WorldWideScience

Sample records for production test 105-528-a

  1. 26 CFR 1.528-4 - Substantiality test.

    Science.gov (United States)

    2010-04-01

    ... 26 Internal Revenue 7 2010-04-01 2010-04-01 true Substantiality test. 1.528-4 Section 1.528-4 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED... residence. Units which are used for purposes auxiliary to residential use (such as laundry areas, swimming...

  2. 26 CFR 1.528-6 - Expenditure test.

    Science.gov (United States)

    2010-04-01

    ... Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED) INCOME TAX (CONTINUED) INCOME TAXES (CONTINUED) Homeowners Associations § 1.528-6 Expenditure test. (a) In general. An...) Insurance premiums on association property; (11) Accountant's fees; (12) Improvement of private property to...

  3. 27 CFR 5.28 - Adoption of predecessor's formulas.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Adoption of predecessor's formulas. 5.28 Section 5.28 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE BUREAU, DEPARTMENT OF THE TREASURY LIQUORS LABELING AND ADVERTISING OF DISTILLED SPIRITS Formulas § 5.28 Adoption of...

  4. 21 CFR 310.528 - Drug products containing active ingredients offered over-the-counter (OTC) for use as an...

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 5 2010-04-01 2010-04-01 false Drug products containing active ingredients offered over-the-counter (OTC) for use as an aphrodisiac. 310.528 Section 310.528 Food and Drugs FOOD AND... drug product. Anise, cantharides, don qual, estrogens, fennel, ginseng, golden seal, gotu kola, Korean...

  5. 12 CFR 528.1a - Supplementary guidelines.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Supplementary guidelines. 528.1a Section 528.1a Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY NONDISCRIMINATION REQUIREMENTS § 528.1a Supplementary guidelines. The Office's policy statement found at 12 CFR 528.9 supplements...

  6. 12 CFR 528.1 - Definitions.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Definitions. 528.1 Section 528.1 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY NONDISCRIMINATION REQUIREMENTS § 528.1 Definitions. As used in this part 528— (a) Application. For purposes of this part, an application for a loan...

  7. 12 CFR 528.2a - Nondiscriminatory appraisal and underwriting.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Nondiscriminatory appraisal and underwriting. 528.2a Section 528.2a Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY NONDISCRIMINATION REQUIREMENTS § 528.2a Nondiscriminatory appraisal and underwriting. (a) Appraisal. No savings...

  8. 12 CFR 528.8 - Complaints.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Complaints. 528.8 Section 528.8 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY NONDISCRIMINATION REQUIREMENTS § 528.8... of Thrift Supervision, Washington, DC 20552 for processing under Office regulations. Complaints...

  9. 29 CFR 528.6 - Review.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Review. 528.6 Section 528.6 Labor Regulations Relating to... MINIMUM WAGE RATES § 528.6 Review. Any employer and, when appropriate, any apprenticeship agency or... order of annulment or withdrawal may obtain review, limited to the question of whether the findings of...

  10. Corrective Action Investigation Plan for Corrective Action Unit 528: Polychlorinated Biphenyls Contamination, Nevada Test Site, Nevada, Rev. 0

    Energy Technology Data Exchange (ETDEWEB)

    U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office

    2003-05-08

    This Corrective Action Investigation Plan contains the U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office's approach to collect the data necessary to evaluate corrective action alternatives appropriate for the closure of Corrective Action Unit (CAU) 528, Polychlorinated Biphenyls Contamination (PCBs), Nevada Test Site (NTS), Nevada, under the Federal Facility Agreement and Consent Order. Located in the southwestern portion of Area 25 on the NTS in Jackass Flats (adjacent to Test Cell C [TCC]), CAU 528 consists of Corrective Action Site 25-27-03, Polychlorinated Biphenyls Surface Contamination. Test Cell C was built to support the Nuclear Rocket Development Station (operational between 1959 and 1973) activities including conducting ground tests and static firings of nuclear engine reactors. Although CAU 528 was not considered as a direct potential source of PCBs and petroleum contamination, two potential sources of contamination have nevertheless been identified from an unknown source in concentrations that could potentially pose an unacceptable risk to human health and/or the environment. This CAU's close proximity to TCC prompted Shaw to collect surface soil samples, which have indicated the presence of PCBs extending throughout the area to the north, east, south, and even to the edge of the western boundary. Based on this information, more extensive field investigation activities are being planned, the results of which are to be used to support a defensible evaluation of corrective action alternatives in the corrective action decision document.

  11. 20 CFR 638.528 - Social Security.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Social Security. 638.528 Section 638.528... TITLE IV-B OF THE JOB TRAINING PARTNERSHIP ACT Center Operations § 638.528 Social Security. The Act provides that students are covered by title II of the Social Security Act (42 U.S.C. 401 et seq.) and shall...

  12. 12 CFR 528.3 - Nondiscrimination in applications.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Nondiscrimination in applications. 528.3 Section 528.3 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY NONDISCRIMINATION REQUIREMENTS § 528.3 Nondiscrimination in applications. (a) No savings association may discourage, or refuse to...

  13. 6 CFR 5.28 - Preservation of records.

    Science.gov (United States)

    2010-01-01

    ... 6 Domestic Security 1 2010-01-01 2010-01-01 false Preservation of records. 5.28 Section 5.28 Domestic Security DEPARTMENT OF HOMELAND SECURITY, OFFICE OF THE SECRETARY DISCLOSURE OF RECORDS AND INFORMATION Privacy Act § 5.28 Preservation of records. Each component will preserve all correspondence...

  14. 46 CFR 105.05-2 - Prohibitions regarding petroleum products.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Prohibitions regarding petroleum products. 105.05-2... VESSELS COMMERCIAL FISHING VESSELS DISPENSING PETROLEUM PRODUCTS Application § 105.05-2 Prohibitions regarding petroleum products. (a) Commercial fishing vessels shall not transport Grade A flammable liquids...

  15. 29 CFR 528.2 - Definition of terms.

    Science.gov (United States)

    2010-07-01

    ... ESTABLISHMENTS AT SPECIAL MINIMUM WAGE RATES § 528.2 Definition of terms. As used in the regulations contained in... 29 Labor 3 2010-07-01 2010-07-01 false Definition of terms. 528.2 Section 528.2 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR REGULATIONS ANNULMENT OR...

  16. 12 CFR 528.4 - Nondiscriminatory advertising.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Nondiscriminatory advertising. 528.4 Section... REQUIREMENTS § 528.4 Nondiscriminatory advertising. No savings association may directly or indirectly engage in any form of advertising that implies or suggests a policy of discrimination or exclusion in violation...

  17. 31 CFR 560.528 - Aircraft safety.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 3 2010-07-01 2010-07-01 false Aircraft safety. 560.528 Section 560..., Authorizations and Statements of Licensing Policy § 560.528 Aircraft safety. Specific licenses may be issued on a... the safety of civil aviation and safe operation of U.S.-origin commercial passenger aircraft. ...

  18. 12 CFR 528.5 - Equal Housing Lender Poster.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Equal Housing Lender Poster. 528.5 Section 528... REQUIREMENTS § 528.5 Equal Housing Lender Poster. (a) Each savings association shall post and maintain one or more Equal Housing Lender Posters, the text of which is prescribed in paragraph (b) of this section, in...

  19. 46 CFR 111.105-45 - Vessels carrying agricultural products.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Vessels carrying agricultural products. 111.105-45... ENGINEERING ELECTRIC SYSTEMS-GENERAL REQUIREMENTS Hazardous Locations § 111.105-45 Vessels carrying agricultural products. (a) The following areas are Class II, Division 1, (Zone 10 or Z) locations on vessels...

  20. 46 CFR 105.45-1 - Loading or dispensing petroleum products.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Loading or dispensing petroleum products. 105.45-1... VESSELS COMMERCIAL FISHING VESSELS DISPENSING PETROLEUM PRODUCTS Special Operating Requirements § 105.45-1 Loading or dispensing petroleum products. (a) A commercial fishing vessel must have aboard a letter of...

  1. 21 CFR 58.105 - Test and control article characterization.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Test and control article characterization. 58.105... GENERAL GOOD LABORATORY PRACTICE FOR NONCLINICAL LABORATORY STUDIES Test and Control Articles § 58.105 Test and control article characterization. (a) The identity, strength, purity, and composition or other...

  2. 12 CFR 528.6 - Loan application register.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Loan application register. 528.6 Section 528.6 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY NONDISCRIMINATION... Mortgage Disclosure Act Loan Application Registers with the Office of Thrift Supervision in accordance with...

  3. 12 CFR 528.2 - Nondiscrimination in lending and other services.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Nondiscrimination in lending and other services. 528.2 Section 528.2 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF THE TREASURY NONDISCRIMINATION REQUIREMENTS § 528.2 Nondiscrimination in lending and other services. (a) No savings association...

  4. 41 CFR 105-60.605 - Procedure in the event of a demand for production or disclosure.

    Science.gov (United States)

    2010-07-01

    .... (2) Production of material. When information other than oral testimony is sought by a demand, the... of a demand for production or disclosure. 105-60.605 Section 105-60.605 Public Contracts and Property... MATERIALS 60.6-Production or Disclosure by Present or Former General Services Administration Employees in...

  5. 77 FR 54805 - Revocation of Jet Route J-528; WA

    Science.gov (United States)

    2012-09-06

    ...-0749; Airspace Docket No. 11-ANM-29] RIN 2120-AA66 Revocation of Jet Route J-528; WA AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action removes Jet Route J-528... 20591; telephone: (202) 267-8783. SUPPLEMENTARY INFORMATION: Background Jet Route J-528 is currently...

  6. 7,528 patients treated with PCI - a Scandinavian real-life scenario

    DEFF Research Database (Denmark)

    Pedersen, S.; Galatius, S.; Bech, J.

    2008-01-01

    AIM: Analyze clinical, temporal and procedural characteristics from 7,528 consecutive percutaneous coronary intervention (PCI) patients in one of the largest published contemporary European PCI-database during a 6-year period. METHOD: Retrospective study design. Period: 1998-2004. Temporal...... and referral changes in a Danish PCI-registry were analyzed. Demographic and angiographic variables were compared with data from randomized clinical trials, US-registries and current guidelines. RESULTS: 22,214 patients were examined with coronary angiography and 7,528 patients were treated with PCI....... The annual number of PCI's increased by 15%. Over time, the fraction of patients with risk factors increased, median age increased from 61 to 64 years and the coronary pathology was significantly worsened. ST-elevation myocardial infarction patients primarily admitted to hospitals without facilities...

  7. Final report on Production Test No. 105-245-P -- Effectiveness of cadmium coated splines

    Energy Technology Data Exchange (ETDEWEB)

    Carson, A.B.

    1949-05-19

    This report discussed cadmium coated splines which have been developed to supplement the regular control rod systems under emergency shutdown conditions from higher power levels. The objective of this test was to determine the effectiveness of one such spline placed in a tube in the central zone of a pile, and of two splines in the same tube. In addition, the process control group of the P Division asked that probable spline requirements for safe operation at various power levels be estimated, and the details included in this report. The results of the test indicated a reactivity value of 10.5 {plus_minus} 1.0 ih for a single spline, and 19.0 ih {plus_minus} 1.0 ihfor two splines in tube 1674-B under the loading conditions of 4-27-49, the date of the test. The temperature rise of the cooling water for this tube under these conditions was found to be 37.2{degrees}C for 275 MW operation.

  8. CLOSURE REPORT FOR CORRECTIVE ACTION UNIT 528: POLYCHLORINATED BIPHENYLS CONTAMINATION NEVADA TEST SITE, NEVADA

    Energy Technology Data Exchange (ETDEWEB)

    BECHTEL NEVADA

    2006-09-01

    This Closure Report (CR) describes the closure activities performed at CAU 528, Polychlorinated Biphenyls Contamination, as presented in the Nevada Division of Environmental Protection (NDEP)-approved Corrective Action Plan (CAP) (US. Department of Energy, National Nuclear Security Administration Nevada Site Office [NNSAINSO], 2005). The approved closure alternative was closure in place with administrative controls. This CR provides a summary of the completed closure activities, documentation of waste disposal, and analytical data to confirm that the remediation goals were met.

  9. 30 CFR 210.105 - May I submit these production reports manually?

    Science.gov (United States)

    2010-07-01

    ... addressed to Minerals Management Service, P.O. Box 17110, Denver, Colorado 80217-0110; or (2) Special... 30 Mineral Resources 2 2010-07-01 2010-07-01 false May I submit these production reports manually? 210.105 Section 210.105 Mineral Resources MINERALS MANAGEMENT SERVICE, DEPARTMENT OF THE INTERIOR...

  10. 46 CFR 105.05-1 - Commercial fishing vessels dispensing petroleum products.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Commercial fishing vessels dispensing petroleum products... MISCELLANEOUS VESSELS COMMERCIAL FISHING VESSELS DISPENSING PETROLEUM PRODUCTS Application § 105.05-1 Commercial fishing vessels dispensing petroleum products. (a) The provisions of this part, with the exception of...

  11. 40 CFR 80.528-80.529 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... (CONTINUED) REGULATION OF FUELS AND FUEL ADDITIVES Motor Vehicle Diesel Fuel; Nonroad, Locomotive, and Marine Diesel Fuel; and ECA Marine Fuel Motor Vehicle Diesel Fuel Standards and Requirements §§ 80.528-80.529...

  12. Characterization of spent fuel approved testing material---ATM-105

    Energy Technology Data Exchange (ETDEWEB)

    Guenther, R.J.; Blahnik, D.E.; Campbell, T.K.; Jenquin, U.P.; Mendel, J.E.; Thomas, L.E.; Thornhill, C.K.

    1991-12-01

    The characterization data obtained to data are described for Approved Testing Material 105 (ATM-105), which is spent fuel from Bundles CZ346 and CZ348 of the Cooper Nuclear Power Plant, a boiling-water reactor. This report is one in a series being prepared by the Materials Characterization Center at Pacific Northwest Laboratory (PNL) on spent fuel ATMs. The ATMs are receiving extensive examinations to provide a source of well-characterized spent fuel for testing in the US Department of Energy Office of Civilian Radioactive Waste Management (OCRWM) Program. ATM-105 consists of 88 full-length irradiated fuel rods with rod-average burnups of about 2400 GJ/kgM (28 MWd/kgM) and expected fission gas release of about 1%. Characterization data include (1) descriptions of as-fabricated fuel design, irradiation history, and subsequent storage and handling; (2) isotopic gamma scans; (3) fission gas analyses; (4) ceramography of the fuel and metallography of the cladding; (5) special fuel studies involving analytical transmission electron microscopy (AEM); (6) calculated nuclide inventories and radioactivities in the fuel and cladding; and (7) radiochemical analyses of the fuel and cladding. Additional analyses of the fuel are being conducted and will be included in planned revisions of this report.

  13. 46 CFR 105.90-1 - Existing commercial fishing vessels dispensing petroleum products.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Existing commercial fishing vessels dispensing petroleum... AND MISCELLANEOUS VESSELS COMMERCIAL FISHING VESSELS DISPENSING PETROLEUM PRODUCTS Existing Commercial Fishing Vessels Dispensing Petroleum Products § 105.90-1 Existing commercial fishing vessels dispensing...

  14. 9 CFR 3.105 - Feeding.

    Science.gov (United States)

    2010-01-01

    ... Mammals Animal Health and Husbandry Standards § 3.105 Feeding. (a) The food for marine mammals must be... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Feeding. 3.105 Section 3.105 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE ANIMAL...

  15. 105-KE basin pilot run relocation

    International Nuclear Information System (INIS)

    Crystal, J.B.

    1994-01-01

    The purpose of this document is to present the bases for selecting the exact in-facility location for installation of process equipment to support pilot testing activities in the 105-KE Basin at the United States Department of Energy Hanford Site, in southeastern Washington State. The 105-KE Basin was constructed during the early 1950s, as an integralcomponent of the 105-K East reactor building. Similar basins were provided in all Hanford weapons production reactor buildings to receive fuel elements discharged from the reactors and stage them for rail transport to 200 Area fuel reprocessing plants. The 105-KE reactor began operation in 1955. It was shut down in 1971. However, the 105-KE Basin was reactivated several years later to store spent fuel from the N-Reactor basin and permit its continued operation during outages at the Plutonium Uranium Extraction (PUREX) plant in the 200E Area

  16. Optimization of extracellular polysaccharide production in ...

    African Journals Online (AJOL)

    sunny

    2014-11-26

    Nov 26, 2014 ... Llamas I (2007). Characterization of exopolysaccharides produced by three moderately halophilic bacteria belonging to the family. Alteromonadaceae. J. Appl. Microbiol. 105:521-528. Mishra, Jha (2013). Microbial Exopolysaccharides In: Rosenberg, E.,. The Prokaryotes –Applied Bacteriology and ...

  17. 48 CFR 528.311 - Solicitation provision and contract clause on liability insurance under cost-reimbursement...

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Solicitation provision and contract clause on liability insurance under cost-reimbursement contracts. 528.311 Section 528.311 Federal...-reimbursement contracts. ...

  18. 46 CFR 105.10-15 - Flammable liquid.

    Science.gov (United States)

    2010-10-01

    ... FISHING VESSELS DISPENSING PETROLEUM PRODUCTS Definition of Terms Used in This Part § 105.10-15 Flammable... vapor pressure of 14 pounds or more. 1 American Society of Testing Materials Standard D 323...

  19. 105K West Isolation Barrier Acceptance Test results

    International Nuclear Information System (INIS)

    McCracken, K.J.; Irwin, J.J.

    1995-01-01

    The objective of this document is to report and interpret the findings of the isolation barrier acceptance tests performed in 105KW/100K. The tests were performed in accordance with the test plan and acceptance test procedure. The test report contains the test data. This document compares the test data against the criteria. A discussion of the leak rate analytical characterization describes how the flow characteristics flow rate will be determined using the test data from the test report. Two modes of water loss were considered; basin and/or discharge chute leakage, and evaporation. An initial test established baseline leakage data and instrumentation performance. Test 2 evaluated the sealing performance of the isolation barrier by inducing an 11 in. (27.9 cm) level differential across the barrier. The leak rate at this 11 in. (27.9 cm) level is extrapolated to the 16 ft. (4.9 m) level differential postulated in the DBE post seismic event. If the leak rate, adjusted for evaporation and basin leakage (determined from Test 1), is less than the SAR limit of 1,500 gph (5,680 lph) at a 16 ft (4.9 m) level differential, the barriers pass the acceptance test

  20. A comparison of theory and flight test of the BO 105/BMR in hover and forward flight

    Science.gov (United States)

    Mirick, Paul H.

    1988-01-01

    Four cases were selected for comparison with theoretical predictions using stability data obtained during the flight test of the Bearingless Main Rotor (BMR) on a Messerschmidt-Boelkow-Blohm BO 105 helicopter. The four cases selected form the flight test included two ground resonance cases and two air resonance cases. The BMR used four modified BO 105 blades attached to a bearingless hub. The hub consisted of dual fiberglass C-channel beams attached to the hub center at 0.0238R and attached to the blade root at 0.25R with blade pitch control provided by a torque tube. Analyses from Bell Helicopter Textron, Boeing Vertol, and Sikorsky Aircraft were compared with the data and the correlation ranged from very poor-to-poor to poor-to-fair.

  1. 26 CFR 1.528-2 - Organized and operated to provide for the acquisition, construction, management, maintenance and...

    Science.gov (United States)

    2010-04-01

    ... acquisition, construction, management, maintenance and care of association property. 1.528-2 Section 1.528-2... acquisition, construction, management, maintenance and care of association property. (a) Organized and... association are the acquisition, construction, management, maintenance, and care of association property. In...

  2. 105 K east ion exchange and cartridge filter restart instrumentation acceptance test report

    International Nuclear Information System (INIS)

    Whitehurst, R.

    1996-01-01

    Acceptance Test Report following the completion of ATP-012 for the 105KE CP-A and CP-A Computer and PLC Panels. The test was conducted from 11/13/95 to 12/11/95. Three test discrepancies were generated during the ATP and all were dispositioned and closed. All sections were completed except Section 5.9 which was deleted per ECN 190556

  3. Proposal of how to update the standard information requirements in REACH, PPPR and BPR – a testing strategy for identification of endocrine disruptors

    DEFF Research Database (Denmark)

    Holbech, Henrik; Bjerregaard, Poul; Hass, Ulla

    to these, new test methods that include endocrine sensitive endpoints have been included with regard to human health and the environment. Similar data requirements and new test methods that include endocrine sensitive endpoints are included in the guidance on Regulation (EU) No 528/2012 on how to fulfil...... review on EDs and the revised strategy for the future work on endocrine disruptors, focusing on adequate detection of substances with endocrine disrupting properties under various legislative frameworks, including REACH (EC No 1907/2006), the Plant Protection Products Regulation (PPPR) (EC No 1107....../2009) and the Biocidal Products Regulation (BPR) (EC No 528/2012). There are currently no specific information requirements or testing strategies with regard to endocrine disruption in REACH and other relevant legislations. However, in relation to biocides and recently also to plant protection products, indications...

  4. 40 CFR 94.105 - Duty cycles.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Duty cycles. 94.105 Section 94.105... EMISSIONS FROM MARINE COMPRESSION-IGNITION ENGINES Test Procedures § 94.105 Duty cycles. (a) Overview. For....8(e), engines shall be tested using the appropriate duty cycles described in this section. (b...

  5. 46 CFR 105.20-10 - Pumps.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Pumps. 105.20-10 Section 105.20-10 Shipping COAST GUARD... DISPENSING PETROLEUM PRODUCTS Specific Requirements-Cargo Tanks § 105.20-10 Pumps. (a) Pumps for cargo... discharge side of pump if the pressure under shutoff conditions exceeds 60 pounds. When a relief valve is...

  6. 45 CFR 164.528 - Accounting of disclosures of protected health information.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Accounting of disclosures of protected health... Health Information § 164.528 Accounting of disclosures of protected health information. (a) Standard: Right to an accounting of disclosures of protected health information. (1) An individual has a right to...

  7. 46 CFR 105.45-10 - Smoking.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Smoking. 105.45-10 Section 105.45-10 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CARGO AND MISCELLANEOUS VESSELS COMMERCIAL FISHING VESSELS DISPENSING PETROLEUM PRODUCTS Special Operating Requirements § 105.45-10 Smoking. (a) Smoking is prohibited during and in the vicinity of the...

  8. 7 CFR 70.105 - Procedures for appeal gradings.

    Science.gov (United States)

    2010-01-01

    ... conducting the appeal grading. Whether defrosting poultry or rabbit carcasses for other types of appeals will... 7 Agriculture 3 2010-01-01 2010-01-01 false Procedures for appeal gradings. 70.105 Section 70.105... PRODUCTS AND RABBIT PRODUCTS Grading of Poultry Products and Rabbit Products Appeal of A Grading Or...

  9. 9 CFR 113.105 - Leptospira Hardjo Bacterin.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Leptospira Hardjo Bacterin. 113.105... Inactivated Bacterial Products § 113.105 Leptospira Hardjo Bacterin. Leptospira Hardjo Bacterin shall be produced from a culture of Leptospira hardjo which has been inactivated and is nontoxic. Each serial of...

  10. DPRK's 4"t"h Nuclear Test and its Tritium Production

    International Nuclear Information System (INIS)

    Kim, Min Soo; Lee, Sang Joon; Chang, Sun Young

    2016-01-01

    On January 6, 2016 at 10:30am, the artificial earthquake in the DPRK was detected by multiple international seismic organizations. After 2 hours, the DPRK announced on state TV that 'The first H-bomb test was successfully conducted in the DPRK at 10:00 am on Wednesday, Juche 105(2016), pursuant to the strategic determination of the ruling communist party.' There has been a doubt about the real nature of the DPRK's 4th nuclear test, since 2 months have been passed after its nuclear test. To analyze the nature of the DPRK's nuclear test, it is necessary to check possible options for production of essential materials. The pathways to produce nuclear fusion material (tritium) and to have a relatively high possibility for the DPRK are described in this article. Tritium is key material for H-bomb. And there are two options for the DPRK which are 1) production and 2) illicit trafficking. And this study is focused on production possibility of DPRK. Determination of the nature of DPRK's nuclear test is very hard issue

  11. 27 CFR 25.105 - Release of collateral security.

    Science.gov (United States)

    2010-04-01

    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Release of collateral security. 25.105 Section 25.105 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND TRADE... of Bonds Or Consents of Surety § 25.105 Release of collateral security. Bonds, notes, and other...

  12. 46 CFR 105.45-5 - Galley fires.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Galley fires. 105.45-5 Section 105.45-5 Shipping COAST... VESSELS DISPENSING PETROLEUM PRODUCTS Special Operating Requirements § 105.45-5 Galley fires. (a) Galley fires are normally permitted during cargo transfer operations. However, prior to transferring Grade B or...

  13. 46 CFR 105.35-5 - Fire pumps.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Fire pumps. 105.35-5 Section 105.35-5 Shipping COAST... VESSELS DISPENSING PETROLEUM PRODUCTS Fire Extinguishing Equipment § 105.35-5 Fire pumps. (a) All vessels shall be provided with a hand operated portable fire pump having a capacity of at least 5 gallons per...

  14. 14 CFR 1263.105 - Considerations in determining whether production or disclosure should be made.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Considerations in determining whether... § 1263.105 Considerations in determining whether production or disclosure should be made. The General...) Whether disclosure might improperly reveal trade secrets, or commercial or financial information that is...

  15. CESIUM REMOVAL FROM TANKS 241-AN-103 & 241-SX-105 & 241-AZ-101 & 241AZ-102 COMPOSITE FOR TESTING IN BENCH SCALE STEAM REFORMER

    Energy Technology Data Exchange (ETDEWEB)

    DUNCAN JB; HUBER HJ

    2011-04-21

    This report documents the preparation of three actual Hanford tank waste samples for shipment to the Savannah River National Laboratory (SRNL). Two of the samples were dissolved saltcakes from tank 241-AN-103 (hereafter AN-103) and tank 241-SX-105 (hereafter SX-105); one sample was a supernate composite from tanks 241-AZ-101 and 241-AZ-102 (hereafter AZ-101/102). The preparation of the samples was executed following the test plans LAB-PLAN-10-00006, Test Plan for the Preparation of Samples from Hanford Tanks 241-SX-105, 241-AN-103, 241-AN-107, and LAB-PLN-l0-00014, Test Plan for the Preparation of a Composite Sample from Hanford Tanks 241-AZ-101 and 241-AZ-102 for Steam Reformer Testing at the Savannah River National Laboratory. All procedural steps were recorded in laboratory notebook HNF-N-274 3. Sample breakdown diagrams for AN-103 and SX-105 are presented in Appendix A. The tank samples were prepared in support of a series of treatability studies of the Fluidized Bed Steam Reforming (FBSR) process using a Bench-Scale Reformer (BSR) at SRNL. Tests with simulants have shown that the FBSR mineralized waste form is comparable to low-activity waste glass with respect to environmental durability (WSRC-STI-2008-00268, Mineralization of Radioactive Wastes by Fluidized Bed Steam Reforming (FBSR): Comparisons to Vitreous Waste Forms and Pertinent Durability Testing). However, a rigorous assessment requires long-term performance data from FBSR product formed from actual Hanford tank waste. Washington River Protection Solutions, LLC (WRPS) has initiated a Waste Form Qualification Program (WP-5.2.1-2010-001, Fluidized Bed Steam Reformer Low-level Waste Form Qualification) to gather the data required to demonstrate that an adequate FBSR mineralized waste form can be produced. The documentation of the selection process of the three tank samples has been separately reported in RPP-48824, Sample Selection Process for Bench-Scale Steam Reforming Treatability Studies Using

  16. 19 CFR 357.105 - Questionnaires.

    Science.gov (United States)

    2010-04-01

    ... 19 Customs Duties 3 2010-04-01 2010-04-01 false Questionnaires. 357.105 Section 357.105 Customs... Questionnaires. For reviews conducted under section 106(b)(2), the Secretary normally will send questionnaires to potential producers/suppliers of the product to determine whether it is in short supply. Questionnaires...

  17. 49 CFR 236.105 - Electric lock.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Electric lock. 236.105 Section 236.105 Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION...: All Systems Inspections and Tests; All Systems § 236.105 Electric lock. Electric lock, except forced...

  18. 41 CFR 105-69.105 - Definitions.

    Science.gov (United States)

    2010-07-01

    ... services in the private sector. (o) Recipient includes all contractors, subcontractors at any tier, and... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Definitions. 105-69.105... RESTRICTIONS ON LOBBYING General § 105-69.105 Definitions. For purposes of this part: (a) Agency, as defined in...

  19. 105-KE Basin isolation barrier leak rate test analytical development. Revision 1

    International Nuclear Information System (INIS)

    Irwin, J.J.

    1995-01-01

    This document provides an analytical development in support of the proposed leak rate test of the 105-KE Basin. The analytical basis upon which the K-basin leak test results will be used to determine the basin leakage rates is developed in this report. The leakage of the K-Basin isolation barriers under postulated accident conditions will be determined from the test results. There are two fundamental flow regimes that may exist in the postulated K-Basin leakage: viscous laminar and turbulent flow. An analytical development is presented for each flow regime. The basic geometry and nomenclature of the postulated leak paths are denoted

  20. 48 CFR 17.105-2 - Objectives.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Objectives. 17.105-2 Section 17.105-2 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACTING METHODS... contracts. (d) Substantial continuity of production or performance, thus avoiding annual startup costs...

  1. Production of the isotope /sup 105/In and investigation of the decay /sup 105/In. -->. /sup 105/Cd

    Energy Technology Data Exchange (ETDEWEB)

    Rivier, J; Moret, R [Institut des Sciences Nucleaires, 38 - Grenoble (France)

    1975-01-01

    A new isotope, /sup 105/In, was produced by means of the reaction /sup 106/Cd(p,2n). The half-life of the ground state is 5.1 +- 0.3 min. There is an isomeric level at 674.1 keV (T/sub 1/2/ = 55 +- 5 sec). Thirty-two transitions have been found, and a decay scheme has been set up through a study of the ..gamma.. spectrum and by coincidence techniques.

  2. Cesium Removal From Tanks 241-AN-103 and 241-SX-105 and 241-AZ-101 and 241-AZ-102 Composite For Testing In Bench Scale Steam Reformer

    International Nuclear Information System (INIS)

    Duncan, J.B.; Huber, H.J.

    2011-01-01

    This report documents the preparation of three actual Hanford tank waste samples for shipment to the Savannah River National Laboratory (SRNL). Two of the samples were dissolved saltcakes from tank 241-AN-103 (hereafter AN-103) and tank 241-SX-105 (hereafter SX-105); one sample was a supernate composite from tanks 241-AZ-101 and 241-AZ-102 (hereafter AZ-101/102). The preparation of the samples was executed following the test plans LAB-PLAN-10-00006, Test Plan for the Preparation of Samples from Hanford Tanks 241-SX-105, 241-AN-103, 241-AN-107, and LAB-PLN-l0-00014, Test Plan for the Preparation of a Composite Sample from Hanford Tanks 241-AZ-101 and 241-AZ-102 for Steam Reformer Testing at the Savannah River National Laboratory. All procedural steps were recorded in laboratory notebook HNF-N-274 3. Sample breakdown diagrams for AN-103 and SX-105 are presented in Appendix A. The tank samples were prepared in support of a series of treatability studies of the Fluidized Bed Steam Reforming (FBSR) process using a Bench-Scale Reformer (BSR) at SRNL. Tests with simulants have shown that the FBSR mineralized waste form is comparable to low-activity waste glass with respect to environmental durability (WSRC-STI-2008-00268, Mineralization of Radioactive Wastes by Fluidized Bed Steam Reforming (FBSR): Comparisons to Vitreous Waste Forms and Pertinent Durability Testing). However, a rigorous assessment requires long-term performance data from FBSR product formed from actual Hanford tank waste. Washington River Protection Solutions, LLC (WRPS) has initiated a Waste Form Qualification Program (WP-5.2.1-2010-001, Fluidized Bed Steam Reformer Low-level Waste Form Qualification) to gather the data required to demonstrate that an adequate FBSR mineralized waste form can be produced. The documentation of the selection process of the three tank samples has been separately reported in RPP-48824, Sample Selection Process for Bench-Scale Steam Reforming Treatability Studies Using

  3. Operational Test Report (OTR) for U-105 Pumping and Instrumentation and Control (PIC) Skid

    International Nuclear Information System (INIS)

    KOCH, M.R.

    2000-01-01

    Attached is the completed Operation Test Procedure (OTP-200-004, Rev. A-18). OTP includes a print out of the Programmable Logic Controller (PLC) Ladder Diagram. Ladder Diagram was designed for installation in the PLC used to monitor and control pumping activity for Tank Farm 241-U-105. The completed OTP and OTR are referenced in the IS PIC Skid Configuration Drawing (H-2-829998)

  4. Operational Test Report (OTR) for U-105 Pumping and Instrumentation and Control (PIC) Skid

    Energy Technology Data Exchange (ETDEWEB)

    KOCH, M.R.

    2000-02-28

    Attached is the completed Operation Test Procedure (OTP-200-004, Rev. A-18). OTP includes a print out of the Programmable Logic Controller (PLC) Ladder Diagram. Ladder Diagram was designed for installation in the PLC used to monitor and control pumping activity for Tank Farm 241-U-105. The completed OTP and OTR are referenced in the IS PIC Skid Configuration Drawing (H-2-829998).

  5. DPRK's 4{sup th} Nuclear Test and its Tritium Production

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Min Soo; Lee, Sang Joon; Chang, Sun Young [Korea Institute of Nuclear Nonproliferation and Control, Daejeon (Korea, Republic of)

    2016-05-15

    On January 6, 2016 at 10:30am, the artificial earthquake in the DPRK was detected by multiple international seismic organizations. After 2 hours, the DPRK announced on state TV that 'The first H-bomb test was successfully conducted in the DPRK at 10:00 am on Wednesday, Juche 105(2016), pursuant to the strategic determination of the ruling communist party.' There has been a doubt about the real nature of the DPRK's 4th nuclear test, since 2 months have been passed after its nuclear test. To analyze the nature of the DPRK's nuclear test, it is necessary to check possible options for production of essential materials. The pathways to produce nuclear fusion material (tritium) and to have a relatively high possibility for the DPRK are described in this article. Tritium is key material for H-bomb. And there are two options for the DPRK which are 1) production and 2) illicit trafficking. And this study is focused on production possibility of DPRK. Determination of the nature of DPRK's nuclear test is very hard issue.

  6. Corrective Action Decision Document/Closure Report for Corrective Action Unit 105: Area 2 Yucca Flat Atmospheric Test Sites, Nevada National Security Site, Nevada, Revision 0

    Energy Technology Data Exchange (ETDEWEB)

    Matthews, Patrick

    2013-09-01

    This Corrective Action Decision Document/Closure Report presents information supporting the closure of Corrective Action Unit (CAU) 105: Area 2 Yucca Flat Atmospheric Test Sites, Nevada National Security Site, Nevada. CAU 105 comprises the following five corrective action sites (CASs): -02-23-04 Atmospheric Test Site - Whitney Closure In Place -02-23-05 Atmospheric Test Site T-2A Closure In Place -02-23-06 Atmospheric Test Site T-2B Clean Closure -02-23-08 Atmospheric Test Site T-2 Closure In Place -02-23-09 Atmospheric Test Site - Turk Closure In Place The purpose of this Corrective Action Decision Document/Closure Report is to provide justification and documentation supporting the recommendation that no further corrective action is needed for CAU 105 based on the implementation of the corrective actions. Corrective action investigation (CAI) activities were performed from October 22, 2012, through May 23, 2013, as set forth in the Corrective Action Investigation Plan for Corrective Action Unit 105: Area 2 Yucca Flat Atmospheric Test Sites; and in accordance with the Soils Activity Quality Assurance Plan, which establishes requirements, technical planning, and general quality practices.

  7. 27 CFR 26.105 - Prepayment of tax-release of beer.

    Science.gov (United States)

    2010-04-01

    ... of beer. 26.105 Section 26.105 Alcohol, Tobacco Products and Firearms ALCOHOL AND TOBACCO TAX AND... ISLANDS Taxpayment of Liquors and Articles in Puerto Rico Beer § 26.105 Prepayment of tax—release of beer. (a) Action by brewer. Where the beer is to be withdrawn from bonded storage after payment of the...

  8. 21 CFR 20.105 - Testing and research conducted by or with funds provided by the Food and Drug Administration.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Testing and research conducted by or with funds... Categories of Records § 20.105 Testing and research conducted by or with funds provided by the Food and Drug Administration. (a) Any list that may be prepared by the Food and Drug Administration of testing and research...

  9. Evaluation of Alternative Methods for Testing the Bioefficacy of Household Ambient Insecticide Products Against Aedes albopictus.

    Science.gov (United States)

    Cassini, Rudi; Scremin, Mara; Contiero, Barbara; Drago, Andrea; Vettorato, Christian; Marcer, Federica; di Regalbono, Antonio Frangipane

    2016-06-01

    Ambient insecticides are receiving increasing attention in many developed countries because of their value in reducing mosquito nuisance. As required by the European Union Biocidal Products Regulation 528/2012, these devices require appropriate testing of their efficacy, which is based on estimating the knockdown and mortality rates of free-flying (free) mosquitoes in a test room. However, evaluations using free mosquitoes present many complexities. The performances of 6 alternative methods with mosquitoes held in 2 different cage designs (steel wire and gauze/plastic) with and without an operating fan for air circulation were monitored in a test room through a closed-circuit television system and were compared with the currently recommended method using free mosquitoes. Results for caged mosquitoes without a fan showed a clearly delayed knockdown effect, whereas outcomes for caged mosquitoes with a fan recorded higher mortality at 24 h, compared to free mosquitoes. Among the 6 methods, cages made of gauze and plastic operating with fan wind speed at 2.5-2.8 m/sec was the only method without a significant difference in results for free mosquitoes, and therefore appears as the best alternative to assess knockdown by ambient insecticides accurately.

  10. Integrated Advanced Microwave Sounding Unit-A (AMSU-A). Performance Verification Report: Initial Comprehensive Performance Test Report, P/N 1331200-2-IT, S/N 105/A2

    Science.gov (United States)

    Platt, R.

    1999-01-01

    This is the Performance Verification Report, Initial Comprehensive Performance Test Report, P/N 1331200-2-IT, S/N 105/A2, for the Integrated Advanced Microwave Sounding Unit-A (AMSU-A). The specification establishes the requirements for the Comprehensive Performance Test (CPT) and Limited Performance Test (LPT) of the Advanced Microwave Sounding, Unit-A2 (AMSU-A2), referred to herein as the unit. The unit is defined on Drawing 1331200. 1.2 Test procedure sequence. The sequence in which the several phases of this test procedure shall take place is shown in Figure 1, but the sequence can be in any order.

  11. Development, validation, and application of ELISA for detection of anti-HD105 antibodies in pre-clinical safety evaluation using monkeys.

    Science.gov (United States)

    Choi, Woo Hyuck; Jo, Hye Ryun; Jeon, Eun-Jeong; Youm, So-Young; Jeon, Jang Su; Son, Yong-Gyu; You, Weon-Kyoo; Koh, Woo Suk; Lee, Sang Hoon; Kim, Sang Kyum

    2016-11-30

    Unwanted immunogenicity of protein therapeutics can result in severe side effects and should be assessed in animals before applying the treatment to humans. Monkeys are the most relevant choice for pre-clinical toxicity testing of antibody-based therapeutics. To assess the immunogenicity of HD105, a novel antibody therapeutic that targets both vascular endothelial growth factor and Delta-like-ligand 4, a bridging enzyme-linked immunosorbent assay was developed as an anti-drug antibody (ADA) assay and validated for use in pre-clinical studies using non-human primates. This method was found to have suitable assay sensitivity, intra- and inter-assay precision, confirmation, drug tolerance, recovery, and sample stability for measuring ADA in monkey serum samples. The results showed that ADA elevation occurred following repeated doses of HD105, and that ADA production was negatively associated with serum HD105 concentration. These results suggest that intravenous administration of HD105 induces production of ADA in monkeys and that the detection of ADA may be negatively influenced by free HD105 in serum. Copyright © 2016 Elsevier B.V. All rights reserved.

  12. 10 CFR 71.105 - Quality assurance program.

    Science.gov (United States)

    2010-01-01

    ... which functional compliance can be demonstrated by inspection or test; and (5) The quality history and... 10 Energy 2 2010-01-01 2010-01-01 false Quality assurance program. 71.105 Section 71.105 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) PACKAGING AND TRANSPORTATION OF RADIOACTIVE MATERIAL Quality...

  13. Corrective Action Investigation Plan for Corrective Action Unit 500: Test Cell A Septic System, Nevada Test Site, Nevada, Revision 0, DOE/NV--528 UPDATED WITH TECHNICAL CHANGE No.1

    Energy Technology Data Exchange (ETDEWEB)

    ITLV

    1998-12-01

    This Corrective Action Investigation Plan (CAIP) addresses one of three leachfield systems associated with Test Cell A, which is located in Area 25 at the Nevada Test Site (NTS). The NTS is approximately 105 kilometers (km) (65 miles [mi]) northwest of Las Vegas, Nevada (see Leachfield Work Plan Figure 1-1). Corrective Action Unit 500 is comprised of the Test Cell A Septic System (CAS 25-04-05) and the associated leachfield system presented in Figure 1-1 (FFACO, 1996). The leachfield is located 60 meters (m) (200 feet [ft]) southeast of the Building 3124 gate, and approximately 45 m (150 ft) southwest of Building 3116 at Test Cell A. Test Cell A operated during the 1960s to support nuclear rocket reactor testing as part of the Nuclear Rocket Development Station (NRDS) (SNPO, 1970). Various operations within Buildings 3113B (Mechanical Equipment Room), 3115 (Helium Compressor Station), 3116 (Pump House), a water tank drain and overflow, a ''yard and equipment drain system'' outside of Building 3116, and a trailer have resulted in potentially hazardous effluent releases to the leachfield system (DOE, 1988a). The leachfield system components include discharge lines, manways, a septic tank, an outfall line, a diversion chamber, and a 15 by 30 m (50 by 100 ft) leachfield (see Leachfield Work Plan Figure 3-1 for explanation of terminology). In addition, engineering drawings show an outfall system that may or may not be connected to the CAU 500 leachfield. In general, effluent contributed to the leachfield was sanitary wastewater associated with floor drains, toilet and lavatory facilities in Building 3113B and floor drains in the remaining source buildings. The surface and subsurface soils in the vicinity of the collection system, outfall, and leachfield may have been impacted by effluent containing contaminants of potential concern (COPCs) generated by support activities associated with Test Cell A reactor testing operations.

  14. Engineering evaluation/cost analysis for the 105-DR and 105-F Reactor facilities and ancillary facilities

    International Nuclear Information System (INIS)

    Coenenberg, E.T.

    1998-01-01

    This document presents the results of an engineering evaluation/cost analysis (EE/CA) that was conducted to evaluate alternatives to address final disposition of the 105-DR and 105-F Reactor Buildings (subsequently referred to as facilities), including the fuel storage basins (FSB) and below-grade portions of the reactors, excluding the reactor blocks. The reactor blocks will remain in a safe storage mode for up to 75 years as identified in the Record the Decision (ROD) (58 FR 48509) for the Environmental Impact Statement (EIS), Decommissioning of Eight Surplus Production Reactors at the Hanford Site, Richland, Washington (DOE 1992a). This EE/CA also addresses final disposition of four ancillary facilities: 116-D and 116-DR Exhaust Air Stacks, 117-DR Exhaust Filter Building, and 119-DR Exhaust Air Sample Building. The 105-DR and 105-F facilities are located in the 100-D and 100-F Areas of the Hanford Site. In November 1989, the 100 Area of the Hanford Site was placed on the U.S. Environmental Protection Agency's (EPA) National Priorities List (NPL) under the Comprehensive Environmental Response, Compensation, and Liability Act of 1980 (CERCLA). The 100 Area NPL includes the 100-D Area (which includes the 100-DR site) and the 100-F Area, which are in various stages of the remediation process. It has been determined by DOE that hazardous substances in the 105-DR, 105-F, and the four ancillary facilities may present a potential threat to human health or the environment, and that a non-time critical removal action at these facilities is warranted. To help determine the most appropriate action, DOE, in cooperation with the Washington State Department of Ecology (Ecology) and the EPA, has prepared this EE/CA. The scope of the evaluation includes the 105-DR and 105-F facilities and the four ancillary facilities. The 116-DR and 117-DR facilities are located within the boundaries of the 105-DR Large Sodium Fire Facility Treatment, Storage, and Disposal (TSD) unit, which is

  15. 105-DR Large Sodium Fire Facility closure plan

    International Nuclear Information System (INIS)

    1993-05-01

    The Hanford Site, located northwest of the city of Richland, Washington, houses reactors, chemical-separation systems, and related facilities used for the production of special nuclear materials, and activities associated with nuclear energy development. The 105-DR Large Sodium Fire Facility (LSFF), which was in operation from about 1972 to 1986, was a research laboratory that occupied the former ventilation supply room on the southwest side of the 105-DR Reactor facility. The LSFF was established to provide a means of investigating fire and safety aspects associated with large sodium or other metal alkali fires in the liquid metal fast breeder reactor (LMFBR) facilities. The 105-DR Reactor facility was designed and built in the 1950's and is located in the 100-D Area of the Hanford Site. The building housed the 105-DR defense reactor, which was shut down in 1964. The LSFF was initially used only for engineering-scale alkali metal reaction studies. In addition, the Fusion Safety Support Studies program sponsored intermediate-size safety reaction tests in the LSFF with lithium and lithium lead compounds. The facility has also been used to store and treat alkali metal waste, therefore the LSFF is subject to the regulatory requirements for the storage and treatment of dangerous waste. Closure will be conducted pursuant to the requirements of the Washington Administrative Code (WAC) 173-303-610. This closure plan presents a description of the facility, the history of waste managed, and the procedures that will be followed to close the LSFF as an Alkali Metal Treatment Facility. No future use of the LSFF is expected

  16. TLR accessory molecule RP105 (CD180 is involved in post-interventional vascular remodeling and soluble RP105 modulates neointima formation.

    Directory of Open Access Journals (Sweden)

    Jacco C Karper

    Full Text Available BACKGROUND: RP105 (CD180 is TLR4 homologue lacking the intracellular TLR4 signaling domain and acts a TLR accessory molecule and physiological inhibitor of TLR4-signaling. The role of RP105 in vascular remodeling, in particular post-interventional remodeling is unknown. METHODS AND RESULTS: TLR4 and RP105 are expressed on vascular smooth muscle cells (VSMC as well as in the media of murine femoral artery segments as detected by qPCR and immunohistochemistry. Furthermore, the response to the TLR4 ligand LPS was stronger in VSMC from RP105(-/- mice resulting in a higher proliferation rate. In RP105(-/- mice femoral artery cuff placement resulted in an increase in neointima formation as compared to WT mice (4982 ± 974 µm(2 vs.1947 ± 278 µm(2,p = 0.0014. Local LPS application augmented neointima formation in both groups, but in RP105(-/- mice this effect was more pronounced (10316±1243 µm(2 vs.4208 ± 555 µm(2,p = 0.0002, suggesting a functional role for RP105. For additional functional studies, the extracellular domain of murine RP105 was expressed with or without its adaptor protein MD1 and purified. SEC-MALSanalysis showed a functional 2∶2 homodimer formation of the RP105-MD1 complex. This protein complex was able to block the TLR4 response in whole blood ex-vivo. In vivo gene transfer of plasmid vectors encoding the extracellular part of RP105 and its adaptor protein MD1 were performed to initiate a stable endogenous soluble protein production. Expression of soluble RP105-MD1 resulted in a significant reduction in neointima formation in hypercholesterolemic mice (2500 ± 573 vs.6581 ± 1894 µm(2,p<0.05, whereas expression of the single factors RP105 or MD1 had no effect. CONCLUSION: RP105 is a potent inhibitor of post-interventional neointima formation.

  17. 9 CFR 319.105 - “Ham patties,” “Chopped ham,” “Pressed ham,” “Spiced ham,” and similar products.

    Science.gov (United States)

    2010-01-01

    ... MEAT AND POULTRY PRODUCTS INSPECTION AND VOLUNTARY INSPECTION AND CERTIFICATION DEFINITIONS AND STANDARDS OF IDENTITY OR COMPOSITION Cured Meats, Unsmoked and Smoked § 319.105 “Ham patties,” “Chopped ham... of cured pork product Minimum meat PFF percentage 1 Product name and qualifying statements “Ham...

  18. Articles Treated with Biocidal Products

    OpenAIRE

    Söyleriz, Yüksel

    2015-01-01

    In this study, articles treated with biocidal products have been assessed in the scope of Directive 98/8/EC Concerning the Placing of Biocidal Products on the Market and of Regulation (EU) No 528/2012 concerning the Making Available on the Market and Use of Biocidal Products.

  19. 9 CFR 205.105 - Master list and portion thereof distributed to registrants-format.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Master list and portion thereof distributed to registrants-format. 205.105 Section 205.105 Animals and Animal Products GRAIN INSPECTION... means recording on paper by any technology in a form that can be read by humans without special...

  20. Decommissioning of the 105-F and 105-H fuel storage basin in the 100 Area at the Hanford Site

    International Nuclear Information System (INIS)

    Griffin, P.W.

    1991-09-01

    The US Department of Energy (DOE) owns the eight surplus production reactors at the Hanford Site north of Richland, Washington. The fuel storage basins at the 105-F and 105-H reactors were filled with equipment, associated with the operation of the basins and clean fill in 1970. This was done to stabilize the residual sediment and a few feet of water in the reactors' fuel storage basins. This project investigates the subject basins to locate and remove overlooked fuel elements left in the basins

  1. Dosimetry of 64Cu-DOTA-AE105, a PET tracer for uPAR imaging

    DEFF Research Database (Denmark)

    Persson, Morten; El Ali, Henrik H.; Binderup, Tina

    2014-01-01

    64Cu-DOTA-AE105 is a novel positron emission tomography (PET) tracer specific to the human urokinase-type plasminogen activator receptor (uPAR). In preparation of using this tracer in humans, as a new promising method to distinguish between indolent and aggressive cancers, we have performed PET...... studies in mice to evaluate the in vivo biodistribution and estimate human dosimetry of 64Cu-DOTA-AE105. MethodsFive mice received iv tail injection of 64Cu-DOTA-AE105 and were PET/CT scanned 1, 4.5 and 22h post injection. Volume-of-interest (VOI) were manually drawn on the following organs: heart, lung......Favorable dosimetry estimates together with previously reported uPAR PET data fully support human testing of 64Cu-DOTA-AE105....

  2. Experimental tests of the gravitational inverse-square law for mass separations from 2 to 105 cm

    International Nuclear Information System (INIS)

    Hoskins, J.K.; Newman, R.D.; Spero, R.; Schultz, J.

    1985-01-01

    We report two experiments which test the inverse-square distance dependence of the Newtonian gravitational force law. One experiment uses a torsion balance consisting of a 60-cm-long copper bar suspended at its midpoint by a tungsten wire, to compare the torque produced by copper masses 105 cm from the balance axis with the torque produced by a copper mass 5 cm from the side of the balance bar, near its end. Defining R/sub expt/ to be the measured ratio of the torques due to the masses at 105 cm and 5 cm, and R/sub Newton/ to be the corresponding ratio computed assuming an inverse-square force law, we find deltaequivalent(R/sub expt//R/sub Newton/-1) = (1.2 +- 7) x 10 -4 . Assuming a force deviating from an inverse-square distance dependence by a factor [1+epsilon lnr(cm)], this result implies epsilon = (0.5 +- 2.7) x 10 -4 . An earlier experiment, which has been reported previously, is described here in detail. This experiment tested the inverse-square law over a distance range of approximately 2 to 5 cm, by probing the gravitational field inside a steel mass tube using a copper test mass suspended from the end of a torsion balance bar. This experiment yielded a value for the parameter epsilon defined above: epsilon = (1 +- 7) x 10 -5 . The results of both of these experiments are in good agreement with the Newton- ian prediction. Limits on the strength and range of a Yukawa potential term superimposed on the Newtonian gravitational potential are discussed

  3. Corrective Action Investigation Plan for Corrective Action Unit 105: Area 2 Yucca Flat Atmospheric Test Sites Nevada National Security Site, Nevada, Revision 0

    Energy Technology Data Exchange (ETDEWEB)

    Patrick Matthews

    2012-09-01

    Corrective Action Unit (CAU) 105 is located in Area 2 of the Nevada National Security Site, which is approximately 65 miles northwest of Las Vegas, Nevada. CAU 105 is a geographical grouping of sites where there has been a suspected release of contamination associated with atmospheric nuclear testing. This document describes the planned investigation of CAU 105, which comprises the following corrective action sites (CASs): • 02-23-04, Atmospheric Test Site - Whitney • 02-23-05, Atmospheric Test Site T-2A • 02-23-06, Atmospheric Test Site T-2B • 02-23-08, Atmospheric Test Site T-2 • 02-23-09, Atmospheric Test Site - Turk These sites are being investigated because existing information on the nature and extent of potential contamination is insufficient to evaluate and recommend corrective action alternatives (CAAs). Additional information will be obtained by conducting a corrective action investigation before evaluating CAAs and selecting the appropriate corrective action for each CAS. The results of the field investigation will support a defensible evaluation of viable CAAs that will be presented in the Corrective Action Decision Document. The sites will be investigated based on the data quality objectives (DQOs) developed on April 30, 2012, by representatives of the Nevada Division of Environmental Protection and the U.S. Department of Energy (DOE), National Nuclear Security Administration Nevada Site Office. The DQO process was used to identify and define the type, amount, and quality of data needed to develop and evaluate appropriate corrective actions for CAU 105. The site investigation process will also be conducted in accordance with the Soils Activity Quality Assurance Plan, which establishes requirements, technical planning, and general quality practices to be applied to this activity. The potential contamination sources associated with all CAU 105 CASs are from atmospheric nuclear testing activities. The presence and nature of contamination at CAU

  4. 21 CFR 111.105 - What must quality control personnel do?

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false What must quality control personnel do? 111.105..., LABELING, OR HOLDING OPERATIONS FOR DIETARY SUPPLEMENTS Production and Process Control System: Requirements for Quality Control § 111.105 What must quality control personnel do? Quality control personnel must...

  5. 105-DR Large Sodium Fire Facility closure plan. Revision 1

    Energy Technology Data Exchange (ETDEWEB)

    1993-05-01

    The Hanford Site, located northwest of the city of Richland, Washington, houses reactors, chemical-separation systems, and related facilities used for the production of special nuclear materials, and activities associated with nuclear energy development. The 105-DR Large Sodium Fire Facility (LSFF), which was in operation from about 1972 to 1986, was a research laboratory that occupied the former ventilation supply room on the southwest side of the 105-DR Reactor facility. The LSFF was established to provide a means of investigating fire and safety aspects associated with large sodium or other metal alkali fires in the liquid metal fast breeder reactor (LMFBR) facilities. The 105-DR Reactor facility was designed and built in the 1950`s and is located in the 100-D Area of the Hanford Site. The building housed the 105-DR defense reactor, which was shut down in 1964. The LSFF was initially used only for engineering-scale alkali metal reaction studies. In addition, the Fusion Safety Support Studies program sponsored intermediate-size safety reaction tests in the LSFF with lithium and lithium lead compounds. The facility has also been used to store and treat alkali metal waste, therefore the LSFF is subject to the regulatory requirements for the storage and treatment of dangerous waste. Closure will be conducted pursuant to the requirements of the Washington Administrative Code (WAC) 173-303-610. This closure plan presents a description of the facility, the history of waste managed, and the procedures that will be followed to close the LSFF as an Alkali Metal Treatment Facility. No future use of the LSFF is expected.

  6. 47 CFR 65.105 - Discovery.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 3 2010-10-01 2010-10-01 false Discovery. 65.105 Section 65.105... OF RETURN PRESCRIPTION PROCEDURES AND METHODOLOGIES Procedures § 65.105 Discovery. (a) Participants... evidence. (c) Discovery requests pursuant to § 65.105(b), including written interrogatories, shall be filed...

  7. Positron emission tomography imaging of CD105 expression with {sup 89}Zr-Df-TRC105

    Energy Technology Data Exchange (ETDEWEB)

    Hong, Hao; Yang, Yunan [University of Wisconsin - Madison, Department of Radiology, Madison, WI (United States); Severin, Gregory W.; Engle, Jonathan W.; Zhang, Yin; Barnhart, Todd E.; Nickles, Robert J. [University of Wisconsin - Madison, Department of Medical Physics, Madison, WI (United States); Liu, Glenn [University of Wisconsin - Madison, Department of Medicine, Madison, WI (United States); University of Wisconsin Carbone Cancer Center, Madison, WI (United States); Leigh, Bryan R. [TRACON Pharmaceuticals, Inc, San Diego, CA (United States); Cai, Weibo [University of Wisconsin - Madison, Department of Radiology, Madison, WI (United States); University of Wisconsin - Madison, Department of Medical Physics, Madison, WI (United States); University of Wisconsin Carbone Cancer Center, Madison, WI (United States)

    2012-01-15

    High tumor microvessel density correlates with a poor prognosis in multiple solid tumor types. The clinical gold standard for assessing microvessel density is CD105 immunohistochemistry on paraffin-embedded tumor specimens. The goal of this study was to develop an {sup 89}Zr-based PET tracer for noninvasive imaging of CD105 expression. TRC105, a chimeric anti-CD105 monoclonal antibody, was conjugated to p-isothiocyanatobenzyl-desferrioxamine (Df-Bz-NCS) and labeled with {sup 89}Zr. FACS analysis and microscopy studies were performed to compare the CD105 binding affinity of TRC105 and Df-TRC105. PET imaging, biodistribution, blocking, and ex-vivo histology studies were performed on 4T1 murine breast tumor-bearing mice to evaluate the pharmacokinetics and tumor-targeting of {sup 89}Zr-Df-TRC105. Another chimeric antibody, cetuximab, was used as an isotype-matched control. FACS analysis of HUVECs revealed no difference in CD105 binding affinity between TRC105 and Df-TRC105, which was further validated by fluorescence microscopy. {sup 89}Zr labeling was achieved with high yield and specific activity. Serial PET imaging revealed that the 4T1 tumor uptake of {sup 89}Zr-Df-TRC105 was 6.1 {+-} 1.2, 14.3 {+-} 1.2, 12.4 {+-} 1.5, 7.1 {+-} 0.9, and 5.2 {+-} 0.3 %ID/g at 5, 24, 48, 72, and 96 h after injection, respectively (n = 4), higher than all organs starting from 24 h after injection, which provided excellent tumor contrast. Biodistribution data as measured by gamma counting were consistent with the PET findings. Blocking experiments, control studies with {sup 89}Zr-Df-cetuximab, and ex-vivo histology all confirmed the in vivo target specificity of {sup 89}Zr-Df-TRC105. We report here the first successful PET imaging of CD105 expression with {sup 89}Zr as the radiolabel. Rapid, persistent, CD105-specific uptake of {sup 89}Zr-Df-TRC105 in the 4T1 tumor was observed. (orig.)

  8. 40 CFR 432.105 - New source performance standards (NSPS).

    Science.gov (United States)

    2010-07-01

    ... GUIDELINES AND STANDARDS MEAT AND POULTRY PRODUCTS POINT SOURCE CATEGORY Renderers § 432.105 New source... renderer that does not cure cattle hide as part of the plant operations. If a renderer does cure hide, the...

  9. 15 CFR 270.105 - Duties of a Team.

    Science.gov (United States)

    2010-01-01

    ... 15 Commerce and Foreign Trade 1 2010-01-01 2010-01-01 false Duties of a Team. 270.105 Section 270... OF STANDARDS AND TECHNOLOGY, DEPARTMENT OF COMMERCE NATIONAL CONSTRUCTION SAFETY TEAMS NATIONAL CONSTRUCTION SAFETY TEAMS Establishment and Deployment of Teams § 270.105 Duties of a Team. (a) A Team's Lead...

  10. Determination of the microbiological quality and proximate composition of fermented cassava food products sold in Ilorin-west local government area, Nigeria

    Directory of Open Access Journals (Sweden)

    C.O. Adetunji

    2017-12-01

    Full Text Available In the present study, the microbiological safety and the proximate analyses of five urban markets within Ilorin-West Local Government Area, Kwara State, Nigeria were carried out using standard protocols. The bacterial load of fermented staple products from cassava ranged from 0.1 to 10.9×105 CFU/g while the fungi and yeast content ranged from 1.1 to 8.2×105 CFU/g. The isolates of bacteria from all the markets include the following; Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus epidermis, Streptococus faecalis, Lactobacillus species, Acetobacter spp.., Bacillus cereus, Escherichia coli, Bacillus subtilis, Lactobacillus species while the isolated fungi include Fusarium oxysporium, Aspergillus niger, A.flavus, A. fumigatus, Saccharomyces cerevisae, Candida albicans, Penicillum spp., Rhizopus stolonifera, Mucor spp..The results of the proximate composition showed that moisture content of fermented staple products of cassava ranged from 6.21% (garri Ijebu from market A and lebu from market C to 72.25% (fufu from market C while dry matter content ranged between 27.75% (Fufu from market C to 93.79% (garri Ijebu market A and lebu from market C. Ash content ranged from 0.23% (Tapioca from market A to 1.96% (lebu from market A, crude fibre content ranged between 1.13% (Fufu from market C and 5.28% (Abacha from market D, and the carbohydrate content of the fermented staple products from cassava ranged from 18.61% (Fufu from market C to 81.44% (Tapioca from market A. Even though some potential pathogenic bacteria like E.coli and Bacillus were isolated from cassava fermented products, the minimum microbial load obtained could not impose any health risk.

  11. Acceptance testing report of Eductor System to be installed in the 105 K Basins

    International Nuclear Information System (INIS)

    Packer, M.J.

    1996-01-01

    The Spent Nuclear Fuel (SNF) Project Engineering Support group cold-tested the Eductor System a 15 horsepower multi-stage centrifugal pump manufactured by the Grunfos Corporation with the housing manufactured and sold with the pump by the Tri-Nuclear Corporation and a 3-inch diameter water jet eductor manufactured by the Fox Valve Corporation. The Eductor System was tested to gather and document information to optimize sludge retrieval operations for use in the 105 K Basins. The cold-testing took place during February 12 through February 29, 1996 in the 305 Cold Test Facility basin located in the 300 area. The pump, utilized in conjunction with the eductor, makes up the core of the Eductor System. The pumping unit consists of a 15 hp stainless steel multi-stage centrifugal Grunfos pump which is seated in a stainless steel fabricated housing. Two baskets or filter elements make up part of the housing on the suction side of the pump. The pump can be used independent of the housing but the housing has two identified purposes. The first use is to stabilize the centrifugal pump and give the pneumatic valves and pump discharge piping a solid platform so the Eductor System can be more easily mobilized within the basin as one unit. The second use for the housing presents the option to utilize the suction-side filters for capturing larger fuel pieces after the smaller fines have been removed

  12. Optimization and Improvement of Test Processes on a Production Line

    Science.gov (United States)

    Sujová, Erika; Čierna, Helena

    2018-06-01

    The paper deals with increasing processes efficiency at a production line of cylinder heads of engines in a production company operating in the automotive industry. The goal is to achieve improvement and optimization of test processes on a production line. It analyzes options for improving capacity, availability and productivity of processes of an output test by using modern technology available on the market. We have focused on analysis of operation times before and after optimization of test processes at specific production sections. By analyzing measured results we have determined differences in time before and after improvement of the process. We have determined a coefficient of efficiency OEE and by comparing outputs we have confirmed real improvement of the process of the output test of cylinder heads.

  13. Protein engineering of CYP105s for their industrial uses.

    Science.gov (United States)

    Yasuda, Kaori; Sugimoto, Hiroshi; Hayashi, Keiko; Takita, Teisuke; Yasukawa, Kiyoshi; Ohta, Miho; Kamakura, Masaki; Ikushiro, Shinichi; Shiro, Yoshitsugu; Sakaki, Toshiyuki

    2018-01-01

    Cytochrome P450 enzymes belonging to the CYP105 family are predominantly found in bacteria belonging to the phylum Actinobacteria and the order Actinomycetales. In this review, we focused on the protein engineering of P450s belonging to the CYP105 family for industrial use. Two Arg substitutions to Ala of CYP105A1 enhanced its vitamin D 3 25- and 1α-hydroxylation activities by 400 and 100-fold, respectively. The coupling efficiency between product formation and NADPH oxidation was largely improved by the R84A mutation. The quintuple mutant Q87W/T115A/H132L/R194W/G294D of CYP105AB3 showed a 20-fold higher activity than the wild-type enzyme. Amino acids at positions 87 and 191 were located at the substrate entrance channel, and that at position 294 was located close to the heme group. Semi-rational engineering of CYP105A3 selected the best performing mutant, T85F/T119S/V194N/N363Y, for producing pravastatin. The T119S and N363Y mutations synergistically had remarkable effects on the interaction between CYP105A3 and putidaredoxin. Although wild-type CYP105AS1 hydroxylated compactin to 6-epi-pravastatin, the quintuple mutant I95T/Q127R/A180V/L236I/A265N converted almost all compactin to pravastatin. Five amino acid substitutions by two rounds of mutagenesis almost completely changed the stereo-selectivity of CYP105AS1. These results strongly suggest that the protein engineering of CYP105 enzymes greatly increase their industrial utility. This article is part of a Special Issue entitled: Cytochrome P450 biodiversity and biotechnology, edited by Erika Plettner, Gianfranco Gilardi, Luet Wong, Vlada Urlacher, Jared Goldstone. Copyright © 2017 Elsevier B.V. All rights reserved.

  14. 28 CFR 105.22 - Definitions.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Definitions. 105.22 Section 105.22... Security Officer Employment § 105.22 Definitions. As used in this subpart: (a) Authorized employer means... equipment); protect against fire, theft, misappropriation, vandalism, violence, terrorism, and other illegal...

  15. 32 CFR 10.5 - Construction.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Construction. 10.5 Section 10.5 National Defense Department of Defense OFFICE OF THE SECRETARY OF DEFENSE MILITARY COMMISSIONS MILITARY COMMISSION INSTRUCTIONS § 10.5 Construction. Military Commission Instructions shall be construed in a manner consistent...

  16. Antimicrobials Products Tested or Pending Testing

    Science.gov (United States)

    The agency has completed testing of the majority of registered hospital disinfectants and tuberculocide products. The list of products can assist users in making informed choices regarding infection control in their facilities.

  17. 7 CFR 3018.105 - Definitions.

    Science.gov (United States)

    2010-01-01

    ... services in the private sector. (o) Recipient includes all contractors, subcontractors at any tier, and... 7 Agriculture 15 2010-01-01 2010-01-01 false Definitions. 3018.105 Section 3018.105 Agriculture... AGRICULTURE NEW RESTRICTIONS ON LOBBYING General § 3018.105 Definitions. For purposes of this part: (a) Agency...

  18. 13 CFR 500.105 - Staff.

    Science.gov (United States)

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Staff. 500.105 Section 500.105... LOAN PROGRAM Board Procedures § 500.105 Staff. (a) Executive Director. The Executive Director of the... direction with respect to the administration of the Board's actions, directs the activities of the staff...

  19. 13 CFR 400.105 - Staff.

    Science.gov (United States)

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Staff. 400.105 Section 400.105... Board Procedures § 400.105 Staff. (a) Executive Director. The Executive Director of the Board advises... with respect to the administration of the Board's actions, directs the activities of the staff, and...

  20. 45 CFR 1230.105 - Definitions.

    Science.gov (United States)

    2010-10-01

    ... services in the private sector. (o) Recipient includes all contractors, subcontractors at any tier, and... 45 Public Welfare 4 2010-10-01 2010-10-01 false Definitions. 1230.105 Section 1230.105 Public... NEW RESTRICTIONS ON LOBBYING General § 1230.105 Definitions. For purposes of this part: (a) Agency, as...

  1. 24 CFR 51.105 - Exceptions.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Exceptions. 51.105 Section 51.105... ENVIRONMENTAL CRITERIA AND STANDARDS Noise Abatement and Control § 51.105 Exceptions. (a) Flexibility for non... acceptability standard of 65 decibels, the Acceptable Zone may be shifted to Ldn 70 on a case-by-case basis if...

  2. 32 CFR 28.105 - Definitions.

    Science.gov (United States)

    2010-07-01

    ... services in the private sector. (o) Recipient includes all contractors, subcontractors at any tier, and... 32 National Defense 1 2010-07-01 2010-07-01 false Definitions. 28.105 Section 28.105 National... RESTRICTIONS ON LOBBYING General § 28.105 Definitions. For purposes of this part: (a) Agency, as defined in 5 U...

  3. 40 CFR 34.105 - Definitions.

    Science.gov (United States)

    2010-07-01

    ... services in the private sector. (o) Recipient includes all contractors, subcontractors at any tier, and... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Definitions. 34.105 Section 34.105... RESTRICTIONS ON LOBBYING General § 34.105 Definitions. For purposes of this part: (a) Agency, as defined in 5 U...

  4. 29 CFR 93.105 - Definitions.

    Science.gov (United States)

    2010-07-01

    ... services in the private sector. (o) Recipient includes all contractors, subcontractors at any tier, and... 29 Labor 1 2010-07-01 2010-07-01 true Definitions. 93.105 Section 93.105 Labor Office of the Secretary of Labor NEW RESTRICTIONS ON LOBBYING General § 93.105 Definitions. For purposes of this part: (a...

  5. 46 CFR 57.06-2 - Production test plate interval of testing.

    Science.gov (United States)

    2010-10-01

    ... WELDING AND BRAZING Production Tests § 57.06-2 Production test plate interval of testing. (a) At least one... 46 Shipping 2 2010-10-01 2010-10-01 false Production test plate interval of testing. 57.06-2... follows: (1) When the extent of welding on a single vessel exceeds 50 lineal feet of either or both...

  6. 29 CFR 99.105 - Definitions.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 1 2010-07-01 2010-07-01 true Definitions. 99.105 Section 99.105 Labor Office of the Secretary of Labor AUDITS OF STATES, LOCAL GOVERNMENTS, AND NON-PROFIT ORGANIZATIONS General § 99.105 Definitions. Audit finding means deficiencies which the auditor is required by § 99.510(a) to report in the...

  7. 24 CFR 87.105 - Definitions.

    Science.gov (United States)

    2010-04-01

    ... services in the private sector. (o) Recipient includes all contractors, subcontractors at any tier, and... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Definitions. 87.105 Section 87.105... RESTRICTIONS ON LOBBYING General § 87.105 Definitions. For purposes of this part: (a) Agency, as defined in 5 U...

  8. 12 CFR 411.105 - Definitions.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 4 2010-01-01 2010-01-01 false Definitions. 411.105 Section 411.105 Banks and Banking EXPORT-IMPORT BANK OF THE UNITED STATES NEW RESTRICTIONS ON LOBBYING General § 411.105 Definitions. For purposes of this part: (a) Agency, as defined in 5 U.S.C. 552(f), includes Federal executive...

  9. Cigarette Smoking Is Associated with a Lower Concentration of CD105+ Bone Marrow Progenitor Cells

    Directory of Open Access Journals (Sweden)

    Shaul Beyth

    2015-01-01

    Full Text Available Cigarette smoking is associated with musculoskeletal degenerative disorders, delayed fracture healing, and nonunion. Bone marrow progenitor cells (BMPCs, known to express CD105, are important in local trophic and immunomodulatory activity and central to musculoskeletal healing/regeneration. We hypothesized that smoking is associated with lower levels of BMPC. Iliac bone marrow samples were collected from individuals aged 18–65 years during the first steps of pelvic surgery, under IRB approval with informed consent. Patients with active infectious or neoplastic disease, a history of cytotoxic or radiation therapy, primary or secondary metabolic bone disease, or bone marrow dysfunction were excluded. Separation process purity and the number of BMPCs recovered were assessed with FACS. BMPC populations in self-reported smokers and nonsmokers were compared using the two-tailed t-test. 13 smokers and 13 nonsmokers of comparable age and gender were included. The average concentration of BMPCs was 3.52 × 105/mL ± 2.45 × 105/mL for nonsmokers versus 1.31 × 105/mL ± 1.61 × 105/mL for smokers (t= 3.2, P=0.004. This suggests that cigarette smoking is linked to a significant decrease in the concentration of BMPCs, which may contribute to the reduced regenerative capacity of smokers, with implications for musculoskeletal maintenance and repair.

  10. Corrective Action Decision Document/Closure Report for Corrective Action Unit 105: Area 2 Yucca Flat Atmospheric Test Sites, Nevada National Security Site, Nevada, Revision 1

    Energy Technology Data Exchange (ETDEWEB)

    Matthews, Patrick

    2014-01-01

    The purpose of this Corrective Action Decision Document/Closure Report is to provide justification and documentation supporting the recommendation that no further corrective action is needed for CAU 105 based on the implementation of the corrective actions. Corrective action investigation (CAI) activities were performed from October 22, 2012, through May 23, 2013, as set forth in the Corrective Action Investigation Plan for Corrective Action Unit 105: Area 2 Yucca Flat Atmospheric Test Sites; and in accordance with the Soils Activity Quality Assurance Plan, which establishes requirements, technical planning, and general quality practices.

  11. 7 CFR 927.105 - Communications.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Communications. 927.105 Section 927.105 Agriculture Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (Marketing Agreements... Rules and Regulations Communications § 927.105 Communications. Unless otherwise prescribed in this...

  12. 20 CFR 416.105 - Administration.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Administration. 416.105 Section 416.105 Employees' Benefits SOCIAL SECURITY ADMINISTRATION SUPPLEMENTAL SECURITY INCOME FOR THE AGED, BLIND, AND DISABLED Introduction, General Provisions and Definitions § 416.105 Administration. The Supplemental...

  13. 49 CFR 234.105 - Activation failure.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Activation failure. 234.105 Section 234.105... of Warning System Malfunction § 234.105 Activation failure. Upon receipt of a credible report of warning system malfunction involving an activation failure, a railroad having maintenance responsibility...

  14. 20 CFR 438.105 - Definitions.

    Science.gov (United States)

    2010-04-01

    ... private sector. Recipient includes all contractors, subcontractors at any tier, and subgrantees at any... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Definitions. 438.105 Section 438.105 Employees' Benefits SOCIAL SECURITY ADMINISTRATION RESTRICTIONS ON LOBBYING General § 438.105 Definitions...

  15. 13 CFR 101.105 - Who may use SBA's official seal and for what purpose?

    Science.gov (United States)

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Who may use SBA's official seal and for what purpose? 101.105 Section 101.105 Business Credit and Assistance SMALL BUSINESS... be used in any manner which implies SBA endorsement of commercial products or services or of the user...

  16. 49 CFR 1572.105 - Immigration status.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Immigration status. 1572.105 Section 1572.105... ASSESSMENTS Standards for Security Threat Assessments § 1572.105 Immigration status. (a) An individual... to an order of removal under the immigration laws of the United States is not eligible to apply for a...

  17. 34 CFR 105.30 - Employment.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Employment. 105.30 Section 105.30 Education Regulations... DEPARTMENT OF EDUCATION § 105.30 Employment. No qualified individual with handicaps shall, on the basis of handicap, be subjected to discrimination in employment under any program or activity conducted by the...

  18. 22 CFR 311.105 - Definitions.

    Science.gov (United States)

    2010-04-01

    ... services in the private sector. (o) Recipient includes all contractors, subcontractors at any tier, and... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Definitions. 311.105 Section 311.105 Foreign Relations PEACE CORPS NEW RESTRICTIONS ON LOBBYING General § 311.105 Definitions. For purposes of this part...

  19. 41 CFR 105-68.995 - Principal.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Principal. 105-68.995 Section 105-68.995 Public Contracts and Property Management Federal Property Management Regulations System...-GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) Definitions § 105-68.995 Principal. Principal means— (a...

  20. Positron emission tomography imaging of CD105 expression in a rat myocardial infarction model with (64)Cu-NOTA-TRC105.

    Science.gov (United States)

    Orbay, Hakan; Zhang, Yin; Valdovinos, Hector F; Song, Guoqing; Hernandez, Reinier; Theuer, Charles P; Hacker, Timothy A; Nickles, Robert J; Cai, Weibo

    2013-01-01

    Biological changes following myocardial infarction (MI) lead to increased secretion of angiogenic factors that subsequently stimulate the formation of new blood vessels as a compensatory mechanism to reverse ischemia. The goal of this study was to assess the role of CD105 expression during MI-induced angiogenesis by positron emission tomography (PET) imaging using (64)Cu-labeled TRC105, an anti-CD105 monoclonal antibody. MI was induced by ligation of the left anterior descending (LAD) artery in female rats. Echocardiography and (18)F-fluoro-2-deoxy-D-glucose ((18)F-FDG) PET scans were performed on post-operative day 3 to confirm the presence of MI in the infarct group and intact heart in the sham group, respectively. Ischemia-induced angiogenesis was non-invasively monitored with (64)Cu-NOTA-TRC105 (an extensively validated PET tracer in our previous studies) PET on post-operative days 3, 10, and 17. Tracer uptake in the infarct zone was highest on day 3 following MI, which was significantly higher than that in the sham group (1.41 ± 0.45 %ID/g vs 0.57 ± 0.07 %ID/g; n=3, p<0.05). Subsequently, tracer uptake in the infarct zone decreased over time to the background level on day 17, whereas tracer uptake in the heart of sham rats remained low at all time points examined. Histopathology documented increased CD105 expression following MI, which corroborated in vivo findings. This study indicated that PET imaging of CD105 can be a useful tool for MI-related research, which can potentially improve MI patient management in the future upon clinical translation of the optimized PET tracers.

  1. 47 CFR 78.105 - Antenna systems.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 4 2010-10-01 2010-10-01 false Antenna systems. 78.105 Section 78.105... SERVICE Technical Regulations § 78.105 Antenna systems. (a) For fixed stations operating in the 12.7-13.2... planes. (2) New periscope antenna systems will be authorized upon a certification that the radiation, in...

  2. 41 CFR 105-1.110 - Deviation.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Deviation. 105-1.110 Section 105-1.110 Public Contracts and Property Management Federal Property Management Regulations System (Continued) GENERAL SERVICES ADMINISTRATION 1-INTRODUCTION 1.1-Regulations System § 105-1.110 Deviation. (a...

  3. 41 CFR 105-1.150 - Citation.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Citation. 105-1.150 Section 105-1.150 Public Contracts and Property Management Federal Property Management Regulations System (Continued) GENERAL SERVICES ADMINISTRATION 1-INTRODUCTION 1.1-Regulations System § 105-1.150 Citation. (a...

  4. 34 CFR 300.105 - Assistive technology.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 2 2010-07-01 2010-07-01 false Assistive technology. 300.105 Section 300.105 Education... DISABILITIES State Eligibility Other Fape Requirements § 300.105 Assistive technology. (a) Each public agency must ensure that assistive technology devices or assistive technology services, or both, as those terms...

  5. 46 CFR 133.105 - Survival craft.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Survival craft. 133.105 Section 133.105 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OFFSHORE SUPPLY VESSELS LIFESAVING SYSTEMS Requirements for All OSVs § 133.105 Survival craft. (a) Each survival craft must be approved and equipped as...

  6. 34 CFR 105.10 - Self-evaluation.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Self-evaluation. 105.10 Section 105.10 Education... DEPARTMENT OF EDUCATION § 105.10 Self-evaluation. (a) The Department shall, within one year of the effective... organizations representing individuals with handicaps to participate in the self-evaluation process by...

  7. A/T test system for production line; Seisan line yo A/T test system

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-03-10

    This paper introduces an A/T test system for production line made by Meidensha, Inc. Rates and technology of mounting auto-transmissions (A/T) in recent automobiles are improving year after year. A/T production line testers were fabricated and supplied, including those for European countries. This system has the following features: the system employs low inertia AC motor, and is capable of performing tests in close conditions to actual cars; an insulated gate bipolar transistor (IGBT) inverter was employed to achieve control accuracy improvement and noise reduction; high-velocity transient measurement is possible by using a computer system based on the WindowsNT; a solenoid current slant control was employed to respond to electronically controlled A/T; and noise and vibration shift feeling instrumentation can also be used on option. Number of supply is four sets of front engine/front wheel drive (FF) car A/T testers for overseas countries, and two sets of FF A/T tests for use in Japan. (NEDO)

  8. Eleven new heaviest isotopes of elements Z=105 to Z=117 identified among the products of 249Bk+48Ca reactions

    International Nuclear Information System (INIS)

    Oganessian, Yu. Ts.; Abdullin, F. Sh.; Dmitriev, S. N.; Itkis, M. G.; Lobanov, Yu. V.; Mezentsev, A. N.; Polyakov, A. N.; Sagaidak, R. N.; Shirokovsky, I. V.; Subbotin, V. G.; Sukhov, A. M.; Tsyganov, Yu. S.; Utyonkov, V. K.; Voinov, A. A.; Vostokin, G. K.; Bailey, P. D.; Benker, D. E.; Ezold, J. G.; Porter, C. E.; Riley, F. D.

    2011-01-01

    The heaviest isotopes of elements Z=117 to Z=105, 294 117, 293 117, 290 115, 289 115, 286 113, 285 113, 282 Rg, 281 Rg, 278 Mt, 274 Bh, and 270 Db, were identified by means of the Dubna gas-filled recoil separator among the products of the 249 Bk + 48 Ca reaction. The details of the observed six decay chains, indicating the production and decay of isotopes 293 117 and 294 117, are presented and discussed. The decay energies and resulting half-lives of these new nuclei show a strong rise of stability with increasing neutron number, validating the concept of the island of enhanced stability for superheavy nuclei [Oganessian et al., Phys. Rev. Lett. 104, 142502 (2010)].

  9. 21 CFR 201.105 - Veterinary drugs.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false Veterinary drugs. 201.105 Section 201.105 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) DRUGS: GENERAL LABELING Exemptions From Adequate Directions for Use § 201.105 Veterinary drugs. A drug subject to the...

  10. 10 CFR 431.105 - Materials incorporated by reference.

    Science.gov (United States)

    2010-01-01

    ..._regulations/ibr_locations.html. (ii) U.S. Department of Energy, Office of Energy Efficiency and Renewable Energy, Hearings and Dockets, “Test Procedures and Efficiency Standards for Commercial Water Heaters, Hot....105 Energy DEPARTMENT OF ENERGY ENERGY CONSERVATION ENERGY EFFICIENCY PROGRAM FOR CERTAIN COMMERCIAL...

  11. 40 CFR 65.105 - Leak repair.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 15 2010-07-01 2010-07-01 false Leak repair. 65.105 Section 65.105... FEDERAL AIR RULE Equipment Leaks § 65.105 Leak repair. (a) Leak repair schedule. The owner or operator shall repair each leak detected as soon as practical but not later than 15 calendar days after it is...

  12. Preclinical and first-in-human evaluation of PRX-105, a PEGylated, plant-derived, recombinant human acetylcholinesterase-R

    International Nuclear Information System (INIS)

    Atsmon, Jacob; Brill-Almon, Einat; Nadri-Shay, Carmit; Chertkoff, Raul; Alon, Sari; Shaikevich, Dimitri; Volokhov, Inna; Haim, Kirsten Y.; Bartfeld, Daniel; Shulman, Avidor; Ruderfer, Ilya; Ben-Moshe, Tehila; Shilovitzky, Orit; Soreq, Hermona; Shaaltiel, Yoseph

    2015-01-01

    PRX-105 is a plant-derived recombinant version of the human ‘read-through’ acetylcholinesterase splice variant (AChE-R). Its active site structure is similar to that of the synaptic variant, and it displays the same affinity towards organophosphorus (OP) compounds. As such, PRX-105 may serve as a bio-scavenger for OP pesticides and chemical warfare agents. To assess its potential use in prophylaxis and treatment of OP poisoning we conducted several preliminary tests, reported in this paper. Intravenous (IV) PRX-105 was administered to mice either before or after exposure to an OP toxin. All mice who received an IV dose of 50 nmol/kg PRX-105, 2 min before being exposed to 1.33 × LD 50 and 1.5 × LD 50 of toxin and 10 min after exposure to 1.5 × LD 50 survived. The pharmacokinetic and toxicity profiles of PRX-105 were evaluated in mice and mini-pigs. Following single and multiple IV doses (50 to 200 mg/kg) no deaths occurred and no significant laboratory and histopathological changes were observed. The overall elimination half-life (t ½ ) in mice was 994 (± 173) min. Additionally, a first-in-human study, to assess the safety, tolerability and pharmacokinetics of the compound, was conducted in healthy volunteers. The t ½ in humans was substantially longer than in mice (average 26.7 h). Despite the small number of animals and human subjects who were assessed, the fact that PRX-105 exerts a protective and therapeutic effect following exposure to lethal doses of OP, its favorable safety profile and its relatively long half-life, renders it a promising candidate for treatment and prophylaxis against OP poisoning and warrants further investigation. - Highlights: • PRX-105 is a PEGylated plant-derived recombinant human acetylcholinesterase-R. • PRX-105 is a promising bio-scavenger for organophosphorous toxins at lethal doses. • PRX-105 was shown to protect animals both prophylactically and post-poisoning. • First-in-human study exhibited its safety

  13. Preclinical and first-in-human evaluation of PRX-105, a PEGylated, plant-derived, recombinant human acetylcholinesterase-R

    Energy Technology Data Exchange (ETDEWEB)

    Atsmon, Jacob [Clinical Research Center, Tel Aviv Sourasky Medical Center, Tel Aviv (Israel); Sackler Faculty of Medicine, Tel Aviv University (Israel); Brill-Almon, Einat; Nadri-Shay, Carmit; Chertkoff, Raul; Alon, Sari [Protalix Biotherapeutics, Science Park, Carmiel (Israel); Shaikevich, Dimitri; Volokhov, Inna; Haim, Kirsten Y. [Clinical Research Center, Tel Aviv Sourasky Medical Center, Tel Aviv (Israel); Sackler Faculty of Medicine, Tel Aviv University (Israel); Bartfeld, Daniel [Protalix Biotherapeutics, Science Park, Carmiel (Israel); Shulman, Avidor, E-mail: avidors@protalix.com [Protalix Biotherapeutics, Science Park, Carmiel (Israel); Ruderfer, Ilya; Ben-Moshe, Tehila; Shilovitzky, Orit [Protalix Biotherapeutics, Science Park, Carmiel (Israel); Soreq, Hermona [Department of Biological Chemistry, Institute of Life Sciences, The Hebrew University of Jerusalem (Israel); Shaaltiel, Yoseph [Protalix Biotherapeutics, Science Park, Carmiel (Israel)

    2015-09-15

    PRX-105 is a plant-derived recombinant version of the human ‘read-through’ acetylcholinesterase splice variant (AChE-R). Its active site structure is similar to that of the synaptic variant, and it displays the same affinity towards organophosphorus (OP) compounds. As such, PRX-105 may serve as a bio-scavenger for OP pesticides and chemical warfare agents. To assess its potential use in prophylaxis and treatment of OP poisoning we conducted several preliminary tests, reported in this paper. Intravenous (IV) PRX-105 was administered to mice either before or after exposure to an OP toxin. All mice who received an IV dose of 50 nmol/kg PRX-105, 2 min before being exposed to 1.33 × LD{sub 50} and 1.5 × LD{sub 50} of toxin and 10 min after exposure to 1.5 × LD{sub 50} survived. The pharmacokinetic and toxicity profiles of PRX-105 were evaluated in mice and mini-pigs. Following single and multiple IV doses (50 to 200 mg/kg) no deaths occurred and no significant laboratory and histopathological changes were observed. The overall elimination half-life (t{sub ½}) in mice was 994 (± 173) min. Additionally, a first-in-human study, to assess the safety, tolerability and pharmacokinetics of the compound, was conducted in healthy volunteers. The t{sub ½} in humans was substantially longer than in mice (average 26.7 h). Despite the small number of animals and human subjects who were assessed, the fact that PRX-105 exerts a protective and therapeutic effect following exposure to lethal doses of OP, its favorable safety profile and its relatively long half-life, renders it a promising candidate for treatment and prophylaxis against OP poisoning and warrants further investigation. - Highlights: • PRX-105 is a PEGylated plant-derived recombinant human acetylcholinesterase-R. • PRX-105 is a promising bio-scavenger for organophosphorous toxins at lethal doses. • PRX-105 was shown to protect animals both prophylactically and post-poisoning. • First-in-human study

  14. Tank 241-A-105 evaporation estimate, 1970 through 1978

    International Nuclear Information System (INIS)

    Allen, G.K.

    1991-09-01

    Tank 241-A-105 was subjected to a severe steam explosion in January 1965 that caused the metal liner on the bottom to bulge upward approximately 8 feet above its concrete foundation. Shortly after this event, radiation was detected in drywells around the tank and it was declared a leaker. Sluicing operations to remove material from the tank began in August 1968 and continued through August 1970. After sluicing was completed, a significant amount of heat generating material still remained in the tank. To keep tank temperatures below operating limits, the water level in the tank was maintained at an approximate depth of 1.5 feet. This practice was continued until January 1979 when it was believed that the contents had decayed sufficiently to discontinue the water addition and put the tank on a portable exhauster system. Recent concern has focused on what portion of this cooling water added to Tank 241-A-105 actually evaporated and how much leaked into the soil during the nine year time period. This report presents the results of a study that estimates the amount of water evaporated from Tank 241-A-105 between 1970 and 1979. The problem was completed in two parts. The first part involved development of a three dimensional heat transfer model which was used to establish the tank heat load. The results of this model were validated against thermocouple data from Tank 241-A-105. The heat removed from the tank by the ventilation air was then used as input to a second computer code, which calculated the water evaporation. Based upon these two models, the amount of water evaporated from Tank 241-A-105, between 1970 and 1979, was between 378,000 and 410,000 gallons. 9 refs., 17 figs., 7 tabs

  15. Tobacco and Nicotine Product Testing

    Science.gov (United States)

    Biener, Lois; Leischow, Scott J.; Zeller, Mitch R.

    2012-01-01

    Introduction: Tobacco product testing is a critical component of the Family Smoking Prevention and Tobacco Control Act (FSPTCA), which grants the Food and Drug Administration the authority to regulate tobacco products. The availability of methods and measures that can provide accurate data on the relative health risks across types of tobacco products, brands, and subbrands of tobacco products on the validity of any health claims associated with a product, and on how consumers perceive information on products toxicity or risks is crucial for making decisions on the product's potential impact on public health. These tools are also necessary for making assessments of the impact of new indications for medicinal products (other than cessation) but more importantly of tobacco products that may in the future be marketed as cessation tools. Objective: To identify research opportunities to develop empirically based and comprehensive methods and measures for testing tobacco and other nicotine-containing products so that the best science is available when decisions are made about products or policies. Methods: Literature was reviewed to address sections of the FSPTCA relevant to tobacco product evaluation; research questions were generated and then reviewed by a committee of research experts. Results: A research agenda was developed for tobacco product evaluation in the general areas of toxicity and health risks, abuse liability, consumer perception, and population effects. Conclusion: A cohesive, systematic, and comprehensive assessment of tobacco products is important and will require building consensus and addressing some crucial research questions. PMID:21460383

  16. Nuclear-physical properties of 105,106m,110mAg

    International Nuclear Information System (INIS)

    Popov, Yu. S.; Zakharova, L. V.; Sadulin, V. V.; Andreev, O. I.; Pakhomov, A. N.

    2005-01-01

    The nuclear-physical properties of the nuclides 105,106m,110m Ag, which are concomitant nuclides in reactor production of 103 Pd and 109 Cd used in metrology of ionizing radiations and in nuclear medicine, were studied. The following quantities were determined by semiconductor X-ray and γ-ray spectrometry: the parameter K α /K β of X-ray K radiation accompanying the decay of 110m Ag and the intensities of γ-ray quanta with the energies of 280 and 345 keV ( 105 Ag); 430, 451, and 512 keV ( 106m Ag); 658, 764, 885, 938, and 1384 keV ( 110m Ag). The half-lives determined using the above γ-ray lines are as follows: T 1/2 ( 105 Ag) = 41.2 ± 0.1 days; T 1/2 ( 106m Ag) = 8.30 ± 0.07 days. The errors are given for 95% confidence level [ru

  17. The SEPS1 G-105A polymorphism is associated with risk of spontaneous preterm birth in a Chinese population.

    Directory of Open Access Journals (Sweden)

    Yan Wang

    Full Text Available Inflammation plays an important role in the etiology and pathophysiology of spontaneous preterm birth (SPTB, and selenoprotein S (SEPS1 is involved in regulating the inflammatory response. Recently the G-105A promoter polymorphism in SEPS1 was shown to increase pro-inflammatory cytokine expression. We examined whether this functional polymorphism was related to the risk of SPTB in a Chinese population. We also examined the impact of premature rupture of membranes (PROM on susceptibility to SPTB. The SEPS1 G-105A polymorphism was genotyped in 569 preterm singleton neonates and 673 term neonates by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP analysis. χ (2 tests and logistic regression analyses were used to calculate the odds ratios (ORs and 95% confidence intervals (95% CIs. We observed that, compared with the GG genotype, -105A positive genotypes (GA + AA genotypes were associated with significantly increased susceptibility to SPTB (adjusted OR, 1.87; 95% CI, 1.36-2.57; P<0.001. The -105A positive genotypes were also significantly associated with increased susceptibility to SPTB, both in the patients with PROM (adjusted OR, 2.65; 95% CI, 1.73-4.03; P<0.001 and in those without PROM (adjusted OR, 1.56; 95% CI, 1.09-2.24; P = 0.015. The -105A positive genotypes were also significantly associated with increased susceptibility to SPTB between extremely preterm neonates and controls (adjusted OR, 4.46; 95% CI, 1.86-10.73; P = 0.002 and between moderately preterm neonates and controls (adjusted OR, 1.76; 95% CI, 1.25-2.47; P = 0.001. Our findings suggest that the SEPS1 G-105A polymorphism contributes to the risk of developing SPTB in a Chinese population.

  18. 105 K East isolation barrier acceptance analysis report

    International Nuclear Information System (INIS)

    McCracken, K.J.; Irwin, J.J.

    1995-01-01

    The objective of this document is to report and interpret the findings of the isolation barrier acceptance tests performed in 105KE/100K. The tests were performed in accordance with the test plan (McCracken 1995c) and acceptance test procedure (McCracken 1995a). The test report (McCracken 1995b) contains the test data. This document compares the test data (McCracken 1995b) against the criteria (McCracken 1995a, c). A discussion of the leak rate analytical characterization (Irwin 1995) describes how the flow characteristics and the flow rate will be determined using the test data from the test report (McCracken 1995b). The barriers must adequately control the leakage from the main basin to the discharge chute to less than the 1,500 gph (5,680 lph) Safety Analysis Report (SAR 1994) limit

  19. The use of sanitation products in milk and cheese production

    Directory of Open Access Journals (Sweden)

    Samir Kalit

    2001-06-01

    Full Text Available Considering hygienic conditions in cheese production the aim of thispaper was to investigate the influence of using some sanitation* products in milk and cheese production on family farms. This investigation was a part of the project “Improving the quality of Tounj cheese produced on family farms”. By use of the sanitation products, during milk production, significant (P<0.01 decrease of geometrical mean of total bacterial count from 3.54 x 105 to 8 x 103 in mL of milk, as well as significant (P<0.01 decrease of geometric mean of somatic cell count from 3.1 x 105 to 2.4 x 105 in mL of milk was observed. The ratio of hygienically unacceptable cheeses, according to the Regulations of microbial standards for foods (NN 46/94., significantly (P<0.01 decreased as well. Because of the new requests and standards, the sanitation products are more in use in both milk and cheese production on family farms. Investigated sanitation products were suitable for use in milk and Tounj cheese production.

  20. 41 CFR 101-4.105 - Definitions.

    Science.gov (United States)

    2010-07-01

    ... PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Introduction § 101-4.105 Definitions. As used... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Definitions. 101-4.105 Section 101-4.105 Public Contracts and Property Management Federal Property Management Regulations System...

  1. 41 CFR 105-1.106 - Applicability.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Applicability. 105-1.106 Section 105-1.106 Public Contracts and Property Management Federal Property Management Regulations System (Continued) GENERAL SERVICES ADMINISTRATION 1-INTRODUCTION 1.1-Regulations System § 105-1.106 Applicability...

  2. 41 CFR 105-1.109 - Numbering.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Numbering. 105-1.109 Section 105-1.109 Public Contracts and Property Management Federal Property Management Regulations System (Continued) GENERAL SERVICES ADMINISTRATION 1-INTRODUCTION 1.1-Regulations System § 105-1.109 Numbering. ...

  3. 29 CFR 1926.105 - Safety nets.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 8 2010-07-01 2010-07-01 false Safety nets. 1926.105 Section 1926.105 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR (CONTINUED) SAFETY AND HEALTH REGULATIONS FOR CONSTRUCTION Personal Protective and Life Saving Equipment § 1926.105...

  4. 41 CFR 105-74.665 - State.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false State. 105-74.665 Section 105-74.665 Public Contracts and Property Management Federal Property Management Regulations System...-GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 105-74.665 State. State...

  5. 41 CFR 105-74.630 - Debarment.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Debarment. 105-74.630 Section 105-74.630 Public Contracts and Property Management Federal Property Management Regulations System...-GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 105-74.630 Debarment...

  6. 41 CFR 105-74.605 - Award.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Award. 105-74.605 Section 105-74.605 Public Contracts and Property Management Federal Property Management Regulations System...-GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 105-74.605 Award. Award...

  7. 41 CFR 105-74.660 - Recipient.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Recipient. 105-74.660 Section 105-74.660 Public Contracts and Property Management Federal Property Management Regulations System...-GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 105-74.660 Recipient...

  8. 41 CFR 105-74.670 - Suspension.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Suspension. 105-74.670 Section 105-74.670 Public Contracts and Property Management Federal Property Management Regulations System...-GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 105-74.670 Suspension...

  9. 41 CFR 105-74.615 - Conviction.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Conviction. 105-74.615 Section 105-74.615 Public Contracts and Property Management Federal Property Management Regulations System...-GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 105-74.615 Conviction...

  10. 41 CFR 105-74.655 - Individual.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Individual. 105-74.655 Section 105-74.655 Public Contracts and Property Management Federal Property Management Regulations System...-GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 105-74.655 Individual...

  11. 41 CFR 105-74.650 - Grant.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Grant. 105-74.650 Section 105-74.650 Public Contracts and Property Management Federal Property Management Regulations System...-GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 105-74.650 Grant. Grant...

  12. 21 CFR 99.105 - Recipients of information.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Recipients of information. 99.105 Section 99.105 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL... Disseminated § 99.105 Recipients of information. A manufacturer disseminating information on a new use under...

  13. 29 CFR 1910.105 - Nitrous oxide.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 5 2010-07-01 2010-07-01 false Nitrous oxide. 1910.105 Section 1910.105 Labor Regulations... OCCUPATIONAL SAFETY AND HEALTH STANDARDS Hazardous Materials § 1910.105 Nitrous oxide. The piped systems for the in-plant transfer and distribution of nitrous oxide shall be designed, installed, maintained, and...

  14. 46 CFR 111.105-41 - Battery rooms.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Battery rooms. 111.105-41 Section 111.105-41 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) ELECTRICAL ENGINEERING ELECTRIC SYSTEMS-GENERAL REQUIREMENTS Hazardous Locations § 111.105-41 Battery rooms. Each electrical installation in a battery room...

  15. 38 CFR 45.105 - Definitions.

    Science.gov (United States)

    2010-07-01

    ... private sector. (o) Recipient includes all contractors, subcontractors at any tier, and subgrantees at any... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Definitions. 45.105... RESTRICTIONS ON LOBBYING General § 45.105 Definitions. For purposes of this part: (a) Agency, as defined in 5 U...

  16. 33 CFR 105.415 - Amendment and audit.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Amendment and audit. 105.415 Section 105.415 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY MARITIME SECURITY MARITIME SECURITY: FACILITIES Facility Security Plan (FSP) § 105.415 Amendment and audit. (a) Amendments. (1) Amendments to a Facility Securit...

  17. 12 CFR 268.105 - Individual complaints.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 3 2010-01-01 2010-01-01 false Individual complaints. 268.105 Section 268.105... RULES REGARDING EQUAL OPPORTUNITY Board Program To Promote Equal Opportunity § 268.105 Individual... individual and the Board and to describe generally the action(s) or practice(s) that form the basis of the...

  18. 7 CFR 1942.105 - Environmental review.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 13 2010-01-01 2009-01-01 true Environmental review. 1942.105 Section 1942.105... § 1942.105 Environmental review. FmHA or its successor agency under Public Law 103-354 must conduct and document an environmental review for each proposed project in accordance with subpart G of part 1940 of...

  19. 46 CFR 57.06-5 - Production toughness testing.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 2 2010-10-01 2010-10-01 false Production toughness testing. 57.06-5 Section 57.06-5 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING WELDING AND BRAZING Production Tests § 57.06-5 Production toughness testing. (a) In addition to the test specimens required by...

  20. 18 CFR 1315.105 - Definitions.

    Science.gov (United States)

    2010-04-01

    ... services in the private sector. (o) Recipient includes all contractors, subcontractors at any tier, and... 18 Conservation of Power and Water Resources 2 2010-04-01 2010-04-01 false Definitions. 1315.105... LOBBYING General § 1315.105 Definitions. For purposes of this part: (a) Agency, as defined in 5 U.S.C. 552...

  1. 28 CFR 105.11 - Individuals not requiring a security risk assessment.

    Science.gov (United States)

    2010-07-01

    ... requiring a security risk assessment. (a) Citizens and nationals of the United States. A citizen or national... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Individuals not requiring a security risk assessment. 105.11 Section 105.11 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) CRIMINAL HISTORY...

  2. Performance test results of mock-up test facility of HTTR hydrogen production system

    International Nuclear Information System (INIS)

    Ohashi, Hirofumi; Inaba, Yoshitomo; Nishihara, Tetsuo

    2004-01-01

    For the purpose to demonstrate effectiveness of high-temperature nuclear heat utilization, Japan Atomic Energy Research Institute has been developing a hydrogen production system and has planned to connect the hydrogen production system to High Temperature Engineering Test Reactor (HTTR). Prior to construction of a HTTR hydrogen production system, a mock-up test facility was constructed to investigate transient behavior of the hydrogen production system and to establish system controllability. The Mock-up test facility with a full-scale reaction tube is an approximately 1/30-scale model of the HTTR hydrogen production system and an electric heater is used as a heat source instead of a reactor. After its construction, a performance test of the test facility was carried out in the same pressure and temperature conditions as those of the HTTR hydrogen production system to investigate its performance such as hydrogen production ability, controllability and so on. It was confirmed that hydrogen was stably produced with a hot helium gas about 120m 3 /h, which satisfy the design value, and thermal disturbance of helium gas during the start-up could be mitigated within the design value by using a steam generator. The mock-up test of the HTTR hydrogen production system using this facility will continue until 2004. (author)

  3. Flammable gas tank waste level reconciliation tank 241-SX-105

    International Nuclear Information System (INIS)

    Brevick, C.H.; Gaddie, L.A.

    1997-01-01

    Fluor Daniel Northwest was authorized to address flammable gas issues by reconciling the unexplained surface level increases in Tank 241-SX-105 (SX-105, typical). The trapped gas evaluation document states that Tank SX-105 exceeds the 25% of the lower flammable limit criterion, based on a surface level rise evaluation. The Waste Storage Tank Status and Leak Detection Criteria document, commonly referred to as the Welty Report is the basis for this letter report. The Welty Report is also a part of the trapped gas evaluation document criteria. The Welty Report contains various tank information, including: physical information, status, levels, and dry wells. The unexplained waste level rises were attributed to the production and retention of gas in the column of waste corresponding to the unaccounted for surface level rise. From 1973 through 1980, the Welty Report tracked Tank SX-105 transfers and reported a net cumulative change of 20.75 in. This surface level increase is from an unknown source or is unaccounted for. Duke Engineering and Services Hanford and Lockheed Martin Hanford Corporation are interested in determining the validity of unexplained surface level changes reported in the Welty Report based upon other corroborative sources of data. The purpose of this letter report is to assemble detailed surface level and waste addition data from daily tank records, logbooks, and other corroborative data that indicate surface levels, and to reconcile the cumulative unaccounted for surface level changes as shown in the Welty Report from 1973 through 1980. Tank SX-105 initially received waste from REDOX starting the second quarter of 1955. After June 1975, the tank primarily received processed waste (slurry) from the 242-S Evaporator/Crystallizer and transferred supernate waste to Tanks S-102 and SX-102. The Welty Report shows a cumulative change of 20.75 in. from June 1973 through December 1980

  4. 46 CFR 54.05-16 - Production toughness testing.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 2 2010-10-01 2010-10-01 false Production toughness testing. 54.05-16 Section 54.05-16... Toughness Tests § 54.05-16 Production toughness testing. (a) For vessels of welded construction, production... welding procedures shall be the same as used in the fabrication of the vessel. From each test plate, one...

  5. Removal Action Work Plan for 105-DR and 105-F Building Interim Safe Storage Projects and Ancillary Buildings

    International Nuclear Information System (INIS)

    Morton, M.R.

    2000-01-01

    This document contains the removal action work plan for the 105-DR and 105-F Reactor buildings and ancillary facilities. These buildings and facilities are located in the 100-D/DR and 100-F Areas of the Hanford Site, which is owned and operated by the US Department of Energy (DOE), in Benton County, Washington. The 100 Areas (including the 100-D/DR and 100-F Areas) of the Hanford Site were placed on the US Environmental Protection Agency's (EPA's) National Priorities List under the ''Comprehensive Environmental Response, Compensation, and Liability Act of 1980'' (CERCLA). The DOE has determined that hazardous substances in the 105-DR and 105-F Reactor buildings and four ancillary facilities present a potential threat to human health or the environment. The DOE has also determined that a non-time critical removal action is warranted at these facilities. Alternatives for conducting a non-time critical removal action were evaluated in the ''Engineering Evaluation/Cost Analysis for the 105-DR and 105-F Reactor Facilities and Ancillary Facilities'' (DOE-RL 1998a). The engineering evaluation/cost analysis (EE/CA) resulted in the recommendation to decontaminate and demolish the contaminated reactor buildings (except for the reactor blocks) and the ancillary facilities and to construct a safe storage enclosure (SSE) over the reactor blocks. The recommendation was approved in an action memorandum (Ecology et al. 1998) signed by the Washington State Department of Ecology (Ecology), EPA, and DOE. The DOE is the agency responsible for implementing the removal actions in the 105-D/DR and 105-F Areas. Ecology is the lead regulatory agency for facilities in the 100-D/DR Area, and EPA is the lead regulatory agency for facilities in the 100-F Area. The term ''lead regulator agency'' hereinafter, refers to these authorities. This removal action work plan supports implementation of the non-time critical removal action

  6. Comprehensive behavioral analysis of RNG105 (Caprin1) heterozygous mice: Reduced social interaction and attenuated response to novelty

    Science.gov (United States)

    Ohashi, Rie; Takao, Keizo; Miyakawa, Tsuyoshi; Shiina, Nobuyuki

    2016-01-01

    RNG105 (also known as Caprin1) is a major RNA-binding protein in neuronal RNA granules, and is responsible for mRNA transport to dendrites and neuronal network formation. A recent study reported that a heterozygous mutation in the Rng105 gene was found in an autism spectrum disorder (ASD) patient, but it remains unclear whether there is a causal relation between RNG105 deficiency and ASD. Here, we subjected Rng105+/− mice to a comprehensive behavioral test battery, and revealed the influence of RNG105 deficiency on mouse behavior. Rng105+/− mice exhibited a reduced sociality in a home cage and a weak preference for social novelty. Consistently, the Rng105+/− mice also showed a weak preference for novel objects and novel place patterns. Furthermore, although the Rng105+/− mice exhibited normal memory acquisition, they tended to have relative difficulty in reversal learning in the spatial reference tasks. These findings suggest that the RNG105 heterozygous knockout leads to a reduction in sociality, response to novelty and flexibility in learning, which are implicated in ASD-like behavior. PMID:26865403

  7. 47 CFR 25.105-25.108 - [Reserved

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 2 2010-10-01 2010-10-01 false [Reserved] 25.105-25.108 Section 25.105-25.108 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) COMMON CARRIER SERVICES SATELLITE COMMUNICATIONS General §§ 25.105-25.108 [Reserved] ...

  8. Fibrin degradation products blood test

    Science.gov (United States)

    ... behind when clots dissolve in the blood. A blood test can be done to measure these products. ... Certain medicines can change blood test results. Tell your health care provider about all the medicines you take. Your provider will tell you if you need ...

  9. Dosimetry of 64Cu-DOTA-AE105, a PET tracer for uPAR imaging

    International Nuclear Information System (INIS)

    Persson, Morten; El Ali, Henrik H.; Binderup, Tina; Pfeifer, Andreas; Madsen, Jacob; Rasmussen, Palle; Kjaer, Andreas

    2014-01-01

    64 Cu-DOTA-AE105 is a novel positron emission tomography (PET) tracer specific to the human urokinase-type plasminogen activator receptor (uPAR). In preparation of using this tracer in humans, as a new promising method to distinguish between indolent and aggressive cancers, we have performed PET studies in mice to evaluate the in vivo biodistribution and estimate human dosimetry of 64 Cu-DOTA-AE105. Methods: Five mice received iv tail injection of 64 Cu-DOTA-AE105 and were PET/CT scanned 1, 4.5 and 22 h post injection. Volume-of-interest (VOI) were manually drawn on the following organs: heart, lung, liver, kidney, spleen, intestine, muscle, bone and bladder. The activity concentrations in the mentioned organs [%ID/g] were used for the dosimetry calculation. The %ID/g of each organ at 1, 4.5 and 22 h was scaled to human value based on a difference between organ and body weights. The scaled values were then exported to OLINDA software for computation of the human absorbed doses. The residence times as well as effective dose equivalent for male and female could be obtained for each organ. To validate this approach, of human projection using mouse data, five mice received iv tail injection of another 64 Cu-DOTA peptide-based tracer, 64 Cu-DOTA-TATE, and underwent same procedure as just described. The human dosimetry estimates were then compared with observed human dosimetry estimate recently found in a first-in-man study using 64 Cu-DOTA-TATE. Results: Human estimates of 64 Cu-DOTA-AE105 revealed the heart wall to receive the highest dose (0.0918 mSv/MBq) followed by the liver (0.0815 mSv/MBq), All other organs/tissue were estimated to receive doses in the range of 0.02–0.04 mSv/MBq. The mean effective whole-body dose of 64 Cu-DOTA-AE105 was estimated to be 0.0317 mSv/MBq. Relatively good correlation between human predicted and observed dosimetry estimates for 64 Cu-DOTA-TATE was found. Importantly, the effective whole body dose was predicted with very high

  10. Dosimetry of 64Cu-DOTA-AE105, a PET tracer for uPAR imaging.

    Science.gov (United States)

    Persson, Morten; El Ali, Henrik H; Binderup, Tina; Pfeifer, Andreas; Madsen, Jacob; Rasmussen, Palle; Kjaer, Andreas

    2014-03-01

    (64)Cu-DOTA-AE105 is a novel positron emission tomography (PET) tracer specific to the human urokinase-type plasminogen activator receptor (uPAR). In preparation of using this tracer in humans, as a new promising method to distinguish between indolent and aggressive cancers, we have performed PET studies in mice to evaluate the in vivo biodistribution and estimate human dosimetry of (64)Cu-DOTA-AE105. Five mice received iv tail injection of (64)Cu-DOTA-AE105 and were PET/CT scanned 1, 4.5 and 22 h post injection. Volume-of-interest (VOI) were manually drawn on the following organs: heart, lung, liver, kidney, spleen, intestine, muscle, bone and bladder. The activity concentrations in the mentioned organs [%ID/g] were used for the dosimetry calculation. The %ID/g of each organ at 1, 4.5 and 22 h was scaled to human value based on a difference between organ and body weights. The scaled values were then exported to OLINDA software for computation of the human absorbed doses. The residence times as well as effective dose equivalent for male and female could be obtained for each organ. To validate this approach, of human projection using mouse data, five mice received iv tail injection of another (64)Cu-DOTA peptide-based tracer, (64)Cu-DOTA-TATE, and underwent same procedure as just described. The human dosimetry estimates were then compared with observed human dosimetry estimate recently found in a first-in-man study using (64)Cu-DOTA-TATE. Human estimates of (64)Cu-DOTA-AE105 revealed the heart wall to receive the highest dose (0.0918 mSv/MBq) followed by the liver (0.0815 mSv/MBq), All other organs/tissue were estimated to receive doses in the range of 0.02-0.04 mSv/MBq. The mean effective whole-body dose of (64)Cu-DOTA-AE105 was estimated to be 0.0317 mSv/MBq. Relatively good correlation between human predicted and observed dosimetry estimates for (64)Cu-DOTA-TATE was found. Importantly, the effective whole body dose was predicted with very high precision

  11. 28 CFR 105.27 - Miscellaneous provisions.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Miscellaneous provisions. 105.27 Section 105.27 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) CRIMINAL HISTORY BACKGROUND CHECKS... has elected to opt out; or (ii) A participating State that has not yet established a process for...

  12. Application of Bacillus sp. TAT105 to reduce ammonia emissions during pilot-scale composting of swine manure.

    Science.gov (United States)

    Kuroda, Kazutaka; Tanaka, Akihiro; Furuhashi, Kenich; Nakasaki, Kiyohiko

    2017-12-01

    Thermophilic ammonium-tolerant bacterium Bacillus sp. TAT105 grows and reduces ammonia (NH 3 ) emissions by assimilating ammonium nitrogen during composting of swine feces. To evaluate the efficacy of a biological additive containing TAT105 at reducing NH 3 emissions, composting tests of swine manure on a pilot scale (1.8 m 3 ) were conducted. In the TAT105-added treatment, NH 3 emissions and nitrogen loss were lower than those in the control treatment without TAT105. No significant difference was detected in losses in the weight and volatile solids between the treatments. Concentration of thermophilic ammonium-tolerant bacteria in the compost increased in both treatments at the initial stage of composting. In the TAT105-added treatment, bacterial concentration reached ~10 9 colony-forming units per gram of dry matter, several-fold higher than that in the control and stayed at the same level until the end. These results suggest that TAT105 grows during composting and reduces NH 3 emissions in TAT105-added treatment.

  13. Endurance test for IR rig for RI production assembly (test procedure)

    International Nuclear Information System (INIS)

    Chung, Heung June; Ryu, Jeong Soo

    2000-08-01

    This test procedure details the test loop, test method, and test procedure for pressure drop, vibration and endurance test of IR Rig for RI production. From the pressure drop test, the hydraulic design requirements of the capsule are verified. HANARO limit condition is checked and the compatibility with HANARO core is verified. From flow induced vibration test vibration frequency and displacement are investigated. The wear of IR Rig is investigated through endurance test, and these data are used to evaluate the expected wear at maximum resident time of the IR Rig for RI production

  14. 41 CFR 105-55.014 - Liquidation of collateral.

    Science.gov (United States)

    2010-07-01

    ... collateral. 105-55.014 Section 105-55.014 Public Contracts and Property Management Federal Property... Administration 55-COLLECTION OF CLAIMS OWED THE UNITED STATES § 105-55.014 Liquidation of collateral. (a) The General Services Administration (GSA) will liquidate security or collateral through the exercise of a...

  15. 48 CFR 873.105 - Acquisition planning.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Acquisition planning. 873.105 Section 873.105 Federal Acquisition Regulations System DEPARTMENT OF VETERANS AFFAIRS DEPARTMENT... planning. (a) Acquisition planning is an indispensable component of the total acquisition process. (b) For...

  16. 41 CFR 105-8.160 - Communications.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Communications. 105-8.160 Section 105-8.160 Public Contracts and Property Management Federal Property Management Regulations... would result in a fundamental alteration in the nature of a program or activity or in undue financial...

  17. 48 CFR 39.105 - Privacy.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Privacy. 39.105 Section 39... CONTRACTING ACQUISITION OF INFORMATION TECHNOLOGY General 39.105 Privacy. Agencies shall ensure that contracts for information technology address protection of privacy in accordance with the Privacy Act (5 U.S.C...

  18. 44 CFR 18.105 - Definitions.

    Science.gov (United States)

    2010-10-01

    ... services in the private sector. (o) Recipient includes all contractors, subcontractors at any tier, and... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Definitions. 18.105 Section... HOMELAND SECURITY GENERAL NEW RESTRICTIONS ON LOBBYING General § 18.105 Definitions. For purposes of this...

  19. 14 CFR 1217.105 - Procedures.

    Science.gov (United States)

    2010-01-01

    ... Associated Services Agreement. (d) If articles procured under contract by NASA are imported prior to... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Procedures. 1217.105 Section 1217.105 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION DUTY-FREE ENTRY OF SPACE ARTICLES § 1217...

  20. 46 CFR 111.105-1 - Applicability; definition.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Applicability; definition. 111.105-1 Section 111.105-1 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) ELECTRICAL ENGINEERING ELECTRIC SYSTEMS-GENERAL REQUIREMENTS Hazardous Locations § 111.105-1 Applicability; definition. This subpart applies to...

  1. 41 CFR 105-74.620 - Cooperative agreement.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Cooperative agreement. 105-74.620 Section 105-74.620 Public Contracts and Property Management Federal Property Management... Administration 74-GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 105-74...

  2. 41 CFR 105-74.610 - Controlled substance.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Controlled substance. 105-74.610 Section 105-74.610 Public Contracts and Property Management Federal Property Management... Administration 74-GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 105-74...

  3. 49 CFR 229.105 - Steam generator number.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Steam generator number. 229.105 Section 229.105..., DEPARTMENT OF TRANSPORTATION RAILROAD LOCOMOTIVE SAFETY STANDARDS Safety Requirements Steam Generators § 229.105 Steam generator number. An identification number shall be marked on the steam generator's...

  4. 42 CFR 56.105 - Accord with health planning.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Accord with health planning. 56.105 Section 56.105... HEALTH SERVICES General Provisions § 56.105 Accord with health planning. A grant may be made under this... appropriate health planning agencies have been met. ...

  5. Dragon project reference design assessment study for a 528 MW (E) thorium cycle high temperature gas cooled reactor

    International Nuclear Information System (INIS)

    Hosegood, S.B.

    1967-05-01

    The report presents an assessment of the feasibility, safety and cost of a large nuclear power station employing a high temperature gas-cooled reactor. A thermal output 1250 MW was chosen for the study, resulting in a net electrical output of 528.34 MW from a single reactor station, or 1056.7 MW from a twin reactor station. A reference design has been developed and is described. The reactor uses a U-235/Th-232/U-233 fuel cycle, on a feed and breed basis. It is believed that such a reactor could be built at an early date, requiring only a relatively modest development programme. Building costs are estimated to be Pound46.66/kW for a single unit station and Pound42.6/kW for a twin station, with power generation costs of 1.67p/kWh and 1.50p/kWh respectively. Optimisation studies have not been carried out and it should be possible to improve on the costs. The design has been made as flexible as possible to allow units of smaller or larger outputs to be designed with a minimum of change. (U.K.)

  6. 5 CFR 5502.105 - Agency procedures.

    Science.gov (United States)

    2010-01-01

    ....105 Administrative Personnel DEPARTMENT OF HEALTH AND HUMAN SERVICES SUPPLEMENTAL FINANCIAL DISCLOSURE REQUIREMENTS FOR EMPLOYEES OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES § 5502.105 Agency procedures. (a) The designated agency ethics official or, with the concurrence of the designated agency ethics official, each of...

  7. 41 CFR 105-74.640 - Employee.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Employee. 105-74.640...-GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 105-74.640 Employee. (a) Employee means the employee of a recipient directly engaged in the performance of work under the award...

  8. 41 CFR 105-70.033 - Witnesses.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Witnesses. 105-70.033 Section 105-70.033 Public Contracts and Property Management Federal Property Management Regulations System... may proceed by leading questions only if the witness is a hostile witness, an adverse party, or a...

  9. LBNO-DEMO (WA105): a large demonstrator of the Liquid Argon double phase TPC

    CERN Document Server

    Trzaska, Wladyslaw Henryk

    2015-01-01

    LBNO-DEMO (WA105) is a large demonstrator of the double phase liquid argon TPC intended to develop and test the main elements of the GLACIER-based design for the purpose of scaling it up to the 10–50 kton size needed for Long Baseline Neutrino Oscillation studies. The crucial components of the design are: ultra-high argon purity in non-evacuable tank, long drifts, very high drift voltages, large area Micro Pattern Gas Detectors, and cold preamplifiers. The active volume of the demonstrator is 666 m3 (approximately 300t). WA105 is under construction at CERN and will be exposed to charged particle beams (0.5-20 GeV/c) in the North Area in 2018. The data will provide the necessary calibration of the detector performance and benchmark reconstruction algorithms. This project is a crucial milestone for the long baseline neutrino program, including projects like LBNO and DUNE.

  10. 36 CFR 1211.105 - Definitions.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Definitions. 1211.105 Section 1211.105 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION GENERAL RULES... the sale or transfer of such property, if the Federal share of the fair market value of the property...

  11. A Biocontrol Strain of Bacillus subtilis WXCDD105 Used to Control Tomato Botrytis cinerea and Cladosporium fulvum Cooke and Promote the Growth of Seedlings

    Directory of Open Access Journals (Sweden)

    Hui Wang

    2018-05-01

    Full Text Available In this study, a strain named WXCDD105, which has strong antagonistic effects on Botrytis cinerea and Cladosporium fulvum Cooke, was screened out from the rhizosphere of healthy tomato plants. The tomato plants had inhibition diameter zones of 5.00 mm during the dual culture for four days. Based on the morphological and physiological characteristics, the 16S rDNA sequence, and the gyrB gene sequence analysis, the strain WXCDD105 was identified as Bacillus subtilis suBap. subtilis. The results of the mycelial growth test showed that the sterile filtrate of the strain WXCDD105 could significantly inhibit mycelial growth of Botrytis cinerea and Cladosporium fulvum Cooke. The inhibition rates were 95.28 and 94.44%, respectively. The potting experiment showed that the strain WXCDD105 made effective the control of tomato gray mold and tomato leaf mold. The control efficiencies were 74.70 and 72.07%. The antagonistic test results showed that the strain WXCDD105 had different degrees of inhibition on 10 kinds of plant pathogenic fungi and the average inhibition rates were more than 80%. We also found that the strain WXCDD105 stimulated both the seed germination and seedling growth of tomatoes. Using the fermentation liquid of WXCDD105 (108 cfu·mL−1 to treat the seeds, the germination rate and radicle length were increased. Under the treatment of the fermentation liquid of the strain WXCDD105 (106 cfu·mL−1, nearly all physiological indexes of tomato seedlings were significantly higher than that of the control groups. This could not only keep the nutritional quality of tomato fruits but also prevent them from rotting. This study provided us with an excellent strain for biological control of tomato gray mold, tomato leaf mold, and tomato growth promotion. This also laid the technical foundation for its application.

  12. Dicty_cDB: SFF105 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SF (Link to library) SFF105 (Link to dictyBase) - - - Contig-U14516-1 SFF105Z (Link... to Original site) - - SFF105Z 217 - - - - Show SFF105 Library SF (Link to library) Clone ID SFF105 (Link to dict...yBase) Atlas ID - NBRP ID - dictyBase ID - Link to Contig Contig-U14516-1 Original site URL http://dict...pieces. 44 0.77 1 CF971786 |CF971786.1 AUB_IfLvr00258 Ictalurus furcatus liver cDNA library Ictalurus furcat...endoplasmic reticulum >> prediction for SFF105 is cyt 5' end seq. ID - 5' end seq. - Length of 5' end seq. -

  13. 41 CFR 105-1.109-51 - Arrangement.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Arrangement. 105-1.109-51 Section 105-1.109-51 Public Contracts and Property Management Federal Property Management Regulations System (Continued) GENERAL SERVICES ADMINISTRATION 1-INTRODUCTION 1.1-Regulations System § 105-1...

  14. 41 CFR 105-54.304 - Cost guidelines.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Cost guidelines. 105-54.304 Section 105-54.304 Public Contracts and Property Management Federal Property Management... Administration 54-ADVISORY COMMITTEE MANAGEMENT 54.3-Advisory Committee Procedures § 105-54.304 Cost guidelines...

  15. 40 CFR 59.105 - Reporting requirements.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 5 2010-07-01 2010-07-01 false Reporting requirements. 59.105 Section... Volatile Organic Compound Emission Standards for Automobile Refinish Coatings § 59.105 Reporting requirements. (a) Each regulated entity must submit an initial report no later than January 11, 1999 or within...

  16. Radiological testing of products containing radioactivity

    International Nuclear Information System (INIS)

    Dixon, D.W.; Knight, A.

    1980-01-01

    Consumer products containing radioactive substances are tested by NRPB to determine how much radioactive material is likely to be released from a product if it is misused or accidentally damaged. Such testing is briefly described with particular reference to ionisation chamber smoke detectors, liquid crystal display watches illuminated with gaseous tritium light sources and anti-static brushes containing polonium-210 in the form of ceramic microspheres. (U.K.)

  17. 18 CFR 1300.105 - National origin harassment.

    Science.gov (United States)

    2010-04-01

    ... harassment. 1300.105 Section 1300.105 Conservation of Power and Water Resources TENNESSEE VALLEY AUTHORITY STANDARDS OF CONDUCT FOR EMPLOYEES OF TENNESSEE VALLEY AUTHORITY § 1300.105 National origin harassment. It is TVA policy that all TVA employees are responsible for assuring that the workplace is free from...

  18. 41 CFR 105-8.170-13 - Delegation.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Delegation. 105-8.170-13 Section 105-8.170-13 Public Contracts and Property Management Federal Property Management Regulations... HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY GENERAL SERVICES ADMINISTRATION § 105-8.170-13 Delegation...

  19. 41 CFR 105-1.101-50 - Exclusions.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Exclusions. 105-1.101-50 Section 105-1.101-50 Public Contracts and Property Management Federal Property Management Regulations System (Continued) GENERAL SERVICES ADMINISTRATION 1-INTRODUCTION 1.1-Regulations System § 105-1.101-50...

  20. 46 CFR 14.105 - Disclosure and privacy.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Disclosure and privacy. 14.105 Section 14.105 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY MERCHANT MARINE OFFICERS AND SEAMEN SHIPMENT AND DISCHARGE OF MERCHANT MARINERS General § 14.105 Disclosure and privacy. The Coast Guard makes information...

  1. 7 CFR 1950.105 - Interest rate.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 14 2010-01-01 2009-01-01 true Interest rate. 1950.105 Section 1950.105 Agriculture... rate. (a) The Soldiers and Sailors Relief Act requires that the effective interest rate charged a... Supervisor will send the borrower a letter which states that the interest rate on the borrower's FmHA or its...

  2. 46 CFR 57.06-4 - Production testing specimen requirements.

    Science.gov (United States)

    2010-10-01

    ... WELDING AND BRAZING Production Tests § 57.06-4 Production testing specimen requirements. (a) For test... 46 Shipping 2 2010-10-01 2010-10-01 false Production testing specimen requirements. 57.06-4... to welding shall not throw the finished test plate out of line by an angle of over 5°. (c) Where the...

  3. 41 CFR 105-68.1005 - State.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false State. 105-68.1005...-GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) Definitions § 105-68.1005 State. (a) State means— (1) Any of the states of the United States; (2) The District of Columbia; (3) The Commonwealth of Puerto...

  4. Removal Action Workplan for the 105-DR and 105-F Building Interim Safe Storage Projects and Ancillary Buildings

    International Nuclear Information System (INIS)

    Rodovsky, T. J.

    1999-01-01

    This document is the removal action workplan (RAW) for the 105-DR and 105-F Reactor Buildings and ancillary facilities. These buildings and facilities are located in the 100-D/DR and 100-F Areas of the Hanford Site in Benton County, Washington, which is owned and operated by the U.S. Department of Energy (DOE). The 100 Areas (including 100-D/DR and 100-F Areas) of the Hanford Site were placed on the U.S. Environmental Protection Agency's (EPA) National Priorities List under the Comprehensive Environmental Response, Compensation,and Liability Act of 1980 (CERCLA). DOE has determined that hazardous substances in the 105-DR and 105-F Reactor Buildings and four ancillary facilities present a potential threat to human health or the environment DOE has also determined that a non-time critical removal action is warranted at these facilities

  5. Application Anti Microbial Activity Test and Direct Inoculation of Urinary Specimen Test to Increase the Quality of Results and Decrease the Production Cost in Clinical Microbiology Laboratory, Sanglah General Hospital Hospital, Bali-Indonesia

    Directory of Open Access Journals (Sweden)

    Nyoman Sri-Budayanti

    2012-05-01

    Full Text Available Objective: Urinary tract infection (UTI is the most common bacterial infection in general practice and in hospitals. Fast and accurate urine culture and sensitivity test are needed for adequate therapy. Anti Microbial Activity test (AMA test that is used to detect the presence of antibiotics in urine specimens is not commonly used in clinical microbiology laboratories. Some laboratories are still using indirect inoculation technique using enriched media before inoculating onto the agar media. The aim of this research is to compare results of urinary examination of direct inoculation technique with AMA test with indirect inoculation technique without AMA test.Methods: A number of 210 urine specimens were collected in Clinical Microbiology Laboratory at Sanglah General Hospital within a time period between 16 June until 16 July 2009.Results: Antibiotics were detected in 40% of the urinary specimens; whereas 48.1% showed no evidence of UTI, that is negative AMA test and sterile urinary culture or colony growth < 105 CFU/ml. Only 11.9% of the specimens indicates urinary tract infections. The examination can be completed within 2-3 days which is shorter than indirect inoculation test which require 5-7 days. Direct inoculation technique can reduce the cost of production three-fold the costs require for an indirect inoculation test.Conclusions: Application of AMA test and direct inoculation technique can give results more rapidly, reliable and useful for clinicians. This also decrease the laboratory’s cost of production.

  6. 46 CFR 111.105-35 - Vessels carrying coal.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Vessels carrying coal. 111.105-35 Section 111.105-35...-GENERAL REQUIREMENTS Hazardous Locations § 111.105-35 Vessels carrying coal. (a) The following are Class II, Division 1, (Zone 10 or Z) locations on a vessel that carries coal: (1) The interior of each coal...

  7. Recovery of creep properties of the nickel-base superalloy nimonic 105

    CSIR Research Space (South Africa)

    Girdwood, RB

    1996-01-01

    Full Text Available Uniaxial constant stress creep tests were performed on the wrought nickel-base superalloy Nimonic 105. Entire creep curves were recorded and curve shapes analysed using the Theta Projection Concept. Rejuventive procedures were applied to pre...

  8. 41 CFR 105-71.133 - Supplies.

    Science.gov (United States)

    2010-07-01

    ... aggregate fair market value upon termination or completion of the award, and if the supplies are not needed... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Supplies. 105-71.133...-Award Requirements/Changes, Property, and Subawards § 105-71.133 Supplies. (a) Title. Title to supplies...

  9. 105-C Facility characterization plan

    International Nuclear Information System (INIS)

    Miller, R.L.

    1997-01-01

    This facility characterization plan is a site-specific document that describes how quantification and qualification of the radiological sources and the radioactive contamination in the 105-C Building will be accomplished. Characterization of hazardous materials will be addressed in a separate plan. This plan was developed from review of video tapes, photographs, and records. The purpose of this characterization plan is to provide an efficient and cost-effective method for determining the distribution of radioactive contamination at the 105-C Facility

  10. Dissolution test for low-activity waste product acceptance

    International Nuclear Information System (INIS)

    Ebert, W. L.

    1998-01-01

    We have measured the mean and standard deviation of the solution concentrations of B, Na, and Si attained in replicate dissolution tests conducted at temperatures of 20, 40, and 70 C, for durations of 3 and 7 days, and at glass/water mass ratios of 1:10 and 1:1. These and other tests were conducted to evaluate the adequacy of the test methods specified in privatization contracts and to develop a data base that can be used to evaluate the reliability of reported results for tests performed on the waste products. Tests were conducted with a glass that we formulated to be similar to low-activity waste products that will be produced during the remediation of Hanford tank wastes. Statistical analyses indicated that, while the mean concentrations of B, Na, and Si were affected by the values of test parameters, the standard deviation of replicate tests was not. The precision of the tests was determined primarily by uncertainties in the analysis of the test solutions. Replicate measurements of other glass properties that must be reported for Hanford low-activity waste products were measured to evaluate the possible adoption of the glass used in these tests as a standard test material for the product acceptance process

  11. Engineering study: 105KE to 105KW Basin fuel and sludge transfer. Final report

    International Nuclear Information System (INIS)

    Gant, R.G.

    1994-01-01

    In the last five years, there have been three periods at the 105KE fuel storage basin (KE Basin) where the reported drawdown test rates were in excess of 25 gph. Drawdown rates in excess of this amount have been used during past operations as the primary indicators of leaks in the basin. The latest leak occurred in March, 1993. The reported water loss from the KE Basin was estimated at 25 gph. This engineering study was performed to identify and recommend the most feasible and practical method of transferring canisters of irradiated fuel and basin sludge from the KE Basin to the 105KW fuel storage basin (KW Basin). Six alternatives were identified during the performance of this study as possible methods for transferring the fuel and sludge from the KE Basin to the KW Basin. These methods were then assessed with regard to operations, safety, radiation exposure, packaging, environmental concerns, waste management, cost, and schedule; and the most feasible and practical methods of transfer were identified. The methods examined in detail in this study were based on shipment without cooling water except where noted: Transfer by rail using the previously used transfer system and water cooling; Transfer by rail using the previously used transfer system (without water cooling); Transfer by truck using the K Area fuel transfer cask (K Area cask); Transfer by truck using a DOE shipping cask; Transfer by truck using a commercial shipping cask; and Transfer by truck using a new fuel shipping cask

  12. L2 Writing in Test and Non-test Situations: Process and Product

    Directory of Open Access Journals (Sweden)

    Baraa Khuder

    2015-02-01

    Full Text Available Test writers sometimes complain they cannot perform to their true abilities because of time constraints. We therefore examined differences in terms of process and product between texts produced under test and non-test conditions. Ten L2 postgraduates wrote two argumentative essays, one under test conditions, with only forty minutes being allowed and without recourse to resources, and one under non-test conditions, with unlimited time as well as access to the Internet. Keystroke logging, screen capture software, and stimulated recall protocols were used, participants explaining and commenting on their writing processes. Sixteen writing process types were identified. Higher proportions of the processes of translation and surface revision were recorded in the test situation, while meaningful revision and evaluation were both higher in the non-test situation. There was a statistically significant difference between time allocation for different processes at different stages. Experienced teachers awarded the non-test texts a mean score of almost one point (0.8 higher. A correlational analysis examining the relationship between writing process and product quality showed that while the distribution of writing processes can have an impact on text quality in the test situation, it had no effect on the product in the non-test situation.

  13. Production of the Allergenic Protein Alt a 1 by Alternaria Isolates from Working Environments

    Directory of Open Access Journals (Sweden)

    Justyna Skóra

    2015-02-01

    Full Text Available The aim of the study was to evaluate the ability of Alternaria isolates from workplaces to produce Alt a 1 allergenic protein, and to analyze whether technical materials (cellulose, compost, leather present within the working environment stimulate or inhibit Alt a 1 production (ELISA test. Studies included identification of the isolated molds by nucleotide sequences analyzing of the ITS1/ITS2 regions, actin, calmodulin and Alt a 1 genes. It has been shown that Alternaria molds are significant part of microbiocenosis in the archive, museum, library, composting plant and tannery (14%–16% frequency in the air. The presence of the gene encoding the Alt a 1 protein has been detected for the strains: Alternaria alternata, A. lini, A. limoniasperae A. nobilis and A. tenuissima. Environmental strains produced Alt a 1 at higher concentrations (1.103–6.528 ng/mL than a ATCC strain (0.551–0.975 ng/mL. It has been shown that the homogenization of the mycelium and the use of ultrafiltration allow a considerable increase of Alt a 1 concentration. Variations in the production of Alt a 1 protein, depend on the strain and extraction methods. These studies revealed no impact of the technical material from the workplaces on the production of Alt a 1 protein.

  14. 41 CFR 105-68.905 - Affiliate.

    Science.gov (United States)

    2010-07-01

    ... management, ownership, or principal employees as the excluded person. ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Affiliate. 105-68.905 Section 105-68.905 Public Contracts and Property Management Federal Property Management Regulations System...

  15. Production and test of the LHCb Muon Chamber

    CERN Multimedia

    2005-01-01

    - The Muon System of LHCb - The Multi-Wire Proportional Chambers for LHCb - Wire tension meter - Wire pitch measurement - Gas leakage test - Test with cosmic rays - Production and test summary - Gap gain uniformity - Production and test summary

  16. Dicty_cDB: SSF105 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available SS (Link to library) SSF105 (Link to dictyBase) - - - Contig-U16581-1 SSF105F (Link... to Original site) SSF105F 432 - - - - - - Show SSF105 Library SS (Link to library) Clone ID SSF105 (Link to dict...yBase) Atlas ID - NBRP ID - dictyBase ID - Link to Contig Contig-U16581-1 Original site URL http://dict...g significant alignments: (bits) Value N D16417 |D16417.1 Dictyostelium discoideum mRNA. 387 e-126 3 BZ46365...028890 |BM028890.1 IpSkn01670 Skin cDNA library Ictalurus punctatus cDNA 5' similar to Ict

  17. Information/testing strategy for identification of substances with endocrine disrupting properties

    DEFF Research Database (Denmark)

    Hass, Ulla; Christiansen, Sofie; Bjerregaard, Poul

    This report has been prepared by the Danish Centre on Endocrine Disrupters (CeHoS) as a project contracted by the Danish Environmental Protection Agency. The Danish Centre on Endocrine Disrupters is an interdisciplinary scientific network without walls. The main purpose of the Centre is to build ...... of substances with endocrine disrupting properties under various legislative frameworks, including REACH (EC No 1907/2006), the Plant Protection Products Regulation (PPPR) (EC No 1107/2009) and the Biocidal Products Regulation (BPR) (EC No 528/2012) ....

  18. PHARMACEUTICAL QUALITY OF GENERIC ATORVASTATIN PRODUCTS COMPARED WITH THE INNOVATOR PRODUCT: A NEED FOR REVISING PRICING POLICY IN PALESTINE.

    Science.gov (United States)

    Shawahna, Ramzi; Hroub, Abdel Kareem; Abed, Eliama; Jibali, Sondos; Al-Saghir, Ruba; Zaid, Abdel Naser

    2016-01-01

    Atorvastatin reduces morbidity and mortality due to cardiovascular events. This study was conducted to assess the prices and pharmaceutical quality of innovator atorvastatin 20 mg with its locally available generics in Palestine and to assess the suitability of their interchangeability. The prices of innovator and generic atorvastatin 20 mg were determined and compared. Innovator atorvastatin and four generic products were tested for their pharmaceutical quality. Tablets were tested for their drug contents, weight uniformity, hardness, disintegration and dissolution. Three out of four generics were less expensive than the innovator. Pharmaceutical quality assessments were satisfactory and within limits for all atorvastatin tested products. The average weight ranged from 206.6 ± 8.40 to 330 ± 3.92 mg and the %RSDs were within the permitted limits as per USP. Tablet hardness ranged from 102 ± 1.41 to 197.4 ± 6.88 kg and drug contents ranged from 92.2% to 105.3%. All products disintegrated within permitted time limits and showed very rapid dissolution. Products released more than 85% of their drug contents in less than 15 min. Our results showed that all tested innovator and generic atorvastatin products were of good pharmaceutical quality. Despite the lack of in vivo evaluation, our results indicate that these products are equivalent in vitro. Considering the in vitro release characteristics, these products might be used interchangeably. However, regulatory authorities permit the use of in vitro data in establishing similarity between immediate release oral dosage forms containing biopharmaceutical classification system class I and III drugs only.

  19. Test Marketing in New Product Development

    Science.gov (United States)

    Klompmaker, Jay E.; And Others

    1976-01-01

    Discusses the role of test marketing in new product development, based on interviews with marketing executives. Attempts to clarify when a test market should be done, what its aims should be, and how it should be used. (JG)

  20. Lack of developmental and reproductive toxicity of 2,3,3',4,4'-pentachlorobiphenyl (PCB-105) in Ring-Necked Pheasants

    Science.gov (United States)

    Hornung, M.W.; Miller, L.; Goodman, B.; Melancon, M.J.; Peterson, R.E.

    1998-01-01

    Mono-ortho PCBs are global contaminants of wildlife with the potential to produce toxicity by an aryl hydrocarbon receptor (AhR)-mediated mechanism. To determine the potency of 2,3,3',4,4'pentachlorobiphenyl (PCB-105) for producing reproductive and developmental toxicity, adult ring-necked pheasant hens (Phasianus colchicus) were orally dosed with 0, 0.06, 0.6 or 6 mg PCB105/kg hen/week for 10 weeks to achieve cumulative doses of 0, 0.6, 6, or 60 mg PCB -105/hen after which hens were bred with untreated roosters once per week for 8 weeks. Except at week 6 of the egglaying period when cumulative egg production in the 6mg PCB 105/hen group was greater than controls, fertilized egg production was not significantly different between treatment groups. Embryo mortality and chick mortality were not significantly different between treatment groups. Total body and heart weights of all chicks 1 day posthatch (dph) were not different between groups, however liver weights of chicks from the 60mg/kg treatment groups were greater than controls at 1 dph. The first chick to hatch from each hen was reared to 21 dph and among these birds the total body, liver and heart weights were not different between groups. There were no dose-related malformations of the beak or limbs, and no signs of subcutaneous edema, ascites, or pericardial edema in chicks at 1 or 21 dph. Hepatic microsomal monooxygenase activities [ethoxyresorufin-O-dealkylase (EROD), benzyloxyresorufin-O-dealkylase (BROD), and methyloxyresorufin-O-dealkylase (MROD)] were significantly elevated in chicks at 1 dph from hens given a cumulative PCB105 dose of 6 mg/kg and in chicks at 21 dph from hens given a cumulative PCB dose of 60 mg/kg. These results indicate that a cumulative PCB-105 dose up to 60 mg/kg hen does not decrease the production of fertilized eggs or increase embryo or chick mortality in ring-necked pheasants, but does increase chick hepatic monooxygenase activity.

  1. 41 CFR 105-68.350 - What must I do if I learn of information required under § 105-68.335 after entering into a...

    Science.gov (United States)

    2010-07-01

    ... General Services Administration? 105-68.350 Section 105-68.350 Public Contracts and Property Management Federal Property Management Regulations System (Continued) GENERAL SERVICES ADMINISTRATION Regional... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What must I do if I...

  2. Earthworm cast production as a new behavioural biomarker for toxicity testing

    Energy Technology Data Exchange (ETDEWEB)

    Capowiez, Yvan, E-mail: capowiez@avignon.inra.f [INRA, UR1115 ' Plantes et Systemes Horticoles' , Domaine Saint Paul, 84914 Avignon Cedex 09 (France); Dittbrenner, Nils [INRA, UR1115 ' Plantes et Systemes Horticoles' , Domaine Saint Paul, 84914 Avignon Cedex 09 (France); Animal Physiological Ecology, University of Tuebingen, Konrad-Adenauer-Str. 20, D-72072 Tuebingen (Germany); Rault, Magali [UAPV, UMR406 ' Abeilles et Environnement' , Domaine Saint Paul, 84914 Avignon Cedex 09 (France); Triebskorn, Rita [Animal Physiological Ecology, University of Tuebingen, Konrad-Adenauer-Str. 20, D-72072 Tuebingen (Germany); Hedde, Mickael [INRA, UR251 ' PESSAC' , RD10, 78026 Versailles Cedex (France); Mazzia, Christophe [UAPV, UMR406 ' Abeilles et Environnement' , Domaine Saint Paul, 84914 Avignon Cedex 09 (France)

    2010-02-15

    There is currently a lack of ecotoxicity tests adapted to earthworm species of higher ecological relevance and whose endpoints could be directly related to their ecological role in the soil. We propose a new and relatively simple ecotoxicity test based on the estimation of cast production (CP) by Lumbricus terrestris under laboratory conditions. CP was found to be linearly correlated to earthworm biomass and to be greatly influenced by soil water content. Azinphos-methyl had no effect on CP at all the concentrations tested. Significant decreases were observed at the normal application rate for other pesticides with (imidacloprid, carbaryl, methomyl) or without (ethyl-parathion and chlorpyrifos-ethyl) a clear concentration-effect response. For the highest concentration tested, reduction in CP varied between 35 and 67%. CP is straightforward and rapidly measured and ecologically meaningful. We thus believe it to be of great use as an endpoint in ecotoxicity testing. - Cast production of Lumbricus terrestris is affected by pesticides under laboratory conditions.

  3. Earthworm cast production as a new behavioural biomarker for toxicity testing

    International Nuclear Information System (INIS)

    Capowiez, Yvan; Dittbrenner, Nils; Rault, Magali; Triebskorn, Rita; Hedde, Mickael; Mazzia, Christophe

    2010-01-01

    There is currently a lack of ecotoxicity tests adapted to earthworm species of higher ecological relevance and whose endpoints could be directly related to their ecological role in the soil. We propose a new and relatively simple ecotoxicity test based on the estimation of cast production (CP) by Lumbricus terrestris under laboratory conditions. CP was found to be linearly correlated to earthworm biomass and to be greatly influenced by soil water content. Azinphos-methyl had no effect on CP at all the concentrations tested. Significant decreases were observed at the normal application rate for other pesticides with (imidacloprid, carbaryl, methomyl) or without (ethyl-parathion and chlorpyrifos-ethyl) a clear concentration-effect response. For the highest concentration tested, reduction in CP varied between 35 and 67%. CP is straightforward and rapidly measured and ecologically meaningful. We thus believe it to be of great use as an endpoint in ecotoxicity testing. - Cast production of Lumbricus terrestris is affected by pesticides under laboratory conditions.

  4. 41 CFR 105-69.205 - Professional and technical services.

    Science.gov (United States)

    2010-07-01

    ... any professional or technical discipline. For example, drafting of a legal document accompanying a bid... technical services. 105-69.205 Section 105-69.205 Public Contracts and Property Management Federal Property... technical services. (a) The prohibition on the use of appropriated funds, in § 105-69.100 (a), does not...

  5. 41 CFR 105-69.300 - Professional and technical services.

    Science.gov (United States)

    2010-07-01

    ... or technical discipline. For example, drafting or a legal document accompanying a bid or proposal by... technical services. 105-69.300 Section 105-69.300 Public Contracts and Property Management Federal Property... and technical services. (a) The prohibition on the use of appropriated funds, in § 105-69.100 (a...

  6. 5 CFR 575.105 - Applicability to employees.

    Science.gov (United States)

    2010-01-01

    ... INCENTIVES Recruitment Incentives § 575.105 Applicability to employees. (a) A recruitment incentive may be... offer a recruitment incentive to newly-appointed employees on a group basis. (c) An agency may not... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Applicability to employees. 575.105...

  7. Diagnostic tests for Helicobacter pylori : A prospective evaluation of their accuracy, without selecting a single test as the gold standard

    NARCIS (Netherlands)

    Thijs, J C; van Zwet, A A; Thijs, W J; Oey, H B; Karrenbeld, A; Stellaard, F; Luijt, D S; Meyer, B C; Kleibeuker, J H

    1996-01-01

    OBJECTIVE: To assess the accuracy of six commonly used diagnostic tests for Helicobacter pylori in a prospective study without using any specific test as the gold standard (the patient was regarded as H. pylori-infected if two or more tests, whatever their nature, were positive). METHODS: In 105

  8. 40 CFR 89.105 - Certificate of conformity.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 20 2010-07-01 2010-07-01 false Certificate of conformity. 89.105... and Certification Provisions § 89.105 Certificate of conformity. Every manufacturer of a new nonroad compression-ignition engine must obtain a certificate of conformity covering the engine family, as described...

  9. 105-C Building characterization survey data report

    International Nuclear Information System (INIS)

    Miller, R.L.

    1997-01-01

    This report is a compilation of the 105-C Facility Characterization Survey data collected during the period of July 1, 1994, through September 30, 1994. The scope of the report is limited to the characterization of the 105-C Facility and surrounding site. Conclusions and recommendations regarding courses of future action are beyond the scope of this report. The survey data in this report reflects the current conditions and status of the 105-C Building, and is intended to be used in support of future decontamination and decommissioning activities. The survey was organized and implemented to evaluate the four parameters relating to the current condition of the facility. These parameters concern the physical conditions of the 105-C Building from a personnel safety standpoint; the radiological status throughout the building; identification of the hazardous materials located in the building; and identification of subsurface obstacles left in the path of proposed excavations

  10. 29 CFR 541.105 - Particular weight.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Particular weight. 541.105 Section 541.105 Labor Regulations Relating to Labor (Continued) WAGE AND HOUR DIVISION, DEPARTMENT OF LABOR REGULATIONS DEFINING AND DELIMITING THE EXEMPTIONS FOR EXECUTIVE, ADMINISTRATIVE, PROFESSIONAL, COMPUTER AND OUTSIDE SALES EMPLOYEES...

  11. 41 CFR 105-74.301 - [Reserved

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false [Reserved] 105-74.301 Section 105-74.301 Public Contracts and Property Management Federal Property Management Regulations System...-GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Requirements for Recipients Who Are...

  12. 48 CFR 48.105 - Relationship to other incentives.

    Science.gov (United States)

    2010-10-01

    ... incentives. 48.105 Section 48.105 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION CONTRACT MANAGEMENT VALUE ENGINEERING Policies and Procedures 48.105 Relationship to other incentives... should not be rewarded both as value engineering shares and under performance, design-to-cost, or similar...

  13. 7 CFR 43.105 - Operating characteristics (OC) curves.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 2 2010-01-01 2010-01-01 false Operating characteristics (OC) curves. 43.105 Section 43.105 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE... CONTAINER REGULATIONS STANDARDS FOR SAMPLING PLANS Sampling Plans § 43.105 Operating characteristics (OC...

  14. 33 CFR 105.145 - Maritime Security (MARSEC) Directive.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Maritime Security (MARSEC) Directive. 105.145 Section 105.145 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY MARITIME SECURITY MARITIME SECURITY: FACILITIES General § 105.145 Maritime Security (MARSEC...

  15. 5 CFR 2610.105 - Eligibility of applicants.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Eligibility of applicants. 2610.105 Section 2610.105 Administrative Personnel OFFICE OF GOVERNMENT ETHICS ORGANIZATION AND PROCEDURES... cooperative association as defined in section 15(a) of the Agricultural Marketing Act, 12 U.S.C. 1141j(a...

  16. 41 CFR 105-70.021 - Discovery.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Discovery. 105-70.021 Section 105-70.021 Public Contracts and Property Management Federal Property Management Regulations System..., papers, and other data and documentary evidence. Nothing contained herein shall be interpreted to require...

  17. 42 CFR 93.105 - Time limitations.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Time limitations. 93.105 Section 93.105 Public Health PUBLIC HEALTH SERVICE, DEPARTMENT OF HEALTH AND HUMAN SERVICES HEALTH ASSESSMENTS AND HEALTH EFFECTS STUDIES OF HAZARDOUS SUBSTANCES RELEASES AND FACILITIES PUBLIC HEALTH SERVICE POLICIES ON RESEARCH...

  18. 48 CFR 501.105-1 - Publication and code arrangement.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Publication and code arrangement. 501.105-1 Section 501.105-1 Federal Acquisition Regulations System GENERAL SERVICES... 501.105-1 Publication and code arrangement. The GSAR is published in the following sources: (a) Daily...

  19. 41 CFR 105-74.625 - Criminal drug statute.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Criminal drug statute. 105-74.625 Section 105-74.625 Public Contracts and Property Management Federal Property Management... Administration 74-GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 105-74...

  20. 41 CFR 105-74.635 - Drug-free workplace.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Drug-free workplace. 105-74.635 Section 105-74.635 Public Contracts and Property Management Federal Property Management... Administration 74-GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 105-74...

  1. 41 CFR 105-68.920 - Civil judgment.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Civil judgment. 105-68... Administration 68-GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) Definitions § 105-68.920 Civil judgment. Civil judgment means the disposition of a civil action by any court of competent jurisdiction...

  2. 28 CFR 34.105 - Peer review methods.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Peer review methods. 34.105 Section 34... Review § 34.105 Peer review methods. (a) For both competitive and noncompetitive applications, peer... announcement or otherwise established by the Administrator, together with the assignment of numerical values...

  3. 41 CFR 105-60.608 - Fees, expenses, and costs.

    Science.gov (United States)

    2010-07-01

    ... Demands in Judicial or Administrative Proceedings § 105-60.608 Fees, expenses, and costs. (a) In... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Fees, expenses, and costs. 105-60.608 Section 105-60.608 Public Contracts and Property Management Federal Property...

  4. 48 CFR 3001.105-1 - Publication and code arrangement.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 7 2010-10-01 2010-10-01 false Publication and code arrangement. 3001.105-1 Section 3001.105-1 Federal Acquisition Regulations System DEPARTMENT OF HOMELAND... Purpose, Authority, Issuance 3001.105-1 Publication and code arrangement. (a) The HSAR is published in: (1...

  5. 41 CFR 105-71.141 - Financial reporting.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Financial reporting. 105... GOVERNMENTS 71.14-Post-Award Requirements/Reports, Records, Retention, and Enforcement § 105-71.141 Financial reporting. (a) General. (1) Except as provided in paragraphs (a) (2) and (5) of this section, grantees will...

  6. 77 FR 5275 - Used Electronic Products: An Examination of U.S. Exports; Institution of Investigation and...

    Science.gov (United States)

    2012-02-02

    ... INTERNATIONAL TRADE COMMISSION [Investigation No. 332-528] Used Electronic Products: An... itself, and (4) disposed of by the exporter itself; and The factors affecting trade in used electronic... International Trade Commission. ACTION: Institution of investigation and scheduling of public hearing. SUMMARY...

  7. 41 CFR 105-56.031 - Notice.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Notice. 105-56.031 Section 105-56.031 Public Contracts and Property Management Federal Property Management Regulations System... the amount of offset taken; (ii) The identity of the creditor agency identified by the disbursing...

  8. 41 CFR 105-1.109-52 - Cross-references.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Cross-references. 105-1.109-52 Section 105-1.109-52 Public Contracts and Property Management Federal Property Management Regulations System (Continued) GENERAL SERVICES ADMINISTRATION 1-INTRODUCTION 1.1-Regulations System § 105-1...

  9. 48 CFR 570.105-1 - Contracting by negotiation.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Contracting by negotiation. 570.105-1 Section 570.105-1 Federal Acquisition Regulations System GENERAL SERVICES ADMINISTRATION SPECIAL CONTRACTING PROGRAMS ACQUIRING LEASEHOLD INTERESTS IN REAL PROPERTY General 570.105-1 Contracting by negotiation. Contracting by negotiation...

  10. 41 CFR 105-1.100 - Scope of subpart.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Scope of subpart. 105-1.100 Section 105-1.100 Public Contracts and Property Management Federal Property Management Regulations System (Continued) GENERAL SERVICES ADMINISTRATION 1-INTRODUCTION 1.1-Regulations System § 105-1.100...

  11. 41 CFR 128-1.105 - Authority for JPMR.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Authority for JPMR. 128-1.105 Section 128-1.105 Public Contracts and Property Management Federal Property Management Regulations System (Continued) DEPARTMENT OF JUSTICE 1-INTRODUCTION 1.1-Regulation System § 128-1.105...

  12. 41 CFR 105-1.109-50 - General plan.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false General plan. 105-1.109-50 Section 105-1.109-50 Public Contracts and Property Management Federal Property Management....109-50 General plan. Chapter 105 is divided into parts, subparts, and further subdivisions as...

  13. 41 CFR 105-56.008 - Pre-offset paper hearing.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Pre-offset paper hearing. 105-56.008 Section 105-56.008 Public Contracts and Property Management Federal Property Management... General Services Administration Employees § 105-56.008 Pre-offset paper hearing. If a hearing is to be...

  14. 37 CFR 1.105 - Requirements for information.

    Science.gov (United States)

    2010-07-01

    .... 1.105 Section 1.105 Patents, Trademarks, and Copyrights UNITED STATES PATENT AND TRADEMARK OFFICE... literature, published application, or patent (U.S. or foreign), by any of the inventors, that relates to the claimed invention. (iv) Information used to draft application: A copy of any non-patent literature...

  15. Relevance of microbial finished product testing in food safety management

    DEFF Research Database (Denmark)

    Zwietering, Marcel H.; Jacxsens, Liesbeth; Membré, Jeanne Marie

    2016-01-01

    Management of microbiological food safety is largely based on good design of processes, products and procedures. Finished product testing may be considered as a control measure at the end of the production process. However, testing gives only very limited information on the safety status of a food......-active way by implementing an effective food safety management system. For verification activities in a food safety management system, finished product testing may however be useful. For three cases studies; canned food, chocolate and cooked ham, the relevance of testing both of finished products....... If a hazardous organism is found it means something, but absence in a limited number of samples is no guarantee of safety of a whole production batch. Finished product testing is often too little and too late. Therefore most attention should be focussed on management and control of the hazards in a more pro...

  16. 31 CFR 0.105 - Deputy Ethics Official.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Deputy Ethics Official. 0.105 Section... EMPLOYEE RULES OF CONDUCT General Provisions Responsibilities § 0.105 Deputy Ethics Official. The Chief Counsel or Legal Counsel for a bureau, or a designee, is the Deputy Ethics Official for that bureau. The...

  17. 41 CFR 105-72.602 - Financial reporting.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Financial reporting. 105... § 105-72.602 Financial reporting. (a) The following forms or such other forms as may be approved by OMB are authorized for obtaining financial information from recipients. (1) SF-269 or SF-269A, Financial...

  18. 41 CFR 105-56.021 - Notice.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Notice. 105-56.021 Section 105-56.021 Public Contracts and Property Management Federal Property Management Regulations System... description of the payment and the amount of offset taken; (ii) The identity of GSA as the creditor agency...

  19. 41 CFR 105-71.144 - Termination for convenience.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Termination for convenience. 105-71.144 Section 105-71.144 Public Contracts and Property Management Federal Property... Termination for convenience. Except as provided in § 105-71.143 awards may be terminated in whole or in part...

  20. 22 CFR 1203.735-105 - Disciplinary action.

    Science.gov (United States)

    2010-04-01

    ... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Disciplinary action. 1203.735-105 Section 1203... RESPONSIBILITIES AND CONDUCT General Provisions § 1203.735-105 Disciplinary action. A violation of the regulations in this part by an employee or special Government employee may be cause for appropriate disciplinary...

  1. 41 CFR 105-72.304 - Program income.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Program income. 105-72... Management § 105-72.304 Program income. (a) Federal awarding agencies shall apply the standards set forth in this section in requiring recipient organizations to account for program income related to projects...

  2. 41 CFR 105-71.125 - Program income.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Program income. 105-71... GOVERNMENTS 71.12-Post-Award Requirements/Financial Administration § 105-71.125 Program income. (a) General. Grantees are encouraged to earn income to defray program costs. Program income includes income from fees...

  3. 18 CFR 2.105 - Gas supply charges.

    Science.gov (United States)

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false Gas supply charges. 2.105 Section 2.105 Conservation of Power and Water Resources FEDERAL ENERGY REGULATORY COMMISSION... prior to nominations by the customers a firm price or pricing formula for the service, and hold that...

  4. 77 FR 29360 - Used Electronic Products: An Examination of U.S. Exports Submission of Questionnaire for OMB Review

    Science.gov (United States)

    2012-05-17

    ... INTERNATIONAL TRADE COMMISSION [INVESTIGATION NO. 332-528] Used Electronic Products: An... Trade Commission. ACTION: In accordance with the provisions of the Paperwork Reduction Act of 1995 (44 U.S.C. Chapter 35), the U.S. International Trade Commission (Commission) has submitted a request for...

  5. Toward imaging the body at 10.5 tesla.

    Science.gov (United States)

    Ertürk, M Arcan; Wu, Xiaoping; Eryaman, Yiğitcan; Van de Moortele, Pierre-François; Auerbach, Edward J; Lagore, Russell L; DelaBarre, Lance; Vaughan, J Thomas; Uğurbil, Kâmil; Adriany, Gregor; Metzger, Gregory J

    2017-01-01

    To explore the potential of performing body imaging at 10.5 Tesla (T) compared with 7.0T through evaluating the transmit/receive performance of similarly configured dipole antenna arrays. Fractionated dipole antenna elements for 10.5T body imaging were designed and evaluated using numerical simulations. Transmit performance of antenna arrays inside the prostate, kidneys and heart were investigated and compared with those at 7.0T using both phase-only radiofrequency (RF) shimming and multi-spoke pulses. Signal-to-noise ratio (SNR) comparisons were also performed. A 10-channel antenna array was constructed to image the abdomen of a swine at 10.5T. Numerical methods were validated with phantom studies at both field strengths. Similar power efficiencies were observed inside target organs with phase-only shimming, but RF nonuniformity was significantly higher at 10.5T. Spokes RF pulses allowed similar transmit performance with accompanying local specific absorption rate increases of 25-90% compared with 7.0T. Relative SNR gains inside the target anatomies were calculated to be >two-fold higher at 10.5T, and 2.2-fold SNR gain was measured in a phantom. Gradient echo and fast spin echo imaging demonstrated the feasibility of body imaging at 10.5T with the designed array. While comparable power efficiencies can be achieved using dipole antenna arrays with static shimming at 10.5T; increasing RF nonuniformities underscore the need for efficient, robust, and safe parallel transmission methods. Magn Reson Med 77:434-443, 2017. © 2016 International Society for Magnetic Resonance in Medicine. © 2016 International Society for Magnetic Resonance in Medicine.

  6. The 105 month Swift-BAT data release

    Science.gov (United States)

    Oh, Kyuseok; Koss, Michael; Markwardt, Craig B.; Schawinski, Kevin; Baumgartner, Wayne H.; Barthelmy, Scott D.; Cenko, Bradley; Gehrels, Neil; Mushotzky, Richard; Petulante, Abigail; Ricci, Claudio; Lien, Amy; Trakhtenbrot, Benny; NASA GSFC Swift BAT team, BAT AGN Spectroscopic Survey (BASS)

    2018-01-01

    We present a new catalog of hard X-ray sources detected in the first 105 months of observations with the Burst Alert Telescope (BAT) on board the Swift observatory. The 105 month Swift-BAT survey is a uniform hard X-ray all-sky survey with a sensitivity of 8.40×10-12 erg s-1 cm-2 over 90% of the sky and 7.24×10-12 erg s-1 cm-2 over 50% of the sky in the 14‑195 keV band. The Swift-BAT 105 month catalog provides 1632 (422 new detections) hard X-ray sources in the 14 ‑ 195 keV band above the 4.8σ significance level. Adding to the previously known hard X-ray sources, 34% (144/422) of the new detections are identified as Seyfert AGN in nearby galaxies (z BAT catalog, we release eight-channel spectra and monthly sampled light curves for each object in the online journal and at the Swift-BAT 105 month Web site.

  7. 41 CFR 105-56.018 - Salary offset.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Salary offset. 105-56... Administration 56-SALARY OFFSET FOR INDEBTEDNESS OF FEDERAL EMPLOYEES TO THE UNITED STATES Centralized Salary Offset (CSO) Procedures-GSA as Creditor Agency § 105-56.018 Salary offset. When a match occurs and all...

  8. 41 CFR 105-56.028 - Salary offset.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Salary offset. 105-56... Administration 56-SALARY OFFSET FOR INDEBTEDNESS OF FEDERAL EMPLOYEES TO THE UNITED STATES Centralized Salary Offset (CSO) Procedures-GSA as Paying Agency § 105-56.028 Salary offset. When a match occurs and all...

  9. 14 CFR 105.7 - Use of alcohol and drugs.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 2 2010-01-01 2010-01-01 false Use of alcohol and drugs. 105.7 Section 105...) AIR TRAFFIC AND GENERAL OPERATING RULES PARACHUTE OPERATIONS § 105.7 Use of alcohol and drugs. No... of— (a) Alcohol, or (b) Any drug that affects that person's faculties in any way contrary to safety. ...

  10. Using a fuzzy comprehensive evaluation method to determine product usability: A test case.

    Science.gov (United States)

    Zhou, Ronggang; Chan, Alan H S

    2017-01-01

    In order to take into account the inherent uncertainties during product usability evaluation, Zhou and Chan [1] proposed a comprehensive method of usability evaluation for products by combining the analytic hierarchy process (AHP) and fuzzy evaluation methods for synthesizing performance data and subjective response data. This method was designed to provide an integrated framework combining the inevitable vague judgments from the multiple stages of the product evaluation process. In order to illustrate the effectiveness of the model, this study used a summative usability test case to assess the application and strength of the general fuzzy usability framework. To test the proposed fuzzy usability evaluation framework [1], a standard summative usability test was conducted to benchmark the overall usability of a specific network management software. Based on the test data, the fuzzy method was applied to incorporate both the usability scores and uncertainties involved in the multiple components of the evaluation. Then, with Monte Carlo simulation procedures, confidence intervals were used to compare the reliabilities among the fuzzy approach and two typical conventional methods combining metrics based on percentages. This case study showed that the fuzzy evaluation technique can be applied successfully for combining summative usability testing data to achieve an overall usability quality for the network software evaluated. Greater differences of confidence interval widths between the method of averaging equally percentage and weighted evaluation method, including the method of weighted percentage averages, verified the strength of the fuzzy method.

  11. 41 CFR 105-8.150-2 - Methods.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Methods. 105-8.150-2... HANDICAP IN PROGRAMS OR ACTIVITIES CONDUCTED BY GENERAL SERVICES ADMINISTRATION § 105-8.150-2 Methods. (a... construction of new facilities, use of accessible rolling stock, or any other methods that result in making its...

  12. Scaling net ecosystem production and net biome production over a heterogeneous region in the Western United States

    Science.gov (United States)

    D.P. Turner; W.D. Ritts; B.E. Law; W.B. Cohen; Z. Yan; T. Hudiburg; J.L. Campbell; M. Duane

    2007-01-01

    Bottom-up scaling of net ecosystem production (NEP) and net biome production (NBP) was used to generate a carbon budget for a large heterogeneous region (the state of Oregon, 2.5x105 km2 ) in the Western United States. Landsat resolution (30 m) remote sensing provided the basis for mapping land cover and disturbance history...

  13. Optimal number of tests to achieve and validate product reliability

    International Nuclear Information System (INIS)

    Ahmed, Hussam; Chateauneuf, Alaa

    2014-01-01

    The reliability validation of engineering products and systems is mandatory for choosing the best cost-effective design among a series of alternatives. Decisions at early design stages have a large effect on the overall life cycle performance and cost of products. In this paper, an optimization-based formulation is proposed by coupling the costs of product design and validation testing, in order to ensure the product reliability with the minimum number of tests. This formulation addresses the question about the number of tests to be specified through reliability demonstration necessary to validate the product under appropriate confidence level. The proposed formulation takes into account the product cost, the failure cost and the testing cost. The optimization problem can be considered as a decision making system according to the hierarchy of structural reliability measures. The numerical examples show the interest of coupling design and testing parameters. - Highlights: • Coupled formulation for design and testing costs, with lifetime degradation. • Cost-effective testing optimization to achieve reliability target. • Solution procedure for nested aleatoric and epistemic variable spaces

  14. Positron emission tomography imaging of CD105 expression during tumor angiogenesis

    Energy Technology Data Exchange (ETDEWEB)

    Hong, Hao [University of Wisconsin - Madison, Department of Radiology, Madison, WI (United States); Yang, Yunan [University of Wisconsin - Madison, Department of Radiology, Madison, WI (United States); Third Military Medical University, Department of Ultrasound, Xinqiao Hospital, Chongqing (China); Zhang, Yin; Engle, Jonathan W.; Barnhart, Todd E.; Nickles, Robert J. [University of Wisconsin - Madison, Department of Medical Physics, Madison, WI (United States); Leigh, Bryan R. [TRACON Pharmaceuticals, Inc., San Diego, CA (United States); Cai, Weibo [University of Wisconsin - Madison, Department of Radiology, Madison, WI (United States); University of Wisconsin - Madison, Department of Medical Physics, Madison, WI (United States); University of Wisconsin Carbone Cancer Center, Madison, WI (United States); University of Wisconsin - Madison, Departments of Radiology and Medical Physics, School of Medicine and Public Health, Madison, WI (United States)

    2011-07-15

    Overexpression of CD105 (endoglin) correlates with poor prognosis in many solid tumor types. Tumor microvessel density (MVD) assessed by CD105 staining is the current gold standard for evaluating tumor angiogenesis in the clinic. The goal of this study was to develop a positron emission tomography (PET) tracer for imaging CD105 expression. TRC105, a chimeric anti-CD105 monoclonal antibody, was conjugated to 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) and labeled with {sup 64}Cu. FACS analysis and microscopy studies were performed to compare the CD105 binding affinity of TRC105 and DOTA-TRC105. PET imaging, biodistribution, blocking, and ex vivo histology studies were performed on 4T1 murine breast tumor-bearing mice to evaluate the ability of {sup 64}Cu-DOTA-TRC105 to target tumor angiogenesis. Another chimeric antibody, cetuximab, was used as an isotype-matched control. FACS analysis of human umbilical vein endothelial cells (HUVECs) revealed no difference in CD105 binding affinity between TRC105 and DOTA-TRC105, which was further validated by fluorescence microscopy. {sup 64}Cu labeling was achieved with high yield and specific activity. Serial PET imaging revealed that the 4T1 tumor uptake of the tracer was 8.0 {+-} 0.5, 10.4 {+-} 2.8, and 9.7 {+-} 1.8%ID/g at 4, 24, and 48 h post-injection, respectively (n = 3), higher than most organs at late time points which provided excellent tumor contrast. Biodistribution data as measured by gamma counting were consistent with the PET findings. Blocking experiments, control studies with {sup 64}Cu-DOTA-cetuximab, as well as ex vivo histology all confirmed the in vivo target specificity of {sup 64}Cu-DOTA-TRC105. This is the first successful PET imaging study of CD105 expression. Fast, prominent, persistent, and CD105-specific uptake of the tracer in the 4T1 tumor was observed. Further studies are warranted and currently underway. (orig.)

  15. 42 CFR 402.105 - Amount of penalty.

    Science.gov (United States)

    2010-10-01

    ... insurance benefit plans (§ 402.1(c)(21)). (b) $1,000. CMS or OIG may impose a penalty of not more than $1... 42 Public Health 2 2010-10-01 2010-10-01 false Amount of penalty. 402.105 Section 402.105 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL...

  16. 46 CFR 105.35-15 - Fire hose.

    Science.gov (United States)

    2010-10-01

    ... bronze or equivalent metal. (e) All fittings on fire hose shall be of brass, copper, or other suitable corrosion resistant metal. (f) A length of fire hose shall be attached to each fire hydrant at all times... 46 Shipping 4 2010-10-01 2010-10-01 false Fire hose. 105.35-15 Section 105.35-15 Shipping COAST...

  17. 46 CFR 57.06-3 - Method of performing production testing.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 2 2010-10-01 2010-10-01 false Method of performing production testing. 57.06-3 Section 57.06-3 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING WELDING AND BRAZING Production Tests § 57.06-3 Method of performing production testing. (a) Except as...

  18. 47 CFR 101.105 - Interference protection criteria.

    Science.gov (United States)

    2010-10-01

    ... 47 Telecommunication 5 2010-10-01 2010-10-01 false Interference protection criteria. 101.105 Section 101.105 Telecommunication FEDERAL COMMUNICATIONS COMMISSION (CONTINUED) SAFETY AND SPECIAL RADIO.... (ii) To accommodate co-primary Direct Broadcast Satellite Service earth stations, an MVDDS...

  19. 14 CFR 152.105 - Sponsors and planning agencies: Airport planning.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Sponsors and planning agencies: Airport planning. 152.105 Section 152.105 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF....105 Sponsors and planning agencies: Airport planning. (a) To be eligible to apply for a project for...

  20. PHEBUS on-line aerosol monitor development test program

    International Nuclear Information System (INIS)

    Sprenger, M.H.; Pentecost, C.G.

    1992-03-01

    EG ampersand G Idaho, Inc. developed an on-line aerosol monitor (OLAM) for the French PHEBUS Fission Product Project. Part of the development was to manufacture and test an OLAM prototype. This report presents the results of the testing which determined the mechanical integrity of the monitor at operating temperature and pressure and performed a preliminary test of the optical system. A series of twenty different tests was conducted during the prototype testing sequence. Since no leaks were detected, the OLAM demonstrated that it could provide a pressure boundary at required test conditions. The optical and electrical system also proved its integrity by exceeding the design requirement of less than 105 optical signal drift during an actual two-hour test sequence

  1. 40 CFR 133.105 - Treatment equivalent to secondary treatment.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 21 2010-07-01 2010-07-01 false Treatment equivalent to secondary treatment. 133.105 Section 133.105 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) WATER PROGRAMS SECONDARY TREATMENT REGULATION § 133.105 Treatment equivalent to secondary treatment...

  2. EFFECT OF GREEN BUSINESS PRACTICES ON ...

    African Journals Online (AJOL)

    DGS-FUTO

    2018-06-01

    Jun 1, 2018 ... checked for reliability using test re-test method through Cronbach alpha, ... natural resources, less energy, and less water which will lead to .... method, technological development product/services distribution system, or even a new ..... Out of the 543 copies of questionnaire distributed, 528 were returned.

  3. A data base and a standard material for use in acceptance testing of low-activity waste products

    International Nuclear Information System (INIS)

    Wolf, S.F.; Ebert, W.L.; Luo, J.S.; Strachan, D.M.

    1998-04-01

    The authors have conducted replicate dissolution tests following the product consistency test (PCT) procedure to measure the mean and standard deviation of the solution concentrations of B, Na, and Si at various combinations of temperature, duration, and glass/water mass ratio. Tests were conducted with a glass formulated to be compositionally similar to low-activity waste products anticipated for Hanford to evaluate the adequacy of test methods that have been designated in privatization contracts for use in product acceptance. An important finding from this set of tests is that the solution concentrations generated in tests at 20 C will likely be too low to measure the dissolution rates of waste products reliably. Based on these results, the authors recommend that the acceptance test be conducted at 40 C. Tests at 40 C generated higher solution concentrations, were more easily conducted, and the measured rates were easily related to those at 20 C. Replicate measurements of other glass properties were made to evaluate the possible use of LRM-1 as a standard material. These include its composition, homogeneity, density, compressive strength, the Na leachability index with the ANSI/ANS 16.1 leach test, and if the glass is characteristically hazardous with the toxicity characteristic leach procedure. The values of these properties were within the acceptable limits identified for Hanford low-activity waste products. The reproducibility of replicate tests and analyses indicates that the glass would be a suitable standard material

  4. Heavy fragment production cross sections from 1.05 GeV/nucleon 56Fe in C, Al, Cu, Pb, and CH2 targets

    Science.gov (United States)

    Zeitlin, C.; Heilbronn, L.; Miller, J.; Rademacher, S. E.; Borak, T.; Carter, T. R.; Frankel, K. A.; Schimmerling, W.; Stronach, C. E.; Chatterjee, A. (Principal Investigator)

    1997-01-01

    We have obtained charge-changing cross sections and partial cross sections for fragmentation of 1.05 GeV/nucleon Fe projectiles incident on H, C, Al, Cu, and Pb nuclei. The energy region covered by this experiment is critical for an understanding of galactic cosmic ray propagation and space radiation biophysics. Surviving primary beam particles and fragments with charges from 12 to 25 produced within a forward cone of half-angle 61 mrad were detected using a silicon detector telescope to identify their charge and the cross sections were calculated after correction of the measured yields for finite target thickness effects. The cross sections are compared to model calculations and to previous measurements. Cross sections for the production of fragments with even-numbered nuclear charges are seen to be enhanced in almost all cases.

  5. 48 CFR 1.105-1 - Publication and code arrangement.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Publication and code arrangement. 1.105-1 Section 1.105-1 Federal Acquisition Regulations System FEDERAL ACQUISITION REGULATION GENERAL FEDERAL ACQUISITION REGULATIONS SYSTEM Purpose, Authority, Issuance 1.105-1 Publication and code...

  6. 48 CFR 401.105-1 - Publication and code arrangement.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Publication and code arrangement. 401.105-1 Section 401.105-1 Federal Acquisition Regulations System DEPARTMENT OF AGRICULTURE GENERAL AGRICULTURE ACQUISITION REGULATION SYSTEM Purpose, Authority, Issuance 401.105-1 Publication and...

  7. Collider Dipole Magnet test program from development through production

    International Nuclear Information System (INIS)

    Bailey, R.E.

    1991-01-01

    Verification of CDM performance, reliability, and magnet production processes will be accomplished during the development phase of the program. Key features of this program include thorough in process testing of magnet subassemblies, verification of the magnetic field quality, and demonstration of the CDM performance during the formal qualification program. Reliability demonstration of the CDM design includes component tests and an accelerated life test program. Prototype magnet phase will address achievement of magnet performance goals through a program of fabrications, test, analysis, redesign as required and procurement of modified parts for a second fabrication run. This process would be repeated again if necessary, and would conclude with a final design for the production magnets. Production process validation will address the effects that key production processes have upon magnet performance, using the magnets produced during the Preproduction phase

  8. 49 CFR 212.105 - Agreements.

    Science.gov (United States)

    2010-10-01

    ... TRANSPORTATION STATE SAFETY PARTICIPATION REGULATIONS State/Federal Roles § 212.105 Agreements. (a) Scope. The... facilities, equipment, and operating practices through planned routine compliance inspections for all, or a...

  9. Energy of a shock wave generated in different metals under irradiation by a high-power laser pulse

    Czech Academy of Sciences Publication Activity Database

    Gus'kov, S. Yu.; Kasperczuk, A.; Pisarczyk, T.; Borodziuk, S.; Ullschmied, Jiří; Krouský, Eduard; Mašek, Karel; Pfeifer, Miroslav; Skála, Jiří; Pisarczyk, P.

    2007-01-01

    Roč. 105, č. 4 (2007), s. 793-802 ISSN 1063-7761 R&D Projects: GA MŠk(CZ) LC528 Grant - others:HPC Europa(XE) RII3-CT-2003-506350 Program:FP6 Institutional research plan: CEZ:AV0Z20430508; CEZ:AV0Z10100523 Source of funding: R - rámcový projekt EK Keywords : shock waves * laser radiation * laser plasma * inertial confinement * PALS laser Subject RIV: BL - Plasma and Gas Discharge Physics Impact factor: 1.075, year: 2007

  10. Performance test results of mock-up model test facility with a full-scale reaction tube for HTTR hydrogen production system. Contract research

    Energy Technology Data Exchange (ETDEWEB)

    Inagaki, Yoshiyuki; Hayashi, Koji; Kato, Michio [Japan Atomic Energy Research Inst., Oarai, Ibaraki (Japan). Oarai Research Establishment] [and others

    2003-03-01

    Research on a hydrogen production system by steam reforming of methane, chemical reaction; CH{sub 4} + H{sub 2}O {yields} 3H{sub 2}O + CO, has been carried out to couple with the HTTR for establishment of high-temperature nuclear heat utilization technology and contribution to hydrogen energy society in future. The mock-up test facility with a full-scale reaction tube test facility, a model simulating one reaction tube of a steam reformer of the HTTR hydrogen production system in full scale, was fabricated to perform tests on controllability, hydrogen production performance etc. under the same pressure and temperature conditions as those of the HTTR hydrogen production system. The design and fabrication of the test facility started from 1997, and the all components were installed until September in 2001. In a performance test conducted from October in 2001 to February in 2002, performance of each component was examined and hydrogen of 120m{sup 3}{sub N}/h was successfully produced with high-temperature helium gas. This report describes the performance test results on components performance, hydrogen production characteristics etc., and main troubles and countermeasures. (author)

  11. Performance test results of mock-up model test facility with a full-scale reaction tube for HTTR hydrogen production system. Contract research

    International Nuclear Information System (INIS)

    Inagaki, Yoshiyuki; Hayashi, Koji; Kato, Michio

    2003-03-01

    Research on a hydrogen production system by steam reforming of methane, chemical reaction; CH 4 + H 2 O → 3H 2 O + CO, has been carried out to couple with the HTTR for establishment of high-temperature nuclear heat utilization technology and contribution to hydrogen energy society in future. The mock-up test facility with a full-scale reaction tube test facility, a model simulating one reaction tube of a steam reformer of the HTTR hydrogen production system in full scale, was fabricated to perform tests on controllability, hydrogen production performance etc. under the same pressure and temperature conditions as those of the HTTR hydrogen production system. The design and fabrication of the test facility started from 1997, and the all components were installed until September in 2001. In a performance test conducted from October in 2001 to February in 2002, performance of each component was examined and hydrogen of 120m 3 N /h was successfully produced with high-temperature helium gas. This report describes the performance test results on components performance, hydrogen production characteristics etc., and main troubles and countermeasures. (author)

  12. 41 CFR 105-72.307 - Allowable costs.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Allowable costs. 105-72.307 Section 105-72.307 Public Contracts and Property Management Federal Property Management... Administration 72-UNIFORM ADMINISTRATIVE REQUIREMENTS FOR GRANTS AND AGREEMENTS WITH INSTITUTIONS OF HIGHER...

  13. 41 CFR 105-72.204 - Special award conditions.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Special award conditions. 105-72.204 Section 105-72.204 Public Contracts and Property Management Federal Property Management... award conditions. If an applicant or recipient: (a) Has a history of poor performance, (b) Is not...

  14. 41 CFR 105-74.645 - Federal agency or agency.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Federal agency or agency. 105-74.645 Section 105-74.645 Public Contracts and Property Management Federal Property Management... Administration 74-GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Definitions § 105-74...

  15. 41 CFR 105-72.504 - Procurement procedures.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Procurement procedures. 105-72.504 Section 105-72.504 Public Contracts and Property Management Federal Property Management... acceptable characteristics or minimum acceptable standards. (iv) The specific features of “brand name or...

  16. 33 CFR 105.290 - Additional requirements-cruise ship terminals.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Additional requirements-cruise ship terminals. 105.290 Section 105.290 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY MARITIME SECURITY MARITIME SECURITY: FACILITIES Facility Security Requirements § 105.290 Additional requirements—cruise ship terminals...

  17. 13 CFR 105.402 - Standards of Conduct Counselors.

    Science.gov (United States)

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Standards of Conduct Counselors. 105.402 Section 105.402 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION STANDARDS OF... Conduct Counselors. (a) The SBA Standards of Conduct Counselor is the Designated Agency Ethics Official...

  18. 41 CFR 105-70.041 - Stay pending appeal.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Stay pending appeal. 105... Administration 70-IMPLEMENTATION OF THE PROGRAM FRAUD CIVIL REMEDIES ACT OF 1986 § 105-70.041 Stay pending appeal. (a) An initial decision is stayed automatically pending disposition of a motion for reconsideration...

  19. 41 CFR 105-64.106 - What is GSA's policy on information accuracy in a system of records?

    Science.gov (United States)

    2010-07-01

    ... information accuracy in a system of records? 105-64.106 Section 105-64.106 Public Contracts and Property Management Federal Property Management Regulations System (Continued) GENERAL SERVICES ADMINISTRATION... Responsibilities § 105-64.106 What is GSA's policy on information accuracy in a system of records? System managers...

  20. Methodological issues in testing the marginal productivity theory

    NARCIS (Netherlands)

    P.T. Gottschalk (Peter); J. Tinbergen (Jan)

    1982-01-01

    textabstractPrevious tests of the marginal productivity theory have been criticized on several grounds reviewed by the authors. One important deficiency has been the small number of factor inputs entered in the production functions. In 1978 Gottschalk suggested a method to estimate production

  1. 41 CFR 105-1.000-50 - Scope of part.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Scope of part. 105-1.000-50 Section 105-1.000-50 Public Contracts and Property Management Federal Property Management Regulations System (Continued) GENERAL SERVICES ADMINISTRATION 1-INTRODUCTION § 105-1.000-50 Scope of part...

  2. 41 CFR 105-70.019 - Prehearing conferences.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Prehearing conferences. 105-70.019 Section 105-70.019 Public Contracts and Property Management Federal Property Management... party chooses to waive appearance at an oral hearing and to submit only documentary evidence (subject to...

  3. 24 CFR 904.105 - Counseling of homebuyers.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Counseling of homebuyers. 904.105... DEVELOPMENT LOW RENT HOUSING HOMEOWNERSHIP OPPORTUNITIES Turnkey III Program Description § 904.105 Counseling of homebuyers. The LHA shall provide counseling and training as provided in subpart C of this part...

  4. 41 CFR 105-60.305-1 - Definitions.

    Science.gov (United States)

    2010-07-01

    ... to the public and to private sector organizations; (2) Ensure that groups and individuals pay the... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Definitions. 105-60.305..., Orders, Policies, Interpretations, Manuals, and Instructions § 105-60.305-1 Definitions. For the purpose...

  5. 41 CFR 105-1.104 - Publication of GSPMR.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Publication of GSPMR. 105-1.104 Section 105-1.104 Public Contracts and Property Management Federal Property Management....104 Publication of GSPMR. (a) Most GSPMR are published in the Federal Register. This practice helps to...

  6. Relevance of microbial finished product testing in food safety management

    NARCIS (Netherlands)

    Zwietering, M.H.; Jacxsens, L.; Membre, J.M.; Nauta, M.; Peterz, M.

    2016-01-01

    Management of microbiological food safety is largely based on good design of processes, products and procedures. Finished product testing may be considered as a control measure at the end of the production process. However, testing gives only very limited information on the safety status of a food.

  7. 41 CFR 102-117.105 - What does best value mean when routing a shipment?

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What does best value mean when routing a shipment? 102-117.105 Section 102-117.105 Public Contracts and Property Management... 117-TRANSPORTATION MANAGEMENT Business Rules To Consider Before Shipping Freight or Household Goods...

  8. Empirical testing of forecast update procedure forseasonal products

    DEFF Research Database (Denmark)

    Wong, Chee Yew; Johansen, John

    2008-01-01

    Updating of forecasts is essential for successful collaborative forecasting, especially for seasonal products. This paper discusses the results of a theoretical simulation and an empirical test of a proposed time-series forecast updating procedure. It involves a two-stage longitudinal case study...... of a toy supply chain. The theoretical simulation involves historical weekly consumer demand data for 122 toy products. The empirical test is then carried out in real-time with 291 toy products. The results show that the proposed forecast updating procedure: 1) reduced forecast errors of the annual...... provided less forecast accuracy improvement and it needed a longer time to achieve relatively acceptable forecast uncertainty....

  9. Major advances in testing of dairy products: milk component and dairy product attribute testing.

    Science.gov (United States)

    Barbano, D M; Lynch, J M

    2006-04-01

    Milk component analysis is relatively unusual in the field of quantitative analytical chemistry because an analytical test result determines the allocation of very large amounts of money between buyers and sellers of milk. Therefore, there is high incentive to develop and refine these methods to achieve a level of analytical performance rarely demanded of most methods or laboratory staff working in analytical chemistry. In the last 25 yr, well-defined statistical methods to characterize and validate analytical method performance combined with significant improvements in both the chemical and instrumental methods have allowed achievement of improved analytical performance for payment testing. A shift from marketing commodity dairy products to the development, manufacture, and marketing of value added dairy foods for specific market segments has created a need for instrumental and sensory approaches and quantitative data to support product development and marketing. Bringing together sensory data from quantitative descriptive analysis and analytical data from gas chromatography olfactometry for identification of odor-active compounds in complex natural dairy foods has enabled the sensory scientist and analytical chemist to work together to improve the consistency and quality of dairy food flavors.

  10. 41 CFR 105-64.105 - When may Social Security Numbers (SSNs) be collected?

    Science.gov (United States)

    2010-07-01

    ...-64.105 When may Social Security Numbers (SSNs) be collected? (a) Statutory or regulatory authority must exist for collecting Social Security Numbers for record systems that use the SSNs as a method of... collect Social Security Numbers. (b) In compliance with OMB M-07-16 (Safeguarding Against and Responding...

  11. Application of response surface methodology for studying the product characteristics of extruded rice-cowpea-groundnut blends.

    Science.gov (United States)

    Asare, Emmanuel Kwasi; Sefa-Dedeh, Samuel; Sakyi-Dawson, Esther; Afoakwa, Emmanuel Ohene

    2004-08-01

    Response surface methodology (with central composite rotatable design for k=3) was used to investigate the product properties of extruded rice-cowpea-groundnut blends in a single screw extruder. The combined effect of cowpea (0-20%), groundnut (0-10%), and feed moisture (14-48%) levels were used for formulation of the products. The product moisture, expansion ratio, bulk density and total colour change were studied using standard analytical methods. Well-expanded rice-legume blend extrudates of less bulk density and lower moisture content were produced at low feed moisture. Increasing legume addition affected the various shades of colour in the product. Models developed for the indices gave R(2) values ranging from 52.8% (for the b-value) to 86.5% (for bulk density). The models developed suggested that the optimal process variables for the production of a puffed snack with an enhanced nutrition and spongy structure from a rice-cowpea-groundnut blend are low feed moisture of 14-20% and maximum additions of 20% cowpea and 10% groundnut. A lack-of-fit test showed no significance, indicating that the models adequately fitted the data.

  12. 48 CFR 2909.105 - Procedures.

    Science.gov (United States)

    2010-10-01

    ... determination of contractor responsibility on a review of the company's “Summary or Financial Report” from Dun...'s responsibility in accordance with FAR 9.105. In addition to past performance information, the...

  13. Central location test vs. home use test: Contrasting results depending on product type

    NARCIS (Netherlands)

    Boutrolle, I.; Delarue, J.; Arranz, D.; Rogeaux, M.; Köster, E.P.

    2007-01-01

    Marketing professionals and sensory scientists have several hedonic testing methods at their disposal to assess product acceptability. The central location test (CLT) which usually takes place in a standardised location under controlled conditions is more frequently used than the home use test

  14. 41 CFR 105-50.001-1 - State.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false State. 105-50.001-1... System (Continued) GENERAL SERVICES ADMINISTRATION 50-PROVISION OF SPECIAL OR TECHNICAL SERVICES TO STATE AND LOCAL UNITS OF GOVERNMENT § 105-50.001-1 State. State means any of the several States of the...

  15. Looks: Studio 54 and the Production of Fabulous Nightlife

    Directory of Open Access Journals (Sweden)

    madison alexander moore

    2013-05-01

    Full Text Available 0 0 1 92 528 yale university 4 1 619 14.0 Normal 0 false false false EN-US JA X-NONE This article combines my experience as a party-host and nightlife-creator with a close reading of Studio 54 as a theatrical production. I call for a consideration of how the staging of nightlife functions as an art form, relying on the dual practices of creation and curation. I provide a close reading of the tightly-staged Studio 54 experience, focusing on the club's infamously tight door policy and production of fabulousness to reveal what scholars and ethnographers of nightlife can learn from approaching nightlife as an artistic production. This approach can also inform a nightlife-focused research agenda.  

  16. Potential Errors and Test Assessment in Software Product Line Engineering

    Directory of Open Access Journals (Sweden)

    Hartmut Lackner

    2015-04-01

    Full Text Available Software product lines (SPL are a method for the development of variant-rich software systems. Compared to non-variable systems, testing SPLs is extensive due to an increasingly amount of possible products. Different approaches exist for testing SPLs, but there is less research for assessing the quality of these tests by means of error detection capability. Such test assessment is based on error injection into correct version of the system under test. However to our knowledge, potential errors in SPL engineering have never been systematically identified before. This article presents an overview over existing paradigms for specifying software product lines and the errors that can occur during the respective specification processes. For assessment of test quality, we leverage mutation testing techniques to SPL engineering and implement the identified errors as mutation operators. This allows us to run existing tests against defective products for the purpose of test assessment. From the results, we draw conclusions about the error-proneness of the surveyed SPL design paradigms and how quality of SPL tests can be improved.

  17. Preliminary Beam Irradiation Test for RI Production Targets at KOMAC

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, Sang Pil; Kwon, Hyeok Jung; Kim, Han Sung; Cho, Yong Sub; Seol, Kyung Tae; Song, Young Gi; Kim, Dae Il; Jung, Myung Hwan; Kim, Kye Ryung; Min, Yi Sub [KAERI, Daejeon (Korea, Republic of)

    2016-05-15

    The new beamline and target irradiation facility has been constructed for the production of therapeutic radio-isotope. Sr-82 and Cu-67 were selected as the target isotope in this facility, they are promising isotope for the PET imaging and cancer therapy. For the facility commissioning, the irradiation test for the prototype-target was conducted to confirm the feasibility of radio-isotope production, the proto-type targets are made of RbCl pellet and the natural Zn metal for Sr-82 and Cu-67 production respectively, In this paper, an introduction to the RI production targetry system and the results of the preliminary beam irradiation test are discussed. the low-flux beam irradiation tests for proto-type RI target have been conducted. As a result of the beam irradiation tests, we could obtain the evidence of Sr-82 and Cu-67 production, have confirmed the feasibility of Sr-82 and Cu-67 production at KOMAC RI production facility.

  18. Preliminary Beam Irradiation Test for RI Production Targets at KOMAC

    International Nuclear Information System (INIS)

    Yoon, Sang Pil; Kwon, Hyeok Jung; Kim, Han Sung; Cho, Yong Sub; Seol, Kyung Tae; Song, Young Gi; Kim, Dae Il; Jung, Myung Hwan; Kim, Kye Ryung; Min, Yi Sub

    2016-01-01

    The new beamline and target irradiation facility has been constructed for the production of therapeutic radio-isotope. Sr-82 and Cu-67 were selected as the target isotope in this facility, they are promising isotope for the PET imaging and cancer therapy. For the facility commissioning, the irradiation test for the prototype-target was conducted to confirm the feasibility of radio-isotope production, the proto-type targets are made of RbCl pellet and the natural Zn metal for Sr-82 and Cu-67 production respectively, In this paper, an introduction to the RI production targetry system and the results of the preliminary beam irradiation test are discussed. the low-flux beam irradiation tests for proto-type RI target have been conducted. As a result of the beam irradiation tests, we could obtain the evidence of Sr-82 and Cu-67 production, have confirmed the feasibility of Sr-82 and Cu-67 production at KOMAC RI production facility

  19. 46 CFR 163.003-27 - Production tests and examination.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 6 2010-10-01 2010-10-01 false Production tests and examination. 163.003-27 Section 163... examination. (a) General. Each ladder produced under Coast Guard approval must be tested in accordance with... for effective monitoring throughout the production schedule. (e) Visual examination. The visual...

  20. 46 CFR 160.017-27 - Production tests and examination.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 6 2010-10-01 2010-10-01 false Production tests and examination. 160.017-27 Section 160... examination. (a) General. Each ladder manufactured under Coast Guard approval must be tested in accordance... for effective monitoring throughout the production schedule. (e) Visual examination. The visual...

  1. Safety Evaluation Report related to the operation of Palo Verde Nuclear Generating Station, Units 1, 2, and 3 (Docket Nos. STN 50-528, STN 50-529, and STN 50-530). Supplement No. 9

    International Nuclear Information System (INIS)

    1985-12-01

    Supplement No. 9 to the Safety Evaluation Report for the application filed by Arizona Public Service Company et al. for licenses to operate the Palo Verde Nuclear Generating Station, Units 1, 2 and 3 (Docket Nos. STN 50-528/529/530), located in Maricopa County, Arizona, has been prepared by the Office of Nuclear Reactor Regulation of the Nuclear Regulatory Commission. The purpose of this supplement is to update the Safety Evaluation Report by providing an evaluation of: (1) additional information submitted by the applicant since Supplement No. 8 was issued; and (2) matters that the staff had under review when Supplement No. 8 was issued, specifically those issues which required resolution prior to Unit 2 fuel loading and testing up to 5% of full power

  2. A product lifecycle management framework to support the exchange of prototyping and testing information

    Science.gov (United States)

    Toche Fumchum, Luc Boris

    2011-12-01

    The modern perspective on product life cycle and the rapid evolution of Information and Communication Technologies in general have opened a new era in product representation and product information sharing between participants, both inside and outside the enterprise and throughout the product life. In particular, the Product Development Process relies on cross-functional activities involving different domains of expertise that each have their own dedicated tools. This has generated new challenges in terms of collaboration and dissemination of information at large between companies or even within the same organization. Within this context, the work reported herein focuses on a specific stakeholder within product development activities - the prototyping and testing department. Its business is typically related to the planning and building of prototypes in order to perform specific tests on the future product or one of its sub-assemblies. The research project aims at investigating an appropriate framework that leverages configured engineering product information, based on complementary information structures, to share and exchange prototyping and testing information in a Product Lifecycle Management (PLM) perspective. As a first step, a case study based on the retrofit of an aircraft engine is deployed to implement a scenario demonstrating the functionalities to be available within the intended framework. For this purpose, complementary and configurable structures are simulated within the project's PLM system. In a second step are considered the software interoperability issues that don't only affect Design -- Testing interactions, but many other interfaces within either the company -- due to the silo-arrangement -- or the consortiums with partners, in which case the whole PLM platforms could simply be incompatible. A study based on an open source initiative and relying on an improved model of communication is described to show how two natively disparate PLM tools can

  3. Results of a pilot scale melter test to attain higher production rates

    International Nuclear Information System (INIS)

    Elliott, M.L.; Perez, J.M. Jr.; Chapman, C.C.

    1991-01-01

    A pilot-scale melter test was completed as part of the effort to enhance glass production rates. The experiment was designed to evaluate the effects of bulk glass temperature and feed oxide loading. The maximum glass production rate obtained, 86 kg/hr-m 2 , was over 200% better than the previous record for the melter used

  4. Clinical application of T-spot test of Mycobacterium tuberculosis infection for diagnosis of suspected pulmonary tuberculosis patients

    Directory of Open Access Journals (Sweden)

    Xue-ping SHI

    2017-11-01

    Full Text Available Objective To explore the application value of T-spot test of Mycobacterium tuberculosis infection (T-SPOT.TB on diagnosis and differential diagnosis of pulmonary tuberculosis. Methods From Apr. 2014 to Dec. 2016, 700 patients with suspected pulmonary tuberculosis were collected, venous blood (5ml was drawn off and sputum was collected from each patient separately for T-SPOT.TB and pathogens identification (including TB. Chest CT, bronchoscopy brush or biopsy histopathological examination were followed up, cultivation of My. tuberculosis and of common bacteria with sputum or lavage fluid when needed. T-SPOT.TB test was performed according to the kit instruction operation. 2.5×105 peripheral blood mononuclear cells (PBMCs were added into the pre- coated anti- human γ- interferon antibody, and co-incubated separately with two specific My. tuberculosis antigens, namely early secretory targeting 6 (ESAT-6 and culture filtration protein 10 (CFP-10, and then the spot forming cells (SFCs were counted. The gold standard for present study were set as follows: 1 My. tuberculosis smear positive or culture positive; 2 Clinical diagnosis (meet any one is positive. The efficacy of T-SPOT.TB on diagnosing active TB was observed, and then the optimal critical value for diagnosing active TB was determined. Patients diagnosed as active TB were divided into 4 subgroups: initial treatment group, retreatment group, smear or culture positive group, and smear or culture negative group. T-SPOT.TB was carried out to detect A and B antigen, and the difference of formed SFCs was then compared. The present study was approved by the Ethics Committee of Xinjiang Uygur Autonomous Region Chest Hospital. Results Of 700 cases suspected of pulmonary tuberculosis enrolled in present study, 528 out of 624 definite cases (84.6% were finally diagnosed as active tuberculosis (active TB group and 96 cases (15.4% were as without TB infection (non-TB group. Positive results of T

  5. 41 CFR 102-79.105 - What is the Integrated Workplace?

    Science.gov (United States)

    2010-07-01

    ... changing needs of the occupants and the organization. Integrated Workplace concepts support the objectives... Workplace? 102-79.105 Section 102-79.105 Public Contracts and Property Management Federal Property... UTILIZATION OF SPACE Assignment and Utilization of Space Integrated Workplace § 102-79.105 What is the...

  6. 41 CFR 105-64.102 - What is GSA's policy on disclosure of information in a system of records?

    Science.gov (United States)

    2010-07-01

    ... disclosure of information in a system of records? 105-64.102 Section 105-64.102 Public Contracts and Property Management Federal Property Management Regulations System (Continued) GENERAL SERVICES ADMINISTRATION... Responsibilities § 105-64.102 What is GSA's policy on disclosure of information in a system of records? No...

  7. Positron emission tomography imaging of angiogenesis in a murine hindlimb ischemia model with 64Cu-labeled TRC105.

    Science.gov (United States)

    Orbay, Hakan; Zhang, Yin; Hong, Hao; Hacker, Timothy A; Valdovinos, Hector F; Zagzebski, James A; Theuer, Charles P; Barnhart, Todd E; Cai, Weibo

    2013-07-01

    The goal of this study was to assess ischemia-induced angiogenesis with (64)Cu-NOTA-TRC105 positron emission tomography (PET) in a murine hindlimb ischemia model of peripheral artery disease (PAD). CD105 binding affinity/specificity of NOTA-conjugated TRC105 (an anti-CD105 antibody) was evaluated by flow cytometry, which exhibited no difference from unconjugated TRC105. BALB/c mice were anesthetized, and the right femoral artery was ligated to induce hindlimb ischemia, with the left hindlimb serving as an internal control. Laser Doppler imaging showed that perfusion in the ischemic hindlimb plummeted to ∼ 20% of the normal level after surgery and gradually recovered to near normal level on day 24. Ischemia-induced angiogenesis was noninvasively monitored and quantified with (64)Cu-NOTA-TRC105 PET on postoperative days 1, 3, 10, 17, and 24. (64)Cu-NOTA-TRC105 uptake in the ischemic hindlimb increased significantly from the control level of 1.6 ± 0.2 %ID/g to 14.1 ± 1.9 %ID/g at day 3 (n = 3) and gradually decreased with time (3.4 ± 1.9 %ID/g at day 24), which correlated well with biodistribution studies performed on days 3 and 24. Blocking studies confirmed the CD105 specificity of tracer uptake in the ischemic hindlimb. Increased CD105 expression on days 3 and 10 following ischemia was confirmed by histology and reverse transcription polymerase chain reaction (RT-PCR). This is the first report of PET imaging of CD105 expression during ischemia-induced angiogenesis. (64)Cu-NOTA-TRC105 PET may play multiple roles in future PAD-related research and improve PAD patient management by identifying the optimal timing of treatment and monitoring the efficacy of therapy.

  8. 41 CFR 105-1.102 - Relationship of GSPMR to FPMR.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Relationship of GSPMR to FPMR. 105-1.102 Section 105-1.102 Public Contracts and Property Management Federal Property Management Regulations System (Continued) GENERAL SERVICES ADMINISTRATION 1-INTRODUCTION 1.1-Regulations System § 105-1...

  9. Production LHC HTS power lead test results

    CERN Document Server

    Tartaglia, M; Fehér, S; Huang, Y; Orris, D F; Pischalnikov, Y; Rabehl, Roger Jon; Sylvester, C D; Zbasnik, J

    2005-01-01

    The Fermilab Magnet test facility has built and operated a test stand to characterize the performance of HTS power leads. We report here the results of production tests of 20 pairs of 7.5 kA HTS power leads manufactured by industry for installation in feed boxes for the LHC Interaction Region quadrupole strings. Included are discussions of the thermal, electrical, and quench characteristics under "standard" and "extreme" operating conditions, and the stability of performance across thermal cycles.

  10. Production LHC HTS power lead test results

    International Nuclear Information System (INIS)

    Tartaglia, M.A.; Carcagno, R.H.; Feher, S.; Huang, Y.; Orris, D.F.; Pischalnikov, Y.; Rabehl, R.J.; Sylvester, C.; Zbasnik, J.

    2004-01-01

    The Fermilab Magnet test facility has built and operated a test stand to characterize the performance of HTS power leads. We report here the results of production tests of 20 pairs of 7.5 kA HTS power leads manufactured by industry for installation in feed boxes for the LHC Interaction Region quadrupole strings. Included are discussions of the thermal, electrical, and quench characteristics under ''standard'' and ''extreme'' operating conditions, and the stability of performance across thermal cycles

  11. 41 CFR 105-53.134 - Office of Administration.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Office of Administration. 105-53.134 Section 105-53.134 Public Contracts and Property Management Federal Property Management... Associate Administrator for Administration, participates in the executive leadership of the agency...

  12. 42 CFR 431.105 - Consultation to medical facilities.

    Science.gov (United States)

    2010-10-01

    ... State agencies furnish consultative services to hospitals, nursing homes, home health agencies, clinics... 42 Public Health 4 2010-10-01 2010-10-01 false Consultation to medical facilities. 431.105 Section 431.105 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN...

  13. 26 CFR 509.105 - Industrial and commercial profits.

    Science.gov (United States)

    2010-04-01

    ... sales promotion, the orders being transmitted to Switzerland for acceptance, then the profits arising... 26 Internal Revenue 19 2010-04-01 2010-04-01 false Industrial and commercial profits. 509.105 Section 509.105 Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF THE TREASURY (CONTINUED...

  14. Iodox process tests in a transuranium element production campaign

    International Nuclear Information System (INIS)

    Collins, E.D.; Benker, D.E.

    1978-01-01

    The Iodox process removes gaseous iodine from air by oxidation of organic iodides and by hydrolysis-oxidation of free iodine to the stable iodate form. An Iodox system for treatment of the 10 -4 m 3 /s dissolver off-gas (DOG) stream was installed and is used for initial removal of radioiodine, this allowing the Hopcalite-charcoal to serve as a backup system in TRU. During a recent TRU production campaign, three dissolver runs were made to test the Iodox process

  15. 10 CFR 1042.105 - Definitions.

    Science.gov (United States)

    2010-01-01

    ... ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Introduction § 1042.105 Definitions. As used in these Title... a condition to becoming a recipient of Federal financial assistance. Designated agency official... in this section. Federal financial assistance means any of the following, when authorized or extended...

  16. 24 CFR 266.105 - Application requirements.

    Science.gov (United States)

    2010-04-01

    ... HOUSING FINANCE AGENCY RISK-SHARING PROGRAM FOR INSURED AFFORDABLE MULTIFAMILY PROJECT LOANS Housing Finance Agency Requirements § 266.105 Application requirements. (a) Applications for approval as a HUD...

  17. Sampling and Analysis Plan for Release of the 105-C Below-Grade Structures and Underlying Soils

    International Nuclear Information System (INIS)

    Bauer, R.G.

    1998-02-01

    This sampling and analysis plan (SAP) presents the rationale and strategies for the sampling, field measurements, and analyses of the below-grade concrete structures from the Hanford 105-C Reactor Building and the underlying soils consistent with the land-use assumptions in the Record of Decision for the U.S. Department of Energy 100-BC-1, 100-DR-1, and 100-HR-1 Operable Units (ROD) (EPA 1995). This structure is one of nine surplus production reactors in the 100 Area of the Hanford Site. This SAP is based on the data quality objectives developed for the 105-C below-grade structures and underlying soils (BHI 1997)

  18. 40 CFR 5.105 - Definitions.

    Science.gov (United States)

    2010-07-01

    ... EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Introduction § 5.105 Definitions. As... awards Federal financial assistance, or by a recipient, as a condition to becoming a recipient... vocational education, as defined in this section. Federal financial assistance means any of the following...

  19. 22 CFR 229.105 - Definitions.

    Science.gov (United States)

    2010-04-01

    ... OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Introduction § 229.105 Definitions. As used in... awards Federal financial assistance, or by a recipient, as a condition to becoming a recipient... institution of vocational education, as defined in this section. Federal financial assistance means any of the...

  20. 22 CFR 146.105 - Definitions.

    Science.gov (United States)

    2010-04-01

    ... ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Introduction § 146.105 Definitions. As used in these Title... financial assistance, or by a recipient, as a condition to becoming a recipient. Designated agency official... education, or an institution of vocational education, as defined in this section. Federal financial...

  1. Dissolution testing of intermediary products in uranium dioxide production by the sol-gel method

    International Nuclear Information System (INIS)

    Melichar, F.; Landspersky, H.; Urbanek, V.

    1979-01-01

    A method was developed of dissolving polyuranates and uranium dioxides in sulphuric acid and in carbonate solutions for testing intermediate products in the sol-gel process preparation of uranium dioxide. A detailed granulometric analysis of spherical particle dispersion was included as part of the tests. Two different production methods were used for the two types of studied materials. The test results show that the test method is suitable for determining temperature sensitivity of the materials to dissolution reaction. The geometrical distribution of impurities in the spherical particles can be determined from the dissolution kinetics. The method allows the determination of the effect of carbon from impurities on the process of uranium dioxide leaching and is thus applicable for testing materials prepared by the sol-gel method. (Z.M.)

  2. 23 CFR 500.105 - Requirements.

    Science.gov (United States)

    2010-04-01

    ... HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION TRANSPORTATION INFRASTRUCTURE MANAGEMENT MANAGEMENT AND MONITORING SYSTEMS Management Systems § 500.105 Requirements. (a) The metropolitan transportation planning process (23 U.S.C. 134 and 49 U.S.C. 5303-5005) in TMAs shall include a CMS that meets the...

  3. 41 CFR 105-50.303 - Cost basis in lieu of fees.

    Science.gov (United States)

    2010-07-01

    ... § 105-50.303 Cost basis in lieu of fees. Where the cost of services is to be recovered on other than a... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Cost basis in lieu of fees. 105-50.303 Section 105-50.303 Public Contracts and Property Management Federal Property...

  4. 42 CFR 51c.105 - Accord with health planning.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Accord with health planning. 51c.105 Section 51c... COMMUNITY HEALTH SERVICES General Provisions § 51c.105 Accord with health planning. A grant may be made... approval by the appropriate health planning agencies have been met. ...

  5. Baseline sensitivity of maize borers in India to the Bacillus thuringiensis insecticidal proteins Cry1A.105 and Cry2Ab2.

    Science.gov (United States)

    Jalali, Sushil K; Yadavalli, Lalitha; Ojha, Rakshit; Kumar, Pradyumn; Sulaikhabeevi, Suby B; Sharma, Reema; Nair, Rupa; Kadanur, Ravi C; Kamath, Subray P; Komarlingam, Mohan S

    2015-08-01

    Among the major pests of maize in India are two stem borers, Chilo partellus (Swinhoe) and Sesamia inferens (Walker), and an earworm, Helicoverpa armigera (Hübner). As a pest control strategy, transgenic Bacillus thuringiensis (Bt) maize hybrids are undergoing regulatory trials in India. We have determined the sensitivity of the target lepidopterans to the insecticidal Bt proteins expressed in Bt maize, as this determines product efficacy and the resistance management strategy to be adopted. Maize hybrids with event MON89034 express two insecticidal Bt proteins, Cry1A.105 and Cry2Ab2. Sensitivity profiles of 53 populations of C. partellus, 21 populations of S. inferens and 21 populations of H. armigera, collected between 2008 and 2013 from maize-growing areas in India, to Cry1A.105 and Cry2Ab2 proteins were generated through dose-response assays. Cry1A.105 protein was the most effective to neonates of C. partellus (mean MIC90 range 0.30-1.0 µg mL(-1) ) and H. armigera (mean MIC90 range 0.71-8.22 µg mL(-1) ), whereas Cry2Ab2 (mean MIC90 range 0.65-1.70 µg mL(-1) ) was the most effective to S. inferens. Populations of C. partellus, S. inferens and H. armigera were susceptible to the Bt proteins Cry1A.105 and Cry2Ab2. The Bt sensitivity data will serve as precommercialisation benchmarks for resistance monitoring purposes. © 2014 Society of Chemical Industry.

  6. 6 CFR 17.105 - Definitions.

    Science.gov (United States)

    2010-01-01

    ... EDUCATION PROGRAMS OR ACTIVITIES RECEIVING FEDERAL FINANCIAL ASSISTANCE Introduction § 17.105 Definitions... Federal agency that awards Federal financial assistance, or by a recipient, as a condition to becoming a... vocational education, as defined in this section. (g) Federal financial assistance means any of the following...

  7. Shrub biomass production following simulated herbivory: A test of the compensatory growth hypothesis

    Science.gov (United States)

    Terri B. Teaschner; Timothy E. Fulbright

    2007-01-01

    The objective of this experiment was to test the hypotheses that 1) simulated herbivory stimulates increased biomass production in spiny hackberry (Celtis pallida), but decreases biomass production in blackbrush acacia (Acacia rigidula) compared to unbrowsed plants and 2) thorn density and length increase in blackbrush acacia to a...

  8. 46 CFR 111.105-33 - Mobile offshore drilling units.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Mobile offshore drilling units. 111.105-33 Section 111... ELECTRIC SYSTEMS-GENERAL REQUIREMENTS Hazardous Locations § 111.105-33 Mobile offshore drilling units. (a) Applicability. This section applies to each mobile offshore drilling unit. (b) Definitions. As used in this...

  9. 20 CFR 802.105 - Stay of payment pending appeal.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Stay of payment pending appeal. 802.105... PROCEDURE General Provisions Introductory § 802.105 Stay of payment pending appeal. (a) As provided in... ten days after it becomes due pending final decision in any proceeding before the Board unless so...

  10. Out-of-pile demonstration test of hydrogen production system coupling with HTTR

    International Nuclear Information System (INIS)

    Inagaki, Yoshiyuki; Nishihara, Tetsuo; Takeda, Tetsuaki; Hada, Kazuhiko; Hayashi, Koji

    1999-01-01

    In Japan Atomic Energy Research Institute, a hydrogen production system is being designed to produce hydrogen by means of a steam reforming process of natural gas using nuclear heat (10 MW, 905degC) supplied by the High Temperature Engineering Test Reactor (HTTR). The safety principle and criteria are also being investigated in the HTTR hydrogen production system. Prior to coupling of the steam reforming system with the HTTR, an out-of-pile demonstration test was planned to confirm safety, controllability and performance of the steam reforming system under simulated operational conditions of the HTTR hydrogen production system. The out-of-pile test facility simulates key components downstream an intermediate heat exchanger of the HTTR hydrogen production system on a scale of 1 to 30 has a hydrogen production capacity of 110 Nm 3 /h using an electric heater as a reactor substitute. The test facility is under manufacturing aiming at completion in 2000 and followed by the test till 2004. In parallel to this, a hydrogen permeation test and a corrosion test of a catalyst tube of a steam reformer are being carried out to obtain data necessary for the design of the system. This report describes outline of the out-of-pile hydrogen production facility and demonstration test program for the HTTR hydrogen production system at present status. (author)

  11. Out-of-pile demonstration test of hydrogen production system coupling with HTTR

    Energy Technology Data Exchange (ETDEWEB)

    Inagaki, Yoshiyuki; Nishihara, Tetsuo; Takeda, Tetsuaki; Hada, Kazuhiko; Hayashi, Koji [Japan Atomic Energy Research Inst., Oarai, Ibaraki (Japan). Oarai Research Establishment

    1999-07-01

    In Japan Atomic Energy Research Institute, a hydrogen production system is being designed to produce hydrogen by means of a steam reforming process of natural gas using nuclear heat (10 MW, 905degC) supplied by the High Temperature Engineering Test Reactor (HTTR). The safety principle and criteria are also being investigated in the HTTR hydrogen production system. Prior to coupling of the steam reforming system with the HTTR, an out-of-pile demonstration test was planned to confirm safety, controllability and performance of the steam reforming system under simulated operational conditions of the HTTR hydrogen production system. The out-of-pile test facility simulates key components downstream an intermediate heat exchanger of the HTTR hydrogen production system on a scale of 1 to 30 has a hydrogen production capacity of 110 Nm{sup 3}/h using an electric heater as a reactor substitute. The test facility is under manufacturing aiming at completion in 2000 and followed by the test till 2004. In parallel to this, a hydrogen permeation test and a corrosion test of a catalyst tube of a steam reformer are being carried out to obtain data necessary for the design of the system. This report describes outline of the out-of-pile hydrogen production facility and demonstration test program for the HTTR hydrogen production system at present status. (author)

  12. 30 CFR 250.1151 - How often must I conduct well production tests?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false How often must I conduct well production tests... Requirements Well Tests and Surveys § 250.1151 How often must I conduct well production tests? (a) You must conduct well production tests as shown in the following table: You must conduct: And you must submit to...

  13. Produção de enterotoxinas e da toxina da síndrome do choque tóxico por cepas de Staphylococcus aureus isoladas na mastite bovina Production of enterotoxins and toxic shock syndrome toxin by Staphylococcus aureus strains isolated from bovine mastitis

    Directory of Open Access Journals (Sweden)

    A. Nader Filho

    2007-10-01

    Full Text Available A total of 72 strains of Staphylococcus aureus were examined for the production of staphylococcal enterotoxins (SE A, B, C, D and toxic shock syndrome toxin (TSST-1. The strains were isolated from milk samples from cows with mastitis in dairy herds of São Paulo State, Brazil. Off 72 isolates, 38 (52.8% produced SEA, 38 (52.8% SEB, 32 (44.4% SED, 28 (38.9% SEC and 27 (37.5% TSST-1. From the 72 strains, 66 (91.7% produced, at least, one or more toxin, including TSST-1.

  14. Natural gas production verification tests

    International Nuclear Information System (INIS)

    1992-02-01

    This Environmental Assessment (EA) has been prepared by the Department of Energy (DOE) in compliance with the requirements of the National Environmental Policy Act of 1969. The Department of Energy (DOE) proposes to fund, through a contract with Petroleum Consulting Services, Inc. of Canton, Ohio, the testing of the effectiveness of a non-water based hydraulic fracturing treatment to increase gas recovery from low-pressure, tight, fractured Devonian Shale formations. Although Devonian Shales are found in the Appalachian, Michigan, and Illinois Basins, testing will be done only in the dominant, historical five state area of established production. The objective of this proposed project is to assess the benefits of liquid carbon dioxide (CO 2 )/sand stimulations in the Devonian Shale. In addition, this project would evaluate the potential nondamaging (to the formation) properties of this unique fracturing treatment relative to the clogging or chocking of pores and fractures that act as gas flow paths to the wellbore in the target gas-producing zones of the formation. This liquid CO 2 /sand fracturing process is water-free and is expected to facilitate gas well cleanup, reduce the time required for post-stimulation cleanup, and result in improved production levels in a much shorter time than is currently experienced

  15. A Study of Polarization in Hyperon Production Processes

    Energy Technology Data Exchange (ETDEWEB)

    Woods, David McDill [Minnesota U.

    1995-01-01

    The polarization of $\\Xi^-$ and $\\Omega^-$ hyperons produced from both polarized and unpolarized neutral particle beams has been studied. The unpolarized neutral beam production studies are the first measurements made using this production technique. The neutral beam consisted of neutrons, $\\Lambda^0$s, $\\Xi^0$s, $K^0$s, and photons. No polarization was observed in the sample of 1.4 x $10^7 \\Xi^-$s produced by an unpolarized neutral beam. For n-s produced by an unpolarized neutral beam, a sample of 1.7 x $10^5$ events with an average momentum of 394. GeV/c had a polarization of +0.044 $\\pm$ 0.008 and a sample of 5 x 104 events with an average momentum of 304. GeV /c had a polarization of +0.036 $\\pm$ 0.015. The polarization of 7.1 x $10^5 \\Xi^- s$ produced by a polarized neutral beam was -0.118±0.004 at an average momentum of 393. GeV/c. 1.8 x $10^4 \\Omega^- s$ produced by the polarized neutral beam had a polarization of -0.069 $\\pm$ 0.023 at an average momentum of 394. GeV /c. The measurements for production from a polarized neutral beam are in agreement with a previous measurement.

  16. 22 CFR 513.105 - Definitions.

    Science.gov (United States)

    2010-04-01

    ... GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (GRANTS) General § 513.105 Definitions. The following definitions apply to this part: Adequate evidence. Information sufficient to support the reasonable belief... designated by the agency head. Indictment. Indictment for a criminal offense. An information or other filing...

  17. Permanent magnets prepared from Sm10.5Fe88.5Zr1.0Ny without homogenization

    International Nuclear Information System (INIS)

    Gebel, B.; Kubis, M.; Mueller, K.-H.

    1997-01-01

    In as-cast Sm 2 Fe 17 the high amount of α-Fe caused by a peritectic reaction can be considerably reduced by a small addition of about 1 at% Zr. X-ray diffraction showed that as-cast Sm 10.5 Fe 88.5 Zr 1.0 mainly consists of a phase with the Th 2 Zn 17 -type structure and SmFe 3 . Non-homogenized Sm 10.5 Fe 88.5 Zr 1.0 was milled and (i) annealed in vacuum or (ii) treated with a hydrogenation-disproportionation-desorp tion-recombination (HDDR) process. The annealed and subsequently nitrogenated powder is magnetically anisotropic and has a coercivity μ 0J H C up to 2.0 T and an energy product (BH) max up to 136 kJ/m 3 . HDDR-treated and nitrogenated powder is isotropic and exhibits values of μ 0J H C = 3.1 T and (BH) max 103 kJ/m 3 . Consequently, Sm 10.5 Fe 88.5 Zr 1.0 N y (y ∼ 16) permanent magnets with very good properties can be prepared without the time-consuming homogenization procedure. (orig.)

  18. Design and Testing of Subsystems for Mo-99 Production

    Energy Technology Data Exchange (ETDEWEB)

    Gromov, R. [Argonne National Lab. (ANL), Argonne, IL (United States); Bailey, J. [Argonne National Lab. (ANL), Argonne, IL (United States); Virgo, M. [Argonne National Lab. (ANL), Argonne, IL (United States); Chemerisov, S. [Argonne National Lab. (ANL), Argonne, IL (United States); Vandegrift, G. F. [Argonne National Lab. (ANL), Argonne, IL (United States)

    2017-01-01

    Argonne National Laboratory, in cooperation with Los Alamos National Laboratory, is developing technology with NorthStar Medical Technologies to produce 99Mo from the γ,n reaction on a 100Mo target in an electron accelerator. During production runs and thermal testing of the helium-cooled target, it became obvious that a production-scale beam-line configuration would need a collimator to protect the target from accidental beam misplacement or a beam-profile change. A prototype high-power collimator and beam stop were designed and fabricated. Testing indicated that they will be able to operate at full power in the production-scale accelerator.

  19. The behavior of fission products during nuclear rocket reactor tests

    International Nuclear Information System (INIS)

    Bokor, P.C.; Kirk, W.L.; Bohl, R.J.

    1991-01-01

    Fission product release from nuclear rocket propulsion reactor fuel is an important consideration for nuclear rocket development and application. Fission product data from the last six reactors of the Rover program are collected in this paper to provide as basis for addressing development and testing issues. Fission product loss from the fuel will depend on fuel composition and reactor design and operating parameters. During ground testing, fission products can be contained downstream of the reactor. The last Rover reactor tested, the Nuclear Furnance, was mated to an effluent clean-up system that was effective in preventing the discharge of fission products into the atmosphere

  20. Riser configuration, Tank 241-A-105, light duty utility arm

    International Nuclear Information System (INIS)

    Boucher, T.D.

    1994-01-01

    The light-duty utility arm (LDUA) is a seven-joint stainless steel robotic arm with a payload capacity of 75 lb. The robotic arm is deployed vertically with a maximum vertical reach of 63 ft. and a maximum horizontal reach of 13.5 ft. The functional requirements of the LDUA system are mapping and characterization of waste in Hanford single-shell tanks (SST) before and during waste retrieval. The LDUA system consists of a mobile deployment system (MDS), a vertical positioning mast (VPM), a tank riser interface confinement (TRIC), the LDUA, and a controller subsystem or support trailer. Currently, the system is in design and is subject to change; however, the LDUA or robotic arm will be deployed through a 12-in. riser above the tank dome. Field trips were performed to gather specifics for future deployment of the LDUA in Tank 241-A-105. The purpose of this report is to support two previous reports for the investigation of SSTs for deployment of the LDUA system. The first report identified the availability of risers while the second report identified the availability of Tanks 241-A-105, 241-A-S-109, 241-A-T-101, and 241-A-T-109 for deployment of the LDUA system. The second report also identified those 4- and 12-in. risers that could be used for deployment of the LDUA and camera system. This report addresses accessibility to the 241-A Tank Farm and the usability of the Tank 241-A-105 risers. The following information for assisting in the design and deployment of the LDUA will be discussed in this report: radiation survey; flange identification; high resolution video; computer simulated model; and field survey

  1. 42 CFR 475.105 - Prohibition against contracting with health care facilities.

    Science.gov (United States)

    2010-10-01

    ... facilities. 475.105 Section 475.105 Public Health CENTERS FOR MEDICARE & MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) QUALITY IMPROVEMENT ORGANIZATIONS QUALITY IMPROVEMENT ORGANIZATIONS Utilization and Quality Control Quality Improvement Organizations § 475.105 Prohibition against contracting...

  2. A production throughput forecasting system in an automated hard disk drive test operation using GRNN

    Energy Technology Data Exchange (ETDEWEB)

    Samattapapong, N.; Afzulpurkar, N.

    2016-07-01

    The goal of this paper is to develop a pragmatic system of a production throughput forecasting system for an automated test operation in a hard drive manufacturing plant. The accurate forecasting result is necessary for the management team to response to any changes in the production processes and the resources allocations. In this study, we design a production throughput forecasting system in an automated test operation in hard drive manufacturing plant. In the proposed system, consists of three main stages. In the first stage, a mutual information method was adopted for selecting the relevant inputs into the forecasting model. In the second stage, a generalized regression neural network (GRNN) was implemented in the forecasting model development phase. Finally, forecasting accuracy was improved by searching the optimal smoothing parameter which selected from comparisons result among three optimization algorithms: particle swarm optimization (PSO), unrestricted search optimization (USO) and interval halving optimization (IHO). The experimental result shows that (1) the developed production throughput forecasting system using GRNN is able to provide forecasted results close to actual values, and to projected the future trends of production throughput in an automated hard disk drive test operation; (2) An IHO algorithm performed as superiority appropriate optimization method than the other two algorithms. (3) Compared with current forecasting system in manufacturing, the results show that the proposed system’s performance is superior to the current system in prediction accuracy and suitable for real-world application. The production throughput volume is a key performance index of hard disk drive manufacturing systems that need to be forecast. Because of the production throughput forecasting result is useful information for management team to respond to any changing in production processes and resources allocation. However, a practically forecasting system for

  3. A comparison of immunotoxic effects of nanomedicinal products with regulatory immunotoxicity testing requirements.

    Science.gov (United States)

    Giannakou, Christina; Park, Margriet Vdz; de Jong, Wim H; van Loveren, Henk; Vandebriel, Rob J; Geertsma, Robert E

    2016-01-01

    Nanomaterials (NMs) are attractive for biomedical and pharmaceutical applications because of their unique physicochemical and biological properties. A major application area of NMs is drug delivery. Many nanomedicinal products (NMPs) currently on the market or in clinical trials are most often based on liposomal products or polymer conjugates. NMPs can be designed to target specific tissues, eg, tumors. In virtually all cases, NMPs will eventually reach the immune system. It has been shown that most NMs end up in organs of the mononuclear phagocytic system, notably liver and spleen. Adverse immune effects, including allergy, hypersensitivity, and immunosuppression, have been reported after NMP administration. Interactions of NMPs with the immune system may therefore constitute important side effects. Currently, no regulatory documents are specifically dedicated to evaluate the immunotoxicity of NMs or NMPs. Their immunotoxicity assessment is performed based on existing guidelines for conventional substances or medicinal products. Due to the unique properties of NMPs when compared with conventional medicinal products, it is uncertain whether the currently prescribed set of tests provides sufficient information for an adequate evaluation of potential immunotoxicity of NMPs. The aim of this study was therefore, to compare the current regulatory immunotoxicity testing requirements with the accumulating knowledge on immunotoxic effects of NMPs in order to identify potential gaps in the safety assessment. This comparison showed that immunotoxic effects, such as complement activation-related pseudoallergy, myelosuppression, inflammasome activation, and hypersensitivity, are not readily detected by using current testing guidelines. Immunotoxicity of NMPs would be more accurately evaluated by an expanded testing strategy that is equipped to stratify applicable testing for the various types of NMPs.

  4. Impact of Modified 2013 ASCO/CAP Guidelines on HER2 Testing in Breast Cancer. One Year Experience.

    Directory of Open Access Journals (Sweden)

    Zsuzsanna Varga

    Full Text Available The latest guidelines of the American Society of Clinical Oncology/College of American Pathologists (ASCO/CAP to test Human Epidermal Growth Factor Receptor 2 (HER2 in breast cancer after being revised in 2008 underwent a second modification in October 2013. The modification includes changes in cut-offs: 10% strong membranous staining for score 3+ on immunohistochemistry (IHC (previously 30% and using the ratio of >2 or absolute gene-copy-number (6 or more alone or in combination with each other by in-situ-hybridisation technology (previously >2.2 and average copy-number of 6 or more. Hereby we addressed the question, which impact the modified cut-offs had on overall HER2-positivity in a single institution.We prospectively analysed 617 consecutive diagnostic breast-cancer cases which underwent double HER2 testing by immunohistochemistry and fluorescent in-situ hybridisation (FISH, using the modified 2013 ASCO/CAP-guidelines for one year (October 2013-October 2014. Results were compared with HER2-test results on 1,528 consecutive diagnostic breast-cancer cases from two previous years (2011-2012, using the 2008 ASCO/CAP guidelines, also tested with IHC and FISH in each case.Between October 2013 and October 2014, overall HER2-positivity was 15.8% (98 of 617 cases were either IHC 3+ or FISH amplified. 79 of 617 cases (13% were IHC 3+, 96 of 617 cases (15.5% were FISH amplified. Equivocal cases were seen in 25 of 617 cases (4.1%. 22 of 25 equivocal cases (88% in 2013-2014 were IHC 1+ or 2+. In 13 equivocal cases, there was a repeated IHC/FISH testing: 2 of 13 cases (15% became FISH amplified, 1 of 13 cases (7.5% became IHC 3+. In 2011-2012, overall HER2-positivity (IHC/FISH was 13.8% (211 of 1,528 cases. 185 of 1,528 cases (12% were 3+ on IHC, 181 of 1,522 cases (12% were amplified by FISH. Six of 1,528 cases were equivocal by FISH, and interpreted as non-amplified (0.3%.Applying the modified ASCO/CAP guidelines from 2013 resulted in an increase (2

  5. Final Report of Tank 241-C-105 Dissolution, the Phase 2 Study

    International Nuclear Information System (INIS)

    Meznarich, Huei K.; Bolling, Stacey D.; Cooke, Gary A.; Ely, Thomas M.; Herting, Daniel L.; Lachut, James S.; LaMothe, Margaret E.

    2016-01-01

    Three clamshell grab samples were taken from Tank 241-C-105 in October 2015 in accordance with RPP-PLAN-60011. Analytical results of those samples were issued in the report RPP-RPT-59115 by Wastren Advantage, Inc., Hanford Laboratory. Solid phase characterization results were reported separately in LAB-RPT-15-00011 and in RPP-RPT-59147. The major solid phases reported to be present were dawsonite [NaAlCO 3 (OH) 2 ], trona [Na 3 (HCO 3 )(CO 3 )⋅2H 2 O], cejkaite [Na 4 (UO 2 )(CO 3 ) 3 ], and an unidentified organic solid, with minor amounts of gibbsite [Al(OH) 3 ], natrophosphate [Na 7 F(PO 4 ) 2 ⋅19H 2 O], and traces of unidentified iron-rich and manganese-rich phases. Note that the presence of dawsonite, trona, and cejkaite requires a relatively low pH, likely around pH 9 to 10. One aliquot of each grab sample was provided to 222-S Laboratory Process Chemistry for dissolution studies. Phase 1 of the dissolution testing followed the approved test plan, WRPS-1404813, Rev. 3, and examined the behavior of the Tank 241-C-105 solids treated with water, 19M sodium hydroxide, 2M nitric acid, and 0.5M oxalic acid/2M nitric acid. Phase 2 of the testing was conducted in accordance with instructions from the client and emphasized treatment with 19M sodium hydroxide followed by water washing. This is the report of the Phase 2 testing.

  6. The clinical significance of serum SCC-Ag combined with CD105 in patients with cervical cancer during the early stage diagnosis

    Directory of Open Access Journals (Sweden)

    Ru-Chan Ma

    2016-09-01

    Full Text Available Objective: To invest the clinical significance of serum SCC-Ag combined with CD105 in early diagnosis of cervical cancer to provide new ideas for early diagnosis and clinical treatment of cervical cancer. Methods: A total of 74 cases cervical cancer patients were selected as cervical cancer group, and 52 cases uterine fibroids patients were selected as normal cervical group, serum samples were collected in the early morning fasting condition, SCC-Ag and CD105 were checked by ELISA method, SCC-Ag and CD105 of two groups were analyzed by t-test, and to compare SCC-Ag and CD105 in different TMN staging, lymph gland metastasis and non-lymph gland metastasis in patients with cervical cancer, the correlation analysis was used by Pearson correlation analysis method. Results: These results came from ELISA method, comparing with normal cervical group, the SCC-Ag and CD105 of cervical cancer group increased, the difference was statistically significant. Comparing with Ⅰ period of TMN staging, SCC-Ag and CD105 of Ⅱ period increased, Ⅲ, Ⅳ period increased, the difference was statistically significant. Comparing with Ⅱ period, SCC-Ag and CD105 of Ⅲ, Ⅳ period increased, the difference was statistically significant. Comparing with non-lymph gland metastasis, SCC-Ag and CD105 of lymph gland metastasis increased in cervical cancer with surgical treatment, the difference was statistically significant. According to Pearson correlation analysis, SCC-Ag and CD105 were positively correlated. Conclusion: SCC-Ag and CD105 in patients with cervical cancer increase highly, it has important clinical value that of serum SCCAg combined with CD105 in the early diagnosis of cervical cancer, especially it has clinical guiding significance to staging and lymph gland metastasis of cervical cancer, and it is worthy of clinical reference.

  7. 22 CFR 40.105 - Former citizens who renounced citizenship to avoid taxation.

    Science.gov (United States)

    2010-04-01

    ... avoid taxation. 40.105 Section 40.105 Foreign Relations DEPARTMENT OF STATE VISAS REGULATIONS PERTAINING... Miscellaneous § 40.105 Former citizens who renounced citizenship to avoid taxation. An alien who is a former... avoid United States taxation, is ineligible for a visa under INA 212(a)(10)(E). [62 FR 67568, Dec. 29...

  8. 10 CFR 5.105 - Definitions.

    Science.gov (United States)

    2010-01-01

    ... FINANCIAL ASSISTANCE Introduction § 5.105 Definitions. As used in these Title IX regulations, the term... approved by an official of the Federal agency that awards Federal financial assistance, or by a recipient.... Federal financial assistance means any of the following, when authorized or extended under a law...

  9. Effect of demographic data on neuropsychological tests

    Directory of Open Access Journals (Sweden)

    Ahmet Evlice

    2016-09-01

    Material and Methods: Between 2014-2016 years; mini mental state examination, forward and backward digit span, verbal fluency (semantic and lexical, clock drawing, verbal and visual memory tests were performed to healthy people. The presence of correlation between neuropsychological tests and gender, age and education were researched in healthy people. Results: Hundred subjects (60 female, 40 male were included to study. No difference was observed between male and female subjects on neuropsychological tests. There was negative correlation between age and mini mental state examination, digit span and semantic fluency tests. And also there was positive correlation between education and all neuropsychological tests (except verbal memory test. Conclusion: The mean neuropsychological test scores in healthy people were not shown differences by gender, but they were affected by age and education. [Cukurova Med J 2016; 41(3.000: 528-532

  10. 40 CFR 266.105 - Standards to control particulate matter.

    Science.gov (United States)

    2010-07-01

    ... matter. 266.105 Section 266.105 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... prescribed in 40 CFR part 60, appendix A, methods 1 through 5, and appendix IX of this part. (b) An owner or operator meeting the requirements of § 266.109(b) for the low risk waste exemption is exempt from the...

  11. ConocoPhillips Gas Hydrate Production Test

    Energy Technology Data Exchange (ETDEWEB)

    Schoderbek, David [ConocoPhillips Co., Houston, TX (United States); Farrell, Helen [ConocoPhillips Co., Houston, TX (United States); Howard, James [ConocoPhillips Co., Houston, TX (United States); Raterman, Kevin [ConocoPhillips Co., Houston, TX (United States); Silpngarmlert, Suntichai [ConocoPhillips Co., Houston, TX (United States); Martin, Kenneth [ConocoPhillips Co., Houston, TX (United States); Smith, Bruce [ConocoPhillips Co., Houston, TX (United States); Klein, Perry [ConocoPhillips Co., Houston, TX (United States)

    2013-06-30

    Work began on the ConocoPhillips Gas Hydrates Production Test (DOE award number DE-NT0006553) on October 1, 2008. This final report summarizes the entire project from January 1, 2011 to June 30, 2013.

  12. 76 FR 2930 - Market Test of Experimental Product: “Gift Cards”

    Science.gov (United States)

    2011-01-18

    ... POSTAL SERVICE Market Test of Experimental Product: ``Gift Cards'' AGENCY: Postal Service \\TM\\. ACTION: Notice. SUMMARY: The Postal Service gives notice of a market test of an experimental product in... notice pursuant to 39 U.S.C. 3641(c)(1) that it will begin a market test of its ``Gift Cards...

  13. Notice of construction for the 105 KE encapsulation activity

    International Nuclear Information System (INIS)

    1993-03-01

    This is a Notice of Construction for the 105-KE Basin Fuel Encapsulation Activity. This Notice of Construction is being submitted to the State of Washington Department of Health pursuant to the Washington Administrative Code, 246-247, ''Radiation Protection--Air Emissions,'' as amended. The encapsulation activity will consist of all of the activities described in Section 1.3 as necessary to complete encapsulation of the fuel elements and sludge contained in the 105-KE Basin. The encapsulation activity will be carried out on the 105-KE Basin floor under a minimum of 3 m (10 ft) of water. The encapsulation activity.includes emptying irradiated fuel elements from the existing canisters stored in the 105-KE Basin, packaging.these fuel elements in new canisters, packaging sludge from previous fuel inventories and the current inventory in new canisters, capping these canisters of fuel elements and sludge, and returning the new canisters to the storage racks in the basin. The empty canisters will be cleaned and crushed underwater. Packaging and disposal of the crushed canisters will take place above the water

  14. 20 CFR 345.105 - Definitions.

    Science.gov (United States)

    2010-04-01

    ... EMPLOYERS' CONTRIBUTIONS AND CONTRIBUTION REPORTS General Provisions and Definitions § 345.105 Definitions. (a) Chief Financial Officer. References in this part to the Board's Chief Financial Officer mean the... requested from the Board's Chief Financial Officer. (c) Month defined. (1) For the purposes of this part, if...

  15. 7 CFR 1160.105 - Board.

    Science.gov (United States)

    2010-01-01

    ... and Orders; Milk), DEPARTMENT OF AGRICULTURE FLUID MILK PROMOTION PROGRAM Fluid Milk Promotion Order Definitions § 1160.105 Board. Board means the National Processor Advertising and Promotion Board established... Promotion Board or Board). ...

  16. Analyses of production tests and MDT tests conducted in Mallik and Alaska methane hydrate reservoirs : what can we learn from these well tests?

    Energy Technology Data Exchange (ETDEWEB)

    Kurihara, M.; Funatsu, K.; Ouchi, H. [Japan Oil Engineering Co., Tokyo (Japan); Masuda, Y. [Tokyo Univ., Tokyo (Japan). School of Engineering; Yamamoto, K. [Japan Oil, Gas and Metals National Corp., Tokyo (Japan); Narita, H. [National Inst. of Advanced Industrial Science and Technology, Tokyo (Japan); Dallimore, S.R. [Natural Resources Canada, Ottawa, ON (Canada). Geological Survey of Canada; Collett, T.S. [United States Geological Survey, Reston, VA (United States); Hancock, S.H. [APA Petroleum Engineering Ltd., Calgary, AB (Canada)

    2008-07-01

    This paper described a series of pressure drawdown tests conducted to evaluate a modular formation dynamics tester (MDT) wireline tool. The tests were conducted at the Mallik methane hydrate (MH) reservoir as well as in MH reservoirs in Alaska over a period of several years. Production tests were also conducted to evaluate depressurization methods, and measure production and bottomhole pressure (BHP) below known MH stability pressures in order to estimate permeability and MH dissociation radius properties. The results of the tests were then history-matched using a numerical simulator. An analysis of the simulation study showed that the MDT tests were useful in estimating initial effective permeability levels in the presence of MH. However, wellbore storage erased important data used to indicate the radius of MH dissociation and effective permeability after partial MH dissociation. The study also showed that steady flow conditions must be established before obtaining solutions from history-matched production tests. Parameters accurately estimated using the MDT and production tests were outlined, and suggestions for future designs and analyses for MH reservoirs were presented. 14 refs., 7 tabs., 17 figs.

  17. Development of an ASTM standard glass durability test, the Product Consistency Test (PCT), for high level radioactive waste glass

    International Nuclear Information System (INIS)

    Jantzen, C.M.; Bibler, N.E.; Beam, D.C.; Ramsey, W.G.

    1994-01-01

    The nation's first, and the world's largest, facility to immobilize high-level nuclear waste in durable borosilicate glass has started operation at the Savannah River Site (SRS) in Aiken, South Carolina. The product specifications on the glass wasteform produced in the Defense Waste Processing Facility (DWPF) required extensive characterization of the glass product before actual production began and for continued characterization during production. To aid in this characterization, a glass durability (leach) test was needed that was easily reproducible, could be performed remotely on highly radioactive samples, and could yield results rapidly. Several standard leach tests were examined with a variety of test configurations. Using existing tests as a starting point, the DWPF Product Consistency Test (PCT was developed in which crushed glass samples are exposed to 90 ± 2 degree C deionized water for seven days. Based on extensive testing, including a seven-laboratory round robin and confirmatory testing with radioactive samples, the PCT is very reproducible, yields reliable results rapidly, and can be performed in shielded cell facilities with radioactive samples

  18. Test elements of direct sums and free products of free Lie algebras

    Indian Academy of Sciences (India)

    Abstract. We give a characterization of test elements of a direct sum of free Lie algebras in terms of test elements of the factors. In addition, we construct certain types of test elements and we prove that in a free product of free Lie algebras, product of the homogeneous test elements of the factors is also a test element.

  19. Test elements of direct sums and free products of free Lie algebras

    Indian Academy of Sciences (India)

    We give a characterization of test elements of a direct sum of free Lie algebras in terms of test elements of the factors. In addition, we construct certain types of test elements and we prove that in a free product of free Lie algebras, product of the homogeneous test elements of the factors is also a test element.

  20. 76 FR 69481 - Testing and Labeling Pertaining to Product Certification

    Science.gov (United States)

    2011-11-08

    ... 1107 Testing and Labeling Pertaining to Product Certification; Final Rule #0;#0;Federal Register / Vol... Pertaining to Product Certification AGENCY: Consumer Product Safety Commission. ACTION: Final rule. SUMMARY... that the product complies with the certification requirements under section 14(a) of the Consumer...

  1. Superconductivity in a new YBaCuO compound at 105 K

    International Nuclear Information System (INIS)

    Kirschner, I.; Bankuti, J.; Gal, M.; Torkos, K.; Solymos, K.G.; Horvath, G.

    1987-01-01

    A superconducting transition has been detected in a (Y 0.8 Ba 0.2 )(CuO 4-δ ) 2 compound by electrical and magnetic measurements. The resistivity begins to decrease at 173 K and the zero-resistivity state sets in at 105 K

  2. 41 CFR 105-1.101 - General Services Administration Property Management Regulations.

    Science.gov (United States)

    2010-07-01

    ...-INTRODUCTION 1.1-Regulations System § 105-1.101 General Services Administration Property Management Regulations... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false General Services Administration Property Management Regulations. 105-1.101 Section 105-1.101 Public Contracts and Property...

  3. 41 CFR 105-60.405 - Processing requests for confidential commercial information.

    Science.gov (United States)

    2010-07-01

    ... MATERIALS 60.4-Described Records § 105-60.405 Processing requests for confidential commercial information... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Processing requests for confidential commercial information. 105-60.405 Section 105-60.405 Public Contracts and Property Management...

  4. 7 CFR 1463.105 - Base quota levels for eligible quota holders.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 10 2010-01-01 2010-01-01 false Base quota levels for eligible quota holders. 1463.105 Section 1463.105 Agriculture Regulations of the Department of Agriculture (Continued) COMMODITY... TRANSITION PROGRAM Tobacco Transition Payment Program § 1463.105 Base quota levels for eligible quota holders...

  5. 41 CFR 105-68.950 - Excluded Parties List System

    Science.gov (United States)

    2010-07-01

    ... System 105-68.950 Section 105-68.950 Public Contracts and Property Management Federal Property Management Regulations System (Continued) GENERAL SERVICES ADMINISTRATION Regional Offices-General Services... General Services Administration (GSA) containing the names and other information about persons who are...

  6. Project management plan for the 105-C Reactor interim safe storage project. Revision 1

    International Nuclear Information System (INIS)

    Miller, R.L.

    1997-01-01

    In 1942, the Hanford Site was commissioned by the US Government to produce plutonium. Between 1942 and 1955, eight water-cooled, graphite-moderated reactors were constructed along the Columbia River at the Hanford Site to support the production of plutonium. The reactors were deactivated from 1964 to 1971 and declared surplus. The Surplus Production Reactor Decommissioning Project (BHI 1994b) will decommission these reactors and has selected the 105-C Reactor to be used as a demonstration project for interim safe storage at the present location and final disposition of the entire reactor core in the 200 West Area. This project will result in lower costs, accelerated schedules, reduced worker exposure, and provide direct benefit to the US Department of Energy for decommissioning projects complex wide. This project sets forth plans, organizational responsibilities, control systems, and procedures to manage the execution of the Project Management Plan for the 105-C Reactor Interim Safe Storage Project (Project Management Plan) activities to meet programmatic requirements within authorized funding and approved schedules. The Project Management Plan is organized following the guidelines provided by US Department of Energy Order 4700.1, Project Management System and the Richland Environmental Restoration Project Plan (DOE-RL 1992b)

  7. 46 CFR 154.182 - Contiguous hull structure: Production weld test.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Contiguous hull structure: Production weld test. 154.182... Equipment Hull Structure § 154.182 Contiguous hull structure: Production weld test. If a portion of the contiguous hull structure is designed for a temperature colder than −34 °C (−30 °F) and is not part of the...

  8. CD105 promotes chondrogenesis of synovium-derived mesenchymal stem cells through Smad2 signaling.

    Science.gov (United States)

    Fan, Wenshuai; Li, Jinghuan; Wang, Yiming; Pan, Jianfeng; Li, Shuo; Zhu, Liang; Guo, Changan; Yan, Zuoqin

    2016-05-27

    Mesenchymal stem cells (MSCs) are considered to be suitable for cell-based tissue regeneration. Expressions of different cell surface markers confer distinct differentiation potential to different sub-populations of MSCs. Understanding the effect of cell surface markers on MSC differentiation is essential to their targeted application in different tissues. Although CD105 positive MSCs possess strong chondrogenic capacity, the underlying mechanisms are not clear. In this study, we observed a considerable heterogeneity with respect to CD105 expression among MSCs isolated from synovium. The CD105(+) and CD105(-) synovium-derived MSCs (SMSCs) were sorted to compare their differentiation capacities and relative gene expressions. CD105(+) subpopulation had higher gene expressions of AGG, COL II and Sox9, and showed a stronger affinity for Alcian blue and immunofluorescent staining for aggrecan and collagenase II, as compared to those in CD105(-) cells. However, no significant difference was observed with respect to gene expressions of ALP, Runx2, LPL and PPARγ. CD105(+) SMSCs showed increased levels of Smad2 phosphorylation, while total Smad2 levels were similar between the two groups. There was no difference in activation of Smad1/5. These results were further confirmed by CD105-knockdown in SMSCs. Our findings suggest a stronger chondrogenic potential of CD105(+) SMSCs in comparison to that of CD105(-) SMSCs and that CD105 enhances chondrogenesis of SMSCs by regulating TGF-β/Smad2 signaling pathway, but not Smad1/5. Our study provides a better understanding of CD105 with respect to chondrogenic differentiation. Copyright © 2016 Elsevier Inc. All rights reserved.

  9. 105-DR Large Sodium Fire Facility decontamination, sampling, and analysis plan

    International Nuclear Information System (INIS)

    Knaus, Z.C.

    1995-01-01

    This is the decontamination, sampling, and analysis plan for the closure activities at the 105-DR Large Sodium Fire Facility at Hanford Reservation. This document supports the 105-DR Large Sodium Fire Facility Closure Plan, DOE-RL-90-25. The 105-DR LSFF, which operated from about 1972 to 1986, was a research laboratory that occupied the former ventilation supply room on the southwest side of the 105-DR Reactor facility in the 100-D Area of the Hanford Site. The LSFF was established to investigate fire fighting and safety associated with alkali metal fires in the liquid metal fast breeder reactor facilities. The decontamination, sampling, and analysis plan identifies the decontamination procedures, sampling locations, any special handling requirements, quality control samples, required chemical analysis, and data validation needed to meet the requirements of the 105-DR Large Sodium Fire Facility Closure Plan in compliance with the Resource Conservation and Recovery Act

  10. A comparison of immunotoxic effects of nanomedicinal products with regulatory immunotoxicity testing requirements

    Directory of Open Access Journals (Sweden)

    Giannakou C

    2016-06-01

    Full Text Available Christina Giannakou,1,2 Margriet VDZ Park,1 Wim H de Jong,1 Henk van Loveren,1,2 Rob J Vandebriel,1 Robert E Geertsma1 1Centre for Health Protection, National Institute for Public Health and the Environment (RIVM, Bilthoven, 2Department of Toxicogenomics, Maastricht University, Maastricht, the Netherlands Abstract: Nanomaterials (NMs are attractive for biomedical and pharmaceutical applications because of their unique physicochemical and biological properties. A major application area of NMs is drug delivery. Many nanomedicinal products (NMPs currently on the market or in clinical trials are most often based on liposomal products or polymer conjugates. NMPs can be designed to target specific tissues, eg, tumors. In virtually all cases, NMPs will eventually reach the immune system. It has been shown that most NMs end up in organs of the mononuclear phagocytic system, notably liver and spleen. Adverse immune effects, including allergy, hypersensitivity, and immunosuppression, have been reported after NMP administration. Interactions of NMPs with the immune system may therefore constitute important side effects. Currently, no regulatory documents are specifically dedicated to evaluate the immunotoxicity of NMs or NMPs. Their immunotoxicity assessment is performed based on existing guidelines for conventional substances or medicinal products. Due to the unique properties of NMPs when compared with conventional medicinal products, it is uncertain whether the currently prescribed set of tests provides sufficient information for an adequate evaluation of potential immunotoxicity of NMPs. The aim of this study was therefore, to compare the current regulatory immunotoxicity testing requirements with the accumulating knowledge on immunotoxic effects of NMPs in order to identify potential gaps in the safety assessment. This comparison showed that immunotoxic effects, such as complement activation-related pseudoallergy, myelosuppression, inflammasome

  11. 40 CFR 280.105 - Local government financial test.

    Science.gov (United States)

    2010-07-01

    ..., interfund obligations, amounts owed in a trust or agency capacity, and advances and contingent loans from... capacity. For purposes of this test, the calculation of total revenues shall exclude all transfers between... capacity. b. Subtract interfund transfers (dollars)______ c. Total Revenues (dollars)______ 2. Total...

  12. 41 CFR 301-71.105 - Must we issue a written or electronic travel authorization in advance of travel?

    Science.gov (United States)

    2010-07-01

    ... or electronic travel authorization in advance of travel? 301-71.105 Section 301-71.105 Public Contracts and Property Management Federal Travel Regulation System TEMPORARY DUTY (TDY) TRAVEL ALLOWANCES AGENCY RESPONSIBILITIES 71-AGENCY TRAVEL ACCOUNTABILITY REQUIREMENTS Travel Authorization § 301-71.105...

  13. A Conduction-Cooled Superconducting Magnet System-Design, Fabrication and Thermal Tests

    DEFF Research Database (Denmark)

    Song, Xiaowei (Andy); Holbøll, Joachim; Wang, Qiuliang

    2015-01-01

    A conduction-cooled superconducting magnet system with an operating current of 105.5 A was designed, fabricated and tested for material processing applications. The magnet consists of two coaxial NbTi solenoid coils with an identical vertical height of 300 mm and is installed in a high-vacuumed c......A conduction-cooled superconducting magnet system with an operating current of 105.5 A was designed, fabricated and tested for material processing applications. The magnet consists of two coaxial NbTi solenoid coils with an identical vertical height of 300 mm and is installed in a high......-vacuumed cryostat. A two-stage GM cryocooler with a cooling power of 1.5 W at 4.2 K in the second stage is used to cool the system from room temperature to 4.2 K. In this paper, the detailed design, fabrication, thermal analysis and tests of the system are presented....

  14. 46 CFR 164.023-13 - Production tests and inspections.

    Science.gov (United States)

    2010-10-01

    ... Constant Rate of Traverse tensile testing machine, capable of initial clamp separation of ten inches and a... production testing on a lot must meet the following criteria for the lot to be shipped as Coast Guard... the acceptance testing values but not less than the performance minimums. (2) Length/weight values...

  15. 41 CFR 105-53.140 - Office of Operations and Industry Relations.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Office of Operations and Industry Relations. 105-53.140 Section 105-53.140 Public Contracts and Property Management Federal Property... FUNCTIONS Central Offices § 105-53.140 Office of Operations and Industry Relations. The Office of Operations...

  16. ALARA review for the deactivation of 105-N Lift Station

    International Nuclear Information System (INIS)

    Nellesen, A.L.

    1997-01-01

    This ALARA review provides a description of the engineering and administrative controls used to manage personnel exposure and to control contamination levels and airborne radioactivity concentrations, while removing water, sludge, stabilizing surfaces, and all other associated work involved in the deactivation of the 105-N Lift Station. The lift station was used as a sump and received contaminated water from the 105-N Fuel Storage Basin weirs and contaminated drains in the 105-N Building. During operation water from the lift station was pumped to the 1310-N and 1325-N cribs. Deactivation of the lift station is a critical step in completing the deactivation of N-Area

  17. Solid Phase Characterization of Tank 241-C-105 Grab Samples

    International Nuclear Information System (INIS)

    Ely, T. M.; LaMothe, M. E.; Lachut, J. S.

    2016-01-01

    The solid phase characterization (SPC) of three grab samples from single-shell Tank 241-C-105 (C-105) that were received at the laboratory the week of October 26, 2015, has been completed. The three samples were received and broken down in the 11A hot cells.

  18. 41 CFR 105-60.304 - Public information handbook and index.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Public information handbook and index. 105-60.304 Section 105-60.304 Public Contracts and Property Management Federal Property... index. GSA publishes a handbook for the public that identifies information regarding any matter...

  19. Generating and testing methods for consumer-oriented product development

    International Nuclear Information System (INIS)

    2001-10-01

    In order to obtain a good insight into various design methods that can be used by product developers to enable them to develop and test useful domotics products (domotics: intelligent systems for the home), an inventory has been made of the methods used in the Netherlands. The inventory is directed at two categories of methods: (1) Methods of getting better acquainted with the user and/or the problem, and of generating novel solutions: generative methods; and (2) Methods of assessing solutions (through various phases of the designing process): testing methods. The first category of methods concentrates on the designing process. In other words: how can the designer realise as much as possible of the workability of (domotics) products during the designing process? The second category aims at testing a design (in whatever shape: drawing, prototype, functional computer animation, etc.) through its users. These are methods of assessing a design at various stages of the designing process [nl

  20. Transient productivity index for numerical well test simulations

    Energy Technology Data Exchange (ETDEWEB)

    Blanc, G.; Ding, D.Y.; Ene, A. [Institut Francais du Petrole, Pau (France)] [and others

    1997-08-01

    The most difficult aspect of numerical simulation of well tests is the treatment of the Bottom Hole Flowing (BHF) Pressure. In full field simulations, this pressure is derived from the Well-block Pressure (WBP) using a numerical productivity index which accounts for the grid size and permeability, and for the well completion. This productivity index is calculated assuming a pseudo-steady state flow regime in the vicinity of the well and is therefore constant during the well production period. Such a pseudo-steady state assumption is no longer valid for the early time of a well test simulation as long as the pressure perturbation has not reached several grid-blocks around the well. This paper offers two different solutions to this problem: (1) The first one is based on the derivation of a Numerical Transient Productivity Index (NTPI) to be applied to Cartesian grids; (2) The second one is based on the use of a Corrected Transmissibility and Accumulation Term (CTAT) in the flow equation. The representation of the pressure behavior given by both solutions is far more accurate than the conventional one as shown by several validation examples which are presented in the following pages.

  1. 46 CFR 160.077-23 - Production tests and inspections.

    Science.gov (United States)

    2010-10-01

    ... fixed anchor, or (C) a tensile test machine that is capable of holding a given tension. The assembly... testing of each incoming lot of inflation chamber material before using that lot in production; (iii) Have... inspector must perform or supervise testing and inspection of at least one PFD lot in each five lots...

  2. Comparison of experimental data with results of some drying models for regularly shaped products

    Science.gov (United States)

    Kaya, Ahmet; Aydın, Orhan; Dincer, Ibrahim

    2010-05-01

    This paper presents an experimental and theoretical investigation of drying of moist slab, cylinder and spherical products to study dimensionless moisture content distributions and their comparisons. Experimental study includes the measurement of the moisture content distributions of slab and cylindrical carrot, slab and cylindrical pumpkin and spherical blueberry during drying at various temperatures (e.g., 30, 40, 50 and 60°C) at specific constant velocity ( U = 1 m/s) and the relative humidity φ = 30%. In theoretical analysis, two moisture transfer models are used to determine drying process parameters (e.g., drying coefficient and lag factor) and moisture transfer parameters (e.g., moisture diffusivity and moisture transfer coefficient), and to calculate the dimensionless moisture content distributions. The calculated results are then compared with the experimental moisture data. A considerably high agreement is obtained between the calculations and experimental measurements for the cases considered. The effective diffusivity values were evaluated between 0.741 × 10-5 and 5.981 × 10-5 m2/h for slab products, 0.818 × 10-5 and 6.287 × 10-5 m2/h for cylindrical products and 1.213 × 10-7 and 7.589 × 10-7 m2/h spherical products using the Model-I and 0.316 × 10-5-5.072 × 10-5 m2/h for slab products, 0.580 × 10-5-9.587 × 10-5 m2/h for cylindrical products and 1.408 × 10-7-13.913 × 10-7 m2/h spherical products using the Model-II.

  3. Pyocin-sensitivity testing as a method of typing Pseudomonas aeruginosa: use of "phage-free" preparations of pyocin.

    Science.gov (United States)

    Rampling, A; Whitby, J L; Wildy, P

    1975-11-01

    A method for pyocin-sensitivity typing by means of "phage-free" preparations of pyocin is described. The method was tested on 227 isolates of P. aeruginosa, collected from 34 different foci of infection in hospitals in the British Isles and the results were compared with those for combined serological and phage typing of all strains and pyocin production of 105 of the isolates. It is concluded that pyocin-sensitivity typing is a simple and reliable method giving a high degree of discrimination, comparable to that of combined serological and phage typing, and it is suitable for use in routine hospital laboratories.

  4. Final Report of Tank 241-C-105 Dissolution, the Phase 2 Study

    Energy Technology Data Exchange (ETDEWEB)

    Meznarich, Huei K. [Washington River Protection Solutions LLC., Richland, WA (United States); bolling, Stacey D. [Washington River Protection Solutions LLC., Richland, WA (United States); Cooke, Gary A. [Washington River Protection Solutions LLC., Richland, WA (United States); Ely, Thomas M. [Washington River Protection Solutions LLC., Richland, WA (United States); Herting, Daniel L. [Washington River Protection Solutions LLC., Richland, WA (United States); Lachut, James S. [Washington River Protection Solutions LLC., Richland, WA (United States); LaMothe, Margaret E. [Washington River Protection Solutions LLC., Richland, WA (United States)

    2016-10-01

    Three clamshell grab samples were taken from Tank 241-C-105 in October 2015 in accordance with RPP-PLAN-60011. Analytical results of those samples were issued in the report RPP-RPT-59115 by Wastren Advantage, Inc., Hanford Laboratory. Solid phase characterization results were reported separately in LAB-RPT-15-00011 and in RPP-RPT-59147. The major solid phases reported to be present were dawsonite [NaAlCO3(OH)2], trona [Na3(HCO3)(CO3)·2H2O], cejkaite [Na4(UO2)(CO3)3], and an unidentified organic solid, with minor amounts of gibbsite [Al(OH)3], natrophosphate [Na7F(PO4)2·19H2O], and traces of unidentified iron-rich and manganese-rich phases. Note that the presence of dawsonite, trona, and cejkaite requires a relatively low pH, likely around pH 9 to 10. One aliquot of each grab sample was provided to 222-S Laboratory Process Chemistry for dissolution studies. Phase 1 of the dissolution testing followed the approved test plan, WRPS-1404813, Rev. 3, and examined the behavior of the Tank 241-C-105 solids treated with water, 19M sodium hydroxide, 2M nitric acid, and 0.5M oxalic acid/2M nitric acid. Phase 2 of the testing was conducted in accordance with instructions from the client and emphasized treatment with 19M sodium hydroxide followed by water washing. This is the report of the Phase 2 testing.

  5. Urea-formaldehyde resins: production, application, and testing

    Science.gov (United States)

    Nuryawan, A.; Risnasari, I.; Sucipto, T.; Heri Iswanto, A.; Rosmala Dewi, R.

    2017-07-01

    Urea-formaldehyde (UF) resin, one of the most important formaldehyde resin adhesives, is a polymeric condensation product of formaldehyde with urea, and being widely used for the manufacture of wood-based composite panels, such as plywood, particleboard, and fiberboard. In spite of its benefits such as fast curing, good performance in the panels (colorless), and lower cost; formaldehyde emission (FE) originated from either UF resin itself or composite products bonded by UF resins is considered a critical drawback as it affects human health particularly in indoor environment. In order to reduce the FE, lowering formaldehyde/urea (F/U) mole ratio in the synthesis of the UF resin was done. In this study, synthesis of UF resins was carried out following the conventional alkaline-acid two-step reaction with a second addition of urea, resulting in F/U mole ratio around 1.0, namely 0.95; 1.05, and 1.15. The UF resins produced were used as binder for particleboard making. The board was manufactured in the laboratory using shaving type particle of Gmelina wood, 8% UF resin based on oven dry particle, and 1% NH4Cl (20%wt) as hardener for the resin. The target of the thickness was 10 mm and the dimension was 25 cm x 25 cm. The resulted particleboard then was evaluated the physical and the mechanical properties by Japanese Industrial Standard (JIS) A 5908 (2003). Further, the resulted particleboard also was used for the mice cage’s wall in order to mimic the real living environment. After four weeks exposure in the cages, the mice then were evaluated their mucous organs as well as their blood. The experiment results were as follows: 1) It was possible to synthesis UF resins with low F/U mole ratio; 2) However, the particleboard bonded UF resins with low F/U mole ratio showed poor properties, particularly on the thickness swelling and modulus of elasticity; 3) There was no significant differences among the mucous organs of the mice after a month exposure FE originated from

  6. 41 CFR 105-50.401 - Reports submitted to the Congress.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Reports submitted to the Congress. 105-50.401 Section 105-50.401 Public Contracts and Property Management Federal Property... Congress. (a) The Administrator of General Services will furnish annually to the respective Committees on...

  7. 41 CFR 105-8.152 - Program accessibility: Assignment of space.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Program accessibility: Assignment of space. 105-8.152 Section 105-8.152 Public Contracts and Property Management Federal Property...-8.152 Program accessibility: Assignment of space. (a) When GSA assigns or reassigns space to an...

  8. 25 CFR 1000.105 - What are self-governance base budgets?

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 2 2010-04-01 2010-04-01 false What are self-governance base budgets? 1000.105 Section... Base Budgets § 1000.105 What are self-governance base budgets? (a) A Tribe/Consortium self-governance base budget is the amount of recurring funding identified in the President's annual budget request to...

  9. 7 CFR 1221.105 - Vacancies.

    Science.gov (United States)

    2010-01-01

    ... Regulations of the Department of Agriculture (Continued) AGRICULTURAL MARKETING SERVICE (MARKETING AGREEMENTS... INFORMATION ORDER Sorghum Promotion, Research, and Information Order Sorghum Promotion, Research, and Information Board § 1221.105 Vacancies. To fill any vacancy occasioned by the death, removal, resignation, or...

  10. Utilization of steel slag for Portland cement clinker production.

    Science.gov (United States)

    Tsakiridis, P E; Papadimitriou, G D; Tsivilis, S; Koroneos, C

    2008-04-01

    The aim of the present research work is to investigate the possibility of adding steel slag, a by-product of the conversion of iron to steel process, in the raw meal for the production of Portland cement clinker. Two samples of raw meals were prepared, one with ordinary raw materials, as a reference sample ((PC)(Ref)), and another with 10.5% steel slag ((PC)(S/S)). Both raw meals were sintered at 1450 degrees C. The results of chemical and mineralogical analyses as well as the microscopic examination showed that the use of the steel slag did not affect the mineralogical characteristics of the so produced Portland cement clinker. Furthermore, both clinkers were tested by determining the grindability, setting times, compressive strengths and soundness. The hydration products were examined by XRD analysis at 2, 7, 28 and 90 days. The results of the physico-mechanical tests showed that the addition of the steel slag did not negatively affect the quality of the produced cement.

  11. Preliminary Hazard Classification for the 105-B Reactor

    International Nuclear Information System (INIS)

    Kerr, N.R.

    1997-08-01

    This document summarizes the inventories of radioactive and hazardous materials present within the 105-B Reactor and uses the inventory information to determine the preliminary hazard classification for the surveillance and maintenance activities of the facility. The result of this effort was the preliminary hazard classification for the 105-B Building surveillance and maintenance activities. The preliminary hazard classification was determined to be Nuclear Category 3. Additional hazard and accident analysis will be documented in a separate report to define the hazard controls and final hazard classification

  12. 13 CFR 121.105 - How does SBA define “business concern or concern”?

    Science.gov (United States)

    2010-01-01

    ... concern or concernâ? 121.105 Section 121.105 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION... Applicability § 121.105 How does SBA define “business concern or concern”? (a)(1) Except for small agricultural cooperatives, a business concern eligible for assistance from SBA as a small business is a business entity...

  13. 5 CFR 5301.105 - Restrictions applicable to Members of the National Science Board.

    Science.gov (United States)

    2010-01-01

    ... National Science Board. 5301.105 Section 5301.105 Administrative Personnel NATIONAL SCIENCE FOUNDATION SUPPLEMENTAL STANDARDS OF ETHICAL CONDUCT FOR EMPLOYEES OF THE NATIONAL SCIENCE FOUNDATION § 5301.105...) by the Chairman of the National Science Board or by the Designated Agency Ethics Official. (3) A...

  14. 5 CFR 3201.105 - Prohibition on dealings with former employers, associates, and clients.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Prohibition on dealings with former employers, associates, and clients. 3201.105 Section 3201.105 Administrative Personnel FEDERAL DEPOSIT... INSURANCE CORPORATION § 3201.105 Prohibition on dealings with former employers, associates, and clients. (a...

  15. Tank 241-BY-105 rotary core sampling and analysis plan

    International Nuclear Information System (INIS)

    Sasaki, L.M.

    1995-01-01

    This Sampling and Analysis Plan (SAP) identifies characterization objectives pertaining to sample collection, laboratory analytical evaluation, and reporting requirements for two rotary-mode core samples from tank 241-BY-105 (BY-105)

  16. 41 CFR 101-1.105 - Authority for FPMR System.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 2 2010-07-01 2010-07-01 true Authority for FPMR System. 101-1.105 Section 101-1.105 Public Contracts and Property Management Federal Property Management Regulations System FEDERAL PROPERTY MANAGEMENT REGULATIONS GENERAL 1-INTRODUCTION 1.1-Regulation System § 101...

  17. A possible alternative to the error prone modified Hodge test to correctly identify the carbapenemase producing Gram-negative bacteria.

    Science.gov (United States)

    Jeremiah, S S; Balaji, V; Anandan, S; Sahni, R D

    2014-01-01

    The modified Hodge test (MHT) is widely used as a screening test for the detection of carbapenemases in Gram-negative bacteria. This test has several pitfalls in terms of validity and interpretation. Also the test has a very low sensitivity in detecting the New Delhi metallo-β-lactamase (NDM). Considering the degree of dissemination of the NDM and the growing pandemic of carbapenem resistance, a more accurate alternative test is needed at the earliest. The study intends to compare the performance of the MHT with the commercially available Neo-Sensitabs - Carbapenemases/Metallo-β-Lactamase (MBL) Confirmative Identification pack to find out whether the latter could be an efficient alternative to the former. A total of 105 isolates of Klebsiella pneumoniae resistant to imipenem and meropenem, collected prospectively over a period of 2 years were included in the study. The study isolates were tested with the MHT, the Neo-Sensitabs - Carbapenemases/MBL Confirmative Identification pack and polymerase chain reaction (PCR) for detecting the blaNDM-1 gene. Among the 105 isolates, the MHT identified 100 isolates as carbapenemase producers. In the five isolates negative for the MHT, four were found to produce MBLs by the Neo-Sensitabs. The Neo-Sensitabs did not have any false negatives when compared against the PCR. The MHT can give false negative results, which lead to failure in detecting the carbapenemase producers. Also considering the other pitfalls of the MHT, the Neo-Sensitabs--Carbapenemases/MBL Confirmative Identification pack could be a more efficient alternative for detection of carbapenemase production in Gram-negative bacteria.

  18. Changes in stress hormones and metabolism during a 105-day simulated Mars mission.

    Science.gov (United States)

    Strollo, Felice; Vassilieva, Galina; Ruscica, Massimiliano; Masini, Mariangela; Santucci, Daniela; Borgia, Luisa; Magni, Paolo; Celotti, Fabio; Nikiporuc, Igor

    2014-08-01

    The Mars-105 project was aimed at simulating crew's activities, workload, and communication during a mission to Mars, evaluating the homeostatic adaptations to prolonged confinement and cohabitation. Fasting plasma glucose (FPG) and insulin, C-peptide, leptin, cortisol, and NGF and BDNF plasma levels were monitored in six healthy nonsmoking male subjects taking part in a 105-d Mars mission simulation. Samples were collected from each subject before (0 wk), during (2.5 wk; 5 wk; 10 wk; 15 wk), and after confinement (+1 wk). Confinement resulted in impaired glucometabolic parameters, since FPG increased during the first 5 wk (baseline: 85.2 ± 10.8 mg · dl⁻¹; 2.5 wk: 98.4 ± 4.7 mg · dl⁻¹; 5 wk: 92.5 ± 6.0 mg · dl⁻¹) and insulin dropped at 2.5 wk (baseline: 14.4 ± 4.8 mU · L⁻¹; 2.5 wk: 7.7 ± 2.1 mU · L⁻¹), subsequently returning to baseline values. HOMA-IR paralleled plasma insulin, dropping to 1.8 ± 0.5 at 2.5 wk (baseline: 3.0 ± 1.2). At all time-points tested, plasma leptin levels were decreased (baseline: 4.4 ± 3.3 ng · dl⁻¹; 2.5 wk: 1.6 ± 1.2 ng · dl⁻¹; 5 wk: 1.3 ± 0.8 ng · dl⁻¹; 10 wk: 1.5 ± 1.1 ng · dl⁻¹; 15 wk:1.7 ± 0.8 ng · dl⁻¹), whereas cortisol levels were increased (baseline: 10.8 ± 4.9 ng · dl⁻¹; 2.5 wk: 16.8 ± 3.5 ng · dl⁻¹; 5 wk: 18.1 ± 7.6 ng · dl⁻¹; 10 wk: 18.1 ± 8.3 ng · dl⁻¹; 15 wk:14.2 ± 4.4 ng · dl⁻¹), resulting in a negative correlation between these hormones. BDNF levels increased only at 5 and 10 wk (baseline: 67.1 ± 36.0 pg · ml⁻¹; 5 wk: 164 ± 54 pg · ml⁻¹; and 10 wk: 110.2 ± 28.9 pg · ml⁻¹). The data obtained with the Mars-105 experiment suggest that environmental stress has a strong impact upon metabolic and stress response, indicating the need for further studies and the implementation of specific countermeasures.

  19. Gama-gama angular correlations in the 105Rh nucleus

    International Nuclear Information System (INIS)

    Esteves, V.A.P.

    1979-01-01

    The Directional Correlation of γ transitions in 105 Rh have been measured from the β - decay of 105 Ru using a Ge(Li) - Nal(Tl) spectrometers. The measurements were carried out for the (316-469), (500-469), (845-499), (875-469), (878-499), (907-469), (1017-469), (350-326), (393-263), (413-263), (489-149) and (575-149) KeV gama cascades. The present results confirm the spin assignments to several levels in 105 Rh obtained in previous studies. The multipole mixing ratios Δ(E2/M1) for several gama transitions have been calculated from the measured angular correlations. The results are Δ(149)=0.34+-0.01,Δ(262)=-1.27+-0.02 or -0.14+-0.01,Δ(326)=-1.79+-0.01 or 0.014+-0.002, Δ(393)=-7.1+-0.3 or -0.36+-0.01, Δ(489)=0.25+-0.002, Δ(500)=0.7+-0.3 and Δ(907)=-21.7 +8 -31.1 or 0.21+-0.03. The structure of nuclear levels in 105 Rh is discussed briefly in terms of models applicable for nuclide in this mass region [pt

  20. 48 CFR 47.105 - Transportation assistance.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Transportation assistance... MANAGEMENT TRANSPORTATION General 47.105 Transportation assistance. (a) Civilian Government activities that do not have transportation officers, or otherwise need assistance on transportation matters, shall...

  1. Inhibition of In Vitro Leukotriene B-4 Biosynthesis in Human Neutrophil Granulocytes and Docking Studies of Natural Quinones

    Czech Academy of Sciences Publication Activity Database

    Landa, Přemysl; Kutil, Zsófia; Temml, V.; Malík, J.; Kokoška, L.; Widowitz, U.; Přibylová, Marie; Dvořáková, Marcela; Maršík, Petr; Schuster, D.; Bauer, R.; Vaněk, Tomáš

    2013-01-01

    Roč. 8, č. 1 (2013), s. 105-108 ISSN 1934-578X R&D Projects: GA ČR GP525/09/P528; GA MŠk(CZ) MEB061112 Institutional research plan: CEZ:AV0Z50380511 Keywords : 5-Lipoxygenase * Anti-inflammatory activity * Dual COX /LOX inhibition Subject RIV: GM - Food Processing Impact factor: 0.924, year: 2013

  2. 41 CFR 105-64.108 - How does GSA safeguard personal information?

    Science.gov (United States)

    2010-07-01

    ... personal information? 105-64.108 Section 105-64.108 Public Contracts and Property Management Federal Property Management Regulations System (Continued) GENERAL SERVICES ADMINISTRATION Regional Offices-General... GSA safeguard personal information? (a) System managers will establish administrative, technical, and...

  3. Z Production as a Test of Nuclear Effects at the LHC

    CERN Document Server

    Zhang, X; Zhang, Xiaofei; Fai, George

    2002-01-01

    We predict the Z transverse momentum distribution from proton-proton and nuclear collisions at the LHC. After demonstrating that higher-twist nuclear effects are very small, we propose $Z^0$ production as a precision test for leading-twist pQCD in the TeV energy region. We also point out that shadowing may result in unexpected phenomenology at the LHC.

  4. 7 CFR 1721.105 - Application documents.

    Science.gov (United States)

    2010-01-01

    ... and Interest § 1721.105 Application documents. (a) Deferments for financial hardship. A Borrower requesting a section 12 deferment because of financial hardship must submit the following: (1) A summary of the financial position of the Borrower, based on the latest information available (usually less than...

  5. 105-C Reactor interim safe storage project technology integration plan

    International Nuclear Information System (INIS)

    Pulsford, S.K.

    1997-01-01

    The 105-C Reactor Interim Safe Storage Project Technology Integration Plan involves the decontamination, dismantlement, and interim safe storage of a surplus production reactor. A major goal is to identify and demonstrate new and innovative D and D technologies that will reduce costs, shorten schedules, enhance safety, and have the potential for general use across the RL complex. Innovative technologies are to be demonstrated in the following areas: Characterization; Decontamination; Waste Disposition; Dismantlement, Segmentation, and Demolition; Facility Stabilization; and Health and Safety. The evaluation and ranking of innovative technologies has been completed. Demonstrations will be selected from the ranked technologies according to priority. The contractor team members will review and evaluate the demonstration performances and make final recommendations to DOE

  6. Evaluation of nine HIV rapid test kits to develop a national HIV testing algorithm in Nigeria

    Directory of Open Access Journals (Sweden)

    Orji Bassey

    2015-05-01

    Full Text Available Background: Non-cold chain-dependent HIV rapid testing has been adopted in many resource-constrained nations as a strategy for reaching out to populations. HIV rapid test kits (RTKs have the advantage of ease of use, low operational cost and short turnaround times. Before 2005, different RTKs had been used in Nigeria without formal evaluation. Between 2005 and 2007, a study was conducted to formally evaluate a number of RTKs and construct HIV testing algorithms. Objectives: The objectives of this study were to assess and select HIV RTKs and develop national testing algorithms. Method: Nine RTKs were evaluated using 528 well-characterised plasma samples. These comprised 198 HIV-positive specimens (37.5% and 330 HIV-negative specimens (62.5%, collected nationally. Sensitivity and specificity were calculated with 95% confidence intervals for all nine RTKs singly and for serial and parallel combinations of six RTKs; and relative costs were estimated. Results: Six of the nine RTKs met the selection criteria, including minimum sensitivity and specificity (both ≥ 99.0% requirements. There were no significant differences in sensitivities or specificities of RTKs in the serial and parallel algorithms, but the cost of RTKs in parallel algorithms was twice that in serial algorithms. Consequently, three serial algorithms, comprising four test kits (BundiTM, DetermineTM, Stat-Pak® and Uni-GoldTM with 100.0% sensitivity and 99.1% – 100.0% specificity, were recommended and adopted as national interim testing algorithms in 2007. Conclusion: This evaluation provides the first evidence for reliable combinations of RTKs for HIV testing in Nigeria. However, these RTKs need further evaluation in the field (Phase II to re-validate their performance.

  7. Correlation between CD105 expression and postoperative recurrence and metastasis of hepatocellular carcinoma

    Directory of Open Access Journals (Sweden)

    Wang Wei

    2006-05-01

    Full Text Available Abstract Background Angiogenesis is one of the mechanisms most critical to the postoperative recurrence and metastasis of hepatocellular carcinoma (HCC. Thus, finding the molecular markers associated with angiogenesis may help identify patients at increased risk for recurrence and metastasis of HCC. This study was designed to investigate whether CD105 or CD34 could serve as a valid prognostic marker in patients with HCC by determining if there is a correlation between CD105 or CD34 expression and postoperative recurrence or metastasis. Methods Immunohistochemical staining for the CD105, CD34 and vascular endothelial growth factor (VEGF antibodies was performed in 113 HCC tissue specimens containing paracarcinomatous tissue and in 14 normal liver tissue specimens. The quantitation of microvessels identified by anti-CD105 and anti-CD34 monoclonal antibodies and the semiquantitation of VEGF expression identified by anti-VEGF monoclonal antibody were analyzed in conjunction with the clinicopathological characteristics of the HCC and any available follow-up information about the patients from whom the specimens were obtained. Results CD105 was not expressed in the vascular endothelial cells of any normal liver tissue or paracarcinomatous liver tissue but was expressed in the vascular endothelial cells of all HCC tissue. In contrast, CD34 was expressed in the vascular endothelial cells of normal liver tissue, paracarcinomatous tissue, and HCC tissue in the following proportions of specimens: 86.7%, 93.8%, and 100%, respectively. The microvascular densities (MVDs of HCC determined by using an anti-CD105 mAb (CD105-MVD and an anti-CD34 mAb (CD34-MVD, were 71.7 ± 8.3 (SD and 106.3 ± 10.4 (SD, respectively. There was a significant correlation between CD105-MVD and CD34-MVD (r = 0.248, P = 0.021. Although CD34-MVD was significantly correlated with VEGF expression (r = 0.243, P = 0.024, CD105-MVD was more closely correlated (r = 0.300, P= 0.005. The

  8. 48 CFR 46.105 - Contractor responsibilities.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 1 2010-10-01 2010-10-01 false Contractor... CONTRACT MANAGEMENT QUALITY ASSURANCE General 46.105 Contractor responsibilities. (a) The contractor is..., and furnishing such information to the Government as required. (b) The contractor may be required to...

  9. 41 CFR 105-68.455 - What may I do if a lower tier participant fails to disclose the information required under § 105...

    Science.gov (United States)

    2010-07-01

    ... Regulations System (Continued) GENERAL SERVICES ADMINISTRATION Regional Offices-General Services... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What may I do if a lower tier participant fails to disclose the information required under § 105-68.355 to the next higher tier...

  10. Software Testing and its Relationship to the Context of the Product

    Directory of Open Access Journals (Sweden)

    Giordano Soares

    2011-12-01

    Full Text Available Test equipment today have to deal with the growing complexity of the systems under test, while the schedules, budgets and team sizes are not scaled in the same relationship. In addition, the entire test plan cannot be automate and due to time and budget constraints, only a small fraction of all use cases can be covered in the manual tests. For this, the testers must be familiar with the context of the product under test, to design a test plan effective. This article describes the advantages that lead the fact that the testers know the domain of the software product, especially in relation to managing the complexity and problems of selection and prioritization of tests

  11. 41 CFR 105-53.130-4 - Office of Small and Disadvantaged Business Utilization.

    Science.gov (United States)

    2010-07-01

    ... Disadvantaged Business Utilization. 105-53.130-4 Section 105-53.130-4 Public Contracts and Property Management... ORGANIZATION AND FUNCTIONS Central Offices § 105-53.130-4 Office of Small and Disadvantaged Business Utilization. (a) Creation and authority. Public Law 95-507, October 14, 1978, an amendment to the Small...

  12. The outburst duration and duty cycle of GRS1915+105

    Science.gov (United States)

    Deegan, Patrick; Combet, Céline; Wynn, Graham A.

    2009-12-01

    The extraordinarily long outburst of GRS1915+105 makes it one of the most remarkable low-mass X-ray binaries (LMXBs). It has been in a state of constant outburst since its discovery in 1992, an eruption which has persisted ~100 times longer than those of more typical LXMBs. The long orbital period of GRS1915+105 implies that it contains large and massive accretion disc which is able to fuel its extreme outburst. In this paper, we address the longevity of the outburst and quiescence phases of GRS1915+105 using smooth particle hydrodynamics (SPH) simulations of its accretion disc through many outburst cycles. Our model is set in the two-α framework and includes the effects of the thermoviscous instability, tidal torques, irradiation by central X-rays and wind mass loss. We explore the model parameter space and examine the impact of the various ingredients. We predict that the outburst of GRS1915+105 should last a minimum of 20yr and possibly up to ~100yr if X-ray irradiation is very significant. The predicted recurrence times are of the order of 104yr, making the X-ray duty cycle a few 0.1 per cent. Such a low duty cycle may mean that GRS1915+105 is not an anomaly among the more standard LMXBs and that many similar, but quiescent, systems could be present in the Galaxy.

  13. Data quality objectives summary report for 105-N Basin sediment disposition

    International Nuclear Information System (INIS)

    Pisarcik, D.J.

    1996-10-01

    During stabilization of the 105-N Basin, sediments that have accumulated on basin surfaces will be vacuumed, collected in the North Cask Pit of the basin complex, and eventually removed. The environmental assessment for the deactivation of the N Reactor Facilities describes two potential disposition paths for the 105-N Basin sediment: transfer in slurry form to a double-shell tank if determined to be a transuranic waste, or disposal in solid form as a low-level waste. Interim storage of the sediments may be required if a transfer to the Tank Waste Remediation System cannot meet scheduled milestones. Selection of a particular alternative depends on the final characterization of the accumulated sediment, regulatory requirements, cost/benefit analyses, and 105-N Stabilization Project schedule requirements. The 105-N Basin Sediment Process is being conducted in two phases. The scope of the first phase includes identification of the sampling requirements, and the specific analyses required to support evaluation of the sediment disposition options. The objectives of the first phase of the 105-N Basin Sediment DQO Process include the following: identify the relevant acceptance criteria for each of the disposition options; and develop a sampling and analysis plan (SAP) sufficiently through to allow evaluation of sediment analysis results against each set of acceptance criteria

  14. Agreement among the Productivity Components of Eight Presenteeism Tests in a Sample of Health Care Workers.

    Science.gov (United States)

    Thompson, Angus H; Waye, Arianna

    2018-06-01

    Presenteeism (reduced productivity at work) is thought to be responsible for large economic costs. Nevertheless, much of the research supporting this is based on self-report questionnaires that have not been adequately evaluated. To examine the level of agreement among leading tests of presenteeism and to determine the inter-relationship of the two productivity subcategories, amount and quality, within the context of construct validity and method variance. Just under 500 health care workers from an urban health area were asked to complete a questionnaire containing the productivity items from eight presenteeism instruments. The analysis included an examination of test intercorrelations, separately for amount and quality, supplemented by principal-component analyses to determine whether either construct could be described by a single factor. A multitest, multiconstruct analysis was performed on the four tests that assessed both amount and quality to test for the relative contributions of construct and method variance. A total of 137 questionnaires were completed. Agreement among tests was positive, but modest. Pearson r ranges were 0 to 0.64 (mean = 0.32) for Amount and 0.03 to 0.38 (mean = 0.25) for Quality. Further analysis suggested that agreement was influenced more by method variance than by the productivity constructs the tests were designed to measure. The results suggest that presenteeism tests do not accurately assess work performance. Given their importance in the determination of policy-relevant conclusions, attention needs to be given to test improvement in the context of criterion validity assessment. Copyright © 2018 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.

  15. 40 CFR 2.105 - Exemption categories.

    Science.gov (United States)

    2010-07-01

    ... the mandatory disclosure requirements of 5 U.S.C. 552(a): (1)(i) Specifically authorized under... enforcement investigations or prosecutions if such disclosure could reasonably be expected to risk... for Disclosure of Records Under the Freedom of Information Act § 2.105 Exemption categories. (a) The...

  16. 34 CFR 84.105 - Does this part apply to me?

    Science.gov (United States)

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Does this part apply to me? 84.105 Section 84.105 Education Office of the Secretary, Department of Education GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE... Education; or (2) A(n) ED awarding official. (See definitions of award and recipient in §§ 84.605 and 84.660...

  17. Multi-Wavelength Monitoring of GRS 1915+105

    Science.gov (United States)

    Bandyopadhyay, R.; Martini, P.; Gerard, E.; Charles, P. A.; Wagner, R. M.; Shrader, C.; Shahbaz, T.; Mirabel, I. F.

    1997-01-01

    Since its discovery in 1992, the superluminal X-ray transient GRS 1915+105 has been extensively observed in an attempt to understand its behaviour. We present here first results from a multi-wavelength campaign undertaken from July to September 1996. This study includes X-ray data from the RXTE All Sky Monitor and BATSE, two-frequency data from the Nancay radio telescope, and infrared photometry from the 1.8 m Perkins telescope at Lowell Observatory. The first long-term well-sampled IR light curve of GRS 1915+105 is presented herein and is consistent with the interpretation of this source as a long-period binary. We compare the various light curves, searching for correlations in the behaviour of the source at differing wavelengths and for possible periodicities.

  18. An analysis of unit tests of a flight software product line

    NARCIS (Netherlands)

    Ganesan, D.; Lindvall, M.; McComas, D.; Bartholomew, M.; Slegel, S.; Medina, B.; Krikhaar, R.; Verhoef, C.; Dharmalingam, G.; Montgomery, L.P.

    2013-01-01

    This paper presents an analysis of the unit testing approach developed and used by the Core Flight Software System (CFS) product line team at the NASA Goddard Space Flight Center (GSFC). The goal of the analysis is to understand, review, and recommend strategies for improving the CFS' existing unit

  19. TLR4 accessory molecule RP105 (CD180 regulates monocyte-driven arteriogenesis in a murine hind limb ischemia model.

    Directory of Open Access Journals (Sweden)

    Antonius J N M Bastiaansen

    Full Text Available AIMS: We investigated the role of the TLR4-accessory molecule RP105 (CD180 in post-ischemic neovascularization, i.e. arteriogenesis and angiogenesis. TLR4-mediated activation of pro-inflammatory Ly6Chi monocytes is crucial for effective neovascularization. Immunohistochemical analyses revealed that RP105+ monocytes are present in the perivascular space of remodeling collateral arterioles. As RP105 inhibits TLR4 signaling, we hypothesized that RP105 deficiency would lead to an unrestrained TLR4-mediated inflammatory response and hence to enhanced blood flow recovery after ischemia. METHODS AND RESULTS: RP105-/- and wild type (WT mice were subjected to hind limb ischemia and blood flow recovery was followed by Laser Doppler Perfusion Imaging. Surprisingly, we found that blood flow recovery was severely impaired in RP105-/- mice. Immunohistochemistry showed that arteriogenesis was reduced in these mice compared to the WT. However, both in vivo and ex vivo analyses showed that circulatory pro-arteriogenic Ly6Chi monocytes were more readily activated in RP105-/- mice. FACS analyses showed that Ly6Chi monocytes became activated and migrated to the affected muscle tissues in WT mice following induction of hind limb ischemia. Although Ly6Chi monocytes were readily activated in RP105-/- mice, migration into the ischemic tissues was hampered and instead, Ly6Chi monocytes accumulated in their storage compartments, bone marrow and spleen, in RP105-/- mice. CONCLUSIONS: RP105 deficiency results in an unrestrained inflammatory response and monocyte over-activation, most likely due to the lack of TLR4 regulation. Inappropriate, premature systemic activation of pro-inflammatory Ly6Chi monocytes results in reduced infiltration of Ly6Chi monocytes in ischemic tissues and in impaired blood flow recovery.

  20. 7 CFR 1710.105 - State regulatory approvals.

    Science.gov (United States)

    2010-01-01

    ... and Basic Policies § 1710.105 State regulatory approvals. (a) In States where a borrower is required... loans are approved by RUS: (1) Loans requiring an Environmental Impact Statement; (2) Loans to finance...

  1. 5 CFR 7501.105 - Outside employment.

    Science.gov (United States)

    2010-01-01

    ... ETHICAL CONDUCT FOR EMPLOYEES OF THE DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT § 7501.105 Outside... active participation in a business dealing with or related to real estate or manufactured housing including but not limited to real estate brokerage, management and sales, architecture, engineering...

  2. 41 CFR 105-68.365 - What must I do if I learn of information required under § 105-68.355 after entering into a...

    Science.gov (United States)

    2010-07-01

    ... Property Management Regulations System (Continued) GENERAL SERVICES ADMINISTRATION Regional Offices-General... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What must I do if I learn of information required under § 105-68.355 after entering into a covered transaction with a...

  3. Chemical Characterization and Reactivity Testing of Fuel-Oxidizer Reaction Product (Test Report)

    Science.gov (United States)

    1996-01-01

    The product of incomplete reaction of monomethylhydrazine (MMH) and nitrogen tetroxide (NTO) propellants, or fuel-oxidizer reaction product (FORP), has been hypothesized as a contributory cause of an anomaly which occurred in the chamber pressure (PC) transducer tube on the Reaction Control Subsystem (RCS) aft thruster 467 on flight STS-51. A small hole was found in the titanium-alloy PC tube at the first bend below the pressure transducer. It was surmised that the hole may have been caused by heat and pressure resulting from ignition of FORP. The NASA Johnson Space Center (JSC) White Sands Test Facility (WSTF) was requested to define the chemical characteristics of FORP, characterize its reactivity, and simulate the events in a controlled environment which may have lead to the Pc-tube failure. Samples of FORP were obtained from the gas-phase reaction of MMH with NTO under laboratory conditions, the pulsed firings of RCS thrusters with modified PC tubes using varied oxidizer or fuel lead times, and the nominal RCS thruster firings at WSTF and Kaiser-Marquardt. Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), accelerating rate calorimetry (ARC), ion chromatography (IC), inductively coupled plasma (ICP) spectrometry, thermogravimetric analysis (TGA) coupled to FTIR (TGA/FTIR), and mechanical impact testing were used to qualitatively and quantitatively characterize the chemical, thermal, and ignition properties of FORP. These studies showed that the composition of FORP is variable but falls within a limited range of compositions that depends on the fuel loxidizer ratio at the time of formation, composition of the post-formation atmosphere (reducing or oxidizing), and reaction or postreaction temperature. A typical composition contains methylhydrazinium nitrate (MMHN), ammonium nitrate (AN), methylammonium nitrate (MAN), and trace amounts of hydrazinium nitrate and 1,1-dimethylhydrazinium nitrate. The thermal decomposition

  4. Chemical test for mammalian feces in grain products: collaborative study.

    Science.gov (United States)

    Gerber, H R

    1989-01-01

    A collaborative study was conducted to validate the use of the AOAC alkaline phosphatase method for mammalian feces in corn meal, 44.B01-44.B06, for 7 additional products: brown rice cream, oat bran, grits, semolina, pasta flour, farina, and barley plus (a mixture of barley, oat bran, and brown rice). The proposed method determines the presence of alkaline phosphatase, an enzyme contained in mammalian feces, by using phenolphthalein diphosphate as the enzyme substrate in a test agar medium. Fecal matter is separated from the grain products by specific gravity differences in 1% test agar. As the product is distributed on liquid test agar, fecal fragments float while the grain products sink. The alkaline phosphatase cleaves phosphate radicals from phenolphthalein diphosphate, generating free phenolphthalein, which produces a pink to red-purple color around the fecal particles in the previously colorless medium. Collaborators' recovery averages ranged from 21.7 particles (72.3%) for oat bran to 25.3 particles (84.3%) for semolina at the 30 particle spike level. Overall average background was 0.4 positive reactions per food type. The collaborators reported that the method was quick, simple, and easy to use. The method has been approved interim official first action for all 7 grain products.

  5. Production and test of the LHCf microstrip silicon system

    International Nuclear Information System (INIS)

    Bonechi, L.; Adriani, O.; Bongi, M.; Castellini, G.; D'Alessandro, R.; Faus, A.; Haguenauer, M.; Itow, Y.; Kasahara, K.; Macina, D.; Mase, T.; Masuda, K.; Matsubara, Y.; Matsumoto, H.; Menjo, H.; Mizuishi, M.; Muraki, Y.; Papini, P.; Perrot, A.L.; Ricciarini, S.

    2008-01-01

    After a preliminary installation test, successfully performed in 2007, both the detectors of the LHCf experiment are now ready to be installed at the CERN LHC accelerator for the first physics run. A beam test at SPS in September 2007 allowed to verify the performance of the apparata. Production and test of the silicon tracker developed for one of them are shortly discussed in this work.

  6. 49 CFR 40.105 - What happens if the laboratory reports a result different from that expected for a blind specimen?

    Science.gov (United States)

    2010-10-01

    ... different from that expected for a blind specimen? 40.105 Section 40.105 Transportation Office of the... for a blind specimen? (a) If you are an employer, MRO, or C/TPA who submits a blind specimen, and if... expected results (obtained from the supplier of the blind specimen), and direct the laboratory to determine...

  7. 41 CFR 105-70.002 - Definitions.

    Science.gov (United States)

    2010-07-01

    ...-IMPLEMENTATION OF THE PROGRAM FRAUD CIVIL REMEDIES ACT OF 1986 § 105-70.002 Definitions. The following shall have... representation, certification, affirmation, document, record, or accounting or bookkeeping entry made— (1) With...

  8. Pravastatin stimulates angiogenesis in a murine hindlimb ischemia model: a positron emission tomography imaging study with (64)Cu-NOTA-TRC105.

    Science.gov (United States)

    Orbay, Hakan; Hong, Hao; Koch, Jill M; Valdovinos, Hector F; Hacker, Timothy A; Theuer, Charles P; Barnhart, Todd E; Cai, Weibo

    2013-01-01

    In this study, (64)Cu-NOTA-TRC105 (TRC105 is an anti-CD105 monoclonal antibody that binds to both human and murine CD105) positron emission tomography (PET) was used to assess the response to pravastatin treatment in a murine model of peripheral artery disease (PAD). Hindlimb ischemia was induced by ligation of the right femoral arteries in BALB/c mice under anesthesia, and the left hindlimb served as an internal control. Mice in the treatment group were given intraperitoneal pravastatin daily until the end of the study, whereas the animals in the control group were injected with 0.9% sodium chloride solution. Laser Doppler imaging showed that blood flow in the ischemic hindlimb plummeted to ~20% of the normal level after surgery, and gradually recovered to near normal level on day 10 in the treatment group and on day 20 in the control group. Angiogenesis was non-invasively monitored and quantified with (64)Cu-NOTA-TRC105 PET on postoperative days 3, 10, 17, and 24. Tracer uptake at 48 h post-injection in the ischemic hindlimb in the treatment group was significantly higher than that of the control group on day 10 (20.5 ± 1.9 %ID/g vs 11.4 ± 1.5 %ID/g), suggesting increased CD105 expression and higher level of angiogenesis upon pravastatin treatment, and gradually decreased to background levels in both groups (4.9 ± 0.8 %ID/g vs 3.4 ± 1.9 %ID/g on day 24). The in vivo PET data correlated well with ex vivo biodistribution studies performed on day 24. Increased CD105 expression on days 3 and 10 following ischemia was further confirmed by immunofluorescence staining. Taken together, our results indicated that (64)Cu-NOTA-TRC105 PET is a suitable and non-invasive method to monitor the angiogenesis and therapeutic response in PAD, which can also be utilized for non-invasive evaluation of other pro-angiogenic/anti-angiogenic drugs in other cardiovascular diseases and cancer.

  9. The influence of socio-cultural background and product value in usability testing.

    Science.gov (United States)

    Sonderegger, Andreas; Sauer, Juergen

    2013-05-01

    This article examines the influence of socio-cultural background and product value on different outcomes of usability tests. A study was conducted in two different socio-cultural regions, Switzerland and East Germany, which differed in a number of aspects (e.g. economic power, price sensitivity and culture). Product value (high vs. low) was varied by manipulating the price of the product. Sixty-four test participants were asked to carry out five typical user tasks in the context of coffee machine usage, measuring performance, perceived usability, and emotion. The results showed that in Switzerland, high-value products were rated higher in usability than low-value products whereas in East Germany, high-value products were evaluated lower in usability. A similar interaction effect of socio-cultural background and product value was observed for user emotion. Implications are that the outcomes of usability tests do not allow for a simple transfer across cultures and that the mediating influence of perceived product value needs to be taken into consideration. Copyright © 2012 Elsevier Ltd and The Ergonomics Society. All rights reserved.

  10. Development, Production and Testing of 4500 Beam Loss Monitors

    CERN Document Server

    Holzer, E B; Dehning, B; Ferioli, G; Grishin, V; Jimenez, T M; Koshelev, A; Kramer, Daniel; Larionov, A; Taborelli, M; Seleznev, V; Sleptsov, M; Sytin, A; Wevers, I

    2008-01-01

    Beam-loss monitoring (BLM) [1] is a key element in the LHC machine protection. 4250 nitrogen filled ionization chambers (IC) and 350 secondary emission monitors (SEM) have been manufactured and tested at the Institute for High Energy Physics (IHEP) in Protvino, Russia, following their development at CERN. Signal speed and robustness against aging were the main design criteria. Each monitor is permanently sealed inside a stainless-steel cylinder. The quality of the welding was a critical aspect during production. The SEMs are requested to hold a vacuum of $10^{-7}$ bar. Impurity levels from thermal and radiationinduced desorption should remain in the range of parts per million in the ICs. To avoid radiation aging (up to $2·10^{8}$ Gy in 20 years) production of the chambers followed strict UHV requirements. IHEP designed and built the UHV production stand. Due to the required dynamic range of $10^{8}$, the leakage current of the monitors has to stay below 2 pA. Several tests during and after production were ...

  11. Testing two novel stump-lifting heads in a final felling Norway spruce stand

    Energy Technology Data Exchange (ETDEWEB)

    Kaerhae, K. (Metsaeteho Oy, Helsinki (Finland)), Email: kalle.karha@metsateho.fi; Mutikainen, A. (TTS Research, Rajamaeki (Finland)), Email: arto.mutikainen@tts.fi

    2009-07-01

    The use of stump and root wood chips has increased very rapidly in the 21st century in Finland: in the year 2000, the total consumption of stump wood chips for energy generation was 10 GWh, while in 2008 it was around 1.2 TWh. Metsaeteho Oy and TTS Research tested two new stump-lifting devices for lifting stumps in a final felling Norway spruce (picea abies) stand. In the time study with the Vaekevae Stump Processor lifting head, the productivity of stump lifting was 7,5 m3 / E{sub 0}-hour when lifting spruce stumps with a diameter of 30 cm from clayey soil, and 8.3 m3 /E{sub 0}-hour when lifting spruce stumps from sandy soil. When lifting stumps with a diameter of 40 cm, the stump-lifting productivity was 9.0 m3 /E{sub 0}-h (clay) and 10,5 m3 / E{sub 0}-h (sand). The results of this relatively restricted test indicated that the Vaekevae Stump Processor is s reliable and effective stump-lifting head that enables the harvesting of high-quality stump raw material for energy generation. The stump lifting productivity of the other lifting head (Jaervinen) was lower than that of the Vaekevae Strump Processor. Some development suggestions for the Jaervinen lifting head were presented and discussed. (orig.)

  12. 41 CFR 105-68.600 - How do suspension and debarment actions start?

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false How do suspension and debarment actions start? 105-68.600 Section 105-68.600 Public Contracts and Property Management Federal... Relating to Suspension and Debarment Actions § 105-68.600 How do suspension and debarment actions start...

  13. 40 CFR 47.105 - Definitions.

    Science.gov (United States)

    2010-07-01

    ... education agency, as defined in § 47.105(f); (d) Not-for-profit organization means an organization, association, or institution described in section 501(c)(3) of the Internal Revenue Code of 1986, which is... nonprofit affiliates) as defined and licensed by the Federal Communications Commission; (f) Tribal education...

  14. 41 CFR 105-54.101 - Applicability.

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false Applicability. 105-54... consensus advice or recommendations. However, such a group would be covered by the Act when an agency accepts the group's deliberations as a source of consensus advice or recommendations; (i) A meeting of two...

  15. Final report for 105-N Basin sediment disposition task, phase 2 samples BOMPC8 and BOMPC9

    International Nuclear Information System (INIS)

    Esch, R.A.

    1998-01-01

    This document is the final report deliverable for Phase 2 analytical work for the 105-N Basin Sediment Disposition Task. On December 23, 1997, ten samples were received at the 222-S Laboratory as follows: two (2) bottles of potable water, six (6) samples for process control testing and two (2) samples for characterization. Analyses were performed in accordance with the Letter of Instruction for Phase 2 Analytical Work for the 105-N Basin Sediment Disposition Task (Logan and Kessner, 1997) (Attachment 7) and 105-N Basin Sediment Disposition Phase-Two Sampling and Analysis Plan (SAP) (Smith, 1997). The analytical results are included in Table 1. This document provides the values of X/Qs for the onsite and offsite receptors, taking into account the building wake and the atmospheric stability effects. X/Qs values for the potential fire accident were also calculated. In addition, the unit dose were calculated for the mixtures of isotopes

  16. [Sleep structure instability in healthy men under conditions of 105-day isolation experiment "Mars-105"].

    Science.gov (United States)

    Kovrov, G V; Posokhov, S I; Posokhov, S S; Zavalko, I M; Ponomareva, I P

    2013-01-01

    Night-to-night stability of falling asleep and duration of wakefulness in the sleep was studied in six healthy male subjects under conditions of 105-day isolation experiment "Mars-105". Polysomnography records were carried out in each subject during five nights taken in regular intervals within the experiment. Three subjects demonstrated high stability of falling asleep and wakefulness in sleep (group I), whereas in the remaining three subjects stability of these characteristics was low (group [I). Delta-sleep was shown to be deepened in subjects of group II (significant prevalence of stage 4 (47.3 min) over stage 3 (32.9 min)). In subjects of group I, the duration of stage 3 was 44.9 min and that of stage 4 was 26.6 min. We suggest that night-to-night instability of falling asleep and duration of wakefulness in sleep in combination with delta sleep is the special individual form of sleep adaptation to conditions of chronic isolation stress.

  17. Automatic test comes to focal plane array production

    Science.gov (United States)

    Skaggs, Frank L.; Barton, T. D.

    1992-08-01

    To meet the needs of military and commercial markets, the infrared focal plane array industry must develop new, effective and low cost methods of fabricating and testing imaging detectors. This paper describes Texas Instruments new concepts in automated testing and cold probe technology as they apply to volume production.

  18. New product testing and the utilization of user expertise: Evidence from the Pharmaceutical industry

    DEFF Research Database (Denmark)

    Smed, Marie; Salomo, Søren; Schultz, Carsten

    2012-01-01

    A significant and often neglected obstacle in new product development is the testing and approval process in the late stages of development. The testing process has primarily been observed as an in-house decision process, however, in many industries products undergo extensive testing before marke....... Further, with a dispersed user network a positive effect is observed on the mean to communicate directly as issues occur. The effect of virtual communication is therefore stronger than traditional face-to-face interaction patterns.......A significant and often neglected obstacle in new product development is the testing and approval process in the late stages of development. The testing process has primarily been observed as an in-house decision process, however, in many industries products undergo extensive testing before market...... the knowledge generated and shared by medical sites and Pharmaceutical producers in late stage product development. The results show, that information regarding usage patterns and product related services are more difficult to transfer between user and developer, than issues directly related to the product...

  19. Engineering task plan for the development of a high pressure water drill system for BY-105 saltwell screen installation

    International Nuclear Information System (INIS)

    RITTER, G.A.

    1999-01-01

    This engineering task plan identifies the activities required for developing an ultra high pressure water drill system for installation of a saltwell screen in Tank BY-105. A water drill system is needed to bore through the hard waste material in this tank because of the addition of Portland cement in the 1960s and/or 1970s. The activities identified in this plan include the design, procurement, and qualification testing of the water drill along with readiness preparations including developing operating procedures, training Operations personnel, and conducting an assessment of readiness

  20. 23 CFR 635.105 - Supervising agency.

    Science.gov (United States)

    2010-04-01

    ... CONSTRUCTION AND MAINTENANCE Contract Procedures § 635.105 Supervising agency. (a) The STD has responsibility... work with its own forces or by contract; provided the following conditions are met and the Division... compliance with subpart B of this part. (2) When the work is to be performed under a contract awarded by a...

  1. Improvement in reduced-mode (REM) diodes enable 315 W from 105-μm 0.15-NA fiber-coupled modules

    Science.gov (United States)

    Kanskar, M.; Bao, L.; Chen, Z.; Dawson, D.; DeVito, M.; Dong, W.; Grimshaw, M.; Guan, X.; Hemenway, M.; Martinsen, R.; Urbanek, W.; Zhang, S.

    2018-02-01

    High-power, high-brightness diode lasers have been pursued for many applications including fiber laser pumping, materials processing, solid-state laser pumping, and consumer electronics manufacturing. In particular, 915 nm - and 976 nm diodes are of interest as diode pumps for the kilowatt CW fiber lasers. As a result, there have been many technical thrusts for driving the diode lasers to have both high power and high brightness to achieve high-performance and reduced manufacturing costs. This paper presents our continued progress in the development of high brightness fiber-coupled product platform, nLIGHT element®. In the past decade, the power coupled into a single 105 μm and 0.15 NA fiber has increased by over a factor of ten through improved diode laser brightness and the development of techniques for efficiently coupling multiple emitters. In this paper, we demonstrate further brightness improvement and power-scaling enabled by both the rise in chip brightness/power and the increase in number of chips coupled into a given numerical aperture. We report a new chip technology using x-REM design with brightness as high as 4.3 W/mm-mrad at a BPP of 3 mm-mrad. We also report record 315 W output from a 2×12 nLIGHT element with 105 μm diameter fiber using x-REM diodes and these diodes will allow next generation of fiber-coupled product capable of 250W output power from 105 μm/0.15 NA beam at 915 nm.

  2. Comparative product testing of children's restraint systems, with inclusion of side-collision tests

    Energy Technology Data Exchange (ETDEWEB)

    Goerlitz, H. [Stiftung Warentest, Berlin (Germany); Noeske, V. [DEKRA Dresden (Germany)

    2001-07-01

    Stiftung Warentest has conducted comparative product testing for Group 0.. III child car seats to evaluate accident protection, handling, comfort of the seats, and safety against faulty use. The tests that were conducted were intended to provide assessment of product quality. Owing to great reader interest, tests conducted on child car seats have become well established for a considerable number of years now. They enjoy esteemed status, for example, in our magazine test. Stiftung Warentest conducted its first tests on children's restraint system many years ago: in May of 1968. The great interest in this topic, as evidenced by widespread feedback from readers, justifies the high costs occasioned by the dynamic testing of children's restraint systems. The popularity of this topic leads to greater sales of the particular issues of the magazine test - which carries no advertising - and at least compensates for most of the added costs necessary for dynamic collision testing. It is not generally well known that Stiftung Warentest covers approximately 90% of its budget from the sales of its two magazines test and Finanztest, and of its other special publications. The annual subsidy by the German government is relatively small. The national subsidy is intended to compensate for the loss of revenue from the exclusion of advertising. (orig.)

  3. 75 FR 28335 - Testing and Labeling Pertaining to Product Certification

    Science.gov (United States)

    2010-05-20

    ... Product Certification; Proposed Rule #0;#0;Federal Register / Vol. 75, No. 97 / Thursday, May 20, 2010.... CPSC-2010-0038] RIN 3041-AC71 Testing and Labeling Pertaining to Product Certification AGENCY: Consumer... also address labeling of consumer products to show that the product complies with certification...

  4. Radiochemical synthesis of {sup 105g}Ag-labelled silver nanoparticles

    Energy Technology Data Exchange (ETDEWEB)

    Ichedef, C., E-mail: cigdem_ch@yahoo.com; Simonelli, F.; Holzwarth, U. [Institute for Health and Consumer Protection, European Commission, Joint Research Centre (Italy); Bagaria, J. Piella; Puntes, V. F. [Institut Català de Nanotecnologia (ICN2) (Spain); Cotogno, G.; Gilliland, D.; Gibson, N. [Institute for Health and Consumer Protection, European Commission, Joint Research Centre (Italy)

    2013-11-15

    A method for synthesis of radiolabelled silver nanoparticles is reported. The method is based on proton activation of silver metal powder, enriched in {sup 107}Ag, with a 30.7 MeV proton beam. At this proton energy {sup 105g}Ag is efficiently created, mainly via the {sup 107}Ag(p,3n){sup 105}Cd → {sup 105g}Ag reaction. {sup 105g}Ag has a half-life of 41.29 days and emits easily detectable gamma radiation on decay to {sup 105}Pd. This makes it very useful as a tracing radionuclide for experiments over several weeks or months. Following activation and a period to allow short-lived radionuclides to decay, the powder was dissolved in concentrated nitric acid in order to form silver nitrate (AgNO{sub 3}), which was used to synthesise radiolabelled silver nanoparticles via the process of sodium borohydride reduction. For comparison, non-radioactive silver nanoparticles were synthesised using commercially supplied AgNO{sub 3} in order to check if the use of irradiated Ag powder as a starting material would alter in any way the final nanoparticle characteristics. Both nanoparticle types were characterised using dynamic light scattering, zeta-potential and X-ray diffraction measurements, while additionally the non-radioactive samples were analysed by transmission electron microscopy and UV–Vis spectrometry. A hydrodynamic diameter of about 16 nm was determined for both radiolabelled and non-radioactive nanoparticles, while the electron microscopy on the non-radioactive samples indicated that the physical size of the metal NPs was (7.3 ± 1.4) nm.

  5. 41 CFR 105-74.100 - What does this part do?

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 3 2010-07-01 2010-07-01 false What does this part do? 105-74.100 Section 105-74.100 Public Contracts and Property Management Federal Property Management... Administration 74-GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Purpose and Coverage...

  6. 36 CFR 1212.105 - Does this part apply to me?

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 3 2010-07-01 2010-07-01 false Does this part apply to me? 1212.105 Section 1212.105 Parks, Forests, and Public Property NATIONAL ARCHIVES AND RECORDS ADMINISTRATION GENERAL RULES GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Purpose...

  7. Diseases associated with pronounced eosinophilia: a study of 105 dogs in Sweden.

    Science.gov (United States)

    Lilliehöök, I; Gunnarsson, L; Zakrisson, G; Tvedten, H

    2000-06-01

    Records of 105 dogs with pronounced eosinophilia (>2.2 x 10(9) eosinophils/litre) were evaluated in a retrospective study to determine diseases associated with the abnormality in dogs in Sweden. Inflammatory disease in organs with large epithelial surfaces, such as the gut, lungs or skin, was found in 36 per cent of the dogs. A further one-quarter of the 105 cases were placed in the 'miscellaneous' category, which comprised various diseases found at low frequency. The most well defined diagnosis was pulmonary infiltrates with eosinophils in 12 per cent of the dogs. A further 11 per cent had parasitic disease caused by either sarcoptic mange or nasal mite. No atopic dog was found and rottweilers were over-represented in most disease groups. Pronounced eosinophilia, in many cases transient, seems to be associated with a variety of disorders in dogs. In the present study, rottweilers appeared to be more prone to a high eosinophil response than other breeds.

  8. A possible alternative to the error prone modified Hodge test to correctly identify the carbapenemase producing Gram-negative bacteria

    Directory of Open Access Journals (Sweden)

    S S Jeremiah

    2014-01-01

    Full Text Available Context: The modified Hodge test (MHT is widely used as a screening test for the detection of carbapenemases in Gram-negative bacteria. This test has several pitfalls in terms of validity and interpretation. Also the test has a very low sensitivity in detecting the New Delhi metallo-β-lactamase (NDM. Considering the degree of dissemination of the NDM and the growing pandemic of carbapenem resistance, a more accurate alternative test is needed at the earliest. Aims: The study intends to compare the performance of the MHT with the commercially available Neo-Sensitabs - Carbapenemases/Metallo-β-Lactamase (MBL Confirmative Identification pack to find out whether the latter could be an efficient alternative to the former. Settings and Design: A total of 105 isolates of Klebsiella pneumoniae resistant to imipenem and meropenem, collected prospectively over a period of 2 years were included in the study. Subjects and Methods: The study isolates were tested with the MHT, the Neo-Sensitabs - Carbapenemases/MBL Confirmative Identification pack and polymerase chain reaction (PCR for detecting the blaNDM-1 gene. Results: Among the 105 isolates, the MHT identified 100 isolates as carbapenemase producers. In the five isolates negative for the MHT, four were found to produce MBLs by the Neo-Sensitabs. The Neo-Sensitabs did not have any false negatives when compared against the PCR. Conclusions: The MHT can give false negative results, which lead to failure in detecting the carbapenemase producers. Also considering the other pitfalls of the MHT, the Neo-Sensitabs - Carbapenemases/MBL Confirmative Identification pack could be a more efficient alternative for detection of carbapenemase production in Gram-negative bacteria.

  9. 41 CFR 105-54.203-3 - Submission to Library of Congress.

    Science.gov (United States)

    2010-07-01

    ... Congress. 105-54.203-3 Section 105-54.203-3 Public Contracts and Property Management Federal Property... Submission to Library of Congress. The GSA Committee Management Officer furnishes a copy of each charter to the Library of Congress when or shortly after copies are filed with the requisite committees of the...

  10. 5 CFR 950.105 - Principal Combined Fund Organization (PCFO) responsibilities.

    Science.gov (United States)

    2010-01-01

    ... (PCFO) responsibilities. 950.105 Section 950.105 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT... combinations thereof may serve as the PCFO. (b) the primary goal of the PCFO is to conduct an effective and... Government's commitment to non-coercion. Awards to Federal agencies or employees by individual federations or...

  11. Requirement of Hsp105 in CoCl{sub 2}-induced HIF-1α accumulation and transcriptional activation

    Energy Technology Data Exchange (ETDEWEB)

    Mikami, Hiroki; Saito, Youhei, E-mail: ysaito@mb.kyoto-phu.ac.jp; Okamoto, Namiko; Kakihana, Ayana; Kuga, Takahisa; Nakayama, Yuji, E-mail: nakayama@mb.kyoto-phu.ac.jp

    2017-03-15

    The mammalian stress protein Hsp105α protects cells from stress conditions. Several studies have indicated that Hsp105α is overexpressed in many types of solid tumors, which contain hypoxic microenvironments. However, the role of Hsp105α in hypoxic tumors remains largely unknown. We herein demonstrated the involvement of Hsp105α in HIF-1 functions induced by the hypoxia-mimetic agent CoCl{sub 2}. While Hsp105α is mainly localized in the cytoplasm under normal conditions, a treatment with CoCl{sub 2} induces the nuclear localization of Hsp105α, which correlated with HIF-1α expression levels. The overexpression of degradation-resistant HIF-1α enhances the nuclear localization of Hsp105α without the CoCl{sub 2} treatment. The CoCl{sub 2}-dependent transcriptional activation of HIF-1, which is measured using a reporter gene containing a HIF-responsive element, is reduced by the knockdown of Hsp105α. Furthermore, the CoCl{sub 2}-induced accumulation of HIF-1α is enhanced by heat shock, which results in the nuclear localization of Hsp105, and is suppressed by the knockdown of Hsp105. Hsp105 associates with HIF-1α in CoCl{sub 2}-treated cells. These results suggest that Hsp105α plays an important role in the functions of HIF-1 under hypoxic conditions, in which Hsp105α enhances the accumulation and transcriptional activity of HIF-1 through the HIF-1α-mediated nuclear localization of Hsp105α. - Highlights: • Hsp105α is required for the CoCl{sub 2}-induced transcriptional activation and accumulation of HIF-1. • Hsp105α localizes to the nucleus and interacts with HIF-1α in CoCl{sub 2}-treated cells. • Hsp105 enhances the CoCl{sub 2}-induced accumulation of HIF-1α under heat shock conditions.

  12. The 105-Month Swift-BAT All-sky Hard X-Ray Survey

    Science.gov (United States)

    Oh, Kyuseok; Koss, Michael; Markwardt, Craig B.; Schawinski, Kevin; Baumgartner, Wayne H.; Barthelmy, Scott D.; Cenko, S. Bradley; Gehrels, Neil; Mushotzky, Richard; Petulante, Abigail; Ricci, Claudio; Lien, Amy; Trakhtenbrot, Benny

    2018-03-01

    We present a catalog of hard X-ray sources detected in the first 105 months of observations with the Burst Alert Telescope (BAT) coded-mask imager on board the Swift observatory. The 105-month Swift-BAT survey is a uniform hard X-ray all-sky survey with a sensitivity of 8.40× {10}-12 {erg} {{{s}}}-1 {cm}}-2 over 90% of the sky and 7.24× {10}-12 {erg} {{{s}}}-1 {cm}}-2 over 50% of the sky in the 14–195 keV band. The Swift-BAT 105-month catalog provides 1632 (422 new detections) hard X-ray sources in the 14–195 keV band above the 4.8σ significance level. Adding to the previously known hard X-ray sources, 34% (144/422) of the new detections are identified as Seyfert active galactic nuclei (AGNs) in nearby galaxies (zBAT catalog, we release eight-channel spectra and monthly sampled light curves for each object in the online journal and at the Swift-BAT 105-month website.

  13. Tank 241-BY-105 vapor sampling and analysis tank characterization report

    International Nuclear Information System (INIS)

    Huckaby, J.L.

    1995-01-01

    Tank BY-105 headspace gas and vapor samples were collected and analyzed to help determine the potential risks to tank farm workers due to fugitive emissions from the tank. Tank BY-105 is on the Ferrocyanide Watch List. Samples were collected from Tank BY-105 using the vapor sampling system (VSS) on July 7, 1994 by WHC Sampling and Mobile Laboratories. The tank headspace temperature was determined to be 26 C. Air from the Tank BY-105 headspace was withdrawn via a heated sampling probe mounted in riser 10A, and transferred via heated tubing to the VSS sampling manifold. All heated zones of the VSS were maintained at approximately 65 C. Sampling media were prepared and analyzed by WHC, Oak Ridge National Laboratories, Pacific Northwest Laboratories, and Oregon Graduate Institute of Science and Technology through a contract with Sandia National Laboratories. The 46 tank air samples and 2 ambient air control samples collected are listed in Table X-1 by analytical laboratory. Table X-1 also lists the 10 trip blanks provided by the laboratories

  14. State Environmental Policy Act (SEPA) Checklist for the 105-DR Large Sodium Fire Facility Closure Plan

    Energy Technology Data Exchange (ETDEWEB)

    1990-09-01

    The Hanford Site, located northwest of the city of Richland, Washington, houses reactors, chemical-separation systems, and related facilities used for the production of special nuclear materials, as well as for activities associated with nuclear energy development. The 105-DR Large Sodium Fire Facility (LSFF), which was in operation from about 1972 to 1986, was a research laboratory that occupied the former ventilation supply room on the southwest side of the 105-DR Reactor facility. The LSFF was established to provide means of investigating fire and safety aspects associated with large sodium or other metal alkali fires in the liquid metal fast breeder reactor (LMFBR) facilities. The 105-DR Reactor facility was designed and built in the 1950's and is located in the 100-D Area of the Hanford Site. The building housed the DR defense reactor, which was shut down in 1964. The LSFF is subject to the regulatory requirements for the storage and treatment of dangerous wastes. Clean closure is the proposed method of closure for the LSFF. Closure will be conducted pursuant to the requirements of the Washington Administrative Code (WAC) 173-303-610 (Ecology 1989). This closure plan presents a description of the facility, the history of wastes managed, and the procedures that will be followed to close the LSFF as an Alkali Metal Treatment Facility. No future use of the LSFF is expected.

  15. Toward a generic approach for : Stress testing of drug substances and drug products

    NARCIS (Netherlands)

    Klick, Silke; Muijselaar, Pim G.; Waterval, Joop; Eichinger, Thomas; Korn, Christian; Gerding, Thijs K.; Debets, Alexander J.; Sänger-Van De Griend, Cari; Van Den Beld, Cas; Somsen, Govert W.; De Jong, Gerhardus J.

    The Impurity Profiling Group has developed a generic approach for conducting stress testing on drug substances and drug products. The proposed strategy is evaluated and verified with historical data and new experiments. Results demonstrate that the proposed approach is reasonable and generates

  16. 46 CFR 111.105-17 - Wiring methods for hazardous locations.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Wiring methods for hazardous locations. 111.105-17... ENGINEERING ELECTRIC SYSTEMS-GENERAL REQUIREMENTS Hazardous Locations § 111.105-17 Wiring methods for... made with dust-tight cable entrance seals approved for the installation. [CGD 94-108, 61 FR 28284, June...

  17. Partial sums of lagged cross-products of AR residuals and a test for white noise

    NARCIS (Netherlands)

    de Gooijer, J.G.

    2008-01-01

    Partial sums of lagged cross-products of AR residuals are defined. By studying the sample paths of these statistics, changes in residual dependence can be detected that might be missed by statistics using only the total sum of cross-products. Also, a test statistic for white noise is proposed. It is

  18. Quantitative determination of the organ distribution of the cell adhesion molecule cell-CAM 105 by radioimmunoassay

    International Nuclear Information System (INIS)

    Odin, P.; Oebrink, B.

    1987-01-01

    The authors have previously identified a 105,000-Da plasma membrane glycoprotein, denoted cell-CAM 105, that is involved in intercellular adhesion of reaggregating rat hepatocytes. In this communication they report on the development of a radioimmunoassay for cell-CAM 105, employing purified cell-CAM 105, specific antisera against the molecule, and formalin-fixed protein A-containing staphylococci for precipitation of the immune complexes. The assay was shown to be sensitive, specific, precise, rapid, and easy to perform. They used this radioimmunoassay in investigations of the occurrence of cell-CAM 105 in different rat organs. Cell-CAM 105 was present in a wide spectrum of organs in varying amounts. The highest concentrations were found in the gastrointestinal tract, liver, some secretory glands, vagina, kidney, and lung. The results were confirmed by immunoblotting, which revealed one distinct protein component, corresponding to cell-CAM 105, in each positive organ

  19. Testing controlled productive knowledge of adverb-verb collocations ...

    African Journals Online (AJOL)

    A controlled productive test of adverb-verb collocations ..... The third approach to studying collocations, corpus analysis, ..... The collocation web model is thought to match Nation's (2001) psychological .... Theory, analysis, and applications. .... Canadian Modern ... Focus on vocabulary: Mastering the Academic Word List.

  20. Tank 241-U-105 push mode core sampling and analysis plan

    International Nuclear Information System (INIS)

    Bell, K.E.

    1995-01-01

    This Sampling and Analysis Plan (SAP) will identify characterization objectives pertaining to sample collection, laboratory analytical evaluation, and reporting requirements for vapor samples and two push mode core samples from tank 241-U-105 (U-105)

  1. 46 CFR 2.10-105 - Prepayment of annual vessel inspection fees.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 1 2010-10-01 2010-10-01 false Prepayment of annual vessel inspection fees. 2.10-105... VESSEL INSPECTIONS Fees § 2.10-105 Prepayment of annual vessel inspection fees. (a) Vessel owners may prepay the annual vessel inspection fee for any period of not less than three years, and not more than...

  2. Product evaluation of in situ vitrification engineering, Test 4

    International Nuclear Information System (INIS)

    Loehr, C.A.; Weidner, J.R.; Bates, S.O.

    1991-09-01

    This report is one of several that evaluates the In Situ Vitrification (ISV) Engineering-Scale Test 4 (ES-4). This document describes the chemical and physical composition, microstructure, and leaching characteristics of ES-4 product samples; these data provide insight into the expected performance of a vitrified product in an ISV buried waste application similar to that studied in ES-4

  3. Development of post-irradiation test facility for domestic production of 99Mo

    International Nuclear Information System (INIS)

    Taguchi, Taketoshi; Yonekawa, Minoru; Kato, Yoshiaki; Kurosawa, Makoto; Nishikata, Kaori; Ishida, Takuya; Kawamata, Kazuo

    2013-01-01

    JMTR focus on the activation method. By carrying out the preliminary tests using irradiation facilities existing, and verification tests using the irradiation facility that has developed in the cutting-edge research and development strategic strengthening business, as irradiation tests towards the production of 99 Mo, we have been conducting research and development that can contribute to supply about 25% for 99 Mo demand in Japan and the stable supply of radiopharmaceutical. This report describes a summary of the status of the preliminary tests for the production of 99 Mo: Maintenance of test equipment in the facility in JMTR hot laboratory in preparation for research and development for the production of 99 Mo in JMTR and using MoO 3 pellet irradiated at Kyoto University Research Reactor Institute (KUR). (author)

  4. 41 CFR 105-8.103 - Definitions.

    Science.gov (United States)

    2010-07-01

    ... Section 105-8.103 Public Contracts and Property Management Federal Property Management Regulations System... condition, cosmetic disfigurement, or anatomical loss affecting one or more of the following body systems..., epilepsy, muscular dystrophy, multiple sclerosis, cancer, heart disease, diabetes, mental retardation...

  5. 40 CFR 1048.301 - When must I test my production-line engines?

    Science.gov (United States)

    2010-07-01

    ... engines? 1048.301 Section 1048.301 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM NEW, LARGE NONROAD SPARK-IGNITION ENGINES Testing Production-line Engines § 1048.301 When must I test my production-line engines? (a) If you produce engines...

  6. 40 CFR 1045.301 - When must I test my production-line engines?

    Science.gov (United States)

    2010-07-01

    ... engines? 1045.301 Section 1045.301 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION CONTROLS CONTROL OF EMISSIONS FROM SPARK-IGNITION PROPULSION MARINE ENGINES AND VESSELS Testing Production-line Engines § 1045.301 When must I test my production-line engines? (a) If you produce...

  7. 42 CFR 64a.105 - What are the conditions of obligated service?

    Science.gov (United States)

    2010-10-01

    ... under the Mental Health Systems Act or the Community Mental Health Centers Act; (iii) A psychiatric... FELLOWSHIPS, INTERNSHIPS, TRAINING OBLIGATED SERVICE FOR MENTAL HEALTH TRAINEESHIPS § 64a.105 What are the... alcohol, drug abuse or mental health services to one or more of the priority population groups listed in...

  8. Development and Justification of a Risk Evaluation Matrix To Guide Chemical Testing Necessary To Select and Qualify Plastic Components Used in Production Systems for Pharmaceutical Products.

    Science.gov (United States)

    Jenke, Dennis

    2015-01-01

    An accelerating trend in the pharmaceutical industry is the use of plastic components in systems used to produce an active pharmaceutical ingredient or a finished drug product. If the active pharmaceutical ingredient, the finished drug product, or any solution used to generate them (for example, a process stream such as media, buffers, eluents, and the like) is contacted by a plastic component at any time during the production process, substances leached from the component may accumulate in the active pharmaceutical ingredient or finished drug product, affecting its safety and/or efficacy. In this article the author develops and justifies a semi-quantitative risk evaluation matrix that is used to determine the amount and rigor of component testing necessary and appropriate to establish that the component is chemically suitable for its intended use. By considering key properties of the component, the contact medium, the contact conditions, and the active pharmaceutical ingredient's or finished drug product's clinical conditions of use, use of the risk evaluation matrix produces a risk score whose magnitude reflects the accumulated risk that the component will interact with the contact solution to such an extent that component-related extractables will accumulate in the active pharmaceutical ingredient or finished drug product as leachables at levels sufficiently high to adversely affect user safety. The magnitude of the risk score establishes the amount and rigor of the testing that is required to select and qualify the component, and such testing is broadly grouped into three categories: baseline assessment, general testing, and full testing (extractables profiling). Production suites used to generate pharmaceuticals can include plastic components. It is possible that substances in the components could leach into manufacturing solutions and accumulate in the pharmaceutical product. In this article the author develops and justifies a semi-quantitative risk

  9. PET Imaging of Abdominal Aortic Aneurysm with 64Cu-Labeled Anti-CD105 Antibody Fab Fragment.

    Science.gov (United States)

    Shi, Sixiang; Orbay, Hakan; Yang, Yunan; Graves, Stephen A; Nayak, Tapas R; Hong, Hao; Hernandez, Reinier; Luo, Haiming; Goel, Shreya; Theuer, Charles P; Nickles, Robert J; Cai, Weibo

    2015-06-01

    The critical challenge in abdominal aortic aneurysm (AAA) research is the accurate diagnosis and assessment of AAA progression. Angiogenesis is a pathologic hallmark of AAA, and CD105 is highly expressed on newly formed vessels. Our goal was to use (64)Cu-labeled anti-CD105 antibody Fab fragment for noninvasive assessment of angiogenesis in the aortic wall in a murine model of AAA. Fab fragment of TRC105, a mAb that specifically binds to CD105, was generated by enzymatic papain digestion and conjugated to NOTA (1,4,7-triazacyclononane-1,4,7-triacetic acid) for (64)Cu labeling. The binding affinity/specificity of NOTA-TRC105-Fab was evaluated by flow cytometry and various ex vivo studies. BALB/c mice were anesthetized and treated with calcium phosphate to induce AAA and underwent weekly PET scans using (64)Cu-NOTA-TRC105-Fab. Biodistribution and autoradiography studies were also performed to confirm the accuracy of PET results. NOTA-TRC105-Fab exhibited high purity and specifically bound to CD105 in vitro. Uptake of (64)Cu-NOTA-TRC105-Fab increased from a control level of 3.4 ± 0.1 to 9.5 ± 0.4 percentage injected dose per gram (%ID/g) at 6 h after injection on day 5 and decreased to 7.2 ± 1.4 %ID/g on day 12, which correlated well with biodistribution and autoradiography studies (i.e., much higher tracer uptake in AAA than normal aorta). Of note, enhanced AAA contrast was achieved, due to the minimal background in the abdominal area of mice. Degradation of elastic fibers and highly expressed CD105 were observed in ex vivo studies. (64)Cu-NOTA-TRC105-Fab cleared rapidly through the kidneys, which enabled noninvasive PET imaging of the aorta with enhanced contrast and showed increased angiogenesis (CD105 expression) during AAA. (64)Cu-NOTA-TRC105-Fab PET may potentially be used for future diagnosis and prognosis of AAA. © 2015 by the Society of Nuclear Medicine and Molecular Imaging, Inc.

  10. An in vivo mechanism for the reduced peripheral neurotoxicity of NK105: a paclitaxel-incorporating polymeric micellar nanoparticle formulation

    Directory of Open Access Journals (Sweden)

    Nakamura I

    2017-02-01

    Full Text Available Iwao Nakamura, Eiji Ichimura, Rika Goda, Hitomi Hayashi, Hiroko Mashiba, Daichi Nagai, Hirofumi Yokoyama, Takeshi Onda, Akira Masuda Nanomedicine Group, Pharmaceutical Research Laboratories, Nippon Kayaku Co., Ltd., Tokyo, Japan Abstract: In our previous rodent studies, the paclitaxel (PTX-incorporating polymeric micellar nanoparticle formulation NK105 had showed significantly stronger antitumor effects and reduced peripheral neurotoxicity than PTX dissolved in Cremophor® EL and ethanol (PTX/CRE. Thus, to elucidate the mechanisms underlying reduced peripheral neurotoxicity due to NK105, we performed pharmacokinetic analyses of NK105 and PTX/CRE in rats. Among neural tissues, the highest PTX concentrations were found in the dorsal root ganglion (DRG. Moreover, exposure of DRG to PTX (Cmax_PTX and AUC0-inf._PTX in the NK105 group was almost half that in the PTX/CRE group, whereas exposure of sciatic and sural nerves was greater in the NK105 group than in the PTX/CRE group. In histopathological analyses, damage to DRG and both peripheral nerves was less in the NK105 group than in the PTX/CRE group. The consistency of these pharmacokinetic and histopathological data suggests that high levels of PTX in the DRG play an important role in the induction of peripheral neurotoxicity, and reduced distribution of PTX to the DRG of NK105-treated rats limits the ensuing peripheral neurotoxicity. In further analyses of PTX distribution to the DRG, Evans blue (Eb was injected with BODIPY®-labeled NK105 into rats, and Eb fluorescence was observed only in the DRG. Following injection, most Eb dye bound to albumin particles of ~8 nm and had penetrated the DRG. In contrast, BODIPY®–NK105 particles of ~90 nm were not found in the DRG, suggesting differential penetration based on particle size. Because PTX also circulates as PTX–albumin particles of ~8 nm following injection of PTX/CRE, reduced peripheral neurotoxicity of NK105 may reflect exclusion from the

  11. 105-KE Basin Pilot Run design plan

    International Nuclear Information System (INIS)

    Sherrell, D.L.

    1994-01-01

    This document identifies all design deliverables and procedures applicable to the 105-KE Basin Pilot Run. It also establishes a general design strategy, defines interface control requirements, and covers planning for mechanical, electrical, instrument/control system, and equipment installation design

  12. Description of fuel element brush assembly's fabrication for 105-K west

    International Nuclear Information System (INIS)

    Maassen, D.P.

    1997-01-01

    This report is a description of the process to redesign and fabricate, as well as, describe the features of the Fuel Element Brush Assembly used in the 105-K West Basin. This narrative description will identify problems that occurred during the redesigning and fabrication of the 105-K West Basin Fuel Element Brush Assembly and specifically address their solutions

  13. Test marketing of new smokeless tobacco products in four U.S. cities.

    Science.gov (United States)

    Rogers, John D; Biener, Lois; Clark, Pamela I

    2010-01-01

    This exploratory study was designed to assess the availability, price, and point-of-purchase marketing strategies for new smokeless tobacco products in 4 test market areas. A random sample of 50 gas stations, convenience and food stores, and tobacco shops was selected in each of 4 test market areas. Pairs of observers visited each store, recorded product information, and engaged vendors in conversation about product demand. Snus was available in 64% of the stores, but availability and price differed by brand. Point-of-purchase marketing also varied by brand on a variety of dimensions and all brands appeared to be marketed primarily to smokers. Camel Snus was described by store attendants as having the highest demand and was also the most expensive of the observed products. In light of the number of test market cities and intensity of promotion at retail locations, Camel Snus was the most intensively marketed product. The results appear to reflect differences in marketing strategy by American snus manufacturers. These strategies may help to predict future marketing of snus and other tobacco products and may provide a baseline for later assessments of product acceptance.

  14. Isolation and screening of heterocystous cyanobacterial strains for biodiesel production by evaluating the fuel properties from fatty acid methyl ester (FAME) profiles.

    Science.gov (United States)

    Anahas, Antonyraj Matharasi Perianaika; Muralitharan, Gangatharan

    2015-05-01

    This study reports on the biodiesel quality parameters of eleven heterocystous cyanobacterial strains based on fatty acid methyl esters (FAME) profiles. The biomass productivity of the tested cyanobacterial strains ranged from 9.33 to 20.67 mg L(-1) d(-1) while the lipid productivity varied between 0.65 and 2.358 mg L(-1) d(-1). The highest biomass and lipid productivity was observed for Calothrix sp. MBDU 013 but its lipid content is only 11.221 in terms of percent dry weight, next to the Anabaena sphaerica MBDU 105, whose lipid content is high. To identify the most competent isolate, a multi-criteria decision analyses (MCDA) was performed by including the key chemical and physical parameters of biodiesel calculated from FAME profiles. The isolate A.sphaerica MBDU 105 is the most promising biodiesel feed stock based on decision vector through Preference Ranking Organisation Method for Enrichment Evaluation (PROMETHEE) and Graphical Analysis for Interactive Assistance (GAIA) analysis. Copyright © 2014 Elsevier Ltd. All rights reserved.

  15. MicroCHP: Overview of selected technologies, products and field test results

    Energy Technology Data Exchange (ETDEWEB)

    Kuhn, Vollrad [Berliner Energieagentur GmbH, Franzoesische Strasse 23, 10117 Berlin (Germany); Klemes, Jiri; Bulatov, Igor [Centre for Process Integration, CEAS, The University of Manchester, P.O. Box 88, M60 1QD Manchester (United Kingdom)

    2008-11-15

    This paper gives an overview on selected microCHP technologies and products with the focus on Stirling and steam machines. Field tests in Germany, the UK and some other EC countries are presented, assessed and evaluated. Test results show the overall positive performance with differences in sectors (domestic vs. small business). Some negative experiences have been received, especially from tests with the Stirling engines and the free-piston steam machine. There are still obstacles for market implementation. Further projects and tests of microCHP are starting in various countries. When positive results will prevail and deficiencies are eliminated, a way to large-scale production and market implementation could be opened. (author)

  16. Orally inhaled drug performance testing for product development, registration, and quality control.

    Science.gov (United States)

    Lastow, Orest; Svensson, Mårten

    2014-12-01

    A DPI can be split into three different modules; device, formulation, process. These are developed in parallel, and together with the user they provide the performance of an inhalation product. During product development, these modules are evolving and changing, whereas the requirements on an inhalation product are always expressed in terms of the performance of the final commercial product. To do performance testing during development when the product is not finished presents many challenges and can be confusing and misleading. During development, the performance of the final product is typically being predicted by testing ever changing prototypes. This article describes methods and approaches to manage such development and to, during development, provide relevant predictions of the in vitro and in vivo performances of the final product.

  17. Use of test results from the percolation leaching test (TS3) in the framework of the Construction Products Directive

    Energy Technology Data Exchange (ETDEWEB)

    Van Zomeren, A.; Dijkstra, J.J. [ECN Environment and Energy Engineering, Petten (Netherlands); Mesman, M.; Spijker, J. [National Institute for Public Health and the Environment RIVM, Bilthoven (Netherlands); Eikelboom, R. [Ministry of Infrastructure and Environment IenM, Den Haag (Netherlands)

    2013-10-15

    The enforcement of the European Construction Products Directive (and the more actual Construction Products Regulation) has led to the development of European harmonised standards for assessment of the emission of 'dangerous substances' from construction materials. According to Basic Working Requirement (BWR) number 3, the emissions from construction products to soil and groundwater should not have an unacceptable impact on the environmental quality over the life cycle of the product. In this paper the technical needs and boundary conditions of leaching tests to obtain meaningful and reliable test results are explained. Although this paper will not go into detail on 'impact assessment' and the resulting development of regulatory criteria, we will show that the technical needs and boundary conditions of a test are to some extent dependent on what type of information is needed by regulators for environmental impact assessment. This short paper focuses on explaining the principles of testing leaching behaviour of aggregates, and briefly explains the leaching of size reduced and non-size reduced particles. It provides information for the actual discussions on size reduction before leaching tests.

  18. 33 CFR 127.105 - Layout and spacing of marine transfer area for LNG.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Layout and spacing of marine transfer area for LNG. 127.105 Section 127.105 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF... AND LIQUEFIED HAZARDOUS GAS Waterfront Facilities Handling Liquefied Natural Gas § 127.105 Layout and...

  19. Protocol for production of a chewable material for masticatory function tests (Optocal - Brazilian version

    Directory of Open Access Journals (Sweden)

    Rafael de Liz Pocztaruk

    2008-12-01

    Full Text Available The present article aimed to present a standardized protocol for the production of a chewable test material that has been used in masticatory efficiency and performance studies. This chewable material has advantages in respect to its physical properties when compared to other artificial and natural test foods. It is constituted by mixing condensation silicon (58.3% by weight, common plaster (10.2% by weight, alginate (12.5% by weight, solid vaseline (11.5% by weight, tooth paste (7.5% by weight, and catalyst paste (20.8 mg/g, adding also three drops of mint essence. The mixed material is then inserted into an acrylic mould with perforations of 12 mm in diameter and 5 mm in height to produce rounded tablets with those measures after polymerization. It was named "Optocal - Brazilian version". A volume of 3 cm³ is indicated for a chewing test, which corresponds to 12 tablets using the present methodology. The present protocol can make the production of this chewable material easier, helping in its standardization for studies on masticatory function.

  20. Psychometric characteristics of single-word tests of children's speech sound production.

    Science.gov (United States)

    Flipsen, Peter; Ogiela, Diane A

    2015-04-01

    Our understanding of test construction has improved since the now-classic review by McCauley and Swisher (1984). The current review article examines the psychometric characteristics of current single-word tests of speech sound production in an attempt to determine whether our tests have improved since then. It also provides a resource that clinicians may use to help them make test selection decisions for their particular client populations. Ten tests published since 1990 were reviewed to determine whether they met the 10 criteria set out by McCauley and Swisher (1984), as well as 7 additional criteria. All of the tests reviewed met at least 3 of McCauley and Swisher's (1984) original criteria, and 9 of 10 tests met at least 5 of them. Most of the tests met some of the additional criteria as well. The state of the art for single-word tests of speech sound production in children appears to have improved in the last 30 years. There remains, however, room for improvement.