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Sample records for proctitis ulcerosa activa

  1. Proctitis

    Science.gov (United States)

    ... surgery in which the passage of stool is diverted from the rectum. Food protein-induced proctitis. This ... Nondiscrimination Advertising Mayo Clinic is a not-for-profit organization and proceeds from Web advertising help support ...

  2. Ulcerative Proctitis

    OpenAIRE

    Whitlow, Charles B.

    2004-01-01

    Ulcerative proctitis is an idiopathic mucosal inflammatory disease involving only the rectum and is therefore an anatomically limited form of ulcerative colitis. Diagnosis is made based on clinical presentation, endoscopic appearance, and histopathology. Additionally, other etiologies of proctitis are excluded. The course of the disease is variable ranging from complete resolution to easily maintained remission to frequent relapses or refractory disease. Extension of inflammatory changes invo...

  3. Irradiation proctitis

    International Nuclear Information System (INIS)

    Minami, Akira

    1977-01-01

    Literatures on late rectal injuries are discussed, referring to two patients with uterine cervical cancer in whom irradiation proctitis occurred after telecobalt irradiation following uterine extirpation. To one patients, a total of 5000 rads was irradiated, dividing into 250 rads at one time, and after 3 months, irradiation with a total of 2000 rads, dividing into 200 rads at one time, was further given. In another one patient, two parallel opposing portal irradiation with a total of 6000 rads was given. About a year after the irradiation, rectal injuries and cystitis, accompanying with hemorrhage, were found in both of the patients. Rectal amputation and proctotoreusis were performed. Cystitis was treated by cystic irradiation in the urological department. Pathohistological studies of the rectal specimen revealed atrophic mucosa, and dilatation of the blood vessels and edema in the colonic submucosa. Incidence of this disease, term when the disease occurs, irradiation dose, type of the disease, treatment and prevention are described on the basis of the literatures. (Kanao, N.)

  4. Irradiation proctitis

    Energy Technology Data Exchange (ETDEWEB)

    Minami, A [Osaka Kita Tsishin Hospital (Japan)

    1977-06-01

    Literatures on late rectal injuries are discussed, referring to two patients with uterine cervical cancer in whom irradiation proctitis occurred after telecobalt irradiation following uterine extirpation. To one patients, a total of 5000 rads was irradiated, dividing into 250 rads at one time, and after 3 months, irradiation with a total of 2000 rads, dividing into 200 rads at one time, was further given. In another one patient, two parallel opposing portal irradiation with a total of 6000 rads was given. About a year after the irradiation, rectal injuries and cystitis, accompanying with hemorrhage, were found in both of the patients. Rectal amputation and proctotoreusis were performed. Cystitis was treated by cystic irradiation in the urological department. Pathohistological studies of the rectal specimen revealed atrophic mucosa, and dilatation of the blood vessels and edema in the colonic submucosa. Incidence of this disease, term when the disease occurs, irradiation dose, type of the disease, treatment and prevention are described on the basis of the literatures.

  5. Colitis ulcerosa idiopática

    Directory of Open Access Journals (Sweden)

    Manuel Sánchez Herrera

    1944-07-01

    IV El prof. Manson-Bahr ratifica plenamente el concepto de los autores de que el enfermo Fideligno Suárez murió de una Colitis Ulcerosa Idiopática con claros signos de neumonía lobar posiblemente neumocóccica.

  6. Lymphogranuloma venereum proctitis

    Science.gov (United States)

    Harrison, Tucker; Stroup, Jeff

    2016-01-01

    We describe a 60-year-old man who presented with rectal pain and bleeding of a month's duration. His presentation was highly suggestive of lymphogranuloma venereum (LGV) proctitis. Nucleic acid amplification for chlamydia and gonorrhea via rectal swab revealed evidence supportive of anorectal chlamydia. Treatment with doxycycline resulted in complete resolution of his symptoms. PMID:27695183

  7. Surgical treatment of radiation proctitis

    Energy Technology Data Exchange (ETDEWEB)

    Maruyama, Izumi; Sato, Gohei; Okaue, Toyotake; Isobe, Yoshinari; Ohtsu, Akira; Sugimoto, Yuzo (Kansai Electric Power Co., Inc., Osaka (Japan))

    1982-08-01

    Severe radiation proctitis was surgically treated in 8 cases. Colostomy was performed in 2 cases, total resection of the rectum in 2 and proctectomy with colostomy in 4. Perineal abscess developed in the 2 cases with total resection of the rectum. Rather than completely resection of the lesion, a procedure leaving no dead space i.e. proctectomy with colostomy, is desirable for radiation proctitis. Complete preoperative examination of the condition of the underlying disease and possible urinary tract complications is important.

  8. Immunohistological studies in radiation proctitis

    International Nuclear Information System (INIS)

    Honke, Yoshifumi; Katsuta, Shizutomo; Haruma, Ken

    1985-01-01

    Immunohistological studies of radiation proctitis were performed in comparison with those in control subjects, with special reference to the number of immunoglobulin bearing cells in the rectal mucosa. The results obtained were as follows: 1) The rates of distribution of immunoglobulin bearing cells were 16.9% in IgG, 71.7% in IgA, and 11.4% in IgM in control subjects. 2) The number of IgG bearing cells in acute and late radiation proctitis markedly decreased in comparison with those in control subjects. 3) The number of IgA bearing cells in the patients with acute radiation proctitis decreased slightly and recovere 1 in late phase. 4) The number of IgM bearing cells markedly decreased in 11 Gy to 30 Gy radiation group with acute phase. 5) No significant difference could be found in the number of immunoglobulin bearing cells in late radiation proctitis with and without rectal bleeding. 6) Serum immunoglobulin levels of patients with acute radiation proctitis decreased and were well correlated with change the number of immunoglobulin bearing cells. (author)

  9. Surgical treatment of radiation proctitis

    International Nuclear Information System (INIS)

    Maruyama, Izumi; Sato, Gohei; Okaue, Toyotake; Isobe, Yoshinari; Ohtsu, Akira; Sugimoto, Yuzo

    1982-01-01

    Severe radiation proctitis was surgically treated in 8 cases. Colostomy was performed in 2 cases, total resection of the rectum in 2 and proctectomy with colostomy in 4. Perineal abscess developed in the 2 cases with total resection of the rectum. Rather than completely resection of the lesion, a procedure leaving no dead space i.e. proctectomy with colostomy, is desirable for radiation proctitis. Complete preoperative examination of the condition of the underlying disease and possible urinary tract complications is important. (Chiba, N.)

  10. La escucha activa

    OpenAIRE

    Galera Campos, María Victoria; Molina Moreno, María Mercedes

    2016-01-01

    Todos anhelamos ser profundamente comprendidos y aceptados por nuestros semejantes. La escucha activa es un ingrediente básico de las relaciones humanas sanas. Los patrones de no escucha vienen desde nuestra infancia. Si se trata a los infantes como a cualquier ser humano, con la salvedad de ser pequeños, aprenderán a escuchar. En una revisión bibliográfica cualitativa, a través de textos, la mayoría de ellos relacionados con la psicolingüística, nos aparecen los antecedentes sobre dicha temá...

  11. [Gonorrheal proctitis imitating proctalgia fugax].

    Science.gov (United States)

    Nechvátal, A; Masek, T; Hoch, J; Hercogová, J

    2004-01-01

    Proctalgia fugax is usually a source of many diagnostic and therapeutic problems. It is often very difficult to find the cause of the pain. Case-report of a 27-year-old patient who was examined by surgeons on cramp-like pain localized to the rectum. The careful history and laboratory examination confirmed gonorrheal proctitis. She was then successfully treated with ceftriaxon.

  12. Helicobacter pylori y enfermedad péptica ulcerosa

    Directory of Open Access Journals (Sweden)

    Noel Padrón Pérez

    1998-12-01

    Full Text Available Se realizó una revisión dirigida a los médicos de la familia sobre la relación del Helicobacter pylori y la enfermedad péptica ulcerosa. Se incluyen datos epidemiológicos y métodos diagnósticos de la infección. El papel de Helicobacter pylori en la génesis de las recidivas ulcerosas y la significativa disminución de las recurrencias posterior a la erradicación con la terapia antimicrobiana, son aspectos abordados en el presente trabajo. La inmunización como arma de prevención y tratamiento sería un importante logro que se menciona como una futura alternativa para combatir la úlcera asociada a la infecciónA review on the connection of Helicobacter pylori with peptic ulcer disease was made for the family physicians. Epidemiological data and diagnostic methods were included. The role of Helicobacter pylori in the genesis of ulcer relapses and the significant reduction of recurrences after the erradication with antimicrobial therapy are approached in the present paper. Immunization as an instrument of prevention and treatment would be an important achievement that is mentioned as a future alternative to fight ulcer associated with the infection

  13. Proctitis

    Science.gov (United States)

    ... Definition & Facts Symptoms & Causes Diagnosis Treatment Eating, Diet, & Nutrition Clinical Trials Acid Reflux (GER & GERD) in Children & Teens Definition & Facts Symptoms & Causes Diagnosis Treatment Eating, Diet, & Nutrition Clinical Trials Acid Reflux (GER & GERD) in Infants Definition & ...

  14. An initial report of polaprezinc suppositories to radiation proctitis

    International Nuclear Information System (INIS)

    Doi, Hiroshi; Kamikonya, Norihiko; Takada, Yasuhiro

    2010-01-01

    Although radiation proctitis is one of popular adverse effects, standard treatments are not established. We reported 5 cases with the administration of polaprezinc suppositories to radiation proctitis. We made polaprezinc suppositories and administered to 5 patients with radiation proctitis. It was possible to administer it safely. 3 cases have the improvement of the symptoms. And one case had endoscopic findings improved significantly. Polaprezinc may be one of the treatments to radiation proctitis. (author)

  15. Hyperbaric oxygen treatment for radiation proctitis

    International Nuclear Information System (INIS)

    Woo, Tony Choon Seng; Joseph, David; Oxer, Harry

    1997-01-01

    Purpose: Our objective was to assess, retrospectively, the efficacy of hyperbaric oxygen treatment in radiation proctitis in all patients who have completed treatment for this disease at the Fremantle Hyperbaric Oxygen Unit. This unit is the only one of its kind in Western Australia. Methods and Materials: Patients were assessed by a review of hospital records, blood bank records, and clinic review (if this was convenient), and all patients responded to a telephone survey. Patients were questioned regarding radiation proctitis symptoms and the degree to which each had improved. Results: Most patients had previously been treated with radiotherapy for prostate carcinoma. Patients with proctitis mainly suffered from bleeding, diarrhoea, incontinence, and pain. In more than half of these patients, symptoms partially or completely resolved after hyperbaric oxygen treatment. Conclusion: Radiation-induced proctitis is a difficult clinical problem to treat and will probably become more significant with the rising incidence of diagnosis of prostate cancer. Hyperbaric Oxygen should be considered in the treatment of radiation-induced proctitis. Further prospective trials with strict protocol guidelines are warranted

  16. Delayed Microbial Cure of Lymphogranuloma Venereum Proctitis with Doxycycline Treatment

    NARCIS (Netherlands)

    de Vries, H.J.C.; Smelov, V.; Middelburg, J.G.; Pleijster, J.; Speksnijder, A.G.; Morré, S.A.

    2009-01-01

    Microbial cure of chlamydia proctitis (lymphogranuloma venereum [LGV] and non-LGV) with doxycycline treatment was evaluated by chlamydia DNA and RNA persistence in anal swab specimens. In LGV proctitis, RNA persisted for up to 16 days. In non-LGV chlamydia proctitis, DNA was undetectable after 7

  17. Radiation proctitis and its surgical problems

    Energy Technology Data Exchange (ETDEWEB)

    Ichikawa, Hideyuki; Hayashi, Shiro; Yasuna, Osamu; Yamaura, Yoshinori

    1985-01-01

    Radiation proctitis was investigated in terms of clinico-pathological findings, the method of treatment and therapeutic results in 11 patients (7 with cervical cancer, 1 with ovarian cancer, and 3 with cancer of the bladder). Four of the patients with cervical cancer were treated with 4,136-5,000 rad of WCo combined with brachytherapy of WCo or TXCs, one patient with 6,000 rad of WCo alone, one with 3,000 rad of x-ray alone, and one with 4,900 rad of x-ray combined with brachytherapy of TXCs. A patient with ovarian cancer was treated with 6,000 rad of x-ray and three patients with cancer of the bladder were treated with 4,200-6,330 rad of x-ray. Radiation proctitis developed early (4 months to 1 year after therapy) in 8 patients and late (4 years to 19 years after therapy) in the other 3 patients. Common symptoms were melena, constipation and sensation of gastric fullness. According to the Sherman's classification, proctitis was grade III or IV (showing constriction, ulcer or fistula) in all patients. Although the lesion could be resected in one patient, only colostomy was performed in the other 10 patients. It is recommended that care should be taken in deciding the method of exposure to the pelvic viscera and exposure doses for the prevention of radiation proctitis, and that intestinal lesions should be resected before far-advanced intestinal disturbance developes. (Namekawa, K.).

  18. Fatal hæmofagocytisk lymfohistiocytose og mononukleose hos en patient med colitis ulcerosa

    DEFF Research Database (Denmark)

    Juul Ingvardsen, Charlotte; Ballegaard, Vibe Cecilie; Homøe, Preben

    2012-01-01

    We report a case of Epstein-Barr virus primo infection with the development of lethal haemophagocytic lymphohistiocytosis (HLH) in a 22 year-old man, who was being treated with azathioprin for colitis ulcerosa. HLH is a rare, life-threatening disease, which is caused by an inappropriate activation...

  19. Fatal hæmofagocytisk lymfohistiocytose og mononukleose hos en patient med colitis ulcerosa

    DEFF Research Database (Denmark)

    Juul Ingvardsen, Charlotte; Ballegaard, Vibe Cecilie; Homøe, Preben

    2012-01-01

    We report a case of Epstein-Barr virus primo infection with the development of lethal haemophagocytic lymphohistiocytosis (HLH) in a 22 year-old man, who was being treated with azathioprin for colitis ulcerosa. HLH is a rare, life-threatening disease, which is caused by an inappropriate activatio...

  20. Endocarditis infecciosa activa: 152 casos

    Directory of Open Access Journals (Sweden)

    Lucía R. Kazelian

    2012-04-01

    Full Text Available La endocarditis infecciosa es una enfermedad de baja incidencia que en las últimas décadas mostró modificaciones respecto de su presentación, posibilidad diagnóstica y tratamiento. A pesar de estos avances, la mortalidad hospitalaria sigue siendo muy elevada. Nuestro objetivo fue analizar las características de los pacientes con endocarditis infecciosa activa y su relación con la mortalidad hospitalaria a lo largo de 16 años. Se realizó un registro prospectivo entre 1994 y 2010 de pacientes ingresados con endocarditis. Se analizaron características clínicas, evolución y tratamiento y se registraron los eventos intrahospitalarios. Ingresaron 152 pacientes, 64.5% varones, edad 45 ± 16 años, las causas más frecuentes de cardiopatía de base fueron: congénita 32 (21% y reumática 20 (13.2%. Los motivos de internación fueron síndrome febril 116 (76.3% e insuficiencia cardíaca 61 (40.1%. Se identificó el agente infeccioso en 106 (69.7% de los casos, el más frecuente fue Streptococcus viridans. El ecocardiograma mostró vegetaciones en 123 (80.9% de los pacientes y 88 (57.8% presentaron complicaciones durante su internación, siendo la más frecuente la insuficiencia cardíaca. Se indicó tratamiento quirúrgico en 96 (63.1% de los casos, fundamentalmente por insuficiencia cardíaca en 66. La mortalidad hospitalaria global fue 46 (30.2%. El desarrollo de complicaciones en la internación, la indicación de cirugía y la presencia de insuficiencia cardíaca refractaria al tratamiento fueron predictores independientes de mortalidad hospitalaria, mientras que la presencia de vegetaciones resultó un predictor independiente de mejor supervivencia. La identificación temprana de estos predictores descriptos podría ayudar a mejorar los resultados.

  1. Metabolismo de los hidratos de carbono en los enterocitos de sujetos con enfermedad de Crohn y colitis ulcerosa.

    OpenAIRE

    Estada Gimeno, Úrsula

    2007-01-01

    RESUMEN Introducción: Los pacientes con enfermedad inflamatoria crónica intestinal (EII), enfermedad de Crohn y colitis ulcerosa presentan lesiones en el epitelio intestinal de carácter inflamatorio. Estas lesiones afectan al intestino grueso en la colitis ulcerosa y a cualquier parte del tracto digestivo en la enfermedad de Crohn. En este tipo de enfermos se ha visto que existe una menor absorción de nutrientes, sobre todo en la enfermedad de Crohn, entre ellos la lactosa (el azúcar de la...

  2. Periostal hypertrophic osteopathy of bones (long bones) in colitis ulcerosa in adolescents

    International Nuclear Information System (INIS)

    Bargon, G.; Arlart, I.

    1982-01-01

    The article reports on a 14-year old girl with periostal new formation of bones at the long bones of the lower arms, the femora and the lower legs the individual phalanges and metacarpalia after colitis ulcerosa which had lasted for several years and had progressed stagewise. After a clinically recorded new attack the periostal new formations of bone progressed. Some time after the last attack of colitis the periostal changes in the bones partially receded. The article discusses the hypothetic explanations aiming at interpreting the pathogenesis of hypertrophic osteoarthropathies and periostoses, as given in the literature. (orig.) [de

  3. Periostal hypertrophic osteopathy of bones (long bones) in colitis ulcerosa in adolescents

    Energy Technology Data Exchange (ETDEWEB)

    Bargon, G.; Arlart, I.

    1982-03-01

    The article reports on a 14-year old girl with periostal new formation of bones at the long bones of the lower arms, the femora and the lower legs the individual phalanges and metacarpalia after colitis ulcerosa which had lasted for several years and had progressed stagewise. After a clinically recorded new attack the periostal new formations of bone progressed. Some time after the last attack of colitis the periostal changes in the bones partially receded. The article discusses the hypothetic explanations aiming at interpreting the pathogenesis of hypertrophic osteoarthropathies and periostoses, as given in the literature.

  4. Clinical and experimental studies on radiation proctitis

    International Nuclear Information System (INIS)

    Honke, Yoshifumi

    1988-01-01

    Clinical and experimental studies were performed to clarify the mechanism of developing radiation proctitis. The results were as follows; (1) In the clinical study with 38 uterine cervix cancer patients, who received radiotherapy, diarrhea was observed in 44.7% at the acute stage, while rectal bleeding in 36.7% about 1 year after radiation. However, no clinical correlation was observed between diarrhea and rectal bleeding. (2) Colon fiberscopic examination revealed little change at the acute stage. However, erosion, ulcer and remarkable redness were found at the late stage. By the magnified fiberscope, unit degeneration was found in 72.8% at the acute stage. (3) Concerning the histopathological changes, edema and inflammatory change were observed immediately after irradiation. Fibrosis was observed in 83.3% at the late stage. (4) The number of the immunoglobulin containing cells decreased by radiation. However, its recovered as time passed after radiation. (5) In experimental study with rats by microangiography, there were ramarkable changes of the small vessels, such as bending, tortuosity and capillary hyperplasia at the acute stage. However, these changes returned to normal soon. At the late stage, decreased number of blood vessels were observed. The above results indicated that rectal bleeding after exposure to radiation are developed by secondary circulation abnormality caused by fibrosis of the perivascular tissues. (author) 52 refs

  5. Impacto del cigarrillo en el tracto gastrointestinal: Efecto diferencial en Enfermedad de Crohn y Colitis Ulcerosa

    Directory of Open Access Journals (Sweden)

    Loni Berkowitz Fiebich

    2017-03-01

    Full Text Available El impacto del consumo de cigarrillo a nivel respiratorio y cardiovascular ha sido extensamente investigado, sin embargo, aún queda mucho por estudiar sobre su impacto en el tracto gastrointestinal. Está demostrado que el tabaquismo es un importante factor de riesgo para desórdenes gastrointestinales, incluyendo úlceras pépticas, Enfermedad de Crohn y distintos tipos de cáncer. Los mecanismos propuestos incluyen daños a nivel de la mucosa, alteraciones en la irrigación del tejido y cambios en la respuesta inmune. Paradojalmente, el consumo de cigarrillo constituye un factor protector para el desarrollo y la progresión de la Colitis Ulcerosa. Esta patología, junto a la Enfermedad de Crohn, conforman las dos entidades más importantes dentro de las Enfermedades Inflamatorias Intestinales y comparten diversas características. El impacto diferencial del consumo de cigarrillo entre ambas ha sido un tema de gran interés en los últimos treinta años, y aún no ha logrado ser esclarecido. En esta revisión describiremos los efectos conocidos del tabaquismo sobre el tracto gastrointestinal, y particularmente en la inflamación intestinal, profundizando en los estudios disponibles que intentan explicar el efecto opuesto del cigarrillo en la Enfermedad de Crohn y la Colitis Ulcerosa

  6. Infliximab induces clinical, endoscopic and histological responses in refractory ulcerative colitis Infliximab induce respuesta clínica, endoscópica e histológica en la colitis ulcerosa refractaria

    Directory of Open Access Journals (Sweden)

    F. Bermejo

    2004-02-01

    Full Text Available Background: infliximab is a monoclonal antiTNF-α antibody that has repeatedly shown to be effective in the management of Crohn's disease. However, data are scarce about its efficacy in ulcerative colitis. Aim: to describe the joint experience of three Spanish hospitals in the use of infliximab in patients with active refractory ulcerative colitis. Patients and methods: we present seven cases of ulcerative colitis (6 with chronic active disease despite immunosuppressive therapy, and one with acute steroid-refractory ulcerative colitis treated with infliximab 5 mg/kg of body weight. Clinical response was evaluated by means of the Clinical Activity Index at 2, 4 and 8 weeks after initial infusion. Biochemical (erythrocyte sedimentation rate and C-reactive protein, endoscopic, and histological changes were also assessed. Results: mean age of patients was 45.8 ± 17 years (range 23-77; 4 were female. No adverse effects were recorded. Inflammatory activity diminished significantly in 6 of 7 patients (85.7%; CI 95%: 42-99% both from a clinical (p = 0.01 and biochemical (p Introducción: infliximab, un anticuerpo monoclonal quimérico antiTNF-α ha demostrado su eficacia en pacientes con enfermedad de Crohn. Sin embargo, son escasos los datos sobre su efectividad en el tratamiento de la colitis ulcerosa. Objetivo: describir la experiencia conjunta de 3 hospitales españoles en el uso de infliximab en enfermos con CU activa resistente a otros tratamientos. Pacientes y métodos: se presentan 7 casos de colitis ulcerosa (6 con enfermedad crónicamente activa a pesar de tratamiento con inmunosupresor y 1 con colitis aguda grave refractaria a esteroides tratados con infliximab a dosis de 5 mg/kg de peso. Se evaluó la respuesta clínica mediante un Índice de Actividad Clínica trascurridas 2, 4 y 8 semanas de la infusión inicial. Así mismo, se estudiaron los cambios analíticos (velocidad de sedimentación y proteína C reactiva, endoscópicos e histol

  7. Políticas activas en las prestaciones por desempleo

    OpenAIRE

    Gil Jiménez, Javier

    2016-01-01

    El presente trabajo explica el tema de las políticas activas y políticas activas en las prestaciones por desempleo, tanto a nivel nacional como internacional. Para explicarlo se definen las políticas activas y sus funciones, tanto de formación, orientación y reinserción laboral. También se hace mención a las reformas llevadas a cabo en las diferentes políticas y el surgimiento de nuevos programas como función de políticas activas encaminadas a la reinserción laboral. Departamento de Derech...

  8. Acute radiation proctitis. A clinical, histopathological and histochemical study

    International Nuclear Information System (INIS)

    Hovdenak, Nils

    2004-01-01

    The aim of the study is: 1) A sequential description of the clinical course of acute radiation proctitis during pelvic RT. 2) A sequential description of the rectal mucosal histopathology during pelvic RT as a possible substrate for clinical toxicity. 3) To assess the mucosal protease activity during RT as a possible explanation of the observed tissue changes. 4) To assess the efficacy of prophylactic sucralfate in acute radiation proctitis a randomised study was initiated and carried out together with a meta-analysis of previously available data. 5) Most studies on clinical acute toxicity in pelvic RT use either the RTOG/EORTC score system or focus on diarrhoea/stool frequency. A more differentiated and sensitive recording was developed and tested to pick up symptoms escaping the commonly used scores. 6) Study the relation between histopathological findings and the clinical picture. 4 papers presenting various studies are included. The titles are: 1) Acute radiation proctitis: a sequential clinicopathologic study during pelvic radiotherapy. 2) Clinical significance of increased gelatinolytic activity in the rectal mucosa during external beam radiation therapy of prostate cancer. 3) Profiles and time course of acute radiation toxicity symptoms during conformal radiotherapy for cancer of the prostate. 4) Sucralfate does not ameliorate acute radiation proctitis. Some future prospects are discussed

  9. Formalin treatment of radiation-induced hemorrhagic proctitis

    International Nuclear Information System (INIS)

    Rubinstein, E.; Ibsen, T.; Rasmussen, R.B.; Reimer, E.; Sorensen, B.L.

    1986-01-01

    A 71-year-old man developed severe hemorrhagic proctitis 1 year after pelvic irradiation for carcinoma of the urinary bladder. Conservative treatment as well as performance of a colostomy failed to control the rectal bleeding. After irrigation of the rectum with a formalin solution the bleeding stopped, and no recurrence has been observed for the next 14 months

  10. Acute radiation proctitis. A clinical, histopathological and histochemical study

    Energy Technology Data Exchange (ETDEWEB)

    Hovdenak, Nils

    2004-07-01

    The aim of the study is: 1) A sequential description of the clinical course of acute radiation proctitis during pelvic RT. 2) A sequential description of the rectal mucosal histopathology during pelvic RT as a possible substrate for clinical toxicity. 3) To assess the mucosal protease activity during RT as a possible explanation of the observed tissue changes. 4) To assess the efficacy of prophylactic sucralfate in acute radiation proctitis a randomised study was initiated and carried out together with a meta-analysis of previously available data. 5) Most studies on clinical acute toxicity in pelvic RT use either the RTOG/EORTC score system or focus on diarrhoea/stool frequency. A more differentiated and sensitive recording was developed and tested to pick up symptoms escaping the commonly used scores. 6) Study the relation between histopathological findings and the clinical picture. 4 papers presenting various studies are included. The titles are: 1) Acute radiation proctitis: a sequential clinicopathologic study during pelvic radiotherapy. 2) Clinical significance of increased gelatinolytic activity in the rectal mucosa during external beam radiation therapy of prostate cancer. 3) Profiles and time course of acute radiation toxicity symptoms during conformal radiotherapy for cancer of the prostate. 4) Sucralfate does not ameliorate acute radiation proctitis. Some future prospects are discussed.

  11. Aspectos psicopatológicos en la enfermedad de Crohn y en la colitis ulcerosa

    Directory of Open Access Journals (Sweden)

    Stefano Vinaccia

    2007-06-01

    Full Text Available son trastornos crónicos que inflaman y destruyen el tejido intestinal de forma periódica y recurrente. Las EII se clasifican en dos tipos: enfermedad de Crohn (EC y colitis ulcerosa (CU. La etiología tanto de la EC como de la CU es poco conocida y el curso está influido por múltiples factores de tipo biopsicosocial. Al respecto, diversas investigaciones están aportando evidencia de la implicación de factores psicológicos en el curso de las EII, tales como el estrés psicosocial, las estrategias de afrontamiento, las características de personalidad, los síntomas psicopatológicos y el apoyo social

  12. Aspectos psicopatológicos en la enfermedad de Crohn y en la colitis ulcerosa

    Directory of Open Access Journals (Sweden)

    Sergio Tobón

    2010-07-01

    Full Text Available Las enfermedades inflamatorias del intestino (EII son trastornos crónicos que inflaman y destruyen el tejido intestinal de forma periódica y recurrente. Las EII se clasifican en dos tipos: enfermedad de Crohn (EC y colitis ulcerosa (CU. La etiología tanto de la EC como de la CU es poco conocida y el curso está influido por múltiples factores de tipo biopsicosocial. Al respecto, diversas investigaciones están aportando evidencia de la implicación de factores psicológicos en el curso de las EII, tales como el estrés psicosocial, las estrategias de afrontamiento, las características de personalidad, los síntomas psicopatológicos y el apoyo social.

  13. Colitis ulcerosa

    DEFF Research Database (Denmark)

    Nielsen, Ole Haagen; Jess, Tine; Bjerrum, Jacob Tveiten

    2013-01-01

    Ulcerative colitis (UC) is a prevalent inflammatory bowel disease of the colonic mucosa affecting approximately 20,000-25,000 Danes. Apart from subgroups with early onset, extensive and long-standing inflammation, or primary sclerosing cholangitis the risk of developing colorectal cancer is of th......Ulcerative colitis (UC) is a prevalent inflammatory bowel disease of the colonic mucosa affecting approximately 20,000-25,000 Danes. Apart from subgroups with early onset, extensive and long-standing inflammation, or primary sclerosing cholangitis the risk of developing colorectal cancer...... is of the same magnitude as in the background population. The symptoms are usually diarrhoea including bloody stools, rectal tenesmi, anaemia, and fatigue. This review is an update on diagnostics and treatment strategies of relevance for clinicians, and as UC often affects patients during their peak reproductive...

  14. Effect of pentoxifylline and tocopherol on radiation proctitis/enteritis

    International Nuclear Information System (INIS)

    Hille, A.; Christiansen, H.; Pradier, O.; Hermann, R.M.; Siekmeyer, B.; Weiss, E.; Hess, C.F.; Schmidberger, H.; Hilgers, R.

    2005-01-01

    Background and purpose: Chronic radiation proctitis/enteritis is a relevant complication of pelvic irradiation, which is still mainly treated by supportive measures only. There is some evidence that the combined treatment with pentoxifylline and tocopherol might alter the pathogenesis of radiation-induced fibrosis. In a retrospective analysis the clinical benefit of the treatment with pentoxifylline/tocopherol on radiation-induced proctitis/enteritis was evaluated, compared to supportive care only. Patients and methods: Of 30 patients with radiation-induced proctitis/enteritis grade I-II according to the RTOG/EORTC toxicity criteria, 21 were treated with pentoxifylline and tocopherol. Depending on physician's decision nine patients received symptomatic treatment only. Results: With pentoxifylline/tocopherol treatment 15/21 patients (71%) experienced a relief of their symptoms. A reduction from grade I/II to grade 0 toxicity was observed in seven and from grade II to grade I toxicity in eight patients. No improvement was seen in six patients. The median time to improvement with pentoxifylline and tocopherol treatment was 28 weeks. In three of nine patients who were treated supportively only, deterioration of symptoms occurred. Three patients experienced no amelioration, and three patients with grade I toxicity experienced a spontaneous relief of their symptoms (33%). Conclusion: The combination treatment with pentoxifylline and tocopherol seems to have a benefit in patients with grade I-II radiation-induced proctitis/enteritis. The optimal schedule of treatment duration is not yet clear. From the observations made in this study it is assumed the treatment should be given for 6-12 months at least. A prospective phase II study should be undertaken to evaluate optimal treatment duration. (orig.)

  15. Effect of pentoxifylline and tocopherol on radiation proctitis/enteritis

    Energy Technology Data Exchange (ETDEWEB)

    Hille, A.; Christiansen, H.; Pradier, O.; Hermann, R.M.; Siekmeyer, B.; Weiss, E.; Hess, C.F.; Schmidberger, H. [Goettingen Univ. (Germany). Dept. of Radiotherapy and Radiation; Hilgers, R. [Goettingen Univ. (Germany). Dept. for Medical Statisics

    2005-09-15

    Background and purpose: Chronic radiation proctitis/enteritis is a relevant complication of pelvic irradiation, which is still mainly treated by supportive measures only. There is some evidence that the combined treatment with pentoxifylline and tocopherol might alter the pathogenesis of radiation-induced fibrosis. In a retrospective analysis the clinical benefit of the treatment with pentoxifylline/tocopherol on radiation-induced proctitis/enteritis was evaluated, compared to supportive care only. Patients and methods: Of 30 patients with radiation-induced proctitis/enteritis grade I-II according to the RTOG/EORTC toxicity criteria, 21 were treated with pentoxifylline and tocopherol. Depending on physician's decision nine patients received symptomatic treatment only. Results: With pentoxifylline/tocopherol treatment 15/21 patients (71%) experienced a relief of their symptoms. A reduction from grade I/II to grade 0 toxicity was observed in seven and from grade II to grade I toxicity in eight patients. No improvement was seen in six patients. The median time to improvement with pentoxifylline and tocopherol treatment was 28 weeks. In three of nine patients who were treated supportively only, deterioration of symptoms occurred. Three patients experienced no amelioration, and three patients with grade I toxicity experienced a spontaneous relief of their symptoms (33%). Conclusion: The combination treatment with pentoxifylline and tocopherol seems to have a benefit in patients with grade I-II radiation-induced proctitis/enteritis. The optimal schedule of treatment duration is not yet clear. From the observations made in this study it is assumed the treatment should be given for 6-12 months at least. A prospective phase II study should be undertaken to evaluate optimal treatment duration. (orig.)

  16. Ulcerative proctitis: an update on the pharmacotherapy and management.

    Science.gov (United States)

    Gecse, Krisztina B; Lakatos, Peter L

    2014-08-01

    Ulcerative colitis (UC) presents as proctitis in approximately a quarter of the patients. It may progress into left-sided or extensive colitis in up to 50% of cases upon long-term follow-up. Currently available data on ulcerative proctitis are summarized and critically reviewed. Extensive literature search (MEDLINE) was performed to identify relevant articles up to March 2014. The short-term goal of the treatment in UC is to induce remission, whereas long-term goals are to maintain remission and prevent disease progression. Topically administered 5-aminosalicylates (5-ASA) and corticosteroids are effective in the treatment of proctitis, although they seem to be underused in everyday practice. Locally administered 5-ASA preparations are more effective than oral compounds. The combination of topical and oral 5-ASA and steroids should be considered for escalation of treatment. Refractory patients should be re-evaluated to exclude for compliance failures, infections or proximal disease extent. True refractory or steroid-dependent patients may require immunomodulators or biological therapy. Alternative medicine can be used complementarily, while experimental approaches are reserved for patients failing conventional medication. Proctocolectomy may be the last resort of treatment. Upon long-term, 5-ASA maintenance treatment is indicated in all UC cases to prevent relapse and disease progression.

  17. 2013 European Guideline on the management of proctitis, proctocolitis and enteritis caused by sexually transmissible pathogens

    NARCIS (Netherlands)

    de Vries, Henry J. C.; Zingoni, Adele; White, John A.; Ross, Jonathan D. C.; Kreuter, Alexander

    2014-01-01

    Proctitis is defined as an inflammatory syndrome of the distal 10-12 cm of the anal canal, also called the rectum. Infectious proctitis can be sexually transmitted via genital-anal mucosal contact, but some also via mutual masturbation.N. gonorrhoeae,C. trachomatis(including lymphogranuloma

  18. Hyperbaric Oxygen Therapy for Radiation-Induced Cystitis and Proctitis

    International Nuclear Information System (INIS)

    Oliai, Caspian; Fisher, Brandon; Jani, Ashish; Wong, Michael; Poli, Jaganmohan; Brady, Luther W.; Komarnicky, Lydia T.

    2012-01-01

    Purpose: To provide a retrospective analysis of the efficacy of hyperbaric oxygen therapy (HBOT) for treating hemorrhagic cystitis (HC) and proctitis secondary to pelvic- and prostate-only radiotherapy. Methods and Materials: Nineteen patients were treated with HBOT for radiation-induced HC and proctitis. The median age at treatment was 66 years (range, 15–84 years). The range of external-beam radiation delivered was 50.0–75.6 Gy. Bleeding must have been refractory to other therapies. Patients received 100% oxygen at 2.0 atmospheres absolute pressure for 90–120 min per treatment in a monoplace chamber. Symptoms were retrospectively scored according to the Late Effects of Normal Tissues—Subjective, Objective, Management, Analytic (LENT-SOMA) scale to evaluate short-term efficacy. Recurrence of hematuria/hematochezia was used to assess long-term efficacy. Results: Four of the 19 patients were lost to follow-up. Fifteen patients were evaluated and received a mean of 29.8 dives: 11 developed HC and 4 proctitis. All patients experienced a reduction in their LENT-SOMA score. After completion of HBOT, the mean LENT-SOMA score was reduced from 0.78 to 0.20 in patients with HC and from 0.66 to 0.26 in patients with proctitis. Median follow-up was 39 months (range, 7–70 months). No cases of hematuria were refractory to HBOT. Complete resolution of hematuria was seen in 81% (n = 9) and partial response in 18% (n = 2). Recurrence of hematuria occurred in 36% (n = 4) after a median of 10 months. Complete resolution of hematochezia was seen in 50% (n = 2), partial response in 25% (n = 1), and refractory bleeding in 25% (n = 1). Conclusions: Hyperbaric oxygen therapy is appropriate for radiation-induced HC once less time-consuming therapies have failed to resolve the bleeding. In these conditions, HBOT is efficacious in the short and long term, with minimal side effects.

  19. Vulnerabilidad al estrés en pacientes con enfermedad ulcerosa péptica

    Directory of Open Access Journals (Sweden)

    David Pérez Núñez

    Full Text Available Introducción: el estrés es considerado una reacción o respuesta no específica del organismo o cualquier cambio engendrado en este por el impacto de acontecimientos importantes. Método: se realizó una investigación descriptiva, correlacional, de corte transversal y cuantitativa, con un diseño no experimental con el. Objetivo: de evaluar la vulnerabilidad al estrés en una muestra seleccionada de manera intencional de 70 sujetos, todos diagnosticados con enfermedad ulcerosa péptica, por endoscopias recientes (menos de seis meses, que asistieron a la consulta de Gastroenterología del Policlínico "Efraín Mayor" del municipio Cotorro, en el periodo de enero a marzo de 2013. Resultados: se encontró que el 85,7% de la muestra son no vulnerables al estrés, predominó el sexo femenino en el estudio, siendo el tabaco y el café los hábitos tóxicos más frecuentes en la población estudiada. La ansiedad como rasgo y como estado, predominaron a un nivel bajo y medio. Conclusiones: se recomendó repetir estudio similar en otra área de salud del municipio Cotorro y otros estudios con variables: Estilos de vida, afrontamientos y apoyo social, en su relación a la vulnerabilidad al estrés, además de realizar estrategia de intervención educativa en los pacientes estudiados.

  20. Lymphogranuloma venereum proctitis: a differential diagnose to inflammatory bowel disease.

    Science.gov (United States)

    Høie, Sverre; Knudsen, Lene Surland; Gerstoft, Jan

    2011-04-01

    Lymphogranuloma venereum (LGV) is a sexually transmitted disease, endemic in tropical and subtropical areas for many years. After 2003 there have been several outbreaks in western countries, especially among HIV-positive men who have sex with men (MSM). An important manifestation of LGV is a proctitis, with a clinical presentation and endoscopic findings resembling those of inflammatory bowel diseases (IBDs). LGV is considered new in Scandinavia. This case report focuses on difficulties in differentiating LGV and IBD. This case report used a systematic search in the literature using PubMed and clinical cases from the Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet, Denmark (Cases 1-3) and the Section of Surgery, Hamar Hospital, Norway (Case 4). Clinical and endoscopic findings in LGV and IBD resemble each other. All cases were MSM. Three out of four were HIV-positive. Three out of four contacted their general practitioner (GP) due to gastrointestinal (GI) symptoms, and were referred to a gastroenterologist (GE) with suspicion of IBD. Because of non-successful IBD treatment, control of HIV status, relapses of GI-symptoms or extended information concerning sexual habits, LGV was suspected and diagnosed. All patients responded with remission of GI-symptoms and endoscopic findings after oral treatment with doxycycline. Due to similarities between LGV and IBD, LGV should be considered as a differential diagnosis in patients with proctitis or IBD-related symptoms, especially among HIV-positive men. Hence LGV patients may be spared long-lasting examination, mistreatment and surgery.

  1. Lymphogranuloma venereum proctitis: A differential diagnose to inflammatory bowel disease

    DEFF Research Database (Denmark)

    Høie, Sverre; Knudsen, Lene Surland; Gerstoft, Jan

    2011-01-01

    each other. All cases were MSM. Three out of four were HIV-positive. Three out of four contacted their general practitioner (GP) due to gastrointestinal (GI) symptoms, and were referred to a gastroenterologist (GE) with suspicion of IBD. Because of non-successful IBD treatment, control of HIV status...... as a differential diagnosis in patients with proctitis or IBD-related symptoms, especially among HIV-positive men. Hence LGV patients may be spared long-lasting examination, mistreatment and surgery.......Abstract Objective. Lymphogranuloma venereum (LGV) is a sexually transmitted disease, endemic in tropical and subtropical areas for many years. After 2003 there have been several outbreaks in western countries, especially among HIV-positive men who have sex with men (MSM). An important...

  2. POLÍTICAS ACTIVAS DE EMPLEO PARA CALI-COLOMBIA

    Directory of Open Access Journals (Sweden)

    Carlos Giovanni González Espitia

    2011-01-01

    Full Text Available El artículo discute la implementación de políticas activas de empleo para el mercado laboral en Cali-Colombia. El principal objetivo de una política activa de empleo es la reducción de la tasa de desempleo, la reducción de la participación en la informalidad y el reemplazo de trabajos malos o de baja calidad por trabajos buenos. La acción colectiva de las instituciones regionales públicas, los empresarios regionales y las instituciones académicas es fundamental para alcanzar empleo de alta calidad en la ciudad.

  3. EORTC radiation proctitis-specific quality of life module - Pretesting in four European countries

    International Nuclear Information System (INIS)

    Halkett, Georgia; Aoun, Samar; Hayne, Dickon; Lund, Jo-Asmund; Gruen, Arne; Villa, Julie; Livi, Lorenzo; Arcangeli, Stefano; Velikova, Galina; Spry, Nigel

    2010-01-01

    Background and purpose: Radiation proctitis is a side effect which can occur after pelvic radiation therapy. Currently available questionnaires do not comprehensively assess the range of problems, nor impact on quality of life associated with proctitis. This article reports on the cultural testing phase of an EORTC module (QLQ-PRT21) developed to assess radiation proctitis specific issues and designed to be used in conjunction with the EORTC core quality of life questionnaire (QLQ-C30). Methods: The previously developed 21-item module, pre-tested in Australia, was translated into Norwegian, German, French and Italian. Patients completed the EORTC QLQ-C30 and module questionnaires towards the end of their radical pelvic radiation treatment to target acute side effects. Patients experiencing chronic proctitis were also surveyed. Patients also participated in structured interviews to determine issues of comprehensibility, coverage and relevance. Results were compared with Australian data. Results: Questionnaires were completed by 64 European patients. The module was found to be relevant and culturally acceptable to participants. Feedback has led to minor translation modifications and the inclusion of two additional questions. Conclusion: This module is ready for Phase IV testing which will consist of large scale field testing with the aim to perform psychometric analysis and finalise a module that will be suitable in the assessment of radiation induced proctitis.

  4. Long-term sequential changes of radiation proctitis and angiopathy in rats

    International Nuclear Information System (INIS)

    Doi, Hiroshi; Kamikonya, Norihiko; Takada, Yasuhiro

    2012-01-01

    The purpose of the present study was to establish an experimental rat model for late radiation proctitis, and to examine the assessment strategy for late radiation proctitis. A total of 57 Wistar rats were used. Forty-five of the rats were exposed to selective rectal irradiation with a single fraction of 25 Gy. These rats were sacrificed at the 4th, 12th, 24th, and 37th week following irradiation. The remaining 12 rats comprised the control group without irradiation. The rectal mucosa of each rat was evaluated macroscopically and pathologically. The number of vessels in the rectal mucosa was counted microscopically. In addition, the vascular stenosis was evaluated. In the results, the degree of clinical and macroscopic findings decreased following acute proctitis and developed later. In the pathological examination, mucosal changes and microangiopathy were followed up, as well. The absolute number of vessels in the rectum was the greatest at the 12th week following irradiation and was the lowest in the control group. The severity of the microangiopathy was also well evaluated. To conclude, we established an animal experimental model of late radiation proctitis, and also established an assessment strategy to evaluate objectively the severity of late radiation proctitis with focusing on microangiopathy using an animal experimental model. This model can be used as an animal experimental model of radiation-induced microangiopathy. (author)

  5. Endoscopic diode laser therapy for chronic radiation proctitis.

    Science.gov (United States)

    Polese, Lino; Marini, Lucia; Rizzato, Roberto; Picardi, Edgardo; Merigliano, Stefano

    2018-01-01

    The purpose of this study is to determine the effectiveness of endoscopic diode laser therapy in patients presenting rectal bleeding due to chronic radiation proctitis (CRP). A retrospective analysis of CRP patients who underwent diode laser therapy in a single institution between 2010 and 2016 was carried out. The patients were treated by non-contact fibers without sedation in an outpatient setting. Fourteen patients (median age 77, range 73-87 years) diagnosed with CRP who had undergone high-dose radiotherapy for prostatic cancer and who presented with rectal bleeding were included. Six required blood transfusions. Antiplatelet (three patients) and anticoagulant (two patients) therapy was not suspended during the treatments. The patients underwent a median of two sessions; overall, a mean of 1684 J of laser energy per session was used. Bleeding was resolved in 10/14 (71%) patients, and other two patients showed improvement (93%). Only one patient, who did not complete the treatment, required blood transfusions after laser therapy; no complications were noted during or after the procedures. Study findings demonstrated that endoscopic non-contact diode laser treatment is safe and effective in CRP patients, even in those receiving antiplatelet and/or anticoagulant therapy.

  6. Clinical studies in the effect of sodium alginate on radiation esophagitis and proctitis

    Energy Technology Data Exchange (ETDEWEB)

    Adachi, Hideki; Ono, Koji; Abe, Mitsuyuki; Inoue, Toshihiko; Imura, Toshio; Onoyama, Yasuto; Tanaka, Yoshimasa; Narabayashi, Isamu; Yoshikawa, Yuichi

    1985-04-01

    In the present study, we examined the effect of sodium alginate, a drug which has been used for the treatment of peptic ulcer, on radiation esophagitis or proctitis. Over seventy percent of patients suffered from swallowing pain due to radiation esophagitis were relieved from the pain within a week after an oral administration of sodium alginate. The extent of the improvement of the symptom did not significantly correlate with sex and age of the patients and with radiation doses delivered before occurrence of swallowing pain. For the treatment of radiation proctitis, an anal administration of sodium alginate was also effective. Melena, a major symptom of radiation proctitis, was decreased or disappeared in seventeen out of nineteen cases. The durations required for the improvement of melena varied from seven to seventy days. Endoscopical examinations of the rectum revealed reparation of erosions on the mucosal surface in parallel with the improvement of melena. (author).

  7. Failure of 5-aminosalicylic acid enemas to improve chronic radiation proctitis

    International Nuclear Information System (INIS)

    Baum, C.A.; Biddle, W.L.; Miner, P.B. Jr.

    1989-01-01

    Radiation proctitis is a well-known complication of abdominal and pelvic radiation. Conventional medical and surgical treatment often is disappointing. 5-Aminosalicylic acid (5-ASA) is the active component in sulfasalazine and is effective in the treatment of distal ulcerative colitis. Four patients with radiation proctitis were treated with 4 g 5-ASA by enema nightly for two to six months. Patients were seen monthly, interviewed, and a sigmoidoscopic exam performed. No change was seen in the degree of mucosal inflammation on follow-up sigmoidoscopic exams. Three patients noted no change in their symptoms of bleeding, pain, or tenesmus. One patient noted initial improvement, but this was not sustained. 5-ASA enemas do not appear to be effective in the treatment of radiation proctitis

  8. Can Angiotensin-Converting Enzyme Inhibitors Reduce the Incidence, Severity, and Duration of Radiation Proctitis?

    International Nuclear Information System (INIS)

    Alashkham, Abduelmenem; Paterson, Catherine; Rauchhaus, Petra; Nabi, Ghulam

    2016-01-01

    Purpose: To determine whether participants taking angiotensin-converting enzyme inhibitors (ACEIs) and treated with radical radiation therapy with neoadjuvant/adjuvant hormone therapy have less incidence, severity, and duration of radiation proctitis. Methods and Materials: A propensity score analysis of 817 patients who underwent radical radiation therapy with neoadjuvant or adjuvant hormone therapy as primary line management in a cohort study during 2009 to 2013 was conducted. Patients were stratified as follows: group 1, hypertensive patients taking ACEIs (as a study group); group 2, nonhypertensive patients not taking ACEIs; and group 3, hypertensive patients not taking ACEIs (both as control groups). The incidence, severity, and duration of proctitis were the main outcome. χ"2 tests, Mann-Whitney U tests, analysis of variance, risk ratio (RR), confidence interval (CI), Kaplan-Meier plots, and log-rank tests were used. Results: The mean age of the participants was 68.91 years, with a follow-up time of 3.38 years. Based on disease and age-matched comparison, there was a statistically significant difference of proctitis grading between the 3 groups: χ"2 (8, n=308) = 72.52, P<.001. The Mann-Whitney U test indicated that grades of proctitis were significantly lower in hypertensive patients taking ACEIs than in nonhypertensive patients not taking ACEIs and hypertensive patients not taking ACEIs (P<.001). The risk ratio (RR) of proctitis in hypertensive patients taking ACEIs was significantly lower than in hypertensive patients not taking ACEIs (RR 0.40, 95% CI 0.30-0.53, P<.001) and in nonhypertensive patients not taking ACEIs (RR 0.58, 95% CI 0.44-0.77, P<.001). Time to event analysis revealed that hypertensive patients taking ACEIs were significantly different from the control groups (P<.0001). Furthermore, hypertensive patients taking ACEIs had significantly faster resolution of proctitis (P<.0001). Conclusion: Patients who were taking ACEIs were

  9. Can Angiotensin-Converting Enzyme Inhibitors Reduce the Incidence, Severity, and Duration of Radiation Proctitis?

    Energy Technology Data Exchange (ETDEWEB)

    Alashkham, Abduelmenem, E-mail: alashkham@yahoo.com [Academic Section of Urology, Division of Cancer Research, School of Medicine, University of Dundee, Scotland (United Kingdom); Paterson, Catherine [Academic Section of Urology, Division of Cancer Research, School of Medicine, University of Dundee, Scotland (United Kingdom); Rauchhaus, Petra [Tayside Clinical Trials Unit, School of Medicine, University of Dundee, Scotland (United Kingdom); Nabi, Ghulam [Academic Section of Urology, Division of Cancer Research, School of Medicine, University of Dundee, Scotland (United Kingdom)

    2016-01-01

    Purpose: To determine whether participants taking angiotensin-converting enzyme inhibitors (ACEIs) and treated with radical radiation therapy with neoadjuvant/adjuvant hormone therapy have less incidence, severity, and duration of radiation proctitis. Methods and Materials: A propensity score analysis of 817 patients who underwent radical radiation therapy with neoadjuvant or adjuvant hormone therapy as primary line management in a cohort study during 2009 to 2013 was conducted. Patients were stratified as follows: group 1, hypertensive patients taking ACEIs (as a study group); group 2, nonhypertensive patients not taking ACEIs; and group 3, hypertensive patients not taking ACEIs (both as control groups). The incidence, severity, and duration of proctitis were the main outcome. χ{sup 2} tests, Mann-Whitney U tests, analysis of variance, risk ratio (RR), confidence interval (CI), Kaplan-Meier plots, and log-rank tests were used. Results: The mean age of the participants was 68.91 years, with a follow-up time of 3.38 years. Based on disease and age-matched comparison, there was a statistically significant difference of proctitis grading between the 3 groups: χ{sup 2} (8, n=308) = 72.52, P<.001. The Mann-Whitney U test indicated that grades of proctitis were significantly lower in hypertensive patients taking ACEIs than in nonhypertensive patients not taking ACEIs and hypertensive patients not taking ACEIs (P<.001). The risk ratio (RR) of proctitis in hypertensive patients taking ACEIs was significantly lower than in hypertensive patients not taking ACEIs (RR 0.40, 95% CI 0.30-0.53, P<.001) and in nonhypertensive patients not taking ACEIs (RR 0.58, 95% CI 0.44-0.77, P<.001). Time to event analysis revealed that hypertensive patients taking ACEIs were significantly different from the control groups (P<.0001). Furthermore, hypertensive patients taking ACEIs had significantly faster resolution of proctitis (P<.0001). Conclusion: Patients who were taking ACEIs were

  10. Materias activas permitidas en producción integrada. Frutales de hueso 2016

    OpenAIRE

    Departamento de Desarrollo Rural y Sostenibilidad

    2016-01-01

    Materias activas admitidas en producción integrada para frutales de hueso y las restricciones de uso. Las materias activas de nueva inclusión se indican con asterisco y son admitidas a partir del 1 de enero de 2016.

  11. A double blind controlled trial of prednisolone-21-phosphate suppositories in the treatment of idiopathic proctitis

    Science.gov (United States)

    Lennard-Jones, J. E.; Baron, J. H.; Connell, A. M.; Jones, F. Avery

    1962-01-01

    A double blind trial of prednisolone suppositories in out-patients with idiopathic proctitis is reported. Significant improvement was noted. When prednisolone suppositories were given after the patient had already used suppositories of base alone for three weeks the active treatment was no longer so effective. PMID:13929632

  12. Efficacy and safety of mesalamine suppositories for treatment of ulcerative proctitis in children and adolescents.

    Science.gov (United States)

    Heyman, Melvin B; Kierkus, Jaroslaw; Spénard, Jean; Shbaklo, Hadia; Giguere, Monique

    2010-11-01

    Treatment of ulcerative proctitis has not been well studied in pediatric populations. We conducted an open-label trial to evaluate the clinical efficacy of a mesalamine suppository (500 mg) to treat pediatric patients with mild to moderate ulcerative proctitis. Pediatric patients (5-17 years of age) with ulcerative proctitis were enrolled for baseline evaluations, including a flexible sigmoidoscopic (or colonoscopic) assessment with biopsies performed at study entry. Eligible patients were started on mesalamine suppositories (500 mg) at bedtime. Two follow-up visits were scheduled after 3 and 6 weeks of treatment. The dose could be increased to 500 mg twice daily at the week 3 follow-up visit if deemed appropriate by the investigator based on the Disease Activity Index (DAI) assessment. The primary outcome measure was a DAI derived from a composite score of stool frequency, urgency of defecation, rectal bleeding, and general well-being. Forty-nine patients were included in the intent-to-treat analysis. The mean DAI value decreased from 5.5 at baseline to 1.6 and 1.5 at weeks 3 and 6, respectively (P children with ulcerative proctitis.

  13. Sucralfate paste enema: a new method of topical treatment for haemorrhagic radiation proctitis.

    Science.gov (United States)

    McElvanna, K; Wilson, A; Irwin, T

    2014-04-01

    Rectal sucralfate has been reported to deliver clinical improvement in haemorrhagic radiation proctitis, but patients with active proctitis find the enema suspension difficult to retain thus reducing compliance and effectiveness. We describe a novel method of rectal administration via a low-volume sucralfate paste and report its results in a series of 23 patients. Patients with rectal bleeding occurring more than 6 months after radiotherapy were shown how to prepare and self-administer sucralfate paste enemas (SPEs) twice daily for 6 weeks. The SPE was prepared using two sucralfate 1-g tablets mixed with 4.5 ml of water in an enema applicator producing a low-volume paste. The clinical response was evaluated by comparison of pre- and posttreatment clinical proctitis scores (Radiation Therapy Oncology Group/European Organisation for Research and Treatment of Cancer). Eighteen male (postprostatic radiotherapy) and five female (postcervical radiotherapy) patients with a median age of 67 (32-75) years were included. The median interval between pelvic irradiation and SPE treatment was 24 (7-69) months. Twenty-two patients had full clinical scoring, of whom 16 (73%) demonstrated clinical improvement. Six (27%) had neither clinical improvement nor deterioration. Seven (32%) had resolution of all symptoms. Most patients demonstrated clinical improvement. This initial experience of the sucralfate paste enema may provide the basis for a prospective study of its effectiveness in the treatment of haemorrhagic radiation proctitis. Colorectal Disease © 2013 The Association of Coloproctology of Great Britain and Ireland.

  14. Herpes simplex virus proctitis in homosexual men. Clinical, sigmoidoscopic, and histopathological features.

    Science.gov (United States)

    Goodell, S E; Quinn, T C; Mkrtichian, E; Schuffler, M D; Holmes, K K; Corey, L

    1983-04-14

    Acute herpes simplex virus (HSV) infection was detected in 23 of 102 consecutively examined, sexually active male homosexuals who presented with anorectal pain, discharge, tenesmus, or hematochezia, as compared with 3 of 75 homosexual men without gastrointestinal symptoms (P less than 0.01). Findings that were significantly more frequent in men with HSV proctitis than in men with proctitis due to other infectious causes included fever (48 per cent), difficulty in urinating (48 per cent), sacral paresthesias (26 per cent), inguinal lymphadenopathy (57 per cent), severe anorectal pain (100 per cent), tenesmus (100 per cent), constipation (78 per cent), perianal ulcerations (70 per cent), and the presence of diffuse ulcerative or discrete vesicular or pustular lesions in the distal 5 cm of the rectum (50 per cent). Serologic evidence indicated that 85 per cent of the men with symptomatic HSV proctitis were having their first episode of HSV-2 infection. The diagnosis of HSV proctitis is suggested by the presence of severe anorectal pain, difficulty in urinating, sacral paresthesias or pain, and diffuse ulceration of the distal rectal mucosa.

  15. Vitamin D Deficiency Is Associated With the Severity of Radiation-Induced Proctitis in Cancer Patients

    Energy Technology Data Exchange (ETDEWEB)

    Ghorbanzadeh-Moghaddam, Amir [Medical Student' s Research Center, Isfahan University of Medical Sciences, Isfahan (Iran, Islamic Republic of); Gholamrezaei, Ali, E-mail: Gholamrezaei@med.mui.ac.ir [Medical Student' s Research Center, Isfahan University of Medical Sciences, Isfahan (Iran, Islamic Republic of); Poursina Hakim Research Institution, Isfahan (Iran, Islamic Republic of); Hemati, Simin [Department of Radiotherapy Oncology, Isfahan University of Medical Sciences, Isfahan (Iran, Islamic Republic of)

    2015-07-01

    Purpose: Radiation-induced injury to normal tissues is a common complication of radiation therapy in cancer patients. Considering the role of vitamin D in mucosal barrier hemostasis and inflammatory responses, we investigated whether vitamin D deficiency is associated with the severity of radiation-induced acute proctitis in cancer patients. Methods and Materials: This prospective observational study was conducted in cancer patients referred for pelvic radiation therapy. Serum concentration of 25-hydroxyvitamin D was measured before radiation therapy. Vitamin D deficiency was defined as 25-hydroxyvitamin D concentrations of <35 nmol/L and <40 nmol/L in male and female patients, respectively, based on available normative data. Acute proctitis was assessed after 5 weeks of radiation therapy (total received radiation dose of 50 Gy) and graded from 0 to 4 using Radiation Therapy Oncology Group (RTOG) criteria. Results: Ninety-eight patients (57.1% male) with a mean age of 62.8 ± 9.1 years were studied. Vitamin D deficiency was found in 57 patients (58.1%). Symptoms of acute proctitis occurred in 72 patients (73.4%) after radiation therapy. RTOG grade was significantly higher in patients with vitamin D deficiency than in normal cases (median [interquartile range] of 2 [0.5-3] vs 1 [0-2], P=.037). Vitamin D deficiency was associated with RTOG grade of ≥2, independent of possible confounding factors; odds ratio (95% confidence interval) = 3.07 (1.27-7.50), P=.013. Conclusions: Vitamin D deficiency is associated with increased severity of radiation-induced acute proctitis. Investigating the underlying mechanisms of this association and evaluating the effectiveness of vitamin D therapy in preventing radiation-induced acute proctitis is warranted.

  16. Vitamin D Deficiency Is Associated With the Severity of Radiation-Induced Proctitis in Cancer Patients

    International Nuclear Information System (INIS)

    Ghorbanzadeh-Moghaddam, Amir; Gholamrezaei, Ali; Hemati, Simin

    2015-01-01

    Purpose: Radiation-induced injury to normal tissues is a common complication of radiation therapy in cancer patients. Considering the role of vitamin D in mucosal barrier hemostasis and inflammatory responses, we investigated whether vitamin D deficiency is associated with the severity of radiation-induced acute proctitis in cancer patients. Methods and Materials: This prospective observational study was conducted in cancer patients referred for pelvic radiation therapy. Serum concentration of 25-hydroxyvitamin D was measured before radiation therapy. Vitamin D deficiency was defined as 25-hydroxyvitamin D concentrations of <35 nmol/L and <40 nmol/L in male and female patients, respectively, based on available normative data. Acute proctitis was assessed after 5 weeks of radiation therapy (total received radiation dose of 50 Gy) and graded from 0 to 4 using Radiation Therapy Oncology Group (RTOG) criteria. Results: Ninety-eight patients (57.1% male) with a mean age of 62.8 ± 9.1 years were studied. Vitamin D deficiency was found in 57 patients (58.1%). Symptoms of acute proctitis occurred in 72 patients (73.4%) after radiation therapy. RTOG grade was significantly higher in patients with vitamin D deficiency than in normal cases (median [interquartile range] of 2 [0.5-3] vs 1 [0-2], P=.037). Vitamin D deficiency was associated with RTOG grade of ≥2, independent of possible confounding factors; odds ratio (95% confidence interval) = 3.07 (1.27-7.50), P=.013. Conclusions: Vitamin D deficiency is associated with increased severity of radiation-induced acute proctitis. Investigating the underlying mechanisms of this association and evaluating the effectiveness of vitamin D therapy in preventing radiation-induced acute proctitis is warranted

  17. Deporte Salud y Vida para oyentes de radio Familia 96.9 empleando pausa activa

    OpenAIRE

    Martínez Sarmiento, Marcia Fabiola

    2011-01-01

    Deporte Salud y Vida para oyentes de radio Familia 96.9 empleando pausa activa, un programa de radio que promueve a la práctica de actividad física, que permita contrarrestar las grandes escalas de sedentarismo en nuestra ciudad, gracias al apoyo de este medio de comunicación se implementó la Pausa activa para oyentes de Radio Familia, especialmente amas de casa que fluctúan desde los 20 hasta 75 años. El proyecto tiene también el objetivo de la ejercitación mediante la Pausa Activa dentro...

  18. Chlamydial Proctitis in a Young Man Who Has Sex with Men: Misdiagnosed as Inflammatory Bowel Disease.

    Science.gov (United States)

    Lee, Kyung Jin; Kim, Jaeyeon; Shin, Dong Hwan; Jung, Jun Oh; Koh, Seokyoung; Kim, Ka Young; Lee, Jae Min

    2015-12-01

    We report the case of a 20-year-old man with a 2-month history of anal pain and bloody rectal discharge. He was referred to our clinic of gastroenterology for suspected inflammatory bowel disease (IBD). The colonoscopy showed mucosal nodularities on the rectum and an anal tag. Because the colonoscopic findings were not consistent with the typical manifestations of IBD, we took an additional sexual history and performed studies for infectious proctitis, including serologic tests for Chlamydia trachomatis, Neisseria gonorrhoeae, and Treponema pallidum. He had homosexual experience, and the serologic tests and PCR of a rectal swab were positive for C. trachomatis infection. Finally he was diagnosed as having chlamydial proctitis and was treated with intramuscular ceftriaxone 250 mg in a single dose and doxycycline 100 mg orally twice daily for 7 days. After 2 months, he had no lower abdominal symptoms and his endoscopic findings were improved.

  19. Efficacy and Safety of Mesalamine Suppositories for Treatment of Ulcerative Proctitis in Children and Adolescents

    Science.gov (United States)

    Heyman, Melvin B.; Kierkus, Jaroslaw; Spénard, Jean; Shbaklo, Hadia; Giguere, Monique

    2011-01-01

    Background Treatment of ulcerative proctitis has not been well studied in pediatric populations. We conducted an open-label trial to evaluate the clinical efficacy of a mesalamine suppository (500 mg) to treat pediatric patients with mild to moderate ulcerative proctitis. Methods Pediatric patients (5–17 years of age) with ulcerative proctitis were enrolled for baseline evaluations, including a flexible sigmoidoscopic (or colonoscopic) assessment with biopsies performed at study entry. Eligible patients were started on mesalamine suppositories (500 mg) at bedtime. Two follow-up visits were scheduled after 3 and 6 weeks of treatment. The dose could be increased to 500 mg twice daily at the week 3 follow-up visit if deemed appropriate by the investigator based on the Disease Activity Index (DAI) assessment. The primary outcome measure was a DAI derived from a composite score of stool frequency, urgency of defecation, rectal bleeding, and general well-being. Results Forty-nine patients were included in the intent-to-treat analysis. The mean DAI value decreased from 5.5 at baseline to 1.6 and 1.5 at weeks 3 and 6, respectively (P < 0.0001). Only 4 patients had their dose increased to 500 mg twice daily at week 3. Forty-one patients experienced at least one adverse event, most of which were deemed mild and unrelated to study therapy. The most common treatment-emergent adverse events were gastrointestinal (n = 30, 61.2%). Conclusions This study showed that a daily bedtime dose of a 500 mg mesalamine suppository is safe and efficacious in children with ulcerative proctitis. PMID:20848454

  20. Radiation proctitis after the high dose rate brachytherapy for prostate cancer

    International Nuclear Information System (INIS)

    Kitano, Masashi; Katsumata, Tomoe; Satoh, Takefumi

    2006-01-01

    We reviewed the medical records of 12 patients treated for rectal bleeding after high-dose rate brachytherapy for prostate cancer. All patients developed grade 2 proctitis according to the Common Terminology Criteria for Adverse Events (CTCAC) and no patients needed blood transfusion. The patients were treated with argon plasma coagulation (APC) and/or steroid suppositories. The bleeding stopped or improved in 11 patients. Although re-bleeding was noticed in 7 patients the same treatment was effective in 5 patients. (author)

  1. Sucralfate or placebo following argon plasma coagulation for chronic radiation proctitis: a randomized double blind trial.

    Science.gov (United States)

    Chruscielewska-Kiliszek, M R; Regula, J; Polkowski, M; Rupinski, M; Kraszewska, E; Pachlewski, J; Czaczkowska-Kurek, E; Butruk, E

    2013-01-01

    Chronic radiation proctitis is a long-term complication of radiation therapy for pelvic malignancy. The aim of this study was to compare the efficacy and safety of two treatment regimens, sucralfate or placebo, following argon plasma coagulation (APC) for chronic haemorrhagic radiation proctitis. A single-centre, randomized, placebo-controlled, double-blind study was performed on patients with haemorrhagic chronic radiation proctitis after irradiation for prostate, uterine, cervical, rectal or vaginal cancer. All patients received APC, and were then randomized to oral sucralfate (6 g twice a day) or placebo treatment for 4 weeks. APC was repeated every 8 weeks if necessary after the first session. Patients were graded clinically and endoscopically according to the Chutkan and Gilinski scales before and at 8 and 16 weeks after initial APC treatment (1.5-2 l/min, 25-40 W) and after 52 weeks (clinical only). Of 122 patients, 117 completed the entire protocol, with 57/60 in the sucralfate group and 60/62 in the placebo group. At baseline there were no significant differences between the sucralfate and placebo groups. At 1 year, a significant improvement in the clinical scale in both groups occurred compared with baseline. After 16 weeks, the median overall clinical severity scores fell from 4 to 2 points and the median bleeding score from 2 to 0 in both groups. APC is safe and effective for the management of chronic radiation proctitis. Additional sucralfate treatment did not influence the clinical or endoscopic outcome. © 2012 The Authors. Colorectal Disease © 2012 The Association of Coloproctology of Great Britain and Ireland.

  2. Gastrointestinal symptoms resembling ulcerative proctitis caused by larvae of the drone fly Eristalis tenax.

    Science.gov (United States)

    Desoubeaux, Guillaume; Gaillard, Julien; Borée-Moreau, Diane; Bailly, Éric; Andres, Christian R; Chandenier, Jacques

    2014-04-01

    We report a case of facultative intestinal myiasis due to larvae of the drone fly Eristalis tenax, also named the rat-tailed maggots. The development of larvae in the lower bowel was responsible for non-specific gastrointestinal symptoms that resembled ulcerative proctitis. The diagnosis was established upon the observation of four spontaneously excreted mobile larvae. The definite identification of the E. tenax species was made possible by scanning electron microscopy. The clinical outcome was satisfactory.

  3. Evaluation of quality of polaprezinc suppositories and their clinical effect on radiation proctitis

    International Nuclear Information System (INIS)

    Shikata, Toshiyuki; Nakamura, Takeshi; Hikasa, Shinichi; Hamaguchi, Tsuneo; Doi, Hiroshi; Kamikonya, Norihiko; Kadobayashi, Muneo; Kimura, Takeshi

    2010-01-01

    Polaprezinc (PZ) suppositories have been used for radiation proctitis in our hospital. In this study, we established methods to evaluate the quality of hospital-prepared PZ suppositories and investigated their stability. As PZ is dissociated at an acidic pH but not at a medium pH, the release of PZ from the suppository was carried out using chelatometric titration in weakly acidic buffer solutions (pH 3, pH 4, and pH 5). As the release of PZ from the suppository was fastest in the buffer solution at pH 3, we used this pH for the release test for PZ. Conducting this test in the stability investigation showed that the amount of PZ released from the suppository after 84 days was the same as that immediately after manufacture. We also examined the clinical efficacy of the PZ suppository in 5 patients with radiation proctitis, finding that efficacy was satisfactory in 3 patients. These results indicated that the PZ suppository is a good treatment for radiation proctitis. (author)

  4. Radiation proctitis in the rat. Sequential changes and effects of anti-inflammatory agents

    Energy Technology Data Exchange (ETDEWEB)

    Northway, M.G.; Scobey, M.W.; Geisinger, K.R.

    1988-11-01

    Female Wistar rats were treated with single exposure irradiation to 2 cm of distal colon to cause radiation proctitis. All animals were evaluated by examination, colonoscopy and histologic evaluation for changes post-irradiation. Exposures of 10, 12.5, 15, 17.5, 20, 22.5, 25, 27.5 and 30 Gy caused dose-related clinical and histologic changes peaking at 7 to 15 days post-exposure. Rats treated with 20 Gy were colonoscoped and biopsied daily and showed sequential post-irradiation endoscopic changes ranging from mucosal edema and mild inflammatory changes to erosion and ulcers. Histologically, crypt abscess and mural wall necrosis similar to changes found in the human rectum after radiotherapy were noted. Treatment with nonsteroidal anti-inflammatory agents, (aspirin, indomethacin, piroxicam), misoprostol (a prostaglandin E1 analogue), or sucralfate (an anti-ulcer agent) did not ameliorate nor exacerbate radiation proctitis in rats exposed to 22.5 Gy. We conclude from these data that the female Wistar rat is a good model for studying radiation proctitis because endoscopic, histologic, and clinical changes seen post-exposure closely resemble those found in man.

  5. Radiation proctitis in the rat. Sequential changes and effects of anti-inflammatory agents

    International Nuclear Information System (INIS)

    Northway, M.G.; Scobey, M.W.; Geisinger, K.R.

    1988-01-01

    Female Wistar rats were treated with single exposure irradiation to 2 cm of distal colon to cause radiation proctitis. All animals were evaluated by examination, colonoscopy and histologic evaluation for changes post-irradiation. Exposures of 10, 12.5, 15, 17.5, 20, 22.5, 25, 27.5 and 30 Gy caused dose-related clinical and histologic changes peaking at 7 to 15 days post-exposure. Rats treated with 20 Gy were colonoscoped and biopsied daily and showed sequential post-irradiation endoscopic changes ranging from mucosal edema and mild inflammatory changes to erosion and ulcers. Histologically, crypt abscess and mural wall necrosis similar to changes found in the human rectum after radiotherapy were noted. Treatment with nonsteroidal anti-inflammatory agents, (aspirin, indomethacin, piroxicam), misoprostol (a prostaglandin E1 analogue), or sucralfate (an anti-ulcer agent) did not ameliorate nor exacerbate radiation proctitis in rats exposed to 22.5 Gy. We conclude from these data that the female Wistar rat is a good model for studying radiation proctitis because endoscopic, histologic, and clinical changes seen post-exposure closely resemble those found in man

  6. Consenso mexicano para el diagnóstico y tratamiento de la colitis ulcerosa crónica idiopática

    Directory of Open Access Journals (Sweden)

    J.K. Yamamoto-Furusho

    2018-04-01

    Full Text Available Resumen: Estas guías constituyen una actualización de las guías publicadas en 2007. Desde ese año, los conocimientos acerca de la fisiopatología, así como las opciones terapéuticas, han evolucionado rápidamente, con la aprobación de nuevos agentes, la aparición de nuevos blancos terapéuticos y nuevas estrategias para mejorar los abordajes disponibles previamente.El objetivo de este consenso es promover una actualización y perspectiva mexicana sobre la epidemiología, el diagnóstico así como el tratamiento médico y quirúrgico de la colitis ulcerosa crónica idiopática.Los enunciados fueron finalmente votados y se realizaron las modificaciones finales en la junta de consenso. La evaluación de la evidencia por la clasificación GRADE se realizó al momento del consenso. Abstract: The guidelines presented herein are an updated version of the recommendations published in 2007. Since then, there has been a rapid advance in the knowledge about the pathophysiology of ulcerative colitis and its therapeutic options. New drugs have been approved, novel targeted therapies have emerged, and new strategies have been developed to improve the previously available approaches to the disease.The aim of the present consensus is to promote the current knowledge of and Mexican perspective on the epidemiology, diagnosis, and medical and surgical treatment of chronic idiopathic ulcerative colitis.The final vote on the statements and their ultimate modifications were carried out at the consensus working group meeting. Evidence was evaluated through the GRADE classification. Palabras clave: Colitis ulcerosa crónica idiopática, Diagnóstico, Tratamiento, Epidemiología, Colectomía, Pouchitis, Keywords: Ulcerative colitis, Diagnosis, Treatment, Epidemiology, Colectomy, Pouchitis

  7. Intravesical or intrarectal instillation of Maalox for the treatment of radiation cystitis or proctitis

    International Nuclear Information System (INIS)

    Kawagoe, Koh; Kawana, Takashi

    1989-01-01

    Intravesical or intrarectal instillation of Maalox, a well-known material for protection of mucous epithelia, was performed in 3 cases of radiation cystitis and one case of radiation proctitis, resulting in successful control of hemorrhage. Four cases of uterine cervical cancer with radiotherapy, including 2 cases of primary and 2 cases of postoperative radiotherapy, were managed by Maalox treatment with intervals of one to nine years between radiotherapy and Maalox instillation. One of the three patients with hemorrhagic cystitis, who had received internal iliac arterial embolization at the another hospital, was to be performed the operation of the urinary tract diversion. 50-100 ml of original or 1/2 diluted Maalox was instilled into urinary bladder or rectum with clump of catheter for 30 min. to 1 hr. after sufficient irrigation with 500 ml of 100 times diluted isodine. Blood transfusion for anemia was done in all cases, and antibiotics, or anticoagulant agents were systematically administered in some cases. Macrohematuria or melena ceased within 2 to 8 days after initiation of Maalox therapy in all cases. In one of the three cases of hemorrhagic cystitis, macroscopic hematuria, which reappeared one year later, was also successfully treated by Maalox therapy. In a case of radiation proctitis, though the melena disappeared in 5 days, diarrhea continued and the patient died of the primary disease two months later with the formation of rectovaginal fistula. No ultimate way of treatment of radiation hemorrhagic cystitis or proctitis has been established, though both of them were clinically important and serious side effects of radiotherapy. Therefore, intravesical or intrarectal instillation of Maalox could become one of the leading ways of treatment of intractable hemorrhagic cystitis, because the technique was simple and the effectiveness was valid without any notable side effects. (author)

  8. Efficacy of Polaprezinc for Acute Radiation Proctitis in a Rat Model

    International Nuclear Information System (INIS)

    Doi, Hiroshi; Kamikonya, Norihiko; Takada, Yasuhiro; Fujiwara, Masayuki; Tsuboi, Keita; Inoue, Hiroyuki; Tanooka, Masao; Nakamura, Takeshi; Shikata, Toshiyuki; Tsujimura, Tohru; Hirota, Shozo

    2011-01-01

    Purpose: The purpose of the present study was to standardize the experimental rat model of radiation proctitis and to examine the efficacy of polaprezinc on radiation proctitis. Methods and Materials: A total of 54 female Wistar rats (5 weeks old) were used. The rats were divided into three groups: those treated with polaprezinc (PZ+), those treated with base alone, exclusive of polaprezinc (PZ-), and those treated without any medication (control). All the rats were irradiated to the rectum. Polaprezinc was prepared as an ointment. The ointment was administered rectally each day after irradiation. All rats were killed on the 10th day after irradiation. The mucosal changes were evaluated endoscopically and pathologically. The results were graded from 0 to 4 and compared according to milder or more severe status, as applicable. Results: According to the endoscopic findings, the proportion of mild changes in the PZ+, PZ-, and control group was 71.4%, 25.0%, and 14.3% respectively. On pathologic examination, the proportion of low-grade findings in the PZ+, PZ-, and control group was 80.0%, 58.3%, and 42.9% for mucosal damage, 85.0%, 41.7%, and 42.9% for a mild degree of inflammation, and 50.0%, 33.3%, and 4.8% for a shallow depth of inflammation, respectively. The PZ+ group tended to have milder mucosal damage than the other groups, according to all criteria used. In addition, significant differences were observed between the PZ+ and control groups regarding the endoscopic findings, degree of inflammation, and depth of inflammation. Conclusions: This model was confirmed to be a useful experimental rat model for radiation proctitis. The results of the present study have demonstrated the efficacy of polaprezinc against acute radiation-induced rectal disorders using the rat model.

  9. Políticas activas de empleo para cali-colombia1

    Directory of Open Access Journals (Sweden)

    Carlos Giovanni González Espitia

    2011-01-01

    Full Text Available El artículo discute la implementación de políticas activas de empleo para el mercado laboral en Cali-Colombia. El principal objetivo de una política activa de empleo es la reducción de la tasa de desempleo, la reducción de la participa en la informalidad y el reemplazo de trabajos malos o de baja calidad por trabajos buenos. La acción colectiva de las instituciones regionales públicas, los empresarios regionales y las instituciones académicas es fundamental para alcanzar empleo de alta calidad en la ciudad.

  10. Proctitis as the clinical presentation of lymphogranuloma venereum, a re-emerging disease in developed countries

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    Jorge López-Vicente

    2014-01-01

    Full Text Available Lymphogranuloma venereum (LGV is a sexually transmitted infectious disease caused by serovars L1, L2 and L3 of Chlamydia trachomatis. The initial presentation is usually a painless ulcerated papule on the genitalia or distal proctitis. The progression of the infection can lead to major complications: rectal strictures, intestinal obstruction or perforation. We present five cases of LGV proctitis as the initial presentation of the disease. All patients were male, mean age 44.6 years, with positive serology to human immunodeficiency virus (HIV and promiscuous men who have sex with men (MSM. The initial diagnosis was made by rectosigmoidoscopy indicated for pain and anal discharge. All cases were confirmed by polymerase chain reaction technique in rectal tissue. Endoscopic images obtained showed a great variety of rectal lesions, from mild erythema of the mucosa and ulcers to deep ulcers with elevated borders and purulent exudate. All cases were resolved after treatment with doxycycline for 3 weeks. It emphasizes the importance of suspecting this re-emerging disease in patients with risk factors (HIV and MSM, with the aim of early treatment and to avoid major complications.

  11. Proctitis as the clinical presentation of lymphogranuloma venereum, a re-emerging disease in developed countries.

    Science.gov (United States)

    López-Vicente, Jorge; Rodríguez-Alcalde, Daniel; Hernández-Villalba, Luis; Moreno-Sánchez, Diego; Lumbreras-Cabrera, Mercedes; Barros-Aguado, Carlos; Galán, Juan Carlos

    2014-01-01

    Lymphogranuloma venereum (LGV) is a sexually transmitted infectious disease caused by serovars L1, L2 and L3 of Chlamydia trachomatis. The initial presentation is usually a painless ulcerated papule on the genitalia or distal proctitis. The progression of the infection can lead to major complications: rectal strictures, intestinal obstruction or perforation. We present five cases of LGV proctitis as the initial presentation of the disease. All patients were male, mean age 44.6 years, with positive serology to human immunodeficiency virus (HIV) and promiscuous men who have sex with men (MSM).The initial diagnosis was made by rectosigmoidoscopy indicated for pain and anal discharge. All cases were confirmed by polymerase chain reaction technique in rectal tissue. Endoscopic images obtained showed a great variety of rectal lesions, from mild erythema of the mucosa and ulcers to deep ulcers with elevated borders and purulent exudate. All cases were resolved after treatment with doxycycline for 3 weeks. It emphasizes the importance of suspecting this re-emerging disease in patients with risk factors (HIV and MSM), with the aim of early treatment and to avoid major complications.

  12. The Vita Activa as Compass: Navigating Uncertainty in Teaching with Hannah Arendt

    Science.gov (United States)

    Rogers, Carrie Ann Barnes

    2010-01-01

    This dissertation is an exploration of stories of uncertainty in the lives of elementary teachers and the value that the ideas of Hannah Arendt lend to the discussion around uncertainty. In "The Human Condition" (1958) Hannah Arendt theorizes the life of action, the "vita activa". Arendtian action is inherently uncertain because to be "capable of…

  13. A phase III double-blind randomised study of rectal sucralfate suspension in the prevention of acute radiation proctitis

    International Nuclear Information System (INIS)

    O'Brien, Peter C.; Franklin, C. Ian; Dear, Keith B.G.; Hamilton, Christopher C.; Poulsen, Michael; Joseph, David J.; Spry, Nigel; Denham, James W.

    1997-01-01

    Background and purpose: A limited number of studies have suggested that oral sucralfate reduces the acute and late gastro-intestinal side-effects of pelvic radiotherapy and sucralfate enemas ameliorate symptoms of chronic proctitis. Sucralfate may act via local bFGF at the mucosal level in promoting angiogenesis and reducing epithelial associated microvascular injury. This multi-institutional study was designed to test the hypothesis that sucralfate given as an enema would have a significant protective effect against acute radiation induced rectal injury by direct application to the mucosa. Materials and methods: Eighty-six patients having radiotherapy for localised carcinoma of the prostate were randomised in a double-blind placebo-controlled study to receive either 15 ml of placebo suspension or 3 g of sucralfate in 15 ml suspension, given as a once daily enema during and for 2 weeks following radiotherapy. Assessment was based on the EORTC/RTOG acute toxicity criteria and a patient self-assessment diary. Results: There was no significant difference between placebo and sucralfate for peak incidences of EORTC/RTOG proctitis. For the placebo and sucralfate arms 95 and 88% (difference 7 ± 11%) suffered some degree of proctitis, with 71 and 61% (difference 10 ± 19%) reaching grade 2, respectively. The median period to onset of grade 2 proctitis was 33.5 and 36 days, with the median duration being 9.5 and 15 days, respectively, again these difference being non-significant. Thirty-five and 37% of patients rated the effect of radiotherapy on bowel habit as 'a lot' with a moderate or severe effect on normal daily living in 52 and 49%, respectively. Conclusion: This study suggests that sucralfate given as a once daily enema does not substantially reduce the incidence of symptoms associated with acute radiation proctitis and its routine clinical use cannot be recommended. This cohort of patients will be followed to determine if any difference develops in relation to late

  14. Multiple abdominal nodules in a patient with ulcerative proctitis: a case of peritoneal splenosis

    Directory of Open Access Journals (Sweden)

    Margherita Marocchi

    2013-03-01

    Full Text Available A 40-year old gardener was referred for ulcerative proctitis treated with topical mesalamine with rapid improvement of symptoms. Eighteen years before he had had a splenectomy for traumatic splenic rupture. At the end of 2010, he was admitted to another hospital because of abdominal pain. Computerized tomography (CT scan and magnetic resonance imaging revealed multiple abdominal nodules but a definite diagnosis was not made. While being examined for the proctitis, the patient was admitted to our unit due to worsening of the abdominal pain. After another CT scan, a laparoscopy was performed: several reddish-blue nodules on the peritoneal wall were observed and biopsies were performed. Histological examination was consistent with splenosis. After the procedure, we observed an improvement in the abdominal pain. Splenosis is an acquired condition defined as autotransplantation of viable splenic tissue throughout different sites of the body. It occurs after splenic rupture via trauma or surgery. Splenosis is a benign condition that is usually found incidentally unless symptomatic. Since on radiographic examination it can mimic a neoplasia, extensive workup is usually needed. The diagnostic method of choice is nuclear scintigraphy. Splenosis usually occurs in the abdominal and pelvic cavities but patients have been described with splenosis in other intrathoracic, hepatic and subcutaneous sites. Splenosis is usually asymptomatic and treatment is not necessary. Most patients who have an exploratory laparotomy or laparoscopy for abdominal pain, such as in our patient, experience no more pain after the procedure, regardless of whether the splenic nodules have been completely removed or not. The reason for this spontaneous improvement is not known.

  15. Successful Treatment of Acute Radiation Proctitis with Aloe Vera: A Preliminary Randomized Controlled Clinical Trial.

    Science.gov (United States)

    Sahebnasagh, Adeleh; Ghasemi, Arash; Akbari, Jafar; Alipour, Abbas; Lashkardoost, Hossein; Ala, Shahram; Salehifar, Ebrahim

    2017-11-01

    Acute radiation proctitis (ARP) is a common side-effect that affects up to 50% of patients receiving radiotherapy. The aim of this study was to evaluate the role of a topical preparation of Aloe vera in the treatment of ARP induced by radiotherapy of pelvic area. In this double-blind placebo-controlled trial, 20 consecutive patients with ARP after external-beam radiation therapy (46-72 Gy) of pelvic malignancies were randomized to receive either Aloe vera 3% or placebo ointment, 1 g twice daily for 4 weeks. These patients presented with at least two of the following symptoms: rectal bleeding, abdominal/rectal pain, diarrhea, or fecal urgency. These symptoms were rated by the patients in terms of their severity (grade 0-4) for each of the symptoms mentioned earlier at baseline and then weekly for 4 weeks. A symptom index was calculated by the addition of the scores (16 most symptomatic). Radiation Therapy Oncology Group (RTOG) acute toxicity criteria and psychosocial status of the patients were also recorded weekly. The lifestyle impact of the symptoms was assessed by questionnaire grading from 0 (no effect on daily activity) to 4 (afraid to leave home). There was a significant (p Aloe vera) for diarrhea (median score: 0.67 vs. 0.11), fecal urgency (median score: 0.89 vs. 0.11), clinical presentation total (median score: 4.33 vs. 1.22), RTOG total (median score: 2.89 vs. 0.89), and lifestyle (median score: 1.1 vs. 0.33). Hemorrhage and abdominal/rectal pain did not improve significantly. The odds ratios for advantage of Aloe vera over placebo for "clinical presentation total" and "RTOG total" were 3.97 (1.3-11.9) and 5.9 (1.6-21.6), respectively. A substantial number of patients with radiation proctitis seem to benefit from therapy with Aloe vera 3% ointment.

  16. Infliximab en pacientes con espondilitis anquilosante activa: experiencia en el Hospital Nacional Edgardo Rebagliati Martins

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    Manuel Montero

    2007-06-01

    Full Text Available Infliximab es un medicamento efectivo en el tratamiento de pacientes con espondilitis anquilosante (EA activa. Sin embargo, debido a su alto costo, su uso indiscriminado es prohibitivo. Objetivo: Evaluar si un régimen de inducción con infliximab es efectivo en pacientes con EA activa. Diseño: Sólo expuestos. Lugar: Servicio de Reumatología del Hospital Nacional Edgardo Rebagliati. Participantes: Pacientes con espondilitis anquilosante activa refractaria. Intervenciones: infliximab a las 0, 2 y 6 semanas. Un paciente recibió dosis de 3 mg/kg y los restantes 5 mg/kg de infliximab. Todos los pacientes continuaron recibiendo sulfasalazina. Principales medidas de resultados: Se determinó la proporción de pacientes que alcanzaron mejoría de acuerdo a los criterios ASAS 20, ASAS 40 y BASDAI 50, en la última evaluación (mediana de 55 semanas. Resultados: En la última evaluación, cinco pacientes (71,4% presentaban respuesta ASAS 20 sostenida. Cuatro (57% y tres (43% de los pacientes alcanzaron BASDAI 50 y ASAS 40, respectivamente. Tres pacientes (43% recayeron en un tiempo promedio de 26,6 semanas. No se observó efectos adversos serios. Conclusiones: La infusión de tres dosis de infliximab es efectiva para controlar la actividad de la enfermedad de los pacientes con EA refractaria a AINEs y en algunos pacientes controla la enfermedad por periodos prolongados de tiempo.

  17. A refractory case of radiation proctitis. Effectiveness of argon plasma coagulation therapy and the rectal stenosis after therapy

    International Nuclear Information System (INIS)

    Oyama, Katsunobu; Morita, Akihiko; Terada, Itsuro

    2006-01-01

    A 75-years-old man received external radiation with a cumulative dose of 60 Gy for prostatic cancer. Severe hematochezia occurred approximately 16 months after irradiation. A extensive and circumferential telangiectatic lesion in the lower segment of the rectum was detected, then he was diagnosed as having radiation proctitis. Pharmacotherapy was employed at first, but the bleeding was uncontrollable. Colostomy was performed, but the bleeding could not be controlled. Argon plasma coagulation therapy (APC) was applied, and the bleeding ceased after first session of APC. But the severe rectal stricture appeared three months after APC. APC is effective treatment for refractory radiation proctitis, but the rectal stenosis was occurred three months after APC. (author)

  18. Case report: lymphogranuloma venereum proctitis-from rapid screening to molecular confirmation of a masked sexually transmitted disease.

    Science.gov (United States)

    Markowicz, Mateusz; Grilnberger, Evelyn; Huber, Florian; Leibl, Gabriele; Abrahamian, Heidemarie; Gartner, Manfred; Huber, Monika; Chott, Andreas; Reiter, Michael; Stanek, Gerold

    2013-08-01

    Proctitis caused by Chlamydia trachomatis L2b can manifest with very mild, nonspecific symptoms, and appropriate diagnostic evaluation is crucial. The case report demonstrates that rapid screening test, detection of specific antibodies in serum, and direct pathogen identification by PCR performed on tissue sample or rectal swab allow successful diagnosis of the still emerging sexually transmitted disease among homosexual patients. Copyright © 2013 Elsevier Inc. All rights reserved.

  19. High Prevalence of Neutrophil Cytoplasmic Autoantibodies in Infants with Food Protein-Induced Proctitis/Proctocolitis: Autoimmunity Involvement?

    Directory of Open Access Journals (Sweden)

    Alena Sekerkova

    2015-01-01

    Full Text Available Background. Food protein-induced proctitis/proctocolitis (FPIP is the most common noninfectious colitis in children in the first year of life. Along with the overall clinical symptoms, diarrhoea and rectal bleeding are the main manifestations of the disease. There is no routine noninvasive test that would be specific for this type of colitis. The aim of our study was to find a noninvasive laboratory test or tests that may be helpful in differential diagnosis of food protein-induced proctitis/proctocolitis. Methods. ANA, ANCA, ASCA, a-EMA, a-tTg, specific IgE, total IgE, IgG, IgA, IgM, and concentration of serum calprotectin were measured in a group of 25 patients with colitis and 18 children with other diagnoses. Results. Atypical-pANCA antibodies of IgG isotype were detected in the sera of 24 patients by the method of indirect immunofluorescence, and 5 patients showed also the positivity of IgA isotype. In control samples these autoantibodies were not detected. Other autoantibodies were not demonstrated in either patient or control group. Conclusions. Of the parameters tested in noninfectious colitis, atypical-pANCA on ethanol-fixed granulocytes appears to be a suitable serological marker of food protein-induced proctitis/proctocolitis and suggests a possible involvement of an autoimmune mechanisms in the pathogenesis of this disease.

  20. PROCTITIS ONE WEEK AFTER STEREOTACTIC BODY RADIATION THERAPY FOR PROSTATE CANCER: IMPLICATIONS FOR CLINICAL TRIAL DESIGN

    Directory of Open Access Journals (Sweden)

    Ima Paydar

    2016-07-01

    Full Text Available Background: Proctitis following prostate cancer radiation therapy is a primary determinant of quality of life (QOL. While previous studies have assessed acute rectal morbidity at 1 month after stereotactic body radiotherapy (SBRT, little data exist on the prevalence and severity of rectal morbidity within the first week following treatment. This study reports the acute bowel morbidity one week following prostate SBRT. Materials and methods: Between May 2013 and August 2014, 103 patients with clinically localized prostate cancer were treated with 35 to 36.25 Gy in five fractions using robotic SBRT delivered on a prospective clinical trial. Bowel toxicity was graded using the Common Terminology Criteria for Adverse Events version 4.0 (CTCAEv.4. Bowel QOL was assessed using EPIC-26 questionnaire bowel domain at baseline, one week, one month, and three months. Time-dependent changes in bowel symptoms were statistically compared using the Wilcoxon signed-rank test. Clinically significant change was assessed by the minimally important difference (MID in EPIC score. This was defined as a change of one-half standard deviation (SD from the baseline score. Results: One hundred and three patients with a minimum of three months of follow-up were analyzed. The cumulative incidence of acute grade 2 GI toxicity was 23%. There were no acute ≥ grade 3 bowel toxicities. EPIC bowel summary scores maximally declined at 1 week after SBRT (-13.9, p<0.0001 before returning to baseline at three months after SBRT (+0.03, p=0.94. Prior to treatment, 4.9% of men reported that their bowel bother was a moderate to big problem. This increased to 28.4% (p<0.0001 one week after SBRT and returned to baseline at three months after SBRT (0.0%, p=0.66. Only the bowel summary and bowel bother score declines at 1 week met the MID threshold for clinically significant change. Conclusion: The rate and severity of acute proctitis following prostate SBRT peaked at one week after

  1. Los Sistemas de Suspensión Activa y Semiactiva: Una Revisión

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    Jorge Hurel Ezeta

    2013-04-01

    Full Text Available Resumen: El propósito de este artículo es efectuar una revisión del estado del conocimiento en el modelado y control de los sistemas de suspensión activa y semiactiva. Se analizan las principales características de los diferentes tipos de sistemas de suspensión: pasiva, activa y semiactiva. Respecto al modelado y simulación de los sistemas de suspensión, se examinan los distintos enfoques, herramientas y aplicaciones en el contexto de la dinámica vehicular. Además, para el modelo de un cuarto de vehículo, ampliamente utilizado en la literatura, se ofrece su desarrollo mediante ecuaciones diferenciales, función de transferencia, y ecuaciones de estado, incluyendo soluciones y simulaciones en Simulink y SimMechanics. En cuanto al control, se revisan las principales estrategias para la suspensión de vehículos y se apuntan aplicaciones en otros campos de la ingeniería. Abstract: This paper reviews the state of the art in modeling and control of active and semi-active suspension systems. Distinctive characteristics are established for the major types of suspension systems: passive, active, and semi-active. Regarding modeling and simulation, different approaches, tools and applications are discussed in the context of vehicle dynamics. Besides, the quarter car model, which is widely used in research, is developed with differential equations, transfer functions, and state-space equations, as well as solutions for simulation in Simulink and SimMechanics. As for control of active and semi-active systems, the major strategies for vehicle suspension are reviewed. Furthermore, the paper outlines suspension control in other engineering applications. Palabras clave: Simulación, Suspensión activa, Modelos, Suspensión pasiva, Robótica, Keywords: Active suspension, Passive suspension, Models, Control

  2. As políticas activas e passivas do mercado de trabalho

    OpenAIRE

    Novo, Álvaro; Centeno, Mário

    2008-01-01

    A generalidade dos países utiliza políticas destinadas a minorar os custos sociais e individuais do desemprego. Os economistas classificam estas políticas do mercado de trabalho em dois grupos: (i) políticas activas e (ii) políticas passivas. As primeiras têm como objectivo dotar os desempregados com as qualificações necessárias para minimizar a duração do desemprego, enquanto as segundas visam garantir uma fonte de rendimento durante o período de desemprego, sendo particularmente úteis para ...

  3. A phase III randomized, placebo-controlled, double-blind study of misoprostol rectal suppositories to prevent acute radiation proctitis in patients with prostate cancer

    International Nuclear Information System (INIS)

    Hille, Andrea; Schmidberger, Heinz; Hermann, Robert M.; Christiansen, Hans; Saile, Bernhard; Pradier, Olivier; Hess, Clemens F.

    2005-01-01

    Purpose: Acute radiation proctitis is the most relevant complication of pelvic radiation and is still mainly treated supportively. Considering the negative impact of acute proctitis symptoms on patients' daily activities and the potential relationship between the severity of acute radiation injury and late damage, misoprostol was tested in the prevention of acute radiation-induced proctitis. Methods and Materials: A total of 100 patients who underwent radiotherapy for prostate cancer were entered into this phase III randomized, placebo-controlled, double-blind study with misoprostol or placebo suppositories. Radiation-induced toxicity was evaluated weekly during radiotherapy using the Common Toxicity Criteria. Results: Between the placebo and the misoprostol groups, no significant differences in proctitis symptoms occurred: 76% of patients in each group had Grade 1 toxicity, and 26% in the placebo group and 36% in the misoprostol group had Grade 2 toxicity. No differences were found in onset or symptom duration. Comparing the peak incidence of patients' toxicity symptoms, significantly more patients experienced rectal bleeding in the misoprostol group (p = 0.03). Conclusion: Misoprostol given as a once-daily suppository did not decrease the incidence and severity of radiation-induced acute proctitis and may increase the incidence of acute bleeding

  4. GESTIÓN ACTIVA DE PORTAFOLIOS MEDIANTE LA APLICACIÓN DEL MODELO DE TREYNOR - BLACK

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    Alejandro Vargas Sánchez

    2012-07-01

    Full Text Available En el presente documento se expone la teoría de gestión activa de portafolios a través de la aplicación del modelo de Treynor Black. El objetivo principal es mostrar el impacto positivo que una gestión activa de portafolios puede tener en términos de rendimiento y riesgo, permitiendo de esta manera desplazar positivamente la función de utilidad de un inversionista adverso al riesgo; estos beneficios se pueden alcanzar a partir de la incorporación de títulos valores con rendimientos anormales cuyos precios de mercado son diferentes a sus valores de equilibrio. Los resultados alcanzados permiten corroborar esta situación, aunque también se pone de manifiesto que cuando los rendimientos anormales son muy elevados, puede dar como consecuencia que el portafolio de activos riesgosos se concentre excesivamente en aquellos títulos con rendimientos anormales generando mayor exposición a los riesgos no sistemáticos.

  5. Efficacy of Synbiotics to Reduce Acute Radiation Proctitis Symptoms and Improve Quality of Life: A Randomized, Double-Blind, Placebo-Controlled Pilot Trial

    International Nuclear Information System (INIS)

    Nascimento, Mariana; Aguilar-Nascimento, José Eduardo; Caporossi, Cervantes; Castro-Barcellos, Heloisa Michelon; Motta, Rodrigo Teixeira

    2014-01-01

    Purpose: To evaluate whether the daily intake of synbiotics interferes in radiation-induced acute proctitis symptoms and in quality of life in patients with prostate cancer. Methods and Materials: Twenty patients who underwent 3-dimensional conformal radiation therapy for prostate cancer were randomized to intake either a synbiotic powder containing Lactobacillus reuteri 10 8  colony-forming units and 4.3 g of soluble fiber (Nestlé) or placebo. The questionnaire EORTC QLQ-PRT23 was applied before the beginning of radiation therapy and in every week for the first 4 weeks of treatment. The sum of both the complete (proctitis symptoms plus quality of life) and partial (proctitis symptoms) scores of the EORTC QLQ-PRT23 (European Organization for Research and Treatment of Cancer Quality of Life Module for Proctitis–23 items) questionnaire were the main endpoints. Results: This pilot study showed that the complete questionnaire score (median [range]) was higher in the second (23 [21-30] vs 26.5 [22-34], P<.05) and third (23 [21-32] vs 27.5 [24-33], P<.01) weeks in the placebo group. Proctitis symptoms were highest scored in the placebo group in both the second (19.5 [16-25]) and third (19 [17-24]) weeks than in the synbiotic group (week 2: 16.5 [15-20], P<.05; week 3: 17 [15-23], P<.01). In both scores the placebo group had a significantly higher result (P<.01) than the synbiotic group (repeated-measures analysis of variance). Conclusions: Synbiotics reduce proctitis symptoms and improve quality of life in radiation-induced acute proctitis during radiation therapy for prostate cancer

  6. WE-D-BRE-05: Prediction of Late Radiation-Induced Proctitis in Prostate Cancer Patients Using Chromosome Aberration and Cell Proliferation Rate

    Energy Technology Data Exchange (ETDEWEB)

    Oh, J; Deasy, J [Memorial Sloan Kettering Cancer Center, New York, NY (United States)

    2014-06-15

    Purpose: Chromosome damage and cell proliferation rate have been investigated as potential biomarkers for the early prediction of late radiationinduced toxicity. Incorporating these endpoints, we explored the predictive power for late radiation proctitis using a machine learning method. Methods: Recently, Beaton et al. showed that chromosome aberration and cell proliferation rate could be used as biomarkers to predict late radiation proctitis (Beaton et al. (2013) Int J Rad Onc Biol Phys, 85:1346–1352). For the identification of radiosensitive biomarkers, blood samples were collected from 10 patients with grade 3 late proctitis along with 20 control patients with grade 0 proctitis. After irradiation at 6 Gy, statistically significant difference was observed between the two groups, using the number of dicentrics and excess fragments, and the number of cells in metaphase 2 (M2). However, Beaton et al. did not show the usefulness of combining these endpoints. We reanalyzed the dataset to investigate whether incorporating these endpoints can increase the predictive power of radiation proctitis, using a support vector machine (SVM). Results: Using the SVM method with the number of fragments and M2 endpoints, perfect classification was achieved. In addition, to avoid biased estimate of the classification method, leave-one-out cross-validation (LOO-CV) was performed. The best performance was achieved when all three endpoints were used with 87% accuracy, 90% sensitivity, 85% specificity, and 0.85 AUC (the area under the receiver operating characteristic (ROC) curve). The most significant endpoint was the number of fragments that obtained 83% accuracy, 70% sensitivity, 90% specificity, and 0.82 AUC. Conclusion: We demonstrated that chromosome damage and cell proliferation rate could be significant biomarkers to predict late radiation proctitis. When these endpoints were used together in conjunction with a machine learning method, the better performance was obtained

  7. Efficacy of Synbiotics to Reduce Acute Radiation Proctitis Symptoms and Improve Quality of Life: A Randomized, Double-Blind, Placebo-Controlled Pilot Trial

    Energy Technology Data Exchange (ETDEWEB)

    Nascimento, Mariana, E-mail: mari1980hemato@yahoo.com.br [Department of Medicine, University Center of Varzea Grande (UNIVAG), Varzea Grande, Mato Grosso (Brazil); Aguilar-Nascimento, José Eduardo [Department of Medicine, University Center of Varzea Grande (UNIVAG), Varzea Grande, Mato Grosso (Brazil); Caporossi, Cervantes; Castro-Barcellos, Heloisa Michelon; Motta, Rodrigo Teixeira [Department of Medicine, Federal University of Mato Grosso (UFMT), Cuiabá, Mato Grosso (Brazil)

    2014-10-01

    Purpose: To evaluate whether the daily intake of synbiotics interferes in radiation-induced acute proctitis symptoms and in quality of life in patients with prostate cancer. Methods and Materials: Twenty patients who underwent 3-dimensional conformal radiation therapy for prostate cancer were randomized to intake either a synbiotic powder containing Lactobacillus reuteri 10{sup 8} colony-forming units and 4.3 g of soluble fiber (Nestlé) or placebo. The questionnaire EORTC QLQ-PRT23 was applied before the beginning of radiation therapy and in every week for the first 4 weeks of treatment. The sum of both the complete (proctitis symptoms plus quality of life) and partial (proctitis symptoms) scores of the EORTC QLQ-PRT23 (European Organization for Research and Treatment of Cancer Quality of Life Module for Proctitis–23 items) questionnaire were the main endpoints. Results: This pilot study showed that the complete questionnaire score (median [range]) was higher in the second (23 [21-30] vs 26.5 [22-34], P<.05) and third (23 [21-32] vs 27.5 [24-33], P<.01) weeks in the placebo group. Proctitis symptoms were highest scored in the placebo group in both the second (19.5 [16-25]) and third (19 [17-24]) weeks than in the synbiotic group (week 2: 16.5 [15-20], P<.05; week 3: 17 [15-23], P<.01). In both scores the placebo group had a significantly higher result (P<.01) than the synbiotic group (repeated-measures analysis of variance). Conclusions: Synbiotics reduce proctitis symptoms and improve quality of life in radiation-induced acute proctitis during radiation therapy for prostate cancer.

  8. [Reversion of overweight and obesity in Vilafranca del Penedès child population: ACTIVA'T Program (2012)].

    Science.gov (United States)

    Bibiloni, Maria Del Mar; Fernández-Blanco, Jordi; Pujol-Plana, Noemí; Surià Sonet, Sònia; Pujol-Puyané, Maria Cèlia; Mercadé Fuentes, Sílvia; Ojer Fernández de Soto, Laura; Tur, Josep A

    2017-11-20

    To assess a 6-month nutritional and physical activity intervention program on the nutritional status of overweight or obese and not very active 8-14 years old children by means of a controlled pre-post design (ACTIVA'T program). Pre-post study in 8-14 years old overweight or obese and low active children from Vilafranca del Penedès (Barcelona, Spain) randomized in control group (n = 51, 47.1% girls, nutritional intervention and ≤3h/wk physical activity) and ACTIVA'T group (n = 45, 37.8% girls, nutritional and physical activity ≥5h/wk intervention). Body mass index, waist/height index, and diet quality by means of KIDMED test at the beginning and at the end of the program were assessed. During the intervention, each participant was accompanied by a relative (father or mother) who performed the same activities as the children. Dietary recommendations have positively changed the habits of both ACTIVA'T and control group. The reversion in the prevalence of overweight and obesity was 93.8% and 58.6%, respectively, in the ACTIVA'T group, compared to 25.0% and 35.8% in the control group. Abdominal obesity was decreased from 42.2% to 17.8% in the ACTIVA'T group and from 47.1% to 27.5% in the control group. The program ACTIVA'T (nutritional education and physical activity promotion) improves the quality of diet and reverses the prevalence of overweight and obesity in the underactive child population. Copyright © 2017 SESPAS. Publicado por Elsevier España, S.L.U. All rights reserved.

  9. Colostomy is a simple and effective procedure for severe chronic radiation proctitis.

    Science.gov (United States)

    Yuan, Zi-Xu; Ma, Teng-Hui; Wang, Huai-Ming; Zhong, Qing-Hua; Yu, Xi-Hu; Qin, Qi-Yuan; Wang, Jian-Ping; Wang, Lei

    2016-06-28

    To assess the efficacy and safety of diverting colostomy in treating severe hemorrhagic chronic radiation proctitis (CRP). Patients with severe hemorrhagic CRP who were admitted from 2008 to 2014 were enrolled into this study. All CRP patients were diagnosed by a combination of pelvic radiation history, clinical rectal bleeding, and endoscopic findings. Inclusion criteria were CRP patients with refractory bleeding with moderate to severe anemia with a hemoglobin level colostomy, while the control group included patients who received conservative treatment. The remission of bleeding was defined as complete cessation or only occasional bleeding that needed no further treatment. The primary outcome was bleeding remission at 6 mo after treatment. Quality of life before treatment and at follow-up was evaluated according to EORTC QLQ C30. Severe CRP complications were recorded during follow-up. Forty-seven consecutive patients were enrolled, including 22 in the colostomy group and 27 in the conservative treatment group. When compared to conservative treatment, colostomy obtained a higher rate of bleeding remission (94% vs 12%), especially in control of transfusion-dependent bleeding (100% vs 0%), and offered a better control of refractory perianal pain (100% vs 0%), and a lower score of bleeding (P colostomy achieved better remission of both moderate bleeding (100% vs 21.5%, P = 0.002) and severe bleeding (100% vs 0%, P colostomy, which included global health, function, and symptoms, but it was not improved in the control group. Pathological evaluation after colostomy found diffused chronic inflammation cells, and massive fibrosis collagen depositions under the rectal wall, which revealed potential fibrosis formation. Diverting colostomy is a simple, effective and safe procedure for severe hemorrhagic CRP. Colostomy can improve quality of life and reduce serious complications secondary to radiotherapy.

  10. Procesos de formación para una ciudadanía activa

    Directory of Open Access Journals (Sweden)

    Amelia Molina García

    2014-12-01

    Full Text Available El libro reseñado aborda cuatro ejes, presentados en igual número de capítulos: el primero, historia del pensamiento político del mundo occidental; el segundo, se aboca a recuperar los posicionamientos teóricos en torno a las dificultades para el ejercicio de una ciudadanía basada en la justicia y la democracia; el tercero, revisa las maneras como se ha entendido la formación ciudadana en México, en especial, desde los proyectos educativos. Finalmente, en el capítulo cuarto la autora examina las competencias para la capacidad de agencia, las cuales se requieren para el ejercicio de una ciudadanía activa, y son rasgos para considerar al ciudadano como sujeto práxico, en el que se consideran dos ejes fundamentales: la política y la ética.

  11. Intrarectal amifostine suspension may protect against acute proctitis during radiation therapy for prostate cancer: A pilot study

    International Nuclear Information System (INIS)

    Singh, Anurag K.; Menard, Cynthia; Guion, Peter; Simone, Nicole L.; Smith, Sharon; Crouse, Nancy Sears; Godette, Denise J.; Cooley-Zgela, Theresa; Sciuto, Linda C.; Coleman, Jonathan; Pinto, Peter; Albert, Paul S.; Camphausen, Kevin; Coleman, C. Norman

    2006-01-01

    Purpose: Our goal was to test the ability of intrarectal amifostine to limit symptoms of radiation proctitis. Methods and Materials: The first 18 patients received 1 g of intrarectal amifostine suspension placed 30-45 min before each radiation treatment. The following 12 patients received 2 g of amifostine. Total dose prescribed ranged from 66 to 76 Gy. All patients were treated with three-dimensional conformal radiation therapy. The suspension remained intrarectal during treatment and was expelled after treatment. For gastrointestinal symptoms, during treatment and follow-up, all patients had a Radiation Therapy Oncology Group (RTOG) grade recorded. Results: Median follow-up was 18 months (range, 6-24 months). With 2 g vs. 1 g amifostine, there was a nearly significant decrease in RTOG Grade 2 acute rectal toxicity. Seven weeks after the start of radiation therapy, the incidence of Grade 2 toxicity was 33% in the 1-g group (6/18) compared with 0% (0/12) in the 2-g group (p = 0.06). No Grade 3 toxicity or greater occurred in this study. Conclusion: This trial suggests greater rectal radioprotection from acute effects with 2 g vs. 1 g amifostine suspension. Further studies should be conducted in populations at higher risk for developing symptomatic acute and late proctitis

  12. Abscess of the iliopsoas muscle associated external fistula of the rectum caused by radiation proctitis. A case report

    Energy Technology Data Exchange (ETDEWEB)

    Hasegawa, Shigeru; Imazu, Hiroki; Matubara, Toshiki; Sakurai, Yoichi; Ochiai, Masahiro; Funabiki, Takahiko [Fujita Health Univ., Toyoake, Aichi (Japan). School of Medicine

    1999-12-01

    This paper deals with a case of abscess of the iliopsoas muscle, an intractable external fistula of the rectum caused by radiation proctitis in a 68-year-old man. There were previous histories of undergoing an A-C bypass operation for coronary stricture 10 years before; and undergoing aportial resection of the bladder with radiation therapy for urinary bladder cancer, followed by colostomy for hemorrhage and stricture of the rectum for radiation proctitis 2 years before admission. In April, 1997 when he had been treated at outpatient clinic, exhumation of pusfrom the sacurred that was diagnosed external fistula of the rectum on a fistulography and he was continuously treated on an ambulant basis. On November 17, 1997, the patient had a temperature 38.7deg C, the white blood cell count increased to 35 x 10{sup 4} /ml, inflammation reaction increased, and unconsciousness appeared. An emergency CT revealed retention of fluid in the retroperitoneum covering from the fistulation through the iliopsoas muscle to pelvis. An abscess of the iliopsoas muscle was diagnosed. It was determined that any operations under general anesthesia were impossible due to poor general condition, and an emergency incision drainage was performed under local anesthesia. Thereafter, the patient developed MRSA septicemia which demanded redrainage and strict general management, but he was successfully freed from the management. Although the intractable fistula in persistently present, he was discharged after a resection of sequestrum and is followed on an ambulant basis. (author)

  13. Radiation proctitis. Clinical and pathological manifestations, therapy and prophylaxis of acute and late injurious effects of radiation on the rectal mucosa

    International Nuclear Information System (INIS)

    Zimmermann, F.B.; Feldmann, H.J.

    1998-01-01

    Background: Often the rectum is the dose-limiting organ in curative radiation therapy of pelvic malignancies. It reacts with serous, mucoid, or more rarely bloody diarrhea. Methods: A research for reports on prophylactic and supportive therapies of radiation-induced proctitis was performed (Medline, Cancerlit, and others). Results: No proven effective prophylactic local or systemic therapies of radiation proctitis exist. Also, no reasonable causal medication is known. In the treatment of late radiation sequelae no clinically tested certain effective therapy exists, too. Antiinflammatory, steroidal or non-steroidal therapeutics as well as sucralfate can be used as topical measures. They will be successful in some patients. Side effects are rare and the therapy is cost-effective. Treatment failures can be treated by hyperbaric oxygen. This will achieve good clinical results in about 50% of the cases. Single or few mucosal telangiectasias with rectal bleeding can be treated sufficiently by endoscopic cautherization. Conclusion: Besides clinical studies acute proctitis should be treated just symptomatically. Radical surgery should be performed only when all conventional treatments have been uneffective, although no certain effective therapies of radiation-induced late proctitis exist. (orig.) [de

  14. Comparison of Sucralfate and Hydrocortisone Enemas in Treatment of Active Ulcerative Proctitis; A Double-Blind Randomized ClinicalL Trial

    Directory of Open Access Journals (Sweden)

    Mohammad Reza Javadi

    2003-08-01

    Full Text Available Sucralfate enema has been proposed and investigated in treatment of ulcerative proctitis, but its efficacy is still a matter of debate. Hydrocortisone enema is still an established drug in treatment of ulcerative proctitis. This study was designed to compare the effect of sucralfate enema with hydrocortisone enema. Patients with active sigmoidoscopic and histologic features of ulcerative proctitis were included. All patients had clinical manifestations of proctitis for at least four weeks prior to the study and had negative parasitic stool culture. The total of 25 patients entered the study. They were randomly divided in two groups; group I (n =14 and group II (n = 11 who received sucralfate and hydrocortisone enemas respectively for 4 weeks. Both groups had a significant improvement in clinical features, histologic activity and sigmoidoscopic evaluation in comparison with the baseline. Furthermore there was no significant differences between the two groups concerning mean changes of clinical, sigmoidoscopic, and histologic grading, after treatment. Considering the low cost and minimal adverse effects of sucralfate, and almost equal efficacy in comparison with hydrocortisone enema, its usage can be recommended.

  15. Use of mesalazine slow release suppositories 1 g three times per week to maintain remission of ulcerative proctitis: a randomised double blind placebo controlled multicentre study

    Science.gov (United States)

    Marteau, P; Crand, J; Foucault, M; Rambaud, J

    1998-01-01

    Background—Daily administration of rectal formulations of mesalazine is effective in preventing relapse of ulcerative proctitis. Maintenance of remission with lower doses would be an advantage. 
Aim—The efficacy of mesalazine suppositories (Pentasa) 1 g three times a week v placebo to maintain remission in patients with cryptogenetic proctitis was studied. 
Methods—Ninety five patients with cryptogenetic proctitis were randomised within two weeks of remission to receive for one year or until relapse three suppositories per week of either Pentasa (n=48) or placebo (n=47). In the case of a relapse, the patients received one suppository/day. 
Results—It was found that 25 of 48 subjects v 18 of 47 remained in remission in the mesalazine and placebo groups respectively. The relapse rate was lower in the mesalazine group for the following time intervals: 0-90 days (19% v 38%, p=0.035), 0-180 days (29% v 54%, p=0.017), 0-270 days (38% v 60%, p=0.031), and 0-365 days (48% v 62%, p=0.18). Treatment of relapse with one suppository/day induced remission in 11 of 18 and 2 of 26 patients in the mesalazine and placebo groups respectively (p=0.001). Overall, 61% v 28% patients remained in the protocol and were in remission at one year (p=0.001). Tolerance was good. 
Conclusion—Mesalazine suppositories 1 g three times a week are effective for preventing relapses of cryptogenetic proctitis. Increasing the dose to 1 g/day is effective in a high proportion of subjects who relapsed. 

 Keywords: inflammatory bowel disease; mesalazine; 5-aminosalicylic acid; topical treatments; proctitis PMID:9536943

  16. Role of mastocytes in the development of in vivo radiation proctitis and in vitro endothelial response to irradiation

    International Nuclear Information System (INIS)

    Blirando, Karl

    2011-01-01

    Radiation therapy is used alone or in combination with chemotherapy in more than 50 % of cancer treatments. Despite recent advances in treatment delivery such as dose-sculpting techniques, irradiation of healthy tissues surrounding the tumor and the associated side effects limit the radiation amount used. Those side effects when concerning the gastro-intestinal tract have profound repercussions on patient's quality of life and may even engage their vital prognosis. The comprehension of the mechanisms implicated in the development of these lesions is thus a major stake in the identification of therapeutic targets allowing their prevention and treatment. During my PhD, we studied the role of mast cells in the development of radiation proctitis in vivo and in the endothelial response to irradiation in vitro. Our results suggest that mast cells have a deleterious role in the development of human and murine radiation proctitis, in particular by the influence of some of its mediators such as histamine and proteases on the phenotype of the smooth muscle cells of the muscularis propria. Targeting mast cells mediators may represent new therapeutic tools to prevent and / or limit digestive radiation damage. Other shares our work shows that mast cells mediators such as histamine can exacerbate the endothelial inflammatory response to irradiation by mechanisms involving the activation of the p38MAP-Kinase pathway and the transcription factor NF-κB. The study of intracellular signaling pathways activated during radiation damage development may offer new therapeutic possibilities in the management of healthy tissues radiation damage. (author)

  17. Comunicación y Paz Activa: un diálogo posible

    Directory of Open Access Journals (Sweden)

    Maximiliano Martín Vicente

    Full Text Available ResumenEl presente texto tiene como finalidad demostrar que es posible relacionar la Comunicación con la Cultura de la Paz, ambas entendidas como herramientas dinamizadoras y transformadoras de realidades sociales. Para eso se realiza, en un primer momento, una revisión bibliográfica de los estudios de la Comunicación y la Paz identificando sus convergencias y divergencias, tanto metodológicas como de contenido. En segundo lugar, siguiendo el método de procedimiento de la pragmática del Periodismo (Motta, 2007, que permite entender los hechos con profundidad identificando los intereses ocultos, se hace una análisis de la primavera árabe tal como mostrada por Le Monde Diplomatique. Finalmente, en tercer lugar, teniendo como referencia el caso árabe, presentamos lo que entendemos por Comunicación y Paz Activa y cómo deben proceder para actuar conjuntamente para establecer acciones más críticas y transformadoras que lleven a una sociedad más justa e armónica.

  18. La memoria activa del saber pedagógico en la contemporaneidad

    Directory of Open Access Journals (Sweden)

    Vladimir ZAPATA VILLEGAS

    2013-11-01

    Full Text Available El artículo presenta el reencuentro crítico de tres proyectos paradigmáticos de la memoria activa del saber pedagógico: Comenio, proyecto de Didáctica; Herbart, proyecto de Pedagogía y Dewey, proyecto de Educación, con algunas pro- blemáticas teóricas de la actualidad acerca de la educación y la enseñanza. Los resultados de dicha interlocución se vinculan hoy a una memoria viva. Se utilizaron como herramientas metodológicas el cruce de diversos enfoques y técnicas tales como: la formación de los conceptos en la arqueología de los saberes, según los aportes de Foucault; la historia de conceptos practicada por Koselleck; y la relación del concepto con el presente, desde la epistemología. Los tres pedagogos fueron abordados desde dos perspectivas: 1 la relación de sus obras maestras con el momento histórico de su producción, y 2 la inscripción en un orden temporal diferente al de su producción.

  19. Gestión activa frente a gestión indexada de los fondos de inversión

    OpenAIRE

    Gete Arauzo, Leticia

    2017-01-01

    Este trabajo analiza las variables que influyen en los fondos de inversión de gestión activa y de gestión pasiva en el período comprendido entre 2009 y 2016 con el objetivo de comparar ambas gestiones. Departamento de Economía Financiera y Contabilidad Máster en Investigación en Contabilidad y Gestión Financiera

  20. Daily Sodium Butyrate Enema for the Prevention of Radiation Proctitis in Prostate Cancer Patients Undergoing Radical Radiation Therapy: Results of a Multicenter Randomized Placebo-Controlled Dose-Finding Phase 2 Study

    Energy Technology Data Exchange (ETDEWEB)

    Maggio, Angelo, E-mail: maggio.angelo@gmail.com [Medical Physics, San Raffaele Scientific Institute, Milan (Italy); Magli, Alessandro [Department of Radiotherapy, Ospedale S. Maria della Misericordia, Udine (Italy); Rancati, Tiziana [Prostate Cancer Programme, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan (Italy); Fiorino, Claudio [Medical Physics, San Raffaele Scientific Institute, Milan (Italy); Valvo, Francesca [Division of Radiation Oncology 1, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan (Italy); Fellin, Giovanni [Department of Radiotherapy, Ospedale Santa Chiara, Trento (Italy); Ricardi, Umberto [University of Turin, Department of Oncology, Torino (Italy); Munoz, Fernando [Radiotherapy Unit, AO Città della Salute e della Scienza di Torino, Torino (Italy); Cosentino, Dorian; Cazzaniga, Luigi Franco [Ospedale S. Anna, Como (Italy); Valdagni, Riccardo [Prostate Cancer Programme, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan (Italy); Division of Radiation Oncology 1, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan (Italy); Vavassori, Vittorio [Department of Radiotherapy, Ospedale di Circolo, Varese (Italy)

    2014-07-01

    Purpose: To evaluate the efficacy of sodium butyrate enemas (NABUREN) in prostate cancer radiation therapy (RT) in reducing the incidence, severity, and duration of acute RT-induced proctitis. Methods and Materials: 166 patients, randomly allocated to 1 of 4 groups (rectal sodium butyrate 1 g, 2 g, or 4 g daily or placebo), were treated with NABUREN during and 2 weeks after RT. The grade of proctitis was registered in a daily diary. The correlation between NABUREN and proctitis was investigated through χ{sup 2} statistics. The toxicity endpoints considered were as follows: total number of days with grade ≥1 proctitis (≥G1); total number of days with grade ≥2 proctitis (≥G2); ≥G1 and ≥G2 proctitis lasting at least 3 and 5 consecutive days starting from week 4 (≥G1+3d, ≥G2+3d); damaging effects of RT on rectal mucosa as measured by endoscopy. The relationship between endpoints and pretreatment morbidities, hormonal therapy, presence of diabetes or hypertension, abdominal surgery, or hemorrhoids was investigated by univariate analysis. Results: The patients were randomly allocated to the 4 arms. No difference in the distribution of comorbidities among the arms was observed (P>.09). The mean ≥G1 and ≥G2 proctitis were 7.8 and 4.9 for placebo and 8.9 and 4.7 for the NABUREN group, respectively. No favorable trend in reduction of incidence, severity, and duration of ≥G1 and ≥G2 proctitis was observed with NABUREN use. In univariate analysis, ≥G1+3d toxicity was found to be related to hemorrhoids (P=.008), and a slight correlation was found between ≥G2 proctitis and hormonal therapy (P=.06). The RT effects on rectal mucosa as based on endoscopic assessment were mainly related to diabetes (P<.01). Endoscopy data at 6 week showed no significant difference between the placebo and butyrate arms. The other investigated endpoints were not correlated with any of the clinical risk factors analyzed. Conclusion: There was no evidence of efficacy

  1. Daily Sodium Butyrate Enema for the Prevention of Radiation Proctitis in Prostate Cancer Patients Undergoing Radical Radiation Therapy: Results of a Multicenter Randomized Placebo-Controlled Dose-Finding Phase 2 Study

    International Nuclear Information System (INIS)

    Maggio, Angelo; Magli, Alessandro; Rancati, Tiziana; Fiorino, Claudio; Valvo, Francesca; Fellin, Giovanni; Ricardi, Umberto; Munoz, Fernando; Cosentino, Dorian; Cazzaniga, Luigi Franco; Valdagni, Riccardo; Vavassori, Vittorio

    2014-01-01

    Purpose: To evaluate the efficacy of sodium butyrate enemas (NABUREN) in prostate cancer radiation therapy (RT) in reducing the incidence, severity, and duration of acute RT-induced proctitis. Methods and Materials: 166 patients, randomly allocated to 1 of 4 groups (rectal sodium butyrate 1 g, 2 g, or 4 g daily or placebo), were treated with NABUREN during and 2 weeks after RT. The grade of proctitis was registered in a daily diary. The correlation between NABUREN and proctitis was investigated through χ 2 statistics. The toxicity endpoints considered were as follows: total number of days with grade ≥1 proctitis (≥G1); total number of days with grade ≥2 proctitis (≥G2); ≥G1 and ≥G2 proctitis lasting at least 3 and 5 consecutive days starting from week 4 (≥G1+3d, ≥G2+3d); damaging effects of RT on rectal mucosa as measured by endoscopy. The relationship between endpoints and pretreatment morbidities, hormonal therapy, presence of diabetes or hypertension, abdominal surgery, or hemorrhoids was investigated by univariate analysis. Results: The patients were randomly allocated to the 4 arms. No difference in the distribution of comorbidities among the arms was observed (P>.09). The mean ≥G1 and ≥G2 proctitis were 7.8 and 4.9 for placebo and 8.9 and 4.7 for the NABUREN group, respectively. No favorable trend in reduction of incidence, severity, and duration of ≥G1 and ≥G2 proctitis was observed with NABUREN use. In univariate analysis, ≥G1+3d toxicity was found to be related to hemorrhoids (P=.008), and a slight correlation was found between ≥G2 proctitis and hormonal therapy (P=.06). The RT effects on rectal mucosa as based on endoscopic assessment were mainly related to diabetes (P<.01). Endoscopy data at 6 week showed no significant difference between the placebo and butyrate arms. The other investigated endpoints were not correlated with any of the clinical risk factors analyzed. Conclusion: There was no evidence of efficacy of

  2. Hyperbaric Oxygen Treatment in Radiation-Induced Cystitis and Proctitis: A Prospective Cohort Study on Patient-Perceived Quality of Recovery

    Energy Technology Data Exchange (ETDEWEB)

    Oscarsson, Nicklas, E-mail: nicklas.oscarsson@vgregion.se [Department of Anaesthesiology and Intensive Care Medicine, Sahlgrenska Academy, University of Gothenburg and Sahlgrenska University Hospital, Gothenburg (Sweden); Arnell, Per [Department of Anaesthesiology and Intensive Care Medicine, Sahlgrenska Academy, University of Gothenburg and Sahlgrenska University Hospital, Gothenburg (Sweden); Lodding, Pär [Department of Urology, Sahlgrenska Academy, University of Gothenburg and Sahlgrenska University Hospital, Gothenburg (Sweden); Ricksten, Sven-Erik; Seeman-Lodding, Heléne [Department of Anaesthesiology and Intensive Care Medicine, Sahlgrenska Academy, University of Gothenburg and Sahlgrenska University Hospital, Gothenburg (Sweden)

    2013-11-15

    Purpose: In this prospective cohort study, the effects of hyperbaric oxygen treatment (HBOT) were evaluated concerning patient-perceived symptoms of late radiation-induced cystitis and proctitis secondary to radiation therapy for pelvic cancer. Methods and Materials: Thirty-nine patients, 35 men and 4 women with a mean age of 71 (range, 35-84) years were included after informed consent and institutional ethics approval. They had all been treated with radiation therapy for prostate (n=34), cervix (n=2), or rectal (n=3) cancer using external beam radiation at a dose of 25 to 75 Gy. Patients with hematuria requiring blood transfusion were excluded. The HBOT was delivered with 100% oxygen for 90 minutes at 2.0 to 2.4 atmospheres (ATA). Mean number of treatments was 36 (28-40). Symptoms were prospectively assessed using the Expanded Prostate Index Composite score before, during, and 6 to 12 months after HBOT. Results: The HBOT was successfully conducted, and symptoms were alleviated in 76% for patients with radiation cystitis, 89% for patients with radiation proctitis, and 88% of patients with combined cystitis and proctitis. Symptom reduction was demonstrated by an increased Expanded Prostate Index Composite score in the urinary domain from 50 ± 16 to 66 ± 20 after treatment (P<.001) and in the bowel domain from 48 ± 18 to 68 ± 18 after treatment (P<.001). For 31% of the patients with cystitis and 22% with proctitis, there were only trivial symptoms after HBOT. The improvement was sustained at follow-up in both domains 6 to 12 months after HBOT. No severe side effects were observed related to HBOT, and treatment compliance was high. Conclusions: HBOT can be an effective and safe treatment modality for late radiation therapy-induced soft tissue injuries in the pelvic region.

  3. Successful treatment of radiation-induced proctitis pain by blockade of the ganglion impar in an elderly patient with prostate cancer: a case report.

    Science.gov (United States)

    Khosla, Ankur; Adeyefa, Oludayo; Nasir, Syed

    2013-05-01

    Chronic rectal pain secondary to radiation-induced proctitis is fast-becoming a leading cause of chronic pain, especially for prostate cancer survivors. Currently, many elderly patients resort to increased opioid intake to alleviate the pain. However, this increase in opioid consumption often leads to constipation and further aggravates the anorectal pain, thus leading to a perpetual, vicious cycle. We reasoned that blocking the ganglion impar could attenuate this sympathetically maintained pain, which would lead to a reduction in the consumption of opioids, lessen constipation, and lead to an improvement in the patient's quality of life. Case report. An academic tertiary pain management clinic. The authors report the case of a 73-year-old African American man with a history of prostate cancer who presented to the pain management clinic for evaluation and treatment of his chronic anorectal pain secondary to radiation-induced proctitis. The patient underwent a ganglion impar block, using the transcoccygeal technique, and consequently reported excellent pain relief with little or no use for opioid pain medications at a 2-month follow-up. Ultimately, this approach led to improved mobility and an increase in the patient's quality of life. Based on this case's success, a prospective study or randomized control trial evaluating the efficacy of the ganglion impar block as a treatment option for chronic anorectal pain secondary to radiation-induced proctitis appears warranted. Wiley Periodicals, Inc.

  4. The effect of oral sucralfate on the acute proctitis associated with prostate radiotherapy: a double-blind, randomized trial

    International Nuclear Information System (INIS)

    Kneebone, Andrew; Mameghan, Hedy; Bolin, Terry; Berry, Martin; Turner, Sandra; Kearsley, John; Graham, Peter; Fisher, Richard; Delaney, Geoff

    2001-01-01

    Purpose: Acute rectal complications occur in the majority of patients receiving external-beam radiotherapy for carcinoma of the prostate. Sucralfate has been proposed to reduce radiation-induced mucosal injury by forming a protective barrier on ulcer bases, binding local growth factors, and stimulating angiogenesis. However, there is conflicting clinical evidence as to whether sucralfate, taken prophylactically during radiotherapy, can ameliorate the symptoms of acute radiation proctitis. Methods and Materials: A double-blind randomized trial was conducted at four Radiation Oncology Departments in Sydney, Australia, between February 1995 and June 1997. A total of 338 patients with clinically localized prostate cancer receiving small volume radiotherapy, of whom 335 were evaluable, were randomized to receive either 3 g of oral sucralfate suspension or placebo twice a day during radiotherapy. Patients kept a daily record of their bowel symptoms and were graded according to the RTOG/EORTC acute toxicity criteria. Results: One hundred sixty-four patients received sucralfate and 171 received placebo. Both groups were well balanced with regard to patient, tumor, treatment factors, and baseline symptoms, except that the placebo group had a significantly more liquid baseline stool consistency score (p=0.004). Patients kept a daily diary of symptoms during radiotherapy. After adjusting for baseline values, there was no significant difference between the two groups with regard to stool frequency (p=0.41), consistency (p=0.20), flatus (p=0.25), mucus (p=0.54), and pain (p=0.73). However, there was more bleeding in the sucralfate group, with 64% of patients noticing rectal bleeding, compared with 47% in the placebo group (p=0.001). There was no significant difference between the two groups with respect to RTOG/EORTC acute toxicity (p=0.88; sucralfate 13%, 44%, 43% and placebo 15%, 44%, 40% for grade 0, 1, and 2, respectively). Conclusion: This study suggests that oral

  5. Action in the vita activa: Plurality, freedom, power, and the language of Daang Matuwid

    Directory of Open Access Journals (Sweden)

    Joefer Maninang

    2016-01-01

    Full Text Available “A life without speech and without action…is literally dead to the world; it has ceased to be a human life because it is no longer lived among men.” – H. Arendt, The Human Condition In her celebrated philosophical work The Human Condition (HC,woman philosopher - political theorist Johanna “Hannah” Arendt (1906-75 writes in the Prologue, “What I propose, therefore, is very simple: it is nothing more than to think what we are doing.” What we are doing, Arendt reiterates, is the central theme of her philosophical work which investigates the vita activa, a term she uses to designate three fundamental human activities namely labor, work, and action. These activities according to Arendt correspond to the basic human conditions of life, worldliness, and plurality respectively which in turn are under the most general condition of existence: birth and death, natality, and mortality (Arendt, 1998. The central theme “what we are doing” is from where this whole papers reflective expository analysis of the current Philippine government administrations political battle cry of Daang Matuwid or “straight path” - the national anti-corruption campaign or honesty in the government platform proceeds and takes inspiration (Casiple, 2014. As we may have known, Daang Matuwid is executed as a public policy by President Benigno “Noynoy” Aquino III (popularly addressed as “PNoy” for President Noynoy in his legitimate capacity being the highest official of the country. Daang Matuwid is implemented in all branches of the government: the executive, the legislative, the judicial and their departments. It applies to all institutions in their functions, to all offices and their affiliates. Daang Matuwid is mandated to be observed by all government personnel; elected and appointed officials (the president himself included, administrators and staff, and extends to employees of corporations in the public service. Daang Matuwid simply means honesty

  6. Experiencia Uruguaya en Atención Farmacéutica activa en la comunidad

    Directory of Open Access Journals (Sweden)

    Marta Vázquez

    Full Text Available Objetivo: realizar una actividad de difusión a la población sobre el uso racional de medicamentos, mediante la inserción de los estudiantes en el equipo de salud y analizar los datos farmacoterapéuticos obtenidos de esta actividad educativa. Métodos: en la vía pública se instaló una carpa de Atención Farmacéutica durante tres días donde participaron químicos farmacéuticos y médicos, quienes impartieron charlas sobre diferentes temas de salud preponderantes en la población uruguaya. Asimismo, los alumnos de Atención Farmacéutica, como parte de su formación práctica, participaron de esta actividad mediante la realización de entrevistas a los transeúntes, llenado de fichas de perfiles farmacoterapéuticos y de consumo de plantas medicinales, elaboradas para este fin, y la entrega de folletos informativos. A partir de las fichas farmacoterapéuticas se desarrolló un trabajo de investigación. Resultados: los alumnos del curso participaron de forma activa en el llenado de las fichas farmacoterapéuticas y mantuvieron una comunicación fluida con los asistentes a la carpa y con los profesionales de la salud. Se completaron 117 fichas farmacoterapéuticas (90 mujeres y 27 hombres. El 60 % de los entrevistados consumía plantas medicinales. Sesenta personas recibían cuatro o más especialidades farmacéuticas. Las drogas antihipertensivas resultaron las más utilizadas. Veintitrés personas presentaban hipotiroidismo y dos personas de este grupo recibían litio para trastorno bipolar. Entre el grupo de mujeres: 18 tomaban ansiolíticos, 12 antidepresivos, 7 hipnóticos y 2 antisicóticos. Diecinueve personas manifestaron tener colesterol alto y 14 recibían medicación. Catorce presentaban artrosis y 10 estaban en tratamiento con analgésicos. Nueve personas presentaban gastritis, grupo este con un alto consumo de café y mate. Seis mujeres mayores de 50 años, declararon tener osteoporosis y solo tres recibían medicación a base

  7. Local field potential recordings in a non-human primate model of Parkinsons disease using the Activa PC + S neurostimulator

    Science.gov (United States)

    Connolly, Allison T; Muralidharan, Abirami; Hendrix, Claudia; Johnson, Luke; Gupta, Rahul; Stanslaski, Scott; Denison, Tim; Baker, Kenneth B; Vitek, Jerrold L; Johnson, Matthew D

    2016-01-01

    Objective Using the Medtronic Activa® PC + S system, this study investigated how passive joint manipulation, reaching behavior, and deep brain stimulation (DBS) modulate local field potential (LFP) activity in the subthalamic nucleus (STN) and globus pallidus (GP). Approach Five non-human primates were implanted unilaterally with one or more DBS leads. LFPs were collected in montage recordings during resting state conditions and during motor tasks that facilitate the expression of parkinsonian motor signs. These recordings were made in the naïve state in one subject, in the parkinsonian state in two subjects, and in both naïve and parkinsonian states in two subjects. Main results LFPs measured at rest were consistent over time for a given recording location and parkinsonian state in a given subject; however, LFPs were highly variable between subjects, between and within recording locations, and across parkinsonian states. LFPs in both naïve and parkinsonian states across all recorded nuclei contained a spectral peak in the beta band (10–30 Hz). Moreover, the spectral content of recorded LFPs was modulated by passive and active movement of the subjects’ limbs. LFPs recorded during a cued-reaching task displayed task-related beta desynchronization in STN and GP. The bidirectional capabilities of the Activa® PC + S also allowed for recording LFPs while delivering DBS. The therapeutic effect of STN DBS on parkinsonian rigidity outlasted stimulation for 30–60 s, but there was no correlation with beta band power. Significance This study emphasizes (1) the variability in spontaneous LFPs amongst subjects and (2) the value of using the Activa® PC + S system to record neural data in the context of behavioral tasks that allow one to evaluate a subject’s symptomatology. PMID:26469737

  8. Local field potential recordings in a non-human primate model of Parkinsons disease using the Activa PC + S neurostimulator

    Science.gov (United States)

    Connolly, Allison T.; Muralidharan, Abirami; Hendrix, Claudia; Johnson, Luke; Gupta, Rahul; Stanslaski, Scott; Denison, Tim; Baker, Kenneth B.; Vitek, Jerrold L.; Johnson, Matthew D.

    2015-12-01

    Objective. Using the Medtronic Activa® PC + S system, this study investigated how passive joint manipulation, reaching behavior, and deep brain stimulation (DBS) modulate local field potential (LFP) activity in the subthalamic nucleus (STN) and globus pallidus (GP). Approach. Five non-human primates were implanted unilaterally with one or more DBS leads. LFPs were collected in montage recordings during resting state conditions and during motor tasks that facilitate the expression of parkinsonian motor signs. These recordings were made in the naïve state in one subject, in the parkinsonian state in two subjects, and in both naïve and parkinsonian states in two subjects. Main results. LFPs measured at rest were consistent over time for a given recording location and parkinsonian state in a given subject; however, LFPs were highly variable between subjects, between and within recording locations, and across parkinsonian states. LFPs in both naïve and parkinsonian states across all recorded nuclei contained a spectral peak in the beta band (10-30 Hz). Moreover, the spectral content of recorded LFPs was modulated by passive and active movement of the subjects’ limbs. LFPs recorded during a cued-reaching task displayed task-related beta desynchronization in STN and GP. The bidirectional capabilities of the Activa® PC + S also allowed for recording LFPs while delivering DBS. The therapeutic effect of STN DBS on parkinsonian rigidity outlasted stimulation for 30-60 s, but there was no correlation with beta band power. Significance. This study emphasizes (1) the variability in spontaneous LFPs amongst subjects and (2) the value of using the Activa® PC + S system to record neural data in the context of behavioral tasks that allow one to evaluate a subject’s symptomatology.

  9. Análisis de las formaciones dunares activas de la flecha del Fangar (Delta del Ebro)

    OpenAIRE

    Rodríguez, Inmaculada; Sánchez, M. J.; Montoya, I.; Serra, J.; Moreno, L.; Gracia, F.J.; Muñoz-Perez, Juan J.

    2009-01-01

    Este artículo muestra los trabajos realizados sobre los campos de dunas activas de la Flecha del Fangar al amparo del Proyecto de Investigación “Cuantificación y Contribución del Transporte Eólico en los Procesos Dinámicos y Ambientales en el Delta del Ebro. Aplicación a su Gestión Integrada y a la Conservación de los Ambientes Marginales” (AGITE), concedido por el Ministerio de Educación y Ciencia 473 dentro del Plan Nacional de I+D+i (2005-2008). En dicho proyecto se ha po...

  10. Audición activa. Propuesta didáctica para el tercer curso de la etapa primaria

    OpenAIRE

    Marinov Nikolov, Tsvetomir

    2016-01-01

    Con este trabajo se pretende evidenciar la relevancia de la aplicación de la Audición activa en las clases de música para los niños y niñas de la Educación Primaria. Para ello, se ha llevado a cabo una búsqueda exhaustiva sobre todo lo preexistente sobre este tema y a posteriori, se ha creado una propuesta de intervención educativa que consiste en seis actividades mediante las cuales, conseguir nuestro objetivo que es desarrollar las habilidades auditivas de los alumnos. Grado en Educación...

  11. Cambios en el mercado laboral urbano medidos a través de la esperanza de vida activa

    Directory of Open Access Journals (Sweden)

    Virgilio Partida

    2000-01-01

    Full Text Available Este trabajo tiene como objetivo analizar el cambio reciente en los mercados de trabajo urbanos, bajo un enfoque de transiciones, es decir, mediante los movimientos que los individuos realizan entre actividad e inactividad, entre el empleo formal, el informal y el desempleo abierto. Se utilizan los datos de la Encuesta Nacional de Empleo Urbano (ENEU, la única fuente de datos tipo panel que nos permite contabilizar los movimientos de la población económicamente activa e inactiva. Dentro de la gama de indicadores que hacen posible analizar los cambios recientes en el empleo urbano, se selecciona las esperanzas de vida activa, que tienen la virtud de condensar la edad de la inserción de la población en la actividad económica. El estudio parte de la estrategia de descomponer el cambio temporal en las esperanzas de vida en tres factores: mortalidad, propensión a insertarse en la actividad y cambio en los mercados de trabajo.

  12. Celiac disease (CD, ulcerative colitis (UC, and primary sclerosing cholangitis (PSC in one patient: a family study Enfermedad celiaca (EC, colitis ulcerosa (CU y colangitis esclerosante primaria (CEP asociadas en el mismo paciente: estudio familiar

    Directory of Open Access Journals (Sweden)

    V. Cadahía

    2005-12-01

    Full Text Available We discuss the case of a 17-year-old male who at the age of 7 was diagnosed with celiac disease (CD together with ulcerative colitis (UC and primary sclerosing cholangitis (PSC. The patient was treated with gluten-free diet and immunosuppressive drugs (azathioprine, and currently remains asymptomatic. The patient's younger, 12-year-old sister was diagnosed with CD when she was 1.5 years old, and at 7 years she developed type-I diabetes mellitus, which was difficult to control. A family study was made, and both parents were found to be affected with silent CD. All were DQ2 (+. In relation to the case and family study, we provide a series of comments related to CD and its complications.Presentamos el caso de un varón de 17 años, que a la edad de 7 años fue diagnosticado de enfermedad celiaca (EC junto con una colitis ulcerosa (CU y una colangitis esclerosante primaria (CEP asociadas. Fue tratado con DSG e inmuno-supresores tipo azatioprina y se encuentra asintomático en la actualidad. Su hermana menor de 12 años, fue diagnosticada de EC cuando tenía 1,5 años y a los 7 años desarrolló una DM tipo 1 de difícil control. Se realizó un estudio familiar y ambos padres están afectos de una EC silente. Todos ellos son DQ2 (+. A propósito del caso y estudio familiar, se hacen una serie de consideraciones sobre la enfermedad celiaca y el desarrollo de complicaciones.

  13. Efecto de un programa de pausa activa más folletos informativos en la disminución de molestias musculoesqueléticas en trabajadores administrativos

    OpenAIRE

    Cáceres-Muñoz, V. Steffany; Escuela de Terapia Física, Universidad Peruana de Ciencias Aplicadas, Lima, Perú. Fisioterapeuta; Magallanes-Meneses, Antonella; Escuela de Terapia Física, Universidad Peruana de Ciencias Aplicadas, Lima, Perú. Fisioterapeuta; Torres-Coronel, Dafne; Escuela de Terapia Física, Universidad Peruana de Ciencias Aplicadas, Lima, Perú. Fisioterapeuta; Copara-Moreno, Peter; Escuela de Terapia Física, Universidad Peruana de Ciencias Aplicadas, Lima, Perú. Fisioterapeuta magíster en Terapia Manual Ortopédica; Escobar-Galindo, Manuel; Escuela de Terapia Física, Universidad Peruana de Ciencias Aplicadas, Lima, Perú. terapeuta ocupacional; magíster en Ergonomía; Mayta-Tristan, Percy; Escuela de Terapia Física, Universidad Peruana de Ciencias Aplicadas, Lima, Perú. Dirección de Investigación y Desarrollo, Universidad Científica del Sur, Lima, Perú. médico salubrista

    2017-01-01

    Objetivos. Comprobar el efecto de un programa de pausa activa más folletos informativos, en la disminución de molestias musculoesqueléticas en trabajadores administrativos de una institución pública de Lima, Perú. Materiales y métodos. Se realizó un estudio cuasiexperimental con grupo control, no aleatorizado, en dos sedes en una institución pública. El grupo intervención (n=135) recibió folletos informativos una vez por semana, adicionalmente realizó el programa de pausas activas supervisada...

  14. Hyperbaric Oxygen Treatment of Chronic Refractory Radiation Proctitis: A Randomized and Controlled Double-Blind Crossover Trial With Long-Term Follow-Up

    International Nuclear Information System (INIS)

    Clarke, Richard E.; Tenorio, L. M. Catalina; Hussey, James R.; Toklu, Akin S.; Cone, D. Lindsie; Hinojosa, Jose G.; Desai, Samir P.; Dominguez Parra, Luis; Rodrigues, Sylvia D.; Long, Robert J.; Walker, Margaret B.

    2008-01-01

    Purpose: Cancer patients who undergo radiotherapy remain at life-long risk of radiation-induced injury to normal tissues. We conducted a randomized, controlled, double-blind crossover trial with long-term follow-up to evaluate the effectiveness of hyperbaric oxygen for refractory radiation proctitis. Methods and Materials: Patients with refractory radiation proctitis were randomized to hyperbaric oxygen at 2.0 atmospheres absolute (Group 1) or air at 1.1 atmospheres absolute (Group 2). The sham patients were subsequently crossed to Group 1. All patients were re-evaluated by an investigator who was unaware of the treatment allocation at 3 and 6 months and Years 1-5. The primary outcome measures were the late effects normal tissue-subjective, objective, management, analytic (SOMA-LENT) score and standardized clinical assessment. The secondary outcome was the change in quality of life. Results: Of 226 patients assessed, 150 were entered in the study and 120 were evaluable. After the initial allocation, the mean SOMA-LENT score improved in both groups. For Group 1, the mean was lower (p 0.0150) and the amount of improvement nearly twice as great (5.00 vs. 2.61, p = 0.0019). Similarly, Group 1 had a greater portion of responders per clinical assessment than did Group 2 (88.9% vs. 62.5%, respectively; p 0.0009). Significance improved when the data were analyzed from an intention to treat perspective (p = 0.0006). Group 1 had a better result in the quality of life bowel bother subscale. These differences were abolished after the crossover. Conclusion: Hyperbaric oxygen therapy significantly improved the healing responses in patients with refractory radiation proctitis, generating an absolute risk reduction of 32% (number needed to treat of 3) between the groups after the initial allocation. Other medical management requirements were discontinued, and advanced interventions were largely avoided. Enhanced bowel-specific quality of life resulted

  15. Clinical and microbiological aspects of the use of Lactobacillus rhamnosus PL1 strains in proctological patients with symptoms of chronic proctitis.

    Science.gov (United States)

    Borycka-Kiciak, K; Strus, M; Pietrzak, P; Wawiernia, K; Mikołajczyk, D; Gałęcka, M; Heczko, P; Tarnowski, W

    2017-06-30

    Recurrent proctitis and the symptoms associated therewith pose significant clinical problem in proctological patients. The objective of this study was to assess the impact of the probiotic Lactobacillus rhamnosus PL1 strain on the clinical presentation and composition of intestinal microbiota in patients with symptoms of proctitis in the course of hemorrhoidal disease and diverticulosis. Material consisted of 24 patients in whom no complete clinical improvement could be obtained after the treatment of the underlying disease. Subject to the assessment was the presence and the intensity of clinical symptoms as well as qualitative and quantitative changes in the composition of bacterial flora detected in the stool before, during and after a 9-week supplementation with the probiotic Lactobacillus rhamnosus PL1 strain. In the entire study group, the intensity of pain after 12 weeks was significantly lower (p=0,.011) compared to baseline; the intensity of flatulence and abdominal discomfort was reduced significantly as early as after 3 weeks, with the difference reaching a highly significant level after 12 weeks (pP<0,.0001). No significant difference was observed in the frequency of the reported episodes of diarrhea, constipation, as well as itching and burning in the anal region. As early as after 3 weeks of supplementation with the probiotic L. rhamnosus PL1 strain, significant qualitative and quantitative changes were observed in the composition of intestinal microbiota; the changes differed depending on the underlying disease. An increase in the total counts of the bacteria of Lactobacillus genus, particularly L. rhamnosus PL1 strain was observed regardless of the underlying disease. Tthe probiotic Lactobacillus rhamnosus PL1 strain appears to be useful in restoring appropriate ratios of bacterial populations in patients presenting with symptoms of proctitis in the course of the treatment of certain diseases of the lower gastrointestinal tract.

  16. LAS METODOLOGÍAS ACTIVAS Y EL FORO PRESENCIAL: SU CONTRIBUCIÓN AL DESARROLLO DEL PENSAMIENTO CRÍTICO

    Directory of Open Access Journals (Sweden)

    Rosa Inés Lira Valdivia

    2010-01-01

    Full Text Available Este artículo pretende concienciar acerca de la importancia de las metodologías activas y del foro presencial. Ambos términos constituyen estrategias metodológicas aptas para promover el desarrollo del pensamiento crítico en el aula. Mediante la utilización de mecanismos participativos, estas metodologías promueven la eficacia de los mensajes y la asertividad de la comunicación de los estudiantes, durante los procesos de diálogo que se preparan para tal efecto en el aula universitaria. Los hallazgos o formas cognitivas y actitudinales han sido sustentados en un estudio investigativo que sistematizó la opinión y la percepción de los estudiantes en relación con la utilización del foro como metodología que propicia el desarrollo del pensamiento crítico.

  17. Actitudes de docentes y estudiantes de pregrado de medicina hacia la metodologia activa de enseñanza- aprendizaje.

    Directory of Open Access Journals (Sweden)

    Luis Fernando Varela Pinedo

    2009-07-01

    Full Text Available Objetivo: Determinar las actitudes de los docentes y de los estudiantes de pregrado de medicina de una universidad privada de Lima hacia la metodología activa de enseñanza aprendizaje (MAEA. Material y métodos: Investigación no experimental, cuantitativa, descriptiva-comparativa, realizada a 188 estudiantes de cuarto y sétimo año de pregrado de medicina y a 72 docentes. Se utilizó una encuesta utilizando la escala tipo Likert validada mediante juicio de expertos y una confiabilidad de 0,71 por alfa de Combrach. Resultados: Se encontró una actitud positiva hacia la MAEA en 65,2% de los estudiantes y en el 78,5% de los docentes (p<0,001. En comparación con los estudiantes, se encontró una mayor proporción de docentes con actitud positiva hacia la MAEA en todas las dimensiones y los roles de forma significativa (p<0,001. Se encontró asociación entre una mayor actitud positiva del docente hacia la MAEA con el mayor tiempo de docencia y con la experiencia previa con métodos participativos (p<0,05. Conclusiones: La actitud positiva hacia la metodología activa de enseñanza aprendizaje (MAEA fue 78,5% en docentes y 65,2% en estudiantes, siendo la diferencia estadísticamente significativa. La actitud positiva hacia la MAEA de docentes y estudiantes fueron significativamente diferentes al considerar las dimensiones y roles. Hubo asociación significativa entre la actitud positiva hacia la MAEA de docentes en relación a su tiempo de docencia y a la experiencia previa. (Rev Med Hered 2009;20:162-168.

  18. Cribado de cáncer de cérvix: ¿merece la pena la búsqueda activa?

    Directory of Open Access Journals (Sweden)

    Ángeles Morales Martínez

    2015-12-01

    Conclusiones: En nuestra población existe una alta cobertura del cribado oportunista de cáncer de cérvix. La captación activa de mujeres que se encontraban fuera del programa de cribado no resultó rentable.

  19. ASPECTOS DIFERENCIALES EN LA IMAGEN CORPORAL Y LA AUTODESCRIPCIÓN DE LA FORMA FÍSICA EN MUJERES SEDENTARIAS VS. MUJERES ACTIVAS DEPORTIVAMENTE

    Directory of Open Access Journals (Sweden)

    F. Arbinaga Ibarzábal

    2010-10-01

    Full Text Available

     

    Se analizan las relaciones entre imagen corporal y autodescripción física en mujeres que practican danza aeróbica de forma amateur frente a un grupo de mujeres sedentarias.
    La muestra se compuso de 112 mujeres activas deportivamente y 51 mujeres sedentarias.
    Los resultados al “Body Shape Questionnaire” (B.S.Q indican que no se presentan diferencias significativas entre las mujeres sedentarias y las mujeres activas. Del conjunto de la muestra, el 18,4% de las mujeres presentaría problemas con la imagen corporal; siendo en las sedentarias el 19,6% y en las activas el 17,9%. Al valorar los resultados en el “Physical Self-Description Questionnaire” (P.S.D.Q, las mujeres sedentarias puntúan por debajo de las activas en todos los factores salvo en el de fuerza.
    Palabras Clave: imagen corporal, forma física, aeróbic, mujer, sedentarias.

  20. Is argon plasma coagulation an effective and safe treatment option for patients with chronic radiation proctitis after high doses of radiotherapy?

    Directory of Open Access Journals (Sweden)

    Eduardo Hortelano

    Full Text Available Introduction: In severe cases refractory to medical treatment, APC appears to be the preferred alternative to control persistent rectal bleeding of patients with chronic radiation proctitis. Although successful outcomes have been demonstrated in patients previously treated with moderate doses of radiotherapy, there is reluctance towards its indication due to the concern of severe adverse events in patients treated with high doses of radiation. Objectives: The aim of this study was to assess the efficacy and toxicity of APC in the management of bleeding radiation-induced proctitis in patients treated with high doses of radiation for prostate cancer. Methods and materials: Data from 30 patients were treated with APC due to chronic radiation proctitis, were reviewed retrospectively. All cases had prostate cancer and 9 of them (30 % underwent previous radical prostatectomy. The median dose of conformal 3D External Beam Radiotherapy (EBRT delivered was 74 Gy (range 46-76. Median rectal D1cc and D2cc was 72.5 and 72.4 Gy respectively. Median rectal V70, V60 and V40 was 12, 39.5 and 80 %. Cardiovascular and digestive disease, diabetes, smoking behaviour, lowest haemoglobin and transfusion requirements were recorded. Indications for treatment with APC were anemia and persistent bleeding despite medical treatment. Argon gas flow was set at 1.8 l/min with an electrical power setting of 50 W. Results: Median age of all patients was 69.6 years. The median lowest haemoglobin level was 9.6 g/dL. Median time between completion of radiotherapy and first session of APC was 13 months. Ninety-four therapeutic sessions were performed (median 3 sessions. Median time follow-up was 14.5 months (range 2-61. Complete response with resolved rectal bleeding was achieved in 23 patients (77 %, partial response in 5 (16 % and no control in 2 (6 %. No patients required transfusion following therapy. Two patients developed long-term (> 6 weeks grade 2 rectal ulceration and

  1. Epidermal growth factor enemas for induction of remission in left-sided ulcerative colitis Enemas de factor de crecimiento epidérmico para inducir la remisión de la colitis ulcerosa izquierda

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    Hugo Nodarse-Cuní

    2013-03-01

    Full Text Available Introduction: ulcerative colitis is a little known chronic inflammatory disease in colonic mucosa. The positive effect of epidermal growth factor was shown in a previous report, with enema use for treatment of mild to moderate left-sided manifestation of the disease. This evidence provided the basis for evaluating the efficacy and safety profile of a viscous solution of this product. Methods: thirty-one patients were randomized to three groups for daily medications during 14 days. Twelve received one 10 mg enema of epidermal growth factor dissolved in 100 mL of viscous solution whereas nine were treated with placebo enema; both groups also received 1.2 g of oral mesalamine per day. The other group included ten patients with 3 g / 100 mL of mesalamine enema. Primary end point was clinical responses after two weeks of treatment, defined as a decreased of, at least three points from baseline, the Disease Activity Index and endoscopic or histological evidences of improvement. Results: remission of disease was observed in all patients in the epidermal growth factor group, and six in both, mesalamine enema and placebo group. All the comparisons between groups showed statistically significant superiority for epidermal growth factor, the only product with significant reduction in disease activity index as well as the presence and intensity of digestive symptoms in patients after treatment. None adverse event was reported. Conclusions: the results agree with previous molecular and clinical evidences, indicating that the epidermal growth factor is effective to reduce disease activity and to induce remission. A new study involving more patients should be conducted to confirm the efficacy of the epidermal growth factor enemas.Introducción: la colitis ulcerosa es una enfermedad inflamatoria crónica de etiología poco conocida, que afecta la mucosa del colon. El efecto positivo del factor de crecimiento epidérmico fue reportado en estudio previo con uso de

  2. Estudio multicéntrico sobre actitudes y normas culturales frente a la violencia (proyecto ACTIVA: metodología Multicenter study: cultural norms and attitudes toward violence (ACTIVA project: methodology

    Directory of Open Access Journals (Sweden)

    Marco Fournier

    1999-04-01

    Full Text Available El propósito de este artículo es describir las bases conceptuales y los métodos empleados en el estudio multicéntrico ACTIVA, así como el proceso que se cumplió en las diferentes etapas de la investigación. Se brinda información general sobre el enfoque, diseño y métodos que se aplicaron en las ciudades que participaron en el estudio: San Salvador, El Salvador; San José, Costa Rica; Cali, Colombia; Caracas, Venezuela; Salvador de Bahía y Río de Janeiro, Brasil; Santiago, Chile y Madrid, España. Los objetivos del estudio fueron: 1 analizar y comparar entre ciudades la prevalencia de conductas agresivas verbales y físicas hacia los niños, la pareja y personas que no son miembros de la familia; y 2 identificar factores personales, ambientales y socioeconómicos asociados con estas conductas violentas. El propósito del proyecto ACTIVA fue generar información que ayudara a orientar políticas y programas para la prevención de la violencia en las ciudades y brindar criterios para la toma de decisiones, así como recabar información que sirviera de base para evaluar políticas y programas de prevención. Para cumplir con los objetivos propuestos se procedió a elaborar y validar un cuestionario común, que se aplicó, mediante el método de entrevista cara-cara, a los residentes de hogares particulares urbanos entre los 18 y 70 años de edad. La muestra fue seleccionada en cada ciudad mediante un muestreo multietápico, estratificado y por conglomerados, y proporcionada según los estratos socioeconómicos y la densidad de la población y sin reemplazo o sustitución. La muestra final estuvo compuesta por 10821 personas. En general, los porcentajes de respuesta se encontraron comprendidos entre los límites establecidos, salvo algunas excepciones. En San José, Río de Janeiro y Madrid el tamaño de la muestra final fue ligeramente menor del esperado. Se registraron mayores rechazos en varones jóvenes adultos de los estratos altos

  3. Evaluación de la conducta activa: el Registro Semanal de Actividad Física (RSAF

    Directory of Open Access Journals (Sweden)

    Eva Parrado

    2009-01-01

    Full Text Available El objetivo de este estudio es proponer el Registro Semanal de Actividad Física (RSAF como un instrumento para evaluar detalladamente la conducta activa en adultos. Para ello, se ha administrado el RSAF en un total de 132 adultos (media= 28,53 años; DT= 11,20 a partir del cual se ha determinado el consumo energético (en METs de las actividades físicas cotidianas durante una semana y se han calculado los percentiles del consumo energético promedio semanal en función del género y la edad. El consumo energético se ha comparado con el nivel de actividad física y con la condición física saludable. Los resultados muestran que los participantes activos tienden a tener un mayor consumo energético y que la condición física cardiorrespiratoria correlaciona significativamente con el consumo energético promedio semanal. Estos resultados muestran que el RSAF es un instrumento útil y adecuado para evaluar el nivel de actividad física diaria y de condición física saludable en población adulta.

  4. Patología y terapéutica de las armaduras activas en el hormigón pretensado

    Directory of Open Access Journals (Sweden)

    Elices Calafat, Manuel

    1988-08-01

    Full Text Available Steels for prestressing concrete may have diseases along their life; its diagnosis and therapeutics are the subject of this paper Three stages may be considered: Prenatal, where the steel wire is born from cold-drawing a suitable steel bar. Adolescence, the period from manufacturing to final stressing the concrete, and Maturity, the whole period of serviceability of the prestressed concrete structure.

    En este artículo se comentan algunas enfermedades que pueden sufrir las armaduras activas a lo largo de su vida, su diagnóstico y la forma de curarlas. Para ello se contemplan tres etapas: la Prenatal, o etapa de fabricación del alambre trefilado a partir del alambrón. La etapa de Adolescencia, que es el período que va desde la fabricación hasta que el alambre empieza a trabajar, integrándose en el hormigón para comprimirlo. Y la tercera etapa, la de Madurez, que coincide con la etapa de servicio de la obra pretensada.

  5. Mujer, exclusión social y renta activa de inserción. Especial referencia a las víctimas de violencia de género. Women, social exclusion and renta activa de inserción benefit payment. Special reference to the protection of victims of gender violence

    Directory of Open Access Journals (Sweden)

    Josep Moreno Gené

    2009-12-01

    Full Text Available En este estudio se aborda la protección que recibe la mujer ante situaciones de pobreza y exclusión social en la renta activa de inserción con la finalidad de analizar si el tratamiento dispensado es el adecuado o si, por el contrario, ante la insuficiencia de la protección recibida debe procederse a un replanteamiento de esta prestación. Para ello, se analiza tanto el tratamiento que con carácter general se prevé para la mujer en la renta activa de inserción como la regulación contenida en la misma específicamente para el supuesto de las mujeres víctimas de violencia de género. Normal 0 21 false false false MicrosoftInternetExplorer4 This study deals with the protection afforded to women against poverty and social exclusion by the benefit payment known as the renta activa de inserción. It aims to analyze whether the measure is sufficient and, if it is not, whether it needs to be rethought. To this end, both the general provisions envisaged for women by the renta activa de inserción and the specific regulations for those cases of women who are victims of gender violence are analyzed.

  6. EFECTOS DE UN PROGRAMA DE AQUAEROBIC SOBRE LA COMPOSICIÓN CORPORAL, EN LAS MUJERES ACTIVAS DE MEDIANA EDAD

    Directory of Open Access Journals (Sweden)

    Asunción Grager

    2011-07-01

    Full Text Available Objetivo: Describir y analizar las modificaciones en la composición corporal, en las mujeres de mediana edad, después de realizar un programa de actividad física, basado en el aquaerobic, y un posterior periodo de desentrenamiento. Material y método: El grupo analizado estuvo integrado por diecisiete mujeres de Arroyo de San Serván (Badajoz, físicamente activas (habían realizado programas de gimnasia de mantenimiento, con una frecuencia de una a tres sesiones semanales, durante los últimos tres meses, con una edad media de 53,6 ± 9,1 años. El programa se desarrolló con sesiones de sesenta minutos durante cinco días a la semana, por seis semanas, con un periodo de desentrenamiento de cuatro semanas. Se realizaron tres evaluaciones antropométricas: al iniciar el programa, al finalizar el mismo, tras el periodo de desentrenamiento. En cada medición, se determinaban la talla y el peso, seis pliegues cutáneos, cuatro perímetros corporales y tres diámetros óseos. El porcentaje de grasa fue obtenido a través de los datos arrojados en cuatro pliegues cutáneos (tricipital, subescapular, suprailíaco y abdominal mediante la fórmula de Yuhasz, modificada por Faulkner (1968. Por su parte, el porcentaje muscular fue calculado, a partir del porcentaje de la masa total, menos el porcentaje óseo (Rocha, 1975, el porcentaje graso (Faulkner, 1968 y el porcentaje residual, a través de la ecuación de Wurch (Esparza, 1993, de los sujetos medidos, según la propuesta básica de Matiegka (modelo de los cuatro componentes. Resultados: después de realizar el programa, se observó un aumento significativo en el porcentaje muscular: 32.69 ± 2.69% vs. 33.44 ± 2.89% (p < 0.05, en el peso muscular: 23.45 ± 3.53 kg vs. 24.02 ± 3.33 kg (p <0.05, y un descenso significativo del componente graso reflejado, mediante el sumatorio de pliegues cutáneos: 193.66 ± 25.54 mm vs. 188.38 ± 25.67 mm (P <0,05, más específicamente, en el pliegue suprail

  7. Teología de la evolución (I: La autotrascendencia activa. Karl Rahner, 1961

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    Manuel G. Doncel

    2015-03-01

    Full Text Available Este artículo es el primero de una tríada en la que se presentarán tres intuiciones que creemos valiosas para elaborar hoy día una rica teología de la «creación en evolución» (las otras dos serán: 2. La llamada creativa trinitaria, según Karl Schmitz-Moormann, 1997, y 3. El Espíritu como fuente de novedad, según Denis Edwards, 2004. Quisiéramos entender, a nivel filosófico y teológico, esa «cosmo-bio-evolución» que es nuestra propia «mega historia». Comenzamos hoy por preguntarnos cómo explicar el progreso evolutivo en que de la materia parece emerger la espiritualidad humana. Es un problema filosófico (¿puede de lo menos salir lo más? y teológico (¿cómo concebir una acción creadora y respetuosa con la creación?. Para resolverlo creemos necesario apoyarnos en la intuición de Rahner de 1961, de la que recogemos con concisión didáctica el núcleo central de su documento fundamental de 1961 sobre la «autosuperación» o «autotrascendencia activa» en relación a la hominización. Buscamos a continuación el contexto y la fecha en que se elaboró originalmente esa intuición, analizando tres documentos de Rahner inmediatamente anteriores y relacionados con el fundamental, y deducimos que la intuición hubo de tener lugar prácticamente en 1960. Presentamos por fin algunos artículos poco posteriores al de Rahner 1961, que difundieron positivamente sus ideas centrales, así como algunos otros que las critican, y enumeramos algunas publicaciones ulteriores de Rahner que clarifican su pensamiento.

  8. Reconexión magnética en una región activa en decaimiento

    Science.gov (United States)

    Mandrini, C. H.; Démoulin, P.; van Driel-Gesztelyi, L.; Schmieder, B.; Bagalá, L. G.; Rovira, M. G.

    Se han obtenido observaciones desde Tierra (Hα y magnetogramas) coordinadas con el Soft X-ray Telescope (SXT), a bordo del satélite japonés Yohkoh, de una región activa bipolar en decaimiento. Estos datos constituyen la base para el estudio de un punto brillante en rayos X (PBX) y de la actividad relacionada con el mismo en distintas capas de la atmósfera solar. Las observaciones muestran que el PBX está relacionado con la aparición de un bipolo menor (~ 1020 Mx) y que su abrillantamiento continuo, así como sus aumentos de brillo esporádicos (``fulguraciones"), son el resultado de la reconexión entre el pequeño arco emergente (visto en Hα como un sistema de filamentos arqueados, SFA) y arcos mayores asociados al campo facular preexistente. Se ha extrapolado el campo magnético observado en la aproximación libre de fuerzas lineal y se ha seguido su evolución a lo largo de la vida del PBX. Se ha calculado la posición de las cuasiseparatrices (CSs) a partir del campo modelado. Las líneas de campo extrapoladas, cuyas bases fotosféricas se encuentran a ambos lados de las CSs, están de acuerdo con las estructuras cromosféricas y coronales observadas. Se ha calculado el espesor de la CD ubicada a lo largo de la polaridad negativa emergente, encontrándose que su variación está de acuerdo con la evolución de la intensidad del PBX; la CS es muy delgada durante la vida del PBX (~ 100 m), mientras que su espesor aumenta considerablemente (>= 10^4 m) cuando el PBX desaparece de las imágenes del SXT. Estos resultados señalan que el abrillantamiento y las ``fulguraciones" de este PBX se deben al proceso de reconexión en 3D que tiene lugar en las CSs.

  9. Efecto de un programa de pausa activa más folletos informativos en la disminución de molestias musculoesqueléticas en trabajadores administrativos

    Directory of Open Access Journals (Sweden)

    V. Steffany Cáceres-Muñoz

    Full Text Available RESUMEN Objetivos Comprobar el efecto de un programa de pausa activa más folletos informativos, en la disminución de molestias musculoesqueléticas en trabajadores administrativos de una institución pública de Lima, Perú. Materiales y métodos Se realizó un estudio cuasiexperimental con grupo control, no aleatorizado, en dos sedes en una institución pública. El grupo intervención (n=135 recibió folletos informativos una vez por semana, adicionalmente realizó el programa de pausas activas supervisadas, las cuales consistían en ejercicios de respiración, estiramiento y calentamiento. El grupo control (n=127 solo recibió folletos informativos una vez por semana. Se midió la frecuencia e intensidad de molestias musculoesqueléticas en los últimos siete días. Resultados La edad promedio fue 38 años. Los segmentos más afectados fueron el cuello y dorso lumbar. El grupo intervención redujo 20% la frecuencia de molestias musculoesqueléticas en cuello en los últimos siete días (p<0,001 y 17% en la zona dorso lumbar (p<0,001, el grupo control solo redujo la frecuencia en la zona dorso lumbar (p=0,029. Respecto a intensidad del dolor, el grupo de intervención tuvo mayor disminución en todos los segmentos evaluados (p<0,05. Conclusiones Las pausas activas supervisadas más folletos informativos lograron disminuir las molestias musculoesqueléticas en trabajadores administrativos. Por ello, puede ser implementado en otras instituciones públicas o privadas.

  10. Nuevas herramientas para facilitar la respuesta activa de consumidores en mercados eléctricos liberalizados: implementación y retribución

    OpenAIRE

    Escrivá Escrivá, Guillermo

    2011-01-01

    En la nueva situación en la que se encuentran los mercados eléctricos, inmersos en distintos procesos de liberalización, toma especial importancia la competitividad dentro del sector del suministro eléctrico. Dicha competitividad debe considerar todos los mecanismos posibles para conseguir una gestión óptima de los mismos, tanto técnica como económica. Dentro de estos mercados, la participación activa del consumidor se define como uno de los objetivos fundamentales para conseguir un funcionam...

  11. Influencia de la geometría de techumbres de vivienda unifamiliar para integración de energía solar activa (BIPYTA)

    OpenAIRE

    Zalamea, Esteban Felipe; García, Rodrigo Hernán; Sánchez Arriagada, Reinaldo

    2016-01-01

    Este trabajo fue parte de programa de investigación Conicyt CONFIN AKA-ERNC 007, (Chile, Conicyt 912, 2013). Se revisa la integración arquitectónica de sistemas de energía solar activa (colectores híbridos con aire) en techumbres de viviendas unifamiliares recientes en Concepción, Chile, determinando la influencia de la composición volumétrica de faldones captadores. Se descifra la incidencia de orientación e inclinación respecto a trayectoria solar, considerando que si bien es recomendab...

  12. Aplicación y Comparación de Metodologías Activas en la Enseñanza de un Tema de Ciencias Naturales

    OpenAIRE

    Restrepo Solarte, Nefiz

    2014-01-01

    Este trabajo pretende mejorar la calidad de aprendizaje, a través del estudio de un tema específico de las Ciencias Naturales: “los Ecosistemas”; empleando para ello, metodologías de enseñanza-aprendizaje activas. Para su desarrollo, esta investigación se realizó en la Sede Principal de la Institución Educativa General Santander, ubicada en el Corregimiento de Villa-Colombia, Municipio de Jamundí, con dos grupos de estudiantes de grado séptimo; en un grupo se trabajó con un enfoque cooperativ...

  13. LA PROBLEMÁTICA DE LAS PARTES Y EL CONTENIDO DE LA LEGITIMACIÓN ACTIVA EN LA CUESTIÓN DE INAPLICABILIDAD POR INCONSTITUCIONALIDAD DE LA LEY

    OpenAIRE

    Pica Flores, Rodrigo

    2010-01-01

    El presente trabajo aborda la justificación y el contenido de la legitimación activa en el proceso de inaplicabilidad por inconstitucionalidad de la ley en Chile, en una perspectiva de contexto de un sistema concentrado y concreto, para llegar posteriormente a la diferenciación entre la iniciativa de parte y la que corresponde a juez que conoce del proceso a quo. Se busca justificar la legitimación del juez de la causa, alternativa con la de las partes, pasando por la identificación y conteni...

  14. Development of a European Organization for Research and Treatment of Cancer Module to Assess the Quality of Life of Patients With Proctitis After Pelvic Radiotherapy for Malignancy

    International Nuclear Information System (INIS)

    Spry, Nigel; Halkett, Georgia; Aoun, Samar; Spry, Jane; Yeoh, Eric

    2008-01-01

    Purpose: To describe the development of a proctitis-specific quality-of-life module to supplement the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30). Methods and Materials: The module was developed according to EORTC guidelines, which consisted of an extensive literature review to identify previously described issues and interviews conducted with seven health professionals and 10 patients to rationalize the item list for construction into a provisional module. The module developed was then pretested with 28 patients and five health professionals. Results: The final module contains 21-items that are suitable to obtain information about the patients' quality of life after high-dose pelvic irradiation. The questionnaire has now been translated into four languages and commenced field testing in late 2007. Conclusions: The EORTC QLQ-C30, supplemented by EORTC QLQ-PRT21, will enable health professionals to more accurately monitor the side effects that patients experience after pelvic irradiation

  15. La productividad de la población económicamente activa (PEA en México: historia, panorama actual y perspectiva

    Directory of Open Access Journals (Sweden)

    Ernesto Felipe Peralta Solorio

    2016-01-01

    Full Text Available El artículo da una perspectiva de la relación entre la población económicamente activa (PEA y el Producto Interno Bru - to (PIB en México de 1895 a 2015, ya que la dimensión y estructura de aquélla inciden en éste; el objetivo es estimar la productividad laboral con los datos disponibles y plantear algunos ajustes para tener estimadores confiables. Hay cinco fases: la primera dimensiona la pea ; la segunda la liga con el crecimiento económico; la tercera señala deficiencias en la medición de la pea ; la cuarta es de prospectiva para PEA, PIB y ocupación; la quinta es de conclusiones y recomendaciones. Se infiere que la productividad crece hasta el inicio de los 1980, luego desciende en perspectiva conflictiva; a mediano y corto plazo se le estima estadísticamente con resultados congruentes; y se sugiere que la pea se mida en años de vida activa para tener una mejor estimación de la fuerza de trabajo.

  16. Comportamiento de las fracciones activas del fósforo inorgánico en los vertisoles crómicos de Holguín.

    Directory of Open Access Journals (Sweden)

    Yakelin Cobo-Vidal

    2013-07-01

    Full Text Available La investigación se realizó con la información de 40 perfiles de suelo de un vertisol crómico, en áreas cultivadas con caña de azúcar de la Empresa Azucarera Holguín. Se tomaron las determinaciones analíticas correspondientes a las fracciones activas del fósforo inorgánico (P-Ca, P-Fe, P-Al, P-total y el fósforo asimilable por el método de Oniani, a las profundidades 0-25, 25-50, 50-75 y 75-100 cm. Los resultados mostraron un bajo nivel del P- total con una progresiva disminución de la profundidad del perfil, P-Ca es la fracción dominante en estos suelos, lo que indica un bajo nivel de meteorización del perfil, P-Fe y P-Al a diferencia de P-Ca disminuyen con la profundidad. La relación de las fracciones activas con el pH, demostró que P-Ca aumenta, a medida que lo hace el pH, una relación inversa mostró el fósforo ligado a las fracciones (P-Fe y P-Al.

  17. Mujer, exclusión social y renta activa de inserción. Especial referencia a las víctimas de violencia de género

    OpenAIRE

    Moreno Gené, Josep; Romero Burillo, Ana Maria

    2009-01-01

    En este estudio se aborda la protección que recibe la mujer ante situaciones de pobreza y exclusión social en la renta activa de inserción con la finalidad de analizar si el tratamiento dispensado es el adecuado o si, por el contrario, ante la insuficiencia de la protección recibida debe procederse a un replanteamiento de esta prestación. Para ello, se analiza tanto el tratamiento que con carácter general se prevé para la mujer en la renta activa de inserción como la regulación contenida en l...

  18. The Value of Botox-A in Acute Radiation Proctitis: Results From a Phase I/II Study Using a Three-Dimensional Scoring System

    International Nuclear Information System (INIS)

    Vuong, Te; Waschke, Kevin; Niazi, Tamim; Richard, Carole; Parent, Josee; Liberman, Sender; Mayrand, Serge; Loungnarath, Rasmy; Stein, Barry; Devic, Slobodan

    2011-01-01

    Purpose: Acute radiation proctitis (ARP) is a common side effect of pelvic radiotherapy, and its management is challenging in daily practice. The present phase I/II study evaluates the safety and efficacy of the botulinum toxin A (BTX-A) in ARP treatment for rectal cancer patients undergoing neoadjuvant high-dose-rate endorectal brachytherapy (HDREBT). Methods and Materials: Fifteen patients, treated with neoadjuvant HDREBT, 26-Gy in 4 fractions, received the study treatment that consisted of a single injection of BTX-A into the rectal wall. The injection was performed post-HDREBT and prior to the development of ARP. The control group, 20 such patients, did not receive the BTX-A injection. Both groups had access to standard treatment with hydrocortisone rectal aerosol foam (Cortifoam) and anti-inflammatory and narcotic medication. The ARP was clinically evaluated by self-administered daily questionnaires using visual analog scores to document frequency and urgency of bowel movements, rectal burning/tenesmus, and pain symptoms before and after HDREBT. Results: At the time of this analysis, there was no observed systemic toxicity. Patient compliance with the self-administered questionnaire was 100% from week 1 to 4, 70% during week 5, and 40% during week 6. The maximum tolerated dose was established at the 100-U dose level, and noticeable mean differences were observed in bowel frequency (p = 0.016), urgency (p = 0.007), and pain (p = 0.078). Conclusions: This study confirms the feasibility and efficacy of BTX-A intervention at 100-U dose level for study patients compared to control patients. A phase III study with this dose level is planned to validate these results.

  19. Análisis de las consecuencias de asociar un elemento elástico a una ortesis activa de rodilla

    OpenAIRE

    Capsi Morales, Patricia

    2015-01-01

    Este trabajo presenta las consecuencias de incorporar un elemento elástico al actuador de una ortesis activa de rodilla. Para ello, se realiza el análisis dinámico de un modelo biomecánico con distintos diseños para el sistema de actuación de la ortesis de rodilla integrada. Con la finalidad de estudiar las ventajas y desventajas debidas a su incorporación, se determina la dinámica de cada diseño y se realiza una comparación sobre los parámetros relevantes en el ámbito. El estudio se enmar...

  20. Educación viva y activa para las matemáticas de primaria: proyecto de aula partiendo del libro de texto

    OpenAIRE

    González-Avià, Miriam

    2016-01-01

    En la actualidad, el peso principal de la metodología educativa de la gran mayoría de escuelas de Cataluña recae sobre el libro de texto, aspecto que no va a cambiar, al menos de hoy a mañana. Sin embargo, la educación viva y activa parte de la necesidad de poner la propia experimentación del alumno en el lugar que hoy ocupa el libro de texto (Canals, 2008). El objetivo general de este trabajo fue profundizar sobre la introducción de un método de enseñanza-aprendizaje más vivo y activo en el ...

  1. La evaluación participativa de un programa de formación para una participación activa e intercultural

    OpenAIRE

    Folgueiras Bertomeu, Pilar

    2007-01-01

    Este artículo parte de las bases teóricas y metodológicas fundamentales para la elaboración, aplicaciónes y evaluación de un programa de formación para una participación activa e intercultural específicamente diseñado para mujeres. El programa sigue una metodología de evaluación participativa, que incluye la participación de los sujetos en todo el proceso de la evaluación. Presentamos un modelo de evaluación participativa: la evaluación diagnóstica que incluye el origen del proyecto, un análi...

  2. La comunicación participativa como herramienta generadora de ciudadanía activa en la niñez

    OpenAIRE

    Sánchez Castiblanco, John Richard

    2016-01-01

    La presente tesis doctoral tiene como propósito analizar y evaluar el uso de la comunicación como una herramienta de participación y empoderamiento de la niñez, que a su vez posibilite la formación y el desarrollo de la ciudadanía activa de las niñas y los niños. Toma como objeto de estudio una intervención sociocomunicativa que se realizó con un grupo de niñas y niños de una zona vulnerable de la periferia de la ciudad de Bogotá. Esta intervención se basó en un proyecto de televisión con la ...

  3. Double-blind, placebo-controlled evaluation of 5-ASA suppositories in active distal proctitis and measurement of extent of spread using /sup 99m/Tc-labeled 5-ASA suppositories

    International Nuclear Information System (INIS)

    Williams, C.N.; Haber, G.; Aquino, J.A.

    1987-01-01

    Patients with active distal proctitis received either 5-aminosalicylic (5-ASA) acid or identical placebo suppositories, 500 mg t.i.d. for 6 weeks. Activity at 3 and 6 wks was assessed using a Disease Activity Index (DAI), derived from four categories: number of daily evacuations more than usual, evacuations containing blood, sigmoidoscopy appearance, and physician's overall assessment. Each category was graded 0-3. There was thus 0-12 points scored ranging from complete remission to severe disease. A minimum score of 3 from two categories was necessary for study entry. Of 27 patients randomized, 14 received active medication and 13 placebo. Of the 14 patients, with initial mean DAI 7.1 +/- 1.8, 11 were in complete remission at 6 wks (78.6%). Whereas, there was no significant change in the placebo group, with initial mean DAI 7.1 +/- 1.8. An additional 6 patients with inflammatory bowel disease and 6 healthy volunteers were given /sup 99m/Tc-labelled 5-aminosalicylic acid suppositories. The extent of spread was limited to the rectum, and the suppositories were retained for 3 hours. There was no absorbed radioactivity. 5-ASA suppositories are safe, well-tolerated, and effective treatment for active distal proctitis

  4. Double-blind, placebo-controlled evaluation of 5-ASA suppositories in active distal proctitis and measurement of extent of spread using /sup 99m/Tc-labeled 5-ASA suppositories

    Energy Technology Data Exchange (ETDEWEB)

    Williams, C.N.; Haber, G.; Aquino, J.A.

    1987-12-01

    Patients with active distal proctitis received either 5-aminosalicylic (5-ASA) acid or identical placebo suppositories, 500 mg t.i.d. for 6 weeks. Activity at 3 and 6 wks was assessed using a Disease Activity Index (DAI), derived from four categories: number of daily evacuations more than usual, evacuations containing blood, sigmoidoscopy appearance, and physician's overall assessment. Each category was graded 0-3. There was thus 0-12 points scored ranging from complete remission to severe disease. A minimum score of 3 from two categories was necessary for study entry. Of 27 patients randomized, 14 received active medication and 13 placebo. Of the 14 patients, with initial mean DAI 7.1 +/- 1.8, 11 were in complete remission at 6 wks (78.6%). Whereas, there was no significant change in the placebo group, with initial mean DAI 7.1 +/- 1.8. An additional 6 patients with inflammatory bowel disease and 6 healthy volunteers were given /sup 99m/Tc-labelled 5-aminosalicylic acid suppositories. The extent of spread was limited to the rectum, and the suppositories were retained for 3 hours. There was no absorbed radioactivity. 5-ASA suppositories are safe, well-tolerated, and effective treatment for active distal proctitis.

  5. Efficacy and safety of argon plasma coagulation for the treatment of hemorrhagic radiation proctitis Eficacia y seguridad de la electrocoagulación con plasma de argón en el tratamiento del sangrado rectal secundario a proctitis por radioterapia

    Directory of Open Access Journals (Sweden)

    C. de la Serna Higuera

    2004-11-01

    Full Text Available Objective: to evaluate the efficacy, safety and medium-/long-term clinical course of patients undergoing endoscopic treatment with argon plasma coagulation for hemorrhagic radiation proctopathy. Design: descriptive, retrospective study with medium- and long-term follow-up. Patients, material and methods: ten patients were treated with argon plasma coagulation for hemorrhagic radiation proctopathy between July 1998 and February 2003. Inclusion criteria were: evidence of chronic rectal bleeding, consistent endoscopic findings, and absence of any other cause of hematochezia after a comprehensive ano-rectal examination and complete colonoscopy. The equipment used was a standard colonoscope, an argon delivery unit, an argon plasma coagulation probe 1.5 mm in internal diameter, and a high-frequency electrosurgical generator. Consecutive treatment sessions were programmed whenever it was considered necessary until all mucosal lesions had been treated. Clinical and evolutive follow-up was performed with a focus on tolerance, efficacy, and potential argon plasma coagulation-related complications. Data were updated by personal or telephonic interview. Results: in all patients, chronic rectal bleeding stopped after the last treatment session. The mean number of treatment sessions to stop symptoms was 1.7. Mean follow-up was 31.1 months. All sessions were well tolerated, similarly to standard rectoscopy. In one case a recurrence of rectal bleeding was observed four months later, which required two repeat sessions. Four patients were anemic at inclusion. Three of them reported a resolved anemia at the end of the study. No delayed argon plasma coagulation-related complications such us ulcers or strictures were seen. Conclusions: argon plasma coagulation appears to be a useful, effective and safe treatment for rectal bleeding resulting from chronic radiation proctitis when compared to standard medical and endoscopic treatments. These successful outcomes seem

  6. Up-Regulation of Endothelin Type A Receptor in Human and Rat Radiation Proctitis: Preclinical Therapeutic Approach With Endothelin Receptor Blockade

    International Nuclear Information System (INIS)

    Jullien, Nicolash; Blirando, Karl; Milliat, Fabien; Sabourin, Jean-Christophe; Benderitter, Marc; Francois, Agnes

    2009-01-01

    Purpose: Rectum radiation damage and fibrosis are often associated with radiation therapy of pelvic tumors. The endothelin (ET) system has been implicated in several fibrotic diseases but never studied in the context of gastrointestinal radiation damage. This study assessed modifications in ET type 1 (ET-1), ET type A receptor (ET A ), and ET type B receptor (ET B ) localization and/or expression in irradiated human rectal tissue and in a rat model of delayed colorectal injury. We also evaluated the therapeutic potential of long-term ET receptor blockade. Methods and Materials: Routine histological studies of sections of healthy and radiation-injured human rectum tissue were done; the sections were also immunostained for ET A and ET B receptors. The rat model involved the delivery of 27 Gy in a single dose to the colons and rectums of the animals. The ET-1/ET A /ET B expression and ET A /ET B localization were studied at 10 weeks postexposure. The abilities of bosentan and atrasentan to protect against delayed rectal injury were also investigated. Results: The immunolocalization of ET A and ET B in healthy human rectums was similar to that in rat rectums. However, strong ET A immunostaining was seen in the presence of human radiation proctitis, and increased ET A mRNA levels were seen in the rat following colorectal irradiation. Immunostaining for ET A was also strongly positive in rats in areas of radiation-induced mucosal ulceration, atypia, and fibroproliferation. However, neither bosentan nor atrasentan prevented radiation damage to the rectum when given long term. The only effect seen for atrasentan was an increased number of sclerotic vessel sections in injured tissues. Conclusions: As the result of the overexpression of ET A , radiation exposure deregulates the endothelin system through an 'ET A profile' in the human and rodent rectum. However, therapeutic interventions involving mixed or specific ET A receptor blockade do not prevent radiation damage

  7. UTILIDAD DE LA GUÍA DIDÁCTICA DE TELEDETECCIÓN Y MEDIO AMBIENTE PARA LA ENSEÑANZA ACTIVA DE LA GEOGRAFÍA

    Directory of Open Access Journals (Sweden)

    Javier Martínez-Vega

    Full Text Available RESUMEN:La guía está concebida como un atlas en el que se ha compilado una abundante colección de imágenes de la Tierra y de los océanos, adquiridas desde distintos satélites, plataformas espaciales tripuladas y desde la Estación Espacial Internacional. Ilustran distintos fenómenos y riesgos naturales y diferentes impactos provocados por el hombre sobre los recursos naturales. En resumen, se trata de un recurso didáctico para la enseñanza activa de la Geografía, y de otras ciencias afines, en Secundaria y Bachillerato. También se comentan las razones que dificultan el empleo de este tipo de recursos audiovisuales en las aulas.PALABRAS CLAVE: Teledetección, observación de la Tierra, Medio Ambiente, enseñanza activa de la Geografía. ABSTRACT: The guide is elaborated as an atlas in which there has been compiled a rich collection of images of the Earth and oceans, acquired from several satellites, from spatial crewed platforms and from the International Space Station. They illustrate several geographic features, natural irks and various man-made impacts on natural resources. In short, it is a didactic tool to be used for active education of Geography and other related sciences in Secondary and High School. It is also indicated the reasons that interfere the availability of this type of audiovisual resources in the classrooms. KEY WORDS: Remote Sensing, Earth Observation, Environment, active teaching of Geography. RÉSUMÉ: Le guide est conçu comme un atlas qui a compilé une riche collection d'images de la Terre et les océans, acquis auprès de différents satellites, habités plates-formes spatiales et de la Station Spatiale Internationale. Images illustrent les différents phénomènes géographiques et les différents risques naturels et les impacts humains sur les ressources naturelles. En bref, il s'agit d'une ressource éducative pour une pédagogie active de la Géographie, et d'autres sciences connexes dans les

  8. Study on the Therapeutic Effect of Dispersive He-Ne Laser on Radiation Proctitis%弥散型He-Ne激光治疗放射性直肠炎的临床研究

    Institute of Scientific and Technical Information of China (English)

    吴先哲; 宋奇; 邢国良

    2012-01-01

    目的 探讨弥散型He-Ne激光直肠内照射对放射性直肠炎的临床治疗作用.方法 将功率为30 mW、能量密度为3.62 J/cm2弥散型He-Ne激光导入直肠,使He-Ne激光直接照射直肠病变黏膜,观察患者直肠出血、直肠疼痛、腹泻等,比较治疗前后患者直肠黏膜病理组织学的改变.结果 He-Ne激光可以显著减少放射性直肠炎患者的直肠出血,对直肠疼痛、腹泻等症状的影响不大,能明显减轻黏膜组织的炎症反应,并能促进黏膜的修复.结论 弥散性He-Ne激光直肠腔内照射对放射性直肠炎所致的直肠出血有较好的治疗作用.%Objective To study the therapeutic effect of dispersive He-Ne laser on radiation proctitis. Methods Sent He-Ne laser to the rectum, irradiated the mucoga lesions of the rectum with He-Ne laser, observed the major therapeutic effects of He-Ne laser, including but not limited to rectal bleeding and pain, and diarrhea, and compared the histopathological changes of the rectum mncosa before and after the treatment. Results For radiation proctitis patients, He-Ne laser can significantly reduce significantly rectal bleeding .reduce the and inflammatory reaction of mucosal tissue inflammatory reaction, and as well as can facilitate mucosal tissue repair, but has little effect in relieving other symptoms, such as pain and diarrhea. Conclusions The laser irradiation in the rectal cavity with dispersive He-Ne is effective in treating the bleeding caused by radiation proctitis.

  9. Análisis de las metodologías activas en el grado de maestro en educación infantil: la perspectiva del alumnado

    Directory of Open Access Journals (Sweden)

    Mónica VALLEJO RUIZ

    2011-01-01

    Full Text Available Desde el modelo actual de enseñanza basado en las competencias, se plantea la necesidad de un cambio metodológico en las aulas y, como consecuencia de ello, un cambio de roles docentes y discentes. Atendiendo a esta última cuestión, presentamos un estudio con el objeto de deliberar sobre las funciones emergentes del profesorado, que ha pasado de ser un informante clave a convertirse en un mediador y facilitador del aprendizaje. Completando este planteamiento teórico sobre la nueva realidad docente, ofrecemos datos extraídos de alumnos pertenecientes al primer curso del Grado de Maestro en Educación Infantil de la Universidad de Murcia, precisamente por haber sido ésta una de las titulaciones pioneras en la adaptación de los títulos al EEES. A partir de estos datos, centramos nuestra atención en el análisis específico de la utilización de las metodologías activas en el ámbito de la educación superior, ofreciendo la valoración de los estudiantes universitarios sobre el uso que, de tales metodologías, se lleva a cabo durante el proceso de enseñanza-aprendizaje.

  10. ¿Una participación activa del alumno pronostica una buena nota en el examen? (Does the active participation of students serve as a predictor of good marks achievement?

    Directory of Open Access Journals (Sweden)

    José Angel Miguel-Dávila

    2012-11-01

    Full Text Available La metodología del Espacio Europeo de Educación Superior implica un cambio en la forma tradicional de participación de profesor y alumno, incentivando la participación activa del alumno en su proceso de aprendizaje, en detrimento del protagonismo que hasta la actualidad tenía el profesor.En el presente trabajo se presenta el desarrollo y los resultados de un experimento que se ha realizado en la asignatura de Dirección de Operaciones, con el fin de encontrar una relación entre la participación activa del alumno a lo largo del curso (a través de varias tareas solicitadas por el profesor y la calificación obtenida en el examen. Los resultados obtenidos a través del contraste de las hipótesis con técnicas estadísticas de modelos ordered logit, han arrojado que: en términos generales, la participación activa del alumno influye en obtener una mejor calificación obtenida en los exámenes; y de manera más específica, las variables de participación activa que más influyen en la nota del examen son la asistencia y participación diaria y un buen trabajo. Es decir, los alumnos que han estado activos e implicados con la asignatura, les ha servido para preparar mejor el examen y ello se ha visto reflejado en una mejor calificación.De esta manera, se pueden utilizar estos resultados para poder justificar e incentivar a los alumnos de los próximos años a que periódicamente realicen las tareas solicitadas por el profesor, pues ello conllevará un mayor porcentaje de aprobados en los exámenes.

  11. Effect of a prostaglandin - given rectally for prevention of radiation-induced acute proctitis - on late rectal toxicity. Results of phase III randomized, placebo-controlled, double-blind study

    International Nuclear Information System (INIS)

    Kertesz, Tereza; Herrmann, Markus K.A.; Christiansen, Hans; Hermann, Robert M.; Hess, Clemens F.; Hille, Andrea; Zapf, Antonia; Pradier, Olivier; Schmidberger, Heinz

    2009-01-01

    Background and purpose: to assess the late effect of a prostaglandin, given rectally during irradiation, on late rectal toxicity. In the acute treatment setting no significant differences in reducing the incidence of acute proctitis symptoms in patients receiving misoprostol, however, significantly more rectal bleeding had been reported. Patients and methods: a total of 100 patients who had undergone radiotherapy for prostate cancer had been entered into this phase III randomized, placebo-controlled, double-blind study with misoprostol or placebo suppositories. The toxicity was evaluated yearly after cessation of irradiation by the RTOG/LENT-SOMA scale. Results: the median follow-up was 50 months. 20 patients suffered from grade 1, four patients from grade 2 as well, and three patients only from grade 2 toxicity. Frequency, bleeding and urgency were the most commonly reported symptoms. In keeping with other studies and clinical experience, the symptoms peaked within the first 2 years with a median for grade 1 of 13 months and for grade 2 of 15 months. The presence of acute toxicity grade 2 showed a correlation with the development of any late toxicity (p = 0.03). Any acute rectal bleeding was significant correlated with any late rectal bleeding (p = 0.017). Conclusion: misoprostol given as once-daily suppository for prevention of acute radiation-induced proctitis does neither influence the incidence and severity of radiation-induced acute nor late rectal toxicity. Misoprostol has no negative impact on the incidence and severity of late rectal bleeding, in contrast to acute rectal bleeding. The routine clinical use of misoprostol suppositories cannot be recommended. (orig.)

  12. Effect of a prostaglandin - given rectally for prevention of radiation-induced acute proctitis - on late rectal toxicity. Results of phase III randomized, placebo-controlled, double-blind study

    Energy Technology Data Exchange (ETDEWEB)

    Kertesz, Tereza; Herrmann, Markus K.A.; Christiansen, Hans; Hermann, Robert M.; Hess, Clemens F.; Hille, Andrea [Dept. of Radiotherapy and Radiooncology, Univ. of Goettingen (Germany); Zapf, Antonia [Dept. of Medical Statistics, Univ. of Goettingen (Germany); Pradier, Olivier [Dept. of Radiotherapy and Radiooncology, Univ. of Brest (France); Schmidberger, Heinz [Dept. of Radiotherapy and Radiooncology, Univ. of Mainz (Germany)

    2009-09-15

    Background and purpose: to assess the late effect of a prostaglandin, given rectally during irradiation, on late rectal toxicity. In the acute treatment setting no significant differences in reducing the incidence of acute proctitis symptoms in patients receiving misoprostol, however, significantly more rectal bleeding had been reported. Patients and methods: a total of 100 patients who had undergone radiotherapy for prostate cancer had been entered into this phase III randomized, placebo-controlled, double-blind study with misoprostol or placebo suppositories. The toxicity was evaluated yearly after cessation of irradiation by the RTOG/LENT-SOMA scale. Results: the median follow-up was 50 months. 20 patients suffered from grade 1, four patients from grade 2 as well, and three patients only from grade 2 toxicity. Frequency, bleeding and urgency were the most commonly reported symptoms. In keeping with other studies and clinical experience, the symptoms peaked within the first 2 years with a median for grade 1 of 13 months and for grade 2 of 15 months. The presence of acute toxicity grade 2 showed a correlation with the development of any late toxicity (p = 0.03). Any acute rectal bleeding was significant correlated with any late rectal bleeding (p = 0.017). Conclusion: misoprostol given as once-daily suppository for prevention of acute radiation-induced proctitis does neither influence the incidence and severity of radiation-induced acute nor late rectal toxicity. Misoprostol has no negative impact on the incidence and severity of late rectal bleeding, in contrast to acute rectal bleeding. The routine clinical use of misoprostol suppositories cannot be recommended. (orig.)

  13. Análisis de impacto de metodología activa y aprendizaje heurístico en asignaturas de ingeniería

    Directory of Open Access Journals (Sweden)

    Compillay Briones, Servando

    2015-05-01

    Full Text Available Este artículo presenta las experiencias de incorporar metodologías activas y aprendizaje heurístico en asignaturas de primeros años de las carreras de la Facultad de Ingeniería de la Universidad de Atacama, el pilotaje fue realizado con los grupos de alumnos que durante los periodos académicos comprendidos entre marzo 2012 a diciembre 2014, cursaron la asignatura de “Introducción a la Programación”. Para ello se han introducido en estos cursos una serie de técnicas, que sin ser nuevas algunas de ellas, por lo general no se utilizan en asignaturas con grandes cantidades de alumnos o en la formación inicial de los ingenieros noveles. Aun cuando inicialmente las intervenciones realizadas contaron con cierto nivel de rechazo, tanto de profesores como de estudiantes, una vez que ambos logran asumir sus respectivos roles, se comienzan a obtener resultados positivos. Los resultados obtenidos evidencian una mayor asistencia y participación en clases por parte del alumnado, asociado a un considerable incremento en los rendimientos (177% junto con una mejora de los aprendizajes significativos logrados por los estudiantes, especialmente en lo referente a la enseñanza de la lógica en la programación y al desarrollo del pensamiento algorítmico, que históricamente son las dos temáticas que presentaban mayor complejidad en su aprendizaje. El trabajo presentado en este artículo se enmarca dentro del desarrollo del proyecto de investigación interna DIUDA-22249, financiada por la Dirección de Investigación y Postgrado de la Universidad de Atacama

  14. ANÁLISIS DE IMPACTO DE METODOLOGÍA ACTIVA Y APRENDIZAJE HEURÍSTICO EN ASIGNATURAS DE INGENIERÍA

    Directory of Open Access Journals (Sweden)

    Servando Campillay Briones

    2015-01-01

    Full Text Available Este artículo presenta las experiencias de incorporar metodologías activas y aprendizaje heurístico en asignaturas de primeros años de las carreras de la Facultad de Ingeniería de la Universidad de Atacama, el pilotaje fue realizado con los grupos de alumnos que durante los periodos académicos comprendidos entre marzo 2012 a diciembre 2014, cursaron la asignatura de “Introducción a la Programación”. Para ello se han introducido en estos cursos una serie de técnicas, que sin ser nuevas algunas de ellas, por lo general no se utilizan en asignaturas con grandes cantidades de alumnos o en la formación inicial de los ingenieros noveles. Aun cuando inicialmente las intervenciones realizadas contaron con cierto nivel de rechazo, tanto de profesores como de estudiantes, una vez que ambos logran asumir sus respectivos roles, se comienzan a obtener resultados positivos. Los resultados obtenidos evidencian una mayor asistencia y participación en clases por parte del alumnado, asociado a un considerable incremento en los rendimientos (177% junto con una mejora de los aprendizajes significativos logrados por los estudiantes, especialmente en lo referente a la enseñanza de la lógica en la programación y al desarrollo del pensamiento algorítmico, que histórica mente son las dos temáticas que presentaban mayor complejidad en su aprendizaje. El trabajo presentado en este artículo se enmarca dentro del desarrollo del proyecto de investigación interna DIUDA-22249, financiada por la Dirección de Investigación y Postgrado de la Universidad de Atacama.

  15. Medidas activas vs. acciones encubiertas

    Directory of Open Access Journals (Sweden)

    Guiomar Vega

    2015-01-01

    Full Text Available Dossier Desinformación. En 1986, se publica La KGB Hoy: Una Mano Oculta, editada por Random House, tiene 502 páginas y se parece a una "novela de misterio" con pasajes de aventura, suspenso y acción. Su autor, John Barron, reconstruyó la vida del disidente soviético, Comandante Stanislav Aleksandrovich Levchenko, quien permaneció cinco años en Japón en el centro de grandes operaciones de la KGB

  16. Fachadas ventiladas activas para reducir la demanda de calefacción en los edificios de oficinas. El caso de España

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    Irulegi, O.

    2012-12-01

    Full Text Available This paper analyses the energy efficiency of a Ventilated Active Façade –VAF– applied to office buildings in Spain to reduce heating demand. This façade system consists of an outer layer element of 2 mm galvanized steel panels and a 3 cm air cavity where the ventilation air is preheated in winter and exhausted in summer. After defining 8 typical office typologies in Spain, 192 study cases are obtained where different parameters like the percentage of glass in façade, the orientation and the climatic zone of the buildings are considered. The energy demand of all these study cases is obtained using the official simulation tool of the Spanish Technical Building Regulation – CTE called LIDER. The results, in terms of reduction of heating demand, are presented in comparison with the minimum energetic requirements of CTE.

    En este artículo se analiza la eficiencia energética de una Fachada Ventilada ActivaFVA– aplicada a edificios de oficinas en España para reducir la demanda de calefacción. El sistema de fachada consiste en una hoja exterior de 2 mm de acero galvanizado y una cavidad de 3 cm donde el aire de ventilación es precalentado en invierno y extraído en verano. Tras definir 8 tipologías típicas, se han obtenido 192 casos de estudio en los que se consideran diferentes parámetros: la superficie acristalada, la orientación y la zona climática. El cálculo de la demanda energética de los casos de estudio ha sido llevado a cabo mediante el programa LIDER, el método general del Código Técnico de la Edificación – CTE. Los resultados obtenidos en términos de reducción de la demanda de calefacción, se muestran comparados con los mínimos requerimientos exigidos en el CTE.

  17. Pesquisa activa de pacientes con síntomas respiratorios en el Policlínico Municipal Active screening in patients with breathing symptoms in the Municipal Polyclinic

    Directory of Open Access Journals (Sweden)

    Isabel M Pérez Pérez

    Full Text Available Se realizó una investigación descriptiva y transversal que consistió en una pesquisa activa en 710 pacientes con síntomas respiratorios, pertenecientes al área de salud "Municipal" de Santiago de Cuba durante el año 2006. Se constituyó un equipo multidisciplinario de la Unidad Municipal de Higiene y Epidemiología y del área de salud, el cual trabajó en 210 viviendas seleccionadas por tener antecedentes de tuberculosis. Los principales factores de riesgo identificados para contraer la enfermedad fueron: el hábito de fumar, la edad mayor de 65 años y el alcoholismo, además de las condiciones socioeconómicas desfavorables y el hacinamiento. Setenta personas (9,8 % tenían síntomas respiratorios de más de 14 días y una fue diagnosticada con la afección. Los resultados del área de salud en la vigilancia especializada, previa a la investigación, fueron deficientes. De los pesquisados, 24 % estaban infectados por Micobacterium tuberculosis, según los resultados de la prueba de tuberculina, y de ellos, 9 % fueron hiperérgicos.A descriptive and cross-sectional investigation was carried out which consisted of an active screening in 710 patients with breathing symptoms, belonging to the "Municipal" health area of Santiago de Cuba during the year 2006. A multidisciplinary team of the Municipal Unit of Hygiene and Epidemiology and of the health area was constituted, which worked in 210 houses selected because they had a history of tuberculosis. The main risk factors identified to develop the disease were: the smoking habit, more than 65 years old and alcoholism, besides the unfavorable socioeconomic conditions and overcrowding. Seventy people (9,8% had breathing symptoms of more than 14 days and one was diagnosed with the disorder. The results of the health area in the specialized surveillance, previous to the investigation, were poor. Of the screened patients, 24% were infected by Micobacterium tuberculosis, according to the results of

  18. APRENDIZAJE POR DESCUBRIMIENTO, ENSEÑANZA ACTIVA Y GEOINFORMACIÓN: HACIA UNA DIDÁCTICA DE LA GEOGRAFÍA INNOVADORA

    Directory of Open Access Journals (Sweden)

    Rafael De Miguel González

    Full Text Available RESUMEN:Desde la implantación de la reforma educativa basada en presupuestos constructivistas, se ha ido extendiendo el uso de métodos y estrategias didácticas que facilitan la enseñanza activa. La difusión de la cartografía digital, así como su fácil acceso y uso por profesores y alumnos, ha proporcionado numerosas herramientas para la enseñanza y el aprendizaje de la Geografía, especialmente en educación secundaria, así como para la adquisición de las competencias básicas y de competencias espaciales específicas. El presente artículo tiene como objetivo reflexionar sobre la estrecha relación existente entre aprendizaje autónomo por descubrimiento y el empleo de la geoinformación, esto es, analizar en cómo los recursos basados en las nuevas tecnologías de información geográfica están favoreciendo las estrategias de indagación y el aprendizaje significativo del alumno sobre contenidos geográficos. Finalmente, se detallan una serie de características de este tipo de aprendizaje y se muestran ejemplos y recursos para aprender Geografía de forma innovadora. PALABRAS CLAVE:Innovación educativa, geoinformación, enseñanza activa, aprendizaje por descubrimiento, didáctica de la geografía. ABSTRACT:Since the implementation of educational reform based on constructivism, it has extended the use of methods and instructional strategies that facilitate active learning. The spread of digital mapping has provided many tools for teaching and learning of Geography, especially in secondary education, as well as for the acquisition of basic and specific competencies about space. This article aims to reflect on the close relationship between Inquiry-based learning and the use of geo-information, that is, to analyze how resources based on GIS technologies are favoring better Geography learning processes. Finally, there are exposed a number of features of this type of learning, and provides examples and resources to learn geography

  19. A Multicenter, Randomized Study to Evaluate the Efficacy and Safety of Mesalamine Suppositories 1 g at Bedtime and 500 mg Twice Daily in Patients with Active Mild-to-Moderate Ulcerative Proctitis

    Science.gov (United States)

    2010-01-01

    Abstract Background Ulcerative proctitis (UP) is a prevalent condition associated with increased morbidity and mortality. Topical mesalamine (5-aminosalicylic acid [5-ASA]) inhibits inflammatory processes in UP. Methods We evaluated effects of mesalamine 1-g suppository administered QHS compared with 500-mg suppository administered BID on UP activity (e.g., disease extension/mucosal appearance), remission, onset of response, safety and compliance in 97 patients with UP. A 6-week, randomized, multicenter, parallel-group, noninferiority study was conducted (and published) with Disease Activity Index (DAI) at week 6 as the primary efficacy variable and individual components of DAI at week 6 (i.e., stool frequency, rectal bleeding, mucosal appearance, global assessment) as secondary variables. Unreported outcomes were remission (DAI 70%) after 6 weeks in both groups. Mesalamine was well tolerated. Compliance was >96%. Conclusions Mesalamine 500-mg BID and 1-g QHS suppositories are safe and effective for patients with UP. Most patients reported significant improvement within 3 weeks and UP remission and reduced disease extension after 6 weeks of treatment. Validity of QHS administration was confirmed. PMID:20676771

  20. Processos de enfrentamento do estresse e sintomas depressivos em pacientes portadores de retocolite ulcerativa idiopática Procesos de enfrentamiento del estrés y síntomas depresivos en pacientes portadores de rectocolitis ulcerosa idiopática Stress coping strategies and depressive symptoms among ulcerative colitis patients

    Directory of Open Access Journals (Sweden)

    Ana Lúcia Siqueira Costa

    2006-12-01

    Full Text Available Neste estudo se investigou as formas de enfrentamento do estresse e a presença dos sintomas depressivos em 100 indivíduos portadores de retocolite ulcerativa idiopática (RCUI, usuários do Ambulatório de Doenças Inflamatórias do HCFMUSP, que foram comparados com 100 indivíduos acompanhantes de pacientes de outra unidade da mesma instituição, isentos da doença. A metodologia consistiu de aplicar aos dois grupos o Inventário de Estratégias de Enfrentamento de Folkman e Lazarus e o Inventário de Depressão de Beck. As estratégias de enfrentamento mais utilizadas pelo grupo de doentes foram Suporte Social (47% e Reavaliação Positiva (40%, e no grupo controle ocorreu predomínio da estratégia Reavaliação Positiva (52%. Quanto ao transtorno de humor, 71% dos portadores de RCUI não apresentavam sintomas depressivos (contra 78% do grupo controle, 9% apresentavam disforia (contra 9% do grupo controle e 20% sintomas depressivos (contra 13% do grupo controle.En este estudio se investigó las formas de enfrentamiento del estrés y la presencia de los síntomas depresivos en 100 individuos portadores de rectocolitis ulcerosa idiopática (RCUI, usuarios del Consultorio Externo de Enfermedades Inflamatorias del HCFMUSP, que fueron comparados con 100 individuos acompañantes de pacientes de otra unidad de la misma institución, libres de la enfermedad. A metodología consistió en aplicar a los dos grupos el Inventario de Estrategias de Enfrentamiento de Folkman y Lazarus y el Inventario de Depresión de Beck. Las estrategias de enfrentamiento más utilizadas por el grupo de enfermos fueron Soporte Social (47% y Reevaluación Positiva (40%, y en el grupo control predominó la estrategia Reevaluación Positiva (52%.En cuanto al trastorno del humor, 71% de los portadores de RCUI no presentaron síntomas depresivos (contra el 78% del grupo control, 9% presentaron disforia (contra el 9% del grupo control y el 20% síntomas depresivos (contra el

  1. 'Fit Moms/Mamás Activas' internet-based weight control program with group support to reduce postpartum weight retention in low-income women: study protocol for a randomized controlled trial.

    Science.gov (United States)

    Phelan, Suzanne; Brannen, Anna; Erickson, Karen; Diamond, Molly; Schaffner, Andrew; Muñoz-Christian, Karen; Stewart, Ana; Sanchez, Teresa; Rodriguez, Vanessa C; Ramos, Dalila I; McClure, Linda; Stinson, Caro; Tate, Deborah F

    2015-02-25

    High postpartum weight retention is a strong independent risk factor for lifetime obesity, cardiovascular disease, and type 2 diabetes in women. Interventions to promote postpartum weight loss have met with some success but have been limited by high attrition. Internet-based treatment has the potential to overcome this barrier and reduce postpartum weight retention, but no study has evaluated the effects of an internet-based program to prevent high postpartum weight retention in women. Fit Moms/Mamás Activas targets recruitment of 12 Women, Infants and Children (WIC) Supplemental Nutrition Program clinics with a total of 408 adult (>18 years), postpartum (internet-based weight loss intervention. The intervention includes: monthly face-to-face group sessions; access to a website with weekly lessons, a web diary, instructional videos, and computer-tailored feedback; four weekly text messages; and brief reinforcement from WIC counselors. Participants are assessed at baseline, six months, and 12 months. The primary outcome is weight loss over six and 12 months; secondary outcomes include diet and physical activity behaviors, and psychosocial measures. Fit Moms/Mamás Activas is the first study to empirically examine the effects of an internet-based treatment program, coupled with monthly group contact at the WIC program, designed to prevent sustained postpartum weight retention in low-income women at high risk for weight gain, obesity, and related comorbidities. This trial was registered with Clinicaltrials.gov (identifier: NCT01408147 ) on 29 July 2011.

  2. Evolución de las politícas activas de empleo para imigrantes en españa - doi:10.5020/18061230.2006.p45

    Directory of Open Access Journals (Sweden)

    Francisco Sacristán Romero

    2012-01-01

    Full Text Available El objetivo primordial en este artículo es acercar al lector a la realidad actual de las políticas activas de empleo sobre inmigrantes que están presentes en el ordenamiento jurídico de nuestro país. Para ello, y antes de empezar el análisis como tal del objeto de estudio entiendo que es conveniente situar al lector con unas líneas introductorias sobre el estado de la cuestión y conectarlo posteriormente com unos antecedentes históricos que tienen en cuenta la relación entre la situación económica española desde 1975 hasta nuestros días y las circunstancias de la población inmigrante trabajadora en España. Como idea de arranque es esencial plasmar el principio por el cual el derecho de las personas a la justicia y al bienestar personal, directamente ligados a un trabajo u ocupación digna, pasa por la búsqueda de estos valores en lugares diferentes al de nacimiento. Es algo, por otra parte, que la especie humana ha puesto en práctica desde el comienzo de los tiempos. El lugar de nacimiento de cada uno de nosotros influye de manera poderosa em el destino y posibilidades laborales. Se puede comprender claramente que los que nacen en países ricos y democráticos van a tener una serie de oportunidades diferentes a los que nacen y crecen con sus familias en países pobres o en los que imperan dictaduras. Este panorama global hace que el derecho a la emigración, que en algunos países europeos y especialmente en España por su posición geográfica de puerta de entrada a Europa de la mayor parte de la inmigración africana, de origen magrebí y subsahariana, ha sido una cuestión que sistemáticamente está en los medios de comunicación y en la calle como un debate sin fin, debe aceptarse por unas elementales razones de equidad. En los países de la Unión Europea, los grupos sociales políticamente organizados están poniendo limitaciones a la movilidad de la población inmigrante con el objetivo fundamental de la defensa a

  3. Efectividad de la Medida Pausas Activas en el Control de Lesiones Músculo Esqueléticas en Trabajadores del Área de Producción de la Empresa Tuberías y Geosistemas del Perú. Arequipa, 2016

    OpenAIRE

    Falconí Laos, María Alejandra

    2017-01-01

    El estudio de investigación titulado Efectividad de la Medida Pausas Activas en el control de lesiones músculo esqueléticas en trabajadores del área de producción de la empresa Tuberías y Geosistemas del Perú, se ha realizado en la ciudad de Arequipa y corresponde a una investigación de tipo de campo y de nivel experimental. Tuvo como objetivo principal el determinar la efectividad de las medidas Pausas Activas en los trabajadores del área de producción de la empresa Tuberías y Geosistemas de...

  4. Propuesta de una Metodología activa para la enseñanza de matemáticas y su incidencia en el rendimiento académico de los estudiantes de bachillerato de la Unidad Educativa Mercedes de Jesús Molina

    OpenAIRE

    Salazar Álvarez, Edgar Gualberto

    2016-01-01

    Determinar la incidencia de una propuesta metodológica activa para la enseñanza de matemáticas, en el rendimiento académico de los estudiantes de bachillerato de la Unidad Educativa Mercedes de Jesús Molina, de la ciudad de Riobamba, es el objetivo de este trabajo de investigación. Se utilizó el Método Científico. Se propuso una metodología activa-participativa, que tiene características motivadoras, movilizantes, lúdicas, creativas y democráticas; con las cuales se planifica...

  5. LA EVOLUCIÓN DEL EMPLEO EN CHINA: ENTRE EL DISFRAZ DEL PLENO EMPLEO Y LOS PROBLEMAS DE OFERTA DE TRABAJO PARA LA POBLACIÓN ECONÓMICAMENTE ACTIVA

    OpenAIRE

    Juan González García

    2003-01-01

    En este artículo se analiza la política de empleo en China, particularmente la desarrollada en la última década del siglo XX. Demostramos que, si bien la política de empleo se ha orientado a resolver los problemas de la apertura económica y modernización de las empresas del Estado, los retos que la tasa de crecimiento de la población económicamente activa le formula (PEA) determinarán, en gran medida, el éxito o fracaso de la estrategia de apertura externa pues ésta, desde sus inicios fue con...

  6. Pesquisa activa de hipertensión arterial: Un éxito de la atención primaria de salud Active screening of arterial hypertension: A success of primary health care

    Directory of Open Access Journals (Sweden)

    José Manuel Morales Rigau

    2003-12-01

    Full Text Available Se realizó un análisis de la prevalencia de la hipertensión arterial desde 1995 hasta el año 2000, y se demostró cómo a partir de 1998 mediante una intervención educativa en la comunidad, y a través de una pesquisa activa, desarrollada por los Médicos y Enfermeras de la Familia con una amplia participación comunitaria, la provincia de Matanzas logró incrementar en forma significativa su prevalencia conocida de hipertensión arterial, de 10,2 ´ 100 habitantes mayor de 15 años a 26,3 %. El trabajo muestra los resultados finales de la pesquisa. Al compararla con el resto de las provincias del país se demuestra que Matanzas, logró mayor efectividad en la pesquisa activa orientada por el Programa Nacional de Control de la Hipertensión Arterial, y obtuvo la mayor prevalencia conocida en el paísAn analysis of the prevalence of arterial hypertension from 1995 to 2000 was made and it was proved how from 1998 on, the province of Matanzas achieved a significant increase of its known prevalence of arterial hypertension from 10.2 x 100 inhabitants over 15 to 26.3 % by an educative intervention in the community and through an active screening carried out by family physicians and nurses with a wide community participation. The final results of the screening are shown in this paper. On comparing it with the rest of the country, it was observed that Matanzas attained a higher effectivity in the active screening oriented by the National Program for Arterial Hypertension Control, and the highest prevalence known in the country.

  7. PROMOCIÓN DE UNA EDUCACIÓN ACTIVA DE LA ACTIVIDAD FÍSICA ORIENTADA A LA SALUD EN LAS CLASES DE EDUCACIÓN FÍSICA

    Directory of Open Access Journals (Sweden)

    Iradge Ahrabi-Fard

    2005-01-01

    Full Text Available La actividad física es un componente clave para el óptimo desarrollo físico y saludable del cuerpo. La sustancial reducción de actividad física en niños durante las últimas décadas ha contribuido a un incremento de la obesidad en la niñez y los problemas de salud relacionados. A nivel educativo, se espera que la asignatura de educación física contribuya al crecimiento saludable de los alumnos y desarrolle y promueva estilos de vida físicamente activos. Sin embargo, esta materia tiene difícil el cumplimentar esta expectativa dado el insuficiente tiempo, recursos, entrenamiento profesional y apoyo curricular y administrativo. El presente artículo aborda una nueva perspectiva en la contribución de experiencias durante las clases de educación física basada en el desarrollo de habilidades, el incremento de las capacidades físicas (fitness y el establecimiento de un estilo de vida saludable y activo. Se realizan recomendaciones prácticas para el incremento de los niveles de actividad física en el colegio con mínimas alteraciones del currículo académico. Los autores introducen cuatro conceptos originales: de educación activa, cultura personal de actividad física, conductas apropiadas según el tipo de actividad física, y capacitación del alumno. A partir de estos conceptos, se propone un nuevo rol de los educadores físicos como facilitadores y promotores de una educación activa y de una vida saludable.

  8. Valores de referencia de colinesterasa plasmática con los métodos de Michel, EQM y Monotest en población laboral activa del departamento de Antioquia, Colombia.

    Directory of Open Access Journals (Sweden)

    Jaime Carmona Fonseca

    2003-12-01

    Full Text Available Colombia carece de valores de referencia autóctonos para colinesterasas plasmáticas (EC 3.1.1.8. El objetivo de este trabajo fue establecer valores de referencia para la población laboral activa afiliada al Seguro Social. Se diseñaron estadísticamente dos muestras, epidemiológicamente representativas de las poblaciones laborales activas del Valle de Aburrá y del cercano oriente antioqueño. Se midió la actividad colinesterásica plasmática por tres métodos (Michel, EQM® y Monotest® en 415 personas en Aburrá y 412 en Oriente, con edad entre 18 y 49 años. Los promedios de actividad enzimática son estadísticamente similares por región, tanto con el método de Michel como con EQM (Michel: Aburrá, 1,111, y Oriente, 1,125 deltas de pH/hora; EQM: Aburrá, 2,546, y Oriente, 2,476 U/ml. Con Monotest, la media es estadísticamente mayor en Aburrá que en Oriente (5743 y 5459 U/L; p=0,0117. En las dos regiones y con cada método, los hombres tienen niveles de actividad enzimática estadísticamente mayores que las mujeres. Al estratificar por región y sexo, se comprueba que la edad no ejerce influencia significativa en la actividad colinesterásica plasmática, cualquiera que sea el método químico de medición. Nuestros valores son estadísticamente diferentes de los datos extranjeros: con Michel y Monotest, los niveles nuestros son superiores y con EQM son inferiores. Con base en los hallazgos, su interpretación y sus repercusiones, se piensa que estos valores debieran considerarse con prioridad, frente a los foráneos, para la toma de decisiones clínicas y epidemiológicas en el país.

  9. PROPUESTA DIDÁCTICA SOBRE LA EVOLUCIÓN HISTÓRICA DE LA INMIGRACIÓN EN GALAPAGAR (MADRID EN EL MARCO DE LA ENSEÑANZA ACTIVA PARA ALUMNOS DE EDUCACIÓN SECUNDARIA

    Directory of Open Access Journals (Sweden)

    Luis Alfonso Cruz Naïmi

    2009-12-01

    Full Text Available RESUMEN:La presente propuesta didáctica pretende servir de ejemplo sobre cómo se puede tratar el tema de la interculturalidad y la inmigración desde la perspectiva de la Enseñanza Activa, donde los alumnos, por medio de la investigación y el análisis de distintos documentos provenientes del Archivo Municipal de Galapagar y de otros de carácter estadístico, lleguen a conocer con mayor profundidad la evolución histórica de la inmigración en la localidad de Galapagar (Madrid.PALABRAS-CLAVE: Trabajo en archivos, Inmigración, Galapagar, Censo, Padrón, Enseñanza activa, Aprendizaje por Descubrimiento. ABSTRACT:The actual didactic proposal is ment to be an intercultural and inmigration presentation example, under an active learning focus, where pupils can reach a deeper knowledge of the inmigration historic evolution in Galapagar (a village near Madrid. We have used different resources such as the investigation and analysis of different documents from the Galapagar Municipal Archive and some other statistic documents.KEY-WORDS: Archive work, inmigration, Galapagar, census, electoral register, active learning, learning by doing.RÉSUMÉ:Cette proposition didactique veut servir d'exemple sur la manière dont on peut aborder un sujet tel que les relations entre les différentes cultures ainsi que celui de l'immigration, le tout traité du point de vue de l'Apprentissage Actif, où les étudiants, moyennant la recherche et l'analyse des divers documents provenant des archives municipaux de Galapagar et d'autres documents statistiques, peuvent avoir accès plus en profondeur à l'histoire de l'immigration dans la ville de Galapagar (Madrid.MOTS-CLÉS: Travailler en archives, l'Immigration, Galapagar, le recensement, l'Enseignement actif, l'apprentissage par la découverte.

  10. Elaboración y trabajo con casos y otras metodologías activas. Cuatro experiencias de un grupo de profesores de la Facultad de Educación de Zaragoza

    Directory of Open Access Journals (Sweden)

    Santos OREJUDO HERNÁNDEZ

    2008-01-01

    Full Text Available La formación del profesorado implica un proceso individual de aprendizaje mediado, que dé lugar a un profesional competente y reflexivo. Requiere, además de la incorporación de un corpus de conocimientos, el desarrollo de habilidades y destrezas propias de la profesión. Aprender a "saber hacer", fuera del contexto real, la escuela, no es una tarea fácil para los estudiantes de magisterio. En este artículo presentamos nuestra experiencia en el desarrollo de competencias en la formación inicial del profesorado usando metodologías activas, basadas en el aprendizaje en grupo cooperativo y en el uso de casos, problemas y proyectos. Describimos el proceso que hemos seguido en cuatro asignaturas en las que partiendo del trabajo previo de cada profesor hemos ido desarrollando distintos aspectos metodológicos a partir del trabajo conjunto de profesores implicados en distintos proyectos de innovación docente. Algunos aspectos que han resultado claves en las nuevas y no tan nuevas propuestas metodológicas han sido atender a los requerimientos profesionales que se pretendían desarrollar con las asignaturas, buscar metodologías que acerquen a los estudiantes a la práctica profesional o mejorar la evaluación y convertirla en una herramienta más de aprendizaje.

  11. LAS METODOLOGÍAS ACTIVAS Y EL FORO PRESENCIAL: SU CONTRIBUCIÓN AL DESARROLLO DEL PENSAMIENTO CRÍTICO (ACTIVE LEARNING METHODOLOGIES AND SYNCRONOUS FORUM: ITS CONTRIBUTION TO THE DEVELOPMENT OF CRITICAL THINKING

    Directory of Open Access Journals (Sweden)

    Lira Valdivia Rosa Inés

    2010-04-01

    Full Text Available Resumen:Este artículo pretende concienciar acerca de la importancia de las metodologías activas y del foro presencial. Ambos términos constituyen estrategias metodológicas aptas para promover el desarrollo del pensamiento crítico en el aula. Mediante la utilización de mecanismos participativos, estas metodologías promueven la eficacia de los mensajes y la asertividad de la comunicación de los estudiantes, durante los procesos de diálogo que se preparan para tal efecto en el aula universitaria. Los hallazgos o formas cognitivas y actitudinales han sido sustentados en un estudio investigativo que sistematizó la opinión y la percepción de los estudiantes en relación con la utilización del foro como metodología que propicia el desarrollo del pensamiento crítico.Abstract:This article aims to raise awareness about the importance of active learning methodologies and the synchronic forum. Both concepts are considered appropriate methodologies to facilitate and promote critical thinking in the classroom. By using participatory mechanisms in the university classroom, these methods promote the effectiveness of messages and assertive communication of students during classroom activities. The cognitive and actitudinal findings have been supported in a research study that systematized the perception and opinion of students regarding the use of synchronous forum as a methodology that fosters the development of critical thinking.

  12. EL PROCESO DIDÁCTICO BASADO EN METODOLOGÍAS ACTIVAS Y LOS APRENDIZAJES POR DESTREZAS CON CRITERIO DE DESEMPEÑO DE LOS ESTUDIANTES DE EDUCACIÓN GENERAL BÁSICA DE LA ESCUELA GENERAL RUMIÑAHUI DE LA PARROQUIA MULLIQUINDIL, PROVINCIA DE COTOPAXI EN EL AÑO LECTIVO 2013-2014

    OpenAIRE

    Villacrés Chiliquinga, José Luis

    2016-01-01

    Este trabajo de investigación tiene como propósito analizar la incidencia de las técnicas y metodologías activas dentro del proceso didáctico de los aprendizajes por destrezas con criterios de desempeño de los estudiantes de educación general básica de la escuela “General Rumiñahui” de la parroquia Mulliquindil, provincia de Cotopaxi , en el año lectivo 2013 – 2014, ya que la poca o nula utilización de la técnicas y metodologías activas no garantizan la adquisición de los aprendizajes, este e...

  13. Diseño y validación de un cuestionario que mide la percepción de efectividad del uso de metodologías de participación activa (CEMPA. El caso del Aprendizaje Basado en Proyectos (ABPrj en la docencia de la contabilidad

    Directory of Open Access Journals (Sweden)

    Amalia Carrasco Gallego

    2015-10-01

    Full Text Available Numerosos trabajos llevados a cabo en docencia de la contabilidad, que relacionan metodologías de participación activa con desarrollo de competencias técnicas y no técnicas, utilizan cuestionarios para sustentar los hallazgos obtenidos en los mismos. Sin embargo, no se ha llevado a cabo un proceso de validación de los cuestionarios utilizados que garantice la validez y la fiabilidad de cada uno de los ítems que forman parte de los mismos. El objetivo del trabajo ha sido el diseño y validación de un cuestionario que sirva para medir la efectividad de las metodologías de participación activa, en concreto en Aprendizaje Basado en Proyectos (ABPrj. La muestra utilizada está compuesta por alumnos de Administración y Dirección de Empresas que cursaron Contabilidad Avanzada y Análisis Contable, y el periodo de observación es de cuatro cursos (años académicos. El trabajo examinó la estructura factorial del Cuestionario de Efectividad del Uso de Metodologías de Participación Activa (CEMPA a través de un Análisis Factorial Exploratorio y Confirmatorio. Los resultados obtenidos revelaron que la estructura del cuestionario es válida y adecuada para medir la percepción que tienen los alumnos sobre las habilidades y capacidades adquiridas a través de la metodología de participación activa ABPr

  14. APROXIMACIÓN AL CONCEPTO DE ESCALA EN EL PRIMER CICLO DE EDUCACIÓN PRIMARIA. PRESENTACIÓN DE UN JUEGO PARA SU TRATAMIENTO DESDE LA ENSEÑANZA ACTIVA

    Directory of Open Access Journals (Sweden)

    María Jesús Marrón Gaite

    2012-12-01

    Full Text Available Resumen:El objetivo esencial del presente artículo es presentar un juego didáctico que hemos diseñado para facilitar al alumnado del primer ciclo de Educación Primaria la comprensión del concepto básico de escala, con el objetivo de prepararle cognitivamente para la correcta interpretación, en cursos superiores, de este convencionalismo en planos y mapas. La investigación empírica que del mismo hemos realizado, experimentándolo en centros educativos de la ciudad de Madrid, ha puesto de manifiesto su alto grado de utilidad para la enseñanza-aprendizaje del tema. Su empleo en el aula ha supuesto el tratamiento del mismo desde la enseñanza activa, que concede un papel esencial a la metodología lúdica, y ha permitido la consecución de aprendizajes significativos por parte de los escolares a partir de sus ideas y representaciones conceptuales previas.Palabras clave:Convencionalismos cartográficos, escala, enseñanza activa, metodología lúdica, aprendizaje significativo.Abstract:The main objective of the present paper is to introduce a didactic play designed in order to help the students of early years of primary education the understanding of the concept of scale. The understanding of this concept prepare them to the correct interpretation, in further years, of this conventionalism in plans and maps. Empirical research we have conducted on the effectiveness of this material, testing in schools in the city of Madrid, has shown a high degree of usefulness for teaching and learning the subject. The use of this material in the classroom has been done from active teaching, giving a central role to the ludic methodology, and has allowed the achievement of meaningful learning by the students from their previous ideas and conceptual representations.Key words:Cartographic conventionalisms, scale, active teaching, ludic methodology, meaningful learning.Résumé:Le présent article a comme objectif principal, présenter un jéu didactique que

  15. Sexually transmitted infections associated with vulvovaginal symptoms in adolescents denying sexual activity Infecciones de transmisión sexual asociadas a síntomas vulvovaginales en adolescentes que niegan vida sexual activa

    Directory of Open Access Journals (Sweden)

    Elizabeth Velarde-Jurado

    2003-01-01

    Full Text Available OBJECTIVE: To identify clinical, laboratory and ultrasonographic evidence of a probable sexually transmitted infection associated with vulvovaginal symptoms in adolescents denying sexual activity. MATERIAL AND METHODS: The medical records of female adolescents, aged 10-18 years were reviewed. These women received first-time medical care for vulvovaginitis, between 1995 and 1999 at Hospital Infantil de México Federico Gómez, (Children's Hospital. Comparisons between groups were performed, as appropriate, by the unpaired Student's t-test, the Z test or the chi-square test; statistically significant differences were set at a two-tailed pOBJETIVO: Identificar datos clínicos, de laboratorio y ultrasonográficos que permitan el diagnóstico de una infección de transmisión sexual asociada a síntomas vulvovaginales en las pacientes adolescentes que niegan vida sexual activa. MATERIAL Y MÉTODOS: Se revisaron los expedientes de las adolescentes de 10 a 18 años de edad que requirieron atención médica de primera vez por vulvovaginitis entre 1995 y 1999 en el Hospital Infantil de México Federico Gómez. Las comparaciones entre grupos se llevaron a cabo con la prueba t de Student, la prueba de Z, o la de ji-cuadrada. Se utilizó un valor de p<0.05 para establecer diferencias estadísticamente significativas. Se calcularon razones de momios con intervalos de confianza de 95%. RESULTADOS: De 258 adolescentes, en 53 (20.5% se identificó un microrganismo de transmisión sexual y 52 de ellas negaron tener vida sexual activa. No hubo diferencias estadísticas entre los dos grupos de adolescentes en cuanto a la edad, los años de estudio, el nivel socioeconómico, la maduración sexual y la presencia de menarquia. El dolor abdominal en los cuadrantes inferiores, la coloración anormal de la secreción vaginal, un cultivo urinario positivo y un estudio ultrasonográfico abdominal compatible con enfermedad pélvica inflamatoria estuvieron asociados con

  16. La comunidad se activa en los telecentros.

    OpenAIRE

    Rodas Rodas, Enma Beatriz

    2010-01-01

    La presente investigación pretende contribuir al estudio de la aplicación de las Tecnologías de la Información y las Comunicaciones (TICs) para promover y sustentar un desarrollo humano sostenible en las zonas más desfavorecidas de nuestro país y provincia. Dentro de este amplio contexto de estudio, analizaremos el desarrollo de los Telecentros en los lugares donde ya están funcionando, centrándonos en aquellos cuyo principal objetivo sea contribuir al desarrollo humano de comunidades y colec...

  17. "Las bandas sonoras como base de la audición activa: experiencias educativas para el desarrollo musical infantil" [Music for films as a basis of active listening: educational experiences to child music development

    Directory of Open Access Journals (Sweden)

    María del Valle de Moya Martínez

    2011-01-01

    Full Text Available RESUMEN:La Educación Musical contribuye desde edades tempranas a la adquisición paulatina de aprendizajes en el marco de una acción educativa sistematizada. La música favorece el intercambio comunicativo entre los niños/as, así como el desarrollo de unas funciones psicológicas básicas como la atención, la memoria y la percepción visual y auditiva. En la etapa de Educación Infantil, los niños/as se sienten atraídos por los sonidos, las canciones, el movimiento, las posibilidades expresivas de su cuerpo y los ejercicios rítmicos, por lo que las actividades musicales se encaminan al trabajo de las capacidades expresivas y creativas y al desarrollo del oído musical, la sensibilidad hacia la música y la escucha activa, entre otros. El empleo de audiciones basadas en músicas de películas es un importante recurso didáctico debido, por un lado, al carácter motivador de esta actividad y, por otro lado, a los procesos cognitivos y emocionales que se ponen en marcha, fomentando el desarrollo musical infantil.ABSTRACT:Music Education from an early age contributes to the gradual acquisition of learning in a musical instruction. Music promotes the exchange of communication between children as well as it develops psychological functions such as attention, memory and visual and aural perception. In early childhood education, children enjoy exploring sounds and they are also interested in singing songs and knowing the expressive possibilities of their bodies by means of rhythm exercises. In this way, musical activities are focused on expressive and creative skills development, sensitivity towards music and active listening. The use of auditions from music for films is an important educational resource due not only to the motivating nature of this activity, but also to the cognitive and emotional processes that are reached, promoting the development of music in early ages.

  18. Aplicación de un plan de pausas activas en la jornada laboral del personal administrativo y trabajadores del Área de Salud No.1 Pumapungo de la Coordinación Zonal 6 del Ministerio de Salud Publica en la provincia del Azuay en el año 2014

    OpenAIRE

    Pacheco Sarmiento, Adriana Sofía; Tenorio Altamirano, María Fernanda Fabiola

    2015-01-01

    La investigación se realizó con la finalidad de medir el nivel de morbilidad y alteraciones musculo esqueléticos, para evidenciar que la aplicación de las pausas activas como parte de la jornada laboral del personal del Centro de Salud-Uncovía fueron efectivas, se logró una diferencia después de la aplicación, disminuyendo el nivel de morbilidad. The research was conducted in order to measure the level of morbidity and skeletal muscle disorders, to show that the application of the active b...

  19. Diseño e implementación de un sistema local hospitalario de hemovigilancia activa de injuria pulmonar aguda asociada a transfusión: resultados de la prueba piloto en el servicio de hematología en el instituto nacional de cancerología

    OpenAIRE

    Villarroya Salgado, Natalia Patricia

    2012-01-01

    Introducción: La injuria pulmonar aguda relacionada con la transfusión (TRALI) se constituye en la principal causa de morbimortalidad relacionada con la transfusión reportada a la agencia de alimentos y medicamentos (FDA) y a los diferentes sistemas de hemovigilancia. Métodos: Se diseñó un Sistema de hemovigilancia activa que incluye búsqueda, detección, clasificación y análisis de los efectos no deseados e inesperados de la transfusión sanguínea con el fin de corregir sus causas y preveni...

  20. Comparación del efecto de penicilina versus eritromicina para la prevención de infección neonatal por estreptococo grupo B en portadoras activas luego de rotura prematura de membranas ovulares de pretérmino

    OpenAIRE

    Rojas C,Nevenka; Carvajal,Jorge A

    2014-01-01

    Objetivo: Comparar la incidencia de infección neonatal por estreptococo grupo B (SGB) en portadoras activas de SGB con rotura prematura de membranas ovulares de pretérmino (RPMP) luego de profilaxis con penicilina y eritromicina. Métodos: Pacientes diagnosticadas con RPMP entre el año 2004-2009 fueron tratadas con eritromicina (grupo eritromicina), ampicilina, amoxicilina o amoxiclavulánico (grupo penicilina) o sin antibióticos (grupo control) de acuerdo con los protocolos del Departamento en...

  1. Incidencia de la aplicación de un programa de fútbol en actividades que se basan en el incremento de las unidades motoras activas, utilizando como herramienta un adecuado entrenamiento de la fuerza de tipo neuromuscular en niños de 6-8 años

    OpenAIRE

    Pachon Castañeda, Luis Alberto

    2013-01-01

    El presente trabajo es un macro ciclo de cinco meses que se realizó en la ACADEMIA DE FUTBOL ARNOLDO IGUARAN con niños en edades de los 6 a los 8 años pertenecientes al Municipio de La Villa de San Diego de Ubaté, Colombia; el objetivo principal fue determinar Incidencia de la aplicación de un programa de futbol, en actividades que se basan en el incremento de las unidades motoras activas, utilizando como herramienta un adecuado entrenamiento de la fuerza de tipo neuromuscular, haciendo énfas...

  2. Perforación tardía del ventrículo derecho con electrodo de fijación activa en el septum y estimulación diafragmática como primera manifestación clínica

    Directory of Open Access Journals (Sweden)

    Alberto Negrete, MD

    2012-07-01

    Full Text Available La perforación miocárdica es una complicación infrecuente, relacionada con el implante de marcapasos y cardiodesfibriladores, que puede ocurrir al insertar los electrodos; sin embargo, en relación con la utilización de electrodos de fijación activa, ésta puede suceder después de varios días o semanas del implante. Se describe un caso clínico de un paciente a quien se le implantó un marcapasos bicameral con electrodos de fijación activa evidenciándose una semana más tarde perforación miocárdica por el electrodo ventricular, con estimulación diafragmática como manifestación clínica. Inicialmente no había evidencia radiológica de la perforación y requirió abordaje endovascular para extracción

  3. Study of the active layer at the Spanish Antarctic station “Gabriel de Castilla”, Deception Island, Antarctica; Análisis del estado de la capa activa en el emplazamiento de la base antártica española Gabriel de Castilla, Isla Decepción, Antártida.

    Energy Technology Data Exchange (ETDEWEB)

    Pablo, M.A. de; Molina, A.; Recio, C.; Ramos, M.; Goyanes, G.; Ropero, M.A.

    2017-09-01

    The degradation of permanent frozen ground (permafrost) and the increase in the thickness of the active layer may be caused both by natural processes (such as global climate change) and by anthropic activity, which changes the natural environmental conditions that allow its existence, as has been widely reported to occur in the northern polar and subpolar regions. In the case of Antarctica, some scientific research stations are located in areas with permafrost, such as the Spanish Antarctic station “Gabriel de Castilla” on Deception Island. In the place where the station is located, an important increase in erosion has been observed in recent years, including the excavation of new gullies and the erosion of the coastal cliffs. In order to develop an initial analysis of the possible effects of the station on the permafrost degradation, ground temperature has been monitored since 2012 and the thickness and of the active layer and the temperature, both inside and beneath the station, have also been sporadically measured. Here we show the results and discuss how the station reduces the freezing of the ground during the winter when the station is closed and facilitates the warming of the ground during the living periods of the station in the Antarctic summer. Those initial results and conclusions make necessary to continue the study of the permafrost and the active layer in the station site by systematic monitoring of the ground temperature and the thickness of the active layer. [Spanish] La degradación de los suelos congelados (permafrost) y el aumento de espesor de la capa activa pueden deberse tanto a factores naturales, como antrópicos (edificaciones, carreteras, cimentaciones, etc.) que modifican las condiciones naturales y, por tanto, sus características termo-mecánicas, tal y como ha sido profusamente estudiado en el hemisferio Norte. En el caso de la Antártida, algunas bases se encuentran en zonas de permafrost, como es el caso de la base espa

  4. Tuberculosis activa en una cohorte de reclusos infectados por VIH en una cárcel de la Ciudad de México: características clínicas y epidemiológicas Active tuberculosis in a cohort of HIV-infected inmates in a prison in Mexico City: clinical and epidemiological characteristics

    Directory of Open Access Journals (Sweden)

    Christian Hernández-León

    2012-12-01

    Full Text Available OBJETIVO: Determinar las características clínicas y epidemiológicas de los casos con tuberculosis (TB activa en población de cárceles con VIH, que se ve especialmente afectada por ambas epidemias. La infección por VIH incrementa significativamente la probabilidad del desarrollo de TB. MATERIAL Y MÉTODOS: Se realizó un estudio de cohorte en sujetos infectados por VIH e internados en un reclusorio de la Ciudad de México. RESULTADOS: Se encontraron 172 pacientes con VIH, 28 con TB activa (16.3% - 21 (12.2% con afección pulmonar - con una tasa de incidencia de 7.7 por 100 sujetos/año para TB activa y de 4.7 por 100 sujetos/ año para TB pulmonar. No se encontró drogorresistencia. Dieciocho aislados fueron tipificados por RFLP, con una tasa de transmisión calculada de 11%. CONCLUSIÓN: Se encontró una prevalencia de TB en esta población mil veces superior a la observada en la población general y datos sugerentes de transmisión al interior de la cárcel.OBJECTIVE: To determine the clinical and epidemiological characteristics of prison inmates with active tuberculosis in HIV-positive prison populations. MATERIALS AND METHODS: We conducted a cohort study in HIV-infected subjects in a prison in Mexico City, with the aim of determining clinical and epidemiological characteristics of cases with active TB. RESULTS: We detected 172 HIV infected inmates and TB in 28 of them (16.3% - 21 (12.2 with pulmonary TB - with an incidence rate of 7.7/100 persons/year for active TB and 4.7/100 persons/year for pulmonary TB. No drug resistance was found. Two clusters (4 and 2 subjects were observed after RFLP-typing of 18 isolates, with a transmission rate of 11% by molecular and clinical analysis. CONCLUSIONS: The prevalence of active TB was found to be a thousand times greater than in the general population. Evidence of transmission inside the prison was also found

  5. EBP como metodología activa para la enseñanza del cálculo diferencial. discusión y reflexión sobre algunos problemas de cálculo en las ciencias económicas

    Directory of Open Access Journals (Sweden)

    Azcárate, Carmen

    2006-01-01

    Full Text Available Debido a los cambios que se vienen gestando dentro del sistema de educación superior mundial, el sistema de enseñanza está manifestando modificaciones considerables, obligando al profesor a utilizar una metodología más activa, donde el estudiante se vea en la obligación de una mayor participación y así construir su propio conocimiento. La enseñanza del cálculo diferencial a nivel universitario no es la excepción, en este caso, nosotros apostamos por generar conocimiento en el estudiante frente a la transmisión de conocimiento. Tomando en cuenta la puesta en funcionamiento del nuevo sistema de créditos europeos (ECTS; de manera experimental por el momento y oficial a partir de 2010, cuya columna vertebral del proceso de enseñanza-aprendizaje es el estudiante y no el docente como se viene haciendo. Además, el hecho de que en las universidades latinoamericanas y en particular la venezolana, apuestan en sus programas de cálculo por la resolución de problemas como estrategia didáctica; consideramos que es oportuno apostar por una estrategia dinámica y activa como lo es la enseñanza basada en problemas (EBP. En este sentido, la presente comunicación describe parte de una experiencia de discusión y reflexión llevada a acabo con un grupo de profesores de universidad sobre la enseñanza del cálculo diferencial en carreras de ciencias económicas por el alto valor aplicado e instrumental de las matemáticas en la economía.

  6. Epstein-Barr-virus-associeret lymfom hos en patient med colitis ulcerosa i behandling med azathioprin

    DEFF Research Database (Denmark)

    Kofoed, Kristian; Kiszka-Kanowitz, Marianne; Albrectsen, Jens Mørch

    2008-01-01

    A 28 year-old man with ulcerative colitis treated for 10 years with azathioprine (AZA) returned from Central Asia with fever, swollen lymph glands, hepatosplenomegaly, and pancytopenia. He was tested positive for acute Epstein-Barr virus (EBV) infection. Before the final diagnosis of EBV-associat......A 28 year-old man with ulcerative colitis treated for 10 years with azathioprine (AZA) returned from Central Asia with fever, swollen lymph glands, hepatosplenomegaly, and pancytopenia. He was tested positive for acute Epstein-Barr virus (EBV) infection. Before the final diagnosis of EBV......-associated large B-cell lymphoma was confirmed, he died from multiple organ failure. AZA and 6-mercaptopurine are associated with the development of EBV-positive lymphomas in organ-transplanted patients. This type of lymphoma is a rare complication in inflammatory bowel disease....

  7. Fæcestransplantation som behandling af Clostridium difficile-infektion, colitis ulcerosa og metabolisk syndrom

    DEFF Research Database (Denmark)

    Carstensen, Jeppe West; Hansen, Axel Kornerup

    2014-01-01

    Faecal transplantation as a treatment for Clostridium difficile infection, ulcerative colitis and the metabolic syndrome Faecal transplantation as a therapeutic tool is increasingly reported in the scientific literature. Faecal transplantation is currently becoming a treatment for nosocomial......, refractory infections with C. difficile. Furthermore, faecal transplantation has been suggested as a treatment for ulcerative colitis as well as for the metabolic syndrome. In the accumulated literature faecal transplantations appear to be safe, effective and superior to current treatments. Faecal...... transplantation remains a sparsely investigated treatment, however, especially for other diagnoses than C. difficile infection....

  8. Epstein-Barr-virus-associeret lymfom hos en patient med colitis ulcerosa i behandling med azathioprin

    DEFF Research Database (Denmark)

    Kofoed, Kristian; Kiszka-Kanowitz, Marianne; Albrectsen, Jens Mørch

    2008-01-01

    A 28 year-old man with ulcerative colitis treated for 10 years with azathioprine (AZA) returned from Central Asia with fever, swollen lymph glands, hepatosplenomegaly, and pancytopenia. He was tested positive for acute Epstein-Barr virus (EBV) infection. Before the final diagnosis of EBV...

  9. Epstein-Barr-virus-associeret lymfom hos en patient med colitis ulcerosa i behandling med azathioprin

    DEFF Research Database (Denmark)

    Kofoed, Kristian; Kiszka-Kanowitz, Marianne; Albrectsen, Jens Mørch

    2008-01-01

    A 28 year-old man with ulcerative colitis treated for 10 years with azathioprine (AZA) returned from Central Asia with fever, swollen lymph glands, hepatosplenomegaly, and pancytopenia. He was tested positive for acute Epstein-Barr virus (EBV) infection. Before the final diagnosis of EBV......-associated large B-cell lymphoma was confirmed, he died from multiple organ failure. AZA and 6-mercaptopurine are associated with the development of EBV-positive lymphomas in organ-transplanted patients. This type of lymphoma is a rare complication in inflammatory bowel disease....

  10. Proctitis and rectal stenosis induced by nonsteroidal antiinflammatory suppositories

    NARCIS (Netherlands)

    D'Haens, G.; Breysem, Y.; Rutgeerts, P.; van Besien, B.; Geboes, K.; Ponette, E.; Vantrappen, G.

    1993-01-01

    Anorectal ulceration eventually leading to rectal stenosis was observed in 10 patients who abused analgetic suppositories containing acetylsalicylic acid, acetaminophen, and codeine. Most patients were middle-aged women with a neurotic or psychiatric background. Perianal skin lesions were present in

  11. Lymphogranuloma venereum proctitis: A differential diagnose to inflammatory bowel disease

    DEFF Research Database (Denmark)

    Høie, Sverre; Knudsen, Lene Surland; Gerstoft, Jan

    2011-01-01

    Abstract Objective. Lymphogranuloma venereum (LGV) is a sexually transmitted disease, endemic in tropical and subtropical areas for many years. After 2003 there have been several outbreaks in western countries, especially among HIV-positive men who have sex with men (MSM). An important...

  12. La figura del litisconsorcio activa en los juicios laborales

    Directory of Open Access Journals (Sweden)

    Julio Cesar lvarez

    2005-01-01

    Full Text Available La intención de la investigación es proporcionar una versión sobre las diferencias experimentada en la doctrina nacional, cuando varios trabajadores se presenten como actores ante la jurisdiccional laboral, e intente una demanda en forma conjunta y acumulen sus pretensiones en una sola causa. Esta posición la ha denominado la doctrina “acumulación subjetiva de pretensiones”, lo cual pretende en sentido pragmático, la presentación de varias pretensiones en una sola basado en el principio de economía y celeridad procesal. Sobre el punto en cuestión, la Sala Constitucional, del Tribunal Supremo de Justicia, ha negado tal posibilidad, colisionando con la posición de la Sala Social, que reiteradamente la ha venido admitiendo. Visto así, esta colisión doctrinal, se estima, que con la entrada en vigencia de la Ley Orgánica Procesal del Trabajo (2002, la cual consagra la posibilidad de que se plantee este tipo de demandas acumuladas (Art. 49, se superen las posiciones encontradas en la doctrina.

  13. Tectonica activa y geodinamica en el norte de centroamerica

    Science.gov (United States)

    Alvarez Gomez, Jose Antonio

    The rampant success of quantum theory is the result of applications of the 'new' quantum mechanics of Schrodinger and Heisenberg (1926-7), the Feynman-Schwinger-Tomonaga Quantum Electro-dynamics (1946-51), the electro-weak theory of Salaam, Weinberg, and Glashow (1967-9), and Quantum Chromodynamics (1973-); in fact, this success of 'the' quantum theory has depended on a continuous stream of brilliant and quite disparate mathematical formulations. In this carefully concealed ferment there lie plenty of unresolved difficulties, simply because in churning out fabulously accurate calculational tools there has been no sensible explanation of all that is going on. It is even argued that such an understanding is nothing to do with physics. A long-standing and famous illustration of this is the paradoxical thought-experiment of Einstein, Podolsky and Rosen (1935). Fundamental to all quantum theories, and also their paradoxes, is the location of sub-microscopic objects; or, rather, that the specification of such a location is fraught with mathematical inconsistency. This project encompasses a detailed, critical survey of the tangled history of Position within quantum theories. The first step is to show that, contrary to appearances, canonical quantum mechanics has only a vague notion of locality. After analysing a number of previous attempts at a 'relativistic quantum mechanics', two lines of thought are considered in detail. The first is the work of Wan and students, which is shown to be no real improvement on the iisu.al 'nonrelativistic' theory. The second is based on an idea of Dirac's - using backwards-in-time light-cones as the hypersurface in space-time. There remain considerable difficulties in the way of producing a consistent scheme here. To keep things nicely stirred up, the author then proposes his own approach - an adaptation of Feynman's QED propagators. This new approach is distinguished from Feynman's since the propagator or Green's function is not obtained by Feynman's rule. The type of equation solved is also different: instead of an initial-value problem, a solution that obeys a time-symmetric causality criterion is found for an inhomogeneous partial differential equation with homogeneous boundary conditions. To make the consideration of locality more precise, some results of Fourier transform theory are presented in a form that is directly applicable. Somewhat away from the main thrust of the thesis, there is also an attempt to explain, the manner in which quantum effects disappear as the number of particles increases in such things as experimental realisations of the EPR and de Broglie thought experiments.

  14. Evolução do perfil neuromotor e capacidade funcional de mulheres fisicamente ativas de acordo com a idade cronológica Evolución del perfil neuromotor y la capacidad funcional de mujeres fisicamente activas de acuerdo con la edad cronológica Evolution of neuromotor profile and functional capacity of physically active women according to chronological age

    Directory of Open Access Journals (Sweden)

    Sandra Mahecha Matsudo

    2003-11-01

    Full Text Available FUNDAMENTOS E OBJETIVO: Poucos estudos longitudinais têm sido feitos em mulheres fisicamente ativas para determinar o impacto do envelhecimento na aptidão física e capacidade funcional. O objetivo deste estudo foi comparar a evolução do perfil neuromotor e capacidade funcional de mulheres ativas no período de um ano, de acordo com a idade cronológica. MÉTODOS: A amostra foi composta por 117 mulheres de 50 a 79 anos de idade (: 65 ± 6,6 anos participantes de um programa de exercícios aeróbicos, duas vezes por semana, 50 minutos por sessão durante 5,4 ± 3,0 anos e divididas pela idade em: 50-59 (n: 23; 60-69 (n: 60; 70-79 (n: 34. Os testes neuromotores e de mobilidade incluíram: força muscular dos membros inferiores e superiores, agilidade, flexibilidade do tronco, velocidade de levantar-se da cadeira, equilíbrio estático, velocidade normal de andar e velocidade máxima de andar. Os resultados iniciais e nas duas avaliações seguintes, feitas a intervalos de seis meses, foram comparados usando ANOVA two way, com post-hoc Bonferroni. RESULTADOS: Em um ano não houve nenhuma alteração no desempenho neuromotor; já a velocidade de levantar da cadeira e a velocidade de andar evidenciaram diferenças significativas nos grupos de 50-59 e 60-69 anos, apresentando resultados 10-20% melhores; quanto à velocidade máxima de andar, houve melhora (8% nos grupos de 60 a 79 anos. CONCLUSÃO: A evolução da aptidão física e capacidade funcional teve comportamento similar, em mulheres fisicamente ativas, independentemente da idade cronológica. Essa evolução fortalece a hipótese de um efeito favorável da atividade física regular na promoção da saúde, estratégia fundamental do envelhecimento saudável.FUNDAMENTOS Y OBJETIVO: Pocos estudios longitudinales han sido realizados en mujeres físicamente activas para determinar el impacto del envejecimiento de la aptitud física y la capacidad funcional. El objetivo de este estudio fu

  15. Comportamiento de la toxoplasmosis ocular activa en el Instituto Cubano de Oftalmología "Ramón Pando Ferrer" Behavior of the active ocular toxoplasmosis in patients of the "Ramón Pando Ferrer" Cuban Institute of Ophthalmology

    Directory of Open Access Journals (Sweden)

    Eddy Mesa Hernández

    2011-06-01

    Full Text Available OBJETIVO: Describir los hallazgos patológicos en una serie de pacientes con toxoplasmosis ocular. MÉTODOS: Se realizó un estudio observacional descriptivo de serie de casos, con el propósito de describir el comportamiento de la forma activa de la toxoplasmosis ocular en pacientes atendidos en el Instituto Cubano de Oftalmología "Ramón Pando Ferrer" durante el año 2009. Se examinaron 128 pacientes, a quienes se les efectuó examen oftalmológico completo y de laboratorio. RESULTADOS: La forma de presentación más común fue una retinitis, y el grupo etáreo más afectado fue el de 20 a 29 años, con ligero predominio del sexo femenino. La disminución de la visión y los flotadores fueron los principales síntomas de presentación, y el diagnóstico se realizó en 106 pacientes de forma clínica. La inflamación predominó en la zona I de la retina y dañó principalmente, de manera moderada, la visión de los pacientes en el ojo afectado al momento del diagnóstico. Se instauró tratamiento en 122 de los 128 pacientes y este fue en su mayoría el esquema estándar de pirimetamina, sulfadiazina y prednisona. El 53,1 % de los ojos afectados recuperaron su visión normal, mientras permanecieron con disminución de la visión severa 34 ojos, la mayoría causada por complicaciones como cicatrices maculares, que fueron las más registradas. CONCLUSIONES: Buenos resultados visuales pueden ser obtenidos con una terapia adecuada aunque esta dependerá del área de la retina afectada, el nivel de la inflamación intraocular y el tiempo de duración de la enfermedad.OBJECTIVE: To describe the pathological findings in a series of patients diagnosed with ocular toxoplasmosis. METHODS: A case-series, descriptive and observational study was conducted to describe the behavior of the active way of the ocular toxoplasmosis in patients seen in the "Ramón Pando Ferrer" Cuban Institute of Ophthalmology over 2009. A total of 128 were examined who underwent a

  16. LA CONSIDERACIÓN DEL SUJETO DE INVESTIGACIÓN COMO PARTE ACTIVA EN LA EMPRESA FARMACÉUTICA A CONSIDERAÇÃO DO SUJEITO DE PESQUISA COMO PARTE ATIVA NA EMPRESA FARMACÊUTICA THE CONSIDERATION OF THE SUBJECT PARTICIPANT IN RESEARCH AS ACTIVE PART IN THE PHARMACEUTICAL BUSINESS

    Directory of Open Access Journals (Sweden)

    María de la Luz Casas Martínez

    2005-01-01

    Full Text Available Aunque desde hace treinta años se diseñan estrategias internacionales para la protección del sujeto de investigación, la consideración del paciente como parte activa en la empresa farmacéutica es minimizada en la práctica. Una de estas estrategias se encuentra en la Declaración de Helsinki VI, donde el laboratorio se compromete a continuar suministrando posprotocolo el medicamento y/o procedimiento que haya sido benéfico para el paciente participante en el estudio; en la práctica, sin embargo, predomina el incumplimiento de dicho compromiso. La bioética, como disciplina dialógica, trata de acercar a los involucrados buscando lenguajes y puntos comunes para llegar a acuerdos. El presente trabajo expone los argumentos propios de las industrias farmacéuticas, del derecho mercantil y de la ética generalEmbora já fazem 30 anos que se desenharam estratégias internacionais para a proteção do sujeito da pesquisa, a consideração do paciente como parte ativa na empresa farmacêutica é na prática ainda desconsidero. Uma destas estratégias se encontra na Declaração de Helsinque VI, onde o laboratório se compromete a continuar administrando após o encerramento da pesquisa, o medicamento e/ou procedimento que tenha sido benéfico para o paciente participante do estudo. Na prática, ocorre o descumprimento do dito compromisso. A bioética, como disciplina dialógica, trata de abordar todos os elementos envolvidos, buscando linguagem e pontos comuns para chegar a possíveis acordos. O presente trabalho expõe os argumentos próprios das industrias farmacêuticas, o direito mercantil e a ética em geralAlthough for thirty years researchers involved in biomedical investigation have designed international strategies for the protection of the subject of investigation, the consideration of the patient as an active subject in the pharmaceutical business in practice is minimized. One of these compromises in the patient's protection is

  17. Effects of distinct physical activity and meditation programs on quality of life and depression levels in active elderly women Efectos de distintos tipos de actividad física y programas de meditación sobre la calidad de vida y los niveles de depresión en mujeres ancianas activas

    Directory of Open Access Journals (Sweden)

    M. A. Ferreira

    2010-09-01

    Full Text Available

     

    Sedentary aging can evolve to depression which interferes both qualitatively and quantitatively on elderly’s quality of life. The present study compared quality of life and depression levels between sedentary and active elderly women. For this, a correlational ex post facto study was employed, the sample was divided in four groups: dance group (DG, n=23; age=70.79±6.36 years-old; weight training group; meditation group and control group. The protocols used in evaluations were World Health Organization Quality of Life Group-old questionnaire (quality of life and Beck Depression Inventory (depression. In multiple comparisons the results found were satisfying (p<0.05 in dom2, dom3, QVG, dom1 and dom4 variables. Depression also revealed satisfying results: DGxCG (IC=-48.00,-8.86, WGxCG (IC=-53.55,-7.95 and MGxCG (IC=-61.71,-16.11. These results indicate that exercise programs have provoked satisfying results, contributing to better quality of life and depression levels when compared to those presented by the sedentary elderly women.
    Key Words:quality of life; depression; weight training; meditation and dance.

    Envejecer de manera sedentaria puede evolucionar hacia una depresión afectándose la calidad de vida de las personas mayores. El presente estudio comparó la calidad de vida y los niveles de depresión entre ancianas sedentarias y activas. Para esto, un estudio ex post facto fue aplicado, la muestra fue dividida en cuatro grupos: grupo de danza o aerobic; grupo de entrenamiento de musculación o con resistencias; grupo de meditación  y grupo control. Los protocolos empleados en las evaluaciones fueron el cuestionario de calidad de vida “World Health Organization Quality of Life Group-old” y el de determinación de depresión denominado “Beck Depression Inventory”. En comparaciones múltiples los resultados fueron satisfactorios (p<0.05 en

  18. Algunas especificidades sobre la mortalidad asociada a la hemorragia por enfermedad ulcerosa péptica gastroduodenal

    Directory of Open Access Journals (Sweden)

    Lucas García Orozco

    2015-05-01

    Full Text Available En la actualidad constituye un verdadero problema científico la diversidad de criterios sobre las características epidemiológicas, clínicas y quirúrgicas de la hemorragia digestiva alta no varicosa, debido a sus altas tasas de letalidad y mortalidad, por cuanto resulta de gran importancia identificar los factores pronósticos de complicaciones y decesos, inherentes a esta entidad clínica, a fin de elaborar un protocolo de actuación y buenas prácticas, una vez reconocidas las condiciones modificables que disminuyan el número de fallecimientos por esta causa, sobre todo en la población envejecida como grupo vulnerable, de donde se derivaría la trascendencia de su impacto médico social. Todo ello justifica la necesidad de profundizar en los principales aspectos cognoscitivos relacionados con este tema, puesto que solo contando con equipos de trabajo altamente especializados, podrá elevarse la calidad asistencial y, con esa premisa, el índice de supervivencia de quienes presenten ese tipo de sangrado por enfermedad ácido péptica

  19. Competency-based curriculum and active methodology: perceptions of nursing students Currículo por competencia y metodología activa: percepción de estudantes de enfermería Currículo por competência e metodologia ativa: percepção de estudantes de enfermagem

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    Vania Daniele Paranhos

    2010-02-01

    Full Text Available This study identifies the perceptions of undergraduate students at the University of São Paulo at Ribeirão Preto, Brazil, College of Nursing (EERP-USP concerning the teaching-learning process in two courses: “Integrated Seminar: Health-Disease/Care Process in Health Services Policies and Organization”, which was offered to first-year students in 2005 and 2006 and “Integrality in Health Care I and II”, which was offered to second-year students in 2006. The courses’ proposal was to adopt active methodology and competency-based curriculum. Data were collected from written tests submitted to 62 students at the end of the curse, focusing on the tests’ pertinence, development of performance, structure and pedagogical dynamics, organization and settings. Thematic analysis indicated that students enjoyed the courses, highlighted the role of the professor/facilitator at points of the pedagogical cycle and learning recorded in students’ portfolios. Students valued their experience in the Primary Health Care setting, which was based on, and has since the beginning of the program been based on, the theory-professional practice interlocution and closeness to the principles of the Unified Health System (SUS.Se tuvo por objetivo identificar la percepción de los estudiantes de bachillerato en la EERP/USP, sobre el proceso de enseñanza-aprendizaje, en las disciplinas Seminario Integrado: Proceso Salud-Enfermedad/Cuidado en la Política y Organización de los Servicios de Salud, del primer año, en 2005 y 2006, e Integralidad en el Cuidado en Salud I y II, del segundo año, en 2006, cuya propuesta era adoptar metodología activa y currículo integrado, orientado por competencia. Se utilizó, en la recolección de datos, evaluaciones escritas instituidas, realizadas por 62 estudiantes al final de esas disciplinas, focalizando su pertinencia, desarrollo de desempeños, estructura y dinámica pedagógica, organización y escenarios. Del an

  20. “Elaboración e implementación de una guía didáctica “ el motor del saber“ en base a técnicas activas de aprendizaje para fortalecer el proceso de enseñanza aprendizaje de octavo a décimo año en la asignatura de ciencias naturales de la escuela de educación básica " Tnte. Crnel. John merino b." El Tablón, del cantón Colta en el año lectivo 2013 - 2014”

    OpenAIRE

    Paguay Cacuango, Verónica Isabel

    2015-01-01

    De acuerdo al análisis realizado a los estudiantes verifiqué que tienen dificultad de aprendizaje porque no desarrollar la creatividad, criticidad, el razonamiento en Ciencias Naturales, por tal razón he sentido la necesidad de la “Elaboración e Implementación de una Guía Didáctica El Motor del Saber en base a Técnicas Activas de aprendizaje para fortalecer el proceso de enseñanza aprendizaje de octavo a décimo año en la asignatura de Ciencias Naturales de la Escuela de Educación Básica Tnt...

  1. Arco de Charles Maguerez: refletindo estratégias de metodologia ativa na formação de profissionais de saúde El Arco de Charles Maguerez: una reflexión sobre las estrategias de metodología activa para la formación de los profesionales del área de la salud Charles Maguerez Arc: reflecting methodology strategies on active training for health professionals

    Directory of Open Access Journals (Sweden)

    Marta Lenise do Prado

    2012-03-01

    Full Text Available A educação superior na área da saúde vem passando por profundas mudanças para acompanhar as correntes de pensamento que norteiam a formação do profissional e do docente. Novas tendências pedagógicas apontam a necessidade da formação de um profissional crítico-reflexivo, capaz de transformar sua realidade social. Este artigo trata-se de um relato de experiência que teve por objetivo apresentar as vivências no desenvolvimento de um seminário durante uma disciplina do mestrado, no curso de Pós-Graduação em Enfermagem, ao abordar o tema Metodologia Ativa como a Problematização e a Aprendizagem Baseada em Problemas, por meio da utilização do Arco de Charles Maguerez, seguindo as etapas de observação da realidade, pontos-chave, teorização, hipótese de solução e aplicação na realidade. Essa experiência vivida, a partir da proposta pedagógica, foi significativa e possibilitou aos alunos/docentes repensar e reconstruir suas próprias práticas pedagógicas.La educación superior en el área de la salud está experimentado cambios profundos para seguir las corrientes de pensamiento que orientan la formación del profesional y del docente. Las nuevas tendencias pedagógicas indican la necesidad de .This formación de un profesional crítico y reflexivo, capaz de transformar su realidad social. Este artículo es un relato de experiencia que tiene por objetivo presentar las vivencias en el desarrollo de un seminario para el curso de maestría de Postgrado en Enfermería, al abordar el tema: Metodología activa como Problematización y Aprendizaje Basado en Problemas, mediante el uso del Arco de Charles Maguerez, según las etapas de observación de la realidad, puntos importantes, la teoría, hipótesis de soluciones e implementación en la realidad. La experiencia vivida, según esa propuesta pedagógica, fue importante y permitió a los estudiantes y a los maestros repensar y reconstruir sus propias prácticas pedag

  2. Update on the surgical management of ulcerative colitis and ulcerative proctitis: current controversies and problems.

    Science.gov (United States)

    Sagar, P M; Pemberton, J H

    1995-01-01

    : The surgical management of ulcerative colitis has been revolutionized in recent years by the development of the ileal pouch-anal procedure. Although it is now the operation of choice for most patients, there remain several controversies. A variety of designs of ileal pouch are available each with advantages and disadvantages. The technique used to anastomose the pouch to the anal canal is also open to debate with some surgeons favoring distal mucosectomy with eradication of all disease and others choosing to perform a stapled anastomosis to achieve better functional results. The main concern for gastroenterologists, however, is the risk of development of pouchitis. The etiology, diagnosis, and treatment of this condition will also be discussed in this review as well as the more classical options for the surgical treatment of ulcerative colitis.

  3. Sucralfate does not ameliorate acute radiation proctitis: randomised study and meta-analysis.

    Science.gov (United States)

    Hovdenak, N; Sørbye, H; Dahl, O

    2005-09-01

    During pelvic radiotherapy, many patients develop radiation-induced gastrointestinal symptoms, which may interfere with treatment. Prophylaxis during radiotherapy should ideally prevent acute reaction and the development of delayed injury. Sucralfate, an aluminium sucrose octasulphate, has been used for acute and delayed radiation side-effects. However, conflicting results have been published. We report here a prospective, randomised, placebo-controlled study of prophylactic sucralfate during pelvic radiotherapy. In addition, a meta-analysis of available data from the literature has been carried out. Fifty-one patients with localised pelvic tumours scheduled for curative conformal pelvic radiotherapy (total dose 64-70 Gy over 6.5-7 weeks in 2 Gy daily fractions) were included. Peroral sucralfate 2 g three times daily, or identically appearing placebo tablets, was given during the course of radiotherapy. Symptom registration, endoscopy and biopsies were carried out immediately before radiotherapy, 2 weeks and 6 weeks into the treatment course, and 2 weeks after completing radiotherapy. Mucosal cup forceps biopsies were obtained through a rigid proctoscope. Graded endoscopic appearance and quantitative histology were registered. On the basis of previously published negative reports, an unplanned interim analysis of 44 evaluable patients showed significantly increased diarrhoea in the sucralfate group and the trial was stopped. No difference was seen in other symptoms, endoscopic appearance or histology. A meta-analysis comprising five published studies showed no statistically significant beneficial effect of sucralfate on acute symptoms. Sucralfate cannot be recommended for prophylaxis of acute radiation proctopathy and may even worsen the symptoms.

  4. Parks coloanal pull-through anastomosis for severe, complicated radiation proctitis

    Energy Technology Data Exchange (ETDEWEB)

    Gazet, J.C.

    1985-02-01

    A variety of operations have been proposed for the treatment of radiation injuries of the rectum. In this study, the procedure advocated by the late Sir Alan Parks--resection of the diseased segment down to its points of fixation to the vagina, bladder or prostate; with perianal mucosal stripping of the anorectal segment and primary coloanal (pull-through) anastomosis--was performed in 11 patients. In two others, an attempt at colorectal anastomosis was abandoned because of extreme scarring in the pelvis. The procedures were done following definitive treatment of carcinoma of the rectum (seven patients), carcinoma of the cervix (two patients), carcinoma of the uterus (one patient), carcinoma of the ovary (one patient), seminoma (one patient), and carcinoma of the bladder (one patient). One patient died from a pulmonary embolus on the seventh postoperative day. Of the survivors with a coloanal anastomosis, all had successful closure of their temporary colostomies with follow-up from one to six years. In eight, continence was assessed as being good or excellent. Four patients required anastomotic dilation and another required a surgical procedure for anastomotic stricture. There was one instance each of reoperation for small bowel obstruction and ileocolic fistula. There were no instances of recurrence of hemorrhage, fistulas, perineal pain or tenesmus. The Parks procedure obviates the need for a difficult dissection of the lower rectum and separation of tissues damaged by radiation and avoids the need for eversion techniques. Its selective use is advocated for patients suffering from severe radiation injuries of the rectum.

  5. Parks coloanal pull-through anastomosis for severe, complicated radiation proctitis

    International Nuclear Information System (INIS)

    Gazet, J.C.

    1985-01-01

    A variety of operations have been proposed for the treatment of radiation injuries of the rectum. In this study, the procedure advocated by the late Sir Alan Parks--resection of the diseased segment down to its points of fixation to the vagina, bladder or prostate; with perianal mucosal stripping of the anorectal segment and primary coloanal (pull-through) anastomosis--was performed in 11 patients. In two others, an attempt at colorectal anastomosis was abandoned because of extreme scarring in the pelvis. The procedures were done following definitive treatment of carcinoma of the rectum (seven patients), carcinoma of the cervix (two patients), carcinoma of the uterus (one patient), carcinoma of the ovary (one patient), seminoma (one patient), and carcinoma of the bladder (one patient). One patient died from a pulmonary embolus on the seventh postoperative day. Of the survivors with a coloanal anastomosis, all had successful closure of their temporary colostomies with follow-up from one to six years. In eight, continence was assessed as being good or excellent. Four patients required anastomotic dilation and another required a surgical procedure for anastomotic stricture. There was one instance each of reoperation for small bowel obstruction and ileocolic fistula. There were no instances of recurrence of hemorrhage, fistulas, perineal pain or tenesmus. The Parks procedure obviates the need for a difficult dissection of the lower rectum and separation of tissues damaged by radiation and avoids the need for eversion techniques. Its selective use is advocated for patients suffering from severe radiation injuries of the rectum

  6. FísicActiva: applying active learning strategies to a large engineering lecture

    Science.gov (United States)

    Auyuanet, Adriana; Modzelewski, Helena; Loureiro, Silvia; Alessandrini, Daniel; Míguez, Marina

    2018-01-01

    This paper presents and analyses the results obtained by applying Active Learning techniques in overcrowded Physics lectures at the University of the Republic, Uruguay. The course referred to is Physics 1, the first Physics course that all students of the Faculty of Engineering take in their first semester for all the Engineering-related careers. Qualitative and quantitative data corresponding to three semesters are shown and discussed, indicating that the students that attended these lectures outperformed the students that followed the course in the traditional way: the pass rates increased, whereas the failure rates decreased. The students highly valued this methodology, in particular, the interactive and relaxed dynamics, highlighting the concern of professors to answer questions by means of new questions so as to promote reasoning. The results obtained point to a work path that deserves to be deepened and extended to other Engineering courses.

  7. Participación y liderazgo estudiantil: Una apuesta por la ciudadanía activa

    OpenAIRE

    Claudia Santamaría; María Oliva Sánchez

    2011-01-01

    El liderazgo asumido como postura ética con corresponsabilidad hacia la acción plantea un reto complejo en su alcance, por múltiples aspectos inherentes a los seres humanos y sus procesos evolutivos. Es necesario emprender caminos y aventurarse a tejer formas y experiencias que  lleven a este. La Escuela de Enfermería de la Universidad del Valle, interpretando la misión universitaria y basada en su Plan Estratégico 2005-2015; toma como propia la responsabilidad de promover espacios e iniciati...

  8. Valoración de metodologías activas empleadas en estudiantes universitarios

    OpenAIRE

    Morales-Rodríguez, F.M.; Narváez-Peláez, M.A.

    2016-01-01

    El presente trabajo se enmarca en el Proyecto de Innovación Educativa Nuevas metodologías de evaluación formativa de competencias transversales en la docencia práctica, con el apoyo de TIC y campus virtual, en las ramas de conocimiento de Ciencias, Ciencias de la Salud, Ciencias Sociales y Jurídicas y en la docencia de ámbito Internacional (PIE13-031). El objetivo es presentar una evaluación de los métodos de enseñanza/aprendizaje que se consideran más apropiados para el proceso de enseñanza/...

  9. Educación emprendedora y metodologías activas para su fomento

    Directory of Open Access Journals (Sweden)

    Jessica Paños Castro

    2017-01-01

    Full Text Available El emprendimiento no solo se refiere a la creación de nuevas empresas y/o negocios. Hoy en día a su vez es entendida como una competencia que engloba un conjunto de habilidades y destrezas como son la creatividad, el liderazgo, el trabajo en equipo, la innovación, la toma de decisiones…; todas ellas demandadas en el ámbito personal, social y profesional. Las instituciones educativas deberían promover está competencia al verse contemplada en las leyes educativas (Ley 2/2006; Ley 8/2013 y planes de estudios universitarios. Ahora bien, ¿qué metodologías se deberían emplear para desarrollar está competencia?, ¿En qué consisten? y ¿qué competencias fomenta cada una de ellas? El objetivo de este artículo es responder a estos interrogantes realizando una revisión bibliográfica de los últimos artículos publicados, pero antes se hace un recorrido por el término emprendimiento para a continuación señalar las habilidades y destrezas que engloba esta competencia, y el objetivo de la educación emprendedora.

  10. Effects of a promotor-based intervention to promote physical activity: Familias Sanas y Activas.

    Science.gov (United States)

    Ayala, Guadalupe X

    2011-12-01

    This within-participants, single time-series study tested a train-the-trainer, promotor-based physical activity (PA) intervention to improve fitness and health indicators. Thirty unpaid promotores were trained to promote PA through free exercise classes. Measurements of 337 female community participants at baseline, 6 months, and 12 months assessed changes in health indicators, including systolic and diastolic blood pressure, waist circumference, body mass index (defined as weight in kilograms divided by the square of height in meters), aerobic fitness, and hamstring flexibility, as well as self-reported health indicators (PA, depression) and psychosocial factors (barriers, self-efficacy, and social support-all specific to PA). Mixed effects models showed intervention participation improved systolic blood pressure (P ≤ .001), waist circumference (P ≤ .001), fitness (P ≤ .001), and hamstring flexibility (P ≤ .001). We also noted improvements in use of community resources (P ≤ .05), depressed mood and anhedonia (P ≤ .01), perceived barriers to be physically active (P ≤ .05), and community support for PA (P ≤ .001). Self-efficacy decreased (P ≤ .05), and participation dose (i.e., exposure), as measured by attendance at exercise classes, was not associated with observed changes. Promotores can promote PA in their community and achieve meaningful changes in the residents' health.

  11. FísicActiva: Applying Active Learning Strategies to a Large Engineering Lecture

    Science.gov (United States)

    Auyuanet, Adriana; Modzelewski, Helena; Loureiro, Silvia; Alessandrini, Daniel; Míguez, Marina

    2018-01-01

    This paper presents and analyses the results obtained by applying Active Learning techniques in overcrowded Physics lectures at the University of the Republic, Uruguay. The course referred to is Physics 1, the first Physics course that all students of the Faculty of Engineering take in their first semester for all the Engineering-related careers.…

  12. Revisión de conceptos de la encuesta de población activa

    Directory of Open Access Journals (Sweden)

    CRISTINA GARCÍA SÁINZ

    1993-01-01

    Full Text Available Esta nota de investigación versa sobre la necesaria revisión de los indicadores que actualmente se utilizan para medir el trabajo. Las categorías utilizadas en la EPA, tales como "actividad", "inactividad" o "paro", son útiles para dar cuenta de la situación laboral de la población masculina, pero resultan inapropiadas cuando se trata de reflejar la participación de las Mujeres en la actividad económica. En la actualidad, el concepto de trabajo define no sólo la actividad laboral, sino también la no mercantil. Sin embargo, los criterios metodológicos aplicados por los organismos responsables de la recogida y tratamiento de la información socioestadística excluyen la consideración de la actividad no mercantil y sitúan al empleo como el referente de todo trabajo. La escasa representación de las mujeres en el espacio económico requiere el uso de nuevos criterios, indicaciones y formulaciones teóricas que reflejen e interpreten la participación de mujeres y hombres en la actividad económica.

  13. Del "estancamiento estabilizador" hacia una política activa de financiamiento del desarrollo

    OpenAIRE

    Suárez Dávila, Francisco

    2005-01-01

    ¿Por qué no crece la economía mexicana? Una respuesta a ese cuestionamiento atañe a la inoperancia de los principales instrumentos de financiamiento para el desarrollo. Suárez Dávila nos presenta el entorno general de la política financiera mexicana donde a la vez que destaca los avances en la materia en los últimos años, también pone de relieve la ineficacia del sector financiero para captar ahorro y canalizarlo a la inversión productiva, así como la incapacidad fiscal para acrecer el ahorro...

  14. Audiencias activas y periodimos: ¿ciudadanos implicados o consumidores motivados?

    Directory of Open Access Journals (Sweden)

    Pere Masip

    2015-09-01

    lsan a los ciudadanos a participar activamente a través de los mecanismos de participación que los  medios de comunicación ponen a su disposición en sus propias webs o a través de las redes sociales. Así como del rol que los usuarios atribuyen a su implicación en el funcionamiento de los medios y si contribuye a mejorar la función democrática de los medios de comunicación. Este artículo pretende aportar algo de luz en este aspecto.

  15. Perfil de las estudiantes adolescentes sexualmente activas en colegios secundarios de Lima, Perú.

    OpenAIRE

    CHIRINOS, Jesús L.; BRINDIS, Claire D.; SALAZAR, Victor C.; BARDALES, Olga T; REÁTEGUI, Ludmila R.

    2013-01-01

    Objetivo: Identificar el nivel de conocimiento y las actitudes sobre sexualidad y las prácticas sexuales de las estudiantes adolescentes en colegios secundarios de Lima, Perú. Materiales y métodos: fue una encuesta anónima y auto-administrada fue completada por 935 mujeres de 12-19 años como parte de un Modelo de Intervención sobre Educación Sexual en Colegios Secundarios. Las preguntas cubrieron 6 áreas: información socio-demográfica, características de sus familias, actividades personales, ...

  16. Perfil de las estudiantes adolescentes sexualmente activas en colegios secundarios de Lima, Perú

    Directory of Open Access Journals (Sweden)

    Jesús L Chirinos

    1999-04-01

    Full Text Available Objetivo: Identificar el nivel de conocimiento y las actitudes sobre sexualidad y las prácticas sexuales de las estudiantes adolescentes en colegios secundarios de Lima, Perú. Materiales y métodos: fue una encuesta anónima y auto-administrada fue completada por 935 mujeres de 12-19 años como parte de un Modelo de Intervención sobre Educación Sexual en Colegios Secundarios. Las preguntas cubrieron 6 áreas: información socio-demográfica, características de sus familias, actividades personales, actitudes y conocimientos en sexualidad, experiencia sexual y uso de anticonceptivos. Resultados: El nivel de conocimientos de sexualidad fue limitado (media=9.9 al ser medido a través de 20 preguntas básicas. Las mujeres conversaban mas sobre sexualidad con sus madres (43% y con sus pares mujeres (41%. Las actitudes con respecto a la sexualidad y la anticoncepción fueron positivas pero algunas son ambivalentes con respecto al uso de anticonceptivos. El 8% de la muestra ya ha tenido relaciones coitales y la edad del primer coito fue de 14 años. Mientras que el 63% de las estudiantes usaría la píldora, el 74%, también, dió razones para no usarla. La actividad sexual se relacionó a la edad, si repitió de grado, si habla sobre sexualidad con el enamorado o amigo, si sus razones para tener relaciones coitales son "por placer o diversión", si ha tenido enamorado y si ha tenido mas de 2 enamorados. Conclusiones: Las estudiantes adolescentes en esta muestra tienen un conocimiento limitado en sexualidad y anticoncepción, actitudes ambivalentes en el uso de anticonceptivos, aunque ellas estuvieran en riesgo de un embarazo no planeado o de adquirir una ETS. Estos hallazgos señalan la necesidad de modelos de intervención en colegios y comunidades dirigidos a reducir las actitudes ambivalentes y los comportamientos de riesgo entre las adolescentes con un uso consistente y correcto de los anticonceptivos. ( Rev Med Hered 1999; 10:49-61 .

  17. Vita activa in biotechnology: what we do with fungi and what fungi do with us.

    Science.gov (United States)

    Weinhold, Martin; Mast-Gerlach, Edeltraud; Meyer, Vera

    2017-01-01

    Filamentous fungi are fascinating microorganisms. One of the reasons why it is so worthwhile to take a closer look at them is their capacity to produce secondary metabolites. Some of these substances have the potential to be of great use for mankind, such as it was the case with penicillin and its discovery in 1928. Almost a century later, the situation in healthcare could possibly turn back to the state before the development of the first antibiotics. Due to an overuse of antibiotics we are facing a surge of multiresistant bacteria that are not inhibited by any of the currently known drugs. That was part of the background why a European research project was launched in October 2013, titled "Quantitative Biology for Fungal Secondary Metabolite Producers", or "QuantFung". Fifteen young scientists embarked on a new phase in their career, moving to new work environments within Europe and dedicating their work lives intensively to the quest for useful secondary metabolites. After 4 years, the QuantFung project concluded in October this year. In this commentary, we aim to convey what it means to work in this field of fungal biotechnology and how important it is to improve the efficiency of the research therein. We introduce five out of the fifteen fellows at length and let them have their say about the adventure of science, euphoric moments, prospects and doubts. We also raise questions about the current state of research in academia, something the QuantFung fellows experienced first-hand. Being a scientist often goes beyond earning money to make one's living. This is why we also reflect on aspects of the meaning of work in our western society, where production for profit's sake is a main driver. For that we refer to one of the most distinguished thinkers of the twentieth century, to Hannah Arendt.

  18. The "Civic-Minded" Professional? An Exploration through Hannah Arendt's "Vita Activa"

    Science.gov (United States)

    Kreber, Carolin

    2016-01-01

    Recent reform initiatives calling for "civic" ("public-good" or "democratic") professionalism can be seen as a response to the widely reported decline in public trust in the professions and an attempt to partially remedy this problem through a more publically engaged professionalism. The author draws on the political…

  19. ACTIVA 3 PROJECT: 3 HOURS OF PHYSICAL ACTIVITY LESSONS VS 2 HOURS OF PHYSICAL ACTIVITY LESSONS

    Directory of Open Access Journals (Sweden)

    Juan J. Pulido

    2015-04-01

    Full Text Available El Informe de Recomendaciones mundiales sobre Actividad Física (AF para la salud desarrollado por la OMS (Organización Mundial de la Salud, 2010 indica que de un total de 7.125 millones de personas presentan niveles de AF por debajo del mínimo recomendado. Este fenómeno está considerado como una epidemia que se sitúa en el cuarto factor de riesgo de la mortalidad mundial, causando una alarmante obesidad infantil y adolescente. En España, entre el 2005 y el 2010, se demostró que el 35% de los chicos y chicas de entre 9 y 17 años eran sedentarios y el 11% moderadamente sedentarios, y que a partir de los 15 años, la mitad de los adolescentes sólo realizaban AF en las clases de Educación Física (EF. En este sentido, la EF se considera un medio excelente para desarrollar los beneficios y hábitos saludables que ofrece la AF, transmitiendo conocimientos y actitudes positivas en los alumnos hacia la práctica de AF, y con ello la adherencia a estas actividades de forma regular (Ntoumanis & Standage, 2009. De hecho, uno de los principales objetivos a conseguir a través de la asignatura de EF es “dotar a los jóvenes de las habilidades, del conocimiento y de las competencias para participar en actividades físicas en su tiempo libre relacionadas con la salud y el bienestar” (BOE, 05/01/2007. Sin embargo, la carga lectiva destinada a EF no es la misma en todos los países. A pesar de las recomendaciones oficiales del Parlamento Europeo (3 horas semanales de EF, dos acontecimientos claves acontecidos en España pueden constituir a un retroceso a situaciones no deseadas y ya vividas endécadas pasadas. Por un lado, la Ley Orgánica de Educación (LOE, 2006 permitió una disminución de los minutos semanales asignados al área de la EF curricular. En este contexto, los últimos decretos aparecidos en algunas CCAA en referencia a las nuevas asignaciones de mínimos horarios para las diferentes áreas curriculares de primaria y secundaria, no han favorecido a la asignatura de EF, de forma que se ha optado por destinar dos horas de EF a la semana, valores significativamente inferiores a los registrados en otros países. Según los datos aportados por Eurydice (2013, España es uno de los países de Europa que menos horas dedica a la asignatura de EF (3-4% de la carga lectiva total, en contraposición a otros países como Francia que destina el 14% del currículo.Objetivo: Determinar los efectos en los niveles de condición física por una intervención basada en la incorporación de una hora semanal extra de EF, con respecto a los alumnos de un grupo control que mantienen 2 horas semanales.

  20. Una metodología activa para la resolución de problemas

    Directory of Open Access Journals (Sweden)

    Miró-Julià, Margaret

    2006-01-01

    Full Text Available El objetivo de esta ponencia es presentar las conclusiones del proyecto de mejora de la calidad docente titulado “El uso de estrategias adecuadas para la resolución de problemas de Estadística” que se realizó en la Universidad de las Islas Baleares durante el curso 2005-2006. Debido a nuestra dilatada experiencia en la enseñanza de las asignaturas Estadística Económica y Métodos Matemáticos para la Economía I, II y III de los estudios que dependen de la Facultad de Economía, somos conscientes del desánimo y desinterés de nuestros alumnos. Es indiscutible que existen dificultades por parte de los profesores a la hora de enseñar, pero también existen obstáculos por parte de los alumnos para aprender. Esta problemática resulta evidente a la hora de resolver problemas. El proyecto, cuyas conclusiones presentamos, pretende ensayar nuevas formas de enseñanza/aprendizaje que responden a las recientes directrices del espacio Europeo. El proyecto está dirigido a potenciar la tarea del alumno a la hora de enfrentarse con un problema. Se basa fundamentalmente en la creación de guiones que ofrezcan al alumno las pautas a seguir a la hora de resolver problemas y que también le permitan realizar una auto-evaluación de los resultados obtenidos.

  1. Audiencias activas: participación de la audiencia social en la televisión

    Directory of Open Access Journals (Sweden)

    Natalia Quintas Froufe

    2014-07-01

    Full Text Available La combinación de redes sociales, segundas pantallas y televisión ha propiciado la aparición de una nueva relación de los espectadores con la televisión en la que los habituales roles del paradigma de la comunicación se han alterado. La televisión social ha dado pie al nacimiento de la audiencia social entendida como una fragmentación de la audiencia real en función de su interactividad en las redes sociales. Este trabajo pretende estudiar los elementos que contribuyen al éxito o fracaso de programas con un mismo formato en relación a la audiencia social. Para ello se han tomado como objeto de estudio los tres talent show que lanzaron las principales cadenas generalistas españolas en septiembre del año 2013. Se ha procedido a la observación del impacto de dichos programas en la red social Twitter empleando una ficha de elaboración propia y se desarrolló un sistema de categorías de análisis y códigos con el fin de recopilar toda la información recogida. Los resultados obtenidos indican que en el éxito de los programas analizados en audiencia social influye la actividad de la cuentas de los presentadores y del jurado. Las conclusiones alcanzadas tras este análisis de la experiencia española pueden servir como modelo de desarrollo de la audiencia social para otros países en los que esta no se encuentre tan extendida.

  2. Human Conditions for Teaching: The Place of Pedagogy in Arendt's "Vita Activa"

    Science.gov (United States)

    Higgins, Chris

    2010-01-01

    Background/Context: If education centrally involves self-cultivation, and the teacher's own robust selfhood is necessary for inspiring self-cultivation in students, then teacherly self-cultivation is a necessary condition of education. But teaching is seen as a helping profession, where helping others always seems, in practice if not in principle,…

  3. Efeitos de um programa de orientação de atividade física e nutricional sobre o nível de atividade física de mulheres fisicamente ativas de 50 a 72 anos de idade Efectos de un programa de orientacion de actividad física y nutricional sobre el nivel de actividad física de mujeres fisicamente activas de 50 a 72 años de edad Effects of an intervention program of physical activity and nutrition orientation on the physical activity level of physically active women aged 50 to 72 years old

    Directory of Open Access Journals (Sweden)

    Marcela Ferreira

    2005-06-01

    Full Text Available A promoção do estilo de vida mais ativo na terceira idade tem sido utilizada como estratégia de desenvolver melhora nos padrões de saúde e na qualidade de vida. O objetivo do presente estudo foi verificar o efeito de um programa de orientação de atividade física (AF e nutricional sobre o nível de atividade física (NAF de mulheres fisicamente ativas. A amostra foi composta de 64 senhoras de 50 a 72 anos de idade de São Caetano do Sul que participavam de um programa regular de ginástica. As senhoras foram alocadas em um dos quatro grupos: A nutrição (n: 17; B nutrição + atividade física (n: 17; C atividade física (n: 13; D controle (n: 15. Para avaliar o NAF foi utilizado o Questionário Internacional de Atividade Física IPAQ. O programa de intervenção foi realizado durante 12 semanas, uma vez por semana, por 5 a 10 minutos após as aulas de ginástica. As orientações nutricionais foram baseadas na nutrição saudável e as de AF fundamentadas na mensagem do Agita São Paulo, que estimula, pelo menos 30 minutos por dia, na maior parte dos dias da semana, de forma contínua ou acumulada, atividades físicas em intensidade moderada, além das aulas de ginástica. Os resultados indicaram aumento na freqüência (vezes/semana das atividades moderadas (32,4%; 49,6%; 47,9%; p La promoción de un estilo de vida mas activo en la tercera edad viene siendo utilizada como una estartegia de promover la mejora de los padrones de salud y calidad de vida. El objetivo de este trabajo fué el de verificar el efecto de un programa de orientación en la actividad física (AF y nutricional sobre el nivel de actividad física (NAF de mujeres físicamente activas. La muestra estubo compuesta por 64 mujeres de edades entre los 50 y 72 años de San Caetano del Sur (Brasil que participaron en un programa de regular de gimnasia. Las señoras fueron ubicadas en uno de cuatro grupos: A nutrición (n: 17; B nutrición + actividad física (n: 17; C

  4. High Prevalence of Neutrophil Cytoplasmic Autoantibodies in Infants with Food Protein-Induced Proctitis/Proctocolitis: Autoimmunity Involvement?

    Czech Academy of Sciences Publication Activity Database

    Sekerková, A.; Fuchs, M.; Cecrdlová, E.; Šváchová, V.; Kralová Lesná, I.; Stříž, I.; Tlaskalová-Hogenová, Helena

    2015-01-01

    Roč. 2015, September 2015 (2015), s. 902863 ISSN 2314-8861 R&D Projects: GA MZd(CZ) NT13483 Institutional support: RVO:61388971 Keywords : INDUCED ENTEROCOLITIS SYNDROME * INFLAMMATORY-BOWEL-DISEASE * BREAST-FED INFANTS Subject RIV: EE - Microbiology, Virology Impact factor: 2.812, year: 2015

  5. Is there more than one proctitis syndrome? A revisitation using data from the TROG 96.01 trial

    International Nuclear Information System (INIS)

    Capp, Anne; Inostroza-Ponta, Mario; Bill, Dana; Moscato, Pablo; Lai, Chi; Christie, David; Lamb, David; Turner, Sandra; Joseph, David; Matthews, John; Atkinson, Chris; North, John; Poulsen, Michael; Spry, Nigel A.; Tai, Keen-Hun; Wynne, Chris; Duchesne, Gillian; Steigler, Allison; Denham, James W.

    2009-01-01

    Purpose: We sought to categorize longitudinal radiation-induced rectal toxicity data obtained from men participating in a randomised controlled trial for locally advanced prostate cancer. Materials and methods: Data from self-assessed questionnaires of rectal symptoms and clinician recorded remedial interventions were collected during the TROG 96.01 trial. In this trial, volunteers were randomised to radiation with or without neoadjuvant androgen deprivation. Characterization of longitudinal variations in symptom intensity was achieved using prevalence data. An integrated visualization and clustering approach based on memetic algorithms was used to define the compositions of symptom clusters occurring before, during and after radiation. The utility of the CTC grading system as a means of identifying specific injury profiles was evaluated using concordance analyses. Results: Seven well-defined clusters of rectal symptoms were present prior to treatment, 25 were seen immediately following radiation and 7 at years 1, 2 and 3 following radiation. CTC grading did not concord with the degree of rectal 'distress' and 'problems' at all time points. Concordance was not improved by adding urgency to the CTC scale. Conclusions: The CTC scale has serious shortcomings. A powerful new technique for non-hierarchical clustering may contribute to the categorization of rectal toxicity data for genomic profiling studies and detailed patho-physiological studies

  6. Did L Strains Responsible for Lymphogranuloma Venereum Proctitis Spread Among People With Genital Chlamydia trachomatis Infection in France in 2013?

    Science.gov (United States)

    Touati, Arabella; Vernay-Vaisse, Chantal; Janier, Michel; Le Hen, Isabelle; Charlois, Cécile; Dhotte, Philippe; Decré, Dominique; Bébéar, Cécile; de Barbeyrac, Bertille

    2016-06-01

    We retrospectively analyzed 1802 nonrectal Chlamydia trachomatis-positive specimens to determine if the L strains responsible for rectal Lymphogranuloma venereum in men who have sex with men could spread to the heterosexual population. No evidence for Lymphogranuloma venereum transmission among heterosexuals in France was observed in 2013. L2b strains seem to be restricted to the men who have sex with men population.

  7. Actitudes Éticas de los estudiantes y egresados en carrera de medicina con metodologías activas

    Directory of Open Access Journals (Sweden)

    Maria Rita Carvalho Garbi Novaes

    Full Text Available El presente estudio tiene por objeto desarrollar un diagnostico de la inserción integrada de la ética en la carrera demedicina brasileña con una metodología de aprendizaje basada en problemas y describir las percepciones de actitudes éticas de los estudiantes y egresados. El diseño metodológico es un estudio de caso, descriptivo y documental, con abordaje cualitativo y cuantitativo. La muestra de esta investigación ha sido constituida por 120 estudiantes y 40 egresados de dos promociones del Curso de Medicina de la ESCS. Este proyecto fue aprobado por el Comité de Ética en Investigación - SES/DF. Los estudiantes y egresados de la ESCS demostraron un buen manejo en el abordaje de los conflictos éticos y respeto a los pacientes. Sin embargo, el análisis de sensibilidad ética mostró una fragilidad en las percepciones y aptitudes inapropiadas de los estudiantes de la carrera de medicina, identificada básicamente en los años iniciales, que necesitan más discusiones sistematizadas sobre los aspectos éticos y bioéticos integrados a las actividades prácticas para estimular y fortalecer la reflexión ética de los estudiantes

  8. Manutenção preditiva e pró-activa: filosofias alternativas ou complementares: estudo de caso

    OpenAIRE

    Santos, Flávio Manuel Casqueiro

    2013-01-01

    Trabalho Final de Mestrado para obtenção do grau de Mestre em Engenharia Mecânica Ramo Manutenção e Produção A manutenção nos dias de hoje ocupa uma importante função estratégica para qualquer organização sendo os seus custos um factor determinante para a competitividade, produtividade das organizações. Logo é essencial que a manutenção apresente uma vertente mais científica e organizada, capaz não só de manter os itens físicos nas melhores condições possíveis de funcionamento, mas também ...

  9. MÉTODO DE CASOS. UNA METODOLOGÍA ACTIVA PARA ADQUIRIR APRENDIZAJES SIGNIFICATIVOS EN QUÍMICA

    Directory of Open Access Journals (Sweden)

    Clotilde Pizarro

    2015-01-01

    Full Text Available En este trabajo se aplica lametodología de casos en estudiantes de primer año de la carrera de Ingeniería en Prevención de Riesgos y Medioambiente. Para lo cual se presenta un caso real de contaminación, ocurrido en una escuela de la región de Valparaíso llamada “La Greda”. Se inicia la aplicación del caso entregando un extracto de la información recolectada de los medios de información y se les realiza una breve inducción acerca de la metodología a aplicar. Luego se realiza un plenario, en el que se debate acercade las posibles soluciones al problema y estableciendo una relación entre el caso y las unidades del programa de química.Se concluye que la aplicación del método de casos, fue una herramienta fructífera en los rendimientos obtenidos por los estudiantes, ya que el porcentaje de aprobación en promedio fue de un 75%, el cual es considerablemente mayor que años anteriores.

  10. LA VIOLENCIA FAMILIAR Y SU INFLUENCIA EN LA VIOLENCIA ESCOLAR (BULLYING) ACTIVA, PASIVA Y TESTIGO EN ALUMNOS DE SECUNDARIA

    OpenAIRE

    Rodolfo Sergio González Castro

    2015-01-01

    International audience; Investigación aplicada en la que se sometió a prueba la hipótesis de que la Violencia Familiar es factor explicativo del involucramiento de los alumnos de secundaria en actividades de Violencia Escolar (Bullying). Los resultados obtenidos indican que un 21.6 % de los alumnos obtuvieron puntuaciones que los ubican en un nivel Alto en los indicadores de Violencia Familiar. En cuanto al Involucramiento General de los alumnos en Violencia Escolar (bullying), el 20.3 % obtu...

  11. De la crueldad activa: lecturas de Nietzsche en la obra de Leopoldo María Panero

    Directory of Open Access Journals (Sweden)

    Joaquín Ruano

    2013-12-01

    Full Text Available El presente artículo aborda, desde una perspectiva crítica, la importancia de los textos de Friedrich Nietzsche en la obra del poeta Leopoldo María Panero, y cómo estas lecturas configuran uno de los soportes principales a la hora de elaborar una estética y una epistemología basada en el ataque y la transgresión de los sistemas morales establecidos.

  12. Teología de la evolución (I): La autotrascendencia activa. Karl Rahner, 1961

    OpenAIRE

    Manuel G. Doncel

    2015-01-01

    Este artículo es el primero de una tríada en la que se presentarán tres intuiciones que creemos valiosas para elaborar hoy día una rica teología de la «creación en evolución» (las otras dos serán: 2. La llamada creativa trinitaria, según Karl Schmitz-Moormann, 1997, y 3. El Espíritu como fuente de novedad, según Denis Edwards, 2004). Quisiéramos entender, a nivel filosófico y teológico, esa «cosmo-bio-evolución» que es nuestra propia «mega historia». Comenzamos hoy por preguntarnos cómo expli...

  13. LAS POLÍTICAS ACTIVAS DE EMPLEO EN MÉXICO: EL CASO DE LOS PROGRAMAS DE FORMACIÓN

    Directory of Open Access Journals (Sweden)

    David Cervantes Arenillas

    2011-06-01

    Full Text Available In last decades, the active labor market policies have become an important instrument to promote and improve the employability of the active population. In México, the active labor market policies has experimented transformations in its structure and evolution, in these sense, the objective of this paper is answer two basic questions: What has been the impacts of the active labor market policies in México from 2000 to 2010? And, What factors are related to improve the employability of the training programs?.To answer the last question, a logistic model is made based on the data of beneficiaries of training programs in Mexico in 2008. The model allows determinate the individual characteristics associated in the improvement of employability, which could be useful on targeting training policies.

  14. Recubrimientos vítreos de cerio para la protección activa de aleaciones de aluminio

    OpenAIRE

    Yhasmin Reyes; Alicia Durán; Yolanda Castro

    2015-01-01

    Las buenas propiedades mecánicas, alta conductividad eléctrica y térmica y bajo coste de mecanización del aluminio y sus aleaciones, permiten su uso en un amplio campo de aplicaciones. Sin embargo, al exponerse a ambientes agresivos, el aluminio sufre corrosión localizada. En este trabajo, se estudia la preparación de recubrimientos vítreos de óxido de cerio, sintetizados a partir de nitrato de cerio y diversos complejantes para mejorar la resistencia a la corrosión de las aleaciones AA2024 y...

  15. Actitudes Éticas de los estudiantes y egresados en carrera de medicina con metodologías activas

    Science.gov (United States)

    Novaes, Maria Rita Carvalho Garbi; Novaes, Luiz Carlos Garcez; Guilhem, Dirce; Stepke, Fernando Lolas; Silveira, Carla Cristina Costa; Komatsu, Ricardo Shoiti; Trindade, Eliane Mendonça Vilar; Guiotti, Murilo Galvão

    2010-01-01

    El presente estudio tiene por objeto desarrollar un diagnostico de la inserción integrada de la ética en la carrera de medicina brasileña con una metodología de aprendizaje basada en problemas y describir las percepciones de actitudes éticas de los estudiantes y egresados. El diseño metodológico es un estudio de caso, descriptivo y documental, con abordaje cualitativo y cuantitativo. La muestra de esta investigación ha sido constituida por 120 estudiantes y 40 egresados de dos promociones del Curso de Medicina de la ESCS. Este proyecto fue aprobado por el Comité de Ética en Investigación - SES/DF. Los estudiantes y egresados de la ESCS demostraron un buen manejo en el abordaje de los conflictos éticos y respeto a los pacientes. Sin embargo, el análisis de sensibilidad ética mostró una fragilidad en las percepciones y aptitudes inapropiadas de los estudiantes de la carrera de medicina, identificada básicamente en los años iniciales, que necesitan más discusiones sistematizadas sobre los aspectos éticos y bioéticos integrados a las actividades prácticas para estimular y fortalecer la reflexión ética de los estudiantes. PMID:20981242

  16. Tectónica Activa y Geodinámica en el Norte de Centroamérica

    OpenAIRE

    Álvarez Gómez, José Antonio

    2016-01-01

    El norte de Centroamérica puede ser entendido geográficamente como el área comprendida por Nicaragua, Honduras, El Salvador, Guatemala y el sur de México (Chiapas). Geológicamente es un bloque de corteza continental soldado parcialmente a la placa de Caribe, el bloque de Chortís, siendo su extremo nor-occidental. Este bloque limita con dos placas litosféricas, al noroeste con la placa de Norteamérica a través de la zona de desgarre siniestra de Motagua – Polochic – Transformante de la Isla de...

  17. Visión activa y aprendizaje perceptual: Cómo la experiencia cambia nuestro mundo visual

    Directory of Open Access Journals (Sweden)

    Carlos M. Hamamé

    2011-06-01

    Full Text Available Nuestra experiencia es capaz de modificar el modo en que percibimos. Este tipo de aprendizaje perceptual nos indica la importancia del observador en la construcción de la percepción. En este artículo se examinan evidencias neurofisiológicas recientes que demuestran la presencia, no sólo de procesos perceptuales, sino también atencionales y de actualización de contexto, en el modo en que nuestra percepción visual cambia con la experiencia. Considerar la experiencia sensorial, junto con el estado actual del observador, ayudará a completar los modelos actuales, que son insuficientes para explicar la visión en condiciones naturales.

  18. Expresión de toxinas activas para larvas de mosquito por una cepa nativa de Asticaccaulis excentricus

    Directory of Open Access Journals (Sweden)

    Sergio Ordúz

    2000-02-01

    Full Text Available

    El control de mosquitos con insecticidas biológicos, como las toxinas producidas por especies del género Bacillus ha sido usado ampliamente en muchos países. Sin embargo, la rápida sedimentación de éstas las coloca fuera del alcance de la zona de alimentación de las larvas de mosquito. Con el propósito de resolver este problema se ha propuesto clonar los genes de dichas toxinas en bacterias acuáticas que son capaces de vivir y multiplicarse en la parte superior de la columna de agua, donde se alimentas los mosquitos anofelinos. Se escogieron dos cepas de la bacteria acuática Asticaccaulis excentricus para expresar los genes de la toxina binaria de B. sphaericus y el gen cry11Bb de B. thuringiensis subesp. Medellín clonados en un vector de expresión adecuado. En experimentos de alimentación se encontró que larvas de las especies Culex quinquefasciatus, Aedes aegypti y Anopheles albimanus fueron capaces de sobrevivir en una dieta basada exclusivamente en esta bacteria gram negativa. Las células de A. excentricus recombinante fueron capaces de expresar ambos genes, pero solamente la cepa expresando los genes de la toxina binaria de B. sphaericus fue tóxica para larvas de mosquito. Extractos de proteasas de A. excentricus no degradaron la toxina Cry11Bb, lo que indica que es otro el mecanismo que interfiere con la expresión de la toxicidad de la toxina Cry11Bb en esta bacteria recombinante. Los experimentos de flotación mostraron que A. excentricus recombiante se mantiene en la parte superior de la columna de agua al igual que las cepas nativas, y por más tiempo que las cepas de Bacillus.

  19. Celiac disease (CD), ulcerative colitis (UC), and primary sclerosing cholangitis (PSC) in one patient: a family study Enfermedad celiaca (EC), colitis ulcerosa (CU) y colangitis esclerosante primaria (CEP) asociadas en el mismo paciente: estudio familiar

    OpenAIRE

    V. Cadahía; L. Rodrigo; D. Fuentes; S. Riestra; R. de Francisco; M. Fernández

    2005-01-01

    We discuss the case of a 17-year-old male who at the age of 7 was diagnosed with celiac disease (CD) together with ulcerative colitis (UC) and primary sclerosing cholangitis (PSC). The patient was treated with gluten-free diet and immunosuppressive drugs (azathioprine), and currently remains asymptomatic. The patient's younger, 12-year-old sister was diagnosed with CD when she was 1.5 years old, and at 7 years she developed type-I diabetes mellitus, which was difficult to control. A family st...

  20. Sucralfate versus mesalazine versus hydrocortisone in the prevention of acute radiation proctitis during conformal radiotherapy for prostate carcinoma. A randomized study

    International Nuclear Information System (INIS)

    Sanguineti, G.; Franzone, P.; Marcenaro, M.; Vitale, V.; Foppiano, F.

    2003-01-01

    Purpose: To assess whether the topical use of steroids or 5-aminosalicylic acid (5-ASA) is superior to sucralfate in preventing acute rectal toxicity during three-dimensional conformal radiotherapy (3DCRT) to 76 Gy. Patients and Methods: Patients undergoing 3DCRT for prostate carcinoma at our institution were offered to be randomized to sucralfate 3 g in 15 ml suspension enema (Antepsin trademark ), mesalazine 4 g gel enema (Enterasyn trademark), or hydrocortisone 100 mg foam enema (Colifoam trademark ). Randomization was blind to the treating physician but not to the patient. Sucralfate was chosen as control arm. Topical treatment had to be performed once daily, starting on day 1 of 3DCRT. Acute rectal toxicity was scored weekly according to RTOG criteria. Time to occurrence of grade 2+ acute rectal toxicity was taken as endpoint. Results: The trial was opened in August 1999, and after the first 24 patients had been treated, arm 2 was discontinued because of eight patients receiving mesalazine, seven actually developed acute rectal toxicity (five patients grade 3 and two patients grade 2). Until May 2001, 134 consecutive patients were randomly assigned to sucralfate (63 patients), mesalazine (eight patients) or hydrocortisone (63 patients). The cumulative incidence of acute rectal toxicity at the end of treatment by arm is 61.9 ± 6.1%, 87.5 ± 11.7%, and 52.4 ± 6.2% for arms 1, 2, and 3, respectively. The difference between the mesalazine group and the sucralfate group is highly significant (hazard ratio [HR] 2.5, 95% confidence interval [CI] 1.1-5.7; p = 0.03). At both uni- and multivariate analysis taking into account several patients and treatment covariates, the difference between hydrocortisone and sucralfate is not significant (HR 0.7, 95% CI 0.5-1.2; p = 0.2). Conclusion: Topical mesalazine is contraindicated during radiotherapy. Hydrocortisone enema is not superior to sucralfate in preventing acute rectal toxicity. (orig.)

  1. Sucralfate versus mesalazine versus hydrocortisone in the prevention of acute radiation proctitis during conformal radiotherapy for prostate carcinoma. A randomized study.

    Science.gov (United States)

    Sanguineti, Giuseppe; Franzone, Paola; Marcenaro, Michela; Foppiano, Franca; Vitale, Vito

    2003-07-01

    To assess whether the topical use of steroids or 5-aminosalicylic acid (5-ASA) is superior to sucralfate in preventing acute rectal toxicity during three-dimensional conformal radiotherapy (3DCRT) to 76 Gy. Patients undergoing 3DCRT for prostate carcinoma at our institution were offered to be randomized to sucralfate 3 g in 15 ml suspension enema (Antepsin, mesalazine 4 g gel enema (Enterasyn, or hydrocortisone 100 mg foam enema (Colifoam. Randomization was blind to the treating physician but not to the patient. Sucralfate was chosen as control arm. Topical treatment had to be performed once daily, starting on day 1 of 3DCRT. Acute rectal toxicity was scored weekly according to RTOG criteria. Time to occurrence of grade 2+ acute rectal toxicity was taken as endpoint. The trial was opened in August 1999, and after the first 24 patients had been treated, arm 2 was discontinued because of eight patients receiving mesalazine, seven actually developed acute rectal toxicity (five patients grade 3 and two patients grade 2). Until May 2001, 134 consecutive patients were randomly assigned to sucralfate (63 patients), mesalazine (eight patients) or hydrocortisone (63 patients). The cumulative incidence of acute rectal toxicity at the end of treatment by arm is 61.9 +/- 6.1%, 87.5 +/- 11.7%, and 52.4 +/- 6.2% for arms 1, 2, and 3, respectively. The difference between the mesalazine group and the sucralfate group is highly significant (hazard ratio [HR] 2.5, 95% confidence interval [CI] 1.1-5.7; p = 0.03). At both uni- and multivariate analysis taking into account several patients and treatment covariates, the difference between hydrocortisone and sucralfate is not significant (HR 0.7, 95% CI 0.5-1.2; p = 0.2). Topical mesalazine is contraindicated during radiotherapy. Hydrocortisone enema is not superior to sucralfate in preventing acute rectal toxicity.

  2. Sucralfate versus mesalazine versus hydrocortisone in the prevention of acute radiation proctitis during conformal radiotherapy for prostate carcinoma. A randomized study

    Energy Technology Data Exchange (ETDEWEB)

    Sanguineti, G.; Franzone, P.; Marcenaro, M.; Vitale, V. [Dept. of Radiation Oncology, National Inst. for Cancer Research, Genova (Italy); Foppiano, F. [Dept. of Physics, National Inst. for Cancer Research, Genova (Italy)

    2003-07-01

    Purpose: To assess whether the topical use of steroids or 5-aminosalicylic acid (5-ASA) is superior to sucralfate in preventing acute rectal toxicity during three-dimensional conformal radiotherapy (3DCRT) to 76 Gy. Patients and Methods: Patients undergoing 3DCRT for prostate carcinoma at our institution were offered to be randomized to sucralfate 3 g in 15 ml suspension enema (Antepsin {sup trademark}), mesalazine 4 g gel enema (Enterasyn trademark), or hydrocortisone 100 mg foam enema (Colifoam {sup trademark}). Randomization was blind to the treating physician but not to the patient. Sucralfate was chosen as control arm. Topical treatment had to be performed once daily, starting on day 1 of 3DCRT. Acute rectal toxicity was scored weekly according to RTOG criteria. Time to occurrence of grade 2+ acute rectal toxicity was taken as endpoint. Results: The trial was opened in August 1999, and after the first 24 patients had been treated, arm 2 was discontinued because of eight patients receiving mesalazine, seven actually developed acute rectal toxicity (five patients grade 3 and two patients grade 2). Until May 2001, 134 consecutive patients were randomly assigned to sucralfate (63 patients), mesalazine (eight patients) or hydrocortisone (63 patients). The cumulative incidence of acute rectal toxicity at the end of treatment by arm is 61.9 {+-} 6.1%, 87.5 {+-} 11.7%, and 52.4 {+-} 6.2% for arms 1, 2, and 3, respectively. The difference between the mesalazine group and the sucralfate group is highly significant (hazard ratio [HR] 2.5, 95% confidence interval [CI] 1.1-5.7; p = 0.03). At both uni- and multivariate analysis taking into account several patients and treatment covariates, the difference between hydrocortisone and sucralfate is not significant (HR 0.7, 95% CI 0.5-1.2; p = 0.2). Conclusion: Topical mesalazine is contraindicated during radiotherapy. Hydrocortisone enema is not superior to sucralfate in preventing acute rectal toxicity. (orig.)

  3. Acute symptoms, not rectally administered sucralfate, predict for late radiation proctitis: longer term follow-up of a phase III trial--Trans-Tasman Radiation Oncology Group.

    Science.gov (United States)

    O'Brien, Peter C; Franklin, C Ian; Poulsen, Michael G; Joseph, David J; Spry, Nigel S; Denham, James W

    2002-10-01

    To assess the potential for sucralfate administered rectally to reduce the risk of late rectal morbidity in patients undergoing nonconformal radiotherapy (RT) for carcinoma of the prostate and to study the variables potentially contributing to late rectal morbidity and particularly to explore the relationship between acute and late toxicity. Eighty-six patients with localized prostate carcinoma were randomized in a double-blind, placebo-controlled study to a daily enema of 3 g of sucralfate in a 15-mL suspension or the same suspension without sucralfate. The enema began the first day of RT and was continued for 2 weeks after treatment completion. The primary end point of the study was acute Radiation Therapy Oncology Group (RTOG)/European Organization for Research and Treatment of Cancer (EORTC) toxicity; however, the patients were followed for an additional 5 years on a 6-month basis. The evaluation included late RTOG/EORTC toxicity and a patient self-assessment questionnaire. With a median follow-up of 5 years, the Kaplan-Meier probability of late Grade 2 RTOG/EORTC toxicity was 12% (95% confidence interval [CI] 2-22%) for placebo and 5% (95% CI 0-12%) for sucralfate (p = 0.26). The probability of late rectal bleeding was 59% (95% CI 45-73%) for placebo and 54% (95% CI 40-68%) for sucralfate. No statistically significant difference was found between the treatment arms for the peak incidence of any of the other patient self-assessment variables. Cox proportional hazards modeling indicated acute RTOG/EORTC toxicity of Grade 2 or greater was associated with a hazard ratio of 2.74 (95% CI 1.31-5.73) for the development of late toxicity of Grade 1 or greater. Substituting the patient self-assessment variables for acute RTOG/EORTC toxicity revealed that rectal pain of a moderate or severe grade during RT was the best predictor of the subsequent development of late toxicity, with a hazard ratio of 3.44 (95% CI 1.68-7). The results of this study do not support the use of sucralfate administered rectally as a method for reducing the late toxicity of nonconformal RT for prostate cancer. There appears to be an association between the development of acute and subsequent late toxicity, although the nature of this association remains to be determined.

  4. Acute symptoms, not rectally administered sucralfate, predict for late radiation proctitis: longer term follow-up of a phase III trial--Trans-Tasman Radiation Oncology Group

    International Nuclear Information System (INIS)

    O'Brien, Peter C.; Franklin, C. Ian; Poulsen, Michael G.; Joseph, David J.; Spry, Nigel S.; Denham, James W.

    2002-01-01

    Purpose: To assess the potential for sucralfate administered rectally to reduce the risk of late rectal morbidity in patients undergoing nonconformal radiotherapy (RT) for carcinoma of the prostate and to study the variables potentially contributing to late rectal morbidity and particularly to explore the relationship between acute and late toxicity. Methods and Materials: Eighty-six patients with localized prostate carcinoma were randomized in a double-blind, placebo-controlled study to a daily enema of 3 g of sucralfate in a 15-mL suspension or the same suspension without sucralfate. The enema began the first day of RT and was continued for 2 weeks after treatment completion. The primary end point of the study was acute Radiation Therapy Oncology Group (RTOG)/European Organization for Research and Treatment of Cancer (EORTC) toxicity; however, the patients were followed for an additional 5 years on a 6-month basis. The evaluation included late RTOG/EORTC toxicity and a patient self-assessment questionnaire. Results: With a median follow-up of 5 years, the Kaplan-Meier probability of late Grade 2 RTOG/EORTC toxicity was 12% (95% confidence interval [CI] 2-22%) for placebo and 5% (95% CI 0-12%) for sucralfate (p=0.26). The probability of late rectal bleeding was 59% (95% CI 45-73%) for placebo and 54% (95% CI 40-68%) for sucralfate. No statistically significant difference was found between the treatment arms for the peak incidence of any of the other patient self-assessment variables. Cox proportional hazards modeling indicated acute RTOG/EORTC toxicity of Grade 2 or greater was associated with a hazard ratio of 2.74 (95% CI 1.31-5.73) for the development of late toxicity of Grade 1 or greater. Substituting the patient self-assessment variables for acute RTOG/EORTC toxicity revealed that rectal pain of a moderate or severe grade during RT was the best predictor of the subsequent development of late toxicity, with a hazard ratio of 3.44 (95% CI 1.68-7). Conclusion: The results of this study do not support the use of sucralfate administered rectally as a method for reducing the late toxicity of nonconformal RT for prostate cancer. There appears to be an association between the development of acute and subsequent late toxicity, although the nature of this association remains to be determined

  5. Propuestas transmedia y gamificación aplicadas al EEES: Nuevas metodologías activas para implementar las competencias en Ciencias Sociales y en Literatura

    OpenAIRE

    Gómez Trigueros, Isabel María; Ruiz Bañuls, Mónica; Ortega Sánchez, Delfín; García-Valero, Benito Elías; Juan Penalva, Joaquín; Segrelles, José Antonio; Formosinho, Maria das Dores

    2017-01-01

    El propósito de esta RED es presentar una reflexión rigurosa en el contexto educativo de la docencia en los Grados de Educación Infantil y de Educación Primaria así como en los Grados de Lengua y Literatura y de Geografía y en el Master de Educación Secundaria en la que abordamos las aportaciones innovadoras de la gamificación y los transmedia para la implementación de procesos didácticos en los que se combinen la labor cooperativa, la resolución de problemas o ABP. De igual modo se valora la...

  6. Análisis de metodologías activas con ABP, Transmedia y Gamificación para implementar las competencias en Ciencias Sociales y en Literatura

    OpenAIRE

    Gómez Trigueros, Isabel María; Ruiz Bañuls, Mónica

    2017-01-01

    El propósito de este estudio es mostrar una reflexión rigurosa en torno a una detallada investigación realizada en el contexto educativo de la docencia en el Master de Educación Secundaria en la que abordamos las aportaciones innovadoras de la gamificación y los transmedia para la implementación de procesos didácticos en los que se combinen la labor cooperativa, la resolución de problemas o ABP así como la utilización de las Tecnologías de la Información y la Comunicación como instrumentos pa...

  7. Los pacientes trasladados desde otro centro: fuente de infección de microorganismos multiresistentes. resultados de seis años de programa de vigilancia activa

    Directory of Open Access Journals (Sweden)

    E. Beatrice Hervé, Dra.

    2014-05-01

    Resultados: En los años estudiados la tasa de positividad para MOMR osciló entre 16,4% y 9,8%. La distribución por MOMR, para el conjunto de los años en estudio, fue la siguiente: SAMR un 20–25%; ERV, entre 35 y 49% y; B Gram negativos un 38–60%. Por otro lado, la sensibilidad del sistema de vigilancia evaluada durante el primer semestre de 2010 fue de un 91% para aislamiento y de un 93% para los cultivos. En base a los resultados obtenidos durante primer semestre de 2011 de características de pacientes colonizados, se estableció el 2012 un algoritmo que considera: centro de origen, edad, tiempo de permanencia en centro de origen y unidad de destino, para definir la necesidad de dejar o no a un paciente trasladado con medidas de aislamiento. Esto permite realizar una acción más racional y costo-efectiva para el control de MOMR en nuestro establecimiento, reduciendo la carga de aislamientos y cultivos en un 20%.

  8. Reduction of the harmonic propagation in three-phase systems using active compensation; Reduccion de la propagacion armonica en sistemas trifasicos empleando compensacion activa

    Energy Technology Data Exchange (ETDEWEB)

    Contreras Ordaz, Marco Antonio

    2007-08-15

    With the development of semiconductor devices and the increase of non-linear loads based on static power converters, the power quality of transmission, distribution and consumption systems has been affected. The harmonics present in a distribution system are mainly result of the current harmonics generated by the non-linear loads and their effect on the impedance of the distribution system. There are several problems generated by the presence of current and voltage harmonics in a power distribution system. One of these problems is the harmonic propagation phenomenon, which has become important on the matter of power distribution systems. This phenomenon is manifested by the harmonic voltage amplification in distribution lines, generating levels of distortion that affect the electric facilities, and the life expectancy of equipment (CA motors, transformers, capacitor banks, etc.). There is also a reduction in the power transmission capacity of electric distribution lines. The harmonic propagation is mainly produced by the resonance between the line impedance and the power factor correction of capacitor banks installed along the distribution line and the consumers' equipment. The utilization of passive filters is not a sufficient solution, because the harmonic propagation exists even with no loads on the electric network, and the resonance frequencies do not correspond to the characteristic harmonics. This problem is solved by using active filters in radial distribution systems, mainly in low voltage. The objective of using an active filter is neither to compensate a particular load, nor a group of centralized loads; its objective is to reduce the voltage distortion and avoid the harmonic propagation by placing the filter in a branch of feeder of the electric system. This thesis presents a thorough study of the harmonic propagation phenomenon in ring networks and its damping with an active filter. An important point is to identify the location of the active filter in the ring network in order to get the best reduction with the smallest power capacity. The research includes topic related with the detection of characteristic and non-characteristic harmonics, the use of shunt active filters connected directly to the network, and harmonic reduction in electric systems. [Spanish] Con el desarrollo de dispositivos semiconductores y la proliferacion de cargas no lineales basadas en convertidores de potencia estaticos, la calidad de la energia electrica en sistemas de transmision, distribucion y consumo se ha visto afectada. Los armonicos de tension presentes en un sistema de distribucion son principalmente el resultado de las corrientes armonicas generadas por las cargas no lineales y su efecto sobre la impedancia del sistema de distribucion. Existen varios problemas generados por la presencia de armonicos de corriente y tension en sistemas de distribucion de potencia; uno de estos problemas es el fenomeno de la propagacion armonica que ha tomado relevancia en los sistemas de distribucion y consumo. Este fenomeno se ha manifestado por la amplificacion de armonicos de tension en lineas de distribucion, generando niveles de distorsion que afectan a la instalaciones electricas, y afectando la vida util de algunos equipos (motores de CA, transformadores, bancos de capacitores, etc.). Ademas hay una reduccion en la capacidad de transmision de potencia en las lineas de distribucion. La propagacion armonica es causada principalmente por la resonancia serie/paralelo entre la impedancia de la linea, los transformadores y los bancos de correccion de factores de potencia instalados a lo largo de la linea de distribucion y los equipos de los consumidores. Los filtros pasivos no han sido una solucion suficiente porque la propagacion armonica puede ocurrir cuando no existe carga en la red electrica, y las frecuencias de resonancia pueden no corresponder a armonicos caracteristicos. Este problema ha sido resuelto por medio del uso de filtros activos en sistemas de distribucion radial, principalmente en bajo voltaje. El objetivo de los filtros activos no es compensar una carga en particular, o un grupo de cargas centralizadas; el objetivo es reducir la distorsion de voltaje y evitar la propagacion armonica colocando el filtro en una rama o alimentador del sistema electrico. En esta tesis se presenta un estudio del comportamiento del fenomeno de la propagacion armonica en la red anillo y su amortiguamiento con un filtro activo. Un punto importante es la localizacion del filtro dentro del sistema de distribucion; en este nodo se debe inyectar la menor cantidad de corriente de amortiguamiento y realizar la mejor reduccion de las resonancias. La investigacion envuelve topicos relacionados con la deteccion de armonicos caracteristicos y no caracteristicos, el uso de filtros con conexion directa a la red, y la reduccion armonica en el sistema electrico.

  9. Inventario de Leguminosas activas y evaluación de su potencial de nitrificación, en zonas secas del cantón Paltas.

    OpenAIRE

    Orellana Malla, Gloria Esmeralda

    2007-01-01

    Las leguminosas, grupo de plantas muy numeroso, que incluye unas 17000 especies, antes considerado como una única familia y en la actualidad agrupadas en el orden Fabales. Las leguminosas tienen una gran importancia desde el punto de vista económico ya que incluyen muchas especies que se utilizan como alimento, por ejemplo la arveja, el fréjol, el maní; algunas otras que son productoras de aceite, como la soya; otras de interés forrajero como el trébol y la alfalfa o especies ornamentales com...

  10. Influencia del deporte de impacto en la disfunción del suelo pélvico en la mujer activa

    OpenAIRE

    Santesteban López, Leyre

    2014-01-01

    Antecedentes: la pubalgia o dolor púbico (inguinal) ocurre principalmente en futbolistas y atletas corredores. Los mecanismos responsables son gestos repetitivos, cambios repentinos de ritmo, velocidad y dirección, giros bruscos. Las estructuras involucradas son el aductor largo, recto del abdomen, iliopsoas y sínfisis del pubis. Objetivos: Revisar la evidencia científica en relación a las pruebas clínicas exploratorias y programas de tratamiento conservador y preventivo más adecuados para...

  11. Jóvenes comprometidos en la Red: el papel de las redes sociales en la participación social activa

    Directory of Open Access Journals (Sweden)

    Mª Carmen García Galera

    2014-07-01

    Full Text Available Este trabajo analiza el papel que las redes sociales juegan en la movilización ciudadana, social y solidaria de los jóvenes españoles. El objetivo es observar si son responsables de que los jóvenes activos online demuestren también su compromiso en la vida fuera de la Red, y si su predisposición existente o no hacia la participación, se intensifica a través de estas redes sociales y en su respuesta offline. Para ello se desarrolló una investigación online a través de cuestionario –con preguntas en Escala de Likert y de elección múltiple– en colaboración con la red social Tuenti en la que participaron más de 1.300 jóvenes. Los resultados ponen de manifiesto porcentajes significativos de participación solidaria exclusivamente online, si bien se observa que más del 80% de los jóvenes, de una u otra forma, participan en las acciones a las que se les convoca a través de redes sociales. El estudio examina también las formas de participación en acciones solidarias y la influencia de factores como la proximidad geográfica, social o emocional sobre la participación online y offline. Las redes sociales han cambiado el significado de la participación, están incentivando el compromiso y consiguiendo que jóvenes que no se movilizaban fuera de ellas, pasen a la acción. Por ello propone entre sus conclusiones, la necesidad de superar la dicotomía que opone online y offline en el ámbito de la participación social.

  12. ESTABLECIENDO RASTROS PARA LA CONSTITUCIÓN DE UNA PERSONA ACTIVA DE DERECHOS: EL CUERPO DE LA VIOLENCIA EN LA HISTORIA DE LOS MONTES DE MARÍA

    Directory of Open Access Journals (Sweden)

    Orlando Durango Rueda

    2007-08-01

    Full Text Available El trabajo rastrea en estos últimos años, el rostro de la violencia en los Montes de María, Bolívar; busca rescatar de estos grupos la historia de su capacidad de darse un territorio y unos imaginarios, que dejen de ser los de la fuerza y de la intimidación, para volverse posibilidad de pensar un espacio, unas relaciones y una cultura, alumbradas por la tolerancia, la confianza y sobre todo por la circulación de la palabra.

  13. Estrategias familiares para el tránsito a la vida activa de la juventud rural: modelos de inserción sociolaboral

    Directory of Open Access Journals (Sweden)

    CECILIA DÍAZ MÉNDEZ

    1999-01-01

    Full Text Available El presente trabajo se apoya en dos soportes teóricos fundamentales: por un lado, la corriente teórica que en Sociología Rural se conoce como Estudios Campesinos ; por otro lado, el estudio de las estrategias familiares en las familias campesinas. La investigación muestra cómo los padres elaboran estrategias de acción para orientar social y laboralmente el futuro de sus hijos e hijas, y esta orientación está determinada por el objetivo de continuidad de la explotación familiar de la que depende el grupo. A partir de este análisis se elaboran modelos de inserción sociolaboral de los jóvenes y las jóvenes y aparecen los factores que determinan que cada hijo / a se oriente en una u otra dirección. Este trabajo se ha desarrollado en la región asturiana y está basado en una metodología de tipo cualitativo con entrevistas en profundidad y grupos de discusión.

  14. Efecto de las estrategias didácticas activas en las actitudes hacia la química y su interacción con el estilo cognitivo

    Directory of Open Access Journals (Sweden)

    Gladys Elena Hurtado Osorio

    2015-01-01

    Full Text Available En este artículo se muestran y analizan los efectos en las actitudes hacia el aprendizaje de la química, con la aplicación de tres estrategias didácticas de enseñanza (aprendizaje basado en problemas — ABP— , aprendizaje por descubrimiento guiado —ADG — y enseñanza para la comprensión —EPC — en tres grupos de estudiantes de educación media, diferenciados por su estilo cognitivo en la dimensión dependencia- independencia de campo. Para el estudio se aplicó el instrumento de actitudes IAQ, que permite deter - minar las actitudes en tres dimensiones: afectiva, actitudinal y cognitiva. Los resultados mostraron, entre otros, una correlación significativa entre las actitudes en la dimensión cognitiva y el estilo cognitivo DIC.

  15. La web, las aplicaciones de las Matemáticas y las metodologías activas: Una propuesta para el aula

    Directory of Open Access Journals (Sweden)

    María José Pérez Peñalver

    2013-04-01

    Full Text Available Con el objetivo de implicar a los estudiantes en su aprendizaje y de que relacionen los contenidos que se imparten en las clases de matemáticas, se ha creado una pequeña práctica de aula en primero de Ingeniería Civil de la Universidad Politécnica de Valencia. En la tarea, los estudiantes investigan en grupo las aplicaciones de las cónicas y las cuádricas a través de la red. Posteriormente eligen varias aplicaciones y elaboran una pequeña presentación que comparten con el resto de grupos. Finalmente realizan la evaluación de la tarea, que ha sido una responsabilidad compartida entre el profesor y los grupos y se ha organizado en forma de concurso con un premio para el mejor. En el artículo se muestra la descripción detallada del proceso, los resultados obtenidos, el grado de satisfacción de los alumnos y del docente, los problemas que surgieron y las propuestas de mejora.

  16. 263. Resultado de la cirugía cardíaca en los pacientes con cirrosis hepática y endocarditis infecciosa activa

    Directory of Open Access Journals (Sweden)

    E. Quintana

    2012-04-01

    Conclusiones: Los pacientes con endocarditis y cirrosis son los de más riesgo. EuroSCORE no fue útil para la estratificación del riesgo. En pacientes con cirrosis avanzada la cirugía debe ofrecerse sólo en casos seleccionados.

  17. Metodologías activas para un aprendizaje del Derecho Romano basado en problemas: herencia, dote y régimen económico del matrimonio romano

    Directory of Open Access Journals (Sweden)

    Elisa Muñoz Catalán

    2013-06-01

    Full Text Available Con la realización del presente trabajo pretendemos investigar sobre la importancia actual de aplicar el aprendizaje basado en problemas a la enseñanza del Derecho Romano, frente a las tradicionales clases teóricas y magistrales. Incidiendo en el alcance de las exigencias metodológicas surgidas con los nuevos planes del estudio del Grado en Derecho, en el marco del EEES; así como en el desarrollo de una serie de competencias en los estudiantes, que les van a ser muy útiles una vez que finalicen y se enfrenten a las dificultades del mercado de trabajo, ya que se consideran como los verdaderos protagonistas del proceso de enseñanza-aprendizaje. Por tanto, con la puesta en práctica de este primer caso sobre el régimen económico del matrimonio frente a otras parejas de hecho como el concubinato, la dote y el papel de la mujer, las formas de esclavitud o la herencia, acercamos al alumnado al casuismo romano afianzando las ideas ya estudiadas; de este modo, comprenderán que lo importante no es dar la solución sino razonar jurídicamente consiguiendo, a través de debates en grupo y el trabajo personal, un conocimiento más profundo de las reglas e instituciones aplicables.

  18. Storytelling transmedia. Factores que influyen en la participación activa del usuario en campañas publicitarias basadas en estrategias de storytelling transmedia

    OpenAIRE

    Loizate Fondevila, Maite; Universitat Autònoma de Barcelona. Facultat de Ciències de la Comunicació

    2015-01-01

    Nos encontramos ante un nuevo modelo publicitario en el que los roles de quienes intervienen en el proceso comunicativo se han redefinido. Por un lado, las marcas, hasta hace poco absortas en sí mismas, se han visto obligadas a renunciar a su rol de “charlatanas” para empezar a escuchar al usuario y reconectarse con él. Por otro lado, la audiencia ha abandonado su pasividad de “oyente” para sumergirse en conversaciones proactivas con las marcas. En ese contexto de diálogo y, también, de conve...

  19. Negociação bilateral em mercados de energia eléctrica multi-agente com participação activa dos consumidores

    OpenAIRE

    Ilco, Cristina

    2012-01-01

    Nos últimos anos, o sector elétrico tem sofrido profundas alterações decorrentes do processo de reestruturação. Como consequência, surgiram diferentes estruturas de mercado, tais como em bolsa, contratos bilaterais e mistos, tendo como objectivo o aumento da competitividade. Nos mercados competitivos, os consumidores de electricidade podem escolher livremente os seus fornecedores de energia, em função de possíveis vantagens económicas e da qualidade do serviço. A comercialização de electricid...

  20. Geología de la margen activa del Perú entre los 3° y 12° de latitud sur

    Directory of Open Access Journals (Sweden)

    1990-01-01

    Full Text Available GEOLOGIE DE LA MARGE ACTIVE DU PEROU ENTRE 3° ET 12° DE LATITUDE SUD. La structure de la marge de type andin du Pérou est bien connue le long de trois profils sismiques multitraces localisés entre 5° et 12º Sud, au large de Paita (Profil CDP3, de Chimbote (CDP2 et Huacho (CDP1, du Nord vers le Sud. Des données additionnelles existent le long de ces transects il s'agit des levers SeaBEAM et SeaMARC II couvrant de vastes surfaces, de dragages et de carottages. Pendant le Leg. 112 du programme ODP, le Joides Resolution a foré 10 sites essentiellement localisés le long des profils CDP1 (679, 680, 681, 682 et 683 et CDP2 (683, 684 et 685. Les résultats du 'Nazca Plate Project' (1972-1980 ont montré que les roches métamorphiques du socle sud-américain s'étendent au moins jusqu'au bord du plateau continental et que l'accrétion de sédiments existe sur le bas de la pente continentale. Le retraitement postérieur des profils sismiques CDP1, CDP2 et CDP3 et les données bathymétriques SeaBEAM ont montré que la limite entre le socle continental de la marge et le prisme d'accrétion est localisé à la limite entre la pente moyenne et la pente inférieure de la marge. Cette limite marque également un changement dans le régime tectonique de la marge qui passe de l'extension pour le haut de pente à la compression vers le bas de pente. Les profils sismiques CDP1 et CDP2 montrent une discordance majeure de l'Eocène sur le socle identique à celle forée aux puits pétroliers Delphin et Ballena. Cette discordance est attribuée à la phase Incaïque (67 Ma à 57 Ma bien connue à terre. Pendant le Leg. 112, l'Eocène a été foré sur trois sites de la pente moyenne et du bas de pente de la marge. Au site 688, l'Eocène présente des faciès marins de faible profondeur d'eau appartenant au plateau continental et à la pente supérieure comme l'indiquent les foraminifères benthiques. Cet Eocène (57 Ma à 40 Ma est recouvert en discordance par de l'Oligocène supérieur. Les terrains de l'Eocène supérieur et de l'Oligocène inférieur (40 Ma à 25 Ma manquent. Cette discordance correspond à la dernière phase Incaïque qui est reconnue au travers de la marge depuis le plateau continental jusqu'à moins de 15 km de la fosse où on la trouve à plus de 6,2 km de profondeur sous le niveau de la mer. Ainsi, pendant les 25 derniers Ma, le taux minimum de subsidence de la marge continentale externe localisée au large de Huacho, a été de 250 m. Ma-1. La sédimentation des 25 derniers Ma est marquée par plusieurs discordances angulaires locales semblables à celles connues à terre. Elles correspondent aux phases Quechua 1 à 3 (18-19 Ma à Actuel. Aux sites 688 et 682 du bas de pente, la séquence du Pliocène inférieur présente des faciès finement laminés d'upwelling côtier qui se déposent aujourd'hui sous des profondeurs d'eau comprises entre 150 m et 500 m. Leur découverte indique une subsidence de la marge de 3,5 km à 4 km pendant les 5 à 6 derniers Ma. Cela correspond à un taux de subsidence de 675 m. Ma-1 comparable au taux de subsidence de 350 m. Ma-1 à 650 m. Ma-1 calculé sur le haut de pente à partir d'échantillons dragués dans le bassin de Lima. Les profils sismiques CDP1 et CDP2 montrent un complexe d'accrétion collé contre la zone de transition tectonique compression-extension. Au site 685 un hiatus de 4,3 Ma sépare les sédiments de pente non déformés du Pléistocène du Miocène terminal (6,1 Ma à 6,8 Ma sous-jacent. Les sédiments du Miocène présentent une fabrique pénétrative en compression. L'accrétion a commencé lorsque le flanc Nord de la ride de Nazca est passé en subduction à cet endroit, voilà environ 6 Ma. Au large de Paita, le long du profil CDP3, la bathymétrie SeaBEAM et les profils de sismique multitrace supplémentaires montrent des écroulements en masse sur le bas de pente. Deux escarpements courbes coupent la pente moyenne. Ils sont l'expression superficielle de surfaces de glissement vers le large le long desquels un bloc de 33 km par 20 km s'est déplacé de 800 m à 1000 m. Le raccordement de marqueurs indique en effet une rotation de 5° associé au glissement vers la fosse. Si ce mouvement est, comme nous le pensons, catastrophique, il aurait pu occasionner un tsunami de 50 m de haut, et cela pendant les 50 000 dernières années. L'effondrement des blocs localisés sur la pente moyenne a détruit une surface plate qui peut représenter le prolongement vers le bas du Tablazo connu à terre. Ce Tablazo est d'âge quaternaire au plus ancien. Ainsi la pente moyenne a pu subir une subsidence de 3 km pendant les deux derniers Ma avec un taux de 1500 m. Ma-1. Une estimation du volume de matériel érodé en provenance de la marge du Pérou peut être calculé à partir des valeurs de la subsidence reconnues le long des profils CDP1 et CDP3. Le long de CDP1 l'estimation du volume érodé pendant les 5 à 6 derniers Ma est de 450 km3 par km de fosse. Le long de CDP3 des valeurs moins fiables peuvent être calculées : 300 km3 par km de fosse pendant les 2 derniers Ma. Ces valeurs conduisent à des taux d'érosion compris entre 75 km3.km-1. Ma-1 et 150 km3, km-1. Ma-1 qui sont du même ordre de grandeur que ceux calculés le long de CDP1 par von Huene et al. (en préparation et qui sont de l'ordre de 345 km3 en utilisant le modèle du prime de Coulomb. La valeur inférieure du flux de matériel déplacé par érosion sous-crustale au Pérou est égale à peu de choses prés à la plus grande valeur du flux de sédiments subduits en provenance de la Plaque Nazca. La estructura tipo andino de la margen peruana se define por medio de tres registros sísmicos multicanales transversales, ubicados entre los 5 y 12 grados de Latitud Sur. De Norte a Sur son: mar adentro de Paita (CDP-3, de Chimbote (CDP-2 y de Huacho (CDP-1 respectivamente. Información adicional a lo largo de estas líneas, incluyen extensos levantamientos 'SeaBEAM' y 'SeaMARC II', dragado y muestreo de testigos. Durante la ODP 'Leg 112', la 'Joides Resolution' perforó en 10 sitios ubicados principalmente a lo largo de las líneas CDP-1 (679, 680, 681, 682 y 683 y CDP-2 (683, 684, y 685. Los resultados del 'Proyecto Placa de Nazca' (1972 - 1980 indicaron que las rocas metamórficas continentales se extendían por lo menos hasta el borde del zócalo y que los sedimentos han crecido a lo largo de la pendiente continental inferior. El reprocesamiento subsecuente de los records sísmicos multicanales CDP-1, CDP-2 y CDP-3 y el levantamiento batimétrico SeaBEAM, en las afueras de Paita y Chimbote, colocaron el límite entre el basamento continental y el complejo de crecimiento, a lo largo del borde entre la pendiente media e inferior. Este borde también marca un cambio en el régimen tectónico: de tensional hacia arriba, a compresional hacia abajo. Los registros sísmicos CDP-1 y CDP-2 muestran una discordancia en el basamento bajo la sección del Eoceno, similar a la perforada en los pozos industriales Delfín y Ballena. Se infiere que esta discordancia sea la primera discordancia Incaica documentada en la costa (67 a 57 Ma. Durante la actividad de Leg 112, la sección del Eoceno fue muestreada en tres lugares de la pendiente media e inferior de la margen. En la estación 688, el Eoceno contiene una fauna de foraminíferos propios de una secuencia marina de aguas someras. Esta secuencia eocénica (57 a 40 Ma está cortada por una discordancia a lo largo de la cual no existe el Eoceno Superior y el Oligoceno Inferior (40 a 25 Ma. La discordancia corresponde a la última discordancia Incaica, la cual se extiende desde el zócalo hasta dentro de 15 Km del eje de la Fosa y alcanza una profundidad de 6.2 Km bajo el nivel del mar. Durante los últimos 25 Ma, la mínima proporción de subsidencia de la margen continental externa fuera de Huacho, fue de 250 m. Ma-1. La sedimentación durante los últimos 25 Ma está marcada por varias discordancias angulares similares a las conocidas en la costa como Discordancias Quechua 1 a 3 (18-19 Ma a Recientes. En las estaciones 688 y 682 sobre la pendiente inferior, la secuencia basal pliocénica incluye facies de sedimentos finamente laminados, depositados por aguas frías que emergen de las profundidades y que están restringidas a la deposición en agua a profundidades de 150 a 500 m. Su recuperación indica 3.5 a 4.0 Km de subsidencia durante los últimos 5-6 Ma, lo cual corresponde a una proporción de subsidencia de 675 m. Ma-1. Esto es consistente con la proporción de subsidencia de 350 a 650 m. Ma-1 calculada de muestras dragadas pendiente arriba en la cuenca de Lima. Los records sísmicos CDP-1 y CDP-2 reflejan una cuña de crecimiento sobre la zona de transición. En el punto 685, un hiato de por lo menos 4.3 Ma separa la pendiente de los sedimentos Pleistocénicos no deformados de los sedimentos subyacentes del Mioceno Tardío (6.1 a 6.8 Ma que han crecido por la adición externa de partículas, las cuales exhiben una estructura compresional pervasiva. El crecimiento comenzó con la subducción del borde posterior de la Dorsal de Nazca hace 6 Ma. A lo largo del registro CDP-3 en las afueras de Paita, los registros de batimetría SeaBEAM y los adicionales de reflexión sísmica, revelan una fuerte denudación en forma de una avalancha de desmonte en la pendiente inferior. Dos escarpas curvadas, cortan la pendiente media y marcan superficies de deslizamiento hacia el mar. Un block de 20 por 33 Km fue desplazado de 800 a 1000 m y rotado 5 grados hacia atrás durante su movimiento hacia abajo. Si este deslizamiento fue tan catastrófico como lo fue la avalancha de desmonte documentada hacia abajo, se debe haber generado un tsunami local de 50 m de alto durante los últimos 50,000 años. El fallamiento en bloques del área de la pendiente media destruyó una superficie plana y suave conocida en la costa como el 'Tablazo' de edad Cuaternaria. El área de la pendiente media a lo largo de la línea CDP-3, puede haber tenido una subsidencia de hasta 3 Km durante los últimos 2 Ma, a una proporción de 1500 m. Ma.-l. El volumen del material erosionado de la margen peruana puede ser deducido por la subsidencia a lo largo de CDP-1 y CDP-3. La erosión estimada durante los últimos 5-6 Ma, es de 450 Km3 por Km a lo largo de la fosa en CDP-1. Un valor más especulativo de la erosión durante los últimos 2 Ma, es de 300 Km3 por Km a lo largo de la Fosa en CDP-3. Esto produce proporciones de erosión entre 75 y 150 Km3.Km-l.Ma-l, consistente con los 345 a 535 Km3 calculados en la línea CDP-1 por von Huene et al. (en preparación, usando el modelo de la Cuña de Coulomb. El valor más bajo de flujo de material removido por erosión subcortical iguala más o menos al valor del flujo más grande de sedimentos que vienen de la Placa de Nazca. THE GEOLOGY OF THE PERU ACTIVE MARGIN BETWEEN 3 AND 12° SOUTH LATITUDE. The structure of the Andean type Peruvian margin is defined along three transverse multichannel seismic records located between 5° ans 12° S offshore Paita (CDP3, Chimbote (CDP2 and Huacho (CDP1 from north to south. Additional data along these transects include extensive SeaBEAM and SeaMARC II surveys, dredging, and core sampling. During ODP Leg 112 the Joides Resolution drilled at 10 sites located mainly along CDP1 (679, 680, 681, 682 and 683 and CDP2 (683, 684 and 685 transects. Results of the 'Nazca Plate Project' (1972-1980 indicated that continental metamorphic rocks extend at least to the edge of the shelf and that sediment had accreted along the lower continental slope. The subsequent reprocessing of the CDP1, CDP2 and CDP3 multichannel seismic records and the bathymetric SeaBEAM survey off Paita and Chimbote placed the boundary between continental basement and the accretionary complex along the middle slope-lower slope boundary. This boundary also marks a change in the tectonic regime from tensional upslope to compressional downslope. Seismic records CDP1 and CDP2 show an unconformity on basement below the Eocene section similar to that drilled at the Delphin and Ballena industry wells. The unconformity is inferred to be the first Incaic unconformity (67 to 57 Ma documented onshore. During Leg 112, the Eocene section was sampled at three sites on the middle and lower slopes of the margin. At site 688, the Eocene contains a shallow marine sequence with shelf and upper slope benthic-foraminifera. This Eocene sequence (57 to 40 Ma is cut by an unconformity along which the uppermost Eocene and Lower Oligocene (40 to 25 Ma is missing. The unconformity corresponds to the last Incaic unconformity, which extends seaward from the shelf to within 15 km of the trench axis and reaches a depth of 6.2 km below sea level. During the past 25 Ma, the minimum rate of subsidence of the outer continental margin off Huacho was 250 m. Ma-1. The sedimentation of the past 25 Ma is marked by several local angular unconformities similar to that know onshore as Quechua 1 to 3 unconformities (18-19 Ma to Recent. At sites 688 and 682 on the lower slope, the basal Pliocene sequence includes finely laminated coastal upwelling facies, which are restricted to deposition in water 150 to 500 m deep. Their recovery indicates 3.5 to 4 km of subsidence during the past 5-6 Ma, which corresponds to a subsidence rate of 675 m Ma-1. This is consistent with the subsidence rate of 350 to 650 m Ma-1 calculated from samples dredged upslope in the Lima basin. Seismic records CDP1 and CDP2 image and accretionary wedge stacked against the transition zone. At site 685, a hiatus of at least 4.3 Ma separates the undeformed Pleistocene slope sediment from the underlying late Miocene (6.1 to 6.8 Ma accreted sediment that exhibits a pervasive compressional fabric. The accretionary began with the subduction to the trailing edge of the Nazca Ridge 6 Ma ago. Along records CDP3 off Paita, SeaBEAM bathymetry and additional seismic reflection records reveal mass wasting in the form of avalanche debris on the lower slope. Two curved scarps cut the middle slope and mark slip surfaces seaward of which a 20 km by 33 km block was displaced 800 to 1000 m and back rotated 5° as it moved downslope. If this slip was catastrophic as was the avalanche debris documented downslope, a local 50 m high tsunami was generated during the past 50,000 yr. Block faulting of the middle slope area destroyed a smooth flat surface that may represent a seaward extension of a flat structure known onshore as the Tablazo. The Tablazo is of Quaternary age. The middle slope area along the CDP3 line may have subsided as much as 3 km during the past 2 Ma at a rate of 1,500 m.Ma-1. Estimates of the volume of material eroded from the Peru margin can be derived from the amount of subsidence along CDP1 and CDP3. Along CDP1 the estimated erosion during the past 5-6 Ma is 450 km3 per km along trench. Along CDP3, a more speculative value of erosion during the past 2 Ma is 300 km3 per km along trench. This yields rates of erosion-between 75 and 150 km3, km-1 Ma-1 consistent with the 345 to 535 km3 calculated along the CDP1 line by von Huene el al. (in preparation using the Coulomb wedge model. The lowest flux value of material removed by subcrustal erosion equal more or less the greatest flux value of sediment coming from the Nazca Plate.

  1. Replegamiento de láminas de corrimiento epidérmicas mediante fallas inversas de basamento activas en la Precordillera Oriental del oeste de Argentina

    OpenAIRE

    Meigs, A.; Krugh, W. C.; Schiffman, C.; Vergés, Jaume; Ramos, V. A.

    2006-01-01

    Devastating earthquakes like the 1944 San Juan earthquake reflect active deformation in western Argentina. Although the earthquake caused considerable damage to San Juan, the source of the earthquake remains uncertain. Potential source faults occur in the thin-skinned fold-and-thrust belt Precordillera province and in the thick-skinned Sierras Pampeanas province, to the west and east, respectively of Sierra de Villicum, a thrust sheet in the eastern Precordillera northwest of San Juan. Sierra...

  2. EVALUACIÓN DE PROPIEDADES MECÁNICAS, ÓPTICAS Y DE BARRERA ENPELÍCULAS ACTIVAS DE ALMIDÓN DE YUCA

    OpenAIRE

    JOSÉ FELIPE CORTÉS; AMANDA LUCÍA FERNÁNDEZ; SILVIO ANDRÉS MOSQUERA; REINALDO VELASCO

    2014-01-01

    Películas obtenidas a partir de almidón de yuca de la variedad CM 7138 -7, nativo y modificado por hidroxipropilación, fueron sometidas a evaluaciones mecánicas, ópticas y de barrera, durante periodos de tiempo de 0, 30, 60, 90 y 120 días determinando el efecto del tiempo de almacenamiento sobre la modificación química realizada. Las películas fueron obtenidas por extrusión soplado por medio de un extrusor de tornillo simple. El material se obtuvo en tres etapas: la primera etapa fue la produ...

  3. La transición a la vida activa de las personas con discapacidad: expectativas familiares y grado de ajuste al trabajo

    Directory of Open Access Journals (Sweden)

    Ana Riaño-Galán

    2014-06-01

    Full Text Available as pessoas com deficiência física ou mental têm direito a ser inseridas no mercado de trabalho para exercer seu papel como cidadãos ativos, independentes e com um nível de qualidade de vida adequado, o que constitui um autêntico desafio ao qual devemos responder. No caso deste estudo, nos limitamos ao tema deficiência intelectual. No que diz respeito ao âmbito educativo, os Programas de Qualificação Profissional Inicial (PCPI, na modalidade de Aula de Formação Específica, oferecem una formação adequada ao patamar de competências sociais, pessoais e laborais para este coletivo. Neste trabalho, apresentamos os resultados da aplicação de um Itinerário de Inserção Laboral, dentro do quadro de um projeto europeu, no qual participaram estudantes de três centros educativos da Finlândia, Espanha e Dinamarca, assim como as suas respetivas famílias. Para conhecer o grau de ajustamento ao trabalho destes jovens, estes responderam ao Work Adjustment Inventory-WAI (Inventário de Ajustamento ao Trabalho e também entrevistamos as suas famílias. Os resultados permitiram saber que o itinerário de inserção laboral desenhado constitui uma oferta formativa adequada para os estudantes em questão, enfatizamos que o grau de adaptabilidade ao trabalho está relacionado com o nível de atividade, empatia, sociabilidade e assertividade de cada pessoa. As entrevistas possibilitaram a identificação do perfil das famílias destes estudantes e identificar as suas expectativas em relação ao futuro dos seus filhos e filhas. Entre as conclusões alcançadas, destacam-se as altas expectativas das famílias no que diz respeito à inserção dos seus filhos, assim como o alto nível de avaliação relativamente ao itinerário desenhado como estratégia fundamental para conseguir lograr uma formação integral e uma inserção sócio-laboral adequada.

  4. La memoria como búsqueda activa: la transmisión intergeneracional de la experiencia militante en el filme documental Seré millones

    Directory of Open Access Journals (Sweden)

    Mariana Paganini

    2017-06-01

    de Paul Ricoeur, porque el recuerdo es el resultado de una reconstrucción laboriosa que produce una movilización tanto intelectual como afectiva en los sujetos y, a la vez, crea un lazo entre generaciones. Por último, se examina la relación de la película con el cine militante argentino de las décadas de los sesenta y setenta, al problematizar el vínculo entre la intencionalidad de los realizadores y la recepción por parte de los espectadores.

  5. EVALUACIÓN DE PROPIEDADES MECÁNICAS, ÓPTICAS Y DE BARRERA ENPELÍCULAS ACTIVAS DE ALMIDÓN DE YUCA

    Directory of Open Access Journals (Sweden)

    JOSÉ FELIPE CORTÉS

    2014-06-01

    Full Text Available Películas obtenidas a partir de almidón de yuca de la variedad CM 7138 -7, nativo y modificado por hidroxipropilación, fueron sometidas a evaluaciones mecánicas, ópticas y de barrera, durante periodos de tiempo de 0, 30, 60, 90 y 120 días determinando el efecto del tiempo de almacenamiento sobre la modificación química realizada. Las películas fueron obtenidas por extrusión soplado por medio de un extrusor de tornillo simple. El material se obtuvo en tres etapas: la primera etapa fue la producción de Almidón Termoplástico (TPS con 75% de almidón, 24,5% de glicerol y 0,5% de capsaicina; en la segunda etapa, se realizó la Mezcla Binaria (MB con 68,63% de Ácido Poliláctico (PLA, 29,41% de Policaprolactona (PCL, 1,96% de anhídrido maleico y 1% de colorante y, por último se realizó la extrusión soplado de la mezcla ternaria, compuesta por 75% de TPS y 25% MB. Los cambios de algunas propiedades con respecto al tiempo, fueron más evidentes en las películas a base de almidón nativo presentando una diferencia significativa, debido al proceso de retrogradación y posiblemente a que no se formó una fase homogénea en el material y por lo tanto los componentes se distribuyeron en fases distintas y separadas.

  6. Influencia de los iones Ba2+ y Sr2+ en el proceso de hidratación del cemento portland y de los cementos con adiciones activas

    OpenAIRE

    Živanović, B. M.; Petrašinović, Lj.; Milovanović, T.; Karanović, Lj.; Krstanović, I.

    1987-01-01

    En el presente trabajo se estudia la influencia de la concentración de los iones Sr2+ y Ba2+ en las aguas de amasado sobre el proceso de hidratación de varios cementos portland y de adición. Se comprueba un incremento de las resistencias mecánicas de dichos cementos, a los 28 días, cuando aumenta la concentración de los iones Ba2+ y Sr2+ en las aguas de amasado, lo cual sugiere una posible explicación microestructural a dicho fenómeno.

  7. La evaluación participativa de un programa de formación para una participación activa e intercultural

    OpenAIRE

    Folgueiras, Pilar

    2007-01-01

    This article starts of the theoretical and methodological basis fundamental to the elaboration, application and evaluation of a training program for active and intercultural participation specifically designed for women. The programme is based in the participatory evaluation methodology, which allows the participation of the research subjetcs in the entire process of the evaluation.We present the participative evaluation model: diagnostic evaluation that includes an examination of the project...

  8. Estudio comparativo entre un programa de Escuela de Espalda y Ejercicios Hipopresivos realizados en las pausas activas en trabajadores de oficina

    OpenAIRE

    Tersa Miralles, Carlos

    2017-01-01

    Pregunta Clínica: ¿Es el uso de Ejercicios Hipopresivos más beneficioso que un protocolo de escuela de espalda para prevenir o reducir el dolor lumbar y sus aspectos psicosociales en trabajadores de oficina en posición de sedestación mantenida? Objetivo: Comparar si un programa de Ejercicios Hipopresivos es más efectivo que un programa de Escuela de Espalda para trabajadores en posición de sedestación mantenida. Metodología: Se realizará un estudio experimental mediante un ensayo clínico cont...

  9. Validez, fiabilidad y reproducibilidad de un test incremental en rampa en personas físicamente activas. Validity and reliability of an incremental ramp test for active persons.

    Directory of Open Access Journals (Sweden)

    Benito Peinado, Pedro José

    2005-10-01

    Full Text Available ResumenLa novedosa aparición de equipos de análisis de gases más sofisticados y precisos, obliga a los investigadores, como paso inicial de cualquier estudio más complejo, a la calibración y contraste de sus herramientas de medida. En el momento de comenzar este estudio los datos publicados prueban sin lugar a dudas la validez del equipo de análisis de gases Oxicon Pro ® (Carter y col., 1999:49, Rietjens y col., 2001, Koskolou y Geladas, 2002, pero no ha sido probada la reproducibilidad de las pruebas con este equipo y el protocolo que aquí proponemos. Con este fin se realizaron pruebas test-retest a un grupo de sujetos físicamente activos (Estudiantes de Educación Física el INEF de Madrid. Se estudiaron 10 sujetos físicamente activos, (características en tabla I a los que se realizó dos pruebas de esfuerzo en cicloergómetro. El protocolo en rampa, aumentaba 5 vatios cada 12 segundos (25 vatios·min- 1 con un calentamiento de 3 minutos se aplicaba hasta que se cumplió, al menos dos de los criterios habituales para el cese de la prueba. Los resultados (tablas IV a VIII nos indican la alta correlación entre las variables en las dos pruebas realizadasoscilando entre r = 0,60 y r = 0,99 y coeficiente de determinación para el VO2, VCO2 y la Carga que fueron de r2 = 0,95 0,94 y 0,97 respectivamente. Solo en dos variables se encontraron diferencias significativas entre la prueba 1 y 2. Esto fue en la producción máxima de VCO2 y en el umbral aeróbico expresado en frecuencia cardiaca. Estas diferencias pueden ser debidas a la mayor carga desarrollada en la 2ª prueba, aunque estas no sean significativas. No se encontraron correlaciones entre variables de rendimiento como VO2 máx. , VO2/kg; W y W/kg y las variables de recuperación. En conclusión, las variables estudiadas nos ofrecen bastante fiabilidad sobre el protocolo y equipo utilizados en nuestro estudio. Con esto queda probada la fiabilidad y reproducibilidad del test, la validez alcanzada es de contenido y queda justificada por su inclusión habitual en la determinación de los umbrales en ejercicio en la bibliografía (Yamamoto y col., 1991, Ribas y col., 1994, Chicharro y col., 1995, Lucia y col., 1999.AbstractThe continuous apparition of new gas analysis equipment makes necessary and accurate calibration at the start of any new research. At the start of this study the validity of the Oxicon Pro ® analyser had already been proved (Carter et al. 1999:49, Koskolou y Geladas, 2002, Rietjens et al., 2001, but not the reproducibility of it with the protocol here proposed. With this aim test-retest trials were carried out with a group of subjects’ physically active (Sport Science students from the INEF of Madrid. Ten subjects participate (5 males and 5 females physically active (table I sows the characteristics of the subjects did two effort tests in cicloergometer. The ramp protocol increased 5 Watts every 12 seconds (25 watts•min-1, with a 3 minute worm up and lasting when the normal criteria of maximal effort were shown.The results (Table IV to VIII show the high correlation between the variables of the two tests carried out (from r=0.60 and 0.99 and a determination coefficient for VO2, VCO2 and Load of r2=0.95, 0.94 and 0.97 respectively. Only two variables showed differences between test 1 and 2, the maximal production of VCO2 and the aerobic threshold expressed in hart rate. These differences could be done to the increased load of the second test even thought no significant differences were observed on that parameter. No correlations were observed between performance variables like VO2 max, VO2/kg, Load and Load/kg and the recuperation variables.In conclusion, the studied variables support the validity of the protocol and the analyser used on our future researches.

  10. Anal and Rectal Disorders

    Science.gov (United States)

    ... Abscess Anorectal Fistula Foreign Objects in the Rectum Hemorrhoids Levator Syndrome Pilonidal Disease Proctitis Rectal Prolapse The ... cancer Foreign objects in the anus and rectum Hemorrhoids Levator syndrome Pilonidal disease Proctitis Rectal prolapse Diagnosis ...

  11. Foreign Objects in the Rectum

    Science.gov (United States)

    ... Abscess Anorectal Fistula Foreign Objects in the Rectum Hemorrhoids Levator Syndrome Pilonidal Disease Proctitis Rectal Prolapse (See ... Abscess Anorectal Fistula Foreign Objects in the Rectum Hemorrhoids Levator Syndrome Pilonidal Disease Proctitis Rectal Prolapse NOTE: ...

  12. Sintomas somáticos de depressão em pacientes portadores de retocolite ulcerativa idiopática Síntomas somáticos de depresión en pacientes con rectocolitis ulcerosa idiopática Somatic symptoms of depression in patients with idiopathic ulcerative colitis

    Directory of Open Access Journals (Sweden)

    Taís de Souza Serafim

    2009-06-01

    Full Text Available OBJETIVO: Identificar os sintomas depressivos mais freqüentes entre portadores da doença Retocolite Ulcerativa Idiopática (RCUI e compará-los a um grupo de controle. MÉTODO: A amostra compôs-se de 100 indivíduos adultos portadores de RCUI que freqüentavam o Ambulatório de Doenças Inflamatórias do Cólon do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo que foram comparados a 100 indivíduos isentos da doença. Após os procedimentos éticos devidos todos responderam ao Inventário de Depressão de Beck. RESULTADOS: Dos 21 sintomas depressivos, seis mostraram valores estatísticos significativos para: distorção da imagem corporal, inibição para o trabalho, fadiga, perda do apetite, preocupação somática e diminuição de libido. CONCLUSÃO: Verificou-se que os doentes apresentaram com mais freqüência sintomas depressivos da esfera somática quando comparados ao grupo de controle. A similaridade dos sintomas entre a doença e os sintomas depressivos faz com que os doentes sejam freqüentemente subdiagnosticados.OBJETIVO: Identificar los síntomas depresivos más frecuentes entre portadores de la enfermedad Rectocolitis Ulcerativa Idiopática (RCUI y compararla a un grupo de control. MÉTODO: La muestra estuvo compuesta de 100 individuos adultos portadores de RCUI que frecuentaban El Consultorio Externo de Enfermedades Inflamatorias del Colon del Hospital de las Clínicas de la Facultad de Medicina de la Universidad de Sao Paulo que fueron comparados con 100 individuos libres de la enfermedad. Después de los respectivos procedimientos éticos todos respondieron al Inventario de Depresión de Beck. RESULTADOS: De los 21 síntomas depresivos, seis mostraron valores estadísticos significativos para: distorsión de la imagen corporal, inhibición para el trabajo, fatiga, pérdida del apetito, preocupación somática y disminución de la libido. CONCLUSIÓN: Se verificó que los enfermos presentaron con más frecuencia síntomas depresivos de la esfera somática cuando fueron comparados con el grupo control. La similitud de los síntomas entre la enfermedad y los síntomas depresivos hace que los enfermos sean frecuentemente subdiagnosticados.OBJECTIVE: To identify the most common symptoms of depression in patients with idiopathic Ulcerative Colitis (UC and to compare these symptoms of depression with those in patients without UC. METHOD: The sample consisted of 100 adults with Ulcerative Colitis attending the outpatient clinic for Inflammatory Bowel Diseases of the "Hospital das Clinicas" of the School of Medicine of the University of São Paulo, who were compared with 100 individuals without the disease. Following ethical procedures, each participant answered to the Beck Depression Inventory. RESULTS: Of the 21 symptoms of depression, six were statistically significant for distortion of body image, inability for work, fatigue, loss of appetite, somatic concerns, and decreased libido. CONCLUSIONS: Patients with UC had more somatic symptoms of depression than patients in the control group. Similarity of symptoms of UC with those of depression leads to under diagnosing patients with UC.

  13. Omega 3 fatty acids supplementation has an ameliorative effect in experimental ulcerative colitis despite increased colonic neutrophil infiltration Los suplementos de ácidos grasos omega 3 tienen efectos beneficiosos en colitis ulcerosa a pesar del aumento de la infiltracción por neutrófilos del colon

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    Ioannis Varnalidis

    2011-10-01

    Full Text Available Purpose: omega 3 polyunsaturated fatty acids have anti-inflammatory properties and can be beneficial in the treatment of inflammatory diseases, such as ulcerative colitis. Dextran sodium sulphate (DSS colitis in rats appears to mimic nearly all of the morphological characteristics and lesion distributions of ulcerative colitis. The purpose of the current study was to investigate the efficacy of omega 3 fatty acids in the treatment of experimental ulcerative colitis. Methods: thirty-six Wistar rats were randomly assigned to group A or group B receiving 5% dextran sulfate sodium (DSS in their drinking water for eight days. For the next eight days post-DSS, group A animals received tap-water, and group B animals were fed a nutritional solution containing high levels of omega 3 polyunsaturated fatty acids (ProSure®, Abbott Laboratories, Zwolle, Netherlands once per day, administrated with a orogastric feeding tube. Results: animals fed an omega 3 rich diet exhibited a statistically significant increase in hematocrit and hemoglobin levels, compared to animals drinking tap water, and a trend towards histopathological and clinical improvement, with the administration of omega 3 fatty acids ameliorating epithelial erosion by day 8 post-DSS, but no statistically significant difference was observed between group A and group B animals at 4 or 8 days post-DSS. Also, a statistically significant increase in neutrophil infiltration was observed, as depicted by myelohyperoxidase activity. Conclusion: our findings support a positive role of omega 3 polyunsaturated fatty acids supplementation in an experimental model of ulcerative colitis despite the increased colonic neutrophil infiltration. Further studies are needed in order to investigate the role of increased neutrophils in colonic mucosa.

  14. Falla activa de Quito y fuentes sismogenéticas regionales: un estudio del riesgo sísmico de Quito (Ecuador con el análisis de los sedimentos cuaternarios

    Directory of Open Access Journals (Sweden)

    1996-01-01

    Full Text Available FAILLE ACTIVE DE QUITO ET SOURCES SISMOGENETIQUES REGIONALES: UNE ETUDE DE L’ALEA SISMIQUE DE QUITO (EQUATEUR PAR L’ANALYSE DES SEDIMENTS QUATERNAIRES. De nombreux événements sismiques ont été décrits au cours des 460 ans d’histoire écrite de la ville, ils atteignent une valeur IX sur l’échelle d’intensité (MSK. Parmi les diverses sources sismogènes susceptibles d’affecter sensiblement la capitale, on considère la faille de Quito capable de produire des intensités supérieures à VIII. Elle se caractérise comme la source potentiellement la plus dangereuse pour la ville. Dans le registre historique, son activité fut possiblement identifiée en 1755, produisant alors une intensité de VIII-IX (MSK dans Quito. Afin de connaître la vitesse de cette faille et la récurrence des événements majeurs (laquelle est supérieure à la durée de l’enregistrement historique, il a été nécessaire d’étudier la séquence géologique quaternaire. La paléosismicité a été mise en évidence grâce à l’observation de niveaux de paléoliquéfaction enregistrés dans les sédiments. Durant l’analyse des sédiments holocènes de la partie basse de la ville, des témoins de l’activité sismique régionale ont été observés, de même que des indices d’activité de la faille de Quito sous la forme de failles synsédimentaires et de déformations sismotectoniques. Un enregistrement paléosismique relativement complet a été rencontré dans le bassin nord de la ville, notamment dans l’affleurement de la “Calle Pinzón” où une vingtaine de niveaux paléosismiques ont été mis en évidence sous la forme de couches contournées de type invaginations. Ces figures sont produites en fond de lac, à l’interface entre eau et sédiments. En comparant ces niveaux avec des exemples de la littérature, les relations définies entre accélération horizontale et intensité sismique (log aH = 0.014 + 0.30IMM et la distribution des intensités dans la sismicité historique, il a été proposé une échelle de détermination de paléointensités sismiques d’après l’intensité de la déformation par liquéfaction. La répartition des intensités >VI (MM/MSK définies par cette échelle montre une bonne cohérence avec la distribution des intensités définies par la sismicité historique. L’utilisation de la sismicité historique et de la paléosismicité géologique définit une récurrence moyenne de 115 ans pour les événements majeurs d’intensité >VII. Il faut noter ici que le dernier événement correspondant à cet intervalle d’intensités est survenu en 1868, il y a plus de 125 ans, mais également que, au cours des 460 ans d’histoire, il a été observé des intervalles de récurrence allant de 168 ans à seulement 9 ans. L’utilisation de l’échelle citée ci-dessus a également permis de mettre en évidence la probable ocurrence d’un séisme d’intensité IX-X (MM/MSK entre le Xème et le XVIème siècle. Dans la ville, plusieurs niveaux paléosismiques ont pu être corrélés avec cet événement grâce à la présence d’un banc repère d’origine volcanique déformé par ce séisme. Ces niveaux ont pu également être corrélés dans le bassin avec des déformations sismotectoniques, faisant ainsi de la faille de Quito le candidat le plus probable pour expliquer une telle intensité dépassant le maximum historique de près d’un degré d’intensité. A lo largo de los 460 años de historia escrita que tiene la ciudad de Quito, se han registrado varios eventos sísmicos que alcanzaron intensidades de hasta IX grados en la escala MSK. Dentro de las numerosas fuentes sismogenéticas que pueden generar daños en la ciudad, se identifica la falla de Quito, cuya actividad es susceptible de producir intensidades superiores a VIII grados, haciendo de ella una fuente de alto peligro para la ciudad. En el registro histórico, se atribuye al sismo de 1755 como producido por la actividad de esta falla, el mismo que reportó intensidades de VIII-IX (MSK en Quito. A fin de conocer la velocidad de esta falla y la recurrencia de los eventos mayores, que seguramente sobrepasan los 500 años de sismicidad histórica, se tuvo que recurrir al análisis del registro geológico. La paleosismicidad se ha definido mediante el análisis de las evidencias de paleolicuefacción producida por los terremotos que afectaron a los sedimentos holocénicos de la parte baja de la ciudad. Durante el análisis de estos sedimentos, se encontraron manifestaciones de la paleosismicidad debida tanto a la actividad de las fuentes regionales, como también a la actividad de la falla de Quito, que se manifestaron bajo la forma de estructuras de licuefacción, algunas fallas sinsedimentarias y deformaciones sismotectónicas. Un registro paleosísmico relativamente completo se encontró en la cuenca norte, en el afloramiento en la Calle Pinzón, donde se reconocieron unos veinte niveles de paleolicuefacción mostrándose principalmente como capas contorneadas o invaginaciones, que se producen en el fondo de los lagos en la interfase agua-sedimento. Comparando estos niveles deformados con los ejemplos de la literatura, con las relaciones entre aceleración horizontal obtenidas en función de la intensidad (log aH = 0.014 + 0.30IMM y con la distribución de la sismicidad histórica, se propone una escala de intensidades sísmicas deducidas de la intensidad de la deformación provocada por la licuefacción. La distribución de las intensidades definidas con esta escala muestra una buena coherencia con la distribución de intensidades del registro histórico para valores de intensidad > VI (MM/MSK. El uso de la sismicidad histórica y de la paleosismicidad geológica define una recurrencia media de 115 años para los eventos que superan una intensidad de VII. Hay que notar que el último evento sísmico relacionado con este rango de intensidad ocurrió en 1868, hace más de 125 años pero hay que considerar que en los 460 años de historia, el tiempo transcurrido entre eventos puede variar entre 9 y 168 años para tales eventos. El uso de la escala anteriormente descrita permitió proponer también la ocurrencia de un terremoto de intensidad IX-X (MM/MSK entre el siglo X y el siglo XVI. Este nivel pudo ser correlacionado en algunos lugares de la cuenca gracias a la presencia de una capa guía de origen volcánico afectada por esta deformación. Por otra parte, se puede correlacionar este evento con deformaciones sismotectónicas en la cuenca, haciendo de la falla de Quito el candidato más probable para explicar esta intensidad que supera al máximo histórico en casi un grado de intensidad. QUITO ACTIVE FAULT AND REGIONAL SEISMOGENIC SOURCES: A SEISMIC HAZARD STUDY FOR QUITO (ECUADOR INFERRED FROM QUATERNARY SEDIMENTS ANALYSIS. Over the 460 years of Ecuadorian written history, several seismic events were registered, some of them reaching intensity IX (MSK in Quito. From the various seismogenic sources able to produce damage in the city, the Quito Fault is thought to be able to produce higher intensities in case of a rupture of the fault along its entire length (45 Km, making this structure the potentially more dangerous seismogenic source for the city. In the historical record, activity of this fault was only registered once in 1755, when part of this fault ruptured producing intensity VIII-IX (MSK in Quito. In order to know the slip rate and the recurrence of the major events, which surely extend beyond the five hundred years of seismic history, it was necessary to make use of the geologic record. The paleoseismicity was defined by means of the analysis of earthquake-induced paleoliquefaction horizons produced in a lacustrine environment. Evidences of the regional seismic activity were observed during the analysis of the Holocene sediments from the lower part of Quito, as well as evidences of the Quito fault activity such as synsedimentary faults and seismotectonic deformation. A relatively complete paleoseismic record was observed in the northern basin, where a particular exposure in the “Calle Pinzón” shows the succession of at least 20 earthquake-induced contorted bedding horizons. These paleoseismic features occur at the bottom of lakes, at the water - sediments interface. From the comparison between published examples, relations between horizontal ground acceleration and intensity (log aH = 0.014 + 0.30IMM and intensity distribution inferred from the historical seismicity, we propose to define a scale of paleointensity according to the intensity of the earthquake-induced deformation. The obtained intensity distribution for intensities >VI (MM/MSK shows a good coherence with the intensity distribution inferred from the historical seismicity. Both the historical seismicity and geological paleoseismicity indicate an average recurrence of 115 yr. for major events with intensities >VII. We must notice that the last seismic event corresponding to this intensity range occurred in 1868, more than 125 years ago, but also that, within the 460 years of historical seismicity, this recurrence varied from 168 to just 9 years. The use of the above mentioned scale also permit to evidence the probable occurrence of a major event of intensity IX-X (MM/MSK between the 10th and the 16th century. Several paleoseismic horizons were successfully correlated with this event thanks to the presence of a volcanic key bed deformed by this paleoseismic shaking. These horizons were also correlated with seismotectonic deformation in the basin, making the Quito fault the most probable seismic source able to explain this major intensity overpassing the historical maximum intensity by almost one degree.

  15. Las audiencias activas en la regulación de los medios: la dialéctica consumidor-ciudadano en España y México

    Directory of Open Access Journals (Sweden)

    Carmen Fuente Cobo

    2014-07-01

    Full Text Available Dos han sido los prismas bajo los que se ha concebido tradicionalmente a la audiencia: como ciudadanos, que ante los mensajes de los medios ejercen sus derechos comunicativos y participan en la construcción de una opinión pública libre; o como consumidores o usuarios, que actúan dentro de un mercado de productos audiovisuales. Mientras que la primera perspectiva atiende a la comunicación audiovisual valorando su interés público y su influencia en la construcción de un espacio público de debate y discusión, la segunda atiende a la dimensión más privada e individual de la comunicación audiovisual. En el presente trabajo se abordan las principales posiciones doctrinales sobre dicha dicotomía consumidor-ciudadano, analizando para ello la obra de los autores que más atención han dedicado a estas cuestiones en el ámbito europeo, y en especial los trabajos de Peter Dahlgren sobre las relaciones entre medios y democracia, los de Richard Collins sobre política audiovisual, y los vinculados a Sonia Livingstone sobre esfera pública, participación de las audiencias y gobernanza de los medios. Realizada esta aproximación teórica, se analiza la presencia de dichas concepciones de la audiencia en dos ordenamientos jurídicos audiovisuales que están experimentando modificaciones sustanciales: el español y el mexicano. Como conclusión, se constata que las distintas concepciones de la audiencia están en profunda relación con la forma de concebir el control de los medios y la rendición de cuentas de sus operadores frente al público.

  16. Relaciones y definiciones de pertenencia en los conjuntos oficialistas o bases de sustentación activa de Lula (2002-2006) y Kirchner (2003-2007): principales argumentos

    OpenAIRE

    Rocca Rivarola, Dolores

    2013-01-01

    [es] A partir de un marco conceptual que postula un escenario político-electoral marcado por identidades políticas fluctuantes y transformaciones en los partidos políticos, este trabajo presenta distintos argumentos acerca de las definiciones de pertenencia, las dinámicas internas y las relaciones mutuas y con el gobierno que establecían distintas organizaciones integradas dentro de dos conjuntos oficialistas: los...

  17. Relaciones y definiciones de pertenencia en los conjuntos oficialistas o bases de sustentación activa de Lula (2002-2006) y Kirchner (2003-2007): Principales argumentos

    OpenAIRE

    Rocca Rivarola, Dolores

    2013-01-01

    A partir de un marco conceptual que postula un escenario político-electoral marcado por identidades políticas fluctuantes y transformaciones en los partidos políticos, este trabajo presenta distintos argumentos acerca de las definiciones de pertenencia, las dinámicas internas y las relaciones mutuas y con el gobierno que establecían distintas organizaciones integradas dentro de dos conjuntos oficialistas: los formados en torno a los presidentes Néstor Kirchner (2003-2007) y Luiz Inácio Lula D...

  18. Metodologías activas. Un estudio de AICLE/CLIL en Tecnología e Inglés / Active Learning. A study of CLIC/AICLE in Technology and English

    Directory of Open Access Journals (Sweden)

    Susana Warburton

    2017-09-01

    Full Text Available Resumen: Esta investigación recoge el trabajo realizado durante un periodo de dos cursos académicos en un centro concertado de la Comunidad valenciana, dentro de la metodología Aprendizaje Integrado de Contenidos y Lenguas Extranjeras (AICLE o en inglés Content and Language Integrated Learning (CLIL. Las materias implicadas en esta investigación han sido la de tecnología y lengua inglesa del segundo ciclo de Educación Secundaria Obligatoria. Se parte de la hipótesis de que los alumnos no se encuentran muy receptivos para el aprendizaje de lenguas extranjeras y que nuevos enfoques metodológicos, en particular el aprendizaje cooperativo a través de AICLE/CLIL, podrían motivar y mejorar los resultados de aprendizaje del inglés, así como el de otras materias. Para la obtención de datos hemos utilizado cuestionarios, entrevistas, observación participativa durante la realización de las diferentes tareas y las exposiciones orales de los trabajos y observadores externos. Los resultados evidencian que la integración de contenidos y lengua ha mejorado sensiblemente en las comunicaciones orales de los alumnos. Un estudio comparativo con otras asignaturas menos prácticas, podría ampliar este trabajo. Abstract: This research includes the work done over a period of two years at a private centre of Valencia, within the methodology Content and Language Integrated Learning (CLIL. The areas involved in this project have been Technology and the English language of the second cycle of secondary school. The assumption is that students are not very receptive to foreign language learning and new methodological approaches, including cooperative learning through CLIL, could motivate and improve learning outcomes of English and those of other subjects. For data collection we used questionnaires, interviews, participant observation while performing different tasks and oral presentations of work and outside observers. The results show that the integration of content and language has improved especially in oral communication. A comparative study with other less practical subjects could extend this work.

  19. Descripción de un Proceso Ecotoxicológico en el Departamento de Sustancias Activas del bloque II de la Planta de Producción III del Instituto Finlay.

    OpenAIRE

    Leidy Ureña Pérez; Nancy Hall Puebla; Jacqueline Aguiar Gutiérrez

    2005-01-01

    El Instituto Finlay es una institución farmacéutica dedicada a la investigación, desarrollo, producción y comercialización de vacunas al servicio de la medicina humana., comprometidos con la plena satisfacción de nuestros clientes nacionales e internacionales, apoyados en la competencia de nuestros recursos humanos, innovación, desarrollo de productos, tecnología actualizada, estrictos controles de calidad y orientados a la preservación del medio ambiente. Para este trabajo fueron trazados...

  20. Concepciones y creencias sobre el trabajo: Estudio descriptivo de algunas fuentes de variación en una muestra laboralmente activa Work Conceptions And Believes: A Descriptive Study On Some Sources Of Variation In A Working Sample

    Directory of Open Access Journals (Sweden)

    Elena Zubieta

    2008-12-01

    Full Text Available Desde una mirada psicosocial, el trabajo consiste en un conjunto de creencias y valores hacia el trabajo que los individuos y grupos sociales desarrollan antes y durante el proceso de socialización en el trabajo. Se trata de un conjunto flexible de cogniciones que está sujeto a cambios dependiendo de las vivencias personales y los cambios contextuales (Salanova, Gracia & Peiró;1996. Desde la perspectiva de la socialización en el trabajo y con el objetivo de explorar en probables fuentes de variación a partir de variables sociodemográficas, contextuales y psicosociales, se desarrolló un estudio descriptivo de diferencias de grupo sobre la base de una muestra no probabilística intencional por cuotas compuesta por 290 sujetos activos laboralmente de la Ciudad de Buenos Aires y el Conurbano Bonaerense. Los resultados muestran la presencia de creencias asociadas a la Ética Protestante del Trabajo y la Competitividad, valores de Apertura al Cambio y Autotrascendencia y configuraciones particulares a partir de introducir variables como el sexo, la edad, el nivel de educación y aspectos de trayectoria laboral tales como años de trabajo, permanencia en la organización y el puesto, interrupciones en la actividad laboral y modalidad de trabajo.From a psycho-sociological view, work can be understood as a set of values and beliefs which individuals and groups construct before and during work process socialization. It is a flexible set of cognitions influenced by individuals personal experiences and contextual changes (Salanova, Gracia & Peiró;1996. Taking socialization at work as a starting point and with the aim of exploring variation sources in terms of sociodemographic, contextual and psycho-sociological variables, a descriptive group differences study was carried out based on a convenience sample of 290 working participants from Buenos Aires city and surroundings. Results show the presence of Protestant Work Ethic, Competitive beliefs, Self- Trascendence and Open to Change values. There were also found interesting pro- files when introducing variables such as sex, age, educational levels and different work development aspects: working years, job and organization permanence, job interruption and work modality.

  1. La Ciudad sin Urbanismo: instalación residencial junto a secciones andinas inestables, dunas activas, bancos de arena y rodados fluviales. /The City without Urbanism: residential installation with unstable Andean sections, active dunes, sand banks and river pebbles.

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    Ferrando A., Francisco

    2002-01-01

    Full Text Available Durante los primeros meses del presente año aparecieron en la prensa una serie de informaciones sobre la "Falla de Ramón", o más bien "Falla de Ramón" (Börgel. El Mercurio 18/3/02. En ellas se presentan omisiones y contradicciones que pueden llevar a crear alarmismo y desconcierto en términos económicos, sociales y psicológicos, por lo cual la Sociedad Chilena de Ciencias Geográficas por intermedio del Prof. F. Ferrando A., Director de la Escuela de Geografía, F.A.U., de la Universidad de Chile considera pertinente discutir y aclarar algunos aspectos e incorporar otros antecedentes. /In the beginning of this year there were many news articles concerning the San Ramon Fault or Ramon Fault (Börgel, El Mercurio, March 18, 2002. In these articles there are contradictions and omissions that may result in confusion or panic in an economic, social and/or psychological sense. This is why the Sociedad Chilena de Ciencias Geográficas (Chilean Society of Geographic Science through the professor F. Ferrando A. Director of the Geography School, F.A.U. , of the University of Chile, advices the discussion and clarification of some matters concerning the Ramon Fault and also take new information on account.

  2. Características de la educación sexual escolar recibida y su asociación con la edad de inicio sexual y uso de anticonceptivos en adolescentes chilenas sexualmente activas

    OpenAIRE

    González A,Electra; Molina G,Temístocles; Luttges D,Carolina

    2015-01-01

    Antecedentes: La educación sexual integral en el contexto escolar es uno de los pilares fundamentales para prevenir embarazos e infecciones de transmisión sexual en adolescentes. Objetivo: Analizar las características de la educación sexual escolar recibida y su asociación con la edad de inicio sexual y uso de anticonceptivo en adolescentes consultantes en un centro de salud sexual y reproductiva. Método: Estudio analítico de corte transversal realizado en 1.232 adolescentes mujeres de nivel ...

  3. Eutanasia activa directa y consentimiento del sujeto pasivo como eximente de responsabilidad penal en eventos de enfermedades incurables no terminales. Una aproximación interdisciplinar desde el test de proporcionalidad en sentido estricto

    Directory of Open Access Journals (Sweden)

    Juan Carlos Cantillo Arcón

    2016-12-01

    Full Text Available This article is a research product about the legal implications of the direct-active euthanasia practiced by a doctor to a patient who has an incurable but non terminal disease which implies great suffering considering such by the current Colombian legal system, taking into account the victim’s consent as a cause of exempt criminal responsibility. Consequently, working from an interdisciplinary approach of criminal law as a science integrated to other legal and non-legal areas of knowledge, in order to develop a comprehensive analysis that contributes to academic discussions about the absence of criminal responsibility, constitutional study and medical activity practice. This product of research will show reflections and conclusions obtained from the analysis of the existent legal regulation about the availability of the protected legal right of life when practicing euthanasia (as described above. Additionally, we will see how the latter conduct constitutes a case of exempt criminal responsibility under the specified condition of “victim’s consent”, meaning that life is a disposable legal right when it competes, in the described factual circumstance, with the human dignity, applying the test of proportionality in strict sense.

  4. Estudio de la protección del refuerzo de partículas de SiC mediante barreras activas por sol-gel en materiales compuestos de matriz de aluminio

    Directory of Open Access Journals (Sweden)

    Ureña, A.

    2004-04-01

    Full Text Available A microcrystalline, homogeneous and transparent sol – gel silica coating has been developed to avoid the degradation and improve the wettability of aluminium matrix composites reinforced with SiC particles. Composite aluminium matrix samples have been made by cold powder compaction, and the coating efficiency has been checked by melting the samples several temperature and times. The coating reduces the appearance of Al4C3, showing that the degradation resistance of the new material is much higher than that of the uncovered SiC particles composite one.

    Con objeto de prevenir la degradación y mejorar la mojabilidad de los materiales compuestos de matriz de aluminio reforzados con partículas de SiC se ha desarrollado un recubrimiento microcristalino, homogéneo y transparente de SiO2 obtenido por el método sol-gel. La eficacia del recubrimiento como barrera se ha comprobado realizando ensayos de fusión a diferentes tiempos y temperaturas sobre pastillas de material compuesto de matriz de aluminio obtenidas por compactación en frío de polvos. El recubrimiento limita la formación de Al4C3, lo que indica que la resistencia a la degradación del nuevo material es muy superior a la del fabricado con partículas de SiC sin recubrir.

  5. Metodologías activas. Un estudio de AICLE/CLIL en Tecnología e Inglés / Active Learning. A study of CLIC/AICLE in Technology and English

    OpenAIRE

    Susana Warburton

    2017-01-01

    Resumen: Esta investigación recoge el trabajo realizado durante un periodo de dos cursos académicos en un centro concertado de la Comunidad valenciana, dentro de la metodología Aprendizaje Integrado de Contenidos y Lenguas Extranjeras (AICLE) o en inglés Content and Language Integrated Learning (CLIL). Las materias implicadas en esta investigación han sido la de tecnología y lengua inglesa del segundo ciclo de Educación Secundaria Obligatoria. Se parte d...

  6. Contribución a una visión económica del asociativismo religioso - el caso de la localización de las parroquias activas de Lisboa.

    Directory of Open Access Journals (Sweden)

    Paulo Reis Mourao

    2010-05-01

    Full Text Available ¿Donde están ubicadas las parroquias de Lisboa? ¿Qué explica la ubicación de estas parroquias? El presente trabajo, pionero en Portugal, responde a éstas dos preguntas. A través de la validación empírica, usando modelos logit, el artículo identifica como determinantes de la localización de las parroquias, la diversidad humana de las localidades y la tradición de las mismas; el artículo no confirma la hipótesis de la importancia del poder adquisitivo local. Consecuentemente, se confirma que las restricciones de recursos de éste tipo de grupos sociales incluyen la cultura y la tradición en detrimento de la exclusividad de las restricciones de presupuesto.

  7. Expresión de IL-10, IL-4 e IFN-γ en lesiones activas de piel en niños con urticaria papular por picadura de pulga

    Directory of Open Access Journals (Sweden)

    Elizabeth García

    2011-06-01

    Conclusiones. Los datos corresponden a la primera descripción de citocinas que median la respuesta inmunitaria en el sitio de la lesión cutánea en niños con con urticaria papular por picadura de pulga, lo cual indica que la respuesta local es mixta ya que no se encuentra predominio de un fenotipo específico en ninguno de los pacientes.

  8. Sistema de medición, control y compensación activa para ciclado de campo magnético en aplicaciones de resonancia magnética nuclear

    OpenAIRE

    Forte, Guillermo Omar

    2013-01-01

    Tesis (DCI)--FCEFN-UNC, 2013 Analiza aspectos de la instrumentación asociada a la técnica de Resonancia Magnética Nuclear (RMN) con Ciclado Rápido de Campo Magnético (FFC, por sus siglas en inglés), los que afectan directamente la calidad de las mediciones realizadas. Se implementó un método para la corrección estática de la dependencia espacial del campo magnético generado por el electroimán principal del sistema, dentro de un volúmen determinado.

  9. Ciudadanía activa y alfabetización mediática : el papel de las asociaciones de telespectadores y usuarios de los medios en el nuevo escenario audiovisual

    OpenAIRE

    Fuente Cobo, Carmen

    2010-01-01

    La nueva Ley General de la Comunicación Audiovisual aborda la alfabetización mediática como un objetivo exigible tanto a los poderes públicos como a las empresas audiovisuales y encomienda al Consejo Estatal de Medios Audiovisuales (CEMA) la misión de velar por este objetivo. La Ley también prevé la participación ciudadana, a través de asociaciones y entidades representativas, en la configuración del entorno mediático. La comunicación aborda el posible papel de las asociacio...

  10. [Effects of Electroacupunctrue Combined with Dietary Control on Peroxisome Proliferator-activa- ted Receptor-α, and Liver Fatty Acid-binding Protein Levels in Non-alcoholic Fatty Liver Disease Rats].

    Science.gov (United States)

    Zhang, Yi; Tang, Cheng-lin; Tian, Yuan; Yuan, Hai-zhou; Yang, Hui; Tang, Nian-zhen; Gao, Rui-qi; Cao, Jing

    2015-10-01

    To observe the effect of electroacupunctrue (EA) intervention or EA combined with dietary control on peroxisome proliferator-activated receptor (PPAR)-α, and liver fatty acid-binding protein (L-FABP) levels in non-alcoholic fatty liver disease (NAFLD) rats, so as to reveal its mechanism underlying improvement of NAFLD. Sixty SD male rats were randomly divided into common diet (control) group (n = 10) and high-fat diet group (n = 45). The NAFLD model was established by feeding the animals with high-fat forage (HFF, including cholesterol, sodium cholate, propylthiouracil, sucrose, lard and common forage) for 5 weeks. Forty NAFLD rats were then randomized into model, EA + HFF, low-fat forage (LFF) and EA+ LFF groups (n = 10 rats in each group). EA (4 Hz/20 Hz, 3 mA) was applied to ipsilateral "Zusanli" (ST 36),"Sanyinjiao" (SP 6) and "Taichong" (LR 3) for 20 min, once daily for 4 weeks. The pathologic changes of the hepatic tissue were detected by H. E. staining. Serum total cholesterol (TC) and triglyceride (TG) contents were determined by using enzymatic methods, serum free fat acids (FFA) content was detected by colorimetry. The expression levels of PPAR-α and L-FABP protein and gene of the liver tissue were determined by Western blot and RT-PCR, respectively. H. E. staining showed that the hepatocytes presented moderate or severe bullous adipose degeneration in rats of the model group, vesicular steatosis in the EA + HFF and LFF groups, turned to almost normal but with small amount of lipid droplets in the EA + LFF group. The contents of serum TC, TG and FFA were significantly higher in the model group than in the control group (P < 0.05), and were obviously decreased in the EA + HFF, LFF and EA + LFF groups in comparison with the model group (P < 0.05). Compared to the control group, hepatic PPAR-α protein and mRNA were markedly down-regulated in the model group, and hepatic L-FABP protein and mRNA considerably up-regulated in the model group (P < 0.05). Following EA intervention and low fat diet feeding, PPAR-α protein and mRNA were markedly up-regulated while L-FABP protein and mRNA remarkably down-regulated in the EA + HFF, LFF and EA + LFF groups (P < 0.05). EA intervention or EA combined with dietary control can relieve hepatic pathological changes in NAFLD rats, which may be related to its effects in down-regulating blood lipid level and hepatic L-FABP protein and mRNA expression and in up-regulating PPAR-α protein and mRNA expression, and the effect of combined treatment was relatively better than simple EA or LFF treatment.

  11. La mujer mexicana económicamente activa: ¿son confiables los microdatos censales? Una prueba a través de censos y encuestas. México y Estados Unidos, 1970-1990

    Directory of Open Access Journals (Sweden)

    Gabriela Vázquez

    2000-01-01

    Full Text Available La propuesta temática de este artículo se sustenta en el desarrollo del proyecto Microdatos Seriados e Integrados de Uso Público Internacional (IPUMS, que inició en octubre de 1999, auspiciado por el Minnesota Population Center (MPC de la Universidad de Minnesota. Intentamos probar la utilidad de una base de datos como la que propone crear IPUMS. Así, a pesar de que no se cuenta aún con datos integrados, procuraremos mostrar la potencialidad de la fuente de datos que agrupe información censal de diferentes países. Dentro de una perspectiva comparativa, hemos desarrollado un análisis multivariado a través de la comparación entre censos y la Encuesta Nacional de Empleo Urbano (ENEU, tanto en el tiempo (1970 y 1990 como entre países (México y Estados Unidos, refiriéndonos a la mujer mexicana, en particular a partir del estudio de la fuerza de trabajo femenina.

  12. Evaluación posoperatoria de los pacientes con úlcera perforada

    OpenAIRE

    López Rodríguez, Pedro; Pol Herrera, Pablo; Cruz Alonso, Juan Ramón; León González, Olga; Anaya González, Jorge Luis

    2013-01-01

    Introducción: la úlcera péptica gastroduodenal constituye después de la hemorragia la complicación ulcerosa más frecuente y la más grave de todas. Ocurre entre el 2 y 5 % de los pacientes con enfermedad ulcerosa y sus síntomas son provocados por la acción del jugo gástrico derramado en la cavidad abdominal. Objetivo: valorar la evolución de los pacientes operados de urgencia con el diagnóstico de úlcera gastroduodenal perforada. Métodos: se realizó un estudio observacional descriptivo con car...

  13. Proctocolectomía restauradora: A propósito de 2 casos en un hospital general

    Directory of Open Access Journals (Sweden)

    Luis Augusto Borda Mederos

    2009-10-01

    Full Text Available Se presentan 2 pacientes sometidos a proctocolectomía restauradora, el primero con colitis ulcerosa y el segundo con poliposis adenomatosa familiar. Se discuten la efectividad de la técnica, el seguimiento a corto plazo de estos pacientes y las indicaciones para proctocolectomía restauradora.(Rev Med Hered 2009;20:230-234.

  14. Severe side effects with the application of Mesalazine (5-aminosalicylic acid) during radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Freund, U.; Siems, H.; Wannenmacher, M.; Schoelmerich, J.; Kluge, F.; Schaefer, H.E.

    1987-10-01

    In a prospective randomized placebo controlled double blind study, the prophylactic effect of Mesalazine (5-aminosalicylic acid, 5-ASA) as suppositories (3x250 mg/day) on radiation induced proctitis during radiotherapy for prostatic carcinoma was studied. The study ended when 16 patients had been included (5-ASA: Eight, placebo: Eight) because of severe side effects in the 5-ASA group. 75% of patients treated with 5-ASA reported symptoms of a severe proctitis while only one patient in the placebo group had similar complaints. The application of Mesalazine as suppositories is not useful in preventing radiation induced proctitis during radiotherapy of prostate carcinoma.

  15. Severe side effects with the application of Mesalazine (5-aminosalicylic acid) during radiotherapy

    International Nuclear Information System (INIS)

    Freund, U.; Siems, H.; Wannenmacher, M.; Schoelmerich, J.; Kluge, F.; Schaefer, H.E.

    1987-01-01

    In a prospective randomized placebo controlled double blind study, the prophylactic effect of Mesalazine (5-aminosalicylic acid, 5-ASA) as suppositories (3x250 mg/day) on radiation induced proctitis during radiotherapy for prostatic carcinoma was studied. The study ended when 16 patients had been included (5-ASA: Eight, placebo: Eight) because of severe side effects in the 5-ASA group. 75% of patients treated with 5-ASA reported symptoms of a severe proctitis while only one patient in the placebo group had similar complaints. The application of Mesalazine as suppositories is not useful in preventing radiation induced proctitis during radiotherapy of prostate carcinoma. (orig.) [de

  16. Calendula

    Science.gov (United States)

    ... the skin (used topically) for nosebleeds, varicose veins, hemorrhoids, inflammation of the rectum (proctitis), and inflammation of ... circulation. Muscle spasms. Fever. Cancer. Nosebleeds. Varicose veins. Hemorrhoids. Promoting menstruation. Treating mouth and throat soreness. Wounds. ...

  17. Levator Syndrome

    Science.gov (United States)

    ... Abscess Anorectal Fistula Foreign Objects in the Rectum Hemorrhoids Levator Syndrome Pilonidal Disease Proctitis Rectal Prolapse (See ... out other painful rectal conditions (such as thrombosed hemorrhoids , fissures , or abscesses ). The physical examination is often ...

  18. Acid Reflux (GER and GERD) in Adults

    Science.gov (United States)

    ... Treatment Eating, Diet, & Nutrition Clinical Trials Peptic Ulcers (Stomach Ulcers) Definition & Facts Symptoms & Causes Diagnosis Treatment Eating, Diet, & Nutrition Clinical Trials Proctitis Definition & Facts Symptoms & ... Definition & Facts Symptoms & Causes Diagnosis Treatment Eating, ...

  19. Akut iskaemisk proktitis efter et epileptisk anfald

    DEFF Research Database (Denmark)

    Klintmann, Camille Kristine; Hillingsø, Jens; Glenthøj, Anders

    2008-01-01

    Acute ischemic proctitis is a rare diagnosis mainly because the rectum is supplied by an extensive arterial network. Consequently, in more than 90% of patients with ischemic colitis the rectum is spared. Previously reported cases are related to severe vascular insufficiency of the rectal circulat...... circulation caused by systemic atherosclerosis, usually following aortic or aortoiliac operations. We report one case of acute ischemic proctitis following an epileptic attack....

  20. Diseño e implementación de un programa de salud ocupacional en el personal administrativo del Gobierno Autónomo Descentralizado municipal del cantón Guamote mediante la aplicación de pausas activas para mejorar la satisfacción laboral.

    OpenAIRE

    Cepeda Arias, Fernando Paúl

    2017-01-01

    The following research deais with the implementation of a Health program within the administrative area of the Autonomous Municipal Decentralized Government of Guamote municipality ¡n order to control psychosocial risks and the increase of job satisfaction. The research was carried out in three stages. Firstly, an initial evaluation of job satisfaction of the sample group was carried out based on the technical standard of prevention NTP 212, secondly, the health program was developed and impl...

  1. Implementación de un plan de pausas activas para la disminución de los índices de estrés en los funcionarios de la subsecretaría de fortalecimiento del conocimiento y becas de la secretaría de educación superior ciencia, tecnología e innovación

    OpenAIRE

    Flores Saá, Daniel Alejandro

    2016-01-01

    The plan of active pauses in the "Casa Navarro" was successful and took place with normality in the planned weeks, it was possible to rely on in average the assistance of 98 % of the sample (22 people), since we were at the expense of coordinators agenda. At the beginning the participants were hoping that the manager of the process would invite them to participate in the active pauses, however as the time passed the employees had their own initiative to start the activitie...

  2. Sostenibilitat, participació i educació: les concepcions del món i de la tecnociència en la transformació dels conflictes socioambientals. Una aproximació metodològica per al desenvolupament de capacitats de sostenibilitat activa des de l'aprenentatge de la tecnologia

    OpenAIRE

    Lobera Serrano, Josep A.

    2010-01-01

    L'ésser humà sempre ha estat en contínua interacció amb el seu medi, una interacció que no ha estat exempta de tensions. Des de l'antiguitat diversos registres mostren en diverses societats la consciència de la interdependència entre les societats humanes i el medi natural en què es troben, que habitualment es tradueix en un interès pragmàtic per conservar l'entorn de què depenen per a la seva supervivència. En el moment actual, aquestes interaccions de les societats humanes amb el seu ambien...

  3. Ophiolite Emplacement and the Effects of the Subduction of the Active Chile Ridge System: Heterogeneous Paleostress Regimes Recorded in the Taitao Ophiolite (Southern Chile Emplazamiento de ofiolitas y los efectos de la subducción de la dorsal activa de Chile: Regímenes heterogéneos de paleostress registrados en la Oflolita Taitao (Sur de Chile

    Directory of Open Access Journals (Sweden)

    Eugenio E Veloso

    2009-01-01

    Full Text Available The repeated north and southward migration of the Chile Triple junction, offshore the Península de Taitao, is expected to have imposed contrasting stress fields in the forearc for the last 6 Ma because of changes in convergence direction and rate of subducting plates. NNW-SSE to E-W and minor NE-SW striking brittle faults developed in the plutonic units of the Mio-Pliocene Taitao Ophiolite, whereas NNE-SSW and minor NW-SE trending faults developed in its eastern border (Bahía Barrientes fault-zone. These brittle faults are studied to elucídate the style of ophiolite emplacement and the tectonic effects resulting from the alternated migration of the Chile Triple junction in the área. Analyses of heterogeneous fault-slip data on both áreas suggest that faults were activated by different stress fields. Two different compressional stress fields were identified in the plutomc units (A and B, whereas three different stress fields, ranging from compressional to strike-slip, were identified in the BahíaBarrientos fault-zone (C, D and E. Calculated directions of Oj axes for A, C, D and E solutions are mostly E-W trending, roughly similar to the convergence direction of subducting plates, whereas that for B solution is counterclockwise rotated ca. 60° with respect to the previous E-W trend. Brittle structures related to solution B were attributed to an early deformation of the ophiolite, most probably developed shortly after its emplacement {ca. 6 Ma. These structures were further counterclockwise rotated, while new structures (related to solution A developed in the plutomc units in order to absorb the continuous deformation. In the eastern margin of the ophiolite, the stress field divided inte compressional and strike-slip components. During periods of relatively strong compression (fast subduction of the Nazca píate, the fault-zone experienced well defined compressional and strike-slip movements (solutions C and D. In contrast, during periods of relatively weak compression (slow subduction of the Antarctic píate, the fault-zone experienced a complex mixture of thrust and strike-slip movements (solution E. Thus, the wide range of calculated stress ratios for all solutions could be attributed to the alternated change in convergent velocity of the subducting plates beneath the Taitao área.Es esperable que la repetida migración norte-sur del Punto Triple de Chile cercana a la costa de la Península de Taitao haya impuesto campos de esfuerzos distintos en el antearco por los últimos 6 Ma debido a cambios en la dirección de convergencia y tasa de subducción. Fallas con rumbos NNO-SSE y E-O y otras menores con rumbos NE-SO se desarrollaron en las unidades plutónicas de la Oflolita Miocena-Pliocena de Taitao, mientras que fallas con rumbos NNE-SSO y otras menores con rumbos NO-SE se desarrollaron en el borde Este de esta (Zona de falla de Bahía Barrientes. Estas estructuras frágiles son estudiadas para dilucidar el estilo de emplazamiento de la oflolita y los efectos tectónicos resultantes de la migración alternada del Punto Triple de Chile en al área. Análisis de datos heterogéneos de fallas en ambas áreas sugieren que fueron activadas por campos de esfuerzos diferentes. Dos campos de stress compresionales distintos fueron identificados en las unidades plutónicas (A y B, mientras que 3 campos de stress diferentes, desde compresionales a transcurrentes, lo fueron en la zona de falla de Bahía Barrientes (C, D y E. Las direcciones de los ejes a1 calculadas para las soluciones A, C, D y E son principalmente este-oeste, similares a la dirección de convergencia de las placas subductantes, mientras que aquella para la solución B está rotada antihorario ca. 60° con respecto del patrón anterior este-oeste. Las estructuras frágiles relacionadas con la solución B fueron atribuidas a una deformación temprana de la ofiolita, muy probablemente desarrolladas después de su emplazamiento (ca. 6 Ma. Estas estructuras fueron posteriormente rotadas antihorario, mientras nuevas estructuras (relacionadas con la solución A se desarrollaron en las unidades plutónicas para absorber la deformación continua. En el margen este de la ofiolita, el campo de esfuerzo se dividió en componentes compresionales y transcurrentes. Durante períodos de compresión relativamente alta (subducción rápida de la placa de Nazca la zona de falla experimentó movimientos compresionales y transcurrentes bien definidos (soluciones C y D. En contraste, durante períodos de relativa baja compresión (lenta subducción de la placa Antartica la zona de falla experimentó una compleja mezcla de movimientos inversos y transcurrentes (solución E. Así, el amplio rango de radios de stress calculados para todas las soluciones puede ser atribuido al cambio alternado en la velocidad de convergencia de las placas subductantes bajo el área de Taitao.

  4. La enseñanza/aprendizaje del concepto de Reología en estudiantes de Química Farmacéutica de la Universidad de Antioquía, a partir de una metodología activa

    OpenAIRE

    Archbold Joseph, Rosendo Ricardo

    2017-01-01

    La educación contemporánea universitaria está haciendo todo lo posible para que sus egresados sean propositivos, creativos y preocupados por una formación continua y permanente. De ahí, y centrado en el marco teórico de la línea del Aprendizaje Significativo de Ausubel y Aprendizaje Significativo Critico de Moreira y al trabajo con acompañamiento basado en el concepto de ZDP de Vygotsky, tomamos algunas ideas fundamentales de estas teorías tratando de intégralas como eje del proceso de aprend...

  5. “¿La revolución tiene cara de campesina?” Un caso de estudio de la participación activa de las mujeres en el riego del páramo venezolano "Has the Revolution a Peasant Face?" A case study on the activeparticipation of women in an irrigation project in the Venezuelan Páramo

    OpenAIRE

    Caretta, Martina Angela; Cadena Montero, Yulier Cadena; Sulbaran, Luisana; Sandoval, Rafael

    2015-01-01

    En Venezuela, la participación de la mujer en los procesos de tomas de decisiones ha sido profundizada por la revolución bolivariana. Mientras se ha demostrado que los cambios legislativos han logrado involucrar a las mujeres en las zonas urbanas, no existen estudios al respecto equivalentes en las zonas rurales. Este artículo es un primer paso para solventar dicha carencia científica. Se han utilizado para ello metodologías cualitativas y un enfoque de género para conocer la participación de...

  6. Inmunogenicidad de la vacuna frente al virus de la hepatitis B en pacientes con enfermedad inflamatoria intestinal

    OpenAIRE

    Olsen Rodríguez, Renée

    2017-01-01

    La colitis ulcerosa (CU) y la enfermedad de Crohn (EC) son patologías que se denominan conjuntamente enfermedad inflamatoria intestinal (EII). Su patogenia es poco conocida, pero si se sabe que hay una respuesta inmune frente a estructuras del tubo digestivo. El tratamiento se basa es disminuir esta inmunogenicidad administrando corticoides, inmunosupresores o terapias biológicas. Todas estas circunstancias favorecen las infecciones y reactivaciones por el virus de la hepatitis B (VHB). La pr...

  7. Ernährungszustand bei Patienten mit chronisch entzündlichen Darmerkrankungen

    OpenAIRE

    Blunk, Christine

    2009-01-01

    Zahlreiche internationale Studien konnten den negativen Einfluss einer bestehenden Malnutrition auf den Verlauf einer Erkrankung belegen. Dies gilt insbesondere für Patienten mit chronisch entzündlichen Darmerkrankungen wie Morbus Crohn und Colitis ulcerosa, die wie klinische Studien gezeigt haben besonders häufig unter einer Malnutrition leiden. In der vorliegenden Studie wurde der Ernährungszustand von 127 Patienten mit chronisch entzündlichen Darmerkrankungen anhand verschiedener etabli...

  8. Preparation and characterization of PAN–KI complexed gel polymer ...

    Indian Academy of Sciences (India)

    The conductivity-temperature dependence of these polymer electrolyte films obeys Arrhenius behaviour with activa- ... oxide (PEO), polyvinyl alcohol, polyvinyl pyrrolidone (PVP) ... chemical, flame resistance and electrochemical stability.

  9. DMPD: Are the IKKs and IKK-related kinases TBK1 and IKK-epsilon similarly activated? [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 18353649 Are the IKKs and IKK-related kinases TBK1 and IKK-epsilon similarly activa...e IKKs and IKK-related kinases TBK1 and IKK-epsilon similarly activated? PubmedID... 18353649 Title Are the IKKs and IKK-related kinases TBK1 and IKK-epsilon similarly activated? Authors Chau

  10. Rectal necrosis following external radiation therapy for carcinoma of the prostate: report of a case

    International Nuclear Information System (INIS)

    Quan, S.H.Q.; O'Kelly, P.J.

    1975-01-01

    Increasing attention is being paid to the use of radiation therapy in the management of primary carcinoma of the prostate. Since 1965, radical radiation therapy has been used at Memorial Hospital to treat primary carcinoma of the prostate. Small primary tumors are treated by implantation with radioactive iodine ( 125 I) seeds and larger tumors considered unsuitable for implantation are treated by external supervoltage beam therapy. Fifty patients had been treated by implantation and 30 by external beam therapy at the time of this report. None of the patients treated by implantation developed rectal symptoms. Proctitis developed in all patients treated by external radiation therapy and in half the patients chronic proctitis ensued, accompanied by the passage of mucus. The constant leaking of mucus through the anal sphincter produces irritation of the skin and intermittent attacks of pruritus ani, a discomfiting sequel. Apart from the proctitis, most patients tolerated treatment well, with one notable exception, in whom rectal necrosis developed. This case is described

  11. Clinical significance of increased gelatinolytic activity in the rectal mucosa during external beam radiation therapy of prostate cancer

    International Nuclear Information System (INIS)

    Hovdenak, Nils; Wang Junru; Sung, C.-C.; Kelly, Thomas; Fajardo, Luis F.; Hauer-Jensen, Martin

    2002-01-01

    Purpose: Rectal toxicity (proctitis) is a dose-limiting factor in pelvic radiation therapy. Mucosal atrophy, i.e., net extracellular matrix degradation, is a prominent feature of radiation proctitis, but the underlying mechanisms are not known. We prospectively examined changes in matrix metalloproteinase (MMP)-2 and MMP-9 (gelatinase A and B) in the rectal mucosa during radiation therapy of prostate cancer, as well as the relationships of these changes with symptomatic, structural, and cellular evidence of radiation proctitis. Methods and Materials: Seventeen patients scheduled for external beam radiation therapy for prostate cancer were prospectively enrolled. Symptoms of gastrointestinal toxicity were recorded, and endoscopy with biopsy of the rectal mucosa was performed before radiation therapy, as well as 2 and 6 weeks into the treatment course. Radiation proctitis was assessed by endoscopic scoring, quantitative histology, and quantitative immunohistochemistry. MMP-2 and MMP-9 were localized immunohistochemically, and activities were determined by gelatin zymography. Results: Symptoms, endoscopic scores, histologic injury, and mucosal macrophages and neutrophils increased from baseline to 2 weeks. Symptoms increased further from 2 weeks to 6 weeks, whereas endoscopic and cellular evidence of proctitis did not. Compared to pretreatment values, there was increased total gelatinolytic activity of MMP-2 and MMP-9 at 2 weeks (p=0.02 and p=0.004, respectively) and 6 weeks (p=0.006 and p=0.001, respectively). Active MMP-2 was increased at both time points (p=0.0001 and p=0.002). Increased MMP-9 and MMP-2 at 6 weeks was associated with radiation-induced diarrhea (p=0.007 and p=0.02, respectively) and with mucosal neutrophil infiltration (rho=0.62). Conclusions: Pelvic radiation therapy causes increased MMP-2 and MMP-9 activity in the rectal mucosa. These changes correlate with radiation-induced diarrhea and granulocyte infiltration and may contribute to abnormal

  12. The pitfalls of treating anorectal conditions after radiotherapy for prostate cancer.

    LENUS (Irish Health Repository)

    Thornhill, J A

    2012-03-01

    We present a salutary lesson learned from three cases with significant complications that followed anorectal intervention in the presence of radiation proctitis due to prior radiotherapy for adenocarcinoma of the prostate. After apparent routine rubber band ligation for painful haemorrhoids, one patient developed a colo-cutaneous fistula. Following laser coagulation for radiation proctitis, one patient required a pelvic exenteration for a fistula, while another developed a rectal stenosis. Those diagnosing and treating colonic conditions should be mindful of the increased prevalence of patients who have had radiotherapy for prostate cancer and the potential for complications in treating these patients.

  13. “Elaboración y aplicación de una guía de buenas prácticas ambientales “amigos del ambiente” con estrategias activas que desarrolle la inteligencia naturalista en los estudiantes del noveno año del colegio municipal Sebastián de Benalcázar de la ciudad de Quito, provincia de Pichincha. período 2013.

    OpenAIRE

    Salinas Abril, Edison Gonzalo

    2015-01-01

    Dos problemas básicos han motivado el desarrollo de la presente investigación: el primero se refiere a la falta de concienciación de los habitantes de Quito hacia el medio ambiente; basura arrojada en las calles; dispositivos eléctricos, electrónicos, baterías, etc; los roedores que se alimentan del desecho causan además un gran impacto en el ecosistema urbano de la capital patrimonio de la humanidad; por otro lado el desperdicio del agua por doquier que tanta falta hace en otras partes denot...

  14. Implicación del estrés psicosocial y los factores psicológicos en la dispepsia funcional

    OpenAIRE

    Tobón, Sergio; Vinaccia, Stefano; Sandín, Bonifacio

    2003-01-01

    El objetivo del presente artículo ha consistido en llevar a cabo un análisis crítico sobre la dispepsia no ulcerosa o dispepsia funcional (DF) y sobre su relación con el estrés psicosocial y otros factores psicológicos. Se revisa la implicación de estos factores partiendo de la naturaleza multifactorial de la DF. La evidencia revisada sugiere que los sucesos vitales, la ansiedad, los trastornos de ansiedad, la depresión, algunos síntomas psicopatológicos, la somati...

  15. Perforated gastroduodenal peptic ulcer: a study of operated patients

    OpenAIRE

    Bejerano García, Ramiro Julio

    2007-01-01

    Se realizó un estudio de los pacientes operados por úlcera péptica gastroduodenal perforada en el Hospital Provincial Docente Clinicoquirúrgico «Dr. Ambrosio Grillo Portuondo» (Santiago de Cuba), entre los años 2000 y 2006. En el estudio predominaron los pacientes en la tercera década de la vida (30,3 %) y el sexo masculino (90 %). En la mayoría de los pacientes (68,7 %) la perforación fue una complicación de enfermedad ulcerosa y predominó entre ellos el nivel medio de escolaridad (67,7 %). ...

  16. Ebrotidina: nuevo antagonista H2

    Directory of Open Access Journals (Sweden)

    Noel Padrón Pérez

    1999-01-01

    Full Text Available Se realizó una revisión bibliográfica sobre un nuevo antagonista H2, la ebrotidina, que exhibe ventajas con respecto a otros medicamentos antisecretores. Las propiedades gastroprotectoras y la actividad anti H. pylori del fármaco, en el tratamiento de la enfermedad péptica ulcerosa, se mencionan en el presente trabajo.A bibliographic review on the new H2 antagonist, ebrotidine, that presents advantages in comparison with other antisecretory drugs, is made. The gastroprotective properties and the anti H. pylori activity of the drug in the treatment of peptic ulcer are mentioned in this paper.

  17. Distribution of some elements in human colon mucosa

    International Nuclear Information System (INIS)

    Drashkovich, R.J.

    1985-01-01

    The contents of Co, Zn, Fe, Cr and Sb were determined in human colon mucosa as a function of pathalogical alterations during development of colitis Chronica, Colitis Ulcerosa, Adenoma Tubulare and Adenocarcinoma. The sample (0.00023-0.00087 kg in weight) from 80 patients were taken during rectosigmoidoscopy by teflon coated forceps and were deep frozen (T=244 deg. K) and liophilysed. A thermal neutron fluxes 0.54-1.85x10 17 n/m 2 .s for 3 days and 4096-channel analyser with a Ge(Li) detector

  18. Helicobacter pylori y dispepsia, un problema de salud comunitario

    Directory of Open Access Journals (Sweden)

    Miguel González-Carbajal Pascual

    2002-06-01

    Full Text Available Mientras la relación causal entre el Helicobacter pylori y la gastritis crónica, así como la importante conexión entre esta infección, la úlcera gastroduodenal y el cáncer gástrico han sido bien establecidas, la asociación entre la infección por Helicobacter pylori y la dispepsia "no ulcerosa" es un problema que dista mucho de estar esclarecido. Hay autores que no dudan en utilizar tratamiento de erradicación en la dispepsia "no ulcerosa" con Helicobacter pylori, pero existen enfoques alternativos a este problema. La realización de tratamiento de erradicación en los pacientes con dispepsia "no ulcerosa" pudiera beneficiar o no a los enfermos y a la comunidad, pero seguramente no puede dejar de beneficiar a las transnacionales productoras de medicamentos que cosechan cuantiosas ganancias con la comercialización de los bloqueadores de la bomba de protones y los antibióticos que se incluyen en cualquier esquema de terapia erradicadora de la infección por Helicobacter pylori. El alivio de los síntomas dispépticos como consecuencia del tratamiento de erradicación del Helicobacter pylori no ha sido comprobado. El problema de realizar tratamiento de erradicación de la infección a los pacientes con dispepsia "no ulcerosa" continúa siendo un dilema y, por tanto, no debe indicarse sistemáticamente.Although the causative relationship between Helicobacter pylori and chronic gastritis as well as the important connection of this infection with gastric-duodenal ulcer and gastric cancer are well established, the association of Helicobacter pylori infection and non-ulcer dispepsia is a problem that is still unclear. Some authors do not hesitate in using Helicobacter pylori eradication treatment in cases of non-ulcer dispepsia but there are other alternative approaches to this problem. The eradication treatment in patients with non-ulcer dispepsia may or may not benefit patients and the community, but will benefit for sure the big drug

  19. Trichorhinophalangeal syndrome

    Energy Technology Data Exchange (ETDEWEB)

    Tuzovic, S.; Fiebach, B.J.O.; Magnus, L.; Sauerbrei, H.U.

    1982-11-01

    This article reports on 14 cases of a trichorhinophalangeal syndrome in five successive generations. Besides the well-known characteristics of the TRPS the following symptoms observed in this family are new: Teething was considerably delayed, intelligence was reduced, and there were skin manifestations resembling eczema. Besides, struma colli and colitis ulcerosa were also observed. Subsequent observations have to clarify whether these symptoms are a facultative part of the TRPS pattern. The constant appearance of carriers of these characteristics during five generation points to dominant heredity.

  20. The trichorhinophalangeal syndrome

    International Nuclear Information System (INIS)

    Tuzovic, S.; Fiebach, B.J.O.; Magnus, L.; Sauerbrei, H.U.

    1982-01-01

    This article reports on 14 cases of a trichorhinophalangeal syndrome in five successive generations. Besides the well-known characteristics of the TRPS the following symptoms observed in this family are new: Teething was considerably delayed, intelligence was reduced, and there were skin manifestations resembling eczema. Besides, struma colli and colitis ulcerosa were also observed. Subsequent observations have to clarify whether these symptoms are a facultative part of the TRPS pattern. The constant appearance of carriers of these characteristics during five generation points to dominant heredity. (orig.) [de

  1. Graduated diagnostics required. Broad spectrum of differential diagnoses

    International Nuclear Information System (INIS)

    Auer, I.O.

    1997-01-01

    The time lapse between initial symptoms and secured diagnosis of colitis ulcerosa still is 6-8 weeks, in case of M. Crohn even about 30 weeks. A graduated diagnostic approach is required: phase 1 relies on non-invasive methods such as anamnesis, physical examination, examination of stools, blood chemistry and sonography of the abdomen; phase 2 ecompasses endoscopy and radiological techniques, phase 3 computed tomography and MRI for detection of complications. The results of the leucodiagnosis by scintiscanning, for detection of inflammations of and out of the intestine, offer a still inhomogenous picture in terms of sensitivity and specificity. (orig./MG) [de

  2. Antimicrobial susceptibility pattern of Neisseria gonorrhoeae ...

    African Journals Online (AJOL)

    chronic pelvic pain, infertility, acute urethritis, cervicitis and proctitis or pharyngitis [5]. N. gonorrhoeae infections represent 106 million of the estimated 498 million new cases of curable sexually transmitted infection that occur globally every year [5]. Previous studies have estimated. 3.4 million cases of gonorrhea among ...

  3. Influence of intestinal inflammation (IBD) and small and large bowel length on fecal short-chain fatty acids and lactate

    DEFF Research Database (Denmark)

    Hove, H; Mortensen, P B

    1995-01-01

    with pancolitis (mean +/- SEM, 17 +/- 5 mmol/liter) and proctitis (12 +/- 3 mmol/liter) compared with quiescent ulcerative colitis (3 +/- 1 mmol/liter, P liter......), but not in isolated ileitis (4 +/- 2 mmol/liter), compared with quiescent Crohn's disease (7 +/- 2 mmol/liter, P

  4. Chlamydia trachomatis in Cervical Lymph Node of Man with Lymphogranuloma Venereum, Croatia, 20141.

    Science.gov (United States)

    Gjurašin, Branimir; Lepej, Snježana Židovec; Cole, Michelle J; Pitt, Rachel; Begovac, Josip

    2018-04-01

    We report an HIV-infected person who was treated for lymphogranuloma venereum cervical lymphadenopathy and proctitis in Croatia in 2014. Infection with a variant L2b genovar of Chlamydia trachomatis was detected in a cervical lymph node aspirate. A prolonged course of doxycycline was required to cure the infection.

  5. Bubonic lymphogranuloma venereum with multidrug treatment failure.

    Science.gov (United States)

    Vall-Mayans, Martí; Isaksson, Jenny; Caballero, Estrella; Sallés, Beatriz; Herrmann, Björn

    2014-03-01

    A patient with proctitis and inguinal buboes diagnosed with lymphogranuloma venereum (LGV) was treated with doxycycline 21 days, azithromycin 20 days and moxifloxacin for a further 12 days because of progressive worsening of inguinal symptoms. Despite extensive antibiotic treatment, the inguinal LGV lesions persisted; however, the patient recovered spontaneously after three months.

  6. European guideline for the management of lymphogranuloma venereum, 2010

    NARCIS (Netherlands)

    de Vries, H.J.C.; Morré, S.A.; White, J.A.; Moi, H.

    2010-01-01

    Lymphogranuloma venereum (LGV) has re-emerged among European men who have sex with men (MSM) in recent years and is probably endemic in this population where it is a relatively common cause of proctitis and occasional genital ulcer-adenopathy disease. While occasional cases of heterosexual LGV are

  7. Production potentials of anti-Plesiomonas shigelloides antibody

    African Journals Online (AJOL)

    hope&shola

    2006-02-02

    Feb 2, 2006 ... Sci. 71: 5083-5087. Nolte FS, PooleRM, Murphy GW, Clark, Ranner BJ (1988). Proctitis and fatal septicemia and cause by P. shigelloides in a bisexual man. J. Clin. Microbiol. 26: 388-391. Obi CL,Coker AO (1988). Production of antisera against Campylobacter species in Lagos, Nigeria. Cent. Afr. J. Med.

  8. ''Lo comunitario a la luz de la sombra´´. Imaginarios del profesional de la salud en lo comunitario

    OpenAIRE

    Duque Robayo, Angela María

    2001-01-01

    Tesis de grado (Maestría en Pedagogías Activas y Desarrollo Humano). Centro Internacional de Educación y Desarrollo humano -Cinde-Universidad de Manizales. Facultad de Ciencias Sociales y Humanas, 2001

  9. Impaired voluntary neuromuscular activation limits muscle power in mobility-limited older adults

    Science.gov (United States)

    Background. Age-related alterations of neuromuscular activation may contribute to deficits in muscle power and mobility function. This study assesses whether impaired activation of the agonist quadriceps and antagonist hamstrings, including amplitude- and velocity-dependent characteristics of activa...

  10. Situation of the sustainable mobility plans in Spain

    OpenAIRE

    Diez, Jose Maria; Gonzalo Orden, Hernán; Velasco, Lara; López Lambas, María Eugenia

    2013-01-01

    Ponencia presentada en: Participación ciudadana activa para la Planificación de la Movilidad Urbana Sostenible (PMUS) : Engaging in a dynamic dialogue for Sustainable Urban Mobility Planning (SUMP). Summer University 2013

  11. Susceptibilidad de las bacterias aisladas de infecciones gastrointestinales agudas a la rifaximina y otros agentes antimicrobianos en México

    Directory of Open Access Journals (Sweden)

    O. Novoa-Farías

    2016-01-01

    Conclusiones: La resistencia de las bacterias enteropatógenas a antimicrobianos utilizados en gastroenteritis es alta. La rifaximina fue activa contra el 99-100% de las bacterias en concentraciones alcanzables en el contenido intestinal con las dosis recomendadas.

  12. Nitric oxide switches on glycolysis through the AMP protein kinase and 6-phosphofructo-2-kinase pathway

    OpenAIRE

    Almeida Parra, Ángeles; Moncada, Salvador; Bolaños Hernández, Juan Pedro

    2004-01-01

    El óxido nítrico activa la glucolisis en los astrocitos a través de una cascada de señalización en la que interviene la AMP kinasa, que fosforila (y activa) la fosfofructokinasa-2, enzima responsable de la biosíntesis de fructosa-2, 6-bisfosfato, efector alostérico positivo de la fosfofructokinasa-1. Este mecanismo es citoprotector.

  13. The correlation of acute toxicity and late rectal injury in radiotherapy for cervical carcinoma: Evidence suggestive of consequential late effect (CQLE)

    International Nuclear Information System (INIS)

    Wang, C.-J.; Leung, Stephen Wan; Chen, H.-C.; Sun, L.-M.; Fang, F.-M.; Huang, E.-Y.; Hsiung, C.-Y.; Changchien, C.-C.

    1998-01-01

    Purpose: To correlate the acute toxicity during pelvic irradiation and the development of late rectal injury following radiation therapy for cervical carcinoma. Methods and Materials: Two hundred and twenty patients treated with curative-intent radiation therapy between November 1987 and January 1992 were analyzed. Patients were treated initially with external beam irradiation, 40-44 Gy/20-22 fractions to whole pelvis, followed by high dose rate intracavitary brachytherapy, 7.2 Gy to point A for 3 fractions. Severity of diarrhea during radiation therapy was scored according to six criteria: fecal characteristics, frequency, onset, prescription of antidiarrheal agents, body weight loss during irradiation, and extramedical care needed. Patients were categorized as group ND (no obvious diarrhea), group MD (moderate diarrhea), and group SD (severe diarrhea) for sum score 0-1, 2-5, and ≥6, respectively. The rate of radiation proctitis was expressed, analyzed, and compared with actuarial proctitis-free rate and prevalence. Results: 1) According to the score, 76 (35%), 89 (40%), and 55 (25%) patients were categorized as group ND, group MD, and group SD, respectively. Distribution of patients and treatment characteristics among the three groups appeared similar. Patients treated with a larger field size, ≥16.5 cm 2 , tended to have increased severity of diarrhea. 2) Overall, 103 patients (47%, 103 of 220) developed radiation proctitis. Twenty-one patients were in group ND (28%, 21 of 76), 43 in group MD (48%, 43 of 89), and 39 in group SD (71%, 39 of 55). 3) The five-year actuarial proctitis-free rate was 72, 52, and 29% for group ND, MD, and SD, respectively (p s = 0.229, p = 0.098). 6) Cox's multivariate analysis revealed that severity of diarrhea was the only factor that significantly correlated with the development of radiation proctitis. Conclusion: Patients with increased acute toxicity and diarrhea during radiation therapy of cervical carcinoma significantly

  14. Normal tissue tolerance to external beam radiation therapy: Rectum; Dose de tolerance a l'irradiation des tissus sains: le rectum

    Energy Technology Data Exchange (ETDEWEB)

    Blanchard, P. [Departement de radiotherapie, institut Gustave-Roussy, 94 - Villejuif (France); Chapet, O. [Service d' oncologie-radiotherapie, centre hospitalier Lyon-Sud, 69 - Pierre-Benite (France)

    2010-07-15

    Radiation proctitis is among the most frequent radiation-induced toxicities. This is related to the high frequency of pelvic tumours and the key role of radiotherapy in the treatment of these tumours. Late rectal toxicity usually occurs within the first two years after the completion of a radiotherapy course. Rectal bleeding and a rectal syndrome are the main symptoms, and can be associated to fistulas or rectal ulcers. Clinical factors, such as diabetes mellitus, a severe acute radiation toxicity, small rectal volume or radiation hypersensitivity, are associated with late rectal toxicity. Dosimetric factors derived from the analysis of dose-volume histograms can also predict the occurrence of radiation proctitis, and help to adapt the prescribed dose and the ballistic of irradiation. (authors)

  15. Endomicroscopy for assessing mucosal healing in patients with ulcerative colitis.

    Science.gov (United States)

    Gheorghe, Cristian; Cotruta, Bogdan; Iacob, Razvan; Becheanu, Gabriel; Dumbrava, Mona; Gheorghe, Liana

    2011-12-01

    The assessment of tissue healing has emerged as an important treatment goal in patients with inflammatory bowel disease. In patients with ulcerative colitis (UC), mucosal healing may represent the ultimate therapeutic goal due to the fact that the inflammation is limited to the mucosal layer. Mucosal and histological healing may indicate a subset of UC patients in long-term clinical, endoscopic and histological remission in whom immunomodulators, biologics, and even aminosalicylates may be withdrawn. Confocal laser endomicroscopy allows the assessment of residual cellular inflammation, crypt and vessel architecture distortion during ongoing endoscopy, and therefore permits a real-time evaluation of histological healing in patients with ulcerative proctitis. Images of conventional optical microscopy and confocal laser endomicroscopy in patients with ulcerative proctitis in remission are presented.

  16. Prevalence of Adverse Effects Post-Brachytherapy on Women with Uterine Cervix Cancer in Durango, Mexico

    International Nuclear Information System (INIS)

    Herrera, Higmar; Yanez, Elvia; Deras, Diana C.; Reyes, Francianella

    2010-01-01

    This work aimed at determining the local prevalence of adverse effects on women with CaCu that recieved LDR brachytherapy treatment at CECAN. The data was extracted from the patient's and medical physics' departement records. Non Gaussian statistics was used due to dose distribution characteristics. A total of 103 patients were studied with average age of 55±13 years and Ia-IV FIGO clinical clasification. The observed prevalence is higher than that reported by other studies. It was observed that patients with proctitis were prescribed a slightly higher dose than those without adverse effects (90% confidence). Patients with proctitis also presented higher age (95% confidence) when compared with the mean of the studied population. The inverse applies to the group with other adverse effects, its average age is lower than the mean (90% confidence).

  17. Spectrum of rectal radiation lesions in cases of cancer cervix

    International Nuclear Information System (INIS)

    Srivastava, V.K.; Rohatgi, V.K.; Gupta, J.C.

    1978-01-01

    The study was carried out in 70 cases of carcinoma cervix uteri, showing varying degree of proctitis following radiotherapy treatment for cervical cancer. Grossly, the rectal mucosa showed oedema, congestion, granular proctitis, ulceration, and microscopically stromal connective tissue as well as epithelial changes. The stromal changes have been emphasised as useful diagnostic criteria of radiation reaction. The familarity of these changes is considered necessary because it is imperative to know categorically that a given lesion is entirely or in part due to radiation or due to extension of adjacent tumour in the cervix. Further, this issue is very important in management of cases of cancer cervix. The criteria of distinguishing the lesions in the rectal tissue have been laid down. (auth.)

  18. Hyperbaric oxygen - an effective tool to treat radiation morbidity in prostate cancer

    International Nuclear Information System (INIS)

    Mayer, Ramona; Klemen, Huberta; Quehenberger, Franz; Sankin, Oliver; Mayer, Elisabeth; Hackl, Arnulf; Smolle-Juettner, Freyja-Maria

    2001-01-01

    Purpose: We report the results of hyperbaric oxygen therapy (HBO) used in the treatment of radiation cystitis and proctitis following irradiation of prostate cancer. Materials and methods: Between June 1995 and March 2000, 18 men (median age 71 years) with radiation proctitis (n=7), cystitis (n=8), and combined proctitis/cystitis (n=3) underwent HBO therapy in a multiplace chamber for a median of 26 sessions (range 2-60). The treatment schedule (2.2-2.4 atmospheres absolute, 60 min bottom time, once-a-day, 7 days a week) was set at a lower limit of 20 sessions; the upper limit was left open to symptom-related adjustment. Prior to HBO treatment, RTOG/EORTC late genitourinal (GU) morbidity was Grade 2 (n=3), Grade 3 (n=6) or Grade 4 (n=2); modified RTOG/EORTC late gastrointestinal (GI) morbidity was either Grade 2 (n=4) or Grade 3 (n=6). Results: Sixteen patients underwent an adequate number of sessions. RTOG/EORTC late GU as well as modified GI morbidity scores showed a significant improvement after HBO (GI, P=0.004; GU, P=0.004; exact Wilcoxon signed rank test); bleeding ceased in five out of five patients with proctitis and in six out of eight patients with cystitis; one of those two patients, in whom an ineffective treatment outcome was obtained, went on to have a cystectomy. Conclusions: HBO treatment seems to be an effective tool to treat those patients with late GI and GU morbidity when conventional treatment has led to unsatisfactory results. Particularly in patients with radiation cystitis, HBO should not be delayed too long, as in the case of extensive bladder shrinkage improvement is hard to achieve

  19. Abdominal Computed tomography of 25 patients with AIDS or lymphadenopathy Syndrome

    International Nuclear Information System (INIS)

    Arrive, L.; Frija, J.; Couderc, L.J.; Clauvel, J.P.; Laval-Jeantet, M.; Matheron, S.

    1986-01-01

    An abdominal computed tomographic examination was performed to 20 patients with Acquired Immunodeficiency Syndrome (AIDS) and to 5 patients with Lymphadenopathy Syndrome (LAS). Intraabdominal lymph nodes were seen in 18 out of 20 cases of AIDS and in 5 cases of LAS. Lymph nodes have a normal size or are slightly enlarged but they are too numerous. Splenomegaly was found in 17 patients. Rectal modifications secondary to a proctitis were seen in the homosexual patients [fr

  20. Benign (solitary) ulcer of the rectum - another cause for rectal stricture

    Energy Technology Data Exchange (ETDEWEB)

    Chapa, H.J.; Smith, H.J.; Dickinson, T.A.

    1981-01-15

    Benign rectal ulcer syndrome is an uncommon cause of lower gastrointestinal bleeding. Patients may present with mild, often recurrent, rectal bleeding frequently ascribed to hemorrhoids. Barium enema may be normal during the early, nonulcerative phase of proctitis. Single (or multiple) ulcers with or without rectal stricture are the hallmarks of the radiographic diagnosis. Radiologic demonstration of the ulcer(s) is not required, however, for the diagnosis. Benign rectal ulcer should be included in the differential diagnosis of benign-appearing rectal strictures.

  1. Extraintestinal manifestations in Crohn's disease and ulcerative colitis

    DEFF Research Database (Denmark)

    Isene, Rune; Bernklev, Tomm; Høie, Ole

    2015-01-01

    BACKGROUND: In chronic inflammatory bowel disease (IBD) (Crohn's disease [CD] and ulcerative colitis [UC]), symptoms from outside the gastrointestinal tract are frequently seen, and the joints, skin, eyes, and hepatobiliary area are the most usually affected sites (called extraintestinal......, skin, and liver) manifestations: 20.1% versus 10.4% (p colitis compared to proctitis in UC increased the risk of EIM. CONCLUSION: In a European inception cohort, EIMs in IBD...

  2. 2014 UK national guideline for the management of anogenital herpes.

    Science.gov (United States)

    Patel, Raj; Green, John; Clarke, Emily; Seneviratne, Kanchana; Abbt, Naomi; Evans, Ceri; Bickford, Jane; Nicholson, Marian; O'Farrell, Nigel; Barton, Simon; FitzGerald, Mark; Foley, Elizabeth

    2015-10-01

    These guidelines concern the management of anogenital herpes simplex virus infections in adults and give advice on diagnosis, management, and counselling of patients. This guideline replaces the 2007 BASHH herpes guidelines and includes new sections on herpes proctitis, key points to cover with patients regarding transmission and removal of advice on the management of HSV in pregnancy which now has a separate joint BASHH/RCOG guideline. © The Author(s) 2015.

  3. Lymphogranuloma Venereum-Serovar L2b Presenting With Painful Genital Ulceration: An Emerging Clinical Presentation?

    Science.gov (United States)

    Haber, Roger; Maatouk, Ismaël; de Barbeyrac, Bertille; Bagot, Martine; Janier, Michel; Fouéré, Sébastien

    2017-05-01

    These 5 cases of atypical inflammatory lymphogranula venereum (LGV) serovar L2b presenting initially with edema and persistent painful ulceration illustrate that clinical manifestations of LGV in the current outbreak in men who have sex with men reflect the influence of both the serovars virulence and the host immune system and are not confined to proctitis. L2b serovar could have a particular high virulence profile, and the need for awareness of LGV as a cause of genital ulceration is crucial.

  4. Anorectal Lymphogranuloma Venereum in Madrid: A Persistent Emerging Problem in Men Who Have Sex With Men.

    Science.gov (United States)

    Cabello Úbeda, Alfonso; Fernández Roblas, Ricardo; García Delgado, Rosa; Martínez García, Laura; Sterlin, Fabiola; Fernández Guerrero, Manuel L; Górgolas, Miguel

    2016-07-01

    Since 2003, outbreaks of lymphogranuloma venereum (LGV) with anorectal syndrome have been increasingly recognized in many Western countries. All of them have been classified as LGV serovar L2b, mainly occurring in human immunodeficiency virus (HIV)-infected men who have had sex with men (MSM). We describe a series of 26 diagnosed cases of LGV proctitis in downtown Madrid, Spain, in 2014, after implementing routine diagnostic procedures for this disease in symptomatic MSM. We conducted an observational study of patients with symptomatic proctitis attending an outpatient infectious diseases clinic in Madrid, Spain during calendar year 2014. Clinical, epidemiological, laboratory, and therapeutic data were gathered and analyzed. Twenty-six patients were included in the analysis. All were MSM, and 24 of them were HIV-positive. All patients reported having acute proctitis symptoms including tenesmus (85%), pain (88%), constipation (62%), or anal discharge (96%). Proctoscopy showed mucopurulent exudate (25 patients [96%]), and rectal bleeding, with mucosal erythema and/or oedema in all cases. Rectal swabs were obtained from all patients, and LGV serovar L2 was confirmed in all of them. The cure rate was 100% after standard treatments with doxycycline 100 mg twice per day for 3 weeks. Simultaneous rectal infections with other sexually transmitted pathogens (gonorrhoea, herpes simplex virus, Mycoplasma genitalium) and systemic sexually transmitted diseases (STDs) (syphilis, acute HIV, and hepatitis C infections) were also documented in 12 patients (46%), but these co-infections did not appear to influence the clinical manifestations of LGV. Anorectal LGV is a common cause of acute proctitis and proctocolitis among HIV-infected MSM who practice unprotected anal sex, and it is frequently associated with other rectal STDs. The implementation of routine screening and prompt diagnosis of these rectal infections should be mandatory in all clinical settings attended by HIV and STD

  5. Catalog of Completed Studies, US Army Health Care Studies and Clinical Investigation Activity.

    Science.gov (United States)

    1984-12-10

    Arch. Dermatol, 1980, 116:559-561. 16 Becker, L. E. Charles, C. R., Babcock, W. S., Electrol microscopic diagnosis of lymphogranuloma venereum , J. Assn...852. 3 Becker, L. E., Skipworth, G. B., Ginkgo-tree dermatitis, stomatitis, and proctitis. JAMA, 1975, 231:1162-1163. 4 Becker, L. E., Lymphogranuloma ... venereum . Intl. J. Dermatol, 1976, 15:26-33 5 Jessen, R. T., Straight, M., Becker, L. E., Lichen myxedematosus. Treatment with cyclophosphamide. Int

  6. Sensory and motor dysfunction assessed by anorectal manometry in uterine cervical carcinoma patients with radiation-induced late rectal complication

    International Nuclear Information System (INIS)

    Kim, Gwi Eon; Lim, John Jihoon; Park, Won; Park, Hee Chul; Chung, Eun Ji; Seong, Jinsil; Suh, Chang Ok; Lee, Yong Chan; Park, Hyo Jin

    1998-01-01

    Purpose: To investigate the effects of radiation on anorectal function in patients with carcinoma of the uterine cervix. Methods and Materials: Anorectal manometry was carried out on 24 patients (complication group) with late radiation proctitis. All of the manometric data from these patients were compared with those from 24 age-matched female volunteers (control group), in whom radiation treatment had not yet been performed. Results: Regardless of the severity of proctitis symptoms, 25% of patients demonstrated all their manometric data within the normal range, but 75% of patients exhibited one or more abnormal manometric parameters for sensory or motor functions. Six patients (25%) had an isolated sensory dysfunction, eight patients (33.3%) had an isolated motor dysfunction, and four patients (16.7%) had combined disturbances of both sensory and motor functions. The maximum tolerable volume, the minimal threshold volume, and the urgent volume in the complication group were significantly reduced compared with those in the control group. The mean squeeze pressure in the complication group was significantly reduced, whereas the mean resting pressure and anal sphincter length were unchanged. Conclusions: Physiologic changes of the anorectum in patients with late radiation proctitis seem to be caused by a variety of sensory and/or motor dysfunctions in which many different mechanisms are working together. The reduced rectal reservoir capacity and impaired sensory functions were crucial factors for functional disorder in such patients. In addition, radiation damage to the external anal sphincter muscle was considered to be an important cause of motor dysfunction

  7. Lymphogranuloma Venereum 2015: Clinical Presentation, Diagnosis, and Treatment.

    Science.gov (United States)

    Stoner, Bradley P; Cohen, Stephanie E

    2015-12-15

    Lymphogranuloma venereum (LGV) has emerged as an important cause of proctitis and proctocolitis in men who have sex with men; classical inguinal presentation is now increasingly uncommon. We report summary findings of an extensive literature review on LGV clinical presentation, diagnosis, and treatment that form the evidence base for the 2015 Centers for Disease Control and Prevention treatment guidelines for sexually transmitted diseases. Proctitis and proctocolitis are now the most commonly reported clinical manifestations of LGV, with symptoms resembling those of inflammatory bowel disease. Newer molecular tests to confirm LGV infection are sensitive and specific, but are generally restricted to research laboratory or public health settings. Doxycycline (100 mg twice daily for 21 days) remains the treatment of choice for LGV. Patients with rectal chlamydial infection and signs or symptoms of proctitis should be tested for LGV, or if confirmatory testing is not available, should be treated empirically with a recommended regimen to cover LGV infection. © The Author 2015. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  8. Lymphogranuloma venereum: an old, forgotten re-emerging systemic disease.

    Science.gov (United States)

    Dal Conte, I; Mistrangelo, M; Cariti, C; Chiriotto, M; Lucchini, A; Vigna, M; Morino, M; Di Perri, G

    2014-03-01

    Lymphogranuloma venereum (LGV) is a sexually transmitted infection endemic in parts of Africa, Asia, South America, and the Caribbean, but once was rarely observed in Western countries, where most cases were considered to be imported. However, recent outbreaks have been reported in Europe, Australia, New Zealand, the United States and Canada, mainly among HIV positive men who have sex with men, signaling LGV re-emergence. The etiological agent of LGV is Chlamydia trachomatis serotypes L1, L2 and L3, and current outbreaks are mostly sustained by L2b type. The clinical course can be classically divided into three stages: an initial papule, which may ulcerate at the site of inoculation, followed by regional lymphoadenopathy (second stage, generally unilateral). In the tertiary stage, lymphatic obstruction, with elephantiasis of genitalia, and rectal involvement can lead to the formation of strictures and fistulae that may require surgical treatment. Recent cases are observed mainly among HIV positive people, often co-infected with HCV and others STIs, engaging in high-risk sexual practices. The main clinical picture is a relative new entity characterized by progressive ulcerative proctitis, the so called anorectal syndrome. Diagnosis is often delayed, requires a high index of clinical suspicion and must rely on the use of nucleic acid amplification tests. The differential diagnosis of proctitis should include LGV infection. Gastroenterologists, coloproctologists, dermatologists and other specialists need to be aware of LGV proctitis to avoid diagnostic delay and progression of disease to the tertiary stage.

  9. Policitemia vera: associação entre enfartes cerebrais e úlceras gástricas

    Directory of Open Access Journals (Sweden)

    Tiago Borges

    2017-09-01

    A PV é uma neoplasia mieloproliferativa crónica cujo curso clínico se caracteriza frequentemente por fenómenos trombóticos. O diagnóstico ocorre na sequência de tromboses em cerca de 30% dos casos, sendo que os eventos arteriais e cerebrovasculares são mais frequentes. Em contrapartida, a associação com doença ulcerosa péptica não é tão linear mas a positividade para Helicobacter pylori e a hemorragia gastrointestinal foram descritas como mais prevalentes em doentes com neoplasias mieloproliferativas. Especificamente nos doentes com PV e como ilustrado neste caso, a presença de ferropenia ou microcitose pode indiciar esta associação, sendo porventura pertinente uma vigilância dos doentes com PV relativamente ao atingimento gastroduodenal.

  10. Diversidad y universalidad como respuesta a pie diabético en paciente paquistaní con diabetes mellitus tipo 2 desde Atención Primaria

    Directory of Open Access Journals (Sweden)

    Montserrat Brugada Faura

    Full Text Available Siguiendo las enseñanzas de Madeleine Leininger sobre los conceptos de su modelo transcultural, buscamos una respuesta en el entorno de la Atención Primaria al caso que nos ocupa de una lesión ulcerosa en pie izquierdo, de etiología desconocida, en paciente paquistaní con diabetes mellitus tipo 2. Hallando la respuesta mediante la adaptación de similitudes de riesgo en el entorno de esta enfermedad, comunes en todas las culturas, y cuyas diferencias estriban en la localización de la úlcera y su factor desencadenante. Anómalas en nuestra cultura al estar relacionada con sus prácticas culturales.

  11. Efficiency of Intraligamentary Anesthesia of Inferior Molars for Endodontic Treatment

    Directory of Open Access Journals (Sweden)

    Peycheva K.

    2014-12-01

    Full Text Available The periodontal ligament injection appears to be the most consistently reliable in achieving clinically adequate pulpal anaesthesia. Materials and Methods: 130 inferior molar teeth; technique: The tooth was first cleaned with chlorhexidine 0.2% solution. The penetration of the ligament is performed with special intraligamentary needle (30 G - 9, 17,21 mm “sliding” along the side of the tooth, 300º angle between the needle and the tooth, having taken the care of determining support points which will prevent the needle from twisting. The penetration must be deep enough to obtain the seal required for the injection, injection for each root in particular points; volume of solution per root is 0.2-0.4 ml. Results: In 125 cases the technique was absolutely efficient. In only 5 cases with pulpitis chronica ulcerosa there was need for additional intrapulpal anesthesia. Conclusions: The method could be used as a primary anesthetic method for endodontic treatment.

  12. Patología colorrectal

    Directory of Open Access Journals (Sweden)

    Dr. M. Raúl Acuña

    2014-01-01

    Full Text Available En este artículo se abordan las patologías colorrectales más prevalentes en relación a la salud del hombre. Dado lo extenso del tema se han excluído aquellas patologías que comprometiendo este segmento del aparato digestivo también involucran otras áreas de este mismo sistema. Por este motivo nos centraremos en los siguientes problemas: enfermedad diverticular de colon, enfermedades inflamatorias intestinales (colitis ulcerosa idiopática y enfermedad de Crohn, alteraciones por isquemia y compromiso secundario a radioterapia de este segmento del aparato digestivo. El cáncer colorrectal, patología de alta relevancia, no se desarrollará pues recientemente fue revisado en un número de esta misma revista.

  13. Estado actual del tratamiento quirúrgico de la úlcera péptica perforada en el Hospital Regional de Talca: Experience of a regional hospital

    OpenAIRE

    Butte B, Jean Michel; Dagnino U, Bruno; Tapia V, Alvaro; Llanos L, Jorge

    2007-01-01

    La perforación de una úlcera péptica corresponde a una infrecuente y siempre grave complicación de la enfermedad ulcerosa. El tratamiento quirúrgico es la terapia de elección. Se operaron 22 pacientes (21 hombres) con una edad promedio de 50 años. Tres enfermos tenían el diagnóstico de úlcera péptica previo a la emergencia actual. El síntoma más frecuente de consulta fue el dolor epigástrico de inicio súbito en 21 (95,4%) pacientes. El diagnóstico se realizó con radiografía de tórax de pie o ...

  14. La definición de usos del suelo en las cercanías de fallas geológicas: explicación del Protocolo Técnico del Decreto Ejecutivo 32967 - MINAE, Anexo 3

    OpenAIRE

    Allan Astorga-Gätgens

    2013-01-01

    Se realiza una explicación técnica sobre el Protocolo Técnico publicado como Decreto Ejecutivo (32967 - MINAE, Anexo 3). El Protocolo se refiere a la definición de los usos del suelo en las cercanías de fallas geológicas inactivas, activas y potencialmente activas. Aparte de aclarar la nomenclatura técnica, se explica el procedimiento que debe seguir el profesional en geología para establecer las eventuales zonas de seguridad que deben respetarse al momento de definir los usos del suelo, en p...

  15. Materiales piezoeléctricos: formas de presentación ventajas y desventajas en las aplicaciones

    OpenAIRE

    Jiménez, B.

    1995-01-01

    El enorme desarrollo que han experimentado las aplicaciones de los materiales piezoeléctricos en las nuevas tecnologías se ha debido, fundamentalmente, al descubrimiento de las propiedades ferroeléctricas en los materiales con estructura tipo perovskita de composiciones basadas en el Titanato de Plomo. La posibilidad de preparar soluciones sólidas en forma cerámica y más recientemente el polímero PVDF y los materiales compuestos por una fase activa piezoeléctrica y otra fase no activa , "comp...

  16. GRAFITIS: MUCHO MÁS QUE OVARIOS Y TESTÍCULOS. UNA PROPUESTA DE TRABAJO PARA DOCENTES Y ESTUDIANTES

    Directory of Open Access Journals (Sweden)

    Francisco González García

    2016-10-01

    se propone una secuencia de actividades para trabajar la sexualidad con un material universalmente conocido, los grafitis. Se trata de una serie de sugerencias adaptables, según la sensibilidad y la creatividad del profesorado y del alumnado que las desarrolle con las podemos deducir las manifestaciones activas de las experiencias sexuales, reales o imaginativas de esa juventud.

  17. Sección medicina legal: conferencia inaugural en el curso de legislación farmacéutica

    Directory of Open Access Journals (Sweden)

    Guillermo Uribe Cualla

    1933-04-01

    prescribir una terapéutica activa, y otra cosa distinta el papel. del farmacéutico que nada tiene que hacer con la clínica y sí mucho con los conocimientos en terapéutica, toxicología, materia médica, química analítica, botánica, etc.

  18. Seroprevalencia de la enfermedad de Chagas y factores de riesgo asociados en una población de Morroa, Sucre

    Directory of Open Access Journals (Sweden)

    Richard Hoyos

    2007-01-01

    Conclusiones. Nuestros resultados indican que la zona estudiada presenta elementos de riesgo para el establecimiento de un ciclo de transmisión activa, se hace necesario verificar la presencia de triatominos en la zona de estudio y establecer medidas para prevenir la presencia de la enfermedad de Chagas en el área de Morroa, Sucre.

  19. Cambios en las diferencias por sexo en la esperanza de vida en España (1980-2012: descomposición por edad y causa

    Directory of Open Access Journals (Sweden)

    Juan Manuel García González

    2018-03-01

    Conclusiones: La diferencia en la esperanza de vida entre hombres y mujeres ha disminuido desde 1995, debido a la mejora en la mortalidad por causas de muerte asociadas a conductas y hábitos de riesgo de la población masculina en edad activa.

  20. Mecanismos de defensa en las interacciones planta-patógeno

    DEFF Research Database (Denmark)

    Madriz-Ordeñana, Kenneth

    1998-01-01

    ésto. Las in- teracciones planta-patógeno pueden presentar varios tipos de asociaciones, que dependen en gran parte del contenido genético de cada organismo. La resistencia inducida es una forma de defensa activa que involucra la expresión diferencial de genes y cambios metabólicos que ocurren como...

  1. Lg and Other Regional Phases in South America

    Science.gov (United States)

    1992-10-01

    Colombiana de Ciencias Exactas Fisicas y Naturales XIII, 227-235. Ramirez E. (1947). Mapa sisnico y tect6nico de Colombia, ed. Instituto Geofisico de...BrasiLero 15 F % Fat Las y Lineamientos asumiidos / Fatlas con actividad j probable Fat las Activas rN % Fattas Inversas ’ A ft G E M4 T’ 14 A Fattas

  2. Nasal Colonization with Methicillin-Resistant Staphylococcus aureus in Military Personnel in a Developing Country - Development of a Skin and Soft Tissue Infection Surveillance System in the Peruvian Air Force

    Science.gov (United States)

    2015-04-07

    infecciones de piel y tejidos blandos (IPTB) en la población militar activa de la Fuerza Aérea del Perú. III. Materiales y Métodos COMPONENTE 1...complete un cuestionario de seguimiento y se le tomo nuevos hisopados nasales en cada visita. Cada hisopado nasal fue cultivado y se identifico

  3. Fulltext PDF

    Indian Academy of Sciences (India)

    Nana Wang et al. As an unstable nitrogenous cumulene, ketenimine can react with unsaturated compounds to form heterocyclic compounds. Liu et al., investigated the cycloaddition reaction between ketenimine and cyclo- pentadiene theoretically, establishing that the activa- tion energy for this reaction is 156.5kJ/mol using.

  4. El uso del lenguaje en la resolución de conflicto

    OpenAIRE

    Ginés Romero, Vicent

    2016-01-01

    Análisis de la influencia del lenguaje en la resolución de conflictos en relación a la competencia comunicativa de los implicados y mediadores. Trabajando las habilidades sociales de asertividad y escucha activa en función de la responsabilidad de los implicados en el conflicto.

  5. Promoción y desarrollo humano: su relación actual con el trabajo social en salud

    Directory of Open Access Journals (Sweden)

    Nora Eugenia Muñoz Franco

    2007-01-01

    Full Text Available En este artículo se dimensiona la intervención de trabajo social en el área de la salud desde la promoción, considerada como práctica social que desencadena procesos de autogestión en las colectividades para participar de manera activa en su desarrollo so

  6. Johan Bülows spade

    DEFF Research Database (Denmark)

    Knudsen, Karin Esmann

    2017-01-01

    practice. The paradise of the garden is the place of care (Robert Pugue Harrison 2008). This chapter examines how the ideas of vita activa (Hanna Arendt 1958) occur in the eighteenth century in 'how-to' gardening books and in the practice of the Danish garden enthusiast Johan Bülow, who created the garden...

  7. Pressure effect on rate of production of glucose-equivalent in plant ...

    Indian Academy of Sciences (India)

    Administrator

    C4 Green plants; rate of equivalent production; pressure effect. 1. Introduction ... the photosynthetic process, especially on the activa- tion and ... Section 4 deals with the effect ... the global concentrations of glyceraldehydes-3- ... chloroplast,9a a product of the maximum possible .... as soil, tissue, development stage, etc.

  8. REVIEW (AND PERSONAL REFLECTIONS ON THE BOOK: Immigration and active citizenship. Contributions concerning participatory governance and social inclusion

    Directory of Open Access Journals (Sweden)

    Tomás Alberich

    2014-06-01

    Full Text Available Reseña (y reflexiones personales sobre el libro: Inmigración y ciudadanía activa. Contribuciones sobre gobernanza participativa e inclusión social. Coordinado por Enrique Raya, Angeles Espadas y Mourad Aboussi. Icaria Editorial, 2013. 

  9. Caspase-8 Binding to Cardiolipin in Giant Unilamellar Vesicles Provides a Functional Docking Platform for Bid

    DEFF Research Database (Denmark)

    Jalmar, Olivier; Franc¸ois-Moutal, Liberty; García-Sáez, Ana-Jesus

    2013-01-01

    Caspase-8 is involved in death receptor-mediated apoptosis in type II cells, the proapoptotic programme of which is triggered by truncated Bid. Indeed, caspase-8 and Bid are the known intermediates of this signalling pathway. Cardiolipin has been shown to provide an anchor and an essential activa...

  10. Política económica y desarrollo del sistema financiero peruano, parte II: propuesta para una reforma y análisis de la nueva ley de bancos.

    OpenAIRE

    Armando Caceres; Javier Nagamine

    1992-01-01

    El documento propone, a partir de la problemática del sistema financiero, revisada en la primera parte de este estudio, modificaciones en el entorno económico que enfrentan las empresas financieras, así como una participación activa del Estado en la supervisión y control de las entidades crediticias.

  11. Hannah Arendt and Norwegian Muslim Children's Schooling: In Pursuit of Democratic Practices

    Science.gov (United States)

    Giaever, Katrine; Jones, Liz

    2017-01-01

    The aim of this paper is to consider whether Hannah Arendt's (1996) [Arendt, H. (1958/1998). "Vita Activa. The Human Condition." Chicago: University of Chicago] concept of "public space" is a potentially useful and creative way of thinking about aspects of Muslim children's experiences within the context of education. Following…

  12. On Practising in Physical Education: Outline for a Pedagogical Model

    Science.gov (United States)

    Aggerholm, K.; Standal, O.; Barker, D. M.; Larsson, H.

    2018-01-01

    Background: Models-based approaches to physical education have in recent years developed as a way for teachers and students to concentrate on a manageable number of learning objectives, and align pedagogical approaches with learning subject matter and context. This paper draws on Hannah Arendt's account of "vita activa" to map existing…

  13. Calidad del registro del diagnóstico de demencia en atención primaria. La situación en España en el periodo 2002-2011

    Directory of Open Access Journals (Sweden)

    María del Canto de Hoyos-Alonso

    2016-01-01

    Conclusiones: Casi la mitad de los pacientes con anticolinesterásicos o memantina no tienen registrado diagnóstico de demencia en su HCE-AP. El registro mejora al aumentar el tiempo de seguimiento. Se requieren mejoras de la HCE-AP, coordinación asistencial adecuada y actitud activa para aumentar la calidad del registro de demencia.

  14. Metodologia participativa a l'aula universitaria : la participació de l'alumnat

    OpenAIRE

    Imbernón, Francesc; Medina, José Luis (Medina Moya)

    2005-01-01

    [spa] La motivación y la participación activa del alumnado son elementos fundamentales de los procesos de aprendizaje. Este cuaderno aspira a contribuir a la investigación de nuevas vías de acceso al conocimiento en situaciones que favorezcan la participación.

  15. Outcomes After Intensity-Modulated Versus Conformal Radiotherapy in Older Men With Nonmetastatic Prostate Cancer

    International Nuclear Information System (INIS)

    Bekelman, Justin E.; Mitra, Nandita; Efstathiou, Jason; Liao Kaijun; Sunderland, Robert; Yeboa, Deborah N.; Armstrong, Katrina

    2011-01-01

    Purpose: There is little evidence comparing complications after intensity-modulated (IMRT) vs. three-dimensional conformal radiotherapy (CRT) for prostate cancer. The study objective was to test the hypothesis that IMRT, compared with CRT, is associated with a reduction in bowel, urinary, and erectile complications in elderly men with nonmetastatic prostate cancer. Methods and Materials: We undertook an observational cohort study using registry and administrative claims data from the SEER-Medicare database. We identified men aged 65 years or older diagnosed with nonmetastatic prostate cancer in the United States between 2002 and 2004 who received IMRT (n = 5,845) or CRT (n = 6,753). The primary outcome was a composite measure of bowel complications. Secondary outcomes were composite measures of urinary and erectile complications. We also examined specific subsets of bowel (proctitis/hemorrhage) and urinary (cystitis/hematuria) events within the composite complication measures. Results: IMRT was associated with reductions in composite bowel complications (24-month cumulative incidence 18.8% vs. 22.5%; hazard ratio [HR] 0.86; 95% confidence interval [CI], 0.79–0.93) and proctitis/hemorrhage (HR 0.78; 95% CI, 0.64–0.95). IMRT was not associated with rates of composite urinary complications (HR 0.93; 95% CI, 0.83–1.04) or cystitis/hematuria (HR 0.94; 95% CI, 0.83–1.07). The incidence of erectile complications involving invasive procedures was low and did not differ significantly between groups, although IMRT was associated with an increase in new diagnoses of impotence (HR 1.27, 95% CI, 1.14–1.42). Conclusion: IMRT is associated with a small reduction in composite bowel complications and proctitis/hemorrhage compared with CRT in elderly men with nonmetastatic prostate cancer.

  16. Notes from the Field: Increase in Neisseria meningitidis-Associated Urethritis Among Men at Two Sentinel Clinics - Columbus, Ohio, and Oakland County, Michigan, 2015.

    Science.gov (United States)

    Bazan, Jose A; Peterson, Amy S; Kirkcaldy, Robert D; Briere, Elizabeth C; Maierhofer, Courtney; Turner, Abigail Norris; Licon, Denisse B; Parker, Nicole; Dennison, Amanda; Ervin, Melissa; Johnson, Laura; Weberman, Barbara; Hackert, Pamela; Wang, Xin; Kretz, Cecilia B; Abrams, A Jeanine; Trees, David L; Del Rio, Carlos; Stephens, David S; Tzeng, Yih-Ling; DiOrio, Mary; Roberts, Mysheika Williams

    2016-06-03

    Neisseria meningitidis (Nm) urogenital infections, although less common than infections caused by Neisseria gonorrhoeae (Ng), have been associated with urethritis, cervicitis, proctitis, and pelvic inflammatory disease. Nm can appear similar to Ng on Gram stain analysis (gram-negative intracellular diplococci) (1-5). Because Nm colonizes the nasopharynx, men who receive oral sex (fellatio) can acquire urethral Nm infections (1,3,5). This report describes an increase in Nm-associated urethritis in men attending sexual health clinics in Columbus, Ohio, and Oakland County, Michigan.

  17. Benign (solitary) ulcer of the rectum - another cause for rectal stricture

    International Nuclear Information System (INIS)

    Chapa, H.J.; Smith, H.J.; Dickinson, T.A.; Veterans Administration Hospital, Dallas, TX; Texas Univ., Dallas

    1981-01-01

    Benign rectal ulcer syndrome is an uncommon cause of lower gastrointestinal bleeding. Patients may present with mild, often recurrent, rectal bleeding frequently ascribed to hemorrhoids. Barium enema may be normal during the early, nonulcerative phase of proctitis. Single (or multiple) uclers with or without rectal stricture are the hallmarks of the radiographic diagnosis. Radiologic demonstration of the ulcer(s) is not required, however, for the diagnosis. Benign rectal ulcer should be included in the differential diagnosis of benign-appearing rectal strictures. (orig.) [de

  18. Two for One: Coexisting Ulcerative Colitis and Crohn’s Disease

    Directory of Open Access Journals (Sweden)

    Grant I Chen

    2002-01-01

    Full Text Available Three cases of coexisting ulcerative colitis and Crohn’s disease are presented. In the first case, the patient had a long-standing history of ulcerative proctitis before developing Crohn’s colitis. In the two remaining cases, the patients presented initially with Crohn’s disease of the ileum and, subsequent to resection, developed ulcerative colitis. Well-documented cases of patients diagnosed with both ulcerative colitis and Crohn’s disease are rare. The literature on such cases is reviewed, and the controversy over whether ulcerative colitis and Crohn’s disease are two distinct diseases is explored.

  19. Lymphogranuloma venereum detected from the pharynx in four London men who have sex with men.

    Science.gov (United States)

    Dosekun, O; Edmonds, S; Stockwell, S; French, P; White, J A

    2013-06-01

    Lymphogranuloma venereum (LGV) is an established cause of proctitis in men who have sex with men (MSM). Currently in the UK, testing for pharyngeal Chlamydia trachomatis (CT) is not routine, and LGV typing is usually only performed in patients with anorectal symptoms. We report four cases where LGV-associated CT DNA was detected from the pharynx in MSM, demonstrating that nucleic acid amplification testing (NAAT) can be used for detecting and typing pharyngeal CT infection. These cases also highlight other possible routes of infection for LGV, and add to the broad spectrum of clinical presentations associated with this infection.

  20. [Lymphogranuloma venereum. An old disease in a new dress].

    Science.gov (United States)

    de Roche, M; Sawatzki, M; Degen, L; Itin, P; Flückiger, U; Frei, R; Goldenberger, D

    2011-05-01

    Lymphogranuloma venereum is a sexually transmitted disease caused by Chlamydia trachomatis, serotypes L1, L2 and L3. The classical clinical manifestation is a painful inguinal lymphadenopathy, resulting without treatment in severe complications. Over the last years, however, the emergence of massive ulcerative proctitis has been observed, especially in men who have sex with men. Because the clinical symptoms are unspecific, Chlamydia trachomatis should actively be looked for. Reliable and rapid molecular tests have now been established to diagnose lymphogranuloma venereum. The therapeutic recommendation is tetracycline for 3 weeks. We present 5 cases to illustrate this disease.

  1. Argon plasma coagulation for rectal bleeding after prostate brachytherapy

    International Nuclear Information System (INIS)

    Smith, Stephen; Wallner, Kent; Dominitz, Jason A.; Han, Ben; True, Lawrence; Sutlief, Steven; Billingsley, Kevin

    2001-01-01

    Purpose: To better define the efficacy and safety of argon plasma coagulation (APC), specifically for brachytherapy-related proctitis, we reviewed the clinical course of 7 patients treated for persistent rectal bleeding. Approximately 2-10% of prostate cancer patients treated with 125 I or 103 Pd brachytherapy will develop radiation proctitis. The optimum treatment for patients with persistent bleeding is unclear from the paucity of available data. Prior reports lack specific dosimetric information, and patients with widely divergent forms of radiation were grouped together in the analyses. Methods and Materials: Seven patients were treated with APC at the Veterans Affairs Puget Sound Health Care System and the University of Washington from 1997 to 1999 for persistent rectal bleeding due to prostate brachytherapy-related proctitis. Four patients received supplemental external beam radiation, delivered by a four-field technique. A single gastroenterologist at the Veterans Affairs Puget Sound Health Care System treated 6 of the 7 patients. If the degree of proctitis was limited, all sites of active bleeding were coagulated in symptomatic patients. An argon plasma coagulator electrosurgical system was used to administer treatments every 4-8 weeks as needed. The argon gas flow was set at 1.6 L/min, with an electrical power setting of 40-45 W. Results: The rectal V100 (the total rectal volume, including the lumen, receiving the prescription dose or greater) for the 7 patients ranged from 0.13 to 4.61 cc. Rectal bleeding was first noticed 3-18 months after implantation. APC (range 1-3 sessions) was performed 9-22 months after implantation. Five patients had complete resolution of their bleeding, usually within days of completing APC. Two patients had only partial relief from bleeding, but declined additional APC therapy. No patient developed clinically evident progressive rectal wall abnormalities after APC, (post-APC follow-up range 4-13 months). Conclusions: Most

  2. [A Case of Rectal Syphilis Incidentally Found at Regular Medical Check-up].

    Science.gov (United States)

    You, Ji Hong; Cho, Ki Won; Cha, Yoon Jin; Park, Hyo Jin

    2016-10-25

    Syphilis is a rare disease in the rectum. It is difficult to diagnose because the characteristics of the rectal syphilis rectal lesion are highly varied. The endoscopic findings of rectal syphilis are proctitis, ulcers, and masses. If rectal syphilis is suspected to be the cause for rectal lesions, it is important for physicians to consider the sexual history and sexual orientation of the patient. We report a case of incidental rectal syphilis in a 41-year-old man diagnosed during a regular medical check-up.

  3. Changes in clinical characteristics, course, and prognosis of inflammatory bowel disease during the last 5 decades: a population-based study from Copenhagen, Denmark

    DEFF Research Database (Denmark)

    Jess, Tine; Riis, Lene; Vind, Ida

    2007-01-01

    Copenhagen, Denmark (1962-2005), were assessed and evaluated. METHODS: Phenotype, initial disease course, use of medications, cumulative surgery rate, standardized incidence ratio of colorectal cancer (CRC), and standardized mortality ratio (SMR) were compared in the 3 cohorts, which had a total of 641.......01). The prevalence of upper gastrointestinal involvement and pure colonic CD varied significantly between cohorts. UC patients diagnosed in the 1990s had a higher prevalence of proctitis, received more medications, and had a milder initial disease course than did previous patients. The surgery rate decreased...

  4. Chromosome Damage and Cell Proliferation Rates in In Vitro Irradiated Whole Blood as Markers of Late Radiation Toxicity After Radiation Therapy to the Prostate

    Energy Technology Data Exchange (ETDEWEB)

    Beaton, Lindsay A., E-mail: Lindsay.Beaton@hc-sc.gc.ca [Environmental and Radiation Health Sciences Directorate, Health Canada, Ottawa, ON (Canada); Ferrarotto, Catherine; Marro, Leonora [Environmental and Radiation Health Sciences Directorate, Health Canada, Ottawa, ON (Canada); Samiee, Sara; Malone, Shawn; Grimes, Scott; Malone, Kyle [The Ottawa Hospital, Ottawa Hospital Research Institute, University of Ottawa, 501 Smyth Rd, Ottawa, ON (Canada); Wilkins, Ruth C. [Environmental and Radiation Health Sciences Directorate, Health Canada, Ottawa, ON (Canada)

    2013-04-01

    Purpose: In vitro irradiated blood samples from prostate cancer patients showing late normal tissue damage were examined for lymphocyte response by measuring chromosomal aberrations and proliferation rate. Methods and Materials: Patients were selected from a randomized trial evaluating the optimal timing of dose-escalated radiation and short-course androgen deprivation therapy. Of 438 patients, 3% experienced grade 3 late radiation proctitis and were considered to be radiosensitive. Blood samples were taken from 10 of these patients along with 20 matched samples from patients with grade 0 proctitis. The samples were irradiated at 6 Gy and, along with control samples, were analyzed for dicentric chromosomes and excess fragments per cell. Cells in first and second metaphase were also enumerated to determine the lymphocyte proliferation rate. Results: At 6 Gy, there were statistically significant differences between the radiosensitive and control cohorts for 3 endpoints: the mean number of dicentric chromosomes per cell (3.26 ± 0.31, 2.91 ± 0.32; P=.0258), the mean number of excess fragments per cell (2.27 ± 0.23, 1.43 ± 0.37; P<.0001), and the proportion of cells in second metaphase (0.27 ± 0.10, 0.46 ± 0.09; P=.0007). Conclusions: These results may be a valuable indicator for identifying radiosensitive patients and for tailoring radiation therapy.

  5. Carcinoma of the prostate treated by pelvic node dissection, iodine-125 seed implant and external irradiation; a study of rectal complications

    Energy Technology Data Exchange (ETDEWEB)

    Abadir, R.; Ross, G. Jr.; Weinstein, S.H. (Missouri Univ., Columbia (USA). Hospital and Clinics)

    1984-09-01

    The University of Missouri-Columbia protocol for localised cancer of the prostate calls for pelvic node dissection, 10 000 cGy at the periphery of the prostate from /sup 125/I and 4000 cGy in 20 fractions to the whole pelvis using supervoltage X-ray therapy. Rectal complications were studied in 104 patients; acute and chronic reactions were defined. During external irradiation 54% did not develop diarrhoea, 43% had mild diarrhoea and 3% had severe diarrhoea. In the chronic stage 77% did not have diarrhoea, 12% had delayed, non-distressing rectal bleeding which did not need specific treatment or needed only simple treatment, 7% had prolonged distressing proctitis and 4% had rectal ulceration or recto-urethral fistula necessitating colostomy. Each of the four patients who had colostomy had an additional aetiological factor (arterial disease, pelvic inflammation, additional radiation, pelvic malignancy or second operation). None of the patients entered in the combined brachytherapy and teletherapy programme, and in whom 0.5 cm space was maintained between the closest seed and the rectal mucosa, developed prolonged proctitis.

  6. Lymphogranuloma venereum among patients presenting at the HIV/STI clinic in Antwerp, Belgium : a case series.

    Science.gov (United States)

    Apers, Ludwig; Florence, Eric; Crucitti, Tania; Anwar, Nabila

    2017-01-01

    Objective of this study was to describe the patient characteristics and clinical presentation of laboratory confirmed lymphogranuloma venereum (LGV) cases, diagnosed at the Institute of Tropical Medicine (ITM), Antwerp, Belgium. Demographic and biomedical characteristics of all patients with chlamydia-positive sample results were retrieved for the years 2013 and 2014. Samples were obtained from both symptomatic and asymptomatic patients who consulted at the HIV/STI clinic. Fifty four patients with laboratory confirmed LGV were detected among 3885 nucleic acid amplification tests (NAATs) performed for the detection of chlamydia during the two years under review. Fifty three were men and equally fifty three had sex with men only (MSM). HIV (87%) and HCV (31.5%) were common concomitant infections, whilst anal gonorrhoea and syphilis were detected at the moment of the LGV diagnosis among 19 (35.2%) and 6 (11.0%) cases respectively. All cases were symptomatic, except one. The most frequent symptoms that were recorded could be categorised as proctitis (in 40 patients (74%)). Lymphadenopathy, anal and genital ulcers were signs that were present in 7 (13.0%), 4 (7.4%) and 2 patients (3.7%) respectively. LGV remains an important sexually transmitted disease among MSM. In this retrospective study, the far majority of LGV was detected amongst symptomatic persons. HCV, HIV, anal gonorrhoea and syphilis were associated co-infections. Proctitis in a high risk patient should alert the clinician for the possibility of an STI. © Acta Gastro-Enterologica Belgica.

  7. Sexually Transmitted Infections: Experience in a Multidisciplinary Clinic in a Tertiary Hospital (2010-2013).

    Science.gov (United States)

    Moreno-Ribera, N; Fuertes-de Vega, I; Blanco-Arévalo, J L; Bosch-Mestres, J; González-Cordón, A; Estrach-Panella, T; García-de Olalla, P; Alsina-Gibert, M

    2016-04-01

    The number of consultations for sexually transmitted infections (STIs) is increasing in Spain. The aim of this study was to describe and analyze the epidemiological, behavioral, clinical, and microbiological characteristics of patients registered at the STI unit of a tertiary hospital. This was a retrospective, single-center descriptive study carried out between 2010 and 2013 in a multidisciplinary unit specialized in STIs, situated in a tertiary hospital. Epidemiological, clinical, and behavioral data were gathered using a face-to-face interview and a standardized questionnaire. Samples were collected for microbiology analysis. The study included 546 patients: 96% were men, 41% had human immunodeficiency virus (HIV) infection, and 56% were men who have sex with men. The reasons for consultation were the following: urethritis; genital, anal, or perianal ulcers; proctitis; oral ulcers; sexual contact with a person with a known STI; and high-risk sexual contact. The most common microbiological diagnoses were Neisseria gonorrhoeae in urethritis, Treponema pallidum in genital and anal or perianal ulcers, and Chlamydia trachomatis lymphogranuloma venereum serovars in proctitis. The highest prevalences of the main STIs studied occurred in homosexual men with HIV infection. This study confirms the increase in the incidence of STIs in recent years and the epidemiological characteristics of the HIV/STI epidemic in Spain. Copyright © 2015 AEDV. Published by Elsevier España, S.L.U. All rights reserved.

  8. Los años olvidados de Bibendum. La etapa americana de Michelin en Milltown. Diseño, ilustración y publicidad en las compañías del neumático (1900-1930)

    OpenAIRE

    Medrano Bigas, Pablo

    2015-01-01

    [spa] Durante la primera década de 1900, la empresa francesa del sector del neumático MICHELIN, con fábrica en Clemont-Ferrand y oficinas comerciales en París, desplegó un proceso de internacionalización. Se crearon filiales en los centros neurálgicos de los principales mercados: en Gran Bretaña (con sede y almacenes en Londres desde 1905), en Italia (con fábrica en Turín activa desde 1907) y, finalmente, en los Estados Unidos de América (En Milltown, New Jersey, con fábrica activa desde 190...

  9. EL EMPRESARIADO COMO FUENTE DE LA SEGREGACION POR SEXO

    Directory of Open Access Journals (Sweden)

    de Luis Carnicer, P.

    2009-01-01

    Full Text Available Este artículo presenta una parte de una amplia investigación cuyo objetivo era proponer Políticas Activas Institucionales para favorecer la inserción laboral de las mujeres en sectores o profesiones en las que estén subrepresentadas. El trabajo trata de profundizar en el comportamiento del empresariado para determinar cual es su grado de responsabilidad e influencia en la segregación sexual del mercado de trabajo. Para ello se realizó un estudio cualitativo. Los resultados nos muestran un aumento de la sensibilización. Los empresarios creen que no es justo, pero no se sienten responsables. Demandan una mayor participación del Gobierno y de la sociedad en general, a la vez que reconocen desconocer las políticas activas institucionales existentes.

  10. Factores psicosociales asociados con la resiliencia en niños colombianos víctimas de violencia intrafamiliar

    Directory of Open Access Journals (Sweden)

    José Juan Amar Amar

    2003-01-01

    Full Text Available El artículo refleja los hallazgos de la investigación realizada para conocer los factores psicosociales mediante los cuales los niños víctimas de la violencia intrafamiliar activa y/o pasiva pueden desarrollar una personalidad resiliente. La muestra estuvo conformada por 31 sujetos resilientes de los cuales 14 reportaron violencia intrafamiliar activa y 17 violencia intrafamiliar pasiva, en edades comprendidas entre los 7 y 12 años. Mediante el uso de una entrevista semi - estructurada inicial y una entrevista abier-ta personal se llevó a cabo la recolección de los datos. Los resultados coinciden, al igual que la base teórica revisada, en que los niños resilientes de la muestra presentan características y factores que los protegen de la adversidad y les permiten un desarrollo psicosocial positivo.

  11. MAJOR TRENDS IN THE DEVELOPMENT OF ANKLE REHABILITATION DEVICES

    Directory of Open Access Journals (Sweden)

    WILBERTH ALCOCER

    2012-01-01

    Full Text Available En este artículo se aborda el tema relacionado con la evolución de la robótica industrial orientada a tareas de rehabilitación. La importancia de las lesiones de tobillo y su adecuado procedimiento de rehabilitación pasiva o activa, es también considerada. Se han revisado los dispositivos de rehabilitación del tobillo, tanto los que ya están comercialmente disponibles como aquellos en etapa de desarrollo en laboratorios y centros de investigación. Al final de este artículo se propone la posibilidad de desarrollar un dispositivo mecatrónico, de complejidad intermedia, para rehabilitación del tobillo, orientado a la rehabilitación activa y con algunas características particulares.

  12. Tratamiento médico de la úlcera péptica

    Directory of Open Access Journals (Sweden)

    Alberto Albornoz Plata

    1958-09-01

    Full Text Available El tratamiento médico de la ulcera péptica, se basa esencialmente en aliviar los síntomas, lograr su cicatrización, evitar las complicaciones y procurar que las recurrencias sean mínimas o tolerables; además en la actualidad tiene una gran importancia el aspecto preventivo: un paciente con antecedentes ulcerosos o con herencia ulcerosa, debe quedar instruido por su médico, sobre la naturaleza de la enfermedad y sobre aquellas medidas de orden preventivo que debe observar toda la vida para evitar la enfermedad; cobra especial interés, en estos momentos en que infinidad de drogas que podemos llamar GASTROTOXICAS son de uso frecuente en medicina general y para muchas enfermedades que ahora tienen una alta incidencia, el uso de cortisona y derivados en enfermedades del colágeno, artritis, alergias, etc.; tranquilizadores e hipotensores a base de Rauwolfia; analgésicos de tan amplio uso como la aspirina, etc., etc.

  13. Diagnóstico histológico de la infección por Helicobacter pylori en Pinar del Río, Cuba

    Directory of Open Access Journals (Sweden)

    Zulema Ledesma

    2010-04-01

    Full Text Available El objetivo de este estudio fue relacionar la infección por Helicobacter pylori con los diagnósticos histológicos encontrados en 213 pacientes. Se comprobó la presencia de la bacteria mediante coloración con fucsina. De acuerdo con el diagnóstico endoscópico se obtuvieron los resultados siguientes: úlcera gástrica maligna 7 (3,65%, cáncer gástrico 7 (3,65%, dispepsia no ulcerosa, incluyendo gastritis crónica, 172 (89,58%. Del total de 213 biopsias gástricas obtenidas, 192 (90,14 % fueron positivas al diagnóstico histológico de H. pylori. El estudio permitió el reconocimiento de las alteraciones hísticas de la mucosa gástrica en la infección por esta bacteria. El cáncer gástrico (adenocarcinoma en su mayoría se asoció con la presencia de H. pylori. Se confirma la urgente necesidad de continuar estos estudios con diseños poblacionales, así como en el futuro buscar soluciones al problema con terapias más efectivas y con vacunas

  14. Pie varus equino congénito (Factores etiológicos

    Directory of Open Access Journals (Sweden)

    Valentín Malagón-Castro

    1955-04-01

    Full Text Available La causa eficiente del pié varus equino congénito, es en la actualidad desconocida. Existen, sin embargo, múltiples teorías orientadas a la explicación de este problema : Teorías atávica y arquiterígea, de Bardeleben, 1878 y Gegenbauer, 1864. Teoría de la Falla circulatoria de Keith, 1940, y de la Displasia fetal de Streeter, 1930; Teoría de la "Flictena" de Bagg, 1920 y Bonnevie, 1934. La Miodistrofia de Middleton, 1934; La presión mecánica intrauterina de Hipócrates, Dermis Browne, etc. La acción de las bridas amniótica y de la Enfermedad ulcerosa del amnios. Ombredanne. La detención en el desarrollo embrionario. Bohm. Los factores genéticos y las causas adyuvantes que pueden obrar sobre éstos: Deficiencia de la dieta materna durante el embarazo; irradiaciones, traumas, enfermedades y drogas recibidas durante la gestación, etc.

  15. Studies on the usefulness of negative contrast medium for CT-fatty emulsion-in diseases of the gastrointestinal tract

    Energy Technology Data Exchange (ETDEWEB)

    Uchida, Tsuneo; Kameda, Kyoko; Tanaka, Koji; Nishimura, Shigeru; Higashide, Toshiaki [Osaka Police Hospital (Japan)

    1983-09-01

    Investigation was made on the usefulness of negative contrast medium for CT-fatty emulsion-, which is applicable to the whole area of the gastrointestinal tract, in diagnoses of diseases of the stomach, pancreas, colon and the organs adjacent to the three. After the administration of the drug, CT was performed and the thickness of the walls were measured for the normal upper gastrointestinal tract in 50 patients and for the normal colon in 25. The normal gastric walls did not exceed 5 mm and the walls of the colon measured about 2.1 mm. Gastric tumors were projected at 80.4%. Especially, the drug was useful for the early diagnosis of schirrus. The pancreas was more clearly projected in 88.4% of the patients. The reconstruction method using the present drug was useful for the investigation of the relationship between the two organs, the stomach and the duodenum, and the pancreas. When CT was performed on a patient laying this right side on the bed, invasion of pancreatic cancer and gastric antrum cancer into the circumferntial organs could be diagnosed. The drug was useful for the identification of tumors in the colon and intrapelvic lesions. The medium was also given to four patients with colitis ulcerosa and the obtained findings on the wall features were same as those obtained by barium enema. The present drug was little associated with side effects and is considered to be an excellent negative contrast medium for all the gastrointestinal tracts.

  16. Consenso mexicano sobre probióticos en gastroenterología

    Directory of Open Access Journals (Sweden)

    M.A. Valdovinos

    2017-04-01

    Resultados y conclusiones: Se generaron 11 enunciados sobre conceptos generales de probióticos y 27 enunciados sobre uso de probióticos en enfermedades gastrointestinales tanto en niños como en adultos. El grupo de consenso recomienda el uso de probióticos en las siguientes condiciones clínicas: prevención de la diarrea asociada a antibióticos, tratamiento de la diarrea aguda infecciosa, prevención de infección por Clostridium difficile y enterocolitis necrosante, para disminuir los eventos adversos de la terapia de erradicación del Helicobacter pylori, el alivio de los síntomas del síndrome de intestino irritable, en el estreñimiento funcional del adulto, para inducir y mantener la remisión en pacientes con colitis ulcerosa crónica idiopática y pouchitis, y en la encefalopatía hepática oculta y manifiesta.

  17. Complications encountered in contrast roentgenography of the colon

    International Nuclear Information System (INIS)

    Vogel, H.; Steinkamp, U.

    1983-01-01

    The following problems are analysed referring to the literature and to practical experience of the authors: - Types of complications encountered in contrast roentgenography or in endoscopy of the colon, and their frequency. - Risk factors and secondary injuries. Intestinal perforation is the most frequent complication experienced as a consequence of contrast barium enema. The main risk factors are to be seen in the use of balloon-tipped catheters, or of intestinal tubes with hard tips, in a rise of hydrostatic pressure above 80 cm water column, and in an excessively strong air insufflation. Frequency of complications for contrast barium enema is stated to be 0.002 p.c. (Welin and Welin, 1980) or 0.08 p.c. (Clark et al. 1961). The frequency of perforations in rectoscopy is shown to be in the same order of magnitude. For diagnostic colonoscopy, the frequency of complications is about one per mil. Existing diseases such as carcinoma, diverticulosis, diverticulitis, colitis ulcerosa, or morbus Crohn are factors enhancing the risk. Also, patients of advanced age are running a higher risk due to decreasing intestine wall elasticity with age. Previous biopsy or excision forbids contrast barium enema for the next two weeks. Injuries and sequelae to be expected after perforation are abscesses, phlegmon, peritonitis including formation of adhesion and bands, retroperitoneal fibrosis with formation of hydronephrosis, and anus praeter, the latter being temporary or permanent. An extensive literature survey covering 200 publications has been prepared and is available from the authors upon request. (orig.) [de

  18. La etimología del cáncer y su curioso curso histórico Cancer etymology and its historical curious course

    Directory of Open Access Journals (Sweden)

    Oswaldo Salaverry

    2013-03-01

    Full Text Available Se discuten las primeras descripciones de cáncer en la historia de acuerdo a recientes hallazgos y sus interpretaciones que lo muestra como un grupo de enfermedades raras hasta el siglo XVIII, cuando comenzó su incremento hasta los niveles actuales. La literatura médica muestra numerosos antecedentes de supuestas lesiones cancerosas que, en realidad, corresponden a otras lesiones. Parte de la explicación se refiere a un malentendido etimológico acerca de la palabra griega karkinos que significaba cáncer, en su sentido moderno, pero también lesión ulcerosa. Se revisa ampliamente esta confusión en la antigua literatura médica y luego se esbozan los principales hitos de la concepción moderna del cáncer hasta el siglo dieciochoThe first cancer descriptions in history are discussed according to recent findings and their interpretation, which show it as a group of unknown diseases until the 18th century, when it started to increase to actual levels. Medical literature shows a variety of what were considered cancer lesions, which are actually different lesions. This is partly due to an etymological misunderstanding of the Greek term karkinos that, in its modern sense, meant “cancer”, but also ulcerative lesion. This confusion is widely reviewed in the ancient medical literature and the main landmarks of modern cancer conception up to the 18th century are outlined

  19. Alterações patológicas do apêndice vermiforme contendo Proglottis de Taenia sp

    Directory of Open Access Journals (Sweden)

    C. Magarinos Torres

    1943-06-01

    Full Text Available Pathological changes in the vermiform appendix harbouring tapeworm's proglottides are reported. Marked local (tissue eosinophilia in the stroma of the mucous coat and to a less degree in the sub-mucosa and around the vessels in the inner circular layer of the muscular coat is the essential change observed. Peculiar changes such as an striking increase in the volume of the mucus-producing goblet-cells either in the epithelium covering the free surface or in the glands of Lieberkühn, as well as new epithelium atypical in form and arrangement were noticed in direct connection and likely induced by the tapeworn as a foreign body (mechanical injury. The local (tissue eosinophilia probably represents an anaphylactoid response to foreign proteins originating in the tapeworm. Acute appendicitis in its recognized varieties such as appendicitis superficalis catarrhalis, a. s. exulcerans, a. s. haemorrhagica, a. phlegmonosa, and a. phlegmonosa-ulcerosa could be microscopically excluded. It seems, however, that local (tissue eosinophilia when particularly widespread is able to give clinical symtoms suggestive of acute appendicitis.

  20. Eritema multiforme mayor desencadenado por antimicrobianos

    Directory of Open Access Journals (Sweden)

    Ronaldo de Carvalho Raimundo

    2010-03-01

    Full Text Available El eritema multiforme, aparece como una enfermedad sistémica con la participación de la piel y las membranas mucosas en relación con varios factores como las infecciones bacterianas o virales, y en particular la administración de drogas, analgésicos y antibióticos en general. Se presenta un paciente masculino de 29 años de edad con eritema multiforme mayor desencadenado por antimicrobianos con la aparición de lesiones vesiculares-bulloso-ulcerosas en las regiones de los labios, encías, la lengua y la mucosa genital en tratamiento de una infección del tracto urinario con norfloxacino 400 mg por una semana. Fue realizado un tratamiento de soporte con el uso de colutorios para la higienización bucal y pomada a base de corticoide para protección de las úlceras, antihistamínicos y orientación nutricional de dieta líquida hipercalórica e hiperproteica. Este síndrome está caracterizado como un proceso eruptivo buloso agudo que compromete la calidad de vida del paciente y no hay pruebas de laboratorio específicas por lo que su diagnóstico debe estar basado en la revisión minuciosa de la anamnesis y en los hallazgos clínicos.

  1. Pulp-Capping with Mineral Trioxide Aggregate

    Directory of Open Access Journals (Sweden)

    Peycheva Kalina

    2015-11-01

    Full Text Available There are two considerations for direct pulp capping - accidental mechanical pulp exposure and exposure caused by caries. Mineral trioxide aggregate (MTA was used as pulp-capping material to preserve the vitality of the pulpal tissues. Follow-up examinations revealed that treatment was successful in preserving pulpal vitality and continued development of the tooth. On the basis of available information, it appears that MTA is the material of choice for some clinical applications. Material and methods: Cases 18 - 8 teeth with grey MTA, 10 teeth with white MTA; diagnose: Pulpitis chronica ulcerosa, Electro pulpal test (EOD - 30-35 μA, pre-clinical X-ray - without changes in the structures, follow ups for 4 years. Successful treatments: without clinical symptoms and changes in the X-rays: 5 teeth with grey MTA, 8 teeth with white MTA for period of 4 years. Unsuccessful treatments: Clinical symptoms and sometimes changes in the X-ray: 3 with grey MTA, 2 with white MTA. MTA is an appropriate material for pulp-capping and follow-up examinations revealed that the treatment was successful in preserving pulpal vitality.

  2. Lysophosphatidic Acid Regulation and Roles in Human Prostate Cancer

    Science.gov (United States)

    2006-08-01

    IGF-II ( insulin -like growth factor-II), and hormones have been implicated in the growth and survival of prostate cancer cells [1]. A recent addition to...sphingomyelin. In the synthesis of sphingomyelin, a phosphocholine group is transferred from phosphatidylcholine to ceramide. Sphin- gomyelin synthesis...cytotoxicity of TNF-α [78]. A phosphatidylcholine -specific phospholipase C activity was also required for aSMase activa- tion [79,80]. It is assumed that

  3. Regulatory Control of the Resolution of DNA Recombination Intermediates during Meiosis and Mitosis

    OpenAIRE

    Matos, Joao; Blanco, Miguel G.; Maslen, Sarah; Skehel, J. Mark; West, Stephen C.

    2011-01-01

    The efficient and timely resolution of DNA recombination intermediates is essential for bipolar chromosome segregation. Here, we show that the specialized chromosome segregation patterns of meiosis and mitosis, which require the coordination of recombination with cell-cycle progression, are achieved by regulating the timing of activation of two crossover-promoting endonucleases. In yeast meiosis, Mus81-Mms4 and Yen1 are controlled by phosphorylation events that lead to their sequential activa...

  4. Mercadeo social y desarrollo

    OpenAIRE

    Luis E. Eladio Proaño

    2015-01-01

    Afirma el autor que todos los proyectos de desarrollo fracasan porque no tienen en cuenta la cooperación de las organizaciones comunitarias. Lograr el apoyo de la población a través de su activa participación en los planes de desarrollo,la ejecución y control de los diferentes programas es uno de los propósitos del "nuevo mercadeo social".

  5. La asistencia a juicios y su simulación como nuevos métodos de aprendizaje del Derecho procesal

    OpenAIRE

    Bellido Penadés, Rafael

    2014-01-01

    El presente artículo tiene como fin analizar dos métodos de enseñanza en los que el alumno participa de forma activa: la asistencia a juicios y la simulación de procesos. Estas actividades producen buenos resultados en el aprendizaje del Derecho Procesal, según se desprende de diferentes encuestas en las que se evalúan algunas experiencias docentes

  6. Hacer atractivo el aprendizaje de la matemática, insertando los contenidos dentro de modelos reales

    OpenAIRE

    Arancibia, Sara

    2004-01-01

    Diversos estudios sobre tecnologías educativas para la docencia superior, formulan la participación activa y aprendizajes significativos, complementado con trabajo interactivo y autoestima positiva. Investigadores en educación afirman que “Construimos significados cuando relacionamos las nuevas informaciones con nuestros esquemas previos de comprensión de la realidad”. Por tanto, se propone incluir los contenidos dentro de situaciones naturales que impliquen el enfrentamiento del alumno con t...

  7. Anales del XIII Congreso Argentino de Ciencias de la Computación (CACIC)

    OpenAIRE

    Red de Universidades con Carreras en Informática (RedUNCI); Simari, Guillermo Ricardo; De Giusti, Armando Eduardo

    2007-01-01

    Contenido: Arquitecturas de computadoras Sistemas embebidos Arquitecturas orientadas a servicios (SOA) Redes de comunicaciones Redes heterogéneas Redes de Avanzada Redes inalámbricas Redes móviles Redes activas Administración y monitoreo de redes y servicios Calidad de Servicio (QoS, SLAs) Seguridad informática y autenticación, privacidad Infraestructura para firma digital y certificados digitales Análisis y detección de vulnerabilidades Sistemas o...

  8. Anormalidades metabólicas en pacientes con infección por VIH

    OpenAIRE

    Rodríguez Carranza, Sandra I.; Aguilar Salinas, Carlos A.

    2004-01-01

    La terapia antirretroviral altamente activa (TARAA) en pacientes con infección por virus de inmunodeficiencia humana (VIH) disminuyó la morbimortalidad del padecimiento, sin embargo, sus efectos sobre el metabolismo de lipoproteínas, carbohidratos y tejido adiposo son causa frecuente de consulta y en el futuro de morbimortalidad. Nuestro objetivo es describir el estado actual del conocimiento sobre la epidemiología, fisiopatología, diagnóstico y tratamiento de estas complicaciones. Se incluye...

  9. Situación de los desinfectantes de uso ambiental y en industria alimentaria registrados en España tras la publicación de la Directiva 98/8/CE

    Directory of Open Access Journals (Sweden)

    Ana Jiménez Zabala

    2011-01-01

    Full Text Available Fundamentos, La Directiva 98/8/CE armoniza y regula en el mercado europeo la autorización y registro de biocidas y establece un periodo de 14 años para la revisión de sustancias activas. Este trabajo analiza los cambios más relevantes producidos en el registro de biocidas desinfectantes registrados desde la publicación de la Directiva. Métodos, La información se ha obtenido del registro de Biocidas publicado en la web del Ministerio de Sanidad, Política Social e Igualdad a mayo de 2010. Se ha utilizado una hoja de cálculo Excel para el volcado y tratamiento de los datos. Resultados, Existen 1.575 biocidas desinfectantes (1137 formulados y 438 ingredientes activos técnicos registrados en España destinados a uso ambiental y en industria alimentaria. Los formulados están compuestos por 56 sustancias activas que están siendo estudiadas para su inclusión en la lista comunitaria de sustancias autorizadas. El 54% de los formula-dos están registrados como bactericida-fungicida, el 79% se aplican por contacto, el 42% son compuestos de amonio cuaternario y el 67.9% están elaborados con una sola sustancia activa. Respecto a su peligrosidad el 45.3% son corrosivos, el 25.7% irritantes, el 9.8% nocivos, el 1.1 % tóxicos y el 33.1% son peligrosos para el medio ambiente. Conclusiones: El registro de biocidas español se adecua a lo establecido en la Directiva cancelando los registros que contienen sustancias no incluidas en la lista. El 58% de las sustancias activas de uso ambiental y el 76,4% de uso en industria alimentaria en revisión en Europa se encuentran autorizadas en España.

  10. Comparación de cambios clínicos y hemodinámicos en pacientes con insuficiencia venosa mixta según tipo de manejo.

    OpenAIRE

    Escobar Diaz, Alejandro

    2015-01-01

    Existen varias causas de la insuficiencia venosa profunda, la insuficiencia venosa superficial es una de ellas; por tal motivo, una intervención activa de la insuficiencia superficial ya sea cirugía convencional, esclerosis o radiofrecuencia mejora el reflujo del sistema venoso profundo. En nuestro medio no se acostumbra a intervenir los pacientes con insuficiencia venosa mixta bajo la creencia de exacerbar la enfermedad o generar complicaciones. Se pretende documentar los cambios clínicos y ...

  11. Motivating Senior High School Students in English Learning

    Institute of Scientific and Technical Information of China (English)

    章小焕

    2015-01-01

    Motivation is the key to students’ English learning. To know how to promote students’ motivation in learning English, we need to know e-nough about motivation itself. In fact, motivation is so important to successful English learning that we must find the ways to promote students’ motivation. This paper focuses on identifying students’ problems of motivation and activa-ting their motivation to learn English with some useful ways.

  12. Seguimiento de las recomendaciones en prevención secundaria cerebrovascular en atención primaria

    Directory of Open Access Journals (Sweden)

    Carmen Tamayo-Ojeda

    2017-06-01

    Conclusiones: El seguimiento de las recomendaciones de las guías clínicas para la prevención de la enfermedad cerebrovascular en atención primaria es mejorable, especialmente en los más jóvenes. Son necesarios cambios organizativos e intervención más activa de los profesionales, así como estrategias para combatir la inercia terapéutica.

  13. Cervicoartrosis: efectividad de un tratamiento fisioterápico convencional

    OpenAIRE

    Pérez Navarro, Mario; García Madrid, José Luis; Pérez Albert, José María; Martínez Fuentes, Juan

    2005-01-01

    El objetivo de este estudio consiste en valorar la efectividad de un tratamiento de fisioterapia convencional para la cervicoartrosis (microondas, tracción cervical, movilización activa, masaje e higiene postural). Para su realización, se han seleccionado 32 pacientes (26 mujeres y 6 hombres) diagnosticados de cervicoartrosis. Se han valorado factores como el dolor y el balance articular. Tras analizar los resultados, concluimos que el tratamiento planteado es efectivo en la patol...

  14. Expectativas y experiencias de uso de las mujeres gitanas mayores ante los servicios sanitarios de atención primaria

    Directory of Open Access Journals (Sweden)

    Antonio Jesús Ramos-Morcillo

    2015-04-01

    Conclusiones: Las mujeres gitanas mayores plantean sus expectativas y experiencias en los servicios de AP alrededor del binomio enfermedad/médico. Esperan una atención basada en la confianza y con una alta instrumentalización. Se observa un discurso con signos de cambio dirigidos hacia una participación más activa y reivindicativa en los servicios de AP.

  15. Los Fondos Híbridos de Brasil: Performance, Persistencia y Gestión

    OpenAIRE

    Lima Crisóstomo, Vicente; Vallelado González, Eleuterio

    2006-01-01

    [ES] Este trabajo pretende estudiar los fondos “híbridos” (multicartera) en Brasil. Estos fondos requieren una gestión activa en un mercado financiero en desarrollo. Hemos analizado el desempeño, su persistencia, y los posibles factores determinantes de su rentabilidad. Los resultados indican que este tipo de fondos obtienen rentabilidades superiores a la del activo libre de riesgo, pero no mantienen sus resultados en periodos consecutivos a corto plazo. Existen importantes diferencias de per...

  16. LEYENDO P4L4BR4S y NÚM3R05

    Directory of Open Access Journals (Sweden)

    Manuel Carreiras

    2008-04-01

    Full Text Available Un aspecto clave en lectura es el proceso de reconocimiento de las letras en las palabras. Dicho proceso tiene un componente de normalización de la información sensorial conforme a unos patrones almacenados. Un ejemplo es que cuando leemos un ítem como M4T3R14L se activa inicialmente el significado de MATERIAL.

  17. Expresión de las moléculas del Complejo Mayor de Histocompatibilidad clase II y moléculas co-estimuladoras en carcinomas orales in vitro

    OpenAIRE

    Villarroel, Mariana; Speight, Paul M.; Barrett, A. William

    2005-01-01

    El descubrimiento de que el epitelio escamoso estratificado que cubre la mucosa oral podia expresar moleculas del Complejo Mayor de Histocompatibilidad clase II en varias condiciones patologicas de tipo inflamatorio abrio la posibilidad de que los queratinocitos orales sean celulas inmunologicamente activas, las cuales pueden funcionar con .celulas presentadoras de antigenos'ñ. Para una efectiva activacion de los linfocitos T, las celulas presentadoras de antigenos requie...

  18. Alteration of the carboxyl-terminal domain of Ada protein influences its inducibility, specificity, and strength as a transcriptional activator.

    OpenAIRE

    Shevell, D E; LeMotte, P K; Walker, G C

    1988-01-01

    The ada gene of Escherichia coli K-12 encodes the regulatory protein for the adaptive response to alkylating agents. A set of plasmids carrying ordered deletions from the 3' end of the ada gene were isolated and characterized. These ada deletions encode fusion proteins that derive their amino termini from ada and their carboxyl termini from the downstream vector sequence that occurs before an in-frame stop codon. Several of these ada deletions encode Ada derivatives that constitutively activa...

  19. El potencial de los activos culturales asociados con la actividad turística como factor de desarrollo local en el barrio Getsemaní, Cartagena de Indias.

    Directory of Open Access Journals (Sweden)

    Alfonso Escobar Nieves

    2017-12-01

    Es importante resaltar el valor estratégico, los riesgos y las oportunidades asociados con la salvaguardia del patrimonio cultural y el desarrollo del turismo. Las comunidades deben liderar la gestión en el marco de la solidaridad y la cooperación para garantizar su supervivencia en un mundo globalizado, con participación activa de los distintos actores gubernamentales y privados del sector.

  20. Actividad física y autoconcepto, físico y general, a lo largo de la edad adulta

    Directory of Open Access Journals (Sweden)

    Guillermo Infante

    2011-01-01

    Full Text Available Este estudio tiene por objetivo precisar las diferencias, asociadas con tres momentos de la edad adulta, en el autoconcepto y en las autopercepciones físicas así como la relación de dichas diferencias con el sexo y la actividad física. Participaron en el estudio 912 personas (350 hombres; 560 mujeres de entre 23 y 64 años (M = 45.41; DE = 13.41 divididas en tres tramos de edad (23 a 34; 35 a 49; 50 a 64 años. Los participantes se autoclasificaron como personas activas o no activas. Para la medición del autoconcepto se utilizó el Cuestionario de Autoconcepto Físico (CAF compuesto por las siguientes escalas: habilidad física, condición física, atractivo físico, fuerza física, autoconcepto físico general así como autoconcepto general. Los resultados ponen de manifiesto que: a. varias de las dimensiones del autoconcepto disminuyen a medida que aumenta la edad de cada uno de los tres grupos estudiados; b. el descenso es menor en la mujeres que en los hombres; c. la percepción subjetiva de ser una persona activa se asocia positivamente con el autoconcepto físico; d. el descenso de autoconcepto asociado con la edad afecta en menor medida a las personas activas. Estos datos aportan nueva información a la investigación y pautas para la educación personal y física de las personas adultas.

  1. Ibi et cor tuum: The Twin Perils of Studium and Otium in English Renaissance Intellectual Culture

    OpenAIRE

    Obi, Gertrude

    2016-01-01

    My dissertation, “Ibi et cor tuum: The Twin Perils of Studium and Otium in English Renaissance Intellectual Culture,” investigates the ways in which the temptations posed by intellectual labor were conceptualized and navigated by English Renaissance humanists. The competition pitting the vita activa against the vita contemplativa, which every age—including ours—must resolve anew, generated a spate of writings engaging with the mixed legacy of classical and medieval Christian attitudes towards...

  2. The cellular cancer resistance of the SR/CR mouse

    DEFF Research Database (Denmark)

    Koch, Janne; Hau, Jann; Jensen, Henrik Elvang

    2012-01-01

    The SR/CR mouse phenotype, first described in 1999 in BALB/c and later bred into C57BL/6 mice, is resistant to cancer formation following high doses of cancer cells administered intraperitoneally. The tumor cell targeting and destruction mechanisms have not been identified. By fluorescence-activa...... controls. Importantly, this differentially regulated immune response of SR/CR mice could not be found in response to challenge with the lymphoma cell line EL-4....

  3. Use of Proktis-M suppositories in patients undergoing neoadjuvant radiochemotherapy for adenocarcinoma of the rectum.

    Science.gov (United States)

    Montrone, S; Gonnelli, A; Cantarella, M; Sainato, A

    2015-12-01

    Generally speaking, the negative side of radiation treatment of the pelvic district is the toxicity that may compromise the patient's quality of life and lead to temporary suspension of treatment with possible negative effects on its effectiveness. In neoadjuvant radiochemotherapy for locally advanced rectal cancer (LARC), the toxicity that is most frequently observed is proctitis, usually treated with topical corticosteroids or mesalazine. Hyaluronic acid's function is to restore the regular trophism and elasticity of the connective tissues leading to faster repair of the damage, and this could represent a viable option for the control of actinic proctitis. Since March 2012, a neoadjuvant radiochemotherapy protocol has been active at the Pisa Universitary Hospital for patients with LARC; 23 patients have been enrolled up to the present. Treatment involves an induction chemotherapy phase according to the FOLFOXIRI + Bevacizumab regimen for 6 cycles, followed by chemotherapy (capecitabina + Bevacizumab) concomitant with radiotherapy (5040 cGy in 28 fractions). Surgery is scheduled 6-8 weeks after the end of RTCT. During the course of associated treatment (RTCT), 12/23 patients received topical therapy with hyaluronic acid (Proktis-M suppositories) for the prevention of proctitis. All 23 patients enrolled in the study completed the induction chemotherapy phase. In the first 11 enrolled patients who did not receive prior Proktis-M suppositories, intense rectal toxicity was observed. Proctalgia of grade G1-2 and G3-4 presented respectively in 64% and 36% of cases, with consequent interruption of treatment which, in 45% of patients, lasted longer than 10 days. In the remaining 12 patients who underwent prior treatment with Proktis-M suppositories, the percentage of rectal toxicity was lower. In those cases where it did present, onset was later and its intensity and duration lower. 25% of patients did not develop proctalgia, 33% developed proctalgia of grade G1 and 42

  4. Radiation protection with mesalamine (5-amino salicylic acid)

    International Nuclear Information System (INIS)

    Onoda, James M.; Court, Wayne S.; Feldmeier, John J.; Alecu, Rodica

    1996-01-01

    Purpose: Radiation proctitis induced during the therapy of rectal and prostate cancers, and radiation injuries in general, are often the principal dose limiting factor limiting dose escalation for radiation therapy. Thus, there has been a continuous search for radioprotective agents, especially those that could selectively protect normal tissues, as opposed to the target cancer. 5-amino salicylic acid (5ASA) is in clinical use as Mesalamine for the local treatment of ulcerative proctitis. Inasmuch as other investigators have identified 5ASA as a free radical scavenger, we determined whether pretreatment with 5ASA could confer radiation protection. Materials and Methods: Adult male C57BL/6J mice obtained from Jackson Laboratories were employed for these studies. We determined LD50 for acute gastrointestinal death for young (≤ 10 weeks old, ≤ 25 gms body weight) and aged (≥ 1 year old, ≥ 35 gms body weight) animals exposed to single fractions (1 - 20 Gy) from three different radiation sources, Cs 137 , 270 KeV x-rays, and a 4 MeV linear accelerator. Experimental mice were pre- or post-treated with 5ASA in an acidified isotonic saline solution by oral, rectal, or intraperitoneal administration. Animals were housed, maintained by AAALAC standards and treated with antibiotics or acidified water post radiation exposure to control opportunistic infections. Animals were scored for death when moribund. Results: 5ASA was found to be radioprotective by oral, rectal or intraperitoneal administration when given 15 to 90 minutes prior to radiation exposure. Administration of drug following radiation exposure failed to confer radioprotection. We determined a dose effect for 5ASA with maximum tolerated dose of 200 mg/kg administered ip 30 minutes prior to 11 Gy whole body exposure. Dose modification and radioprotection by 5ASA were determined by LD50(6), LD50(30), or LD50(365). More recently, we determined that 5ASA conferred significant radioprotection to mice exposed to

  5. Association of rectal toxicity with thermal dose parameters in treatment of locally advanced prostate cancer with radiation and hyperthermia

    International Nuclear Information System (INIS)

    Hurwitz, Mark D.; Kaplan, Irving D.; Hansen, Jorgen L.; Prokopios-Davos, Savina; Topulos, George P.; Wishnow, Kenneth; Manola, Judith; Bornstein, Bruce A.; Hynynen, Kullervo

    2002-01-01

    Purpose: Although hyperthermia has been used for more than two decades in the treatment of pelvic tumors, little is known about the potential impact of heat on rectal toxicity when combined with other treatment modalities. Because rectal toxicity is a concern with radiation and may be exacerbated by hyperthermia, definition of the association of thermal dose parameters with rectal toxicity is important. In this report, we correlate rectal toxicity with thermal dose parameters for patients treated with hyperthermia and radiation for prostate cancer. Methods and Materials: Thirty patients with T2b-T3b disease (1992 American Joint Committee On Cancer criteria) enrolled in a Phase II study of external beam radiation ± androgen-suppressive therapy with two transrectal ultrasound hyperthermia treatments were assessed for rectal toxicity. Prostatic and anterior rectal wall temperatures were monitored for all treatments. Rectal wall temperatures were limited to 40 deg. C in 19 patients, 41 deg. C in 3 patients, and 42 deg. C in 8 patients. Logistic regression was used to estimate the log hazard of developing National Cancer Institute Common Toxicity Criteria Grade 2 toxicity based on temperature parameters. The following were calculated: hazard ratios, 95% confidence intervals, p values for statistical significance of each parameter, and proportion of variability explained for each parameter. Results: Gastrointestinal toxicity was limited to Grade 2. The rate of acute Grade 2 proctitis was greater for patients with an allowable rectal wall temperature of >40 deg. C. In this group, 7 of 11 patients experienced acute Grade 2 proctitis, as opposed to 3 of 19 patients in the group with rectal wall temperatures limited to 40 deg. C (p=0.004). Preliminary assessment of long-term toxicity revealed no differences in toxicity. Hazard ratios for acute Grade 2 proctitis for allowable rectal wall temperature, average rectal wall Tmax, and average prostate Tmax were 9.33 (p=0.01), 3

  6. Prevention of acute radiation-induced proctosigmoiditis by balsalazide: A randomized, double-blind, placebo controlled trial in prostate cancer patients

    International Nuclear Information System (INIS)

    Jahraus, Christopher D.; Bettenhausen, Doug Phar; Malik, Uzma M.B.B.S.; Sellitti, Marguerite; St Clair, William H.

    2005-01-01

    Purpose: A common complication of pelvic radiotherapy (RT) is acute radiation-induced proctosigmoiditis (RIPS), for which a multitude of therapies have been tried. The 5-aminosalicylates (5-ASA), which are traditionally used to treat inflammatory bowel disease, have been tested; however, all but one prior randomized attempt to limit or prevent RIPS with 5-ASA-type agents have failed. We sought to evaluate balsalazide, a new 5-ASA drug, for its potential to prevent or limit RIPS in patients undergoing RT for carcinoma of the prostate, as a representative sample of pelvic RT patients. Balsalazide has a unique delivery system in that 99% of ingested drug is delivered to and activated in the colon, a higher yield than all other oral agents currently available in this class. Furthermore, it lacks the antigenic sulfa moiety present in sulfasalazine, the only other 5-ASA with demonstrated benefit in this setting. Thus, it was deemed an ideal candidate for preventing or limiting RIPS. Methods and Materials: Eligible patients included prostate cancer patients, American Joint Committee on Cancer Stage T1-3, M0 being treated with external beam radiotherapy in University of Kentucky Department of Radiation Medicine. Between January 1, 2003 and July 1, 2004, 27 eligible patients were enrolled in the study. Patients were administered 2250 mg of balsalazide or an identical-appearing placebo twice daily beginning 5 days before RT and continuing for 2 weeks after completion. Toxicities were graded weekly according to National Cancer Institute Common Toxicity Criteria v. 2.0 for each of the following: proctitis, diarrhea, dysuria, weight loss, fatigue, nausea, and vomiting. A symptom index was formulated for each toxicity consisting of the toxicity's numeric grade multiplied by the number of days it was experienced, and summed for each grade experienced throughout the course of RT. Results: With the exception of nausea or vomiting, seen in 3 patients on balsalazide and 2 on placebo

  7. Influence of external beam technique and brachytherapy quality assurance on the side effects in the combined external beam- and brachytherapy treatment of local advanced prostate cancer

    International Nuclear Information System (INIS)

    Kovacs, G.; Galalae, R.; Wirth, B.; Bertermann, H.; Wilhelm, R.; Kohr, P.; Kimmig, B.

    1996-01-01

    Transrectal ultrasound(TRUS) guided HDR implantation of the prostate has been established at the Kiel University by Bertermann and Brix in 1986 and there are to date 179 (T1b-T3 No Mo) patients treated in a combined modality. The dose for the implant was 2x 15 Gy on the capsule of the prostate in 14-20 days. For local and regional lymph nodes 20 Gy external beam therapy (AP-PA pelvic portals), 20 Gy with an individual transmission block (100% for subclinical disease, 70% and 50% according to the implant dosimetry for the prostate) and 10 Gy small volume irradiation for the prostate was applied, conventional fractioned. Total dose after the therapy 70 Gy for the prostate and 50 Gy for the subclinical disease in 6-7 weeks. As a quality control method we use since 1991 in vivo dosimetry on the medial rectum wall as well as in the prostatic part of the urethra. Regular follow-up 3-118 months after therapy (median 55) with PSA, digital rectal examination, control TRUS with volumetry (after one year with biopsy) and bone scan. There were no major early side effects within the first three months. Proctitis till 1991 with a duration up to 12 months 49%, prolonging more than one year in 23 %, (total proctitis 72.6%). Dysuria in up to 12 months 30 %, long lasting 30% (total number of dysuria 60 %). Erectile dysfunction in 56 %. Because of the number of the side effects 1991 we changed the external beam technique: instead of the biaxial arch therapy the AP-PA portals, and reduced irradiated volume (from 6480 cm 3 to 5040 cm 3 ). We introduced instead of the small volume arch therapy for 10 Gy external boost the box-technique with shielding the back part of the rectum and the upper part of the bladder resulting additional volume reduction. Through the 15 Gy HDR brachytherapy dose on the prostate capsule there are up to 8 Gy on the medial rectal wall, measured by in vivo dosimetry. This dose could not be responsible for the high number of side effects (see gynecological

  8. INFLUENCIA DE LAS CONDICIONES DE INCUBACIÓN SOBRE LA ACTIVACIÓN DE ZOOSPORAS DE Spongospora subterranea, EN BUSCA DE UN INÓCULO PARA EL ESTUDIO DE LA SARNA POLVOSA INFLUENCE OF INCUBATION CONDITIONS ON THE ACTIVATION OF ZOOSPORES OF Spongospora subterranea, SEARCHING FOR AN INOCULUM TO THE STUDY OF THE POWDERY SCAB

    Directory of Open Access Journals (Sweden)

    Edgar Beltrán Sánchez

    2009-12-01

    Full Text Available La sarna polvosa es una enfermedad que decrece la producción de papa. Es causada por el parásito obligado Spongospora subterranea f. sp. subterranea, el cual produce grupos de zoosporas enquistadas llamados quistosoros. Cuando las zoosporas están activas pueden infectar raíces y tubérculos iniciando un nuevo ciclo reproductivo. Para estudiar la influencia de las condiciones de incubación sobre la activación de las zoosporas, suspensiones acuosas de quistosoros fueron incubadas bajo diferentes condiciones. Los quistosoros y las zoosporas activas fueron diariamente contados utilizando microscopio óptico. El mayor número de zoosporas activas se encontró al cuarto día de incubación, mientras que el menor número de quistosoros se registró al quinto día de incubación. Esto sugiere que las zoosporas permanecen activas por un corto periodo. El número de zoosporas activas por quistosoro fue significativamente (PThe powdery scab is a disease that decreases potato production. It is caused by Spongospora subterranea f. sp. subterranea. This obligate parasite produces cystosori, which are groups of encysted zoospores. When these zoospores are active, they can infect roots and tubers initiating a new replication cycle. To investigate the influence of the incubation conditions on the zoospore activation, suspensions of cystosori in water were incubated under different conditions. The cystosori and the active zoospores were daily counted under microscope. The higher number of active zoospores was found after four days of incubation, meanwhile the lower number of cystosori was found after five days of incubation. This suggests that zoospores are active for a short period. The number of active zoospores per cystosorus was significantly (P<0.05 higher in tap water than in distillated water, and in presence of light than in dark. More zoospores per cystosorus were activated at 19 °C than at 5 °C, but potato roots did not have a significant (P<0

  9. Fistulizing Crohn's disease: Diagnosis and management.

    Science.gov (United States)

    Gecse, Krisztina; Khanna, Reena; Stoker, Jaap; Jenkins, John T; Gabe, Simon; Hahnloser, Dieter; D'Haens, Geert

    2013-06-01

    Fistulizing Crohn's disease represents an evolving, yet unresolved, issue for multidisciplinary management. Perianal fistulas are the most frequent findings in fistulizing Crohn's disease. While enterocutaneous fistulas are rare, they are associated with considerable morbidity and mortality. Detailed evaluation of the fistula tract by advanced imaging techniques is required to determine the most suitable management options. The fundamentals of perianal fistula management are to evaluate the complexity of the fistula tract, and exclude proctitis and associated abscess. The main goals of the treatment are abscess drainage, which is mandatory, before initiating immunosuppressive medical therapy, resolution of fistula discharge, preservation of continence and, in the long term, avoidance of proctectomy with permanent stoma. The management of enterocutaneous fistulas comprises of sepsis control, skin care, nutritional optimization and, if needed, delayed surgery.

  10. Surgical treatment of radiation injuries of the colon and rectum

    International Nuclear Information System (INIS)

    Jao, S.W.; Beart, R.W. Jr.; Gunderson, L.L.

    1986-01-01

    Between 1950 and 1983, radiation-induced proctitis was diagnosed proctoscopically in 720 patients at the Mayo Clinic. Sixty-two patients with severe colorectal symptoms were treated surgically. The interval from cessation of radiotherapy to onset of symptoms ranged from 3 weeks to 24 months (mean 33 months). The 62 patients underwent a total of 143 operations with 8 operative deaths (13 percent), and 40 patients (65 percent) had 61 complications. The morbidity rate was lower after colostomy alone (44 percent in 27 patients) than after more aggressive operations (80 percent in 35 patients). Transverse loop colostomy and descending colostomy were safer than sigmoid colostomy. The dissection adhesions, opening of tissue planes, and careless manipulation of intestine may result in necrosis and perforation of the intestine, bladder, or vaginal wall; these were the main causes of fecal and other internal fistulas in our study

  11. Clinical feature of disturbance in the lower gastrointestinal tract development after radiation to tumor in the pelvis and its countermeasure

    International Nuclear Information System (INIS)

    Ikeda, Sadahito; Sunagawa, Shigenobu; Matsumura, Shigejiro; Masaoka, Takao; Uegaki, Kazuo

    1975-01-01

    The clinical features and the countermeasure were examined on 40 disturbances in the lower gastrointestinal tract developed after radiotherapy of cancer of the uterus, the ovary and the penis. Two to nine months after the irradiation with 10,000 R of Telecobalt and about 5,000 mch of 60 Co, complications such as melena, stenosis and fistula formation were developed. Seventeen of the 40 patients complained of melena and were treated as outpatient. Of the rest 23 patients, 11 were radiation proctitis with a large amount of melena, 9 were recto-sigmoid stenosis, 2 were rectovaginal fistula and 1 was fecal fistula formation. These patients received internal therapy composed of transfusion, hemostatic agent, steroid, solcoseryl suppository, antiulcerative drug and vitamin. However, the prognosis of them, particularly of the patients who were exposed a large amount of radiation, was very poor and the death rate reached 9 to 43%. (Kanao, N.)

  12. Acute coronary syndrome associated with Churg-Strauss syndrome

    Directory of Open Access Journals (Sweden)

    Annette Doris Wagner

    2007-11-01

    Full Text Available Annette Doris Wagner1, Gerd Peter Meyer2, Markus Rihl3, Anke Rathmann2, Ulrike Wittkop1, Henning Zeidler4, Hermann Haller1, Joachim Lotz51Department Internal Medicine, Division of Nephrology; 2Division of Cardiology; 3Division of Rheumatology; 4Rheumatologikum Hannover; 5Department of Diagnostic Radiology; Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, GermanyAbstract: A 41-year old female patient was admitted with acute onset of dyspnea and chest pain. Previous history revealed asthma, chronic sinusitis and eosinophilic proctitis. Electrocardiogram showed anterior ST-segment elevations and inferior ST-segment depression. Immediate heart catheterization revealed a distally occluded left anterior descending coronary artery, the occlusion being reversible after nitroglycerine. Cardiac magnetic resonance imaging was consistent with perimyocarditis. Hypereosinophilia and IgE elevation were present and Churg-strauss syndrome was diagnosed.Keywords: Churg-Strauss syndrome (CSS, carditis, cardiac MRI

  13. Abdominoendorectal resection with peranal anastomosis in the treatment of radiation injuries of the rectum

    Energy Technology Data Exchange (ETDEWEB)

    Athanasiadis, S.; Girona, J.

    1982-01-01

    During the period 1974-1980 39 patients underwent operations at the Prosper Hospital in Recklinghausen for radiation injuries to the rectum or rectosigmoid. They comprised 22 patients with rectovaginal fistulas, 6 with ulcers, 3 suffering from severe hemorrhagic proctitis, 5 with rectal strictures, 1 with necrosis, and 2 with radiation ulcers and carcinoma. A sphincter-saving operative method of treating postirradiation damage of the rectum is presented. The technique involves the peranal anastomosis of healthy colon to the midanal canal using a sleeve anastomosis. Technical and functional results of resectional surgery for the rectal complications of radiation therapy are reported. Subjectively, total continence was present in 78%, only 1 patient was incontinent because of flatus and watery stools.

  14. The abdominoendorectal resection with peranal anastomosis in the treatment of radiation injuries of the rectum

    International Nuclear Information System (INIS)

    Athanasiadis, S.; Girona, J.

    1982-01-01

    During the period 1974-1980 39 patients underwent operations at the Prosper Hospital in Recklinghausen for radiation injuries to the rectum or rectosigmoid. They comprised 22 patients with rectovaginal fistulas, 6 with ulcers, 3 suffering from severe hemorrhagic proctitis, 5 with rectal strictures, 1 with necrosis, and 2 with radiation ulcers and carcinoma. A sphincter-saving operative method of treating postirradiation damage of the rectum is presented. The technique involves the peranal anastomosis of healthy colon to the midanal canal using a sleeve anastomosis. Technical and functional results of resectional surgery for the rectal complications of radiation therapy are reported. Subjectively, total continence was present in 78%, only 1 patient was incontinent because of flatus and watery stools. (orig.) [de

  15. Increase in sexually transmitted infections in a cohort of outpatient HIV-positive men who have sex with men in the Parisian region.

    Science.gov (United States)

    Farfour, E; Dimi, S; Majerholc, C; Fourn, E; Séné, T; Chaida, M B; Vasse, M; Zucman, D

    2017-11-01

    To describe the increased incidence of sexually transmitted infections (STIs) in a cohort of HIV-infected men who have sex with men (MSM), followed in a tertiary hospital of the Île-de-France region. We performed a monocentric, retrospective, and prospective study. We included symptomatic HIV-infected MSM patients who consulted for their annual consultation. One hundred and eighty patients were seen between 2008-2011 and 215 between 2012-2015. We observed an increased incidence of STIs between the two periods (14 and 29.3%, respectively). These STIs includes: syphilis, hepatitis C, urethritis, and proctitis due to Chlamydia trachomatis and Neisseria gonorrhea. A better management of symptomatic and asymptomatic STIs is needed for HIV-infected MSM patients. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  16. Orgotein in radiation treatment of bladder cancer

    International Nuclear Information System (INIS)

    Nielsen, O.S.; Overgaard, J.; Overgaard, M.; Steenholdt, S.; Jakobsen, A.; Sell, A.; Kommunehospitalet, Aarhus

    1987-01-01

    The possible protective effect of orgotein (a superoxide dismutase) an radiation cystitis and proctitis was studied in patients with carcinoma of the urinary bladder. A double-blind study in 60 patients was planned but due to unacceptable side effects only 30 patients were included. Radiation treatment was given with curative intent at a dose of 63 Gy in 30 fractions. Orgotein was injected 15 min after each daily radiation treatment at a dose of 4 or 8 mg. No effect of orgotein on tumour radiation response or on the acute radiation reactions in the bladder and rectum was detected. Marked subcutaneous infiltration and redness was seen at the local injection site in 5 patients. No general symptoms were observed. Intradermal tests and antibody titration tests showed that the local reactions were due to allergic reactions to the drug itself. The lack of radioprotective effect and the high frequency of unaccaptable side effects makes orgotein an unsuitable drug in climical radiation therapy. (orig.)

  17. Kaposi sarcoma and lymphadenopathy syndrome: limitations of abdominal CT in acquired immunodeficiency syndrome

    International Nuclear Information System (INIS)

    Moon, K.L. Jr.; Federle, M.P.; Abrams, D.I.; Volberding, P.; Lewis, B.J.

    1984-01-01

    Abdominal computed tomography (CT) was performed in 31 patients with Kaposi sarcoma (KS) related to acquired immunodeficiency syndrome (AIDS), three patients with classic KS, and 12 patients with the newly described lymphadenopathy syndrome (LNS). The frequency, distribution, and appearance of lymphadenopathy and splenomegaly were similar in the AIDS-related KS and LNS groups. Rectal and perirectal disease was identified in 86% of homosexual men studied; rectal KS could not be distinguished from proctitis on CT criteria alone. No CT abnormalities were seen in patients with classic KS. The CT demonstration of retroperitoneal, mesenteric, or pelvic adenopathy or of rectal or perirectal disease in patients with AIDS-related KS is not necessarily indicative of widespread involvement with the disease

  18. 2013 European guideline on the management of lymphogranuloma venereum.

    Science.gov (United States)

    de Vries, H J C; Zingoni, A; Kreuter, A; Moi, H; White, J A

    2015-01-01

    WHAT IS NEW IN THIS UPDATED GUIDELINE?: This is the update version of the 2010 European guideline on the management of lymphogranuloma venereum (LGV). New issues are: Based on clonal relatedness of prevalent LGV strains there is evidence that the LGV epidemic among men who have sex with men (MSM) in the Western world prevailed already in the United States in the 1980s and was introduced into Europe by the end of the last century. A new LGV variant causing severe proctitis was unveiled and designated L2c. The L2b LGV variant causing the vast majority of infections among MSM is now also found among a few heterosexual women. Apart from HIV and STI screening, Hepatitis C Virus (HCV) testing should be offered to all LGV patients. To exclude reinfections, STI screening during a follow-up visit 3 months after an LGV diagnosis should be offered. © 2014 European Academy of Dermatology and Venereology.

  19. Asymptomatic urethral lymphogranuloma venereum: a case report.

    Science.gov (United States)

    Charest, Louise; Fafard, Judith; Greenwald, Zoë R

    2018-07-01

    Since 2003, there has been a resurgence of lymphogranuloma venereum (LGV), a variant of Chlamydia trachomatis (CT), among men who have sex with men (MSM) in several urban areas of Europe and North America. LGV infection occurs most often at anal sites causing proctitis. Urethral and oropharyngeal infections are rare. In Quebec, LGV incidence has been increasing exponentially in recent years and the current guidelines support systematic LGV genotype testing among anorectal CT-positive samples only. This case report describes a patient with a urethral LGV infection, remarkable due to its prolonged asymptomatic development prior to the manifestation of an inguinal bubo. Physicians should be vigilant of potential cases of LGV and forward CT-positive samples occurring among individuals with LGV risk factors for genotype testing.

  20. Lymphogranuloma venereum genovar L2b concomitantly with syphilis and hepatitis C in a male patient in Poland – case report

    Science.gov (United States)

    Serwin, Agnieszka Beata; Koper, Marta; Unemo, Magnus

    2018-01-01

    We describe the first case of lymphogranuloma venereum (LGV) in Poland, with inguino-femoral lymphadenopathy, diagnosed and successfully treated according to the 2013 European LGV guideline. Chlamydia trachomatis genovar L2b, mainly responsible for the ongoing LGV epidemics among men who have sex with men (MSM) in Western European countries, was confirmed. The case also verified that co-infections with other sexually transmitted infections (syphilis and hepatitis C virus) are frequent in MSM LGV patients, as well as the very large difficulties with contact tracing for these patients. LGV needs to be considered in the diagnosis of inguinal lymph nodes inflammation or proctitis, especially in MSM. It is also crucial to have access to appropriate laboratory diagnostic methods in order to screen for and confirm all LGV cases by typing C. trachomatis genovars.

  1. Emergence of the lymphogranuloma venereum L2c genovariant, Hungary, 2012 to 2016.

    Science.gov (United States)

    Petrovay, Fruzsina; Balla, Eszter; Erdősi, Tímea

    2017-02-02

    In eastern Europe, few countries have so far reported laboratory-confirmed cases of lymphogranuloma venereum (LGV). Here we describe 22 LGV cases in men who have sex with men (MSM) detected in Hungary from November 2012 to July 2016. Sequence analyses show that 16 of these 22 cases were affected by the L2c genovariant, with from 2012 to 2014, one LGV L2c case detected per year, followed by seven cases in 2015 and six up to July 2016. Of the 16 total L2c LGV cases, 10 had severe haemorrhagic proctitis. These findings are concerning as cases with this new genovariant among MSM have not been frequently reported in Europe to date. More research is needed to assess the spread of the L2c genovariant and its potential association with virulence and severe clinical manifestation. This article is copyright of The Authors, 2017.

  2. [Lymphogranuloma venereum].

    Science.gov (United States)

    Vaňousová, Daniela; Zákoucká, Hana; Marvan, Jaroslav; Jilich, David; Vojáčková, Naděžda; Hercogová, Jana; Machala, Ladislav

    2012-01-01

    Lymphogranuloma venereum is a sexually transmitted disease caused by serovars L1-3 of Chlamydia trachomatis. This infection was originally endemic in tropics and transmitted predominantly by heterosexual contact but since the beginning of the century it spreads in industrialized countries mainly among men having sex with men causing them severe proctitis. In the Czech Republic the first case was diagnosed in 2011. Lymphogranuloma venereum can resemble other forms of anorectal disorders inclusive inflammatory bowel diseases and thus it must be included into differential diagnostic considerations. Definitive diagnosis is based on detection of specific serovars of Chlamydia trachomatis by polymerase chain reaction. In patients with lymphogranuloma venereum it is also necessary to exclude other sexually transmitted diseases, particularly syphilis, HIV and also hepatitis C. The therapy of choice is doxycycline administered for three weeks.

  3. Neoadjuvant chemotherapy in locally advanced cervical cancer: two randomised studies

    International Nuclear Information System (INIS)

    Kumar, L.; Grover, R.; Pokharel, Y.H.; Chander, S.; Kumar, S.; Singh, R.; Rath, G.K.; Kochupillai, V.

    1998-01-01

    The results of two studies looking at the place of neo-adjuvant chemotherapy in the treatment of locally advanced cervical cancer being treated with radiotherapy are presented. Between August 1990 and January 1992, 184 patients with squamous cell carcinoma of the cervix, FIGO stage II B IVA were randomised (study 1) to receive either two cycles of bleomycin, ifosfamide-mesna and cisplatin (BIP) chemotherapy (CT) followed by radiotherapy (RT). Three patients died of CT toxicity - two in study 1 and one in study 2. Cystitis, proctitis and local skin reaction after RT occurred equally in the two groups in both the studies. The neo-adjuvant chemotherapy prior to radiotherapy demonstrated a high response rate, but this did not translate into improved overall survival compared to those patients receiving radiotherapy alone

  4. Emerging role of thalidomide in the treatment of gastrointestinal bleeding.

    Science.gov (United States)

    McFarlane, Michael; O'Flynn, Lauren; Ventre, Rachel; Disney, Benjamin R

    2018-04-01

    Thalidomide was initially synthesised in 1954 and marketed as a sedative and antiemetic for morning sickness. It was withdrawn in 1961 due to the realisation that it was teratogenic with over 10 000 children born with congenital abnormalities. Since then it has been used for treatment of dermatological and oncological conditions, including myeloma. In 1994, it was found to have a potent antiangiogenic effect via downregulation of vascular endothelial growth factor (VEGF). This has led to its use in gastrointestinal bleeding, as vascular abnormalities such as angiodysplasia have been found to have elevated VEGF levels. This article will review the current evidence of the use of thalidomide in bleeding associated with gastrointestinal vascular malformations, including angiodysplasia, gastric cancer and radiation-induced proctitis.

  5. Histological changes in rectum following radiotherapy in cases of carcinoma cervix uteri

    Energy Technology Data Exchange (ETDEWEB)

    Gill, J K; Rohatgi, V K; Lahiri, B; Aggarwal, B M [S.N. Medical Coll., Agra (India)

    1978-05-01

    Rectal biopsy was done in 39 follow-up cases of squamous cell carcinoma of cervix treated with radiotherapy who clinically presented as cases of radiation proctitis. On histological examination, definite evidence of radiation injury was found in 23 cases. In rectal mucosa, radiation ulcers, broken epithelial lining, glandular atrophy, inflammatory cell infiltration, and edema of stroma were seen. Muscularis mucosa was either intact or partially broken. In submucosa, blood vessels showed endarteritis, plasma cell infiltration, fibrinoid necrosis, and hyalinization of vessel wall. In a few cases, hyalinization, edema, and vacuolation of muscle fibres were seen in muscle layer. In one case, squamous cell carcinoma of rectum was diagnosed. During follow-up examinations no complication due to rectal biopsy was observed.

  6. Argon Plasma Coagulation Therapy Versus Topical Formalin for Intractable Rectal Bleeding and Anorectal Dysfunction After Radiation Therapy for Prostate Carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Yeoh, Eric, E-mail: eric.yeoh@health.sa.gov.au [Department of Radiation Oncology, Royal Adelaide Hospital, Adelaide (Australia); School of Medicine, University of Adelaide, Adelaide (Australia); Tam, William; Schoeman, Mark [School of Medicine, University of Adelaide, Adelaide (Australia); Department of Gastroenterology, Royal Adelaide Hospital, Adelaide (Australia); Moore, James; Thomas, Michelle [School of Medicine, University of Adelaide, Adelaide (Australia); Department of Colorectal Surgery, Royal Adelaide Hospital, Adelaide (Australia); Botten, Rochelle; Di Matteo, Addolorata [Department of Radiation Oncology, Royal Adelaide Hospital, Adelaide (Australia)

    2013-12-01

    Purpose: To evaluate and compare the effect of argon plasma coagulation (APC) and topical formalin for intractable rectal bleeding and anorectal dysfunction associated with chronic radiation proctitis. Methods and Materials: Thirty men (median age, 72 years; range, 49-87 years) with intractable rectal bleeding (defined as ≥1× per week and/or requiring blood transfusions) after radiation therapy for prostate carcinoma were randomized to treatment with APC (n=17) or topical formalin (n=13). Each patient underwent evaluations of (1) anorectal symptoms (validated questionnaires, including modified Late Effects in Normal Tissues–Subjective, Objective, Management, and Analytic and visual analogue scales for rectal bleeding); (2) anorectal motor and sensory function (manometry and graded rectal balloon distension); and (3) anal sphincteric morphology (endoanal ultrasound) before and after the treatment endpoint (defined as reduction in rectal bleeding to 1× per month or better, reduction in visual analogue scales to ≤25 mm, and no longer needing blood transfusions). Results: The treatment endpoint was achieved in 94% of the APC group and 100% of the topical formalin group after a median (range) of 2 (1-5) sessions of either treatment. After a follow-up duration of 111 (29-170) months, only 1 patient in each group needed further treatment. Reductions in rectal compliance and volumes of sensory perception occurred after APC, but no effect on anorectal symptoms other than rectal bleeding was observed. There were no differences between APC and topical formalin for anorectal symptoms and function, nor for anal sphincteric morphology. Conclusions: Argon plasma coagulation and topical formalin had comparable efficacy in the durable control of rectal bleeding associated with chronic radiation proctitis but had no beneficial effect on anorectal dysfunction.

  7. Argon Plasma Coagulation Therapy Versus Topical Formalin for Intractable Rectal Bleeding and Anorectal Dysfunction After Radiation Therapy for Prostate Carcinoma

    International Nuclear Information System (INIS)

    Yeoh, Eric; Tam, William; Schoeman, Mark; Moore, James; Thomas, Michelle; Botten, Rochelle; Di Matteo, Addolorata

    2013-01-01

    Purpose: To evaluate and compare the effect of argon plasma coagulation (APC) and topical formalin for intractable rectal bleeding and anorectal dysfunction associated with chronic radiation proctitis. Methods and Materials: Thirty men (median age, 72 years; range, 49-87 years) with intractable rectal bleeding (defined as ≥1× per week and/or requiring blood transfusions) after radiation therapy for prostate carcinoma were randomized to treatment with APC (n=17) or topical formalin (n=13). Each patient underwent evaluations of (1) anorectal symptoms (validated questionnaires, including modified Late Effects in Normal Tissues–Subjective, Objective, Management, and Analytic and visual analogue scales for rectal bleeding); (2) anorectal motor and sensory function (manometry and graded rectal balloon distension); and (3) anal sphincteric morphology (endoanal ultrasound) before and after the treatment endpoint (defined as reduction in rectal bleeding to 1× per month or better, reduction in visual analogue scales to ≤25 mm, and no longer needing blood transfusions). Results: The treatment endpoint was achieved in 94% of the APC group and 100% of the topical formalin group after a median (range) of 2 (1-5) sessions of either treatment. After a follow-up duration of 111 (29-170) months, only 1 patient in each group needed further treatment. Reductions in rectal compliance and volumes of sensory perception occurred after APC, but no effect on anorectal symptoms other than rectal bleeding was observed. There were no differences between APC and topical formalin for anorectal symptoms and function, nor for anal sphincteric morphology. Conclusions: Argon plasma coagulation and topical formalin had comparable efficacy in the durable control of rectal bleeding associated with chronic radiation proctitis but had no beneficial effect on anorectal dysfunction

  8. Time patterns of changes in biomarkers, symptoms and histopathology during pelvic radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Larsen, Annette; Dahl, Olav [Section of Oncology, Institute of Medicine, Univ. of Bergen, and Dept. of Oncology, Haukeland Univ. Hospital, Bergen (Norway); Bjoerge, Benedikte; Klementsen, Beate [National Institute of Nutrition and Seafood Research, Bergen (Norway); Helgeland, Lars [Dept. of Pathology, Haukeland Univ. Hospital, Bergen (Norway); Wentzel-Larsen, Tore [Centre for Clinical Research, Haukeland Univ. Hospital, Bergen (Norway); Fagerhol, Magne K. [Dept. of Immunology and Transfusion Medicine, Ullevaal Univ. Hospital, Oslo (Norway); Hovdenak, Nils [Dept. of Medicine, Haukeland Univ. Hospital, Bergen (Norway)

    2007-07-15

    Acute radiation proctitis was evaluated before, during and after radiotherapy (RT) for prostate cancer. The main aims of the study were to examine changes related to the increasing radiation dose, and identify surrogate markers of gastrointestinal (GI) reaction to radiation. Twenty consecutive prostate cancer patients scheduled for 7 weeks of conformal RT were prospectively included in a longitudinal study assessing symptoms, inflammation in rectal mucosa biopsies, and blood and stool samples at four time points (before RT and 2, 6 and 11 weeks after start of RT). Blood samples were examined for acute phase response-related markers, fatty acids (FAs), vitamin E and leukotriene B4 (LTB4). Lactoferrin, calprotectin and S100A12 were measured in stool samples and FAs in biopsies from rectal mucosa. The increase in histopathological inflammation reached a maximum 2 weeks after start of RT. Symptoms of GI toxicity increased with higher radiation dose and had not returned to pre-treatment level 4 weeks after RT. Lactoferrin concentrations in stool increased significantly at week 6. Significant decreases of vitamin E, leukocyte count, hemoglobin and some groups of FAs were discovered, while a few FAs increased significantly during the study period. Time courses vary between the selected indicators of acute radiation proctitis. The biopsy grading of inflammatory changes were most intense 2 weeks into the treatment period while symptoms continued to increase until week 6. Lactoferrin in stool samples could be a non-invasive marker of GI inflammation during RT. A transient decrease in vitamin E and some FAs during RT warrants further studies.

  9. Postoperative irradiation of endometrial cancer by iridium afterloading technique

    International Nuclear Information System (INIS)

    Kucera, H.; Weghaupt, K.

    1988-01-01

    From 1981 to 1986 708 patients were operated and postoperativly treated by total hysterectomy, bilateral salpingo-oophorectomy and postoperative vaginal irradiation with high-dose-afterloading (iridium 192). A percutaneous irradiation (cobalt 60) was done in stage I cases only when myometrial infiltration was deep. Highly differentiated tumors with infiltration of the first and second thirth of the myometrium were treated by vaginal irradiation alone. Poorly differentiated tumors with infiltration of the second and third thirth of the myometrium were treated by vaginal and percutaneous irradiation. A group of 125 cases with good prognosis and with postoperative vaginal irradiation alone had the same five-year-survival of 83% as a group of 152 cases with bad prognosis treated by vaginal and percutaneous irrradiation. This result shows clearly the importance of additional irradiation of the pelvis in cases with bad prognosis factors. The incidence of radiation side effect in all 708 cases was: cystitis 4.6%, proctitis 5.2%, vaginal or rectal ulcera 1.4% and fistulas 0.2%. Cases with vaginal irradiation alone and with the optimal intravaginal fraction dose of 700 cGy (twice) had the lowest level of side effects: cystitis 3.8% proctitis 2.1%, vaginal necrosis 0.7%, no further severe complications. None of the patients with postoperative vaginal irradiation alone had a vaginal recurrence. The incidence of recurrences in 708 patients was 1.6%. All recurrence cases in stage I (0.7%) had bad prognosis factors and were treated with vaginal and percutaneous irradiation. (orig./MG) [de

  10. Rectal budesonide and mesalamine formulations in active ulcerative proctosigmoiditis: efficacy, tolerance, and treatment approach

    Directory of Open Access Journals (Sweden)

    Christophi GP

    2016-05-01

    Full Text Available George P Christophi, Arvind Rengarajan, Matthew A Ciorba Division of Gastroenterology, Washington University School of Medicine, St. Louis, MO, USA Abstract: Ulcerative colitis (UC is an immune-mediated disease of the colon that is characterized by diffuse and continuous inflammation contiguous from the rectum. Half of UC patients have inflammation limited to the distal colon (proctitis or proctosigmoiditis that primarily causes symptoms of bloody diarrhea and urgency. Mild-to-moderate distal UC can be effectively treated with topical formulations (rectal suppositories, enemas, or foam of mesalamine or steroids to reduce mucosal inflammation and alleviate symptoms. Enemas or foam formulations adequately reach up to the splenic flexure, have a minimal side-effect ­profile, and induce remission alone or in combination with systemic immunosuppressive therapy. Herein, we compare the efficacy, cost, patient tolerance, and side-effect profiles of steroid and mesalamine rectal formulations in distal UC. Patients with distal mild-to-moderate UC have a remission rate of approximately 75% (NNT =2 after treatment for 6 weeks with mesalamine enemas. Rectal budesonide foam induces remission in 41.2% of patients with mild-to-moderate active distal UC compared to 24% of patient treated with placebo (NNT =5. However, rectal budesonide has better patient tolerance profile compared to enema formulations. Despite its favorable efficacy, safety, and cost profiles, patients and physicians significantly underuse topical treatments for treating distal colitis. This necessitates improved patient education and physician familiarity regarding the indications, effectiveness, and potential financial and tolerability barriers in using rectal formulations. Keywords: inflammatory bowel disease, treatment cost effectiveness, Crohn’s disease, ulcerative colitis, colon mucosa, proctitis suppositories, topical immunosuppressive therapy

  11. Implication of endothelial to mesenchymal cell transition in the development of healthy digestive tissue injury following radiotherapy

    International Nuclear Information System (INIS)

    Mintet, Elodie

    2015-01-01

    Fibrosis is identified as a chronic side effect occurring after radiotherapy for pelvic tumors in 5 to 10 % of patients. This pathological healing process is characterized by an accumulation of extracellular matrix synthesized by mesenchymal cells. Endothelial to mesenchymal transition (EndoMT), is a processes during which endothelial cells express mesenchymal markers in response to stress. EndoMT is identified as a new source of mesenchymal cells taking part to fibrosis development in patients suffering from inflammatory bowel diseases. Then, this study focused on the potential participation of EndoMT in radiation-induced intestinal fibrosis and tried to identify new therapeutics targets. Interestingly, our results showed for the first time EndoMT in rectal tissues from patients who developed radiation proctitis following radiotherapy. We used an in vivo approach to follow the mesenchymal cells having an endothelial origin in a mouse model expressing the GFP under the control of an endothelial promoter, Tie2 (Tie2-GFP). Thereby, our results confirmed the existence of radiation-induced EndoMT in our preclinical model of radiation proctitis. In vitro characterization showed that irradiation induced a modulation of the endothelial phenotype through a mesenchymal profile, a hallmark of EndoMT. This project also focused on a potential molecular actor, Hey2. In this context, we generated a transgenic mouse model in which Hey2 gene expression is repressed specifically in the endothelial compartment and observed a decrease in radiation-induced mucosal damages and EndoMT frequency. Consequently, inhibiting Hey2 expression could represent a new interesting therapeutic strategy. (author)

  12. Dosimetric Coverage of the Prostate, Normal Tissue Sparing, and Acute Toxicity with High-Dose-Rate Brachytherapy for Large Prostate Volumes

    Directory of Open Access Journals (Sweden)

    George Yang

    2015-06-01

    Full Text Available ABSTRACTPurposeTo evaluate dosimetric coverage of the prostate, normal tissue sparing, and acute toxicity with HDR brachytherapy for large prostate volumes.Materials and MethodsOne hundred and two prostate cancer patients with prostate volumes >50 mL (range: 5-29 mL were treated with high-dose-rate (HDR brachytherapy ± intensity modulated radiation therapy (IMRT to 4,500 cGy in 25 daily fractions between 2009 and 2013. HDR brachytherapy monotherapy doses consisted of two 1,350-1,400 cGy fractions separated by 2-3 weeks, and HDR brachytherapy boost doses consisted of two 950-1,150 cGy fractions separated by 4 weeks. Twelve of 32 (38% unfavorable intermediate risk, high risk, and very high risk patients received androgen deprivation therapy. Acute toxicity was graded according to the Common Terminology Criteria for Adverse Events (CTCAE version 4.ResultsMedian follow-up was 14 months. Dosimetric goals were achieved in over 90% of cases. Three of 102 (3% patients developed Grade 2 acute proctitis. No variables were significantly associated with Grade 2 acute proctitis. Seventeen of 102 (17% patients developed Grade 2 acute urinary retention. American Urological Association (AUA symptom score was the only variable significantly associated with Grade 2 acute urinary retention (p=0.04. There was no ≥ Grade 3 acute toxicity.ConclusionsDosimetric coverage of the prostate and normal tissue sparing were adequate in patients with prostate volumes >50 mL. Higher pre-treatment AUA symptom scores increased the relative risk of Grade 2 acute urinary retention. However, the overall incidence of acute toxicity was acceptable in patients with large prostate volumes.

  13. Clinical predictors of rectal lymphogranuloma venereum infection: results from a multicentre case–control study in the UK

    Science.gov (United States)

    Pallawela, S N S; Sullivan, A K; Macdonald, N; French, P; White, J; Dean, G; Smith, A; Winter, A J; Mandalia, S; Alexander, S; Ison, C; Ward, H

    2014-01-01

    Objective Since 2003, over 2000 cases of lymphogranuloma venereum (LGV) have been diagnosed in the UK in men who have sex with men (MSM). Most cases present with proctitis, but there are limited data on how to differentiate clinically between LGV and other pathology. We analysed the clinical presentations of rectal LGV in MSM to identify clinical characteristics predictive of LGV proctitis and produced a clinical prediction model. Design A prospective multicentre case–control study was conducted at six UK hospitals from 2008 to 2010. Cases of rectal LGV were compared with controls with rectal symptoms but without LGV. Methods Data from 98 LGV cases and 81 controls were collected from patients and clinicians using computer-assisted self-interviews and clinical report forms. Univariate and multivariate logistic regression was used to compare symptoms and signs. Clinical prediction models for LGV were compared using receiver operating curves. Results Tenesmus, constipation, anal discharge and weight loss were significantly more common in cases than controls. In multivariate analysis, tenesmus and constipation alone were suggestive of LGV (OR 2.98, 95% CI 0.99 to 8.98 and 2.87, 95% CI 1.01 to 8.15, respectively) and that tenesmus alone or in combination with constipation was a significant predictor of LGV (OR 6.97, 95% CI 2.71 to 17.92). The best clinical prediction was having one or more of tenesmus, constipation and exudate on proctoscopy, with a sensitivity of 77% and specificity of 65%. Conclusions This study indicates that tenesmus alone or in combination with constipation makes a diagnosis of LGV in MSM presenting with rectal symptoms more likely. PMID:24687130

  14. Hypervirulent Chlamydia trachomatis Clinical Strain Is a Recombinant between Lymphogranuloma Venereum (L2) and D Lineages

    Science.gov (United States)

    Somboonna, Naraporn; Wan, Raymond; Ojcius, David M.; Pettengill, Matthew A.; Joseph, Sandeep J.; Chang, Alexander; Hsu, Ray; Read, Timothy D.; Dean, Deborah

    2011-01-01

    ABSTRACT Chlamydia trachomatis is an obligate intracellular bacterium that causes a diversity of severe and debilitating diseases worldwide. Sporadic and ongoing outbreaks of lymphogranuloma venereum (LGV) strains among men who have sex with men (MSM) support the need for research on virulence factors associated with these organisms. Previous analyses have been limited to single genes or genomes of laboratory-adapted reference strain L2/434 and outbreak strain L2b/UCH-1/proctitis. We characterized an unusual LGV strain, termed L2c, isolated from an MSM with severe hemorrhagic proctitis. L2c developed nonfusing, grape-like inclusions and a cytotoxic phenotype in culture, unlike the LGV strains described to date. Deep genome sequencing revealed that L2c was a recombinant of L2 and D strains with conserved clustered regions of genetic exchange, including a 78-kb region and a partial, yet functional, toxin gene that was lost with prolonged culture. Indels (insertions/deletions) were discovered in an ftsK gene promoter and in the tarp and hctB genes, which encode key proteins involved in replication, inclusion formation, and histone H1-like protein activity, respectively. Analyses suggest that these indels affect gene and/or protein function, supporting the in vitro and disease phenotypes. While recombination has been known to occur for C. trachomatis based on gene sequence analyses, we provide the first whole-genome evidence for recombination between a virulent, invasive LGV strain and a noninvasive common urogenital strain. Given the lack of a genetic system for producing stable C. trachomatis mutants, identifying naturally occurring recombinants can clarify gene function and provide opportunities for discovering avenues for genomic manipulation. PMID:21540364

  15. Clinical predictors of rectal lymphogranuloma venereum infection: results from a multicentre case-control study in the U.K.

    Science.gov (United States)

    Pallawela, S N S; Sullivan, A K; Macdonald, N; French, P; White, J; Dean, G; Smith, A; Winter, A J; Mandalia, S; Alexander, S; Ison, C; Ward, H

    2014-06-01

    Since 2003, over 2000 cases of lymphogranuloma venereum (LGV) have been diagnosed in the U.K. in men who have sex with men (MSM). Most cases present with proctitis, but there are limited data on how to differentiate clinically between LGV and other pathology. We analysed the clinical presentations of rectal LGV in MSM to identify clinical characteristics predictive of LGV proctitis and produced a clinical prediction model. A prospective multicentre case-control study was conducted at six U.K. hospitals from 2008 to 2010. Cases of rectal LGV were compared with controls with rectal symptoms but without LGV. Data from 98 LGV cases and 81 controls were collected from patients and clinicians using computer-assisted self-interviews and clinical report forms. Univariate and multivariate logistic regression was used to compare symptoms and signs. Clinical prediction models for LGV were compared using receiver operating curves. Tenesmus, constipation, anal discharge and weight loss were significantly more common in cases than controls. In multivariate analysis, tenesmus and constipation alone were suggestive of LGV (OR 2.98, 95% CI 0.99 to 8.98 and 2.87, 95% CI 1.01 to 8.15, respectively) and that tenesmus alone or in combination with constipation was a significant predictor of LGV (OR 6.97, 95% CI 2.71 to 17.92). The best clinical prediction was having one or more of tenesmus, constipation and exudate on proctoscopy, with a sensitivity of 77% and specificity of 65%. This study indicates that tenesmus alone or in combination with constipation makes a diagnosis of LGV in MSM presenting with rectal symptoms more likely. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  16. Dosimetric coverage of the prostate, normal tissue sparing, and acute toxicity with high-dose-rate brachytherapy for large prostate volumes

    Energy Technology Data Exchange (ETDEWEB)

    Yang, George; Strom, Tobin J.; Shrinath, Kushagra; Mellon, Eric A.; Fernandez, Daniel C.; Biagioli, Matthew C. [Department of Radiation Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL (United States); Wilder, Richard B., E-mail: mcbiagioli@yahoo.com [Cancer Treatment Centers of America, Newnan, GA (United States)

    2015-05-15

    Purpose: to evaluate dosimetric coverage of the prostate, normal tissue sparing, and acute toxicity with HDR brachytherapy for large prostate volumes. Materials and methods: one hundred and two prostate cancer patients with prostate volumes >50 mL (range: 5-29 mL) were treated with high-dose-rate (HDR) brachytherapy ± intensity modulated radiation therapy (IMRT) to 4,500 cGy in 25 daily fractions between 2009 and 2013. HDR brachytherapy monotherapy doses consisted of two 1,350-1,400 cGy fractions separated by 2-3 weeks, and HDR brachytherapy boost doses consisted of two 950-1,150 cGy fractions separated by 4 weeks. Twelve of 32 (38%) unfavorable intermediate risk, high risk, and very high risk patients received androgen deprivation therapy. Acute toxicity was graded according to the Common Terminology Criteria for Adverse Events (CTCAE) version 4. Results: median follow-up was 14 months. Dosimetric goals were achieved in over 90% of cases. Three of 102 (3%) patients developed Grade 2 acute proctitis. No variables were significantly associated with Grade 2 acute proctitis. Seventeen of 102 (17%) patients developed Grade 2 acute urinary retention. American Urological Association (AUA) symptom score was the only variable significantly associated with Grade 2 acute urinary retention (p-0.04). There was no ≥ Grade 3 acute toxicity. Conclusions: dosimetric coverage of the prostate and normal tissue sparing were adequate in patients with prostate volumes >50 mL. Higher pre-treatment AUA symptom scores increased the relative risk of Grade 2 acute urinary retention. However, the overall incidence of acute toxicity was acceptable in patients with large prostate volumes. (author)

  17. Traducción, adaptación y validación al español del cuestionario de calidad de vida de 32 ítems (IBDQ-32 de la enfermedad inflamatoria intestinal Spanish translation, adaptation, and validation of the 32-item questionnaire on quality of life for inflammatory bowel disease (IBDQ-32

    Directory of Open Access Journals (Sweden)

    M. Masachs

    2007-09-01

    Full Text Available Introducción: la medida de la calidad de vida relacionada con la salud (CVRS tiene una reconocida importancia en la evaluación, el manejo y el seguimiento de la enfermedad inflamatoria intestinal. El instrumento de medida más utilizado es la versión de 32 ítems del Inflammatory Bowel Disease Questionnaire (IBDQ-32, que no está adaptado al español. Objetivo: traducir la versión del IBDQ-32 al español y determinar su validez, fiabilidad y sensibilidad tanto en la colitis ulcerosa como en la enfermedad de Crohn. Método: estudio prospectivo en dos fases: traducción y posterior validación del IBDQ-32 al español. La traducción se ha basado en la versión al español validada del IBDQ-36, y los ítems del IBDQ-32 no incluidos en el IBDQ-36 se tradujeron "de novo". Una vez terminada la traducción del IBDQ32, se aplicó un cuestionario específico de comprensión. Para determinar las propiedades psicométricas del IBDQ-32, un grupo de pacientes completó el IBDQ-36 ya validado al español y el IBDQ-32. Resultados: se han incluido 84 pacientes (53 con enfermedad de Crohn y 31 con colitis ulcerosa. La mediana de la puntuación global de ambos cuestionarios en los 84 pacientes no fue diferente (6,1 vs. 6,2, p = ns y su correlación de Spearman fue muy significativa (r = 0,97, p Introduction: the measurement of health-related quality of life (HRQoL has an established relevance in the assessment, management, and follow-up of inflammatory bowel disease. The most commonly used measuring instrument is the 32-item version of Inflammatory Bowel Disease Questionnaire (IBDQ-32, which has never been adapted to Spanish. Objective: to translate IBDQ-32 into Spanish, and to establish its validity, reliability, and sensitivity both in ulcerative colitis and Crohn's disease. Method: a prospective study in two phases -translation into Spanish and subsequent validation of IBDQ-32. Translation was based on the validated Spanish version of IBDQ-36, and IBDQ-32

  18. Efecto del hialuronato de zinc sobre las úlceras en pacientes con diabetes

    Directory of Open Access Journals (Sweden)

    Fernando Ramos Cuevas

    por grupo. Resultados: La glucemia promedio al ingresar al estudio fue de 163,64 ± 86,4 mg/dl en el grupo del hialuronato de zinc, por 182,4 ± 68,3 mg/dl del otro grupo, NS. El área de la úlcera al inicio del estudio en promedio fue de 13,28 ± 11,8 cm² en los pacientes tratados con hialuronato de zinc por 7 ± 5,3 cm² entre aquellos manejados en forma convencional, p= 0,01. El tiempo de cierre de la lesión ulcerosa en promedio fue 7,80 ± 3,49 semanas en los 25 pacientes del grupo con hialuronato de zinc, mientras que sólo en dos casos del grupo con tratamiento convencional se observó cierre de la lesión ulcerosa al cabo de 12 semanas de seguimiento (uno siete y el otro nueve semanas. Conclusiones: El hialuronato de zinc representa la primera opción terapéutica en el tratamiento de las úlceras de pacientes diabéticos.

  19. Spiral CT colonography in inflammatory bowel disease

    International Nuclear Information System (INIS)

    Tarjan, Zsolt; Zagoni, Tamas; Gyoerke, Tamas; Mester, Adam; Karlinger, Kinga; Mako, Erno K.

    2000-01-01

    Objective: Most of the studies on virtual colonoscopy are dealing with the role of detecting colorectal polyps or neoplasms. We have undertaken this study to evaluate the value of CT colonography in patients with colonic Crohn's disease. Methods and material: Five patients (three males, two females, 23-51 years, mean age 42 years) with known (4) or suspected (1) Crohn's disease of the colon underwent fiberoptic colonoscopy and CT colonography in the same day or during a 1-week period. The images were evaluated with the so called zoomed axial slice movie technique and in some regions intra- and extraluminal surface shaded and volume rendered images were generated on a separate workstation. The results were compared to those of a colonoscopy. Results: The final diagnosis was Crohn's disease in four patients and colitis ulcerosa in one. Total examination was possible by colonoscopy in two cases, and with CT colonography in all five cases. The wall of those segments severely affected by the disease were depicted by the axial CT scans to be thickened. The thick walled, segments with narrow lumen seen on CT colonography corresponded to the regions where colonoscopy was failed to pass. Air filled sinus tracts, thickening of the wall of the terminal ileum, loss of haustration pseudopolyps and deep ulcers were seen in CT colonography. Three dimensional (3D) endoluminal views demonstrated pseudopolyps similar to endoscopic images None of the colonoscopically reported shallow ulcerations or aphtoid ulcerations or granular mucosal surface were observed on 2- or 3D CT colonographic images. Conclusion: CT colonography by depicting colonic wall thickening seems to be a useful tool in the diagnosis of Crohn's colitis, which could be a single examination depicting the intraluminal, and transmural extent of the disease

  20. The oxygen-centered radicals scavenging activity of sulfasalazine and its metabolites. A direct protection of the bowel.

    Science.gov (United States)

    Prónai, L; Yukinobu, I; Láng, I; Fehér, J

    1992-01-01

    Oxygen-centered radicals, such as superoxide (O2-) and hydroxyl radicals (.OH) generated by phagocytes have been suggested to be involved in the pathogenesis of chronic inflammations of the bowel, such as Crohn's disease and colitis ulcerosa. Recently, sulfasalazine (SASP) and its metabolites have been reported to exert their effects as a direct scavenger of oxygen-centered radicals in the bowel. To scavenge oxygen-centered radicals in vivo, however, SASP and its metabolites have to react with O2- and/or .OH in vitro very rapidly, furthermore they have to reach an appropriate (possible millimolar) concentration range at the site of inflammation. To test this possibility, we investigated the direct O2- and .OH scavenging activity of SASP and its metabolites using the specific electron paramagnetic resonance/spin trapping method, and we compared the 50% inhibition rates of SASP and its metabolites with their known concentrations in the bowel and in the human plasma. It was found that SASP and its metabolites, such as 5-amino-salicylic acid (5-ASA), and acetyl-5-amino-salicylic acid (AC-5-ASA), but not sulfapyridine (SP) and acetyl-sulfapyridine (Ac-SP) have a direct O2- and .OH scavenging activity in vitro systems. Among the compounds, SASP and 5-ASA can reach a concentration which is appropriate to scavenge oxygen-centered radicals in the bowel but not in the human plasma. It was concluded that the in vivo antiinflammatory effects of SASP and its metabolites are, at least partly, due to the direct oxygen-centered scavenging activity of these drugs.

  1. [Low-intensity, evidence-based cognitive-behavioural therapy of a patient with Crohn's disease].

    Science.gov (United States)

    Antal-Uram, Dóra; Harsányi, László; Perczel-Forintos, Dóra

    2018-03-01

    Inflammatory bowel disease (Crohn's disease and colitis ulcerosa) is a chronic, long-term condition that causes chronic inflammation in the digestive tract, and shows an increasing incidence and prevalence worldwide. Changes in disease activity over time affect psychological distress which increases the risk of exacerbations. Beside somatic symptoms (such as abdominal pain, diarrhoea and weight loss), psychiatric comorbidity (in particular major depression, anxiety, social phobia) is common in patients with Crohn's disease. This case study illustrates the management and stabilization of a 21-year-old adult male patient with active Crohn's disease and with severe psychiatric comorbidity. The patient was diagnosed with avoidant personality disorder and dysruptive mood dysregulation disorder based on the results of psychodiagnostics (SCID-II structured clinical interview, MMPI personality inventory and disease-specific clinical questionnaires such as Beck Depression Inventory, Beck Hopelessness Scale, Social Cognition Questionnaire, Anger Expression Scale, Cognitive Emotion Regulation Questionnaire, Rosenberg Self-Esteem Scale). The main aim of psychotherapy is to increase the adherence to pharmacotherapy, to promote psychosocial functioning, to improve well-being and to enhance adaptive coping strategies. Low-intensity cognitive-behavioural psychotherapy was used which included psychoeducation, motivational interview, behavioural activation, patient diary, cognitive restructuring, problem-solving training, and family consulting. Twenty-five sessions were held weekly in outpatient form and 3 sessions of crisis intervention after the surgery at the hospital. The efficacy of the treatment was measured by self-reported questionnaires at baseline and at two follow-up sessions which corroborated a very significant decrease in the severity of depression, hopelessness, while emotional regulation and self-esteem became more adaptive. The remission of the above

  2. Variable frequency harmonic vibration suppression using active vibration absorption

    Directory of Open Access Journals (Sweden)

    Francisco Beltrán-Carbajal

    2014-01-01

    Full Text Available Los absorbedores dinámicos pasivos de vibraciones se han utilizado ampliamente para atenuación de vibraciones dañinas en muchos sistemas de ingeniería prácticos. La aplicabilidad de estos dispositivos de absorción pasiva de vibraciones se limita a un ancho de banda angosto y especifico de frecuencias de operación. En este artículo se propone un nuevo esquema de absorción activa de vibraciones que permite extender la capacidad de supresión de vibraciones de un absorbedor masa-resorte-amortiguador pasivo para cualquier frecuencia de excitación, incluyendo fuerzas de perturbación armónica resonantes de interés. Los fundamentos centrales de un absorbedor pasivo se explotan en la etapa de diseño del esquema de absorción propuesto. Así, el dispositivo de absorción activa aplica fuerzas sobre el sistema mecánico primario que contrarrestan las fuerzas de perturbación desconocidas, conservando la propiedad de atenuación de vibraciones del absorbedor pasivo. La fuerza de perturbación se estima en línea usando un observador de estado extendido propuesto en este trabajo. Se incluyen resultados en simulación para mostrar la eficiencia del esquema de absorción activa de vibraciones para rechazar vibraciones forzadas resonantes y caóticas completamente desconocidas afectando el sistema mecánico primario, y para probar la efectividad de la estimación de fuerzas de perturbación exógenas.

  3. Els projectes d'innovació com a recurs formatiu en el Màster del Professorat

    Directory of Open Access Journals (Sweden)

    Isabel María Gómez Trigueros

    2017-12-01

    Full Text Available Los cambios producidos en todos los ámbitos de la vida como consecuencia del desarrollo de la Sociedad de la Información y la Comunicación tiene su reflejo en la Educación Superior y en la necesaria adaptación tanto de los planes de estudio como de la formación del profesorado estas nuevas necesidades. En este sentido, desde el Espacio Europeo de Educación Superior se aboga por la formación en competencias así como por la implementación de metodologías activas con tecnología. En este estudio se propone la utilización de una metodología eminentemente activa, cooperativa y con tecnologías para la construcción de proyectos de innovación educativa como recurso para el desarrollo de buenas prácticas formativas. Se propone un análisis de tipo exploratorio descriptivo a través de un cuestionario escala Likert centrado en constatar las potencialidades de dicha estrategia de aula en la formación tecnológico-pedagógica docente para estudiantes de Máster del Profesorado. Los resultados presentan la percepción de la muestra respecto a la ausencia en la implementación de metodologías activas y a la incorrecta inclusión de las tecnologías en las prácticas de aula. Se concluye con una serie de consideraciones en la formación del profesorado.

  4. Propuesta pedagógica de las Exploradoras y las Guías italianas

    OpenAIRE

    Bosna, Valeria Vittoria Aurora; Rodríguez, María Luisa García

    2011-01-01

    El escultismo, movimiento juvenil iniciado en 1907 en Inglaterra porRobert Baden Powell, tiene como fin para sus miembros femeninoshacer descubrir a las chicas y a las mujeres jóvenes su lugar en elconjunto de seres de la creación, prepararlas para realizar su vocaci-ón manteniéndose fieles a la Ley y a la Promesa scouts, y dirigirlashacia una presencia activa en la comunidad. El mensaje de BadenPowell ha recibido distintas interpretaciones al ser mirado desde di-ferentes perspectivas, a trav...

  5. Reggio Emilia: una manera diferente de trabajar en Educaci??n Infantil

    OpenAIRE

    Bueno Rodr??guez, Isabel Mar??a

    2015-01-01

    El enfoque de atenci??n educativa a la infancia de Reggio Emilia es una forma de interpretar la educaci??n que surge despu??s de la Segunda Guerra Mundial, del deseo de un pueblo de cambiar la sociedad. Loris Malaguzzi es considerado el impulsor y creador de esta pedagog??a, basada en la escucha activa, interpretada ??sta como la habilidad de comprender al ni??o en sus cien lenguajes. Y de esta visi??n del ni??o, surge el atelier y atelierista, otra de las se??as de identidad de esta pedagog?...

  6. La atenci??n educativa a la infancia de Reggio Emilia: an??lisis de su implementaci??n en Espa??a

    OpenAIRE

    Cano Lebr??n, Eva Mar??a

    2015-01-01

    Este estudio de caso explora la experiencia educativa de Reggio Emilia en Espa??a. Se trata de unas escuelas que tienen su origen en el norte de Italia, pero que se han convertido en un fen??meno educativo conocido internacionalmente. Reggio Emilia comparte una filosof??a educativa innovadora, donde el ni??o es el centro de todo el proceso educativo. En estas escuelas se defiende una educaci??n activa, participativa y de escucha, donde se da gran importancia al ambiente, a la documentaci??n, ...

  7. La enseñanza de nociones especiales a través de mapas y planos en educación infantil: una propuesta de intervención

    OpenAIRE

    Clérigo García, Natalia

    2014-01-01

    El presente trabajo pretende poner de manifiesto la importancia de la enseñanza de nociones espaciales en el segundo ciclo de educación infantil. Por ello, se ha llevado a cabo una propuesta de intervención educativa puesta en práctica en un aula de infantil, basada en la enseñanza de nociones espaciales a través de mapas y planos, de una forma amena, lúdica, activa y participativa, con experiencias enriquecedoras a través de actividades vividas por ellos mismos y en continuo contacto con la ...

  8. Las inteligencias múltiples en el aula de Educación Infantil.

    OpenAIRE

    Sancho-Álvarez, Carlos; Grau Vidal, Roser

    2012-01-01

    Vivimos en un mundo globalizado, cambiante y que cada día avanza más rápido. La escuela debe fomentar orientaciones y aprendizajes que se vayan adaptando al transcurso de la actualidad. Gracias a la teoría de las Inteligencias Múltiples de Howard Gardner (Harvard University), podemos ofrecer diferentes rutas y mapas escolares que se adapten a las necesidades educativas de cada alumno y alumna de forma integral en base a una metodología activa. El presente documento se ha diseña...

  9. Herramientas innovadoras para futuros docentes de enseñanza Secundaria: El Ministerio del Tiempo como herramienta metodológica interdicisplinar

    OpenAIRE

    Ruiz Bañuls, Mónica; Gómez Trigueros, Isabel María

    2017-01-01

    El propósito de esta comunicación es presentar un trabajo que se inserta dentro de la RED: “Propuestas transmedia y gamificación aplicadas al EEES: nuevas metodología activas para implementar las competencias en Ciencias Sociales y en Literatura”. La idea que sustenta la RED es considerar las TIC como un espacio decisivo para la difusión de la docencia a través de herramientas virtuales, desarrollando propuestas didácticas en las que se implemente a través de los transmedia y la gamificación ...

  10. Modulador-Demodulador ASK con codificación Manchester implementado en un microcontrolador PIC

    OpenAIRE

    Tarifa Amaya, Ariel; Del Risco Sánchez, Arnaldo; Cruz Hurtado, Juan Carlos

    2012-01-01

    Se presenta el diseño de un Modulador-Demodulador Digital ASK con codificación Manchester implementado en el firmware de un microcontrolador PIC 18F4455, utilizando el estándar de baja frecuencia (LF) el cual maneja valores de 125kHz. Este modulador-demodulador se utiliza en la implementación de una etiqueta RFID activa. Transmite a solicitud de un dispositivo lector el valor de temperatura de un sensor y su identificador. El dispositivo lector, controla la comunicación con la etiqueta. Según...

  11. Una experiencia didáctica con el collage.

    Directory of Open Access Journals (Sweden)

    Joaquim Cantalozella Planas

    2008-07-01

    Full Text Available El punto de partida que Joan Miró estableció para realizar las dieciocho Pintures segons collage de 1933 nos sirven hoy para hacer una propuesta que permita pensar en algunas de las claves de la pintura contemporánea. Términos como la apropiación, la autoría o la subjetividad del artista se ponen en juego cuando se activa el dispositivo del collage como modelo. Aquí se plantea una actividad de aprendizaje que confronta el trabajo individual con el colectivo y que tiene como objetivo principal la reflexión sobre el lenguaje pictórico.

  12. Atar a la sociedad: adolescencia, riesgo y población en la primera mitad del siglo XX

    OpenAIRE

    Ariza Montañez, Vladimir Alejandro

    2012-01-01

    En el marco de las reformas a la educación normalista y secundaria del país por los años 30 y 50 del siglo XX, orientadas por la apropiación de pedagogías activas y los saberes modernos que las sustentaron –psicología, psicoanálisis, biología, fisiología, higiene, medicina, criminología, saberes sociales- surgieron una serie de discursos sobre la adolescencia. La presente investigación busca dar cuenta de la apropiación de dicho concepto-objeto. Definida como una etapa transitoria, sexuada y ...

  13. Sentarse, escuchar y repetir. ¿Existe otra forma de enseñar historia?

    Directory of Open Access Journals (Sweden)

    Laura Bécares Rodríguez

    2016-06-01

    Full Text Available La asignatura de Ciencias Sociales, debido a su gran carga teórica y a la abstracción de los conceptos a estudiar, genera una gran desmotivación en el alumnado de educación primaria y secundaria. En este artículo proponemos el uso de las metodologías activas como sistema para la implicación de los estudiantes en la asignatura. Para ello exponemos la base teórica que avala estas teorías y presentamos propuestas concretas para su aplicación en el aula.

  14. Eficacia de la infiltración de ozono paravertebral lumbar y en puntos gatillos como coadyuvante del tratamiento en pacientes con dolor lumbar crónico y lumbociatalgia crónica en el síndrome doloroso miofascial aislado o acompañado de otras patologías

    OpenAIRE

    E. Silva Jiménez; M. Toro; C. Baíz

    2014-01-01

    Introducción: Posterior al primer episodio de dolor lumbar, la recurrencia persiste durante un año o más en el 25 al 60 %, afectando a población económicamente activa, causando discapacidad y en 80 % ausentismo laboral. Objetivo: Evaluar el grado de eficacia del uso de la técnica de infiltración con ozono paravertebral lumbar y en puntos gatillos junto al tratamiento farmacológico y rehabilitador, en pacientes con dolor lumbar crónico y lumbociatalgia crónica debido al síndrome doloroso miofa...

  15. El análisis histórico del trabajo agrario : cuestiones recientes

    OpenAIRE

    Sarasúa García, Carmen

    2000-01-01

    Este artículo analiza algunas de las principales contribuciones hechas en la última década al estudio de la organización del trabajo agrícola. Trata seis aspectos en concreto: la demanda de trabaja agrícola, los costes del trabajo, la oferta de trabaja (en especial las diferentes formas de definir y cuantificar la población `activa` del sector primario), la productividad agrícola, el marco institucional, y la estructura interna de la fuerza de trabajo agrícoia (la competencia entre los trabaj...

  16. Acção intracelular da terapia fotodinâmica

    OpenAIRE

    Cândido, Mafalda Sofia Laranjo

    2010-01-01

    Dissertação de mestrado em Biologia Celular e Molecular apresentada ao Departamento de Ciências da Vida da Faculdade de Ciências e Tecnologia da Universidade de Coimbra A terapia fotodinâmica constitui uma modalidade terapêutica que pode induzir morte celular por stresse oxidativo através da activação de um fotossensibilizador pela luz. Os sensibilizadores do tipo porfirínico têm provado ter boas características e, investigações recentes indicam que a substituição com grupos hi...

  17. Educación física en los libros de texto escolares anteriores al franquismo (II) : cartillas y manuales específicos

    OpenAIRE

    Galera, Antonio D.

    2017-01-01

    Las obras específicas para la Educación Física escolar anteriores a 1939 recomiendan como principales contenidos los juegos y la gimnasia educativa y en menor medida los paseos y excursiones, y el canto y la música; encontramos asimismo un aspecto avanzado de interdisciplinariedad: la recomendación de intercalar pausas activas entre materias no corporales, que sería recogida por el plan de 1937 de la República, pero nunca más posteriormente. No existen diferencias señaladas entre obras genera...

  18. Plan de negocio para la creación de empresa “E!- Wellness”

    OpenAIRE

    Betancourt Peláez, Sandra Milena; Guayacán Rincón, Ginna Paola; Villalba Mayorga, Marilen

    2013-01-01

    Estudio de viabilidad para la creación y puesta en marcha de la empresa E!- WELLNESS; organización que tiene como objetivo principal, prestar y ofrecer alternativas únicas y novedosas en el entorno de Bienestar Laboral Empresarial, combinando las últimas tendencias en actividades de bienestar y pausas activas para los empleados y toda una plataforma dinámica e interactiva provista por las consolas de Video Juegos y las Pantallas Led de alta resolución. Para las empresas, es un espacio pro...

  19. Factores determinantes de las conductas de riesgo para ITS - HIV en los estudiantes de las Escuelas de Salud de la Universidad Alas Peruanas, Arequipa

    OpenAIRE

    Martínez Montes, José Carlos

    2010-01-01

    Los estudiantes de las Escuelas de Salud están continuamente expuestos al riesgo de accidentes ocupacionales en los centros asistenciales, donde realizan sus prácticas, así como a una vida sexual activa, en donde el contagio por agentes infecciosos como Hepatitis B, Hepatitis C y HIV, transmisibles por mecanismos relacionados con accidentes de trabajo sanitario y relaciones sexuales entre otros, resultan como consecuencia de las conductas de riesgo, en donde el nivel de conocimientos, las act...

  20. Estudio del perfil actitudinal hacia el medio ambiente de la población limítrofe a las vías transpirenaicas de transporte por carretera en Catañuña y País Vasco-Proyecto Trans P4

    OpenAIRE

    Cacho Saldaña, Cristina

    2014-01-01

    Es innegable la estrecha relación que hay entre la sociedad y el medio ambiente y que para lograr una sociedad sostenible no sólo hay que tener sensibilidad con el medio ambiente, sino que hay que progresar hacia una ciudadanía ecológica donde los individuos sean parte activa en el cuidado del medio ambiente. El presente trabajo trata de hacer un análisis del perfil actitudinal de la población que sufre directamente los efectos perjudiciales de las principales vías transpirenaicas...

  1. Presencia de los inmigrantes españoles en la economía de la región de Santiago de Cuba (1902- 1940

    Directory of Open Access Journals (Sweden)

    M. Sc. Manuel Pevida-Pupo

    2015-10-01

    Full Text Available Los inmigrantes españoles tuvieron una activa participación en la economía de la región de Santiago de Cuba aunque no pudieron competir con los monopolios norteamericanos en sectores claves como la industria azucarera, la minería, las finanzas y los ferrocarriles; por lo que concentraron sus inversiones en el comercio, las manufacturas y la producción de bebidas, alimentos, confituras y otros artículos.

  2. Identificación de Arcobacter en niños y adultos con/sin diarrea y en reservorios animales: aves, ganado vacuno y porcino, peces y mariscos

    OpenAIRE

    Zerpa, Rito; Alarcón, Jorge; Lezama, Percy; Patiño, Lilian; Reyes, Alberto; Valencia, Augusto; Velásquez, Jorge; Alarcón, Miriam

    2013-01-01

    Objetivos: Conocer la prevalencia de Arcobacter en niños y adultos con/sin diarrea y en animales: aves, ganado vacuno y porcino, peces y mariscos. Diseño: Estudio transversal descriptivo. Institución: Instituto de Medicina Tropical Daniel A. Carrión, Facultad de Medicina, UNMSM, Instituto Nacional de Salud del Niño, Instituto Materno Infantil de San Bartolomé y Hospital Arzobispo Loayza. Material biológico: Aislamientos bacterianos de humanos y animales. Intervenciones: Búsqueda activa de Arc...

  3. La Gobernanza en la Obra de Joan Prats

    OpenAIRE

    Varela-Álvarez, Enrique José

    2011-01-01

    Gobernabilidad, gobernanza o buen gobierno, fueron estudiados en profundidad por un autor como Joan Prats, que supo compaginar su labor de investigador, divulgador y gestor a través del desarrollo de un buen número de estudios en España y América Latina, la creación de estructuras de gestión y difusión de los marcos del buen gobierno, así como la participación activa en proyectos de consultoría y docencia en cursos de directivos. La mirada que se propone en esta comunicación, contiene un sesg...

  4. Utilización de las redes sociales y de una plataforma virtual por los alumnos de la facultad de ciencias de la salud

    OpenAIRE

    Rivas Velasco, Ana; García Martínez, Olga; Luna Bertos, Elvira de; Ramos Torrecillas, Javier; Díaz Rodríguez, Lourdes

    2011-01-01

    Las redes sociales y las plataformas virtuales, tienen mucho que ver con las nuevas metodologías activas y participativas que de modo masivo se están adoptando en el Espacio Europeo de Educación Superior. El objetivo del presente trabajo fue evaluar el uso de las redes sociales y la plataforma virtual SWAD por parte del alumnado de Facultad de Ciencias de la Salud de la Universidad de Granada. En el curso 2010/2011 se ha realizado una encuesta sobre el uso de las TICs a los alu...

  5. La estrategia de la nueva extrema derecha española en Internet

    OpenAIRE

    López Ortega, Anna I.

    2016-01-01

    La gratuidad, inmediatez, anonimato y difusión que proporciona Internet es clave para analizar la estrategia de comunicación y propaganda de los partidos políticos de extrema derecha españoles. Actualmente están activas más de 90 webs vinculadas a estas formaciones y albergan más de 400 enlaces que revelan sus posibles intereses, políticos y culturales, y sus conexiones con organizaciones nacionales e internacionales con importante éxito electoral. El estudio de estas webs mediante la técnica...

  6. Aplicaciones prácticas de la espectroscopía de absorción infrarroja en el estudio de los crudos, del clínker y del cemento portland anhidro

    OpenAIRE

    Vázquez, Tomás

    1980-01-01

    En la primera parte de este trabajo (*) se trató brevemente y de una manera fundamentalmente práctica el estudio por espectroscopía infrarroja de calizas, arcillas, clínker portland y sus fases constituyentes. En, el presente trabajo finalizará esta exposición con una visión general de algunas posibilidades que tiene la espectroscopía IR en el estudio del cemento portland anhidro, así como el estudio breve de puzolanas, escorias y cenizas volantes, como adiciones activas.

  7. Criptodivisas y pagos online

    OpenAIRE

    Cuartas Micieces, Javier Alejandro

    2016-01-01

    RESUMEN: Es la fuerte base de los conceptos criptográficos en los que se apoya la seguridad del bitcoin y las criptomonedas, la que ha hecho que se mantengan activas una gran variedad de las mismas a pesar de su volatilidad. La comunidad de bitcoin debe enfrentarse aún a algunos problemas técnicos, además de la volatilidad del bitcoin y su falta de regulación, pero sigue siendo la criptomoneda más importante en el mercado. La seguridad y privacidad que brinda su tecnología, así como l...

  8. Adquisición y transmisión de datos desde estaciones meteorológicas remotas

    OpenAIRE

    Rosiek, S.; Batlles, F. J.

    2006-01-01

    Ponencia presentada en: XXIX Jornadas Científicas de la AME y el VII Encuentro Hispano Luso de Meteorología celebrado en Pamplona, del 24 al 26 de abril de 2006. En este trabajo se describen las diferentes metodologías existentes de transmisión de datos desde estaciones meteorológicas remotas. La información a transmitir consiste en datos de temperatura del aire, humedad relativa, radiación global y fotosintéticamente activa (PAR). Los datos experimentales se registran en estaciones loc...

  9. El arte por el arte : aproximación teórico-práctica sobre los beneficios que supone una educación bilingüe curricularmente integrada, utilizando el arte como elemento conductor del proceso de enseñanza-aprendizaje

    OpenAIRE

    Gallego González, Agustín

    2014-01-01

    Trabajo Fin de Grado-Universidad de Salamanca, 2014 [ES] El reto propuesto en el presente trabajo, muestra una visión alternativa, utilizando el arte como elemento conductor a la hora de presentar la educación reglada en un entorno de aprendizaje CLIL. En los tres primeros capítulos, el autor expone y justifica las ventajas de la enseñanza CLIL así como los diferentes aspectos de su metodología activa. A partir del cuarto capítulo, se plantea un proyecto a través de la Unidad Didáctica Van...

  10. USANDO LA WEB 2.0 PARA INFORMARSE E INFORMAR. UNA EXPERIENCIA EN EDUCACIÓN SUPERIOR

    OpenAIRE

    Francisco Amat, Andrea

    2011-01-01

    En un contexto donde la información se ha convertido en la principal material prima y las pantallas inundan el espacio público y privado, las instituciones educativas han de proporcionar herramientas para la comprensión del mundo en el que se vive, la promoción del pensamiento crítico o la construcción de una ciudadanía activa y responsable. En este sentido, la lectura crítica de los mass media y la producción de mensajes mediáticos por parte del estudiantado se torna fundamental. Para el...

  11. LAS MATEMÁTICAS Y EL ARTE: propuesta de intervención en Educación Infantil.

    OpenAIRE

    Bejarano-García, María

    2015-01-01

    Las matemáticas escolares, en muchas ocasiones, resultan alejadas de la realidad y sin aparente aplicabilidad en la vida cotidiana. Partiendo de la idea de que el aprendizaje de las matemáticas está cargado de connotaciones negativas, el trabajo que se presenta ha sido diseñado desde el convencimiento de que hay otra forma de aprender matemáticas mucho más activa, lúdica y natural, haciendo de ellas una herramienta funcional para el conocimiento del entorno que rodea al niño. Para ello, se ha...

  12. Ni princesas ni guerreras, compañeras e iguales en la animación española. La alfabetización como fórmula para alcanzar la equidad de género y la educación en valores a través de los medios de comunicación

    OpenAIRE

    Paredes Fernández, Eugenia

    2012-01-01

    Actualmente, los medios de comunicación se han convertido en protagonistas de interesantes estudios académicos en los que se refuerza la idea, poco a poco admitida, de su papel como elementos capaces de configurar mentalidades y ofrecer modelos de actuación positiva, generando valores sociales entre los receptores más jóvenes. Una de las líneas de estudio más activa es la que propone, a través de fórmulas didácticas a implantar en los colegios, la igualdad y equidad de género utilizando como ...

  13. Desorientación y cirrosis. No siempre encefalopatía hepática

    OpenAIRE

    Sergio Vázquez Rodríguez; Verónica Lázaro González

    2012-01-01

    Mujer de 49 años de edad, con antecedente de hepatopatía crónica de origen alcohólico e ingreso reciente en nuestro servicio por cuadro clínico compatible con hepatitis alcohólica aguda con criterios de gravedad según índice de Maddrey. Una vez descartada infección concomitante, insuficiencia renal y hemorragia digestiva activa, se inició tratamiento con corticoides a dosis habituales, manteniendo posteriormente dicho tratamiento por mejoría analítica según criterios de Lille.

  14. Evaluación del potencial de los humedales construidos como estrategia para la eliminación de productos farmacéuticos y de cuidado personal presentes en aguas residuales domésticas

    OpenAIRE

    Arredondo González, John Alexander

    2016-01-01

    Los productos farmacéuticos y de cuidado personal (PFCP) son sustancias biológicamente activas y persistentes en el ambiente, los cuales hacen parte de un grupo de sustancias conocidas como contaminantes emergentes, que son definidos de esta forma por la poca o nula regulación que tienen en la actualidad y además porque se tiene un alto grado de incertidumbre respecto a los posibles impactos en humanos y ecosistemas acuáticos y terrestres: El objetivo principal de esta investigación fue evalu...

  15. Desorientación y cirrosis. No siempre encefalopatía hepática

    Directory of Open Access Journals (Sweden)

    Sergio Vázquez Rodríguez

    2012-09-01

    Full Text Available Mujer de 49 años de edad, con antecedente de hepatopatía crónica de origen alcohólico e ingreso reciente en nuestro servicio por cuadro clínico compatible con hepatitis alcohólica aguda con criterios de gravedad según índice de Maddrey. Una vez descartada infección concomitante, insuficiencia renal y hemorragia digestiva activa, se inició tratamiento con corticoides a dosis habituales, manteniendo posteriormente dicho tratamiento por mejoría analítica según criterios de Lille.

  16. Integración de mecanismos de control redox y de señalización de nutrientes en la longevidad cronológica de levaduras vínicas

    OpenAIRE

    Picazo Campos, Cecilia

    2017-01-01

    La fase estacionaria es una fase de no división en la cual las células sobreviven a través de la utilización de las reservas almacenadas y mediante la activación de mecanismos de supervivencia. Esta fase estacionaria es la mayor parte del tiempo del proceso fermentativo en el cual las células están metabólicamente activas. La capacidad que tienen las células de sobrevivir en estas condiciones de no división a lo largo del tiempo se denomina Longevidad Cronológica (LC). En la presente tesis...

  17. Un proyecto tutorado interdisciplinar en la formación de maestros. Resultados del proceso de evaluación formativa

    OpenAIRE

    Vallés Rapp, C.

    2009-01-01

    En este documento presentamos el trabajo realizado en el curso actual con futuros maestros de Educación Primaria a través de una metodología activa, como son los proyectos tutorados. La experiencia docente aborda contenidos propios de la anatomía y fisiología del aparato digestivo en la asignatura Biología del Cuerpo Humano, así como las implicaciones en el aula de Educación Primaria como contenidos propios de la asignatura Ciencias Experimentales y su Didáctica. En la presente comunicación s...

  18. Directory of Open Access Journals (Sweden)

    Aliagas, C.

    2009-11-01

    Full Text Available Exploramos con un estudio de caso la lectura comopráctica social en la vida de un adolescente queacaba de abandonar los estudios en 1º de Bachillerato.Desde el prisma teórico de los Nuevos Estudiosde Literacidad, analizamos su punto de vista y suscreencias sobre las prácticas lectoras dominantes yvernáculas en las que participa, dentro y fuera delInstituto. A pesar de su fuerte desinterés por la lecturaacadémica, nuestro informante ha construidouna vida lectora variada y activa al margen de laescuela.

  19. "Aunque lea poco, yo sé que soy listo". Estudio de caso sobre un adolescente que no lee literatura

    Directory of Open Access Journals (Sweden)

    Cristina Aliagas

    2009-01-01

    Full Text Available Exploramos con un estudio de caso la lectura como práctica social en la vida de un adolescente que acaba de abandonar los estudios en 1º de Bachillerato. Desde el prisma teórico de los Nuevos Estudios de Literacidad, analizamos su punto de vista y sus creencias sobre las prácticas lectoras dominantes y vernáculas en las que participa, dentro y fuera del Instituto. A pesar de su fuerte desinterés por la lectura académica, nuestro informante ha construido una vida lectora variada y activa al margen de la escuela.

  20. ¿Paradoja matemática?

    OpenAIRE

    Puchalt, Lucía

    2001-01-01

    Tal vez sea una paradoja o tal vez no, pero los alumnos disfrutaron de la actividad tanto por activa como por pasiva. Aprendieron, repasaron, bailaron y cantaron matemáticas. ¿Cómo que cantaron? ¿Se pueden cantar las matemáticas? Pero, ¿ESO de cantar no se hace en la clase de música?, ¿cómo que cantar en matemáticas? no, no. No es cantar en matemáticas, es cantar las matemáticas.