedure was tested by three radiologists on a monitor in comparison with axial CT slices, MPR, mIP, and bronchoscopy concerning the localization and degree of stenoses. Endoluminal tumors were identified by virtual bronchoscopy with no statistically significant difference of localization or grading of stenosis in comparison with bronchoscopy, axial CT slices, MPR and mIP. Axial CT slices, MPR, and mIP showed poorer results with over- or underestimation of stenoses compared with VE and bronchoscopy. Passing of stenoses was only possible with VE in 5 patients. Virtual endoscopy is a non-invasive method for identification of endoluminal tumors and is comparable to real bronchoscopy. (orig.)

Diagnostic potential of virtual bronchoscopy: advantages in comparison with axial CT slices, MPR and mIP?

Energy Technology Data Exchange (ETDEWEB)

Rapp-Bernhardt, U.; Doehring, W.; Bernhardt, T.M. [Department of Diagnostic Radiology, Otto-von-Guericke University, Magdeburg (Germany); Welte, T. [Department of Cardiology, Angiology, and Pneumology, Otto-von-Guericke University, Magdeburg (Germany); Kropf, S. [Department of Biometrics and Medical Informatics, Otto-von-Guericke University, Magdeburg (Germany)

2000-06-01

The aim of this study was to evaluate the diagnostic potential of virtual endoscopy (VE) and to compare it with axial CT slices, multiplanar reconstructions (MPR), minimal intensity projections (mIP), and bronchoscopy in patients diagnosed with bronchogenic carcinoma. Thirty patients underwent a spiral CT. Axial CT images were transferred to an Onyx workstation (Silicon Graphics, Sun Microsystems, Mountain View, Calif.) for performing virtual endoscopy. Accuracy for this procedure was tested by three radiologists on a monitor in comparison with axial CT slices, MPR, mIP, and bronchoscopy concerning the localization and degree of stenoses. Endoluminal tumors were identified by virtual bronchoscopy with no statistically significant difference of localization or grading of stenosis in comparison with bronchoscopy, axial CT slices, MPR and mIP. Axial CT slices, MPR, and mIP showed poorer results with over- or underestimation of stenoses compared with VE and bronchoscopy. Passing of stenoses was only possible with VE in 5 patients. Virtual endoscopy is a non-invasive method for identification of endoluminal tumors and is comparable to real bronchoscopy. (orig.)

Mathematical Representation of VoIP Connection Delay

Directory of Open Access Journals (Sweden)

M. Halas

2007-09-01

Full Text Available The main topic of this article is to define mathematical formulation of VoIP connection delay model. It handles about all partial delay components, the mechanism of their generation, facilities and their mathematical formulation. Thereafter based on mathematical formulation of all partial delay components, the final mathematical model of whole VoIP call delay is created. In conclusion of this article the results of the designed mathematical model are compared with the experimentally gained results.

The Regulatory Challenges and Opportunities of IP Telephony: Perspective on Malaysia

OpenAIRE

Md Khaled Shukran

2011-01-01

IP telephony is a transmission of voice and data over Packet Switched IP Networks and it has become a key issue in the telecommunication industry worldwide because of its higher efficiency and cheapest call rate. Hence, most of the countries in the world set up their telecommunication platform on IP based network as a fast revenue generating sources. Though Malaysia is on the way forward on IP based platform but the growth is not reached at satisfactory level due to the absence of effective r...

Evaluation and Investigation of the Delay in VoIP Networks

Directory of Open Access Journals (Sweden)

V. Janata

2011-06-01

Full Text Available The paper is focused mainly on the delay problems, which considerably influence the final quality of connections in VoIP (Voice over IP networks. The paper provides a detailed exploration of the nature and mechanisms of the delay. The main purpose of the investigation was an attempt to formulate a mathematical model of delay in the VoIP network and its subsequent analysis by laboratory data.

Modeling ChIP sequencing in silico with applications.

Directory of Open Access Journals (Sweden)

Zhengdong D Zhang

2008-08-01

Full Text Available ChIP sequencing (ChIP-seq is a new method for genomewide mapping of protein binding sites on DNA. It has generated much excitement in functional genomics. To score data and determine adequate sequencing depth, both the genomic background and the binding sites must be properly modeled. To develop a computational foundation to tackle these issues, we first performed a study to characterize the observed statistical nature of this new type of high-throughput data. By linking sequence tags into clusters, we show that there are two components to the distribution of tag counts observed in a number of recent experiments: an initial power-law distribution and a subsequent long right tail. Then we develop in silico ChIP-seq, a computational method to simulate the experimental outcome by placing tags onto the genome according to particular assumed distributions for the actual binding sites and for the background genomic sequence. In contrast to current assumptions, our results show that both the background and the binding sites need to have a markedly nonuniform distribution in order to correctly model the observed ChIP-seq data, with, for instance, the background tag counts modeled by a gamma distribution. On the basis of these results, we extend an existing scoring approach by using a more realistic genomic-background model. This enables us to identify transcription-factor binding sites in ChIP-seq data in a statistically rigorous fashion.

GluN2C/GluN2D subunit-selective NMDA receptor potentiator CIQ reverses MK-801-induced impairment in prepulse inhibition and working memory in Y-maze test in mice

Science.gov (United States)

Suryavanshi, P S; Ugale, R R; Yilmazer-Hanke, D; Stairs, D J; Dravid, S M

2014-01-01

Background and Purpose Despite ample evidence supporting the N-methyl-d-aspartate receptor (NMDAR) hypofunction hypothesis of schizophrenia, progress in the development of effective therapeutics based on this hypothesis has been limited. Facilitation of NMDA receptor function by co-agonists (d-serine or glycine) only partially alleviates the symptoms in schizophrenia; other means to facilitate NMDA receptors are required. NMDA receptor sub-types differ in their subunit composition, with varied GluN2 subunits (GluN2A-GluN2D) imparting different physiological, biochemical and pharmacological properties. CIQ is a positive allosteric modulator that is selective for GluN2C/GluN2D-containing NMDA receptors (Mullasseril et al.). Experimental Approach The effect of systemic administration of CIQ was tested on impairment in prepulse inhibition (PPI), hyperlocomotion and stereotypy induced by i.p. administration of MK-801 and methamphetamine. The effect of CIQ was also tested on MK-801-induced impairment in working memory in Y-maze spontaneous alternation test. Key Results We found that systemic administration of CIQ (20 mg·kg−1, i.p.) in mice reversed MK-801 (0.15 mg·kg−1, i.p.)-induced, but not methamphetamine (3 mg·kg−1, i.p.)-induced, deficit in PPI. MK-801 increased the startle amplitude to pulse alone, which was not reversed by CIQ. In contrast, methamphetamine reduced the startle amplitude to pulse alone, which was reversed by CIQ. CIQ also partially attenuated MK-801- and methamphetamine-induced hyperlocomotion and stereotyped behaviours. Additionally, CIQ reversed the MK-801-induced working memory deficit in spontaneous alternation in a Y-maze. Conclusion and Implications Together, these results suggest that facilitation of GluN2C/GluN2D-containing receptors may serve as an important therapeutic strategy for treating positive and cognitive symptoms in schizophrenia. PMID:24236947

Impacts of dietary calcium, phytate, and nonphytate phosphorus concentrations in the presence or absence of phytase on inositol hexakisphosphate (IP6) degradation in different segments of broilers digestive tract

Science.gov (United States)

Li, W.; Angel, R.; Kim, S.-W.; Brady, K.; Yu, S.; Plumstead, P. W.

2016-01-01

A total of 1,440 straight-run Heritage 56M × fast-feathering Cobb 500F broiler birds were fed from 11 to 13 d of age to determine the impacts of calcium (Ca), phytate phosphorus (PP), nonphytate P (nPP) and phytase concentrations on the myo-inositol hexakisphosphate (IP6) flow through the different parts of gastrointestinal tract (GIT). The experiment was a 2×2×2×3 randomized block design with 2 Ca (0.7 and 1.0%), 2 PP (0.23 and 0.34%), 2 nPP (0.28 and 0.45%) and 3 phytase (0-, 500-, and 1,000-phytase unit (FTU)/kg) concentrations. The experiment was replicated twice (block) with 3 replicates per treatment (Trt) of 10 birds per block. Concentration of IP6 in crop, proventriculus (Prov) plus (+) gizzard (Giz) and distal ileum digesta as well as the ileal IP6 disappearance was determined at 13 d of age. In crop, higher IP6 concentration was seen with increased Ca (P phytase, higher dietary PP led to greater IP6 concentration (P phytase were also seen in Prov+Giz and ileum (P phytase improved IP6 degradation but the degree of impact was dependent on nPP and PP (P phytase inclusion significantly reduced IP6 concentration and IP6 disappearance in distal ileum regardless of GIT segments or diet composition, but impacts of dietary Ca, nPP, and PP differed depending on GIT segment examined. PMID:26740131

Standardization efforts in IP telephony

Science.gov (United States)

Sengodan, Senthil; Bansal, Raj

1999-11-01

The recent interest in IP telephony has led to a tremendous increase of standardization activities in the area. The three main standards bodies in the area of IP telephony are the International Telecommunication Union's (ITU-T) Study Group (SG) 16, the Internet Engineering Task Force (IETF) and the European Telecommunication Standards Institute's (ETSI) TIPHON project. In addition, forums such as the International Multimedia Teleconferencing Consortium (IMTC), the Intelligent Network Forum (INF), the International Softswitch Consortium (ISC), the Electronic Computer Telephony Forum (ECTF), and the MIT's Internet Telephony Consortium (ITC) are looking into various other aspects that aim at the growth of this industry. This paper describes the main tasks (completed and in progress) undertaken by these organizations. In describing such work, an overview of the underlying technology is also provided.

A Reactive and Cycle-True IP Emulator for MPSoC Exploration

DEFF Research Database (Denmark)

Mahadevan, Shankar; Angiolini, Federico; Sparsø, Jens

2008-01-01

The design of MultiProcessor Systems-on-Chip (MPSoC) emphasizes intellectual-property (IP)-based communication-centric approaches. Therefore, for the optimization of the MPSoC interconnect, the designer must develop traffic models that realistically capture the application behavior as executing...... on the IP core. In this paper, we introduce a Reactive IP Emulator (RIPE) that enables an effective emulation of the IP-core behavior in multiple environments, including bit and cycle-true simulation. The RIPE is built as a multithreaded abstract instruction-set processor, and it can generate reactive...

Immunosuppressive effect of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) through the inhibition of T-lymphocyte proliferation and IL-2 production

International Nuclear Information System (INIS)

Yun, Cheol-Heui; Son, Chang Gue; Jung, Uhee; Han, Seung Hyun

2006-01-01

2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is the predominant heterocyclic amine formed in cooked meat and fish and causes cancers in the colon, the mammary glands, and the lymphoid organs. In the present study, we investigated the immunological impact of PhIP using thymocytes isolated from Balb/c mice and a murine thymocyte-derived cell line, EL4. Treatment of the thymocytes with PhIP moderately inhibited T-cell mitogen-induced cell proliferation and interleukin (IL)-2 secretion. Reverse transcription-polymerase chain reaction (RT-PCR) analysis demonstrated that PhIP attenuated IL-2 mRNA expression in the thymocytes and EL4 cells stimulated with phytohemagglutinin (PHA) plus phorbol 12-myristate 13-acetate (PMA). In vitro transient transfection assay using a reporter gene construct containing IL-2 promoter showed that the decrease in the steady-state IL-2 mRNA level by PhIP is partially due to the attenuation of IL-2 mRNA synthesis at the transcriptional level. Furthermore, an electrophoretic mobility shift assay showed that PhIP inhibited DNA binding activity of nuclear factor for immunoglobulin κ chain in B cells (NF-κB), activator protein-1 (AP-1) and nuclear factor of activated T cells (NF-AT), which are known to be responsible for IL-2 transcriptional activation. Concomitantly, PhIP inhibited the PMA/PHA-induced generation of reactive oxygen species (ROS) involved in activation of the transcription factors. These results suggest that PhIP has potential immunosuppressive effects by inhibiting T-cell proliferation and IL-2 expression through down regulation of ROS generation and thereby inhibiting NF-κB, AP-1 and NF-AT activation

Estimating the geoeffectiveness of halo CMEs from associated solar and IP parameters using neural networks

Directory of Open Access Journals (Sweden)

J. Uwamahoro

2012-06-01

Full Text Available Estimating the geoeffectiveness of solar events is of significant importance for space weather modelling and prediction. This paper describes the development of a neural network-based model for estimating the probability occurrence of geomagnetic storms following halo coronal mass ejection (CME and related interplanetary (IP events. This model incorporates both solar and IP variable inputs that characterize geoeffective halo CMEs. Solar inputs include numeric values of the halo CME angular width (AW, the CME speed (Vcme, and the comprehensive flare index (cfi, which represents the flaring activity associated with halo CMEs. IP parameters used as inputs are the numeric peak values of the solar wind speed (Vsw and the southward Z-component of the interplanetary magnetic field (IMF or Bs. IP inputs were considered within a 5-day time window after a halo CME eruption. The neural network (NN model training and testing data sets were constructed based on 1202 halo CMEs (both full and partial halo and their properties observed between 1997 and 2006. The performance of the developed NN model was tested using a validation data set (not part of the training data set covering the years 2000 and 2005. Under the condition of halo CME occurrence, this model could capture 100% of the subsequent intense geomagnetic storms (Dst ≤ −100 nT. For moderate storms (−100 < Dst ≤ −50, the model is successful up to 75%. This model's estimate of the storm occurrence rate from halo CMEs is estimated at a probability of 86%.

RIDES: Robust Intrusion Detection System for IP-Based Ubiquitous Sensor Networks

Directory of Open Access Journals (Sweden)

Sungwon Lee

2009-05-01

Full Text Available TheIP-based Ubiquitous Sensor Network (IP-USN is an effort to build the “Internet of things”. By utilizing IP for low power networks, we can benefit from existing well established tools and technologies of IP networks. Along with many other unresolved issues, securing IP-USN is of great concern for researchers so that future market satisfaction and demands can be met. Without proper security measures, both reactive and proactive, it is hard to envisage an IP-USN realm. In this paper we present a design of an IDS (Intrusion Detection System called RIDES (Robust Intrusion DEtection System for IP-USN. RIDES is a hybrid intrusion detection system, which incorporates both Signature and Anomaly based intrusion detection components. For signature based intrusion detection this paper only discusses the implementation of distributed pattern matching algorithm with the help of signature-code, a dynamically created attack-signature identifier. Other aspects, such as creation of rules are not discussed. On the other hand, for anomaly based detection we propose a scoring classifier based on the SPC (Statistical Process Control technique called CUSUM charts. We also investigate the settings and their effects on the performance of related parameters for both of the components.

Hydroethanolic extract of Carthamus tinctorius induces antidepressant-like effects: modulation by dopaminergic and serotonergic systems in tail suspension test in mice.

Science.gov (United States)

Abbasi-Maleki, Saeid; Mousavi, Zahra

2017-09-01

Studies indicate that major deficiency in the levels of monoaminergic transmitters is a reason for severe depression. On the other hand, it is shown that Carthamus tinctorius L. (CT) may improve neuropsychological injuries by regulation of the monoamine transporter action. Hence, the present study was undertaken to evaluate the involvement of monoaminergic systems in antidepressant-like effect of CT extract in the tail suspension test (TST) in mice. The mice were intraperitoneally (IP) treated with CT extract (100-400 mg/kg) 1 hr before the TST. To investigate the involvement of monoaminergic systems in antidepressant-like effect, the mice were treated with receptor antagonists 15 min before CT extract treatment (400 mg/kg, IP) and 1 hr before the TST. Findings showed that CT extract (100-400 mg/kg, IP), dose-dependently induced antidepressant-like effect ( P open-field test. Pretreatment of mice with SCH23390, sulpiride, haloperidol, WAY100135, cyproheptadine, ketanserin and p-chlorophenylalanine (PCPA) inhibited the antidepressant-like effect of CT extract (400 mg/kg, IP), but not with prazosin and yohimbine. Co-administration of CT extract (100 mg/kg, IP) with sub-effective doses of fluoxetine (5 mg/kg, IP) or imipramine (5 mg/kg, IP) increased their antidepressant-like response. Our findings firstly showed that components (especially N-Hexadecanoic acid) of CT extract induce antidepressant-like effects by interaction with dopaminergic (D1 and D2) and serotonergic (5HT1A, 5-HT2A receptors) systems. These findings validate the folk use of CT extract for the management of depression.

VoIP under the EU regulatory framework : preventing foreclosure?

NARCIS (Netherlands)

Sadowski, B.M.; Straathof, B.

2005-01-01

In June 2004, the European Commission (EC) issued an "Information and Consultation Document" (European Commission 2004) that discussed how the Regulatory Framework of the European Union (EU) should be adapted to accommodate Voice over IP (VoIP) and invited relevant parties to comment on the

On the implementation of IP protection using biometrics based information hiding and firewall

Science.gov (United States)

Basu, Abhishek; Nandy, Kingshuk; Banerjee, Avishek; Giri, Supratick; Sarkar, Souvik; Sarkar, Subir Kumar

2016-02-01

System-on-chip-based design style creates a revolution in very large scale integration industry with design efficiency, operating speed and development time. To support this process, reuse and exchange of components are essential in electronic form called intellectual property (IP). This, however, increases the possibility of encroachment of IP of the design. So copyright protection of IP against piracy is the most important concern for IP vendors. The existing solutions for IP protection are still not secure enough with flexibility, cost, etc. This paper proposes an information-hiding-based solution for IP protection by embedding a biometric copyright information and firewall inside an IP in the form of a finite state machine with unique configuration. The scheme first introduces biometric signature-based copyright as ownership proof. Second, firewall interrupts the normal functionality of IP at the end of the user time period. The experimental outcomes of field-programmable-gate-array implementation illustrate the efficiency of the proposed method.

On the Cryptographic Features of a VoIP Service

Directory of Open Access Journals (Sweden)

Dimitrios Alvanos

2018-01-01

Full Text Available Security issues of typical Voice over Internet Protocol (VoIP applications are studied in this paper; in particular, the open source Linphone application is being used as a case study. An experimental analysis indicates that protecting signalling data with the TLS protocol, which unfortunately is not always the default option, is needed to alleviate several security concerns. Moreover, towards improving security, it is shown that a VoIP application may operate over a virtual private network without significantly degrading the overall performance. The conclusions of this study provide useful insights to the usage of any VoIP application.

Computational Methods for ChIP-seq Data Analysis and Applications

KAUST Repository

Ashoor, Haitham

2017-04-25

The development of Chromatin immunoprecipitation followed by sequencing (ChIP-seq) technology has enabled the construction of genome-wide maps of protein-DNA interaction. Such maps provide information about transcriptional regulation at the epigenetic level (histone modifications and histone variants) and at the level of transcription factor (TF) activity. This dissertation presents novel computational methods for ChIP-seq data analysis and applications. The work of this dissertation addresses four main challenges. First, I address the problem of detecting histone modifications from ChIP-seq cancer samples. The presence of copy number variations (CNVs) in cancer samples results in statistical biases that lead to inaccurate predictions when standard methods are used. To overcome this issue I developed HMCan, a specially designed algorithm to handle ChIP-seq cancer data by accounting for the presence of CNVs. When using ChIP-seq data from cancer cells, HMCan demonstrates unbiased and accurate predictions compared to the standard state of the art methods. Second, I address the problem of identifying changes in histone modifications between two ChIP-seq samples with different genetic backgrounds (for example cancer vs. normal). In addition to CNVs, different antibody efficiency between samples and presence of samples replicates are challenges for this problem. To overcome these issues, I developed the HMCan-diff algorithm as an extension to HMCan. HMCan-diff implements robust normalization methods to address the challenges listed above. HMCan-diff significantly outperforms another state of the art methods on data containing cancer samples. Third, I investigate and analyze predictions of different methods for enhancer prediction based on ChIP-seq data. The analysis shows that predictions generated by different methods are poorly overlapping. To overcome this issue, I developed DENdb, a database that integrates enhancer predictions from different methods. DENdb also

IP over optical multicasting for large-scale video delivery

Science.gov (United States)

Jin, Yaohui; Hu, Weisheng; Sun, Weiqiang; Guo, Wei

2007-11-01

In the IPTV systems, multicasting will play a crucial role in the delivery of high-quality video services, which can significantly improve bandwidth efficiency. However, the scalability and the signal quality of current IPTV can barely compete with the existing broadcast digital TV systems since it is difficult to implement large-scale multicasting with end-to-end guaranteed quality of service (QoS) in packet-switched IP network. China 3TNet project aimed to build a high performance broadband trial network to support large-scale concurrent streaming media and interactive multimedia services. The innovative idea of 3TNet is that an automatic switched optical networks (ASON) with the capability of dynamic point-to-multipoint (P2MP) connections replaces the conventional IP multicasting network in the transport core, while the edge remains an IP multicasting network. In this paper, we will introduce the network architecture and discuss challenges in such IP over Optical multicasting for video delivery.

Photometric studies of δ Scuti stars. I. IP Virginis

Science.gov (United States)

Joner, Michael D.; Hintz, Eric G.; Collier, Matthew W.

1998-01-01

We report 15 new times of maximum light for the δ Scuti star IP Virginis (formerly known as SA 106‐1024). An analysis of all times of maximum light indicates that IP Vir has been decreasing in period at a constant rate of − days day−1. Evidence is also presented that IP Vir is a double‐mode variable with a period ratio of . This period ratio predicts a [Fe/H] value of −0.3. From photometric (uvbyβ) observations, we find a foreground reddening of .008 mag and a metallicity of [Fe/H] = +0.05. It is shown that [Fe/H] = −0.3 is most likely the correct value. Intrinsic ‐ and c1‐values, plotted in a model atmosphere grid, indicate a mean effective temperature, K, and a mean surface gravity, . All of these physical parameters support Landolt's initial conclusion that IP Vir is an ordinary δ Sct star.

Functional-logic simulation of IP-blocks dose functional failures

Directory of Open Access Journals (Sweden)

Vyacheslav M. Barbashov

2017-11-01

Full Text Available The technique of functional-logical simulation of System-on-Chip (SoC total dose radiation failures is presented based on fuzzy logic sets theory. An analysis of the capabilities of this approach for IP-blocks radiation behavior is carried out along with the analysis of operating modes under irradiation influence on IP-blocks radiation behavior. The following elements of this technique application for simulation of dose radiation failures of various types of IP-units are studied: logical elements, memory units and cells, processors. Examples of criterial membership functions and operability functions construction are given for these IP-units and for various critical parameters characterizing their failures. It is shown that when modeling total dose failures it is necessary to take into account the influence of the functional mode on the model parameters. The technique proposed allows improving the reliability of the SoC radiation hardness estimation, also for the purpose of solving the problems of information security of electronic devices.

The psisub(IPS)-LAS relation for extragalactic radio sources

International Nuclear Information System (INIS)

Banhatti, D.G.

1984-01-01

Metre-wavelength interplanetary scintillation (IPS) observations give the overall angular sizes psi of scintillating compact structures in radio sources. From 326.5-MHz IPS data for a sample of faint (Ooty) radio sources, log psi versus log (largest angular size) is seen, on average, to have a slope 0.2, significantly less than one. A similar trend is seen from 81.5-MHz IPS data for a sample of strong, powerful (3CR) double sources, although the slope is 0.4 and the mean psi about four times larger. The difference in slopes is due mainly to the large spread in the redshifts of the 3CR sources compared to the expected narrow range for the Ooty sources, while the difference in mean psi values is due to the different methods of determining psi for the two samples, the different frequencies used for the IPS observations and the different mean LAS values. (author)

CtIP Mutations Cause Seckel and Jawad Syndromes.

Directory of Open Access Journals (Sweden)

Per Qvist

2011-10-01

Full Text Available Seckel syndrome is a recessively inherited dwarfism disorder characterized by microcephaly and a unique head profile. Genetically, it constitutes a heterogeneous condition, with several loci mapped (SCKL1-5 but only three disease genes identified: the ATR, CENPJ, and CEP152 genes that control cellular responses to DNA damage. We previously mapped a Seckel syndrome locus to chromosome 18p11.31-q11.2 (SCKL2. Here, we report two mutations in the CtIP (RBBP8 gene within this locus that result in expression of C-terminally truncated forms of CtIP. We propose that these mutations are the molecular cause of the disease observed in the previously described SCKL2 family and in an additional unrelated family diagnosed with a similar form of congenital microcephaly termed Jawad syndrome. While an exonic frameshift mutation was found in the Jawad family, the SCKL2 family carries a splicing mutation that yields a dominant-negative form of CtIP. Further characterization of cell lines derived from the SCKL2 family revealed defective DNA damage induced formation of single-stranded DNA, a critical co-factor for ATR activation. Accordingly, SCKL2 cells present a lowered apoptopic threshold and hypersensitivity to DNA damage. Notably, over-expression of a comparable truncated CtIP variant in non-Seckel cells recapitulates SCKL2 cellular phenotypes in a dose-dependent manner. This work thus identifies CtIP as a disease gene for Seckel and Jawad syndromes and defines a new type of genetic disease mechanism in which a dominant negative mutation yields a recessively inherited disorder.

Pharmacology of functional endogenous IP prostanoid receptors in NCB-20 cells: comparison with binding data from human platelets.

Science.gov (United States)

Crider, J Y; Xu, S X; Sharif, N A

2001-01-01

The objective of these studies was to characterize the effects of a broad range of prostanoid agonists upon the stimulation of cAMP production in National Cancer Bank (NCB-20; mouse neuroblastoma/hamster brain hybridoma) cells. The pharmacology of these functional responses in NCB-20 cells was compared with that of the classic endogenous IP receptor present on human platelets using [3H]-iloprost binding techniques. In both assay systems, agonists from the IP prostanoid class exhibited the highest affinities and functional potencies. Specific prostanoids exhibited the following rank order of potency (EC50 +/- SEM) in stimulating cAMP production in the NCB-20 cells: carbaprostacyclin (4.3 +/- 0.9 nM) = PGI2 (6.6 +/-1.5 nM) > iloprost (75+/-13 nM) > 11-deoxy PGE, (378+/-138 nM) > misoprostol (1,243+/-48) > PGE2 (3020+/-700 nM) > ZK-118182 (7265+/-455 nM). Iloprost wasthe most potent compound in the human platelet binding assay while prostanoidsfromthe DPand EP receptor classes showed modest affinity. These studies provide functional and binding information for a broad range of both natural and synthetic prostanoid receptor ligands at the endogenous IP receptor in two different cell types.

Internet Protocol-Hybrid Opto-Electronic Ring Network (IP-HORNET): A Novel Internet Protocol-Over-Wavelength Division Multiplexing (IP-Over-WDM) Multiple-Access Metropolitan Area Network (MAN)

Science.gov (United States)

2003-04-01

IP-HORNET, Metropolitan Optical Networks 16. PRICE CODE 17. SECURITY CLASSIFICATION OF REPORT UNCLASSIFIED 18. SECURITY CLASSIFICATION...OF THIS PAGE UNCLASSIFIED 19. SECURITY CLASSIFICATION OF ABSTRACT UNCLASSIFIED 20. LIMITATION OF ABSTRACT UL NSN 7540-01-280-5500...Gemelos, and L. G. Kazovsky, “CSMA/CA MAC protocols for IP-HORNET: An IP over WDM metropolitan area ring netowrk ,” in Proceedings of GLOBE- COM’00

4th CIRP International Conference on Industrial Product-Service Systems

CERN Document Server

Kimita, Koji

2013-01-01

Industrial Product-Service Systems (IPS2), which is defined as “an integrated industrial product and service offering that delivers value in use,” has expanded rapidly over the last decade. IPS2 has allowed us to achieve both high added value and high productivity and has enriched our QOL by improving the performance of products and services. We are now struggling with many awkward issues related to sustainability, but IPS2 is expected to be the “philosopher’s stone” for solving these issues. Following the pattern of conferences held in Cranfield in 2009, Linköping in 2010, and Braunschweig in 2011, the fourth International CIRP Conference on Industrial Product-Service Systems, held on November 8-9, 2012, in Tokyo, will cover various aspects of IPS2. Topics planned for this year’s conference reflect the latest IPS2 information in both the natural sciences and humanities and include case studies from various industries. IPS2 is still a relatively new field, so it is important to keep track of the ...

Enabling IP Header Compression in COTS Routers via Frame Relay on a Simplex Link

Science.gov (United States)

Nguyen, Sam P.; Pang, Jackson; Clare, Loren P.; Cheng, Michael K.

2010-01-01

NASA is moving toward a networkcentric communications architecture and, in particular, is building toward use of Internet Protocol (IP) in space. The use of IP is motivated by its ubiquitous application in many communications networks and in available commercial off-the-shelf (COTS) technology. The Constellation Program intends to fit two or more voice (over IP) channels on both the forward link to, and the return link from, the Orion Crew Exploration Vehicle (CEV) during all mission phases. Efficient bandwidth utilization of the links is key for voice applications. In Voice over IP (VoIP), the IP packets are limited to small sizes to keep voice latency at a minimum. The common voice codec used in VoIP is G.729. This new algorithm produces voice audio at 8 kbps and in packets of 10-milliseconds duration. Constellation has designed the VoIP communications stack to use the combination of IP/UDP/RTP protocols where IP carries a 20-byte header, UDP (User Datagram Protocol) carries an 8-byte header, and RTP (Real Time Transport Protocol) carries a 12-byte header. The protocol headers total 40 bytes and are equal in length to a 40-byte G.729 payload, doubling the VoIP latency. Since much of the IP/UDP/RTP header information does not change from IP packet to IP packet, IP/UDP/RTP header compression can avoid transmission of much redundant data as well as reduce VoIP latency. The benefits of IP header compression are more pronounced at low data rate links such as the forward and return links during CEV launch. IP/UDP/RTP header compression codecs are well supported by many COTS routers. A common interface to the COTS routers is through frame relay. However, enabling IP header compression over frame relay, according to industry standard (Frame Relay IP Header Compression Agreement FRF.20), requires a duplex link and negotiations between the compressor router and the decompressor router. In Constellation, each forward to and return link from the CEV in space is treated

Efficient IP Traffic over Optical Network Based on Wavelength Translation Switching

DEFF Research Database (Denmark)

Jha, Vikas; Kalia, Kartik; Chowdhary, Bhawani Shankar

2016-01-01

With the advent of TCP/IP protocol suite the overall era of communication technologies had been redefined. Now, we can’t ignore the presence of huge amount of IP traffic; data, voice or video increasing day by day creating more pressure on existing communicating media and supporting back bone....... With the humongous popularity of Internet the overall traffic on Internet has the same story. Focusing on transmission of IP traffic in an optical network with signals remaining in their optical nature generated at particular wavelength, proposed is the switching of optically generated IP packets through optical...... cross connects based on translation of wavelength when an IP packet is crossing the optical cross connect. Adding the concepts of layer 3 routing protocols along with the wavelength translation scheme, will help in spanning the overall optical network for a larger area....

Capturing value from IP in a global environment

DEFF Research Database (Denmark)

Alcacer, Juan; Beukel, Karin; Cassiman, Bruno

Executive Summary The authors argue that challenges to capturing value from know-how and reputation through the use of different IP tools will be an increasingly important matter of strategy for global enterprises. This has important implications for management practice. Global enterprises...... will need to combine different institutional, market and non-market mechanisms. The precise combination of tools will depend on the local and regional institutional and market conditions. Abstract: This paper documents the strong growth in tools used by firms to protect their intellectual property (IP......), develop their know-how, and build and maintain their reputation globally during the last decades. We focus on three tools: patents, trademarks, and industrial designs. We find that, although most IP applications come from a few countries (the United States, European Union, Japan, China, and South Korea...

Antimicrobials Products Tested or Pending Testing

Science.gov (United States)

The agency has completed testing of the majority of registered hospital disinfectants and tuberculocide products. The list of products can assist users in making informed choices regarding infection control in their facilities.

Solar Type II Radio Bursts and IP Type II Events

Science.gov (United States)

Cane, H. V.; Erickson, W. C.

2005-01-01

We have examined radio data from the WAVES experiment on the Wind spacecraft in conjunction with ground-based data in order to investigate the relationship between the shocks responsible for metric type II radio bursts and the shocks in front of coronal mass ejections (CMEs). The bow shocks of fast, large CMEs are strong interplanetary (IP) shocks, and the associated radio emissions often consist of single broad bands starting below approx. 4 MHz; such emissions were previously called IP type II events. In contrast, metric type II bursts are usually narrowbanded and display two harmonically related bands. In addition to displaying complete dynamic spectra for a number of events, we also analyze the 135 WAVES 1 - 14 MHz slow-drift time periods in 2001-2003. We find that most of the periods contain multiple phenomena, which we divide into three groups: metric type II extensions, IP type II events, and blobs and bands. About half of the WAVES listings include probable extensions of metric type II radio bursts, but in more than half of these events, there were also other slow-drift features. In the 3 yr study period, there were 31 IP type II events; these were associated with the very fastest CMEs. The most common form of activity in the WAVES events, blobs and bands in the frequency range between 1 and 8 MHz, fall below an envelope consistent with the early signatures of an IP type II event. However, most of this activity lasts only a few tens of minutes, whereas IP type II events last for many hours. In this study we find many examples in the radio data of two shock-like phenomena with different characteristics that occur simultaneously in the metric and decametric/hectometric bands, and no clear example of a metric type II burst that extends continuously down in frequency to become an IP type II event. The simplest interpretation is that metric type II bursts, unlike IP type II events, are not caused by shocks driven in front of CMEs.

The role of calsenilin/DREAM/KChIP3 in contextual fear conditioning.

Science.gov (United States)

Alexander, Jon C; McDermott, Carmel M; Tunur, Tumay; Rands, Vicky; Stelly, Claire; Karhson, Debra; Bowlby, Mark R; An, W Frank; Sweatt, J David; Schrader, Laura A

2009-03-01

Potassium channel interacting proteins (KChIPs) are members of a family of calcium binding proteins that interact with Kv4 potassium (K(+)) channel primary subunits and also act as transcription factors. The Kv4 subunit is a primary K(+) channel pore-forming subunit, which contributes to the somatic and dendritic A-type currents throughout the nervous system. These A-type currents play a key role in the regulation of neuronal excitability and dendritic processing of incoming synaptic information. KChIP3 is also known as calsenilin and as the transcription factor, downstream regulatory element antagonist modulator (DREAM), which regulates a number of genes including prodynorphin. KChIP3 and Kv4 primary channel subunits are highly expressed in hippocampus, an area of the brain important for learning and memory. Through its various functions, KChIP3 may play a role in the regulation of synaptic plasticity and learning and memory. We evaluated the role of KChIP3 in a hippocampus-dependent memory task, contextual fear conditioning. Male KChIP3 knockout (KO) mice showed significantly enhanced memory 24 hours after training as measured by percent freezing. In addition, we found that membrane association and interaction with Kv4.2 of KChIP3 protein was significantly decreased and nuclear KChIP3 expression was increased six hours after the fear conditioning training paradigm with no significant change in KChIP3 mRNA. In addition, prodynorphin mRNA expression was significantly decreased six hours after fear conditioning training in wild-type (WT) but not in KO animals. These data suggest a role for regulation of gene expression by KChIP3/DREAM/calsenilin in consolidation of contextual fear conditioning memories.

Research on TCP/IP network communication based on Node.js

Science.gov (United States)

Huang, Jing; Cai, Lixiong

2018-04-01

In the face of big data, long connection and high synchronization, TCP/IP network communication will cause performance bottlenecks due to its blocking multi-threading service model. This paper presents a method of TCP/IP network communication protocol based on Node.js. On the basis of analyzing the characteristics of Node.js architecture and asynchronous non-blocking I/O model, the principle of its efficiency is discussed, and then compare and analyze the network communication model of TCP/IP protocol to expound the reasons why TCP/IP protocol stack is widely used in network communication. Finally, according to the large data and high concurrency in the large-scale grape growing environment monitoring process, a TCP server design based on Node.js is completed. The results show that the example runs stably and efficiently.

MICROSOFT DYNAMICS CRM IN CISCO IP TELEFONIJA

OpenAIRE

Knez, Margareta

2011-01-01

Microsoft Dynamics CRM je le ena od mnogih rešitev CRM, ki se iz dneva v dan bolj izpopolnjuje in postaja prijaznejša za uporabnike. Na trgu je še mnogo drugih konkurenčnih rešitev programskega orodja CRM. Tako je tudi Ciscova IP-telefonija le ena od mnogih ponudnikov te tehnologije. IP-telefonija bo počasi spodrinila navadno telefonsko linijo, saj je veliko cenejša in ponuja še mnogo dodatnih funkcionalnosti. Le lepa beseda in dobra komunikacija sta potrebni, da stranko zadovoljimo in...

Elevated OPN, IP-10, and Neutrophilia in Loop-Mediated Isothermal Amplification Confirmed Tuberculosis Patients

Directory of Open Access Journals (Sweden)

Beata Shiratori

2014-01-01

Full Text Available Tuberculosis (TB is the second most common cause of death from infectious diseases and results in high socioeconomic losses to many countries. Proper diagnosis is the first step in TB eradication. To develop a rapid, simple, and accurate diagnostic TB test and to characterize the prevalence of Mycobacterium tuberculosis (MTB genotypes and immune profiles of TB patients, a total of 37 TB patients and 30 healthy control (HC from Metro Manila were enrolled. Loop-mediated isothermal amplification (LAMP reliably detected MTB infection. Manila genotype was identified by spoligotyping method in all TB patients. Osteopontin (OPN, interferon-γ-induced protein 10 kDa (IP-10, and neutrophil counts were found to reflect the acute stage of MTB infection. The sensitivity and specificity were 94.6% and 93.3%, respectively, for both OPN and IP-10, and they were 83.8% and 78.6%, respectively, for neutrophils. The combination of OPN, IP-10, neutrophil count, IL-6, IL-8, TNF-α, MCP-1, platelets, galectin-9, and leukocyte count correctly identifies all the HC and 96.3% of TB patients. LAMP method may serve as a rapid, supportive method in addition to time-consuming culture methods. OPN, IP-10, and neutrophil counts are useful in detecting MTB infection and may have utility in monitoring the course of the disease.

University Faculty and the Value of Their Intellectual Property: Comparing IP in Teaching and Research

Science.gov (United States)

Hentschke, Guilbert C.

2017-01-01

This chapter describes the protectionist and access functions of intellectual property for the teaching and research work of university faculty. The degree to which an individual piece of IP is protected or made accessible to others depends in large measure on its market-related characteristics, including costs of production, availability of…

A Novel Addressing Scheme for PMIPv6 Based Global IP-WSNs

Directory of Open Access Journals (Sweden)

Md. Motaharul Islam

2011-08-01

Full Text Available IP based Wireless Sensor Networks (IP-WSNs are being used in healthcare, home automation, industrial control and agricultural monitoring. In most of these applications global addressing of individual IP-WSN nodes and layer-three routing for mobility enabled IP-WSN with special attention to reliability, energy efficiency and end to end delay minimization are a few of the major issues to be addressed. Most of the routing protocols in WSN are based on layer-two approaches. For reliability and end to end communication enhancement the necessity of layer-three routing for IP-WSNs is generating significant attention among the research community, but due to the hurdle of maintaining routing state and other communication overhead, it was not possible to introduce a layer-three routing protocol for IP-WSNs. To address this issue we propose in this paper a global addressing scheme and layer-three based hierarchical routing protocol. The proposed addressing and routing approach focuses on all the above mentioned issues. Simulation results show that the proposed addressing and routing approach significantly enhances the reliability, energy efficiency and end to end delay minimization. We also present architecture, message formats and different routing scenarios in this paper.

A novel addressing scheme for PMIPv6 based global IP-WSNs.

Science.gov (United States)

Islam, Md Motaharul; Huh, Eui-Nam

2011-01-01

IP based Wireless Sensor Networks (IP-WSNs) are being used in healthcare, home automation, industrial control and agricultural monitoring. In most of these applications global addressing of individual IP-WSN nodes and layer-three routing for mobility enabled IP-WSN with special attention to reliability, energy efficiency and end to end delay minimization are a few of the major issues to be addressed. Most of the routing protocols in WSN are based on layer-two approaches. For reliability and end to end communication enhancement the necessity of layer-three routing for IP-WSNs is generating significant attention among the research community, but due to the hurdle of maintaining routing state and other communication overhead, it was not possible to introduce a layer-three routing protocol for IP-WSNs. To address this issue we propose in this paper a global addressing scheme and layer-three based hierarchical routing protocol. The proposed addressing and routing approach focuses on all the above mentioned issues. Simulation results show that the proposed addressing and routing approach significantly enhances the reliability, energy efficiency and end to end delay minimization. We also present architecture, message formats and different routing scenarios in this paper.

Aspects of the epidemiology of intestinal parasitosis (IP) in children ...

African Journals Online (AJOL)

Aspects of the epidemiology of intestinal parasitosis (IP) in children: ... Conclusion: The low level of knowledge, practices and perceptions of mothers concerning IP is a major cause for ... EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT

An IP-oriented 11-bit 160 MS/s 2-channel current-steering DAC

International Nuclear Information System (INIS)

Xu Ning; Li Fule; Zhang Chun; Wang Zhihua

2014-01-01

This paper presents an 11-bit 160 MS/s 2-channel current-steering digital-to-analog converter (DAC) IP. The circuit and layout are carefully designed to optimize its performance and area. A 6-2-3 segmented structure is used for the trade-off among linearity, area and layout complexity. The sizes of current source transistors are calculated out according to the process matching parameter. The unary current cells are placed in a one-dimension distribution to simplify the layout routing, spare area and wiring layer. Their sequences are also carefully designed to reduce integral nonlinearity. The test result presents an SFDR of 72 dBc at 4.88 MHz input signal with DNL ⩽ 0.25 LSB, INL ⩽ 0.8 LSB. The full-scale output current is 5 mA with a 2.5 V analog power supply. The core of each channel occupies 0.08 mm 2 in a 1P-8M 55 nm CMOS process. (semiconductor integrated circuits)

TNP [N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine] ameliorates diet induced obesity and insulin resistance via inhibition of the IP6K1 pathway.

Science.gov (United States)

Ghoshal, Sarbani; Zhu, Qingzhang; Asteian, Alice; Lin, Hua; Xu, Haifei; Ernst, Glen; Barrow, James C; Xu, Baoji; Cameron, Michael D; Kamenecka, Theodore M; Chakraborty, Anutosh

2016-10-01

Obesity and type 2 diabetes (T2D) lead to various life-threatening diseases such as coronary heart disease, stroke, osteoarthritis, asthma, and neurodegeneration. Therefore, extensive research is ongoing to identify novel pathways that can be targeted in obesity/T2D. Deletion of the inositol pyrophosphate (5-IP7) biosynthetic enzyme, inositol hexakisphosphate kinase-1 (IP6K1), protects mice from high fat diet (HFD) induced obesity (DIO) and insulin resistance. Yet, whether this pathway is a valid pharmacologic target in obesity/T2D is not known. Here, we demonstrate that TNP [N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine], a pan-IP6K inhibitor, has strong anti-obesity and anti-diabetic effects in DIO mice. Q-NMR, GTT, ITT, food intake, energy expenditure, QRT-PCR, ELISA, histology, and immunoblot studies were conducted in short (2.5-week)- and long (10-week)-term TNP treated DIO C57/BL6 WT and IP6K1-KO mice, under various diet and temperature conditions. TNP, when injected at the onset of HFD-feeding, decelerates initiation of DIO and insulin resistance. Moreover, TNP facilitates weight loss and restores metabolic parameters, when given to DIO mice. However, TNP does not reduce weight gain in HFD-fed IP6K1-KO mice. TNP specifically enhances insulin sensitivity in DIO mice via Akt activation. TNP decelerates weight gain primarily by enhancing thermogenic energy expenditure in the adipose tissue. Accordingly, TNP's effect on body weight is partly abolished whereas its impact on glucose homeostasis is preserved at thermoneutral temperature. Pharmacologic inhibition of the inositol pyrophosphate pathway has strong therapeutic potential in obesity, T2D, and other metabolic diseases.

R&D productivity rides again?

Science.gov (United States)

Lendrem, Dennis; Senn, Stephen J; Lendrem, B Clare; Isaacs, John D

2015-01-01

A recent analysis of R&D productivity suggests that there are grounds for 'cautious optimism' that the industry 'turned the corner' in 2008 and is 'on the comeback trail'. We believe that this analysis is flawed and most probably wrong. We present an alternative analysis of these same data to suggest that the industry is not yet 'out of the woods' and suggest that many of the systemic issues affecting pharmaceutical R&D productivity are still being resolved. Copyright © 2014 John Wiley & Sons, Ltd.

Identification of myo-inositol hexakisphosphate (IP6) as a β-secretase 1 (BACE1) inhibitory molecule in rice grain extract and digest.

Science.gov (United States)

Abe, Takako K; Taniguchi, Masayuki

2014-01-01

Alzheimer's disease (AD) is widely considered to be caused by amyloid-β peptide (Aβ) accumulation in the brain. Aβ is excised from amyloid-β precursor protein through sequential cleavage by β-secretase 1 (BACE1) and γ-secretase. Thus, BACE1 inhibition could prevent Aβ accumulation. Here, we identified myo-inositol hexakisphosphate (IP6) as a BACE1 inhibitory molecule in rice grain extract and digest. The rice digest and IP6 significantly inhibited Aβ production in neuroblastoma cells without cytotoxicity. These results suggested that rice components, including IP6, may be promising starting materials for the development of potent and safe drugs and/or food to prevent AD.

Clinical Diagnostic Utility of IP-10 and LAM Antigen Levels for the Diagnosis of Tuberculous Pleural Effusions in a High Burden Setting

Science.gov (United States)

Dheda, Keertan; Van-Zyl Smit, Richard N.; Sechi, Leonardo A.; Badri, Motasim; Meldau, Richard; Symons, Gregory; Khalfey, Hoosein; Carr, Igshaan; Maredza, Alice; Dawson, Rodney; Wainright, Helen; Whitelaw, Andrew; Bateman, Eric D.; Zumla, Alimuddin

2009-01-01

Background Current tools for the diagnosis of tuberculosis pleural effusions are sub-optimal. Data about the value of new diagnostic technologies are limited, particularly, in high burden settings. Preliminary case control studies have identified IFN-γ-inducible-10kDa protein (IP-10) as a promising diagnostic marker; however, its diagnostic utility in a day-to-day clinical setting is unclear. Detection of LAM antigen has not previously been evaluated in pleural fluid. Methods We investigated the comparative diagnostic utility of established (adenosine deaminase [ADA]), more recent (standardized nucleic-acid-amplification-test [NAAT]) and newer technologies (a standardized LAM mycobacterial antigen-detection assay and IP-10 levels) for the evaluation of pleural effusions in 78 consecutively recruited South African tuberculosis suspects. All consenting participants underwent pleural biopsy unless contra-indicated or refused. The reference standard comprised culture positivity for M. tuberculosis or histology suggestive of tuberculosis. Principal Findings Of 74 evaluable subjects 48, 7 and 19 had definite, probable and non-TB, respectively. IP-10 levels were significantly higher in TB vs non-TB participants (p<0.0001). The respective outcomes [sensitivity, specificity, PPV, NPV %] for the different diagnostic modalities were: ADA at the 30 IU/L cut-point [96; 69; 90; 85], NAAT [6; 93; 67; 28], IP-10 at the 28,170 pg/ml ROC-derived cut-point [80; 82; 91; 64], and IP-10 at the 4035 pg/ml cut-point [100; 53; 83; 100]. Thus IP-10, using the ROC-derived cut-point, missed ∼20% of TB cases and mis-diagnosed ∼20% of non-TB cases. By contrast, when a lower cut-point was used a negative test excluded TB. The NAAT had a poor sensitivity but high specificity. LAM antigen-detection was not diagnostically useful. Conclusion Although IP-10, like ADA, has sub-optimal specificity, it may be a clinically useful rule-out test for tuberculous pleural effusions. Larger multi

76 FR 81955 - Assessment Questionnaire-IP Sector Specific Agency Risk Self Assessment Tool (IP-SSARSAT)

Science.gov (United States)

2011-12-29

... DEPARTMENT OF HOMELAND SECURITY [Docket No. DHS-2011-0069] Assessment Questionnaire--IP Sector... will be posted without alteration at http://www.regulations.gov , including any personal information... managers often volunteer to conduct an automated self risk assessment. The requested questionnaire...

77 FR 3559 - Energy Conservation Program for Consumer Products: Test Procedures for Refrigerators...

Science.gov (United States)

2012-01-25

... Long-Time and Variable Defrost Test Method To Fully Capture Energy Use for Temperature Recovery D... product classes. 55 FR 42845 (October 24, 1990). DOE again updated the performance standards for...: (1) Compartment temperature changes; (2) modified volume calculation methods; (3) products that...

Searching CLEF-IP by Strategy

NARCIS (Netherlands)

W. Alink (Wouter); R. Cornacchia (Roberto); A.P. de Vries (Arjen)

2010-01-01

htmlabstractTasks performed by intellectual property specialists are often ad hoc, and continuously require new approaches to search a collection of documents. We therefore investigate the benets of a visual `search strategy builder' to allow IP search experts to express their approach to

Production of 14 MeV neutrons from D-D neutron generators

International Nuclear Information System (INIS)

Cecil, F.E.; Nieschmidt, E.B.

1986-01-01

The production of 14 MeV neutrons from a D-D neutron generator resulting from tritium buildup from the d(d,p)t reaction in the target is discussed. The effect of the 14 MeV neutrons on fast neutron activation analysis with D-D neutron generators is evaluated. (orig.)

Single-tube linear DNA amplification (LinDA) for robust ChIP-seq

NARCIS (Netherlands)

Shankaranarayanan, P.; Mendoza-Parra, M.A.; Walia, M.; Wang, L.; Li, N.; Trindade, L.M.; Gronemeyer, H.

2011-01-01

Genome-wide profiling of transcription factors based on massive parallel sequencing of immunoprecipitated chromatin (ChIP-seq) requires nanogram amounts of DNA. Here we describe a high-fidelity, single-tube linear DNA amplification method (LinDA) for ChIP-seq and reChIP-seq with picogram DNA amounts

A Novel Smart Meter Controlling System with Dynamic IP Addresses

DEFF Research Database (Denmark)

Manembu, Pinrolinvic; Welang, Brammy; Kalua Lapu, Aditya

2017-01-01

Smart meters are the electronic devices for measuring energy consumption in real time. Usually, static public IP addresses are allocated to realize the point-to-point (P2P) communication and remote controlling for smart metering systems. This, however, restricts the wide deployment of smart meters......, due to the deficiency of public IP resources. This paper proposes a novel subscription-based communication architecture for the support of dynamic IP addresses and group controlling of smart meters. The paper evaluates the proposed architecture by comparing the traditional P2P architecture...

OSI and TCP/IP

Science.gov (United States)

Randolph, Lynwood P.

1994-01-01

The Open Systems Interconnection Transmission Control Protocol/Internet Protocol (OSI TCP/IP) and the Government Open Systems Interconnection Profile (GOSIP) are compared and described in terms of Federal internetworking. The organization and functions of the Federal Internetworking Requirements Panel (FIRP) are discussed and the panel's conclusions and recommendations with respect to the standards and implementation of the National Information Infrastructure (NII) are presented.

Quantitative ChIP-Seq Normalization Reveals Global Modulation of the Epigenome

Directory of Open Access Journals (Sweden)

David A. Orlando

2014-11-01

Full Text Available Epigenomic profiling by chromatin immunoprecipitation coupled with massively parallel DNA sequencing (ChIP-seq is a prevailing methodology used to investigate chromatin-based regulation in biological systems such as human disease, but the lack of an empirical methodology to enable normalization among experiments has limited the precision and usefulness of this technique. Here, we describe a method called ChIP with reference exogenous genome (ChIP-Rx that allows one to perform genome-wide quantitative comparisons of histone modification status across cell populations using defined quantities of a reference epigenome. ChIP-Rx enables the discovery and quantification of dynamic epigenomic profiles across mammalian cells that would otherwise remain hidden using traditional normalization methods. We demonstrate the utility of this method for measuring epigenomic changes following chemical perturbations and show how reference normalization of ChIP-seq experiments enables the discovery of disease-relevant changes in histone modification occupancy.

Short-term carcinogenicity testing of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) and 2-amino-3-methylimidazo[4,5-f] quinoline (IQ) in E mu-pim-1 transgenic mice

DEFF Research Database (Denmark)

Sørensen, Ilona Kryspin; Mortensen, Alicja; Kristiansen, E.

1996-01-01

The usefulness of transgenic E mu-pim-1 mice over-expressing the pim-1 oncogene in lymphoid tissues, as sensitive test organisms was studied in a short-term carcinogenicity study. The mice were fed standard diet Altromin 1314 supplemented either with 0.03% 2-amino-1-methyl-6-phenylimidazo[4,5-b......]pyridine (PhIP) for 7 months or with 0.03% 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) for 6 months, PhIP and IQ are heterocyclic amines formed during cooking of meat and fish and are mutagenic to bacteria and cultured mammalian cells, PhIP is a potent mouse lymphomagen, while IQ is a liver carcinogen...... to non-transgenic mice. Our results suggest that the transgenic E mu-pim-1 mouse may be a useful model for short-term carcinogenicity screening of potential genotoxic carcinogens having the lymphoid system as target tissue, The carcinogen IQ which does not have the lymphoid system as a target...

The Acute Administration of the Selective Dopamine D3 Receptor Antagonist SB-277011A Reverses Conditioned Place Aversion Produced by Naloxone Precipitated Withdrawal From Acute Morphine Administration in Rats

Science.gov (United States)

RICE, ONARAE V.; GARDNER, ELIOT L.; HEIDBREDER, CHRISTIAN A.; ASHBY, CHARLES R.

2014-01-01

We examined the effect of SB-277011A, a selective D3 receptor antagonist, on the conditioned place aversion (CPA) response associated with naloxone-induced withdrawal from acute morphine administration in male Sprague-Dawley rats. Morphine (5.6 mg/kg i.p.) was given, followed 4 hrs later by naloxone (0.3 mg/kg i.p.) and prior to placing the animals in one specific chamber of the test apparatus. All animals were subjected to 2 of these trials. A significant CPA occurred in animals that received an i.p. injection of vehicle 30 minutes prior to the measurement of chamber preference. The pretreatment of animals (30 minutes prior to testing) with 3 mg/kg i.p. of SB-277011A did not significantly alter the CPA compared to animals treated with vehicle (1 ml/kg i.p. of deionized distilled water). In contrast, the acute pretreatment of animals with 6, 12 or 24 mg/kg i.p. of SB-277011A significantly decreased the CPA compared to vehicle-treated animals. In fact, the 12 and 24 mg/kg doses of SB-277011A significantly increased the time spent in the chamber where animals were paired with morphine and naloxone. These results suggest that the selective antagonism of D3 receptors attenuates the CPA produced by a model of naloxone-induced withdrawal from acute morphine dependence. PMID:21905128

Real-time services in IP network architectures

Science.gov (United States)

Gilardi, Antonella

1996-12-01

The worldwide internet system seems to be the success key for the provision of real time multimedia services to both residential and business users and someone says that in such a way broadband networks will have a reason to exist. This new class of applications that use multiple media (voice, video and data) impose constraints to the global network nowadays consisting of subnets with various data links. The attention will be focused on the interconnection of IP non ATM and ATM networks. IETF and ATM forum are currently involved in the developing specifications suited to adapt the connectionless IP protocol to the connection oriented ATM protocol. First of all the link between the ATM and the IP service model has to be set in order to match the QoS and traffic requirements defined in the relative environment. A further significant topic is represented by the mapping of IP resource reservation model onto the ATM signalling and in the end it is necessary to define how the routing works when there are QoS parameters associated. This paper, considering only unicast applications, will examine the above issues taking as a starting point the situation where an host launches as call set up request with the relevant QoS and traffic descriptor and at some point a router at the edge of the ATM network has to decide how forwarding and request in order to establish an end to end link with the right capabilities. The aim is to compare the proposals emerging from different standard bodies to point out convergency or incompatibility.

The Incredibly Long-Lived SN 2005ip

Science.gov (United States)

Fox, Ori

2016-10-01

Type IIn supernovae (SNe IIn) are defined by their relatively narrow spectral line features associated with a dense circumstellar medium (CSM) formed by the progenitor star. The nature of the progenitor and mass loss remains relatively unknown. Shock interaction with the dense CSM can often result in significant UV emission for several years post-explosion, thereby probing the CSM characteristics, progenitor mass loss history and, ultimately, the progenitor itself. The Type IIn SN 2005ip proves to be one of the most interesting and well-studied targets within this subclass. Compared to all other supernovae, SN 2005ip is the most luminous for its age. Now more than 11 years post-explosion, the SN has released >10^51 erg throughout its lifetime as the forward shock continues to collide with a dense CSM. Here we propose HST/STIS-MAMA UV observations of SN 2005ip to investigate the massive CSM. When accounting for the shock travel time, these observations will probe material lost from the progenitor more than 1000 years prior to the explosion. We already have a single HST/STIS spectrum of SN 2005ip from 2014, which was obtained while the shock was still within a higher mass regime. With just 5 orbits, a second spectrum will allow us to directly trace the evolution of the CSM and produce new constraints on the pre-SN mass-loss history. Coinciding with Cycle 24's UV Initiative, this program offers new insight regarding both the progenitor and explosion characteristics of the SN IIn subclass.

Sate-of-the-art IP switching router architecture using SFQ technology

International Nuclear Information System (INIS)

Miyaho, N.; Miyahara, K.; Yamazaki, A.

2006-01-01

Taking the recent trend of rapid IP traffic increasing and QoS in the Internet into account, we propose an innovative IP router architecture from the viewpoint of minimum switching delay, switching capacity, QoS assurance for the next generation Internet services. We examined the IP router performance using superconductivity device simulator (WinS) assuming the future-generation Nb junction process and confirmed more than 300 GHz clock operation. For the evaluation of a novel IP switch architecture, we effectively apply the SFQ circuits using Josephson junctions to an extremely restricted function block in the switching node and a conventional semiconductor technology is also applied for the rest parts of the other function blocks inside it

Network analysis of ChIP-Seq data reveals key genes in prostate cancer.

Science.gov (United States)

Zhang, Yu; Huang, Zhen; Zhu, Zhiqiang; Liu, Jianwei; Zheng, Xin; Zhang, Yuhai

2014-09-03

Prostate cancer (PC) is the second most common cancer among men in the United States, and it imposes a considerable threat to human health. A deep understanding of its underlying molecular mechanisms is the premise for developing effective targeted therapies. Recently, deep transcriptional sequencing has been used as an effective genomic assay to obtain insights into diseases and may be helpful in the study of PC. In present study, ChIP-Seq data for PC and normal samples were compared, and differential peaks identified, based upon fold changes (with P-values calculated with t-tests). Annotations of these peaks were performed. Protein-protein interaction (PPI) network analysis was performed with BioGRID and constructed with Cytoscape, following which the highly connected genes were screened. We obtained a total of 5,570 differential peaks, including 3,726 differentially enriched peaks in tumor samples and 1,844 differentially enriched peaks in normal samples. There were eight significant regions of the peaks. The intergenic region possessed the highest score (51%), followed by intronic (31%) and exonic (11%) regions. The analysis revealed the top 35 highly connected genes, which comprised 33 differential genes (such as YWHAQ, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein and θ polypeptide) from ChIP-Seq data and 2 differential genes retrieved from the PPI network: UBA52 (ubiquitin A-52 residue ribosomal protein fusion product (1) and SUMO2 (SMT3 suppressor of mif two 3 homolog (2) . Our findings regarding potential PC-related genes increase the understanding of PC and provides direction for future research.

Implantación de switching y ToIP sobre una red WAN

OpenAIRE

Pique Palacin, Ivan

2013-01-01

Este proyecto tiene como objeto el diseño y la implementación de servicios de comunicaciones de LAN (Switching) y Telefonía IP (ToIP), todos ellos integrados sobre una red WAN nacional ya existente y funcionando, gestionada por un ISP. Aquest projecte té com a objecte el disseny i la implementació de serveis de comunicacions de LAN (Switching) i telefonia IP (ToIP), tots ells integrats sobre una xarxa WAN nacional ja existent i funcionant, gestionada per un ISP. Bachelor thesis for the ...

LMIP/AAA: Local Authentication, Authorization and Accounting (AAA) Protocol for Mobile IP

Science.gov (United States)

Chenait, Manel

Mobile IP represents a simple and scalable global mobility solution. However, it inhibits various vulnerabilities to malicious attacks and, therefore, requires the integration of appropriate security services. In this paper, we discuss two authentication schemes suggested for Mobile IP: standard authentication and Mobile IP/AAA authentication. In order to provide Mobile IP roaming services including identity verication, we propose an improvement to Mobile/AAA authentication scheme by applying a local politic key management in each domain, hence we reduce hando latency by avoiding the involvement of AAA infrastructure during mobile node roaming.

Controlling applied to information processing: quality management applied to IP projects and IP services; Informationsverarbeitungs-Controlling: Qualitaetsmanagement fuer IV-Projekte und fuer IV-Service

Energy Technology Data Exchange (ETDEWEB)

Becker, B. [Vereinigung Deutscher Elektrizitaetswerke e.V. (VDEW), Frankfurt am Main (Germany); Beckers, F. [Isar-Amperwerke AG, Muenchen (Germany); Dewald, N. [Bayernwerk AG, Muenchen (Germany); Hauffe, P. [Pfalzwerke AG, Ludwigshafen am Rhein (Germany); Hein, F. [EVS AG Stuttgart (Germany); Hoederath, M. [Vereinigte Elektrizitaetswerke Westfalen AG (VEW), Dortmund (Germany); Seyen, R. [Staedtische Werke Nuernberg GmbH (Germany)

1998-01-12

The working group on information processing (IP) basics (in German: `IV-Grundlagen`) has prepared this contribution dealing with controlling applied to information processing. This new report, on the one hand, takes into consideration the role of the organizational IP unit as one offering its services to all sections of a company. On the other hand, information processing as an operational infrastructure influencing all business processes becomes increasingly important with respect to the competitiveness of the EVU. Therefore, quality management applied to IP projects and IP services must support this development. (orig./RHM) [Deutsch] Der VDEW Arbeitskreis `IV-Grundlagen` hat einen Beitrag zum Controlling fuer die Informationsverarbeitung erstellt. Hier geht zum einen die Rolle der Organisationseinheit IV als Dienstleister fuer alle Unternehmensbereiche ein. Zum anderen gewinnt die Informationsverarbeitung als betriebliche Infrastruktur fuer alle Geschaeftsprozesse zunehmende Bedeutung fuer die Wettbewerbsfaehigkeit der EVU. Das Qualitaetsmanagement fuer IV-Projekte und fuer IV-Service muss dies unterstuetzen. (orig./RHM)

Practical guidelines for the comprehensive analysis of ChIP-seq data.

Directory of Open Access Journals (Sweden)

Timothy Bailey

Full Text Available Mapping the chromosomal locations of transcription factors, nucleosomes, histone modifications, chromatin remodeling enzymes, chaperones, and polymerases is one of the key tasks of modern biology, as evidenced by the Encyclopedia of DNA Elements (ENCODE Project. To this end, chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq is the standard methodology. Mapping such protein-DNA interactions in vivo using ChIP-seq presents multiple challenges not only in sample preparation and sequencing but also for computational analysis. Here, we present step-by-step guidelines for the computational analysis of ChIP-seq data. We address all the major steps in the analysis of ChIP-seq data: sequencing depth selection, quality checking, mapping, data normalization, assessment of reproducibility, peak calling, differential binding analysis, controlling the false discovery rate, peak annotation, visualization, and motif analysis. At each step in our guidelines we discuss some of the software tools most frequently used. We also highlight the challenges and problems associated with each step in ChIP-seq data analysis. We present a concise workflow for the analysis of ChIP-seq data in Figure 1 that complements and expands on the recommendations of the ENCODE and modENCODE projects. Each step in the workflow is described in detail in the following sections.

The extended TRIP supporting VoIP routing reservation with distributed QoS

Science.gov (United States)

Wang, Furong; Wu, Ye

2004-04-01

In this paper, an existing protocol, i.e. TRIP (Telephony Routing over IP) is developed to provide distributed QoS when making resource reservations for VoIP services such as H.323, SIP. Enhanced LSs (location servers) are deployed in ITADs (IP Telephony Administrative Domains) to take in charge of intra-domain routing policy because of small propagation price. It is an easy way to find an IP telephone route for intra-domain VoIP media association and simultaneously possess intra-domain load balancing features. For those routing reservations bridging domains, inter-domain routing policy is responsible for finding the shortest inter-domain route with enough resources. I propose the routing preference policy based on QoS price when the session traffic is shaped by a token bucket, related QoS messages, and message cooperation.

Anti-Aβ drug screening platform using human iPS cell-derived neurons for the treatment of Alzheimer's disease.

Directory of Open Access Journals (Sweden)

Naoki Yahata

Full Text Available BACKGROUND: Alzheimer's disease (AD is a neurodegenerative disorder that causes progressive memory and cognitive decline during middle to late adult life. The AD brain is characterized by deposition of amyloid β peptide (Aβ, which is produced from amyloid precursor protein by β- and γ-secretase (presenilin complex-mediated sequential cleavage. Induced pluripotent stem (iPS cells potentially provide an opportunity to generate a human cell-based model of AD that would be crucial for drug discovery as well as for investigating mechanisms of the disease. METHODOLOGY/PRINCIPAL FINDINGS: We differentiated human iPS (hiPS cells into neuronal cells expressing the forebrain marker, Foxg1, and the neocortical markers, Cux1, Satb2, Ctip2, and Tbr1. The iPS cell-derived neuronal cells also expressed amyloid precursor protein, β-secretase, and γ-secretase components, and were capable of secreting Aβ into the conditioned media. Aβ production was inhibited by β-secretase inhibitor, γ-secretase inhibitor (GSI, and an NSAID; however, there were different susceptibilities to all three drugs between early and late differentiation stages. At the early differentiation stage, GSI treatment caused a fast increase at lower dose (Aβ surge and drastic decline of Aβ production. CONCLUSIONS/SIGNIFICANCE: These results indicate that the hiPS cell-derived neuronal cells express functional β- and γ-secretases involved in Aβ production; however, anti-Aβ drug screening using these hiPS cell-derived neuronal cells requires sufficient neuronal differentiation.

Testing nonlinear-QED at the future linear collider with an intense laser

International Nuclear Information System (INIS)

Hartin, Anthony; Porto, Stefano; Moortgat-Pick, Gudrid; Hamburg Univ.

2014-04-01

The future linear collider will collide dense e + e - bunches at high energies up to 1 TeV, generating very intense electromagnetic fields at the interaction point (IP). These fields are strong enough to lead to nonlinear effects which affect all IP processes and which are described by strong field physics theory. In order to test this theory, we propose an experiment that will focus an intense laser on the LC electron beam post-IP. Similar experiments at SLAC E144 have investigated nonlinear Compton scattering, Breit-Wheeler pair production using an electron beam of 46.6 GeV. The higher beam energies available at the future LC would allow more precise studies of these phenomena. Mass-shift and spin-dependent effects could also be investigated.

Longevity and clinical performance of IPS-Empress ceramic restorations--a literature review.

Science.gov (United States)

El-Mowafy, Omar; Brochu, Jean-François

2002-04-01

A literature review of longevity and clinical performance of IPS-Empress restorations is presented. A MEDLINE search was conducted in fall 2000. Selection criteria were set so as to identify suitable clinical trials that were published in full and that had lasted more than 2 years. A total of 6 clinical trials on the performance of IPS-Empress inlays and onlays and a total of 3 clinical trials on the performance of IPS-Empress crowns were identified. Survival rates for IPS-Empress inlays and onlays ranged from 96% at 4.5 years to 91% at 7 years; most failures were due to bulk fracture. IPS-Empress crowns had a survival rate ranging from 92% to 99% at 3 to 3.5 years; crown failure was also mainly due to fracture. Dentists should inform their patients about these survival rates when offering such treatment. The use of IPS-Empress crowns in the posterior of the mouth is not recommended until the results of more long-term clinical trials are available.

Data exploration, quality control and statistical analysis of ChIP-exo/nexus experiments.

Science.gov (United States)

Welch, Rene; Chung, Dongjun; Grass, Jeffrey; Landick, Robert; Keles, Sündüz

2017-09-06

ChIP-exo/nexus experiments rely on innovative modifications of the commonly used ChIP-seq protocol for high resolution mapping of transcription factor binding sites. Although many aspects of the ChIP-exo data analysis are similar to those of ChIP-seq, these high throughput experiments pose a number of unique quality control and analysis challenges. We develop a novel statistical quality control pipeline and accompanying R/Bioconductor package, ChIPexoQual, to enable exploration and analysis of ChIP-exo and related experiments. ChIPexoQual evaluates a number of key issues including strand imbalance, library complexity, and signal enrichment of data. Assessment of these features are facilitated through diagnostic plots and summary statistics computed over regions of the genome with varying levels of coverage. We evaluated our QC pipeline with both large collections of public ChIP-exo/nexus data and multiple, new ChIP-exo datasets from Escherichia coli. ChIPexoQual analysis of these datasets resulted in guidelines for using these QC metrics across a wide range of sequencing depths and provided further insights for modelling ChIP-exo data. © The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) Is Selectively Toxic to Primary Dopaminergic Neurons In Vitro

Science.gov (United States)

Griggs, Amy M.; Agim, Zeynep S.; Mishra, Vartika R.; Tambe, Mitali A.; Director-Myska, Alison E.; Turteltaub, Kenneth W.; McCabe, George P.; Rochet, Jean-Christophe; Cannon, Jason R.

2014-01-01

Parkinson's disease (PD) is the second most common neurodegenerative disease. Much data has linked the etiology of PD to a variety of environmental factors. The majority of cases are thought to arise from a combination of genetic susceptibility and environmental factors. Chronic exposures to dietary factors, including meat, have been identified as potential risk factors. Although heterocyclic amines that are produced during high-temperature meat cooking are known to be carcinogenic, their effect on the nervous system has yet to be studied in depth. In this study, we investigated neurotoxic effects of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), a highly abundant heterocyclic amine in cooked meat, in vitro. We tested toxicity of PhIP and the two major phase I metabolites, N-OH-PhIP and 4′-OH-PhIP, using primary mesencephalic cultures from rat embryos. This culture system contains both dopaminergic and nondopaminergic neurons, which allows specificity of neurotoxicity to be readily examined. We find that exposure to PhIP or N-OH-PhIP is selectively toxic to dopaminergic neurons in primary cultures, resulting in a decreased percentage of dopaminergic neurons. Neurite length is decreased in surviving dopaminergic neurons. Exposure to 4′-OH-PhIP did not produce significant neurotoxicity. PhIP treatment also increased formation of oxidative damage markers, 4-hydroxy-2-nonenal (HNE) and 3-nitrotyrosine in dopaminergic neurons. Pretreatment with N-acetylcysteine was protective. Finally, treatment with blueberry extract, a dietary factor with known antioxidant and other protective mechanisms, prevented PhIP-induced toxicity. Collectively, our study suggests, for the first time, that PhIP is selectively toxic to dopaminergic neurons likely through inducing oxidative stress. PMID:24718704

Real-time resource availability signaling in IP multimedia subsystem networks

NARCIS (Netherlands)

Ozcelebi, T.; Radovanovic, I.; Sengupta, D.

2008-01-01

IP Multimedia Subsystem (IMS) allows the use of unlicensed, non-dedicated and nondeterministic access networks for delivering IP multimedia services. Providing end-to-end Quality-of-Service (QoS) for resource demanding real-time services (e.g. real-time multimedia) over such networks is a

PRODUCTION WITH 3D PRINTERS IN TEXTILES [REVIEW

Directory of Open Access Journals (Sweden)

KESKIN Reyhan

2015-05-01

Full Text Available 3D printers are gaining more attention, finding different applications and 3D printing is being regarded as a ‘revolution’ of the 2010s for production. 3D printing is a production method that produces 3-dimensional objects by combining very thin layers over and over to form the object using 3D scanners or via softwares either private or open source. 3D printed materials find application in a large range of fields including aerospace, automotive, medicine and material science. There are several 3D printing methods such as fused deposition modeling (FDM, stereolithographic apparatus (SLA, selective laser sintering (SLS, inkjet 3D printing and laminated object manufacturing (LOM. 3D printing process involves three steps: production of the 3D model file, conversion of the 3D model file into G-code and printing the object. 3D printing finds a large variety of applications in many fields; however, textile applications of 3D printing remain rare. There are several textile-like 3D printed products mostly for use in fashion design, for research purposes, for technical textile applications and for substituting traditional textiles suchas weft-knitted structures and lace patterns. 3D printed textile-like structures are not strong enough for textile applications as they tend to break easily and although they have the drape of a textile material, they still lack the flexibility of textiles. 3D printing technology has to gain improvement to produce materials that will be an equivalent for textile materials, and has to be a faster method to compete with traditional textile production methods.

Implementasi Server VoIP Berbasis SIP Pada LAN Nirkabel

Directory of Open Access Journals (Sweden)

Mohammad Shoffa Al Arofat

2013-03-01

Full Text Available Voice over Internet Protocol (VoIP merupakan teknologi yang memungkinkan percakapan suara jarak jauh melalui protokol internet. Dalam telekomunikasi, diperlukan teknologi pensinyalan yang berguna untuk membangun, mengawasi, dan melepas hubungan antara dua titik. Salah satu teknologi pensinyalan yang banyak digunakan untuk VoIP adalah Session Initiation Protocol, dengan implementasinya yang berupa perangkat lunak Open SIP Server. Selain pensinyalan, ada beberapa parameter yang perlu diperhatikan dalam implementasi VoIP, yaitu Mean Opinion Score (MOS, network impairment, dan bandwidth. Pengujian dilakukan terhadap enam codec, yaitu G.722, PCMA, PCMU, Speex, GSM, dan BV16. Berdasarkan hasil analisis dapat diambil kesimpulan bahwa codec yang menggunakan bandwidth paling rendah adalah Speex (27,12 kbps; Rata-rata delay yang dihasilkan oleh sipdroid lebih baik daripada jitsi.

Examples of modelling IP in AEM data: synthetic and real data

DEFF Research Database (Denmark)

Viezzoli, Andrea; Kaminskiy, Vladislav; Fiandaca, Gianluca

There have been multiple evidences in the literature in the past several years of what has been referred to as IP effect in the Time Domain Airborne EM data (TDEM). This phenomenon is known to be responsible for incorrect inversion modelling of electrical resistivity, lower interpreted depth...... of investigation and lost information about chargeability of the subsurface as well as about other valuable parameters. Historically there have been many suggestions to account for the IP effect using the Cole-Cole model. In current paper we are showing the possibility to extract IP information from airborne TDEM...... with both high electrical conductivity and in resistive environments. Furthermore, modelling of IP effects allows corrected resistivity models. The Amakinskaya kimberlite pipe results highlight the relevance of chargeability for kimberlite exploration....

Involvement of NMDA receptors and L-arginine/nitric oxide/cyclic guanosine monophosphate pathway in the antidepressant-like effects of topiramate in mice forced swimming test.

Science.gov (United States)

Ostadhadi, Sattar; Khan, Muhammad Imran; Norouzi-Javidan, Abbas; Chamanara, Mohsen; Jazaeri, Farahnaz; Zolfaghari, Samira; Dehpour, Ahmad-Reza

2016-04-01

Topiramate (TPM) is an agent primarily used in the treatment of epilepsy. Using mice model of forced swimming test (FST) the current study was basically aimed to investigate the influence of TPM on depression by inhibiting NMDA receptor and nitric oxide-cGMP production. When TPM was administered in a dose of 20 and 30 mg/kg by i.p. route it reduced the immobility time during FST. However this effect of TPM (30 mg/kg, i.p.) in the FST was abolished when the mice were pretreated either with NMDA (75 mg/kg, i.p.), or l-arginine (750 mg/kg, i.p. NO precursor), or sildenafil (5mg/kg, i.p. Phosphodiesterase 5 inhibitor). The immobility time in the FST was reduced after administration of L-NAME (10mg/kg, i.p, a non-specific NOS inhibitor), 7-nitoinidazol (30 mg/kg, i.p. a nNOS inhibitor) or MK-801 (0.05 mg/kg, i.p, a NMDA receptor antagonist) in combination with a subeffective dose of TPM (10mg/kg, i.p.) as compared with single use of either drug. Co-administrated of lower doses of MK-801 (0.01 mg/kg) or L-NAME (1mg/kg) failed to effect immobility time. However, simultaneous administration of these two agents in the same doses with subeffective dose of TPM (10mg/kg, i.p.), reduced the immobility time during FST. None of these drugs were found to have a profound effect on the locomotor activity per se during the open field test. Taken together, our data demonstrates that TPM exhibit antidepressant-like effect which is accomplished either due to inhibition of NMDA receptors or NO-cGMP production. Copyright © 2016 Elsevier Inc. All rights reserved.

Relating genes to function: identifying enriched transcription factors using the ENCODE ChIP-Seq significance tool.

Science.gov (United States)

Auerbach, Raymond K; Chen, Bin; Butte, Atul J

2013-08-01

Biological analysis has shifted from identifying genes and transcripts to mapping these genes and transcripts to biological functions. The ENCODE Project has generated hundreds of ChIP-Seq experiments spanning multiple transcription factors and cell lines for public use, but tools for a biomedical scientist to analyze these data are either non-existent or tailored to narrow biological questions. We present the ENCODE ChIP-Seq Significance Tool, a flexible web application leveraging public ENCODE data to identify enriched transcription factors in a gene or transcript list for comparative analyses. The ENCODE ChIP-Seq Significance Tool is written in JavaScript on the client side and has been tested on Google Chrome, Apple Safari and Mozilla Firefox browsers. Server-side scripts are written in PHP and leverage R and a MySQL database. The tool is available at http://encodeqt.stanford.edu. abutte@stanford.edu Supplementary material is available at Bioinformatics online.

3-D computer graphics based on integral photography.

Science.gov (United States)

Naemura, T; Yoshida, T; Harashima, H

2001-02-12

Integral photography (IP), which is one of the ideal 3-D photographic technologies, can be regarded as a method of capturing and displaying light rays passing through a plane. The NHK Science and Technical Research Laboratories have developed a real-time IP system using an HDTV camera and an optical fiber array. In this paper, the authors propose a method of synthesizing arbitrary views from IP images captured by the HDTV camera. This is a kind of image-based rendering system, founded on the 4-D data space Representation of light rays. Experimental results show the potential to improve the quality of images rendered by computer graphics techniques.

FAKTOR-FAKTOR YANG MEMPENGARUHI KESULITAN BELAJAR IPS TERPADU KELAS VII DI SMP NEGERI 1 PLANTUNGAN KABUPATEN KENDAL

Directory of Open Access Journals (Sweden)

Lina Maftukhah,

2012-10-01

Full Text Available Kesulitan belajar dipengaruhi oleh berbagai macam faktor, baik faktor intern maupun faktor ekstern. Berdasarkan hasil observasi dari data nilai UAS IPS Terpadu sebagian besar siswa kelas VII SMP Negeri 1 Plantungan mendapat nilai rendah dan menyebabkan tidak lulus KKM. Hal ini dapat dijadikan indikasi bahwa siswa mengalami kesulitan belajar IPS Terpadu. Permasalahan yang dikaji dalam penelitian ini adalah apa saja faktor-faktor yang mempengaruhi kesulitan belajar mata pelajaran IPS Terpadu Siswa Kelas VII dan faktor apakah yang lebih dominan mempengaruhi kesulitan belajar mata pelajaran IPS Terpadu Siswa Kelas VII SMP Negeri 1 Plantungan Kabupaten Kendal Tahun Ajaran 2011/2012. Penelitian ini bertujuan untuk mengetahui faktor-faktor apa saja yang mempengaruhi kesulitan belajar mata pelajaran IPS Terpadu dan faktor apakah yang lebih dominan mempengaruhi kesulitan belajar mata pelajaran IPS Terpadu. Penelitian ini dilakukan di SMP N egeri 1 Plantungan Kabupaten Kendal. Populasi penelitian ini adalah siswa kelas VII sebanyak 131 siswa. Pengambilan sampel dilakukan secara proposional claster random sampling dan didapat sampel sebanyak 100 siswa. Variabel dalam penelitian ini adalah faktor-faktor yang mempengaruhi kesulitan belajar IPS Terpadu kelas VII SMP Negeri 1 Plantungan Kabupaten Kendal. Metode pengumpulan data yang digunakan adalah metode kuesioner dan dokumentasi. Sedangkan untuk analisis data yang digunakan adalah analisis faktor dan deskriptif persentase. Berdasarkan analisis faktor terdapat 5 komponen yang akan membentuk 5 faktor baru. Adapun tingkat kesulitan belajar siswa dari 5 faktor baru berdasarkan uji Deskripsi Persentase sebagai berikut : (a kemampuan siswa 61,55%, (b kemampuan guru 66,75%, (c sarana penunjang 77,00%, (d dukungan sekolah 72,67%, (e dukungan keluarga 62,00%. Dari kelima faktor yang ada, faktor kemampuan siswa merupakan pengaruh yang paling dominan dengan koefisien varian sebesar 61,55% dengan kategori menghambat

Influence of predators and parisitoids on bark beetle productivity

Science.gov (United States)

Jan Weslien

1991-01-01

In an earlier field experiment, natural enemies of the bark beetle, Ips typographus (L) were estimated to have reduced bark beetle productivity by more than 80 percent. To test this hypothesis, spruce logs (Picea abies) were placed in the forest in the spring, prior to commencement of flight by I. typographus....

VoIP interconnection ; between Internet, Cable, Mobile and Fixed Worlds

NARCIS (Netherlands)

Deventer, M.O. van; Keesmaat, I.

2005-01-01

Four worlds on their own that hardly interconnect; All use SIP, but differently - Internet world - Mobile world - Cable world - Fixed world - At most, only basic voice service will interoperate between those worlds In recent years, VoIP/multimedia services (VoIP: Voice over Internet Protocol) have

Protecting LHC IP1/IP5 Components Against Radiation Resulting from Colliding Beam Interactions

CERN Document Server

Mokhov, N V; Kerby, J S; Strait, J B

2003-01-01

Beam-induced energy deposition in the LHC high luminosity interaction region (IR) components due to both pp collisions and beam loss in the IR vicinity is a significant challenge for the design of the high luminosity insertions. It was shown in our previous studies that a set of absorbers would reduce both the peak power density and total heat load to tolerable levels. In this paper the results of further optimization and comprehensive MARS calculations are summarized for the LHC lattice, version 6.4, for the updated IP1 and IP5 layouts and a baseline pp-collision source term. Power density, power dissipation, particle fluxes and spectra, accumulated dose and residual dose rates are studied in the components of the inner triplets including their TAS absorbers, the TAN neutral beam absorbers, separation dipoles, and quadrupoles of the outer triplets and possible collimators there. Results are given for the nominal luminosity of 1034 cm-2 s-1. The current design is proved to provide the best safety margin under...

Analysis of ChIP-seq Data in R/Bioconductor.

Science.gov (United States)

de Santiago, Ines; Carroll, Thomas

2018-01-01

The development of novel high-throughput sequencing methods for ChIP (chromatin immunoprecipitation) has provided a very powerful tool to study gene regulation in multiple conditions at unprecedented resolution and scale. Proactive quality-control and appropriate data analysis techniques are of critical importance to extract the most meaningful results from the data. Over the last years, an array of R/Bioconductor tools has been developed allowing researchers to process and analyze ChIP-seq data. This chapter provides an overview of the methods available to analyze ChIP-seq data based primarily on software packages from the open-source Bioconductor project. Protocols described in this chapter cover basic steps including data alignment, peak calling, quality control and data visualization, as well as more complex methods such as the identification of differentially bound regions and functional analyses to annotate regulatory regions. The steps in the data analysis process were demonstrated on publicly available data sets and will serve as a demonstration of the computational procedures routinely used for the analysis of ChIP-seq data in R/Bioconductor, from which readers can construct their own analysis pipelines.

Optimal use of tandem biotin and V5 tags in ChIP assays

Directory of Open Access Journals (Sweden)

Krpic Sanja

2009-02-01

Full Text Available Abstract Background Chromatin immunoprecipitation (ChIP assays coupled to genome arrays (Chip-on-chip or massive parallel sequencing (ChIP-seq lead to the genome wide identification of binding sites of chromatin associated proteins. However, the highly variable quality of antibodies and the availability of epitopes in crosslinked chromatin can compromise genomic ChIP outcomes. Epitope tags have often been used as more reliable alternatives. In addition, we have employed protein in vivo biotinylation tagging as a very high affinity alternative to antibodies. In this paper we describe the optimization of biotinylation tagging for ChIP and its coupling to a known epitope tag in providing a reliable and efficient alternative to antibodies. Results Using the biotin tagged erythroid transcription factor GATA-1 as example, we describe several optimization steps for the application of the high affinity biotin streptavidin system in ChIP. We find that the omission of SDS during sonication, the use of fish skin gelatin as blocking agent and choice of streptavidin beads can lead to significantly improved ChIP enrichments and lower background compared to antibodies. We also show that the V5 epitope tag performs equally well under the conditions worked out for streptavidin ChIP and that it may suffer less from the effects of formaldehyde crosslinking. Conclusion The combined use of the very high affinity biotin tag with the less sensitive to crosslinking V5 tag provides for a flexible ChIP platform with potential implications in ChIP sequencing outcomes.

Optimal use of tandem biotin and V5 tags in ChIP assays

Science.gov (United States)

Kolodziej, Katarzyna E; Pourfarzad, Farzin; de Boer, Ernie; Krpic, Sanja; Grosveld, Frank; Strouboulis, John

2009-01-01

Background Chromatin immunoprecipitation (ChIP) assays coupled to genome arrays (Chip-on-chip) or massive parallel sequencing (ChIP-seq) lead to the genome wide identification of binding sites of chromatin associated proteins. However, the highly variable quality of antibodies and the availability of epitopes in crosslinked chromatin can compromise genomic ChIP outcomes. Epitope tags have often been used as more reliable alternatives. In addition, we have employed protein in vivo biotinylation tagging as a very high affinity alternative to antibodies. In this paper we describe the optimization of biotinylation tagging for ChIP and its coupling to a known epitope tag in providing a reliable and efficient alternative to antibodies. Results Using the biotin tagged erythroid transcription factor GATA-1 as example, we describe several optimization steps for the application of the high affinity biotin streptavidin system in ChIP. We find that the omission of SDS during sonication, the use of fish skin gelatin as blocking agent and choice of streptavidin beads can lead to significantly improved ChIP enrichments and lower background compared to antibodies. We also show that the V5 epitope tag performs equally well under the conditions worked out for streptavidin ChIP and that it may suffer less from the effects of formaldehyde crosslinking. Conclusion The combined use of the very high affinity biotin tag with the less sensitive to crosslinking V5 tag provides for a flexible ChIP platform with potential implications in ChIP sequencing outcomes. PMID:19196479

Emancipating Intellectual Property from Proprietarianism: Drahos, Foucault, and a Quasi-Genealogy of IP

Directory of Open Access Journals (Sweden)

Wendyl Luna

2018-01-01

Full Text Available This paper argues that Peter Drahos undertakes a partial Foucauldian genealogy by emancipating intellectual property (IP from proprietarianism. He demonstrates the dominance of proprietarianism in IP by drawing sample practices from trademark, copyright, and patent laws, and then seeks to displace the proprietarian dominance with instrumentalism, which reconstitutes IP as a “liberty-intruding privilege.” Ironically, despite doing a genealogy, Drahos does not eradicate sovereignty altogether as Michel Foucault insists, but instead determines IP as a “sovereignty mechanism” that has a “sovereignty effect.” After explaining what Foucauldian genealogy is, the paper will explain how Drahos undertakes a genealogy of IP, while highlighting the limitations of Drahos’ analysis from a Foucauldian perspective.

Near Fault Observatories: multidisciplinary research infrastructures, high resolution data and scientific products available through dedicated services implemented within the EPOS-IP project

Science.gov (United States)

Festa, Gaetano; Chiaraluce, Lauro; Ergintav, Semih; Bernard, Pascal; Clinton, John; Marmureanu, Alexandru; Tataru, Dragos; Vogfjord, Kristin

2017-04-01

Near Fault Observatories (NFOs) are innovative research infrastructures based on dense, state of the art networks of multi-parametric sensors that continuously monitor the underlying Earth instability processes over a broad time interval. They aim at understanding the physical/chemical processes responsible for earthquakes and faulting and tracking their evolution over time by enabling advancements in ground shaking prediction. EPOS-IP is aimed at contributing in creating and harmonizing data and products distributors from seven NFOs, operating on different tectonic regimes and different areas of Europe. They include plate boundary systems at South Iceland Seismic Zone, the Marmara Sea and the Corinth rift. In mountain settings, NFOs monitor the Alto Tiberina and Irpinia faults in the Apennine mountain range, the Valais region in the Alps, and the Vrancea fault in the Carpathian Mountains. They monitor diverse faulting mechanisms (strike-slip, normal and thrust), high to low angle faults, shallow and deep faults, as well as regions with fast and slow strain rate accumulation. The focus of the observatories varies, ranging from small- to large-scale seismicity and includes the role of different parameters such as fluid playing in fault initiation, the internal structure of fault systems, site effects and derived processes such as earthquake generated landslides and tsunamis. In response to their specific objectives, the NFOs operate a diverse set of monitoring instrumentation using seismic, deformation, strain, geochemical and electromagnetic equipment. Since NFO methodological approach is based on extremely dense networks and less common instruments deserving multi-parameter data description, a main goal of this group is to build inclusive and harmonised services supporting the installation over the next decade of tens of near-fault observatories monitoring active faults in different tectonic environments in Europe. The NFO Thematic Core Service (TCS) relies on

(S)-(+)-Ipsdienol: Interspecific Inhibition of Ips latidens (LeConte) by Ips pini (Say) (Coleoptera: Scolytidae)

Science.gov (United States)

Daniel R. Miller; John H. Borden

1992-01-01

In south-central British Columbia, the attraction of Ips latidens (LeConte) to its pheromone, ipsenol, was inhibited by (S)-(+)-ipsdienol, a pheromone for I. pini (Say). (R)-(-)-Ipsdienol had no effect on I. latidens. (S)-(+)-lpsdienol probably plays a role in interspecific communication between the two species...

Analisis Data Digital Evidence pada Layanan Voice Over Internet Protocol (VoIP

Directory of Open Access Journals (Sweden)

Muhamad Arsad Adam

2016-11-01

Full Text Available Teknologi  VoIP  (Voice  Over  Internet  Protocol merupakan  teknologi  yang  mampu  melewatkan  panggilan  suara, video  dan  data  dalam  jaringan  IP.  Voice  over  Internet  Protocol (VoIP  dalam  teknologi  komunikasi  cukup  signifikan  sehingga tidak  terlepas  dari  kejahatan  cybercrime,  Teknologi  VoIP  dapat disalahgunakan  untuk  melakukan  tindakan  kejahatan  jarak  jauh sehingga  diperlukan  langkah-langkah  investigasi  jika  terjadi masalah.  Menemukan  artefact  pada  Infrastruktur  VoIP merupakan tantangan tersendiri. WireSharks salah satu tool yang digunakan  dalam  investigasi  ini.  Metode  yang  digunakan  adalah DFIF  yang  terdiri  tahapan  adalah  Collection,  Examination, Analysis, dan Report and Documentation. Investigasi pada layanan VoIP  dapat  berhasil  dilakukan  dengan  menemukan  data  digital evidence  di  layer  5.  Tujuan  Penelitian  ini  yaitu  Mengetahui Karakteristik Data Digital berupa suara pada layanan Voice Over IP  dan  Menganalisis  Data  Digital  berupa  suara  pada  layanan Voice Over IP. Hasil dari penelitian ini barang bukti digital yang berupa  percakapan  yang  dapat  dipertanggungjawabkan  dalam pengadilan..Kata kunci— Data, Evidence, Forensik,Network, VoIP

Study of interstellar helium from photometric observations at 58.4 nm of the interplanetary environment from Prognoz 6 satellite

International Nuclear Information System (INIS)

Dalaudier, Francis.

1981-06-01

This thesis is devoted to an ''interplanetary helium'' experiment, the aim of the work being to acquire a greater understanding of the local interstellar environment and its interaction with the solar system. Measurements made from the Prognoz 6 satellite on ultraviolet fluxes from hydrogen (121.6 nm) and neutral and ionized helium (58.4 nm and 30.4 nm respectively) were used to construct a computer model. Most of the work performed deals with comparing and interpreting the results obtained [fr

Impact of time-domain IP pulse length on measured data and inverted models

DEFF Research Database (Denmark)

Olsson, P. I.; Fiandaca, G.; Dahlin, T.

2015-01-01

The duration of time domain (TD) induced polarization (IP) current injections has significant impact on the acquired IP data as well as on the inversion models, if the standard evaluation procedure is followed. However, it is still possible to retrieve similar inversion models if the waveform...... of the injected current and the IP response waveform are included in the inversion. The on-time also generally affects the signal-tonoise ratio (SNR) where an increased on-time gives higher SNR for the IP data....

Análise qualitativa do relato de mães com sintomatologia depressiva participantes do projeto Ipê

OpenAIRE

Marina Valente Guimarães Cecchini

2010-01-01

Este estudo faz parte do projeto temático Ipê; uma pesquisa longitudinal sobre depressão pós-parto (DPP), suas possíveis causas e conseqüências para a interação mãebebê e para o desenvolvimento infantil. As participantes do Ipê são atendidas pelo sistema único de saúde (SUS) da região do Butantã, em São Paulo, e foram entrevistadas em diversos momentos, inclusive no terceiro trimestre de gestação. As díades mãe-bebê foram avaliadas dois dias após o parto, no terceiro e no quarto mês de idade ...

Considerations on VoIP Throughput in 802.11 Networks

Directory of Open Access Journals (Sweden)

POTORAC, A. D.

2009-10-01

Full Text Available Voice data packets have to arrive at the destination in time, with a defined cadence and with low and constant delay in order to allow the real time voice reconstruction. From this point of view, transmitting voice over IP networks is the most sensitive category of applications, especially when wireless medium is involved. The paper discusses the possibilities of transmitting the maximum number of simultaneous voice streams over 802.11 wireless networks considering the main factors which impact with VoIP throughput, in a basic scenario. Starting from a proposed communication model, the number of simultaneous possible VoIP sessions is calculated, taking into consideration the contribution of the protocol overheads, the security overheads, the PHY level timings and the CODEC proprieties. Numerical results are generated and compared.

Agricultural R&D, technology and productivity.

Science.gov (United States)

Piesse, J; Thirtle, C

2010-09-27

The relationships between basic and applied agricultural R&D, developed and developing country R&D and between R&D, extension, technology and productivity growth are outlined. The declining growth rates of public R&D expenditures are related to output growth and crop yields, where growth rates have also fallen, especially in the developed countries. However, growth in output value per hectare has not declined in the developing countries and labour productivity growth has increased except in the EU. Total factor productivity has generally increased, however it is measured. The public sector share of R&D expenditures has fallen and there has been rapid concentration in the private sector, where six multinationals now dominate. These companies are accumulating intellectual property to an extent that the public and international institutions are disadvantaged. This represents a threat to the global commons in agricultural technology on which the green revolution has depended. Estimates of the increased R&D expenditures needed to feed 9 billion people by 2050 and how these should be targeted, especially by the Consultative Group on International Agricultural Research (CGIAR), show that the amounts are feasible and that targeting sub-Saharan Africa (SSA) and South Asia can best increase output growth and reduce poverty. Lack of income growth in SSA is seen as the most insoluble problem.

Threshold-based generic scheme for encrypted and tunneled Voice Flows Detection over IP Networks

Directory of Open Access Journals (Sweden)

M. Mazhar U. Rathore

2015-07-01

Full Text Available VoIP usage is rapidly growing due to its cost effectiveness, dramatic functionality over the traditional telephone network and its compatibility with public switched telephone network (PSTN. In some countries, like Pakistan, the commercial usage of VoIP is prohibited. Internet service providers (ISPs and telecommunication authorities are interested in detecting VoIP calls to either block or prioritize them. So detection of VoIP calls is important for both types of authorities. Signature-based, port-based, and pattern-based VoIP detection techniques are inefficient due to complex and confidential security and tunneling mechanisms used by VoIP. In this paper, we propose a generic, robust, efficient, and practically implementable statistical analysis-based solution to identify encrypted, non-encrypted, or tunneled VoIP media (voice flows using threshold values of flow statistical parameters. We have made a comparison with existing techniques and evaluated our system with respect to accuracy and efficiency. Our system has 97.54% direct rate and .00015% false positive rate.

Modeling the downward transport of 210Pb in Peatlands: Initial Penetration‐Constant Rate of Supply (IP-CRS) model

International Nuclear Information System (INIS)

Olid, Carolina; Diego, David; Garcia-Orellana, Jordi; Cortizas, Antonio Martínez; Klaminder, Jonatan

2016-01-01

The vertical distribution of 210 Pb is commonly used to date peat deposits accumulated over the last 100–150 years. However, several studies have questioned this method because of an apparent post-depositional mobility of 210 Pb within some peat profiles. In this study, we introduce the Initial Penetration–Constant Rate of Supply (IP-CRS) model for calculating ages derived from 210 Pb profiles that are altered by an initial migration of the radionuclide. This new, two-phased, model describes the distribution of atmospheric-derived 210 Pb ( 210 Pb xs ) in peat taking into account both incorporation of 210 Pb into the accumulating peat matrix as well as an initial flushing of 210 Pb through the uppermost peat layers. The validity of the IP-CRS model is tested in four anomalous 210 Pb peat records that showed some deviations from the typical exponential decay profile not explained by variations in peat accumulation rates. Unlike the most commonly used 210 Pb-dating model (Constant Rate of Supply (CRS)), the IP-CRS model estimates peat accumulation rates consistent with typical growth rates for peatlands from the same areas. Confidence in the IP-CRS chronology is also provided by the good agreement with independent chronological markers (i.e. 241 Am and 137 Cs). Our results showed that the IP-CRS can provide chronologies from peat records where 210 Pb mobility is evident, being a valuable tool for studies reconstructing past environmental changes using peat archives during the Anthropocene. - Highlights: • Accurate age dating of peat and sediment cores is critical for evaluating change. • A new 210 Pb dating model that includes vertical transport of 210 Pb was developed. • The IP-CRS model provided consistent peat accumulation rates. • The IP-CRS ages were consistent with independent chronological markers. • The IP-CRS model derives peat ages where downward 210 Pb transport is evidenced.

Deleting the accessory subunit KChIP2 results in loss of I(to,f) and increased I(K,slow) that maintains normal action potential configuration

DEFF Research Database (Denmark)

Thomsen, Morten B; Sosunov, Eugene A; Anyukhovsky, Evgeny P

2008-01-01

BACKGROUND: Four voltage-gated potassium currents, I(to,f) (K(V)4.2), I(to,s) (K(V)1.4), I(K,slow) (K(V)1.5+K(V)2.1), and I(SS) (TASK1), govern murine ventricular repolarization. Although the accessory subunit KChIP2 influences I(to,f) expression, in preliminary experiments we found that action...... potential duration (APD) is maintained in KChIP2 knockout mice. OBJECTIVE: We tested the role of KChIP2 in regulating APD and studied the underlying ionic currents. METHODS: We used microelectrode techniques, whole-cell patch clamp studies, and real-time polymerase chain reaction amplification...... to characterize ventricular repolarization and its determinants in wild-type and KChIP2(-/-) mice. RESULTS: Despite comparable baseline action potentials, APD was more markedly prolonged by 4-aminopyridine (4-AP) in KChIP2(-/-) preparations. Peak K(+) current densities were similar in wild-type and KChIP2...

PENGGUNAAN METODE SIMULASI DALAM PEMBELAJARAN KETERAMPILAN LITERASI INFORMASI IPS BAGI MAHASISWA PGSD

Directory of Open Access Journals (Sweden)

Ana Nurhasanah

2016-06-01

Full Text Available Abstrak. Mata pelajaran IPS di Sekolah Dasar dikembangkan sebagai mata pelajaran terintegrasi atau integrative social studies, bukan sebagai pendidikan disiplin ilmu. Tantangan yang dihadapi peserta didik saat ini adalah banyak dan beragamnya masalah-masalah sosial yang harus dihadapi dalam kehidupan sehari-hari, oleh sebab itu pembelajaran IPS bertujuan untuk  mengembangkan keterampilan sosial. Namun, mengingat perkembangan siswa SD yang masih dalam tingkat berpikir kongkrit maka disarankan pembelajaran IPS SD menggunakan contoh-contoh masalah sosial yang kongkrit dan yang  mungkin melibatkan pengalaman-pengalaman siswa SD secara langsung. Namun dalam kenyataannya berdasarkan wawancara pada guru-guru SD di kota Serang masih banyak ditemukan kesulitan dalam mengajarkan IPS. Hal ini menunjukan bahwa kemampuan guru-guru di SD belum sesuai dengan tuntutan tujuan pembelajaran IPS. Oleh sebab itu penting kiranya mahasiswa PGSD semester V sebagai calon tenaga pendidik dibekali pengalaman dengan metode simulasi guna mengembangkan literasi informasi pada pembelajaran IPS yang menunjang pada pengembangan karir profesionalnya nanti. Kata kunci: metode simulasi, literasi informasi IPS, dan mahasiswa  Abstract. Social studies in elementary school subjects developed as an integrated or integrative social studies, not as educational disciplines. The challenges facing students today are many and varied social problems that must be faced in everyday life, so learning IPS aims to develop social skills. However, considering the development of elementary school students who are still in the level of concrete thinking it is advisable elementary social studies learning using examples of concrete social problems and that may involve experiences elementary students directly. But in reality based on the interviews of the teachers in the city of Serang there are still many difficulties in teaching social studies. This shows that the ability of teachers in primary

Effective Domain Partitioning for Multi-Clock Domain IP Core Wrapper Design under Power Constraints

Science.gov (United States)

Yu, Thomas Edison; Yoneda, Tomokazu; Zhao, Danella; Fujiwara, Hideo

The rapid advancement of VLSI technology has made it possible for chip designers and manufacturers to embed the components of a whole system onto a single chip, called System-on-Chip or SoC. SoCs make use of pre-designed modules, called IP-cores, which provide faster design time and quicker time-to-market. Furthermore, SoCs that operate at multiple clock domains and very low power requirements are being utilized in the latest communications, networking and signal processing devices. As a result, the testing of SoCs and multi-clock domain embedded cores under power constraints has been rapidly gaining importance. In this research, a novel method for designing power-aware test wrappers for embedded cores with multiple clock domains is presented. By effectively partitioning the various clock domains, we are able to increase the solution space of possible test schedules for the core. Since previous methods were limited to concurrently testing all the clock domains, we effectively remove this limitation by making use of bandwidth conversion, multiple shift frequencies and properly gating the clock signals to control the shift activity of various core logic elements. The combination of the above techniques gains us greater flexibility when determining an optimal test schedule under very tight power constraints. Furthermore, since it is computationally intensive to search the entire expanded solution space for the possible test schedules, we propose a heuristic 3-D bin packing algorithm to determine the optimal wrapper architecture and test schedule while minimizing the test time under power and bandwidth constraints.

Myricetin stimulates the absorption of the pro-carcinogen PhIP

NARCIS (Netherlands)

Schutte, M.E.; Sandt, J.J.M. van de; Alink, G.M.; Groten, J.P.; Rietjens, I.M.C.M.

2006-01-01

The effect of the flavonoid myricetin on the transport of the pro-carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) through differentiated Caco-2 monolayers, a model for the intestinal epithelium, is described. Myricetin causes an increase of the transport of PhIP from the apical to

Universal Space IP Transparent Proxy, Phase II

Data.gov (United States)

National Aeronautics and Space Administration — Communications applications are strategically moving toward Internet Protocol-based architectures and technologies. Despite IP's huge potential, (e.g. cost...

Comparison of 3D two-point Dixon and standard 2D dual-echo breath-hold sequences for detection and quantification of fat content in renal angiomyolipoma

International Nuclear Information System (INIS)

Rosenkrantz, Andrew B.; Raj, Sean; Babb, James S.; Chandarana, Hersh

2012-01-01

Purpose: To assess the utility of a 3D two-point Dixon sequence with water–fat decomposition for quantification of fat content of renal angiomyolipoma (AML). Methods: 84 patients underwent renal MRI including 2D in-and-opposed-phase (IP and OP) sequence and 3D two-point Dixon sequence that generates four image sets [IP, OP, water-only (WO), and fat-only (FO)] within one breath-hold. Two radiologists reviewed 2D and 3D images during separate sessions to identify fat-containing renal masses measuring at least 1 cm. For identified lesions subsequently confirmed to represent AML, ROIs were placed at matching locations on 2D and 3D images and used to calculate 2D and 3D SI index [(SI IP − SI OP )/SI IP ] and 3D fat fraction (FF) [SI FO /(SI FO + SI WO )]. 2D and 3D SI index were compared with 3D FF using Pearson correlation coefficients. Results: 41 AMLs were identified in 6 patients. While all were identified using the 3D sequence, 39 were identified using the 2D sequence, with the remaining 2 AMLs retrospectively visible on 2D images but measuring under 1 cm. Among 32 AMLs with a 3D FF of over 50%, both 2D and 3D SI index showed a statistically significant inverse correlation with 3D FF (2D SI index : r = −0.63, p = 0.0010; 3D SI index : r = −0.97, p index , is not limited by ambiguity of water or fat dominance. This may assist clinical management of AML given evidence that fat content predicts embolization response.

47 CFR 64.606 - VRS and IP Relay provider and TRS program certification.

Science.gov (United States)

2010-10-01

... 47 Telecommunication 3 2010-10-01 2010-10-01 false VRS and IP Relay provider and TRS program... Services and Related Customer Premises Equipment for Persons With Disabilities § 64.606 VRS and IP Relay... including notification in the Federal Register. (2) VRS and IP Relay provider. Any entity desiring to...

Novel characteristics of CtIP at damage-induced foci following the initiation of DNA end resection

International Nuclear Information System (INIS)

Fujisawa, Hiroshi; Fujimori, Akira; Okayasu, Ryuichi; Uesaka, Mitsuru; Yajima, Hirohiko

2015-01-01

Highlights: • CtIP becomes hyperphosphorylated and forms foci following cell irradiation. • CtIP accumulates in foci subsequent to the peak of hyperphosphorylation. • CtIP is maintained in a hypophosphorylated state at later times. • CtIP is continuously recruited to DNA double strand breaks downstream of resection. • CtIP presumably have a distinct role following the initiation of resection. - Abstract: Homologous recombination (HR) is a major repair pathway for DNA double strand breaks (DSBs), and end resection, which generates a 3′-single strand DNA tail at the DSB, is an early step in the process. Resection is initiated by the Mre11 nuclease together with CtIP. Here, we describe novel characteristics of CtIP at DSBs. At early times following exposure of human cells to ionizing radiation, CtIP localized to the DSB, became hyperphosphorylated and formed foci in an ATM-dependent manner. At later times, when the initiation of resection had occurred, CtIP foci persist but CtIP is maintained in a hypophosphorylated state, which is dependent on ATM and ATR. Exposure to cycloheximide revealed that CtIP turns over at DSB sites downstream of resection. Our findings provide strong evidence that CtIP is continuously recruited to DSBs downstream of both the initiation and extension step of resection, strongly suggesting that CtIP has functions in addition to promoting the initiation of resection during HR

PENGEMBANGAN PERANGKAT PEMBELAJARAN IPS DENGAN PENDEKATAN INQUIRY

Directory of Open Access Journals (Sweden)

Lisna Handayani

2015-08-01

Full Text Available Tujuan  penelitian adalah menghasilkan perangkat pembelajaran IPS dengan Pendekatan Inquiry. Penelitian pengembangan ini menggunakan langkah-langkah Borg and Gall yang terdiri dari tiga tahapan utama yaitu pendahuluan, pengembangan dan validasi. Data yang diperoleh adalah hasil belajar, aktivitas diskusi dan respon peserta didik. Data dianalisis menggunakan analisis deskriptif dan uji t. Penggunaan pendekatan inquiry sebagai salah satau strategi pembelajaran IPS dapat dilakukan dengan mempersiapkan terlebih dahulu perangkat pembelajarannya. Hasil pengembangan divalidasi oleh pakar, diujicobakan pada kelas terbatas dan selanjutnya dilakukan ujicoba pada kelas eksperimen yang dibandingkan hasilnya dengan kelas kontrol. Perangkat pembelajaran tergolong efektif untuk meningkatkan hasil belajar peserta didik di kelas VII SMP Negeri 2 Jepara, terbukti dari adanya peningkatan yang nyata terbukti dari hasil uji paired sampel t-test dengan nilai signifikansi 0,000 <0,05, dan terjadi peningkatan yang tinggi (gain > 0,7, serta hasil belajar yang dicapai berbeda secara signifikan dengan kelompok kontrol. Di samping hasil belajar, pembelajaran yang dilakukan juga berdampak pada proses belajar yang membawa tingginya aktivitas peserta didik dalam memberikan gagasan, kerjasama, inisiatif, keaktifan dan kedisiplinan. The purpose of this research is creating Social Lesson Material with Inquiry Approach.This developing of the research is used of  the steps of Borg and Gall. They are Introducing, developing and evaluating. Learning materials are developed and validity by expert. Datas are gooten by study result, discussion activity and students, respone. Analizing datas are used descriptive analize and t- try out. The use of inquiry approach as one of learning strategy on Social Lesson Material can be done by preparing those. The result of  developing are being validity by expert,  try out on limited group and experiment group ad compare with control group

A study on opening displacement of lid and decrease in shielding thickness of a type IP-2 transport package in drop events

International Nuclear Information System (INIS)

Kim, Dong Hak; Seo, Ki Seog; Kim, Jae Yong; Lee, Ju Chan; Yoon, Jeong Hyoun; Lee, Kyung Ho; Kim, Sung Hwan; Lee, Heung Young

2005-01-01

Radioactive waste generated from nuclear power plants shall be transported in accordance with designated regulations, which is to protect radiation workers and the public against potential radiation exposure caused by the transportations. Each transport package of radioactive waste is to be designed to have enough safety to fulfill with the regulations and technical standards in domestic and foreign regulations. In accordance with IAEA safety standard series TS-R-1 which is widely accepted by most of its member states, industrial package can be divided into IP-1, IP-2 and IP-3 along with other Type A and Type B packages, a conventional clarification. IP-2 package shall be designed to meet the designated requirements in addition to those for type IP-1 package. IP-2 package is subject to the free drop and stacking tests under normal conditions of transport as regulated in the regulation. In this paper, opening displacement of lid and body and decrease in shielding thickness of an IP-2 package are analytically evaluated, which is proposed for on-site transportation in domestic nuclear power plants. The results of the analysis is compared with design requirements of the package that loss or dispersal of the radioactive contents should be prevented and total loss of shielding effect from free drop shall be less than 20%

Measurement of D0, D+, D+s and D*+ production in fixed target 920 GeV proton-nucleus collisions

International Nuclear Information System (INIS)

Abt, I.

2007-08-01

The inclusive production cross sections of the charmed mesons D 0 , D + , D + s and D *+ have been measured in interactions of 920 GeV protons on C, Ti, and W targets with the HERA-B detector at the HERA storage ring. Differential cross sections as a function of transverse momentum and Feynman's x variable are given for the central rapidity region and for transverse momenta up to p T =3.5 GeV/c. The atomic mass number dependence and the leading to non-leading particle production asymmetries are presented as well. (orig.)

Architecture and Design of IP Broadcasting System Using Passive Optical Network

Science.gov (United States)

Ikeda, Hiroki; Sugawa, Jun; Ashi, Yoshihiro; Sakamoto, Kenichi

We propose an IP broadcasting system architecture using passive optical networks (PON) utilizing the optical broadcast links of a PON with a downstream bandwidth allocation algorithm to provide a multi-channel IP broadcasting service to home subscribers on single broadband IP network infrastructures. We introduce the design and adaptation of the optical broadcast links to effectively broadcast video contents to home subscribers. We present a performance analysis that includes the downstream bandwidth utilization efficiency of the broadcast link and the bandwidth control of the IP broadcasting and Internet data. Our analysis and simulation results show that the proposed system can provide 100 HDTV channels to every user over fiber lines. We also propose an IPTV channel selection mechanism in an ONT by selecting a broadcast stream. We developed and evaluated a prototype that can achieve a 15-msec IPTV channel selection speed.

VoIP for Telerehabilitation: A Pilot Usability Study for HIPAA Compliance

Directory of Open Access Journals (Sweden)

Valerie R. Watzlaf

2012-06-01

Full Text Available Consumer-based, free Voice and video over the Internet Protocol (VoIP software systems such as Skype and others are used by health care providers to deliver telerehabilitation and other health-related services to clients. Privacy and security applications as well as HIPAA compliance within these protocols have been questioned by practitioners, health information managers, and other healthcare entities. This pilot usability study examined whether four respondents who used the top three, free consumer-based, VoIP software systems perceived these VoIP technologies to be private, secure, and HIPAA compliant;  most did not.  While the pilot study limitations include the number of respondents and systems assessed, the protocol can be applied to future research and replicated for instructional purposes.  Recommendations are provided for VoIP companies, providers, and users. 

Testing knowledge of whole English collocations available for use in written production

DEFF Research Database (Denmark)

Revier, Robert Lee

2014-01-01

Testing knowledge of whole English collocations available for use in written production: Developing tests for use with intermediate and advanced Danish learners (dansk resume nedenfor) The present foreign language acquisition research derives its impetus from four assumptions regarding knowledge...... of English collocations. These are: (a) collocation knowledge can be conceptualized as an independent knowledge construct, (b) collocations are lexical items in their own right, (c) testing of collocation knowledge should also target knowledge of whole collocations, and (d) the learning burden of a whole...... the development of Danish EFL learners’ productive knowledge of whole English collocations. Five empirical studies were designed to generate information that would shed light on the reliability and validity of the CONTRIX as a measure of collocation knowledge available for use in written production. Study 1...

Genome Therapy of Myotonic Dystrophy Type 1 iPS Cells for Development of Autologous Stem Cell Therapy.

Science.gov (United States)

Gao, Yuanzheng; Guo, Xiuming; Santostefano, Katherine; Wang, Yanlin; Reid, Tammy; Zeng, Desmond; Terada, Naohiro; Ashizawa, Tetsuo; Xia, Guangbin

2016-08-01

Myotonic dystrophy type 1 (DM1) is caused by expanded Cytosine-Thymine-Guanine (CTG) repeats in the 3'-untranslated region (3' UTR) of the Dystrophia myotonica protein kinase (DMPK) gene, for which there is no effective therapy. The objective of this study is to develop genome therapy in human DM1 induced pluripotent stem (iPS) cells to eliminate mutant transcripts and reverse the phenotypes for developing autologous stem cell therapy. The general approach involves targeted insertion of polyA signals (PASs) upstream of DMPK CTG repeats, which will lead to premature termination of transcription and elimination of toxic mutant transcripts. Insertion of PASs was mediated by homologous recombination triggered by site-specific transcription activator-like effector nuclease (TALEN)-induced double-strand break. We found genome-treated DM1 iPS cells continue to maintain pluripotency. The insertion of PASs led to elimination of mutant transcripts and complete disappearance of nuclear RNA foci and reversal of aberrant splicing in linear-differentiated neural stem cells, cardiomyocytes, and teratoma tissues. In conclusion, genome therapy by insertion of PASs upstream of the expanded DMPK CTG repeats prevented the production of toxic mutant transcripts and reversal of phenotypes in DM1 iPS cells and their progeny. These genetically-treated iPS cells will have broad clinical application in developing autologous stem cell therapy for DM1.

The antidepressant-like effect of 7-fluoro-1,3-diphenylisoquinoline-1-amine in the mouse forced swimming test is mediated by serotonergic and dopaminergic systems.

Science.gov (United States)

Pesarico, Ana Paula; Sampaio, Tuane Bazanella; Stangherlin, Eluza Curte; Mantovani, Anderson C; Zeni, Gilson; Nogueira, Cristina Wayne

2014-10-03

The aim of the present study was to investigate the role of monoaminergic system in the antidepressant-like action of 7-fluoro-1,3-diphenylisoquinoline-1-amine (FDPI), a derivative of isoquinoline class, in Swiss mice. The antidepressant-like effect of FDPI was characterized in the modified forced swimming test (FST) and the possible mechanism of action was investigated by using serotonergic, dopaminergic and noradrenergic antagonists. Monoamine oxidase (MAO) activity and [(3)H]serotonin (5-HT) uptake were determined in prefrontal cortices of mice. The results showed that FDPI (1, 10 and 20mg/kg, i.g.) reduced the immobility time and increased the swimming time but did not alter climbing time in the modified FST. These effects were similar to those of paroxetine (8mg/kg, i.p.), a positive control. Pretreatments with p-chlorophenylalanine (100mg/kg, i.p., an inhibitor of 5-HT synthesis), WAY100635 (0.1mg/kg, s.c., 5-HT1A antagonist), ondansetron (1mg/kg, i.p., a 5-HT3 receptor antagonist), haloperidol (0.2mg/kg, i.p., a non-selective D2 receptor antagonist) and SCH23390 (0.05mg/kg, s.c., a D1 receptor antagonist) were effective to block the antidepressant-like effect of FDPI at a dose of 1mg/kg in the FST. Ritanserin (1mg/kg, i.p., a 5-HT2A/2C receptor antagonist), sulpiride (50mg/kg, i.p., a D2 and D3 receptor antagonist), prazosin (1mg/kg, i.p., an α1 receptor antagonist), yohimbine (1mg/kg, i.p., an α2 receptor antagonist) and propranolol (2mg/kg, i.p., a β receptor antagonist) did not modify the effect of FDPI in the FST. FDPI did not change synaptosomal [(3)H]5-HT uptake. At doses of 10 and 20mg/kg FDPI inhibited MAO-A and MAO-B activities. These results suggest that antidepressant-like effect of FDPI is mediated mostly by serotonergic and dopaminergic systems. Copyright © 2014 Elsevier Inc. All rights reserved.

End product inhibition of hepatic 25-hydroxyvitamin D production in the rat: specificity and kinetics

International Nuclear Information System (INIS)

Milne, M.L.; Baran, D.T.

1985-01-01

The role of vitamin D metabolites in the regulation of hepatic 25-hydroxyvitamin D production was investigated by examining the effects of 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, and 24,25-dihydroxyvitamin D on the synthesis of [25- 3 H]hydroxyvitamin D by rachitic rat liver homogenates. Production of [25- 3 H]hydroxyvitamin D was inhibited by 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D, but not by 24,25-dihydroxyvitamin D. 25-Hydroxyvitamin D increased the Km of the vitamin D-25-hydroxylase enzyme(s), while 1,25-dihydroxyvitamin D decreased the Vmax with a Ki of 88.7 ng/ml. Inhibition of hepatic 25-hydroxyvitamin D production by 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D may be another control mechanism to regulate circulating vitamin D levels

Automatic Classification of Attacks on IP Telephony

Directory of Open Access Journals (Sweden)

Jakub Safarik

2013-01-01

Full Text Available This article proposes an algorithm for automatic analysis of attack data in IP telephony network with a neural network. Data for the analysis is gathered from variable monitoring application running in the network. These monitoring systems are a typical part of nowadays network. Information from them is usually used after attack. It is possible to use an automatic classification of IP telephony attacks for nearly real-time classification and counter attack or mitigation of potential attacks. The classification use proposed neural network, and the article covers design of a neural network and its practical implementation. It contains also methods for neural network learning and data gathering functions from honeypot application.

Resolvin D1 and D2 Reverse Lipopolysaccharide-Induced Depression-Like Behaviors Through the mTORC1 Signaling Pathway.

Science.gov (United States)

Deyama, Satoshi; Ishikawa, Yuka; Yoshikawa, Kotomi; Shimoda, Kento; Ide, Soichiro; Satoh, Masamichi; Minami, Masabumi

2017-07-01

Resolvin D1 and D2 are bioactive lipid mediators that are generated from docosahexaenoic acid. Although recent preclinical studies suggest that these compounds have antidepressant effects, their mechanisms of action remain unclear. We investigated mechanisms underlying the antidepressant effects of resolvin D1 and resolvin D2 in lipopolysaccharide (0.8 mg/kg, i.p.)-induced depression model mice using a tail suspension test. I.c.v. infusion of resolvin D1 (10 ng) and resolvin D2 (10 ng) produced antidepressant effects; these effects were significantly blocked by a resolvin D1 receptor antagonist WRW4 (10 µg, i.c.v.) and a resolvin D2 receptor antagonist O-1918 (10 µg, i.c.v.), respectively. The mammalian target of rapamycin complex 1 inhibitor rapamycin (10 mg/kg, i.p.) and a mitogen-activated protein kinase kinase inhibitor U0126 (5 µg, i.c.v.) significantly blocked the antidepressant effects of resolvin D1 and resolvin D2. An AMPA receptor antagonist NBQX (10 mg/kg, i.p.) and a phosphoinositide 3-kinase inhibitor LY294002 (3 µg, i.c.v.) blocked the antidepressant effects of resolvin D1 significantly, but not of resolvin D2. Bilateral infusions of resolvin D1 (0.3 ng/side) or resolvin D2 (0.3 ng/side) into the medial prefrontal cortex or dentate gyrus of the hippocampus produced antidepressant effects. These findings demonstrate that resolvin D1 and resolvin D2 produce antidepressant effects via the mammalian target of rapamycin complex 1 signaling pathway, and that the medial prefrontal cortex and dentate gyrus are important brain regions for these antidepressant effects. These compounds and their receptors may be promising targets for the development of novel rapid-acting antidepressants, like ketamine and scopolamine. © The Author 2017. Published by Oxford University Press on behalf of CINP.

Production process validation of 2-[18F]-fluoro-2-deoxy-D-glucose

International Nuclear Information System (INIS)

Cantero, Miguel; Iglesias, Rocio; Aguilar, Juan; Sau, Pablo; Tardio, Evaristo; Narrillos, Marcos

2003-01-01

The main of validation of production process of 2-[18F]-fluoro-2-deoxi-D-glucose (FDG) was to check: A) equipment's and services implicated in the production process were correctly installed, well documented, and worked properly, and B) production of FDG was done in a repetitive way according to predefined parameters. The main document was the Validation Master Plan, and steps were: installation qualification, operation qualification, process qualification and validation report. After finalization of all tests established in qualification steps without deviations, we concluded that the production process was validated because is done in a repetitive way according predefined parameters (Au)

Fracture rates of IPS Empress all-ceramic crowns--a systematic review.

Science.gov (United States)

Heintze, Siegward D; Rousson, Valentin

2010-01-01

The aim of this study was to evaluate the clinical fracture rate of crowns fabricated with the pressable, leucite-reinforced ceramic IPS Empress, and relate the results to the type of tooth restored. The database SCOPUS was searched for clinical studies involving full-coverage crowns made of IPS Empress. To assess the fracture rate of the crowns in relation to the type of restored tooth and study, Poisson regression analysis was used. Seven clinical studies were identified involving 1,487 adhesively luted crowns (mean observation time: 4.5+/-1.7 years) and 81 crowns cemented with zinc-phosphate cement (mean observation time: 1.6+/-0.8 years). Fifty-seven of the adhesively luted crowns fractured (3.8%). The majority of fractures (62%) occurred between the third and sixth year after placement. There was no significant influence regarding the test center on fracture rate, but the restored tooth type played a significant role. The hazard rate (per year) for crowns was estimated to be 5 in every 1,000 crowns for incisors, 7 in every 1,000 crowns for premolars, 12 in every 1,000 crowns for canines, and 16 in every 1,000 crowns for molars. One molar crown in the zinc-phosphate group fractured after 1.2 years. Adhesively luted IPS Empress crowns showed a low fracture rate for incisors and premolars and a somewhat higher rate for molars and canines. The sample size of the conventionally luted crowns was too small and the observation period too short to draw meaningful conclusions.

Automated Integration of Dedicated Hardwired IP Cores in Heterogeneous MPSoCs Designed with ESPAM

Directory of Open Access Journals (Sweden)

Ed Deprettere

2008-06-01

Full Text Available This paper presents a methodology and techniques for automated integration of dedicated hardwired (HW IP cores into heterogeneous multiprocessor systems. We propose an IP core integration approach based on an HW module generation that consists of a wrapper around a predefined IP core. This approach has been implemented in a tool called ESPAM for automated multiprocessor system design, programming, and implementation. In order to keep high performance of the integrated IP cores, the structure of the IP core wrapper is devised in a way that adequately represents and efficiently implements the main characteristics of the formal model of computation, namely, Kahn process networks, we use as an underlying programming model in ESPAM. We present details about the structure of the HW module, the supported types of IP cores, and the minimum interfaces these IP cores have to provide in order to allow automated integration in heterogeneous multiprocessor systems generated by ESPAM. The ESPAM design flow, the multiprocessor platforms we consider, and the underlying programming (KPN model are introduced as well. Furthermore, we present the efficiency of our approach by applying our methodology and ESPAM tool to automatically generate, implement, and program heterogeneous multiprocessor systems that integrate dedicated IP cores and execute real-life applications.

Software for rapid time dependent ChIP-sequencing analysis (TDCA).

Science.gov (United States)

Myschyshyn, Mike; Farren-Dai, Marco; Chuang, Tien-Jui; Vocadlo, David

2017-11-25

Chromatin immunoprecipitation followed by DNA sequencing (ChIP-seq) and associated methods are widely used to define the genome wide distribution of chromatin associated proteins, post-translational epigenetic marks, and modifications found on DNA bases. An area of emerging interest is to study time dependent changes in the distribution of such proteins and marks by using serial ChIP-seq experiments performed in a time resolved manner. Despite such time resolved studies becoming increasingly common, software to facilitate analysis of such data in a robust automated manner is limited. We have designed software called Time-Dependent ChIP-Sequencing Analyser (TDCA), which is the first program to automate analysis of time-dependent ChIP-seq data by fitting to sigmoidal curves. We provide users with guidance for experimental design of TDCA for modeling of time course (TC) ChIP-seq data using two simulated data sets. Furthermore, we demonstrate that this fitting strategy is widely applicable by showing that automated analysis of three previously published TC data sets accurately recapitulates key findings reported in these studies. Using each of these data sets, we highlight how biologically relevant findings can be readily obtained by exploiting TDCA to yield intuitive parameters that describe behavior at either a single locus or sets of loci. TDCA enables customizable analysis of user input aligned DNA sequencing data, coupled with graphical outputs in the form of publication-ready figures that describe behavior at either individual loci or sets of loci sharing common traits defined by the user. TDCA accepts sequencing data as standard binary alignment map (BAM) files and loci of interest in browser extensible data (BED) file format. TDCA accurately models the number of sequencing reads, or coverage, at loci from TC ChIP-seq studies or conceptually related TC sequencing experiments. TC experiments are reduced to intuitive parametric values that facilitate biologically

Introduction to IP address management

CERN Document Server

Rooney, Tim

2010-01-01

"The book begins with a basic overview of IP networking, followed by chapters describing each of the three core IPAM technologies: IPv4 and IPv6 addressing, DHCP, and DNS. The next three chapters describe IPAM management techniques and practice, followed by chapters on IPv4-IPv6 co-existence, security and the IPAM business case"--

46 CFR 57.06-2 - Production test plate interval of testing.

Science.gov (United States)

2010-10-01

... WELDING AND BRAZING Production Tests § 57.06-2 Production test plate interval of testing. (a) At least one... 46 Shipping 2 2010-10-01 2010-10-01 false Production test plate interval of testing. 57.06-2... follows: (1) When the extent of welding on a single vessel exceeds 50 lineal feet of either or both...

Increasing supported VoIP flows in WMNs through link-based aggregation

CSIR Research Space (South Africa)

Olwal, T

2008-10-01

Full Text Available As Voice over IP (VoIP) becomes a reality, service providers will be able to offer the service to remote and over populated areas that currently are not or are only partially reached by available Public Switched Telephone Network (PSTN...

Variation in enantiospecific attraction of Ips avulsus (Coleoptera: Curculionidae) to the pheromone ipsdienol in Georgia.

Science.gov (United States)

Daniel Miller; Jeremy Allison