WorldWideScience

Sample records for processing darpa a-to-i

  1. Doing Business with DARPA

    Science.gov (United States)

    2009-03-01

    Approved For Public Release, Distribution Unlimited 1 Doing Business with DARPA Michael Blackstone Contracting Officer DARPA Contracts Management...DATE MAR 2009 2. REPORT TYPE 3. DATES COVERED 00-00-2009 to 00-00-2009 4. TITLE AND SUBTITLE Doing Business with DARPA 5a. CONTRACT NUMBER...Topics: Business Process (Contracting Perspective) Pre-solicitation Solicitation Evaluation/Selection Negotiations Communications Approved For Public

  2. Innovation at DARPA

    Science.gov (United States)

    2016-07-01

    Distribution Statement A: Approved for Public Release, Distribution Unlimited Innovation at DARPA July 2016 1 Distribution...Statement A: Approved for Public Release, Distribution Unlimited Innovation at DARPA A Long History of Innovation DARPA, the Defense Advanced Research...guided work that has “changed the world"—a phrase frequently heard at DARPA to ensure a focus on transformative innovation as opposed to incremental

  3. Phase I Report: DARPA Exoskeleton Program

    Energy Technology Data Exchange (ETDEWEB)

    Jansen, J.F.

    2004-01-21

    The Defense Advanced Research Projects Agency (DARPA) inaugurated a program addressing research and development for an Exoskeleton for Human Performance Augmentation in FY!2001. A team consisting of Oak Ridge National Laboratory, the prime contractor, AeroVironment, Inc., the Army Research Laboratory, the University of Minnesota, and the Virginia Polytechnic Institute has recently completed an 18-month Phase I effort in support of this DARPA program. The Phase I effort focused on the development and proof-of-concept demonstrations for key enabling technologies, laying the foundation for subsequently building and demonstrating a prototype exoskeleton. The overall approach was driven by the need to optimize energy efficiency while providing a system that augmented the operator in as transparent manner as possible (non-impeding). These needs led to the evolution of two key distinguishing features of this team's approach. The first is the ''no knee contact'' concept. This concept is dependent on a unique Cartesian-based control scheme that uses force sensing at the foot and backpack attachments to allow the exoskeleton to closely follow the operator while avoiding the difficulty of connecting and sensing position at the knee. The second is an emphasis on energy efficiency manifested by an energetic, power, actuation and controls approach designed to enhance energy efficiency as well as a reconfigurable kinematic structure that provides a non-anthropomorphic configuration to support an energy saving long-range march/transport mode. The enabling technologies addressed in the first phase were controls and sensing, the soft tissue interface between the machine and the operator, the power system, and actuation. The controller approach was implemented and demonstrated on a test stand with an actual operator. Control stability, low operator fatigue, force amplification and the human interface were all successfully demonstrated, validating the controls

  4. Overview of implementation of DARPA GPU program in SAIC

    Science.gov (United States)

    Braunreiter, Dennis; Furtek, Jeremy; Chen, Hai-Wen; Healy, Dennis

    2008-04-01

    This paper reviews the implementation of DARPA MTO STAP-BOY program for both Phase I and II conducted at Science Applications International Corporation (SAIC). The STAP-BOY program conducts fast covariance factorization and tuning techniques for space-time adaptive process (STAP) Algorithm Implementation on Graphics Processor unit (GPU) Architectures for Embedded Systems. The first part of our presentation on the DARPA STAP-BOY program will focus on GPU implementation and algorithm innovations for a prototype radar STAP algorithm. The STAP algorithm will be implemented on the GPU, using stream programming (from companies such as PeakStream, ATI Technologies' CTM, and NVIDIA) and traditional graphics APIs. This algorithm will include fast range adaptive STAP weight updates and beamforming applications, each of which has been modified to exploit the parallel nature of graphics architectures.

  5. 77 FR 44063 - Federal Acquisition Regulations; DARPA-New Mexico Tax Agreement

    Science.gov (United States)

    2012-07-26

    ... Federal Acquisition Regulation (FAR) to add the United States Defense Advanced Research Projects Agency... Mexico (NM). The DARPA-NM tax agreement eliminates the double taxation of Government cost-reimbursement... 2012- 019. SUPPLEMENTARY INFORMATION: I. Background On August 18, 2011, DARPA and the Taxation and...

  6. The DARPA manufacturing initiative in high temperature superconductivity

    International Nuclear Information System (INIS)

    Adams, K.R.

    1989-01-01

    The Defense Advanced Research Projects Agency (DARPA) has a very aggressive Technology Base program in high temperature superconductivity. This program is expected to provide the basis for a specialized set of military products - passive microwave and millimeter wave devices - within the next three years. In order to get these high leverage products into military systems, a manufacturing base must be developed for HTSC components. A plan for DARPA in HTSC manufacturing is directly coupled with the ongoing DARPA materials and device oriented R and D program. In essence, this plan recommends a three phased effort: 1. Phase I (two years); Fund companies through R and D contracts for specialized HTSC components; prepare a detailed plan and develop an HTSC consortium. 2. Phase II (six years): Establish an HTSC Sematech initiative for electronic applications, including active devices. 3. Phase III (optional): Continue the HTSC Sematech with emphasis on high power applications

  7. Handbook of natural language processing and machine translation DARPA global autonomous language exploitation

    CERN Document Server

    Olive, Joseph P; McCary, John

    2011-01-01

    This comprehensive handbook, written by leading experts in the field, details the groundbreaking research conducted under the breakthrough GALE program - The Global Autonomous Language Exploitation within the Defense Advanced Research Projects Agency (DARPA), while placing it in the context of previous research in the fields of natural language and signal processing, artificial intelligence and machine translation. The most fundamental contrast between GALE and its predecessor programs was its holistic integration of previously separate or sequential processes. In earlier language research pro

  8. A synopsis of the Defense Advanced Research Projects Agency (DARPA) investment in additive manufacture and what challenges remain

    Science.gov (United States)

    Maher, Michael; Smith, Adrien; Margiotta, Jesse

    2014-03-01

    DARPA's interest in additive manufacture dates back to the mid-80s with seedling programs that developed the foundational knowledge and equipment that led to the Solid Freeform Fabrication program in 1990. The drivers for this program included reducing development times by enabling "tool-less" manufacturing as well as integration of design and fabrication tools. DARPA consistently pushed the boundaries of additive manufacture with follow-on programs that expanded the material suite available for 3-D printing as well as new processes that expanded the technology's capability base. Programs such as the Mesoscopic Integrated Conformal Electronics (MICE) program incorporated functionality to the manufacturing processes through direct write of electronics. DARPA's investment in additive manufacture continues to this day but the focus has changed. DARPA's early investments were focused on developing and demonstrating the technology's capabilities. Now that the technology has been demonstrated, there is serious interest in taking advantage of the attributes unique to the processing methodology (such as customization and new design possibilities) for producing production parts. Accordingly, today's investment at DARPA addresses the systematic barriers to implementation rather than the technology itself. The Open Manufacturing program is enabling rapid qualification of new technologies for the manufacturing environment through the development of new modeling and informatics tools. While the technology is becoming more mainstream, there are plenty of challenges that need to be addressed. And as the technology continues to mature, the agency will continue to look for those "DARPA-hard" challenges that enable revolutionary changes in capability and performance for the Department of Defense.

  9. Steady and Unsteady Force and Moment Data on a DARPA2 Submarine

    OpenAIRE

    Whitfield, Cindy Carol

    1999-01-01

    Steady and unsteady force and moment experiments were conducted in the Virginia Tech Stability wind tunnel using the Dynamic Plunge-Pitch-Roll (DyPPiR) model mount to perform rapid time-dependent,high-excursion maneuvers. The experiments were performed for a DARPA2 submarine model using three widely spaced 2-force-component loadcells and three tri-axial accelerometers to extract the aerodynamic loads. The DARPA2 model was tested with different body configurations in two different test sect...

  10. An overview of DARPA's advanced space technology program

    Science.gov (United States)

    Nicastri, E.; Dodd, J.

    1993-02-01

    The Defense Advanced Research Projects Agency (DARPA) is the central research and development organization of the DoD and, as such, has the primary responsibility for the maintenance of U.S. technological superiority over potential adversaries. DARPA's programs focus on technology development and proof-of-concept demonstrations of both evolutionary and revolutionary approaches for improved strategic, conventional, rapid deployment and sea power forces, and on the scientific investigation into advanced basic technologies of the future. DARPA can move quickly to exploit new ideas and concepts by working directly with industry and universities. For four years, DARPA's Advanced Space Technology Program (ASTP) has addressed various ways to improve the performance of small satellites and launch vehicles. The advanced technologies that are being and will be developed by DARPA for small satellites can be used just as easily on large satellites. The primary objective of the ASTP is to enhance support to operational commanders by developing and applying advanced technologies that will provide cost-effective, timely, flexible, and responsive space systems. Fundamental to the ASTP effort is finding new ways to do business with the goal of quickly inserting new technologies into DoD space systems while reducing cost. In our view, these methods are prime examples of what may be termed 'technology leveraging.' The ASTP has initiated over 50 technology projects, many of which were completed and transitioned to users. The objectives are to quickly qualify these higher risk technologies for use on future programs and reduce the risk of inserting these technologies into major systems, and to provide the miniaturized systems that would enable smaller satellites to have significant - rather than limited - capability. Only a few of the advanced technologies are described, the majority of which are applicable to both large and small satellites.

  11. DARPA-funded efforts in the development of novel brain-computer interface technologies.

    Science.gov (United States)

    Miranda, Robbin A; Casebeer, William D; Hein, Amy M; Judy, Jack W; Krotkov, Eric P; Laabs, Tracy L; Manzo, Justin E; Pankratz, Kent G; Pratt, Gill A; Sanchez, Justin C; Weber, Douglas J; Wheeler, Tracey L; Ling, Geoffrey S F

    2015-04-15

    The Defense Advanced Research Projects Agency (DARPA) has funded innovative scientific research and technology developments in the field of brain-computer interfaces (BCI) since the 1970s. This review highlights some of DARPA's major advances in the field of BCI, particularly those made in recent years. Two broad categories of DARPA programs are presented with respect to the ultimate goals of supporting the nation's warfighters: (1) BCI efforts aimed at restoring neural and/or behavioral function, and (2) BCI efforts aimed at improving human training and performance. The programs discussed are synergistic and complementary to one another, and, moreover, promote interdisciplinary collaborations among researchers, engineers, and clinicians. Finally, this review includes a summary of some of the remaining challenges for the field of BCI, as well as the goals of new DARPA efforts in this domain. Copyright © 2014 The Authors. Published by Elsevier B.V. All rights reserved.

  12. 77 FR 66823 - Freedom of Information Act Request for Papers Submitted to DARPA for the 2011 100 Year Starship...

    Science.gov (United States)

    2012-11-07

    ... DEPARTMENT OF DEFENSE Office of the Secretary Freedom of Information Act Request for Papers... by DARPA under the Freedom of Information Act. DATES: All written correspondence must be received by DARPA by close of business December 7, 2012. ADDRESSES: Send written comments concerning this Freedom of...

  13. The DARPA quantum network

    International Nuclear Information System (INIS)

    Elliot, B.

    2005-01-01

    Full text: The DARPA quantum network is now in initial operational, with six nodes performing quantum cryptography 24x7 across the Boston metro area between our campuses at Harvard University, Boston University, and BBN Technologies. In this talk, we present our recent activities, including the deployment of this network, building our Mark 1 Entangled QKD system, porting BBN QKD protocol software to NIST and Qinetiq freespace systems, performing initial design of a superconducting single photon detector with U. Rochester and NIST Boulder, and implementing a novel Low-Density Parity Check (LDPC) protocol for QKD. (author)

  14. Exploration of Digital Circuits and Transistor-Level Testing in the DARPA TRUST Program

    Science.gov (United States)

    2015-03-01

    attacked is to have the Trojan Horse being the signal. The term Trojan Horse was originally invented when the Greek soldiers tried to invade Troy but...night Greek soldiers came out of the horse and destroyed the city. Nowadays, a Trojan Horse is a seemingly innocuous piece of hardware or software...the DARPA TRUST program was initiated and continues to be a vital component in the war fighting effort of the DoD. One reason that the DARPA TRUST

  15. Virginia Tech team qualifies as DARPA Urban Challenge semi-finalist

    OpenAIRE

    Crumbley, Liz

    2007-01-01

    "VictorTango," a team of Virginia Tech engineering and geography students, will travel to Victorville, Calif., for the national qualifying rounds of the Urban Challenge autonomous vehicle competition, sponsored by the Defense Advanced Research Projects Agency (DARPA).

  16. Developing a Speaker Identification System for the DARPA RATS Project

    DEFF Research Database (Denmark)

    Plchot, O; Matsoukas, S; Matejka, P

    2013-01-01

    This paper describes the speaker identification (SID) system developed by the Patrol team for the first phase of the DARPA RATS (Robust Automatic Transcription of Speech) program, which seeks to advance state of the art detection capabilities on audio from highly degraded communication channels. ...... such as CFCCs out-perform MFCC front-ends on noisy audio, and (c) fusion of multiple systems provides 24% relative improvement in EER compared to the single best system when using a novel SVM-based fusion algorithm that uses side information such as gender, language, and channel id....

  17. Semantic Web Services with Web Ontology Language (OWL-S) - Specification of Agent-Services for DARPA Agent Markup Language (DAML)

    National Research Council Canada - National Science Library

    Sycara, Katia P

    2006-01-01

    CMU did research and development on semantic web services using OWL-S, the semantic web service language under the Defense Advanced Research Projects Agency- DARPA Agent Markup Language (DARPA-DAML) program...

  18. Personal radiation detector at a high technology readiness level that satisfies DARPA's SN-13-47 and SIGMA program requirements

    Science.gov (United States)

    Ginzburg, D.; Knafo, Y.; Manor, A.; Seif, R.; Ghelman, M.; Ellenbogen, M.; Pushkarsky, V.; Ifergan, Y.; Semyonov, N.; Wengrowicz, U.; Mazor, T.; Kadmon, Y.; Cohen, Y.; Osovizky, A.

    2015-06-01

    There is a need to develop new personal radiation detector (PRD) technologies that can be mass produced. On August 2013, DARPA released a request for information (RFI) seeking innovative radiation detection technologies. In addition, on December 2013, a Broad Agency Announcement (BAA) for the SIGMA program was released. The RFI requirements focused on a sensor that should possess three main properties: low cost, high compactness and radioisotope identification capabilities. The identification performances should facilitate the detection of a hidden threat, ranging from special nuclear materials (SNM) to commonly used radiological sources. Subsequently, the BAA presented the specific requirements at an instrument level and provided a comparison between the current market status (state-of-the-art) and the SIGMA program objectives. This work presents an optional alternative for both the detection technology (sensor with communication output and without user interface) for DARPA's initial RFI and for the PRD required by the SIGMA program. A broad discussion is dedicated to the method proposed to fulfill the program objectives and to the selected alternative that is based on the PDS-GO design and technology. The PDS-GO is the first commercially available PRD that is based on a scintillation crystal optically coupled with a silicon photomultiplier (SiPM), a solid-state light sensor. This work presents the current performance of the instrument and possible future upgrades based on recent technological improvements in the SiPM design. The approach of utilizing the SiPM with a commonly available CsI(Tl) crystal is the key for achieving the program objectives. This approach provides the appropriate performance, low cost, mass production and small dimensions; however, it requires a creative approach to overcome the obstacles of the solid-state detector dark current (noise) and gain stabilization over a wide temperature range. Based on the presented results, we presume that

  19. DARPA Antibody Technology Program. Standardized Test Bed for Antibody Characterization: Characterization of an MS2 ScFv Antibody Produced by Illumina

    Science.gov (United States)

    2016-08-01

    ECBC-TR-1395 DARPA ANTIBODY TECHNOLOGY PROGRAM STANDARDIZED TEST BED FOR... ANTIBODY CHARACTERIZATION: CHARACTERIZATION OF AN MS2 SCFV ANTIBODY PRODUCED BY ILLUMINA Patricia E. Buckley Alena M. Calm Heather Welsh Roy...4. TITLE AND SUBTITLE DARPA Antibody Technology Program Standardized Test Bed for Antibody Characterization: Characterization of an MS2 ScFv

  20. Tactile Gloves for Autonomous Grasping With the NASA/DARPA Robonaut

    Science.gov (United States)

    Martin, T. B.; Ambrose, R. O.; Diftler, M. A.; Platt, R., Jr.; Butzer, M. J.

    2004-01-01

    Tactile data from rugged gloves are providing the foundation for developing autonomous grasping skills for the NASA/DARPA Robonaut, a dexterous humanoid robot. These custom gloves compliment the human like dexterity available in the Robonaut hands. Multiple versions of the gloves are discussed, showing a progression in using advanced materials and construction techniques to enhance sensitivity and overall sensor coverage. The force data provided by the gloves can be used to improve dexterous, tool and power grasping primitives. Experiments with the latest gloves focus on the use of tools, specifically a power drill used to approximate an astronaut's torque tool.

  1. Modeling Temporal Processes in Early Spacecraft Design: Application of Discrete-Event Simulations for Darpa's F6 Program

    Science.gov (United States)

    Dubos, Gregory F.; Cornford, Steven

    2012-01-01

    While the ability to model the state of a space system over time is essential during spacecraft operations, the use of time-based simulations remains rare in preliminary design. The absence of the time dimension in most traditional early design tools can however become a hurdle when designing complex systems whose development and operations can be disrupted by various events, such as delays or failures. As the value delivered by a space system is highly affected by such events, exploring the trade space for designs that yield the maximum value calls for the explicit modeling of time.This paper discusses the use of discrete-event models to simulate spacecraft development schedule as well as operational scenarios and on-orbit resources in the presence of uncertainty. It illustrates how such simulations can be utilized to support trade studies, through the example of a tool developed for DARPA's F6 program to assist the design of "fractionated spacecraft".

  2. IHMC's experience competing in the Cybathlon compared to the DARPA robotics challenge.

    Science.gov (United States)

    Neuhaus, Peter

    2017-11-09

    As a research scientist, my work tends to focus on scientific investigations. Our group occasionally makes discoveries or has a successful demonstration, and sometimes we can even repeatedly demonstrate something working on the hardware. This mode of operation works for research, but not for competitions. In the past few years, I have participated in two international robotics competitions, the DARPA Robotics Challenge (DRC) and the Cybathlon; the research and development process for these competitions is significantly different from our typical research work. This commentary discusses our experience preparing for the Cybathlon, and contrasts it with our experience with the DRC. The human in the loop for the Cybathlon was the biggest differentiator between the DRC and the Cybathlon. Having the human at the center of the competition not only changed the way we developed, but changed how we viewed the impact of our work. For the DRC, a physics based dynamic simulation was a powerful, and invaluable, tool for not only the algorithm developers, but the robot operator as well. For the Cybathlon, simulation was of little use because the all of closed-loop control was performed by the pilot. In the software development cycle for the Cybathlon, the push was to just come up with something that works and "lock it down" and do not change it, so that the pilot could train with a given set of motions that would not change and make up for any deficiencies with his own abilities. The Cybathlon was more of an athletic challenge for the human who was assisted by technology. The DRC was the opposite, it was a robotics challenge assisted by a human. This commentary focuses on describing the Florida Institute for Human and Machine Cognition's (IHMC) experience leading up to and at the Cybathlon, with some comparisons to the DRC experience. The Cybathlon was a very worthwhile experience me, my team, and of course our pilot. Knowing that our development could improve the quality of life

  3. A Summary of the Rendezvous, Proximity Operations, Docking, and Undocking (RPODU) Lessons Learned from the Defense Advanced Research Project Agency (DARPA) Orbital Express (OE) Demonstration System Mission

    Science.gov (United States)

    Dennehy, Cornelius J.; Carpenter, James R.

    2011-01-01

    The Guidance, Navigation, and Control (GN&C) Technical Discipline Team (TDT) sponsored Dr. J. Russell Carpenter, a Navigation and Rendezvous Subject Matter Expert (SME) from NASA's Goddard Space Flight Center (GSFC), to provide support to the Defense Advanced Research Project Agency (DARPA) Orbital Express (OE) rendezvous and docking flight test that was conducted in 2007. When that DARPA OE mission was completed, Mr. Neil Dennehy, NASA Technical Fellow for GN&C, requested Dr. Carpenter document his findings (lessons learned) and recommendations for future rendezvous missions resulting from his OE support experience. This report captures lessons specifically from anomalies that occurred during one of OE's unmated operations.

  4. Evaluation of the Intel iWarp parallel processor for space flight applications

    Science.gov (United States)

    Hine, Butler P., III; Fong, Terrence W.

    1993-01-01

    The potential of a DARPA-sponsored advanced processor, the Intel iWarp, for use in future SSF Data Management Systems (DMS) upgrades is evaluated through integration into the Ames DMS testbed and applications testing. The iWarp is a distributed, parallel computing system well suited for high performance computing applications such as matrix operations and image processing. The system architecture is modular, supports systolic and message-based computation, and is capable of providing massive computational power in a low-cost, low-power package. As a consequence, the iWarp offers significant potential for advanced space-based computing. This research seeks to determine the iWarp's suitability as a processing device for space missions. In particular, the project focuses on evaluating the ease of integrating the iWarp into the SSF DMS baseline architecture and the iWarp's ability to support computationally stressing applications representative of SSF tasks.

  5. Search of the Deep and Dark Web via DARPA Memex

    Science.gov (United States)

    Mattmann, C. A.

    2015-12-01

    Search has progressed through several stages due to the increasing size of the Web. Search engines first focused on text and its rate of occurrence; then focused on the notion of link analysis and citation then on interactivity and guided search; and now on the use of social media - who we interact with, what we comment on, and who we follow (and who follows us). The next stage, referred to as "deep search," requires solutions that can bring together text, images, video, importance, interactivity, and social media to solve this challenging problem. The Apache Nutch project provides an open framework for large-scale, targeted, vertical search with capabilities to support all past and potential future search engine foci. Nutch is a flexible infrastructure allowing open access to ranking; URL selection and filtering approaches, to the link graph generated from search, and Nutch has spawned entire sub communities including Apache Hadoop and Apache Tika. It addresses many current needs with the capability to support new technologies such as image and video. On the DARPA Memex project, we are creating create specific extensions to Nutch that will directly improve its overall technological superiority for search and that will directly allow us to address complex search problems including human trafficking. We are integrating state-of-the-art algorithms developed by Kitware for IARPA Aladdin combined with work by Harvard to provide image and video understanding support allowing automatic detection of people and things and massive deployment via Nutch. We are expanding Apache Tika for scene understanding, object/person detection and classification in images/video. We are delivering an interactive and visual interface for initiating Nutch crawls. The interface uses Python technologies to expose Nutch data and to provide a domain specific language for crawls. With the Bokeh visualization library the interface we are delivering simple interactive crawl visualization and

  6. The DARPA compact Superconducting X-Ray Lithography Source features

    International Nuclear Information System (INIS)

    Heese, R.; Kalsi, S.; Leung, E.

    1991-01-01

    Under DARPA sponsorship, a compact Superconducting X-Ray Lithography Source (SXLS) is being designed and built by the Brookhaven National Laboratory (BNL) with industry participation from Grumman Corporation and General Dynamics. This source is optimized for lithography work for sub-micron high density computer chips, and is about the size of a billiard table (1.5 m x 4.0 m). The machine has a racetrack configuration with two 180 degree bending magnets being designed and built by General Dynamics under a subcontract with Grumman Corporation. The machine will have 18 photon ports which would deliver light peaked at a wave length of 10 Angstroms. Grumman is commercializing the SXLS device and plans to book orders for delivery of industrialized SXLS (ISXLS) versions in 1995. This paper will describe the major features of this device. The commercial machine will be equipped with a fully automated user-friendly control systems, major features of which are already working on a compact warm dipole ring at BNL. This ring has normal dipole magnets with dimensions identical to the SXLS device, and has been successfully commissioned

  7. A Transcription Scheme for Languages Employing the Arabic Script Motivated by Speech Processing Application

    National Research Council Canada - National Science Library

    Ganjavi, Shadi; Georgiou, Panayiotis G; Narayanan, Shrikanth

    2004-01-01

    ... (The DARPA Babylon Program; Narayanan, 2003). In this paper, we discuss transcription systems needed for automated spoken language processing applications in Persian that uses the Arabic script for writing...

  8. Defense Small Business Innovation Research Program (SBIR). Abstracts of Phase I Awards. 1986.

    Science.gov (United States)

    1986-01-01

    CLINICS TO DETECT HUMAN LEPTOSPIROSIS AND BY VETERINARIANS IN THE FIELD FOR DIAGNOSIS OF THIS DISEASE IN LIVESTOCK. " CRAIG DEVELOPMENT CORP DARPA...50,000 7767 E QUAKER RD ORCHARD PARK, NY 14127 * DWIGHT R CRAIG *TITLE: SMALL HIGH POWER HIGH ENERGY DENSITY BATTERIES T 9 OFFICE: DARPA THE MILITARY...FISCAL YEAR 1986 AWARDED SUBMITTED BY DEPT AMOUNT ] DEEGAN RESEARCH GP INC NAVY $ 49,162," 728 BRISTOL FERRY RD PORTSMOUTH, RI 02871 T DEEGAN TITLE

  9. Vision-Based Navigation for Formation Flight onboard ISS, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — The RINGS project (Resonant Inductive Near-field Generation Systems) was a DARPA-funded effort to demonstrate Electromagnetic Formation Flight and wireless power...

  10. A Workshop for Planning the Efficient Transfer of Recent Ceramic Armor/Antiarmor Modeling Results to the Armor Design Community: Summary and Draft Plan

    National Research Council Canada - National Science Library

    Klopp, Richard

    1999-01-01

    In the mid-1980s DARPA began sponsoring several programs to develop ceramic armor for heavy armor applications, supported by DARPA and ARO funded technology base initiatives in modeling, experiments...

  11. Development of procedure using plasma welding process to produce 125I seeds

    International Nuclear Information System (INIS)

    Feher, Anselmo

    2006-01-01

    The prostate cancer, which is the second cause of death by cancer in men, overcome only by lung cancer, is a problem of public health in Brazil. Brachytherapy is among the possible available treatments for prostate cancer, in which small seeds containing 125 I radioisotope are implanted in the prostate. The seed consists of a titanium sealed capsule with 0.8 mm external diameter and 4.5 mm length, containing a central silver wire with adsorbed 125 I. The plasma arc welding is one of the viable techniques for the sealing process. The equipment used in this technique is less costly than in other processes. The main objective of this work was the development and the validation of the welding procedure using plasma welding process and the elaboration of a sealing routine according to Good Manufacturing Practices. The development of this work has presented the following phases: cut and cleaning of the titanium material, determination of the welding parameters, development of a device for holding the titanium tube during the welding process, validation of sealed sources according to ISO 2919 Sealed Radioactive Sources - General Requirements and Classification, leakage test according to ISO 9978 Sealed Radioactive Sources - Leakage Test Methods and metallographic assays. The developed procedure, to seal 125 I seeds using plasma welding process, has shown to be efficient, satisfying all the established requirements of ISO 2919. The results obtained in this work have given the possibility to establish a routine production process according to the orientations presented in resolution RDC number 59 - Good Manufacturing Practices do Medical Products of the ANVISA - Brazilian Nacional Agency of Sanitary Surveillance. (author)

  12. CIPSS [computer-integrated process and safeguards system]: The integration of computer-integrated manufacturing and robotics with safeguards, security, and process operations

    International Nuclear Information System (INIS)

    Leonard, R.S.; Evans, J.C.

    1987-01-01

    This poster session describes the computer-integrated process and safeguards system (CIPSS). The CIPSS combines systems developed for factory automation and automated mechanical functions (robots) with varying degrees of intelligence (expert systems) to create an integrated system that would satisfy current and emerging security and safeguards requirements. Specifically, CIPSS is an extension of the automated physical security functions concepts. The CIPSS also incorporates the concepts of computer-integrated manufacturing (CIM) with integrated safeguards concepts, and draws upon the Defense Advance Research Project Agency's (DARPA's) strategic computing program

  13. X-Ray Pulsar Based Navigation and Time Determination, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — DARPA recently initiated the XNAV program to undertake development of GPS independent, precision navigation and time determination based on observations of certain...

  14. Thin-Film Transformation of NH4 PbI3 to CH3 NH3 PbI3 Perovskite: A Methylamine-Induced Conversion-Healing Process.

    Science.gov (United States)

    Zong, Yingxia; Zhou, Yuanyuan; Ju, Minggang; Garces, Hector F; Krause, Amanda R; Ji, Fuxiang; Cui, Guanglei; Zeng, Xiao Cheng; Padture, Nitin P; Pang, Shuping

    2016-11-14

    Methylamine-induced thin-film transformation at room-temperature is discovered, where a porous, rough, polycrystalline NH 4 PbI 3 non-perovskite thin film converts stepwise into a dense, ultrasmooth, textured CH 3 NH 3 PbI 3 perovskite thin film. Owing to the beneficial phase/structural development of the thin film, its photovoltaic properties undergo dramatic enhancement during this NH 4 PbI 3 -to-CH 3 NH 3 PbI 3 transformation process. The chemical origins of this transformation are studied at various length scales. © 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  15. DARPA ADAMS Project

    Science.gov (United States)

    2015-05-11

    it means that Mary distrusts John. We showed that it is possible to analyze such trust- distrust relationships within signed social networks in... relationship problems) − Professional Problems (negative changes at workplace, interpersonal conflicts) Furthermore, we encode in 2nd degree variables...a social media forum data. • Processed initial set of Vegas metrics data (clustering coefficient, # similar users, # skip levels) through time

  16. 30 CFR 206.181 - How do I establish processing costs for dual accounting purposes when I do not process the gas?

    Science.gov (United States)

    2010-07-01

    ... accounting purposes when I do not process the gas? 206.181 Section 206.181 Mineral Resources MINERALS... Processing Allowances § 206.181 How do I establish processing costs for dual accounting purposes when I do not process the gas? Where accounting for comparison (dual accounting) is required for gas production...

  17. DARPA Technical Accomplishments. An Historical Review of Selected DARPA Projects. Volume 1

    Science.gov (United States)

    1990-02-01

    According to Mr. Albert Rubenstein, ARPA program manager at the time, Bell Telephone Laboratories (BTL), then constructing the Army’s Nike-Zeus Ballistic...18th Tri- Service Radar Symposiun, 1972, Vol. 1, p. 21. 14 Discussion with Mr. Albert Rubenstein, IDA, ARPA Defender Program Manager in 1958-59...in its use in Vietnam. 16-3 X26B-QT-2 INDUSTRY SAILPLANE TECHNOLOGY NAVY TEST PILOT TRNG ARMY SCHWEITZER AGILE VN REQUIREMENT I mmi" -" ~ ~ M . . •1OD

  18. Process Convergence of Self-Normalized Sums of i.i.d. Random ...

    Indian Academy of Sciences (India)

    ... either of tightness or finite dimensional convergence to a non-degenerate limiting distribution does not hold. This work is an extension of the work by Csörgő et al. who showed Donsker's theorem for Y n , 2 ( ⋅ p ) , i.e., for p = 2 , holds i f f =2 and identified the limiting process as a standard Brownian motion in sup norm.

  19. Design process for applying the nonlocal thermal transport iSNB model to a Polar-Drive ICF simulation

    Science.gov (United States)

    Cao, Duc; Moses, Gregory; Delettrez, Jacques; Collins, Timothy

    2014-10-01

    A design process is presented for the nonlocal thermal transport iSNB (implicit Schurtz, Nicolai, and Busquet) model to provide reliable nonlocal thermal transport in polar-drive ICF simulations. Results from the iSNB model are known to be sensitive to changes in the SNB ``mean free path'' formula, and the latter's original form required modification to obtain realistic preheat levels. In the presented design process, SNB mean free paths are first modified until the model can match temperatures from Goncharov's thermal transport model in 1D temperature relaxation simulations. Afterwards the same mean free paths are tested in a 1D polar-drive surrogate simulation to match adiabats from Goncharov's model. After passing the two previous steps, the model can then be run in a full 2D polar-drive simulation. This research is supported by the University of Rochester Laboratory for Laser Energetics.

  20. iMOSFLM: a new graphical interface for diffraction-image processing with MOSFLM

    International Nuclear Information System (INIS)

    Battye, T. Geoff G.; Kontogiannis, Luke; Johnson, Owen; Powell, Harold R.; Leslie, Andrew G. W.

    2011-01-01

    A new graphical user interface to the MOSFLM program has been developed to simplify the processing of macromolecular diffraction data. The interface, iMOSFLM, allows data processing via a series of clearly defined tasks and provides visual feedback on the progress of each stage. iMOSFLM is a graphical user interface to the diffraction data-integration program MOSFLM. It is designed to simplify data processing by dividing the process into a series of steps, which are normally carried out sequentially. Each step has its own display pane, allowing control over parameters that influence that step and providing graphical feedback to the user. Suitable values for integration parameters are set automatically, but additional menus provide a detailed level of control for experienced users. The image display and the interfaces to the different tasks (indexing, strategy calculation, cell refinement, integration and history) are described. The most important parameters for each step and the best way of assessing success or failure are discussed

  1. The Mycobacterium tuberculosis phagosome is a HLA-I processing competent organelle.

    Directory of Open Access Journals (Sweden)

    Jeff E Grotzke

    2009-04-01

    Full Text Available Mycobacterium tuberculosis (Mtb resides in a long-lived phagosomal compartment that resists maturation. The manner by which Mtb antigens are processed and presented on MHC Class I molecules is poorly understood. Using human dendritic cells and IFN-gamma release by CD8(+ T cell clones, we examined the processing and presentation pathway for two Mtb-derived antigens, each presented by a distinct HLA-I allele (HLA-Ia versus HLA-Ib. Presentation of both antigens is blocked by the retrotranslocation inhibitor exotoxin A. Inhibitor studies demonstrate that, after reaching the cytosol, both antigens require proteasomal degradation and TAP transport, but differ in the requirement for ER-golgi egress and new protein synthesis. Specifically, presentation by HLA-B8 but not HLA-E requires newly synthesized HLA-I and transport through the ER-golgi. Phenotypic analysis of the Mtb phagosome by flow organellometry revealed the presence of Class I and loading accessory molecules, including TAP and PDI. Furthermore, loaded HLA-I:peptide complexes are present within the Mtb phagosome, with a pronounced bias towards HLA-E:peptide complexes. In addition, protein analysis also reveals that HLA-E is enriched within the Mtb phagosome compared to HLA-A2. Together, these data suggest that the phagosome, through acquisition of ER-localized machinery and as a site of HLA-I loading, plays a vital role in the presentation of Mtb-derived antigens, similar to that described for presentation of latex bead-associated antigens. This is, to our knowledge, the first description of this presentation pathway for an intracellular pathogen. Moreover, these data suggest that HLA-E may play a unique role in the presentation of phagosomal antigens.

  2. iMagis 2.0: a platform toward image-based processes inherent to radiation therapy

    International Nuclear Information System (INIS)

    Daudinot Lopez, M.; Miller Clemente, R.; Gonce Hernandez, E.

    2015-01-01

    Radiotherapy is one of the main weapons against the leading cause of death in Cuba. The integration between radiotherapy and imaging modalities show an increasing trend across clinical applications, innovation and research. The availability of a platform for the inclusion of new applications in this area is crucial. the goal of this work was to demonstrate the possibilities of iMagis 2.0 as an existing platform, with applications in the planning process of pre-treatment based on images of cancer patients. iMagis® was the first Cuban PACS DICOM support, and the most widely applied in the Cuban Health System. Some available plugins were applied for medical planning of simulated patients with a homemade flatbed prototype, the latter installed on a CT unit SHIMADZU SCT 7800 TC in an Oncology Center. Multiple views for definitions of treatment volume were used, including the two-dimensional multiplanar reconstructions visualization. the viability of basic operations such as zoom images, rotations and translations are demonstrated. Monitoring changes in tumor volume during treatment were shown in combination with the estimated statistics of regions of interest. iMagis® supports a wide range of imaging modalities: computed Tomography, Magnetic Imaging PET / CT scan, Ultrasound, angiography, SPECT and providing a ready platform for adding new feature for radiotherapy and diagnostic. (Author)

  3. Decision-Making Process Related to Participation in Phase I Clinical Trials: A Nonsystematic Review of the Existing Evidence.

    Science.gov (United States)

    Gorini, Alessandra; Mazzocco, Ketti; Pravettoni, Gabriella

    2015-01-01

    Due to the lack of other treatment options, patient candidates for participation in phase I clinical trials are considered the most vulnerable, and many ethical concerns have emerged regarding the informed consent process used in the experimental design of such trials. Starting with these considerations, this nonsystematic review is aimed at analyzing the decision-making processes underlying patients' decision about whether to participate (or not) in phase I trials in order to clarify the cognitive and emotional aspects most strongly implicated in this decision. Considering that there is no uniform decision calculus and that many different variables other than the patient-physician relationship (including demographic, clinical, and personal characteristics) may influence patients' preferences for and processing of information, we conclude that patients' informed decision-making can be facilitated by creating a rigorously developed, calibrated, and validated computer tool modeled on each single patient's knowledge, values, and emotional and cognitive decisional skills. Such a tool will also help oncologists to provide tailored medical information that is useful to improve the shared decision-making process, thereby possibly increasing patient participation in clinical trials. © 2015 S. Karger AG, Basel.

  4. The Quantification Process for the PRiME-U34i

    International Nuclear Information System (INIS)

    Hwang, Mee-Jeong; Han, Sang-Hoon; Yang, Joon-Eon

    2006-01-01

    In this paper, we introduce the quantification process for the PRIME-U34i, which is the merged model of ETs (Event Trees) and FTs (Fault Trees) for the level 1 internal PSA of UCN 3 and 4. PRiME-U34i has one top event. Therefore, the quantification process is changed to a simplified method when compared to the past one. In the past, we used the text file called a user file to control the quantification process. However, this user file is so complicated that it is difficult for a non-expert to understand it. Moreover, in the past PSA, ET and FT were separated but in PRiMEU34i, ET and FT were merged together. Thus, the quantification process is different. This paper is composed of five sections. In section 2, we introduce the construction of the one top model. Section 3 shows the quantification process used in the PRiME-U34i. Section 4 describes the post processing. Last section is the conclusions

  5. Polymorphous Computing Architecture (PCA) Application Benchmark 1: Three-Dimensional Radar Data Processing

    National Research Council Canada - National Science Library

    Lebak, J

    2001-01-01

    The DARPA Polymorphous Computing Architecture (PCA) program is building advanced computer architectures that can reorganize their computation and communication structures to achieve better overall application performance...

  6. DARPA Technical Accomplishments. Volume 2. An Historical Review of Selected DARPA Projects

    Science.gov (United States)

    1991-04-01

    without regard to biological realism ). 6 Image understanding is very different from image processing, which studies image- to-in’age transformation, not...to note that Jacobs and Weltnma.’ brought, respectively, radar and cinematic technology orientations to the work through theit family experiences and...eed for realistic battle-engagement simulation as followE: The next issue is thati-.f putting, as well as one can, wartime realism into simulation

  7. Low-molecular-weight color pI markers to monitor on-line the peptide focusing process in OFFGEL fractionation.

    Science.gov (United States)

    Michelland, Sylvie; Bourgoin-Voillard, Sandrine; Cunin, Valérie; Tollance, Axel; Bertolino, Pascal; Slais, Karel; Seve, Michel

    2017-08-01

    High-throughput mass spectrometry-based proteomic analysis requires peptide fractionation to simplify complex biological samples and increase proteome coverage. OFFGEL fractionation technology became a common method to separate peptides or proteins using isoelectric focusing in an immobilized pH gradient. However, the OFFGEL focusing process may be further optimized and controlled in terms of separation time and pI resolution. Here we evaluated OFFGEL technology to separate peptides from different samples in the presence of low-molecular-weight (LMW) color pI markers to visualize the focusing process. LMW color pI markers covering a large pH range were added to the peptide mixture before OFFGEL fractionation using a 24-wells device encompassing the pH range 3-10. We also explored the impact of LMW color pI markers on peptide fractionation labeled previously for iTRAQ. Then, fractionated peptides were separated by RP_HPLC prior to MS analysis using MALDI-TOF/TOF mass spectrometry in MS and MS/MS modes. Here we report the performance of the peptide focusing process in the presence of LMW color pI markers as on-line trackers during the OFFGEL process and the possibility to use them as pI controls for peptide focusing. This method improves the workflow for peptide fractionation in a bottom-up proteomic approach with or without iTRAQ labeling. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  8. Hybrid perovskite solar cells: In situ investigation of solution-processed PbI2 reveals metastable precursors and a pathway to producing porous thin films

    KAUST Repository

    Barrit, Dounya

    2017-04-17

    The successful and widely used two-step process of producing the hybrid organic-inorganic perovskite CH3NH3PbI3, consists of converting a solution deposited PbI2 film by reacting it with CH3NH3I. Here, we investigate the solidification of PbI2 films from a DMF solution by performing in situ grazing incidence wide angle X-ray scattering (GIWAXS) measurements. The measurements reveal an elaborate sol–gel process involving three PbI2⋅DMF solvate complexes—including disordered and ordered ones—prior to PbI2 formation. The ordered solvates appear to be metastable as they transform into the PbI2 phase in air within minutes without annealing. Morphological analysis of air-dried and annealed films reveals that the air-dried PbI2 is substantially more porous when the coating process produces one of the intermediate solvates, making this more suitable for subsequent conversion into the perovskite phase. The observation of metastable solvates on the pathway to PbI2 formation open up new opportunities for influencing the two-step conversion of metal halides into efficient light harvesting or emitting perovskite semiconductors.

  9. Regulatory factors governing adenosine-to-inosine (A-to-I) RNA editing.

    Science.gov (United States)

    Hong, HuiQi; Lin, Jaymie Siqi; Chen, Leilei

    2015-03-31

    Adenosine-to-inosine (A-to-I) RNA editing, the most prevalent mode of transcript modification in higher eukaryotes, is catalysed by the adenosine deaminases acting on RNA (ADARs). A-to-I editing imposes an additional layer of gene regulation as it dictates various aspects of RNA metabolism, including RNA folding, processing, localization and degradation. Furthermore, editing events in exonic regions contribute to proteome diversity as translational machinery decodes inosine as guanosine. Although it has been demonstrated that dysregulated A-to-I editing contributes to various diseases, the precise regulatory mechanisms governing this critical cellular process have yet to be fully elucidated. However, integration of previous studies revealed that regulation of A-to-I editing is multifaceted, weaving an intricate network of auto- and transregulations, including the involvement of virus-originated factors like adenovirus-associated RNA. Taken together, it is apparent that tipping of any regulatory components will have profound effects on A-to-I editing, which in turn contributes to both normal and aberrant physiological conditions. A complete understanding of this intricate regulatory network may ultimately be translated into new therapeutic strategies against diseases driven by perturbed RNA editing events. Herein, we review the current state of knowledge on the regulatory mechanisms governing A-to-I editing and propose the role of other co-factors that may be involved in this complex regulatory process.

  10. The QUANTUM I project: Parallel processing in a local area network work dedicated to ab initio calculation of potential hypersurfaces

    International Nuclear Information System (INIS)

    Lavenir, E.; Pic, J.M.; Alibran, P.; Leclercq, J.M.

    1987-01-01

    The QUANTUM I project is a three-stage device. The stages are respectively dedicated to particular steps of the ab initio determination of a point on the hypersurface. The first stage deals with the computation of the integrals between the basis functions, the second with the S.C.F. (or M.C.S.C.F.) process and the third with the C.I treatment. Each step is developed in terms of parallel mode (M.I.M.D.), the whole device working following a pipeline mode: the three stages works simultaneously for different points

  11. Effects of Forming Process on Composite mode I Interlaminar Fracture Toughness

    Directory of Open Access Journals (Sweden)

    CHEN Xingyi

    2016-10-01

    Full Text Available In order to compare and analyse the effect of two different kinds of forming process on composite mode I interlaminar fracture toughness, the DCB specimens were tested by using hypothesis inspeetion method.A finite element model was also used to simulate the crack propagation process.The results demonstrate that the average of mode I interlaminar fracture toughness from silicon rubber flexible mold forming is a bit higher than that from metal rigid mold forming.Howevers the variance of mode I interlaminar fracture toughness from the two groups shows no significant difference.The crack propagation process of the two forming process is similar. The established finite element model, which is identical to the test results, can predict the process of the crack expansion effectively.

  12. Mobile Ultrasound Plane Wave Beamforming on iPhone or iPad using Metal- based GPU Processing

    Science.gov (United States)

    Hewener, Holger J.; Tretbar, Steffen H.

    Mobile and cost effective ultrasound devices are being used in point of care scenarios or the drama room. To reduce the costs of such devices we already presented the possibilities of consumer devices like the Apple iPad for full signal processing of raw data for ultrasound image generation. Using technologies like plane wave imaging to generate a full image with only one excitation/reception event the acquisition times and power consumption of ultrasound imaging can be reduced for low power mobile devices based on consumer electronics realizing the transition from FPGA or ASIC based beamforming into more flexible software beamforming. The massive parallel beamforming processing can be done with the Apple framework "Metal" for advanced graphics and general purpose GPU processing for the iOS platform. We were able to integrate the beamforming reconstruction into our mobile ultrasound processing application with imaging rates up to 70 Hz on iPad Air 2 hardware.

  13. A possible extension to the RInChI as a means of providing machine readable process data.

    Science.gov (United States)

    Jacob, Philipp-Maximilian; Lan, Tian; Goodman, Jonathan M; Lapkin, Alexei A

    2017-04-11

    The algorithmic, large-scale use and analysis of reaction databases such as Reaxys is currently hindered by the absence of widely adopted standards for publishing reaction data in machine readable formats. Crucial data such as yields of all products or stoichiometry are frequently not explicitly stated in the published papers and, hence, not reported in the database entry for those reactions, limiting their usefulness for algorithmic analysis. This paper presents a possible extension to the IUPAC RInChI standard via an auxiliary layer, termed ProcAuxInfo, which is a standardised, extensible form in which to report certain key reaction parameters such as declaration of all products and reactants as well as auxiliaries known in the reaction, reaction stoichiometry, amounts of substances used, conversion, yield and operating conditions. The standard is demonstrated via creation of the RInChI including the ProcAuxInfo layer based on three published reactions and demonstrates accurate data recoverability via reverse translation of the created strings. Implementation of this or another method of reporting process data by the publishing community would ensure that databases, such as Reaxys, would be able to abstract crucial data for big data analysis of their contents.

  14. iMAGE cloud: medical image processing as a service for regional healthcare in a hybrid cloud environment.

    Science.gov (United States)

    Liu, Li; Chen, Weiping; Nie, Min; Zhang, Fengjuan; Wang, Yu; He, Ailing; Wang, Xiaonan; Yan, Gen

    2016-11-01

    To handle the emergence of the regional healthcare ecosystem, physicians and surgeons in various departments and healthcare institutions must process medical images securely, conveniently, and efficiently, and must integrate them with electronic medical records (EMRs). In this manuscript, we propose a software as a service (SaaS) cloud called the iMAGE cloud. A three-layer hybrid cloud was created to provide medical image processing services in the smart city of Wuxi, China, in April 2015. In the first step, medical images and EMR data were received and integrated via the hybrid regional healthcare network. Then, traditional and advanced image processing functions were proposed and computed in a unified manner in the high-performance cloud units. Finally, the image processing results were delivered to regional users using the virtual desktop infrastructure (VDI) technology. Security infrastructure was also taken into consideration. Integrated information query and many advanced medical image processing functions-such as coronary extraction, pulmonary reconstruction, vascular extraction, intelligent detection of pulmonary nodules, image fusion, and 3D printing-were available to local physicians and surgeons in various departments and healthcare institutions. Implementation results indicate that the iMAGE cloud can provide convenient, efficient, compatible, and secure medical image processing services in regional healthcare networks. The iMAGE cloud has been proven to be valuable in applications in the regional healthcare system, and it could have a promising future in the healthcare system worldwide.

  15. Quantum state-to-state dynamics for the quenching process of Br(2P1/2) + H2(v(i) = 0, 1, j(i) = 0).

    Science.gov (United States)

    Xie, Changjian; Jiang, Bin; Xie, Daiqian; Sun, Zhigang

    2012-03-21

    Quantum state-to-state dynamics for the quenching process Br((2)P(1/2)) + H(2)(v(i) = 0, 1, j(i) = 0) → Br((2)P(3/2)) + H(2)(v(f), j(f)) has been studied based on two-state model on the recent coupled potential energy surfaces. It was found that the quenching probabilities have some oscillatory structures due to the interference of reflected flux in the Br((2)P(1/2)) + H(2) and Br((2)P(3/2)) + H(2) channels by repulsive potential in the near-resonant electronic-to-vibrational energy transfer process. The final vibrational state resolved integral cross sections were found to be dominated by the quenching process Br((2)P(1/2)) + H(2)(v) → Br((2)P(3/2)) + H(2)(v+1) and the nonadiabatic reaction probabilities for Br((2)P(1/2)) + H(2)(v = 0, 1, j(i) = 0) are quite small, which are consistent with previous theoretical and experimental results. Our calculated total quenching rate constant for Br((2)P(1/2)) + H(2)(v(i) = 0, j(i) = 0) at room temperature is in good agreement with the available experimental data. © 2012 American Institute of Physics

  16. MMX-I: A data-processing software for multi-modal X-ray imaging and tomography

    International Nuclear Information System (INIS)

    Bergamaschi, A; Medjoubi, K; Somogyi, A; Messaoudi, C; Marco, S

    2017-01-01

    Scanning hard X-ray imaging allows simultaneous acquisition of multimodal information, including X-ray fluorescence, absorption, phase and dark-field contrasts, providing structural and chemical details of the samples. Combining these scanning techniques with the infrastructure developed for fast data acquisition at Synchrotron Soleil permits to perform multimodal imaging and tomography during routine user experiments at the Nanoscopium beamline. A main challenge of such imaging techniques is the online processing and analysis of the generated very large volume (several hundreds of Giga Bytes) multimodal data-sets. This is especially important for the wide user community foreseen at the user oriented Nanoscopium beamline (e.g. from the fields of Biology, Life Sciences, Geology, Geobiology), having no experience in such data-handling. MMX-I is a new multi-platform open-source freeware for the processing and reconstruction of scanning multi-technique X-ray imaging and tomographic datasets. The MMX-I project aims to offer, both expert users and beginners, the possibility of processing and analysing raw data, either on-site or off-site. Therefore we have developed a multi-platform (Mac, Windows and Linux 64bit) data processing tool, which is easy to install, comprehensive, intuitive, extendable and user-friendly. MMX-I is now routinely used by the Nanoscopium user community and has demonstrated its performance in treating big data. (paper)

  17. MMX-I: A data-processing software for multi-modal X-ray imaging and tomography

    Science.gov (United States)

    Bergamaschi, A.; Medjoubi, K.; Messaoudi, C.; Marco, S.; Somogyi, A.

    2017-06-01

    Scanning hard X-ray imaging allows simultaneous acquisition of multimodal information, including X-ray fluorescence, absorption, phase and dark-field contrasts, providing structural and chemical details of the samples. Combining these scanning techniques with the infrastructure developed for fast data acquisition at Synchrotron Soleil permits to perform multimodal imaging and tomography during routine user experiments at the Nanoscopium beamline. A main challenge of such imaging techniques is the online processing and analysis of the generated very large volume (several hundreds of Giga Bytes) multimodal data-sets. This is especially important for the wide user community foreseen at the user oriented Nanoscopium beamline (e.g. from the fields of Biology, Life Sciences, Geology, Geobiology), having no experience in such data-handling. MMX-I is a new multi-platform open-source freeware for the processing and reconstruction of scanning multi-technique X-ray imaging and tomographic datasets. The MMX-I project aims to offer, both expert users and beginners, the possibility of processing and analysing raw data, either on-site or off-site. Therefore we have developed a multi-platform (Mac, Windows and Linux 64bit) data processing tool, which is easy to install, comprehensive, intuitive, extendable and user-friendly. MMX-I is now routinely used by the Nanoscopium user community and has demonstrated its performance in treating big data.

  18. Novel laser-processed CsI:Tl detector for SPECT

    Energy Technology Data Exchange (ETDEWEB)

    Sabet, H., E-mail: hsabet@mgh.harvard.edu; Uzun-Ozsahin, D.; El-Fakhri, G. [Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129 (United States); Bläckberg, L. [Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02129 and Department of Physics and Astronomy, Uppsala University, Uppsala 75120 (Sweden)

    2016-05-15

    Purpose: The aim of this work is to demonstrate the feasibility of a novel technique for fabrication of high spatial resolution CsI:Tl scintillation detectors for single photon emission computed tomography systems. Methods: The scintillators are fabricated using laser-induced optical barriers technique to create optical microstructures (or optical barriers) inside the CsI:Tl crystal bulk. The laser-processed CsI:Tl crystals are 3, 5, and 10 mm in thickness. In this work, the authors focus on the simplest pattern of optical barriers in that the barriers are created in the crystal bulk to form pixel-like patterns resembling mechanically pixelated scintillators. The monolithic CsI:Tl scintillator samples are fabricated with optical barrier patterns with 1.0 × 1.0 mm{sup 2} and 0.625 × 0.625 mm{sup 2} pixels. Experiments were conducted to characterize the fabricated arrays in terms of pixel separation and energy resolution. A 4 × 4 array of multipixel photon counter was used to collect the scintillation light in all the experiments. Results: The process yield for fabricating the CsI:Tl arrays is 100% with processing time under 50 min. From the flood maps of the fabricated detectors exposed to 122 keV gammas, peak-to-valley (P/V) ratios of greater than 2.3 are calculated. The P/V values suggest that regardless of the crystal thickness, the pixels can be resolved. Conclusions: The results suggest that optical barriers can be considered as a robust alternative to mechanically pixelated arrays and can provide high spatial resolution while maintaining the sensitivity in a high-throughput and cost-effective manner.

  19. Novel laser-processed CsI:Tl detector for SPECT

    International Nuclear Information System (INIS)

    Sabet, H.; Uzun-Ozsahin, D.; El-Fakhri, G.; Bläckberg, L.

    2016-01-01

    Purpose: The aim of this work is to demonstrate the feasibility of a novel technique for fabrication of high spatial resolution CsI:Tl scintillation detectors for single photon emission computed tomography systems. Methods: The scintillators are fabricated using laser-induced optical barriers technique to create optical microstructures (or optical barriers) inside the CsI:Tl crystal bulk. The laser-processed CsI:Tl crystals are 3, 5, and 10 mm in thickness. In this work, the authors focus on the simplest pattern of optical barriers in that the barriers are created in the crystal bulk to form pixel-like patterns resembling mechanically pixelated scintillators. The monolithic CsI:Tl scintillator samples are fabricated with optical barrier patterns with 1.0 × 1.0 mm"2 and 0.625 × 0.625 mm"2 pixels. Experiments were conducted to characterize the fabricated arrays in terms of pixel separation and energy resolution. A 4 × 4 array of multipixel photon counter was used to collect the scintillation light in all the experiments. Results: The process yield for fabricating the CsI:Tl arrays is 100% with processing time under 50 min. From the flood maps of the fabricated detectors exposed to 122 keV gammas, peak-to-valley (P/V) ratios of greater than 2.3 are calculated. The P/V values suggest that regardless of the crystal thickness, the pixels can be resolved. Conclusions: The results suggest that optical barriers can be considered as a robust alternative to mechanically pixelated arrays and can provide high spatial resolution while maintaining the sensitivity in a high-throughput and cost-effective manner.

  20. A sensor network to iPhone interface separating continuous and sporadic processes in mobile telemedicine.

    Science.gov (United States)

    D'Angelo, Lorenzo T; Schneider, Michael; Neugebauer, Paul; Lueth, Tim C

    2011-01-01

    In this contribution, a new concept for interfacing sensor network nodes (motes) and smartphones is presented for the first time. In the last years, a variety of telemedicine applications on smartphones for data reception, display and transmission have been developed. However, it is not always practical or possible to have a smartphone application running continuously to accomplish these tasks. The presented system allows receiving and storing data continuously using a mote and visualizing or sending it on the go using the smartphone as user interface only when desired. Thus, the processes of data reception and storage run on a safe system consuming less energy and the smartphone's potential along with its battery are not demanded continuously. Both, system concept and realization with an Apple iPhone are presented.

  1. Design and construction of a shielded process box for the production of radiopharmaceuticals labelled with 131I

    International Nuclear Information System (INIS)

    Bonetto, O.; Goso, R.; Guerrero, G.; Huala, H.E.; Logusso, N.A.; Marques, R.; Mitta, A.E.A.

    1976-07-01

    A leakproof process box, shielded with a 5 mm lead wall, for the labelling, purification, pH adjutment and dispensing of Rose Bengal 131 I, Hippuran 131 I, Diprocon 131 I, Hipaque 131 I, Bromosuphthalein 131 I, etc. is described. (author) [es

  2. Electron Transfer from Triplet State of TIPS-Pentacene Generated by Singlet Fission Processes to CH3NH3PbI3 Perovskite.

    Science.gov (United States)

    Lee, Sangsu; Hwang, Daesub; Jung, Seok Il; Kim, Dongho

    2017-02-16

    To reveal the applicability of singlet fission processes in perovskite solar cell, we investigated electron transfer from TIPS-pentacene to CH 3 NH 3 PbI 3 (MAPbI 3 ) perovskite in film phase. Through the observation of the shorter fluorescence lifetime in TIPS-pentacene/MAPbI 3 perovskite bilayer film (5 ns) compared with pristine MAPbI 3 perovskite film (20 ns), we verified electron-transfer processes between TIPS-pentacene and MAPbI 3 perovskite. Furthermore, the observation of singlet fission processes, a faster decay rate, TIPS-pentacene cations, and the analysis of kinetic profiles of the intensity ratio between 500 and 525 nm in the TA spectra of the TIPS-pentacene/MAPbI 3 perovskite bilayer film indicate that electron transfer occurs from triplet state of TIPS-pentacene generated by singlet fission processes to MAPbI 3 perovskite conduction band. We believe that our results can provide useful information on the design of solar cells sensitized by singlet fission processes and pave the way for new types of perovskite solar cells.

  3. 21 CFR 212.50 - What production and process controls must I have?

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 4 2010-04-01 2010-04-01 false What production and process controls must I have... DRUGS (Eff. 12-12-2011) Production and Process Controls § 212.50 What production and process controls must I have? You must have adequate production and process controls to ensure the consistent production...

  4. Congressional Submission RDT&E Descriptive Summaries, FY 1994

    Science.gov (United States)

    1993-04-01

    U) Extremely High Frequency (EHF) lower cost, communication technologies ( ASTEC ) will be developed to support the ASD/C 3 1 MILSATCOM modernization...restructured and formalized into the ASTEC , CAMEO and IMPACT Programs. F. (U) PROGRAM DOCUMENTATION: * (U) U.S. Air Force/DARPA MOA dated 1988 * (U) U.S...Army/DARPA MOA dated 1990 * (U) SDIO/DARPA MOA dated 1990 * (U) DARPA/U.S. Air Force TAOS MOA dated 1992 * (U) DARPA/Joint Services ASTEC MOA (in

  5. Identification of AR(I)MA processes for modelling temporal correlations of GPS observations

    Science.gov (United States)

    Luo, X.; Mayer, M.; Heck, B.

    2009-04-01

    In many geodetic applications observations of the Global Positioning System (GPS) are routinely processed by means of the least-squares method. However, this algorithm delivers reliable estimates of unknown parameters und realistic accuracy measures only if both the functional and stochastic models are appropriately defined within GPS data processing. One deficiency of the stochastic model used in many GPS software products consists in neglecting temporal correlations of GPS observations. In practice the knowledge of the temporal stochastic behaviour of GPS observations can be improved by analysing time series of residuals resulting from the least-squares evaluation. This paper presents an approach based on the theory of autoregressive (integrated) moving average (AR(I)MA) processes to model temporal correlations of GPS observations using time series of observation residuals. A practicable integration of AR(I)MA models in GPS data processing requires the determination of the order parameters of AR(I)MA processes at first. In case of GPS, the identification of AR(I)MA processes could be affected by various factors impacting GPS positioning results, e.g. baseline length, multipath effects, observation weighting, or weather variations. The influences of these factors on AR(I)MA identification are empirically analysed based on a large amount of representative residual time series resulting from differential GPS post-processing using 1-Hz observation data collected within the permanent SAPOS® (Satellite Positioning Service of the German State Survey) network. Both short and long time series are modelled by means of AR(I)MA processes. The final order parameters are determined based on the whole residual database; the corresponding empirical distribution functions illustrate that multipath and weather variations seem to affect the identification of AR(I)MA processes much more significantly than baseline length and observation weighting. Additionally, the modelling

  6. Pharmacy on demand: New technologies to enable miniaturized and mobile drug manufacturing.

    Science.gov (United States)

    Lewin, John J; Choi, Eugene J; Ling, Geoffrey

    2016-01-15

    Developmental pharmaceutical manufacturing systems and techniques designed to overcome the shortcomings of traditional batch processing methods are described. Conventional pharmaceutical manufacturing processes do not adequately address the needs of military and civilian patient populations and healthcare providers. Recent advances within the Defense Advanced Research Projects Agency (DARPA) Battlefield Medicine program suggest that miniaturized, flexible platforms for end-to-end manufacturing of pharmaceuticals are possible. Advances in continuous-flow synthesis, chemistry, biological engineering, and downstream processing, coupled with online analytics, automation, and enhanced process control measures, pave the way for disruptive innovation to improve the pharmaceutical supply chain and drug manufacturing base. These new technologies, along with current and ongoing advances in regulatory science, have the future potential to (1) permit "on demand" drug manufacturing on the battlefield and in other austere environments, (2) enhance the level of preparedness for chemical, biological, radiological, and nuclear threats, (3) enhance health authorities' ability to respond to natural disasters and other catastrophic events, (4) minimize shortages of drugs, (5) address gaps in the orphan drug market, (6) support and enable the continued drive toward precision medicine, and (7) enhance access to needed medications in underserved areas across the globe. Modular platforms under development by DARPA's Battlefield Medicine program may one day improve the safety, efficiency, and timeliness of drug manufacturing. Copyright © 2016 by the American Society of Health-System Pharmacists, Inc. All rights reserved.

  7. Bantam: A Cautionary Tale

    Science.gov (United States)

    McNeal, Curtis I., Jr.

    2004-01-01

    This viewgraph presentation reviews the history of the Bantam program that was cancelled in 1999 due to the decision that the focus on the small payloads was unsustainable and that there would be no return on investment. The comparison is made between NASA's Bantam program, and DARPA's (Defense Advanced Research Projects Agency) two similar projects (Falcon and Rascal). The Bantam Program was to be a small launch vehicle, aimed at launching small payloads (i.e., of 150-300 kg) into space.

  8. Dignital Biological Converter

    Science.gov (United States)

    2014-01-03

    DARPA Contracting Officer: Michael Blackstone Submitted by: HEATHER GOUVIS Synthetic Genomics, Inc. 11149 NORTH TORREY PINES RD LA JOLLA, CA...Contracting Officer Representative (COR) Email: salit@nist.gov Michael Blackstone DARPA Contracting Officer Michael.Blackstone@darpa.mil DARPA

  9. iPSC-Based Models to Unravel Key Pathogenetic Processes Underlying Motor Neuron Disease Development

    Directory of Open Access Journals (Sweden)

    Irene Faravelli

    2014-10-01

    Full Text Available Motor neuron diseases (MNDs are neuromuscular disorders affecting rather exclusively upper motor neurons (UMNs and/or lower motor neurons (LMNs. The clinical phenotype is characterized by muscular weakness and atrophy leading to paralysis and almost invariably death due to respiratory failure. Adult MNDs include sporadic and familial amyotrophic lateral sclerosis (sALS-fALS, while the most common infantile MND is represented by spinal muscular atrophy (SMA. No effective treatment is ccurrently available for MNDs, as for the vast majority of neurodegenerative disorders, and cures are limited to supportive care and symptom relief. The lack of a deep understanding of MND pathogenesis accounts for the difficulties in finding a cure, together with the scarcity of reliable in vitro models. Recent progresses in stem cell field, in particular in the generation of induced Pluripotent Stem Cells (iPSCs has made possible for the first time obtaining substantial amounts of human cells to recapitulate in vitro some of the key pathogenetic processes underlying MNDs. In the present review, recently published studies involving the use of iPSCs to unravel aspects of ALS and SMA pathogenesis are discussed with an overview of their implications in the process of finding a cure for these still orphan disorders.

  10. Evaluation of mercury in liquid waste processing facilities - Phase I report

    Energy Technology Data Exchange (ETDEWEB)

    Jain, V. [Savannah River Site (SRS), Aiken, SC (United States); Occhipinti, J. E. [Savannah River Site (SRS), Aiken, SC (United States); Shah, H. [Savannah River Site (SRS), Aiken, SC (United States); Wilmarth, W. R. [Savannah River Site (SRS), Aiken, SC (United States); Edwards, R. E. [Savannah River Site (SRS), Aiken, SC (United States)

    2015-07-01

    This report provides a summary of Phase I activities conducted to support an Integrated Evaluation of Mercury in Liquid Waste System (LWS) Processing Facilities. Phase I activities included a review and assessment of the liquid waste inventory and chemical processing behavior of mercury using a system by system review methodology approach. Gaps in understanding mercury behavior as well as action items from the structured reviews are being tracked. 64% of the gaps and actions have been resolved.

  11. Evaluation of Mercury in Liquid Waste Processing Facilities - Phase I Report

    Energy Technology Data Exchange (ETDEWEB)

    Jain, V. [Savannah River Site (SRS), Aiken, SC (United States); Occhipinti, J. [Savannah River Site (SRS), Aiken, SC (United States); Shah, H. [Savannah River Site (SRS), Aiken, SC (United States); Wilmarth, B. [Savannah River Site (SRS), Aiken, SC (United States); Edwards, R. [Savannah River Site (SRS), Aiken, SC (United States)

    2015-07-01

    This report provides a summary of Phase I activities conducted to support an Integrated Evaluation of Mercury in Liquid Waste System (LWS) Processing Facilities. Phase I activities included a review and assessment of the liquid waste inventory and chemical processing behavior of mercury using a system by system review methodology approach. Gaps in understanding mercury behavior as well as action items from the structured reviews are being tracked. 64% of the gaps and actions have been resolved.

  12. Information Processing in Adolescents with Bipolar I Disorder

    Science.gov (United States)

    Whitney, Jane; Joormann, Jutta; Gotlib, Ian H.; Kelley, Ryan G.; Acquaye, Tenah; Howe, Meghan; Chang, Kiki D.; Singh, Manpreet K.

    2012-01-01

    Background: Cognitive models of bipolar I disorder (BD) may aid in identification of children who are especially vulnerable to chronic mood dysregulation. Information-processing biases related to memory and attention likely play a role in the development and persistence of BD among adolescents; however, these biases have not been extensively…

  13. Designing future learning. A posthumanist approach to researching design processes

    DEFF Research Database (Denmark)

    Juelskjær, Malou

    I investigate how a design process – leading up to the design of a new education building - enact, transform and highlight tacit everyday practices and experiences in an education setting, whereby becoming an art of managing. I apply a post-humanist performative perspective, highlighting entangled...... agencies rather than focusing on human agency. I focus on the design process rather than the designer. The design process accelerated and performed past and future experiences of schooling, learning, teaching. This called for analytical attention to agential forces of not only the material but also...... and temporalities matter in design processes. Furthermore, the analysis emphasise how design translate affective economies and that attention to those affective economies are vital for the result of the design process....

  14. Defective HLA class I antigen processing machinery in cancer.

    Science.gov (United States)

    Cai, Lei; Michelakos, Theodoros; Yamada, Teppei; Fan, Song; Wang, Xinhui; Schwab, Joseph H; Ferrone, Cristina R; Ferrone, Soldano

    2018-02-27

    Malignant transformation of cells is frequently associated with defective HLA class I antigen processing machinery (APM) component expression. This abnormality may have functional relevance, since it may have a negative impact on tumor cell recognition by cognate T cells. Furthermore, HLA class I APM abnormalities appear to have clinical significance, since they are associated with poor prognosis in several malignant diseases and may play a role in the resistance to immune checkpoint inhibitor-based immunotherapy. In this paper, we have reviewed the literature describing abnormalities in HLA class I APM component expression in many types of cancer. These abnormalities have been reported in all types of cancer analyzed with a frequency ranging between a minimum of 35.8% in renal cancer and a maximum of 87.9% in thyroid cancer for HLA class I heavy chains. In addition, we have described the molecular mechanisms underlying defects in HLA class I APM component expression and function by malignant cells. Lastly, we have discussed the clinical significance of HLA class I APM component abnormalities in malignant tumors.

  15. TRAQ I, a CAMAC system for multichannel data acquisition, storage and processing

    International Nuclear Information System (INIS)

    Broad, A.S.; Jordan, C.L.; Kojola, P.H.; Miller, M.

    1983-01-01

    Multichannel, high speed, signal sources generate large amounts of data which cannot be handled real time on the camac dataway. TRAQ I is a modular CAMAC system designed to buffer and process data of this type. The system can acquire data from up to 256 sources (ADCs etc.) and store in local memory (4 Mbytes). Many different signal sources can be controlled, working in either a histogramming or sequential mode. The system's data transfer bus is designed to accommodate other modules which can pre- or postprocess the data. Pre-processors can either intercept the data flow to memory for data compaction or passively monitor, looking for signal excursions, etc. Post-processors access memory to process and rewrite the data or transmit to other devices

  16. Friction Stir Processing of Cast Superalloys, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — This SBIR Phase I effort examines the feasibility of an innovative fabrication technology incorporating sand casting and friction stir processing (FSP) for producing...

  17. How I Learned to Swim: The Visual Journal as a Companion to Creative Inquiry

    Science.gov (United States)

    Scott Shields, Sara

    2016-01-01

    In this paper, I discuss my engagement with a visual journal as a companion to creative research practice during my dissertation research. Grounded in arts based research methodologies; I explore visual journals in relationship to research, reflection and analytic processes. I begin with a discussion of the visual journal as an artifact of…

  18. Apolipoprotein A-I configuration and cell cholesterol efflux activity of discoidal lipoproteins depend on the reconstitution process.

    Science.gov (United States)

    Cuellar, Luz Ángela; Prieto, Eduardo Daniel; Cabaleiro, Laura Virginia; Garda, Horacio Alberto

    2014-01-01

    Discoidal high-density lipoproteins (D-HDL) are critical intermediates in reverse cholesterol transport. Most of the present knowledge of D-HDL is based on studies with reconstituted lipoprotein complexes of apolipoprotein A-I (apoA-I) obtained by cholate dialysis (CD). D-HDL can also be generated by the direct microsolubilization (DM) of phospholipid vesicles at the gel/fluid phase transition temperature, a process mechanistically similar to the "in vivo" apoAI lipidation via ABCA1. We compared the apoA-I configuration in D-HDL reconstituted with dimyristoylphosphatidylcholine by both procedures using fluorescence resonance energy transfer measurements with apoA-I tryptophan mutants and fluorescently labeled cysteine mutants. Results indicate that apoA-I configuration in D-HDL depends on the reconstitution process and are consistent with a "double belt" molecular arrangement with different helix registry. As reported by others, a configuration with juxtaposition of helices 5 of each apoAI monomer (5/5 registry) predominates in D-HDL obtained by CD. However, a configuration with helix 5 of one monomer juxtaposed with helix 2 of the other (5/2 registry) would predominate in D-HDL generated by DM. Moreover, we also show that the kinetics of cholesterol efflux from macrophage cultures depends on the reconstitution process, suggesting that apoAI configuration is important for this HDL function. Copyright © 2013 Elsevier B.V. All rights reserved.

  19. Process variables consistency at Atucha I NPP

    International Nuclear Information System (INIS)

    Arostegui, E.; Aparicio, M.; Herzovich, P.; Wenzel, J.; Urrutia, G.

    1996-01-01

    A method to evaluate the different systems performance has been developed and is still under assessment. In order to perform this job a process computer upgraded in 1992 was used. In this sense and taking into account that the resolution and stability of instrumentation is higher than its accuracy process data were corrected by software. In this was, much time spent in recalibration, and also human errors were avoided. Besides, this method allowed a better record of instrumentation performance and also an early detection of instruments failure. On the other hand, the process modelization, mainly heat and material balances has also been used to check that sensors, transducers, analog to digital converters and computer software are working properly. Some of these process equations have been introduced into the computer codes, so in some cases, it is possible to have an ''on line'' analysis of process variables and process instrumentation behaviour. Examples of process analysis are: Heat exchangers, i.e. the power calculated using shell side temperatures is compared with the tube side values; turbine performance is compared with condenser water temperature; power measured on the secondary side (one minute average measurements optimized in order to eliminate process noise are compared with power obtained from primary side data); the calibration of temperatures have been made by direct measurement of redundant sensors and have shown to be the best method; in the case of pressure and differential pressure transducers are cross checked in service when it is possible. In the present paper, details of the examples mentioned above and of other ones are given and discussed. (author). 2 refs, 1 fig., 1 tab

  20. Process variables consistency at Atucha I NPP

    Energy Technology Data Exchange (ETDEWEB)

    Arostegui, E; Aparicio, M; Herzovich, P; Wenzel, J [Central Nuclear Atucha I, Nucleoelectrica S.A., Lima, Buenos Aires (Argentina); Urrutia, G [Comision Nacional de Energia Atomica, Buenos Aires (Argentina)

    1997-12-31

    A method to evaluate the different systems performance has been developed and is still under assessment. In order to perform this job a process computer upgraded in 1992 was used. In this sense and taking into account that the resolution and stability of instrumentation is higher than its accuracy process data were corrected by software. In this was, much time spent in recalibration, and also human errors were avoided. Besides, this method allowed a better record of instrumentation performance and also an early detection of instruments failure. On the other hand, the process modelization, mainly heat and material balances has also been used to check that sensors, transducers, analog to digital converters and computer software are working properly. Some of these process equations have been introduced into the computer codes, so in some cases, it is possible to have an ``on line`` analysis of process variables and process instrumentation behaviour. Examples of process analysis are: Heat exchangers, i.e. the power calculated using shell side temperatures is compared with the tube side values; turbine performance is compared with condenser water temperature; power measured on the secondary side (one minute average measurements optimized in order to eliminate process noise are compared with power obtained from primary side data); the calibration of temperatures have been made by direct measurement of redundant sensors and have shown to be the best method; in the case of pressure and differential pressure transducers are cross checked in service when it is possible. In the present paper, details of the examples mentioned above and of other ones are given and discussed. (author). 2 refs, 1 fig., 1 tab.

  1. An efficient synthesis of isocoumarins via a CuI catalyzed cascade reaction process

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    3-Alkyl isocoumarins are provided by CuI/amino acid-catalyzed Sonogashira coupling reaction of o-bromo benzoic acids and terminal alkynes and the subsequent additive cyclization. This cascade process allows synthesis of diverse isocoumarins by varying both coupling partners bearing a wide range of functional groups.

  2. Building a Library for Microelectronics Verification with Topological Constraints

    Science.gov (United States)

    2017-03-01

    with topological constraints. Circuits at the second level of abstraction are selected from prior work on simulated reverse- engineered hardware...entering DoD systems. The Defense Advanced Research Project Agency (DARPA) Trusted Integrated Circuits (TRUST) [12-14] program was introduced to focus on...serious- risks-from-counterfeit-electronic-parts/ 4. “Trusted Integrated Circuits (TRUST)”. [Online]. DARPA Microsystems Technology Office. Available

  3. HLA class I is most tightly linked to levels of tapasin compared with other antigen-processing proteins in glioblastoma.

    Science.gov (United States)

    Thuring, Camilla; Follin, Elna; Geironson, Linda; Freyhult, Eva; Junghans, Victoria; Harndahl, Mikkel; Buus, Søren; Paulsson, Kajsa M

    2015-09-15

    Tumour cells can evade the immune system by dysregulation of human leukocyte antigens (HLA-I). Low quantity and/or altered quality of HLA-I cell surface expression is the result of either HLA-I alterations or dysregulations of proteins of the antigen-processing machinery (APM). Tapasin is an APM protein dedicated to the maturation of HLA-I and dysregulation of tapasin has been linked to higher malignancy in several different tumours. We studied the expression of APM components and HLA-I, as well as HLA-I tapasin-dependency profiles in glioblastoma tissues and corresponding cell lines. Tapasin displayed the strongest correlation to HLA-I heavy chain but also clustered with β2-microglobulin, transporter associated with antigen processing (TAP) and LMP. Moreover, tapasin also correlated to survival of glioblastoma patients. Some APM components, for example, TAP1/TAP2 and LMP2/LMP7, showed variable but coordinated expression, whereas ERAP1/ERAP2 displayed an imbalanced expression pattern. Furthermore, analysis of HLA-I profiles revealed variable tapasin dependence of HLA-I allomorphs in glioblastoma patients. Expression of APM proteins is highly variable between glioblastomas. Tapasin stands out as the APM component strongest correlated to HLA-I expression and we proved that HLA-I profiles in glioblastoma patients include tapasin-dependent allomorphs. The level of tapasin was also correlated with patient survival time. Our results support the need for individualisation of immunotherapy protocols.

  4. Life cycle assessment of hydrogen production from S-I thermochemical process coupled to a high temperature gas reactor

    Energy Technology Data Exchange (ETDEWEB)

    Giraldi, M. R.; Francois, J. L.; Castro-Uriegas, D. [Departamento de Sistemas Energeticos, Facultad de Ingenieria, Universidad Nacional Autonoma de Mexico, Paseo Cuauhnahuac No. 8532, Col. Progreso, C.P. 62550, Jiutepec, Morelos (Mexico)

    2012-07-01

    The purpose of this paper is to quantify the greenhouse gas (GHG) emissions associated to the hydrogen produced by the sulfur-iodine thermochemical process, coupled to a high temperature nuclear reactor, and to compare the results with other life cycle analysis (LCA) studies on hydrogen production technologies, both conventional and emerging. The LCA tool was used to quantify the impacts associated with climate change. The product system was defined by the following steps: (i) extraction and manufacturing of raw materials (upstream flows), (U) external energy supplied to the system, (iii) nuclear power plant, and (iv) hydrogen production plant. Particular attention was focused to those processes where there was limited information from literature about inventory data, as the TRISO fuel manufacture, and the production of iodine. The results show that the electric power, supplied to the hydrogen plant, is a sensitive parameter for GHG emissions. When the nuclear power plant supplied the electrical power, low GHG emissions were obtained. These results improve those reported by conventional hydrogen production methods, such as steam reforming. (authors)

  5. Proteolytic enzymes involved in MHC class I antigen processing: A guerrilla army that partners with the proteasome.

    Science.gov (United States)

    Lázaro, Silvia; Gamarra, David; Del Val, Margarita

    2015-12-01

    Major histocompatibility complex class I proteins (MHC-I) load short peptides derived from proteolytic cleavage of endogenous proteins in any cell of the body, in a process termed antigen processing and presentation. When the source proteins are altered self or encoded by a pathogen, recognition of peptide/MHC-I complexes at the plasma membrane leads to CD8(+) T-lymphocyte responses that clear infections and probably underlie tumor immune surveillance. On the other hand, presentation of self peptides may cause some types of autoimmunity. The peptides that are presented determine the specificity and efficiency of pathogen clearance or, conversely, of immunopathology. In this review we highlight the growing number of peptidases which, as a by-product of their regular activity, can generate peptide epitopes for immune surveillance. These ∼20 peptidases collectively behave as a guerrilla army partnering with the regular proteasome army in generating a variety of peptides for presentation by MHC-I and thus optimally signaling infection. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

  6. DSP for Matlab and Labview I fundamentals of discrete signal processing

    CERN Document Server

    Isen, Forester W

    2009-01-01

    This book is Volume I of the series DSP for MATLAB™ and LabVIEW™. The entire series consists of four volumes that collectively cover basic digital signal processing in a practical and accessible manner, but which nonetheless include all essential foundation mathematics. As the series title implies, the scripts (of which there are more than 200) described in the text and supplied in code form here will run on both MATLAB and LabVIEW. Volume I consists of four chapters. The first chapter gives a brief overview of the field of digital signal processing. This is followed by a chapter detailing man

  7. Development of procedure using plasma welding process to produce {sup 125}I seeds; Desenvolvimento de procedimento utilizando processo de soldagem plasma para confeccao de sementes de {sup 125}I

    Energy Technology Data Exchange (ETDEWEB)

    Feher, Anselmo

    2006-07-01

    The prostate cancer, which is the second cause of death by cancer in men, overcome only by lung cancer, is a problem of public health in Brazil. Brachytherapy is among the possible available treatments for prostate cancer, in which small seeds containing {sup 125}I radioisotope are implanted in the prostate. The seed consists of a titanium sealed capsule with 0.8 mm external diameter and 4.5 mm length, containing a central silver wire with adsorbed {sup 125}I. The plasma arc welding is one of the viable techniques for the sealing process. The equipment used in this technique is less costly than in other processes. The main objective of this work was the development and the validation of the welding procedure using plasma welding process and the elaboration of a sealing routine according to Good Manufacturing Practices. The development of this work has presented the following phases: cut and cleaning of the titanium material, determination of the welding parameters, development of a device for holding the titanium tube during the welding process, validation of sealed sources according to ISO 2919 Sealed Radioactive Sources - General Requirements and Classification, leakage test according to ISO 9978 Sealed Radioactive Sources - Leakage Test Methods and metallographic assays. The developed procedure, to seal {sup 125}I seeds using plasma welding process, has shown to be efficient, satisfying all the established requirements of ISO 2919. The results obtained in this work have given the possibility to establish a routine production process according to the orientations presented in resolution RDC number 59 - Good Manufacturing Practices do Medical Products of the ANVISA - Brazilian Nacional Agency of Sanitary Surveillance. (author)

  8. Teaching iSTART to Understand Spanish

    Science.gov (United States)

    Dascalu, Mihai; Jacovina, Matthew E.; Soto, Christian M.; Allen, Laura K.; Dai, Jianmin; Guerrero, Tricia A.; McNamara, Danielle S.

    2017-01-01

    iSTART is a web-based reading comprehension tutor. A recent translation of iSTART from English to Spanish has made the system available to a new audience. In this paper, we outline several challenges that arose during the development process, specifically focusing on the algorithms that drive the feedback. Several iSTART activities encourage…

  9. [Optimization of process of icraiin be hydrolyzed to Baohuoside I by cellulase based on Plackett-Burman design combined with CCD response surface methodology].

    Science.gov (United States)

    Song, Chuan-xia; Chen, Hong-mei; Dai, Yu; Kang, Min; Hu, Jia; Deng, Yun

    2014-11-01

    To optimize the process of Icraiin be hydrolyzed to Baohuoside I by cellulase by Plackett-Burman design combined with Central Composite Design (CCD) response surface methodology. To select the main influencing factors by Plackett-Burman design, using CCD response surface methodology to optimize the process of Icraiin be hydrolyzed to Baohuoside I by cellulase. Taking substrate concentration, the pH of buffer and reaction time as independent variables, with conversion rate of icariin as dependent variable,using regression fitting of completely quadratic response surface between independent variable and dependent variable,the optimum process of Icraiin be hydrolyzed to Baohuoside I by cellulase was intuitively analyzed by 3D surface chart, and taking verification tests and predictive analysis. The best enzymatic hydrolytic process was as following: substrate concentration 8. 23 mg/mL, pH 5. 12 of buffer,reaction time 35. 34 h. The optimum process of Icraiin be hydrolyzed to Baohuoside I by cellulase is determined by Plackett-Burman design combined with CCD response surface methodology. The optimized enzymatic hydrolytic process is simple, convenient, accurate, reproducible and predictable.

  10. Novel Manufacturing Process for Unique Mixed Carbide Refractory Composites, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — This STTR Phase I project will establish the feasibility of an innovative manufacturing process to fabricate a range of unique hafnium/silicon based carbide...

  11. (DARPA) Topologically Protected Quantum Information Processing In Spin-Orbit Compled Semiconductors

    Science.gov (United States)

    2013-12-17

    expression for the disorder suppression of the superconducting quasiparticle gap in the topological superconducting states carrying MFs. Our principle...assisted electron transfer amplitude (derived from the fractionalization property of the MFs) the quasiparticle tunneling from to through the...mesoscopic rings, the energy-level of such a quasiparticle excitation spectrum in the ring is expected to develop a periodic dependence on

  12. Pickling process of capers (<i>Capparis spp.i> flower buds

    Directory of Open Access Journals (Sweden)

    Özcan, Musa

    1999-04-01

    Full Text Available Middle sized (8 < x < 13 mm buds of <i>Capparis spinosai> var. <i>spinosa> and C. <i>ovata> var. <i>canescens> from June in brines containing 5,10,15 and 20% salt and from August in brines of 15% salt, and three different size (x < 8 mm, 8 < x < 13 mm, x > 13 mm buds of C. . <i>ovata> var. <i>canescens> from June in brines of 15% salt were pickled for two months fermentation. Some chemical and microbiological analyses were done in brines during fermentation. Most suitable salt concentration for lactic acid bacteria (LAB activity were 5% and partly 10%. Acidity, LAB activity, sedimentation and hardness were reduced by increasing bud size in C. <i>ovata>. Small buds of C. <i>ovata> for pickling product had advantage for colour and flavour, however, more sediment and partly softening showed disadvantage. For both species, pickling time was determined as 40 to 50 days in regard of end-product flavour and odour, brine acidity and pH, and LAB activity.

    Se encurtieron durante dos meses botones florales de tamaño medio (8 < x < 13 mm de <i>Capparis spinosai
    > var. <i>spinosa> y C. <i>ovata> var. <i>canescens>, los recolectados en Junio en salmueras conteniendo 5, 10, 15 y 20% de sal, y los de Agosto en salmueras de 15% de sal; y tres tamaños diferentes (x < 8 mm, 8 < x < 13 mm, X > 13 mm de C. <i>ovata> var. <i>canescens> de Junio en salmueras de 15% de sal. Se realizaron algunos análisis químicos y microbiológicos durante la fermentación. Las concentraciones de sal más adecuadas para la actividad de las bacterias del ácido láctico (LAB fueron 5% y parcialmente 10%. Acidez, actividad de LAB, sedimentación y firmeza (hardness se redujeron al incrementar el tamaño de las alcaparras de C. <i>ovata>. Los tamaños pequeños de C. <i>ovata> presentaron en el producto encurtido ventajas en color y sabor, pero desventajas por más sedimento y ablandamiento parcial. El tiempo de encurtido para ambas

  13. MMX-I: data-processing software for multimodal X-ray imaging and tomography

    Energy Technology Data Exchange (ETDEWEB)

    Bergamaschi, Antoine, E-mail: antoine.bergamaschi@synchrotron-soleil.fr; Medjoubi, Kadda [Synchrotron SOLEIL, BP 48, Saint-Aubin, 91192 Gif sur Yvette (France); Messaoudi, Cédric; Marco, Sergio [Université Paris-Saclay, CNRS, Université Paris-Saclay, F-91405 Orsay (France); Institut Curie, INSERM, PSL Reseach University, F-91405 Orsay (France); Somogyi, Andrea [Synchrotron SOLEIL, BP 48, Saint-Aubin, 91192 Gif sur Yvette (France)

    2016-04-12

    The MMX-I open-source software has been developed for processing and reconstruction of large multimodal X-ray imaging and tomography datasets. The recent version of MMX-I is optimized for scanning X-ray fluorescence, phase-, absorption- and dark-field contrast techniques. This, together with its implementation in Java, makes MMX-I a versatile and friendly user tool for X-ray imaging. A new multi-platform freeware has been developed for the processing and reconstruction of scanning multi-technique X-ray imaging and tomography datasets. The software platform aims to treat different scanning imaging techniques: X-ray fluorescence, phase, absorption and dark field and any of their combinations, thus providing an easy-to-use data processing tool for the X-ray imaging user community. A dedicated data input stream copes with the input and management of large datasets (several hundred GB) collected during a typical multi-technique fast scan at the Nanoscopium beamline and even on a standard PC. To the authors’ knowledge, this is the first software tool that aims at treating all of the modalities of scanning multi-technique imaging and tomography experiments.

  14. I12: the Joint Engineering, Environment and Processing (JEEP) beamline at Diamond Light Source.

    Science.gov (United States)

    Drakopoulos, Michael; Connolley, Thomas; Reinhard, Christina; Atwood, Robert; Magdysyuk, Oxana; Vo, Nghia; Hart, Michael; Connor, Leigh; Humphreys, Bob; Howell, George; Davies, Steve; Hill, Tim; Wilkin, Guy; Pedersen, Ulrik; Foster, Andrew; De Maio, Nicoletta; Basham, Mark; Yuan, Fajin; Wanelik, Kaz

    2015-05-01

    I12 is the Joint Engineering, Environmental and Processing (JEEP) beamline, constructed during Phase II of the Diamond Light Source. I12 is located on a short (5 m) straight section of the Diamond storage ring and uses a 4.2 T superconducting wiggler to provide polychromatic and monochromatic X-rays in the energy range 50-150 keV. The beam energy enables good penetration through large or dense samples, combined with a large beam size (1 mrad horizontally × 0.3 mrad vertically). The beam characteristics permit the study of materials and processes inside environmental chambers without unacceptable attenuation of the beam and without the need to use sample sizes which are atypically small for the process under study. X-ray techniques available to users are radiography, tomography, energy-dispersive diffraction, monochromatic and white-beam two-dimensional diffraction/scattering and small-angle X-ray scattering. Since commencing operations in November 2009, I12 has established a broad user community in materials science and processing, chemical processing, biomedical engineering, civil engineering, environmental science, palaeontology and physics.

  15. Validation of HVOF Thermal Spray Coatings as a Replacement for Hard Chrome Plating on Hydraulic/Pneumatic Actuators

    Science.gov (United States)

    2007-12-01

    Projects Agency (DARPA). The program evaluated HVOF, physical vapor deposition (PVD) and laser cladding , and concluded that HVOF was the best overall...components such as titanium flap tracks. 5 2.0 TECHNOLOGY DESCRIPTION 2.1 TECHNOLOGY DEVELOPMENT AND APPLICATION Technology background and...theory of operation: High-velocity oxygen-fuel (HVOF) is a standard commercial thermal spray process in which a powder of the material to be sprayed

  16. Bio-mechanical assessment toward throwing and lifting process of i-LOCA (Innovative Lobster Catcher)

    Science.gov (United States)

    Sudiarno, A.; Dewi, D. S.; Putri, M. A.

    2018-04-01

    Indonesia is the country rich in marine resource, one of which is lobster. East java, one of Indonesian province, especially in Region of Gresik and Lamogan, has very huge potential of lobster. Current condition shown that lobster catch by the fisherman mostly depend on lucky factor, which the lobster unintentionally trapped in fisherman’s fish net. By using this mechanism, the number of lobster catch cannot be optimum. Previous researches have produced two versions of i-LOCA, Innovative Lobster Catcher, a special tool for catching the lobster. Although produce more lobster catch, second version of i-LOCA still needs to be scrutinized, one of that is bio-mechanical assessment. The second version of i-LOCA still has no tool to ease throwing and lifting it into the sea. This condition cause Musculoskeletal Disorder (MSD) toward the fisherman. This research perform bio-mechanical assessment toward throwing and lifting process in order to suggest improvement for i-LOCA as the third version. Based on body moment calculation, we found that throwing and lifting process of third version of i-LOCA, each was 3 times and 2 times better than second version of i-LOCA. Meanwhile, Rapid Entire Body Assessment (REBA) score of throwing and lifting process for third version of i-LOCA can be reduced by 5 points compared to second version of i-LOCA.

  17. The MIT Lincoln Laboratory RT-04F Diarization Systems: Applications to Broadcast Audio and Telephone Conversations

    Science.gov (United States)

    2004-11-01

    this paper we describe the systems developed by MITLL and used in DARPA EARS Rich Transcription Fall 2004 (RT-04F) speaker diarization evaluation...many types of audio sources, the focus if the DARPA EARS project and the NIST Rich Transcription evaluations is primarily speaker diarization ...present or samples of any of the speakers . An overview of the general diarization problem and approaches can be found in [1]. In this paper, we

  18. 'I want to be a TV historian when I grow up!': On Being a Rewind Historian

    Directory of Open Access Journals (Sweden)

    Michelle Arrow

    2006-03-01

    Full Text Available In 2004, I worked as a presenter on a new ABC TV program called Rewind. Produced as part of a special initiative to make programs about Australian history, Rewind used several historians as presenters and promised to tell new stories from Australia’s past. Few historians experience the production processes of television in such a detailed way: the media and the academy are arguably a little suspicious of each other. The experience of working on Rewind was an extraordinary one – both exhilarating and frustrating. In this article, I draw on this experience to explore some of the issues that one faces as a ‘television historian’. How much control were we able to exert over our role and presence in the storytelling process? How were we used in the program and marketed in its publicity? The article also explore the qualities of television history itself: what are its flaws and virtues? How is it different from written history? It examines recent history on television to consider the media context in which Rewind was made and received. Finally, the article considers the role of historians in the making of Rewind and examines audience perceptions and responses to the program.

  19. 'When I get better I will do the test': Facilitators and barriers to HIV ...

    African Journals Online (AJOL)

    'When I get better I will do the test': Facilitators and barriers to HIV testing in Northwest Region of Cameroon with implications for TB and HIV/AIDS control ... However, as a result of conflicting emotional experiences regarding to test or not to test, the decision-making process was not straightforward and this complex process ...

  20. Breast Malignant Processes Echography at V. I. Lenin Hospital

    International Nuclear Information System (INIS)

    Tamayo Hernandez, Lissette; Aguilar Munnoz, Liliana; Estevez de la Torre, Elyanne; Ricardo Guerrero, Migdania; Rodriguez Infanzon, Olga; Hung Arroyo, Jose Manuel

    2007-01-01

    A descriptive and cross-sectional study was carried out in patients with a presumptive diagnosis of breast malignant processes . The patients came from the breast cancer consulting room at V. I. Lenin Hospital from January 2005 to December 2005. A breast ultrasound imaging was done aimed at deepening in the diagnosis which was predominant in pre- menopausal women , being the left breast external upper quadrant the most frequent site of localization. The most suggestive echography pattern of malignant processes was the image with changes in its echostructure, soft echos in its inner part and irregular edge were observed. According to the mammography results the most frequent presentation was the visualization of a thick breast of irregular edge with spicule formations. There was a diagnostic correspondence between the echogram and the mammography considering that this is an adequate method for the initial evaluation of breast malignant processes

  1. California Food Processing Industry Wastewater Demonstration Project: Phase I Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Lewis, Glen; Atkinson, Barbara; Rhyne, Ivin

    2009-09-09

    Wastewater treatment is an energy-intensive process and electricity demand is especially high during the utilities summer peak electricity demand periods. This makes wastewater treatment facilities prime candidates for demand response programs. However, wastewater treatment is often peripheral to food processing operations and its demand response opportunities have often been overlooked. Phase I of this wastewater demonstration project monitored wastewater energy and environmental data at Bell-Carter Foods, Inc., California's largest olive processing plant. For this monitoring activity the project team used Green Energy Management System (GEMS) automated enterprise energy management (EEM) technologies. This report presents results from data collected by GEMS from September 15, 2008 through November 30, 2008, during the olive harvest season. This project established and tested a methodology for (1) gathering baseline energy and environmental data at an industrial food-processing plant and (2) using the data to analyze energy efficiency, demand response, daily peak load management, and environmental management opportunities at the plant. The Phase I goals were to demonstrate the measurement and interrelationship of electricity demand, electricity usage, and water quality metrics and to estimate the associated CO{sub 2} emissions.

  2. ER stress affects processing of MHC class I-associated peptides

    Directory of Open Access Journals (Sweden)

    Meloche Sylvain

    2009-02-01

    Full Text Available Abstract Background Viral infection and neoplastic transformation trigger endoplasmic reticulum (ER stress. Thus, a large proportion of the cells that must be recognized by the immune system are stressed cells. Cells respond to ER stress by launching the unfolded protein response (UPR. The UPR regulates the two key processes that control major histocompatibility complex class I (MHC I-peptide presentation: protein synthesis and degradation. We therefore asked whether and how the UPR impinges on MHC I-peptide presentation. Results We evaluated the impact of the UPR on global MHC I expression and on presentation of the H2Kb-associated SIINFEKL peptide. EL4 cells stably transfected with vectors coding hen egg lysozyme (HEL-SIINFEKL protein variants were stressed with palmitate or exposed to glucose deprivation. UPR decreased surface expression of MHC I but did not affect MHC I mRNA level nor the total amount of intracellular MHC I proteins. Impaired MHC I-peptide presentation was due mainly to reduced supply of peptides owing to an inhibition of overall protein synthesis. Consequently, generation of H2Kb-SIINFEKL complexes was curtailed during ER stress, illustrating how generation of MHC I peptide ligands is tightly coupled to ongoing protein synthesis. Notably, the UPR-induced decline of MHC I-peptide presentation was more severe when the protein source of peptides was localized in the cytosol than in the ER. This difference was not due to changes in the translation rates of the precursor proteins but to increased stability of the cytosolic protein during ER stress. Conclusion Our results demonstrate that ER stress impairs MHC I-peptide presentation, and that it differentially regulates expression of ER- vs. cytosol-derived peptides. Furthermore, this work illustrates how ER stress, a typical feature of infected and malignant cells, can impinge on cues for adaptive immune recognition.

  3. Online interferometric study of viscoelastic rupture and necking deformation of as-spun (iPP) fibres due to creep process.

    Science.gov (United States)

    Sokkar, Taha; El-Farahaty, Kermal; Azzam, Amira

    2015-01-01

    Creep deformation under constant load leads to rupture when the polymer chains can no longer separate and accommodate the load. This fracture phenomenon is investigated interferometrically. The creep behaviour of as-spun isotactic Polypropylene (iPP) fibres is studied at different stresses, different initial lengths and different radii. The creep rate, which defines the velocity of the creep deformation and the dimensional stability of the material, is studied. The failure time and stress of iPP due to creep process is determined. The necking deformation was in situ detected during creep process. The mean refractive indices (n(P) andn⊥) profiles of iPP fibres were determined at different positions along the fibre axis before and after necking. The relation between the creep behaviour and different optical and structural parameters is investigated. Microinterferograms are given for illustration. © 2015 The Authors Journal of Microscopy © 2015 Royal Microscopical Society.

  4. The iFlow modelling framework v2.4: a modular idealized process-based model for flow and transport in estuaries

    Science.gov (United States)

    Dijkstra, Yoeri M.; Brouwer, Ronald L.; Schuttelaars, Henk M.; Schramkowski, George P.

    2017-07-01

    The iFlow modelling framework is a width-averaged model for the systematic analysis of the water motion and sediment transport processes in estuaries and tidal rivers. The distinctive solution method, a mathematical perturbation method, used in the model allows for identification of the effect of individual physical processes on the water motion and sediment transport and study of the sensitivity of these processes to model parameters. This distinction between processes provides a unique tool for interpreting and explaining hydrodynamic interactions and sediment trapping. iFlow also includes a large number of options to configure the model geometry and multiple choices of turbulence and salinity models. Additionally, the model contains auxiliary components, including one that facilitates easy and fast sensitivity studies. iFlow has a modular structure, which makes it easy to include, exclude or change individual model components, called modules. Depending on the required functionality for the application at hand, modules can be selected to construct anything from very simple quasi-linear models to rather complex models involving multiple non-linear interactions. This way, the model complexity can be adjusted to the application. Once the modules containing the required functionality are selected, the underlying model structure automatically ensures modules are called in the correct order. The model inserts iteration loops over groups of modules that are mutually dependent. iFlow also ensures a smooth coupling of modules using analytical and numerical solution methods. This way the model combines the speed and accuracy of analytical solutions with the versatility of numerical solution methods. In this paper we present the modular structure, solution method and two examples of the use of iFlow. In the examples we present two case studies, of the Yangtze and Scheldt rivers, demonstrating how iFlow facilitates the analysis of model results, the understanding of the

  5. Air-to-Air UAV Aerial Refueling

    Data.gov (United States)

    National Aeronautics and Space Administration — Armstrong researchers, in cooperation with Northrop Grumman Corporation and the Defense Advanced Research Projects Agency (DARPA) demonstrated autonomous aerial...

  6. Defense Small Business Innovation Research Program (SBIR). Volume 4. Defense Agencies Abstracts of Phase 1 Awards. 1990

    Science.gov (United States)

    1990-01-01

    RI 02871 Program Manager: T. DEEGAN Contract #: Title: LF DETECTION OF AIRCRAFT Topic #: DARPA90-049 Office: ID #: 50506 TECHNICAL ABSTRACT - COMBAT...INNOVATION RESEARCH PROGRAM - PHASE I SDIO Solicitation 90.1 TORRANCE, CA 90505 Program Manager: JAMES E CRAIG Contract #: Title: NONINTRUSIVE OPTICAL

  7. Engineered Alloy Structures by Friction Stir Reaction Processing, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — This SBIR Phase I effort examines the feasibility of an innovative surface modification technology incorporating friction stir reaction processing for producing...

  8. Development of a recovery method of 131I in the 99Mo process through the fission of 235U

    International Nuclear Information System (INIS)

    Bignardi, Aline Moraes Teixeira

    2013-01-01

    13 1 I is an iodine radioisotope widely used in nuclear medicine that can be used either for diagnostic or for treatment due to its physical decay by β - and its high emission of y-rays. It is produced at IPEN using the indirect reaction: 130 Te(n,y) 131m Te → 131 Te → 131 I where TeO 2 targets are irradiated in a Nuclear Reactor. There is also the possibility of producing 131 I by the fission of 235 U, where about 300 different elements are produced together with 131 I. The 131 I produced through this method presents high specific activity and radioactive concentration suitable for the labeling of molecules. The aim of this work was to develop a recovery method of 131 I with the required quality to be used in Nuclear Medicine in the 99 Mo production process through the route of acid dissolution of metallic 235 U targets. 131 I can appear in two phases of the process, both in the gaseous phase produced during the dissolution of metallic U targets and in the dissolution solution. This work studied the recovery of 131 I in these two phases. Several materials were used for the capture and recovery of 131 I at the two phases of the process, the gaseous one and the solution of dissolution of U targets. Columns of alumina with Cu, acid alumina with Cu, Ag microspheres, Cu microspheres, Ag nanospheres, anionic cartridges, Ag cartridges, anion exchange resin and activated charcoal columns were tested. Solutions containing 131 I in 0.1 mol.L -1 NaOH were percolated through the materials and the eluted solutions were analyzed in a dose calibrator. The precipitation of AgI was also studied wth further dissolution of this precipitate with 0.1 mol L -1 NH 4 OH and 5% Na 2 S 2 O 3 . The recovery results varied according to the material, activated charcoal showed recovery yields between 42% and 83% but the recovery yield of the alumina column with Cu ranged from 20% to 85%. Tests with Ag nanospheres showed recovery yield of 26% using 0.1 mol L -1 NaOH and 72% for Na 2 S 2 O

  9. Using a profiling process to insure program quality: Volume I - a self-instructional manual

    Energy Technology Data Exchange (ETDEWEB)

    Kaser, J.S.; Roody, D.S.; Raizen, S.A.

    1996-11-01

    Between 1990 and 1995 the U.S. Department of Energy (DOE) and the National Center for Improving Science Education (National Center) developed a system for ongoing evaluation of K-12 educational programs in the DOE-supported national energy Laboratories. As part of the formative evaluation component of this collaborative endeavor, field staff in the Laboratories began creating profiles of their programs. However, many individuals within DOE Headquarters were not familiar with this profiling process and were unprepared to use the valuable information that the profiles generated. This manual was produced to orient Headquarters staff to profiling. It focuses on how Headquarters staff can use the profiling process to help their funded programs establish and/or maintain high quality. Its purpose, then, is not to train Headquarters staff to become proficient in profiling, but to show them how to draw on the Laboratories` use of profiling to bring about program improvement. Profiling is the process of systematically examining and describing a program`s elements against a set of components that define Effective Practice. The instrument used to capture the data for analysis is called a template, and most of this manual focuses on the templates and how to read and interpret them. However, since it is important to understand these data in context, the authors also describe what should accompany each template in a complete profiling packet and offer guidelines for reviewing complete packets and providing feedback to program managers.

  10. Structural Metadata Research in the Ears Program

    National Research Council Canada - National Science Library

    Liu, Yang; Shriberg, Elizabeth; Stolcke, Andreas; Peskin, Barbara; Ang, Jeremy; Hillard, Dustin; Ostendorf, Mari; Tomalin, Marcus; Woodland, Phil; Harper, Mary

    2005-01-01

    Both human and automatic processing of speech require recognition of more than just words. In this paper we provide a brief overview of research on structural metadata extraction in the DARPA EARS rich transcription program...

  11. Wavelets and their applications past and future

    Science.gov (United States)

    Coifman, Ronald R.

    2009-04-01

    As this is a conference on mathematical tools for defense, I would like to dedicate this talk to the memory of Louis Auslander, who through his insights and visionary leadership, brought powerful new mathematics into DARPA, he has provided the main impetus to the development and insertion of wavelet based processing in defense. My goal here is to describe the evolution of a stream of ideas in Harmonic Analysis, ideas which in the past have been mostly applied for the analysis and extraction of information from physical data, and which now are increasingly applied to organize and extract information and knowledge from any set of digital documents, from text to music to questionnaires. This form of signal processing on digital data, is part of the future of wavelet analysis.

  12. Lightening the Load of a USMC Rifle Platoon Through Robotics Integration

    Science.gov (United States)

    2014-06-01

    Boston Dynamics (from Knowles, 2013) 12 Another robot under the M3 development program at DARPA is the Cheetah robot. The Cheetah robot looks nearly...untethered and free-standing in comparison to its predecessor the Cheetah . DARPA is still conducting outdoor testing on the WildCat, but this free...running version of the Cheetah can run up to 16 mph and is expected to eventually gain speed up to 50 mph and still be capable to do so over different

  13. Feasibility and advantages of commercial process I/O systems for accelerator control

    International Nuclear Information System (INIS)

    Belshe, R.A.; Elischer, V.P.; Jacobson, V.

    1975-03-01

    Control systems for large particle accelerators must be able to handle analog and digital signals and timing coordination for devices which are spread over a large physical area. Many signals must be converted and transmitted to and from a central control area during each accelerator cycle. Digital transmission is often used to combat common mode and RF interference. Most accelerators in use today have met these requirements with custom process I/O hardware, data transmission systems, and computer interfaces. In-house development of hardware and software has been a very costly and time consuming process, but due to the lack of available commercial equipment, there was often no other alternative. Today, a large portion of these development costs can be avoided. Small control computers are now available off the shelf which have extensive process control I/O hardware and software capability. Computer control should be designed into accelerator systems from the beginning, using operating systems available from manufacturer. With most of the systems programming done, the designers can begin immediately on the applications software. (U.S.)

  14. Cyber security consideration on I and C system development process

    International Nuclear Information System (INIS)

    Park, Jaek Wan; Park, Jeyun; Kim, Young Ki

    2012-01-01

    Instrumentation and control (I and C) systems in nuclear power plants collect sensor signals installed in plant fields, monitor plant performance and status, and generate signals to control instruments for plant operation and protection. Recently, digital systems of I and C are required to be protected from cyber threats. It has been reported that several plants have been attacked and malfunctioned by outside intruders. To cope with cyber attacks, various studies have been proposed in IT and plant industries. From 2006, regulatory guides and industry standards for cyber security have been published. Therefore, these guides should be strongly considered in the development process of a digital system. Our framework refers to the system development life cycle described in RG 1.152. The main activities of RG 5.71 are included in the framework appropriately. This approach supports the consistent application of system features for cyber security by incorporating the security requirements required in the operation and maintenance phases into the initial phase of development process. It is expected that the application of the framework to a new plant system design may comply with both RG 1.152 and 5.71

  15. Cyber security consideration on I and C system development process

    Energy Technology Data Exchange (ETDEWEB)

    Park, Jaek Wan; Park, Jeyun; Kim, Young Ki [KAERI, Daejeon (Korea, Republic of)

    2012-10-15

    Instrumentation and control (I and C) systems in nuclear power plants collect sensor signals installed in plant fields, monitor plant performance and status, and generate signals to control instruments for plant operation and protection. Recently, digital systems of I and C are required to be protected from cyber threats. It has been reported that several plants have been attacked and malfunctioned by outside intruders. To cope with cyber attacks, various studies have been proposed in IT and plant industries. From 2006, regulatory guides and industry standards for cyber security have been published. Therefore, these guides should be strongly considered in the development process of a digital system. Our framework refers to the system development life cycle described in RG 1.152. The main activities of RG 5.71 are included in the framework appropriately. This approach supports the consistent application of system features for cyber security by incorporating the security requirements required in the operation and maintenance phases into the initial phase of development process. It is expected that the application of the framework to a new plant system design may comply with both RG 1.152 and 5.71.

  16. Detailed conformation dynamics and activation process of wild type c-Abl and T315I mutant

    Science.gov (United States)

    Yang, Li-Jun; Zhao, Wen-Hua; Liu, Qian

    2014-10-01

    Bcr-Abl is an important target for therapy against chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL). The synergistic effect between myristyl pocket and the ATP pocket has been found. But its detailed information based on molecular level still has not been achieved. In this study, conventional molecular dynamics (CMD) and target molecular dynamics (TMD) simulations were performed to explore the effect of T315I mutation on dynamics and activation process of Abl containing the N-terminal cap (Ncap). The CMD simulation results reveal the increasing flexibility of ATP pocket in kinase domain (KD) after T315I mutation which confirms the disability of ATP-pocket inhibitors to the Abl-T315I mutant. On the contrary, the T315I mutation decreased the flexibility of remote helix αI which suggests the synergistic effect between them. The mobility of farther regions containing Ncap, SH3, SH2 and SH2-KD linker were not affected by T315I mutation. The TMD simulation results show that the activation process of wild type Abl and Abl-T315I mutant experienced global conformation change. Their differences were elucidated by the activation motion of subsegments including A-loop, P-loop and Ncap. Besides, the T315I mutation caused decreasing energy barrier and increasing intermediate number in activation process, which results easier activation process. The TMD and CMD results indicate that a drug targeting only the ATP pocket is not enough to inhibit the Abl-T315I mutant. An effective way to inhibit the abnormal activity of Abl-T315I mutant is to combine the ATP-pocket inhibitors with inhibitors binding at non-ATP pockets mainly related to Ncap, SH2-KD linker and myristyl pocket.

  17. Blind I/Q Signal Separation-Based Solutions for Receiver Signal Processing

    Directory of Open Access Journals (Sweden)

    Visa Koivunen

    2005-09-01

    Full Text Available This paper introduces some novel digital signal processing (DSP-based approaches to some of the most fundamental tasks of radio receivers, namely, channel equalization, carrier synchronization, and I/Q mismatch compensation. The leading principle is to show that all these problems can be solved blindly (i.e., without training signals by forcing the I and Q components of the observed data as independent as possible. Blind signal separation (BSS is then introduced as an efficient tool to carry out these tasks, and simulation examples are used to illustrate the performance of the proposed approaches. The main application area of the presented carrier synchronization and I/Q mismatch compensation techniques is in direct-conversion type receivers, while the proposed channel equalization principles basically apply to any radio architecture.

  18. The iFlow modelling framework v2.4: a modular idealized process-based model for flow and transport in estuaries

    Directory of Open Access Journals (Sweden)

    Y. M. Dijkstra

    2017-07-01

    Full Text Available The iFlow modelling framework is a width-averaged model for the systematic analysis of the water motion and sediment transport processes in estuaries and tidal rivers. The distinctive solution method, a mathematical perturbation method, used in the model allows for identification of the effect of individual physical processes on the water motion and sediment transport and study of the sensitivity of these processes to model parameters. This distinction between processes provides a unique tool for interpreting and explaining hydrodynamic interactions and sediment trapping. iFlow also includes a large number of options to configure the model geometry and multiple choices of turbulence and salinity models. Additionally, the model contains auxiliary components, including one that facilitates easy and fast sensitivity studies. iFlow has a modular structure, which makes it easy to include, exclude or change individual model components, called modules. Depending on the required functionality for the application at hand, modules can be selected to construct anything from very simple quasi-linear models to rather complex models involving multiple non-linear interactions. This way, the model complexity can be adjusted to the application. Once the modules containing the required functionality are selected, the underlying model structure automatically ensures modules are called in the correct order. The model inserts iteration loops over groups of modules that are mutually dependent. iFlow also ensures a smooth coupling of modules using analytical and numerical solution methods. This way the model combines the speed and accuracy of analytical solutions with the versatility of numerical solution methods. In this paper we present the modular structure, solution method and two examples of the use of iFlow. In the examples we present two case studies, of the Yangtze and Scheldt rivers, demonstrating how iFlow facilitates the analysis of model results, the

  19. Understanding cognitive processes behind acceptance or refusal of phase I trials.

    Science.gov (United States)

    Pravettoni, Gabriella; Mazzocco, Ketti; Gorini, Alessandra; Curigliano, Giuseppe

    2016-04-01

    Participation in phase I trials gives patients the chance to obtain control over their disease by trying an experimental therapy. The patients' vulnerability, the informed consent process aiming at understanding the purpose and potential benefits of the phase I trial, and the complexity of the studies may impact the patient's final decision. Emotionally difficult health conditions may induce patients to succumb to cognitive biases, allocating attention only on a part of the provided information. Filling the gap in patients' information process can foster the implementation of strategies to help physicians tailor clinical trials' communication providing personalized support and tailored medical information around patients' need, so avoiding cognitive biases in patients and improving informed shared decision quality. The aim of the present review article focuses on the analysis of cognitive and psychological factors that affect patients' decision to participate or not to early phase clinical trials. Copyright © 2016. Published by Elsevier Ireland Ltd.

  20. I12: the Joint Engineering, Environment and Processing (JEEP) beamline at Diamond Light Source

    International Nuclear Information System (INIS)

    Drakopoulos, Michael; Connolley, Thomas; Reinhard, Christina; Atwood, Robert; Magdysyuk, Oxana; Vo, Nghia; Hart, Michael; Connor, Leigh; Humphreys, Bob; Howell, George; Davies, Steve; Hill, Tim; Wilkin, Guy; Pedersen, Ulrik; Foster, Andrew; De Maio, Nicoletta; Basham, Mark; Yuan, Fajin; Wanelik, Kaz

    2015-01-01

    JEEP is a high-energy (50–150 keV) multi-purpose beamline offering polychromatic and monochromatic modes. It can accommodate large samples and experimental rigs, enabling in situ studies using radiography, tomography, energy-dispersive diffraction, monochromatic and white-beam two-dimensional diffraction/scattering and small-angle X-ray scattering. I12 is the Joint Engineering, Environmental and Processing (JEEP) beamline, constructed during Phase II of the Diamond Light Source. I12 is located on a short (5 m) straight section of the Diamond storage ring and uses a 4.2 T superconducting wiggler to provide polychromatic and monochromatic X-rays in the energy range 50–150 keV. The beam energy enables good penetration through large or dense samples, combined with a large beam size (1 mrad horizontally × 0.3 mrad vertically). The beam characteristics permit the study of materials and processes inside environmental chambers without unacceptable attenuation of the beam and without the need to use sample sizes which are atypically small for the process under study. X-ray techniques available to users are radiography, tomography, energy-dispersive diffraction, monochromatic and white-beam two-dimensional diffraction/scattering and small-angle X-ray scattering. Since commencing operations in November 2009, I12 has established a broad user community in materials science and processing, chemical processing, biomedical engineering, civil engineering, environmental science, palaeontology and physics

  1. Hybrid perovskite solar cells: In situ investigation of solution-processed PbI2 reveals metastable precursors and a pathway to producing porous thin films

    KAUST Repository

    Barrit, Dounya; Sheikh, Arif D.; Munir, Rahim; Barbe, Jeremy; Li, Ruipeng; Smilgies, Detlef-M.; Amassian, Aram

    2017-01-01

    from a DMF solution by performing in situ grazing incidence wide angle X-ray scattering (GIWAXS) measurements. The measurements reveal an elaborate sol–gel process involving three PbI2⋅DMF solvate complexes—including disordered and ordered ones

  2. The process of recovery from bipolar I disorder: a qualitative analysis of personal accounts in relation to an integrative cognitive model.

    Science.gov (United States)

    Mansell, Warren; Powell, Seth; Pedley, Rebecca; Thomas, Nia; Jones, Sarah Amelia

    2010-06-01

    This study explored the process of recovery from bipolar I disorder from a phenomenological and cognitive perspective. A semi-structured interview was coded and analysed using interpretative phenomenological analysis. Eleven individuals over the age of 30 with a history of bipolar disorder were selected on the basis of having remained free from relapse, and without hospitalization for at least 2 years, as confirmed by a diagnostic interview (Standardised Interview for DSM-IV; SCID-I). This arbitrary and equivocal criterion for 'recovery' provided an objective method of defining the sample for the study. The analysis revealed two overarching themes formed from four themes each. Ambivalent approaches referred to approaches that participants felt had both positive and negative consequences: avoidance of mania, taking medication, prior illness versus current wellness, and sense of identity following diagnosis. Helpful approaches referred to approaches that were seen as universally helpful: understanding, life-style fundamentals, social support and companionship, and social change. These themes were then interpreted in the light of the existing literature and an integrative cognitive model of bipolar disorder. Limitations and future research directions are discussed.

  3. 21 CFR 212.60 - What requirements apply to the laboratories where I test components, in-process materials, and...

    Science.gov (United States)

    2010-04-01

    ... maintenance. Each laboratory must have and follow written procedures to ensure that equipment is routinely... 21 Food and Drugs 4 2010-04-01 2010-04-01 false What requirements apply to the laboratories where...) Laboratory Controls § 212.60 What requirements apply to the laboratories where I test components, in-process...

  4. 14 CFR 11.39 - How may I participate in FAA's rulemaking process?

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false How may I participate in FAA's rulemaking process? 11.39 Section 11.39 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF... participate in FAA's rulemaking process? You may participate in FAA's rulemaking process by doing any of the...

  5. Extending the 4I Organizational Learning Model: Information Sources, Foraging Processes and Tools

    Directory of Open Access Journals (Sweden)

    Tracy A. Jenkin

    2013-08-01

    Full Text Available The continued importance of organizational learning has recently led to several calls for further developing the theory. This article addresses these calls by extending Crossan, Lane and White’s (1999 4I model to include a fifth process, information foraging, and a fourth level, the tool. The resulting 5I organizational learning model can be generalized to a number of learning contexts, especially those that involve understanding and making sense of data and information. Given the need for organizations to both innovate and increase productivity, and the volumes of data and information that are available to support both, the 5I model addresses an important organizational issue.

  6. A-to-I RNA editing: the "ADAR" side of human cancer.

    Science.gov (United States)

    Galeano, Federica; Tomaselli, Sara; Locatelli, Franco; Gallo, Angela

    2012-05-01

    Carcinogenesis is a complex, multi-stage process depending on both endogenous and exogenous factors. In the past years, DNA mutations provided important clues to the comprehension of the molecular pathways involved in numerous cancers. Recently, post-transcriptional modification events, such as RNA editing, are emerging as new players in several human diseases, including tumours. A-to-I RNA editing changes the nucleotide sequence of target RNAs, introducing A-to-I/G "mutations". Since ADAR enzymes catalyse this nucleotide conversion, their expression/activity is essential and finely regulated in normal cells. This review summarizes the available knowledge on A-to-I RNA editing in the cancer field, giving a new view on how ADARs may play a role in carcinogenesis. Copyright © 2011 Elsevier Ltd. All rights reserved.

  7. Micro-Channel Reactor for Processing Carbon Dioxide to Ethylene, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — The processing of carbon dioxide is a continuing NASA need, ranging from separation processes to remove it from cabin air, to reaction processes that convert the...

  8. Flank wear and I-kaz 3D correlation in ball end milling process of Inconel 718

    Directory of Open Access Journals (Sweden)

    M.A.S.M. Tahir

    2015-12-01

    Full Text Available Tool wear may deteriorate the machine product quality due to high surface roughness, dimension exceeding tolerance and also to machine tool itself. Tool wear monitoring system is vital to be used in machining process to achieve high quality of the machined product and at the same time improve the productivity. Nowadays, many monitoring system developed using various sensor and statistical technique to analyze the signals being used. In this paper, I-kaz 3D method is used to analyze cutting force signal in milling process of Inconel 718 for monitoring the status of tool wear in milling process. The results from analyzing cutting force show that I-kaz 3D coefficient has a correlation with cutting tool condition. Tool wear will generate high value of I-kaz 3D coefficient than the sharp cutting tool. Furthermore, the three dimension graphical representation of I-kaz 3D for all cutting condition shown that the degree of scattering data increases with tool wear progression.

  9. A methodology for fault diagnosis in large chemical processes and an application to a multistage flash desalination process: Part I

    International Nuclear Information System (INIS)

    Tarifa, Enrique E.; Scenna, Nicolas J.

    1998-01-01

    This work presents a new strategy for fault diagnosis in large chemical processes (E.E. Tarifa, Fault diagnosis in complex chemistries plants: plants of large dimensions and batch processes. Ph.D. thesis, Universidad Nacional del Litoral, Santa Fe, 1995). A special decomposition of the plant is made in sectors. Afterwards each sector is studied independently. These steps are carried out in the off-line mode. They produced vital information for the diagnosis system. This system works in the on-line mode and is based on a two-tier strategy. When a fault is produced, the upper level identifies the faulty sector. Then, the lower level carries out an in-depth study that focuses only on the critical sectors to identify the fault. The loss of information produced by the process partition may cause spurious diagnosis. This problem is overcome at the second level using qualitative simulation and fuzzy logic. In the second part of this work, the new methodology is tested to evaluate its performance in practical cases. A multiple stage flash desalination system (MSF) is chosen because it is a complex system, with many recycles and variables to be supervised. The steps for the knowledge base generation and all the blocks included in the diagnosis system are analyzed. Evaluation of the diagnosis performance is carried out using a rigorous dynamic simulator

  10. Mobile ultrasound plane wave beamforming on iPhone or iPad using metal-based GPU processing

    OpenAIRE

    Hewener, H.; Tretbar, S.

    2015-01-01

    Mobile and cost effective ultrasound devices are being used in point of care scenarios or the drama room. To reduce the costs of such devices we already presented the possibilities of consumer devices like Apple iPad for full signal processing of raw data for ultraound image generation. Using technologies like plane wave imaging to generate a full image with only one excitation/reception event the acquisition times and power consumption of ultrasound imaging can be reduced for low power mobil...

  11. The NIHR Invention for Innovation (i4i) Programme: A Review of Progress and Contributions to Innovation in Healthcare Technologies.

    Science.gov (United States)

    Marjanovic, Sonja; Krapels, Joachim; Sousa, Sonia; Castle-Clarke, Sophie; Horvath, Veronika; Chataway, Joanna

    2015-11-30

    The National Institute for Health Research (NIHR) Invention for Innovation (i4i) programme supports the development of innovative medical technologies for patient benefit. The i4i product development stream involves collaborative projects between at least two partners from academia, the NHS and industry. Medical technology innovators apply for funding for one to three years, through a peer review-based process that includes presentation to a selection panel. The funding and business advice provided by i4i support the development of early-stage innovations, generally at proof of concept and prototype stages. Since its inception the product development stream has identified and supported 170 projects, led by 146 principal investigators (PIs). RAND Europe evaluated the programme, with the aim of identifying its outputs and impacts and examining the factors influencing performance. The evaluation findings should help inform the future of the programme. The evaluation used a multi-method approach, including a focused review of background information from i4i, scoping interviews with key informants, a survey of programme participants and case studies of projects representing diverse technologies and health needs.

  12. Modeling Aspects Of Activated Sludge Processes Part I: Process Modeling Of Activated Sludge Facilitation And Sedimentation

    International Nuclear Information System (INIS)

    Ibrahim, H. I.; EI-Ahwany, A.H.; Ibrahim, G.

    2004-01-01

    Process modeling of activated sludge flocculation and sedimentation reviews consider the activated sludge floc characteristics such as: morphology viable and non-viable cell ratio density and water content, bio flocculation and its kinetics were studied considering the characteristics of bio flocculation and explaining theory of Divalent Cation Bridging which describes the major role of cations in bio flocculation. Activated sludge flocculation process modeling was studied considering mass transfer limitations from Clifft and Andrew, 1981, Benefild and Molz 1983 passing Henze 1987, until Tyagi 1996 and G. Ibrahim et aI. 2002. Models of aggregation and breakage of flocs were studied by Spicer and Pratsinis 1996,and Biggs 2002 Size distribution of floes influences mass transfer and biomass separation in the activated sludge process. Therefore, it is of primary importance to establish the role of specific process operation factors, such as sludge loading dynamic sludge age and dissolved oxygen, on this distribution with special emphasis on the formation of primary particles

  13. Determination of the 121Te gamma emission probabilities associated with the production process of radiopharmaceutical NaI[123I

    International Nuclear Information System (INIS)

    Araujo, M.T.F.; Lopes, R.T.; Poledna, R.; Delgado, J.U.; Almeida, M.C.M. de; Silva, R.L.

    2015-01-01

    The 123 I is widely used in radiodiagnostic procedures in nuclear medicine. According to Pharmacopoeia care should be taken during its production process, since radionuclidic impurities may be generated. The 121 Te is an impurity that arises during the 123 I production and determining their gamma emission probabilities (Pγ) is important in order to obtain more information about its decay. Activities were also obtained by absolute standardization using the sum-peak method and these values were compared to the efficiency curve method. (author)

  14. Molecular dynamics simulation of mode-I-crack propagation and dislocation generation processes in α-Fe

    International Nuclear Information System (INIS)

    Wang Jianwei; Lu Guocai; Shang Xinchun

    2011-01-01

    The process of I-mode crack propagations in α-Fe for uniaxial tension experiments are simulated by molecular dynamics (MD) methods. The formation process of dislocation and fracture mechanisms in the crack growing under various temperatures were studied. The results show that the crack propagation is a process of successive emission of dislocation. The dislocation-free zone and the stacking faults were initially formed at crack tip. When the stress K I increased into 0. 566 MPam 1/2 , one layer of atoms near crack tip would be separated into two layers which produced a dislocation. The first dislocation was emitted when stress K I reached 0.669 MPam 1/2 . With the temperature increasing, the critical stress intensity factor decreased gradually and the dislocation emission correspondingly became faster as well. (authors)

  15. Chemical Process for Treatment of Tellurium and Chromium Liquid Waste from I-131 Radioisotope Production

    International Nuclear Information System (INIS)

    Zainus-Salimin; Gunandjar; Dedy-Harsono; Hendro; Sugeng-Purnomo; Mohammad-Faruq; Zulfakhri

    2000-01-01

    The I-131 radioisotope is used in nuclear medicine for diagnosis and therapy. The I-131 radioisotope is produced by wet distillation at Bandung Nuclear Research Center and generated about 4,875 Itr of liquid waste containing 2,532.8 ppm of tellurium and 1,451.8 ppm chromium at pH 1. Considering its negative impact to the environment caused by toxic behaviour of tellurium and chromium, it is necessary to treat chemically that's liquid waste. The research of chemical treatment of tellurium and chromium liquid waste from I-131 radioisotope production has been done. The steps of process are involved of neutralisation with NaOH, coagulation-flocculation process for step I using Ca(OH) 2 coagulant for precipitation of sulphate, sulphite, oxalic, chrome Cr 3+ , and coagulation-flocculation process for step II using BaCI 2 coagulant for precipitation of chrome Cr 6+ and tellurium from the supernatant of coagulation in step I. The best result of experiment was achieved at 0.0161 ppm of chromium concentration on the supernatant from coagulation-flocculation of step I using 3.5 g Ca(OH) 2 for 100 ml of liquid waste, and 0.95 ppm of tellurium concentration on the final supernatant from coagulation-flocculation by of step II using 0.7 g BaCI 2 for supernatant from coagulation of step I. (author)

  16. 31 CFR 363.210 - Is there any period of time during which I will be unable to process certain transactions...

    Science.gov (United States)

    2010-07-01

    ... certain transactions regarding my security? A closed book period will be in effect for four business days... which I will be unable to process certain transactions regarding my security? 363.210 Section 363.210..., DEPARTMENT OF THE TREASURY BUREAU OF THE PUBLIC DEBT REGULATIONS GOVERNING SECURITIES HELD IN TREASURYDIRECT...

  17. A structural model for composite rotor blades and lifting surfaces

    Science.gov (United States)

    Rehfield, Lawrence W.; Atilgan, Ali R.

    1987-01-01

    Composite material systems are currently candidates for aerospace structures, primarily for the design flexibiity they offer i.e., it is possible to tailor the material and manufacturing approach to the application. Two notable examples are the wing of the Grumman/USAF/DARPA X-29 and rotor blades under development by the U.S.A. Aerostructures Directorate (AVSCOM), Langley Research Center. A working definition of elastic or structural tailoring is the use of structural concept, fiber orientation, ply stacking sequence, and a blend of materials to achieve specific performance goals. In the design process, choices of materials and dimensions are made which produce specific response characteristics which permit the selected goals to be achieved. Common choices for tailoring goals are preventing instabilities or vibration resonances or enhancing damage tolerance. An essential, enabling factor in the design of tailored composite structures is structural modeling that accurately, but simply, characterizes response. The objective of this paper is to improve the single-cell beam model for composite rotor blades or lifting surfaces and to demonstrate its usefullness in applications.

  18. iBiology: communicating the process of science.

    Science.gov (United States)

    Goodwin, Sarah S

    2014-08-01

    The Internet hosts an abundance of science video resources aimed at communicating scientific knowledge, including webinars, massive open online courses, and TED talks. Although these videos are efficient at disseminating information for diverse types of users, they often do not demonstrate the process of doing science, the excitement of scientific discovery, or how new scientific knowledge is developed. iBiology (www.ibiology.org), a project that creates open-access science videos about biology research and science-related topics, seeks to fill this need by producing videos by science leaders that make their ideas, stories, and experiences available to anyone with an Internet connection. © 2014 Goodwin. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

  19. Equipment and obtention process of 131I by dry distillation starting from TeO2

    International Nuclear Information System (INIS)

    Alanis M, J.

    2000-08-01

    The present invention refers to an equipment and process for the obtaining of 131 I by dry distillation starting from TeO 2 that has three interconnected systems, the manipulation system, the electric system and the distillation system, the combination of these systems, allows to improve the yield and the separation of the 131 I during the distillation process, since inside the electric system it is an oven that has a special design based on a temperature gradient. The more relevant aspects of the equipment its are the design of each one of its components that give as result the effectiveness of the production of 131 I in routinary form (industrial) whose final product can end up reaching a radiochemical purity up to 99% and a radionuclide purity of approximately 100%. The object of this invention is to provide a distillation equipment different to those that at the moment exist, thanks to its novel internal construction whose main characteristics already gather advantages on those existent. The reaction of obtaining of the TeO 2 , the development of the technique and studies of TeO 2 sintering and the irradiation experiments, its contributed to characterize with more precision the 'new process of obtaining of 131 I by dry via starting from the Te' developed in the ININ, and in this way it was achieved a more pure product, more economic, with less risks, from a point of view of Radiological Safety and mainly that it avoids the import to the country and it makes to self-sufficient Mexico in the production of 131 I. (Author)

  20. EMPRESS: A European Project to Enhance Process Control Through Improved Temperature Measurement

    Science.gov (United States)

    Pearce, J. V.; Edler, F.; Elliott, C. J.; Rosso, L.; Sutton, G.; Andreu, A.; Machin, G.

    2017-08-01

    A new European project called EMPRESS, funded by the EURAMET program `European Metrology Program for Innovation and Research,' is described. The 3 year project, which started in the summer of 2015, is intended to substantially augment the efficiency of high-value manufacturing processes by improving temperature measurement techniques at the point of use. The project consortium has 18 partners and 5 external collaborators, from the metrology sector, high-value manufacturing, sensor manufacturing, and academia. Accurate control of temperature is key to ensuring process efficiency and product consistency and is often not achieved to the level required for modern processes. Enhanced efficiency of processes may take several forms including reduced product rejection/waste; improved energy efficiency; increased intervals between sensor recalibration/maintenance; and increased sensor reliability, i.e., reduced amount of operator intervention. Traceability of temperature measurements to the International Temperature Scale of 1990 (ITS-90) is a critical factor in establishing low measurement uncertainty and reproducible, consistent process control. Introducing such traceability in situ (i.e., within the industrial process) is a theme running through this project.

  1. ASKGene, a system for automate DNA processing - DOI: 10.3395/reciis.v1i2.Sup.100en

    Directory of Open Access Journals (Sweden)

    Eden Cardim

    2007-12-01

    Full Text Available Computational resources have become essential for genome project development. Distributed systems managing complex structures integrating graphical user interfaces, expensive data processing, data mining and large databases, have been proposed. Most consolidated sequencing laboratories have developed their own bioinformatics solutions. However, a portable and scalable system integrating all these aspects is not yet available to the scientific community. In this report, we present the prototype of such a system in open development at http://sourceforge.net/projects/askgene. It allows for the (i accessibility of data and processes all along the data flow, (ii data representation and ontology, (iii workflow tuning, (iv system architecture and documentation, (v corporate development, (vi manual annotation, (vii bogus data processing, (viii process parallelization and distribution, (ix portability and scalability.

  2. VOMS Server replication process in I2G and EELA Project

    International Nuclear Information System (INIS)

    Rodrigues Silva, B.; Gomes, J.; Montecelo, M.

    2007-01-01

    This paper presents the VOMS server replication process in the I2G and EELA projects, including a detailed description about how to implement the MySQL database replication. After that it enumerates most of the VOMS server replication related problems and their respective solutions implemented at LIP in Portugal. In the end a proposal is made about how to extend this approach to other core service named LCG File Catalog. (Author)

  3. Safety aspects of the modernization of I and C and process information in nuclear power plants with special regard to alarm annunciation

    Energy Technology Data Exchange (ETDEWEB)

    Seidel, F [Bundesamt fuer Strahlenschutz, Salzgitter (Germany)

    1997-09-01

    In particular for older German nuclear power plants there are projects to modernize I and C and process information systems. This modernization mainly aims at improvements in plant operation. For instance, using modern computing technology, the plant operation can be optimized, according to further details. Furthermore, the problem of spare-part keeping for out-dated components can be solved. For modernizing the I and C or the process computer system, safety-relevant aspects have to be taken into account. For instance, the compatibility of the system modification with the existing alarm annunciation concept shall be considered, and for each modernization step, the interfaces between the equipment of different safety significance shall be assessed and observed. The functions and the associated equipment have to be qualified in accordance to their safety significance. At present, the regulatory framework for computer-based instrumentation and control as well as for information systems is being elaborated in Germany and worldwide. Recently, the guidelines of the German Reactor Safety Commission have been extended with regard to the introduction and safety application of modern computer-based I and C in nuclear power plants. Furthermore, some of the essential requirements for design and qualification of modern I and C can be derived from the existing rules and standards. Particularly, concerning the alarm annunciation system, this report summarizes safety-relevant aspects of the modernization of the instrumentation and control system as well as the process information system in nuclear power plants. (author). 4 refs.

  4. Safety aspects of the modernization of I and C and process information in nuclear power plants with special regard to alarm annunciation

    International Nuclear Information System (INIS)

    Seidel, F.

    1997-01-01

    In particular for older German nuclear power plants there are projects to modernize I and C and process information systems. This modernization mainly aims at improvements in plant operation. For instance, using modern computing technology, the plant operation can be optimized, according to further details. Furthermore, the problem of spare-part keeping for out-dated components can be solved. For modernizing the I and C or the process computer system, safety-relevant aspects have to be taken into account. For instance, the compatibility of the system modification with the existing alarm annunciation concept shall be considered, and for each modernization step, the interfaces between the equipment of different safety significance shall be assessed and observed. The functions and the associated equipment have to be qualified in accordance to their safety significance. At present, the regulatory framework for computer-based instrumentation and control as well as for information systems is being elaborated in Germany and worldwide. Recently, the guidelines of the German Reactor Safety Commission have been extended with regard to the introduction and safety application of modern computer-based I and C in nuclear power plants. Furthermore, some of the essential requirements for design and qualification of modern I and C can be derived from the existing rules and standards. Particularly, concerning the alarm annunciation system, this report summarizes safety-relevant aspects of the modernization of the instrumentation and control system as well as the process information system in nuclear power plants. (author). 4 refs

  5. New Generator Technology

    Energy Technology Data Exchange (ETDEWEB)

    Nielsen, Roy S. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-02-17

    New generator technology project is driven by the need to be able to remotely deploy generator technology where it is needed, when it is needed. Both the military and aid programs that provide assistance after disasters could use the ability to deploy energy generation that fits the needs of the situation. Currently, pre-specified generators are deployed, sometime more than half way around the world to provide electricity. Through our Phase-I to Phase III DARPA grant, we will provide a mechanism where a 3d print station and raw materials could be shipped to a deployment site and remotely deployed personnel. These remote personnel can collaborate with engineers at a home location where 3d print plans can be optimized for the remote purpose. The plans can then be sent electronically to the remote location for printing, much like NASA sent the plans for a socket wrench to the International Space Station for printing in . If multiple generators need to be deployed at different remote locations, within miles of each other the printer rig can be moved to print the generators where they are needed. 3d printing is growing in the field of manufacturing. 3d printing has matured to the point where many types of materials are now available for many types of manufacturing. Both magnetic and electrically conductive material materials have recently been developed which can now lead to 3d printing of engines and generators. Our project will provide a successful printer rig that can be remotely deployed, to print a generator design in the field as well as provide a process for deploying the printed generator as well. This Systems Engineering Management Plan(SEMP) will provide the planning required for a Phase I DARPA grant that may also include goals for Phase II and Phase II grants. The SEMP provides a proposed project schedule, references, system engineering processes, specialty engineering system deployment and product support sections. Each section will state how our company

  6. Switching process between bistable positons of multiquantum flux tubes in a thin-film type I superconductor

    International Nuclear Information System (INIS)

    Parisi, J.; Huebener, R.P.; Muhlemeier, B.

    1983-01-01

    A superconducting memory device based on a bistable vortex position represents an interesting storage medium for future Josephson computers. In order to study the operational mode of such a single-flux quantum memory cell, we use as a model system multiquantum flux tubes in a thin-film type I superconductor (Pb). By employing high-resolution stroboscopic magnetooptical flux detection, we are able to globally visualize both spatial and temporal behavior of rapidly switching individual flux tubes. All experimental results agree reasonably well with theoretical model considerations of the energy balance during the elementary switching process

  7. Prediction of the combustion process and emission formation of a bi-fuel s.i. engine

    International Nuclear Information System (INIS)

    D'Errico, Gianluca

    2008-01-01

    A thermodynamic model is developed and validated for the prediction of the combustion process and pollutant formation in s.i. engines, fuelled by gasoline and compressed natural gas. Attention is focused on the main physical and chemical phenomena to allow a reliable evaluation of the burning rate and of the specie concentrations, including intermediates such as CO, O, H, and OH. A new correlation for laminar flame speed of methane-air mixtures is derived by interpolating more than 1000 different conditions at high pressure and temperature, computed by a detailed chemical approach. Successively an extended dissertation about the fundamental mechanisms which govern the pollutant formation in the turbulent premixed combustion which characterizes the s.i. engines is given. The conclusion of such analysis is the definition of a new reduced chemical scheme, based on the application of partial-equilibrium and steady-state assumptions for the radicals and the solution of a transport equation for each specie which is kinetically controlled. Finally the proposed schemes and formulations were embedded into the developed quasi-D model and into a CFD code, to simulate a s.i. engine fuelled by gasoline and CNG, allowing a deeper understanding of the reliability of the simplifications made in the quasi-dimensional model and a comprehensive investigation of several physical and chemical properties, whose experimental measurement is not usually available. Computed results were compared with the available experimental data of in-cylinder pressure histories and engine emissions for two different engine configurations

  8. Close-Out Report for FY2002 - FY2005, DARPA Agreement

    Science.gov (United States)

    2010-06-29

    management and programming; NC Machine tool engineering and supervising; diagnostic equipment and maintenance; MIG, TIG and ARC welding ; Non-destructive...region’s companies to develop new products and processes as well as secure and maintain contracts with both NASA and the DoD. RCBI became recognized as a...from those obtained from hand tools and reducing the time involved in the process , CMMs ensure the quality of a product for manufacturers and reduce

  9. Active learning electromagnetism with iPhone, iPod Touch and iPad: a new teaching resource

    OpenAIRE

    Arribas Garde, Enrique; Nájera López, Alberto; Beléndez Vázquez, Augusto; Francés Monllor, Jorge; Mora Ley, César Eduardo; Franco, María Teresa; Moratalla Mondéjar, Gonzalo

    2012-01-01

    The proliferation of so-called smart phones (among which we include the iPhone) and tablets (iPad and iPod Touch) is leading to these devices to be focused by teachers and researchers. Their power of calculation and their graphic capabilities make them to be extremely attractive for trying to increase the process of teaching and learning in a highly significant manner. Smart phones and other similar devices provide new ways of learning that we believe it is necessary to explore. They are also...

  10. Micromechanical Disk Array for Enhanced Frequency Stability Against Bias Voltage Fluctuations

    Science.gov (United States)

    2014-11-20

    Notably oscillators referenced to very high Q capacitive-gap transduced MEMS resonators have already made inroads into the low-end timing market , and...already made inroads into the low-end timing market , and research devices have been reported to satisfy GSM phase noise requirements while only...BSAC a perfect environment for graduate students to learn and grow professionally. Lastly, I would like to thank DARPA, BSAC, and Samsung for the

  11. Creating Stop-Motion Videos with iPads to Support Students' Understanding of Cell Processes: "Because You Have to Know What You're Talking about to Be Able to Do It"

    Science.gov (United States)

    Deaton, Cynthia C. M.; Deaton, Benjamin E.; Ivankovic, Diana; Norris, Frank A.

    2013-01-01

    The purpose of this qualitative case study is two-fold: (a) describe the implementation of a stop-motion animation video activity to support students' understanding of cell processes, and (b) present research findings about students' beliefs and use of iPads to support their creation of stop-motion videos in an introductory biology course. Data…

  12. A empiric expression to interpret the approximation of λ cI phages to E. coli C600 bacteria

    International Nuclear Information System (INIS)

    Garces, F.; Vidania, R. de

    1984-01-01

    In general the process of adsorption of phages to bacteria is considered in the bibliography as an statistical process. In this work we use an empiric expression which allows to interpret the approximation of λcI pages to E. coli C 6 00 bacteria. This expression introduces some changes respect to a pure statistical description of the approximation process. (Author) 26 refs

  13. Automation of processing and photometric data analysis for transiting exoplanets observed with ESO NIR instrument HAWK-I

    Science.gov (United States)

    Blažek, M.; Kabáth, P.; Klocová, T.; Skarka, M.

    2018-04-01

    Nowadays, when amount of data still increases, it is necessary to automatise their processing. State-of-the-art instruments are capable to produce even tens of thousands of images during a single night. One of them is HAWK-I that is a part of Very Large Telescope of European Southern Observatory. This instrument works in near-infrared band. In my Master thesis, I dealt with developing a pipeline to process data obtained by the instrument. It is written in Python programming language using commands of IRAF astronomical software and it is developed directly for "Fast Photometry Mode" of HAWK-I. In this mode, a large number of data has been obtained during secondary eclipses of exoplanets by their host star. The pipeline was tested by a data set from sorting of the images to making a light curve. The data of WASP-18 system contained almost 40 000 images observed by using a filter centered at 2.09 μm wavelength and there is a plan to process other data sets. A goal of processing of WASP-18 and the other data sets is consecutive analysis of exoplanetary atmospheres of the observed systems.

  14. Conceptual information processing: A robust approach to KBS-DBMS integration

    Science.gov (United States)

    Lazzara, Allen V.; Tepfenhart, William; White, Richard C.; Liuzzi, Raymond

    1987-01-01

    Integrating the respective functionality and architectural features of knowledge base and data base management systems is a topic of considerable interest. Several aspects of this topic and associated issues are addressed. The significance of integration and the problems associated with accomplishing that integration are discussed. The shortcomings of current approaches to integration and the need to fuse the capabilities of both knowledge base and data base management systems motivates the investigation of information processing paradigms. One such paradigm is concept based processing, i.e., processing based on concepts and conceptual relations. An approach to robust knowledge and data base system integration is discussed by addressing progress made in the development of an experimental model for conceptual information processing.

  15. Reproducible Data Processing Research for the CABRI R.I.A. experiments Acoustic Emission signal analysis

    Energy Technology Data Exchange (ETDEWEB)

    Pantera, Laurent [CEA, DEN, CAD/DER/SRES/LPRE, Cadarache, F-13108 Saint-Paul-lez-Durance (France); Issiaka Traore, Oumar [Laboratory of Machanics and Acoustics (LMA) CNRS, 13402 Marseille (France)

    2015-07-01

    The CABRI facility is an experimental nuclear reactor of the French Atomic Energy Commission (CEA) designed to study the behaviour of fuel rods at high burnup under Reactivity Initiated Accident (R.I.A.) conditions such as the scenario of a control rod ejection. During the experimental phase, the behaviour of the fuel element generates acoustic waves which can be detected by two microphones placed upstream and downstream from the test device. Studies carried out on the last fourteen tests showed the interest in carrying out temporal and spectral analyses on these signals by showing the existence of signatures which can be correlated with physical phenomena. We want presently to return to this rich data in order to have a new point of view by applying modern signal processing methods. Such an antecedent works resumption leads to some difficulties. Although all the raw data are accessible in the form of text files, analyses and graphics representations were not clear in reproducing from the former studies since the people who were in charge of the original work have left the laboratory and it is not easy when time passes, even with our own work, to be able to remember the steps of data manipulations and the exact setup. Thus we decided to consolidate the availability of the data and its manipulation in order to provide a robust data processing workflow to the experimentalists before doing any further investigations. To tackle this issue of strong links between data, treatments and the generation of documents, we adopted a Reproducible Research paradigm. We shall first present the tools chosen in our laboratory to implement this workflow and, then we shall describe the global perception carried out to continue the study of the Acoustic Emission signals recorded by the two microphones during the last fourteen CABRI R.I.A. tests. (authors)

  16. Repairing process models to reflect reality

    NARCIS (Netherlands)

    Fahland, D.; Aalst, van der W.M.P.; Barros, A.; Gal, A.; Kindler, E.

    2012-01-01

    Process mining techniques relate observed behavior (i.e., event logs) to modeled behavior (e.g., a BPMN model or a Petri net). Processes models can be discovered from event logs and conformance checking techniques can be used to detect and diagnose differences between observed and modeled behavior.

  17. A Leu to Ile but not Leu to Val change at HIV-1 reverse transcriptase codon 74 in the background of K65R mutation leads to an increased processivity of K65R+L74I enzyme and a replication competent virus

    Directory of Open Access Journals (Sweden)

    Crumpacker Clyde S

    2011-01-01

    Full Text Available Abstract Background The major hurdle in the treatment of Human Immunodeficiency virus type 1 (HIV-1 includes the development of drug resistance-associated mutations in the target regions of the virus. Since reverse transcriptase (RT is essential for HIV-1 replication, several nucleoside analogues have been developed to target RT of the virus. Clinical studies have shown that mutations at RT codon 65 and 74 which are located in β3-β4 linkage group of finger sub-domain of RT are selected during treatment with several RT inhibitors, including didanosine, deoxycytidine, abacavir and tenofovir. Interestingly, the co-selection of K65R and L74V is rare in clinical settings. We have previously shown that K65R and L74V are incompatible and a R→K reversion occurs at codon 65 during replication of the virus. Analysis of the HIV resistance database has revealed that similar to K65R+L74V, the double mutant K65R+L74I is also rare. We sought to compare the impact of L→V versus L→I change at codon 74 in the background of K65R mutation, on the replication of doubly mutant viruses. Methods Proviral clones containing K65R, L74V, L74I, K65R+L74V and K65R+L74I RT mutations were created in pNL4-3 backbone and viruses were produced in 293T cells. Replication efficiencies of all the viruses were compared in peripheral blood mononuclear (PBM cells in the absence of selection pressure. Replication capacity (RC of mutant viruses in relation to wild type was calculated on the basis of antigen p24 production and RT activity, and paired analysis by student t-test was performed among RCs of doubly mutant viruses. Reversion at RT codons 65 and 74 was monitored during replication in PBM cells. In vitro processivity of mutant RTs was measured to analyze the impact of amino acid changes at RT codon 74. Results Replication kinetics plot showed that all of the mutant viruses were attenuated as compared to wild type (WT virus. Although attenuated in comparison to WT virus

  18. Decoherence due to elastic rayleigh scattering

    CSIR Research Space (South Africa)

    Uys, H

    2010-11-01

    Full Text Available . acknowledges support from Georgia Tech and IARPA. D.M. is supported by NSF. This work was supported by the DARPA OLE program and by IARPA. This manuscript is the contribution of NIST and is not subject to U.S. copyright. *huys@csir.co.za †john...

  19. Luminescence properties of pure and Eu-doped SrI{sub 2} crystals purified by a “Liquinert” process and grown by vertical Bridgman method

    Energy Technology Data Exchange (ETDEWEB)

    Kawai, Taketoshi, E-mail: buri@p.s.osakafu-u.ac.jp [Osaka Prefecture University, Gakuen-cho 1-1, Naka-ku, Sakai, Osaka 599-8531 (Japan); Sakuragi, Shiro; Hashimoto, Satoshi [Union Materials Inc. 1640 Oshido, Tone-machi, Ibaraki 300-1602 (Japan)

    2016-08-15

    We have prepared high quality crystals of pure SrI{sub 2} and Eu-doped SrI{sub 2} by our original “Liquinert” process and investigated their luminescence properties. Under the excitation with the 193 nm light of an ArF excimer laser, which corresponds to the wavelength above the bandgap of SrI{sub 2} bulk crystals, the pure and Eu doped SrI{sub 2} crystals exhibit no luminescence band related to defects or impurities around 560 nm. This fact indicates that the crystals prepared by the “Liquinert” process contain lower defects and/or impurities. When the Eu-doped SrI{sub 2} crystals are excited with the 325 nm light of a He–Cd laser, only the luminescence band due to the 5d→4f transition in the Eu{sup 2+} ions is observed around 425 nm. The 425 nm band observed at a forward configuration exhibits the shift to the longer wavelength side and the decrease of the luminescence intensity with increasing Eu concentration. The Eu concentration dependences of the peak wavelength and luminescence intensity are simulated on the basis of a simple self-absorption model. - Highlights: • Our original “Liquinert” process allows us to prepare high quality crystals of SrI{sub 2}. • No luminescence band related with impurities and/or defects is observed. • The 425 nm luminescence bands due to Eu{sup 2+} ions are affected by a self-absorption. • A simple self-absorption model reproduces the changes of the 425 nm bands.

  20. A low-fat, whole-food vegan diet, as well as other strategies that down-regulate IGF-I activity, may slow the human aging process.

    Science.gov (United States)

    McCarty, Mark F

    2003-06-01

    A considerable amount of evidence is consistent with the proposition that systemic IGF-I activity acts as pacesetter in the aging process. A reduction in IGF-I activity is the common characteristic of rodents whose maximal lifespan has been increased by a wide range of genetic or dietary measures, including caloric restriction. The lifespans of breeds of dogs and strains of rats tend to be inversely proportional to their mature weight and IGF-I levels. The link between IGF-I and aging appears to be evolutionarily conserved; in worms and flies, lifespan is increased by reduction-of-function mutations in signaling intermediates homologous to those which mediate insulin/IGF-I activity in mammals. The fact that an increase in IGF-I activity plays a key role in the induction of sexual maturity, is consistent with a broader role for-IGF-I in aging regulation. If down-regulation of IGF-I activity could indeed slow aging in humans, a range of practical measures for achieving this may be at hand. These include a low-fat, whole-food, vegan diet, exercise training, soluble fiber, insulin sensitizers, appetite suppressants, and agents such as flax lignans, oral estrogen, or tamoxifen that decrease hepatic synthesis of IGF-I. Many of these measures would also be expected to decrease risk for common age-related diseases. Regimens combining several of these approaches might have a sufficient impact on IGF-I activity to achieve a useful retardation of the aging process. However, in light of the fact that IGF-I promotes endothelial production of nitric oxide and may be of especial importance to cerebrovascular health, additional measures for stroke prevention-most notably salt restriction-may be advisable when attempting to down-regulate IGF-I activity as a pro-longevity strategy.

  1. Digital Didactical Designs: Teachers' Integration of iPads for Learning-Centered Processes

    Science.gov (United States)

    Jahnke, Isa; Kumar, Swapna

    2014-01-01

    This research presents five examples of how teachers integrated iPads into their classrooms, as part of a larger study of 15 Danish classrooms. Classroom observations and interviews with teachers revealed the use of multiple apps and a focus on creativity, production, and collaboration in the learning process. We discuss the results in the context…

  2. Development of a General-Purpose Analysis System Based on a Programmable Fluid Processor Final Report CRADA No. TC-2027-01

    Energy Technology Data Exchange (ETDEWEB)

    McConaghy, C. F. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Gascoyne, P. R. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2017-09-28

    The purpose ofthis project was to develop a general-purpose analysis system based on a programmable fluid processor (PFP). The PFP is an array of electrodes surrounded by fluid reservoirs and injectors. Injected droplets of various reagents are manjpulated and combined on the array by Dielectrophoretic (DEP) forces. The goal was to create a small handheld device that could accomplish the tasks currently undertaken by much larger, time consuming, manual manipulation in the lab. The entire effo1t was funded by DARPA under the Bio-Flips program. MD Anderson Cancer Center was the PI for the DARPA effort. The Bio-Flips program was a 3- year program that ran from September 2000 to September 2003. The CRADA was somewhat behind the Bi-Flips program running from June 2001 to June 2004 with a no cost extension to September 2004.

  3. Determination of the {sup 121}Te gamma emission probabilities associated with the production process of radiopharmaceutical NaI[{sup 123}I

    Energy Technology Data Exchange (ETDEWEB)

    Araujo, M.T.F.; Lopes, R.T., E-mail: maraujo@con.ufrj.br, E-mail: miriamtaina@hotmail.com [Coordenacao dos Cursos de Pos-Graduacao em Engenharia (LIN/PEN/COPPE/UFRJ), RJ (Brazil). Programa de Engenharia Nuclear. Lab. de Instrumentacao Nuclear; Poledna, R.; Delgado, J.U.; Almeida, M.C.M. de; Silva, R.L. [Instituto de Radioprotecao e Dosimetria (IRD/CNEN-RJ/LNMRI), Rio de Janeiro, RJ (Brazil). Lab. Nacional de Metrologia das Radiacoes Ionizantes

    2015-07-01

    The {sup 123}I is widely used in radiodiagnostic procedures in nuclear medicine. According to Pharmacopoeia care should be taken during its production process, since radionuclidic impurities may be generated. The {sup 121}Te is an impurity that arises during the {sup 123}I production and determining their gamma emission probabilities (Pγ) is important in order to obtain more information about its decay. Activities were also obtained by absolute standardization using the sum-peak method and these values were compared to the efficiency curve method. (author)

  4. Improvement of the obtention process of 131 I of ININ through studies of equipment design and process parameters fitting in the simulator

    International Nuclear Information System (INIS)

    Zepeda M, M.C.

    2006-01-01

    The main objective of the work was to achieve a high yield of the reaction that happens among the vapors of 131 I and the NaOH to obtain sodium iodide (Na 131 I) in solution optimizing the contact time of the molecules in gaseous state of 131 I with the NaOH molecules through the bubbling velocity of the 131 I in the solution of NaOH 0.1 N, as well as the operation temperature during the distillation process by dry via starting from tellurium dioxide (TeO 2 ) with the purpose of that the 131 I that is obtained in the form of Na 131 I solution presents the necessary quality that allows to distribute it in the market. The particular objectives were: a) To improve the distillation equipment used for the obtaining of 131 I starting from irradiated tellurium dioxide redrawing the dilution system with the purpose of recovering the 131 I in a minimum volume of sodium hydroxide (NaOH). b) To achieve a bigger time of contact among the molecules of 131 I in gaseous state with the molecules of NaOH in solution through the bubbling velocity and of the redrawing of the dilution system. c) To implement the production of 131 I by dry distillation via starting from tellurium dioxide, obtaining it with a high radionuclide and radiochemical purity. d) To obtain 131 I with the necessary specifications that it marks the pharmacopoeia and it can be used with medical ends. (Author)

  5. DEFACTO: A Design Environment for Adaptive Computing Technology

    National Research Council Canada - National Science Library

    Hall, Mary

    2003-01-01

    This report describes the activities of the DEFACTO project, a Design Environment for Adaptive Computing Technology funded under the DARPA Adaptive Computing Systems and Just-In-Time-Hardware programs...

  6. Modeling the effect of urban infrastructure on hydrologic processes within i-Tree Hydro, a statistically and spatially distributed model

    Science.gov (United States)

    Taggart, T. P.; Endreny, T. A.; Nowak, D.

    2014-12-01

    Gray and green infrastructure in urban environments alters many natural hydrologic processes, creating an urban water balance unique to the developed environment. A common way to assess the consequences of impervious cover and grey infrastructure is by measuring runoff hydrographs. This focus on the watershed outlet masks the spatial variation of hydrologic process alterations across the urban environment in response to localized landscape characteristics. We attempt to represent this spatial variation in the urban environment using the statistically and spatially distributed i-Tree Hydro model, a scoping level urban forest effects water balance model. i-Tree Hydro has undergone expansion and modification to include the effect of green infrastructure processes, road network attributes, and urban pipe system leakages. These additions to the model are intended to increase the understanding of the altered urban hydrologic cycle by examining the effects of the location of these structures on the water balance. Specifically, the effect of these additional structures and functions on the spatially varying properties of interception, soil moisture and runoff generation. Differences in predicted properties and optimized parameter sets between the two models are examined and related to the recent landscape modifications. Datasets used in this study consist of watersheds and sewersheds within the Syracuse, NY metropolitan area, an urban area that has integrated green and gray infrastructure practices to alleviate stormwater problems.

  7. Automated Aerial Refueling Presentation to 2007 ARSAG Conference (Preprint)

    Science.gov (United States)

    2007-04-01

    this technology allows manned or unmanned platforms to fly formation in IFR conditions. 3 3Approved for public release; distribution is unlimited...conducted in conjunction with the DARPA TTNT China Lake test It was determine that TTNT needed slight modifications which have been incorporated. Station

  8. Learning iPhone Programming From Xcode to App Store

    CERN Document Server

    Allan, Alasdair

    2010-01-01

    Get the hands-on experience you need to program for the iPhone and iPod Touch. With this easy-to-follow guide, you'll build several sample applications by learning how to use Xcode tools, the Objective-C programming language, and the core frameworks. Before you know it, you'll not only have the skills to develop your own apps, you'll know how to sail through the process of submitting apps to the iTunes App Store. Whether you're a developer new to Mac programming or an experienced Mac developer ready to tackle the iPhone and iPod Touch, Learning iPhone Programming will give you a head start o

  9. Photovoltaic Performance of Vapor-Assisted Solution-Processed Layer Polymorph of Cs3Sb2I9.

    Science.gov (United States)

    Singh, Anupriya; Boopathi, Karunakara Moorthy; Mohapatra, Anisha; Chen, Yang Fang; Li, Gang; Chu, Chih Wei

    2018-01-24

    The presence of toxic lead (Pb) remains a major obstruction to the commercial application of perovskite solar cells. Although antimony (Sb)-based perovskite-like structures A 3 M 2 X 9 can display potentially useful photovoltaic behavior, solution-processed Sb-based perovskite-like structures usually favor the dimer phase, which has poor photovoltaic properties. In this study, we prepared a layered polymorph of Cs 3 Sb 2 I 9 through solution-processing and studied its photovoltaic properties. The exciton binding energy and exciton lifetime of the layer-form Cs 3 Sb 2 I 9 were approximately 100 meV and 6 ns, respectively. The photovoltaic properties of the layered polymorph were superior to those of the dimer polymorph. A solar cell incorporating the layer-form Cs 3 Sb 2 I 9 exhibited an open-circuit voltage of 0.72 V and a power conversion efficiency of 1.5%-the highest reported for an all-inorganic Sb-based perovskite.

  10. The I.A.G. / A.I.G. SEDIBUD Book Project: Source-to-Sink Fluxes in Undisturbed Cold Environments

    Science.gov (United States)

    Beylich, Achim A.; Dixon, John C.; Zwolinski, Zbigniew

    2015-04-01

    The currently prepared SEDIBUD Book on "Source-to-Sink Fluxes in Undisturbed Cold Environments" (edited by Achim A. Beylich, John C. Dixon and Zbigniew Zwolinski and published by Cambridge University Press) is summarizing and synthesizing the achievements of the International Association of Geomorphologists` (I.A.G./A.I.G.) Working Group SEDIBUD (Sediment Budgets in Cold Environments), which has been active since 2005 (http://www.geomorph.org/wg/wgsb.html). Amplified climate change and ecological sensitivity of largely undisturbed polar and high-altitude cold climate environments have been highlighted as key global environmental issues. The effects of projected climate change will change surface environments in cold regions and will alter the fluxes of sediments, nutrients and solutes, but the absence of quantitative data and coordinated geomorphic process monitoring and analysis to understand the sensitivity of the Earth surface environment in these largely undisturbed environments is acute. Our book addresses this existing key knowledge gap. The applied approach of integrating comparable and longer-term field datasets on contemporary solute and sedimentary fluxes from a number of different defined cold climate catchment geosystems for better understanding (i) the environmental drivers and rates of contemporary denudational surface processes and (ii) possible effects of projected climate change in cold regions is unique in the field of geomorphology. Largely undisturbed cold climate environments can provide baseline data for modeling the effects of environmental change. The book synthesizes work carried out by numerous SEDIBUD Members over the last decade in numerous cold climate catchment geosystems worldwide. For reaching a global cover of different cold climate environments the book is - after providing an introduction part and a basic part on climate change in cold environments and general implications for solute and sedimentary fluxes - dealing in different

  11. Multiband Radio Frequency Interconnect (MRFI) Technology For Next Generation Mobile/Airborne Computing Systems

    Science.gov (United States)

    2017-02-01

    between CPUs and memories , and then demodulated by the same frequency carriers to restore the data back to a parallel bus. This implies that one can...performance. With limited I/O pin count, higher bandwidth implies higher data rate per pin. As the data rate of double data rate (DDR) memory ...either expressed or implied , of Air Force Research Laboratory (AFRL) and the Defense Advanced Research Agency (DARPA) or the U.S. Government. Report

  12. A situated approach to student’s reflection processes

    DEFF Research Database (Denmark)

    Wegener, Charlotte

    2011-01-01

    This paper connects with the conference themes “Vocational Education, Labour Markets and Learning”. In Denmark the social and health care education is part of the Vocational Education System, which combines school attendance and trainee service in the social and health care sector. Throughout...... the education, the students are required to reflect upon their own learning processes, and how to combine theoretical knowledge and practical skills. The students are required to document their reflection processes in two formats: 1) log writing and 2) self-evaluation according to a list of endpoint work skills....... The log and the list of work skills play a central role as entry point in the teachers’ and supervisors’ formal learning dialogues with the students. Based upon an ethnographic field study at a social and health care college, and at the workplaces where students work as trainees, I have observed that some...

  13. A methodology for fault diagnosis in large chemical processes and an application to a multistage flash desalination process: Part II

    International Nuclear Information System (INIS)

    Tarifa, Enrique E.; Scenna, Nicolas J.

    1998-01-01

    In Part I, an efficient method for identifying faults in large processes was presented. The whole plant is divided into sectors by using structural, functional, or causal decomposition. A signed directed graph (SDG) is the model used for each sector. The SDG represents interactions among process variables. This qualitative model is used to carry out qualitative simulation for all possible faults. The output of this step is information about the process behaviour. This information is used to build rules. When a symptom is detected in one sector, its rules are evaluated using on-line data and fuzzy logic to yield the diagnosis. In this paper the proposed methodology is applied to a multiple stage flash (MSF) desalination process. This process is composed of sequential flash chambers. It was designed for a pilot plant that produces drinkable water for a community in Argentina; that is, it is a real case. Due to the large number of variables, recycles, phase changes, etc., this process is a good challenge for the proposed diagnosis method

  14. A method for synthesizing response functions of NaI detectors to gamma rays

    International Nuclear Information System (INIS)

    Sie, S.H.

    1978-08-01

    A simple method of parametrizing the response function of NaI detectors to gamma rays is described, based on decomposition of the pulse-height spectrum into components associated with the actual detection processes. Smooth dependence of the derived parameters on the gamma-ray energy made it possible to generate a lineshape for any gamma-ray energy by suitable interpolation techniques. The method is applied in analysis of spectra measured with a 7.6 x 7.6 cm NaI detector in continuum gamma-ray study following (HI,xn) reaction

  15. Control of PbI2 nucleation and crystallization: towards efficient perovskite solar cells based on vapor-assisted solution process

    Science.gov (United States)

    Yang, Chongqiu; Peng, Yanke; Simon, Terrence; Cui, Tianhong

    2018-04-01

    Perovskite solar cells (PSC) have outstanding potential to be low-cost, high-efficiency photovoltaic devices. The PSC can be fabricated by numerous techniques; however, the power conversion efficiency (PCE) for the two-step-processed PSC falls behind that of the one-step method. In this work, we investigate the effects of relative humidity (RH) and dry air flow on the lead iodide (PbI2) solution deposition process. We conclude that the quality of the PbI2 film is critical to the development of the perovskite film and the performance of the PSC device. Low RH and dry air flow used during the PbI2 spin coating procedure can increase supersaturation concentration to form denser PbI2 nuclei and a more suitable PbI2 film. Moreover, airflow-assisted PbI2 drying and thermal annealing steps can smooth transformation from the nucleation stage to the crystallization stage.

  16. In silico design of fragment-based drug targeting host processing α-glucosidase i for dengue fever

    Science.gov (United States)

    Toepak, E. P.; Tambunan, U. S. F.

    2017-02-01

    Dengue is a major health problem in the tropical and sub-tropical regions. The development of antiviral that targeting dengue’s host enzyme can be more effective and efficient treatment than the viral enzyme. Host enzyme processing α-glucosidase I has an important role in the maturation process of dengue virus envelope glycoprotein. The inhibition of processing α-glucosidase I can become a promising target for dengue fever treatment. The antiviral approach using in silico fragment-based drug design can generate drug candidates with high binding affinity. In this research, 198.621 compounds were obtained from ZINC15 Biogenic Database. These compounds were screened to find the favorable fragments according to Rules of Three and pharmacological properties. The screening fragments were docked into the active site of processing α-glucosidase I. The potential fragment candidates from the molecular docking simulation were linked with castanospermine (CAST) to generate ligands with a better binding affinity. The Analysis of ligand - enzyme interaction showed ligands with code LRS 22, 28, and 47 have the better binding free energy than the standard ligand. Ligand LRS 28 (N-2-4-methyl-5-((1S,3S,6S,7R,8R,8aR)-1,6,7,8-tetrahydroxyoctahydroindolizin-3-yl) pentyl) indolin-1-yl) propionamide) itself among the other ligands has the lowest binding free energy. Pharmacological properties prediction also showed the ligands LRS 22, 28, and 47 can be promising as the dengue fever drug candidates.

  17. Low-cost uncooled VOx infrared camera development

    Science.gov (United States)

    Li, Chuan; Han, C. J.; Skidmore, George D.; Cook, Grady; Kubala, Kenny; Bates, Robert; Temple, Dorota; Lannon, John; Hilton, Allan; Glukh, Konstantin; Hardy, Busbee

    2013-06-01

    The DRS Tamarisk® 320 camera, introduced in 2011, is a low cost commercial camera based on the 17 µm pixel pitch 320×240 VOx microbolometer technology. A higher resolution 17 µm pixel pitch 640×480 Tamarisk®640 has also been developed and is now in production serving the commercial markets. Recently, under the DARPA sponsored Low Cost Thermal Imager-Manufacturing (LCTI-M) program and internal project, DRS is leading a team of industrial experts from FiveFocal, RTI International and MEMSCAP to develop a small form factor uncooled infrared camera for the military and commercial markets. The objective of the DARPA LCTI-M program is to develop a low SWaP camera (costs less than US $500 based on a 10,000 units per month production rate. To meet this challenge, DRS is developing several innovative technologies including a small pixel pitch 640×512 VOx uncooled detector, an advanced digital ROIC and low power miniature camera electronics. In addition, DRS and its partners are developing innovative manufacturing processes to reduce production cycle time and costs including wafer scale optic and vacuum packaging manufacturing and a 3-dimensional integrated camera assembly. This paper provides an overview of the DRS Tamarisk® project and LCTI-M related uncooled technology development activities. Highlights of recent progress and challenges will also be discussed. It should be noted that BAE Systems and Raytheon Vision Systems are also participants of the DARPA LCTI-M program.

  18. AANtID: an alternative approach to network intrusion detection ...

    African Journals Online (AJOL)

    Journal of Computer Science and Its Application ... Security has become not just a feature of an information system, but the core and a necessity especially the systems that communicate and transmit data over the Internet for they are more ... Keywords: Intrusion, Genetic Algorithm, detection, Security, DARPA dataset ...

  19. New Dimensions in Microarchitecture Harnessing 3D Integration Technologies (BRIEFING CHARTS)

    Science.gov (United States)

    2007-03-06

    Quad Core Bandwidth and Latency Boundaries General Purpose Processor Loads Latency limited Ba nd w id th li m ite dProcessor load trade -off between I...delay No= number of ckts at 1V do= ckt delay at 1V From “3D Intergration ” Special Topic Sessionl W. Haensch, ISSCC ‘07, 2/07 11 DARPA MTS March 6, 2007

  20. Trusted Remote Operation of Proximate Emergy Robots (TROOPER): DARPA Robotics Challenge

    Science.gov (United States)

    2015-12-01

    method for activating the drill is to press the button by visual servoing in with the POKEY stick, described below. 3.3.5.4 Button Tracking and Stick...involving visual servoing much easier to accomplish. Figure 7. POKEY Stick Since the camera is mounted at a more maneuverable position (i.e., end...In the wall task, the cutting tool can be activated using a visual servoing approach to find the button with the hand camera then steadily move

  1. Trusted Remote Operation of Proximate Emergency Robots (TROOPER): DARPA Robotics Challenge

    Science.gov (United States)

    2015-12-01

    method for activating the drill is to press the button by visual servoing in with the POKEY stick, described below. 3.3.5.4 Button Tracking and Stick...involving visual servoing much easier to accomplish. Figure 7. POKEY Stick Since the camera is mounted at a more maneuverable position (i.e., end...In the wall task, the cutting tool can be activated using a visual servoing approach to find the button with the hand camera then steadily move

  2. Plan Recognition using Statistical Relational Models

    Science.gov (United States)

    2014-08-25

    corresponding undirected model can be significantly more complex since there is no closed form solution for the maximum-likelihood set of parameters unlike in...algorithm did not scale to larger training sets, and the overall results are still not competitive with BALPs. 5In directed models, a closed form solution...opinions of ARO, DARPA, NSF or any other government agency. References Albrecht DW, Zukerman I, Nicholson AE. Bayesian models for keyhole plan

  3. DARPA Emerging Technologies

    Science.gov (United States)

    2016-01-01

    American Security, April 2015), https://www.cnas.org/sites/default/files/ publica tions-pdf/CNAS_Directed_Energy_Weapons_April-2015.pdf. Disclaimer The views...and opinions expressed or implied in SSQ are those of the authors and are not officially sanctioned by any agency or department of the US

  4. Research Leading to High Throughput Processing of Thin-Film CdTe PV Module: Phase I Annual Report, October 2003 (Revised)

    Energy Technology Data Exchange (ETDEWEB)

    Powell, R. C.; Meyers, P. V.

    2004-02-01

    Work under this subcontract contributes to the overall manufacturing operation. During Phase I, average module efficiency on the line was improved from 7.1% to 7.9%, due primarily to increased photocurrent resulting from a decrease in CdS thickness. At the same time, production volume for commercial sale increased from 1.5 to 2.5 MW/yr. First Solar is committed to commercializing CdTe-based thin-film photovoltaics. This commercialization effort includes a major addition of floor space and equipment, as well as process improvements to achieve higher efficiency and greater durability. This report presents the results of Phase I of the subcontract entitled''Research Leading to High Throughput Processing of Thin-Film CdTe PV Modules.'' The subcontract supports several important aspects needed to begin high-volume manufacturing, including further development of the semiconductor deposition reactor, advancement of accelerated life testing methods and understanding, and improvements to th e environmental, health, and safety programs. Progress in the development of the semiconductor deposition reactor was made in several areas. First, a new style of vapor transport deposition distributor with simpler operational behavior and the potential for improved cross-web uniformity was demonstrated. Second, an improved CdS feed system that will improve down-web uniformity was developed. Third, the core of a numerical model of fluid and heat flow within the distributor was developed, including flow in a 3-component gas system at high temperature and low pressure and particle sublimation.

  5. Managing complexity practical considerations in the development and application of ABMs to contemporary policy challenges

    CERN Document Server

    O’Brien, Sean; Khouja, Moutaz

    2013-01-01

    This book emerged out of a project initiated and funded by the Defense Advanced Research Projects Agency (DARPA) that sought to build on efforts to transform agent-based models into platforms for predicting and evaluating policy responses to real world challenges around the world.  It began with the observation that social science theories of human behavior are often used to estimate the consequences of alternative policy responses to important issues and challenges.  However, alternative theories that remain subject to contradictory claims are ill suited to inform policy. The vision behind the DARPA project was to mine the social sciences literature for alternative theories of human behavior, and then formalize, instantiate, and integrate them within the context of an agent-based modeling system.  The research team developed an experimental platform to evaluate the conditions under which alternative theories and groups of theories applied.  The end result was a proof of concept—developed from the groun...

  6. Mechanistic spatio-temporal point process models for marked point processes, with a view to forest stand data

    DEFF Research Database (Denmark)

    Møller, Jesper; Ghorbani, Mohammad; Rubak, Ege Holger

    We show how a spatial point process, where to each point there is associated a random quantitative mark, can be identified with a spatio-temporal point process specified by a conditional intensity function. For instance, the points can be tree locations, the marks can express the size of trees......, and the conditional intensity function can describe the distribution of a tree (i.e., its location and size) conditionally on the larger trees. This enable us to construct parametric statistical models which are easily interpretable and where likelihood-based inference is tractable. In particular, we consider maximum...

  7. 2011 Marine Corps Systems Command Small Business Opportunities Conference Held in Fredericksburg, Virginia on December 14, 2011

    Science.gov (United States)

    2011-12-14

    Teammates per Prime: 29 • Primes: TCG, CTC, DTI , EDO, INS/LM, L-3, Logis-Tech, Thomas Assoc. , URS...terrains S-MET Program Matures payload carrying and dismount following capabilities DARPA LS3 System A legged robot with improved mobility over irregular...to ride upon more difficult terrains at higher speeds. Legged robots have continued to improve through research. The DARPA Legged Squad Support

  8. Construct Validity in TOEFL iBT Speaking Tasks: Insights from Natural Language Processing

    Science.gov (United States)

    Kyle, Kristopher; Crossley, Scott A.; McNamara, Danielle S.

    2016-01-01

    This study explores the construct validity of speaking tasks included in the TOEFL iBT (e.g., integrated and independent speaking tasks). Specifically, advanced natural language processing (NLP) tools, MANOVA difference statistics, and discriminant function analyses (DFA) are used to assess the degree to which and in what ways responses to these…

  9. Testing and evaluation of a wearable augmented reality system for natural outdoor environments

    Science.gov (United States)

    Roberts, David; Menozzi, Alberico; Cook, James; Sherrill, Todd; Snarski, Stephen; Russler, Pat; Clipp, Brian; Karl, Robert; Wenger, Eric; Bennett, Matthew; Mauger, Jennifer; Church, William; Towles, Herman; MacCabe, Stephen; Webb, Jeffrey; Lupo, Jasper; Frahm, Jan-Michael; Dunn, Enrique; Leslie, Christopher; Welch, Greg

    2013-05-01

    This paper describes performance evaluation of a wearable augmented reality system for natural outdoor environments. Applied Research Associates (ARA), as prime integrator on the DARPA ULTRA-Vis (Urban Leader Tactical, Response, Awareness, and Visualization) program, is developing a soldier-worn system to provide intuitive `heads-up' visualization of tactically-relevant geo-registered icons. Our system combines a novel pose estimation capability, a helmet-mounted see-through display, and a wearable processing unit to accurately overlay geo-registered iconography (e.g., navigation waypoints, sensor points of interest, blue forces, aircraft) on the soldier's view of reality. We achieve accurate pose estimation through fusion of inertial, magnetic, GPS, terrain data, and computer-vision inputs. We leverage a helmet-mounted camera and custom computer vision algorithms to provide terrain-based measurements of absolute orientation (i.e., orientation of the helmet with respect to the earth). These orientation measurements, which leverage mountainous terrain horizon geometry and mission planning landmarks, enable our system to operate robustly in the presence of external and body-worn magnetic disturbances. Current field testing activities across a variety of mountainous environments indicate that we can achieve high icon geo-registration accuracy (<10mrad) using these vision-based methods.

  10. Controlled air incinerator for radioactive waste. Volume I. Rationale, process, equipment, performance, and recommendations

    International Nuclear Information System (INIS)

    Neuls, A.S.; Draper, W.E.; Koenig, R.A.; Newmyer, J.M.; Warner, C.L.

    1982-11-01

    This two-volume report is a detailed design and operating documentation of the Los Alamos National Laboratory Controlled Air Incinerator (CAI) and is an aid to technology transfer to other Department of Energy contractor sites and the commercial sector. Volume I describes the CAI process, equipment, and performance, and it recommends modifications based on Los Alamos experience. It provides the necessary information for conceptual design and feasibility studies. Volume II provides descriptive engineering information such as drawings specifications, calculations, and costs. It aids duplication of the process at other facilities

  11. Modeling of Embedded Human Systems

    Science.gov (United States)

    2013-07-01

    ISAT study [7] for DARPA in 20051 concretized the notion of an embedded human, who is a necessary component of the system. The proposed work integrates...Technology, IEEE Transactions on, vol. 16, no. 2, pp. 229–244, March 2008. [7] C. J. Tomlin and S. S. Sastry, “Embedded humans,” tech. rep., DARPA ISAT

  12. Search for a pentaquark decaying to <i>pK>0S in <i>γN>

    Energy Technology Data Exchange (ETDEWEB)

    Link, J. M.; Yager, P. M.; Anjos, J. C.; Bediaga, I.; Castromonte, C.; Machado, A. A.; Magnin, J.; Massafferri, A.; de Miranda, J. M.; Pepe, I. M.; Polycarpo, E.; dos Reis, A. C.; Carrillo, S.; Casimiro, E.; Cuautle, E.; Sánchez-Hernández, A.; Uribe, C.; Vázquez, F.; Agostino, L.; Cinquini, L.; Cumalat, J. P.; Frisullo, V.; O' Reilly, B.; Segoni, I.; Stenson, K.; Butler, J. N.; Cheung, H. W. K.; Chiodini, G.; Gaines, I.; Garbincius, P. H.; Garren, L. A.; Gottschalk, E.; Kasper, P. H.; Kreymer, A. E.; Kutschke, R.; Wang, M.; Benussi, L.; Bertani, M.; Bianco, S.; Fabbri, F. L.; Pacetti, S.; Zallo, A.; Reyes, M.; Cawlfield, C.; Kim, D. Y.; Rahimi, A.; Wiss, J.; Gardner, R.; Kryemadhi, A.; Chung, Y. S.; Kang, J. S.; Ko, B. R.; Kwak, J. W.; Lee, K. B.; Cho, K.; Park, H.; Alimonti, G.; Barberis, S.; Boschini, M.; Cerutti, A.; D' Angelo, P.; DiCorato, M.; Dini, P.; Edera, L.; Erba, S.; Inzani, P.; Leveraro, F.; Malvezzi, S.; Menasce, D.; Mezzadri, M.; Moroni, L.; Pedrini, D.; Pontoglio, C.; Prelz, F.; Rovere, M.; Sala, S.; Davenport, T. F.; Arena, V.; Boca, G.; Bonomi, G.; Gianini, G.; Liguori, G.; Lopes Pegna, D.; Merlo, M. M.; Pantea, D.; Ratti, S. P.; Riccardi, C.; Vitulo, P.; Göbel, C.; Olatora, J.; Hernandez, H.; Lopez, A. M.; Mendez, H.; Paris, A.; Quinones, J.; Ramirez, J. E.; Zhang, Y.; Wilson, J. R.; Handler, T.; Mitchell, R.; Engh, D.; Givens, K. M.; Hosack, M.; Johns, W. E.; Luiggi, E.; Nehring, M.; Sheldon, P. D.; Vaandering, E. W.; Webster, M.; Sheaff, M.

    2006-08-01

    We present a search for a pentaquark decaying strongly to <i>pK>0S in <i>γN> collisions at a center-of-mass energy up to 25 GeV/c2. Finding no evidence for such a state in the mass range of 1470 MeV/c2 to 2200 MeV/c2, we set limits on the yield and on the cross section times branching ratio relative to Σ* (1385)± and K* (892) +.

  13. Equipment and obtention process of {sup 131}I by dry distillation starting from TeO{sub 2}; Equipo y proceso de obtencion de {sup 131}I por destilacion seca a partir de TeO{sub 2}

    Energy Technology Data Exchange (ETDEWEB)

    Alanis M, J. [ININ, Departamento de Materiales Radiactivos, 52045 Ocoyoacac, Estado de Mexico (Mexico)

    2000-08-15

    The present invention refers to an equipment and process for the obtaining of {sup 131}I by dry distillation starting from TeO{sub 2} that has three interconnected systems, the manipulation system, the electric system and the distillation system, the combination of these systems, allows to improve the yield and the separation of the {sup 131}I during the distillation process, since inside the electric system it is an oven that has a special design based on a temperature gradient. The more relevant aspects of the equipment its are the design of each one of its components that give as result the effectiveness of the production of {sup 131}I in routinary form (industrial) whose final product can end up reaching a radiochemical purity up to 99% and a radionuclide purity of approximately 100%. The object of this invention is to provide a distillation equipment different to those that at the moment exist, thanks to its novel internal construction whose main characteristics already gather advantages on those existent. The reaction of obtaining of the TeO{sub 2}, the development of the technique and studies of TeO{sub 2} sintering and the irradiation experiments, its contributed to characterize with more precision the 'new process of obtaining of {sup 131}I by dry via starting from the Te' developed in the ININ, and in this way it was achieved a more pure product, more economic, with less risks, from a point of view of Radiological Safety and mainly that it avoids the import to the country and it makes to self-sufficient Mexico in the production of {sup 131}I. (Author)

  14. Equipment and obtention process of {sup 131}I by dry distillation starting from TeO{sub 2}; Equipo y proceso de obtencion de {sup 131}I por destilacion seca a partir de TeO{sub 2}

    Energy Technology Data Exchange (ETDEWEB)

    Alanis M, J [ININ, Departamento de Materiales Radiactivos, 52045 Ocoyoacac, Estado de Mexico (Mexico)

    2000-08-15

    The present invention refers to an equipment and process for the obtaining of {sup 131}I by dry distillation starting from TeO{sub 2} that has three interconnected systems, the manipulation system, the electric system and the distillation system, the combination of these systems, allows to improve the yield and the separation of the {sup 131}I during the distillation process, since inside the electric system it is an oven that has a special design based on a temperature gradient. The more relevant aspects of the equipment its are the design of each one of its components that give as result the effectiveness of the production of {sup 131}I in routinary form (industrial) whose final product can end up reaching a radiochemical purity up to 99% and a radionuclide purity of approximately 100%. The object of this invention is to provide a distillation equipment different to those that at the moment exist, thanks to its novel internal construction whose main characteristics already gather advantages on those existent. The reaction of obtaining of the TeO{sub 2}, the development of the technique and studies of TeO{sub 2} sintering and the irradiation experiments, its contributed to characterize with more precision the 'new process of obtaining of {sup 131}I by dry via starting from the Te' developed in the ININ, and in this way it was achieved a more pure product, more economic, with less risks, from a point of view of Radiological Safety and mainly that it avoids the import to the country and it makes to self-sufficient Mexico in the production of {sup 131}I. (Author)

  15. The theory of stochastic processes I

    CERN Document Server

    Gihman, Iosif Il’ich

    2004-01-01

    From the Reviews: "Gihman and Skorohod have done an excellent job of presenting the theory in its present state of rich imperfection." D.W. Stroock in Bulletin of the American Mathematical Society, 1980 "To call this work encyclopedic would not give an accurate picture of its content and style. Some parts read like a textbook, but others are more technical and contain relatively new results. ... The exposition is robust and explicit, as one has come to expect of the Russian tradition of mathematical writing. The set when completed will be an invaluable source of information and reference in this ever-expanding field" K.L. Chung in American Scientist, 1977 "..., the subject has grown enormously since 1953, and there will never be a true successor to Doob's book, but Gihman and Skorohod's three volumes will, I think, occupy a rather similar position as an invaluable tool of reference for all probability theorists. ... The dominant impression is of the authors' mastery of their material, and of their confident i...

  16. High-Performance Corrosion-Resistant Materials: Iron-Based Amorphous-Metal Thermal-Spray Coatings: SAM HPCRM Program ? FY04 Annual Report ? Rev. 0 - DARPA DSO & DOE OCRWM Co-Sponsored Advanced Materials Program

    Energy Technology Data Exchange (ETDEWEB)

    Farmer, J; Haslam, J; Wong, F; Ji, S; Day, S; Branagan, D; Marshall, M; Meacham, B; Buffa, E; Blue, C; Rivard, J; Beardsley, M; Buffa, E; Blue, C; Rivard, J; Beardsley, M; Weaver, D; Aprigliano, L; Kohler, L; Bayles, R; Lemieux, E; Wolejsza, T; Martin, F; Yang, N; Lucadamo, G; Perepezko, J; Hildal, K; Kaufman, L; Heuer, A; Ernst, F; Michal, G; Kahn, H; Lavernia, E

    2007-09-19

    The multi-institutional High Performance Corrosion Resistant Materials (HPCRM) Team is cosponsored by the Defense Advanced Projects Agency (DARPA) Defense Science Office (DSO) and the Department of Energy (DOE) Office of Civilian Radioactive Waste Management (OCRWM), and has developed new corrosion-resistant, iron-based amorphous metals that can be applied as coatings with advanced thermal spray technology. Two compositions have corrosion resistance superior to wrought nickel-based Alloy C-22 (UNS No. N06022) in very aggressive environments, including concentrated calcium-chloride brines at elevated temperature. Corrosion costs the Department of Defense billions of dollars every year, with an immense quantity of material in various structures undergoing corrosion. For example, in addition to fluid and seawater piping, ballast tanks, and propulsions systems, approximately 345 million square feet of structure aboard naval ships and crafts require costly corrosion control measures. The use of advanced corrosion-resistant materials to prevent the continuous degradation of this massive surface area would be extremely beneficial. The Fe-based corrosion-resistant, amorphous-metal coatings under development may prove of importance for applications on ships. Such coatings could be used as an 'integral drip shield' on spent fuel containers, as well as protective coatings that could be applied over welds, thereby preventing exposure to environments that might cause stress corrosion cracking. In the future, such new high-performance iron-based materials could be substituted for more-expensive nickel-based alloys, thereby enabling a reduction in the $58-billion life cycle cost for the long-term storage of the Nation's spent nuclear fuel by tens of percent.

  17. Administrative Candidacy: A Process of New-Role Learning--Part I

    Science.gov (United States)

    Greenfield, William D., Jr.

    1977-01-01

    Reports the initial results of a longitudinal study of the organizational socialization of educational administrators. Part I claims that socialization through the life-cycle may be conceived as a series of learned interpersonal relationships through which individuals build up a repertoire of interpersonal responses that condition new…

  18. iPSCs: A Minireview from Bench to Bed, including Organoids and the CRISPR System

    Directory of Open Access Journals (Sweden)

    Andrés Javier Orqueda

    2016-01-01

    Full Text Available When Dolly the sheep was born, the first probe into an adult mammalian genome traveling back in time and generating a whole new animal appeared. Ten years later, the reprogramming process became a defined method of producing induced pluripotent stem cells (iPSCs through the overexpression of four transcription factors. iPSCs are capable of originating virtually all types of cells and tissues, including a whole new animal. The reprogramming strategies based on patient-derived cells should make the development of clinical applications of cell based therapy much more straightforward. Here, we analyze the current state, opportunities, and challenges of iPSCs from bench to bed, including organoids and the CRISPR system.

  19. The iFlow modelling framework v2.4 : A modular idealized process-based model for flow and transport in estuaries

    NARCIS (Netherlands)

    Dijkstra, Y.M.; Brouwer, R.L.; Schuttelaars, H.M.; Schramkowski, G.P.

    2017-01-01

    The iFlow modelling framework is a width-averaged model for the systematic analysis of the water motion and sediment transport processes in estuaries and tidal rivers. The distinctive solution method, a mathematical perturbation method, used in the model allows for identification of the effect of

  20. Thermoactivation processes in PbI2:Zr and PbI2 crystals

    International Nuclear Information System (INIS)

    Panasyuk, M.R.; Kapustyanik, V.B.; Tsibul's'kij, V.S.; Dubov, Yu.G.; Pasternak, R.M.

    2007-01-01

    The X-ray luminescence, thermal emission and thermally stimulated depolarisation spectra as well as the influence of IR-illumination on the thermal emission and thermally stimulated depolarisation spectra of the PbI 2 :Zr and PbI 2 crystals have been studied. There were found the hole traps in the PbI 2 :Zr crystals that are absent in PbI 2 . For the observed traps the activation energy has been calculated. The mechanisms describing the traps' nature and that of thermally stimulated depolarisation currents have been proposed

  1. Modernization of I and C: A stepwise learning process with a final vision

    International Nuclear Information System (INIS)

    Gemst, P. van

    1998-01-01

    In spite of some political signals it is expected that the life time of nuclear power plants in the Nordic countries will be as designed for. As the economical life time of the I and C equipment is less than the corresponding life time of the plant a strategy for modernization of it must be developed. To modernize equipment during ongoing operation of the plant is not only a technical challenge but also a challenge to human relations. I will give a unique chance for the old generation, who built the plants, and the young generation, who have to modernize the plants, to discuss common problems and new ideas. The purpose of this paper is to summarize some important aspects which can be included in the content of the planned IAEA book. Furthermore some examples of modernization project in Sweden are given. (author)

  2. Speed and Agility: How Defense Acquisition Can Enable Innovation

    Science.gov (United States)

    2016-04-30

    Accelerators such as Y Combinator enable speed to market via a defined schedule. Y Combinator alone funded over 1,000 startups with a combined valuation ...of over $65 billion. Rapid Acquisition Organizations Acquisition executives, policy-makers, and process owners can learn from both Silicon Valley ...traits and organizational culture of the successful organizations. DARPA, Silicon Valley , and many other government and commercial organizations have

  3. Think-Aloud Process Superior to Thought-Listing in Increasing Children's Critical Processing of Advertising

    Science.gov (United States)

    Rozendaal, Esther; Buijzen, Moniek; Valkenburg, Patti M.

    2012-01-01

    This study develops and tests a model of children's critical processing of advertising. Within this model, 2 paths to reduced advertising susceptibility (i.e., attitude toward the advertised brand) were hypothesized: a cognitive path and an affective path. The secondary aim was to compare these paths for different thought verbalization processes:…

  4. DARPA 7-Day Challenge

    Science.gov (United States)

    2014-03-17

    Thimma, J.; Kumuthaa, M.; Sekarana, S.; Vadivelua, J. In 13th International Congress on Infectious Diseases; Elsevier Ltd.: Kuala Lumpur, Malaysia , 2008...S. A.; Ventura, V. V.; Qazi, O.; Harding, S. V.; Kitto, G. B.; Estes, D. M.; Dell , A.; Titball, R. W.; Atkins, T. P.; Brown, K. A.; Hitchen, P. G

  5. Electroless Sliver-Plating Process in the Preparation of 103Pd-125I Hybrid Brachytherapy Seed Cores

    Directory of Open Access Journals (Sweden)

    LI Zhong-yong1,2;CHEN Bin-da1;Lv Xiao-zhou1;LU Jin-hui1;CUI Hai-ping1,2

    2014-02-01

    Full Text Available Electroless 103Pd plating and electroless Ag plating and chemical 125I depositing were took place on the surface of carbon rods in turn, which was a reliable method for the preparation of 103Pd-125I hybrid brachytherapy seed cores. 103Pd and 125I were deposited on the same substrate effectively through silver coating as a bridge. The process of electroless Ag plating was a novel and important step in the preparation of 103Pd-125I hybrid seed. In this work, the process of electroless Ag plating was studied using 0.5×3.0 mm carbon rods with palladium coating as substrate, silver-ammino complex as precursor, 110mAg as radioactive tracer, and hydrazine as reductant. The optimum conditions were AgNO3 2g/L,Na2EDTA 40 g/L,NH3•H2O 16.25%,H4N2•H2O 5‰,pH=10,t=60 min,and T=35 ℃. Sliver deposited on each carbon rod was uniform, and sliver-coating was white and smooth.

  6. Computational Cognition and Robust Decision Making

    Science.gov (United States)

    2013-03-06

    much more powerful neuromorphic chips than current state of the art. L. Chua 10 DISTRIBUTION STATEMENT A – Unclassified, Unlimited Distribution 2...Cognition Program DARPA (Gill Pratt) • Systems of Neuromorphic Adaptive Plastic Scalable Electronics (SyNAPSE) Program IARPA (Brad Minnery...2012 - Four projects at SNU and KAIST co-funded with AOARD DARPA SyNAPSE Program: - Design, fabrication, and demonstration of neuromorphic

  7. A Lightweight I/O Scheme to Facilitate Spatial and Temporal Queries of Scientific Data Analytics

    Science.gov (United States)

    Tian, Yuan; Liu, Zhuo; Klasky, Scott; Wang, Bin; Abbasi, Hasan; Zhou, Shujia; Podhorszki, Norbert; Clune, Tom; Logan, Jeremy; Yu, Weikuan

    2013-01-01

    In the era of petascale computing, more scientific applications are being deployed on leadership scale computing platforms to enhance the scientific productivity. Many I/O techniques have been designed to address the growing I/O bottleneck on large-scale systems by handling massive scientific data in a holistic manner. While such techniques have been leveraged in a wide range of applications, they have not been shown as adequate for many mission critical applications, particularly in data post-processing stage. One of the examples is that some scientific applications generate datasets composed of a vast amount of small data elements that are organized along many spatial and temporal dimensions but require sophisticated data analytics on one or more dimensions. Including such dimensional knowledge into data organization can be beneficial to the efficiency of data post-processing, which is often missing from exiting I/O techniques. In this study, we propose a novel I/O scheme named STAR (Spatial and Temporal AggRegation) to enable high performance data queries for scientific analytics. STAR is able to dive into the massive data, identify the spatial and temporal relationships among data variables, and accordingly organize them into an optimized multi-dimensional data structure before storing to the storage. This technique not only facilitates the common access patterns of data analytics, but also further reduces the application turnaround time. In particular, STAR is able to enable efficient data queries along the time dimension, a practice common in scientific analytics but not yet supported by existing I/O techniques. In our case study with a critical climate modeling application GEOS-5, the experimental results on Jaguar supercomputer demonstrate an improvement up to 73 times for the read performance compared to the original I/O method.

  8. Coupling the modular helium reactor to hydrogen production processes

    International Nuclear Information System (INIS)

    Richards, M.B.; Shenoy, A.S.; Schultz, K.R.

    2004-01-01

    Steam reforming of natural gas (methane) currently produces the bulk of hydrogen gas used in the world today. Because this process depletes natural gas resources and generates the greenhouse gas carbon dioxide as a by-product, there is a growing interest in using process heat and/or electricity generated by nuclear reactors to generate hydrogen by splitting water. Process heat from a high temperature nuclear reactor can be used directly to drive a set of chemical reactions, with the net result of splitting water into hydrogen and oxygen. For example, process heat at temperatures in the range 850 deg C to 950 deg C can drive the sulphur-iodine (S-I) thermochemical process to produce hydrogen with high efficiency. The S-I process produces highly pure hydrogen and oxygen, with formation, decomposition, regeneration, and recycle of the intermediate chemical reagents. Electricity can also 1)e used directly to split water, using conventional, low-temperature electrolysis (LTE). Hydrogen can also be produced with hybrid processes that use both process heat and electricity to generate hydrogen. An example of a hybrid process is high-temperature electrolysis (HTE), in which process heat is used to generate steam, which is then supplied to an electrolyzer to generate hydrogen. This process is of interest because the efficiency of electrolysis increases with temperature. Because of its high temperature capability, advanced stage of development relative to other high-temperature reactor concepts, and passive-safety features, the modular helium reactor (MHR) is well suited for producing hydrogen using nuclear energy. In this paper we investigate the coupling of the MHR to the S-I process, LTE, and HTE. These concepts are referred to as the H2-MHR. (author)

  9. DARPA Quantum Network Testbed

    Science.gov (United States)

    2007-07-01

    Antonio Bovino, Pietro Varisco, Anna Maria Colla, Giuseppe Castagnoli, Giovanni Di Giuseppe and Alexander V. Sergienko “Effective Fiber-Coupling of...Giovanni Di Giuseppe Brian Imhausen Harvard University Teammate John Myers Tai Wu Leo Donnelly NIST Teammate Sae Woo Nam Bob Schwall Robert...A. M. Colla, G. Castagnoli, G. Di Giuseppe, and A. V. Sergienko, “Practical Quantum Key Distribution Using Polarization Entangled States

  10. COMMENTARY: I'M ONLY TRYING TO HELP: A ROLE FOR INTERVENTIONS IN TEACHING LISTENING

    Directory of Open Access Journals (Sweden)

    Michael Rost

    2007-02-01

    Full Text Available In my work as an author and teacher trainer, I have the opportunity to travel around the world and talk to teachers in a variety of settings. Though I meet teachers with a range of backgrounds and a wide disparity of resources, I find that a few common themes come up whenever I talk with teachers about language teaching and technology. One of the familiar refrains is that most of us claim to lack the technological resources we feel we need to teach effectively. There’s always something new on the horizon that we feel we just have to have. Another recurring theme is the lament that most of our students just don’t seem to take advantage of the extra learning opportunities we present them anyway! Teachers want to help, but often feel under appreciated for their efforts. Personally, I have relished the ongoing advances in technology over the course of my teaching career. I started out as a secondary school teacher in Togo, West Africa with chalk – sometimes yellow or pink! – and a blackboard as my only teaching technology. When teachers express a sense of being overwhelmed by new technology, I sometimes talk about my own beginnings and also remind them of a few of Donald Norman’s principles of human-centered design. According to Norman (2004, for any new technology to be effective, it must be intuitively helpful and elegantly efficient. In the case of language teaching, this means the technology must – immediately and transparently – help us teach better than we do already. If it doesn’t, we simply shouldn’t use it. In addition, Norman says, for any new technology to be widely adopted, it must appeal to the emotions as well as to reason. If people don’t enjoy using a particular technology, no matter how logically useful it may be, they will tend to shun it. Perhaps because as language teachers we tend to favor eclecticism, we will often throw any emerging technology into the mix as a "helpful resource." As Doughty and Long (2003

  11. Akt inhibition promotes ABCA1-mediated cholesterol efflux to ApoA-I through suppressing mTORC1.

    Directory of Open Access Journals (Sweden)

    Fumin Dong

    Full Text Available ATP-binding cassette transporter A1 (ABCA1 plays an essential role in mediating cholesterol efflux to apolipoprotein A-I (apoA-I, a major housekeeping mechanism for cellular cholesterol homeostasis. After initial engagement with ABCA1, apoA-I directly interacts with the plasma membrane to acquire cholesterol. This apoA-I lipidation process is also known to require cellular signaling processes, presumably to support cholesterol trafficking to the plasma membrane. We report here that one of major signaling pathways in mammalian cells, Akt, is also involved. In several cell models that express ABCA1 including macrophages, pancreatic beta cells and hepatocytes, inhibition of Akt increases cholesterol efflux to apoA-I. Importantly, Akt inhibition has little effect on cells expressing non-functional mutant of ABCA1, implicating a specific role of Akt in ABCA1 function. Furthermore, we provide evidence that mTORC1, a major downstream target of Akt, is also a negative regulator of cholesterol efflux. In cells where mTORC1 is constitutively activated due to tuberous sclerosis complex 2 deletion, cholesterol efflux to apoA-I is no longer sensitive to Akt activity. This suggests that Akt suppresses cholesterol efflux through mTORC1 activation. Indeed, inhibition of mTORC1 by rapamycin or Torin-1 promotes cholesterol efflux. On the other hand, autophagy, one of the major pathways of cholesterol trafficking, is increased upon Akt inhibition. Furthermore, Akt inhibition disrupts lipid rafts, which is known to promote cholesterol efflux to apoA-I. We therefore conclude that Akt, through its downstream targets, mTORC1 and hence autophagy, negatively regulates cholesterol efflux to apoA-I.

  12. Essential iOS Build and Release A Comprehensive Guide to Building, Packaging, and Distribution

    CERN Document Server

    Roche, Ron

    2011-01-01

    Frustrated by the requirements for testing and distributing your iOS app? You're not alone. This concise book takes you step by step through the maze of certification and provisioning processes that have to happen before, during, and after development. You'll learn what's required to sign certificates, test your app on iOS devices, and release the finished product to the App Store. Whether you're a developer looking to spend more time coding and less time figuring out how to install your application, or a release engineer responsible for producing reliable builds, this guide will help you su

  13. Advanced pulse oximeter signal processing technology compared to simple averaging. I. Effect on frequency of alarms in the operating room.

    Science.gov (United States)

    Rheineck-Leyssius, A T; Kalkman, C J

    1999-05-01

    To determine the effect of a new signal processing technique (Oxismart, Nellcor, Inc., Pleasanton, CA) on the incidence of false pulse oximeter alarms in the operating room (OR). Prospective observational study. Nonuniversity hospital. 53 ASA physical status I, II, and III consecutive patients undergoing general anesthesia with tracheal intubation. In the OR we compared the number of alarms produced by a recently developed third generation pulse oximeter (Nellcor Symphony N-3000) with Oxismart signal processing technique and a conventional pulse oximeter (Criticare 504). Three pulse oximeters were used simultaneously in each patient: a Nellcor pulse oximeter, a Criticare with the signal averaging time set at 3 seconds (Criticareaverage3s) and a similar unit with the signal averaging time set at 21 seconds (Criticareaverage21s). For each pulse oximeter, the number of false (artifact) alarms was counted. One false alarm was produced by the Nellcor (duration 55 sec) and one false alarm by the Criticareaverage21s monitor (5 sec). The incidence of false alarms was higher in Criticareaverage3s. In eight patients, Criticareaverage3s produced 20 false alarms (p signal processing compared with the Criticare monitor with the longer averaging time of 21 seconds.

  14. Security Hardened Cyber Components for Nuclear Power Plants: Phase I SBIR Final Technical Report

    Energy Technology Data Exchange (ETDEWEB)

    Franusich, Michael D. [SpiralGen, Inc., Pittsburgh, PA (United States)

    2016-03-18

    SpiralGen, Inc. built a proof-of-concept toolkit for enhancing the cyber security of nuclear power plants and other critical infrastructure with high-assurance instrumentation and control code. The toolkit is based on technology from the DARPA High-Assurance Cyber Military Systems (HACMS) program, which has focused on applying the science of formal methods to the formidable set of problems involved in securing cyber physical systems. The primary challenges beyond HACMS in developing this toolkit were to make the new technology usable by control system engineers and compatible with the regulatory and commercial constraints of the nuclear power industry. The toolkit, packaged as a Simulink add-on, allows a system designer to assemble a high-assurance component from formally specified and proven blocks and generate provably correct control and monitor code for that subsystem.

  15. First-principles study on the initial decomposition process of CH3NH3PbI3

    Science.gov (United States)

    Xue, Yuanbin; Shan, Yueyue; Xu, Hu

    2017-09-01

    Hybrid perovskites are promising materials for high-performance photovoltaics. Unfortunately, hybrid perovskites readily decompose in particular under humid conditions, and the mechanisms of this phenomenon have not yet been fully understood. In this work, we systematically studied the possible mechanisms and the structural properties during the initial decomposition process of MAPbI3 (MA = CH3NH3+) using first-principles calculations. The theoretical results show that it is energetically favorable for PbI2 to nucleate and crystalize from the MAPbI3 matrix ahead of other decomposition products. Additionally, the structural instability is an intrinsic property of MAPbI3, regardless of whether the system is exposed to humidity. We find that H2O could facilitate the desorption of gaseous components, acting as a catalyst to transfer the H+ ion. These results provide insight into the cause of the instability of MAPbI3 and may improve our understanding of the properties of hybrid perovskites.

  16. High-Performance Corrosion-Resistant Materials: Iron-Based Amorphous-Metal Thermal-Spray Coatings: SAM HPCRM Program ? FY04 Annual Report ? Rev. 0 - DARPA DSO and DOE OCRWM Co-Sponsored Advanced Materials Program

    International Nuclear Information System (INIS)

    Farmer, J; Haslam, J; Wong, F; Ji, S; Day, S; Branagan, D; Marshall, M; Meacham, B; Buffa, E; Blue, C; Rivard, J; Beardsley, M; Buffa, E; Blue, C; Rivard, J; Beardsley, M; Weaver, D; Aprigliano, L; Kohler, L; Bayles, R; Lemieux, E; Wolejsza, T; Martin, F; Yang, N; Lucadamo, G; Perepezko, J; Hildal, K; Kaufman, L; Heuer, A; Ernst, F; Michal, G; Kahn, H; Lavernia, E

    2007-01-01

    The multi-institutional High Performance Corrosion Resistant Materials (HPCRM) Team is cosponsored by the Defense Advanced Projects Agency (DARPA) Defense Science Office (DSO) and the Department of Energy (DOE) Office of Civilian Radioactive Waste Management (OCRWM), and has developed new corrosion-resistant, iron-based amorphous metals that can be applied as coatings with advanced thermal spray technology. Two compositions have corrosion resistance superior to wrought nickel-based Alloy C-22 (UNS No. N06022) in very aggressive environments, including concentrated calcium-chloride brines at elevated temperature. Corrosion costs the Department of Defense billions of dollars every year, with an immense quantity of material in various structures undergoing corrosion. For example, in addition to fluid and seawater piping, ballast tanks, and propulsions systems, approximately 345 million square feet of structure aboard naval ships and crafts require costly corrosion control measures. The use of advanced corrosion-resistant materials to prevent the continuous degradation of this massive surface area would be extremely beneficial. The Fe-based corrosion-resistant, amorphous-metal coatings under development may prove of importance for applications on ships. Such coatings could be used as an 'integral drip shield' on spent fuel containers, as well as protective coatings that could be applied over welds, thereby preventing exposure to environments that might cause stress corrosion cracking. In the future, such new high-performance iron-based materials could be substituted for more-expensive nickel-based alloys, thereby enabling a reduction in the $58-billion life cycle cost for the long-term storage of the Nation's spent nuclear fuel by tens of percent

  17. <i>Acacia cyclopsi> A. Cunn. ex G. Don (Leguminosae in Italy: first cases of naturalization

    Directory of Open Access Journals (Sweden)

    Pasta, Salvatore

    2012-12-01

    Full Text Available The first two cases of naturalization of <i>Acacia cyclopsi> are reported for Italy. Young trees were observed growing in the wild some 15 years ago on Linosa (Pelagie Islands, Strait of Sicily. A decade later, this alien plant should no longer be considered as a casual, since a very intensive process of self-sown regeneration has been observed in some plantations on Lampedusa, the major island of the same Archipelago. The available literature suggests the need for careful monitoring of the ongoing invasion process, as <i>A. cyclopsi> has already shown a very invasive behaviour elsewhere within Mediterranean-type biomes due to its ability to withstand high environmental stresses. As migrating birds are suspected to have played an important role in facilitating the arrival of <i>A. cyclopsi>, further propagules are likely to reach the islands in the future. We recommend that new plantations of <i>A. cyclopsi> should be forbidden, but that extant naturalized populations should be managed instead of eradicating them. In fact, the effect of <i>Acacia> plantations warrants investigation at different scales in order to assess their impact on local plant-diversity and ecological succession processes.

    Se muestran los dos primeros casos de naturalización de <i>Acacia cyclopsi
    > para el territorio italiano. Se observó que las plántulas de este arbol crecen en forma silvestre hace unos 15 años en Linosa (islas Pelagias, estrecho de Sicilia. Una década después, ya no puede ser considerada una xenófita casual ya que se observó una regeneración muy intensa en algunos proyectos de reforestación en Lampedusa, la isla más grande del mismo archipiélago. Publicaciones anteriores sugieren la necesidad de un monitoreo cuidadoso del proceso de invasión en curso, ya que <i>A. cyclopsi> ha expresado un comportamiento altamente invasivo en otros biomas de tipo mediterráneo, debido a su alta tolerancia al estrés ambiental. Dado que se

  18. A viral, transporter associated with antigen processing (TAP)-independent, high affinity ligand with alternative interactions endogenously presented by the nonclassical human leukocyte antigen E class I molecule.

    Science.gov (United States)

    Lorente, Elena; Infantes, Susana; Abia, David; Barnea, Eilon; Beer, Ilan; García, Ruth; Lasala, Fátima; Jiménez, Mercedes; Mir, Carmen; Morreale, Antonio; Admon, Arie; López, Daniel

    2012-10-12

    The transporter associated with antigen processing (TAP) enables the flow of viral peptides generated in the cytosol by the proteasome and other proteases to the endoplasmic reticulum, where they complex with nascent human leukocyte antigen (HLA) class I. Later, these peptide-HLA class I complexes can be recognized by CD8(+) lymphocytes. Cancerous cells and infected cells in which TAP is blocked, as well as individuals with unusable TAP complexes, are able to present peptides on HLA class I by generating them through TAP-independent processing pathways. Here, we identify a physiologically processed HLA-E ligand derived from the D8L protein in TAP-deficient vaccinia virus-infected cells. This natural high affinity HLA-E class I ligand uses alternative interactions to the anchor motifs previously described to be presented on nonclassical HLA class I molecules. This octameric peptide was also presented on HLA-Cw1 with similar binding affinity on both classical and nonclassical class I molecules. In addition, this viral peptide inhibits HLA-E-mediated cytolysis by natural killer cells. Comparison between the amino acid sequences of the presenting HLA-E and HLA-Cw1 alleles revealed a shared structural motif in both HLA class molecules, which could be related to their observed similar cross-reactivity affinities. This motif consists of several residues located on the floor of the peptide-binding site. These data expand the role of HLA-E as an antigen-presenting molecule.

  19. A trajectory description of quantum processes. I. Fundamentals. A Bohmian perspective

    International Nuclear Information System (INIS)

    Sanz, Angel S.; Miret-Artes, Salvador

    2012-01-01

    Offers a thorough introduction to, and treatment of, trajectory-based quantum-mechanical calculations. Presents the fundamentals of Bohmian mechanics. Useful for a wide range of scattering problems, as described in Vol. 2. Trajectory-based formalisms are an intuitively appealing way of describing quantum processes because they allow the use of ''classical'' concepts. Beginning at an introductory level suitable for students, this two-volume monograph presents (1) the fundamentals and (2) the applications of the trajectory description of basic quantum processes. This first volume is focussed on the classical and quantum background necessary to understand the fundamentals of Bohmian mechanics, which can be considered the main topic of this work. Extensions of the formalism to the fields of open quantum systems and to optics are also proposed and discussed.

  20. A trajectory description of quantum processes. I. Fundamentals. A Bohmian perspective

    Energy Technology Data Exchange (ETDEWEB)

    Sanz, Angel S.; Miret-Artes, Salvador [Consejo Superior de Investigaciones Cientificas, Madrid (Spain). Inst. de Fisica Fundamental

    2012-11-01

    Offers a thorough introduction to, and treatment of, trajectory-based quantum-mechanical calculations. Presents the fundamentals of Bohmian mechanics. Useful for a wide range of scattering problems, as described in Vol. 2. Trajectory-based formalisms are an intuitively appealing way of describing quantum processes because they allow the use of ''classical'' concepts. Beginning at an introductory level suitable for students, this two-volume monograph presents (1) the fundamentals and (2) the applications of the trajectory description of basic quantum processes. This first volume is focussed on the classical and quantum background necessary to understand the fundamentals of Bohmian mechanics, which can be considered the main topic of this work. Extensions of the formalism to the fields of open quantum systems and to optics are also proposed and discussed.

  1. I-PFO: the new technology for simple and flexible implementation of high productive on-the-fly remote processes

    Science.gov (United States)

    Müllegger, Andreas; Ryba, Tracey

    2017-02-01

    Standardized production systems which can be implemented, programmed, maintained and sourced in a simple and efficient way are key for a successful global production of automobiles or related parts at component suppliers. This is also valid for systems, which are built by laser based processes. One of the key applications is remote laser welding (RLW) of "Body in White" (BIW) parts (such as hang-on parts, B-Pillars, side frames, etc.), but also builtin components (such as car seats, batteries, etc.). The majority of RLW applications are based on the implementation of a 3-D scanner optic (e.g. the PFO 3D from TRUMPF) which positions the laser beam on the various component surfaces to be welded. Over the past 10 years it has been proven that the most efficient way to build up the RLW process is to have a system where an industrial robot and a scanner optic are combined in one production cell. They usually cooperate within an "On-The-Fly" (OTF) process as this ensures minimum cycle times. Until now there are several technologies on the market which can coordinate both the robot and scanner in the OTF mode. But none of them meet all requirements of global standardized production solutions. With the introduction of the I-PFO (Intelligent Programmable Focusing Optics) technology the situation has changed. It is now possible to program or adopt complex remote processes in a fast and easy way by the "Teach-in" function via the robot teach pendant. Additionally a 3D offline designer software is an option for this system. It automatically creates the ideal remote process based on the part, fixture, production cell and required process parameters. The I-PFO technology doesn't need additional hardware due to the fact that it runs on the controller within the PFO 3D. Furthermore it works together with different types of industrial robots (e.g. ABB, Fanuc and KUKA) which allow highest flexibility for the production planning phase. Finally a single TRUMPF laser source can supply

  2. 'I left the NHS to start a business'.

    Science.gov (United States)

    Shaw, Sally

    2016-05-18

    It was December 2011. As I walked through the snow towards the hospital I'd worked at since I was 19, a feeling of despair came over me. I heard myself say out loud: 'I will not be doing this, this time next year.' It took me by surprise - it was not a question, it was a fact.

  3. Developing a univariate approach to phase-I monitoring of fuzzy quality profiles

    Directory of Open Access Journals (Sweden)

    Kazem Noghondarian

    2012-10-01

    Full Text Available In many real-world applications, the quality of a process or a particular product can be characterized by a functional relationship called profile. A profile builds the relationships between a response quality characteristic and one or more explanatory variables. Monitoring the quality of a profile is implemented to understand and to verify the stability of this functional relationship over time. In some real applications, a fuzzy linear regression model can represent the profile adequately where the response quality characteristic is fuzzy. The purpose of this paper is to develop an approach for monitoring process/product profiles in fuzzy environment. A model in fuzzy linear regression is developed to construct the quality profiles by using linear programming and then fuzzy individuals and moving-range (I-MR control charts are developed to monitor both intercept and slope of fuzzy profiles to achieve an in-control process. A case study in customer satisfaction is presented to show the application of our approach and to express the sensitivity analysis of parameters for building a fuzzy profile.

  4. DARPA TRADES Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    Aguilo Valentin, Miguel Alejandro [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Trujillo, Susie [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2018-02-01

    During calendar year 2017, Sandia National Laboratories (SNL) made strides towards developing an open portable design platform rich in highperformance computing (HPC) enabled modeling, analysis and synthesis tools. The main focus was to lay the foundations of the core interfaces that will enable plug-n-play insertion of synthesis optimization technologies in the areas of modeling, analysis and synthesis.

  5. Microwave processing of radioactive materials-I

    International Nuclear Information System (INIS)

    White, T.L.; Berry, J.B.

    1989-01-01

    This paper is the first of two papers that reviews the major past and present applications of microwave energy for processing radioactive materials, with particular emphasis on processing radioactive wastes. Microwave heating occurs through the internal friction produced inside a dielectric material when its molecules vibrate in response to an oscillating microwave field. For this presentation, we shall focus on the two FCC-approved microwave frequencies for industrial, scientific, and medical use, 915 and 2450 MHz. Also, because of space limitations, we shall postpone addressing plasma processing of hazardous wastes using microwave energy until a later date. 13 refs., 4 figs

  6. Head First iPhone and iPad Development A Learner's Guide to Creating Objective-C Applications for the iPhone and iPad

    CERN Document Server

    Pilone, Dan

    2011-01-01

    Let's say you have a killer app idea for iPhone and iPad. Where do you begin? Head First iPhone and iPad Development will help you get your first application up and running in no time. You'll not only learn how to design for Apple's devices, you'll also master the iPhone SDK tools -- including Interface Builder, Xcode, and Objective-C programming principles -- to make your app stand out. Whether you're a seasoned Mac developer who wants to jump into the App store, or someone with strong object-oriented programming skills but no Mac experience, this book is a complete learning experience for

  7. Understanding Quality in Process Modelling: Towards a Holistic Perspective

    Directory of Open Access Journals (Sweden)

    Jan Recker

    2007-09-01

    Full Text Available Quality is one of the main topics in current conceptual modelling research, as is the field of business process modelling. Yet, widely acknowledged academic contributions towards an understanding or measurement of business process model quality are limited at best. In this paper I argue that the development of methodical theories concerning the measurement or establishment of process model quality must be preceded by methodological elaborations on business process modelling. I further argue that existing epistemological foundations of process modelling are insufficient for describing all extrinsic and intrinsic traits of model quality. This in turn has led to a lack of holistic understanding of process modelling. Taking into account the inherent social and purpose-oriented character of process modelling in contemporary organizations I present a socio-pragmatic constructionist methodology of business process modelling and sketch out implications of this perspective towards an understanding of process model quality. I anticipate that, based on this research, theories can be developed that facilitate the evaluation of the ’goodness’ of a business process model.

  8. The reaction mechanism for dehydration process catalyzed by type I dehydroquinate dehydratase from Gram-negative Salmonella enterica

    Science.gov (United States)

    Yao, Yuan; Li, Ze-Sheng

    2012-01-01

    The fundamental reaction mechanism for the dehydration process catalyzed by type I dehydroquinate dehydratase from Gram-negative Salmonella enterica has been studied by density functional theory calculations. The results indicate that the dehydration process undergoes a two-step cis-elimination mechanism, which is different from the previously proposed one. The catalytic roles of both the highly conserved residue His143 and the Schiff base formed between the substrate and Lys170 have also been elucidated. The structural and mechanistic insight presented here may direct the design of type I dehydroquinate dehydratase enzyme inhibitors as non-toxic antimicrobials, anti-fungals, and herbicides.

  9. Information Processing Approaches to Cognitive Development

    Science.gov (United States)

    1988-07-01

    Craik . F.I.M., & Lockhart , R.S. (1972). Levels of processing : A framework for memory research. Journal of Verbal Learning and Verbal Behavior, 11...task at both levels of performance, then one would, in both cases, postulate systems that had the ability to process symbols at the microscopic level ...821760s and early 70s. (cf. Atkinson & Shiffrin. 1968: Craik & Lockhart . 1972: Norman, Rumelhart, & LNR, 1975). This architecture is comprised of several

  10. Occupational exposure to 99mTc and 131I in a radiopharmacy room

    International Nuclear Information System (INIS)

    Valle, Bruna P.; Cunha, Kenya Dias da; Sa, Lidia Vasconcellos de; Souza, Wanderson; Santos, Maristela; Medeiras, Geiza; Conceicao, Cirilo S.

    2009-01-01

    Brazil has about 310 nuclear medicine services and 90% of these services use Molybdenum/Technetium generators to prepare several radiopharmaceuticals to diagnostics; about 70% use also 131 I for diagnosis and therapy. These radionuclides are associated to compounds in liquid form and during the manipulation to prepare and administer the patient dose some radioactive airborne particle can be generated. As consequence the workers can be exposed to airborne particles in the respirable fraction containing 99m Tc and 131 I. The aim of this study is develop a simple and rapid method to verify if the exhaust systems installed in the SMN are efficient in preventing the inhalation of radionuclides airborne particles by workers. In order to estimate the occupational exposure a nuclear medicine service was selected and aerosol samples were collected using personal air sampler with a cyclone. The samples were analyzed using a germanium detector system and the 99m Tc and 131 I average concentrations were obtained as 16,6 ± 14,34 mBq/m 3 and 0.72 ± 0.36 mBq/m 3 , respectively. It was not observed a correlation among air concentration and total activity processed in laboratory. These results show that the worker inhales airborne particles containing 99m Tc and 131 I. (author)

  11. BCQ+: a body constitution questionnaire to assess Yang-Xu. Part I: establishment of a first final version through a Delphi process.

    Science.gov (United States)

    Su, Yi-Chang; Chen, Li-Li; Lin, Jun-Dai; Lin, Jui-Shan; Huang, Yi-Chia; Lai, Jim-Shoung

    2008-12-01

    Assessing an individual's level of Yang deficiency (Yang-Xu) by its manifestations is a frequent issue in traditional Chinese medicine (TCM) clinical trials. To this end, an objective, reliable and rigorous diagnostic tool is required. This study aimed to develop a first final version of the Yang-Xu Constitution Questionnaire. We conducted 3 steps to develop such an objective measurement tool: 1) the research team was formed and a panel of 26 experts was selected for the Delphi process; 2) items for the questionnaire were generated by literature review and a Delphi process; items were reworded into colloquial questions; face and content validity of the items were evaluated through a Delphi process again; 3) the difficulty of the questionnaire was evaluated in a pilot study with 81 subjects aged 20-60 years. The literature review retrieved 35 relevant items which matched the definition of 'constitution' and 'Yang-Xu'. After a first Delphi process, 22 items were retained and translated into colloquial questions. According to the second part of the Delphi process, the content validity index of each of the 22 questions ranged between 0.85-1. These 22 questions were evaluated by 81 subjects, 2 questions that were hard to tell the difference were combined; 3 questions were modified after the research team had discussed the participants' feedback. Finally, the questionnaire was established with 21 questions. This first final version of a questionnaire to assess Yang-Xu constitution with considerable face and content validity may serve as a basis to develop an advanced Yang-Xu questionnaire. 2008 S. Karger AG, Basel.

  12. Assessing the Potential of Societal Verification by Means of New Media

    Science.gov (United States)

    2014-01-01

    the Defense Advanced Research Projects Agency (DARPA) “Red Balloon Challenge” in 2009 by finding 10 tethered weather balloons scattered across the...Institute of Technology (MIT) managed to locate 10 weather balloons tethered at undisclosed locations across the continental United States in less than...suited for complex problem solving, and the 2009 Defense Advanced Research Projects Agency’s (DARPA) “Red Balloon Challenge” has already demonstrated

  13. I. Advances in NMR Signal Processing. II. Spin Dynamics in Quantum Dissipative Systems

    Energy Technology Data Exchange (ETDEWEB)

    Lin, Yung-Ya [Univ. of California, Berkeley, CA (United States)

    1998-11-01

    Part I. Advances in IVMR Signal Processing. Improvements of sensitivity and resolution are two major objects in the development of NMR/MRI. A signal enhancement method is first presented which recovers signal from noise by a judicious combination of a priordmowledge to define the desired feasible solutions and a set theoretic estimation for restoring signal properties that have been lost due to noise contamination. The effect of noise can be significantly mitigated through the process of iteratively modifying the noisy data set to the smallest degree necessary so that it possesses a collection of prescribed properties and also lies closest to the original data set. A novel detection-estimation scheme is then introduced to analyze noisy and/or strongly damped or truncated FIDs. Based on exponential modeling, the number of signals is detected based on information estimated using the matrix pencil method. theory and the spectral parameters are Part II. Spin Dynamics in body dipole-coupled systems Quantum Dissipative Systems. Spin dynamics in manyconstitutes one of the most fundamental problems in magnetic resonance and condensed-matter physics. Its many-spin nature precludes any rigorous treatment. ‘Therefore, the spin-boson model is adopted to describe in the rotating frame the influence of the dipolar local fields on a tagged spin. Based on the polaronic transform and a perturbation treatment, an analytical solution is derived, suggesting the existence of self-trapped states in the. strong coupling limit, i.e., when transverse local field >> longitudinal local field. Such nonlinear phenomena originate from the joint action of the lattice fluctuations and the reaction field. Under semiclassical approximation, it is found that the main effect of the reaction field is the renormalization of the Hamiltonian of interest. Its direct consequence is the two-step relaxation process: the spin is initially localized in a quasiequilibrium state, which is later detrapped by

  14. EVOLUTION IN THE H I GAS CONTENT OF GALAXY GROUPS: PRE-PROCESSING AND MASS ASSEMBLY IN THE CURRENT EPOCH

    Energy Technology Data Exchange (ETDEWEB)

    Hess, Kelley M. [Astrophysics, Cosmology and Gravity Centre (ACGC), Department of Astronomy, University of Cape Town, Rondebosch 7701 (South Africa); Wilcots, Eric M., E-mail: hess@ast.uct.ac.za, E-mail: ewilcots@astro.wisc.edu [Department of Astronomy, University of Wisconsin-Madison, Madison, WI 53706 (United States)

    2013-11-01

    We present an analysis of the neutral hydrogen (H I) content and distribution of galaxies in groups as a function of their parent dark matter halo mass. The Arecibo Legacy Fast ALFA survey α.40 data release allows us, for the first time, to study the H I properties of over 740 galaxy groups in the volume of sky common to the Sloan Digital Sky Survey (SDSS) and ALFALFA surveys. We assigned ALFALFA H I detections a group membership based on an existing magnitude/volume-limited SDSS Data Release 7 group/cluster catalog. Additionally, we assigned group ''proximity' membership to H I detected objects whose optical counterpart falls below the limiting optical magnitude—thereby not contributing substantially to the estimate of the group stellar mass, but significantly to the total group H I mass. We find that only 25% of the H I detected galaxies reside in groups or clusters, in contrast to approximately half of all optically detected galaxies. Further, we plot the relative positions of optical and H I detections in groups as a function of parent dark matter halo mass to reveal strong evidence that H I is being processed in galaxies as a result of the group environment: as optical membership increases, groups become increasingly deficient of H I rich galaxies at their center and the H I distribution of galaxies in the most massive groups starts to resemble the distribution observed in comparatively more extreme cluster environments. We find that the lowest H I mass objects lose their gas first as they are processed in the group environment, and it is evident that the infall of gas rich objects is important to the continuing growth of large scale structure at the present epoch, replenishing the neutral gas supply of groups. Finally, we compare our results to those of cosmological simulations and find that current models cannot simultaneously predict the H I selected halo occupation distribution for both low and high mass halos.

  15. A screening procedure to evaluate air pollution effects on Class I wilderness areas

    Science.gov (United States)

    Douglas G. Fox; Ann M. Bartuska; James G. Byrne; Ellis Cowling; Richard Fisher; Gene E. Likens; Steven E. Lindberg; Rick A. Linthurst; Jay Messer; Dale S. Nichols

    1989-01-01

    This screening procedure is intended to help wilderness managers conduct "adverse impact determinations" as part of Prevention of Significant Deterioration (PSD) applications for sources that emit air pollutants that might impact Class I wildernesses. The process provides an initial estimate of susceptibility to critical loadings for sulfur, nitrogen, and...

  16. The concentration of apolipoprotein A-I decreases during experimentally induced acute-phase processes in pigs

    DEFF Research Database (Denmark)

    Carpintero, R.; Pineiro, M.; Andres, M.

    2005-01-01

    In this work, apolipoprotein A-I (ApoA-I) was purified from pig sera. The responses of this protein after sterile inflammation and in animals infected with Actinobacillus pleuropneumoniae or Streptococcus suis were investigated. Decreases in the concentrations of ApoA-I, two to five times lower...

  17. Solution-processed inorganic copper(I) thiocyanate (CuSCN) hole transporting layers for efficient p–i–n perovskite solar cells

    KAUST Repository

    Zhao, Kui

    2015-08-27

    CuSCN is a highly transparent, highly stable, low cost and easy to solution process HTL that is proposed as a low cost replacement to existing organic and inorganic metal oxide hole transporting materials. Here, we demonstrate hybrid organic-inorganic perovskite-based p-i-n planar heterojunction solar cells using a solution-processed copper(I) thiocyanate (CuSCN) bottom hole transporting layer (HTL). CuSCN, with its high workfunction, increases the open circuit voltage (Voc) by 0.23 V to 1.06 V as compared with devices based on the well-known poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) (0.83 V), resulting in a superior power conversion efficiency (PCE) of 10.8% without any notable hysteresis. Photoluminescence measurements suggest a similar efficiency of charge transfer at HTL/perovskite interface as PEDOT:PSS. However, we observe more efficient light harvesting in the presence of CuSCN at shorter wavelengths despite PEDOT:PSS being more transparent. Further investigation of the microstructure and morphology reveals differences in the crystallographic texture of the polycrystalline perovskite film, suggesting somewhat modified perovskite growth on the surface of CuSCN. The successful demonstration of the solution-processed inorganic HTL using simple and low temperature processing routes bodes well for the development of reliable and efficient flexible p-i-n perovskite modules or for integration as a front cell in hybrid tandem solar cells.

  18. DARPA, SDI, and GaAs

    International Nuclear Information System (INIS)

    Karp, S.; Rooslid, S.

    1986-01-01

    When silicon replaced germanium in the early 1960's as the semiconductor of choice for solid state devices, it converted the entire industry in just a few years because of two important characteristics. First, silicon has a higher energy bandgap, which permits silicon-based devices to operate over a wider temperature range (a feature especially important to the military). Second, and more important, silicon has a native oxide that provided for improved stability and planar, rather than mesa, type devices. Planar technology soon spawned integrated circuits. The integrated circuit in turn brought on the electronics revolution, allowing the complexity of circuits to increase by a factor of two every year (Moore's Law) and bringing us from single transistors to megabit memory chips

  19. Batching alternatives for Phase I retrieval wastes to be processed in WRAP Module 1

    International Nuclear Information System (INIS)

    Mayancsik, B.A.

    1994-01-01

    During the next two decades, the transuranic (TRU) waste now stored in the 200 Area burial trenches and storage buildings is to be retrieved, processed in the Waste Receiving and Processing (WRAP) Module 1 facility, and shipped to a final disposal facility. The purpose of this document is to identify the criteria that can be used to batch suspect TRU waste, currently in retrievable storage, for processing through the WRAP Module 1 facility. These criteria are then used to generate a batch plan for Phase 1 Retrieval operations, which will retrieve the waste located in Trench 4C-04 of the 200 West Area burial ground. The reasons for batching wastes for processing in WRAP Module 1 include reducing the exposure of workers and the environment to hazardous material and ionizing radiation; maximizing the efficiency of the retrieval, processing, and disposal processes by reducing costs, time, and space throughout the process; reducing analytical sampling and analysis; and reducing the amount of cleanup and decontamination between process runs. The criteria selected for batching the drums of retrieved waste entering WRAP Module 1 are based on the available records for the wastes sent to storage as well as knowledge of the processes that generated these wastes. The batching criteria identified in this document include the following: waste generator; type of process used to generate or package the waste; physical waste form; content of hazardous/dangerous chemicals in the waste; radiochemical type and quantity of waste; drum weight; and special waste types. These criteria were applied to the waste drums currently stored in Trench 4C-04. At least one batching scheme is shown for each of the criteria listed above

  20. DARPA Ensemble-Based Modeling Large Graphs & Applications to Social Networks

    Science.gov (United States)

    2015-07-29

    such as gender , level of education, age, race, religion, etc. We want to design statistically sound experiments that allow us to correctly make...age” of a researcher, the widely differing citation conventions among different fields, and the co- authorship of researchers with differing h-indices

  1. Effect of closed-loop order processing on the time to initial antimicrobial therapy.

    Science.gov (United States)

    Panosh, Nicole; Rew, Richardd; Sharpe, Michelle

    2012-08-15

    The results of a study comparing the average time to initiation of i.v. antimicrobial therapy with closed-versus open-loop order entry and processing are reported. A retrospective cohort study was performed to compare order-to-administration times for initial doses of i.v. antimicrobials before and after a closed-loop order-processing system including computerized prescriber order entry (CPOE) was implemented at a large medical center. A total of 741 i.v. antimicrobial administrations to adult patients during designated five-month preimplementation and postimplementation study periods were assessed. Drug-use reports generated by the pharmacy database were used to identify order-entry times, and medication administration records were reviewed to determine times of i.v. antimicrobial administration. The mean ± S.D. order-to-administration times before and after the implementation of the CPOE system and closed-loop order processing were 3.18 ± 2.60 and 2.00 ± 1.89 hours, respectively, a reduction of 1.18 hours (p Closed-loop order processing was associated with significant reductions in the average time to initiation of i.v. therapy in all patient care areas evaluated (cardiology, general medicine, and oncology). The study results suggest that CPOE-based closed-loop order processing can play an important role in achieving compliance with current practice guidelines calling for increased efforts to ensure the prompt initiation of i.v. antimicrobials for severe infections (e.g., sepsis, meningitis). Implementation of a closed-loop order-processing system resulted in a significant decrease in order-to-administration times for i.v. antimicrobial therapy.

  2. FRPA: A Framework for Recursive Parallel Algorithms

    Science.gov (United States)

    2015-05-01

    Research (a member of STARnet, a Semiconductor Re- search Corporation program sponsored by MARCO and DARPA), and ASPIRE Lab industrial sponsors and af...filiates Intel, Google, Nokia, NVIDIA , and Oracle. Any opinions, findings, conclusions, or recommendations in this paper are solely those of the authors

  3. Prediction and assimilation of surf-zone processes using a Bayesian network: Part I: Forward models

    Science.gov (United States)

    Plant, Nathaniel G.; Holland, K. Todd

    2011-01-01

    Prediction of coastal processes, including waves, currents, and sediment transport, can be obtained from a variety of detailed geophysical-process models with many simulations showing significant skill. This capability supports a wide range of research and applied efforts that can benefit from accurate numerical predictions. However, the predictions are only as accurate as the data used to drive the models and, given the large temporal and spatial variability of the surf zone, inaccuracies in data are unavoidable such that useful predictions require corresponding estimates of uncertainty. We demonstrate how a Bayesian-network model can be used to provide accurate predictions of wave-height evolution in the surf zone given very sparse and/or inaccurate boundary-condition data. The approach is based on a formal treatment of a data-assimilation problem that takes advantage of significant reduction of the dimensionality of the model system. We demonstrate that predictions of a detailed geophysical model of the wave evolution are reproduced accurately using a Bayesian approach. In this surf-zone application, forward prediction skill was 83%, and uncertainties in the model inputs were accurately transferred to uncertainty in output variables. We also demonstrate that if modeling uncertainties were not conveyed to the Bayesian network (i.e., perfect data or model were assumed), then overly optimistic prediction uncertainties were computed. More consistent predictions and uncertainties were obtained by including model-parameter errors as a source of input uncertainty. Improved predictions (skill of 90%) were achieved because the Bayesian network simultaneously estimated optimal parameters while predicting wave heights.

  4. Absolute cross sections for the multielectron processes in 15 keV I10++rare gas collisions

    International Nuclear Information System (INIS)

    Nakamura, N.; Currell, F.J.; Danjo, A.; Kimura, M.; Matsumoto, A.; Ohtani, S.; Sakaue, H.A.; Sakurai, M.; Tawara, H.; Watanabe, H.; Yamada, I.; Yoshino, M.

    1995-01-01

    We have experimentally determined the absolute cross sections for total charge transfer (σ q ), j electron transfer (σ j q ), i electron capture (σ q,q-i ) and each reaction process (σ j q,q-i ) in 15 keV I 10+ -Ne, Ar, Kr and Xe collisions. The branching ratios were determined by the coincidence measurements between charge changing projectile and recoil ions. The electron capture cross sections were measured by the initial growth rate method. The experimental results for total and j electron transfer cross sections were compared with the predictions of the extended classical over-barrier model (ECBM). (orig.)

  5. Multicurie, transportable, integrally shielded 123Xe → 123I generator and processing system for high-purity iodine-123 production

    International Nuclear Information System (INIS)

    Lagunas-Solar, M.C.; Thibeau, H.L.; Goodart, C.E.; Little, F.E.; Navarro, N.J.; Hartnett, D.E.

    1985-01-01

    An integrally shielded 123 Xe → 123 I generator system has been designed and tested under production conditions for its suitability as a multicurie handling device from which to produce radiopharmaceutical-quality high-purity no-carrier-added (NCA) 123 I. The 123 Xe → 123 I generator system is expected to provide an alternative to current techniques and to increase the availability and reliability of high-purity 123 I made via the 127 I(p,5n) 123 Xe → 123 I nuclear reaction. The generator system is based on the Crocker Nuclear Laboratory's continuous-flow production system which has been operating since 1974 for the multicurie production of 123 I. The generator system, which consists of an integrally shielded xenon trap and separate loading and processing apparatuses, is simple and reliable to operate, can be adapted to computerized control, and provides a safe working environment for the repeated handling of multicurie amounts of Xe-I radioactivities

  6. Materials, process, product analysis of coal process technology. Phase I final report

    Energy Technology Data Exchange (ETDEWEB)

    Saxton, J. C.; Roig, R. W.; Loridan, A.; Leggett, N. E.; Capell, R. G.; Humpstone, C. C.; Mudry, R. N.; Ayres, E.

    1976-02-01

    The purpose of materials-process-product analysis is a systematic evaluation of alternative manufacturing processes--in this case processes for converting coal into energy and material products that can supplement or replace petroleum-based products. The methodological steps in the analysis include: Definition of functional operations that enter into coal conversion processes, and modeling of alternative, competing methods to accomplish these functions; compilation of all feasible conversion processes that can be assembled from combinations of competing methods for the functional operations; systematic, iterative evaluation of all feasible conversion processes under a variety of economic situations, environmental constraints, and projected technological advances; and aggregative assessments (economic and environmental) of various industrial development scenarios. An integral part of the present project is additional development of the existing computer model to include: A data base for coal-related materials and coal conversion processes; and an algorithmic structure that facilitates the iterative, systematic evaluations in response to exogenously specified variables, such as tax policy, environmental limitations, and changes in process technology and costs. As an analytical tool, the analysis is intended to satisfy the needs of an analyst working at the process selection level, for example, with respect to the allocation of RDandD funds to competing technologies.

  7. Annual Report to Congress

    Science.gov (United States)

    2008-05-01

    Activities DARPA CBW defense program develops revolutionary new detection, diagnostics, decontamination, and medical therapies that are active against...FY 2013 FY 2014 FY 2015 Pr op hy la xe s Botulinum Vaccine June 17, 2004 n Ebola / Marburg Vaccine * 1st Qtr. FY 2012 Multivalent Equine ...effects when used alone (that is, in absence of nerve agent poisoning). Neurologic Therapeutics.• Develop medical countermeasures for protection of

  8. Separation processes, I: Azeotropic rectification

    Directory of Open Access Journals (Sweden)

    Milojević Svetomir

    2005-01-01

    Full Text Available In a series of two articles, the problems of azeotrope separation (part I and the design of separation units (part II were analyzed. The basic definition and equations of vapour-liquid equilibria for ideal and non-ideal systems, the importance of the activity coefficient calculation necessary for the analysis of non-ideal equilibrium systems, as well as theoretical aspects of azeotrope rectification and the determination of the optimal third component (modifier or azeotrope agent are presented in the first part.

  9. Design and simulation of an automation system of a production process and fractionation of 131I, using strategies of advanced control

    International Nuclear Information System (INIS)

    Paez, Jose; Arias, Pablo; Miranda, Jesus

    2013-01-01

    In this report, the results are obtained in the design and simulation of a control system using advanced strategies in a production cell in the Plant Production of Radioisotopes of IPEN. The results demonstrate that the temperature of the coalition oven is stabilized after 30 minutes, being constituted in an advantage to obtain the maximum yield of the cell production of 131 I; also, an integral good controller has been designed that allows to obtain a mathematical model that reproduces with enough accuracy the behavior of the process. With the final simulation it has been to demonstrate that the System Control of Temperature of the Cell Production of 131 I is a controllable system and allows to carry out the respective sequence with other variables of control of the production cell. (author)

  10. iQuantitator: A tool for protein expression inference using iTRAQ

    Directory of Open Access Journals (Sweden)

    Comte-Walters Susana

    2009-10-01

    Full Text Available Abstract Background Isobaric Tags for Relative and Absolute Quantitation (iTRAQ™ [Applied Biosystems] have seen increased application in differential protein expression analysis. To facilitate the growing need to analyze iTRAQ data, especially for cases involving multiple iTRAQ experiments, we have developed a modeling approach, statistical methods, and tools for estimating the relative changes in protein expression under various treatments and experimental conditions. Results This modeling approach provides a unified analysis of data from multiple iTRAQ experiments and links the observed quantity (reporter ion peak area to the experiment design and the calculated quantity of interest (treatment-dependent protein and peptide fold change through an additive model under log transformation. Others have demonstrated, through a case study, this modeling approach and noted the computational challenges of parameter inference in the unbalanced data set typical of multiple iTRAQ experiments. Here we present the development of an inference approach, based on hierarchical regression with batching of regression coefficients and Markov Chain Monte Carlo (MCMC methods that overcomes some of these challenges. In addition to our discussion of the underlying method, we also present our implementation of the software, simulation results, experimental results, and sample output from the resulting analysis report. Conclusion iQuantitator's process-based modeling approach overcomes limitations in current methods and allows for application in a variety of experimental designs. Additionally, hypertext-linked documents produced by the tool aid in the interpretation and exploration of results.

  11. The OrbitOutlook Data Archive

    Science.gov (United States)

    Czajkowski, M.; Shilliday, A.; LoFaso, N.; Dipon, A.; Van Brackle, D.

    2016-09-01

    In this paper, we describe and depict the Defense Advanced Research Projects Agency (DARPA)'s OrbitOutlook Data Archive (OODA) architecture. OODA is the infrastructure that DARPA's OrbitOutlook program has developed to integrate diverse data from various academic, commercial, government, and amateur space situational awareness (SSA) telescopes. At the heart of the OODA system is its world model - a distributed data store built to quickly query big data quantities of information spread out across multiple processing nodes and data centers. The world model applies a multi-index approach where each index is a distinct view on the data. This allows for analysts and analytics (algorithms) to access information through queries with a variety of terms that may be of interest to them. Our indices include: a structured global-graph view of knowledge, a keyword search of data content, an object-characteristic range search, and a geospatial-temporal orientation of spatially located data. In addition, the world model applies a federated approach by connecting to existing databases and integrating them into one single interface as a "one-stop shopping place" to access SSA information. In addition to the world model, OODA provides a processing platform for various analysts to explore and analytics to execute upon this data. Analytic algorithms can use OODA to take raw data and build information from it. They can store these products back into the world model, allowing analysts to gain situational awareness with this information. Analysts in turn would help decision makers use this knowledge to address a wide range of SSA problems. OODA is designed to make it easy for software developers who build graphical user interfaces (GUIs) and algorithms to quickly get started with working with this data. This is done through a multi-language software development kit that includes multiple application program interfaces (APIs) and a data model with SSA concepts and terms such as: space

  12. Supplier Selection within the Process of Analytical Hierarchy in a Business Bir Üretim İşletmesinde Analitik Hiyerarşi Süreci İle Tedarikçi Seçimi

    Directory of Open Access Journals (Sweden)

    Kezban KAPAR

    2013-09-01

    Full Text Available Supplier selection is one of the most critical activities in today's competitive businessworld. Selecting the supplier is a very difficult task to carry out. For determining the bestsupplier selection while assessing all the cases to choose the best approach, the AnalyticalHierarchy Process (AHP is used.AHP is a method used for systematic comparison, evaluation and selection of theoptions via determining the strengths and weaknesses of options. In this study, AHP methodwas utilized in the supplier selection and Expert Choice 11.5 was used while utilizing AHPmethod. The suppliers' superiorities were determined by Expert Choice and they werecompared systematically.Tedarikçi seçimi, günümüz rekabetçi iş dünyasında en kritik faaliyetlerden biridir. Birtedarikçi seçiminde en iyi olanı seçmek zor bir iştir. En iyi tedarikçi seçiminin belirlenmesiiçin çok amaçlı karar verme tekniklerinden birisi olan ve alternatif tedarikçilerdeğerlendirilerek bütün durumlar içinden en iyi olanı seçebilen Analitik Hiyerarşi Süreci(AHS, tedarikçi seçiminde yaygın olarak kullanılan bir yöntemdir.AHS, seçim aşamasında seçeneklerin üstünlüklerinin belirlenmesi ve sistematik olarakkarşılaştırılıp değerlendirilmesini sağlayan bir yöntemdir. Bu çalışmada, bir işletmenintedarikçi seçiminde AHS yönteminden yararlanılmış ve AHS yönteminin kullanılmasındaExpert Choice 11.5 programı kullanılmıştır. Expert Choice ile tedarikçilerin üstünlükleribelirlenmiştir ve sistematik olarak karşılaştırılmıştır.

  13. Recollection is a continuous process: implications for dual-process theories of recognition memory.

    Science.gov (United States)

    Mickes, Laura; Wais, Peter E; Wixted, John T

    2009-04-01

    Dual-process theory, which holds that recognition decisions can be based on recollection or familiarity, has long seemed incompatible with signal detection theory, which holds that recognition decisions are based on a singular, continuous memory-strength variable. Formal dual-process models typically regard familiarity as a continuous process (i.e., familiarity comes in degrees), but they construe recollection as a categorical process (i.e., recollection either occurs or does not occur). A continuous process is characterized by a graded relationship between confidence and accuracy, whereas a categorical process is characterized by a binary relationship such that high confidence is associated with high accuracy but all lower degrees of confidence are associated with chance accuracy. Using a source-memory procedure, we found that the relationship between confidence and source-recollection accuracy was graded. Because recollection, like familiarity, is a continuous process, dual-process theory is more compatible with signal detection theory than previously thought.

  14. How Do I Deal with Depression and Adjustment to My Spinal Cord Injury?

    Medline Plus

    Full Text Available ... are my options? How can I apply for Social Security benefits? How do I find a rehabilitation facility? How can I locate funding for rehabilitation and equipment? What do I need to know about stem cell research? What is the clinical trials process? Get support Ask us anything Get a peer mentor Find ...

  15. From face processing to face recognition: Comparing three different processing levels.

    Science.gov (United States)

    Besson, G; Barragan-Jason, G; Thorpe, S J; Fabre-Thorpe, M; Puma, S; Ceccaldi, M; Barbeau, E J

    2017-01-01

    Verifying that a face is from a target person (e.g. finding someone in the crowd) is a critical ability of the human face processing system. Yet how fast this can be performed is unknown. The 'entry-level shift due to expertise' hypothesis suggests that - since humans are face experts - processing faces should be as fast - or even faster - at the individual than at superordinate levels. In contrast, the 'superordinate advantage' hypothesis suggests that faces are processed from coarse to fine, so that the opposite pattern should be observed. To clarify this debate, three different face processing levels were compared: (1) a superordinate face categorization level (i.e. detecting human faces among animal faces), (2) a face familiarity level (i.e. recognizing famous faces among unfamiliar ones) and (3) verifying that a face is from a target person, our condition of interest. The minimal speed at which faces can be categorized (∼260ms) or recognized as familiar (∼360ms) has largely been documented in previous studies, and thus provides boundaries to compare our condition of interest to. Twenty-seven participants were included. The recent Speed and Accuracy Boosting procedure paradigm (SAB) was used since it constrains participants to use their fastest strategy. Stimuli were presented either upright or inverted. Results revealed that verifying that a face is from a target person (minimal RT at ∼260ms) was remarkably fast but longer than the face categorization level (∼240ms) and was more sensitive to face inversion. In contrast, it was much faster than recognizing a face as familiar (∼380ms), a level severely affected by face inversion. Face recognition corresponding to finding a specific person in a crowd thus appears achievable in only a quarter of a second. In favor of the 'superordinate advantage' hypothesis or coarse-to-fine account of the face visual hierarchy, these results suggest a graded engagement of the face processing system across processing

  16. Brand I Feel Slovenia: Inclusion of the Key Areas’ Representatives in the Branding Process

    Directory of Open Access Journals (Sweden)

    Maja Konecnik Ruzzier

    2011-12-01

    Full Text Available The paper presents the part of the process of I feel Slovenia brand developmentin which we investigated 707 respondents from key stakeholdergroups. Respondents were representatives of all key stakeholdergroups in the country who, along with the other two target groups (opinionleaders and local inhabitants, represented the most importantstakeholders in the process of country brand development. A strongagreement regarding brand identity elements is evident from researchresults, which imply that identity elements shared by representativesfrom different internal stakeholder groups should form the basis of astrong country brand. Such brand foundation represents a strong preconditionfor a country brand, which could through hard and systematicwork become a strong and successful brand.

  17. I am active”: effects of a program to promote active aging

    OpenAIRE

    Mendoza-Ruvalcaba NM; Arias-Merino ED

    2015-01-01

    Neyda Ma Mendoza-Ruvalcaba,1 Elva Dolores Arias-Merino2 1Health Sciences Department, University of Guadalajara, University Center of Tonala Guadalajara, Jalisco, Mexico; 2Public Health Department, University of Guadalajara, University Center of Health Sciences, Guadalajara, Jalisco, Mexico Background: Active aging involves a general lifestyle strategy that allows preservation of both physical and mental health during the aging process. “I am Active” is a program designed...

  18. iPhone and iOS Forensics Investigation, Analysis and Mobile Security for Apple iPhone, iPad and iOS Devices

    CERN Document Server

    Hoog, Andrew

    2011-01-01

    As sales and usage of iPhones increase so does the demand on organizations that conduct examinations on this device. iPhone and iOS Forensics takes an in-depth look at methods and processes that analyze the iPhone/iPod in an official legal manner. All of the methods and procedures outlined in the book can be taken into any court room. This book details the iPhone with information data sets that are new and evolving, with official hardware knowledge from Apple itself to help aid investigators.  iPhone market share has increased to 50% of worldwide mobile phone usageEmployment in digital fo

  19. Prespacer processing and specific integration in a Type I-A CRISPR system

    Science.gov (United States)

    Rollie, Clare; Graham, Shirley; Rouillon, Christophe

    2018-01-01

    Abstract The CRISPR–Cas system for prokaryotic adaptive immunity provides RNA-mediated protection from viruses and mobile genetic elements. Adaptation is dependent on the Cas1 and Cas2 proteins along with varying accessory proteins. Here we analyse the process in Sulfolobus solfataricus, showing that while Cas1 and Cas2 catalyze spacer integration in vitro, host factors are required for specificity. Specific integration also requires at least 400 bp of the leader sequence, and is dependent on the presence of hydrolysable ATP, suggestive of an active process that may involve DNA remodelling. Specific spacer integration is associated with processing of prespacer 3′ ends in a PAM-dependent manner. This is reflected in PAM-dependent processing of prespacer 3′ ends in vitro in the presence of cell lysate or the Cas4 nuclease, in a reaction consistent with PAM-directed binding and protection of prespacer DNA. These results highlight the diverse interplay between CRISPR–Cas elements and host proteins across CRISPR types. PMID:29228332

  20. "I'm on a Journey I Never Thought I'd Be On": Using Process Drama Pedagogy for the Literacy Programme

    Science.gov (United States)

    Wells, Trish; Sandretto, Susan

    2017-01-01

    This paper argues that process drama is a productive pedagogy with multiple affordances for multiliteracies. We describe an exploratory study in which two teachers from a rural New Zealand primary school used process drama pedagogy in the literacy programme. Analysis of the initial and exit teacher interviews, lesson transcripts and transcripts of…

  1. There's always a villain to punish: group processes contributing to violence and its remediation.

    Science.gov (United States)

    Thomas, Nina K

    2015-01-01

    This paper considers the widespread use of violent metaphors, such as "combat" and "war," to represent the current social, psychological, and political problems within the United States. I apply Lakoff and Johnson's (1980) thesis that metaphor shapes thought, policy, and behavior. I examine how use of such metaphors inclines the national consciousness toward violence and punishment for it. In addition, I discuss shame and humiliation as psychological precursors of violence, particularly as these play out in the exclusion and extrusion via group scapegoating of individuals and whole groups from active participation in an esteemed or powerful other group. Included within the concept of "violence" are those harmful social policies that invalidate the experiences of disempowered people within the United States. I consider the role of group processes in resolving the injuries wrought by violence, particularly as these operate within such restorative justice projects as the Glencree Ex-Combatants Programme in Northern Ireland. Lessons emerge from restorative justice projects installed internationally for ameliorating conflict within and between "victim" groups in the United States.

  2. Gradient Index Optics at DARPA

    Science.gov (United States)

    2013-11-01

    for correcting vision. René Descartes proposed another idea to cor- rect vision in 1636: use a glass tube filled with liquid and place it in direct... Descartes published the present form of this law, a basis of modern geometric optics known as Snell’s Law (Fishman 2000, 405, 408) (see Figure 1-6). At

  3. Los Alamos Controlled Air Incinerator for radioactive waste. Volume I. Rationale, process, equipment, performance, and recommendations

    International Nuclear Information System (INIS)

    Neuls, A.S.; Draper, W.E.; Koenig, R.A.; Newmyer, J.M.; Warner, C.L.

    1982-08-01

    This two-volume report is a detailed design and operating documentation of the Los Alamos National Laboratory Controlled Air Incinerator (CAI) and is an aid to technology transfer to other Department of Energy contractor sites and the commercial sector. Volume I describes the CAI process, equipment, and performance, and it recommends modifications based on Los Alamos experience. It provides the necessary information for conceptual design and feasibility studies. Volume II provides descriptive engineering information such as drawing, specifications, calculations, and costs. It aids duplication of the process at other facilities

  4. Los Alamos Controlled Air Incinerator for radioactive waste. Volume I. Rationale, process, equipment, performance, and recommendations

    Energy Technology Data Exchange (ETDEWEB)

    Neuls, A.S.; Draper, W.E.; Koenig, R.A.; Newmyer, J.M.; Warner, C.L.

    1982-08-01

    This two-volume report is a detailed design and operating documentation of the Los Alamos National Laboratory Controlled Air Incinerator (CAI) and is an aid to technology transfer to other Department of Energy contractor sites and the commercial sector. Volume I describes the CAI process, equipment, and performance, and it recommends modifications based on Los Alamos experience. It provides the necessary information for conceptual design and feasibility studies. Volume II provides descriptive engineering information such as drawing, specifications, calculations, and costs. It aids duplication of the process at other facilities.

  5. How To Naturalize Sensory Consciousness and Intentionality Within A Process Monism With Normativity Gradient

    DEFF Research Database (Denmark)

    Seibt, Johanna

    2016-01-01

    of many forms of process architectures that realize non-linear causation. Nowadays, with the benefit of scientific hindsight in embodied cognition and dynamic systems theory, it should be easier to recognize that Sellars’ philosophy has the Gestalt of a process monism with levels of increasingly more...... this commitment and attributes to Sellars a metaphysical bifurcation into a ‘causal order’ and the ‘space of reasons’. Against this I show that Sellars can be read as championing a process monism with different types of processing at different levels of complexity, where linear mechanistic causation is only one...... complex forms of processing that work up significances in ever wider regulatory contexts, with physiological signals at one extreme and normative content at the other. Within human organisms processing at the level of mechanistic causation is embedded in a series of more emcompassing process architectures...

  6. Parkin Mutations Reduce the Complexity of Neuronal Processes in iPSC-derived Human Neurons

    Science.gov (United States)

    Ren, Yong; Jiang, Houbo; Hu, Zhixing; Fan, Kevin; Wang, Jun; Janoschka, Stephen; Wang, Xiaomin; Ge, Shaoyu; Feng, Jian

    2015-01-01

    Parkinson’s disease (PD) is characterized by the degeneration of nigral dopaminergic (DA) neurons and non-DA neurons in many parts of the brain. Mutations of parkin, an E3 ubiquitin ligase that strongly binds to microtubules, are the most frequent cause of recessively inherited Parkinson’s disease. The lack of robust PD phenotype in parkin knockout mice suggests a unique vulnerability of human neurons to parkin mutations. Here, we show that the complexity of neuronal processes as measured by total neurite length, number of terminals, number of branch points and Sholl analysis, was greatly reduced in induced pluripotent stem cell (iPSC)-derived TH+ or TH− neurons from PD patients with parkin mutations. Consistent with these, microtubule stability was significantly decreased by parkin mutations in iPSC-derived neurons. Overexpression of parkin, but not its PD-linked mutant nor GFP, restored the complexity of neuronal processes and the stability of microtubules. Consistent with these, the microtubule-depolymerizing agent colchicine mimicked the effect of parkin mutations by decreasing neurite length and complexity in control neurons while the microtubule-stabilizing drug taxol mimicked the effect of parkin overexpression by enhancing the morphology of parkin-deficient neurons. The results suggest that parkin maintains the morphological complexity of human neurons by stabilizing microtubules. PMID:25332110

  7. Introduction to radiation processing

    International Nuclear Information System (INIS)

    Kume, Tamikazu

    2008-01-01

    Nuclear technology such as γ-rays, electron beams and ion beams irradiation is widely used in industrial, medical and agricultural fields. The purpose of radiation application is aiming at increasing welfare and quality of our life. Radiation technology applied to medical care is widely known as X-ray diagnosis but the contribution of radiation processing to our daily life is not well known even though it is effectively used in industry and agriculture. The main radiation processing in industry is the modification of polymers, i.e. heat shrinkable tube, radial tire, plastic foam, etc. in a car, heat resistant wire and cable, semiconductor, floppy disk, etc. in a computer, and sterilization of medical devices. In Agriculture, radiation has been used in various fields such as food irradiation, sterile insect technique, mutation breeding, etc. contributing for human being to supply foods and sustainable environment. (author)

  8. A Conceptual Discussion of the Strategy Process in Organizations: Formulation and Formation of StrategyHttp://Dx.Doi.Org/10.5585/Riae.V10i1.1711

    Directory of Open Access Journals (Sweden)

    Mônica Külkamp Beppler

    2011-06-01

    Full Text Available This article aims to address the strategy process within organizations, in light of the terminologies of strategic formulation and formation. The purpose is to elucidate the understanding of persistently used terms, occasionally causing a lack of interpretation of what is actually exposed about the strategy process, i.e., the variations between adopting i classic strategies, which call for different stages of formulation and implementation, and ii emerging strategies, or those having a procedural nature, performed in response to environmental changes. The present article also targets clarifying the characteristics of each approach through the theoretical construct of authors. This research is characterized as a descriptive study, predominantly qualitative and where the collected data were obtained through a literature review. Through analysis of the most prominent authors on strategy, it was found that the differences between strategic formulation and formation are not limited to the used terminology. Said approaches have significant differences within the entire strategy process, differing mainly in how they occur within organizations: in strategic formulation, there is a prescriptive, deliberate and rational process, whereas in strategic formation, emphasis on description exists, and the strategy is an emergent, unintentional process, consolidated by a series of patterns of decisions over time. Finally, perceiving the distinction between the two approaches is considered fundamental for the understanding of strategy in organizations, especially in regard to variables potentially influencing its process.

  9. Two additions to the <i>Jacea-Lepteranthus> complex: parallel adaptation in the enigmatic species <i>Centaurea subtilisi> and <i>C. exaratai>

    Directory of Open Access Journals (Sweden)

    Hilpold, A.

    2009-12-01

    Full Text Available <i>Centaurea subtilisi> from south east Italy and <i>C. exaratai> from south west Iberia were classified in the <i>Acrolophus- Phalolepisi> group and therein in section <i>Maculosae>. A molecular survey based on ITS sequence data indicates that both species should rather be placed in the <i>Jacea-Lepteranthus> group instead. This placement is consistent with the chromosome number of the two species, which is x = 11 like the rest of species of the <i>Jacea-Lepteranthus> group, and differs from the x = 9 of the other taxa included in sect. Maculosae. These results confi rm previous suggestions on the unnaturality of sect. <i>Maculosae. Centaurea exaratai> and <i>C. subtilisi> are quite different from the other species of <i>Jacea-Lepteranthus> in some striking morphological characters, which we hypothesize to be the result of parallel adaptation to dryer climates. The lack of competitors for pollination might be a good explanation for the partial or even total loss of showy flowers in these two species.

    [es] <i>Centaurea subtilisi
    > del sureste de Italia y <i>C. exaratai
    > del suroeste de la Península Ibérica fueron clasificadas anteriormente en el grupo <i>Acrolophus-Phalolepis> y dentro de él en la sect. <i>Maculosae>. Una revisión molecular basada en secuencias de la región ITS indica que ambas deberían clasificarse en el grupo <i>Jacea-Lepteranthus>. Este cambio es coherente con el número cromosómico de las dos especies, que tienen x = 11 como el resto de las especies del grupo <i>Jacea-Lepteranthus> y no x = 9 como las especies del grupo <i>Acrolophus-Phalolepis>. Estos resultados confirman advertencias anteriores sobre el carácter artificial de la sect. <i>Maculosae. Centaurea exaratai> y <i>C. subtilisi> son bastante diferentes de las otras especies de <i>Jacea-Lepteranthus> en algunos caracteres morfológicos importantes, resultado, según nuestra hipótesis, de adaptaciones a

  10. Extraterrestrial Metals Processing, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — The Extraterrestrial Metals Processing (EMP) system produces ferrosilicon, silicon monoxide, a glassy mixed oxide slag, and smaller amounts of alkali earth...

  11. Colosed-Loop Control of the Thermal Stir Welding Process to Enable Rapid Process/Ppart Qualification, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Thermal Stir Welding (TSW) provides advancement over the more conventional Friction Stir Welding (C-FSW) process because it separates the primary processes variables...

  12. Eye Tracking Meets the Process of Process Modeling: a Visual Analytic Approach

    DEFF Research Database (Denmark)

    Burattin, Andrea; Kaiser, M.; Neurauter, Manuel

    2017-01-01

    Research on the process of process modeling (PPM) studies how process models are created. It typically uses the logs of the interactions with the modeling tool to assess the modeler’s behavior. In this paper we suggest to introduce an additional stream of data (i.e., eye tracking) to improve the ...

  13. A Real-Time Java Virtual Machine for Avionics (Preprint)

    National Research Council Canada - National Science Library

    Armbruster, Austin; Pla, Edward; Baker, Jason; Cunei, Antonio; Flack, Chapman; Pizlo, Filip; Vitek, Jan; Proch zka, Marek; Holmes, David

    2006-01-01

    ...) in the DARPA Program Composition for Embedded System (PCES) program. Within the scope of PCES, Purdue University and the Boeing Company collaborated on the development of Ovm, an open source implementation of the RTSJ virtual machine...

  14. Measuring and Reconstructing the Brain at the Synaptic Scale: Towards a Biofidelic Human Brain in silico

    OpenAIRE

    NeuroData; CE, Priebe; Burns, R.; RJ, Vogelstein

    2015-01-01

    Vogelstein JT, Priebe CE, Burns R, Vogelstein RJ, Lichtman J. Measuring and Reconstructing the Brain at the Synaptic Scale: Towards a Biofidelic Human Brain in silico. DARPA Neural Engineering, Science and Technology Forum, 2010

  15. Program Visualization

    Science.gov (United States)

    1983-02-22

    Scientific Computing Symposiumn an Han-Machine C om unication (1965) 57-71. 1353 Sutherland , l.3., SUICUPADs a man-machine graphical comunica- tie. systems...Institute and was held at the university’s Idylwild Campus. July 1982 Craig Fields and Clint Kelly of DARPA visited CCA on July 6. Christopher Herot and...on December 9. We gave him an extended PV slide presentation and a demonstration of the system. Clint Kelly of DARPA visited on January 13, and he

  16. TOEFL strategies a complete guide to the iBT

    CERN Document Server

    Stirling, Bruce

    2016-01-01

    TOEFL students all ask: How can I get a high TOEFL iBT score? Answer: Learn argument scoring strategies. Why? Because the TOEFL iBT recycles opinion-based and fact-based arguments for testing purposes from start to finish. In other words, the TOEFL iBT is all arguments. That's right, all arguments. If you want a high score, you need essential argument scoring strategies. That is what TOEFL STRATEGIES A COMPLETE GUIDE gives you, and more!

  17. A HUMAN FACTORS ENGINEERING PROCESS TO SUPPORT HUMAN-SYSTEM INTERFACE DESIGN IN CONTROL ROOM MODERNIZATION

    Energy Technology Data Exchange (ETDEWEB)

    Kovesdi, C.; Joe, J.; Boring, R.

    2017-05-01

    The primary objective of the United States (U.S.) Department of Energy (DOE) Light Water Reactor Sustainability (LWRS) program is to sustain operation of the existing commercial nuclear power plants (NPPs) through a multi-pathway approach in conducting research and development (R&D). The Advanced Instrumentation, Information, and Control (II&C) System Technologies pathway conducts targeted R&D to address aging and reliability concerns with legacy instrumentation and control (I&C) and other information systems in existing U.S. NPPs. Control room modernization is an important part following this pathway, and human factors experts at Idaho National Laboratory (INL) have been involved in conducting R&D to support migration of new digital main control room (MCR) technologies from legacy analog and legacy digital I&C. This paper describes a human factors engineering (HFE) process that supports human-system interface (HSI) design in MCR modernization activities, particularly with migration of old digital to new digital I&C. The process described in this work is an expansion from the LWRS Report INL/EXT-16-38576, and is a requirements-driven approach that aligns with NUREG-0711 requirements. The work described builds upon the existing literature by adding more detail around key tasks and decisions to make when transitioning from HSI Design into Verification and Validation (V&V). The overall objective of this process is to inform HSI design and elicit specific, measurable, and achievable human factors criteria for new digital technologies. Upon following this process, utilities should have greater confidence with transitioning from HSI design into V&V.

  18. Think-aloud process superior to thought-listing in increasing children's critical processing of advertising

    NARCIS (Netherlands)

    Rozendaal, E.; Buijzen, M.A.; Valkenburg, P.M.

    2012-01-01

    This study develops and tests a model of children's critical processing of advertising. Within this model, 2 paths to reduced advertising susceptibility (i.e., attitude toward the advertised brand) were hypothesized: a cognitive path and an affective path. The secondary aim was to compare these

  19. USAF Logistics Process Optimization Study for the Aircraft Asset Sustainment Process. Volume 3. Future to be Asset Sustainment Process Model

    National Research Council Canada - National Science Library

    Adamson, Anthony

    1998-01-01

    .... It is published as three separate volumes. Volume I, USAF Logistics Process Optimization Study for the Aircraft Asset Sustainment Process -- Phase II Report, discusses the result and cost/benefit analysis of testing three initiatives...

  20. DARPA Status Report - November 1988

    Science.gov (United States)

    1988-11-01

    equilibrium the absolute coe function no longer changes, this mom fine optimiaion. This allows a tradeoff berka implies thax the expected value of the...the trace, simply that the author of PERO bad made an explicit deci- where vs is the numbe of processors. In other words, the Limes sion not to use...The positive portion of P (AC) must either shift right (greater bad moves) or up (more bad moves), k- - "𔃼asing the expected positive component of AC

  1. Konceptuel model for forureningsfordeling og processer for chlorerede opløsningsmidler i moræneler. Har vi et samlet overblik?

    DEFF Research Database (Denmark)

    Broholm, Mette Martina; Damgaard, Ida; Cong, Lu

    2012-01-01

    Der er i REMTEC projektet opnået en betydelig større viden om betydende processer for transport og specielt for nedbrydning af chlorerede ethener og ethaner i moræneler. Sorption i moræneler er relativt høj. Specifikke nedbrydere kan spredes i matrix i moræneler, hvilket muliggør større og mere d...

  2. The Integration of DCS I/O to an Existing PLC

    Science.gov (United States)

    Sadhukhan, Debashis; Mihevic, John

    2013-01-01

    At the NASA Glenn Research Center (GRC), Existing Programmable Logic Controller (PLC) I/O was replaced with Distributed Control System (DCS) I/O, while keeping the existing PLC sequence Logic. The reason for integration of the PLC logic and DCS I/O, along with the evaluation of the resulting system is the subject of this paper. The pros and cons of the old system and new upgrade are described, including operator workstation screen update times. Detail of the physical layout and the communication between the PLC, the DCS I/O and the operator workstations are illustrated. The complex characteristics of a central process control system and the plan to remove the PLC processors in future upgrades is also discussed.

  3. The iSchool Community

    DEFF Research Database (Denmark)

    Bogers, Toine; Greifeneder, Elke

    2016-01-01

    the reviewer pool more representative of the iSchool community as a whole by including more women and more researchers from Asian institutions. Other recommendations are to improve the continuity of the reviewer pool and to provide clearer instructions to reviewers to ensure that written reviews explicitly...... cover all the aspects represented by the review scores. The results of our study provide the iSchool community with a descriptive analysis of its community and a better understanding of its review process.......A fair review process is essential to the success of any scientific conference. In this paper we present an analysis of the reviewing process of the 2014-2015 iConferences as well as a demographic analysis of the iConference community as a whole. The results show a clear need for making...

  4. How to implement a theory of correctness in the area of business processes and services

    NARCIS (Netherlands)

    Lohmann, N.; Wolf, K.; Hull, R.; Mendling, J.; Tai, S.

    2010-01-01

    During the previous years, we presented several results concerned with various issues related to the correctness of models for business processes and services (i. e., interorganizational business processes). For most of the results, we presented tools and experimental evidence for the computational

  5. Working through. A process of restitution.

    Science.gov (United States)

    Gottesman, D M

    A number of authors, including Freud, have written about the process of working through but have left unsettled what is actually involved. I have attempted to outline the step-by-step process of working through, starting with recollection and repetition and ending with restitution and resolution. I have introduced the term restitution in order to give more importance to an already existing step in the working-throught process; it should not be looked upon as an artificial device. Restitution allows the patient to find appropriate gratification in present reality, and this helps him to relinquish the past. Rather than allowing the patient to "wallow in the muck of guilt," as Eveoleen Rexford suggests society "wallows" in its inability to help its children, restitution gives appropriate direction for change. It is a natural step in the successful resolution of treatment.

  6. iAssist: a software framework for intelligent patient monitoring.

    Science.gov (United States)

    Brouse, Christopher; Dumont, Guy; Yang, Ping; Lim, Joanne; Ansermino, J Mark

    2007-01-01

    A software framework (iAssist) has been developed for intelligent patient monitoring, and forms the foundation of a clinical monitoring expert system. The framework is extensible, flexible, and interoperable. It supports plugins to perform data acquisition, signal processing, graphical display, data storage, and output to external devices. iAssist currently incorporates two plugins to detect change point events in physiological trends. In 38 surgical cases, iAssist detected 868 events, of which clinicians rated more than 50% as clinically significant and less than 7% as artifacts. Clinicians found iAssist intuitive and easy to use.

  7. "I am active": effects of a program to promote active aging.

    Science.gov (United States)

    Mendoza-Ruvalcaba, Neyda Ma; Arias-Merino, Elva Dolores

    2015-01-01

    Active aging involves a general lifestyle strategy that allows preservation of both physical and mental health during the aging process. "I am Active" is a program designed to promote active aging by increased physical activity, healthy nutritional habits, and cognitive functioning. The purpose of this study was to assess the effectiveness of this program. Sixty-four healthy adults aged 60 years or older were recruited from senior centers and randomly allocated to an experimental group (n=31) or a control group (n=33). Baseline, post-test, and 6-month follow-up assessments were performed after the theoretical-practical intervention. Effect sizes were calculated. At the conclusion of the program, the experimental group showed significant improvement compared with the control group in the following domains: physical activity (falls risk, balance, flexibility, self-efficacy), nutrition (self-efficacy and nutritional status), cognitive performance (processing speed and self-efficacy), and quality of life (general, health and functionality, social and economic status). Although some declines were reported, improvements at follow-up remained in self-efficacy for physical activity, self-efficacy for nutrition, and processing speed, and participants had better nutritional status and quality of life overall. Our findings show that this program promotes improvements in domains of active aging, mainly in self-efficacy beliefs as well as in quality of life in healthy elders.

  8. Markov Jump Processes Approximating a Non-Symmetric Generalized Diffusion

    International Nuclear Information System (INIS)

    Limić, Nedžad

    2011-01-01

    Consider a non-symmetric generalized diffusion X(⋅) in ℝ d determined by the differential operator A(x) = -Σ ij ∂ i a ij (x)∂ j + Σ i b i (x)∂ i . In this paper the diffusion process is approximated by Markov jump processes X n (⋅), in homogeneous and isotropic grids G n ⊂ℝ d , which converge in distribution in the Skorokhod space D([0,∞),ℝ d ) to the diffusion X(⋅). The generators of X n (⋅) are constructed explicitly. Due to the homogeneity and isotropy of grids, the proposed method for d≥3 can be applied to processes for which the diffusion tensor {a ij (x)} 11 dd fulfills an additional condition. The proposed construction offers a simple method for simulation of sample paths of non-symmetric generalized diffusion. Simulations are carried out in terms of jump processes X n (⋅). For piece-wise constant functions a ij on ℝ d and piece-wise continuous functions a ij on ℝ 2 the construction and principal algorithm are described enabling an easy implementation into a computer code.

  9. Implementing iRound: A Computer-Based Auditing Tool.

    Science.gov (United States)

    Brady, Darcie

    Many hospitals use rounding or auditing as a tool to help identify gaps and needs in quality and process performance. Some hospitals are also using rounding to help improve patient experience. It is known that purposeful rounding helps improve Hospital Consumer Assessment of Healthcare Providers and Systems scores by helping manage patient expectations, provide service recovery, and recognize quality caregivers. Rounding works when a standard method is used across the facility, where data are comparable and trustworthy. This facility had a pen-and-paper process in place that made data reporting difficult, created a silo culture between departments, and most audits and rounds were completed differently on each unit. It was recognized that this facility needed to standardize the rounding and auditing process. The tool created by the Advisory Board called iRound was chosen as the tool this facility would use for patient experience rounds as well as process and quality rounding. The success of the iRound tool in this facility depended on several factors that started many months before implementation to current everyday usage.

  10. Knowledge-based inspection:modelling complex processes with the integrated Safeguards Modelling Method (iSMM)

    International Nuclear Information System (INIS)

    Abazi, F.

    2011-01-01

    Increased level of complexity in almost every discipline and operation today raises the demand for knowledge in order to successfully run an organization whether to generate profit or to attain a non-profit mission. Traditional way of transferring knowledge to information systems rich in data structures and complex algorithms continue to hinder the ability to swiftly turnover concepts into operations. Diagrammatic modelling commonly applied in engineering in order to represent concepts or reality remains to be an excellent way of converging knowledge from domain experts. The nuclear verification domain represents ever more a matter which has great importance to the World safety and security. Demand for knowledge about nuclear processes and verification activities used to offset potential misuse of nuclear technology will intensify with the growth of the subject technology. This Doctoral thesis contributes with a model-based approach for representing complex process such as nuclear inspections. The work presented contributes to other domains characterized with knowledge intensive and complex processes. Based on characteristics of a complex process a conceptual framework was established as the theoretical basis for creating a number of modelling languages to represent the domain. The integrated Safeguards Modelling Method (iSMM) is formalized through an integrated meta-model. The diagrammatic modelling languages represent the verification domain and relevant nuclear verification aspects. Such a meta-model conceptualizes the relation between practices of process management, knowledge management and domain specific verification principles. This fusion is considered as necessary in order to create quality processes. The study also extends the formalization achieved through a meta-model by contributing with a formalization language based on Pattern Theory. Through the use of graphical and mathematical constructs of the theory, process structures are formalized enhancing

  11. Enterprise iPhone and iPad Administrator's Guide Strategies for iPhone Deployment, Integration, and Control

    CERN Document Server

    Edge, Charles

    2010-01-01

    Are you an IT professional involved in deploying the iPhone and or iPad in your company or organization? Do you have fellow employees who are eager to use their iPhones and iPads for work? Then this is the book for you. Enterprise iPhone and iPad Administrator's Guide provides step-by-step instructions on how to deploy and integrate the iPhone within a range of professional environments - from large businesses and educational institutions to medium-sized offices. This book ensures that the process is achieved in a streamlined, efficient, and cost-effective manner. The guide begins with an intr

  12. DOE underground storage tank waste remediation chemical processing hazards. Part I: Technology dictionary

    International Nuclear Information System (INIS)

    DeMuth, S.F.

    1996-10-01

    This document has been prepared to aid in the development of Regulating guidelines for the Privatization of Hanford underground storage tank waste remediation. The document has been prepared it two parts to facilitate their preparation. Part II is the primary focus of this effort in that it describes the technical basis for established and potential chemical processing hazards associated with Underground Storage Tank (UST) nuclear waste remediation across the DOE complex. The established hazards involve those at Sites for which Safety Analysis Reviews (SARs) have already been prepared. Potential hazards are those involving technologies currently being developed for future applications. Part I of this document outlines the scope of Part II by briefly describing the established and potential technologies. In addition to providing the scope, Part I can be used as a technical introduction and bibliography for Regulatory personnel new to the UST waste remediation, and in particular Privatization effort. Part II of this document is not intended to provide examples of a SAR Hazards Analysis, but rather provide an intelligence gathering source for Regulatory personnel who must eventually evaluate the Privatization SAR Hazards Analysis

  13. Screening tool for oropharyngeal dysphagia in stroke - Part I: evidence of validity based on the content and response processes.

    Science.gov (United States)

    Almeida, Tatiana Magalhães de; Cola, Paula Cristina; Pernambuco, Leandro de Araújo; Magalhães, Hipólito Virgílio; Magnoni, Carlos Daniel; Silva, Roberta Gonçalves da

    2017-08-17

    The aim of the present study was to identify the evidence of validity based on the content and response process of the Rastreamento de Disfagia Orofaríngea no Acidente Vascular Encefálico (RADAVE; "Screening Tool for Oropharyngeal Dysphagia in Stroke"). The criteria used to elaborate the questions were based on a literature review. A group of judges consisting of 19 different health professionals evaluated the relevance and representativeness of the questions, and the results were analyzed using the Content Validity Index. In order to evidence validity based on the response processes, 23 health professionals administered the screening tool and analyzed the questions using a structured scale and cognitive interview. The RADAVE structured to be applied in two stages. The first version consisted of 18 questions in stage I and 11 questions in stage II. Eight questions in stage I and four in stage II did not reach the minimum Content Validity Index, requiring reformulation by the authors. The cognitive interview demonstrated some misconceptions. New adjustments were made and the final version was produced with 12 questions in stage I and six questions in stage II. It was possible to develop a screening tool for dysphagia in stroke with adequate evidence of validity based on content and response processes. Both validity evidences obtained so far allowed to adjust the screening tool in relation to its construct. The next studies will analyze the other evidences of validity and the measures of accuracy.

  14. Polysynovitis in a horse due to [i]Borrelia burgdorferi[/i] sensu lato infection – Case study

    Directory of Open Access Journals (Sweden)

    Fabrizio Passamonti

    2015-05-01

    Full Text Available Lyme borreliosis (LB is a multi-systemic tick-borne disease affecting both humans and animals, including horses, and is caused by a group of interrelated spirochetes classified within the[i] Borrelia burgdorferi [/i]sensu lato (s.l. complex. Despite the high reported seroprevalence in the European equine population for [i]B. burgdorferi[/i] s.l., to-date no documented clinical cases have been described. A 6-year-old Paint gelding was referred with a history of three weeks of fever, intermittent lameness and digital flexor tendon sheath effusion of the right hind limb. Based on a strict diagnostic protocol, which included serological tests for infectious diseases and molecular investigations, a final diagnosis was made of polysynovitis due to [i]B. burgdorferi [/i]s.l. infection. An unreported aspect observed in this case was the absence of the pathogen DNA in two of the affected joints. To the authors’ knowledge, the case described represents the first documented clinical case of equine LB in Italy. Moreover, the absence of pathogen DNA in two of the affected joints observed in this case revealed a possible similarity with the same condition described in humans, where an immunomediated pathogenesis for arthropathy due to [i]B. burgdorferi[/i] s.l. infection is suspected. Since humans and horses share the same habitat, this report supports the role of the horse as potential sentinel for human biological risk.

  15. Peripheral blood aspirates overexpressing IGF-I via rAAV gene transfer undergo enhanced chondrogenic differentiation processes.

    Science.gov (United States)

    Frisch, Janina; Orth, Patrick; Rey-Rico, Ana; Venkatesan, Jagadeesh Kumar; Schmitt, Gertrud; Madry, Henning; Kohn, Dieter; Cucchiarini, Magali

    2017-11-01

    Implantation of peripheral blood aspirates induced towards chondrogenic differentiation upon genetic modification in sites of articular cartilage injury may represent a powerful strategy to enhance cartilage repair. Such a single-step approach may be less invasive than procedures based on the use of isolated or concentrated MSCs, simplifying translational protocols in patients. In this study, we provide evidence showing the feasibility of overexpressing the mitogenic and pro-anabolic insulin-like growth factor I (IGF-I) in human peripheral blood aspirates via rAAV-mediated gene transfer, leading to enhanced proliferative and chondrogenic differentiation (proteoglycans, type-II collagen, SOX9) activities in the samples relative to control (reporter rAAV-lacZ) treatment over extended periods of time (at least 21 days, the longest time-point evaluated). Interestingly, IGF-I gene transfer also triggered hypertrophic, osteo- and adipogenic differentiation processes in the aspirates, suggesting that careful regulation of IGF-I expression may be necessary to contain these events in vivo. Still, the current results demonstrate the potential of targeting human peripheral blood aspirates via therapeutic rAAV transduction as a novel, convenient tool to treat articular cartilage injuries. © 2017 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

  16. Designing a Mobile Application: The Case of iAdvocate

    Directory of Open Access Journals (Sweden)

    Alan R. Foley

    2012-01-01

    Full Text Available In this article, the design of a mobile application (app called iAdvocate is illustrated. The goal of iAdvocate is to share and develop specific strategies with parents of children with disabilities for working collaboratively with a school team to improve their children’s education. iAdvocate uses problem-based learning strategies, simulations, and provides contextual access resources to build parental advocacy skills and knowledge. iAdvocate provides parents with both information and strategies regarding their educational rights and getting their child’s needs met. The goal of iAdvocate is to share and develop specific strategies with parents for working collaboratively with a school team to improve their children’s education. iAdvocate contains three sections: strategies, a compilation of approaches that parents can pursue as advocates; resources, which lists and, where possible, links to such references as laws, books, articles, web sites, video presentations, and organizations that provide information on inclusive education; and, responses, which features simulated interactions, such as replies to common statements made by school professionals regarding services and accommodations for children. This case illustrates the design processes and techniques used to develop an instructional mobile application by presenting the background and context of the project, initial design and design iterations, negative case analysis, and prototyping. Additional documents illustrating the project background, and design process are also included.

  17. Radiation damage of CsI(Tl) scintillators: blocking of energy transfer process of V sub k centers to Tl sup + activators

    CERN Document Server

    Hamada, M M; Shimizu, S; Kubota, S

    2002-01-01

    This paper reports the emission spectra, light output, transmission and decay curves of CsI(Tl) crystals irradiated with gamma rays at different doses, ranging from 1x10 sup 5 to 5x10 sup 5 Gy. The crystals were coated with black or white tapes. Significant decreases in the emission spectra and light output values were observed for the crystals coated with white tape as the radiation dose increased. The decrease in the degree of the rising part of the decay curve in the irradiated crystals is attributed to the blocking of the energy transfer processes of V sub k lattice disorders, which were produced in irradiated crystals. The scintillation mechanism is affected in the crystal irradiated at 5x10 sup 5 Gy. However for crystals irradiated below 10 sup 5 Gy the mechanism process is not altered, and the decrease in the light output is due to internal transmission loss. It was also observed that the damage for irradiation is not permanent and it obeys a bi-exponential function.

  18. The Viability of a DTN System for Current Military Application

    Science.gov (United States)

    2013-03-01

    Agency (DARPA) Disruption-Tolerant Networking program and the Internet Research Task Force (IRTF) DTN Research Group made significant strides toward...Disruption-Tolerant Networks A Primer,” Interplanetary Internet Special Interest Group, 2012. [4] D. T. N. R. Group, “Compiling DTN2,” Internet Research Task

  19. A Model-based B2B (Batch to Batch) Control for An Industrial Batch Polymerization Process

    Science.gov (United States)

    Ogawa, Morimasa

    This paper describes overview of a model-based B2B (batch to batch) control for an industrial batch polymerization process. In order to control the reaction temperature precisely, several methods based on the rigorous process dynamics model are employed at all design stage of the B2B control, such as modeling and parameter estimation of the reaction kinetics which is one of the important part of the process dynamics model. The designed B2B control consists of the gain scheduled I-PD/II2-PD control (I-PD with double integral control), the feed-forward compensation at the batch start time, and the model adaptation utilizing the results of the last batch operation. Throughout the actual batch operations, the B2B control provides superior control performance compared with that of conventional control methods.

  20. Phenol wastewater remediation: advanced oxidation processes coupled to a biological treatment.

    Science.gov (United States)

    Rubalcaba, A; Suárez-Ojeda, M E; Stüber, F; Fortuny, A; Bengoa, C; Metcalfe, I; Font, J; Carrera, J; Fabregat, A

    2007-01-01

    Nowadays, there are increasingly stringent regulations requiring more and more treatment of industrial effluents to generate product waters which could be easily reused or disposed of to the environment without any harmful effects. Therefore, different advanced oxidation processes were investigated as suitable precursors for the biological treatment of industrial effluents containing phenol. Wet air oxidation and Fenton process were tested batch wise, while catalytic wet air oxidation and H2O2-promoted catalytic wet air oxidation processes were studied in a trickle bed reactor, the last two using over activated carbon as catalyst. Effluent characterisation was made by means of substrate conversion (using high liquid performance chromatography), chemical oxygen demand and total organic carbon. Biodegradation parameters (i.e. maximum oxygen uptake rate and oxygen consumption) were obtained from respirometric tests using activated sludge from an urban biological wastewater treatment plant (WWTP). The main goal was to find the proper conditions in terms of biodegradability enhancement, so that these phenolic effluents could be successfully treated in an urban biological WWTP. Results show promising research ways for the development of efficient coupled processes for the treatment of wastewater containing toxic or biologically non-degradable compounds.

  1. Linear parallel processing machines I

    Energy Technology Data Exchange (ETDEWEB)

    Von Kunze, M

    1984-01-01

    As is well-known, non-context-free grammars for generating formal languages happen to be of a certain intrinsic computational power that presents serious difficulties to efficient parsing algorithms as well as for the development of an algebraic theory of contextsensitive languages. In this paper a framework is given for the investigation of the computational power of formal grammars, in order to start a thorough analysis of grammars consisting of derivation rules of the form aB ..-->.. A/sub 1/ ... A /sub n/ b/sub 1/...b /sub m/ . These grammars may be thought of as automata by means of parallel processing, if one considers the variables as operators acting on the terminals while reading them right-to-left. This kind of automata and their 2-dimensional programming language prove to be useful by allowing a concise linear-time algorithm for integer multiplication. Linear parallel processing machines (LP-machines) which are, in their general form, equivalent to Turing machines, include finite automata and pushdown automata (with states encoded) as special cases. Bounded LP-machines yield deterministic accepting automata for nondeterministic contextfree languages, and they define an interesting class of contextsensitive languages. A characterization of this class in terms of generating grammars is established by using derivation trees with crossings as a helpful tool. From the algebraic point of view, deterministic LP-machines are effectively represented semigroups with distinguished subsets. Concerning the dualism between generating and accepting devices of formal languages within the algebraic setting, the concept of accepting automata turns out to reduce essentially to embeddability in an effectively represented extension monoid, even in the classical cases.

  2. Information Processing Techniques Program. Volume I. Packet Speech Systems Technology

    Science.gov (United States)

    1980-09-30

    Itindsign has litt-rn vt-tntit-r aliti sill dI- ditiibuted trrni cparat- tintr aisa ithnnin ITtc-i A. Packet Vttice Terminal As Iprt- iouisik rtrtteti tin...September 1980. FO1M 1473 EDITION OF I NOV 65 IS OBSOLETEDD I JAN 73 UNCLA.SSI F[IF ) SECURITY CLASSIFICATION OF THIS PAGE (Ibmn Data fntew-d)

  3. PREFACE: I International Scientific School Methods of Digital Image Processing in Optics and Photonics

    Science.gov (United States)

    Gurov, I. P.; Kozlov, S. A.

    2014-09-01

    The first international scientific school "Methods of Digital Image Processing in Optics and Photonics" was held with a view to develop cooperation between world-class experts, young scientists, students and post-graduate students, and to exchange information on the current status and directions of research in the field of digital image processing in optics and photonics. The International Scientific School was managed by: Saint Petersburg National Research University of Information Technologies, Mechanics and Optics (ITMO University) - Saint Petersburg (Russia) Chernyshevsky Saratov State University - Saratov (Russia) National research nuclear University "MEPHI" (NRNU MEPhI) - Moscow (Russia) The school was held with the participation of the local chapters of Optical Society of America (OSA), the Society of Photo-Optical Instrumentation Engineers (SPIE) and IEEE Photonics Society. Further details, including topics, committees and conference photos are available in the PDF

  4. Software tools for the simple processing of a real-time system input/output. Application to the survey/check of a ion source by a mini-computer

    International Nuclear Information System (INIS)

    Laudillay, Y.

    1979-01-01

    This I/0 software is composed by the set of modules allowing exchanges of data between computer and process to control. It is developed taking several types of problems into account. Particularly the use of I/0 must be easy for the pedestrian and I/0 system should be able to evolve because the number of parameters can increase or lessen and also, the characteristics of some parameters can change. The respect of these conditions requires some particular solutions. For example, it is preferable for the control process software to be written in high level language and the I/0 software to be accessible in this language. It is important, also that hardware and software intermediate levels for exchanges of data be easy for user writing a program. The other problems, typical of the real time check are determined by use of the computer standard I/0. However some further modules are necessary to obtain a real time I/0 system having satisfying performances [fr

  5. <i>Fucus> and <i>Ascophyllum> seaweeds are significant contributors to coastal iodine emissions

    OpenAIRE

    H. Berresheim; C. D. O'Dowd; F. C. Küpper; P. P. A. Smyth; J. Chen; A. L. Vogel; D. Ceburnis; D. S. Venables; M. Kundel; U. R. Thorenz; R.-J. Huang; T. Hoffmann

    2012-01-01

    Based on the results of a pilot study in 2007, which found high mixing ratios of molecular iodine (I2) above the intertidal macroalgae (seaweed) beds at Mweenish Bay (Ireland), we extended the study to nine different locations in the vicinity of Mace Head Atmospheric Research Station on the west coast of Ireland during a field campaign in 2009. I2 mixing ratios from 104 to 393 ppt were found above the macroalgae beds, implying a high source strength of I2. Such mixing ratios are suffic...

  6. METAL CHIP HEATING PROCESS INVESTIGATION (Part I

    Directory of Open Access Journals (Sweden)

    O. M. Dyakonov

    2007-01-01

    Full Text Available The main calculation methods for heat- and mass transfer in porous heterogeneous medium have been considered. The paper gives an evaluation of the possibility to apply them for calculation of metal chip heating process. It has been shown that a description of transfer processes in a chip has its own specific character that is attributed to difference between thermal and physical properties of chip material and lubricant-coolant components on chip surfaces. It has been determined that the known expressions for effective heat transfer coefficients can be used as basic ones while approaching mutually penetrating continuums. A mathematical description of heat- and mass transfer in chip medium can be considered as a basis of mathematical modeling, numerical solution and parameter optimization of the mentioned processes.

  7. Process-Structure Linkages Using a Data Science Approach: Application to Simulated Additive Manufacturing Data

    International Nuclear Information System (INIS)

    Popova, Evdokia; Rodgers, Theron M.; Gong, Xinyi; Cecen, Ahmet; Madison, Jonathan D.; Kalidindi, Surya R.

    2017-01-01

    A novel data science workflow is developed and demonstrated to extract process-structure linkages (i.e., reduced-order model) for microstructure evolution problems when the final microstructure depends on (simulation or experimental) processing parameters. Our workflow consists of four main steps: data pre-processing, microstructure quantification, dimensionality reduction, and extraction/validation of process-structure linkages. These methods that can be employed within each step vary based on the type and amount of available data. In this paper, this data-driven workflow is applied to a set of synthetic additive manufacturing microstructures obtained using the Potts-kinetic Monte Carlo (kMC) approach. Additive manufacturing techniques inherently produce complex microstructures that can vary significantly with processing conditions. Using the developed workflow, a low-dimensional data-driven model was established to correlate process parameters with the predicted final microstructure. In addition, the modular workflows developed and presented in this work facilitate easy dissemination and curation by the broader community.

  8. Think-aloud process superior to thought-listing in increasing children’s critical processing of advertising

    NARCIS (Netherlands)

    Rozendaal, E.; Buijzen, M.; Valkenburg, P.M.

    2012-01-01

    This study develops and tests a model of children's critical processing of advertising. Within this model, 2 paths to reduced advertising susceptibility (i.e., attitude toward the advertised brand) were hypothesized: a cognitive path and an affective path. The secondary aim was to compare these

  9. Dangerous poverty. Analysis of the criminalization process of poverty and youth in Uruguay and of the challenges that this process presents to the community psychology

    Directory of Open Access Journals (Sweden)

    Agustín Cano Menoni

    2014-02-01

    Full Text Available In this paper I analyze the components and main effects of what I characterized as a process of criminalization of youth in poverty, in the case of Uruguay. I argue that this process occurs through a series of discursive operations (in different levels: police, judicial, political and technical- scientific, which stigmatize the social reference group, placing them as a threat to society. To investigate this process, I analyze journalistic texts, testimonials and an advertising campaign, covering the following actors: a member of the national Parliament, the editorialist of the highest circulation newspaper in Uruguay, the Director of the largest hospice psychiatric in the country, and the Uruguayan Interior Ministry (police force. I conclude that in Uruguay started up a stigmatization process which place youth in poverty as a threat to society, and that this process involves the deepening of police approaches of the security problems, obscuring the conditions of social injustice behind them, and consecrating fear as the main principle of the social relationships. This situation also challenges to the social sciences, and in particular to psycological disciplines, by posing the challenge of finding new answers, both theoretical and methodological, alternatives to the stigmatization and police security approaches.

  10. Barriers to the Integration and Adoption of iPads in Schools

    DEFF Research Database (Denmark)

    Khalid, Md. Saifuddin; Kilic, Gökce; Christoffersen, Jeanette

    2015-01-01

    iPad, with its Apple platform and interoperability-dependent material conditions, bring complex barriers in its adoption and integration in secondary education system as a learning tool. In the schools’ context, it is an emerging educational technology for its affordances supporting collaborative...... learning. This systematic literature review on the barriers to the integration of iPad in primary and secondary schools is based on 13 peer-reviewed and full-text articles. The paper discusses what are the challenges in using iPad as a learning tool in primary and secondary educational settings....... The identified barriers are discussed in three broad categories or stages of innovation process in an educational context: basic challenges with the tool, barriers to the integration of the iPad in a school setting, and barriers in the use of the iPad....

  11. Spatial patterns and infestation processes in the horse chestnut leafminer .I.Cameraria ohridella./I.: a tale of two cities

    Czech Academy of Sciences Publication Activity Database

    Gibert, M.; Svatoš, Aleš; Lehmann, M.; Bacher, S.

    2003-01-01

    Roč. 107, - (2003), s. 25-27 ISSN 0013-8703 Grant - others:Controcam(XE) QLK5-CT-2000-01684; Swiss Ministry for Education and Science(CH) BBW99.0830-2 Institutional research plan: CEZ:AV0Z4055905 Keywords : .I.Cameraria ohridella./I. * Biological invasion * sex pheromone Subject RIV: CC - Organic Chemistry Impact factor: 0.850, year: 2003

  12. Magnitude of Alloresponses to MHC Class I/II Expressing Human Cardiac Myocytes is Limited by their Intrinsic Ability to Process and Present Antigenic Peptides

    Directory of Open Access Journals (Sweden)

    Aftab A. Ansari

    2003-01-01

    Full Text Available In this investigation we have explored the relationship between the weak allogenicity of cardiac myocytes and their capacity to present allo-antigens by examining the ability of a human cardiac myocyte cell line (W-1 to process and present nominal antigens. W-1 cells (HLA-A*0201 and HLA-DR β1*0301 pulsed with the influenza A matrix 1 (58-66 peptide (M1 were able to serve as targets for the HLA-A*0201 restricted CTL line PG, specific for M1-peptide. However, PG-CTLs were unable to lyse W-1 target cells infected with a recombinant vaccinia virus expressing the M1 protein (M1-VAC. Pretreatment of these M1-VAC targets with IFN-γ partially restored their ability to process and present the M1 peptide. However, parallel studies demonstrated that IFN-γ pretreated W-1's could not process tetanus toxin (TT or present the TT(830-843 peptide to HLA-DR3 restricted TT-primed T cells. Semi-quantitative RT-PCR measurements revealed significantly lower constitutive levels of expression for MHC class I, TAP-1/2, and LMP-2/7 genes in W-1s that could be elevated by pretreatment with IFN-γ to values equal to or greater than those expressed in EBV-PBLs. However, mRNA levels for the genes encoding MHC class II, Ii, CIITA, and DMA/B were markedly lower in both untreated and IFN-γ pretreated W-1s relative to EBV-PBLs. Furthermore, pulse-chase analysis of the corresponding genes revealed significantly lower protein levels and longer half-life expression in W-1s relative to EBV-PBLs. These results suggest that weak allogenicity of cardiac myocytes may be governed by their limited expression of MHC genes and gene products critical for antigen processing and presentation.

  13. Criteria for prediction of plastic instabilities for hot working processes. (Part I: Theoretical review)

    International Nuclear Information System (INIS)

    Al Omar, A.; Prado, J. M.

    2010-01-01

    Hot working processes often induce high levels of deformation at high strain rates, and impose very complex multiaxial modes of solicitation. These processes are essentially limited by apparition and development of plastic instabilities. These may be the direct cause of rapid crack propagation, which lead to a possible final rupture. The complexity of deformation modes and the simultaneous intervention of several parameters have led many researchers to develop various criteria, with different approaches, to predict the occurrence of defects and to optimize process control parameters. The aim of the present paper is to summarize the general characteristics of some instability criteria, widely used in the literature, for the prediction of plastic instabilities during hot working. It was considered appropriate to divide the work into two parts: part I presents the phenomenological criteria for the prediction of plastic instabilities, based on descriptive observation of microscopic phenomena of the deformation (strain hardening and strain rate sensitivity), and discusses the continuum criteria based on the principle of maximum rate of entropy production of irreversible thermodynamics applied to continuum mechanics of large plastic flow. Also, this part provides a bibliographical discussion among several authors with regard to the physical foundations of dynamic materials model. In part II, of the work, a comparative study has been carried out to characterize the flow instability during a hot working process of a medium carbon microalloyed using phenomenological and continuum criteria. (Author) 83 refs.

  14. A Comparison of the Capabilities of Four Command and Control Systems at the Platoon Level and Below

    National Research Council Canada - National Science Library

    Sterling, Bruce

    2004-01-01

    ...; situational awareness; and workload. The Defense Advanced Research Projects Agency (DARPA) future C2 (FC2) system, judged by far the best on critical functions and CIR, had the best rated situational awareness...

  15. Kinetics of the processes, plasma parameters, and output characteristics of a UV emitter operating on XeI molecules and iodine molecules and atoms

    Energy Technology Data Exchange (ETDEWEB)

    Shuaibov, A. K.; Grabovaya, I. A.; Minya, A. I.; Homoki, Z. T. [Uzhgorod National University (Ukraine); Kalyuzhnaya, A. G.; Shchedrin, A. I. [National Academy of Sciences of Ukraine, Institute of Physics (Ukraine)

    2011-03-15

    A kinetic model of the processes occurring in the plasma of a high-power low-pressure gas-discharge lamp is presented, and the output characteristics of the lamp are described. The lamp is excited by a longitudinal glow discharge and emits the I{sub 2}(D Prime -A Prime ) 342-nm and XeI(B-X) 253-nm bands and the 206.2-nm spectral line of atomic iodine. When the emitter operates in a sealed-off mode on the p(He): p(Xe): p(I{sub 2}) = 400: 120: (100-200) Pa mixture, the fractions of the UV radiation power of iodine atoms, exciplex molecules of xenon iodide, and iodine molecules comprise 55, 10, and 35%, respectively. At the optimal partial pressure, the maximum total radiation power of the lamp reaches 37 W, the energy efficiency being about 15%.

  16. Room temperature solution processed low dimensional CH3NH3PbI3 NIR detector

    Science.gov (United States)

    Besra, N.; Paul, T.; Sarkar, P. K.; Thakur, S.; Sarkar, S.; Das, A.; Chanda, K.; Sardar, K.; Chattopadhyay, K. K.

    2018-05-01

    Metal halide perovskites have recently drawn immense research interests among the worldwide scientific community due to their excellent light harvesting capabilities and above all, cost effectiveness. These new class of materials have already been used as efficient optoelectronic devices e.g. solar cells, photo detectors, etc. Here in this work, room temperature NIR (near infra red) response of organic-inorganic lead halide perovskite CH3NH3PbI3 (Methylammonium lead tri iodide) nanorods has been studied. A very simple solution process technique has been adopted to synthesize CH3NH3PbI3 nanostructures at room temperature. The NIR exposure upon the sample resulted in a considerable hike in its dark current with very good responsivity (0.37 mA/W). Along with that, a good on-off ratio (41.8) was also obtained when the sample was treated under a pulsed NIR exposure with operating voltage of 2 V. The specific detectivity of the device came in the order of 1010 Jone.

  17. Idaho Chemical Processing Plant Process Efficiency improvements

    International Nuclear Information System (INIS)

    Griebenow, B.

    1996-03-01

    In response to decreasing funding levels available to support activities at the Idaho Chemical Processing Plant (ICPP) and a desire to be cost competitive, the Department of Energy Idaho Operations Office (DOE-ID) and Lockheed Idaho Technologies Company have increased their emphasis on cost-saving measures. The ICPP Effectiveness Improvement Initiative involves many activities to improve cost effectiveness and competitiveness. This report documents the methodology and results of one of those cost cutting measures, the Process Efficiency Improvement Activity. The Process Efficiency Improvement Activity performed a systematic review of major work processes at the ICPP to increase productivity and to identify nonvalue-added requirements. A two-phase approach was selected for the activity to allow for near-term implementation of relatively easy process modifications in the first phase while obtaining long-term continuous improvement in the second phase and beyond. Phase I of the initiative included a concentrated review of processes that had a high potential for cost savings with the intent of realizing savings in Fiscal Year 1996 (FY-96.) Phase II consists of implementing long-term strategies too complex for Phase I implementation and evaluation of processes not targeted for Phase I review. The Phase II effort is targeted for realizing cost savings in FY-97 and beyond

  18. Diversity of natural self-derived ligands presented by different HLA class I molecules in transporter antigen processing-deficient cells.

    Directory of Open Access Journals (Sweden)

    Elena Lorente

    Full Text Available The transporter associated with antigen processing (TAP translocates the cytosol-derived proteolytic peptides to the endoplasmic reticulum lumen where they complex with nascent human leukocyte antigen (HLA class I molecules. Non-functional TAP complexes and viral or tumoral blocking of these transporters leads to reduced HLA class I surface expression and a drastic change in the available peptide repertoire. Using mass spectrometry to analyze complex human leukocyte antigen HLA-bound peptide pools isolated from large numbers of TAP-deficient cells, we identified 334 TAP-independent ligands naturally presented by four different HLA-A, -B, and -C class I molecules with very different TAP dependency from the same cell line. The repertoire of TAP-independent peptides examined favored increased peptide lengths and a lack of strict binding motifs for all four HLA class I molecules studied. The TAP-independent peptidome arose from 182 parental proteins, the majority of which yielded one HLA ligand. In contrast, TAP-independent antigen processing of very few cellular proteins generated multiple HLA ligands. Comparison between TAP-independent peptidome and proteome of several subcellular locations suggests that the secretory vesicle-like organelles could be a relevant source of parental proteins for TAP-independent HLA ligands. Finally, a predominant endoproteolytic peptidase specificity for Arg/Lys or Leu/Phe residues in the P(1 position of the scissile bond was found for the TAP-independent ligands. These data draw a new and intricate picture of TAP-independent pathways.

  19. Proceedings of Joint RL/AFOSR Workshop on Intelligent Information Systems Held at Griffiss AFB, New York on October 22-23, 1991

    Science.gov (United States)

    1992-04-01

    OF PENNSYLVANIA F. "HErEROGENOUS KNOWLEDGE BASES" GIO WIEDERHOLD, DARPA G. "SIMS: SERVICES AND INFORMATION MANAGEMENT FOR DECISION SUPPORT", YIGAL...Pennsylvania 9:00 - 9:30 "Heterogenous Knowledge Bases", Gio Wiederhold - Darpa iv 9:30 - 9:45 Break 9:45 - 10:15 "Services and Information Management ...Ohio Sam University Met;tphors fir Problem Solving in Al Reasoning Deliberation - Knowlede Rules of Inference Problem Solving - Initial state - Goal

  20. iMS2Flux – a high–throughput processing tool for stable isotope labeled mass spectrometric data used for metabolic flux analysis

    Directory of Open Access Journals (Sweden)

    Poskar C Hart

    2012-11-01

    Full Text Available Abstract Background Metabolic flux analysis has become an established method in systems biology and functional genomics. The most common approach for determining intracellular metabolic fluxes is to utilize mass spectrometry in combination with stable isotope labeling experiments. However, before the mass spectrometric data can be used it has to be corrected for biases caused by naturally occurring stable isotopes, by the analytical technique(s employed, or by the biological sample itself. Finally the MS data and the labeling information it contains have to be assembled into a data format usable by flux analysis software (of which several dedicated packages exist. Currently the processing of mass spectrometric data is time-consuming and error-prone requiring peak by peak cut-and-paste analysis and manual curation. In order to facilitate high-throughput metabolic flux analysis, the automation of multiple steps in the analytical workflow is necessary. Results Here we describe iMS2Flux, software developed to automate, standardize and connect the data flow between mass spectrometric measurements and flux analysis programs. This tool streamlines the transfer of data from extraction via correction tools to 13C-Flux software by processing MS data from stable isotope labeling experiments. It allows the correction of large and heterogeneous MS datasets for the presence of naturally occurring stable isotopes, initial biomass and several mass spectrometry effects. Before and after data correction, several checks can be performed to ensure accurate data. The corrected data may be returned in a variety of formats including those used by metabolic flux analysis software such as 13CFLUX, OpenFLUX and 13CFLUX2. Conclusion iMS2Flux is a versatile, easy to use tool for the automated processing of mass spectrometric data containing isotope labeling information. It represents the core framework for a standardized workflow and data processing. Due to its flexibility

  1. Routes to Chaos Induced by a Discontinuous Resetting Process in a Hybrid Spiking Neuron Model.

    Science.gov (United States)

    Nobukawa, Sou; Nishimura, Haruhiko; Yamanishi, Teruya

    2018-01-10

    Several hybrid spiking neuron models combining continuous spike generation mechanisms and discontinuous resetting processes following spiking have been proposed. The Izhikevich neuron model, for example, can reproduce many spiking patterns. This model clearly possesses various types of bifurcations and routes to chaos under the effect of a state-dependent jump in the resetting process. In this study, we focus further on the relation between chaotic behaviour and the state-dependent jump, approaching the subject by comparing spiking neuron model versions with and without the resetting process. We first adopt a continuous two-dimensional spiking neuron model in which the orbit in the spiking state does not exhibit divergent behaviour. We then insert the resetting process into the model. An evaluation using the Lyapunov exponent with a saltation matrix and a characteristic multiplier of the Poincar'e map reveals that two types of chaotic behaviour (i.e. bursting chaotic spikes and near-period-two chaotic spikes) are induced by the resetting process. In addition, we confirm that this chaotic bursting state is generated from the periodic spiking state because of the slow- and fast-scale dynamics that arise when jumping to the hyperpolarization and depolarization regions, respectively.

  2. I'm a Guy. How Can I Talk to My Female Doctor about Certain Things?

    Science.gov (United States)

    ... Español I'm a Guy. How Can I Talk to My Female Doctor About Certain Things? KidsHealth / ... site. Note: All information on TeensHealth® is for educational purposes only. For specific medical advice, diagnoses, and ...

  3. Instrumentation database specific to Trillo I NPP

    International Nuclear Information System (INIS)

    Pereira Pagan, M.B.; Saenz de Tejada, P.; Fernandez Alvarez, A.; Haya, J.

    1997-01-01

    The analysis of data on electronic instrumentation components in the Trillo I PSA has involved and extra effort, basically due to the particular characteristics of these equipment items. This analysis has different aspects depending on the type of information used: Components whose data have been obtained from generic information sources (with or without Bayesian processing). Components whose data have been obtained from specific German studies (TUV) Components whose data have been based directly on the historical experience of Trillo I NPP Components whose data have been based on miscellaneous generic and specific sources This information can also be classified into: Micro components formed by a single module ar card Micro components: formed by set of instrumentation elements It can be further subdivided according to the operating conditions of the components: Equipment whose operation depends on the functions they perform in a particular system (eg. reactor protection system instrumentation channels) Equipment whose operation is not associated with particular conditions (eg. modules for motor-operated equipment). (Author)

  4. A simple guide to iPhone 5

    CERN Document Server

    Lett, Mary

    2012-01-01

    From basics such as voice mail, text messaging, and GPS to the newest and coolest apps, this straightforward user's guide helps readers customize their iPhone 5 for optimum productivity and fun. The book discusses how to customize home and lock screens and ring tones, take pictures and video, and use the App Store, while explaining the nuances of functions that help maximize readers' business and personal time. The impressive capabilities of the iPhone 5 are laid bare in this engaging manual.

  5. Using a micro-molding process to fabricate polymeric wavelength filters

    Science.gov (United States)

    Chuang, Wei-Ching; Lee, An-Chen; Ho, Chi-Ting

    2008-08-01

    A procedure for fabricating a high aspect ratio periodic structure on a UV polymer at submicron order using holographic interferometry and molding processes is described. First, holographic interferometry using a He-Cd (325 nm) laser was used to create the master of the periodic line structure on an i-line sub-micron positive photoresist film. A 20 nm nickel thin film was then sputtered on the photoresist. The final line pattern on a UV polymer was obtained from casting against the master mold. Finally, a SU8 polymer was spun on the polymer grating to form a planar waveguide or a channel waveguide. The measurement results show that the waveguide length could be reduced for the waveguide having gratings with a high aspect ratio.

  6. New challenges to public utilities. Shaping change - first German I.I.R. energy congress in Wiesbaden on 21/22 March 1995; Neue Herausforderungen in der Versorgungswirtschaft. Den Wandel gestalten - 1. Deutscher I.I.R.-Energiekongress am 21./22. Maerz 1995 in Wiesbaden

    Energy Technology Data Exchange (ETDEWEB)

    Lamprecht, F

    1995-05-01

    The issues discussed at the First German I.I.R. Energy Congress comprise various aspects of a public supplies system undergoing conversion: changed framework conditions; customer grooming measures in core business areas; diversification into appropriate new fields of business; consequences of these processes for personnel management; and steering and control of the transformation process through efficient Controlling. The congress was organised jointly by the Institute for International Research (I.I.R.) and ``et``. It attracted around 250 participants and was flanked by the proclamation of the 1995 Energy Management Award. (orig.) [Deutsch] Aktuelle Aspekte der Versorgungswirtschaft im Umbruch, von den veraenderten Rahmenbedingungen ueber Kundenbindungsmassnahmen im Stammgeschaeft, Diversifikation in geeignete neue Geschaeftsfelder, die Konsequenzen dieser Prozesse fuer die Personalwirtschaft, bis zur Steuerung und Kontrolle der Transformation durch effizientes Controlling, waren Thema des 1. Deutschen I.I.R.-Energiekongresses, gemeinsam ausgerichtet vom Institute for International Research (I.I.R) und der ``et``. Die Verleihung des Energie Management Award `95 sowie eine Fachausstellung flankierten die von rund 250 Teilnehmern besuchte Veranstaltung. (orig.)

  7. Pedestrians' intention to jaywalk: Automatic or planned? A study based on a dual-process model in China.

    Science.gov (United States)

    Xu, Yaoshan; Li, Yongjuan; Zhang, Feng

    2013-01-01

    The present study investigates the determining factors of Chinese pedestrians' intention to violate traffic laws using a dual-process model. This model divides the cognitive processes of intention formation into controlled analytical processes and automatic associative processes. Specifically, the process explained by the augmented theory of planned behavior (TPB) is controlled, whereas the process based on past behavior is automatic. The results of a survey conducted on 323 adult pedestrian respondents showed that the two added TPB variables had different effects on the intention to violate, i.e., personal norms were significantly related to traffic violation intention, whereas descriptive norms were non-significant predictors. Past behavior significantly but uniquely predicted the intention to violate: the results of the relative weight analysis indicated that the largest percentage of variance in pedestrians' intention to violate was explained by past behavior (42%). According to the dual-process model, therefore, pedestrians' intention formation relies more on habit than on cognitive TPB components and social norms. The implications of these findings for the development of intervention programs are discussed. Copyright © 2012 Elsevier Ltd. All rights reserved.

  8. Preliminary evaluation of alternative waste form solidification processes. Volume I. Identification of the processes

    International Nuclear Information System (INIS)

    Treat, R.L.; Nesbitt, J.F.; Blair, H.T.; Carter, J.G.; Gorton, P.S.; Partain, W.L.; Timmerman, C.L.

    1980-04-01

    This document contains preconceptual design data on 11 processes for the solidification and isolation of nuclear high-level liquid wastes (HLLW). The processes are: in-can glass melting (ICGM) process, joule-heated glass melting (JHGM) process, glass-ceramic (GC) process, marbles-in-lead (MIL) matrix process, supercalcine pellets-in-metal (SCPIM) matrix process, pyrolytic-carbon coated pellets-in-metal (PCCPIM) matrix process, supercalcine hot-isostatic-pressing (SCHIP) process, SYNROC hot-isostatic-pressing (SYNROC HIP) process, titanate process, concrete process, and cermet process. For the purposes of this study, it was assumed that each of the solidification processes is capable of handling similar amounts of HLLW generated in a production-sized fuel reprocessing plant. It was also assumed that each of the processes would be enclosed in a shielded canyon or cells within a waste facility located at the fuel reprocessing plant. Finally, it was assumed that all of the processes would be subject to the same set of regulations, codes and standards. Each of the solidification processes converts waste into forms that may be acceptable for geological disposal. Each process begins with the receipt of HLLW from the fuel reprocessing plant. In this study, it was assumed that the original composition of the HLLW would be the same for each process. The process ends when the different waste forms are enclosed in canisters or containers that are acceptable for interim storage. Overviews of each of the 11 processes and the bases used for their identification are presented in the first part of this report. Each process, including its equipment and its requirements, is covered in more detail in Appendices A through K. Pertinent information on the current state of the art and the research and development required for the implementation of each process are also noted in the appendices

  9. An information theory-based approach to modeling the information processing of NPP operators

    International Nuclear Information System (INIS)

    Kim, Jong Hyun; Seong, Poong Hyun

    2002-01-01

    This paper proposes a quantitative approach to modeling the information processing of NPP operators. The aim of this work is to derive the amount of the information processed during a certain control task. The focus will be on i) developing a model for information processing of NPP operators and ii) quantifying the model. To resolve the problems of the previous approaches based on the information theory, i.e. the problems of single channel approaches, we primarily develop the information processing model having multiple stages, which contains information flows. Then the uncertainty of the information is quantified using the Conant's model, a kind of information theory

  10. Processer og metoder i det fejlfrie byggeri

    DEFF Research Database (Denmark)

    Jørgensen, Kirsten; Schultz, Casper Siebken; Bonke, Sten

    -sjusk. I 2006 kunne BEC, Byggeriets Evaluerings Center, vise den første reelle opgørelse over registrere-de mangler ved aflevering blandt de evaluerede byggerier. Det førte til en offentlig debat og en del reaktioner fra byggeriets parter. I en efterfølgende dialog mellem Sven Bertelsen fra Lean Construc...... erfaringsbaseret for-ståelsesgrundlag for, ”hvordan de bedste projektledere gennemfører den gode byggeproces”. Med andre ord en beretning om ’best practice’, set ud fra et bestemt aktørperspektiv. Undervejs kom der øget fokus på betydningen af forskellige entrepriseformer, hvilket gav anledning til inddragelse af...

  11. Biomolecular Modeling in a Process Dynamics and Control Course

    Science.gov (United States)

    Gray, Jeffrey J.

    2006-01-01

    I present modifications to the traditional course entitled, "Process dynamics and control," which I renamed "Modeling, dynamics, and control of chemical and biological processes." Additions include the central dogma of biology, pharmacokinetic systems, population balances, control of gene transcription, and large­-scale…

  12. Prepulse inhibition is associated with attention, processing speed, and 123I-FP-CIT SPECT in Parkinson's disease

    DEFF Research Database (Denmark)

    Zoetmulder, Marielle; Biernat, Heidi B; Nikolic, Miki

    2014-01-01

    BACKGROUND: Prepulse inhibition is a measure of sensorimotor gating, which reflects the ability to filter or 'gate' irrelevant information. Prepulse inhibition is dramatically altered in basal ganglia disorders associated with dysfunction in the midbrain dopaminergic system, and corresponding......'s disease have been extensively studied in relation to motor function, less is known about the potential role of sensorimotor processes in cognitive function. OBJECTIVE: We investigated the relationship between prepulse inhibition, cognition and nigrostriatal dysfunction, as measured with 123I......-FP-CIT-SPECT scanning, in patients with Parkinson's disease. METHODS: 38 Parkinson patients were assessed with prepulse inhibition, neuropsychological tests, and neurological investigation. A subset of these patients underwent 123I-FP-CIT-SPECT scanning. RESULTS: Patients with a higher level of prepulse inhibition...

  13. Leveraging iPads to introduce meditation and reduce distress among cancer patients undergoing chemotherapy: a promising approach.

    Science.gov (United States)

    Millegan, Jeffrey; Manschot, Bernard; Dispenzieri, Monica; Marks, Benjamin; Edwards, Ayesha; Raulston, Vanessa; Khatiwoda, Yojana; Narro, Marlo

    2015-12-01

    Distress is common among cancer patients. Regular meditation practice has the potential to mitigate this distress and improve quality of life for this population. Introducing meditation to cancer patients can be particularly challenging given the demands on patients' time from treatment and normal life events. This internal process improvement study examined the potential benefit of utilizing iPads during chemotherapy sessions to introduce meditation and reduce distress. Patients undergoing chemotherapy infusion were offered iPads with various meditation videos and audio files during the session. Levels of distress were measured using the distress thermometer at the beginning of chemotherapy and at the conclusion of chemotherapy. Seventy-three patients accepted the meditation iPads during the chemotherapy session. Among those who accepted the iPads, average distress dropped 46% by the end of the session (p meditation as a stress management tool for people with cancer.

  14. I am active”: effects of a program to promote active aging

    Science.gov (United States)

    Mendoza-Ruvalcaba, Neyda Ma; Arias-Merino, Elva Dolores

    2015-01-01

    Background Active aging involves a general lifestyle strategy that allows preservation of both physical and mental health during the aging process. “I am Active” is a program designed to promote active aging by increased physical activity, healthy nutritional habits, and cognitive functioning. The purpose of this study was to assess the effectiveness of this program. Methods Sixty-four healthy adults aged 60 years or older were recruited from senior centers and randomly allocated to an experimental group (n=31) or a control group (n=33). Baseline, post-test, and 6-month follow-up assessments were performed after the theoretical–practical intervention. Effect sizes were calculated. Results At the conclusion of the program, the experimental group showed significant improvement compared with the control group in the following domains: physical activity (falls risk, balance, flexibility, self-efficacy), nutrition (self-efficacy and nutritional status), cognitive performance (processing speed and self-efficacy), and quality of life (general, health and functionality, social and economic status). Although some declines were reported, improvements at follow-up remained in self-efficacy for physical activity, self-efficacy for nutrition, and processing speed, and participants had better nutritional status and quality of life overall. Conclusion Our findings show that this program promotes improvements in domains of active aging, mainly in self-efficacy beliefs as well as in quality of life in healthy elders. PMID:26005337

  15. Electric field-induced hole transport in copper(i) thiocyanate (CuSCN) thin-films processed from solution at room temperature

    KAUST Repository

    Pattanasattayavong, Pichaya; Ndjawa, Guy Olivier Ngongang; Zhao, Kui; Chou, Kang Wei; Yaacobi-Gross, Nir; O'Regan, Brian C.; Amassian, Aram; Anthopoulos, Thomas D.

    2013-01-01

    The optical, structural and charge transport properties of solution-processed films of copper(i) thiocyanate (CuSCN) are investigated in this work. As-processed CuSCN films of ∼20 nm in thickness are found to be nano-crystalline, highly transparent and exhibit intrinsic hole transporting characteristics with a maximum field-effect mobility in the range of 0.01-0.1 cm2 V-1 s-1. © 2013 The Royal Society of Chemistry.

  16. U. S. Navy’s Superconductivity Programs; Scientific Curosity To Fleet Utility

    Science.gov (United States)

    2010-10-01

    calculating superconducting properties from first principles . In 1974 they published their first PRL, demonstrating a quantitative evaluation of the...scientists became managers of the new SDIO program of HTS applications (Gubser, Nisenoff), and primary consultants on the new DARPA HTS program...B.A. Bender, M.S. Osofsky, R.J. Soulen Jr., W.L. Lechter, N.C. Koon , S.A. Wolf; Journal of Superconductivity 2 (2), p. 253 (1989). 36. W. J

  17. Thermal sensitivity of excitation-contraction-coupling in a chill susceptible insect, <i>Locusta migratoriai>

    DEFF Research Database (Denmark)

    Findsen, Anders; Pedersen, Thomas Holm; Overgaard, Johannes

    Many insect species enter a state of neuromuscular paralysis when their body temperature is lowered to a critical limit but the physiological and cellular processes underlying this chill coma are largely unknown. Previous studies on locusts show that muscle force production is highly depressed...... at low temperature implicating impairment in cellular mechanism in the muscle per se. Aiming to determine these mechanisms we examined the thermal sensitivity of several events in the excitation-contraction-coupling process including: i) Passive membrane properties and propagation of electrical signals...

  18. Occupational exposure to {sup 99m}Tc and {sup 131}I in a radiopharmacy room

    Energy Technology Data Exchange (ETDEWEB)

    Valle, Bruna P.; Cunha, Kenya Dias da; Sa, Lidia Vasconcellos de; Souza, Wanderson; Santos, Maristela; Medeiras, Geiza; Conceicao, Cirilo S. [Universidade do Estado, Nova Friburgo, RJ (Brazil). Inst. Politecnico. Dept. de Modelagem Computacional], e-mail: brunapvalle@gmail.com, e-mail: kenya@ird.gov.br, e-mail: lidia@ird.gov.br, e-mail: wander@ird.gov.br, e-mail: mstela@ird.gov.br; Abrantes, Marcio Borges de [Centro de Medicina Nuclear Guanabara, Rio de Janeiro, RJ (Brazil)], e-mail: marcioabrantes@pop.com.br

    2009-07-01

    Brazil has about 310 nuclear medicine services and 90% of these services use Molybdenum/Technetium generators to prepare several radiopharmaceuticals to diagnostics; about 70% use also {sup 131}I for diagnosis and therapy. These radionuclides are associated to compounds in liquid form and during the manipulation to prepare and administer the patient dose some radioactive airborne particle can be generated. As consequence the workers can be exposed to airborne particles in the respirable fraction containing {sup 99m}Tc and {sup 131}I. The aim of this study is develop a simple and rapid method to verify if the exhaust systems installed in the SMN are efficient in preventing the inhalation of radionuclides airborne particles by workers. In order to estimate the occupational exposure a nuclear medicine service was selected and aerosol samples were collected using personal air sampler with a cyclone. The samples were analyzed using a germanium detector system and the {sup 99m}Tc and {sup 131}I average concentrations were obtained as 16,6 {+-} 14,34 mBq/m{sup 3} and 0.72 {+-} 0.36 mBq/m{sup 3}, respectively. It was not observed a correlation among air concentration and total activity processed in laboratory. These results show that the worker inhales airborne particles containing {sup 99m}Tc and {sup 131}I. (author)

  19. Suppressive mechanisms in visual motion processing: From perception to intelligence.

    Science.gov (United States)

    Tadin, Duje

    2015-10-01

    Perception operates on an immense amount of incoming information that greatly exceeds the brain's processing capacity. Because of this fundamental limitation, the ability to suppress irrelevant information is a key determinant of perceptual efficiency. Here, I will review a series of studies investigating suppressive mechanisms in visual motion processing, namely perceptual suppression of large, background-like motions. These spatial suppression mechanisms are adaptive, operating only when sensory inputs are sufficiently robust to guarantee visibility. Converging correlational and causal evidence links these behavioral results with inhibitory center-surround mechanisms, namely those in cortical area MT. Spatial suppression is abnormally weak in several special populations, including the elderly and individuals with schizophrenia-a deficit that is evidenced by better-than-normal direction discriminations of large moving stimuli. Theoretical work shows that this abnormal weakening of spatial suppression should result in motion segregation deficits, but direct behavioral support of this hypothesis is lacking. Finally, I will argue that the ability to suppress information is a fundamental neural process that applies not only to perception but also to cognition in general. Supporting this argument, I will discuss recent research that shows individual differences in spatial suppression of motion signals strongly predict individual variations in IQ scores. Copyright © 2015 The Authors. Published by Elsevier Ltd.. All rights reserved.

  20. A General Purpose Feature Extractor for Light Detection and Ranging Data

    Directory of Open Access Journals (Sweden)

    Edwin B. Olson

    2010-11-01

    Full Text Available Feature extraction is a central step of processing Light Detection and Ranging (LIDAR data. Existing detectors tend to exploit characteristics of specific environments: corners and lines from indoor (rectilinear environments, and trees from outdoor environments. While these detectors work well in their intended environments, their performance in different environments can be poor. We describe a general purpose feature detector for both 2D and 3D LIDAR data that is applicable to virtually any environment. Our method adapts classic feature detection methods from the image processing literature, specifically the multi-scale Kanade-Tomasi corner detector. The resulting method is capable of identifying highly stable and repeatable features at a variety of spatial scales without knowledge of environment, and produces principled uncertainty estimates and corner descriptors at same time. We present results on both software simulation and standard datasets, including the 2D Victoria Park and Intel Research Center datasets, and the 3D MIT DARPA Urban Challenge dataset.

  1. A general purpose feature extractor for light detection and ranging data.

    Science.gov (United States)

    Li, Yangming; Olson, Edwin B

    2010-01-01

    Feature extraction is a central step of processing Light Detection and Ranging (LIDAR) data. Existing detectors tend to exploit characteristics of specific environments: corners and lines from indoor (rectilinear) environments, and trees from outdoor environments. While these detectors work well in their intended environments, their performance in different environments can be poor. We describe a general purpose feature detector for both 2D and 3D LIDAR data that is applicable to virtually any environment. Our method adapts classic feature detection methods from the image processing literature, specifically the multi-scale Kanade-Tomasi corner detector. The resulting method is capable of identifying highly stable and repeatable features at a variety of spatial scales without knowledge of environment, and produces principled uncertainty estimates and corner descriptors at same time. We present results on both software simulation and standard datasets, including the 2D Victoria Park and Intel Research Center datasets, and the 3D MIT DARPA Urban Challenge dataset.

  2. The impact of (n, γ) reaction rate uncertainties of unstable isotopes near N = 50 on the i-process nucleosynthesis in He-shell flash white dwarfs

    Science.gov (United States)

    Denissenkov, Pavel; Perdikakis, Georgios; Herwig, Falk; Schatz, Hendrik; Ritter, Christian; Pignatari, Marco; Jones, Samuel; Nikas, Stylianos; Spyrou, Artemis

    2018-05-01

    The first-peak s-process elements Rb, Sr, Y and Zr in the post-AGB star Sakurai's object (V4334 Sagittarii) have been proposed to be the result of i-process nucleosynthesis in a post-AGB very-late thermal pulse event. We estimate the nuclear physics uncertainties in the i-process model predictions to determine whether the remaining discrepancies with observations are significant and point to potential issues with the underlying astrophysical model. We find that the dominant source in the nuclear physics uncertainties are predictions of neutron capture rates on unstable neutron rich nuclei, which can have uncertainties of more than a factor 20 in the band of the i-process. We use a Monte Carlo variation of 52 neutron capture rates and a 1D multi-zone post-processing model for the i-process in Sakurai's object to determine the cumulative effect of these uncertainties on the final elemental abundance predictions. We find that the nuclear physics uncertainties are large and comparable to observational errors. Within these uncertainties the model predictions are consistent with observations. A correlation analysis of the results of our MC simulations reveals that the strongest impact on the predicted abundances of Rb, Sr, Y and Zr is made by the uncertainties in the (n, γ) reaction rates of 85Br, 86Br, 87Kr, 88Kr, 89Kr, 89Rb, 89Sr, and 92Sr. This conclusion is supported by a series of multi-zone simulations in which we increased and decreased to their maximum and minimum limits one or two reaction rates per run. We also show that simple and fast one-zone simulations should not be used instead of more realistic multi-zone stellar simulations for nuclear sensitivity and uncertainty studies of convective–reactive processes. Our findings apply more generally to any i-process site with similar neutron exposure, such as rapidly accreting white dwarfs with near-solar metallicities.

  3. A review of breast tomosynthesis. Part I. The image acquisition process

    Science.gov (United States)

    Sechopoulos, Ioannis

    2013-01-01

    Mammography is a very well-established imaging modality for the early detection and diagnosis of breast cancer. However, since the introduction of digital imaging to the realm of radiology, more advanced, and especially tomographic imaging methods have been made possible. One of these methods, breast tomosynthesis, has finally been introduced to the clinic for routine everyday use, with potential to in the future replace mammography for screening for breast cancer. In this two part paper, the extensive research performed during the development of breast tomosynthesis is reviewed, with a focus on the research addressing the medical physics aspects of this imaging modality. This first paper will review the research performed on the issues relevant to the image acquisition process, including system design, optimization of geometry and technique, x-ray scatter, and radiation dose. The companion to this paper will review all other aspects of breast tomosynthesis imaging, including the reconstruction process. PMID:23298126

  4. A computer based I and C to improve nuclear power plant operation and safety

    International Nuclear Information System (INIS)

    Appell, Bernard; Beltranda, Guy

    1995-01-01

    Chooz B1 is the head of 1400 MW N4 series (up to now, a programme of 4 identical units have been ordered) will be put on the French national grid this year (1995). Hot tests were performed last autumn. Loading fuel is scheduled in June 95. Chooz B2 will follow 6 months later. This nuclear power plant series is fully French designed. It comprises, compared to the former 1300 MW series, evolution concerning mainly the turbine, the steam generators, the primary pumps, the I and C and the man machine interface. A major improvement for the plant operation and safety is the computerised I and C which comprises the protection system (specific controllers), the process automation system (off the shelf equipment), the computer based and conventional man machine interfaces associated. These systems were put in service last year. This paper is focused on them. (author)

  5. Next Generation Thermal Management Materials: Boron Arsenide for Isotropic Diamond Like Thermal Conductivity - Affordable BAs Processing Innovations, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — The purpose of this SBIR phase I proposal is to design, develop and carry out the materials and process engineering studies to demonstrate the feasibility of...

  6. The business of iOS app development for iPhone, iPad and iPod Touch

    CERN Document Server

    Wooldridge, Dave

    2014-01-01

    Updated and expanded for the new Apple iOS8, The Business of iOS App Development, Third Edition shows you how to incorporate marketing and business savvy into every aspect of the design and development process, giving your app the best possible chance of succeeding in the App Store. This book is written by experienced developers with business backgrounds, taking you step-by-step through cost-effective marketing techniques that have proven successful for professional iOS app creators-perfect for independent developers on shoestring budgets. No prior business knowledge is required. The pheno

  7. Towards a theoretical framework for analysing organisational processes

    DEFF Research Database (Denmark)

    Rocha, Robson Silva

    2003-01-01

    In this paper, I discuss how a theoretical framework can be build to analyse socialprocesses of transformation, making the link between macro and micro processes, inwhich this dichotomy can be overcome. The aim of this theoretical framework is toaccount for the transformation in societal...... characteristics and changes in actors' strategiesat micro level, in a way that links macro changes and micro processes - the cognitivestructures of the individual and social structures of the society. In order to build this framework, I draw from the figuration sociology of Norbert Elias, the praxeologia of...

  8. Important to investigate the dynamics of the stigma process.

    Science.gov (United States)

    Angermeyer, Matthias

    2004-01-01

    Studies have shown that the stigma of the most common mental disorder, namely depression, expose people with these disorders to a substantial amount of stigmatization in the workplace. Apart from the descriptive assessment of the magnitude of stigma, it is also important to investigate the dynamics of the stigma process. Agreeing with Dr. Stuart, three approaches to research on stigma and the workplace are proposed. The first is the dimension of social stigma, i.e., knowledge, attitudes and practices of employers. The second is the perspectives of the patients, i.e., self- stigmatization. The third is legal and policy frameworks, i.e., structural discrimination.

  9. Dominance of <i>Saccharomyces cerevisiaei> in alcoholic fermentation processes

    DEFF Research Database (Denmark)

    Albergaria, Helena; Arneborg, Nils

    2016-01-01

    Winemaking, brewing and baking are some of the oldest biotechnological processes. In all of them, alcoholic fermentation is the main biotransformation and Saccharomyces cerevisiae the primary microorganism. Although a wide variety of microbial species may participate in alcoholic fermentation and...

  10. How to make your development process user centred

    CERN Multimedia

    CERN. Geneva

    2017-01-01

    I’ve been designing and managing the development processes of websites and applications for companies since the 90s. In those years I’ve seen a lot of projects fail. The biggest issue: development teams prefer to spend the majority of their time in their cave behind their screens and clients stay in their ivory tower. This means that software is developed based on assumptions and personal taste. I’ve been to way to many meetings where arguments were leverages with ‘I don’t like this’ or ‘I think the user doesn’t want this’. During this presentation I will show the steps that should be taken to avoid all these issues and make a product that does bring the business objectives and the user’s desires together and is optimised for the real end user thus creates a usable product.

  11. Economic impact associated with the decommissioning process of Vandellos I Nuclear Power Plant; Informe final. Impacto economico del desmantelamiento de la central nuclear Vandellos I

    Energy Technology Data Exchange (ETDEWEB)

    Rodriguez Silva, M.

    2005-07-01

    This economic study examines the economic impact associated with the decommissioning process of the Vandellos I Nuclear Power Plant, measured in terms of the global income that generated the ending of the Nuclear Power Plant activity, on the territory. To this end, we will take into account the total investment that has been necessary to complete the process of decommissioning. The economic impact is calculated using the Input- Output methodology. Briefly, the Input-Output model defines a group of accounting relationships that reflect the links taking place within the production system. The Input-Output model is based on the assumption that given an increase (decrease) in the final demand of one sector, this sector should produce more (less) to satisfy this new demand. At the same time, this will lead to demand more (less) intermediate consumption goods from the remainder sectors of the economy. Then, these sectors should produce more (less) and use more (less) intermediate inputs, and so on. Therefore, an increase (decrease) in the final demand of one sector multiplies the effect throughout the economy, following the interdependency relationships that exist among the productive activities. We will start by collecting an exhaustive economic information. This information covers the whole decommissioning process and the whole economic and productive activity of the province of Tarragona. Next, this information is used with the objective of building an Input-Output table of the province that will serve as a base to establish the global economic impact of Vandellos I. The incomes and employment generation has been evaluated in the province of Tarragona that, following the main assumptions, correspond to the global effects of the decommissioning. In addition, we have evaluated the income and employment generation within the region where the nuclear power plant is located. The total income impacts show a high multiplier effect due to the investment carried out during the

  12. Transforming Internal Activities of Business Process Models to Services Compositions

    NARCIS (Netherlands)

    Dirgahayu, Teduh; Quartel, Dick; van Sinderen, Marten J.; Mostefaoui, S.K.; Maamar, Z.; Ferreira Pires, L.; Hammoudi, S.; Rinderle-Ma, S.; Sadiq, S.; Schulz, K.

    As a service composition language, BPEL imposes as constraint that a business process model should consist only of activities for interacting with other business processes. BPEL provides limited support for implementing internal activities, i.e. activities that are performed by a single business

  13. "I Got My Diagnosis on a Yellow Post-it Note": Young Adult Cancer Patients' Experiences of the Process of Being Diagnosed With Cancer.

    Science.gov (United States)

    Hauken, May Aasebø; Hølge-Hazelton, Bibbi; Larsen, Torill M B

    2018-06-01

    Cancer in young adults is rare but young adult cancer patients (YACPs) are at an increased risk of severe physical and psychosocial impairments during cancer treatment and survivorship. However, little is known about the onset of this process. The aim of this study was to explore how young cancer survivors experience the process of being diagnosed with cancer. A qualitative method founded on a phenomenological-hermeneutical approach was used and included in-depth interviews with 20 young adult survivors (aged 24-35 years) with different cancer diagnoses, analyzed by Systematic Text Condensation. The participants' experiences of the diagnosis process were elaborated according to 3 main themes: (1) "I felt something was wrong, but…," (2) "The traumatic uncertainty," and (3) "The day my world collapsed." The findings indicate that the YACPs experienced a diagnosis of cancer as a highly traumatic and long-lasting process, characterized by lack of information and uncertainty. The findings indicate that healthcare professionals do not acknowledge the vulnerable phase of life and transitional challenges of YACPs. The findings highlight the need to raise awareness of cancer in young adulthood in the public and in the primary healthcare system, to shorten the diagnosis process, and to clarify responsibility for age-related information and psychosocial follow-up during the diagnosis process. Further research is highly warranted.

  14. Synthesis and processing of escherichia-coli tem-beta-lactamase and bacillus-licheniformis alpha-amylase in escherichia-coli : The role of signal peptidase-i

    NARCIS (Netherlands)

    van Dijl, J M; Smith, H; Bron, Sierd; Venema, Gerard

    A mutant of Escherichia coli, in which signal peptidase I synthesis can be regulated, was constructed. The mutant was used to study the effects of signal peptidase I limitation on the synthesis and efficiency of processing of two proteins: the periplasmic E. coli TEM-beta-lactamase and Bacillus

  15. SYNTHESIS AND PROCESSING OF ESCHERICHIA-COLI TEM-BETA-LACTAMASE AND BACILLUS-LICHENIFORMIS ALPHA-AMYLASE IN ESCHERICHIA-COLI : THE ROLE OF SIGNAL PEPTIDASE-I

    NARCIS (Netherlands)

    van Dijl, J M; SMITH, H; BRON, S; VENEMA, G

    A mutant of Escherichia coli, in which signal peptidase I synthesis can be regulated, was constructed. The mutant was used to study the effects of signal peptidase I limitation on the synthesis and efficiency of processing of two proteins: the periplasmic E. coli TEM-beta-lactamase and Bacillus

  16. Silver(I) and copper(I) complexes with the closo-decaborate anion B10H102- as a ligand

    International Nuclear Information System (INIS)

    Malinina, E.A.; Zhizhin, K.Yu.; Polyakova, I.N.; Lisovskij, M.V.; Kuznetsov, N.T.

    2002-01-01

    Studying the process of silver(I) and copper(I) complexing with closo-borate anion B 10 H 10 2- it is determined that the last can to play a role of intraspherical ligand forming stable coordination compounds of two types: Cat[MB 10 H 10 ] and [M 2 B 10 H 10 ] (M=Ag(I), Cu(I)). In these compounds the bond metal-boron skeleton is realized by means of formation of three-center bonds M-H-B. Structure of the complexes Cs[AgB 10 H 10 ] and [(C 2 H 5 ) 3 NH][AgB 10 H 10 ] and possible mechanism of their formation are discussed [ru

  17. Reenginering of the i4 workflow engine

    OpenAIRE

    Likar, Tilen

    2013-01-01

    I4 is an enterprise resource planning system which allows you to manage business processes. Due to increasing demands for managing complex processes and adjusting those processes to global standards, a renewal of a part of the system was required. In this thesis we faced the reengineering of the workflow engine, and corresponding data model. We designed a business process diagram in Bizagi Porcess Modeler. The import to i4 and the export from i4 was developed on XPDL file exported from the mo...

  18. Nature of radiative recombination processes in layered semiconductor PbCdI{sub 2} nanostructural scintillation material

    Energy Technology Data Exchange (ETDEWEB)

    Bukivskii, A.P. [Institute of Physics of the National Academy of Sciences of Ukraine, 03028 Kyiv (Ukraine); Gnatenko, Yu.P., E-mail: yuriygnatenko@ukr.net [Institute of Physics of the National Academy of Sciences of Ukraine, 03028 Kyiv (Ukraine); Piryatinskii, Yu.P. [Institute of Physics of the National Academy of Sciences of Ukraine, 03028 Kyiv (Ukraine); Gamernyk, R.V. [Lviv National University, 8 Kyryl o and Mefodiy Str., 29005 Lviv (Ukraine)

    2017-05-15

    We report on the efficient photoluminescence (PL) and radioluminescence (RL) of the PbI{sub 2} nanoclusters (NCLs), which are naturally formed in the nanostructured Pb{sub 1-X}Cd{sub x}I{sub 2} alloys (X=0.70). Here, we carried out the studies of the nature of radiative recombination processes in the NCLs of various sizes by measuring PL temperature evolution. Our results indicate that at low temperatures the PL is mainly caused by exciton emission and recombination of donor-acceptor pairs, generated in volume of large NCLs. The broad bands, which are associated with the deep intrinsic surface states, including self-trapped excitons (STEs), are dominant in the PL spectra at higher temperature (>100 K). Our work shows that the nature of emission, associated with RL bands is analogous to that for PL bands. It was shown that the investigated nanostructured material is strongly radiation-resistant. Thus, the Pb{sub 1-X}Cd{sub X}I{sub 2} alloys can be considered as new effective layered semiconductor nanostructured materials which can be suitable for the elaboration of perspective semiconductor scintillators. These nanomaterials have promising prospects for applications in new generations of devices for biomedical diagnostics and industrial imaging applications. - Highlights: •The intense PL and RL of nanostructural PbCdI{sub 2} alloys were observed. •The nature of recombination processes of the nanoscintillators was established. •The low temperature PL is caused by exciton and donor-acceptor pairs recombination. •The broad PL bands are due to the deep intrinsic states formed on the NCLs surface. •The PL associated with STEs for NCLs of different sizes was analyzed in detail. •It was shown that the nature of PL and RL spectra is same.

  19. Luminescent zinc(ii) and copper(i) complexes for high-performance solution-processed monochromic and white organic light-emitting devices.

    Science.gov (United States)

    Cheng, Gang; So, Gary Kwok-Ming; To, Wai-Pong; Chen, Yong; Kwok, Chi-Chung; Ma, Chensheng; Guan, Xiangguo; Chang, Xiaoyong; Kwok, Wai-Ming; Che, Chi-Ming

    2015-08-01

    The synthesis and spectroscopic properties of luminescent tetranuclear zinc(ii) complexes of substituted 7-azaindoles and a series of luminescent copper(i) complexes containing 7,8-bis(diphenylphosphino)-7,8-dicarba- nido -undecaborate ligand are described. These complexes are stable towards air and moisture. Thin film samples of the luminescent copper(i) complexes in 2,6-dicarbazolo-1,5-pyridine and zinc(ii) complexes in poly(methyl methacrylate) showed emission quantum yields of up to 0.60 (for Cu-3 ) and 0.96 (for Zn-1 ), respectively. Their photophysical properties were examined by ultrafast time-resolved emission spectroscopy, temperature dependent emission lifetime measurements and density functional theory calculations. Monochromic blue and orange solution-processed OLEDs with these Zn(ii) and Cu(i) complexes as light-emitting dopants have been fabricated, respectively. Maximum external quantum efficiency (EQE) of 5.55% and Commission Internationale de l'Eclairage (CIE) coordinates of (0.16, 0.19) were accomplished with the optimized Zn-1 -OLED while these values were, respectively 15.64% and (0.48, 0.51) for the optimized Cu-3 -OLED. Solution-processed white OLEDs having maximum EQE of 6.88%, CIE coordinates of (0.42, 0.44), and colour rendering index of 81 were fabricated by using these luminescent Zn(ii) and Cu(i) complexes as blue and orange light-emitting dopant materials, respectively.

  20. Stellar oxygen abundances. I - A resolution to the 7774 A O I abundance discrepancy

    Science.gov (United States)

    King, Jeremy R.

    1993-09-01

    We investigate the discrepancy between O/Fe abundance ratios of metal-poor stars derived from the 7774 A O I triplet and O/Fe ratios determined from other oxygen lines. We propose a possible resolution to this discrepancy which also eliminates the correlation of O/Fe and T(eff) found in a recent 7774 A O I analysis. The equivalent widths of Abia & Rebolo (1989) are found to be systematically too high by 25 percent. Arguments are presented that current temperature estimates for halo stars are 150-200 K too low. Using the guidance of both model atmospheres and other empirical color-T(eff) relations, we construct new color temperature relations for metal-poor stars. These relations are tied to the temperature scale of Saxner & Hammarback (1985) for metal-rich stars. We use (b-y) and (V-K) indices to redetermine values of T(eff) for a handful of halo stars. (B-V)-T(eff) relations which do not take into account the effects of metallicity are found to be inadequate. Revised O/Fe ratios are determined using the new temperature scale. The mean abundance ratio of the reanalyzed halo dwarfs is about +0.52. There is no trend of O/Fe with Fe/H or T(eff).

  1. A universal route to fabricate n-i-p multi-junction polymer solar cells via solution processing

    NARCIS (Netherlands)

    Rasi, Dario Di Carlo; Hendriks, Koen H.; Heintges, Gael H. L.; Simone, Giulio; Gelinck, Gerwin H.; Gevaerts, Veronique S.; Andriessen, Ronn; Pirotte, Geert; Maes, Wouter; Li, Weiwei; Wienk, Martijn M.; Janssen, Rene A. J.

    The interconnection layer (ICL) that connects adjacent subcells electrically and optically in solution‐processed multi‐junction polymer solar cells must meet functional requirements in terms of work functions, conductivity, and transparency, but also be compatible with the multiple layer stack in

  2. Glutathiolactaldehyde as a probe of the overall stereochemical course of glyoxalase-I catalyzed reactions

    International Nuclear Information System (INIS)

    Brush, E.J.; Kozarich, J.W.

    1986-01-01

    The overall stereochemical course of the reactions catalyzed by glyoxalase-I (GX-I) has remained elusive as the substrates are equilibrium mixtures of rapidly interconverting diastereomeric thiohemiacetals. However, with the discovery of inverse substrate processing by Kozarich and coworkers, it is possible to design GX-I substrate analogs that are intrinsically more stable than the thiohemiacetals. Hence, Chari and Kozarich reported that glutathiohydroxyacetone (GHA, GSCH 2 COCH 2 OH) undergoes GX-I catalyzed exchange of the pro-S hydroxymethyl proton with solvent deuterium. Their data suggest that GX-I processes a single diastereomeric thiohemiacetal, and are consistent with a cis-enediol intermediate. To test this hypothesis and to follow the overall stereochemistry on a single substrate, they have prepared glutathiolactaldehyde (GLA, GSCH 2 CHOHCHO) as a potential inverse substrate. Human erythrocyte GX-I catalyzes the isomerization of GLA to GHA as evidenced by UV and NMR spectra of the product. Solvent deuterium is incorporated into the hydroxymethyl position, and NMR data suggest that incorporation is stereospecific. Furthermore, 50% of the expected amount of GHA is produced indicating that only one diastereomer of GLA is processed by GX-I. Identification of the absolute stereochemistry of the substrate diastereomer will lead to a clarification of the overall stereochemical and mechanistic course of GX-I catalyzed reactions

  3. Cas5d Protein Processes Pre-crRNA and Assembles into a Cascade-like Interference Complex in Subtype I-C/Dvulg CRISPR-Cas System

    Energy Technology Data Exchange (ETDEWEB)

    Nam, Ki Hyun; Haitjema, Charles; Liu, Xueqi; Ding, Fran; Wang, Hongwei; DeLisa, Matthew P.; Ke, Ailong (Yale); (Cornell); (Tsinghua)

    2012-10-10

    Clustered regularly interspaced short palindromic repeats (CRISPRs), together with an operon of CRISPR-associated (Cas) proteins, form an RNA-based prokaryotic immune system against exogenous genetic elements. Cas5 family proteins are found in several type I CRISPR-Cas systems. Here, we report the molecular function of subtype I-C/Dvulg Cas5d from Bacillus halodurans. We show that Cas5d cleaves pre-crRNA into unit length by recognizing both the hairpin structure and the 3 single stranded sequence in the CRISPR repeat region. Cas5d structure reveals a ferredoxin domain-based architecture and a catalytic triad formed by Y46, K116, and H117 residues. We further show that after pre-crRNA processing, Cas5d assembles with crRNA, Csd1, and Csd2 proteins to form a multi-sub-unit interference complex similar to Escherichia coli Cascade (CRISPR-associated complex for antiviral defense) in architecture. Our results suggest that formation of a crRNA-presenting Cascade-like complex is likely a common theme among type I CRISPR subtypes.

  4. Efficient organic solar cells using copper(I) iodide (CuI) hole transport layers

    Energy Technology Data Exchange (ETDEWEB)

    Peng, Ying [Key Laboratory of Luminescence and Optical Information, Ministry of Education, Institute of Optoelectronic Technology, Beijing Jiaotong University, Beijing 100044 (China); Department of Physics and Centre for Plastic Electronics, Blackett Laboratory, Imperial College London, London SW7 2AZ (United Kingdom); Yaacobi-Gross, Nir; Perumal, Ajay K.; Faber, Hendrik A.; Bradley, Donal D. C.; Anthopoulos, Thomas D., E-mail: zhqhe@bjtu.edu.cn, E-mail: t.anthopoulos@imperial.ac.uk [Department of Physics and Centre for Plastic Electronics, Blackett Laboratory, Imperial College London, London SW7 2AZ (United Kingdom); Vourlias, George; Patsalas, Panos A. [Department of Physics, Laboratory of Applied Physics, Aristotle University of Thessaloniki, GR-54124 Thessaloniki (Greece); He, Zhiqun, E-mail: zhqhe@bjtu.edu.cn, E-mail: t.anthopoulos@imperial.ac.uk [Key Laboratory of Luminescence and Optical Information, Ministry of Education, Institute of Optoelectronic Technology, Beijing Jiaotong University, Beijing 100044 (China)

    2015-06-15

    We report the fabrication of high power conversion efficiency (PCE) polymer/fullerene bulk heterojunction (BHJ) photovoltaic cells using solution-processed Copper (I) Iodide (CuI) as hole transport layer (HTL). Our devices exhibit a PCE value of ∼5.5% which is equivalent to that obtained for control devices based on the commonly used conductive polymer poly(3,4-ethylenedioxythiophene): polystyrenesulfonate as HTL. Inverted cells with PCE >3% were also demonstrated using solution-processed metal oxide electron transport layers, with a CuI HTL evaporated on top of the BHJ. The high optical transparency and suitable energetics of CuI make it attractive for application in a range of inexpensive large-area optoelectronic devices.

  5. Efficient organic solar cells using copper(I) iodide (CuI) hole transport layers

    International Nuclear Information System (INIS)

    Peng, Ying; Yaacobi-Gross, Nir; Perumal, Ajay K.; Faber, Hendrik A.; Bradley, Donal D. C.; Anthopoulos, Thomas D.; Vourlias, George; Patsalas, Panos A.; He, Zhiqun

    2015-01-01

    We report the fabrication of high power conversion efficiency (PCE) polymer/fullerene bulk heterojunction (BHJ) photovoltaic cells using solution-processed Copper (I) Iodide (CuI) as hole transport layer (HTL). Our devices exhibit a PCE value of ∼5.5% which is equivalent to that obtained for control devices based on the commonly used conductive polymer poly(3,4-ethylenedioxythiophene): polystyrenesulfonate as HTL. Inverted cells with PCE >3% were also demonstrated using solution-processed metal oxide electron transport layers, with a CuI HTL evaporated on top of the BHJ. The high optical transparency and suitable energetics of CuI make it attractive for application in a range of inexpensive large-area optoelectronic devices

  6. "Borges and I," A Narrative Sleight of Hand

    Directory of Open Access Journals (Sweden)

    Armando F. Zubizarreta

    1998-06-01

    Full Text Available Because of its autobiographical appearance, critics have paid little attention to the narrative of "Borges and I" which is so masterfully handled that its complex and transparent texture is almost invisible. A close analysis shows, however, that, in the confessional mode, the two individuals—I and Borges—are true characters involved in a narrative action that is taking place to allow the implementation of vengeance. By focusing on his victim's experience, the narrating I offers an attractive bait to his victimizer, Borges. Borges, the writer, driven by a compulsive pattern of stealing, unsuspectingly takes over the victim's grievances against him by virtue of his own writing. To unveil those basic elements of narrative at play in this short story, the participation of an active reader, as witness to the process and as recipient of the indicting text, is actually demanded. Thus, "Borges and I" may be considered a superb example of Jorge Luis Borges's art.

  7. Stereodynamics: From elementary processes to macroscopic chemical reactions

    Energy Technology Data Exchange (ETDEWEB)

    Kasai, Toshio [Department of Chemistry, National Taiwan University, Taipei 106, Taiwan (China); Graduate School of Science, Department of Chemistry, Osaka University, Toyonaka, 560-0043 Osaka (Japan); Che, Dock-Chil [Graduate School of Science, Department of Chemistry, Osaka University, Toyonaka, 560-0043 Osaka (Japan); Tsai, Po-Yu [Department of Chemistry, National Taiwan University, Taipei 106, Taiwan (China); Department of Chemistry, National Chung Hsing University, Taichung 402, Taiwan (China); Institute of Atomic and Molecular Sciences, Academia Sinica, Taipei 106, Taiwan (China); Lin, King-Chuen [Department of Chemistry, National Taiwan University, Taipei 106, Taiwan (China); Institute of Atomic and Molecular Sciences, Academia Sinica, Taipei 106, Taiwan (China); Palazzetti, Federico [Scuola Normale Superiore, Pisa (Italy); Dipartimento di Chimica Biologia e Biotecnologie, Università di Perugia, 06123 Perugia (Italy); Aquilanti, Vincenzo [Dipartimento di Chimica Biologia e Biotecnologie, Università di Perugia, 06123 Perugia (Italy); Istituto di Struttura della Materia, Consiglio Nazionale delle Ricerche, Roma (Italy); Instituto de Fisica, Universidade Federal da Bahia, Salvador (Brazil)

    2015-12-31

    This paper aims at discussing new facets on stereodynamical behaviors in chemical reactions, i.e. the effects of molecular orientation and alignment on reactive processes. Further topics on macroscopic processes involving deviations from Arrhenius behavior in the temperature dependence of chemical reactions and chirality effects in collisions are also discussed.

  8. Networking and Information Technology Research and Development Program. Supplement to the President’s Budget for Fiscal Year 2011

    Science.gov (United States)

    2010-02-01

    NNSA, EPA Exascale computing: International Exascale Software Project (IESP) – NSF, DOE/SC, DOE/NNSA Multiscale modeling in biomedical, biological...computer science and applied mathematics foundations to address computation at the petascale level and beyond, to exascale New hardware and software...control theory, risk assessment) – NSF, DOE/SC, DARPA, DOE/NNSA Pathways to exascale computing: Interconnect and memory technologies; participation in

  9. Characterization of microcrystalline I-layer for solar cells prepared in low temperature - plastic compatible process

    KAUST Repository

    Sliz, Rafal

    2012-06-01

    Microcrystalline silicon (mc-Si) lms deposited using a Plasma Enhanced Chemical Vapour Deposition (PECVD) process constitute an important material for manufacturing low-cost, large-area thin-lm devices, such as solar cells or thin-lm transistors. Although the deposition of electronic-grade mc-Si using the PECVD process is now well established, the high substrate temperature required (~400°C) does not lend itself to electronic devices with exible form factors fabricated on low-cost plastic substrates. In this study, we rst investigated an intrinsic mc-Si layer deposited at plastic-compatible substrate temperatures (~150°C) by characterising the properties of the lm and then evaluated its applicability to p-i-n solar cells though device characterisation. When the performance of the solar cell was correlated with lm properties, it was found that, although it compared unfavourably with mc-Si deposited at higher temperatures, it remained a very promising option. Nonetheless, further development is required to increase the overall eciency of mc-Si exible solar cells.

  10. Recommendations for the measurement 131I in human thyroid using a detector of NaI(Tl)

    International Nuclear Information System (INIS)

    Puerta Yepes, N.; Rojo, A.M.; Andres, P.A.

    2010-01-01

    The Argentine Total Body Counter Laboratory of the Nuclear Regulatory Authority participated in the last regional intercomparison Exercise organized in the frame of the IAEA Project RLA 9/066 related with in vivo measurements of 131 I in the thyroid. There were identified some difficulties in determining the efficiency and calibration factor (CF) for the 131 I when a source of 133 Ba and a detector of NaI (Tl) are used in the calibration process. Independent measurements were performed for two calibration sources of known activity ( 133 Ba and 131 I) with identical geometry pattern and using a gamma spectrometry system with NaI(Ti) detector. It was found that the region of interest (ROI) which, both in the spectrum of 133 Ba as in the spectrum of 131 I, had the same efficiency. It was determined the activity of the source of 133 Ba , distributed in the intercomparison, and the calibrated source of 131 I using different values of efficiency and FC obtained. It was analyzed the conditions under which the use of 133 Ba as a source of calibration is effective for the measurement of 131 I. (authors) [es

  11. Review of defense display research programs

    Science.gov (United States)

    Tulis, Robert W.; Hopper, Darrel G.; Morton, David C.; Shashidhar, Ranganathan

    2001-09-01

    Display research has comprised a substantial portion of the defense investment in new technology for national security for the past 13 years. These investments have been made by the separate service departments and, especially, via several Defense Research Projects Agency (DARPA) programs, known collectively as the High Definition Systems (HDS) Program (which ended in 2001) and via the Office of the Secretary of Defense (OSD) Defense Production Act (DPA) Title III Program (efforts ended in 2000). Using input from the Army, Navy, and Air Force to focus research and identify insertion opportunities, DARPA and the Title III Program Office have made investments to develop the national technology base and manufacturing infrastructure necessary to meet the twin challenge of providing affordable displays in current systems and enabling the DoD strategy of winning future conflicts by getting more information to all participants during the battle. These completed DARPA and DPA research and infrastructure programs are reviewed. Service investments have been and are being made to transition display technology; examples are described. Display science and technology (S&T) visions are documented for each service to assist the identification of areas meriting consideration for future defense research.

  12. R and D thermochemical I-S process at JAERI

    International Nuclear Information System (INIS)

    Onuki, K.; Kubo, S.; Nakajima, H.; Higashi, S.; Kasahara, S.; Ishiyama, S.; Okuda, H.

    2004-01-01

    The Japan Atomic Energy Research Institute (JAERI) has conducted a study on the thermochemical water-splitting process of the iodine-sulfur family (IS process). In the IS process, water will react with iodine and sulfur dioxide to produce hydrogen iodide and sulfuric acid, which are then decomposed thermally to produce hydrogen and oxygen. High temperature nuclear heat, mainly supplied by a High Temperature Gas-cooled Reactor (HTGR), is used to drive the endothermic decomposition of sulfuric acid. JAERI has demonstrated the feasibility of the water-splitting hydrogen production process by carrying out laboratory-scale experiments in which combined operation of fundamental reactions and separations using the IS process was performed continuously. At present, the hydrogen production test is continuing, using a scaled-up glass apparatus. Corrosion-resistant materials for constructing a large-scale plant and process improvements by introducing advanced separation techniques, such as membrane separation, are under study. Future R and D items are discussed based on the present activities. (author)

  13. Torrefaction Processing of Human Fecal Waste, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — New technology is needed to collect, stabilize, safen, recover useful materials, and store human fecal waste for long duration missions. The current SBIR Phase I...

  14. The determination and monitoring of 131I activity in sewage treatment plants based on A2/O processes

    International Nuclear Information System (INIS)

    Jimenez, Fernando; Lopez, Raul; Pardo, Rafael; Deban, Luis; Garcia-Talavera, Marta

    2011-01-01

    131 I, a radionuclide used in nuclear medicine facilities, is habitually dumped into domestic sewer systems, which causes its control in municipal sewage treatment plants (STP) to become necessary. In this paper, we describe a procedure for the determination of the 131 I activity based on its precipitation as silver (I) iodide, its dissolution with cyanide in ammonia medium and its measurement by the liquid scintillation counting technique (LSC). After optimization, this LSC procedure allows the determination of 131 I activities with a limit of detection (CCβ) of 11 mBq kg -1 . The procedure was successfully validated by comparison with the normative and requires both less sample volume and measurement time than the standard procedure. The method has been applied to the monitoring of 131 I in the STP of Valladolid (Spain), which found activities below the maximum allowed by legislation and showed a near constant background 131 I activity in the influents with punctual increases corresponding to authorized spills. The mean 131 I removing efficiency of the STP was 52%.

  15. CYP2E1 Rsa I/Pst I polymorphism contributes to oral cancer susceptibility: a meta-analysis.

    Science.gov (United States)

    Niu, Yuming; Hu, Yuanyuan; Wu, Mingyue; Jiang, Fei; Shen, Ming; Tang, Chunbo; Chen, Ning

    2012-01-01

    Previous data on association between CYP2E1 Rsa I/Pst I polymorphism and oral cancer risk were controversial. To investigate the association between CYP2E1 Rsa I/Pst I polymorphism and oral cancer risk. We performed a meta-analysis to assess the relationship between oral cancer and genotype with English language until June 2010. Twelve published case-control studies of 1259 patients with oral cancer and 2262 controls were acquired. Odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of the association in codominant and dominant models. Overall, the pooled ORs indicated a significant association between CYP2E1 Rsa I/Pst I polymorphism and oral cancer risk (for c1/c2 vs. c1/c1: OR=1.30, 95% CI=1.04-1.62, Pheterogeneity=0.57; for (c1/c2+c2/c2) vs. c1/c1: OR=1.32, 95% CI=1.07-1.64, Pheterogeneity=0.57, respectively). In subgroup analysis by race, the same significant risks were found among Asian (for c1/c2 vs. c1/c1: OR=1.41, 95% CI=1.05-1.91, Pheterogeneity=0.92; for (c1/c2+c2/c2) vs. c1/c1: OR=1.43, 95% CI=1.08-1.88, Pheterogeneity=0.97, respectively). In conclusion, this meta-analysis demonstrates that CYP2E1 Rsa I/Pst I c2 allele may be a biomarker for oral cancer, especially among Asian populations.

  16. Summary of current radiation dose estimates to humans from 123I, 124I, 126I, 130I, and 131I as sodium rose bengal

    International Nuclear Information System (INIS)

    Anon.

    1975-01-01

    Estimated absorbed doses to human gall bladder, gastrointestinal tract, liver, ovaries, bone marrow, and testes from 123 I, 124 I, 126 I, 130 I, and 131 I after a single intravenous administration as sodium rose bengal are summarized. The greatest uncertainty in these dose estimates is due to the variability in time for the movement of radioiodine through the biliary tract, gall bladder, and gastrointestinal tract

  17. I am quitting my job. Specialist nurses in perioperative context and their experiences of the process and reasons to quit their job.

    Science.gov (United States)

    Lögde, Ann; Rudolfsson, Gudrun; Broberg, Roma Runesson; Rask-Andersen, Anna; Wålinder, Robert; Arakelian, Erebouni

    2018-05-01

    The lack of specialist nurses in operating theatres is a serious problem. The aim of this study was to describe reasons why specialist nurses in perioperative care chose to leave their workplaces and to describe the process from the thought to the decision. Twenty specialist nurses (i.e. anaesthesia, NA, and operating room nurses) from seven university- and county hospitals in Sweden participated in qualitative individual in-depth interviews. Data were analysed by systematic text condensation. We identified four themes of reasons why specialist nurses quitted their jobs: the head nurses' betrayal and dismissive attitude, and not feeling needed; inhumane working conditions leading to the negative health effects; not being free to decide about one's life and family life being more important than work; and, colleagues' diminishing behaviour. Leaving one's job was described as a process and specialist nurses had thought about it for some time. Two main reasons were described; the head nurse manager's dismissive attitude and treatment of their employees and colleagues' mistreatment and colleagues' diminishing behaviour. Increasing knowledge on the role of the head nurse managers in specialist nurses' decision making for leaving their workplace, and creating a friendly, non-violent workplace, may give the opportunity for them to take action before it is too late.

  18. Crowd Sourced Formal Verification-Augmentation (CSFV-A)

    Science.gov (United States)

    2016-06-01

    Projects Agency (DARPA), Air Force Research Laboratory (AFRL), Charles River Analytics Inc., and TopCoder, Inc. will be holding a contest to reward...CROWD SOURCED FORMAL VERIFICATION – AUGMENTATION (CSFV-A) CHARLES RIVER ANALYTICS, INC. JUNE 2016 FINAL TECHNICAL REPORT APPROVED FOR PUBLIC...CSFV 5e. TASK NUMBER TC 5f. WORK UNIT NUMBER RA 7. PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) Charles River Analytics, Inc. 625 Mount Auburn

  19. Development of a Multipurpose Extruder/Press Food Processing System, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Insta-Pro International, proposes the design and development of a versatile, compact, lightweight, energy efficient, and easy maintained seed processing equipment...

  20. 32 CFR 37.675 - Must I report when I enter into a TIA allowing a for-profit firm to use an IPA?

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 1 2010-07-01 2010-07-01 false Must I report when I enter into a TIA allowing a for-profit firm to use an IPA? 37.675 Section 37.675 National Defense Department of Defense OFFICE OF... Must I report when I enter into a TIA allowing a for-profit firm to use an IPA? Yes, you must include...

  1. The effects of synthesis parameters on the formation of PbI2 particles under DTAB-assisted hydrothermal process

    International Nuclear Information System (INIS)

    Zhu Gangqiang; Hojamberdiev, Mirabbos; Liu Peng; Peng Jianhong; Zhou Jianping; Bian Xiaobin; Huang Xijin

    2011-01-01

    Highlights: ► Submicron- and micron-sized PbI 2 particles were hydrothermally synthesized. ► Structural transformation form belt-like to rod- and microtube-like was observed. ► Phase-pure PbI 2 particles could be hydrothermally obtained at pH 2 particles. ► The optical band gap energy of PbI 2 was slightly affected by morphology. - Abstract: Submicron- and micron-sized lead iodide (PbI 2 ) particles with well-controlled morphologies were successfully fabricated via a low-temperature hydrothermal process assisted by dodecyltrimethylammonium bromide (DTAB) as cationic surfactant. The as-synthesized powders were characterized by X-ray diffraction, scanning electron microscopy, transmission electron microscopy, and UV–vis spectroscopy. The effects of synthesis parameters (temperature, time, pH, and surfactant amount) were systematically investigated. The obtained results showed that the submicron structure was belt-like at 100–120 °C, transformed to rod-like by increasing temperature to 140 °C and it became a microtube-like at 160–200 °C. By changing the pH of the synthesizing solution, it was found that a pure PbI 2 phase could be obtained below 7. With the addition of increasing amount of surfactant, microparticles were converted to microrods → submicron belts → microtubes. The time-dependent experimental results revealed that the dissolution–recrystallization and dissolution–recrystallization–self-oriented-attachment were considered to be the possible mechanisms for the formation of the belt- and tube-like PbI 2 submicron- and micron-sized particles, respectively. The optical properties of the PbI 2 particles synthesized at 100–200 °C for 8 h under hydrothermal conditions were also studied.

  2. 31 CFR 363.96 - What do I need to know if I initially purchase a bond as a gift?

    Science.gov (United States)

    2010-07-01

    ... purchase a bond as a gift? 363.96 Section 363.96 Money and Finance: Treasury Regulations Relating to Money...Direct Gifts § 363.96 What do I need to know if I initially purchase a bond as a gift? (a) An entity may not purchase a gift savings bond. (b) The gift bond will be registered in the name of the recipient(s...

  3. 31 CFR 363.97 - What do I need to know if I transfer a book-entry savings bond to another person as a gift?

    Science.gov (United States)

    2010-07-01

    ... Bonds Purchased Through TreasuryDirect Gifts § 363.97 What do I need to know if I transfer a book-entry savings bond to another person as a gift? (a) You must certify online that the transfer is a gift. (b) You... a book-entry savings bond to another person as a gift? 363.97 Section 363.97 Money and Finance...

  4. I/O in the ATLAS multithreaded framework

    CERN Document Server

    Cranshaw, Jack; The ATLAS collaboration; Nowak, Marcin

    2018-01-01

    Scalable multithreading poses challenges to I/O, and the performance of a thread-safe I/O strategy may depend upon many factors, including I/O latencies, whether tasks are CPU- or I/O-intensive, and thread count. In a multithreaded framework, an I/O infrastructure must efficiently supply event data to and collect it from many threads processing multiple events in flight. In particular, on-demand reading from multiple threads may challenge caching strategies that were developed for serial processing and may need to be enhanced. This I/O infrastructure must also address how to read, make available, and propagate in-file metadata and other non-event data needed as context for event processing. We describe the design and scheduling of I/O components in the ATLAS multithreaded control framework, AthenaMT, for both event and non-event I/O. We discuss issues associated with exploiting the multithreading capabilities of our underlying persistence technology, ROOT, in a manner harmonious with the ATLAS framework’s o...

  5. Application of Special Cause Control Charts to Green Sand Process

    Directory of Open Access Journals (Sweden)

    Perzyk M.

    2015-12-01

    Full Text Available Statistical Process Control (SPC based on the well known Shewhart control charts, is widely used in contemporary manufacturing industry, including many foundries. However, the classic SPC methods require that the measured quantities, e.g. process or product parameters, are not auto-correlated, i.e. their current values do not depend on the preceding ones. For the processes which do not obey this assumption the Special Cause Control (SCC charts were proposed, utilizing the residual data obtained from the time-series analysis. In the present paper the results of application of SCC charts to a green sand processing system are presented. The tests, made on real industrial data collected in a big iron foundry, were aimed at the comparison of occurrences of out-of-control signals detected in the original data with those appeared in the residual data. It was found that application of the SCC charts reduces numbers of the signals in almost all cases It is concluded that it can be helpful in avoiding false signals, i.e. resulting from predictable factors.

  6. Health physics aspects of processing EBR-I coolant

    International Nuclear Information System (INIS)

    Burke, L.L.; Thalgott, J.O.; Poston, J.W. Jr.

    1998-01-01

    The sodium-potassium reactor coolant removed from the Experimental Breeder Reactor Number One after a partial reactor core meltdown had been stored at the Idaho National Engineering and Environmental Laboratory for 40 years. The State of Idaho considered this waste the most hazardous waste stored in the state and required its processing. The reactor coolant was processed in three phases. The first phase converted the alkali metal into a liquid sodium-potassium hydroxide. The second phase converted this caustic to a liquid sodium-potassium carbonate. The third phase solidified the sodium-potassium carbonate into a form acceptable for land disposal. Health physics aspects and dose received during each phase of the processing are discussed

  7. Microbial ecology to manage processes in environmental biotechnology.

    Science.gov (United States)

    Rittmann, Bruce E

    2006-06-01

    Microbial ecology and environmental biotechnology are inherently tied to each other. The concepts and tools of microbial ecology are the basis for managing processes in environmental biotechnology; and these processes provide interesting ecosystems to advance the concepts and tools of microbial ecology. Revolutionary advancements in molecular tools to understand the structure and function of microbial communities are bolstering the power of microbial ecology. A push from advances in modern materials along with a pull from a societal need to become more sustainable is enabling environmental biotechnology to create novel processes. How do these two fields work together? Five principles illuminate the way: (i) aim for big benefits; (ii) develop and apply more powerful tools to understand microbial communities; (iii) follow the electrons; (iv) retain slow-growing biomass; and (v) integrate, integrate, integrate.

  8. Multiresolution approach to processing images for different applications interaction of lower processing with higher vision

    CERN Document Server

    Vujović, Igor

    2015-01-01

    This book presents theoretical and practical aspects of the interaction between low and high level image processing. Multiresolution analysis owes its popularity mostly to wavelets and is widely used in a variety of applications. Low level image processing is important for the performance of many high level applications. The book includes examples from different research fields, i.e. video surveillance; biomedical applications (EMG and X-ray); improved communication, namely teleoperation, telemedicine, animation, augmented/virtual reality and robot vision; monitoring of the condition of ship systems and image quality control.

  9. An invertebrate embryologist's guide to routine processing of confocal images.

    Science.gov (United States)

    von Dassow, George

    2014-01-01

    It is almost impossible to use a confocal microscope without encountering the need to transform the raw data through image processing. Adherence to a set of straightforward guidelines will help ensure that image manipulations are both credible and repeatable. Meanwhile, attention to optimal data collection parameters will greatly simplify image processing, not only for convenience but for quality and credibility as well. Here I describe how to conduct routine confocal image processing tasks, including creating 3D animations or stereo images, false coloring or merging channels, background suppression, and compressing movie files for display.

  10. I and C success in Korea past and present projects and a view to the future

    International Nuclear Information System (INIS)

    Ridolfo, Charles F.

    2009-01-01

    Westinghouse Electric Company, LLC (WEC) has been providing advanced Instrumentation and Control (I and C) technology for the C E System 80, Korean Standard Nuclear Power Plant (KSNP), since the early 1990's. I and C equipment and technical support has been provided for a progression of these plants including Yonggwang Units 3,4,5,6, Ulchin Units 3,4,5,6, Shin Kori Units 1 and 2, Shin Wolsong Units 1 and 2, and most recently for Shin Kori Units 3 and 4. These I and C programs have been highly successful and have helped to contribute to the outstanding plant availability for the commissioned units at Yonggwang 3,4,5, and 6 and Ulchin 3,4,5, and 6; which are currently providing power on the grid. WEC has also recently delivered I and C equipment for Shin Kori Units 1 and 2 and Shin Wolsong Units 1 and 2 and is supporting the installation and startup of the equipment. In addition, WEC is in the initial design stages for providing an integrated protection system that will be deployed at Shin Kori Units 3 and 4 which are the first units to implement the APR1400; an advanced reactor of indigenous Korean design, which is based on the previous generation Optimized Power Reactor OPR1000. The success of the I and C programs has been the result of careful consideration of the appropriate technology to employ, applying comprehensive quality assurance measures, providing appropriate technical support and consultation services, implementation of a program of continued I and C logistic support, maintaining a professional and experienced I and C work force, and maintaining a strong and mutually supportive partnership with the Korea Power Engineering Company (KOPEC) and with Korea Hydro and Nuclear Power (KHNP). WEC takes great pride in its on going I and C partnership with Korea, which has included not only providing equipment and technical support services, but also completion of a comprehensive Technology Transfer program. This program was implemented to promote local 'elf

  11. Nonlinear transport processes in tokamak plasmas. I. The collisional regimes

    International Nuclear Information System (INIS)

    Sonnino, Giorgio; Peeters, Philippe

    2008-01-01

    An application of the thermodynamic field theory (TFT) to transport processes in L-mode tokamak plasmas is presented. The nonlinear corrections to the linear ('Onsager') transport coefficients in the collisional regimes are derived. A quite encouraging result is the appearance of an asymmetry between the Pfirsch-Schlueter (P-S) ion and electron transport coefficients: the latter presents a nonlinear correction, which is absent for the ions, and makes the radial electron coefficients much larger than the former. Explicit calculations and comparisons between the neoclassical results and the TFT predictions for Joint European Torus (JET) plasmas are also reported. It is found that the nonlinear electron P-S transport coefficients exceed the values provided by neoclassical theory by a factor that may be of the order 10 2 . The nonlinear classical coefficients exceed the neoclassical ones by a factor that may be of order 2. For JET, the discrepancy between experimental and theoretical results for the electron losses is therefore significantly reduced by a factor 10 2 when the nonlinear contributions are duly taken into account but, there is still a factor of 10 2 to be explained. This is most likely due to turbulence. The expressions of the ion transport coefficients, determined by the neoclassical theory in these two regimes, remain unaltered. The low-collisional regimes, i.e., the plateau and the banana regimes, are analyzed in the second part of this work

  12. Process of radiation damage in BaFX:Eu2+ (X=Br, I) photo-stimulable phosphor for imaging plate (IP)

    International Nuclear Information System (INIS)

    Kato, Munetaka; Takahashi, Kenji

    2005-01-01

    Imaging Plate (IP) is a 2-dimensional radiation detector utilizing photo-stimulable phosphors. Photo-stimulated luminescence (PSL) is a kind of process in radiation-induced reactions and IP can be repeatedly performed. The mechanism of PSL is reviewed and the radiation damage, which is a phenomenon that the luminescence goes down under X-ray irradiation, is also referred to. The relation between the composition of BaFX: Eu 2+ (X=Br, I), which is widely used in IPs, and the degree of radiation damage is investigated. The degree of radiation damage is smaller in the mixed crystal system of Br and I such as BaFBr 0.85 I 0.15 :Eu 2+ than in BaFBr: Eu 2+ and BaFI: Eu 2+ . This is explained by the characteristics of luminescence centers and F centers under X-ray irradiation. (author)

  13. Second International Conference on Near-Field Optical Analysis: Photodynamic Therapy and Photobiology Effects

    Science.gov (United States)

    Bulgher, Debra L. (Editor); Morrison, Dennis

    2002-01-01

    The International NASA/DARPA Photobiology Conference held at the Johnson Space Center in Houston/TX demonstrated where low level laser therapy (LLLT), respectively low intensity light activated biostimulation (LILAB) and nanotechnological applications employing photobiomodulation techniques will presumably go in the next ten years. The conference was a continuation of the 1st International Conference on Nearfield Optical Analysis organized by Andrei Sommer (ENSOMA Lab, University of Ulm, Germany) in November 2000 at Castle Reisenburg, Germany, which started with a group of ten scientists from eight different countries. The 1st conference was co-sponsored by the American Chemical Society to evaluate the molecular mechanism of accelerated and normal wound healing processes. The 2nd conference was co-sponsored by DARPA, NASA-JSC and the Medical College of Wisconsin. Despite the short time between events, the 2nd conference hosted 40 international experts form universities, research institutes, agencies and the industry. The materials published here are expected to become milestones forming a novel platform in biomedical photobiology. The multidisciplinary group of researchers focused on LLLT/LILAB-applications under extreme conditions expected to have beneficial effects particularly in space, on submarines, and under severe battlefield conditions. The group also focused on novel technologies with possibilities allowing investigating the interaction of light with biological systems, molecular mechanisms of wound healing, bone regeneration, nerve regeneration, pain modulation, as well as biomineralization and biofilm formulation processes induced by nanobacteria.

  14. Enzymatic characteristics of a recombinant neutral protease I (rNpI) from Aspergillus oryzae expressed in Pichia pastoris.

    Science.gov (United States)

    Ke, Ye; Huang, Wei-Qian; Li, Jia-zhou; Xie, Ming-quan; Luo, Xiao-chun

    2012-12-12

    A truncated neutral protease I (NpI) from Aspergillus oryzae 3.042 was expressed in Pichia pastoris with a high enzyme yield of 43101 U/mL. Its optimum pH was about 8.0, and it was stable in the pH range of 5.0-9.0. Its optimum temperature was about 55 °C and retained >90% activity at 50 °C for 120 min. Recombinant NpI (rNpI) was inhibited by Cu(2+) and EDTA. Eight cleavage sites of rNpI in oxidized insulin B-chain were determined by mass spectrometry, and five of them had high hydrophobic amino acid affinity, which makes it efficient in producing antihypertensive peptide IPP from β-casein and a potential debittering agent. The high degree of hydrolysis (DH) of rNpI to soybean protein (8.8%) and peanut protein (11.1%) compared to papain and alcalase makes it a good candidate in the processing of oil industry byproducts. The mutagenesis of H(429), H(433), and E(453) in the deduced zinc-binding motif confirmed rNpI as a gluzincin. All of these results show the great potential of rNpI to be used in the protein hydrolysis industry.

  15. I'm a Map, I'm a Green Tree

    Science.gov (United States)

    Anderson, Daniel

    2010-01-01

    I'm talking about the ways we represent ourselves and our world. I've put some thoughts on the topic together here--a gathering that enacts new media creating and takes up conceptual layers like metaphors, models, and composing. The primary sources are videos from the Get a Mac campaign, aka I'm a Mac; I'm a PC ads. Posthuman concepts blending…

  16. 41 CFR 304-3.8 - Must I adhere to the provisions of the Fly America Act when I receive air transportation to a...

    Science.gov (United States)

    2010-07-01

    ... 41 Public Contracts and Property Management 4 2010-07-01 2010-07-01 false Must I adhere to the provisions of the Fly America Act when I receive air transportation to a meeting furnished or paid by a non... provisions of the Fly America Act when I receive air transportation to a meeting furnished or paid by a non...

  17. A facile copper(I)-catalyzed homocoupling of terminal alkynes to 1,3-diynes with diaziridinone under mild conditions

    OpenAIRE

    Zhu, Yingguang; Shi, Yian

    2013-01-01

    A novel and efficient Cu(I)-catalyzed oxidative homocoupling of terminal alkynes with diaziridinone as oxidant is described. Various terminal alkynes can be transformed into the corresponding 1,3-diynes in good yields. The reaction process is base-free, operationally simple, and amenable to gram scale.

  18. Modern trends in increasing the quality of the steels intended for cutting and metal-working tools: I. Improvement of granule metallurgy processes

    Science.gov (United States)

    Belyanchikov, L. N.

    2008-12-01

    The following new technological processes for producing fine gas-atomized powders of tool and high-speed steels with a low content of nonmetallic inclusions are considered: the process designed by Böhler Uddeholm Powder Technology (Austria) and processes involving a heated gas. In the former process, a metal is poured from a ladle with electroslag heating, and the atomizing unit consists of three injectors. A new process of producing tools from fine powders by three-dimensional printing, i.e., so-called 3D-printing, is described.

  19. MoManI: a tool to facilitate research, analysis, and teaching of computer models

    Science.gov (United States)

    Howells, Mark; Pelakauskas, Martynas; Almulla, Youssef; Tkaczyk, Alan H.; Zepeda, Eduardo

    2017-04-01

    structure of MoManI allows different teams to collaborate simultaneously from around the globe. Each user can easily edit and update any part of the modelling process: from the underlying mathematical equations of OSeMOSYS through to the visualization of results. Going forward, this tools' flexible structure will make it a potential interface for a larger selection of modelling tools, thus extending its use from OSeMOSYS for energy to other systems modelling, moving beyond SDG7 to others.

  20. Instrument Control (iC) - An Open-Source Software to Automate Test Equipment.

    Science.gov (United States)

    Pernstich, K P

    2012-01-01

    It has become common practice to automate data acquisition from programmable instrumentation, and a range of different software solutions fulfill this task. Many routine measurements require sequential processing of certain tasks, for instance to adjust the temperature of a sample stage, take a measurement, and repeat that cycle for other temperatures. This paper introduces an open-source Java program that processes a series of text-based commands that define the measurement sequence. These commands are in an intuitive format which provides great flexibility and allows quick and easy adaptation to various measurement needs. For each of these commands, the iC-framework calls a corresponding Java method that addresses the specified instrument to perform the desired task. The functionality of iC can be extended with minimal programming effort in Java or Python, and new measurement equipment can be addressed by defining new commands in a text file without any programming.

  1. Discovery as a process

    Energy Technology Data Exchange (ETDEWEB)

    Loehle, C.

    1994-05-01

    The three great myths, which form a sort of triumvirate of misunderstanding, are the Eureka! myth, the hypothesis myth, and the measurement myth. These myths are prevalent among scientists as well as among observers of science. The Eureka! myth asserts that discovery occurs as a flash of insight, and as such is not subject to investigation. This leads to the perception that discovery or deriving a hypothesis is a moment or event rather than a process. Events are singular and not subject to description. The hypothesis myth asserts that proper science is motivated by testing hypotheses, and that if something is not experimentally testable then it is not scientific. This myth leads to absurd posturing by some workers conducting empirical descriptive studies, who dress up their study with a ``hypothesis`` to obtain funding or get it published. Methods papers are often rejected because they do not address a specific scientific problem. The fact is that many of the great breakthroughs in silence involve methods and not hypotheses or arise from largely descriptive studies. Those captured by this myth also try to block funding for those developing methods. The third myth is the measurement myth, which holds that determining what to measure is straightforward, so one doesn`t need a lot of introspection to do science. As one ecologist put it to me ``Don`t give me any of that philosophy junk, just let me out in the field. I know what to measure.`` These myths lead to difficulties for scientists who must face peer review to obtain funding and to get published. These myths also inhibit the study of science as a process. Finally, these myths inhibit creativity and suppress innovation. In this paper I first explore these myths in more detail and then propose a new model of discovery that opens the supposedly miraculous process of discovery to doser scrutiny.

  2. Una nueva <i>Armeria> del Sistema Central (España: <i>A. rivasmartineziii> (Plumbaginaceae

    Directory of Open Access Journals (Sweden)

    Sardinero, Santiago

    1997-12-01

    Full Text Available A new taxon from the central-western Sistema Central (Sierra de Béjar and Sierra de Tormantos, Spain, <i>Armeria rivasmartineziii>. is described and illustrated. lts morphological affinities and variability are discussed in concordance with its hypothetical hybrid origin.

    Se describe e ilustra un nuevo taxon del centro-occidente del Sistema Central español. <i>Armeria rivasmartineziii>. Se discuten sus afinidades morfológicas y variabilidad en concordancia con su hipotético origen híbrido.

  3. Linguistic expressions and semantic processing a practical approach

    CERN Document Server

    Butler, Alastair

    2015-01-01

    This book introduces formal semantics techniques for a natural language processing audience. Methods discussed involve: (i) the denotational techniques used in model-theoretic semantics, which make it possible to determine whether a linguistic expression is true or false with respect to some model of the way things happen to be; and (ii) stages of interpretation, i.e., ways to arrive at meanings by evaluating and converting source linguistic expressions, possibly with respect to contexts, into output (logical) forms that could be used with (i). The book demonstrates that the methods allow w

  4. A biomimetic strategy to form calcium phosphate crystals on type I collagen substrate

    Energy Technology Data Exchange (ETDEWEB)

    Xu Zhang [Department of Restorative Dentistry, Faculty of Dentistry, National University of Singapore, 5 Lower Kent Ridge Road 119074, Singapore (Singapore); Neoh, Koon Gee [Department of Chemical and Biomolecular Engineering, National University of Singapore, Kent Ridge 119260, Singapore (Singapore); Kishen, Anil, E-mail: anil.kishen@utoronto.ca [Discipline of Endodontics, Faculty of Dentistry, University of Toronto, 124 Edward Street, Toronto, ON (Canada)

    2010-07-20

    Objective: The aim of this study is to induce mineralization of collagen by introducing phosphate groups onto type I collagen from eggshell membrane (ESM) by treating with sodium trimetaphosphate (STMP). This strategy is based on the hypothesis that phosphate groups introduced on collagen can mimic the nucleating role of phosphorylated non-collagenous proteins bound to collagen for inducing mineralization in natural hard tissue. Method: The collagen membrane was phosphorylated by treating it with a solution of STMP and saturated calcium hydroxide. The phosphorylated collagen was subsequently exposed to a mineralization solution and the pattern of mineralization on the surface of phosphorylated collagen substrate was analyzed. Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), field emission electron microscopy (FESEM), energy-dispersive X-ray spectroscopy (EDX), X-ray diffraction (XRD) and microhardness test were used to characterize the collagen substrate and the pattern of minerals formed on the collagen surface. Results: The FTIR and EDX results indicated that the phosphate groups were incorporated onto the collagen surface by treatment with STMP. During the mineralization process, the plate-like mineral, octacalcium phosphate (OCP), which was initially formed on the surface of ESM, was later transformed into needle-like hydroxyapatite (HAP) as indicated by the SEM, FESEM, EDX and XRD findings. The microhardness test displayed significant increase in the Knoop hardness number of the mineralized collagen. Conclusions: Phosphate groups can be introduced onto type I collagen surface by treating it with STMP and such phosphorylated collagen can induce the mineralization of type I collagen.

  5. Induced adult stem (iAS) cells and induced transit amplifying progenitor (iTAP) cells-a possible alternative to induced pluripotent stem (iPS) cells?

    Science.gov (United States)

    Heng, Boon Chin; Richards, Mark; Ge, Zigang; Shu, Yimin

    2010-02-01

    The successful derivation of iPSC lines effectively demonstrates that it is possible to reset the 'developmental clock' of somatic cells all the way back to the initial embryonic state. Hence, it is plausible that this clock may instead be turned back half-way to a less immature developmental stage that is more directly applicable to clinical therapeutic applications or for in vitro pharmacology/toxicology screening assays. Such a suitable developmental state is postulated to be either the putative transit amplifying progenitor stage or adult stem cell stage. It is hypothetically possible to reprogram mature and terminally differentiated somatic cells back to the adult stem cell or transit amplifying progenitor stage, in a manner similar to the derivation of iPSC. It is proposed that the terminology 'Induced Adult Stem Cells' (iASC) or 'Induced Transit Amplifying Progenitor Cells' (iTAPC) be used to described such reprogrammed somatic cells. Of particular interest, is the possibility of resetting the developmental clock of mature differentiated somatic cells of the mesenchymal lineage, explanted from adipose tissue, bone marrow and cartilage. The putative adult stem cell sub-population from which these cells are derived, commonly referred to as 'mesenchymal stem cells', are highly versatile and hold much therapeutic promise in regenerative medicine, as attested to by numerous human clinical trials and animal studies. Perhaps it may be appropriate to term such reprogrammed cells as 'Induced Mesenchymal Stem Cells' (iMSC) or as 'Induced Mesenchumal Progenitor Cells' (iMPC). Given that cells from the same organ/tissue will share some commonalities in gene expression, we hypothesize that the generation of iASC or iTAPC would be more efficient as compared to iPSC generation, since a common epigenetic program must exist between the reprogrammed cells, adult stem cell or progenitor cell types and terminally differentiated cell types from the same organ/tissue.

  6. Differential binding of 125I-IGF-I preparations to human fibroblast monolayers

    International Nuclear Information System (INIS)

    Conover, C.A.; Misra, P.; Hintz, R.L.; Rosenfeld, R.G.

    1988-01-01

    Specific, high affinity binding of 125 I-IGF-I to the type IIGF receptor on human fibroblast monolyaers was not altered by varying feeding schedules, serum lots, washing procedures, or incubation times and temperatures. However, markedly different competitive binding curves were obtained when different iodinated IGF-I preparations were used. Five of six radioligands bound preferentially to the type IIGF receptor on human fibroblast monolayers, with 50% displacement at 4-8 μg/l unlabelled IGF-I; with one radioligand a paradoxical 20-200% increase in 125 I-IGF-I binding was observed at low concentrations of unlabelled IGF-I, while concentrations as high as 100 μg/l IGF-I failed to displace this radioligand. The latter binding pattern cannot be accounted for by 125 -I-IGF-I binding to the type II IGF receptor. These data indicate that various radioligands may have preferential affinities for different IGF-I binding sites on human fibroblast monolayers. (author)

  7. DOE-DARPA High-Performance Corrosion-Resistant Materials (HPCRM), Annual HPCRM Team Meeting & Technical Review

    Energy Technology Data Exchange (ETDEWEB)

    Farmer, J; Brown, B; Bayles, B; Lemieux, T; Choi, J; Ajdelsztajn, L; Dannenberg, J; Lavernia, E; Schoenung, J; Branagan, D; Blue, C; Peter, B; Beardsley, B; Graeve, O; Aprigliano, L; Yang, N; Perepezko, J; Hildal, K; Kaufman, L; Lewandowski, J; Perepezko, J; Hildal, K; Kaufman, L; Lewandowski, J; Boudreau, J

    2007-09-21

    The overall goal is to develop high-performance corrosion-resistant iron-based amorphous-metal coatings for prolonged trouble-free use in very aggressive environments: seawater & hot geothermal brines. The specific technical objectives are: (1) Synthesize Fe-based amorphous-metal coating with corrosion resistance comparable/superior to Ni-based Alloy C-22; (2) Establish processing parameter windows for applying and controlling coating attributes (porosity, density, bonding); (3) Assess possible cost savings through substitution of Fe-based material for more expensive Ni-based Alloy C-22; (4) Demonstrate practical fabrication processes; (5) Produce quality materials and data with complete traceability for nuclear applications; and (6) Develop, validate and calibrate computational models to enable life prediction and process design.

  8. Decomposing Petri nets for process mining : a generic approach

    NARCIS (Netherlands)

    Aalst, van der W.M.P.

    2012-01-01

    The practical relevance of process mining is increasing as more and more event data become available. Process mining techniques aim to discover, monitor and improve real processes by extracting knowledge from event logs. The two most prominent process mining tasks are: (i) process discovery:

  9. Functional Fault Model Development Process to Support Design Analysis and Operational Assessment

    Science.gov (United States)

    Melcher, Kevin J.; Maul, William A.; Hemminger, Joseph A.

    2016-01-01

    A functional fault model (FFM) is an abstract representation of the failure space of a given system. As such, it simulates the propagation of failure effects along paths between the origin of the system failure modes and points within the system capable of observing the failure effects. As a result, FFMs may be used to diagnose the presence of failures in the modeled system. FFMs necessarily contain a significant amount of information about the design, operations, and failure modes and effects. One of the important benefits of FFMs is that they may be qualitative, rather than quantitative and, as a result, may be implemented early in the design process when there is more potential to positively impact the system design. FFMs may therefore be developed and matured throughout the monitored system's design process and may subsequently be used to provide real-time diagnostic assessments that support system operations. This paper provides an overview of a generalized NASA process that is being used to develop and apply FFMs. FFM technology has been evolving for more than 25 years. The FFM development process presented in this paper was refined during NASA's Ares I, Space Launch System, and Ground Systems Development and Operations programs (i.e., from about 2007 to the present). Process refinement took place as new modeling, analysis, and verification tools were created to enhance FFM capabilities. In this paper, standard elements of a model development process (i.e., knowledge acquisition, conceptual design, implementation & verification, and application) are described within the context of FFMs. Further, newer tools and analytical capabilities that may benefit the broader systems engineering process are identified and briefly described. The discussion is intended as a high-level guide for future FFM modelers.

  10. Process limitations of a whole-cell P450 catalyzed reaction using a CYP153A-CPR fusion construct expressed in <i>Escherichia colii>

    DEFF Research Database (Denmark)

    Lundemo, M. T.; Notonier, S.; Striedner, G.

    2016-01-01

    fatty acids at the terminal position. ω-Hydroxylated fatty acids can be used in the field of high-end polymers and in the cosmetic and fragrance industry. Here, we have identified the limitations for implementation of a whole-cell P450-catalyzed reaction by characterizing the chosen biocatalyst as well......Cytochrome P450s are interesting biocatalysts due to their ability to hydroxylate non-activated hydrocarbons in a selective manner. However, to date only a few P450-catalyzed processes have been implemented in industry due to the difficulty of developing economically feasible processes...

  11. A facile copper(I)-catalyzed homocoupling of terminal alkynes to 1,3-diynes with diaziridinone under mild conditions.

    Science.gov (United States)

    Zhu, Yingguang; Shi, Yian

    2013-11-21

    A novel and efficient Cu(I)-catalyzed oxidative homocoupling of terminal alkynes with diaziridinone as an oxidant is described. Various terminal alkynes can be transformed into the corresponding 1,3-diynes in good yields. The reaction process is base-free, operationally simple, and amenable to the gram scale.

  12. Strategic Laser Communications Program. Volume 1. Proceedings of the Navy/DARPA Fourth Technical Interchange Meeting, 25-27 March 1980

    Science.gov (United States)

    1980-07-31

    r wc z > IK z ul z w U- L.. 0cLL LLz ILlO W: LJ1- V. LLJ (D or40 0 LA% - a P.-1 . ~ W.- WO W LLJ ~ 2c I- -gV"C LL WL LL- 0i Wix I I Cý Lai caL ) - u...that shadowing effects on our irradiance measurements were negligible (except at high noon). The barge provided a platform where rapid, efficient and

  13. Sorting mutual funds with respect to process-oriented social responsibility: A FLOWSORT application

    Directory of Open Access Journals (Sweden)

    Tim Verheyden

    2014-08-01

    Full Text Available We establish a robust FLOWSORT-based tool to sort mutual funds with respect to process-oriented social responsibility and recommend the use of limiting profiles with open classes. The tool provides an alternative for the limited dichotomous classification of funds, i.e. socially responsible investing (SRI versus conventional funds. By allowing for more heterogeneity in social responsibility the sorting tool is promising for scholars to improve fund performance measurements, and useful for governments to better regulate the supply of SRI products.

  14. Process Technical Basis Documentation Diagram for a solid-waste processing facility

    International Nuclear Information System (INIS)

    Benar, C.J.; Petersen, C.A.

    1994-02-01

    The Process Technical Basis Documentation Diagram is for a solid-waste processing facility that could be designed to treat, package, and certify contact-handled mixed low-level waste for permanent disposal. The treatment processes include stabilization using cementitious materials and immobilization using a polymer material. The Diagram identifies several engineering/demonstration activities that would confirm the process selection and process design. An independent peer review was conducted at the request of Westinghouse Hanford Company to determine the technical adequacy of the technical approach for waste form development. The peer review panel provided comments and identified documents that it felt were needed in the Diagram as precedence for Title I design. The Diagram is a visual tool to identify traceable documentation of key activities, including those documents suggested by the peer review, and to show how they relate to each other. The Diagram is divided into three sections: (1) the Facility section, which contains documents pertaining to the facility design, (2) the Process Demonstration section, which contains documents pertaining to the process engineering/demonstration work, and 3) the Regulatory section, which contains documents describing the compliance strategy for each acceptance requirement for each feed type, and how this strategy will be implemented

  15. Organization of educational process at the department of human anatomy of Saratov State Medical University n.a. V. I. Razumovsky

    Directory of Open Access Journals (Sweden)

    Bugaeva I0

    2017-06-01

    Full Text Available Human anatomy is one of the basic disciplines in the system of medical education. Knowledge in this area is necessary for the development of related theoretical subjects and constitutes a basis for studying clinical disciplines. Therefore the priority task of department of human anatomy is qualitative training of students at the modern level using classical and innovative pedagogical and computer technologies, being based on competence-based approach to training. In the article the features of organization of educational process at department of Human Anatomy of Saratov State Medical University n.a. V. I. Razumovsky, within the Federal state educational standard of the 3rd generation which key differences are considered: acquisition by students of cultural and professional competences.

  16. DARPA Robotics Challenge (DRC) Using Human-Machine Teamwork to Perform Disaster Response with a Humanoid Robot

    Science.gov (United States)

    2017-02-01

    leverage our tools and skills to develop a system in which we can get the simulated government furnished equipment (GFE) robot to walk over various types...our control software to the constellation and made a small helper program that gave us the possibility to restart our control software should...avoided this way. - The time and bandwidth limits caused us to integrate helper tools based on computer vision and a microphone sensor into the robot

  17. Using CART to segment road images

    Science.gov (United States)

    Davies, Bob; Lienhart, Rainer

    2006-01-01

    The 2005 DARPA Grand Challenge is a 132 mile race through the desert with autonomous robotic vehicles. Lasers mounted on the car roof provide a map of the road up to 20 meters ahead of the car but the car needs to see further in order to go fast enough to win the race. Computer vision can extend that map of the road ahead but desert road is notoriously similar to the surrounding desert. The CART algorithm (Classification and Regression Trees) provided a machine learning boost to find road while at the same time measuring when that road could not be distinguished from surrounding desert.

  18. Analysis of a child infected with [i]Hymenolepis[/i] [i]diminuta[/i] in Poland

    Directory of Open Access Journals (Sweden)

    Przemysław Kołodziej

    2014-09-01

    Full Text Available [i]Hymenolepis diminuta[/i] is a cosmopolitan parasite of rats and mice which is very rare in humans. This study presents the case of a 3-year-old boy infected with [i]Hymenolepis diminuta[/i] in Poland. The diagnosis was based on eggs found and their morphology in the patient’s stool.

  19. Caveolin-1-mediated apolipoprotein A-I membrane binding sites are not required for cholesterol efflux.

    Directory of Open Access Journals (Sweden)

    Soazig Le Lay

    Full Text Available Caveolin-1 (Cav1, a structural protein required for the formation of invaginated membrane domains known as caveolae, has been implicated in cholesterol trafficking and homeostasis. Here we investigated the contribution of Cav1 to apolipoprotein A-I (apoA-I cell surface binding and intracellular processing using mouse embryonic fibroblasts (MEFs derived from wild type (WT or Cav1-deficient (Cav1(-/- animals. We found that cells expressing Cav1 have 2.6-fold more apoA-I binding sites than Cav1(-/- cells although these additional binding sites are not associated with detergent-free lipid rafts. Further, Cav1-mediated binding targets apoA-I for internalization and degradation and these processes are not correlated to cholesterol efflux. Despite lower apoA-I binding, cholesterol efflux from Cav1(-/- MEFs is 1.7-fold higher than from WT MEFs. Stimulation of ABCA1 expression with an LXR agonist enhances cholesterol efflux from both WT and Cav1(-/- cells without increasing apoA-I surface binding or affecting apoA-I processing. Our results indicate that there are at least two independent lipid binding sites for apoA-I; Cav1-mediated apoA-I surface binding and uptake is not linked to cholesterol efflux, indicating that membrane domains other than caveolae regulate ABCA1-mediated cholesterol efflux.

  20. Evaluating Process Effectiveness to Reduce Risk

    Science.gov (United States)

    Shepherd, Christena C.

    2017-01-01

    It is well documented that government agencies do not have the same incentive as the private sector to focus on process effectiveness and continual improvement of those processes. It is also well documented whenever government agencies fail to deliver efficient, effective, consistent, and fair services to the citizens. In spite of the various "reinventing government" and "effectiveness initiatives" of the past decades, and in spite of the efforts on the part of many agencies to improve, government in general still lags behind industry in creating a culture of effective processes and systems. While the tragic events that unfolded recently in Flint, Michigan, teach us that running government "like a business" does not always take the needs of the citizenry into account, there are many lessons and techniques from the private sector that government agencies can use to improve. The incentive to improve, while mandated by various administrations1, needs to come from within the workforce, in order to effectively take root. The best, most effective incentive is to reduce, control or eliminate risk. Government agencies face some of the same risks as the private sector, while some are unique. While ISO 310002 has been around since 2009, risk has taken on increased visibility within the private sector with the advent of the emphasis on risk-based thinking in ISO 9001:20153. The relationship between risk-based thinking and effective processes is simple and direct. Those processes that are well thought out and standardized (i.e. Plan-Do-Check-Act), will have taken into account the applicable policy, statutory, regulatory, safety, quality and technical parameters, which may not occur to someone performing the process with minimal experience or training; and thus protect the employees, the public and the agency from statutory and regulatory violations; delay in providing services; non-delivery of services; harm to public or employee safety and health; cost overruns; breaches in

  1. A Review of the Soldier’s Equipment Burden

    Science.gov (United States)

    2011-12-01

    allow heavy items to be packed close to the soldier’s natural centre of mass . The Infantryman, with such a large equipment burden, is in effect...COM Centre of Mass COTS Commercial Off-the-Shelf CPL Corporal DARPA Defense Advanced Research Project Agency DMO Defence Materiel...Eighteen soldiers had customised their packs, either the issued packs or their own. The most common customisation was the addition of an external

  2. iOS Sensor Apps with Arduino Wiring the iPhone and iPad into the Internet of Things

    CERN Document Server

    Allan, Alasdair

    2011-01-01

    Turn your iPhone or iPad into the hub of a distributed sensor network with the help of an Arduino microcontroller. With this concise guide, you'll learn how to connect an external sensor to an iOS device and have them talk to each other through Arduino. You'll also build an iOS application that will parse the sensor values it receives and plot the resulting measurements, all in real-time. iOS processes data from its own onboard sensors, and now you can extend its reach with this simple, low-cost project. If you're an Objective-C programmer who likes to experiment, this book explains the basi

  3. Test processing integrated system (S.I.D.E.X.)

    International Nuclear Information System (INIS)

    Sabas, M.; Oules, H.; Badel, D.

    1969-01-01

    The Test Processing Integrated System is mostly composed of a CAE 9080 (equiv. S. D. S. 9300) computer which is equipped of a 100 000 samples/sec acquisition system. The System is designed for high speed data acquisition and data processing on environment tests, and also calculation of structural models. Such a digital appliance on data processing has many advantages compared to the conventional methods based on analog instruments. (author) [fr

  4. Development of a recovery method of {sup 131}I in the {sup 99}Mo process through the fission of 235{sup U}; Desenvolvimento de metodo de recuperacao de {sup 131}I no processo de producao de 99{sup M}o pela fissao de 2{sup 35}U

    Energy Technology Data Exchange (ETDEWEB)

    Bignardi, Aline Moraes Teixeira

    2013-07-01

    {sup 13}1{sup I} is an iodine radioisotope widely used in nuclear medicine that can be used either for diagnostic or for treatment due to its physical decay by {beta}{sup -} and its high emission of y-rays. It is produced at IPEN using the indirect reaction: {sup 130}Te(n,y){sup 131m}Te {yields} {sup 131}Te {yields} {sup 131}I where TeO{sub 2} targets are irradiated in a Nuclear Reactor. There is also the possibility of producing {sup 131}I by the fission of {sup 235}U, where about 300 different elements are produced together with {sup 131}I. The {sup 131}I produced through this method presents high specific activity and radioactive concentration suitable for the labeling of molecules. The aim of this work was to develop a recovery method of {sup 131}I with the required quality to be used in Nuclear Medicine in the {sup 99}Mo production process through the route of acid dissolution of metallic {sup 235}U targets. {sup 131}I can appear in two phases of the process, both in the gaseous phase produced during the dissolution of metallic U targets and in the dissolution solution. This work studied the recovery of {sup 131}I in these two phases. Several materials were used for the capture and recovery of {sup 131}I at the two phases of the process, the gaseous one and the solution of dissolution of U targets. Columns of alumina with Cu, acid alumina with Cu, Ag microspheres, Cu microspheres, Ag nanospheres, anionic cartridges, Ag cartridges, anion exchange resin and activated charcoal columns were tested. Solutions containing {sup 131}I in 0.1 mol.L{sup -1} NaOH were percolated through the materials and the eluted solutions were analyzed in a dose calibrator. The precipitation of AgI was also studied wth further dissolution of this precipitate with 0.1 mol L{sup -1} NH{sub 4}OH and 5% Na{sub 2}S{sub 2}O{sub 3}. The recovery results varied according to the material, activated charcoal showed recovery yields between 42% and 83% but the recovery yield of the alumina column

  5. High incidence of antibodies to HTLV-I tax in blood relatives of adult T cell leukemia patients.

    Science.gov (United States)

    Okayama, A; Chen, Y M; Tachibana, N; Shioiri, S; Lee, T H; Tsuda, K; Essex, M

    1991-01-01

    Adult T cell leukemia (ATL) is caused by the human T cell leukemia virus type I (HTLV-I). Although the mechanisms of the leukemogenic process are unknown, the tax gene may have a role in this process. Because clustering occurs with HTLV-I and ATL, members of ATL families were examined for antibodies to the tax protein and compared with matched HTLV-I-positive blood donors. To investigate the antibody response to this protein, a plasmid, pBHX-4, was constructed to express a recombinant tax protein (r-tax). For ATL patients and their HTLV-I antibody-positive blood relatives, the rate of seroreactivity with the r-tax protein was 67.3% (35/52), compared with 51.6% (97/188) for HTLV-I antibody-positive control blood donors (P less than .05). The difference between direct offspring of ATL patients and matched HTLV-I blood donors was even greater (84.2% [16/91] vs. 44.2% [42/95]; P less than .005). Thus, tax antibody positivity in direct offspring of ATL patients may reflect differences in time or route of HTLV-I infection. Alternatively, it might reflect genetic differences in host susceptibility or virus strain.

  6. The contribution of I. I. Tegako to anthropology of Belarus

    Directory of Open Access Journals (Sweden)

    Hurbo Tatyana

    2016-01-01

    Full Text Available L.I. Tegako started her studies of anthropology in the middle of 1960s when she received her research degree. The scope of her scientific interest included odontology and dermatoglyphics. For more than 40 years L.I. Tegako was a permanent supervisor of the group and later of the Anthropology department. From the beginning of 1970s Belarusian anthropologists started conducting complex anthropologic studies of the adult population of the republic in various parts of the country (anthropometry, anthroposcopy, dermatoglyphics, blood group factor. Comprehensive approach became the basis for studies of anthropogenic variety of local population on the territory of Belarus. In 1998 the team of anthropologists supervised by L.I. Tegako won a State Prize of the Republic of Belarus for the scope of work on the topic 'Person and his biocultural adaptation'. In 2000s the scope of L.I. Tegako's scientific interest included the determination of intersystemic correlations between dermatoglyphical and psychosomatic characteristics. During her academic career, L.I. Tegako published 17 monographs, 6 study guides, 11 brochures and 209 research papers. Lidiya Ivanovna worked at leading universities in the country; she had 7 students who completed PhD thesis. Since 1999 she worked as a professor of biology. L.I. Tegako deserves a credit for the organization of anthropological conferences in Minsk. She devoted a lot of attention to the international cooperation. As a result, L.I. Tegako contributed to the establishment of stable scientific and friendly ties with Serbian colleagues: Institute of History of the NAS of Belarus and Matica Srpska made a partnership agreement. This includes exchange of experience, scientific works, and realization of joint projects.

  7. Production Engineering Program to Develop Improved Mass-Production Process for M42/M46 Grenade Bodies

    Science.gov (United States)

    1978-03-01

    j~l~05- 4.00 ".490-:010 I MAT’L:- AISI 4140 , SPEC ASTM A507 I DOME, GRENADE M46 (For Inertia Welding Process) Figure 1 31...piece assembly consisting of a cylinder fabricated from embossed 4140 steel in a tube mill and attached by furnace brazing to an embossed dome...that the following three processes would receive in-depth study and inve.stigation: I. Emboss coiled 4140 steel flat stock in a Fenn mill to give the

  8. Ulighed i sundhed

    DEFF Research Database (Denmark)

    Uligheden i sundhed er stigende i Danmark trods et mangeårigt politisk fokus på at bekæmpe den. Bogen bidrager med viden om de komplekse processer, hvori ulighed i sundhed opstår og reproduceres. Bogens kapitler handler bl.a. om: Mænd og sundhed Klasse, sundhed og subjekt Overvægt Mental sundhed,...

  9. Airborne Video Surveillance

    National Research Council Canada - National Science Library

    Blask, Steven

    2002-01-01

    The DARPA Airborne Video Surveillance (AVS) program was established to develop and promote technologies to make airborne video more useful, providing capabilities that achieve a UAV force multiplier...

  10. The Iterative Design Process in Research and Development: A Work Experience Paper

    Science.gov (United States)

    Sullivan, George F. III

    2013-01-01

    The iterative design process is one of many strategies used in new product development. Top-down development strategies, like waterfall development, place a heavy emphasis on planning and simulation. The iterative process, on the other hand, is better suited to the management of small to medium scale projects. Over the past four months, I have worked with engineers at Johnson Space Center on a multitude of electronics projects. By describing the work I have done these last few months, analyzing the factors that have driven design decisions, and examining the testing and verification process, I will demonstrate that iterative design is the obvious choice for research and development projects.

  11. Analysis of Data from a Series of Events by a Geometric Process Model

    Institute of Scientific and Technical Information of China (English)

    Yeh Lam; Li-xing Zhu; Jennifer S. K. Chan; Qun Liu

    2004-01-01

    Geometric process was first introduced by Lam[10,11]. A stochastic process {Xi, i = 1, 2,…} is called a geometric process (GP) if, for some a > 0, {ai-1Xi, i = 1, 2,…} forms a renewal process. In thispaper, the GP is used to analyze the data from a series of events. A nonparametric method is introduced forthe estimation of the three parameters in the GP. The limiting distributions of the three estimators are studied.Through the analysis of some real data sets, the GP model is compared with other three homogeneous andnonhomogeneous Poisson models. It seems that on average the GP model is the best model among these fourmodels in analyzing the data from a series of events.

  12. A Functional Examination of Intermediate Cognitive Processes.

    Science.gov (United States)

    1986-01-01

    in terms of levels of processing models (e.g., Craik and Lockhart , 1972; Craik and Tulving, 1975). A similarly counter-intuitive result from a novel...NJ.: Erlbaum. Craik ,F.I.M. & Lockhart ,R.S. (1972). Levels of processing : A framework for memory research. Journal of Verbal Learning and Verbal... processes or at least, a recognition of the correspondence betveen these symbols and external events. ( Craik , 1943, p. 50) Craik thus provides a

  13. The AquaDEB project (phase I): Analysing the physiological flexibility of aquatic species and connecting physiological diversity to ecological and evolutionary processes by using Dynamic Energy Budgets

    Science.gov (United States)

    Alunno-Bruscia, Marianne; van der Veer, Henk W.; Kooijman, Sebastiaan A. L. M.

    2009-08-01

    The European Research Project AquaDEB (2007-2011, http://www.ifremer.fr/aquadeb/) is joining skills and expertise of some French and Dutch research institutes and universities to analyse the physiological flexibility of aquatic organisms and to link it to ecological and evolutionary processes within a common theoretical framework for quantitative bioenergetics [Kooijman, S.A.L.M., 2000. Dynamic energy and mass budgets in biological systems. Cambridge University Press, Cambridge]. The main scientific objectives in AquaDEB are i) to study and compare the sensitivity of aquatic species (mainly molluscs and fish) to environmental variability of natural or human origin, and ii) to evaluate the related consequences at different biological levels (individual, population, ecosystem) and temporal scales (life cycle, population dynamics, evolution). At mid-term life, the AquaDEB collaboration has already yielded interesting results by quantifying bio-energetic processes of various aquatic species (e.g. molluscs, fish, crustaceans, algae) with a single mathematical framework. It has also allowed to federate scientists with different backgrounds, e.g. mathematics, microbiology, ecology, chemistry, and working in different fields, e.g. aquaculture, fisheries, ecology, agronomy, ecotoxicology, climate change. For the two coming years, the focus of the AquaDEB collaboration will be in priority: (i) to compare energetic and physiological strategies among species through the DEB parameter values and to identify the factors responsible for any differences in bioenergetics and physiology; and to compare dynamic (DEB) versus static (SEB) energy models to study the physiological performance of aquatic species; (ii) to consider different scenarios of environmental disruption (excess of nutrients, diffuse or massive pollution, exploitation by man, climate change) to forecast effects on growth, reproduction and survival of key species; (iii) to scale up the models for a few species from

  14. Why I Am Not SHY: A Reply to Tononi and Cirelli

    Directory of Open Access Journals (Sweden)

    Marcos Gabriel Frank

    2013-01-01

    Full Text Available In a recent article I reviewed an influential theory of sleep function, the “synaptic homeostasis hypothesis (SHY.” According to SHY, sleep renormalizes synapses that are potentiated during prior wakefulness. I concluded that while SHY is a seminal theory with important implications about sleep function and the brain, its underlying mechanisms are poorly defined. In an accompanying article, the authors of SHY responded at length. Their reply is thoughtful and provocative, but unfortunately many of the points I raised were not accurately represented or addressed. In this brief commentary, I attempt to clarify some points of confusion. I also explain why any theory of sleep function is incomplete without an understanding of the underlying cellular mechanisms.

  15. NETEX Task 1: a study of the effect of ultrawideband (UWB) emitters on existing narrowband military receivers

    Science.gov (United States)

    Light, Arthur H.; Griggs, Stephen

    2003-07-01

    The goal of the DARPA NETEX program is to create a wireless networking technology for the military user that enables robust connectivity in harsh environments and support its integration into new and emerging sensor and communication systems. Phase 1 resulted in a thorough understanding of the effects of UWB system operation on existing military spectrum users based on modeling, simulation, and measurements. DARPA procured UWB emitters and broadband antennas to use as interference sources and contracted with the NAWC AD to provide candidate victim systems from the existing US inventory for testing. Testing was conducted on thirteen systems from October 2002 through March 2003. The purpose of this paper is to describe the results of these tests. It will provide a brief definition of UWB emissions as described by the US FCC and describe the generic UWB emitter used for these tests. It will then provide a brief overview of the general test plan and explain how it was adapted to the various systems tested. It will then provide a discussion of the results as they apply to the purpose of the NETEX program. Finally, the paper will look at where NETEX is going after Task 1.

  16. Statistical process control applied to intensity modulated radiotherapy pretreatment controls with portal dosimetry

    International Nuclear Information System (INIS)

    Villani, N.; Noel, A.; Villani, N.; Gerard, K.; Marchesi, V.; Huger, S.; Noel, A.; Francois, P.

    2010-01-01

    Purpose The first purpose of this study was to illustrate the contribution of statistical process control for a better security in intensity modulated radiotherapy (I.M.R.T.) treatments. This improvement is possible by controlling the dose delivery process, characterized by pretreatment quality control results. So, it is necessary to put under control portal dosimetry measurements (currently, the ionisation chamber measurements were already monitored by statistical process control thanks to statistical process control tools). The second objective was to state whether it is possible to substitute ionisation chamber with portal dosimetry in order to optimize time devoted to pretreatment quality control. Patients and methods At Alexis-Vautrin center, pretreatment quality controls in I.M.R.T. for prostate and head and neck treatments were performed for each beam of each patient. These controls were made with an ionisation chamber, which is the reference detector for the absolute dose measurement, and with portal dosimetry for the verification of dose distribution. Statistical process control is a statistical analysis method, coming from industry, used to control and improve the studied process quality. It uses graphic tools as control maps to follow-up process, warning the operator in case of failure, and quantitative tools to evaluate the process toward its ability to respect guidelines: this is the capability study. The study was performed on 450 head and neck beams and on 100 prostate beams. Results Control charts, showing drifts, both slow and weak, and also both strong and fast, of mean and standard deviation have been established and have shown special cause introduced (manual shift of the leaf gap of the multi-leaf collimator). Correlation between dose measured at one point, given with the E.P.I.D. and the ionisation chamber has been evaluated at more than 97% and disagreement cases between the two measurements were identified. Conclusion The study allowed to

  17. Improvement of the obtention process of {sup 131} I of ININ through studies of equipment design and process parameters fitting in the simulator; Perfeccionamiento del proceso de obtencion del {sup 131} I del ININ mediante estudios de diseno del equipo y ajustes de parametros del proceso en el simulador

    Energy Technology Data Exchange (ETDEWEB)

    Zepeda M, M C

    2006-07-01

    The main objective of the work was to achieve a high yield of the reaction that happens among the vapors of {sup 131} I and the NaOH to obtain sodium iodide (Na{sup 131} I) in solution optimizing the contact time of the molecules in gaseous state of {sup 131} I with the NaOH molecules through the bubbling velocity of the {sup 131} I in the solution of NaOH 0.1 N, as well as the operation temperature during the distillation process by dry via starting from tellurium dioxide (TeO{sub 2}) with the purpose of that the {sup 131} I that is obtained in the form of Na{sup 131} I solution presents the necessary quality that allows to distribute it in the market. The particular objectives were: a) To improve the distillation equipment used for the obtaining of {sup 131} I starting from irradiated tellurium dioxide redrawing the dilution system with the purpose of recovering the {sup 131} I in a minimum volume of sodium hydroxide (NaOH). b) To achieve a bigger time of contact among the molecules of {sup 131} I in gaseous state with the molecules of NaOH in solution through the bubbling velocity and of the redrawing of the dilution system. c) To implement the production of {sup 131} I by dry distillation via starting from tellurium dioxide, obtaining it with a high radionuclide and radiochemical purity. d) To obtain {sup 131} I with the necessary specifications that it marks the pharmacopoeia and it can be used with medical ends. (Author)

  18. Familiarity Breeds Attempts: A Critical Review of Dual-Process Theories of Recognition.

    Science.gov (United States)

    Mandler, George

    2008-09-01

    Recognition memory and recall/recollection are the major divisions of the psychology of human memory. Theories of recognition have shifted from a "strength" approach to a dual-process view, which distinguishes between knowing that one has experienced an object before and knowing what it was. In this article, I discuss the history of this approach and the two processes of familiarity and recollection and locate their origin in pattern matching and organization. I evaluate various theories in terms of their basic requirements and their defining research and propose the extension of the original two process theory to domains such as pictorial recognition. Finally, I present the main phenomena that a dual-process theory of recognition must account for and discuss future needs and directions of research and development. © 2008 Association for Psychological Science.

  19. An open data repository and a data processing software toolset of an equivalent Nordic grid model matched to historical electricity market data

    Directory of Open Access Journals (Sweden)

    Luigi Vanfretti

    2017-04-01

    This Nordic 44 equivalent model was also used in iTesla project (iTesla [3] to carry out simulations within a dynamic security assessment toolset (iTesla, 2016 [4], and has been further enhanced during the ITEA3 OpenCPS project (iTEA3 [5]. The raw, processed data and output models utilized within the iTesla platform (iTesla, 2016 [4] are also available in the repository. The CIM and Modelica snapshots of the “Nordic 44” model for the year 2015 are available in a Zenodo repository.

  20. Kontrol og dynamik i pædagogiske processer

    DEFF Research Database (Denmark)

    Ahrenkiel, Annegrethe

    Afhandlingen kombinerer kritisk diskursanalyse (Fairclough) med Basil Bernsteins uddannelsessociologi mhp. at belyse, hvordan læring hhv. fremmes og hæmmes i pædagogisk praksis. Empirisk vises det bl.a. med en tekstnær, lingvistisk analyse af en klasserumssamtale fra en daghøjskole. Afhandlingen...

  1. Low Achieving Eighth Graders Learn to Crack Word Problems: A Design Research Project for Aligning a Strategic Scaffolding Tool to Students' Mental Processes

    Science.gov (United States)

    Prediger, Susanne; Krägeloh, Nadine

    2015-01-01

    Topic-specific didactical design research provides means not only to investigate how to learn but also what to learn, i.e., for specifying learning contents by analyzing students' comprehension processes in detail. This important characteristic of didactical design research is exemplarily shown for students' difficulties in finding symbolic…

  2. Exploring the iPhone Backup made by iTunes

    Directory of Open Access Journals (Sweden)

    Mario Piccinelli

    2011-09-01

    Full Text Available The iPhone mobile from Apple Inc. is one of the most notable phones on the market thanks to its simple and user-friendly interface and ever growing pool of available high quality applications for both personal and business use. The increasing use of iPhone mobiles leads forensics practitioners towards the need for tools to access and analyze the information stored in the device. This research aims at describing how to forensically analyze a logical backup of an iPhone made by the Apple iTunes utility, understanding its structure and creating a simple tool to automate the process of decoding and analyzing the data. It was found that significant data of forensic value such as e-mail messages, text and multimedia messages, calendar events, browsing history, GPRS locations, contacts, call history and voicemail recordings can be retrieved using this method of iPhone acquisition.

  3. A multisensor approach to sea ice classification for the validation of DMSP-SSM/I passive microwave derived sea ice products

    Science.gov (United States)

    Steffen, K.; Schweiger, A. J.

    1990-01-01

    The validation of sea ice products derived from the Special Sensor Microwave Imager (SSM/I) on board a DMSP platform is examined using data from the Landsat MSS and NOAA-AVHRR sensors. Image processing techniques for retrieving ice concentrations from each type of imagery are developed and results are intercompared to determine the ice parameter retrieval accuracy of the SSM/I NASA-Team algorithm. For case studies in the Beaufort Sea and East Greenland Sea, average retrieval errors of the SSM/I algorithm are between 1.7 percent for spring conditions and 4.3 percent during freeze up in comparison with Landsat derived ice concentrations. For a case study in the East Greenland Sea, SSM/I derived ice concentration in comparison with AVHRR imagery display a mean error of 9.6 percent.

  4. Conversion of native terrestrial ecosystems in Hawai‘i to novel grazing systems: a review

    Science.gov (United States)

    Leopold, Christina R.; Hess, Steven C.

    2017-01-01

    The remote oceanic islands of Hawai‘i exemplify the transformative effects that non-native herbivorous mammals can bring to isolated terrestrial ecosystems. We reviewed published literature containing systematically collected, analyzed, and peer-reviewed original data specifically addressing direct effects of non-native hoofed mammals (ungulates) on terrestrial ecosystems, and indirect effects and interactions on ecosystem processes in Hawai‘i. The effects of ungulates on native vegetation and ecosystems were addressed in 58 original studies and mostly showed strong short-term regeneration of dominant native trees and understory ferns after ungulate removal, but unassisted recovery was dependent on the extent of previous degradation. Ungulates were associated with herbivory, bark-stripping, disturbance by hoof action, soil erosion, enhanced nutrient cycling from the interaction of herbivory and grasses, and increased pyrogenicity and competition between native plants and pasture grasses. No studies demonstrated that ungulates benefitted native ecosystems except in short-term fire-risk reduction. However, non-native plants became problematic and continued to proliferate after release from herbivory, including at least 11 species of non-native pasture grasses that had become established prior to ungulate removal. Competition from non-native grasses inhibited native species regeneration where degradation was extensive. These processes have created novel grazing systems which, in some cases, have irreversibly altered Hawaii’s terrestrial ecology. Non-native plant control and outplanting of rarer native species will be necessary for recovery where degradation has been extensive. Lack of unassisted recovery in some locations should not be construed as a reason to not attempt restoration of other ecosystems.

  5. Career Preparation: A Longitudinal, Process-Oriented Examination

    OpenAIRE

    Stringer, Kate; Kerpelman, Jennifer; Skorikov, Vladimir

    2011-01-01

    Preparing for an adult career through careful planning, choosing a career, and gaining confidence to achieve career goals is a primary task during adolescence and early adulthood. The current study bridged identity process literature and career construction theory (Savickas, 2005) by examining the commitment component of career adaptability, career preparation (i.e., career planning, career decision-making, and career confidence), from an identity process perspective (Luyckx, Goossens, & Soen...

  6. Vegetation response of a dry shrubland community to feral goat management on the island of Moloka‘i, Hawai‘i

    Science.gov (United States)

    Jacobi, James D.; Stock, Jonathan

    2017-12-14

    The Hawaiian Islands are well known for their unique ecosystem assemblages that have a high proportion of endemic flora and fauna. However, since human colonization of this archipelago—starting with the arrival of Polynesian sailors approximately 1,200 years ago, and particularly following western contact in 1778—thousands of non-native species have been introduced to the Islands and many of these alien species have had severe impacts on the native ecosystems. Particularly damaging to these ecosystems are large mammals, including goats (Capra hircus), pigs (Sus scrofa), cattle (Bos taurus), deer (Axis axis and Odocoileus hemionus), and sheep (Ovis spp.), which are collectively referred to here as ungulates; they cause extensive damage to the native vegetation by their browsing, grazing, and trampling. Similar impacts have been documented elsewhere, including New Zealand and many other island ecosystems.Previous studies in Hawai‘i have utilized fenced exclosures to assess the impacts of feral or wild ungulates on vegetation and the recovery potential for the native plant communities by comparing plant community composition, structure, and cover inside the fenced area (without ungulates) over time to the vegetation condition outside of the protection of the fence. In some cases, the native vegetation recovered once the animals were removed. However, in other situations alien plants were more competitive and dominated the revegetation process after the impacts of ungulates had been reduced or eliminated.This report describes the response of a highly degraded lowland dry habitat plant community located on the south slope of east Moloka‘i, Hawai‘i, to reduction of browsing and grazing impacts caused by feral goats. For this study, vegetation response inside a fenced exclosure was compared to vegetation change in the area outside of the fence that was still accessible to goats. This study is part of the larger U.S. Geological Survey Ridge-to-Reef (USGS-R2R

  7. Proteasome, transporter associated with antigen processing, and class I genes in the nurse shark Ginglymostoma cirratum: evidence for a stable class I region and MHC haplotype lineages.

    Science.gov (United States)

    Ohta, Yuko; McKinney, E Churchill; Criscitiello, Michael F; Flajnik, Martin F

    2002-01-15

    Cartilaginous fish (e.g., sharks) are derived from the oldest vertebrate ancestor having an adaptive immune system, and thus are key models for examining MHC evolution. Previously, family studies in two shark species showed that classical class I (UAA) and class II genes are genetically linked. In this study, we show that proteasome genes LMP2 and LMP7, shark-specific LMP7-like, and the TAP1/2 genes are linked to class I/II. Functional LMP7 and LMP7-like genes, as well as multiple LMP2 genes or gene fragments, are found only in some sharks, suggesting that different sets of peptides might be generated depending upon inherited MHC haplotypes. Cosmid clones bearing the MHC-linked classical class I genes were isolated and shown to contain proteasome gene fragments. A non-MHC-linked LMP7 gene also was identified on another cosmid, but only two exons of this gene were detected, closely linked to a class I pseudogene (UAA-NC2); this region probably resulted from a recent duplication and translocation from the functional MHC. Tight linkage of proteasome and class I genes, in comparison with gene organizations of other vertebrates, suggests a primordial MHC organization. Another nonclassical class I gene (UAA-NC1) was detected that is linked neither to MHC nor to UAA-NC2; its high level of sequence similarity to UAA suggests that UAA-NC1 also was recently derived from UAA and translocated from MHC. These data further support the principle of a primordial class I region with few class I genes. Finally, multiple paternities in one family were demonstrated, with potential segregation distortions.

  8. WTO oversight over bilateral agreements: from a notification to an examination process?

    DEFF Research Database (Denmark)

    Mortensen, Jens Ladefoged

    2014-01-01

    The TTIP will – like other free trade agreements (FTAs) – violate one of the cornerstones of the WTO, i.e. the Most-Favoured-Nation (MFN) principle. However, the multilateral trading system has since 1947 permitted the formation of trading blocks and preferential bilateral trading partnerships....... This contribution asks how the WTO can fulfill its task of ensuring that FTAs do not systematically undermine the multilateral trading order. It focuses on the issue of transparency in the current oversight process and discusses whether the WTO secretariat should be granted a stronger mandate to proactively...... investigate the economic effects of the notified FTAs....

  9. Professional judgment in the Data Quality Objectives process: A Bayesian approach to screening assessment

    International Nuclear Information System (INIS)

    Black, P.K.; Neptune, M.D.; Ryti, R.T.; Hickmott, D.D.

    1994-01-01

    The Data Quality Objectives (DQO) process provides a logical planning structure for specifying the optimal sample allocation for defensible decision making, depending on acceptable levels of decision uncertainty and anticipated sampling and measurement errors. These planning inputs must be established prior to designing the data collection activity. Application of the DQO process has traditionally been performed under the framework of Classical statistical theory; elicited decision errors have been interpreted as Classical Type I and Type II errors; mean and variance constraints have been incorporated based on historical information; and, Classical statistical testing methods have been used to determine optimal sample sizes. However, decision errors are usually stated, for dichotomous hypotheses, in terms of the probability of making a false positive or false negative decision; these probabilities, at best, relate loosely to probabilities of Classical Type I and Type II errors. Statements of Classical error types are couched in the language of the probability of rejection of hypotheses as opposed to the probability that a hypothesis is correct. Also, historical or archival data are often insufficient to adequately support prior judgments of means and variances. In many circumstances, however, expert knowledge and opinion is not only available, but is substantial. Finally, a paradigm that provides solutions for other than dichotomous decision problems offers greater diversity for solving real world problems

  10. A Conceptual Model of the Cognitive Processing of Environmental Distance Information

    Science.gov (United States)

    Montello, Daniel R.

    I review theories and research on the cognitive processing of environmental distance information by humans, particularly that acquired via direct experience in the environment. The cognitive processes I consider for acquiring and thinking about environmental distance information include working-memory, nonmediated, hybrid, and simple-retrieval processes. Based on my review of the research literature, and additional considerations about the sources of distance information and the situations in which it is used, I propose an integrative conceptual model to explain the cognitive processing of distance information that takes account of the plurality of possible processes and information sources, and describes conditions under which particular processes and sources are likely to operate. The mechanism of summing vista distances is identified as widely important in situations with good visual access to the environment. Heuristics based on time, effort, or other information are likely to play their most important role when sensory access is restricted.

  11. Small RNA and A-to-I Editing in Autism Spectrum Disorders

    Science.gov (United States)

    Eran, Alal

    One in every 88 children is diagnosed with Autism Spectrum Disorders (ASDs), a set of neurodevelopmental conditions characterized by social impairments, communication deficits, and repetitive behavior. ASDs have a substantial genetic component, but the specific cause of most cases remains unknown. Understanding gene-environment interactions underlying ASD is essential for improving early diagnosis and identifying critical targets for intervention and prevention. Towards this goal, we surveyed adenosine-to-inosine (A-to-I) RNA editing in autistic brains. A-to-I editing is an epigenetic mechanism that fine-tunes synaptic function in response to environmental stimuli, shown to modulate complex behavior in animals. We used ultradeep sequencing to quantify A-to-I receding of candidate synaptic genes in postmortem cerebella from individuals with ASD and neurotypical controls. We found unexpectedly wide distributions of human A-to-I editing levels, whose extremes were consistently populated by individuals with ASD. We correlated A-to-I editing with isoform usage, identified clusters of correlated sites, and examined differential editing patterns. Importantly, we found that individuals with ASD commonly use a dysfunctional form of the editing enzyme ADARB1. We next profiled small RNAs thought to regulate A-to-I editing, which originate from one of the most commonly altered loci in ASD, 15q11. Deep targeted sequencing of SNORD115 and SNORD116 transcripts enabled their high-resolution detection in human brains, and revealed a strong gender bias underlying their expression. The consistent 2-fold upregulation of 15q11 small RNAs in male vs. female cerebella could be important in delineating the role of this locus in ASD, a male dominant disorder. Overall, these studies provide an accurate population-level view of small RNA and A-to-I editing in human cerebella, and suggest that A-to-I editing of synaptic genes may be informative for assessing the epigenetic risk for autism

  12. Proposing a Process-Oriented Systems Research for Systems Thinking Development

    Directory of Open Access Journals (Sweden)

    Jae Eon Yu

    2017-04-01

    Full Text Available This paper discusses systems thinking development from Churchman’s systems ideas related to critical systems practice that appreciates the use of systems methods from sociolinguistic perspectives and poststructuralist thought. Systems research enabled us to understand and reinterpret Churchman’s philosophy and systems approach through the works of Deleuze and Foucault. Based upon the interpretation of Churchman’s philosophy and systems approach, I propose ‘process-oriented systems research’ developed from the use of social appreciative process and Churchman’s metasystem approach. By applying a metasystem approach into practice, I basically appreciate Deleuzian ethics and Foucault’s theory of discourse in order to deal with issues of power and knowledge, and metaethics or moral epistemology, where the meaning of good or bad is discussed. A detailed account of an application of process-oriented systems research is given to demonstrate how I use systems methods to examine the usefulness of the systems research in practice.

  13. Mapping, Navigation, and Learning for Off-Road Traversal

    DEFF Research Database (Denmark)

    Konolige, Kurt; Agrawal, Motilal; Blas, Morten Rufus

    2009-01-01

    The challenge in the DARPA Learning Applied to Ground Robots (LAGR) project is to autonomously navigate a small robot using stereo vision as the main sensor. During this project, we demonstrated a complete autonomous system for off-road navigation in unstructured environments, using stereo vision......, online terrain traversability learning, visual odometry, map registration, planning, and control. At the end of 3 years, the system we developed outperformed all nine other teams in final blind tests over previously unseen terrain.......The challenge in the DARPA Learning Applied to Ground Robots (LAGR) project is to autonomously navigate a small robot using stereo vision as the main sensor. During this project, we demonstrated a complete autonomous system for off-road navigation in unstructured environments, using stereo vision...

  14. "Just another hoop to jump through?" using environmental laws and processes to protect indigenous rights.

    Science.gov (United States)

    Middleton, Beth Rose

    2013-11-01

    Protection of culturally important indigenous landscapes has become an increasingly important component of environmental management processes, for both companies and individuals striving to comply with environmental regulations, and for indigenous groups seeking stronger laws to support site protection and cultural/human rights. Given that indigenous stewardship of culturally important sites, species, and practices continues to be threatened or prohibited on lands out of indigenous ownership, this paper examines whether or not indigenous people can meaningfully apply mainstream environmental management laws and processes to achieve protection of traditional sites and associated stewardship activities. While environmental laws can provide a "back door" to protect traditional sites and practices, they are not made for this purpose, and, as such, require specific amendments to become more useful for indigenous practitioners. Acknowledging thoughtful critiques of the cultural incommensurability of environmental law with indigenous environmental stewardship of sacred sites, I interrogate the ability of four specific environmental laws and processes-the Uniform Conservation Easement Act; the National Environmental Policy Act and the California Environmental Quality Act; the Pacific Stewardship Council land divestiture process; and Senate Bill 18 (CA-2004)-to protect culturally important landscapes and practices. I offer suggestions for improving these laws and processes to make them more applicable to indigenous stewardship of traditional landscapes.

  15. Default mode contributions to automated information processing.

    Science.gov (United States)

    Vatansever, Deniz; Menon, David K; Stamatakis, Emmanuel A

    2017-11-28

    Concurrent with mental processes that require rigorous computation and control, a series of automated decisions and actions govern our daily lives, providing efficient and adaptive responses to environmental demands. Using a cognitive flexibility task, we show that a set of brain regions collectively known as the default mode network plays a crucial role in such "autopilot" behavior, i.e., when rapidly selecting appropriate responses under predictable behavioral contexts. While applying learned rules, the default mode network shows both greater activity and connectivity. Furthermore, functional interactions between this network and hippocampal and parahippocampal areas as well as primary visual cortex correlate with the speed of accurate responses. These findings indicate a memory-based "autopilot role" for the default mode network, which may have important implications for our current understanding of healthy and adaptive brain processing.

  16. 30 CFR 57.22202 - Main fans (I-A, I-B, I-C, II-A, III, V-A, and V-B mines).

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Main fans (I-A, I-B, I-C, II-A, III, V-A, and V... Main fans (I-A, I-B, I-C, II-A, III, V-A, and V-B mines). (a) Main fans shall be— (1) Installed on the... mines, provided with an automatic signal device to give an alarm when the fan stops. The signal device...

  17. I am active”: effects of a program to promote active aging

    Directory of Open Access Journals (Sweden)

    Mendoza-Ruvalcaba NM

    2015-05-01

    Full Text Available Neyda Ma Mendoza-Ruvalcaba,1 Elva Dolores Arias-Merino2 1Health Sciences Department, University of Guadalajara, University Center of Tonala Guadalajara, Jalisco, Mexico; 2Public Health Department, University of Guadalajara, University Center of Health Sciences, Guadalajara, Jalisco, Mexico Background: Active aging involves a general lifestyle strategy that allows preservation of both physical and mental health during the aging process. “I am Active” is a program designed to promote active aging by increased physical activity, healthy nutritional habits, and cognitive functioning. The purpose of this study was to assess the effectiveness of this program. Methods: Sixty-four healthy adults aged 60 years or older were recruited from senior centers and randomly allocated to an experimental group (n=31 or a control group (n=33. Baseline, post-test, and 6-month follow-up assessments were performed after the theoretical–practical intervention. Effect sizes were calculated. Results: At the conclusion of the program, the experimental group showed significant improvement compared with the control group in the following domains: physical activity (falls risk, balance, flexibility, self-efficacy, nutrition (self-efficacy and nutritional status, cognitive performance (processing speed and self-efficacy, and quality of life (general, health and functionality, social and economic status. Although some declines were reported, improvements at follow-up remained in self-efficacy for physical activity, self-efficacy for nutrition, and processing speed, and participants had better nutritional status and quality of life overall. Conclusion: Our findings show that this program promotes improvements in domains of active aging, mainly in self-efficacy beliefs as well as in quality of life in healthy elders. Keywords: active aging, successful aging, intervention program, randomized controlled trial

  18. Why I teach the controversy: Using creationism to teach critical thinking

    Directory of Open Access Journals (Sweden)

    P. Lynne eHoney

    2015-06-01

    Full Text Available Creationism and intelligent design are terms used to describe supernatural explanations for the origin of life, and the diversity of species on this planet. Many scientists have argued that the science classroom is no place for discussion of creationism. When I began teaching I did not teach creationism, as I focused instead on my areas of expertise. Over time it became clear that students had questions about creationism, and did not understand the difference between a scientific approach to knowledge and non-scientific approaches. This led me to wonder whether ignoring supernatural views allowed them to remain as viable ‘alternatives’ to scientific hypotheses, in the minds of students. Also, a psychology class is an ideal place to discuss not only the scientific method but also the cognitive errors associated with non-science views. I began to explain creationism in my classes, and to model the scientific thought process that leads to a rejection of creationism. My approach is consistent with research that demonstrates that teaching content alone is insufficient for students to develop critical thinking and my admittedly anecdotal experience leads me to conclude that ‘teaching the controversy’ has benefits for science students.

  19. Implementation of the Danish return-to-work program : process evaluation of a trial in 21 Danish municipalities

    NARCIS (Netherlands)

    Aust, Birgit; Nielsen, Maj Britt D.; Grundtvig, Gry; Buchardt, Helle L.; Ferm, Linnea; Andersen, Irene; Lund, Trine L.; Jelle, Martin Ohmann Claudio; Andersen, Malene F.; Hansen, Jorgen V.; Tverborgvik, Torill; Helverskov, Trine; Bjorner, Jakob Bue; Rugulies, Reiner; Orbaek, Palle; Winzor, Glen; Bultmann, Ute; Poulsen, Otto M.

    Objectives The aim of this study was to evaluate the implementation of the Danish national return-to-work (RTW) program in 21 Danish municipalities. Methods We conducted a structured process evaluation on (i) reach and recruitment, (ii) fidelity, (iii) dose-delivered, (iv) dose-received, and (v)

  20. Implementation of the Danish return-to-work program : process evaluation of a trial in 21 Danish municipalities

    NARCIS (Netherlands)

    Aust, Birgit; Nielsen, Maj Britt D.; Grundtvig, Gry; Buchardt, Helle L.; Ferm, Linnea; Andersen, Irene; Lund, Trine L.; Jelle, Martin Ohmann Claudio; Andersen, Malene F.; Hansen, Jorgen V.; Tverborgvik, Torill; Helverskov, Trine; Bjorner, Jakob Bue; Rugulies, Reiner; Orbaek, Palle; Winzor, Glen; Bultmann, Ute; Poulsen, Otto M.

    2015-01-01

    Objectives The aim of this study was to evaluate the implementation of the Danish national return-to-work (RTW) program in 21 Danish municipalities. Methods We conducted a structured process evaluation on (i) reach and recruitment, (ii) fidelity, (iii) dose-delivered, (iv) dose-received, and (v)

  1. In vivo photosystem I reduction in thermophilic and mesophilic cyanobacteria: The thermal resistance of the process is limited by factors other than the unfolding of the partners

    International Nuclear Information System (INIS)

    Duran, Raul V.; Hervas, Manuel; Rosa, Miguel A. de la; Navarro, Jose A.

    2005-01-01

    Photosystem I reduction by plastocyanin and cytochrome c 6 in cyanobacteria has been extensively studied in vitro, but much less information is provided on this process inside the cell. Here, we report an analysis of the electron transfer from both plastocyanin and cytochrome c 6 to photosystem I in intact cells of several cyanobacterial species, including a comparative study of the temperature effect in mesophilic and thermophilic organisms. Our data show that cytochrome c 6 reduces photosystem I by following a reaction mechanism involving complex formation, whereas the copper-protein follows a simpler collisional mechanism. These results contrast with previous kinetic studies in vitro. The effect of temperature on photosystem I reduction leads us to conclude that the thermal resistance of this process is determined by factors other than the proper stability of the protein partners

  2. Work-family culture, work-family interference and well-being at work : iIs it possible to distinguish between a positive and a negative process?

    NARCIS (Netherlands)

    Peeters, M.C.W.; Wattez, C.; Demerouti, E.; Regt, de W.

    2009-01-01

    Purpose – The purpose of this paper is to examine whether work-family (WF) interference functions as an explaining mechanism in the link between work-family culture and well-being, hereby distinguishing between a negative and a positive process. The negative, energy depleting process initiates from

  3. Podagogy: The iPod as a Learning Technology

    Science.gov (United States)

    Dale, Crispin; Pymm, John M.

    2009-01-01

    With the growing influence of social media on contemporary society, educators have to adapt to new ways of engaging students in the learning process. The use of iPod technologies, as part of this new breed of social media and associated gadgetry, offers fresh opportunities to enhance the student learning experience. As part of a research project…

  4. TSPP - A Collection of FORTRAN Programs for Processing and Manipulating Time Series

    Science.gov (United States)

    Boore, David M.

    2008-01-01

    This report lists a number of FORTRAN programs that I have developed over the years for processing and manipulating strong-motion accelerograms. The collection is titled TSPP, which stands for Time Series Processing Programs. I have excluded 'strong-motion accelerograms' from the title, however, as the boundary between 'strong' and 'weak' motion has become blurred with the advent of broadband sensors and high-dynamic range dataloggers, and many of the programs can be used with any evenly spaced time series, not just acceleration time series. This version of the report is relatively brief, consisting primarily of an annotated list of the programs, with two examples of processing, and a few comments on usage. I do not include a parameter-by-parameter guide to the programs. Future versions might include more examples of processing, illustrating the various parameter choices in the programs. Although these programs have been used by the U.S. Geological Survey, no warranty, expressed or implied, is made by the USGS as to the accuracy or functioning of the programs and related program material, nor shall the fact of distribution constitute any such warranty, and no responsibility is assumed by the USGS in connection therewith. The programs are distributed on an 'as is' basis, with no warranty of support from me. These programs were written for my use and are being publically distributed in the hope that others might find them as useful as I have. I would, however, appreciate being informed about bugs, and I always welcome suggestions for improvements to the codes. Please note that I have made little effort to optimize the coding of the programs or to include a user-friendly interface (many of the programs in this collection have been included in the software usdp (Utility Software for Data Processing), being developed by Akkar et al. (personal communication, 2008); usdp includes a graphical user interface). Speed of execution has been sacrificed in favor of a code that

  5. Assessing potential modifications to the activated sludge process to improve simultaneous removal of a diverse range of micropollutants.

    Science.gov (United States)

    Petrie, Bruce; McAdam, Ewan J; Lester, John N; Cartmell, Elise

    2014-10-01

    It is proposed that wastewater treatment facilities meet legislated discharge limits for a range of micropollutants. However, the heterogeneity of these micropollutants in wastewaters make removal difficult to predict since their chemistry is so diverse. In this study, a range of organic and inorganic micropollutants known to be preferentially removed via different mechanisms were selected to challenge the activated sludge process (ASP) and determine its potential to achieve simultaneous micropollutant removal. At a fixed hydraulic retention time (HRT) of 8 h, the influence of an increase in solids retention time (SRT) on removal was evaluated. Maximum achievable micropollutant removal was recorded for all chemicals (estrogens, nonylphenolics and metals) at the highest SRT studied (27 days). Also, optimisation of HRT by extension to 24 h further augmented organic biodegradation. Most notable was the enhancement in removal of the considerably recalcitrant synthetic estrogen 17α-ethinylestradiol which increased to 65 ± 19%. Regression analysis indicates that this enhanced micropollutant behaviour is ostensibly related to the concomitant reduction in food: microorganism ratio. Interestingly, extended HRT also initiated nonylphenol biodegradation which has not been consistently observed previously in real wastewaters. However, extending HRT increased the solubilisation of particulate bound metals, increasing effluent aqueous metals concentrations (i.e., 0.45 μm filtered) by >100%. This is significant as only the aqueous metal phase is to be considered for environmental compliance. Consequently, identification of an optimum process condition for generic micropollutant removal is expected to favour a more integrated approach where upstream process unit optimisation (i.e., primary sedimentation) is demanded to reduce loading of the particle bound metal phase onto the ASP, thereby enabling longer HRT in the ASP to be considered for optimum removal of organic

  6. Application of pervaporation to IS process (Joint research)

    International Nuclear Information System (INIS)

    Kanagawa, Akihiro; Fukui, Hiroshi; Nishibayashi, Toshiki; Iwatsuki, Jin; Tanaka, Nobuyuki; Onuki, Kaoru

    2007-12-01

    Separation of hydrogen iodide from HIx solution (HI-I 2 -H 2 O mixture) is one of the technical issues in the development of thermochemical IS process. Application of pervaporation (PV) to the concentration of HIx solution in the IS process pilot test plant was discussed from the viewpoints of process heat mass balance, conceptual design of the apparatus, and the corrosion resistance of the membrane module. Compared with the electro-electrodialysis system, the PV system enables the downsizing of apparatus by using hollow fiber membranes, although it does not improve the thermal efficiency of IS process. Immersion tests of commercially available Nafion hollow fiber membrane module in the HIx solution at 100degC indicated the necessity of improving the corrosion resistance of bundle materials. (author)

  7. The characteristics of a successful framing process

    DEFF Research Database (Denmark)

    Haase, Louise Møller

    2017-01-01

    In design schools and university we need to teach students how to frame their projects in ways that create a significant and new perspective on the problem situation as well as clear direction for the solution. We teach students how to engage in user research, prototyping, conceptualization......, business and technology analysis, but often the ability to take information from these different processes and add it together, into a new way of solving the wicked problem, is left for the student to figure out either in a supervised or unsupervised process. Previous research in the framing process has...... mainly focused on describing the different steps in the process or by describing the type of reasoning that lies behind the framing process. Only a few studies have provided insights into the type of actions that is needed to achieve a successful framing process i.e. searching for the paradox in the data...

  8. Children with dyslexia show a reduced processing benefit from bimodal speech information compared to their typically developing peers.

    Science.gov (United States)

    Schaadt, Gesa; van der Meer, Elke; Pannekamp, Ann; Oberecker, Regine; Männel, Claudia

    2018-01-17

    During information processing, individuals benefit from bimodally presented input, as has been demonstrated for speech perception (i.e., printed letters and speech sounds) or the perception of emotional expressions (i.e., facial expression and voice tuning). While typically developing individuals show this bimodal benefit, school children with dyslexia do not. Currently, it is unknown whether the bimodal processing deficit in dyslexia also occurs for visual-auditory speech processing that is independent of reading and spelling acquisition (i.e., no letter-sound knowledge is required). Here, we tested school children with and without spelling problems on their bimodal perception of video-recorded mouth movements pronouncing syllables. We analyzed the event-related potential Mismatch Response (MMR) to visual-auditory speech information and compared this response to the MMR to monomodal speech information (i.e., auditory-only, visual-only). We found a reduced MMR with later onset to visual-auditory speech information in children with spelling problems compared to children without spelling problems. Moreover, when comparing bimodal and monomodal speech perception, we found that children without spelling problems showed significantly larger responses in the visual-auditory experiment compared to the visual-only response, whereas children with spelling problems did not. Our results suggest that children with dyslexia exhibit general difficulties in bimodal speech perception independently of letter-speech sound knowledge, as apparent in altered bimodal speech perception and lacking benefit from bimodal information. This general deficit in children with dyslexia may underlie the previously reported reduced bimodal benefit for letter-speech sound combinations and similar findings in emotion perception. Copyright © 2018 Elsevier Ltd. All rights reserved.

  9. Processes on Uncontrolled Aerodromes and Safety Indicators - Part I

    Directory of Open Access Journals (Sweden)

    Vladimír Plos

    2013-09-01

    Full Text Available This article describes the processes that take place at the beginning of each duty of dispatcher at uncontrolled aerodromes.Thanks to modeling and analysis of these processes, there is a possible to find critical ones and implement precise targeted safety measures.

  10. Reprogramming LCLs to iPSCs Results in Recovery of Donor-Specific Gene Expression Signature.

    Directory of Open Access Journals (Sweden)

    Samantha M Thomas

    2015-05-01

    Full Text Available Renewable in vitro cell cultures, such as lymphoblastoid cell lines (LCLs, have facilitated studies that contributed to our understanding of genetic influence on human traits. However, the degree to which cell lines faithfully maintain differences in donor-specific phenotypes is still debated. We have previously reported that standard cell line maintenance practice results in a loss of donor-specific gene expression signatures in LCLs. An alternative to the LCL model is the induced pluripotent stem cell (iPSC system, which carries the potential to model tissue-specific physiology through the use of differentiation protocols. Still, existing LCL banks represent an important source of starting material for iPSC generation, and it is possible that the disruptions in gene regulation associated with long-term LCL maintenance could persist through the reprogramming process. To address this concern, we studied the effect of reprogramming mature LCL cultures from six unrelated donors to iPSCs on the ensuing gene expression patterns within and between individuals. We show that the reprogramming process results in a recovery of donor-specific gene regulatory signatures, increasing the number of genes with a detectable donor effect by an order of magnitude. The proportion of variation in gene expression statistically attributed to donor increases from 6.9% in LCLs to 24.5% in iPSCs (P < 10-15. Since environmental contributions are unlikely to be a source of individual variation in our system of highly passaged cultured cell lines, our observations suggest that the effect of genotype on gene regulation is more pronounced in iPSCs than in LCLs. Our findings indicate that iPSCs can be a powerful model system for studies of phenotypic variation across individuals in general, and the genetic association with variation in gene regulation in particular. We further conclude that LCLs are an appropriate starting material for iPSC generation.

  11. A Dual Process Approach to Understand Tourists’ Destination Choice Processes

    DEFF Research Database (Denmark)

    Kock, Florian; Josiassen, Alexander; Assaf, Albert

    2017-01-01

    Most studies that investigate tourists' choices of destinations apply the concept of mental destination representations, also referred to as destination image. The present study investigates tourists’ destination choice processes by conceptualizing how different components of destination image...... are mentally processed in tourists' minds. Specifically, the seminal dual processing approach is applied to the destination image literature. By doing this, we argue that some components of mental destination representations are processed systematically while others serve as inputs for heuristics...... that individuals apply to inform their decision making. Understanding how individuals make use of their mental destination representations and how they color their decision-making is essential in order to better explain tourist behavior....

  12. How Do I Deal with Depression and Adjustment to My Spinal Cord Injury?

    Medline Plus

    Full Text Available ... to my SCI? How do I deal with depression and adjustment to my SCI? ☷ ▾ Page contents The ... the moment you are injured. Understanding adjustment and depression Adjustment to paralysis is a process of changing ...

  13. Explaining discontinuity in organizational learning : a process analysis

    NARCIS (Netherlands)

    Berends, J.J.; Lammers, I.S.

    2010-01-01

    This paper offers a process analysis of organizational learning as it unfolds in a social and temporal context. Building upon the 4I framework (Crossan et al. 1999), we examine organizational learning processes in a longitudinal case study of an implementation of knowledge management in an

  14. The role of categorization and scale endpoint comparisons in numerical information processing: A two-process model.

    Science.gov (United States)

    Tao, Tao; Wyer, Robert S; Zheng, Yuhuang

    2017-03-01

    We propose a two-process conceptualization of numerical information processing to describe how people form impressions of a score that is described along a bounded scale. According to the model, people spontaneously categorize a score as high or low. Furthermore, they compare the numerical discrepancy between the score and the endpoint of the scale to which it is closer, if they are not confident of their categorization, and use implications of this comparison as a basis for judgment. As a result, their evaluation of the score is less extreme when the range of numbers along the scale is large (e.g., from 0 to 100) than when it is small (from 0 to 10). Six experiments support this two-process model and demonstrate its generalizability. Specifically, the magnitude of numbers composing the scale has less impact on judgments (a) when the score being evaluated is extreme, (b) when individuals are unmotivated to engage in endpoint comparison processes (i.e., they are low in need for cognition), and (c) when they are unable to do so (i.e., they are under cognitive load). Moreover, the endpoint to which individuals compare the score can depend on their regulatory focus. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  15. Seeking Comfort: Women Mental Health Process in I. R. Iran: A Grounded Theory Study

    Science.gov (United States)

    Mohammadi, Farahnaz; Eftekhari, Monir Baradaran; Dejman, Masoumeh; Forouzan, Ameneh Setareh; Mirabzadeh, Arash

    2014-01-01

    Background: Psychosocial factor is considered as intermediate social determinant of health, because it has powerful effects on health especially in women. Hence deeper understanding of the mental-health process needed for its promotion. The aim of this study was to explore women's experience of the mental-health problem and related action-interactions activities to design the appropriate interventions. Methods: In-depth interviews with women 18-65 years were analyzed according to the grounded theory method. The selection of Participants was based on purposeful and theoretical sampling. Results: In this study, a substantive theory was generated; explaining how female with the mental-health problem handled their main concern, which was identified as their effort to achieve comfort (core variable). The other six categories are elements in this process. Daily stress as a trigger, satisfaction is the end point, marriage is the key point and action - interaction activities in this process are strengthening human essence, Developing life skills and help seeking. Conclusions: Better understanding the mental-health process might be useful to design the interventional program among women with mental-health problems. PMID:24627750

  16. How Can I Clarify My Responsibility as a Headteacher as I Provide Opportunities to Enable All Children in the School to Create Talents?

    Science.gov (United States)

    Cripps, Louise

    2013-01-01

    In this account I explore and clarify my responsibility as I explain how I have come to my current understanding of talent creation, and why I feel it is so important to develop an inclusive approach to talent creation which provides opportunities for all the children to develop talents through their time at school, and to have them recognised and…

  17. Observation of microwave conductivity in copper iodide films and relay effect in the dye molecules attached to CuI photocathode

    International Nuclear Information System (INIS)

    Sirimanne, Prasad M.; Soga, Tetsuo; Kunst, Marinus

    2005-01-01

    Microwave conductivity and two channels of recombination process were observed in the CuI films. Spin orbital splitting resulted in split in the valence band of CuI. The dye molecules attached to the CuI film act as an electron mediator in addition to the sensitization process under back wall-mode illumination. - Graphical abstract: Transient microwave-photoconductivity of CuI film

  18. 31 CFR 363.6 - What special terms do I need to know to understand this part?

    Science.gov (United States)

    2010-07-01

    ... security means a Treasury security held in paper form. De-link means the online process by which all... REGULATIONS GOVERNING SECURITIES HELD IN TREASURYDIRECT General § 363.6 What special terms do I need to know... converted definitive savings bond, or a book-entry security purchased through the TreasuryDirect system...

  19. Holistic curriculum development: tutoring as a support process ...

    African Journals Online (AJOL)

    The tutor's role in these involves different aspects of teaching and learning. In this article I explore the value of tutoring as a means of supporting the holistic curriculum development process. I reflect on the reason for introducing a system of tutoring for students in curriculum studies and the results of its implementation on ...

  20. Consciousness Is a Thing, Not a Process

    Directory of Open Access Journals (Sweden)

    Susan Pockett

    2017-12-01

    Full Text Available The central dogma of cognitive psychology is ‘consciousness is a process, not a thing’. Hence, the main task of cognitive neuroscientists is generally seen as working out what kinds of neural processing are conscious and what kinds are not. I argue here that the central dogma is simply wrong. All neural processing is unconscious. The illusion that some of it is conscious results largely from a failure to separate consciousness per se from a number of unconscious processes that normally accompany it—most particularly focal attention. Conscious sensory experiences are not processes at all. They are things: specifically, spatial electromagnetic (EM patterns, which are presently generated only by ongoing unconscious processing at certain times and places in the mammalian brain, but which in principle could be generated by hardware rather than wetware. The neurophysiological mechanisms by which putatively conscious EM patterns are generated, the features that may distinguish conscious from unconscious patterns, the general principles that distinguish the conscious patterns of different sensory modalities and the general features that distinguish the conscious patterns of different experiences within any given sensory modality are all described. Suggestions for further development of this paradigm are provided.

  1. Mapping absorption processes onto a Markov chain, conserving the mean first passage time

    International Nuclear Information System (INIS)

    Biswas, Katja

    2013-01-01

    The dynamics of a multidimensional system is projected onto a discrete state master equation using the transition rates W(k → k′; t, t + dt) between a set of states {k} represented by the regions {ζ k } in phase or discrete state space. Depending on the dynamics Γ i (t) of the original process and the choice of ζ k , the discretized process can be Markovian or non-Markovian. For absorption processes, it is shown that irrespective of these properties of the projection, a master equation with time-independent transition rates W-bar (k→k ' ) can be obtained, which conserves the total occupation time of the partitions of the phase or discrete state space of the original process. An expression for the transition probabilities p-bar (k ' |k) is derived based on either time-discrete measurements {t i } with variable time stepping Δ (i+1)i = t i+1 − t i or the theoretical knowledge at continuous times t. This allows computational methods of absorbing Markov chains to be used to obtain the mean first passage time (MFPT) of the system. To illustrate this approach, the procedure is applied to obtain the MFPT for the overdamped Brownian motion of particles subject to a system with dichotomous noise and the escape from an entropic barrier. The high accuracy of the simulation results confirms with the theory. (paper)

  2. Succinate-CoA ligase deficiency due to mutations in <i>SUCLA2i> and <i>SUCLG1i>

    DEFF Research Database (Denmark)

    Carrozzo, Rosalba; Verrigni, Daniela; Rasmussen, Magnhild

    2016-01-01

    BACKGROUND: The encephalomyopathic mtDNA depletion syndrome with methylmalonic aciduria is associated with deficiency of succinate-CoA ligase, caused by mutations in SUCLA2 or SUCLG1. We report here 25 new patients with succinate-CoA ligase deficiency, and review the clinical and molecular findings...... deficiency of complexes I and IV, but normal histological and biochemical findings in muscle did not preclude a diagnosis of succinate-CoA ligase deficiency. In five patients, the urinary excretion of methylmalonic acid was only marginally elevated, whereas elevated plasma methylmalonic acid was consistently...

  3. How Do I Deal with Depression and Adjustment to My Spinal Cord Injury?

    Medline Plus

    Full Text Available ... a specific question, our information specialists are available business weekdays, Monday through Friday, toll-free at 800- ... do I need to know about stem cell research? What is the clinical trials process? Get support ...

  4. Computational model of miniature pulsating heat pipes

    Energy Technology Data Exchange (ETDEWEB)

    Martinez, Mario J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Givler, Richard C. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2013-01-01

    The modeling work described herein represents Sandia National Laboratories (SNL) portion of a collaborative three-year project with Northrop Grumman Electronic Systems (NGES) and the University of Missouri to develop an advanced, thermal ground-plane (TGP), which is a device, of planar configuration, that delivers heat from a source to an ambient environment with high efficiency. Work at all three institutions was funded by DARPA/MTO; Sandia was funded under DARPA/MTO project number 015070924. This is the final report on this project for SNL. This report presents a numerical model of a pulsating heat pipe, a device employing a two phase (liquid and its vapor) working fluid confined in a closed loop channel etched/milled into a serpentine configuration in a solid metal plate. The device delivers heat from an evaporator (hot zone) to a condenser (cold zone). This new model includes key physical processes important to the operation of flat plate pulsating heat pipes (e.g. dynamic bubble nucleation, evaporation and condensation), together with conjugate heat transfer with the solid portion of the device. The model qualitatively and quantitatively predicts performance characteristics and metrics, which was demonstrated by favorable comparisons with experimental results on similar configurations. Application of the model also corroborated many previous performance observations with respect to key parameters such as heat load, fill ratio and orientation.

  5. DARPA (Defense Advanced Research Projects Agency) Review on EHF Devices Held in San Diego, California on 24-25 January 1989

    Science.gov (United States)

    1989-04-01

    representing the official policies , either expressed or implied, of the Naval Ocean Systems Center or the U.S. Government. * I I NAVAL OCEAN SYSTEMS CENTER San...0 00 NNNc~ ___CI rI CncD I S zo I II C CC II I II....118 Iz oj z I. w z I w 0 z E 04 ww In jl ~ 11 u -i00 z~zo> Lu 0 F-J LL >- cr 0 - 0- M F-J CL z

  6. Sensitivity of transatlantic dust transport to chemical aging and related atmospheric processes

    KAUST Repository

    Abdelkader, Mohamed; Metzger, Swen; Steil, Benedikt; Klingmü ller, Klaus; Tost, Holger; Pozzer, Andrea; Stenchikov, Georgiy L.; Barrie, Leonard; Lelieveld, Jos

    2017-01-01

    We present a sensitivity study on transatlantic dust transport, a process which has many implications for the atmosphere, the ocean and the climate. We investigate the impact of key processes that control the dust outflow, i.e., the emission flux

  7. [WMN: a negative ERPs component related to working memory during non-target visual stimuli processing].

    Science.gov (United States)

    Zhao, Lun; Wei, Jin-he

    2003-10-01

    To study non-target stimuli processing in the brain. Features of the event-related potentials (ERPs) from non-target stimuli during selective response task (SR) was compared with that during visual selective discrimination (DR) task in 26 normal subjects. The stimuli consisted of two color LED flashes (red and green) appeared randomly in left (LVF) or right (RVF) visual field with same probability. ERPs were derived at 9 electrode sites on the scalp under 2 task conditions: a) SR, making switch response to the target (NT) stimuli from LVF or RVF in one direction and making no response to the non-target (NT) ones; b) DR, making switching response to T stimuli differentially, i.e., to the left for T from LVF and to the right for T from RVF. 1) the non-target stimuli in DR conditions, compared with that in SR condition, elicited smaller P2 and P3 components and larger N2 component at the frontal brain areas; 2) a significant negative component, named as WMN (working memory negativity), appeared in the non-target ERPs during DR in the period of 100 to 700 ms post stimulation which was predominant at the frontal brain areas. According to the major difference between brain activities for non-target stimuli during SR and DR, the predominant appearance of WMN at the frontal brain areas demonstrated that the non-target stimulus processing was an active process and was related to working memory, i.e., the temporary elimination and the retrieval of the response mode which was stored in working memory.

  8. Assembly and Initial Analysis of a Database of the Characteristics of Fixed-Wing Unmanned Aircraft Systems

    Science.gov (United States)

    2014-11-01

    directly (e.g. on their websites or in brochures ) or, in its absence, by Jane’s All the World’s Aircraft: Unmanned [15], as the data it provides is...Proposer Information Pamphlet (PIP) for Defense Advanced Research Projects Agency (DARPA) Defense Sciences Office (DSO) Nano Air Vehicle (NAV

  9. Experimental studies of an optimal operating condition for the Bunsen process in the I-S thermochemical cycle

    International Nuclear Information System (INIS)

    Yoon, Ho Joon; No, Hee Cheon; Kim, Young Soo; Jin, Hyung Gon; Lee, Jeong Ik; Lee, Byung Jin

    2009-01-01

    Conventional I-S cycles have critical limitations in material integrity and thermal efficiency. The HIx and sulfuric acids in high temperature and pressure cause serious material corrosions. They also carry too much water and iodine over the entire processes. To try to find a solution to these problems, KAIST proposed an optimal operating condition of Bunsen section through a parametric study of existing experimental data, and, based on it, devised a new flowsheet. When the contents of water and I 2 in the feed are controlled within the optimal band, HI concentration in HIx phase becomes strongly over-azeotropic. By simple flashing of the over-azeotropic HI solution, highly enriched HI vapor can be obtained, which leads to improved energy efficiency of the cycle. Since the cycle is operable under low pressures, the corrosivity of the operating condition can also be alleviated. In order to validate the previous experimental data and enhance the feasibility of the newly proposed flowsheet, KAIST is performing experiments. Procedure and results of early stage of experiments are introduced in this paper. (author)

  10. Process mining: discovering direct successors in process logs

    NARCIS (Netherlands)

    Maruster, L.; Weijters, A.J.M.M.; Aalst, van der W.M.P.; Bosch, van den A.P.J.; Lange, S.; Satoh, K.; Smith, C.H.

    2002-01-01

    Workflow management technology requires the existence of explicit process models, i.e. a completely specified workflow design needs to be developed in order to enact a given workflow process. Such a workflow design is time consuming and often subjective and incomplete. We propose a learning method

  11. The optimization of peptide cargo bound to MHC class I molecules by the peptide-loading complex.

    Science.gov (United States)

    Elliott, Tim; Williams, Anthony

    2005-10-01

    Major histocompatibility complex (MHC) class I complexes present peptides from both self and foreign intracellular proteins on the surface of most nucleated cells. The assembled heterotrimeric complexes consist of a polymorphic glycosylated heavy chain, non-polymorphic beta(2) microglobulin, and a peptide of typically nine amino acids in length. Assembly of the class I complexes occurs in the endoplasmic reticulum and is assisted by a number of chaperone molecules. A multimolecular unit termed the peptide-loading complex (PLC) is integral to this process. The PLC contains a peptide transporter (transporter associated with antigen processing), a thiooxido-reductase (ERp57), a glycoprotein chaperone (calreticulin), and tapasin, a class I-specific chaperone. We suggest that class I assembly involves a process of optimization where the peptide cargo of the complex is edited by the PLC. Furthermore, this selective peptide loading is biased toward peptides that have a longer off-rate from the assembled complex. We suggest that tapasin is the key chaperone that directs this action of the PLC with secondary contributions from calreticulin and possibly ERp57. We provide a framework model for how this may operate at the molecular level and draw parallels with the proposed mechanism of action of human leukocyte antigen-DM for MHC class II complex optimization.

  12. Webscripter: End-User Tools for Composition Ontology-Enabled Web Services

    National Research Council Canada - National Science Library

    Frank, Martin

    2005-01-01

    ... (schemes or ontologies) with respect to objects. The DARPA Agent Markup Language (DAML), through the use of ontologies, provides a very powerful way to describe objects and their relationships to other objects...

  13. Core Semantics for Public Ontologies

    National Research Council Canada - National Science Library

    Suni, Niranjan

    2005-01-01

    ... (schemas or ontologies) with respect to objects. The DARPA Agent Markup Language (DAML) through the use of ontologies provides a very powerful way to describe objects and their relationships to other objects...

  14. Super-Penrose process due to collisions inside ergosphere

    Science.gov (United States)

    Zaslavskii, O. B.

    If two particles collide inside the ergosphere, the energy in the center of mass frame can be made unbound provided at least one of particles has a large negative angular momentum [A. A. Grib and Yu. V. Pavlov, Europhys. Lett. 101 (2013) 20004]. We show that the same condition can give rise to unbounded Killing energy of debris at infinity, i.e. super-Penrose process. Proximity of the point of collision to the black hole horizon is not required.

  15. Spectrometric study of the folding process of i-motif-forming DNA sequences upstream of the c-kit transcription initiation site

    International Nuclear Information System (INIS)

    Bucek, Pavel; Gargallo, Raimundo; Kudrev, Andrei

    2010-01-01

    The c-kit oncogene shows a cytosine-rich DNA region upstream of the transcription initiation site which forms an i-motif structure at slightly acidic pH values (Bucek et al. ). In the present study, the pH-induced formation of i-motif - forming sequences 5'-CCC CTC CCT CGC GCC CGC CCG-3' (ckitC1, native), 5'-CCC TTC CCT TGT GCC CGC CCG-3' (ckitC2) and 5'-CCCTT CCC TTTTT CCC T CCC T-3' (ckitC3) was studied by spectroscopic techniques, such as UV molecular absorption and circular dichroism (CD), in tandem with two multivariate data analysis methods, the hard modelling-based matrix method and the soft modelling-based MCR-ALS approach. Use of the hard chemical modelling enabled us to propose the equilibrium model, which describes spectral changes as functions of solution acidity. Additionally, the intrinsic protonation constant, K in , and the cooperativity parameters, ω c , and ω a , were calculated from the fitting procedure of the coupled CD and molecular absorption spectra. In the case of ckitC2 and ckitC3, the hard model correctly reproduced the spectral variations observed experimentally. The results indicated that folding was accompanied by a cooperative process, i.e. the enhancement of protonated structure stability upon protonation. In contrast, unfolding was accompanied by an anticooperative process. Finally, folding of the native sequence, ckitC1, seemed to follow a more complex mechanism.

  16. <i>Laserpitium> gr. <i>nestleri> (Umbelliferae

    Directory of Open Access Journals (Sweden)

    Montserrat, Pedro

    2003-12-01

    Full Text Available For the revision of the genus <i>Laserpitium> for Flora lberica I have revised numerous materials of many herbaria. In this paper I present! the result of a morphological and taxonomic study of <i>L. nestlerii> and <i>L. eliasiii>, supported with numerous iIIustrations only partially included here. <i>L. nestlerii> subsp. <i>nestleri> is distributed from Central France (Central Massif to the SE of the lberian Peninsula. Two new subspecies allow to relate the morphological variability observed with their geographical distribution. <i>L. nestlerii> subsp. <i>flabellatum> is found in the Pyrenees and Ihe Cantabrian mountains, and <i>L. nestlerii> subsp. <i>lainzii> is a remarkable endemism located in the mountains of the N of Leon. <i>L. eliasiii> also presents a great morphological variability. Their distribution area is overlapped partially with that of <i>L. nestlerii> subsp. <i>flabellatum>. <i>L. eliasiii> subsp. <i>ordunae> include forms located in the Basque country while the most western populations, from W Galicia and N of Portugal, belong to <i>L. eliasiii> subsp. <i>thalictrifolium>. I propose different new varieties to highlight some remarkable local forms. The study of mericarp section. the distribution of estomate and the morphology of hairs and basal leaves are very useful for delimitate these taxa.

    Con motivo de la revisión del género <i>Laserpitium> para Flora Ibérica he revisado mucho material de distintos herbarios. En este trabajo presento el resultado de un estudio morfológico y taxonómico de las especies <i>L. nestlerii> y <i>L. eliasiii
    >, apoyado en numerosas ilustraciones. de las cuales sólo una pequeña parte se incluyen en este artículo. <i>L. nestlerii> subsp. <i>nestleri> se distribuye desde el Centro de Francia (Massif Central hasta el SE de la Península Ibérica. Dos nuevas subespecies permiten relacionar la variabilidad morfológica observada con su

  17. Markov-modulated infinite-server queues driven by a common background process

    OpenAIRE

    Mandjes , Michel; De Turck , Koen

    2016-01-01

    International audience; This paper studies a system with multiple infinite-server queues which are modulated by a common background process. If this background process, being modeled as a finite-state continuous-time Markov chain, is in state j, then the arrival rate into the i-th queue is λi,j, whereas the service times of customers present in this queue are exponentially distributed with mean µ −1 i,j ; at each of the individual queues all customers present are served in parallel (thus refl...

  18. Development a recovery method of 13I from the 23'5U fission products

    International Nuclear Information System (INIS)

    Bignardi, Aline M.T.; Osso Junior, Joao Alberto

    2013-01-01

    13I is a iodine radioisotope widely used in nuclear medicine that can be used either for diagnostic or for treatment due to its physical decay by β- and its high emission of rays-γ. It is produced at IPEN through the irradiation of TeO 2 targets in the IEA-R1 nuclear reactor. There is also the possibility produced it by the fission of 235 U. The aim of this work is to develop a recovery method of 13I in the production process of 99 Mo through the route of acid dissolution of 235 U targets, with the quality to be used in Nuclear Medicine. 13I finds itself in two stages of the process, either in the gaseous produced in the acid dissolution of metallic U targets and the smallest part in solution. In this work was studied the recovery of 131 in these two stages. Several materials were used for the capture and recovery of 13I at the two phases of the process. Anionic cartridges, Ag cartridges, anion exchange resin, activated charcoal columns and AgI precipitation were tested. Solutions with 13 '1I in 0.1 mol.L -1 NaOH were percolated through the materials and the eluted solutions were analyzed in a dose calibrator. Among all the tests that were executed, at first, the anion exchange resin and AgI precipitation have showed the best retention result (100%). The results of elution have varied according to the material, the activated charcoal presented a elution yield between 70% and 82% At first, it is possible to conclude that anion exchange resin and AgI precipitation show better results for 13I retention and the column and activated charcoal have a great potential for the elution of 131 in the right chemical state. (author)

  19. Are classical process safety concepts relevant to nanotechnology applications?

    International Nuclear Information System (INIS)

    Amyotte, Paul R

    2011-01-01

    The answer to the question posed by the title of this paper is yes - with adaptation to the specific hazards and challenges found in the field of nanotechnology. The validity of this affirmative response is demonstrated by relating key process safety concepts to various aspects of the nanotechnology industry in which these concepts are either already practised or could be further applied. This is accomplished by drawing on the current author's experience in process safety practice and education as well as a review of the relevant literature on the safety of nanomaterials and their production. The process safety concepts selected for analysis include: (i) risk management, (ii) inherently safer design, (iii) human error and human factors, (iv) safety management systems, and (v) safety culture.

  20. A Survey of Mucilaginous Testa in <i>Chamaesyce>

    Directory of Open Access Journals (Sweden)

    Jordan, M. S.

    1992-12-01

    Full Text Available Seeds of <i>Chamaesyce> were studied for presence of mucilaginous testa. Samples were selected to represent all major systematic sections within the genus. Observations were made with a dissecting microscope following brief hydration of seeds; additional SEM observations of both intact and fractured dry seeds were made for selected species. With few exceptions, most of Boissier's subsections test positively fo r seed mucilage; however, mucilage is generally absent in subsections <i>Gymnadeniae> and "<i>Sclerophyllae>", for wich absence of mucilage is regarded as secondary loss from mucilagionus ancestors. Although mucilage production is associated with a well-defined subepidermal layer of macroesclereids, it is the surface layer of cells that actually secrete mucilage. Mucilage secreting cells and macroesclereids of mature testa are interpreted to develop from the epidermal layers of outer and inner integuments, respectively. Seed mucilages may play a role in seed hydration and/or seed dispersal.

    Han estat estudiades les granes de <i>Chamaesyce> segons la presència o no de testa mucilaginosa. Les mostres van ésser seleccionades per tal de representar tot es les principals seccions del gènere. Les observacions han estat fetes al microscopi de disseció desprès d'hidratar breument les llavors; addicionalment s'han fet observacions en el MER de llavors seques, senceres i fracturades , de les espècies seleccionades. Amb poques excepcions, la major part de les subseccions de Boissier presenten els tests de presència de mucílags a les granes positius; no obstant, els mucilags generalment no es presenten en les subseccions <i>Gymnadeniae> i "<i>Scterophyltae>", per a les quals l'absència de mucilags es considerada comuna pèrdua secundària a partir d'avantpassats mucilaginosos. Encara que la producció de mucilags s'associa amb les capes subepidèrmiques ben definides de les macroesclereides, en realitat es la capa de